pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-b2/out-0.05-06-0.01-300-run-b2//th1-pval-1e-01-06-th2-pval-1e-02-02-th3-pval-1e-01-01-run-b2/go_data/2189-2-real-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! cellular response to unfolded protein GO:0034620 19 16 2,000 2,197E-08 5,052E-05 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 5,212E-08 5,994E-05 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 6,938E-08 5,319E-05 ! response to unfolded protein GO:0006986 99 76 2,000 2,729E-06 1,569E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 2,883E-06 1,326E-03 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 2,000 3,187E-06 1,222E-03 GO:0010498|proteasomal protein catabolic process, ! response to protein stimulus GO:0051789 111 81 2,000 3,309E-06 1,087E-03 ! ER-associated protein catabolic process GO:0030433 14 11 1,000 7,546E-06 2,169E-03 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! ovarian follicle development GO:0001541 30 21 1,000 2,876E-05 7,349E-03 ! spermatid development GO:0007286 33 23 1,000 3,463E-05 7,965E-03 ! fat cell differentiation GO:0045444 37 24 1,000 3,777E-05 7,898E-03 ! spermatid differentiation GO:0048515 36 26 1,000 4,446E-05 8,522E-03 ! ovulation cycle process GO:0022602 41 29 1,000 5,551E-05 9,821E-03 ! ovulation cycle GO:0042698 43 30 1,000 5,947E-05 9,769E-03 ! female gonad development GO:0008585 49 33 1,000 7,214E-05 0,01106099 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 8,602E-05 0,01236583 GO:0046660|female sex differentiation, ! response to calcium ion GO:0051592 58 40 1,000 1,064E-04 0,01439849 ! double-strand break repair GO:0006302 67 40 1,000 1,064E-04 0,01359857 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 1,231E-04 0,01490585 ! activation of caspase activity GO:0006919 65 43 1,000 1,231E-04 0,01416056 ! positive regulation of cell cycle GO:0045787 77 45 1,000 1,349E-04 0,01477994 ! response to UV GO:0009411 75 46 1,000 1,411E-04 0,01474659 ! positive regulation of caspase activity GO:0043280 72 48 1,000 1,537E-04 0,01536701 GO:0010952|positive regulation of peptidase activity, ! germ cell development GO:0007281 68 49 1,000 1,602E-04 0,01535046 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 1,736E-04 0,01597091 ! multicellular organism reproduction GO:0032504 83 57 1,000 2,171E-04 0,0192009 GO:0048609|reproductive process in a multicellular organism, ! gonad development GO:0008406 79 57 1,000 2,171E-04 0,01848975 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 2,487E-04 0,02042789 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 2,569E-04 0,02037703 ! cell cycle checkpoint GO:0000075 108 64 1,000 2,738E-04 0,02099186 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 2,738E-04 0,0203147 ! reproductive structure development GO:0048608 90 65 1,000 2,824E-04 0,02030075 ! regulation of caspase activity GO:0043281 97 65 1,000 2,824E-04 0,01968557 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 2,824E-04 0,01910659 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 2,824E-04 0,01856068 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 3,001E-04 0,01917428 ! development of primary sexual characteristics GO:0045137 92 68 1,000 3,092E-04 0,01921772 ! rhythmic process GO:0048511 105 68 1,000 3,092E-04 0,01871199 ! positive regulation of ligase activity GO:0051351 99 69 1,000 3,183E-04 0,01877286 ! response to metal ion GO:0010038 103 70 1,000 3,276E-04 0,01883828 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 3,276E-04 0,01837881 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 3,371E-04 0,01845773 ! regulation of peptidase activity GO:0052547 106 72 1,000 3,466E-04 0,01854004 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 3,466E-04 0,01811867 GO:0045937|positive regulation of phosphate metabolic process, ! mitochondrion organization GO:0007005 104 73 1,000 3,563E-04 0,0182116 ! response to inorganic substance GO:0010035 115 75 1,000 3,761E-04 0,01880505 ! regulation of ligase activity GO:0051340 114 75 1,000 3,761E-04 0,01840494 ! sex differentiation GO:0007548 105 77 1,000 3,964E-04 0,01899488 ! protein ubiquitination GO:0016567 125 77 1,000 3,964E-04 0,01860723 ! positive regulation of protein modification process GO:0031401 107 78 1,000 4,068E-04 0,01871138 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 4,943E-04 0,02229329 ! interphase GO:0051325 159 88 1,000 5,175E-04 0,02289073 ! reproductive developmental process GO:0003006 127 89 1,000 5,293E-04 0,02297073 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 5,413E-04 0,02305334 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 6,156E-04 0,02574124 ! response to light stimulus GO:0009416 153 96 1,000 6,156E-04 0,02528157 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 2,001E-03 0,08072941 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 2,001E-03 0,07933752 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 2,001E-03 0,07799282 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 2,001E-03 0,07669294 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 2,001E-03 0,07543568 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 2,001E-03 0,07421897 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 2,001E-03 0,07304089 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 2,001E-03 0,07189963 ! sleep GO:0030431 11 5 0,000 2,001E-03 0,07079348 ! negative regulation of bone resorption GO:0045779 10 5 0,000 2,001E-03 0,06972085 ! nucleotide-sugar transport GO:0015780 8 5 0,000 2,001E-03 0,06868024 ! regulation of interferon-beta production GO:0032648 5 5 0,000 2,001E-03 0,06767024 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 2,001E-03 0,06668951 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 2,001E-03 0,0657368 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 2,001E-03 0,06481093 ! tongue development GO:0043586 6 5 0,000 2,001E-03 0,06391078 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 2,001E-03 0,06303529 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 2,001E-03 0,06218346 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 2,001E-03 0,06135435 ! cobalt ion transport GO:0006824 9 5 0,000 2,001E-03 0,06054706 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 2,001E-03 0,05976073 ! SMAD protein complex assembly GO:0007183 9 5 0,000 2,001E-03 0,05899457 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 2,001E-03 0,0582478 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 2,001E-03 0,0575197 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 2,001E-03 0,05680958 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 2,001E-03 0,05611678 ! embryonic camera-type eye development GO:0031076 8 5 0,000 2,001E-03 0,05544068 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 2,001E-03 0,05478067 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 2,001E-03 0,05413619 ! adaptation of signaling pathway GO:0022401 7 5 0,000 2,001E-03 0,0535067 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 2,001E-03 0,05289168 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 2,001E-03 0,05229064 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 2,001E-03 0,0517031 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 2,001E-03 0,05112862 ! positive regulation of histone modification GO:0031058 5 5 0,000 2,001E-03 0,05056677 ! malate metabolic process GO:0006108 7 5 0,000 2,001E-03 0,05001713 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 2,001E-03 0,04947931 ! behavioral response to pain GO:0048266 7 5 0,000 2,001E-03 0,04895294 ! clathrin coat assembly GO:0048268 11 5 0,000 2,001E-03 0,04843764 ! phototransduction, visible light GO:0007603 6 5 0,000 2,001E-03 0,04793309 ! regulation of dopamine uptake GO:0051584 9 5 0,000 2,001E-03 0,04743893 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 2,001E-03 0,04695486 ! mating behavior GO:0007617 6 5 0,000 2,001E-03 0,04648057 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 2,001E-03 0,04601576 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 2,001E-03 0,04556016 ! rhythmic behavior GO:0007622 12 5 0,000 2,001E-03 0,04511349 ! copulation GO:0007620 7 5 0,000 2,001E-03 0,0446755 ! glial cell fate commitment GO:0021781 12 5 0,000 2,001E-03 0,04424593 ! protein maturation by protein folding GO:0022417 12 5 0,000 2,001E-03 0,04382454 ! embryonic hemopoiesis GO:0035162 10 5 0,000 2,001E-03 0,0434111 ! regulation of potassium ion transport GO:0043266 9 5 0,000 2,001E-03 0,04300539 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 2,001E-03 0,04260719 ! apoptotic cell clearance GO:0043277 13 5 0,000 2,001E-03 0,0422163 ! lipoprotein particle clearance GO:0034381 9 5 0,000 2,001E-03 0,04183251 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 2,001E-03 0,04145564 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 2,001E-03 0,0410855 ! response to protozoan GO:0001562 9 5 0,000 2,001E-03 0,04072191 ! positive regulation of glycolysis GO:0045821 11 5 0,000 2,001E-03 0,0403647 ! lymph vessel development GO:0001945 7 5 0,000 2,001E-03 0,04001371 ! endochondral ossification GO:0001958 12 5 0,000 2,001E-03 0,03966876 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 2,001E-03 0,03932971 ! parathyroid gland development GO:0060017 8 5 0,000 2,001E-03 0,03899641 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 2,001E-03 0,03866871 ! anagen GO:0042640 6 5 0,000 2,001E-03 0,03834647 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 2,001E-03 0,03802956 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 2,001E-03 0,03771784 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 2,001E-03 0,03741119 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 2,001E-03 0,03710949 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 2,001E-03 0,03681261 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 2,001E-03 0,03652045 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 2,001E-03 0,03623288 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 2,001E-03 0,03594981 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 2,001E-03 0,03567113 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 2,001E-03 0,03539674 ! cardiac muscle fiber development GO:0048739 7 5 0,000 2,001E-03 0,03512654 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 2,001E-03 0,03486043 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 2,001E-03 0,03459832 ! neutrophil mediated immunity GO:0002446 6 5 0,000 2,001E-03 0,03434012 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 2,001E-03 0,03408575 ! ovulation GO:0030728 6 5 0,000 2,001E-03 0,03383512 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 2,001E-03 0,03358815 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 2,001E-03 0,03334476 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 2,001E-03 0,03310487 ! response to pH GO:0009268 9 5 0,000 2,001E-03 0,0328684 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 2,001E-03 0,03263529 ! proline biosynthetic process GO:0006561 6 5 0,000 2,001E-03 0,03240547 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 2,001E-03 0,03217885 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 2,001E-03 0,03195539 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 2,001E-03 0,03173501 ! polyol catabolic process GO:0046174 7 5 0,000 2,001E-03 0,03151765 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 2,001E-03 0,03130324 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 2,001E-03 0,03109173 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 2,001E-03 0,03088306 ! sister chromatid cohesion GO:0007062 9 5 0,000 2,001E-03 0,03067717 ! nerve growth factor processing GO:0032455 7 5 0,000 2,001E-03 0,03047401 ! urea metabolic process GO:0019627 6 5 0,000 2,001E-03 0,03027353 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 2,001E-03 0,03007566 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 2,001E-03 0,02988037 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 2,001E-03 0,02968759 ! neutrophil activation GO:0042119 5 5 0,000 2,001E-03 0,02949728 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 2,001E-03 0,0293094 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 2,001E-03 0,0291239 ! response to food GO:0032094 5 5 0,000 2,001E-03 0,02894073 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 2,001E-03 0,02875985 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 2,001E-03 0,02858122 ! paraxial mesoderm development GO:0048339 9 5 0,000 2,001E-03 0,02840479 ! forebrain neuron development GO:0021884 7 5 0,000 2,001E-03 0,02823053 ! melanosome organization GO:0032438 7 5 0,000 2,001E-03 0,02805839 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 2,001E-03 0,02788834 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 2,001E-03 0,02772034 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 2,001E-03 0,02755435 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 2,001E-03 0,02739033 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 2,001E-03 0,02722826 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 2,001E-03 0,0270681 ! nucleoside transport GO:0015858 6 5 0,000 2,001E-03 0,0269098 ! nucleoside salvage GO:0043174 7 5 0,000 2,001E-03 0,02675335 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 2,001E-03 0,02659871 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 2,001E-03 0,02644584 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 2,001E-03 0,02629472 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 2,001E-03 0,02614532 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 2,001E-03 0,02599761 ! early endosome to late endosome transport GO:0045022 11 5 0,000 2,001E-03 0,02585155 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 2,001E-03 0,02570713 ! depyrimidination GO:0045008 8 5 0,000 2,001E-03 0,02556431 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 2,001E-03 0,02542307 ! 5S class rRNA transcription GO:0042791 8 5 0,000 2,001E-03 0,02528339 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 2,001E-03 0,02514523 ! regulation of centrosome cycle GO:0046605 7 5 0,000 2,001E-03 0,02500857 ! neuronal ion channel clustering GO:0045161 7 5 0,000 2,001E-03 0,02487339 ! sodium ion homeostasis GO:0055078 6 5 0,000 2,001E-03 0,02473966 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 2,001E-03 0,02460736 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 2,001E-03 0,02447647 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 2,001E-03 0,02434696 ! monocyte differentiation GO:0030224 8 5 0,000 2,001E-03 0,02421882 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 2,001E-03 0,02409202 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 2,001E-03 0,02396654 ! centrosome duplication GO:0051298 5 5 0,000 2,001E-03 0,02384236 ! response to UV-C GO:0010225 6 5 0,000 2,001E-03 0,02371947 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 2,001E-03 0,02359783 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 2,001E-03 0,02347743 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 2,001E-03 0,02335826 ! regulation of dendrite development GO:0050773 12 5 0,000 2,001E-03 0,02324028 ! peptidyl-arginine modification GO:0018195 7 5 0,000 2,001E-03 0,0231235 ! positive regulation of organ growth GO:0046622 6 5 0,000 2,001E-03 0,02300788 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 2,001E-03 0,02289341 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 2,001E-03 0,02278008 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 2,001E-03 0,02266786 ! regulation of dopamine secretion GO:0014059 12 5 0,000 2,001E-03 0,02255675 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 2,001E-03 0,02244671 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 2,001E-03 0,02233775 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 2,001E-03 0,02222984 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 2,001E-03 0,02212296 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 2,001E-03 0,02201711 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 2,001E-03 0,02191227 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 2,001E-03 0,02180842 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 2,001E-03 0,02170555 ! neural tube patterning GO:0021532 6 5 0,000 2,001E-03 0,02160364 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 2,001E-03 0,02150269 ! histone demethylation GO:0016577 9 5 0,000 2,001E-03 0,02140268 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 2,001E-03 0,02130359 ! regulation of sterol transport GO:0032371 7 5 0,000 2,001E-03 0,02120542 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 2,001E-03 0,02110815 ! enteric nervous system development GO:0048484 8 5 0,000 2,001E-03 0,02101176 ! establishment of planar polarity GO:0001736 6 5 0,000 2,001E-03 0,02091626 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 2,001E-03 0,02082161 ! muscle cell proliferation GO:0033002 8 5 0,000 2,001E-03 0,02072782 ! transcription termination GO:0006353 8 5 0,000 2,001E-03 0,02063487 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 2,001E-03 0,02054275 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 2,001E-03 0,02045145 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 2,001E-03 0,02036096 ! regulation of respiratory burst GO:0060263 8 5 0,000 2,001E-03 0,02027126 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 2,001E-03 0,02018235 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 2,001E-03 0,02009422 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 2,001E-03 0,02000685 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 2,001E-03 0,01992024 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 2,001E-03 0,01983438 ! apical protein localization GO:0045176 6 5 0,000 2,001E-03 0,01974925 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 2,001E-03 0,01966486 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 2,001E-03 0,01958118 ! galactolipid metabolic process GO:0019374 7 5 0,000 2,001E-03 0,0194982 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 2,001E-03 0,01941593 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 2,001E-03 0,01933435 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 2,001E-03 0,01925346 ! triglyceride catabolic process GO:0019433 6 5 0,000 2,001E-03 0,01917323 ! glial cell migration GO:0008347 10 5 0,000 2,001E-03 0,01909368 ! determination of adult lifespan GO:0008340 8 5 0,000 2,001E-03 0,01901478 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 2,001E-03 0,01893653 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 2,001E-03 0,01885892 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 2,001E-03 0,01878194 ! somatic stem cell maintenance GO:0035019 13 5 0,000 2,001E-03 0,01870559 ! cerebellar cortex formation GO:0021697 6 5 0,000 2,001E-03 0,01862986 ! neural plate development GO:0001840 6 5 0,000 2,001E-03 0,01855474 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 2,001E-03 0,01848023 ! regulation of sensory perception GO:0051931 6 5 0,000 2,001E-03 0,0184063 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 2,001E-03 0,01833297 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 2,001E-03 0,01826022 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 2,001E-03 0,01818805 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 2,001E-03 0,01811644 ! sensory cilium assembly GO:0035058 6 5 0,000 2,001E-03 0,0180454 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 2,001E-03 0,01797491 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 2,001E-03 0,01790497 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 2,001E-03 0,01783557 ! spindle assembly GO:0051225 5 5 0,000 2,001E-03 0,0177667 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 2,001E-03 0,01769837 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 2,001E-03 0,01763056 ! protein amino acid prenylation GO:0018346 9 5 0,000 2,001E-03 0,01756327 ! organ regeneration GO:0031100 7 5 0,000 2,001E-03 0,01749649 ! NAD biosynthetic process GO:0009435 7 5 0,000 2,001E-03 0,01743021 ! carnitine metabolic process GO:0009437 5 5 0,000 2,001E-03 0,01736444 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 2,001E-03 0,01729916 ! cellular anion homeostasis GO:0030002 6 5 0,000 2,001E-03 0,01723437 GO:0055081|anion homeostasis, ! tRNA transcription GO:0009304 11 6 0,000 2,4E-03 0,02060054 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 2,4E-03 0,02052396 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 2,4E-03 0,02044794 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 2,4E-03 0,02037249 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 2,4E-03 0,02029759 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 2,4E-03 0,02022324 ! regulation of helicase activity GO:0051095 11 6 0,000 2,4E-03 0,02014943 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 2,4E-03 0,02007616 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 2,4E-03 0,02000342 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 2,4E-03 0,01993121 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 2,4E-03 0,01985951 ! positive regulation of axon extension GO:0045773 8 6 0,000 2,4E-03 0,01978833 ! prostate gland development GO:0030850 9 6 0,000 2,4E-03 0,01971766 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 2,4E-03 0,01964749 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 2,4E-03 0,01957782 ! forebrain neuron differentiation GO:0021879 9 6 0,000 2,4E-03 0,01950864 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 2,4E-03 0,01943994 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 2,4E-03 0,01937173 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 2,4E-03 0,019304 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 2,4E-03 0,01923674 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 2,4E-03 0,01916994 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 2,4E-03 0,01910361 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 2,4E-03 0,01903774 ! neuron adhesion GO:0007158 9 6 0,000 2,4E-03 0,01897232 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 2,4E-03 0,01890734 ! establishment of tissue polarity GO:0007164 7 6 0,000 2,4E-03 0,01884281 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 2,4E-03 0,01877872 ! signal peptide processing GO:0006465 8 6 0,000 2,4E-03 0,01871506 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 2,4E-03 0,01865184 ! mRNA stabilization GO:0048255 15 6 0,000 2,4E-03 0,01858904 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 2,4E-03 0,01852666 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 2,4E-03 0,0184647 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 2,4E-03 0,01840315 ! opsonization GO:0008228 8 6 0,000 2,4E-03 0,01834201 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 2,4E-03 0,01828127 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 2,4E-03 0,01822094 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 2,4E-03 0,018161 ! protein amino acid dealkylation GO:0008214 11 6 0,000 2,4E-03 0,01810146 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 2,4E-03 0,0180423 ! photoreceptor cell development GO:0042461 10 6 0,000 2,4E-03 0,01798353 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 2,4E-03 0,01792514 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 2,4E-03 0,01786713 ! mechanosensory behavior GO:0007638 8 6 0,000 2,4E-03 0,0178095 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 2,4E-03 0,01775223 ! negative regulation of endocytosis GO:0045806 8 6 0,000 2,4E-03 0,01769533 ! response to interferon-gamma GO:0034341 12 6 0,000 2,4E-03 0,0176388 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 2,4E-03 0,01758262 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 2,4E-03 0,01752681 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 2,4E-03 0,01747134 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 2,4E-03 0,01741623 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 2,4E-03 0,01736146 ! cGMP-mediated signaling GO:0019934 10 6 0,000 2,4E-03 0,01730703 ! activation of MAPKKK activity GO:0000185 10 6 0,000 2,4E-03 0,01725295 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 2,4E-03 0,0171992 ! thymic T cell selection GO:0045061 12 6 0,000 2,4E-03 0,01714579 ! protein lipoylation GO:0009249 10 6 0,000 2,4E-03 0,01709271 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 2,4E-03 0,01703995 ! pigment granule organization GO:0048753 11 6 0,000 2,4E-03 0,01698752 ! drug transport GO:0015893 6 6 0,000 2,4E-03 0,01693541 ! cysteine metabolic process GO:0006534 7 6 0,000 2,4E-03 0,01688362 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 2,4E-03 0,01683215 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 2,4E-03 0,01678098 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 2,4E-03 0,01673013 ! histidine metabolic process GO:0006547 6 6 0,000 2,4E-03 0,01667959 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 2,4E-03 0,01662935 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 2,4E-03 0,01657941 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 2,4E-03 0,01652977 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 2,4E-03 0,01648043 ! adenohypophysis development GO:0021984 10 6 0,000 2,4E-03 0,01643138 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 2,4E-03 0,01638262 ! hyperosmotic response GO:0006972 8 6 0,000 2,4E-03 0,01633415 ! microtubule nucleation GO:0007020 10 6 0,000 2,4E-03 0,01628597 ! ER overload response GO:0006983 7 6 0,000 2,4E-03 0,01623807 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 2,4E-03 0,01619045 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 2,4E-03 0,01614311 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 2,4E-03 0,01609605 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 2,4E-03 0,01604926 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 2,4E-03 0,01600274 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 2,4E-03 0,01595649 ! response to dietary excess GO:0002021 7 6 0,000 2,4E-03 0,0159105 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 2,4E-03 0,01586478 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 2,4E-03 0,01581932 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 2,4E-03 0,01577413 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 2,4E-03 0,01572918 ! glycerol ether catabolic process GO:0044269 8 6 0,000 2,4E-03 0,0156845 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 2,4E-03 0,01564007 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 2,4E-03 0,01559589 ! neuron apoptosis GO:0051402 8 6 0,000 2,4E-03 0,01555195 ! organic alcohol transport GO:0015850 9 6 0,000 2,4E-03 0,01550827 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 2,4E-03 0,01546483 ! T cell mediated immunity GO:0002456 12 6 0,000 2,4E-03 0,01542163 ! male sex determination GO:0030238 9 6 0,000 2,4E-03 0,01537867 ! carnitine transport GO:0015879 8 6 0,000 2,4E-03 0,01533596 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 2,4E-03 0,01529347 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 2,4E-03 0,01525123 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 2,4E-03 0,01520921 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 2,4E-03 0,01516743 ! positive regulation of exocytosis GO:0045921 6 6 0,000 2,4E-03 0,01512587 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 2,4E-03 0,01508455 ! parturition GO:0007567 12 6 0,000 2,4E-03 0,01504344 ! negative regulation of translational initiation GO:0045947 7 6 0,000 2,4E-03 0,01500257 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 2,4E-03 0,01496191 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 2,4E-03 0,01492147 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 2,4E-03 0,01488125 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 2,4E-03 0,01484125 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 2,4E-03 0,01480146 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 2,4E-03 0,01476188 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 2,4E-03 0,01472252 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 2,4E-03 0,01468336 ! macrophage differentiation GO:0030225 10 6 0,000 2,4E-03 0,01464441 ! astrocyte development GO:0014002 14 6 0,000 2,4E-03 0,01460567 ! hyaluronan metabolic process GO:0030212 6 6 0,000 2,4E-03 0,01456713 ! purine base biosynthetic process GO:0009113 14 6 0,000 2,4E-03 0,0145288 ! interaction with symbiont GO:0051702 8 6 0,000 2,4E-03 0,01449067 ! anterograde axon cargo transport GO:0008089 8 6 0,000 2,4E-03 0,01445273 ! skeletal muscle contraction GO:0003009 6 6 0,000 2,4E-03 0,014415 ! eating behavior GO:0042755 6 6 0,000 2,4E-03 0,01437746 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 2,4E-03 0,01434011 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 2,4E-03 0,01430296 ! response to copper ion GO:0046688 9 6 0,000 2,4E-03 0,014266 ! DNA topological change GO:0006265 8 6 0,000 2,4E-03 0,01422924 ! response to exogenous dsRNA GO:0043330 8 6 0,000 2,4E-03 0,01419266 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 2,4E-03 0,01415627 ! establishment of melanosome localization GO:0032401 9 6 0,000 2,4E-03 0,01412006 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 2,4E-03 0,01408404 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 2,4E-03 0,0140482 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 2,4E-03 0,01401255 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 2,4E-03 0,01397707 ! nucleoside catabolic process GO:0009164 6 6 0,000 2,4E-03 0,01394178 ! gas homeostasis GO:0033483 11 6 0,000 2,4E-03 0,01390666 ! hair follicle maturation GO:0048820 7 6 0,000 2,4E-03 0,01387172 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 2,4E-03 0,01383695 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 2,4E-03 0,01380236 ! Schwann cell development GO:0014044 14 6 0,000 2,4E-03 0,01376794 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 2,4E-03 0,01373369 ! dendrite morphogenesis GO:0048813 9 6 0,000 2,4E-03 0,01369961 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 2,4E-03 0,0136657 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 2,4E-03 0,01363196 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 2,4E-03 0,01359838 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 2,4E-03 0,01356497 ! histone ubiquitination GO:0016574 7 6 0,000 2,4E-03 0,01353173 ! regulation of meiosis GO:0040020 10 6 0,000 2,4E-03 0,01349864 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 2,4E-03 0,01346572 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 2,4E-03 0,01343295 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 2,4E-03 0,01340035 ! regulation of mast cell activation GO:0033003 6 6 0,000 2,4E-03 0,0133679 ! membrane to membrane docking GO:0022614 12 6 0,000 2,4E-03 0,01333561 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 2,4E-03 0,01330348 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 2,4E-03 0,0132715 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 2,4E-03 0,01323967 ! receptor internalization GO:0031623 9 6 0,000 2,4E-03 0,013208 ! neutrophil homeostasis GO:0001780 6 6 0,000 2,4E-03 0,01317648 ! coenzyme A metabolic process GO:0015936 9 6 0,000 2,4E-03 0,0131451 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 2,4E-03 0,01311388 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 2,4E-03 0,01308281 ! protein deubiquitination GO:0016579 8 6 0,000 2,4E-03 0,01305188 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 2,4E-03 0,01302109 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 2,4E-03 0,01299046 ! peptidyl-histidine modification GO:0018202 9 6 0,000 2,4E-03 0,01295996 ! axonal fasciculation GO:0007413 9 6 0,000 2,4E-03 0,01292961 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 2,4E-03 0,0128994 ! thiamin metabolic process GO:0006772 6 6 0,000 2,4E-03 0,01286933 ! midbrain development GO:0030901 6 6 0,000 2,4E-03 0,0128394 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 2,4E-03 0,01280961 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 2,4E-03 0,01277996 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 2,4E-03 0,01275045 ! progesterone metabolic process GO:0042448 8 6 0,000 2,4E-03 0,01272107 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 2,4E-03 0,01269183 ! glycolipid catabolic process GO:0019377 13 6 0,000 2,4E-03 0,01266272 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 2,4E-03 0,01263374 ! positive regulation of glucose import GO:0046326 6 6 0,000 2,4E-03 0,01260489 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 2,4E-03 0,01257618 ! adult feeding behavior GO:0008343 6 6 0,000 2,4E-03 0,0125476 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 2,4E-03 0,01251915 ! blastocyst growth GO:0001832 15 6 0,000 2,4E-03 0,01249082 ! pigment granule transport GO:0051904 12 6 0,000 2,4E-03 0,01246263 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 2,4E-03 0,01243456 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 2,4E-03 0,01240662 ! catecholamine transport GO:0051937 7 6 0,000 2,4E-03 0,0123788 ! organ or tissue specific immune response GO:0002251 7 6 0,000 2,4E-03 0,0123511 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 2,4E-03 0,01232354 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 2,4E-03 0,01229609 ! negative regulation of B cell activation GO:0050869 9 6 0,000 2,4E-03 0,01226876 ! protein prenylation GO:0018342 10 6 0,000 2,4E-03 0,01224156 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 2,4E-03 0,01221448 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 2,4E-03 0,01218751 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 2,4E-03 0,01216067 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 2,4E-03 0,01213394 ! positive regulation of coagulation GO:0050820 11 6 0,000 2,4E-03 0,01210733 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 2,8E-03 0,01409189 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 2,8E-03 0,01406113 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 2,8E-03 0,01403049 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 2,8E-03 0,01399999 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 2,8E-03 0,01396962 ! synaptonemal complex assembly GO:0007130 10 7 0,000 2,8E-03 0,01393939 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 2,8E-03 0,01390928 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 2,8E-03 0,0138793 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 2,8E-03 0,01384945 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 2,8E-03 0,01381973 ! reproductive behavior GO:0019098 12 7 0,000 2,8E-03 0,01379014 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 2,8E-03 0,01376068 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 2,8E-03 0,01373133 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 2,8E-03 0,01370212 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 2,8E-03 0,01367303 ! oligopeptide transport GO:0006857 11 7 0,000 2,8E-03 0,01364406 ! protein amino acid sulfation GO:0006477 9 7 0,000 2,8E-03 0,01361521 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 2,8E-03 0,01358649 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 2,8E-03 0,01355789 ! RNA methylation GO:0001510 11 7 0,000 2,8E-03 0,0135294 ! pericardium development GO:0060039 8 7 0,000 2,8E-03 0,01350104 ! macrophage chemotaxis GO:0048246 10 7 0,000 2,8E-03 0,01347279 ! fibril organization GO:0043206 13 7 0,000 2,8E-03 0,01344467 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 2,8E-03 0,01341666 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 2,8E-03 0,01338876 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 2,8E-03 0,01336099 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 2,8E-03 0,01333332 ! lipoprotein transport GO:0042953 9 7 0,000 2,8E-03 0,01330578 ! cerebral cortex cell migration GO:0021795 11 7 0,000 2,8E-03 0,01327834 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 2,8E-03 0,01325102 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 2,8E-03 0,01322381 ! estrogen metabolic process GO:0008210 14 7 0,000 2,8E-03 0,01319671 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 2,8E-03 0,01316973 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 2,8E-03 0,01314285 ! chemosensory behavior GO:0007635 9 7 0,000 2,8E-03 0,01311608 ! microtubule bundle formation GO:0001578 8 7 0,000 2,8E-03 0,01308942 ! T-helper 1 type immune response GO:0042088 11 7 0,000 2,8E-03 0,01306287 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 2,8E-03 0,01303643 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 2,8E-03 0,01301009 ! leukocyte degranulation GO:0043299 10 7 0,000 2,8E-03 0,01298386 ! bile acid and bile salt transport GO:0015721 9 7 0,000 2,8E-03 0,01295774 ! reflex GO:0060004 12 7 0,000 2,8E-03 0,01293172 ! positive regulation of isotype switching GO:0045830 15 7 0,000 2,8E-03 0,0129058 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 2,8E-03 0,01287999 ! protein-cofactor linkage GO:0018065 13 7 0,000 2,8E-03 0,01285428 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 2,8E-03 0,01282868 ! glycerolipid catabolic process GO:0046503 9 7 0,000 2,8E-03 0,01280317 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 2,8E-03 0,01277777 ! spinal cord patterning GO:0021511 7 7 0,000 2,8E-03 0,01275247 ! hemoglobin metabolic process GO:0020027 10 7 0,000 2,8E-03 0,01272726 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 2,8E-03 0,01270216 ! adrenal gland development GO:0030325 17 7 0,000 2,8E-03 0,01267716 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 2,8E-03 0,01265225 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 2,8E-03 0,01262744 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 2,8E-03 0,01260273 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 2,8E-03 0,01257812 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 2,8E-03 0,0125536 ! endosome organization GO:0007032 10 7 0,000 2,8E-03 0,01252918 ! thyroid hormone generation GO:0006590 11 7 0,000 2,8E-03 0,01250485 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 2,8E-03 0,01248061 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 2,8E-03 0,01245647 ! regulation of pigmentation during development GO:0048070 15 7 0,000 2,8E-03 0,01243242 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 2,8E-03 0,01240847 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 2,8E-03 0,01238461 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 2,8E-03 0,01236084 ! galactose metabolic process GO:0006012 10 7 0,000 2,8E-03 0,01233716 ! vesicle fusion GO:0006906 15 7 0,000 2,8E-03 0,01231357 ! intracellular pH reduction GO:0051452 10 7 0,000 2,8E-03 0,01229007 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 2,8E-03 0,01226666 ! organ growth GO:0035265 11 7 0,000 2,8E-03 0,01224334 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 2,8E-03 0,01222011 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 2,8E-03 0,01219696 ! Rac protein signal transduction GO:0016601 7 7 0,000 2,8E-03 0,01217391 ! retinol metabolic process GO:0042572 9 7 0,000 2,8E-03 0,01215094 ! behavioral fear response GO:0001662 13 7 0,000 2,8E-03 0,01212805 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 2,8E-03 0,01210526 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 2,8E-03 0,01208254 ! rRNA modification GO:0000154 12 7 0,000 2,8E-03 0,01205992 ! protein heterooligomerization GO:0051291 10 7 0,000 2,8E-03 0,01203738 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 2,8E-03 0,01201492 ! response to UV-B GO:0010224 11 7 0,000 2,8E-03 0,01199254 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 2,8E-03 0,01197025 ! protein retention in ER lumen GO:0006621 12 7 0,000 2,8E-03 0,01194804 ! intermediate filament organization GO:0045109 11 7 0,000 2,8E-03 0,01192592 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 2,8E-03 0,01190387 ! cardiac muscle cell development GO:0055013 9 7 0,000 2,8E-03 0,01188191 ! fibrinolysis GO:0042730 9 7 0,000 2,8E-03 0,01186003 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 2,8E-03 0,01183823 ! regulation of circadian rhythm GO:0042752 11 7 0,000 2,8E-03 0,01181651 ! B cell lineage commitment GO:0002326 17 7 0,000 2,8E-03 0,01179486 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 2,8E-03 0,0117733 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 2,8E-03 0,01175182 ! response to tropane GO:0014073 13 7 0,000 2,8E-03 0,01173041 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 2,8E-03 0,01170908 ! melanosome localization GO:0032400 10 7 0,000 2,8E-03 0,01168783 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 2,8E-03 0,01166666 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 2,8E-03 0,01164556 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 2,8E-03 0,01162454 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 2,8E-03 0,0116036 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 2,8E-03 0,01158273 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 2,8E-03 0,01156193 ! mast cell activation GO:0045576 9 7 0,000 2,8E-03 0,01154121 ! multicellular organismal aging GO:0010259 11 7 0,000 2,8E-03 0,01152057 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 2,8E-03 0,01149999 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 2,8E-03 0,01147949 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 2,8E-03 0,01145907 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 2,8E-03 0,01143871 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 2,8E-03 0,01141843 ! establishment of nucleus localization GO:0040023 13 7 0,000 2,8E-03 0,01139822 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 2,8E-03 0,01137808 ! T cell lineage commitment GO:0002360 12 7 0,000 2,8E-03 0,01135802 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 2,8E-03 0,01133802 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 2,8E-03 0,01131809 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 2,8E-03 0,01129824 ! regulation of lipid transport GO:0032368 13 7 0,000 2,8E-03 0,01127845 ! response to tumor cell GO:0002347 12 7 0,000 2,8E-03 0,01125873 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 2,8E-03 0,01123909 ! neuroblast proliferation GO:0007405 13 7 0,000 2,8E-03 0,01121951 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 2,8E-03 0,01119999 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 2,8E-03 0,01118055 ! peptidyl-threonine modification GO:0018210 18 7 0,000 2,8E-03 0,01116117 ! diuresis GO:0030146 12 7 0,000 2,8E-03 0,01114186 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 2,8E-03 0,01112262 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 2,8E-03 0,01110344 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 2,8E-03 0,01108433 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 2,8E-03 0,01106529 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 2,8E-03 0,01104631 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 2,8E-03 0,01102739 ! melanin biosynthetic process GO:0042438 8 7 0,000 2,8E-03 0,01100854 ! regulation of synaptogenesis GO:0051963 10 7 0,000 2,8E-03 0,01098975 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 2,8E-03 0,01097103 ! dopamine biosynthetic process GO:0042416 15 7 0,000 2,8E-03 0,01095237 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 2,8E-03 0,01093378 ! lymph node development GO:0048535 9 7 0,000 2,8E-03 0,01091525 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 2,8E-03 0,01089678 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 2,8E-03 0,01087837 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 2,8E-03 0,01086003 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 2,8E-03 0,01084174 ! endosome to lysosome transport GO:0008333 10 7 0,000 2,8E-03 0,01082352 ! ATP catabolic process GO:0006200 10 7 0,000 2,8E-03 0,01080536 ! establishment of pigment granule localization GO:0051905 13 7 0,000 2,8E-03 0,01078726 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 2,8E-03 0,01076922 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 2,8E-03 0,01075125 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 2,8E-03 0,01073333 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 2,8E-03 0,01071547 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 2,8E-03 0,01069767 ! muscle adaptation GO:0043500 12 7 0,000 2,8E-03 0,01067993 ! amino sugar catabolic process GO:0046348 9 7 0,000 2,8E-03 0,01066224 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 2,8E-03 0,01064462 ! retina homeostasis GO:0001895 9 7 0,000 2,8E-03 0,01062706 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 2,8E-03 0,01060955 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 2,8E-03 0,0105921 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 2,8E-03 0,01057471 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 2,8E-03 0,01055737 ! behavioral response to nicotine GO:0035095 11 7 0,000 2,8E-03 0,01054009 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 2,8E-03 0,01052287 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 2,8E-03 0,0105057 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 3,199E-03 0,01198491 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 3,199E-03 0,01196542 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 3,199E-03 0,01194599 ! axon extension GO:0048675 11 8 0,000 3,199E-03 0,01192663 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 3,199E-03 0,01190733 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 3,199E-03 0,0118881 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 3,199E-03 0,01186892 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 3,199E-03 0,01184981 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 3,199E-03 0,01183076 ! cell proliferation in forebrain GO:0021846 10 8 0,000 3,199E-03 0,01181177 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 3,199E-03 0,01179284 ! phosphate transport GO:0006817 10 8 0,000 3,199E-03 0,01177397 ! N-glycan processing GO:0006491 12 8 0,000 3,199E-03 0,01175516 ! Golgi to endosome transport GO:0006895 16 8 0,000 3,199E-03 0,01173642 ! UTP metabolic process GO:0046051 8 8 0,000 3,199E-03 0,01171773 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 3,199E-03 0,0116991 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 3,199E-03 0,01168053 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 3,199E-03 0,01166202 ! neurotransmitter uptake GO:0001504 10 8 0,000 3,199E-03 0,01164356 ! succinate metabolic process GO:0006105 14 8 0,000 3,199E-03 0,01162517 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 3,199E-03 0,01160683 ! smoothened signaling pathway GO:0007224 8 8 0,000 3,199E-03 0,01158856 ! membrane hyperpolarization GO:0060081 10 8 0,000 3,199E-03 0,01157033 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 3,199E-03 0,01155217 ! keratinocyte proliferation GO:0043616 12 8 0,000 3,199E-03 0,01153406 ! middle ear morphogenesis GO:0042474 9 8 0,000 3,199E-03 0,01151601 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 3,199E-03 0,01149802 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 3,199E-03 0,01148008 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 3,199E-03 0,0114622 ! ganglioside metabolic process GO:0001573 15 8 0,000 3,199E-03 0,01144437 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 3,199E-03 0,0114266 ! pseudouridine synthesis GO:0001522 9 8 0,000 3,199E-03 0,01140889 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 3,199E-03 0,01139123 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 3,199E-03 0,01137362 ! endothelial cell differentiation GO:0045446 14 8 0,000 3,199E-03 0,01135607 ! ceramide biosynthetic process GO:0046513 9 8 0,000 3,199E-03 0,01133857 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 3,199E-03 0,01132113 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 3,199E-03 0,01130374 ! astrocyte differentiation GO:0048708 16 8 0,000 3,199E-03 0,0112864 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 3,199E-03 0,01126912 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 3,199E-03 0,01125188 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 3,199E-03 0,01123471 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 3,199E-03 0,01121758 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 3,199E-03 0,01120051 ! melanin metabolic process GO:0006582 12 8 0,000 3,199E-03 0,01118348 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 3,199E-03 0,01116651 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 3,199E-03 0,01114959 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 3,199E-03 0,01113273 ! macrophage activation GO:0042116 12 8 0,000 3,199E-03 0,01111591 ! regulation of type I interferon production GO:0032479 8 8 0,000 3,199E-03 0,01109914 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 3,199E-03 0,01108243 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 3,199E-03 0,01106576 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 3,199E-03 0,01104915 ! regulation of vascular permeability GO:0043114 12 8 0,000 3,199E-03 0,01103258 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 3,199E-03 0,01101607 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 3,199E-03 0,0109996 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 3,199E-03 0,01098318 ! ruffle organization GO:0031529 11 8 0,000 3,199E-03 0,01096681 ! osteoblast development GO:0002076 13 8 0,000 3,199E-03 0,01095049 ! lens development in camera-type eye GO:0002088 10 8 0,000 3,199E-03 0,01093422 ! positive regulation of vasodilation GO:0045909 12 8 0,000 3,199E-03 0,010918 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 3,199E-03 0,01090183 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 3,199E-03 0,0108857 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 3,199E-03 0,01086962 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 3,199E-03 0,01085359 ! Schwann cell differentiation GO:0014037 17 8 0,000 3,199E-03 0,0108376 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 3,199E-03 0,01082167 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 3,199E-03 0,01080577 ! regulation of gliogenesis GO:0014013 20 8 0,000 3,199E-03 0,01078993 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 3,199E-03 0,01077413 ! oligodendrocyte development GO:0014003 8 8 0,000 3,199E-03 0,01075838 ! segment specification GO:0007379 10 8 0,000 3,199E-03 0,01074268 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 3,199E-03 0,01072702 ! cellular extravasation GO:0045123 11 8 0,000 3,199E-03 0,0107114 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 3,199E-03 0,01069583 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 3,199E-03 0,01068031 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 3,199E-03 0,01066483 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 3,199E-03 0,0106494 ! snRNA metabolic process GO:0016073 10 8 0,000 3,199E-03 0,01063401 GO:0016180|snRNA processing, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 0,000 3,199E-03 0,01061866 ! regulation of interleukin-4 production GO:0032673 16 8 0,000 3,199E-03 0,01060336 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 3,199E-03 0,0105881 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 3,199E-03 0,01057289 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 3,199E-03 0,01055772 ! nucleosome disassembly GO:0006337 12 8 0,000 3,199E-03 0,0105426 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 3,199E-03 0,01052751 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 3,199E-03 0,01051247 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 3,199E-03 0,01049748 ! icosanoid secretion GO:0032309 12 8 0,000 3,199E-03 0,01048252 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 3,199E-03 0,01046761 ! leukocyte activation during immune response GO:0002366 13 8 0,000 3,199E-03 0,01045274 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 3,199E-03 0,01043792 ! cerebellum morphogenesis GO:0021587 9 8 0,000 3,199E-03 0,01042313 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 3,199E-03 0,01040839 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 3,199E-03 0,01039369 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 3,199E-03 0,01037903 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 3,199E-03 0,01036441 ! sterol catabolic process GO:0016127 9 8 0,000 3,199E-03 0,01034983 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 3,199E-03 0,0103353 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 3,199E-03 0,0103208 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 3,199E-03 0,01030635 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 3,199E-03 0,01029193 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 3,199E-03 0,01027756 ! prophase GO:0051324 11 8 0,000 3,199E-03 0,01026323 ! S phase GO:0051320 8 8 0,000 3,199E-03 0,01024893 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 3,199E-03 0,01023468 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 3,199E-03 0,01022046 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 3,199E-03 0,01020629 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 3,199E-03 0,01019215 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 3,199E-03 0,01017805 ! hormone catabolic process GO:0042447 13 8 0,000 3,199E-03 0,010164 ! quaternary ammonium group transport GO:0015697 10 8 0,000 3,199E-03 0,01014998 ! myeloid cell homeostasis GO:0002262 8 8 0,000 3,199E-03 0,010136 ! regulation of fibrinolysis GO:0051917 13 8 0,000 3,199E-03 0,01012205 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 3,199E-03 0,01010815 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 3,199E-03 0,01009428 ! regulation of telomere maintenance GO:0032204 10 8 0,000 3,199E-03 0,01008046 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 3,199E-03 0,01006667 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 3,199E-03 0,01005291 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 3,199E-03 0,0100392 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 3,199E-03 0,01002552 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 3,199E-03 0,01001188 ! lamellipodium assembly GO:0030032 9 8 0,000 3,199E-03 9,998E-03 ! regulation of embryonic development GO:0045995 16 8 0,000 3,199E-03 9,985E-03 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 3,199E-03 9,971E-03 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 3,199E-03 9,958E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 3,199E-03 9,944E-03 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 3,599E-03 0,01117025 ! regulation of developmental growth GO:0048638 13 9 0,000 3,599E-03 0,01115519 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 3,599E-03 0,01114018 ! telencephalon cell migration GO:0022029 16 9 0,000 3,599E-03 0,01112521 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 3,599E-03 0,01111027 ! pentose-phosphate shunt GO:0006098 12 9 0,000 3,599E-03 0,01109538 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 3,599E-03 0,01108053 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 3,599E-03 0,01106571 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 3,599E-03 0,01105094 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 3,599E-03 0,0110362 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 3,599E-03 0,01102151 ! GTP metabolic process GO:0046039 9 9 0,000 3,599E-03 0,01100685 ! elastic fiber assembly GO:0048251 13 9 0,000 3,599E-03 0,01099224 ! social behavior GO:0035176 14 9 0,000 3,599E-03 0,01097766 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 3,599E-03 0,01096312 ! artery development GO:0060840 19 9 0,000 3,599E-03 0,01094862 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 3,599E-03 0,01093415 ! regulation of glycolysis GO:0006110 15 9 0,000 3,599E-03 0,01091973 ! response to pain GO:0048265 16 9 0,000 3,599E-03 0,01090534 ! protein complex disassembly GO:0043241 17 9 0,000 3,599E-03 0,01089099 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 3,599E-03 0,01087668 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 3,599E-03 0,01086241 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 3,599E-03 0,01084817 ! lung alveolus development GO:0048286 17 9 0,000 3,599E-03 0,01083397 ! ciliary or flagellar motility GO:0001539 10 9 0,000 3,599E-03 0,01081981 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 3,599E-03 0,01080568 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 3,599E-03 0,0107916 ! regulation of exit from mitosis GO:0007096 12 9 0,000 3,599E-03 0,01077754 ! ventral spinal cord development GO:0021517 11 9 0,000 3,599E-03 0,01076353 ! protein targeting to ER GO:0045047 19 9 0,000 3,599E-03 0,01074955 ! T cell selection GO:0045058 18 9 0,000 3,599E-03 0,01073561 ! endoderm development GO:0007492 12 9 0,000 3,599E-03 0,0107217 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 3,599E-03 0,01070783 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 3,599E-03 0,010694 ! arginine catabolic process GO:0006527 10 9 0,000 3,599E-03 0,0106802 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 3,599E-03 0,01066643 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 3,599E-03 0,01065271 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 3,599E-03 0,01063901 ! phosphagen metabolic process GO:0006599 12 9 0,000 3,599E-03 0,01062536 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 3,599E-03 0,01061174 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 3,599E-03 0,01059815 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 3,599E-03 0,0105846 ! regulation of stress fiber formation GO:0051492 20 9 0,000 3,599E-03 0,01057108 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 3,599E-03 0,01055759 ! mannose metabolic process GO:0006013 9 9 0,000 3,599E-03 0,01054414 ! substrate-bound cell migration GO:0006929 10 9 0,000 3,599E-03 0,01053073 ! receptor clustering GO:0043113 15 9 0,000 3,599E-03 0,01051735 ! epithelial cell development GO:0002064 10 9 0,000 3,599E-03 0,010504 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 3,599E-03 0,01049069 ! retinoic acid metabolic process GO:0042573 11 9 0,000 3,599E-03 0,01047741 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 3,599E-03 0,01046416 ! positive regulation of translational initiation GO:0045948 10 9 0,000 3,599E-03 0,01045095 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 3,599E-03 0,01043777 ! motor axon guidance GO:0008045 14 9 0,000 3,599E-03 0,01042463 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 3,599E-03 0,01041151 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 3,599E-03 0,01039843 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 3,599E-03 0,01038539 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 3,599E-03 0,01037237 ! blastoderm segmentation GO:0007350 11 9 0,000 3,599E-03 0,01035939 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 3,599E-03 0,01034644 ! DNA ligation GO:0006266 14 9 0,000 3,599E-03 0,01033352 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 3,599E-03 0,01032064 ! response to amine stimulus GO:0014075 13 9 0,000 3,599E-03 0,01030779 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 3,599E-03 0,01029497 ! erythrocyte development GO:0048821 11 9 0,000 3,599E-03 0,01028218 ! renal water homeostasis GO:0003091 14 9 0,000 3,599E-03 0,01026942 ! postreplication repair GO:0006301 11 9 0,000 3,599E-03 0,0102567 ! mRNA cleavage GO:0006379 13 9 0,000 3,599E-03 0,010244 ! hindbrain morphogenesis GO:0021575 12 9 0,000 3,599E-03 0,01023134 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 3,599E-03 0,01021871 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 3,599E-03 0,01020611 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 3,599E-03 0,01019354 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 3,599E-03 0,010181 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 3,599E-03 0,01016849 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 3,599E-03 0,01015602 ! acid secretion GO:0046717 14 9 0,000 3,599E-03 0,01014357 ! musculoskeletal movement GO:0050881 11 9 0,000 3,599E-03 0,01013115 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 3,599E-03 0,01011877 ! methionine biosynthetic process GO:0009086 10 9 0,000 3,599E-03 0,01010641 ! purine base metabolic process GO:0006144 18 9 0,000 3,599E-03 0,01009409 ! oocyte differentiation GO:0009994 12 9 0,000 3,599E-03 0,01008179 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 3,599E-03 0,01006953 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 3,599E-03 0,01005729 ! spleen development GO:0048536 15 9 0,000 3,599E-03 0,01004509 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 3,599E-03 0,01003291 ! anterior/posterior axis specification GO:0009948 11 9 0,000 3,599E-03 0,01002077 ! regulation of RNA splicing GO:0043484 14 9 0,000 3,599E-03 0,01000865 ! detection of calcium ion GO:0005513 13 9 0,000 3,599E-03 9,997E-03 ! blastocyst formation GO:0001825 12 9 0,000 3,599E-03 9,985E-03 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 3,599E-03 9,972E-03 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 3,599E-03 9,96E-03 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 3,599E-03 9,949E-03 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 3,599E-03 9,937E-03 ! regulation of amino acid transport GO:0051955 11 9 0,000 3,599E-03 9,925E-03 ! positive regulation of amine transport GO:0051954 15 9 0,000 3,599E-03 9,913E-03 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 3,599E-03 9,901E-03 ! prepulse inhibition GO:0060134 14 9 0,000 3,599E-03 9,889E-03 ! embryonic placenta development GO:0001892 12 9 0,000 3,599E-03 9,877E-03 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 3,599E-03 9,865E-03 ! insulin secretion GO:0030073 17 9 0,000 3,599E-03 9,854E-03 ! sequestering of metal ion GO:0051238 11 9 0,000 3,599E-03 9,842E-03 ! response to nicotine GO:0035094 16 9 0,000 3,599E-03 9,83E-03 ! establishment of cell polarity GO:0030010 12 9 0,000 3,599E-03 9,819E-03 ! nucleus localization GO:0051647 15 9 0,000 3,599E-03 9,807E-03 ! regulation of synapse organization GO:0050807 12 9 0,000 3,599E-03 9,795E-03 ! localization within membrane GO:0051668 15 9 0,000 3,599E-03 9,784E-03 ! negative regulation of muscle development GO:0048635 12 10 0,000 3,998E-03 0,01085627 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 3,998E-03 0,01084347 ! neuron fate specification GO:0048665 11 10 0,000 3,998E-03 0,01083069 ! negative regulation of blood pressure GO:0045776 22 10 0,000 3,998E-03 0,01081795 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 3,998E-03 0,01080524 ! thyroid gland development GO:0030878 19 10 0,000 3,998E-03 0,01079256 ! regulation of B cell proliferation GO:0030888 15 10 0,000 3,998E-03 0,01077991 ! regulation of phosphatase activity GO:0010921 21 10 0,000 3,998E-03 0,01076728 ! synapsis GO:0007129 13 10 0,000 3,998E-03 0,01075469 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 3,998E-03 0,01074213 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 3,998E-03 0,01072959 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 3,998E-03 0,01071709 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 3,998E-03 0,01070461 ! sulfate transport GO:0008272 12 10 0,000 3,998E-03 0,01069216 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 3,998E-03 0,01067974 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 3,998E-03 0,01066735 ! androgen metabolic process GO:0008209 13 10 0,000 3,998E-03 0,01065499 ! phospholipid efflux GO:0033700 16 10 0,000 3,998E-03 0,01064266 ! hippocampus development GO:0021766 19 10 0,000 3,998E-03 0,01063036 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 3,998E-03 0,01061808 ! blood vessel remodeling GO:0001974 21 10 0,000 3,998E-03 0,01060584 ! positive regulation of heart contraction GO:0045823 14 10 0,000 3,998E-03 0,01059362 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 3,998E-03 0,01058143 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 3,998E-03 0,01056926 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 3,998E-03 0,01055713 ! pathogenesis GO:0009405 13 10 0,000 3,998E-03 0,01054502 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 3,998E-03 0,01053294 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 3,998E-03 0,01052089 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 3,998E-03 0,01050887 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 3,998E-03 0,01049687 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 3,998E-03 0,0104849 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 3,998E-03 0,01047296 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 3,998E-03 0,01046105 ! melanocyte differentiation GO:0030318 15 10 0,000 3,998E-03 0,01044916 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 3,998E-03 0,0104373 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 3,998E-03 0,01042546 ! reverse cholesterol transport GO:0043691 16 10 0,000 3,998E-03 0,01041366 ! response to X-ray GO:0010165 16 10 0,000 3,998E-03 0,01040188 ! B cell proliferation GO:0042100 14 10 0,000 3,998E-03 0,01039012 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 3,998E-03 0,0103784 ! regulation of sodium ion transport GO:0002028 15 10 0,000 3,998E-03 0,0103667 ! forebrain cell migration GO:0021885 17 10 0,000 3,998E-03 0,01035502 ! lipid digestion GO:0044241 15 10 0,000 3,998E-03 0,01034337 ! phagocytosis, engulfment GO:0006911 20 10 0,000 3,998E-03 0,01033175 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 3,998E-03 0,01032016 ! UV protection GO:0009650 14 10 0,000 3,998E-03 0,01030859 ! entry into host cell GO:0030260 20 10 0,000 3,998E-03 0,01029704 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 3,998E-03 0,01028552 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 3,998E-03 0,01027403 ! negative regulation of ossification GO:0030279 19 10 0,000 3,998E-03 0,01026257 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 3,998E-03 0,01025112 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 3,998E-03 0,01023971 ! regulation of bone resorption GO:0045124 24 10 0,000 3,998E-03 0,01022832 ! alpha-beta T cell activation GO:0046631 16 10 0,000 3,998E-03 0,01021695 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 3,998E-03 0,01020561 ! regulation of organ growth GO:0046620 11 10 0,000 3,998E-03 0,0101943 ! response to dsRNA GO:0043331 18 10 0,000 3,998E-03 0,01018301 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 3,998E-03 0,01017175 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 3,998E-03 0,01016051 ! embryonic axis specification GO:0000578 12 10 0,000 3,998E-03 0,01014929 ! regulation of B cell differentiation GO:0045577 16 10 0,000 3,998E-03 0,0101381 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 3,998E-03 0,01012694 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 3,998E-03 0,0101158 ! cranial nerve development GO:0021545 12 10 0,000 3,998E-03 0,01010468 ! fucose catabolic process GO:0019317 16 10 0,000 3,998E-03 0,01009359 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 3,998E-03 0,01008252 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 3,998E-03 0,01007148 ! protein sumoylation GO:0016925 12 10 0,000 3,998E-03 0,01006046 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 3,998E-03 0,01004946 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 3,998E-03 0,01003849 ! zymogen activation GO:0031638 14 10 0,000 3,998E-03 0,01002755 ! salivary gland development GO:0007431 22 10 0,000 3,998E-03 0,01001662 ! negative regulation of neurological system process GO:0031645 19 10 0,000 3,998E-03 0,01000572 ! glutathione biosynthetic process GO:0006750 11 10 0,000 3,998E-03 9,995E-03 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 3,998E-03 9,984E-03 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 3,998E-03 9,973E-03 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 3,998E-03 9,962E-03 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 3,998E-03 9,952E-03 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 3,998E-03 9,941E-03 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 3,998E-03 9,93E-03 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 3,998E-03 9,919E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 3,998E-03 9,909E-03 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 3,998E-03 9,898E-03 ! detection of bacterium GO:0016045 10 10 0,000 3,998E-03 9,887E-03 ! embryonic gut development GO:0048566 11 10 0,000 3,998E-03 9,877E-03 ! activation of innate immune response GO:0002218 10 10 0,000 3,998E-03 9,866E-03 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 3,998E-03 9,856E-03 ! cardiac cell differentiation GO:0035051 16 10 0,000 3,998E-03 9,845E-03 ! developmental induction GO:0031128 13 10 0,000 3,998E-03 9,835E-03 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 3,998E-03 9,824E-03 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 3,998E-03 9,814E-03 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 3,998E-03 9,803E-03 ! negative regulation of immune effector process GO:0002698 16 10 0,000 3,998E-03 9,793E-03 ! rRNA transcription GO:0009303 17 11 0,000 4,397E-03 0,01075856 ! respiratory burst GO:0045730 14 11 0,000 4,397E-03 0,01074713 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 4,397E-03 0,01073572 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 4,397E-03 0,01072434 ! virus-host interaction GO:0019048 17 11 0,000 4,397E-03 0,01071298 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 4,397E-03 0,01070164 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 4,397E-03 0,01069033 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 4,397E-03 0,01067904 ! Golgi vesicle budding GO:0048194 17 11 0,000 4,397E-03 0,01066777 ! RNA polyadenylation GO:0043631 19 11 0,000 4,397E-03 0,01065653 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 4,397E-03 0,01064532 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 4,397E-03 0,01063412 ! mating GO:0007618 14 11 0,000 4,397E-03 0,01062295 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 4,397E-03 0,0106118 ! T cell proliferation GO:0042098 20 11 0,000 4,397E-03 0,01060068 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 4,397E-03 0,01058958 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 4,397E-03 0,0105785 ! bone resorption GO:0045453 16 11 0,000 4,397E-03 0,01056745 ! regulated secretory pathway GO:0045055 14 11 0,000 4,397E-03 0,01055642 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 4,397E-03 0,01054541 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 4,397E-03 0,01053443 ! regulation of mRNA processing GO:0050684 18 11 0,000 4,397E-03 0,01052346 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 4,397E-03 0,01051253 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 4,397E-03 0,01050161 ! syncytium formation GO:0006949 15 11 0,000 4,397E-03 0,01049072 ! plasma membrane organization GO:0007009 18 11 0,000 4,397E-03 0,01047984 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 4,397E-03 0,010469 ! focal adhesion formation GO:0048041 24 11 0,000 4,397E-03 0,01045817 ! mitotic spindle organization GO:0007052 15 11 0,000 4,397E-03 0,01044737 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 4,397E-03 0,01043658 ! regulation of intracellular pH GO:0051453 17 11 0,000 4,397E-03 0,01042582 ! membrane protein proteolysis GO:0033619 18 11 0,000 4,397E-03 0,01041509 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 4,397E-03 0,01040437 ! adult heart development GO:0007512 11 11 0,000 4,397E-03 0,01039368 ! chondrocyte differentiation GO:0002062 17 11 0,000 4,397E-03 0,01038301 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 4,397E-03 0,01037236 ! temperature homeostasis GO:0001659 16 11 0,000 4,397E-03 0,01036173 ! L-glutamate transport GO:0015813 16 11 0,000 4,397E-03 0,01035113 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 4,397E-03 0,01034054 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 4,397E-03 0,01032998 ! protein targeting to peroxisome GO:0006625 20 11 0,000 4,397E-03 0,01031944 ! stem cell development GO:0048864 29 11 0,000 4,397E-03 0,01030892 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 4,397E-03 0,01029842 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 4,397E-03 0,01028794 ! regulation of phagocytosis GO:0050764 14 11 0,000 4,397E-03 0,01027749 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 4,397E-03 0,01026706 ! vasoconstriction GO:0042310 15 11 0,000 4,397E-03 0,01025664 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 4,397E-03 0,01024625 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 4,397E-03 0,01023588 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 4,397E-03 0,01022553 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 4,397E-03 0,0102152 ! ribosome assembly GO:0042255 13 11 0,000 4,397E-03 0,01020489 ! nitric oxide metabolic process GO:0046209 14 11 0,000 4,397E-03 0,01019461 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 4,397E-03 0,01018434 ! chromatin silencing GO:0006342 19 11 0,000 4,397E-03 0,01017409 ! nucleosome positioning GO:0016584 13 11 0,000 4,397E-03 0,01016387 ! T cell homeostasis GO:0043029 20 11 0,000 4,397E-03 0,01015366 ! regulation of isotype switching GO:0045191 19 11 0,000 4,397E-03 0,01014348 ! regulation of leukocyte migration GO:0002685 24 11 0,000 4,397E-03 0,01013332 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 4,397E-03 0,01012317 ! protein-chromophore linkage GO:0018298 13 11 0,000 4,397E-03 0,01011305 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 4,397E-03 0,01010295 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 4,397E-03 0,01009286 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 4,397E-03 0,0100828 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 4,397E-03 0,01007276 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 4,397E-03 0,01006274 ! male genitalia development GO:0030539 13 11 0,000 4,397E-03 0,01005273 ! cholesterol efflux GO:0033344 19 11 0,000 4,397E-03 0,01004275 ! digestive tract morphogenesis GO:0048546 15 11 0,000 4,397E-03 0,01003279 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 4,397E-03 0,01002284 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 4,397E-03 0,01001292 ! negative regulation of glucose import GO:0046325 14 11 0,000 4,397E-03 0,01000302 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 4,397E-03 9,993E-03 ! regulation of organic acid transport GO:0032890 17 11 0,000 4,397E-03 9,983E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 4,397E-03 9,973E-03 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 4,397E-03 9,964E-03 ! mRNA 3'-end processing GO:0031124 19 11 0,000 4,397E-03 9,954E-03 ! lysogeny GO:0030069 18 11 0,000 4,397E-03 9,944E-03 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 4,397E-03 9,934E-03 ! acrosome reaction GO:0007340 13 11 0,000 4,397E-03 9,924E-03 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 4,397E-03 9,915E-03 ! lactation GO:0007595 20 12 0,000 4,796E-03 0,01080365 ! reproductive cellular process GO:0048610 14 12 0,000 4,796E-03 0,01079308 ! tRNA modification GO:0006400 14 12 0,000 4,796E-03 0,01078253 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 4,796E-03 0,010772 ! positive regulation of blood pressure GO:0045777 16 12 0,000 4,796E-03 0,01076149 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 4,796E-03 0,010751 ! 'de novo' protein folding GO:0006458 18 12 0,000 4,796E-03 0,01074053 ! dicarboxylic acid transport GO:0006835 22 12 0,000 4,796E-03 0,01073008 ! non-recombinational repair GO:0000726 19 12 0,000 4,796E-03 0,01071965 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 4,796E-03 0,01070925 ! peroxisomal transport GO:0043574 21 12 0,000 4,796E-03 0,01069886 ! cartilage condensation GO:0001502 18 12 0,000 4,796E-03 0,01068849 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 4,796E-03 0,01067815 ! cytokine biosynthetic process GO:0042089 16 12 0,000 4,796E-03 0,01066782 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 4,796E-03 0,01065751 ! heart looping GO:0001947 15 12 0,000 4,796E-03 0,01064722 ! palate development GO:0060021 15 12 0,000 4,796E-03 0,01063696 ! positive regulation of cell growth GO:0030307 16 12 0,000 4,796E-03 0,01062671 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 4,796E-03 0,01061648 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 4,796E-03 0,01060627 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 4,796E-03 0,01059609 ! arginine metabolic process GO:0006525 13 12 0,000 4,796E-03 0,01058592 ! glycoprotein catabolic process GO:0006516 19 12 0,000 4,796E-03 0,01057577 ! methionine metabolic process GO:0006555 13 12 0,000 4,796E-03 0,01056564 ! tyrosine metabolic process GO:0006570 14 12 0,000 4,796E-03 0,01055553 ! Golgi organization GO:0007030 18 12 0,000 4,796E-03 0,01054543 ! cell-cell junction assembly GO:0007043 18 12 0,000 4,796E-03 0,01053536 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 4,796E-03 0,01052531 ! monoamine transport GO:0015844 13 12 0,000 4,796E-03 0,01051528 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 4,796E-03 0,01050526 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 4,796E-03 0,01049527 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 4,796E-03 0,01048529 ! L-amino acid transport GO:0015807 20 12 0,000 4,796E-03 0,01047533 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 4,796E-03 0,01046539 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 4,796E-03 0,01045547 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 4,796E-03 0,01044557 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 4,796E-03 0,01043569 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 4,796E-03 0,01042583 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 4,796E-03 0,01041598 ! cerebellum development GO:0021549 13 12 0,000 4,796E-03 0,01040616 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 4,796E-03 0,01039635 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 4,796E-03 0,01038656 ! histone acetylation GO:0016573 23 12 0,000 4,796E-03 0,01037679 ! histone methylation GO:0016571 15 12 0,000 4,796E-03 0,01036703 ! autonomic nervous system development GO:0048483 23 12 0,000 4,796E-03 0,0103573 ! gland morphogenesis GO:0022612 23 12 0,000 4,796E-03 0,01034758 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 4,796E-03 0,01033789 ! peptidyl-lysine modification GO:0018205 18 12 0,000 4,796E-03 0,01032821 ! negative regulation of protein secretion GO:0050709 20 12 0,000 4,796E-03 0,01031855 ! response to gamma radiation GO:0010332 20 12 0,000 4,796E-03 0,0103089 ! regulation of epidermis development GO:0045682 17 12 0,000 4,796E-03 0,01029928 ! intestinal absorption GO:0050892 19 12 0,000 4,796E-03 0,01028967 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 4,796E-03 0,01028008 ! cAMP biosynthetic process GO:0006171 20 12 0,000 4,796E-03 0,01027051 ! regulation of mRNA stability GO:0043488 27 12 0,000 4,796E-03 0,01026095 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 4,796E-03 0,01025142 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 4,796E-03 0,0102419 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 4,796E-03 0,0102324 ! RNA 3'-end processing GO:0031123 20 12 0,000 4,796E-03 0,01022291 ! microspike assembly GO:0030035 23 12 0,000 4,796E-03 0,01021345 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 4,796E-03 0,010204 ! response to cold GO:0009409 14 12 0,000 4,796E-03 0,01019457 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 5,195E-03 0,01103203 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 5,195E-03 0,01102185 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 5,195E-03 0,01101169 ! cGMP metabolic process GO:0046068 16 13 0,000 5,195E-03 0,01100155 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 5,195E-03 0,01099143 ! water transport GO:0006833 17 13 0,000 5,195E-03 0,01098133 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 5,195E-03 0,01097124 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 5,195E-03 0,01096118 ! lipid localization GO:0010876 24 13 0,000 5,195E-03 0,01095113 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 5,195E-03 0,0109411 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 5,195E-03 0,01093109 ! organelle fusion GO:0048284 28 13 0,000 5,195E-03 0,0109211 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 5,195E-03 0,01091113 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 5,195E-03 0,01090117 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 5,195E-03 0,01089123 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 5,195E-03 0,01088132 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 5,195E-03 0,01087141 ! response to hexose stimulus GO:0009746 19 13 0,000 5,195E-03 0,01086153 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 5,195E-03 0,01085167 ! glutamate metabolic process GO:0006536 18 13 0,000 5,195E-03 0,01084182 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 5,195E-03 0,01083199 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 5,195E-03 0,01082218 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 5,195E-03 0,01081238 ! NAD metabolic process GO:0019674 21 13 0,000 5,195E-03 0,01080261 ! exocrine system development GO:0035272 27 13 0,000 5,195E-03 0,01079285 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 5,195E-03 0,01078311 ! bone mineralization GO:0030282 15 13 0,000 5,195E-03 0,01077339 ! regulation of exocytosis GO:0017157 17 13 0,000 5,195E-03 0,01076368 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 5,195E-03 0,01075399 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 5,195E-03 0,01074432 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 5,195E-03 0,01073467 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 5,195E-03 0,01072503 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 5,195E-03 0,01071541 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 5,195E-03 0,01070581 ! genitalia development GO:0048806 15 13 0,000 5,195E-03 0,01069623 ! regulation of cellular pH GO:0030641 20 13 0,000 5,195E-03 0,01068666 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 5,195E-03 0,01067711 ! cellular pigmentation GO:0033059 24 13 0,000 5,195E-03 0,01066758 ! tissue regeneration GO:0042246 21 13 0,000 5,195E-03 0,01065806 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 5,195E-03 0,01064856 ! cofactor transport GO:0051181 19 13 0,000 5,195E-03 0,01063908 ! NADP metabolic process GO:0006739 18 13 0,000 5,195E-03 0,01062961 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 5,195E-03 0,01062016 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 5,195E-03 0,01061073 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 5,195E-03 0,01060132 ! gas transport GO:0015669 18 13 0,000 5,195E-03 0,01059192 ! regulation of RNA stability GO:0043487 28 13 0,000 5,195E-03 0,01058254 ! heme biosynthetic process GO:0006783 20 13 0,000 5,195E-03 0,01057317 ! regulation of axon extension GO:0030516 23 13 0,000 5,195E-03 0,01056382 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 5,195E-03 0,01055449 ! lymphocyte homeostasis GO:0002260 24 13 0,000 5,195E-03 0,01054518 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 5,195E-03 0,01053588 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 5,195E-03 0,01052659 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 5,195E-03 0,01051733 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 5,195E-03 0,01050808 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 5,593E-03 0,01130451 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 5,593E-03 0,01129458 ! superoxide anion generation GO:0042554 18 14 0,000 5,593E-03 0,01128468 ! neuron maturation GO:0042551 21 14 0,000 5,593E-03 0,01127479 ! regulation of S phase GO:0033261 18 14 0,000 5,593E-03 0,01126491 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 5,593E-03 0,01125506 ! myotube differentiation GO:0014902 21 14 0,000 5,593E-03 0,01124522 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 5,593E-03 0,0112354 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 5,593E-03 0,01122559 ! heterophilic cell adhesion GO:0007157 29 14 0,000 5,593E-03 0,01121581 ! inositol metabolic process GO:0006020 20 14 0,000 5,593E-03 0,01120604 ! aminoglycan catabolic process GO:0006026 18 14 0,000 5,593E-03 0,01119628 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 5,593E-03 0,01118655 ! retina development in camera-type eye GO:0060041 18 14 0,000 5,593E-03 0,01117683 ! cardiac muscle contraction GO:0060048 23 14 0,000 5,593E-03 0,01116713 ! gene silencing by RNA GO:0031047 20 14 0,000 5,593E-03 0,01115744 ! response to cAMP GO:0051591 19 14 0,000 5,593E-03 0,01114777 ! limbic system development GO:0021761 25 14 0,000 5,593E-03 0,01113812 ! startle response GO:0001964 21 14 0,000 5,593E-03 0,01112849 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 5,593E-03 0,01111887 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 5,593E-03 0,01110927 ! activation of MAPKK activity GO:0000186 21 14 0,000 5,593E-03 0,01109968 ! regulation of defense response to virus GO:0050688 24 14 0,000 5,593E-03 0,01109011 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 5,593E-03 0,01108056 ! epidermis morphogenesis GO:0048730 29 14 0,000 5,593E-03 0,01107102 ! glycine metabolic process GO:0006544 22 14 0,000 5,593E-03 0,0110615 ! pituitary gland development GO:0021983 23 14 0,000 5,593E-03 0,011052 ! cellular response to starvation GO:0009267 21 14 0,000 5,593E-03 0,01104251 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 5,593E-03 0,01103304 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 5,593E-03 0,01102359 ! regulation of heart rate GO:0002027 23 14 0,000 5,593E-03 0,01101415 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 5,593E-03 0,01100473 ! negative regulation of caspase activity GO:0043154 20 14 0,000 5,593E-03 0,01099532 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 5,593E-03 0,01098593 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 5,593E-03 0,01097656 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 5,593E-03 0,0109672 ! G1/S transition checkpoint GO:0031575 33 14 0,000 5,593E-03 0,01095786 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 5,593E-03 0,01094854 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 5,593E-03 0,01093923 ! axon cargo transport GO:0008088 27 14 0,000 5,593E-03 0,01092993 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 5,593E-03 0,01092065 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 5,593E-03 0,01091139 ! DNA unwinding during replication GO:0006268 21 14 0,000 5,593E-03 0,01090214 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 5,593E-03 0,01089291 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 5,593E-03 0,0108837 ! mRNA splice site selection GO:0006376 26 14 0,000 5,593E-03 0,0108745 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 5,593E-03 0,01086531 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 5,593E-03 0,01085614 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 5,593E-03 0,01084699 ! sphingolipid catabolic process GO:0030149 23 14 0,000 5,593E-03 0,01083785 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 5,593E-03 0,01082873 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 5,593E-03 0,01081962 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 5,593E-03 0,01081053 ! muscle maintenance GO:0046716 19 14 0,000 5,593E-03 0,01080145 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 5,593E-03 0,01079239 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 5,593E-03 0,01078334 ! regulation of ATPase activity GO:0043462 18 14 0,000 5,593E-03 0,01077431 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 5,593E-03 0,0107653 ! cell killing GO:0001906 20 14 0,000 5,593E-03 0,0107563 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 5,593E-03 0,01074731 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 5,593E-03 0,01073834 ! cilium assembly GO:0042384 20 14 0,000 5,593E-03 0,01072938 ! peptide hormone secretion GO:0030072 23 14 0,000 5,593E-03 0,01072044 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 5,992E-03 0,01147465 ! positive regulation of cell size GO:0045793 20 15 0,000 5,992E-03 0,01146511 ! metencephalon development GO:0022037 19 15 0,000 5,992E-03 0,01145558 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 5,992E-03 0,01144606 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 5,992E-03 0,01143656 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 5,992E-03 0,01142708 ! skin development GO:0043588 25 15 0,000 5,992E-03 0,01141761 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 5,992E-03 0,01140816 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 5,992E-03 0,01139873 ! lipid phosphorylation GO:0046834 23 15 0,000 5,992E-03 0,01138931 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 5,992E-03 0,0113799 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 5,992E-03 0,01137051 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 5,992E-03 0,01136114 ! bile acid metabolic process GO:0008206 22 15 0,000 5,992E-03 0,01135178 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 5,992E-03 0,01134244 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 5,992E-03 0,01133311 ! adult walking behavior GO:0007628 25 15 0,000 5,992E-03 0,0113238 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 5,992E-03 0,0113145 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 5,992E-03 0,01130522 ! myoblast differentiation GO:0045445 27 15 0,000 5,992E-03 0,01129595 ! centrosome cycle GO:0007098 16 15 0,000 5,992E-03 0,0112867 ! positive regulation of proteolysis GO:0045862 19 15 0,000 5,992E-03 0,01127746 ! regulation of survival gene product expression GO:0045884 20 15 0,000 5,992E-03 0,01126824 ! cardiac muscle tissue development GO:0048738 23 15 0,000 5,992E-03 0,01125904 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 5,992E-03 0,01124984 ! cerebral cortex development GO:0021987 29 15 0,000 5,992E-03 0,01124067 ! response to osmotic stress GO:0006970 22 15 0,000 5,992E-03 0,01123151 ! vesicle coating GO:0006901 25 15 0,000 5,992E-03 0,01122236 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 5,992E-03 0,01121323 ! DNA integration GO:0015074 22 15 0,000 5,992E-03 0,01120411 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 5,992E-03 0,01119501 ! peptide secretion GO:0002790 27 15 0,000 5,992E-03 0,01118593 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 5,992E-03 0,01117685 ! regulation of vasodilation GO:0042312 24 15 0,000 5,992E-03 0,0111678 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 5,992E-03 0,01115875 ! neuron recognition GO:0008038 22 15 0,000 5,992E-03 0,01114972 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 5,992E-03 0,01114071 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 5,992E-03 0,01113171 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 5,992E-03 0,01112273 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 5,992E-03 0,01111376 ! peptide biosynthetic process GO:0043043 19 15 0,000 5,992E-03 0,0111048 ! biomineral formation GO:0031214 18 15 0,000 5,992E-03 0,01109586 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 5,992E-03 0,01108693 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 5,992E-03 0,01107802 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 5,992E-03 0,01106912 ! dopamine metabolic process GO:0042417 30 15 0,000 5,992E-03 0,01106024 ! organic cation transport GO:0015695 19 15 0,000 5,992E-03 0,01105137 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 5,992E-03 0,01104252 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 5,992E-03 0,01103367 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 5,992E-03 0,01102485 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 5,992E-03 0,01101604 ! defense response to virus GO:0051607 27 15 0,000 5,992E-03 0,01100724 ! peptide hormone processing GO:0016486 19 15 0,000 5,992E-03 0,01099845 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 5,992E-03 0,01098968 ! protein secretion GO:0009306 27 16 0,000 6,39E-03 0,01171098 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 6,39E-03 0,01170165 ! hormone secretion GO:0046879 25 16 0,000 6,39E-03 0,01169234 ! bone remodeling GO:0046849 24 16 0,000 6,39E-03 0,01168305 ! endothelial cell migration GO:0043542 22 16 0,000 6,39E-03 0,01167377 ! protein amino acid deacetylation GO:0006476 20 16 0,000 6,39E-03 0,0116645 ! protein amino acid acetylation GO:0006473 28 16 0,000 6,39E-03 0,01165525 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 6,39E-03 0,01164602 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 6,39E-03 0,0116368 ! glial cell development GO:0021782 24 16 0,000 6,39E-03 0,01162759 ! patterning of blood vessels GO:0001569 24 16 0,000 6,39E-03 0,0116184 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 6,39E-03 0,01160922 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 6,39E-03 0,01160006 ! protein polyubiquitination GO:0000209 26 16 0,000 6,39E-03 0,01159091 ! complement activation, alternative pathway GO:0006957 16 16 0,000 6,39E-03 0,01158178 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 6,39E-03 0,01157266 ! fructose metabolic process GO:0006000 20 16 0,000 6,39E-03 0,01156355 ! regulation of protein binding GO:0043393 27 16 0,000 6,39E-03 0,01155446 ! regulation of dephosphorylation GO:0035303 33 16 0,000 6,39E-03 0,01154539 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 6,39E-03 0,01153632 ! protein export from nucleus GO:0006611 24 16 0,000 6,39E-03 0,01152727 ! negative regulation of immune response GO:0050777 28 16 0,000 6,39E-03 0,01151824 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 6,39E-03 0,01150922 ! DNA replication initiation GO:0006270 25 16 0,000 6,39E-03 0,01150022 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 6,39E-03 0,01149122 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 6,39E-03 0,01148225 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 6,39E-03 0,01147328 ! diencephalon development GO:0021536 25 16 0,000 6,39E-03 0,01146433 ! oogenesis GO:0048477 23 16 0,000 6,39E-03 0,0114554 ! neural crest cell migration GO:0001755 24 16 0,000 6,39E-03 0,01144648 ! G1 phase GO:0051318 27 16 0,000 6,39E-03 0,01143757 ! neutrophil chemotaxis GO:0030593 21 16 0,000 6,39E-03 0,01142867 ! protein localization in mitochondrion GO:0070585 22 16 0,000 6,39E-03 0,01141979 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 6,39E-03 0,01141093 ! steroid catabolic process GO:0006706 22 16 0,000 6,39E-03 0,01140208 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 6,39E-03 0,01139324 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 6,39E-03 0,01138441 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 6,39E-03 0,0113756 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 6,39E-03 0,0113668 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 6,39E-03 0,01135802 ! sperm-egg recognition GO:0035036 16 16 0,000 6,39E-03 0,01134925 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 6,39E-03 0,01134049 ! nerve development GO:0021675 18 16 0,000 6,39E-03 0,01133175 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 6,39E-03 0,01132302 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 6,39E-03 0,0113143 ! negative regulation of translation GO:0017148 22 16 0,000 6,39E-03 0,0113056 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 6,788E-03 0,0120009 ! positive regulation of cell killing GO:0031343 24 17 0,000 6,788E-03 0,01199169 ! negative regulation of defense response GO:0031348 19 17 0,000 6,788E-03 0,01198248 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 6,788E-03 0,01197329 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 6,788E-03 0,01196412 ! glycerol metabolic process GO:0006071 20 17 0,000 6,788E-03 0,01195496 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 6,788E-03 0,01194581 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 6,788E-03 0,01193668 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 6,788E-03 0,01192756 ! signal complex assembly GO:0007172 29 17 0,000 6,788E-03 0,01191845 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 6,788E-03 0,01190936 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 6,788E-03 0,01190029 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 6,788E-03 0,01189122 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 6,788E-03 0,01188217 ! forelimb morphogenesis GO:0035136 19 17 0,000 6,788E-03 0,01187314 ! memory GO:0007613 25 17 0,000 6,788E-03 0,01186412 ! keratinization GO:0031424 17 17 0,000 6,788E-03 0,01185511 ! negative regulation of ion transport GO:0043271 20 17 0,000 6,788E-03 0,01184611 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 6,788E-03 0,01183713 ! retinoid metabolic process GO:0001523 22 17 0,000 6,788E-03 0,01182816 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 6,788E-03 0,01181921 ! inactivation of MAPK activity GO:0000188 27 17 0,000 6,788E-03 0,01181027 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 6,788E-03 0,01180134 ! DNA duplex unwinding GO:0032508 25 17 0,000 6,788E-03 0,01179243 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 6,788E-03 0,01178353 ! cell-substrate junction assembly GO:0007044 39 17 0,000 6,788E-03 0,01177464 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 6,788E-03 0,01176577 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 6,788E-03 0,01175691 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 6,788E-03 0,01174806 ! membrane budding GO:0006900 29 17 0,000 6,788E-03 0,01173923 ! heme metabolic process GO:0042168 27 17 0,000 6,788E-03 0,01173041 ! actin filament bundle formation GO:0051017 26 17 0,000 6,788E-03 0,0117216 ! neuromuscular junction development GO:0007528 23 17 0,000 6,788E-03 0,01171281 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 6,788E-03 0,01170403 ! body fluid secretion GO:0007589 27 17 0,000 6,788E-03 0,01169526 ! stem cell differentiation GO:0048863 36 17 0,000 6,788E-03 0,01168651 ! nucleobase metabolic process GO:0009112 31 17 0,000 6,788E-03 0,01167777 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 6,788E-03 0,01166904 ! behavioral interaction between organisms GO:0051705 25 17 0,000 6,788E-03 0,01166033 ! sensory perception of pain GO:0019233 23 17 0,000 6,788E-03 0,01165162 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 6,788E-03 0,01164293 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 6,788E-03 0,01163426 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 6,788E-03 0,0116256 ! synaptogenesis GO:0007416 24 17 0,000 6,788E-03 0,01161695 ! peptidyl-serine modification GO:0018209 27 17 0,000 6,788E-03 0,01160831 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 6,788E-03 0,01159968 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 6,788E-03 0,01159107 ! cell-cell junction organization GO:0045216 25 17 0,000 6,788E-03 0,01158247 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 6,788E-03 0,01157389 ! proximal/distal pattern formation GO:0009954 25 17 0,000 6,788E-03 0,01156532 ! aromatic compound catabolic process GO:0019439 22 17 0,000 6,788E-03 0,01155675 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 6,788E-03 0,01154821 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 6,788E-03 0,01153967 ! negative regulation of coagulation GO:0050819 23 17 0,000 6,788E-03 0,01153115 ! positive regulation of DNA replication GO:0045740 29 18 0,000 7,186E-03 0,01219835 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 7,186E-03 0,01218935 ! positive regulation of translation GO:0045727 28 18 0,000 7,186E-03 0,01218037 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 7,186E-03 0,0121714 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 7,186E-03 0,01216244 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 7,186E-03 0,0121535 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 7,186E-03 0,01214457 ! cAMP metabolic process GO:0046058 33 18 0,000 7,186E-03 0,01213565 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 7,186E-03 0,01212675 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 7,186E-03 0,01211786 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 7,186E-03 0,01210898 ! axis specification GO:0009798 26 18 0,000 7,186E-03 0,01210012 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 7,186E-03 0,01209127 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 7,186E-03 0,01208243 ! pancreas development GO:0031016 26 18 0,000 7,186E-03 0,0120736 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 7,186E-03 0,01206479 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 7,186E-03 0,01205599 ! glutamine metabolic process GO:0006541 23 18 0,000 7,186E-03 0,0120472 ! response to retinoic acid GO:0032526 25 18 0,000 7,186E-03 0,01203843 ! pigmentation during development GO:0048066 31 18 0,000 7,186E-03 0,01202967 ! central nervous system neuron development GO:0021954 30 18 0,000 7,186E-03 0,01202092 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 7,186E-03 0,01201218 ! fucose metabolic process GO:0006004 26 18 0,000 7,186E-03 0,01200346 ! response to fungus GO:0009620 19 18 0,000 7,186E-03 0,01199475 ! peptide cross-linking GO:0018149 31 18 0,000 7,186E-03 0,01198605 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 7,186E-03 0,01197736 ! heart process GO:0003015 27 18 0,000 7,186E-03 0,01196869 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 7,186E-03 0,01196003 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 7,186E-03 0,01195138 ! visual learning GO:0008542 35 18 0,000 7,186E-03 0,01194275 ! somitogenesis GO:0001756 24 18 0,000 7,186E-03 0,01193412 ! synaptic vesicle transport GO:0048489 33 18 0,000 7,186E-03 0,01192551 ! detection of chemical stimulus GO:0009593 26 18 0,000 7,186E-03 0,01191692 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 7,186E-03 0,01190833 ! cellular response to nutrient levels GO:0031669 27 18 0,000 7,186E-03 0,01189976 ! regulation of cytokine secretion GO:0050707 26 18 0,000 7,186E-03 0,0118912 ! vitamin transport GO:0051180 24 18 0,000 7,186E-03 0,01188265 ! hormone transport GO:0009914 27 18 0,000 7,186E-03 0,01187411 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 7,186E-03 0,01186559 ! activation of JUN kinase activity GO:0007257 23 18 0,000 7,186E-03 0,01185707 ! terpenoid metabolic process GO:0006721 24 18 0,000 7,186E-03 0,01184857 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 7,186E-03 0,01184009 ! cell-cell recognition GO:0009988 20 18 0,000 7,186E-03 0,01183161 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 7,186E-03 0,01182315 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 7,186E-03 0,0118147 ! regulation of glucose import GO:0046324 21 18 0,000 7,186E-03 0,01180626 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 7,186E-03 0,01179783 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 7,186E-03 0,01178942 ! negative regulation of T cell activation GO:0050868 25 18 0,000 7,186E-03 0,01178101 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 7,186E-03 0,01177262 ! protein import into nucleus, docking GO:0000059 30 19 0,000 7,584E-03 0,01241568 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 7,584E-03 0,01240685 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 7,584E-03 0,01239803 ! positive regulation of ossification GO:0045778 30 19 0,000 7,584E-03 0,01238923 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 7,584E-03 0,01238044 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 7,584E-03 0,01237165 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 7,584E-03 0,01236289 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 7,584E-03 0,01235413 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 7,584E-03 0,01234539 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 7,584E-03 0,01233666 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 7,584E-03 0,01232794 ! regeneration GO:0031099 32 19 0,000 7,584E-03 0,01231923 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 7,584E-03 0,01231054 ! response to alkaloid GO:0043279 32 19 0,000 7,584E-03 0,01230186 ! sensory perception of taste GO:0050909 23 19 0,000 7,584E-03 0,01229319 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 7,584E-03 0,01228453 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 7,584E-03 0,01227589 ! smooth muscle contraction GO:0006939 36 19 0,000 7,584E-03 0,01226725 ! peroxisome organization GO:0007031 29 19 0,000 7,584E-03 0,01225863 ! digestive system process GO:0022600 30 19 0,000 7,584E-03 0,01225002 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 7,584E-03 0,01224143 ! polysaccharide catabolic process GO:0000272 23 19 0,000 7,584E-03 0,01223284 ! response to vitamin A GO:0033189 26 19 0,000 7,584E-03 0,01222427 ! D-ribose metabolic process GO:0006014 25 19 0,000 7,584E-03 0,01221571 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 7,584E-03 0,01220716 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 7,584E-03 0,01219862 ! apoptotic nuclear changes GO:0030262 24 19 0,000 7,584E-03 0,0121901 ! response to starvation GO:0042594 30 19 0,000 7,584E-03 0,01218159 ! sex determination GO:0007530 29 19 0,000 7,584E-03 0,01217309 ! response to lipopolysaccharide GO:0032496 26 19 0,000 7,584E-03 0,0121646 ! plasma membrane fusion GO:0045026 23 19 0,000 7,584E-03 0,01215612 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 7,584E-03 0,01214766 ! cytolysis GO:0019835 20 19 0,000 7,584E-03 0,0121392 ! renal system process GO:0003014 35 19 0,000 7,584E-03 0,01213076 ! vasodilation GO:0042311 33 19 0,000 7,584E-03 0,01212233 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 7,584E-03 0,01211391 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 7,584E-03 0,01210551 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 7,584E-03 0,01209711 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 7,584E-03 0,01208873 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 7,584E-03 0,01208036 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 7,584E-03 0,012072 ! positive regulation of neurological system process GO:0031646 28 19 0,000 7,584E-03 0,01206365 ! sarcomere organization GO:0045214 23 19 0,000 7,584E-03 0,01205531 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 7,584E-03 0,01204698 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 7,584E-03 0,01203867 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 7,584E-03 0,01203037 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 7,584E-03 0,01202208 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 7,584E-03 0,0120138 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 7,584E-03 0,01200553 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 7,584E-03 0,01199727 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 7,584E-03 0,01198903 ! protein stabilization GO:0050821 26 19 0,000 7,584E-03 0,01198079 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 7,982E-03 0,01260054 ! iron ion transport GO:0006826 37 20 0,000 7,982E-03 0,0125919 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 7,982E-03 0,01258327 ! glucosamine metabolic process GO:0006041 25 20 0,000 7,982E-03 0,01257465 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 7,982E-03 0,01256604 ! response to vitamin GO:0033273 29 20 0,000 7,982E-03 0,01255745 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 7,982E-03 0,01254887 ! hindlimb morphogenesis GO:0035137 32 20 0,000 7,982E-03 0,01254029 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 7,982E-03 0,01253173 ! spinal cord development GO:0021510 31 20 0,000 7,982E-03 0,01252319 ! response to ethanol GO:0045471 37 20 0,000 7,982E-03 0,01251465 ! multicellular organismal response to stress GO:0033555 32 20 0,000 7,982E-03 0,01250612 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 7,982E-03 0,01249761 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 7,982E-03 0,01248911 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 7,982E-03 0,01248062 ! chromosome condensation GO:0030261 31 20 0,000 7,982E-03 0,01247214 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 7,982E-03 0,01246367 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 7,982E-03 0,01245522 ! determination of left/right symmetry GO:0007368 23 20 0,000 7,982E-03 0,01244677 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 7,982E-03 0,01243834 ! pallium development GO:0021543 38 20 0,000 7,982E-03 0,01242992 ! DNA modification GO:0006304 28 20 0,000 7,982E-03 0,01242151 ! positive regulation of locomotion GO:0040017 35 20 0,000 7,982E-03 0,01241311 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 7,982E-03 0,01240472 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 7,982E-03 0,01239635 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 7,982E-03 0,01238798 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 7,982E-03 0,01237963 ! positive regulation of B cell activation GO:0050871 31 20 0,000 7,982E-03 0,01237129 ! collagen catabolic process GO:0030574 25 20 0,000 7,982E-03 0,01236296 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 7,982E-03 0,01235464 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 7,982E-03 0,01234633 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 7,982E-03 0,01233803 ! alditol metabolic process GO:0019400 24 20 0,000 7,982E-03 0,01232974 ! actin filament-based movement GO:0030048 34 20 0,000 7,982E-03 0,01232147 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 8,38E-03 0,01292665 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 8,38E-03 0,01291798 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 8,38E-03 0,01290933 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 8,38E-03 0,01290069 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 8,38E-03 0,01289206 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 8,38E-03 0,01288344 ! determination of bilateral symmetry GO:0009855 25 21 0,000 8,38E-03 0,01287484 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 8,38E-03 0,01286624 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 8,38E-03 0,01285766 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 8,38E-03 0,01284909 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 8,38E-03 0,01284053 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 8,38E-03 0,01283198 ! protein amino acid acylation GO:0043543 37 21 0,000 8,38E-03 0,01282344 ! regulation of chemotaxis GO:0050920 36 21 0,000 8,38E-03 0,01281492 ! vesicle docking GO:0048278 27 21 0,000 8,38E-03 0,0128064 ! phototransduction GO:0007602 25 21 0,000 8,38E-03 0,0127979 ! dendrite development GO:0016358 35 21 0,000 8,38E-03 0,0127894 ! visual behavior GO:0007632 39 21 0,000 8,38E-03 0,01278092 ! regulation of DNA recombination GO:0000018 40 21 0,000 8,38E-03 0,01277245 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 8,38E-03 0,01276399 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 8,38E-03 0,01275555 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 8,38E-03 0,01274711 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 8,38E-03 0,01273869 ! cell aging GO:0007569 32 21 0,000 8,38E-03 0,01273027 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 8,38E-03 0,01272187 ! regulation of insulin secretion GO:0050796 26 21 0,000 8,38E-03 0,01271348 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 8,38E-03 0,0127051 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 8,38E-03 0,01269673 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 8,38E-03 0,01268837 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 8,38E-03 0,01268002 ! leukotriene metabolic process GO:0006691 28 21 0,000 8,38E-03 0,01267168 ! regulation of vasoconstriction GO:0019229 31 21 0,000 8,38E-03 0,01266336 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 8,38E-03 0,01265504 ! fatty acid transport GO:0015908 30 21 0,000 8,38E-03 0,01264674 ! immunoglobulin production GO:0002377 33 21 0,000 8,38E-03 0,01263845 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 8,38E-03 0,01263017 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 8,38E-03 0,01262189 ! positive regulation of protein secretion GO:0050714 26 21 0,000 8,38E-03 0,01261363 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 8,38E-03 0,01260538 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 8,38E-03 0,01259715 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 8,38E-03 0,01258892 ! regulation of bone mineralization GO:0030500 29 21 0,000 8,38E-03 0,0125807 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 8,38E-03 0,01257249 ! response to cytokine stimulus GO:0034097 47 21 0,000 8,38E-03 0,0125643 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 8,38E-03 0,01255611 ! porphyrin metabolic process GO:0006778 35 21 0,000 8,38E-03 0,01254794 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 8,38E-03 0,01253977 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 8,38E-03 0,01253162 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 8,38E-03 0,01252348 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 8,38E-03 0,01251535 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 8,777E-03 0,01310056 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 8,777E-03 0,01309206 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 8,777E-03 0,01308358 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 8,777E-03 0,0130751 ! viral genome replication GO:0019079 29 22 0,000 8,777E-03 0,01306664 ! regulation of transmembrane transport GO:0034762 30 22 0,000 8,777E-03 0,01305819 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 8,777E-03 0,01304975 ! leukocyte adhesion GO:0007159 38 22 0,000 8,777E-03 0,01304132 ! molting cycle process GO:0022404 40 22 0,000 8,777E-03 0,0130329 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 8,777E-03 0,01302449 ! glutamate signaling pathway GO:0007215 34 22 0,000 8,777E-03 0,01301609 ! macromolecular complex disassembly GO:0032984 38 22 0,000 8,777E-03 0,01300771 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 8,777E-03 0,01299933 ! vasculogenesis GO:0001570 33 22 0,000 8,777E-03 0,01299097 ! microtubule organizing center organization GO:0031023 28 22 0,000 8,777E-03 0,01298261 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 8,777E-03 0,01297427 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 8,777E-03 0,01296593 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 8,777E-03 0,01295761 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 8,777E-03 0,0129493 ! lysosome organization GO:0007040 37 22 0,000 8,777E-03 0,012941 ! barbed-end actin filament capping GO:0051016 33 22 0,000 8,777E-03 0,01293271 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 8,777E-03 0,01292443 ! coenzyme catabolic process GO:0009109 33 22 0,000 8,777E-03 0,01291616 ! regulation of behavior GO:0050795 38 22 0,000 8,777E-03 0,0129079 ! vitamin biosynthetic process GO:0009110 24 22 0,000 8,777E-03 0,01289966 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 8,777E-03 0,01289142 ! membrane depolarization GO:0051899 35 22 0,000 8,777E-03 0,01288319 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 8,777E-03 0,01287497 ! leukocyte homeostasis GO:0001776 33 22 0,000 8,777E-03 0,01286677 ! regulation of blood coagulation GO:0030193 34 22 0,000 8,777E-03 0,01285857 ! cellular alkene metabolic process GO:0043449 29 22 0,000 8,777E-03 0,01285039 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 8,777E-03 0,01284221 ! blastocyst development GO:0001824 37 22 0,000 8,777E-03 0,01283405 ! neural tube closure GO:0001843 33 22 0,000 8,777E-03 0,0128259 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 8,777E-03 0,01281775 ! protein tetramerization GO:0051262 39 22 0,000 8,777E-03 0,01280962 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 9,175E-03 0,01338109 ! neuron fate commitment GO:0048663 32 23 0,000 9,175E-03 0,01337261 ! embryonic pattern specification GO:0009880 31 23 0,000 9,175E-03 0,01336414 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 9,175E-03 0,01335568 ! myelination GO:0042552 35 23 0,000 9,175E-03 0,01334723 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 9,175E-03 0,0133388 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 9,175E-03 0,01333037 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 9,175E-03 0,01332195 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 9,175E-03 0,01331355 ! negative regulation of DNA replication GO:0008156 35 23 0,000 9,175E-03 0,01330515 ! vesicle targeting GO:0006903 32 23 0,000 9,175E-03 0,01329677 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 9,175E-03 0,0132884 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 9,175E-03 0,01328003 ! osteoblast differentiation GO:0001649 40 23 0,000 9,175E-03 0,01327168 ! regulation of viral reproduction GO:0050792 32 23 0,000 9,175E-03 0,01326334 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 9,175E-03 0,01325501 ! interaction with host GO:0051701 37 23 0,000 9,175E-03 0,01324669 ! lymphocyte proliferation GO:0046651 36 23 0,000 9,175E-03 0,01323838 ! regulation of biomineral formation GO:0070167 31 23 0,000 9,175E-03 0,01323008 ! cellular response to oxidative stress GO:0034599 33 23 0,000 9,175E-03 0,01322179 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 9,175E-03 0,01321351 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 9,175E-03 0,01320524 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 9,175E-03 0,01319698 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 9,175E-03 0,01318873 ! cell fate determination GO:0001709 45 23 0,000 9,175E-03 0,0131805 ! pentose metabolic process GO:0019321 31 23 0,000 9,175E-03 0,01317227 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 9,175E-03 0,01316405 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 9,175E-03 0,01315584 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 9,175E-03 0,01314765 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 9,175E-03 0,01313946 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 9,175E-03 0,01313128 ! telomere organization GO:0032200 32 23 0,000 9,175E-03 0,01312312 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 9,175E-03 0,01311496 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 9,175E-03 0,01310682 ! regulation of amine transport GO:0051952 38 23 0,000 9,175E-03 0,01309868 ! liver development GO:0001889 40 23 0,000 9,175E-03 0,01309055 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 9,572E-03 0,0136489 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 9,572E-03 0,01364044 ! initiation of viral infection GO:0019059 42 24 0,000 9,572E-03 0,013632 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 9,572E-03 0,01362356 ! pyruvate metabolic process GO:0006090 29 24 0,000 9,572E-03 0,01361514 ! superoxide metabolic process GO:0006801 32 24 0,000 9,572E-03 0,01360672 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 9,572E-03 0,01359832 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 9,572E-03 0,01358992 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 9,572E-03 0,01358154 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 9,572E-03 0,01357317 ! sperm motility GO:0030317 27 24 0,000 9,572E-03 0,0135648 ! mitochondrial membrane organization GO:0007006 39 24 0,000 9,572E-03 0,01355645 ! vacuole organization GO:0007033 39 24 0,000 9,572E-03 0,01354811 ! receptor metabolic process GO:0043112 37 24 0,000 9,572E-03 0,01353978 ! neural crest cell development GO:0014032 39 24 0,000 9,572E-03 0,01353145 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 9,572E-03 0,01352314 ! primary neural tube formation GO:0014020 35 24 0,000 9,572E-03 0,01351484 ! negative regulation of cell development GO:0010721 56 24 0,000 9,572E-03 0,01350655 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 9,572E-03 0,01349827 ! base-excision repair GO:0006284 31 24 0,000 9,572E-03 0,01349 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 9,572E-03 0,01348174 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 9,572E-03 0,01347348 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 9,572E-03 0,01346524 ! glutathione metabolic process GO:0006749 29 24 0,000 9,572E-03 0,01345701 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 9,572E-03 0,01344879 ! neurotransmitter secretion GO:0007269 32 24 0,000 9,572E-03 0,01344058 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 9,572E-03 0,01343238 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 9,969E-03 0,01398113 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 9,969E-03 0,01397261 ! amino sugar metabolic process GO:0006040 31 25 0,000 9,969E-03 0,0139641 ! protein amino acid alkylation GO:0008213 39 25 0,000 9,969E-03 0,01395561 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 9,969E-03 0,01394712 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 9,969E-03 0,01393864 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 9,969E-03 0,01393017 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 9,969E-03 0,01392171 ! peptide transport GO:0015833 43 25 0,000 9,969E-03 0,01391326 ! male gonad development GO:0008584 33 25 0,000 9,969E-03 0,01390483 ! iron ion homeostasis GO:0055072 39 25 0,000 9,969E-03 0,0138964 ! regulation of peptide secretion GO:0002791 34 25 0,000 9,969E-03 0,01388798 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 9,969E-03 0,01387958 ! regulation of chromosome organization GO:0033044 35 25 0,000 9,969E-03 0,01387118 ! phospholipid transport GO:0015914 35 25 0,000 9,969E-03 0,01386279 ! response to estradiol stimulus GO:0032355 34 25 0,000 9,969E-03 0,01385442 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 9,969E-03 0,01384605 ! detection of light stimulus GO:0009583 30 25 0,000 9,969E-03 0,01383769 ! positive regulation of nuclear division GO:0051785 39 25 0,000 9,969E-03 0,01382935 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 9,969E-03 0,01382101 ! leukocyte proliferation GO:0070661 39 25 0,000 9,969E-03 0,01381269 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 9,969E-03 0,01380437 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,01036614 0,01434545 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,01036614 0,01433682 ! translational initiation GO:0006413 43 26 0,000 0,01036614 0,0143282 ! regulation of pH GO:0006885 36 26 0,000 0,01036614 0,0143196 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,01036614 0,014311 ! circadian rhythm GO:0007623 42 26 0,000 0,01036614 0,01430242 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,01036614 0,01429384 ! post-embryonic development GO:0009791 42 26 0,000 0,01036614 0,01428528 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,01036614 0,01427673 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,01036614 0,01426818 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,01036614 0,01425965 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,01036614 0,01425113 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,01036614 0,01424261 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,01036614 0,01423411 GO:0046496|nicotinamide nucleotide metabolic process, ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,01036614 0,01422562 ! regulation of coagulation GO:0050818 39 26 0,000 0,01036614 0,01421713 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,010763 0,01475262 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,010763 0,01474383 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,010763 0,01473505 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,010763 0,01472629 ! membrane docking GO:0022406 39 27 0,000 0,010763 0,01471753 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,010763 0,01470879 ! catechol metabolic process GO:0009712 43 27 0,000 0,010763 0,01470005 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,010763 0,01469133 ! acute-phase response GO:0006953 42 27 0,000 0,010763 0,01468262 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,010763 0,01467391 ! myofibril assembly GO:0030239 36 27 0,000 0,010763 0,01466522 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,010763 0,01465654 ! response to ionizing radiation GO:0010212 47 27 0,000 0,010763 0,01464786 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,010763 0,0146392 ! natural killer cell activation GO:0030101 35 27 0,000 0,010763 0,01463055 ! lipid oxidation GO:0034440 38 27 0,000 0,010763 0,01462191 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,010763 0,01461328 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,010763 0,01460466 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,010763 0,01459604 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,010763 0,01458744 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,010763 0,01457885 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,010763 0,01457027 ! gene silencing GO:0016458 41 27 0,000 0,010763 0,0145617 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,01115971 0,01508956 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,01115971 0,01508069 ! phenol metabolic process GO:0018958 44 28 0,000 0,01115971 0,01507183 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,01115971 0,01506299 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,01115971 0,01505416 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,01115971 0,01504533 ! cell junction assembly GO:0034329 56 28 0,000 0,01115971 0,01503652 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,01115971 0,01502771 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,01115971 0,01501892 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,01115971 0,01501014 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,01115971 0,01500136 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,01115971 0,0149926 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,01115971 0,01498385 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,01115971 0,01497511 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,01115971 0,01496638 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,01115971 0,01495765 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,01115971 0,01494894 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,01115971 0,01494024 ! mesoderm formation GO:0001707 46 28 0,000 0,01115971 0,01493155 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,01115971 0,01492287 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,01115971 0,0149142 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,01115971 0,01490554 ! ensheathment of neurons GO:0007272 43 28 0,000 0,01115971 0,01489689 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,01115971 0,01488825 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,01115971 0,01487961 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,01115971 0,01487099 ! neural tube formation GO:0001841 41 28 0,000 0,01115971 0,01486238 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,01115971 0,01485378 ! placenta development GO:0001890 37 28 0,000 0,01115971 0,01484519 ! regulation of B cell activation GO:0050864 42 28 0,000 0,01115971 0,01483661 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,01155629 0,01535498 ! regulation of innate immune response GO:0045088 38 29 0,000 0,01155629 0,01534611 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,01155629 0,01533726 ! protein targeting to membrane GO:0006612 53 29 0,000 0,01155629 0,01532841 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,01155629 0,01531958 ! mismatch repair GO:0006298 34 29 0,000 0,01155629 0,01531075 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,01155629 0,01530194 ! muscle cell development GO:0055001 38 29 0,000 0,01155629 0,01529313 ! formation of primary germ layer GO:0001704 48 29 0,000 0,01155629 0,01528434 ! telencephalon development GO:0021537 52 29 0,000 0,01155629 0,01527555 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,01155629 0,01526678 ! eye morphogenesis GO:0048592 51 29 0,000 0,01155629 0,01525802 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,01155629 0,01524926 ! tissue homeostasis GO:0001894 42 29 0,000 0,01155629 0,01524052 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,01195273 0,01575432 ! collagen metabolic process GO:0032963 40 30 0,000 0,01195273 0,01574529 ! organic anion transport GO:0015711 51 30 0,000 0,01195273 0,01573628 ! cholesterol transport GO:0030301 46 30 0,000 0,01195273 0,01572728 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,01195273 0,01571829 ! spliceosome assembly GO:0000245 49 30 0,000 0,01195273 0,0157093 ! spindle organization GO:0007051 37 30 0,000 0,01195273 0,01570033 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,01195273 0,01569137 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,01195273 0,01568242 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,01195273 0,01567348 ! ceramide metabolic process GO:0006672 43 30 0,000 0,01195273 0,01566455 ! hindbrain development GO:0030902 45 30 0,000 0,01195273 0,01565563 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,01195273 0,01564672 ! adult locomotory behavior GO:0008344 47 30 0,000 0,01195273 0,01563782 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,01195273 0,01562893 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,01195273 0,01562005 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,01195273 0,01561118 ! response to heat GO:0009408 41 30 0,000 0,01195273 0,01560232 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,01195273 0,01559347 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,01195273 0,01558463 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,01234904 0,01609223 ! negative regulation of secretion GO:0051048 49 31 0,000 0,01234904 0,01608312 ! mammary gland development GO:0030879 57 31 0,000 0,01234904 0,01607402 ! glial cell differentiation GO:0010001 55 31 0,000 0,01234904 0,01606492 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,01234904 0,01605584 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,01234904 0,01604677 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,01234904 0,01603771 ! odontogenesis GO:0042476 50 31 0,000 0,01234904 0,01602866 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,01234904 0,01601962 ! segmentation GO:0035282 41 31 0,000 0,01234904 0,01601059 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,01234904 0,01600157 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,01234904 0,01599256 ! metanephros development GO:0001656 58 31 0,000 0,01234904 0,01598356 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,01234904 0,01597457 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,01234904 0,01596559 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,01234904 0,01595662 ! cell fate specification GO:0001708 37 31 0,000 0,01234904 0,01594766 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,01234904 0,01593871 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,01234904 0,01592977 ! RNA modification GO:0009451 40 31 0,000 0,01234904 0,01592084 ! regulation of muscle development GO:0048634 48 32 0,000 0,01274521 0,0164224 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,01274521 0,0164132 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,01274521 0,01640402 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,01274521 0,01639484 ! meiosis I GO:0007127 52 32 0,000 0,01274521 0,01638568 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,01274521 0,01637652 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,01274521 0,01636738 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,01274521 0,01635825 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,01274521 0,01634912 ! peripheral nervous system development GO:0007422 53 32 0,000 0,01274521 0,01634001 ! regulation of protein stability GO:0031647 48 32 0,000 0,01274521 0,01633091 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,01274521 0,01632181 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,01274521 0,01631273 ! cytokine production GO:0001816 44 32 0,000 0,01274521 0,01630366 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,01274521 0,01629459 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,01274521 0,01628554 ! vesicle localization GO:0051648 47 32 0,000 0,01274521 0,0162765 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,01314124 0,01677295 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,01314124 0,01676365 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,01314124 0,01675435 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,01314124 0,01674507 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,01314124 0,0167358 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,01314124 0,01672654 ! sister chromatid segregation GO:0000819 46 33 0,000 0,01314124 0,01671729 ! ear morphogenesis GO:0042471 42 33 0,000 0,01314124 0,01670804 ! actomyosin structure organization GO:0031032 43 33 0,000 0,01314124 0,01669881 ! cell junction organization GO:0034330 63 33 0,000 0,01314124 0,01668959 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,01314124 0,01668038 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,01314124 0,01667118 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,01314124 0,01666199 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,01314124 0,01665281 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,01314124 0,01664364 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,01314124 0,01663448 ! positive regulation of cell development GO:0010720 54 33 0,000 0,01314124 0,01662533 ! lipid homeostasis GO:0055088 55 33 0,000 0,01314124 0,01661619 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,01314124 0,01660706 ! regulation of proteolysis GO:0030162 50 33 0,000 0,01314124 0,01659794 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,01314124 0,01658883 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,01314124 0,01657973 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,01314124 0,01657064 ! cytokinesis GO:0000910 52 33 0,000 0,01314124 0,01656156 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,01314124 0,01655249 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,01353714 0,01704183 ! mRNA catabolic process GO:0006402 48 34 0,000 0,01353714 0,0170325 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,01353714 0,01702319 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,01353714 0,01701389 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,01353714 0,0170046 ! feeding behavior GO:0007631 45 34 0,000 0,01353714 0,01699531 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,01353714 0,01698604 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,01353714 0,01697678 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,01353714 0,01696753 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,01353714 0,01695829 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,01353714 0,01694906 ! neuron migration GO:0001764 46 34 0,000 0,01353714 0,01693984 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,01353714 0,01693062 ! female gamete generation GO:0007292 43 34 0,000 0,01353714 0,01692142 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,01353714 0,01691223 ! polyol metabolic process GO:0019751 44 34 0,000 0,01353714 0,01690305 ! aerobic respiration GO:0009060 47 34 0,000 0,01353714 0,01689388 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,01353714 0,01688472 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,01353714 0,01687556 ! embryonic organ development GO:0048568 45 34 0,000 0,01353714 0,01686642 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,01353714 0,01685729 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,0139329 0,01734073 ! Notch signaling pathway GO:0007219 56 35 0,000 0,0139329 0,01733135 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,0139329 0,01732198 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,0139329 0,01731262 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,0139329 0,01730328 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,0139329 0,01729394 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,0139329 0,01728461 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,0139329 0,01727529 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,0139329 0,01726598 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,0139329 0,01725669 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,0139329 0,0172474 ! glycogen metabolic process GO:0005977 48 35 0,000 0,0139329 0,01723812 ! pigment metabolic process GO:0042440 61 35 0,000 0,0139329 0,01722885 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,0139329 0,0172196 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,0139329 0,01721035 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,01432852 0,01768954 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,01432852 0,01768005 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,01432852 0,01767057 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,01432852 0,0176611 ! negative regulation of binding GO:0051100 58 36 0,000 0,01432852 0,01765164 ! organic ether metabolic process GO:0018904 46 36 0,000 0,01432852 0,01764219 ! tissue remodeling GO:0048771 62 36 0,000 0,01432852 0,01763275 ! neural tube development GO:0021915 50 36 0,000 0,01432852 0,01762332 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,01432852 0,0176139 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,01432852 0,01760449 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,01432852 0,01759509 ! glucan metabolic process GO:0044042 49 36 0,000 0,01432852 0,0175857 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,01472401 0,01806146 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,01472401 0,01805183 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,01472401 0,01804221 ! learning GO:0007612 67 37 0,000 0,01472401 0,0180326 ! ion transmembrane transport GO:0034220 56 37 0,000 0,01472401 0,01802301 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,01472401 0,01801342 ! regulation of protein secretion GO:0050708 51 37 0,000 0,01472401 0,01800384 ! amino acid activation GO:0043038 52 37 0,000 0,01472401 0,01799428 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,01472401 0,01798472 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,01511937 0,01845782 ! gliogenesis GO:0042063 71 38 0,000 0,01511937 0,01844803 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,01511937 0,01843825 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,01511937 0,01842848 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,01511937 0,01841872 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,01511937 0,01840897 ! phagocytosis GO:0006909 60 38 0,000 0,01511937 0,01839923 ! mesenchymal cell development GO:0014031 64 38 0,000 0,01511937 0,0183895 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,01511937 0,01837978 ! maintenance of location in cell GO:0051651 69 38 0,000 0,01511937 0,01837007 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,01551458 0,01884031 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,01551458 0,01883036 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,01551458 0,01882043 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,01551458 0,01881051 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,01551458 0,0188006 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,01551458 0,0187907 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,01551458 0,01878081 ! male sex differentiation GO:0046661 53 39 0,000 0,01551458 0,01877093 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,01551458 0,01876106 ! chromatin remodeling GO:0006338 68 39 0,000 0,01551458 0,0187512 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,01551458 0,01874136 ! JNK cascade GO:0007254 54 39 0,000 0,01551458 0,01873152 ! developmental growth GO:0048589 62 39 0,000 0,01551458 0,01872169 ! cell growth GO:0016049 61 39 0,000 0,01551458 0,01871187 ! synapse organization GO:0050808 55 39 0,000 0,01551458 0,01870207 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,01590966 0,01916827 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,01590966 0,01915823 ! regulation of tube size GO:0035150 60 40 0,000 0,01590966 0,01914821 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,01590966 0,01913819 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,01590966 0,01912819 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,01590966 0,0191182 ! peptide metabolic process GO:0006518 56 40 0,000 0,01590966 0,01910821 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,01590966 0,01909824 ! inner ear development GO:0048839 57 40 0,000 0,01590966 0,01908828 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,01590966 0,01907832 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,01590966 0,01906838 ! B cell differentiation GO:0030183 62 40 0,000 0,01590966 0,01905845 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,01590966 0,01904853 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,01590966 0,01903862 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,01590966 0,01902872 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,01590966 0,01901883 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,01630461 0,01948083 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,01630461 0,01947072 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,01630461 0,01946061 ! glucose transport GO:0015758 52 41 0,000 0,01630461 0,01945052 ! endosome transport GO:0016197 71 41 0,000 0,01630461 0,01944044 ! striated muscle contraction GO:0006941 62 41 0,000 0,01630461 0,01943036 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,01630461 0,0194203 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,01630461 0,01941025 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,01630461 0,01940021 ! biopolymer methylation GO:0043414 62 41 0,000 0,01630461 0,01939018 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,01630461 0,01938016 ! mitochondrial transport GO:0006839 60 42 0,000 0,01669942 0,01983918 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,01669942 0,01982894 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,01669942 0,01981871 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,01669942 0,01980849 ! cellular component disassembly GO:0022411 64 42 0,000 0,01669942 0,01979828 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,01669942 0,01978808 ! hexose transport GO:0008645 54 42 0,000 0,01669942 0,01977789 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,01669942 0,01976771 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,01669942 0,01975754 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,01669942 0,01974738 ! excretion GO:0007588 63 42 0,000 0,01669942 0,01973724 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,01669942 0,0197271 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,01669942 0,01971697 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,01669942 0,01970686 ! regulation of cell shape GO:0008360 78 42 0,000 0,01669942 0,01969675 ! positive regulation of binding GO:0051099 59 43 0,000 0,01709409 0,02015193 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,01709409 0,0201416 ! leukocyte migration GO:0050900 60 43 0,000 0,01709409 0,02013129 ! neuromuscular process GO:0050905 79 43 0,000 0,01709409 0,02012099 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,01709409 0,0201107 ! tRNA processing GO:0008033 49 43 0,000 0,01709409 0,02010041 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,01709409 0,02009014 ! vesicle organization GO:0016050 79 43 0,000 0,01709409 0,02007988 ! response to insulin stimulus GO:0032868 63 43 0,000 0,01709409 0,02006963 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,01709409 0,02005939 ! methylation GO:0032259 64 43 0,000 0,01709409 0,02004916 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,01748863 0,02050145 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,01748863 0,02049101 ! glycolysis GO:0006096 53 44 0,000 0,01748863 0,02048057 ! regulation of action potential GO:0001508 71 44 0,000 0,01748863 0,02047015 ! regulation of ion transport GO:0043269 57 44 0,000 0,01748863 0,02045974 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,01748863 0,02044934 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,01748863 0,02043895 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,01748863 0,02042857 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,01748863 0,0204182 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,01748863 0,02040784 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,01748863 0,02039749 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,01748863 0,02038715 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,01748863 0,02037682 ! RNA catabolic process GO:0006401 64 45 0,000 0,01788303 0,02082581 ! positive regulation of defense response GO:0031349 59 45 0,000 0,01788303 0,02081527 ! regulation of translational initiation GO:0006446 64 45 0,000 0,01788303 0,02080474 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,01788303 0,02079422 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,01788303 0,02078371 ! cell recognition GO:0008037 58 45 0,000 0,01788303 0,02077322 ! cell maturation GO:0048469 60 45 0,000 0,01788303 0,02076273 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,01788303 0,02075226 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,0182773 0,02119908 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,0182773 0,0211884 ! cell redox homeostasis GO:0045454 63 46 0,000 0,0182773 0,02117772 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,0182773 0,02116706 ! regulation of ossification GO:0030278 71 46 0,000 0,0182773 0,02115641 ! histone modification GO:0016570 68 46 0,000 0,0182773 0,02114577 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,0182773 0,02113513 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,01867143 0,02158004 ! viral infectious cycle GO:0019058 71 47 0,000 0,01867143 0,0215692 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,01867143 0,02155838 ! endocrine system development GO:0035270 83 47 0,000 0,01867143 0,02154756 ! covalent chromatin modification GO:0016569 75 47 0,000 0,01867143 0,02153675 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,01867143 0,02152596 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,01867143 0,02151517 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,01867143 0,0215044 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,01867143 0,02149364 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,01867143 0,02148288 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,01867143 0,02147214 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,01867143 0,02146141 ! chloride transport GO:0006821 67 48 0,000 0,01906542 0,02190333 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,01906542 0,0218924 ! response to temperature stimulus GO:0009266 62 48 0,000 0,01906542 0,02188147 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,01906542 0,02187056 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,01906542 0,02185966 ! gastrulation GO:0007369 73 48 0,000 0,01906542 0,02184877 ! heart morphogenesis GO:0003007 65 48 0,000 0,01906542 0,02183788 ! regulation of DNA replication GO:0006275 75 48 0,000 0,01906542 0,02182701 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,01906542 0,02181615 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,01906542 0,02180531 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,01906542 0,02179447 ! regulation of endocytosis GO:0030100 63 48 0,000 0,01906542 0,02178364 ! nuclear export GO:0051168 69 48 0,000 0,01906542 0,02177283 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,01906542 0,02176202 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,01906542 0,02175123 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,01945928 0,02218956 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,01945928 0,02217857 ! sensory perception of smell GO:0007608 61 49 0,000 0,01945928 0,02216758 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,01945928 0,02215661 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,01945928 0,02214564 ! RNA elongation GO:0006354 62 49 0,000 0,01945928 0,02213469 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,01945928 0,02212375 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,01945928 0,02211282 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,01945928 0,0221019 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,01945928 0,02209099 ! cartilage development GO:0051216 70 49 0,000 0,01945928 0,02208009 ! maintenance of location GO:0051235 84 49 0,000 0,01945928 0,0220692 ! regulation of actin filament length GO:0030832 72 50 0,000 0,01985301 0,02250464 ! ear development GO:0043583 72 50 0,000 0,01985301 0,02249355 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,01985301 0,02248248 ! membrane fusion GO:0006944 80 50 0,000 0,01985301 0,02247141 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,01985301 0,02246036 ! lipid modification GO:0030258 73 50 0,000 0,01985301 0,02244932 ! positive regulation of growth GO:0045927 67 50 0,000 0,01985301 0,02243829 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,01985301 0,02242727 ! proton transport GO:0015992 75 50 0,000 0,01985301 0,02241626 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,01985301 0,02240526 ! positive regulation of secretion GO:0051047 71 51 0,000 0,02024659 0,02283824 ! hydrogen transport GO:0006818 77 51 0,000 0,02024659 0,02282704 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,02024659 0,02281586 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,02024659 0,02280468 ! positive regulation of cell migration GO:0030335 92 51 0,000 0,02024659 0,02279352 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,02024659 0,02278237 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,02024659 0,02277123 ! adult behavior GO:0030534 80 51 0,000 0,02024659 0,0227601 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,02024659 0,02274898 ! transition metal ion transport GO:0000041 74 52 0,000 0,02064005 0,02317974 ! regulation of cellular component size GO:0032535 74 52 0,000 0,02064005 0,02316843 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,02064005 0,02315712 ! aging GO:0007568 79 52 0,000 0,02064005 0,02314583 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,02064005 0,02313455 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,02064005 0,02312329 ! establishment of organelle localization GO:0051656 85 52 0,000 0,02064005 0,02311203 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,02103336 0,02354099 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,02103336 0,02352954 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,02103336 0,0235181 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,02103336 0,02350667 ! kidney development GO:0001822 90 53 0,000 0,02103336 0,02349526 ! single fertilization GO:0007338 59 53 0,000 0,02103336 0,02348385 ! cell projection assembly GO:0030031 76 53 0,000 0,02103336 0,02347246 ! amino acid transport GO:0006865 84 54 0,000 0,02142655 0,02389964 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,02142655 0,02388805 ! regulation of mitosis GO:0007088 84 54 0,000 0,02142655 0,02387648 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,02142655 0,02386492 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,02142655 0,02385337 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,02142655 0,02384183 ! DNA catabolic process GO:0006308 67 54 0,000 0,02142655 0,0238303 ! detection of external stimulus GO:0009581 66 54 0,000 0,02142655 0,02381878 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,02142655 0,02380727 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,02142655 0,02379578 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,02142655 0,02378429 ! exocytosis GO:0006887 74 55 0,000 0,02181959 0,02420891 ! mesoderm development GO:0007498 76 55 0,000 0,02181959 0,02419723 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,02181959 0,02418557 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,02181959 0,02417392 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,0222125 0,02459738 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,0222125 0,02458554 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,0222125 0,02457372 ! positive regulation of cell motion GO:0051272 99 56 0,000 0,0222125 0,0245619 ! negative regulation of protein kinase activity GO:0006469 99 57 0,000 0,02260528 0,02498421 ! carbohydrate transport GO:0008643 74 57 0,000 0,02260528 0,02497221 ! chromosome segregation GO:0007059 83 57 0,000 0,02260528 0,02496022 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,02260528 0,02494824 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,02260528 0,02493628 ! camera-type eye development GO:0043010 88 57 0,000 0,02260528 0,02492432 ! secondary metabolic process GO:0019748 84 57 0,000 0,02260528 0,02491238 ! response to peptide hormone stimulus GO:0043434 84 57 0,000 0,02260528 0,02490045 ! developmental maturation GO:0021700 75 57 0,000 0,02260528 0,02488853 ! negative regulation of kinase activity GO:0033673 100 58 0,000 0,02299792 0,02530872 ! viral reproductive process GO:0022415 87 58 0,000 0,02299792 0,02529661 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,02299792 0,02528452 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,02299792 0,02527244 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,02299792 0,02526037 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,02339042 0,02567923 ! activation of MAPK activity GO:0000187 84 59 0,000 0,02339042 0,02566697 ! lung development GO:0030324 94 59 0,000 0,02339042 0,02565473 ! actin filament organization GO:0007015 95 59 0,000 0,02339042 0,02564251 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,02339042 0,02563029 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,02339042 0,02561808 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,0237828 0,02603543 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,0237828 0,02602304 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,0237828 0,02601067 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,0237828 0,0259983 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,0237828 0,02598595 ! regulation of heart contraction GO:0008016 91 60 0,000 0,0237828 0,02597361 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,0237828 0,02596129 ! fertilization GO:0009566 68 60 0,000 0,0237828 0,02594897 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,0237828 0,02593667 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,02417503 0,02635193 ! meiosis GO:0007126 96 61 0,000 0,02417503 0,02633945 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,02417503 0,02632697 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,02417503 0,02631451 ! urogenital system development GO:0001655 101 61 0,000 0,02417503 0,02630207 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,02417503 0,02628963 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,02417503 0,02627721 ! extracellular matrix organization GO:0030198 103 61 0,000 0,02417503 0,02626479 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,02417503 0,02625239 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 0,000 0,02417503 0,02624 ! amine catabolic process GO:0009310 90 62 0,000 0,02456713 0,02665302 ! neurotransmitter transport GO:0006836 81 62 0,000 0,02456713 0,02664045 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,02456713 0,0266279 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,02456713 0,02661536 ! respiratory tube development GO:0030323 99 62 0,000 0,02456713 0,02660282 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,02456713 0,02659031 ! meiotic cell cycle GO:0051321 97 62 0,000 0,02456713 0,0265778 ! organelle localization GO:0051640 96 62 0,000 0,02456713 0,0265653 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,0249591 0,02697647 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,0249591 0,02696379 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,0249591 0,02695114 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,0249591 0,02693849 ! viral reproduction GO:0016032 92 63 0,000 0,0249591 0,02692585 ! regulation of lipase activity GO:0060191 109 63 0,000 0,0249591 0,02691323 ! negative regulation of cell size GO:0045792 108 64 0,000 0,02535093 0,02732293 ! appendage morphogenesis GO:0035107 93 64 0,000 0,02535093 0,02731013 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,02535093 0,02729734 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,02535093 0,02728457 ! hexose catabolic process GO:0019320 82 64 0,000 0,02535093 0,02727181 ! respiratory system development GO:0060541 100 64 0,000 0,02535093 0,02725906 ! adaptive immune response GO:0002250 94 64 0,000 0,02535093 0,02724632 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 0,000 0,02574262 0,02765438 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,02574262 0,02764147 ! defense response to bacterium GO:0042742 73 65 0,000 0,02574262 0,02762857 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,02574262 0,02761568 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,02574262 0,02760281 ! activation of immune response GO:0002253 83 65 0,000 0,02574262 0,02758995 ! protein oligomerization GO:0051259 100 65 0,000 0,02574262 0,0275771 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,02613418 0,02798353 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,02613418 0,0279705 ! antigen processing and presentation GO:0019882 96 66 0,000 0,02613418 0,0279575 ! axon guidance GO:0007411 99 66 0,000 0,02613418 0,0279445 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,02613418 0,02793151 ! regulation of immune effector process GO:0002697 101 66 0,000 0,02613418 0,02791854 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,02652561 0,02832353 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,02652561 0,02831039 ! acute inflammatory response GO:0002526 92 68 0,000 0,0269169 0,02871468 ! learning or memory GO:0007611 123 68 0,000 0,0269169 0,02870137 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,0269169 0,02868807 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,0269169 0,02867478 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,0269169 0,02866151 ! inorganic anion transport GO:0015698 93 68 0,000 0,0269169 0,02864825 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,02730805 0,02905112 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,02730805 0,02903769 ! response to drug GO:0042493 108 69 0,000 0,02730805 0,02902427 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,02769907 0,02942627 ! humoral immune response GO:0006959 86 70 0,000 0,02769907 0,02941268 ! eye development GO:0001654 111 70 0,000 0,02769907 0,02939911 ! amine transport GO:0015837 101 70 0,000 0,02769907 0,02938555 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,02769907 0,029372 ! regulation of catabolic process GO:0009894 106 70 0,000 0,02769907 0,02935846 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,02808996 0,02975905 ! muscle cell differentiation GO:0042692 104 71 0,000 0,02808996 0,02974535 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,02808996 0,02973166 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,02808996 0,02971799 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,02808996 0,02970432 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,02808996 0,02969067 ! response to hypoxia GO:0001666 132 72 0,000 0,02848071 0,03008986 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,02848071 0,03007605 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,02848071 0,03006224 ! negative regulation of transport GO:0051051 116 73 0,000 0,02887133 0,03046057 ! regulation of blood pressure GO:0008217 107 73 0,000 0,02887133 0,03044661 ! tube morphogenesis GO:0035239 118 73 0,000 0,02887133 0,03043265 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,02887133 0,03041871 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,02887133 0,03040478 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,02926181 0,0308019 ! response to oxygen levels GO:0070482 137 74 0,000 0,02926181 0,03078781 ! digestion GO:0007586 97 74 0,000 0,02926181 0,03077373 ! protein import into nucleus GO:0006606 118 74 0,000 0,02926181 0,03075967 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,02926181 0,03074562 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,02926181 0,03073158 ! blood coagulation GO:0007596 116 75 0,000 0,02965216 0,03112732 GO:0050817|coagulation, ! negative regulation of growth GO:0045926 123 75 0,000 0,02965216 0,03111312 ! response to nutrient GO:0007584 104 75 0,000 0,02965216 0,03109893 ! nuclear import GO:0051170 121 75 0,000 0,02965216 0,03108476 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,02965216 0,0310706 ! amine biosynthetic process GO:0009309 97 76 0,000 0,03004237 0,03146514 ! tRNA metabolic process GO:0006399 95 76 0,000 0,03004237 0,03145082 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,03004237 0,03143651 ! regulation of protein transport GO:0051223 114 76 0,000 0,03004237 0,03142221 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,03043245 0,03181574 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,03043245 0,03180128 ! regulation of DNA binding GO:0051101 119 77 0,000 0,03043245 0,03178684 ! gland development GO:0048732 148 77 0,000 0,03043245 0,03177241 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,03043245 0,031758 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,03043245 0,03174359 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,03043245 0,03172921 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,03082239 0,0321212 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,03082239 0,03210666 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,0312122 0,03249799 ! cellular respiration GO:0045333 107 79 0,000 0,0312122 0,03248328 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,0312122 0,03246859 ! T cell activation GO:0042110 134 79 0,000 0,0312122 0,03245391 ! regulation of lyase activity GO:0051339 133 79 0,000 0,0312122 0,03243925 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,0312122 0,0324246 ! chromatin assembly GO:0031497 102 80 0,000 0,03160187 0,03281459 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,03160187 0,03279978 ! protein localization in nucleus GO:0034504 133 80 0,000 0,03160187 0,03278498 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,03160187 0,0327702 ! forebrain development GO:0030900 131 80 0,000 0,03160187 0,03275544 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,03199142 0,03314426 ! hemostasis GO:0007599 125 81 0,000 0,03199142 0,03312934 ! mRNA transport GO:0051028 121 81 0,000 0,03199142 0,03311443 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,03199142 0,03309953 ! regulation of neurological system process GO:0031644 122 81 0,000 0,03199142 0,03308465 ! vitamin metabolic process GO:0006766 103 81 0,000 0,03199142 0,03306978 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,03199142 0,03305492 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,03238082 0,03344225 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,03238082 0,03342724 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,03277009 0,03381391 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,03277009 0,03379875 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,03277009 0,0337836 ! regulation of defense response GO:0031347 117 84 0,000 0,03315923 0,03416946 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,03315923 0,03415416 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,03315923 0,03413887 ! sterol metabolic process GO:0016125 120 84 0,000 0,03315923 0,03412359 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,03354824 0,03450847 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,03354824 0,03449304 ! rRNA metabolic process GO:0016072 107 85 0,000 0,03354824 0,03447763 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 0,000 0,03354824 0,03446223 ! transcription initiation GO:0006352 118 85 0,000 0,03354824 0,03444685 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,03354824 0,03443148 ! regulation of protein localization GO:0032880 132 85 0,000 0,03354824 0,03441612 ! regulation of membrane potential GO:0042391 128 85 0,000 0,03354824 0,03440078 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,03354824 0,03438545 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,0339371 0,03476853 ! cell cycle arrest GO:0007050 150 86 0,000 0,0339371 0,03475305 ! nucleosome organization GO:0034728 114 87 0,000 0,03432584 0,03513548 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,03432584 0,03511985 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,03432584 0,03510424 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,03432584 0,03508864 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,03432584 0,03507305 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,03432584 0,03505747 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,03471444 0,03543862 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,03471444 0,0354229 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,03471444 0,03540719 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,03471444 0,0353915 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,03471444 0,03537582 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,03510291 0,03575584 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,03510291 0,03574001 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,03510291 0,0357242 ! regulation of T cell activation GO:0050863 128 89 0,000 0,03510291 0,0357084 ! leukocyte differentiation GO:0002521 143 90 0,000 0,03549124 0,03608747 ! hormone metabolic process GO:0042445 121 90 0,000 0,03549124 0,03607152 ! RNA localization GO:0006403 135 91 0,000 0,03587944 0,03644996 ! ATP metabolic process GO:0046034 137 91 0,000 0,03587944 0,03643387 ! response to virus GO:0009615 122 91 0,000 0,03587944 0,03641779 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,03626751 0,03679544 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,03626751 0,03677922 ! cell fate commitment GO:0045165 141 92 0,000 0,03626751 0,03676301 ! positive regulation of immune response GO:0050778 121 92 0,000 0,03626751 0,03674681 ! DNA recombination GO:0006310 146 92 0,000 0,03626751 0,03673063 ! sulfur metabolic process GO:0006790 118 92 0,000 0,03626751 0,03671447 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,03665544 0,03709085 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,03665544 0,03707454 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,03665544 0,03705824 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,03665544 0,03704196 ! electron transport chain GO:0022900 123 94 0,000 0,03704324 0,03741741 ! response to oxidative stress GO:0006979 141 94 0,000 0,03704324 0,03740098 ! regulation of binding GO:0051098 151 95 0,000 0,0374309 0,03777581 ! angiogenesis GO:0001525 149 95 0,000 0,0374309 0,03775924 ! carboxylic acid transport GO:0046942 147 95 0,000 0,0374309 0,03774269 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,03781843 0,03811673 ! in utero embryonic development GO:0001701 147 96 0,000 0,03781843 0,03810004 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,03781843 0,03808336 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,03781843 0,03806669 ! protein maturation GO:0051604 129 96 0,000 0,03781843 0,03805004 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,03820583 0,038423 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,03820583 0,03840621 ! calcium ion transport GO:0006816 167 99 0,000 0,03898022 0,03916754 ! extracellular structure organization GO:0043062 156 99 0,000 0,03898022 0,03915044 ! protein import GO:0017038 156 99 0,000 0,03898022 0,03913335 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,03898022 0,03911627 ! regulation of translation GO:0006417 151 100 0,000 0,03936721 0,03948739 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,03936721 0,03947018 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,03936721 0,03945298 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,03936721 0,0394358 ! divalent metal ion transport GO:0070838 171 100 0,000 0,03936721 0,03941863 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,03936721 0,03940147 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,03936721 0,03938434 ! protein localization in organelle GO:0033365 161 100 0,000 0,03936721 0,03936721