pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-b1/out-0.05-06-0.01-300-run-b1//th1-pval-1e-01-08-th2-pval-1e-02-02-th3-pval-1e-01-01-run-b1/go_data/8772-10-real-IPC-NIBC-129-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! activation of pro-apoptotic gene products GO:0008633 51 23 2,000 1,071E-07 2,617E-04 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 1,178E-06 1,438E-03 ! regulation of hair follicle development GO:0051797 10 5 1,000 1,661E-06 1,353E-03 GO:0042634|regulation of hair cycle, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 2,000 2,997E-06 1,831E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 2,000 3,133E-06 1,531E-03 ! Golgi to plasma membrane transport GO:0006893 14 7 1,000 3,486E-06 1,42E-03 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 1,000 3,486E-06 1,217E-03 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 2,000 3,563E-06 1,088E-03 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 2,000 3,563E-06 9,672E-04 ! positive regulation of ligase activity GO:0051351 130 77 2,000 4,365E-06 1,066E-03 ! positive regulation of epidermis development GO:0045684 13 8 1,000 4,648E-06 1,032E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 2,000 4,716E-06 9,602E-04 ! regulation of ligase activity GO:0051340 147 84 2,000 5,676E-06 1,067E-03 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 2,000 7,712E-06 1,346E-03 GO:0010498|proteasomal protein catabolic process, ! regulation of epidermis development GO:0045682 19 13 1,000 1,293E-05 2,106E-03 ! induction of apoptosis via death domain receptors GO:0008625 23 17 1,000 2,252E-05 3,439E-03 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 1,000 4,563E-05 6,558E-03 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 4,959E-05 6,73E-03 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 2,998E-04 0,03855429 ! interphase of mitotic cell cycle GO:0051329 224 98 1,000 7,718E-04 0,09427514 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 2,108E-03 0,2452771 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 2,108E-03 0,23412814 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 2,108E-03 0,22394865 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 2,108E-03 0,21461746 ! positive regulation of helicase activity GO:0051096 12 5 0,000 2,108E-03 0,20603276 ! neuron fate determination GO:0048664 7 5 0,000 2,108E-03 0,19810842 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 2,108E-03 0,19077108 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 2,108E-03 0,18395782 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 2,108E-03 0,17761445 ! polyol transport GO:0015791 12 5 0,000 2,108E-03 0,17169397 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 2,108E-03 0,16615545 ! response to superoxide GO:0000303 10 5 0,000 2,108E-03 0,1609631 ! negative regulation of bone resorption GO:0045779 10 5 0,000 2,108E-03 0,15608543 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 2,108E-03 0,15149468 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 2,108E-03 0,14716626 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 2,108E-03 0,14307831 ! female meiosis GO:0007143 10 5 0,000 2,108E-03 0,13921133 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 2,108E-03 0,13554787 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 2,108E-03 0,13207228 ! hypothalamus development GO:0021854 9 5 0,000 2,108E-03 0,12877048 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 2,108E-03 0,12562973 ! cobalt ion transport GO:0006824 11 5 0,000 2,108E-03 0,12263855 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 2,108E-03 0,11978649 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 2,108E-03 0,11706407 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 2,108E-03 0,11446265 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 2,108E-03 0,11197433 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 2,108E-03 0,10959189 ! embryonic camera-type eye development GO:0031076 12 5 0,000 2,108E-03 0,10730873 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 2,108E-03 0,10511876 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 2,108E-03 0,10301638 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 2,108E-03 0,10099645 ! transposition GO:0032196 9 5 0,000 2,108E-03 0,09905421 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 2,108E-03 0,09718526 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 2,108E-03 0,09538554 ! negative chemotaxis GO:0050919 16 5 0,000 2,108E-03 0,09365126 ! positive regulation of histone modification GO:0031058 6 5 0,000 2,108E-03 0,09197891 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 2,108E-03 0,09036525 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 2,108E-03 0,08880722 ! behavioral response to pain GO:0048266 10 5 0,000 2,108E-03 0,08730202 ! clathrin coat assembly GO:0048268 15 5 0,000 2,108E-03 0,08584698 ! Notch receptor processing GO:0007220 11 5 0,000 2,108E-03 0,08443966 ! regulation of dopamine uptake GO:0051584 9 5 0,000 2,108E-03 0,08307773 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 2,108E-03 0,08175903 ! micturition GO:0060073 9 5 0,000 2,108E-03 0,08048155 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 2,108E-03 0,07924337 ! copulation GO:0007620 9 5 0,000 2,108E-03 0,07804271 ! glial cell fate commitment GO:0021781 14 5 0,000 2,108E-03 0,0768779 ! protein maturation by protein folding GO:0022417 14 5 0,000 2,108E-03 0,07574734 ! bioluminescence GO:0008218 9 5 0,000 2,108E-03 0,07464955 ! spermidine metabolic process GO:0008216 7 5 0,000 2,108E-03 0,07358313 ! regulation of potassium ion transport GO:0043266 10 5 0,000 2,108E-03 0,07254675 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 2,108E-03 0,07153915 ! apoptotic cell clearance GO:0043277 23 5 0,000 2,108E-03 0,07055916 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 2,108E-03 0,06960566 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 2,108E-03 0,06867759 ! lipoprotein particle clearance GO:0034381 10 5 0,000 2,108E-03 0,06777393 ! grooming behavior GO:0007625 6 5 0,000 2,108E-03 0,06689375 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 2,108E-03 0,06603614 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 2,108E-03 0,06520024 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 2,108E-03 0,06438524 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 2,108E-03 0,06359036 ! response to protozoan GO:0001562 13 5 0,000 2,108E-03 0,06281487 ! positive regulation of glycolysis GO:0045821 13 5 0,000 2,108E-03 0,06205806 ! lymph vessel development GO:0001945 10 5 0,000 2,108E-03 0,06131927 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 2,108E-03 0,06059787 ! endochondral ossification GO:0001958 17 5 0,000 2,108E-03 0,05989324 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 2,108E-03 0,05920482 ! single strand break repair GO:0000012 8 5 0,000 2,108E-03 0,05853203 ! parathyroid gland development GO:0060017 14 5 0,000 2,108E-03 0,05787437 ! anagen GO:0042640 7 5 0,000 2,108E-03 0,05723132 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 2,108E-03 0,05660241 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 2,108E-03 0,05598716 ! cytokine secretion GO:0050663 15 5 0,000 2,108E-03 0,05538515 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 2,108E-03 0,05479595 ! ceramide catabolic process GO:0046514 7 5 0,000 2,108E-03 0,05421915 ! skeletal myofibril assembly GO:0014866 12 5 0,000 2,108E-03 0,05365437 ! smooth muscle tissue development GO:0048745 32 5 0,000 2,108E-03 0,05310123 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 2,108E-03 0,05255938 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 2,108E-03 0,05202848 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 2,108E-03 0,05150819 ! cardiac muscle fiber development GO:0048739 12 5 0,000 2,108E-03 0,05099821 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 2,108E-03 0,05049823 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 2,108E-03 0,05000795 ! neutrophil mediated immunity GO:0002446 7 5 0,000 2,108E-03 0,04952711 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 2,108E-03 0,04905542 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 2,108E-03 0,04859263 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 2,108E-03 0,0481385 ! glycine biosynthetic process GO:0006545 7 5 0,000 2,108E-03 0,04769277 ! microvillus organization GO:0032528 8 5 0,000 2,108E-03 0,04725522 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 2,108E-03 0,04682563 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 2,108E-03 0,04640378 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 2,108E-03 0,04598946 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 2,108E-03 0,04558247 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 2,108E-03 0,04518262 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 2,108E-03 0,04478973 ! polyol catabolic process GO:0046174 9 5 0,000 2,108E-03 0,04440361 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 2,108E-03 0,04402409 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 2,108E-03 0,04365101 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 2,108E-03 0,04328419 ! muscle cell migration GO:0014812 8 5 0,000 2,108E-03 0,04292349 ! mitochondrial fission GO:0000266 8 5 0,000 2,108E-03 0,04256875 ! sister chromatid cohesion GO:0007062 15 5 0,000 2,108E-03 0,04221983 ! response to tumor necrosis factor GO:0034612 10 5 0,000 2,108E-03 0,04187658 ! mRNA transcription GO:0009299 10 5 0,000 2,108E-03 0,04153886 ! nerve growth factor processing GO:0032455 9 5 0,000 2,108E-03 0,04120655 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 2,108E-03 0,04087952 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 2,108E-03 0,04055763 ! anaerobic glycolysis GO:0019642 6 5 0,000 2,108E-03 0,04024077 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 2,108E-03 0,03992883 ! monocyte activation GO:0042117 10 5 0,000 2,108E-03 0,03962168 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 2,108E-03 0,03931923 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 2,108E-03 0,03902136 ! response to food GO:0032094 6 5 0,000 2,108E-03 0,03872796 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 2,108E-03 0,03843895 ! positive regulation of transporter activity GO:0032411 8 5 0,000 2,108E-03 0,03815422 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 2,108E-03 0,03787367 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 2,108E-03 0,03759722 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 2,108E-03 0,03732478 ! forebrain neuron development GO:0021884 13 5 0,000 2,108E-03 0,03705625 ! lipoprotein catabolic process GO:0042159 11 5 0,000 2,108E-03 0,03679156 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 2,108E-03 0,03653063 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 2,108E-03 0,03627337 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 2,108E-03 0,03601971 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 2,108E-03 0,03576958 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 2,108E-03 0,03552289 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 2,108E-03 0,03527958 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 2,108E-03 0,03503959 ! lipid glycosylation GO:0030259 7 5 0,000 2,108E-03 0,03480283 ! nucleobase transport GO:0015851 6 5 0,000 2,108E-03 0,03456926 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 2,108E-03 0,03433879 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 2,108E-03 0,03411138 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 2,108E-03 0,03388697 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 2,108E-03 0,03366548 ! basic amino acid transport GO:0015802 12 5 0,000 2,108E-03 0,03344688 ! cellular glucose homeostasis GO:0001678 6 5 0,000 2,108E-03 0,03323109 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 2,108E-03 0,03301807 ! actin nucleation GO:0045010 11 5 0,000 2,108E-03 0,03280776 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 2,108E-03 0,03260012 ! depurination GO:0045007 5 5 0,000 2,108E-03 0,03239509 ! depyrimidination GO:0045008 10 5 0,000 2,108E-03 0,03219262 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 2,108E-03 0,03199266 ! regulation of centrosome cycle GO:0046605 7 5 0,000 2,108E-03 0,03179518 ! G2/M transition checkpoint GO:0031576 8 5 0,000 2,108E-03 0,03160012 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 2,108E-03 0,03140743 ! zinc ion homeostasis GO:0055069 9 5 0,000 2,108E-03 0,03121709 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 2,108E-03 0,03102903 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 2,108E-03 0,03084323 ! forebrain morphogenesis GO:0048853 13 5 0,000 2,108E-03 0,03065964 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 2,108E-03 0,03047822 ! activated T cell proliferation GO:0050798 16 5 0,000 2,108E-03 0,03029894 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 2,108E-03 0,03012175 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 2,108E-03 0,02994662 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 2,108E-03 0,02977352 ! positive regulation of organ growth GO:0046622 6 5 0,000 2,108E-03 0,02960241 ! gamma-delta T cell activation GO:0046629 6 5 0,000 2,108E-03 0,02943325 ! response to arsenic GO:0046685 11 5 0,000 2,108E-03 0,02926602 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 2,108E-03 0,02910067 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 2,108E-03 0,02893719 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 2,108E-03 0,02877553 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 2,108E-03 0,02861566 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 2,108E-03 0,02845756 ! response to mercury ion GO:0046689 8 5 0,000 2,108E-03 0,0283012 ! response to cadmium ion GO:0046686 7 5 0,000 2,108E-03 0,02814655 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 2,108E-03 0,02799358 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 2,108E-03 0,02784227 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 2,108E-03 0,02769258 ! bile acid biosynthetic process GO:0006699 7 5 0,000 2,108E-03 0,02754449 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 2,108E-03 0,02739797 ! ganglioside catabolic process GO:0006689 12 5 0,000 2,108E-03 0,02725301 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 2,108E-03 0,02710957 ! decidualization GO:0046697 11 5 0,000 2,108E-03 0,02696764 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 2,108E-03 0,02682718 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 2,108E-03 0,02668818 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 2,108E-03 0,02655061 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 2,108E-03 0,02641446 ! embryonic cleavage GO:0040016 6 5 0,000 2,108E-03 0,02627969 ! peroxisome fission GO:0016559 5 5 0,000 2,108E-03 0,02614629 ! histone demethylation GO:0016577 13 5 0,000 2,108E-03 0,02601424 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 2,108E-03 0,02588351 ! mitotic recombination GO:0006312 9 5 0,000 2,108E-03 0,0257541 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 2,108E-03 0,02562597 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 2,108E-03 0,0254991 ! metaphase plate congression GO:0051310 7 5 0,000 2,108E-03 0,02537349 ! regulation of sterol transport GO:0032371 7 5 0,000 2,108E-03 0,02524911 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 2,108E-03 0,02512595 ! enteric nervous system development GO:0048484 8 5 0,000 2,108E-03 0,02500398 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 2,108E-03 0,02488318 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 2,108E-03 0,02476355 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 2,108E-03 0,02464507 ! muscle cell proliferation GO:0033002 12 5 0,000 2,108E-03 0,02452771 ! skeletal muscle regeneration GO:0043403 8 5 0,000 2,108E-03 0,02441146 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 2,108E-03 0,02429632 ! B cell homeostasis GO:0001782 13 5 0,000 2,108E-03 0,02418225 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 2,108E-03 0,02406925 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 2,108E-03 0,0239573 ! metaphase GO:0051323 11 5 0,000 2,108E-03 0,02384638 ! melatonin biosynthetic process GO:0030187 7 5 0,000 2,108E-03 0,02373649 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 2,108E-03 0,02362761 ! cellular response to nutrient GO:0031670 8 5 0,000 2,108E-03 0,02351972 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 2,108E-03 0,02341281 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 2,108E-03 0,02330687 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 2,108E-03 0,02320189 ! definitive hemopoiesis GO:0060216 14 5 0,000 2,108E-03 0,02309784 ! response to redox state GO:0051775 6 5 0,000 2,108E-03 0,02299473 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 2,108E-03 0,02289253 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 2,108E-03 0,02279123 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 2,108E-03 0,02269083 ! brown fat cell differentiation GO:0050873 7 5 0,000 2,108E-03 0,02259131 ! regulation of telomerase activity GO:0051972 7 5 0,000 2,108E-03 0,02249266 ! galactolipid metabolic process GO:0019374 7 5 0,000 2,108E-03 0,02239487 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 2,108E-03 0,02229792 ! porphyrin catabolic process GO:0006787 12 5 0,000 2,108E-03 0,02220181 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 2,108E-03 0,02210652 ! striatum development GO:0021756 14 5 0,000 2,108E-03 0,02201205 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 2,108E-03 0,02191838 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 2,108E-03 0,0218255 ! glial cell migration GO:0008347 10 5 0,000 2,108E-03 0,02173341 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 2,108E-03 0,0216421 ! neural plate morphogenesis GO:0001839 7 5 0,000 2,108E-03 0,02155154 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 2,108E-03 0,02146175 ! somatic stem cell maintenance GO:0035019 15 5 0,000 2,108E-03 0,02137269 ! T cell activation during immune response GO:0002286 9 5 0,000 2,108E-03 0,02128438 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 2,108E-03 0,02119679 ! negative regulation of lipase activity GO:0060192 8 5 0,000 2,108E-03 0,02110991 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 2,108E-03 0,02102375 ! neuroprotection GO:0043526 8 5 0,000 2,108E-03 0,02093829 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 2,108E-03 0,02085352 ! regulation of sensory perception GO:0051931 8 5 0,000 2,108E-03 0,02076943 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 2,108E-03 0,02068602 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 2,108E-03 0,02060328 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 2,108E-03 0,02052119 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 2,108E-03 0,02043976 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 2,108E-03 0,02035897 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 2,108E-03 0,02027882 ! sequestering of calcium ion GO:0051208 7 5 0,000 2,108E-03 0,02019929 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 2,108E-03 0,02012039 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 2,108E-03 0,0200421 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 2,108E-03 0,01996441 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 2,108E-03 0,01988733 ! spindle assembly GO:0051225 6 5 0,000 2,108E-03 0,01981084 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 2,108E-03 0,01973494 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 2,108E-03 0,01965961 ! protein palmitoylation GO:0018345 12 5 0,000 2,108E-03 0,01958486 ! drug metabolic process GO:0017144 7 5 0,000 2,108E-03 0,01951068 ! stem cell division GO:0017145 11 5 0,000 2,108E-03 0,01943705 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 2,108E-03 0,01936398 ! organ regeneration GO:0031100 7 5 0,000 2,108E-03 0,01929146 ! carnitine metabolic process GO:0009437 8 5 0,000 2,108E-03 0,01921947 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 2,108E-03 0,01914803 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 2,53E-03 0,02288802 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 2,53E-03 0,02280356 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 2,53E-03 0,02271973 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 2,53E-03 0,0226365 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 2,53E-03 0,02255389 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 2,53E-03 0,02247188 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 2,53E-03 0,02239046 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 2,53E-03 0,02230962 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 2,53E-03 0,02222937 ! response to oxygen radical GO:0000305 11 6 0,000 2,53E-03 0,0221497 ! positive regulation of axon extension GO:0045773 13 6 0,000 2,53E-03 0,02207059 ! myoblast cell fate commitment GO:0048625 18 6 0,000 2,53E-03 0,02199205 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 2,53E-03 0,02191406 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 2,53E-03 0,02183663 ! regulation of interferon-beta production GO:0032648 8 6 0,000 2,53E-03 0,02175974 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 2,53E-03 0,02168339 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 2,53E-03 0,02160757 ! forebrain regionalization GO:0021871 9 6 0,000 2,53E-03 0,02153228 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 2,53E-03 0,02145752 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 2,53E-03 0,02138327 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 2,53E-03 0,02130954 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 2,53E-03 0,02123631 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 2,53E-03 0,02116358 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 2,53E-03 0,02109135 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 2,53E-03 0,02101961 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 2,53E-03 0,02094836 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 2,53E-03 0,02087759 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 2,53E-03 0,02080729 ! malate metabolic process GO:0006108 13 6 0,000 2,53E-03 0,02073747 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 2,53E-03 0,02066811 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 2,53E-03 0,02059922 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 2,53E-03 0,02053078 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 2,53E-03 0,0204628 ! protein refolding GO:0042026 15 6 0,000 2,53E-03 0,02039527 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 2,53E-03 0,02032818 ! opsonization GO:0008228 8 6 0,000 2,53E-03 0,02026153 ! mating behavior GO:0007617 7 6 0,000 2,53E-03 0,02019531 ! erythrocyte maturation GO:0043249 8 6 0,000 2,53E-03 0,02012953 ! embryonic hemopoiesis GO:0035162 16 6 0,000 2,53E-03 0,02006417 ! protein amino acid dealkylation GO:0008214 15 6 0,000 2,53E-03 0,01999924 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 2,53E-03 0,01993473 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 2,53E-03 0,01987063 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 2,53E-03 0,01980694 ! response to interferon-gamma GO:0034341 16 6 0,000 2,53E-03 0,01974366 ! toxin metabolic process GO:0009404 11 6 0,000 2,53E-03 0,01968078 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 2,53E-03 0,0196183 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 2,53E-03 0,01955622 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 2,53E-03 0,01949453 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 2,53E-03 0,01943323 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 2,53E-03 0,01937231 ! cGMP-mediated signaling GO:0019934 14 6 0,000 2,53E-03 0,01931177 ! dorsal spinal cord development GO:0021516 10 6 0,000 2,53E-03 0,01925161 ! activation of MAPKKK activity GO:0000185 12 6 0,000 2,53E-03 0,01919182 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 2,53E-03 0,0191324 ! thymic T cell selection GO:0045061 16 6 0,000 2,53E-03 0,01907335 ! sphingoid catabolic process GO:0046521 8 6 0,000 2,53E-03 0,01901466 ! protein lipoylation GO:0009249 10 6 0,000 2,53E-03 0,01895634 ! transepithelial chloride transport GO:0030321 12 6 0,000 2,53E-03 0,01889837 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 2,53E-03 0,01884075 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 2,53E-03 0,01878348 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 2,53E-03 0,01872656 ! glutamate catabolic process GO:0006538 12 6 0,000 2,53E-03 0,01866999 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 2,53E-03 0,01861375 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 2,53E-03 0,01855786 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 2,53E-03 0,01850229 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 2,53E-03 0,01844706 ! hyperosmotic response GO:0006972 10 6 0,000 2,53E-03 0,01839216 ! L-serine biosynthetic process GO:0006564 7 6 0,000 2,53E-03 0,01833758 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 2,53E-03 0,01828333 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 2,53E-03 0,0182294 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 2,53E-03 0,01817578 ! urea metabolic process GO:0019627 7 6 0,000 2,53E-03 0,01812248 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 2,53E-03 0,01806949 ! neutrophil activation GO:0042119 7 6 0,000 2,53E-03 0,01801681 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 2,53E-03 0,01796444 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 2,53E-03 0,01791236 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 2,53E-03 0,01786059 ! paraxial mesoderm development GO:0048339 16 6 0,000 2,53E-03 0,01780912 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 2,53E-03 0,01775795 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 2,53E-03 0,01770707 ! neuron apoptosis GO:0051402 15 6 0,000 2,53E-03 0,01765647 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 2,53E-03 0,01760617 ! T cell mediated immunity GO:0002456 17 6 0,000 2,53E-03 0,01755615 ! negative regulation of platelet activation GO:0010544 9 6 0,000 2,53E-03 0,01750642 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 2,53E-03 0,01745697 ! carnitine transport GO:0015879 10 6 0,000 2,53E-03 0,01740779 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 2,53E-03 0,01735889 ! positive regulation of exocytosis GO:0045921 11 6 0,000 2,53E-03 0,01731027 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 2,53E-03 0,01726192 ! early endosome to late endosome transport GO:0045022 16 6 0,000 2,53E-03 0,01721383 ! 5S class rRNA transcription GO:0042791 13 6 0,000 2,53E-03 0,01716602 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 2,53E-03 0,01711846 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 2,53E-03 0,01707118 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 2,53E-03 0,01702415 ! sodium ion homeostasis GO:0055078 12 6 0,000 2,53E-03 0,01697738 ! establishment of spindle localization GO:0051293 16 6 0,000 2,53E-03 0,01693087 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 2,53E-03 0,01688461 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 2,53E-03 0,0168386 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 2,53E-03 0,01679284 ! response to UV-C GO:0010225 14 6 0,000 2,53E-03 0,01674733 ! astrocyte development GO:0014002 16 6 0,000 2,53E-03 0,01670207 ! protein targeting to lysosome GO:0006622 12 6 0,000 2,53E-03 0,01665705 ! purine base biosynthetic process GO:0009113 17 6 0,000 2,53E-03 0,01661227 ! interaction with symbiont GO:0051702 14 6 0,000 2,53E-03 0,01656774 ! regulation of dendrite development GO:0050773 16 6 0,000 2,53E-03 0,01652344 ! peptidyl-arginine modification GO:0018195 13 6 0,000 2,53E-03 0,01647938 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 2,53E-03 0,01643555 ! response to copper ion GO:0046688 10 6 0,000 2,53E-03 0,01639195 ! response to exogenous dsRNA GO:0043330 13 6 0,000 2,53E-03 0,01634859 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 2,53E-03 0,01630545 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 2,53E-03 0,01626254 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 2,53E-03 0,01621986 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 2,53E-03 0,0161774 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 2,53E-03 0,01613516 ! regulation of dopamine secretion GO:0014059 14 6 0,000 2,53E-03 0,01609314 ! nucleoside catabolic process GO:0009164 10 6 0,000 2,53E-03 0,01605134 ! hair follicle maturation GO:0048820 8 6 0,000 2,53E-03 0,01600976 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 2,53E-03 0,01596839 ! Schwann cell development GO:0014044 15 6 0,000 2,53E-03 0,01592723 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 2,53E-03 0,01588629 ! response to pheromone GO:0019236 6 6 0,000 2,53E-03 0,01584555 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 2,53E-03 0,01580503 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 2,53E-03 0,01576471 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 2,53E-03 0,01572459 ! base conversion or substitution editing GO:0016553 6 6 0,000 2,53E-03 0,01568468 ! subpallium development GO:0021544 15 6 0,000 2,53E-03 0,01564498 ! neural tube patterning GO:0021532 8 6 0,000 2,53E-03 0,01560547 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 2,53E-03 0,01556616 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 2,53E-03 0,01552705 ! maintenance of organ identity GO:0048496 9 6 0,000 2,53E-03 0,01548813 ! G2 phase GO:0051319 16 6 0,000 2,53E-03 0,01544941 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 2,53E-03 0,01541089 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 2,53E-03 0,01537255 ! oxygen homeostasis GO:0032364 10 6 0,000 2,53E-03 0,01533441 ! establishment of planar polarity GO:0001736 7 6 0,000 2,53E-03 0,01529645 ! regulation of mast cell activation GO:0033003 13 6 0,000 2,53E-03 0,01525868 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 2,53E-03 0,0152211 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 2,53E-03 0,0151837 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 2,53E-03 0,01514648 ! receptor internalization GO:0031623 11 6 0,000 2,53E-03 0,01510945 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 2,53E-03 0,0150726 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 2,53E-03 0,01503593 ! neutrophil homeostasis GO:0001780 11 6 0,000 2,53E-03 0,01499943 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 2,53E-03 0,01496311 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 2,53E-03 0,01492697 ! protein deubiquitination GO:0016579 16 6 0,000 2,53E-03 0,014891 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 2,53E-03 0,01485521 ! protein destabilization GO:0031648 9 6 0,000 2,53E-03 0,01481958 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 2,53E-03 0,01478413 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 2,53E-03 0,01474884 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 2,53E-03 0,01471373 ! regulation of viral transcription GO:0046782 11 6 0,000 2,53E-03 0,01467878 ! progesterone metabolic process GO:0042448 12 6 0,000 2,53E-03 0,01464399 ! negative regulation of axon extension GO:0030517 24 6 0,000 2,53E-03 0,01460938 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 2,53E-03 0,01457492 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 2,53E-03 0,01454063 ! triglyceride catabolic process GO:0019433 10 6 0,000 2,53E-03 0,01450649 ! determination of adult lifespan GO:0008340 17 6 0,000 2,53E-03 0,01447252 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 2,53E-03 0,01443871 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 2,53E-03 0,01440505 ! neural plate development GO:0001840 9 6 0,000 2,53E-03 0,01437155 ! catecholamine transport GO:0051937 9 6 0,000 2,53E-03 0,0143382 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 2,53E-03 0,01430501 ! sensory cilium assembly GO:0035058 10 6 0,000 2,53E-03 0,01427198 ! organ or tissue specific immune response GO:0002251 8 6 0,000 2,53E-03 0,01423909 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 2,53E-03 0,01420636 ! maternal placenta development GO:0001893 12 6 0,000 2,53E-03 0,01417377 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 2,53E-03 0,01414134 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 2,53E-03 0,01410905 ! negative regulation of B cell activation GO:0050869 14 6 0,000 2,53E-03 0,01407692 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 2,53E-03 0,01404492 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 2,53E-03 0,01401307 ! positive regulation of coagulation GO:0050820 13 6 0,000 2,53E-03 0,01398137 ! cellular anion homeostasis GO:0030002 11 6 0,000 2,53E-03 0,01394981 GO:0055081|anion homeostasis, ! tRNA transcription GO:0009304 17 7 0,000 2,951E-03 0,01623493 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 2,951E-03 0,01619844 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 2,951E-03 0,01616212 ! behavioral response to cocaine GO:0048148 14 7 0,000 2,951E-03 0,01612597 ! regulation of helicase activity GO:0051095 16 7 0,000 2,951E-03 0,01608997 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 2,951E-03 0,01605414 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 2,951E-03 0,01601846 ! sleep GO:0030431 16 7 0,000 2,951E-03 0,01598294 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 2,951E-03 0,01594758 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 2,951E-03 0,01591238 ! prostate gland development GO:0030850 14 7 0,000 2,951E-03 0,01587733 ! nucleotide-sugar transport GO:0015780 11 7 0,000 2,951E-03 0,01584243 ! synaptonemal complex assembly GO:0007130 10 7 0,000 2,951E-03 0,01580769 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 2,951E-03 0,0157731 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 2,951E-03 0,01573866 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 2,951E-03 0,01570437 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 2,951E-03 0,01567023 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 2,951E-03 0,01563624 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! SMAD protein complex assembly GO:0007183 13 7 0,000 2,951E-03 0,0156024 ! glycolipid transport GO:0046836 11 7 0,000 2,951E-03 0,0155687 ! protein amino acid sulfation GO:0006477 10 7 0,000 2,951E-03 0,01553514 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 2,951E-03 0,01550174 ! neuron adhesion GO:0007158 14 7 0,000 2,951E-03 0,01546847 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 2,951E-03 0,01543535 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 2,951E-03 0,01540237 ! establishment of tissue polarity GO:0007164 8 7 0,000 2,951E-03 0,01536952 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 2,951E-03 0,01533682 ! mRNA stabilization GO:0048255 18 7 0,000 2,951E-03 0,01530426 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 2,951E-03 0,01527184 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 2,951E-03 0,01523955 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 2,951E-03 0,0152074 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 2,951E-03 0,01517538 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 2,951E-03 0,0151435 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 2,951E-03 0,01511176 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 2,951E-03 0,01508014 ! lipoprotein transport GO:0042953 14 7 0,000 2,951E-03 0,01504866 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 2,951E-03 0,01501731 ! rhythmic behavior GO:0007622 17 7 0,000 2,951E-03 0,01498609 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 2,951E-03 0,01495499 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 2,951E-03 0,01492403 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 2,951E-03 0,0148932 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 2,951E-03 0,01486249 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 2,951E-03 0,01483191 ! regulation of odontogenesis GO:0042481 14 7 0,000 2,951E-03 0,01480145 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 2,951E-03 0,01477112 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 2,951E-03 0,01474091 ! mechanosensory behavior GO:0007638 16 7 0,000 2,951E-03 0,01471083 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 2,951E-03 0,01468087 ! positive regulation of isotype switching GO:0045830 17 7 0,000 2,951E-03 0,01465103 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 2,951E-03 0,01462131 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 2,951E-03 0,01459171 ! protein-cofactor linkage GO:0018065 13 7 0,000 2,951E-03 0,01456224 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 2,951E-03 0,01453288 ! spinal cord patterning GO:0021511 14 7 0,000 2,951E-03 0,01450364 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 2,951E-03 0,01447451 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 2,951E-03 0,01444551 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 2,951E-03 0,01441661 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 2,951E-03 0,01438784 ! adrenal gland development GO:0030325 17 7 0,000 2,951E-03 0,01435918 ! cysteine metabolic process GO:0006534 13 7 0,000 2,951E-03 0,01433063 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 2,951E-03 0,0143022 ! ovulation GO:0030728 10 7 0,000 2,951E-03 0,01427388 ! adenohypophysis development GO:0021984 11 7 0,000 2,951E-03 0,01424567 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 2,951E-03 0,01421757 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 2,951E-03 0,01418958 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 2,951E-03 0,0141617 ! microtubule nucleation GO:0007020 21 7 0,000 2,951E-03 0,01413394 ! proline biosynthetic process GO:0006561 10 7 0,000 2,951E-03 0,01410628 ! tryptophan metabolic process GO:0006568 11 7 0,000 2,951E-03 0,01407872 ! thyroid hormone generation GO:0006590 13 7 0,000 2,951E-03 0,01405128 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 2,951E-03 0,01402394 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 2,951E-03 0,01399671 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 2,951E-03 0,01396959 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 2,951E-03 0,01394257 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 2,951E-03 0,01391565 ! galactose metabolic process GO:0006012 13 7 0,000 2,951E-03 0,01388884 ! vesicle fusion GO:0006906 20 7 0,000 2,951E-03 0,01386213 ! response to dietary excess GO:0002021 8 7 0,000 2,951E-03 0,01383552 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 2,951E-03 0,01380902 ! intracellular pH reduction GO:0051452 13 7 0,000 2,951E-03 0,01378261 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 2,951E-03 0,01375631 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 2,951E-03 0,01373011 ! organ growth GO:0035265 15 7 0,000 2,951E-03 0,01370401 ! nucleoside transport GO:0015858 11 7 0,000 2,951E-03 0,013678 ! nucleoside salvage GO:0043174 11 7 0,000 2,951E-03 0,0136521 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 2,951E-03 0,01362629 ! male sex determination GO:0030238 15 7 0,000 2,951E-03 0,01360058 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 2,951E-03 0,01357497 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 2,951E-03 0,01354945 ! parturition GO:0007567 16 7 0,000 2,951E-03 0,01352403 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 2,951E-03 0,0134987 ! rRNA modification GO:0000154 14 7 0,000 2,951E-03 0,01347347 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 2,951E-03 0,01344833 ! spindle checkpoint GO:0031577 16 7 0,000 2,951E-03 0,01342329 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 2,951E-03 0,01339834 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 2,951E-03 0,01337348 ! monocyte differentiation GO:0030224 16 7 0,000 2,951E-03 0,01334872 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 2,951E-03 0,01332404 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 2,951E-03 0,01329946 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 2,951E-03 0,01327497 ! hyaluronan metabolic process GO:0030212 9 7 0,000 2,951E-03 0,01325056 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 2,951E-03 0,01322625 ! anterograde axon cargo transport GO:0008089 18 7 0,000 2,951E-03 0,01320203 ! fibrinolysis GO:0042730 11 7 0,000 2,951E-03 0,01317789 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 2,951E-03 0,01315385 ! skeletal muscle contraction GO:0003009 8 7 0,000 2,951E-03 0,01312989 ! eating behavior GO:0042755 8 7 0,000 2,951E-03 0,01310601 ! B cell lineage commitment GO:0002326 21 7 0,000 2,951E-03 0,01308223 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 2,951E-03 0,01305853 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 2,951E-03 0,01303491 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 2,951E-03 0,01301138 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 2,951E-03 0,01298794 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 2,951E-03 0,01296458 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 2,951E-03 0,01294131 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 2,951E-03 0,01291811 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 2,951E-03 0,012895 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 2,951E-03 0,01287198 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 2,951E-03 0,01284903 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 2,951E-03 0,01282617 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 2,951E-03 0,01280339 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 2,951E-03 0,01278069 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 2,951E-03 0,01275807 ! histone ubiquitination GO:0016574 9 7 0,000 2,951E-03 0,01273552 ! regulation of meiosis GO:0040020 12 7 0,000 2,951E-03 0,01271306 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 2,951E-03 0,01269068 ! T cell lineage commitment GO:0002360 16 7 0,000 2,951E-03 0,01266838 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 2,951E-03 0,01264615 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 2,951E-03 0,01262401 ! membrane to membrane docking GO:0022614 14 7 0,000 2,951E-03 0,01260194 ! transcription termination GO:0006353 14 7 0,000 2,951E-03 0,01257994 ! coenzyme A metabolic process GO:0015936 12 7 0,000 2,951E-03 0,01255803 ! anaphase GO:0051322 18 7 0,000 2,951E-03 0,01253619 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 2,951E-03 0,01251442 ! axonal fasciculation GO:0007413 19 7 0,000 2,951E-03 0,01249273 ! negative regulation of nuclear division GO:0051784 15 7 0,000 2,951E-03 0,01247112 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 2,951E-03 0,01244958 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 2,951E-03 0,01242812 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 2,951E-03 0,01240672 ! diuresis GO:0030146 12 7 0,000 2,951E-03 0,01238541 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 2,951E-03 0,01236416 ! thiamin metabolic process GO:0006772 7 7 0,000 2,951E-03 0,01234299 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 2,951E-03 0,01232189 ! antibiotic transport GO:0042891 9 7 0,000 2,951E-03 0,01230087 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 2,951E-03 0,01227991 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 2,951E-03 0,01225903 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 2,951E-03 0,01223821 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 2,951E-03 0,01221747 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 2,951E-03 0,0121968 ! melanin biosynthetic process GO:0042438 10 7 0,000 2,951E-03 0,01217619 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 2,951E-03 0,01215566 ! dopamine biosynthetic process GO:0042416 18 7 0,000 2,951E-03 0,0121352 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 2,951E-03 0,0121148 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 2,951E-03 0,01209448 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 2,951E-03 0,01207422 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 2,951E-03 0,01205403 ! endosome to lysosome transport GO:0008333 12 7 0,000 2,951E-03 0,0120339 ! protein modification by small protein removal GO:0070646 19 7 0,000 2,951E-03 0,01201385 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 2,951E-03 0,01199386 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 2,951E-03 0,01197393 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 2,951E-03 0,01195407 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 2,951E-03 0,01193428 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 2,951E-03 0,01191456 ! muscle adaptation GO:0043500 13 7 0,000 2,951E-03 0,0118949 ! embryonic heart tube development GO:0035050 14 7 0,000 2,951E-03 0,0118753 ! retina homeostasis GO:0001895 12 7 0,000 2,951E-03 0,01185577 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 2,951E-03 0,0118363 ! protein amino acid prenylation GO:0018346 19 7 0,000 2,951E-03 0,0118169 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 2,951E-03 0,01179756 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 2,951E-03 0,01177828 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 3,371E-03 0,01343629 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 3,371E-03 0,0134144 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 3,371E-03 0,01339259 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 3,371E-03 0,01337085 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 3,371E-03 0,01334918 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 3,371E-03 0,01332758 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 3,371E-03 0,01330605 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 3,371E-03 0,01328459 ! male meiosis GO:0007140 9 8 0,000 3,371E-03 0,01326319 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 3,371E-03 0,01324187 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 3,371E-03 0,01322062 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 3,371E-03 0,01319943 ! meiotic prophase I GO:0007128 14 8 0,000 3,371E-03 0,01317831 ! response to zinc ion GO:0010043 12 8 0,000 3,371E-03 0,01315726 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 3,371E-03 0,01313627 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 3,371E-03 0,01311536 ! oligopeptide transport GO:0006857 16 8 0,000 3,371E-03 0,0130945 ! actin-myosin filament sliding GO:0033275 13 8 0,000 3,371E-03 0,01307372 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 3,371E-03 0,013053 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 3,371E-03 0,01303235 ! signal peptide processing GO:0006465 12 8 0,000 3,371E-03 0,01301176 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 3,371E-03 0,01299124 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 3,371E-03 0,01297078 ! macrophage chemotaxis GO:0048246 12 8 0,000 3,371E-03 0,01295038 ! succinate metabolic process GO:0006105 17 8 0,000 3,371E-03 0,01293005 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 3,371E-03 0,01290979 ! membrane hyperpolarization GO:0060081 11 8 0,000 3,371E-03 0,01288958 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 3,371E-03 0,01286944 ! estrogen metabolic process GO:0008210 17 8 0,000 3,371E-03 0,01284937 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 3,371E-03 0,01282935 ! T-helper 1 type immune response GO:0042088 12 8 0,000 3,371E-03 0,0128094 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 3,371E-03 0,01278951 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 3,371E-03 0,01276968 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 3,371E-03 0,01274991 ! reflex GO:0060004 17 8 0,000 3,371E-03 0,01273021 ! endothelial cell differentiation GO:0045446 17 8 0,000 3,371E-03 0,01271056 ! glycerolipid catabolic process GO:0046503 14 8 0,000 3,371E-03 0,01269098 ! hemoglobin metabolic process GO:0020027 14 8 0,000 3,371E-03 0,01267145 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 3,371E-03 0,01265199 ! pigment granule organization GO:0048753 17 8 0,000 3,371E-03 0,01263258 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 3,371E-03 0,01261324 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 3,371E-03 0,01259395 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 3,371E-03 0,01257472 ! astrocyte differentiation GO:0048708 19 8 0,000 3,371E-03 0,01255555 ! histidine catabolic process GO:0006548 10 8 0,000 3,371E-03 0,01253644 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 3,371E-03 0,01251739 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 3,371E-03 0,0124984 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 3,371E-03 0,01247946 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 3,371E-03 0,01246058 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 3,371E-03 0,01244176 ! regulation of pigmentation during development GO:0048070 25 8 0,000 3,371E-03 0,01242299 ! melanin metabolic process GO:0006582 17 8 0,000 3,371E-03 0,01240428 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 3,371E-03 0,01238563 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 3,371E-03 0,01236703 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 3,371E-03 0,01234849 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 3,371E-03 0,01233 ! macrophage activation GO:0042116 13 8 0,000 3,371E-03 0,01231157 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 3,371E-03 0,0122932 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 3,371E-03 0,01227488 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 3,371E-03 0,01225661 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 3,371E-03 0,0122384 ! purine salvage GO:0043101 12 8 0,000 3,371E-03 0,01222024 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 3,371E-03 0,01220214 ! regulation of vascular permeability GO:0043114 12 8 0,000 3,371E-03 0,01218409 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 3,371E-03 0,01216609 ! osteoblast development GO:0002076 17 8 0,000 3,371E-03 0,01214815 ! positive regulation of vasodilation GO:0045909 14 8 0,000 3,371E-03 0,01213026 ! negative regulation of translational initiation GO:0045947 12 8 0,000 3,371E-03 0,01211242 ! Schwann cell differentiation GO:0014037 21 8 0,000 3,371E-03 0,01209463 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 3,371E-03 0,0120769 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 3,371E-03 0,01205921 ! response to UV-B GO:0010224 17 8 0,000 3,371E-03 0,01204158 ! protein targeting to vacuole GO:0006623 14 8 0,000 3,371E-03 0,012024 ! protein retention in ER lumen GO:0006621 14 8 0,000 3,371E-03 0,01200648 ! intermediate filament organization GO:0045109 12 8 0,000 3,371E-03 0,011989 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 3,371E-03 0,01197157 ! cellular extravasation GO:0045123 13 8 0,000 3,371E-03 0,0119542 ! cardiac muscle cell development GO:0055013 14 8 0,000 3,371E-03 0,01193687 ! response to antibiotic GO:0046677 11 8 0,000 3,371E-03 0,0119196 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 3,371E-03 0,01190237 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 3,371E-03 0,0118852 ! DNA topological change GO:0006265 12 8 0,000 3,371E-03 0,01186807 ! response to tropane GO:0014073 15 8 0,000 3,371E-03 0,011851 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 3,371E-03 0,01183397 ! melanosome transport GO:0032402 13 8 0,000 3,371E-03 0,01181699 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 0,000 3,371E-03 0,01180006 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 3,371E-03 0,01178318 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 3,371E-03 0,01176635 ! mast cell activation GO:0045576 14 8 0,000 3,371E-03 0,01174956 ! multicellular organismal aging GO:0010259 20 8 0,000 3,371E-03 0,01173283 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 3,371E-03 0,01171614 ! gas homeostasis GO:0033483 14 8 0,000 3,371E-03 0,01169949 ! dendrite morphogenesis GO:0048813 14 8 0,000 3,371E-03 0,0116829 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 3,371E-03 0,01166635 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 3,371E-03 0,01164985 ! nucleosome disassembly GO:0006337 14 8 0,000 3,371E-03 0,01163339 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 3,371E-03 0,01161699 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 3,371E-03 0,01160062 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 3,371E-03 0,01158431 ! establishment of chromosome localization GO:0051303 14 8 0,000 3,371E-03 0,01156804 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 3,371E-03 0,01155181 ! intracellular lipid transport GO:0032365 16 8 0,000 3,371E-03 0,01153563 ! response to tumor cell GO:0002347 16 8 0,000 3,371E-03 0,0115195 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 3,371E-03 0,01150341 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 3,371E-03 0,01148737 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 3,371E-03 0,01147137 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 3,371E-03 0,01145541 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 3,371E-03 0,0114395 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 3,371E-03 0,01142364 ! hormone catabolic process GO:0042447 17 8 0,000 3,371E-03 0,01140782 ! glycolipid catabolic process GO:0019377 16 8 0,000 3,371E-03 0,01139204 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 3,371E-03 0,0113763 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 3,371E-03 0,01136061 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 3,371E-03 0,01134496 ! positive regulation of glucose import GO:0046326 8 8 0,000 3,371E-03 0,01132936 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 3,371E-03 0,0113138 ! adult feeding behavior GO:0008343 10 8 0,000 3,371E-03 0,01129828 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 3,371E-03 0,0112828 ! ATP catabolic process GO:0006200 11 8 0,000 3,371E-03 0,01126736 ! blastocyst growth GO:0001832 19 8 0,000 3,371E-03 0,01125197 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 3,371E-03 0,01123662 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 3,371E-03 0,01122131 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 3,371E-03 0,01120605 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 3,371E-03 0,01119082 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 3,371E-03 0,01117564 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 3,371E-03 0,01116049 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 3,371E-03 0,01114539 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 3,371E-03 0,01113033 ! amino sugar catabolic process GO:0046348 11 8 0,000 3,371E-03 0,01111531 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 3,371E-03 0,01110033 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 3,371E-03 0,01108539 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 3,371E-03 0,01107049 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 3,371E-03 0,01105563 ! behavioral response to nicotine GO:0035095 12 8 0,000 3,371E-03 0,01104081 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 3,371E-03 0,01102603 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 3,371E-03 0,01101129 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 3,371E-03 0,01099659 ! NAD biosynthetic process GO:0009435 17 8 0,000 3,371E-03 0,01098192 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 3,371E-03 0,0109673 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 3,371E-03 0,01095272 ! axon extension GO:0048675 16 9 0,000 3,792E-03 0,01230302 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 3,792E-03 0,0122867 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 3,792E-03 0,01227043 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 3,792E-03 0,0122542 ! pentose-phosphate shunt GO:0006098 16 9 0,000 3,792E-03 0,01223801 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 3,792E-03 0,01222187 ! cell proliferation in forebrain GO:0021846 18 9 0,000 3,792E-03 0,01220576 ! neutral lipid catabolic process GO:0046461 14 9 0,000 3,792E-03 0,0121897 ! reproductive behavior GO:0019098 22 9 0,000 3,792E-03 0,01217369 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 3,792E-03 0,01215771 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 3,792E-03 0,01214178 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 3,792E-03 0,01212588 ! UTP metabolic process GO:0046051 10 9 0,000 3,792E-03 0,01211003 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 3,792E-03 0,01209422 ! induction of positive chemotaxis GO:0050930 17 9 0,000 3,792E-03 0,01207845 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 3,792E-03 0,01206273 ! artery development GO:0060840 25 9 0,000 3,792E-03 0,01204704 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 3,792E-03 0,0120314 ! regulation of glycolysis GO:0006110 20 9 0,000 3,792E-03 0,01201579 ! cerebral cortex cell migration GO:0021795 18 9 0,000 3,792E-03 0,01200023 ! equilibrioception GO:0050957 20 9 0,000 3,792E-03 0,0119847 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 3,792E-03 0,01196922 ! chemosensory behavior GO:0007635 21 9 0,000 3,792E-03 0,01195377 ! microtubule bundle formation GO:0001578 22 9 0,000 3,792E-03 0,01193837 ! middle ear morphogenesis GO:0042474 14 9 0,000 3,792E-03 0,011923 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 3,792E-03 0,01190768 ! leukocyte degranulation GO:0043299 16 9 0,000 3,792E-03 0,01189239 ! ganglioside metabolic process GO:0001573 22 9 0,000 3,792E-03 0,01187715 ! negative regulation of endocytosis GO:0045806 12 9 0,000 3,792E-03 0,01186194 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 3,792E-03 0,01184677 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 3,792E-03 0,01183164 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 3,792E-03 0,01181655 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 3,792E-03 0,0118015 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 3,792E-03 0,01178648 ! protein targeting to ER GO:0045047 25 9 0,000 3,792E-03 0,01177151 ! ceramide biosynthetic process GO:0046513 20 9 0,000 3,792E-03 0,01175657 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 3,792E-03 0,01174167 ! T cell selection GO:0045058 27 9 0,000 3,792E-03 0,0117268 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 0,000 3,792E-03 0,01171198 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 3,792E-03 0,01169719 ! glycine catabolic process GO:0006546 15 9 0,000 3,792E-03 0,01168244 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 3,792E-03 0,01166773 ! endosome organization GO:0007032 20 9 0,000 3,792E-03 0,01165305 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 3,792E-03 0,01163841 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 3,792E-03 0,01162381 ! regulation of type I interferon production GO:0032479 12 9 0,000 3,792E-03 0,01160924 ! mannose metabolic process GO:0006013 13 9 0,000 3,792E-03 0,01159471 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 3,792E-03 0,01158022 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 3,792E-03 0,01156576 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 3,792E-03 0,01155134 ! Rac protein signal transduction GO:0016601 20 9 0,000 3,792E-03 0,01153695 ! receptor clustering GO:0043113 20 9 0,000 3,792E-03 0,01152261 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 3,792E-03 0,01150829 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 3,792E-03 0,01149401 ! retinol metabolic process GO:0042572 20 9 0,000 3,792E-03 0,01147977 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 3,792E-03 0,01146556 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 3,792E-03 0,01145139 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 3,792E-03 0,01143725 ! macrophage differentiation GO:0030225 15 9 0,000 3,792E-03 0,01142315 ! oligodendrocyte development GO:0014003 11 9 0,000 3,792E-03 0,01140908 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 3,792E-03 0,01139505 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 3,792E-03 0,01138105 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 3,792E-03 0,01136709 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 3,792E-03 0,01135315 ! response to amine stimulus GO:0014075 13 9 0,000 3,792E-03 0,01133926 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 3,792E-03 0,0113254 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 3,792E-03 0,01131157 ! erythrocyte development GO:0048821 17 9 0,000 3,792E-03 0,01129777 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 3,792E-03 0,01128401 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 3,792E-03 0,01127029 ! renal water homeostasis GO:0003091 15 9 0,000 3,792E-03 0,01125659 ! postreplication repair GO:0006301 25 9 0,000 3,792E-03 0,01124293 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 3,792E-03 0,0112293 ! icosanoid secretion GO:0032309 15 9 0,000 3,792E-03 0,01121571 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 3,792E-03 0,01120215 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 3,792E-03 0,01118862 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 3,792E-03 0,01117512 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 3,792E-03 0,01116166 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 3,792E-03 0,01114822 ! sterol catabolic process GO:0016127 14 9 0,000 3,792E-03 0,01113483 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 3,792E-03 0,01112146 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 3,792E-03 0,01110812 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 3,792E-03 0,01109482 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 3,792E-03 0,01108155 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 3,792E-03 0,01106831 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 3,792E-03 0,0110551 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 3,792E-03 0,01104192 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 3,792E-03 0,01102878 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 3,792E-03 0,01101567 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 3,792E-03 0,01100258 ! regulation of synaptogenesis GO:0051963 15 9 0,000 3,792E-03 0,01098953 ! purine base metabolic process GO:0006144 25 9 0,000 3,792E-03 0,01097651 ! pigment granule transport GO:0051904 17 9 0,000 3,792E-03 0,01096352 ! regulation of telomere maintenance GO:0032204 17 9 0,000 3,792E-03 0,01095056 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 3,792E-03 0,01093763 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 3,792E-03 0,01092473 ! regulation of muscle adaptation GO:0043502 14 9 0,000 3,792E-03 0,01091187 ! regulation of amino acid transport GO:0051955 12 9 0,000 3,792E-03 0,01089903 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 3,792E-03 0,01088622 ! mitochondrion localization GO:0051646 18 9 0,000 3,792E-03 0,01087344 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 4,213E-03 0,01206507 ! regulation of developmental growth GO:0048638 16 10 0,000 4,213E-03 0,01205094 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 4,213E-03 0,01203684 ! autophagic vacuole formation GO:0000045 17 10 0,000 4,213E-03 0,01202278 ! negative regulation of blood pressure GO:0045776 26 10 0,000 4,213E-03 0,01200875 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 4,213E-03 0,01199476 ! associative learning GO:0008306 21 10 0,000 4,213E-03 0,01198079 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 4,213E-03 0,01196686 ! regulation of phosphatase activity GO:0010921 28 10 0,000 4,213E-03 0,01195296 ! phosphate transport GO:0006817 24 10 0,000 4,213E-03 0,0119391 ! cell volume homeostasis GO:0006884 17 10 0,000 4,213E-03 0,01192526 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 4,213E-03 0,01191146 ! CTP metabolic process GO:0046036 11 10 0,000 4,213E-03 0,01189769 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 4,213E-03 0,01188395 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 4,213E-03 0,01187024 ! GTP metabolic process GO:0046039 11 10 0,000 4,213E-03 0,01185657 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 4,213E-03 0,01184292 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 4,213E-03 0,01182931 ! social behavior GO:0035176 29 10 0,000 4,213E-03 0,01181573 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 4,213E-03 0,01180218 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 4,213E-03 0,01178866 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 4,213E-03 0,01177517 ! androgen metabolic process GO:0008209 17 10 0,000 4,213E-03 0,01176172 ! phospholipid efflux GO:0033700 19 10 0,000 4,213E-03 0,01174829 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 4,213E-03 0,01173489 ! bile acid and bile salt transport GO:0015721 15 10 0,000 4,213E-03 0,01172153 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 4,213E-03 0,01170819 ! positive regulation of heart contraction GO:0045823 17 10 0,000 4,213E-03 0,01169489 ! lung alveolus development GO:0048286 26 10 0,000 4,213E-03 0,01168161 ! pathogenesis GO:0009405 17 10 0,000 4,213E-03 0,01166837 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 4,213E-03 0,01165515 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 4,213E-03 0,01164197 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 4,213E-03 0,01162881 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 4,213E-03 0,01161569 ! endoderm development GO:0007492 18 10 0,000 4,213E-03 0,01160259 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 4,213E-03 0,01158953 ! arginine catabolic process GO:0006527 17 10 0,000 4,213E-03 0,01157649 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 4,213E-03 0,01156348 ! proline metabolic process GO:0006560 13 10 0,000 4,213E-03 0,01155051 ! glucan biosynthetic process GO:0009250 14 10 0,000 4,213E-03 0,01153756 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 4,213E-03 0,01152464 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 4,213E-03 0,01151175 ! V(D)J recombination GO:0033151 34 10 0,000 4,213E-03 0,01149888 ! reverse cholesterol transport GO:0043691 19 10 0,000 4,213E-03 0,01148605 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 4,213E-03 0,01147324 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 4,213E-03 0,01146047 ! B cell proliferation GO:0042100 19 10 0,000 4,213E-03 0,01144772 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 4,213E-03 0,011435 ! regulation of sodium ion transport GO:0002028 26 10 0,000 4,213E-03 0,01142231 ! multicellular organism growth GO:0035264 19 10 0,000 4,213E-03 0,01140965 ! phagocytosis, engulfment GO:0006911 33 10 0,000 4,213E-03 0,01139701 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 4,213E-03 0,0113844 ! ruffle organization GO:0031529 17 10 0,000 4,213E-03 0,01137182 ! epithelial cell development GO:0002064 21 10 0,000 4,213E-03 0,01135927 ! lens development in camera-type eye GO:0002088 17 10 0,000 4,213E-03 0,01134675 ! retinoic acid metabolic process GO:0042573 14 10 0,000 4,213E-03 0,01133425 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 4,213E-03 0,01132178 ! positive regulation of translational initiation GO:0045948 12 10 0,000 4,213E-03 0,01130934 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 4,213E-03 0,01129693 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 4,213E-03 0,01128454 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 4,213E-03 0,01127218 ! motor axon guidance GO:0008045 22 10 0,000 4,213E-03 0,01125985 ! copper ion homeostasis GO:0055070 13 10 0,000 4,213E-03 0,01124754 ! regulation of bone resorption GO:0045124 25 10 0,000 4,213E-03 0,01123526 ! protein heterooligomerization GO:0051291 17 10 0,000 4,213E-03 0,01122301 ! regulation of gliogenesis GO:0014013 23 10 0,000 4,213E-03 0,01121079 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 4,213E-03 0,01119859 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 4,213E-03 0,01118641 ! segment specification GO:0007379 15 10 0,000 4,213E-03 0,01117427 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 4,213E-03 0,01116215 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 4,213E-03 0,01115005 ! blastoderm segmentation GO:0007350 19 10 0,000 4,213E-03 0,01113799 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 4,213E-03 0,01112595 ! response to dsRNA GO:0043331 23 10 0,000 4,213E-03 0,01111393 ! DNA ligation GO:0006266 18 10 0,000 4,213E-03 0,01110194 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 4,213E-03 0,01108998 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 4,213E-03 0,01107804 ! melanosome localization GO:0032400 16 10 0,000 4,213E-03 0,01106613 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 4,213E-03 0,01105424 ! regulation of B cell differentiation GO:0045577 24 10 0,000 4,213E-03 0,01104238 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 4,213E-03 0,01103055 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 4,213E-03 0,01101874 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 4,213E-03 0,01100695 ! induction of an organ GO:0001759 17 10 0,000 4,213E-03 0,01099519 ! leukocyte activation during immune response GO:0002366 15 10 0,000 4,213E-03 0,01098346 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 4,213E-03 0,01097175 ! protein sumoylation GO:0016925 17 10 0,000 4,213E-03 0,01096006 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 4,213E-03 0,0109484 ! hindbrain morphogenesis GO:0021575 19 10 0,000 4,213E-03 0,01093677 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 4,213E-03 0,01092516 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 4,213E-03 0,01091357 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 4,213E-03 0,01090201 ! salivary gland development GO:0007431 28 10 0,000 4,213E-03 0,01089048 ! ubiquinone metabolic process GO:0006743 17 10 0,000 4,213E-03 0,01087896 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 4,213E-03 0,01086748 ! midbrain development GO:0030901 14 10 0,000 4,213E-03 0,01085601 ! musculoskeletal movement GO:0050881 16 10 0,000 4,213E-03 0,01084457 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 4,213E-03 0,01083316 ! methionine biosynthetic process GO:0009086 21 10 0,000 4,213E-03 0,01082177 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 4,213E-03 0,0108104 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 4,213E-03 0,01079906 ! quaternary ammonium group transport GO:0015697 22 10 0,000 4,213E-03 0,01078774 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 4,213E-03 0,01077644 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 4,213E-03 0,01076517 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 4,213E-03 0,01075392 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 4,213E-03 0,01074269 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 4,213E-03 0,01073149 ! establishment of pigment granule localization GO:0051905 18 10 0,000 4,213E-03 0,01072031 ! blastocyst formation GO:0001825 18 10 0,000 4,213E-03 0,01070916 ! regulation of fibrinolysis GO:0051917 20 10 0,000 4,213E-03 0,01069803 ! cerebellar cortex development GO:0021695 16 10 0,000 4,213E-03 0,01068692 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 4,213E-03 0,01067583 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 4,213E-03 0,01066477 ! response to nicotine GO:0035094 20 10 0,000 4,213E-03 0,01065373 ! negative regulation of immune effector process GO:0002698 23 10 0,000 4,213E-03 0,01064271 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 4,213E-03 0,01063172 ! negative regulation of muscle development GO:0048635 27 11 0,000 4,633E-03 0,01168052 ! respiratory burst GO:0045730 17 11 0,000 4,633E-03 0,01166848 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 4,633E-03 0,01165646 ! neuron fate specification GO:0048665 18 11 0,000 4,633E-03 0,01164447 ! telencephalon cell migration GO:0022029 23 11 0,000 4,633E-03 0,0116325 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 4,633E-03 0,01162056 ! thyroid gland development GO:0030878 26 11 0,000 4,633E-03 0,01160864 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 4,633E-03 0,01159674 ! synapsis GO:0007129 14 11 0,000 4,633E-03 0,01158487 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 4,633E-03 0,01157303 ! Golgi vesicle budding GO:0048194 26 11 0,000 4,633E-03 0,01156121 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 4,633E-03 0,01154941 ! response to pain GO:0048265 27 11 0,000 4,633E-03 0,01153764 ! detection of mechanical stimulus GO:0050982 22 11 0,000 4,633E-03 0,01152589 ! keratinocyte proliferation GO:0043616 19 11 0,000 4,633E-03 0,01151416 ! blood vessel remodeling GO:0001974 30 11 0,000 4,633E-03 0,01150246 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 4,633E-03 0,01149078 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 4,633E-03 0,01147913 ! bone resorption GO:0045453 16 11 0,000 4,633E-03 0,0114675 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 4,633E-03 0,01145589 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 4,633E-03 0,01144431 ! negative regulation of proteolysis GO:0045861 25 11 0,000 4,633E-03 0,01143275 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 4,633E-03 0,01142121 ! melanocyte differentiation GO:0030318 20 11 0,000 4,633E-03 0,0114097 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 4,633E-03 0,01139821 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 4,633E-03 0,01138674 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 4,633E-03 0,0113753 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 4,633E-03 0,01136388 ! regulation of intracellular pH GO:0051453 21 11 0,000 4,633E-03 0,01135248 ! substrate-bound cell migration GO:0006929 14 11 0,000 4,633E-03 0,0113411 ! UV protection GO:0009650 20 11 0,000 4,633E-03 0,01132975 ! adult heart development GO:0007512 16 11 0,000 4,633E-03 0,01131842 ! chondrocyte differentiation GO:0002062 27 11 0,000 4,633E-03 0,01130712 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 4,633E-03 0,01129583 ! macroautophagy GO:0016236 19 11 0,000 4,633E-03 0,01128457 ! temperature homeostasis GO:0001659 18 11 0,000 4,633E-03 0,01127333 ! behavioral fear response GO:0001662 27 11 0,000 4,633E-03 0,01126211 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 4,633E-03 0,01125092 ! negative regulation of ossification GO:0030279 27 11 0,000 4,633E-03 0,01123974 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 4,633E-03 0,01122859 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 4,633E-03 0,01121746 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 4,633E-03 0,01120636 ! alpha-beta T cell activation GO:0046631 26 11 0,000 4,633E-03 0,01119527 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 4,633E-03 0,01118421 ! regulation of organ growth GO:0046620 14 11 0,000 4,633E-03 0,01117317 ! pigment granule localization GO:0051875 20 11 0,000 4,633E-03 0,01116215 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 4,633E-03 0,01115115 ! vasoconstriction GO:0042310 20 11 0,000 4,633E-03 0,01114018 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 4,633E-03 0,01112923 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 4,633E-03 0,01111829 ! embryonic axis specification GO:0000578 19 11 0,000 4,633E-03 0,01110738 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 4,633E-03 0,01109649 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 4,633E-03 0,01108562 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 4,633E-03 0,01107478 ! nitric oxide metabolic process GO:0046209 17 11 0,000 4,633E-03 0,01106395 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 4,633E-03 0,01105315 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 4,633E-03 0,01104236 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 4,633E-03 0,0110316 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 4,633E-03 0,01102086 ! prophase GO:0051324 17 11 0,000 4,633E-03 0,01101014 ! neuroblast proliferation GO:0007405 25 11 0,000 4,633E-03 0,01099944 ! nucleosome positioning GO:0016584 15 11 0,000 4,633E-03 0,01098876 ! regulation of isotype switching GO:0045191 24 11 0,000 4,633E-03 0,0109781 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 4,633E-03 0,01096746 ! negative regulation of neurological system process GO:0031645 21 11 0,000 4,633E-03 0,01095685 ! apical protein localization GO:0045176 18 11 0,000 4,633E-03 0,01094625 ! acid secretion GO:0046717 20 11 0,000 4,633E-03 0,01093567 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 4,633E-03 0,01092512 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 4,633E-03 0,01091458 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 4,633E-03 0,01090407 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 4,633E-03 0,01089357 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 4,633E-03 0,0108831 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 4,633E-03 0,01087264 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 4,633E-03 0,01086221 ! cholesterol efflux GO:0033344 21 11 0,000 4,633E-03 0,01085179 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 4,633E-03 0,0108414 ! oocyte development GO:0048599 20 11 0,000 4,633E-03 0,01083103 ! negative regulation of glucose import GO:0046325 18 11 0,000 4,633E-03 0,01082067 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 4,633E-03 0,01081034 ! embryonic gut development GO:0048566 19 11 0,000 4,633E-03 0,01080002 ! regulation of organic acid transport GO:0032890 19 11 0,000 4,633E-03 0,01078973 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 4,633E-03 0,01077945 ! activation of innate immune response GO:0002218 16 11 0,000 4,633E-03 0,01076919 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 4,633E-03 0,01075896 ! cardiac cell differentiation GO:0035051 36 11 0,000 4,633E-03 0,01074874 ! lysogeny GO:0030069 22 11 0,000 4,633E-03 0,01073854 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 4,633E-03 0,01072836 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 4,633E-03 0,0107182 ! sequestering of metal ion GO:0051238 15 11 0,000 4,633E-03 0,01070806 ! regulation of embryonic development GO:0045995 35 11 0,000 4,633E-03 0,01069794 ! nucleus localization GO:0051647 22 11 0,000 4,633E-03 0,01068784 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 5,053E-03 0,01164617 ! positive regulation of blood pressure GO:0045777 18 12 0,000 5,053E-03 0,01163519 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 5,053E-03 0,01162424 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 5,053E-03 0,0116133 ! virus-host interaction GO:0019048 30 12 0,000 5,053E-03 0,01160239 ! regulation of B cell proliferation GO:0030888 22 12 0,000 5,053E-03 0,01159149 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 5,053E-03 0,01158062 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 5,053E-03 0,01156976 ! protein complex disassembly GO:0043241 28 12 0,000 5,053E-03 0,01155893 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 5,053E-03 0,01154812 ! regulation of cell projection assembly GO:0060491 33 12 0,000 5,053E-03 0,01153733 ! hippocampus development GO:0021766 29 12 0,000 5,053E-03 0,01152655 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 5,053E-03 0,0115158 ! cytokine biosynthetic process GO:0042089 23 12 0,000 5,053E-03 0,01150507 ! T cell proliferation GO:0042098 32 12 0,000 5,053E-03 0,01149436 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 5,053E-03 0,01148366 ! regulation of exit from mitosis GO:0007096 19 12 0,000 5,053E-03 0,01147299 ! ventral spinal cord development GO:0021517 25 12 0,000 5,053E-03 0,01146234 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 5,053E-03 0,01145171 ! drug transport GO:0015893 16 12 0,000 5,053E-03 0,01144109 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 5,053E-03 0,0114305 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 5,053E-03 0,01141993 ! tyrosine metabolic process GO:0006570 19 12 0,000 5,053E-03 0,01140937 ! polyamine metabolic process GO:0006595 18 12 0,000 5,053E-03 0,01139884 ! focal adhesion formation GO:0048041 37 12 0,000 5,053E-03 0,01138832 ! mitotic spindle organization GO:0007052 23 12 0,000 5,053E-03 0,01137782 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 5,053E-03 0,01136735 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 5,053E-03 0,01135689 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 5,053E-03 0,01134645 ! lipid digestion GO:0044241 21 12 0,000 5,053E-03 0,01133603 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 5,053E-03 0,01132563 ! entry into host cell GO:0030260 34 12 0,000 5,053E-03 0,01131525 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 5,053E-03 0,01130489 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 5,053E-03 0,01129455 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 5,053E-03 0,01128422 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 5,053E-03 0,01127392 ! protein targeting to peroxisome GO:0006625 27 12 0,000 5,053E-03 0,01126363 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 5,053E-03 0,01125336 ! regulation of phagocytosis GO:0050764 17 12 0,000 5,053E-03 0,01124311 ! snRNA metabolic process GO:0016073 30 12 0,000 5,053E-03 0,01123288 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 5,053E-03 0,01122267 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 5,053E-03 0,01121248 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 5,053E-03 0,0112023 ! cranial nerve development GO:0021545 23 12 0,000 5,053E-03 0,01119215 ! fucose catabolic process GO:0019317 25 12 0,000 5,053E-03 0,01118201 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 5,053E-03 0,01117189 ! histone acetylation GO:0016573 27 12 0,000 5,053E-03 0,01116179 ! mRNA polyadenylation GO:0006378 24 12 0,000 5,053E-03 0,01115171 ! autonomic nervous system development GO:0048483 24 12 0,000 5,053E-03 0,01114164 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 5,053E-03 0,0111316 ! zymogen activation GO:0031638 18 12 0,000 5,053E-03 0,01112157 ! peptidyl-lysine modification GO:0018205 21 12 0,000 5,053E-03 0,01111156 ! T cell homeostasis GO:0043029 28 12 0,000 5,053E-03 0,01110156 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 5,053E-03 0,01109159 ! glutathione biosynthetic process GO:0006750 15 12 0,000 5,053E-03 0,01108163 ! regulation of leukocyte migration GO:0002685 29 12 0,000 5,053E-03 0,01107169 ! oocyte differentiation GO:0009994 21 12 0,000 5,053E-03 0,01106177 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 5,053E-03 0,01105187 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 5,053E-03 0,01104198 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 5,053E-03 0,01103212 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 5,053E-03 0,01102227 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 5,053E-03 0,01101243 ! defense response to fungus GO:0050832 15 12 0,000 5,053E-03 0,01100262 ! developmental induction GO:0031128 22 12 0,000 5,053E-03 0,01099282 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 5,053E-03 0,01098304 ! lamellipodium assembly GO:0030032 24 12 0,000 5,053E-03 0,01097328 ! response to cold GO:0009409 17 12 0,000 5,053E-03 0,01096353 ! establishment of cell polarity GO:0030010 21 12 0,000 5,053E-03 0,01095381 ! regulation of synapse organization GO:0050807 18 12 0,000 5,053E-03 0,01094409 ! localization within membrane GO:0051668 26 12 0,000 5,053E-03 0,0109344 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 5,473E-03 0,01183279 ! cGMP metabolic process GO:0046068 18 13 0,000 5,473E-03 0,01182233 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 5,473E-03 0,01181188 ! regulation of chemokine production GO:0032642 18 13 0,000 5,473E-03 0,01180146 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 5,473E-03 0,01179105 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 5,473E-03 0,01178066 ! peroxisomal transport GO:0043574 28 13 0,000 5,473E-03 0,01177029 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 5,473E-03 0,01175994 ! cartilage condensation GO:0001502 22 13 0,000 5,473E-03 0,01174961 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 5,473E-03 0,01173929 ! organelle fusion GO:0048284 36 13 0,000 5,473E-03 0,01172899 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 5,473E-03 0,01171871 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 5,473E-03 0,01170845 ! pseudouridine synthesis GO:0001522 19 13 0,000 5,473E-03 0,01169821 ! endocrine pancreas development GO:0031018 25 13 0,000 5,473E-03 0,01168798 ! positive regulation of cell growth GO:0030307 24 13 0,000 5,473E-03 0,01167777 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 5,473E-03 0,01166758 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 5,473E-03 0,01165741 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 5,473E-03 0,01164726 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 5,473E-03 0,01163712 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 5,473E-03 0,011627 ! methionine metabolic process GO:0006555 31 13 0,000 5,473E-03 0,0116169 ! plasma membrane organization GO:0007009 27 13 0,000 5,473E-03 0,01160682 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 5,473E-03 0,01159675 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 5,473E-03 0,0115867 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 5,473E-03 0,01157667 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 5,473E-03 0,01156665 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 5,473E-03 0,01155666 ! cytokine metabolic process GO:0042107 24 13 0,000 5,473E-03 0,01154668 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 5,473E-03 0,01153671 ! exocrine system development GO:0035272 34 13 0,000 5,473E-03 0,01152677 ! asymmetric protein localization GO:0008105 24 13 0,000 5,473E-03 0,01151684 ! membrane protein proteolysis GO:0033619 33 13 0,000 5,473E-03 0,01150693 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 5,473E-03 0,01149703 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 5,473E-03 0,01148716 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 5,473E-03 0,0114773 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 5,473E-03 0,01146745 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 5,473E-03 0,01145763 ! protein homotetramerization GO:0051289 24 13 0,000 5,473E-03 0,01144782 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 5,473E-03 0,01143803 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 5,473E-03 0,01142825 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 5,473E-03 0,01141849 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 5,473E-03 0,01140875 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 5,473E-03 0,01139902 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 5,473E-03 0,01138931 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 5,473E-03 0,01137962 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 5,473E-03 0,01136994 ! histone methylation GO:0016571 29 13 0,000 5,473E-03 0,01136028 ! chromatin silencing GO:0006342 29 13 0,000 5,473E-03 0,01135064 ! gland morphogenesis GO:0022612 31 13 0,000 5,473E-03 0,01134101 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 5,473E-03 0,0113314 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 5,473E-03 0,0113218 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 5,473E-03 0,01131223 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 5,473E-03 0,01130266 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 5,473E-03 0,01129312 ! spleen development GO:0048536 24 13 0,000 5,473E-03 0,01128359 ! regulation of mRNA stability GO:0043488 32 13 0,000 5,473E-03 0,01127407 ! digestive tract morphogenesis GO:0048546 31 13 0,000 5,473E-03 0,01126458 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 5,473E-03 0,01125509 ! anterior/posterior axis specification GO:0009948 22 13 0,000 5,473E-03 0,01124563 ! regulation of RNA splicing GO:0043484 22 13 0,000 5,473E-03 0,01123618 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 5,473E-03 0,01122674 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 5,473E-03 0,01121733 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 5,473E-03 0,01120792 ! mRNA 3'-end processing GO:0031124 25 13 0,000 5,473E-03 0,01119854 ! insulin secretion GO:0030073 24 13 0,000 5,473E-03 0,01118916 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 5,473E-03 0,01117981 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 5,473E-03 0,01117047 ! acrosome reaction GO:0007340 19 13 0,000 5,473E-03 0,01116114 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 5,473E-03 0,01115184 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 5,473E-03 0,01114254 ! rRNA transcription GO:0009303 28 14 0,000 5,893E-03 0,01198731 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 5,893E-03 0,01197734 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 5,893E-03 0,01196738 ! water transport GO:0006833 21 14 0,000 5,893E-03 0,01195744 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 5,893E-03 0,01194752 ! non-recombinational repair GO:0000726 29 14 0,000 5,893E-03 0,01193761 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 5,893E-03 0,01192772 ! retina development in camera-type eye GO:0060041 28 14 0,000 5,893E-03 0,01191785 ! hair follicle morphogenesis GO:0031069 27 14 0,000 5,893E-03 0,01190799 ! RNA polyadenylation GO:0043631 32 14 0,000 5,893E-03 0,01189815 ! lipid localization GO:0010876 32 14 0,000 5,893E-03 0,01188832 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 5,893E-03 0,01187851 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 5,893E-03 0,01186872 ! regulated secretory pathway GO:0045055 24 14 0,000 5,893E-03 0,01185895 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 5,893E-03 0,01184918 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 5,893E-03 0,01183944 ! arginine metabolic process GO:0006525 21 14 0,000 5,893E-03 0,01182971 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 5,893E-03 0,01182 ! cell-cell junction assembly GO:0007043 32 14 0,000 5,893E-03 0,0118103 ! regulation of heart rate GO:0002027 25 14 0,000 5,893E-03 0,01180062 ! fear response GO:0042596 34 14 0,000 5,893E-03 0,01179096 ! organic alcohol transport GO:0015850 29 14 0,000 5,893E-03 0,01178131 ! negative regulation of caspase activity GO:0043154 23 14 0,000 5,893E-03 0,01177168 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 5,893E-03 0,01176206 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 5,893E-03 0,01175246 ! neutral amino acid transport GO:0015804 28 14 0,000 5,893E-03 0,01174287 ! bone mineralization GO:0030282 18 14 0,000 5,893E-03 0,0117333 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 5,893E-03 0,01172375 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 5,893E-03 0,01171421 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 5,893E-03 0,01170468 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 5,893E-03 0,01169517 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 5,893E-03 0,01168568 ! regulation of cellular pH GO:0030641 27 14 0,000 5,893E-03 0,0116762 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 5,893E-03 0,01166674 ! ribosome assembly GO:0042255 18 14 0,000 5,893E-03 0,0116573 ! cerebellum development GO:0021549 23 14 0,000 5,893E-03 0,01164786 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 5,893E-03 0,01163845 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 5,893E-03 0,01162905 ! negative regulation of protein secretion GO:0050709 30 14 0,000 5,893E-03 0,01161966 ! response to gamma radiation GO:0010332 30 14 0,000 5,893E-03 0,01161029 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 5,893E-03 0,01160093 ! NADP metabolic process GO:0006739 24 14 0,000 5,893E-03 0,01159159 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 5,893E-03 0,01158227 ! oxygen transport GO:0015671 22 14 0,000 5,893E-03 0,01157296 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 5,893E-03 0,01156366 ! male genitalia development GO:0030539 26 14 0,000 5,893E-03 0,01155438 ! regulation of RNA stability GO:0043487 33 14 0,000 5,893E-03 0,01154512 ! regulation of axon extension GO:0030516 43 14 0,000 5,893E-03 0,01153586 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 5,893E-03 0,01152663 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 5,893E-03 0,01151741 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 5,893E-03 0,0115082 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 6,313E-03 0,01231794 ! lactation GO:0007595 30 15 0,000 6,313E-03 0,01230811 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 6,313E-03 0,0122983 ! reproductive cellular process GO:0048610 22 15 0,000 6,313E-03 0,0122885 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 6,313E-03 0,01227871 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 6,313E-03 0,01226894 ! superoxide anion generation GO:0042554 22 15 0,000 6,313E-03 0,01225919 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 6,313E-03 0,01224945 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 6,313E-03 0,01223973 ! phospholipid catabolic process GO:0009395 27 15 0,000 6,313E-03 0,01223003 ! copper ion transport GO:0006825 22 15 0,000 6,313E-03 0,01222034 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 6,313E-03 0,01221066 ! cardiac muscle contraction GO:0060048 28 15 0,000 6,313E-03 0,012201 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 6,313E-03 0,01219135 ! sulfate transport GO:0008272 27 15 0,000 6,313E-03 0,01218172 ! response to cAMP GO:0051591 25 15 0,000 6,313E-03 0,01217211 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 6,313E-03 0,01216251 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 6,313E-03 0,01215293 ! regulation of mRNA processing GO:0050684 26 15 0,000 6,313E-03 0,01214336 ! response to hexose stimulus GO:0009746 25 15 0,000 6,313E-03 0,0121338 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 6,313E-03 0,01212426 ! glycoprotein catabolic process GO:0006516 33 15 0,000 6,313E-03 0,01211474 ! vesicle coating GO:0006901 38 15 0,000 6,313E-03 0,01210523 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 6,313E-03 0,01209574 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 6,313E-03 0,01208626 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 6,313E-03 0,01207679 ! regulation of exocytosis GO:0017157 26 15 0,000 6,313E-03 0,01206734 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 6,313E-03 0,01205791 ! G1/S transition checkpoint GO:0031575 37 15 0,000 6,313E-03 0,01204849 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 6,313E-03 0,01203908 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 6,313E-03 0,01202969 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 6,313E-03 0,01202031 ! regulation of vasodilation GO:0042312 27 15 0,000 6,313E-03 0,01201095 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 6,313E-03 0,01200161 ! histone deacetylation GO:0016575 24 15 0,000 6,313E-03 0,01199227 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 6,313E-03 0,01198296 ! water homeostasis GO:0030104 28 15 0,000 6,313E-03 0,01197365 ! cofactor transport GO:0051181 30 15 0,000 6,313E-03 0,01196436 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 6,313E-03 0,01195509 ! muscle maintenance GO:0046716 26 15 0,000 6,313E-03 0,01194583 ! protein-chromophore linkage GO:0018298 25 15 0,000 6,313E-03 0,01193658 ! intestinal absorption GO:0050892 31 15 0,000 6,313E-03 0,01192735 ! dopamine metabolic process GO:0042417 35 15 0,000 6,313E-03 0,01191813 ! cAMP biosynthetic process GO:0006171 25 15 0,000 6,313E-03 0,01190893 ! heme biosynthetic process GO:0006783 33 15 0,000 6,313E-03 0,01189974 ! cell killing GO:0001906 32 15 0,000 6,313E-03 0,01189057 ! lymphocyte homeostasis GO:0002260 33 15 0,000 6,313E-03 0,0118814 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 6,313E-03 0,01187226 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 6,313E-03 0,01186313 ! L-fucose metabolic process GO:0042354 33 15 0,000 6,313E-03 0,01185401 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 6,313E-03 0,0118449 ! actin filament polymerization GO:0030041 27 15 0,000 6,313E-03 0,01183581 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 6,313E-03 0,01182674 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 6,732E-03 0,01260304 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 6,732E-03 0,01259339 ! positive regulation of cell size GO:0045793 29 16 0,000 6,732E-03 0,01258375 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 6,732E-03 0,01257413 ! dicarboxylic acid transport GO:0006835 47 16 0,000 6,732E-03 0,01256453 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 6,732E-03 0,01255493 ! bone remodeling GO:0046849 28 16 0,000 6,732E-03 0,01254536 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 6,732E-03 0,0125358 ! heterophilic cell adhesion GO:0007157 43 16 0,000 6,732E-03 0,01252625 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 6,732E-03 0,01251671 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 6,732E-03 0,0125072 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 6,732E-03 0,01249769 ! positive regulation of ion transport GO:0043270 23 16 0,000 6,732E-03 0,0124882 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 6,732E-03 0,01247873 ! startle response GO:0001964 28 16 0,000 6,732E-03 0,01246927 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 6,732E-03 0,01245982 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 6,732E-03 0,01245039 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 6,732E-03 0,01244097 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 6,732E-03 0,01243157 ! protein polyubiquitination GO:0000209 41 16 0,000 6,732E-03 0,01242218 ! glutamate metabolic process GO:0006536 25 16 0,000 6,732E-03 0,0124128 ! pituitary gland development GO:0021983 30 16 0,000 6,732E-03 0,01240344 ! response to osmotic stress GO:0006970 27 16 0,000 6,732E-03 0,01239409 ! lysosomal transport GO:0007041 31 16 0,000 6,732E-03 0,01238476 ! fructose metabolic process GO:0006000 25 16 0,000 6,732E-03 0,01237544 ! L-amino acid transport GO:0015807 33 16 0,000 6,732E-03 0,01236614 ! stem cell development GO:0048864 46 16 0,000 6,732E-03 0,01235685 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 6,732E-03 0,01234757 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 6,732E-03 0,01233831 ! intermediate filament-based process GO:0045103 36 16 0,000 6,732E-03 0,01232906 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 6,732E-03 0,01231982 ! negative regulation of immune response GO:0050777 38 16 0,000 6,732E-03 0,0123106 ! axon cargo transport GO:0008088 46 16 0,000 6,732E-03 0,01230139 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 6,732E-03 0,0122922 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 6,732E-03 0,01228302 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 6,732E-03 0,01227385 ! DNA replication initiation GO:0006270 28 16 0,000 6,732E-03 0,0122647 ! neuron recognition GO:0008038 40 16 0,000 6,732E-03 0,01225556 ! mRNA splice site selection GO:0006376 44 16 0,000 6,732E-03 0,01224644 ! tissue regeneration GO:0042246 27 16 0,000 6,732E-03 0,01223732 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 6,732E-03 0,01222823 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 6,732E-03 0,01221914 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 6,732E-03 0,01221007 ! biomineral formation GO:0031214 22 16 0,000 6,732E-03 0,01220101 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 6,732E-03 0,01219197 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 6,732E-03 0,01218294 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 6,732E-03 0,01217392 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 6,732E-03 0,01216491 ! regulation of ATPase activity GO:0043462 26 16 0,000 6,732E-03 0,01215592 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 6,732E-03 0,01214694 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 6,732E-03 0,01213798 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 6,732E-03 0,01212903 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 6,732E-03 0,01212009 ! peptide hormone processing GO:0016486 27 16 0,000 6,732E-03 0,01211117 ! positive regulation of cell killing GO:0031343 36 17 0,000 7,152E-03 0,01285611 ! metencephalon development GO:0022037 32 17 0,000 7,152E-03 0,01284666 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 7,152E-03 0,01283722 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 7,152E-03 0,0128278 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 7,152E-03 0,01281839 ! signal complex assembly GO:0007172 47 17 0,000 7,152E-03 0,01280899 ! filopodium assembly GO:0046847 42 17 0,000 7,152E-03 0,0127996 ! endothelial cell migration GO:0043542 31 17 0,000 7,152E-03 0,01279023 ! gene silencing by RNA GO:0031047 38 17 0,000 7,152E-03 0,01278088 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 7,152E-03 0,01277153 ! glial cell development GO:0021782 28 17 0,000 7,152E-03 0,01276221 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 7,152E-03 0,01275289 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 7,152E-03 0,01274359 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 7,152E-03 0,0127343 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 7,152E-03 0,01272503 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 7,152E-03 0,01271576 ! myoblast differentiation GO:0045445 50 17 0,000 7,152E-03 0,01270652 ! activation of MAPKK activity GO:0000186 43 17 0,000 7,152E-03 0,01269728 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 7,152E-03 0,01268806 ! regulation of survival gene product expression GO:0045884 38 17 0,000 7,152E-03 0,01267885 ! cardiac muscle tissue development GO:0048738 34 17 0,000 7,152E-03 0,01266966 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 7,152E-03 0,01266048 ! complement activation, alternative pathway GO:0006957 19 17 0,000 7,152E-03 0,01265131 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 7,152E-03 0,01264216 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 7,152E-03 0,01263301 ! membrane budding GO:0006900 42 17 0,000 7,152E-03 0,01262389 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 7,152E-03 0,01261477 ! regulation of protein binding GO:0043393 33 17 0,000 7,152E-03 0,01260567 ! nucleobase metabolic process GO:0009112 43 17 0,000 7,152E-03 0,01259658 ! DNA unwinding during replication GO:0006268 26 17 0,000 7,152E-03 0,01258751 ! genitalia development GO:0048806 32 17 0,000 7,152E-03 0,01257844 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 7,152E-03 0,0125694 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 7,152E-03 0,01256036 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 7,152E-03 0,01255134 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 7,152E-03 0,01254233 ! neutrophil chemotaxis GO:0030593 29 17 0,000 7,152E-03 0,01253333 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 7,152E-03 0,01252434 ! steroid catabolic process GO:0006706 34 17 0,000 7,152E-03 0,01251537 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 7,152E-03 0,01250641 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 7,152E-03 0,01249747 ! gas transport GO:0015669 26 17 0,000 7,152E-03 0,01248853 ! organic cation transport GO:0015695 32 17 0,000 7,152E-03 0,01247961 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 7,152E-03 0,01247071 ! RNA 3'-end processing GO:0031123 37 17 0,000 7,152E-03 0,01246181 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 7,152E-03 0,01245293 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 7,571E-03 0,01317347 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 7,571E-03 0,01316409 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 7,571E-03 0,01315473 ! limbic system development GO:0021761 40 18 0,000 7,571E-03 0,01314538 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 7,571E-03 0,01313605 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 7,571E-03 0,01312672 ! adult walking behavior GO:0007628 36 18 0,000 7,571E-03 0,01311741 ! patterning of blood vessels GO:0001569 43 18 0,000 7,571E-03 0,01310812 ! heart looping GO:0001947 34 18 0,000 7,571E-03 0,01309883 ! ciliary or flagellar motility GO:0001539 32 18 0,000 7,571E-03 0,01308956 ! regulation of viral genome replication GO:0045069 30 18 0,000 7,571E-03 0,01308031 ! centrosome cycle GO:0007098 26 18 0,000 7,571E-03 0,01307106 ! positive regulation of proteolysis GO:0045862 36 18 0,000 7,571E-03 0,01306183 ! regulation of defense response to virus GO:0050688 35 18 0,000 7,571E-03 0,01305261 ! epidermis morphogenesis GO:0048730 43 18 0,000 7,571E-03 0,01304341 ! glycine metabolic process GO:0006544 30 18 0,000 7,571E-03 0,01303422 ! glutamine metabolic process GO:0006541 29 18 0,000 7,571E-03 0,01302504 ! response to retinoic acid GO:0032526 31 18 0,000 7,571E-03 0,01301587 ! cell-substrate junction assembly GO:0007044 56 18 0,000 7,571E-03 0,01300672 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 0,000 7,571E-03 0,01299758 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 7,571E-03 0,01298845 ! DNA integration GO:0015074 32 18 0,000 7,571E-03 0,01297933 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 7,571E-03 0,01297023 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 7,571E-03 0,01296114 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 7,571E-03 0,01295207 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 7,571E-03 0,012943 ! neural crest cell migration GO:0001755 41 18 0,000 7,571E-03 0,01293395 ! long-chain fatty acid transport GO:0015909 32 18 0,000 7,571E-03 0,01292491 ! sphingolipid catabolic process GO:0030149 32 18 0,000 7,571E-03 0,01291589 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 7,571E-03 0,01290687 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 7,571E-03 0,01289787 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 7,571E-03 0,01288889 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 7,571E-03 0,01287991 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 7,571E-03 0,01287095 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 7,571E-03 0,012862 ! detection of bacterium GO:0016045 22 18 0,000 7,571E-03 0,01285306 ! nerve development GO:0021675 34 18 0,000 7,571E-03 0,01284413 ! defense response to virus GO:0051607 43 18 0,000 7,571E-03 0,01283522 ! microspike assembly GO:0030035 46 18 0,000 7,571E-03 0,01282632 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 7,571E-03 0,01281743 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 7,571E-03 0,01280855 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 7,99E-03 0,01350812 ! positive regulation of translation GO:0045727 31 19 0,000 7,99E-03 0,01349878 ! negative regulation of defense response GO:0031348 27 19 0,000 7,99E-03 0,01348945 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 7,99E-03 0,01348014 ! neuron maturation GO:0042551 46 19 0,000 7,99E-03 0,01347084 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 7,99E-03 0,01346155 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 7,99E-03 0,01345227 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 7,99E-03 0,013443 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 7,99E-03 0,01343375 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 7,99E-03 0,01342451 ! inositol metabolic process GO:0006020 33 19 0,000 7,99E-03 0,01341529 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 7,99E-03 0,01340607 ! memory GO:0007613 34 19 0,000 7,99E-03 0,01339687 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 7,99E-03 0,01338768 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 7,99E-03 0,01337851 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 7,99E-03 0,01336934 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 7,99E-03 0,01336019 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 7,99E-03 0,01335105 ! cerebral cortex development GO:0021987 40 19 0,000 7,99E-03 0,01334193 ! pigmentation during development GO:0048066 42 19 0,000 7,99E-03 0,01333281 ! response to vitamin A GO:0033189 32 19 0,000 7,99E-03 0,01332371 ! heme metabolic process GO:0042168 40 19 0,000 7,99E-03 0,01331463 ! neuromuscular junction development GO:0007528 43 19 0,000 7,99E-03 0,01330555 ! response to lipopolysaccharide GO:0032496 34 19 0,000 7,99E-03 0,01329649 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 7,99E-03 0,01328743 ! response to fungus GO:0009620 26 19 0,000 7,99E-03 0,01327839 ! peptide cross-linking GO:0018149 39 19 0,000 7,99E-03 0,01326937 ! protein export from nucleus GO:0006611 40 19 0,000 7,99E-03 0,01326035 ! heart process GO:0003015 32 19 0,000 7,99E-03 0,01325135 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 7,99E-03 0,01324236 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 7,99E-03 0,01323338 ! visual learning GO:0008542 38 19 0,000 7,99E-03 0,01322442 ! cellular pigmentation GO:0033059 37 19 0,000 7,99E-03 0,01321546 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 7,99E-03 0,01320652 ! peptide biosynthetic process GO:0043043 26 19 0,000 7,99E-03 0,01319759 ! vitamin transport GO:0051180 31 19 0,000 7,99E-03 0,01318868 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 7,99E-03 0,01317977 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 7,99E-03 0,01317088 ! proximal/distal pattern formation GO:0009954 33 19 0,000 7,99E-03 0,013162 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 7,99E-03 0,01315313 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 7,99E-03 0,01314427 ! cilium assembly GO:0042384 38 19 0,000 7,99E-03 0,01313542 ! peptide hormone secretion GO:0030072 32 19 0,000 7,99E-03 0,01312659 ! protein secretion GO:0009306 45 20 0,000 8,409E-03 0,01380546 ! protein import into nucleus, docking GO:0000059 42 20 0,000 8,409E-03 0,01379619 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 8,409E-03 0,01378693 ! positive regulation of ossification GO:0045778 50 20 0,000 8,409E-03 0,01377768 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 8,409E-03 0,01376845 ! skin development GO:0043588 42 20 0,000 8,409E-03 0,01375923 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 8,409E-03 0,01375002 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 8,409E-03 0,01374082 ! protein amino acid deacetylation GO:0006476 34 20 0,000 8,409E-03 0,01373163 ! protein amino acid acetylation GO:0006473 41 20 0,000 8,409E-03 0,01372246 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 8,409E-03 0,0137133 ! aminoglycan catabolic process GO:0006026 25 20 0,000 8,409E-03 0,01370415 ! response to vitamin GO:0033273 36 20 0,000 8,409E-03 0,01369502 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 8,409E-03 0,01368589 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 8,409E-03 0,01367678 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 8,409E-03 0,01366768 ! bile acid metabolic process GO:0008206 34 20 0,000 8,409E-03 0,01365859 ! response to alkaloid GO:0043279 38 20 0,000 8,409E-03 0,01364952 ! retinoid metabolic process GO:0001523 34 20 0,000 8,409E-03 0,01364046 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 8,409E-03 0,0136314 ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 8,409E-03 0,01362236 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 8,409E-03 0,01361334 ! DNA duplex unwinding GO:0032508 30 20 0,000 8,409E-03 0,01360432 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 8,409E-03 0,01359532 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 8,409E-03 0,01358633 ! actin filament bundle formation GO:0051017 47 20 0,000 8,409E-03 0,01357735 ! body fluid secretion GO:0007589 33 20 0,000 8,409E-03 0,01356838 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 8,409E-03 0,01355942 ! peptide secretion GO:0002790 38 20 0,000 8,409E-03 0,01355048 ! behavioral interaction between organisms GO:0051705 47 20 0,000 8,409E-03 0,01354155 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 8,409E-03 0,01353263 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 8,409E-03 0,01352372 ! protein localization in mitochondrion GO:0070585 39 20 0,000 8,409E-03 0,01351482 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 8,409E-03 0,01350593 ! cell-cell junction organization GO:0045216 43 20 0,000 8,409E-03 0,01349706 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 8,409E-03 0,0134882 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 8,409E-03 0,01347935 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 8,409E-03 0,01347051 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 8,409E-03 0,01346168 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 8,409E-03 0,01345287 ! regulation of glucose import GO:0046324 30 20 0,000 8,409E-03 0,01344406 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 8,409E-03 0,01343527 ! negative regulation of T cell activation GO:0050868 41 20 0,000 8,409E-03 0,01342649 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 8,409E-03 0,01341772 ! negative regulation of translation GO:0017148 32 20 0,000 8,409E-03 0,01340896 ! negative regulation of coagulation GO:0050819 30 20 0,000 8,409E-03 0,01340021 ! regulation of cell killing GO:0031341 46 21 0,000 8,827E-03 0,01405828 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 8,827E-03 0,01404913 ! hormone secretion GO:0046879 39 21 0,000 8,827E-03 0,01403998 ! lipid phosphorylation GO:0046834 43 21 0,000 8,827E-03 0,01403084 ! cAMP metabolic process GO:0046058 41 21 0,000 8,827E-03 0,01402172 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 8,827E-03 0,01401261 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 8,827E-03 0,01400351 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 8,827E-03 0,01399442 ! ovarian follicle development GO:0001541 39 21 0,000 8,827E-03 0,01398535 ! smooth muscle contraction GO:0006939 48 21 0,000 8,827E-03 0,01397629 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 0,000 8,827E-03 0,01396723 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 8,827E-03 0,01395819 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 8,827E-03 0,01394916 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 8,827E-03 0,01394015 ! plasma membrane fusion GO:0045026 33 21 0,000 8,827E-03 0,01393114 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 8,827E-03 0,01392215 ! prostaglandin metabolic process GO:0006693 43 21 0,000 8,827E-03 0,01391317 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 8,827E-03 0,0139042 ! sensory perception of pain GO:0019233 33 21 0,000 8,827E-03 0,01389524 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 8,827E-03 0,01388629 ! diencephalon development GO:0021536 36 21 0,000 8,827E-03 0,01387735 ! collagen fibril organization GO:0030199 62 21 0,000 8,827E-03 0,01386843 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 8,827E-03 0,01385952 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 8,827E-03 0,01385062 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 8,827E-03 0,01384173 ! vitamin A metabolic process GO:0006776 35 21 0,000 8,827E-03 0,01383285 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 8,827E-03 0,01382398 ! collagen catabolic process GO:0030574 29 21 0,000 8,827E-03 0,01381512 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 8,827E-03 0,01380628 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 8,827E-03 0,01379745 ! sperm-egg recognition GO:0035036 23 21 0,000 8,827E-03 0,01378862 ! actin filament-based movement GO:0030048 47 21 0,000 8,827E-03 0,01377981 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 8,827E-03 0,01377101 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 9,246E-03 0,01441473 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 9,246E-03 0,01440554 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 9,246E-03 0,01439636 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 9,246E-03 0,01438719 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 9,246E-03 0,01437803 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 9,246E-03 0,01436888 ! microtubule-based transport GO:0010970 59 22 0,000 9,246E-03 0,01435975 ! hindlimb morphogenesis GO:0035137 47 22 0,000 9,246E-03 0,01435063 ! glutamate signaling pathway GO:0007215 48 22 0,000 9,246E-03 0,01434152 ! inactivation of MAPK activity GO:0000188 45 22 0,000 9,246E-03 0,01433242 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 9,246E-03 0,01432333 ! cellular response to starvation GO:0009267 37 22 0,000 9,246E-03 0,01431425 ! vacuolar transport GO:0007034 41 22 0,000 9,246E-03 0,01430518 ! central nervous system neuron development GO:0021954 47 22 0,000 9,246E-03 0,01429613 ! fucose metabolic process GO:0006004 44 22 0,000 9,246E-03 0,01428709 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 9,246E-03 0,01427806 ! D-ribose metabolic process GO:0006014 36 22 0,000 9,246E-03 0,01426904 ! apoptotic nuclear changes GO:0030262 34 22 0,000 9,246E-03 0,01426003 ! ureteric bud development GO:0001657 50 22 0,000 9,246E-03 0,01425103 ! cell aging GO:0007569 48 22 0,000 9,246E-03 0,01424205 ! stem cell differentiation GO:0048863 57 22 0,000 9,246E-03 0,01423307 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 9,246E-03 0,01422411 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 9,246E-03 0,01421516 ! cytolysis GO:0019835 27 22 0,000 9,246E-03 0,01420622 ! renal system process GO:0003014 42 22 0,000 9,246E-03 0,01419729 ! vasodilation GO:0042311 40 22 0,000 9,246E-03 0,01418837 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 9,246E-03 0,01417946 ! positive regulation of locomotion GO:0040017 44 22 0,000 9,246E-03 0,01417057 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 9,246E-03 0,01416168 ! detection of chemical stimulus GO:0009593 42 22 0,000 9,246E-03 0,01415281 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 9,246E-03 0,01414395 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 9,246E-03 0,0141351 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 9,246E-03 0,01412626 ! peptidyl-serine modification GO:0018209 50 22 0,000 9,246E-03 0,01411743 ! regulation of cytokine secretion GO:0050707 41 22 0,000 9,246E-03 0,01410861 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 9,246E-03 0,0140998 ! sarcomere organization GO:0045214 32 22 0,000 9,246E-03 0,01409101 ! positive regulation of B cell activation GO:0050871 42 22 0,000 9,246E-03 0,01408222 ! response to cytokine stimulus GO:0034097 69 22 0,000 9,246E-03 0,01407345 ! activation of JUN kinase activity GO:0007257 47 22 0,000 9,246E-03 0,01406469 ! terpenoid metabolic process GO:0006721 40 22 0,000 9,246E-03 0,01405593 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 9,246E-03 0,01404719 ! gut development GO:0048565 44 22 0,000 9,246E-03 0,01403846 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 9,246E-03 0,01402974 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 9,246E-03 0,01402103 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 9,246E-03 0,01401234 ! protein stabilization GO:0050821 41 22 0,000 9,246E-03 0,01400365 ! positive regulation of DNA replication GO:0045740 44 23 0,000 9,664E-03 0,01462823 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 9,664E-03 0,01461917 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 9,664E-03 0,01461013 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 9,664E-03 0,01460109 ! gluconeogenesis GO:0006094 38 23 0,000 9,664E-03 0,01459207 ! glycerol metabolic process GO:0006071 40 23 0,000 9,664E-03 0,01458305 ! viral genome replication GO:0019079 44 23 0,000 9,664E-03 0,01457405 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 9,664E-03 0,01456506 ! glucosamine metabolic process GO:0006041 31 23 0,000 9,664E-03 0,01455608 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 9,664E-03 0,01454711 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 9,664E-03 0,01453815 ! regeneration GO:0031099 42 23 0,000 9,664E-03 0,01452921 ! axis specification GO:0009798 43 23 0,000 9,664E-03 0,01452027 ! visual behavior GO:0007632 46 23 0,000 9,664E-03 0,01451135 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 9,664E-03 0,01450243 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 9,664E-03 0,01449353 ! response to ethanol GO:0045471 47 23 0,000 9,664E-03 0,01448464 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 9,664E-03 0,01447576 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 9,664E-03 0,01446689 ! peroxisome organization GO:0007031 43 23 0,000 9,664E-03 0,01445803 ! lysosome organization GO:0007040 47 23 0,000 9,664E-03 0,01444918 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 9,664E-03 0,01444034 ! vesicle targeting GO:0006903 49 23 0,000 9,664E-03 0,01443152 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 9,664E-03 0,0144227 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 9,664E-03 0,0144139 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 9,664E-03 0,0144051 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 9,664E-03 0,01439632 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 9,664E-03 0,01438755 ! DNA modification GO:0006304 36 23 0,000 9,664E-03 0,01437878 ! fatty acid transport GO:0015908 47 23 0,000 9,664E-03 0,01437003 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 9,664E-03 0,01436129 ! regulation of bone mineralization GO:0030500 54 23 0,000 9,664E-03 0,01435256 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 9,664E-03 0,01434384 ! hormone transport GO:0009914 41 23 0,000 9,664E-03 0,01433513 ! cell-cell recognition GO:0009988 28 23 0,000 9,664E-03 0,01432643 ! negative regulation of cytokine production GO:0001818 41 23 0,000 9,664E-03 0,01431775 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 9,664E-03 0,01430907 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 9,664E-03 0,0143004 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,01008254 0,01491019 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,01008254 0,01490117 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,01008254 0,01489216 ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,01008254 0,01488316 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,01008254 0,01487418 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,01008254 0,0148652 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,01008254 0,01485623 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,01008254 0,01484728 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,01008254 0,01483833 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,01008254 0,0148294 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 0,000 0,01008254 0,01482048 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,01008254 0,01481157 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,01008254 0,01480267 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,01008254 0,01479378 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,01008254 0,0147849 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,01008254 0,01477603 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,01008254 0,01476717 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,01008254 0,01475832 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,01008254 0,01474948 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,01008254 0,01474066 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 52 24 0,000 0,01008254 0,01473184 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,01008254 0,01472303 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,01008254 0,01471424 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,01008254 0,01470545 ! membrane depolarization GO:0051899 45 24 0,000 0,01008254 0,01469668 ! pallium development GO:0021543 56 24 0,000 0,01008254 0,01468792 ! oogenesis GO:0048477 44 24 0,000 0,01008254 0,01467916 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,01008254 0,01467042 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,01008254 0,01466169 ! regulation of oxidoreductase activity GO:0051341 48 24 0,000 0,01008254 0,01465297 ! platelet activation GO:0030168 41 24 0,000 0,01008254 0,01464425 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,01008254 0,01463555 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,01008254 0,01462686 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,01008254 0,01461818 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,01008254 0,01460951 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,01008254 0,01460085 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,01008254 0,0145922 ! regulation of amine transport GO:0051952 41 24 0,000 0,01008254 0,01458356 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,01008254 0,01457493 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,01050058 0,01517026 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,01050058 0,01516129 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,01050058 0,01515234 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,01050058 0,01514339 ! leukocyte adhesion GO:0007159 55 25 0,000 0,01050058 0,01513446 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,01050058 0,01512553 ! phototransduction GO:0007602 37 25 0,000 0,01050058 0,01511662 ! keratinization GO:0031424 37 25 0,000 0,01050058 0,01510772 ! vasculogenesis GO:0001570 49 25 0,000 0,01050058 0,01509883 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,01050058 0,01508994 ! vacuole organization GO:0007033 49 25 0,000 0,01050058 0,01508107 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,01050058 0,01507221 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,01050058 0,01506336 ! receptor metabolic process GO:0043112 53 25 0,000 0,01050058 0,01505452 ! chromosome condensation GO:0030261 48 25 0,000 0,01050058 0,01504569 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,01050058 0,01503687 ! regulation of behavior GO:0050795 48 25 0,000 0,01050058 0,01502806 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,01050058 0,01501927 ! interaction with host GO:0051701 66 25 0,000 0,01050058 0,01501048 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,01050058 0,0150017 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,01050058 0,01499293 ! immunoglobulin production GO:0002377 62 25 0,000 0,01050058 0,01498417 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,01050058 0,01497543 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,01050058 0,01496669 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,01050058 0,01495796 ! liver development GO:0001889 55 25 0,000 0,01050058 0,01494925 ! protein tetramerization GO:0051262 57 25 0,000 0,01050058 0,01494054 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,01091845 0,01552606 ! myelination GO:0042552 50 26 0,000 0,01091845 0,01551703 ! initiation of viral infection GO:0019059 60 26 0,000 0,01091845 0,01550801 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,01091845 0,015499 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,01091845 0,01549 ! molting cycle process GO:0022404 52 26 0,000 0,01091845 0,01548101 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,01091845 0,01547203 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,01091845 0,01546306 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,01091845 0,0154541 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,01091845 0,01544515 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,01091845 0,01543621 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,01091845 0,01542728 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,01091845 0,01541837 ! digestive system process GO:0022600 49 26 0,000 0,01091845 0,01540946 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,01091845 0,01540056 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,01091845 0,01539168 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 0,000 0,01091845 0,0153828 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,01091845 0,01537393 ! osteoblast differentiation GO:0001649 63 26 0,000 0,01091845 0,01536508 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,01091845 0,01535623 ! neural crest cell development GO:0014032 59 26 0,000 0,01091845 0,0153474 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,01091845 0,01533857 ! negative regulation of cell development GO:0010721 83 26 0,000 0,01091845 0,01532976 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,01091845 0,01532095 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,01091845 0,01531216 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,01091845 0,01530337 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,01091845 0,0152946 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,01091845 0,01528583 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,01091845 0,01527708 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,01091845 0,01526833 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,01091845 0,0152596 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,01091845 0,01525087 ! blastocyst development GO:0001824 50 26 0,000 0,01091845 0,01524216 ! telomere organization GO:0032200 46 26 0,000 0,01091845 0,01523345 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,01091845 0,01522476 ! neural tube closure GO:0001843 58 26 0,000 0,01091845 0,01521607 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,01091845 0,0152074 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,01091845 0,01519873 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,01091845 0,01519008 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,01133616 0,01576223 ! embryonic pattern specification GO:0009880 49 27 0,000 0,01133616 0,01575326 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,01133616 0,01574431 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,01133616 0,01573536 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,01133616 0,01572643 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,01133616 0,0157175 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,01133616 0,01570859 ! iron ion transport GO:0006826 65 27 0,000 0,01133616 0,01569968 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,01133616 0,01569079 ! superoxide metabolic process GO:0006801 41 27 0,000 0,01133616 0,0156819 ! tube lumen formation GO:0035148 59 27 0,000 0,01133616 0,01567303 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,01133616 0,01566416 ! insulin receptor signaling pathway GO:0008286 66 27 0,000 0,01133616 0,01565531 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,01133616 0,01564646 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,01133616 0,01563763 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,01133616 0,0156288 ! response to starvation GO:0042594 47 27 0,000 0,01133616 0,01561999 ! response to toxin GO:0009636 49 27 0,000 0,01133616 0,01561118 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,01133616 0,01560239 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,01133616 0,0155936 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,01133616 0,01558483 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,01133616 0,01557606 ! leukocyte proliferation GO:0070661 59 27 0,000 0,01133616 0,01556731 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,01133616 0,01555856 ! regulation of fibroblast proliferation GO:0048145 56 28 0,000 0,01175371 0,01612257 ! neuron fate commitment GO:0048663 52 28 0,000 0,01175371 0,01611353 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,01175371 0,01610449 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,01175371 0,01609546 ! protein amino acid acylation GO:0043543 59 28 0,000 0,01175371 0,01608644 ! vesicle docking GO:0048278 55 28 0,000 0,01175371 0,01607744 ! circadian rhythm GO:0007623 56 28 0,000 0,01175371 0,01606844 ! dendrite development GO:0016358 67 28 0,000 0,01175371 0,01605945 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,01175371 0,01605048 ! fat cell differentiation GO:0045444 57 28 0,000 0,01175371 0,01604151 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,01175371 0,01603255 ! sperm motility GO:0030317 37 28 0,000 0,01175371 0,01602361 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,01175371 0,01601467 ! base-excision repair GO:0006284 41 28 0,000 0,01175371 0,01600574 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,01175371 0,01599683 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,01175371 0,01598792 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,01175371 0,01597902 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,01175371 0,01597014 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,01175371 0,01596126 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,01175371 0,01595239 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,01175371 0,01594353 ! glutathione metabolic process GO:0006749 42 28 0,000 0,01175371 0,01593469 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,01175371 0,01592585 ! lipid oxidation GO:0034440 48 28 0,000 0,01175371 0,01591702 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,01175371 0,0159082 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,01175371 0,01589939 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,01217109 0,01645488 ! translational initiation GO:0006413 66 29 0,000 0,01217109 0,01644578 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,01217109 0,01643669 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,01217109 0,0164276 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,01217109 0,01641853 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,01217109 0,01640947 ! autophagy GO:0006914 47 29 0,000 0,01217109 0,01640042 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,01217109 0,01639138 ! primary neural tube formation GO:0014020 61 29 0,000 0,01217109 0,01638235 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,01217109 0,01637333 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,01217109 0,01636432 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,01217109 0,01635532 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,01217109 0,01634632 ! somitogenesis GO:0001756 52 29 0,000 0,01217109 0,01633734 ! synaptogenesis GO:0007416 46 29 0,000 0,01217109 0,01632837 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,01217109 0,01631941 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,01217109 0,01631046 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,01217109 0,01630152 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,01217109 0,01629258 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,0125883 0,01684185 ! phenol metabolic process GO:0018958 56 30 0,000 0,0125883 0,01683263 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,0125883 0,01682343 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,0125883 0,01681423 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,0125883 0,01680504 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,0125883 0,01679586 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,0125883 0,01678669 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,0125883 0,01677754 ! acute-phase response GO:0006953 50 30 0,000 0,0125883 0,01676839 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,0125883 0,01675925 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,0125883 0,01675012 ! myofibril assembly GO:0030239 50 30 0,000 0,0125883 0,016741 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,0125883 0,0167319 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,0125883 0,0167228 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,0125883 0,01671371 ! cell fate determination GO:0001709 64 30 0,000 0,0125883 0,01670463 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,0125883 0,01669556 ! phospholipid transport GO:0015914 65 30 0,000 0,0125883 0,0166865 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,0125883 0,01667745 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,0125883 0,01666841 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,0125883 0,01665938 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,0125883 0,01665036 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,0125883 0,01664135 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,0125883 0,01663235 ! regulation of coagulation GO:0050818 52 30 0,000 0,0125883 0,01662336 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,01300535 0,01716482 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,01300535 0,01715555 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,01300535 0,01714629 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,01300535 0,01713704 ! cell junction assembly GO:0034329 85 31 0,000 0,01300535 0,01712781 ! regulation of innate immune response GO:0045088 57 31 0,000 0,01300535 0,01711858 ! ovulation cycle process GO:0022602 55 31 0,000 0,01300535 0,01710936 ! peptide transport GO:0015833 60 31 0,000 0,01300535 0,01710015 ! male gonad development GO:0008584 56 31 0,000 0,01300535 0,01709095 ! iron ion homeostasis GO:0055072 60 31 0,000 0,01300535 0,01708176 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,01300535 0,01707258 ! detection of light stimulus GO:0009583 44 31 0,000 0,01300535 0,01706342 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,01300535 0,01705426 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,01300535 0,01704511 ! natural killer cell activation GO:0030101 50 31 0,000 0,01300535 0,01703597 ! ensheathment of neurons GO:0007272 64 31 0,000 0,01300535 0,01702684 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,01300535 0,01701772 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,01300535 0,01700861 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,01300535 0,01699951 ! eye morphogenesis GO:0048592 65 31 0,000 0,01300535 0,01699042 ! response to heat GO:0009408 54 31 0,000 0,01300535 0,01698134 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,01300535 0,01697227 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,01342224 0,01750696 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,01342224 0,01749762 ! collagen metabolic process GO:0032963 49 32 0,000 0,01342224 0,01748829 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,01342224 0,01747896 ! spindle organization GO:0007051 50 32 0,000 0,01342224 0,01746965 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,01342224 0,01746035 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,01342224 0,01745106 ! metanephros development GO:0001656 81 32 0,000 0,01342224 0,01744177 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,01342224 0,0174325 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,01342224 0,01742324 ! muscle cell development GO:0055001 52 32 0,000 0,01342224 0,01741399 ! mesoderm formation GO:0001707 73 32 0,000 0,01342224 0,01740474 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,01342224 0,01739551 ! ovulation cycle GO:0042698 57 32 0,000 0,01342224 0,01738629 ! peripheral nervous system development GO:0007422 68 32 0,000 0,01342224 0,01737707 ! BMP signaling pathway GO:0030509 71 32 0,000 0,01342224 0,01736787 ! hindbrain development GO:0030902 65 32 0,000 0,01342224 0,01735867 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,01342224 0,01734949 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,01342224 0,01734032 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,01342224 0,01733115 ! gene silencing GO:0016458 71 32 0,000 0,01342224 0,01732199 ! regulation of pH GO:0006885 56 33 0,000 0,01383896 0,01785036 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,01383896 0,01784094 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,01383896 0,01783154 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,01383896 0,01782214 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,01383896 0,01781275 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,01383896 0,01780337 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,01383896 0,017794 ! response to ionizing radiation GO:0010212 74 33 0,000 0,01383896 0,01778463 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,01383896 0,01777528 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,01383896 0,01776594 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,01383896 0,01775661 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,01383896 0,01774729 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,01383896 0,01773798 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,01383896 0,01772868 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,01383896 0,01771939 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,01425552 0,01824319 ! glial cell differentiation GO:0010001 67 34 0,000 0,01425552 0,01823364 ! post-embryonic development GO:0009791 76 34 0,000 0,01425552 0,01822409 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,01425552 0,01821456 ! cholesterol transport GO:0030301 62 34 0,000 0,01425552 0,01820504 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,01425552 0,01819553 ! spliceosome assembly GO:0000245 75 34 0,000 0,01425552 0,01818603 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,01425552 0,01817654 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,01425552 0,01816705 ! formation of primary germ layer GO:0001704 76 34 0,000 0,01425552 0,01815758 ! cell fate specification GO:0001708 56 34 0,000 0,01425552 0,01814812 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,01425552 0,01813867 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,01425552 0,01812923 ! adult locomotory behavior GO:0008344 62 34 0,000 0,01425552 0,01811979 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,01425552 0,01811037 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,01467192 0,01862968 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,01467192 0,01862 ! negative regulation of secretion GO:0051048 68 35 0,000 0,01467192 0,01861033 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,01467192 0,01860067 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,01467192 0,01859102 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,01467192 0,01858139 ! membrane docking GO:0022406 69 35 0,000 0,01467192 0,01857176 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,01467192 0,01856214 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,01467192 0,01855253 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,01467192 0,01854294 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,01467192 0,01853335 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,01467192 0,01852377 ! ceramide metabolic process GO:0006672 72 35 0,000 0,01467192 0,0185142 ! telencephalon development GO:0021537 81 35 0,000 0,01467192 0,01850464 ! sterol transport GO:0015918 63 35 0,000 0,01467192 0,0184951 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,01467192 0,01848556 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,01467192 0,01847603 ! placenta development GO:0001890 53 35 0,000 0,01467192 0,01846651 ! vesicle localization GO:0051648 70 35 0,000 0,01467192 0,018457 ! regulation of muscle development GO:0048634 82 36 0,000 0,01508815 0,01897084 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,01508815 0,01896108 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,01508815 0,01895133 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,01508815 0,0189416 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,01508815 0,01893187 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,01508815 0,01892215 ! positive regulation of cell development GO:0010720 85 36 0,000 0,01508815 0,01891244 ! protein targeting to membrane GO:0006612 75 36 0,000 0,01508815 0,01890274 ! regulation of proteolysis GO:0030162 77 36 0,000 0,01508815 0,01889305 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,01508815 0,01888337 ! aerobic respiration GO:0009060 56 36 0,000 0,01508815 0,0188737 ! cytokine production GO:0001816 68 36 0,000 0,01508815 0,01886405 ! embryonic organ development GO:0048568 67 36 0,000 0,01508815 0,0188544 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,01508815 0,01884476 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,01508815 0,01883513 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,01550421 0,01934464 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,01550421 0,01933476 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,01550421 0,0193249 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,01550421 0,01931504 ! sister chromatid segregation GO:0000819 65 37 0,000 0,01550421 0,0193052 ! odontogenesis GO:0042476 74 37 0,000 0,01550421 0,01929536 ! actomyosin structure organization GO:0031032 68 37 0,000 0,01550421 0,01928554 ! cell junction organization GO:0034330 96 37 0,000 0,01550421 0,01927572 ! tissue remodeling GO:0048771 78 37 0,000 0,01550421 0,01926592 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,01550421 0,01925612 ! female gonad development GO:0008585 71 37 0,000 0,01550421 0,01924634 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,01550421 0,01923656 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,01550421 0,0192268 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,01550421 0,01921704 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,01550421 0,0192073 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,01592012 0,01971254 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,01592012 0,01970256 ! meiosis I GO:0007127 74 38 0,000 0,01592012 0,01969258 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,01592012 0,01968261 ! organic anion transport GO:0015711 82 38 0,000 0,01592012 0,01967266 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,01592012 0,01966271 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,01592012 0,01965278 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,01592012 0,01964285 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,01592012 0,01963294 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,01592012 0,01962303 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,01592012 0,01961313 ! regulation of protein stability GO:0031647 77 38 0,000 0,01592012 0,01960325 ! spermatid development GO:0007286 69 38 0,000 0,01592012 0,01959337 ! glycogen metabolic process GO:0005977 63 38 0,000 0,01592012 0,01958351 ! pigment metabolic process GO:0042440 87 38 0,000 0,01592012 0,01957365 ! cellular response to insulin stimulus GO:0032869 85 38 0,000 0,01592012 0,0195638 ! neural tube formation GO:0001841 79 38 0,000 0,01592012 0,01955397 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,01633585 0,02005452 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,01633585 0,02004445 ! negative regulation of binding GO:0051100 71 39 0,000 0,01633585 0,02003438 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,01633585 0,02002433 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,01633585 0,02001429 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,01633585 0,02000426 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,01633585 0,01999423 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,01633585 0,01998422 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,01633585 0,01997422 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,01633585 0,01996423 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,01633585 0,01995425 ! glucan metabolic process GO:0044042 64 39 0,000 0,01633585 0,01994427 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,01675143 0,02044143 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,01675143 0,02043122 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,01675143 0,02042103 ! learning GO:0007612 82 40 0,000 0,01675143 0,02041084 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,01675143 0,02040067 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,01675143 0,0203905 ! lipid homeostasis GO:0055088 75 40 0,000 0,01675143 0,02038035 ! mismatch repair GO:0006298 58 40 0,000 0,01675143 0,0203702 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,01675143 0,02036007 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,01675143 0,02034995 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,01675143 0,02033983 ! RNA export from nucleus GO:0006405 61 41 0,000 0,01716684 0,02083387 ! mRNA catabolic process GO:0006402 79 41 0,000 0,01716684 0,02082353 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,01716684 0,02081319 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,01716684 0,02080287 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,01716684 0,02079256 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,01716684 0,02078225 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,01716684 0,02077196 ! gliogenesis GO:0042063 91 41 0,000 0,01716684 0,02076168 ! feeding behavior GO:0007631 69 41 0,000 0,01716684 0,0207514 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,01716684 0,02074114 ! mesenchymal cell development GO:0014031 94 41 0,000 0,01716684 0,02073089 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,01716684 0,02072065 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,01716684 0,02071041 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,01716684 0,02070019 ! spermatid differentiation GO:0048515 73 41 0,000 0,01716684 0,02068998 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,01716684 0,02067978 ! RNA modification GO:0009451 64 41 0,000 0,01716684 0,02066958 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,01758209 0,02115913 ! ear morphogenesis GO:0042471 64 42 0,000 0,01758209 0,02114871 ! organic ether metabolic process GO:0018904 59 42 0,000 0,01758209 0,0211383 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,01758209 0,02112791 ! regulation of intracellular protein transport GO:0033157 86 42 0,000 0,01758209 0,02111752 ! T cell differentiation GO:0030217 93 42 0,000 0,01758209 0,02110714 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,01758209 0,02109678 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,01758209 0,02108642 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,01758209 0,02107607 ! regulation of protein secretion GO:0050708 77 42 0,000 0,01758209 0,02106574 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,01758209 0,02105541 ! cytokinesis GO:0000910 84 42 0,000 0,01758209 0,02104509 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,01758209 0,02103479 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,01799717 0,02152084 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 0,000 0,01799717 0,02151031 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,01799717 0,0214998 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,01799717 0,02148929 ! regulation of tube size GO:0035150 76 43 0,000 0,01799717 0,02147879 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,01799717 0,0214683 ! glucose transport GO:0015758 66 43 0,000 0,01799717 0,02145782 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,01799717 0,02144736 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,01799717 0,0214369 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,01799717 0,02142645 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,01799717 0,02141602 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,01799717 0,02140559 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,01799717 0,02139517 ! segmentation GO:0035282 78 43 0,000 0,01799717 0,02138477 ! ion transmembrane transport GO:0034220 79 43 0,000 0,01799717 0,02137437 ! neuron migration GO:0001764 85 43 0,000 0,01799717 0,02136399 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,01799717 0,02135361 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,01841209 0,02183531 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,01841209 0,02182471 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,01841209 0,02181413 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,01841209 0,02180355 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,01841209 0,02179299 ! hexose transport GO:0008645 68 44 0,000 0,01841209 0,02178244 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,01841209 0,02177189 ! striated muscle contraction GO:0006941 85 44 0,000 0,01841209 0,02176136 ! phagocytosis GO:0006909 105 44 0,000 0,01841209 0,02175084 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,01841209 0,02174032 ! double-strand break repair GO:0006302 85 44 0,000 0,01841209 0,02172982 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,01882684 0,02220858 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,01882684 0,02219787 ! regulation of epithelial cell proliferation GO:0050678 122 45 0,000 0,01882684 0,02218716 ! induction of apoptosis by intracellular signals GO:0008629 95 45 0,000 0,01882684 0,02217646 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,01882684 0,02216577 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,01882684 0,02215509 ! biopolymer methylation GO:0043414 91 45 0,000 0,01882684 0,02214443 ! B cell differentiation GO:0030183 124 45 0,000 0,01882684 0,02213377 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,01882684 0,02212313 ! female gamete generation GO:0007292 71 45 0,000 0,01882684 0,02211249 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,01882684 0,02210186 ! polyol metabolic process GO:0019751 77 45 0,000 0,01882684 0,02209125 ! developmental growth GO:0048589 88 45 0,000 0,01882684 0,02208064 ! maintenance of location in cell GO:0051651 101 45 0,000 0,01882684 0,02207005 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,01924143 0,02254524 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,01924143 0,02253443 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 0,000 0,01924143 0,02252363 ! glycolysis GO:0006096 71 46 0,000 0,01924143 0,02251285 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 0,000 0,01924143 0,02250207 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,01924143 0,0224913 ! leukocyte migration GO:0050900 75 46 0,000 0,01924143 0,02248055 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,01924143 0,0224698 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,01924143 0,02245907 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,01924143 0,02244834 ! pigmentation GO:0043473 103 46 0,000 0,01924143 0,02243763 ! cell growth GO:0016049 90 46 0,000 0,01924143 0,02242692 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,01924143 0,02241623 ! neural tube development GO:0021915 91 47 0,000 0,01965586 0,02288812 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,01965586 0,02287721 ! response to insulin stimulus GO:0032868 98 47 0,000 0,01965586 0,02286632 ! positive regulation of cell cycle GO:0045787 96 48 0,000 0,02007013 0,02333714 ! positive regulation of defense response GO:0031349 88 48 0,000 0,02007013 0,02332603 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,02007013 0,02331494 ! mitochondrial transport GO:0006839 94 48 0,000 0,02007013 0,02330386 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,02007013 0,02329279 ! cellular component disassembly GO:0022411 89 48 0,000 0,02007013 0,02328173 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,02007013 0,02327068 ! endosome transport GO:0016197 127 48 0,000 0,02007013 0,02325964 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,02007013 0,02324861 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,02007013 0,02323759 ! male sex differentiation GO:0046661 93 48 0,000 0,02007013 0,02322659 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,02007013 0,02321559 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,02007013 0,0232046 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,02007013 0,02319362 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,02007013 0,02318266 ! methylation GO:0032259 97 48 0,000 0,02007013 0,0231717 ! response to calcium ion GO:0051592 94 49 0,000 0,02048423 0,02363863 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,02048423 0,02362747 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,02048423 0,02361632 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,02048423 0,02360518 ! JNK cascade GO:0007254 106 49 0,000 0,02048423 0,02359405 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,02048423 0,02358293 ! protein homooligomerization GO:0051260 84 49 0,000 0,02048423 0,02357182 ! regulation of action potential GO:0001508 102 50 0,000 0,02089817 0,02403683 ! regulation of ion transport GO:0043269 86 50 0,000 0,02089817 0,02402552 ! endocrine system development GO:0035270 109 50 0,000 0,02089817 0,02401422 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,02089817 0,02400293 ! activation of caspase activity GO:0006919 95 50 0,000 0,02089817 0,02399165 ! regulation of ossification GO:0030278 123 50 0,000 0,02089817 0,02398038 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,02089817 0,02396912 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,02089817 0,02395787 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,02089817 0,02394663 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,02089817 0,02393541 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,02089817 0,02392419 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,02131194 0,02438645 ! viral infectious cycle GO:0019058 104 51 0,000 0,02131194 0,02437504 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,02131194 0,02436363 ! peptide metabolic process GO:0006518 80 51 0,000 0,02131194 0,02435223 ! response to temperature stimulus GO:0009266 84 51 0,000 0,02131194 0,02434085 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,02131194 0,02432947 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,02131194 0,02431811 ! positive regulation of binding GO:0051099 88 52 0,000 0,02172555 0,02477849 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,02172555 0,02476693 ! Notch signaling pathway GO:0007219 111 52 0,000 0,02172555 0,02475538 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,02172555 0,02474384 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,02172555 0,02473231 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,02172555 0,02472079 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,02172555 0,02470928 ! excretion GO:0007588 87 52 0,000 0,02172555 0,02469778 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,02172555 0,02468629 ! histone modification GO:0016570 104 52 0,000 0,02172555 0,02467482 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,02172555 0,02466335 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,02172555 0,02465189 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,02172555 0,02464045 ! amino acid activation GO:0043038 98 52 0,000 0,02172555 0,02462902 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,022139 0,02508608 ! positive regulation of growth GO:0045927 96 53 0,000 0,022139 0,02507445 ! inner ear development GO:0048839 89 53 0,000 0,022139 0,02506283 ! chromatin remodeling GO:0006338 122 53 0,000 0,022139 0,02505122 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,022139 0,02503962 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,022139 0,02502804 ! vesicle organization GO:0016050 127 53 0,000 0,022139 0,02501646 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,022139 0,02500489 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,022139 0,02499334 ! cartilage development GO:0051216 99 53 0,000 0,022139 0,02498179 ! synapse organization GO:0050808 102 53 0,000 0,022139 0,02497026 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,02255229 0,02542466 ! regulation of translational initiation GO:0006446 87 54 0,000 0,02255229 0,02541293 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,02255229 0,02540122 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,02255229 0,02538951 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,02255229 0,02537782 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,02255229 0,02536613 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,02255229 0,02535446 ! membrane fusion GO:0006944 122 54 0,000 0,02255229 0,0253428 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,02255229 0,02533115 ! covalent chromatin modification GO:0016569 115 54 0,000 0,02255229 0,0253195 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,02255229 0,02530787 ! regulation of cell shape GO:0008360 142 54 0,000 0,02255229 0,02529625 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,02255229 0,02528464 ! RNA catabolic process GO:0006401 103 55 0,000 0,02296541 0,02573601 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,02296541 0,02572421 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,02296541 0,02571242 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,02296541 0,02570064 ! cell recognition GO:0008037 98 55 0,000 0,02296541 0,02568887 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,02296541 0,02567712 ! cell maturation GO:0048469 107 55 0,000 0,02296541 0,02566537 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,02296541 0,02565363 ! response to UV GO:0009411 120 55 0,000 0,02296541 0,02564191 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,02296541 0,0256302 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,02337837 0,02607916 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,02337837 0,02606726 ! glucose catabolic process GO:0006007 88 56 0,000 0,02337837 0,02605536 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,02337837 0,02604348 ! regulation of DNA replication GO:0006275 105 56 0,000 0,02337837 0,02603161 ! RNA elongation GO:0006354 90 56 0,000 0,02337837 0,02601975 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 0,000 0,02379117 0,02646713 ! chloride transport GO:0006821 102 57 0,000 0,02379117 0,02645508 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,02379117 0,02644305 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,02379117 0,02643102 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 0,000 0,02379117 0,02641901 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,02379117 0,02640701 ! heart morphogenesis GO:0003007 105 57 0,000 0,02379117 0,02639501 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,02379117 0,02638303 ! regulation of intracellular transport GO:0032386 108 57 0,000 0,02379117 0,02637106 ! regulation of actin filament length GO:0030832 118 58 0,000 0,0242038 0,02681627 ! positive regulation of cell migration GO:0030335 137 58 0,000 0,0242038 0,02680412 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,0242038 0,02679197 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,0242038 0,02677984 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,0242038 0,02676772 ! aging GO:0007568 112 58 0,000 0,0242038 0,0267556 ! gastrulation GO:0007369 122 58 0,000 0,0242038 0,0267435 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,0242038 0,02673141 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,0242038 0,02671933 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,0242038 0,02670727 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,0242038 0,02669521 ! maintenance of location GO:0051235 124 58 0,000 0,0242038 0,02668316 ! nuclear export GO:0051168 110 59 0,000 0,02461627 0,02712564 ! establishment of organelle localization GO:0051656 122 59 0,000 0,02461627 0,02711341 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,02502858 0,02755512 ! lipid modification GO:0030258 112 60 0,000 0,02502858 0,02754271 ! DNA catabolic process GO:0006308 94 60 0,000 0,02502858 0,02753031 ! regulation of endocytosis GO:0030100 104 60 0,000 0,02502858 0,02751792 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,02502858 0,02750554 ! adult behavior GO:0030534 104 60 0,000 0,02502858 0,02749317 ! kidney development GO:0001822 133 60 0,000 0,02502858 0,02748082 ! positive regulation of secretion GO:0051047 110 61 0,000 0,02544073 0,0279208 ! regulation of cellular component size GO:0032535 125 61 0,000 0,02544073 0,02790826 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,02544073 0,02789573 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,02544073 0,02788322 ! regulation of heart contraction GO:0008016 123 61 0,000 0,02544073 0,02787071 ! camera-type eye development GO:0043010 126 61 0,000 0,02544073 0,02785822 ! proton transport GO:0015992 117 61 0,000 0,02544073 0,02784574 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,02544073 0,02783327 ! viral reproductive process GO:0022415 132 62 0,000 0,02585271 0,02827134 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,02585271 0,02825869 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,02585271 0,02824605 ! tRNA processing GO:0008033 102 62 0,000 0,02585271 0,02823342 ! regulation of homeostatic process GO:0032844 148 62 0,000 0,02585271 0,02822081 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,02626453 0,02865755 ! regulation of mitosis GO:0007088 112 63 0,000 0,02626453 0,02864475 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,02626453 0,02863197 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,02626453 0,0286192 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,02626453 0,02860644 ! hydrogen transport GO:0006818 121 64 0,000 0,02667619 0,02904186 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,02667619 0,02902892 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,02667619 0,02901599 ! protein amino acid autophosphorylation GO:0046777 157 64 0,000 0,02667619 0,02900308 ! response to peptide hormone stimulus GO:0043434 129 64 0,000 0,02667619 0,02899018 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,02708768 0,02942428 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,02708768 0,0294112 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,02708768 0,02939814 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,02708768 0,02938508 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,02708768 0,02937204 ! positive regulation of cell motion GO:0051272 157 65 0,000 0,02708768 0,02935901 ! ear development GO:0043583 114 66 0,000 0,02749901 0,02979162 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,02749901 0,02977841 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,02749901 0,02976522 ! gonad development GO:0008406 115 66 0,000 0,02749901 0,02975203 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,02749901 0,02973886 ! negative regulation of cell growth GO:0030308 142 67 0,000 0,02791019 0,03017017 ! activation of MAPK activity GO:0000187 124 67 0,000 0,02791019 0,03015683 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,02791019 0,03014349 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,02791019 0,03013017 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,02791019 0,03011687 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,02791019 0,03010357 ! secondary metabolic process GO:0019748 125 67 0,000 0,02791019 0,03009028 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,02791019 0,03007701 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,02832119 0,03050647 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,02832119 0,03049303 ! hexose catabolic process GO:0019320 113 68 0,000 0,02832119 0,03047959 ! extracellular matrix organization GO:0030198 146 68 0,000 0,02832119 0,03046617 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,02832119 0,03045276 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,02832119 0,03043937 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,02832119 0,03042598 ! viral reproduction GO:0016032 142 68 0,000 0,02832119 0,03041261 ! regulation of lipase activity GO:0060191 137 68 0,000 0,02832119 0,03039924 ! adaptive immune response GO:0002250 126 68 0,000 0,02832119 0,03038589 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 0,000 0,02832119 0,03037255 ! negative regulation of cell size GO:0045792 144 69 0,000 0,02873204 0,03079964 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,02873204 0,03078613 ! negative regulation of protein kinase activity GO:0006469 144 69 0,000 0,02873204 0,03077263 ! lung development GO:0030324 165 69 0,000 0,02873204 0,03075915 ! urogenital system development GO:0001655 149 69 0,000 0,02873204 0,03074567 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,02873204 0,03073221 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 0,000 0,02873204 0,03071876 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,02873204 0,03070533 ! developmental maturation GO:0021700 128 69 0,000 0,02873204 0,0306919 ! single fertilization GO:0007338 83 69 0,000 0,02873204 0,03067849 ! negative regulation of kinase activity GO:0033673 145 70 0,000 0,02914272 0,0311034 ! cell redox homeostasis GO:0045454 114 70 0,000 0,02914272 0,03108981 ! germ cell development GO:0007281 133 70 0,000 0,02914272 0,03107624 ! activation of immune response GO:0002253 120 70 0,000 0,02914272 0,03106269 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,02914272 0,03104914 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,02955325 0,03147279 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,02955325 0,03145908 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,02955325 0,03144538 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,02955325 0,03143169 ! appendage morphogenesis GO:0035107 150 72 0,000 0,02996361 0,03185426 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,02996361 0,0318404 ! respiratory tube development GO:0030323 171 72 0,000 0,02996361 0,03182656 ! actin filament organization GO:0007015 167 72 0,000 0,02996361 0,03181273 ! B cell activation GO:0042113 179 72 0,000 0,02996361 0,03179891 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,02996361 0,0317851 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,02996361 0,03177131 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,02996361 0,03175752 ! appendage development GO:0048736 151 73 0,000 0,0303738 0,03217832 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,0303738 0,03216437 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,0303738 0,03215044 ! regulation of immune effector process GO:0002697 156 73 0,000 0,0303738 0,03213651 ! acute inflammatory response GO:0002526 118 74 0,000 0,03078384 0,03255624 ! amino acid transport GO:0006865 148 74 0,000 0,03078384 0,03254216 ! regulation of caspase activity GO:0043281 136 74 0,000 0,03078384 0,03252808 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,03078384 0,03251402 ! negative regulation of transferase activity GO:0051348 155 74 0,000 0,03078384 0,03249997 ! respiratory system development GO:0060541 175 74 0,000 0,03078384 0,03248593 ! organelle localization GO:0051640 155 74 0,000 0,03078384 0,0324719 ! regulation of transcription factor activity GO:0051090 137 75 0,000 0,03119372 0,03289005 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 143 75 0,000 0,03119372 0,03287586 ! reproductive structure development GO:0048608 131 75 0,000 0,03119372 0,03286168 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,03119372 0,03284752 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,03119372 0,03283337 ! eye development GO:0001654 155 75 0,000 0,03119372 0,03281923 ! axon guidance GO:0007411 162 75 0,000 0,03119372 0,0328051 ! rhythmic process GO:0048511 142 75 0,000 0,03119372 0,03279098 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,03160343 0,03320739 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,03160343 0,03319311 ! learning or memory GO:0007611 161 76 0,000 0,03160343 0,03317885 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,03160343 0,03316459 ! regulation of blood pressure GO:0008217 134 76 0,000 0,03160343 0,03315035 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,03160343 0,03313613 ! amine catabolic process GO:0009310 136 77 0,000 0,03201298 0,03355114 ! neurotransmitter transport GO:0006836 142 77 0,000 0,03201298 0,03353675 ! phosphoinositide metabolic process GO:0030384 146 77 0,000 0,03201298 0,03352238 ! regulation of endopeptidase activity GO:0052548 141 77 0,000 0,03201298 0,03350801 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,03201298 0,03349366 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,03201298 0,03347933 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,03201298 0,033465 ! regulation of catabolic process GO:0009894 173 77 0,000 0,03201298 0,03345069 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,03242237 0,03386398 ! antigen processing and presentation GO:0019882 117 78 0,000 0,03242237 0,03384951 ! fertilization GO:0009566 99 78 0,000 0,03242237 0,03383505 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,03242237 0,0338206 ! blood coagulation GO:0007596 151 79 0,000 0,0328316 0,03423286 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,0328316 0,03421825 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,0328316 0,03420366 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,0328316 0,03418908 ! protein oligomerization GO:0051259 149 79 0,000 0,0328316 0,03417452 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,0328316 0,03415996 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,03324066 0,03457085 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,03324066 0,03455614 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,03324066 0,03454144 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,03324066 0,03452676 ! meiosis GO:0007126 143 81 0,000 0,03364957 0,03493663 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 0,000 0,03364957 0,03492179 ! response to hypoxia GO:0001666 178 81 0,000 0,03364957 0,03490696 ! positive regulation of phosphorylation GO:0042327 149 81 0,000 0,03364957 0,03489214 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,03364957 0,03487734 ! regulation of peptidase activity GO:0052547 150 82 0,000 0,03405831 0,03528603 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,03405831 0,03527107 ! protein import into nucleus GO:0006606 174 82 0,000 0,03405831 0,03525612 ! meiotic cell cycle GO:0051321 144 82 0,000 0,03405831 0,03524119 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,03446689 0,03564886 ! exocytosis GO:0006887 153 83 0,000 0,03446689 0,03563378 ! response to drug GO:0042493 149 83 0,000 0,03446689 0,0356187 ! response to oxygen levels GO:0070482 183 83 0,000 0,03446689 0,03560364 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,03446689 0,03558859 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 0,000 0,03446689 0,03557356 GO:0045937|positive regulation of phosphate metabolic process, ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,03446689 0,03555854 ! nuclear import GO:0051170 177 83 0,000 0,03446689 0,03554353 ! inorganic anion transport GO:0015698 156 83 0,000 0,03446689 0,03552853 ! response to metal ion GO:0010038 158 84 0,000 0,03487531 0,03593437 ! T cell activation GO:0042110 189 84 0,000 0,03487531 0,03591922 ! response to nutrient GO:0007584 135 84 0,000 0,03487531 0,03590408 ! digestion GO:0007586 130 84 0,000 0,03487531 0,03588896 ! hemostasis GO:0007599 165 85 0,000 0,03528357 0,03629379 ! negative regulation of transport GO:0051051 164 85 0,000 0,03528357 0,03627852 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,03528357 0,03626326 ! negative regulation of growth GO:0045926 168 85 0,000 0,03528357 0,03624801 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,03528357 0,03623277 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,03528357 0,03621755 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,03528357 0,03620234 ! cellular response to hormone stimulus GO:0032870 182 85 0,000 0,03528357 0,03618714 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,03569167 0,03659033 ! regulation of lyase activity GO:0051339 169 86 0,000 0,03569167 0,03657498 ! positive regulation of cell activation GO:0050867 161 86 0,000 0,03569167 0,03655964 GO:0002696|positive regulation of leukocyte activation, ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,0360996 0,036962 ! mitochondrion organization GO:0007005 159 87 0,000 0,0360996 0,03694652 ! alcohol catabolic process GO:0046164 142 87 0,000 0,0360996 0,03693104 ! nucleosome assembly GO:0006334 126 87 0,000 0,0360996 0,03691559 ! regulation of protein transport GO:0051223 165 87 0,000 0,0360996 0,03690014 GO:0070201|regulation of establishment of protein localization, ! cellular respiration GO:0045333 143 88 0,000 0,03650738 0,03730135 ! amine biosynthetic process GO:0009309 146 88 0,000 0,03650738 0,03728576 ! sensory perception of smell GO:0007608 117 88 0,000 0,03650738 0,03727018 ! chromatin assembly GO:0031497 128 88 0,000 0,03650738 0,03725461 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,03650738 0,03723905 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,036915 0,03763912 ! regulation of DNA binding GO:0051101 167 89 0,000 0,036915 0,03762342 ! tube morphogenesis GO:0035239 194 89 0,000 0,036915 0,03760773 ! cellular defense response GO:0006968 123 89 0,000 0,036915 0,03759205 ! protein localization in nucleus GO:0034504 192 89 0,000 0,036915 0,03757639 ! regulation of neurological system process GO:0031644 175 89 0,000 0,036915 0,03756074 ! response to inorganic substance GO:0010035 173 90 0,000 0,03732245 0,03795951 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,03732245 0,03794371 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,03732245 0,03792793 ! response to unfolded protein GO:0006986 139 90 0,000 0,03732245 0,03791216 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,03732245 0,0378964 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,03772974 0,03829404 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,03772974 0,03827814 ! gland development GO:0048732 220 91 0,000 0,03772974 0,03826225 ! defense response to bacterium GO:0042742 112 91 0,000 0,03772974 0,03824637 ! bone development GO:0060348 206 92 0,000 0,03813687 0,03864305 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,03813687 0,03862702 ! regulation of cell adhesion GO:0030155 241 92 0,000 0,03813687 0,03861102 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,03854385 0,03900688 ! amine transport GO:0015837 181 93 0,000 0,03854385 0,03899073 ! positive regulation of MAP kinase activity GO:0043406 174 93 0,000 0,03854385 0,03897459 ! vitamin metabolic process GO:0006766 153 93 0,000 0,03854385 0,03895847 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,03895066 0,03935337 ! female pregnancy GO:0007565 166 94 0,000 0,03895066 0,0393371 ! sterol metabolic process GO:0016125 166 94 0,000 0,03895066 0,03932085 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,03895066 0,03930461 ! regulation of membrane potential GO:0042391 179 94 0,000 0,03895066 0,03928838 ! regulation of defense response GO:0031347 171 95 0,000 0,03935731 0,03968217 ! nucleosome organization GO:0034728 143 95 0,000 0,03935731 0,0396658 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,03935731 0,03964944 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,03935731 0,0396331 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,03935731 0,03961677 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,03935731 0,03960045 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,03935731 0,03958415 ! sex differentiation GO:0007548 171 96 0,000 0,0397638 0,03997652 ! response to protein stimulus GO:0051789 158 96 0,000 0,0397638 0,03996008 ! regulation of T cell activation GO:0050863 175 96 0,000 0,0397638 0,03994365 ! regulation of DNA metabolic process GO:0051052 188 97 0,000 0,04017012 0,04033523 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,04017012 0,04031866 ! transcription initiation GO:0006352 171 97 0,000 0,04017012 0,0403021 ! regulation of protein localization GO:0032880 188 97 0,000 0,04017012 0,04028556 ! leukocyte differentiation GO:0002521 232 98 0,000 0,04057629 0,04067619 ! forebrain development GO:0030900 210 98 0,000 0,04057629 0,04065951 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,04057629 0,04064284 ! skeletal muscle tissue development GO:0007519 223 100 0,000 0,04138815 0,04143904 GO:0060538|skeletal muscle organ development, ! mRNA transport GO:0051028 185 100 0,000 0,04138815 0,04142206 ! positive regulation of immune response GO:0050778 175 100 0,000 0,04138815 0,0414051 ! hormone metabolic process GO:0042445 171 100 0,000 0,04138815 0,04138815