pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-b1/out-0.05-06-0.01-300-run-b1//th1-pval-1e-01-08-th2-pval-1e-02-02-th3-pval-1e-01-01-run-b1/go_data/2932-3-real-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 3,264E-07 7,506E-04 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 4,342E-07 4,994E-04 ! response to UV GO:0009411 75 46 2,000 3,689E-06 2,828E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 6,469E-06 3,72E-03 ! ER overload response GO:0006983 7 6 1,000 6,469E-06 2,976E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 9,053E-06 3,47E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,207E-05 3,965E-03 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 1,376E-05 3,955E-03 ! UV protection GO:0009650 14 10 1,000 1,938E-05 4,952E-03 ! response to light stimulus GO:0009416 153 96 2,000 3,406E-05 7,834E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 4,513E-05 9,436E-03 ! cellular response to unfolded protein GO:0034620 19 16 1,000 5,156E-05 9,882E-03 GO:0030968|endoplasmic reticulum unfolded protein response, ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 5,156E-05 9,121E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 5,841E-05 9,596E-03 ! peptidyl-serine modification GO:0018209 27 17 1,000 5,841E-05 8,956E-03 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 7,338E-05 0,01054883 ! fat cell differentiation GO:0045444 37 24 1,000 1,182E-04 0,01599411 ! base-excision repair GO:0006284 31 24 1,000 1,182E-04 0,01510555 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 2,538E-04 0,03072141 ! glycogen metabolic process GO:0005977 48 35 1,000 2,538E-04 0,02918534 ! glucan metabolic process GO:0044042 49 36 1,000 2,686E-04 0,02941937 GO:0006073|cellular glucan metabolic process, ! response to calcium ion GO:0051592 58 40 1,000 3,321E-04 0,03471535 ! double-strand break repair GO:0006302 67 40 1,000 3,321E-04 0,03320599 ! positive regulation of protein transport GO:0051222 55 40 1,000 3,321E-04 0,0318224 ! energy reserve metabolic process GO:0006112 59 41 1,000 3,49E-04 0,0321039 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 3,663E-04 0,03240024 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 3,84E-04 0,03270971 ! positive regulation of cell cycle GO:0045787 77 45 1,000 4,207E-04 0,03455402 ! regulation of translational initiation GO:0006446 64 45 1,000 4,207E-04 0,03336251 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 4,787E-04 0,03670392 ! regulation of DNA replication GO:0006275 75 48 1,000 4,787E-04 0,03551992 ! regulation of intracellular transport GO:0032386 78 49 1,000 4,989E-04 0,0358605 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 5,405E-04 0,03767246 ! nucleotide-excision repair GO:0006289 64 52 1,000 5,619E-04 0,03801252 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 7,728E-04 0,05078723 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 7,983E-04 0,0510029 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 8,504E-04 0,05286441 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 8,771E-04 0,05308707 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 8,771E-04 0,05172586 ! positive regulation of ligase activity GO:0051351 99 69 1,000 9,877E-04 0,05679558 ! response to metal ion GO:0010038 103 70 1,000 1,016E-03 0,0570183 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 1,016E-03 0,05566072 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 1,045E-03 0,05592079 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 1,075E-03 0,05618985 GO:0045937|positive regulation of phosphate metabolic process, ! response to inorganic substance GO:0010035 115 75 1,000 1,166E-03 0,0595804 ! regulation of ligase activity GO:0051340 114 75 1,000 1,166E-03 0,05828517 ! response to unfolded protein GO:0006986 99 76 1,000 1,197E-03 0,05856448 ! regulation of protein transport GO:0051223 114 76 1,000 1,197E-03 0,05734439 GO:0070201|regulation of establishment of protein localization, ! positive regulation of protein modification process GO:0031401 107 78 1,000 1,26E-03 0,05914464 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 1,325E-03 0,06094555 GO:0010498|proteasomal protein catabolic process, ! response to protein stimulus GO:0051789 111 81 1,000 1,358E-03 0,06123985 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 1,494E-03 0,06607875 ! regulation of protein localization GO:0032880 132 85 1,000 1,494E-03 0,06483198 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 1,529E-03 0,06512158 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 1,564E-03 0,06541702 ! interphase GO:0051325 159 88 1,000 1,6E-03 0,06571795 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 1,785E-03 0,07201751 ! polysaccharide metabolic process GO:0005976 129 93 1,000 1,785E-03 0,07077583 ! regulation of translation GO:0006417 151 100 1,000 2,06E-03 0,08029089 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 3,428E-03 0,13139841 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 3,428E-03 0,12924434 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 3,428E-03 0,12715976 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 3,428E-03 0,12514135 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 3,428E-03 0,12318601 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 3,428E-03 0,12129084 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 3,428E-03 0,1194531 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 3,428E-03 0,11767022 ! sleep GO:0030431 11 5 0,000 3,428E-03 0,11593978 ! negative regulation of bone resorption GO:0045779 10 5 0,000 3,428E-03 0,11425949 ! nucleotide-sugar transport GO:0015780 8 5 0,000 3,428E-03 0,11262721 ! regulation of interferon-beta production GO:0032648 5 5 0,000 3,428E-03 0,11104091 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 3,428E-03 0,10949868 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 3,428E-03 0,1079987 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 3,428E-03 0,10653926 ! tongue development GO:0043586 6 5 0,000 3,428E-03 0,10511873 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 3,428E-03 0,10373559 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 3,428E-03 0,10238838 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 3,428E-03 0,1010757 ! cobalt ion transport GO:0006824 9 5 0,000 3,428E-03 0,09979626 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 3,428E-03 0,09854881 ! SMAD protein complex assembly GO:0007183 9 5 0,000 3,428E-03 0,09733216 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 3,428E-03 0,09614518 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 3,428E-03 0,09498681 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 3,428E-03 0,09385601 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 3,428E-03 0,09275182 ! embryonic camera-type eye development GO:0031076 8 5 0,000 3,428E-03 0,09167331 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 3,428E-03 0,0906196 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 3,428E-03 0,08958983 ! adaptation of signaling pathway GO:0022401 7 5 0,000 3,428E-03 0,0885832 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 3,428E-03 0,08759894 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 3,428E-03 0,08663632 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 3,428E-03 0,08569462 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 3,428E-03 0,08477317 ! positive regulation of histone modification GO:0031058 5 5 0,000 3,428E-03 0,08387133 ! malate metabolic process GO:0006108 7 5 0,000 3,428E-03 0,08298847 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 3,428E-03 0,08212401 ! behavioral response to pain GO:0048266 7 5 0,000 3,428E-03 0,08127737 ! clathrin coat assembly GO:0048268 11 5 0,000 3,428E-03 0,08044801 ! phototransduction, visible light GO:0007603 6 5 0,000 3,428E-03 0,0796354 ! regulation of dopamine uptake GO:0051584 9 5 0,000 3,428E-03 0,07883905 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 3,428E-03 0,07805846 ! mating behavior GO:0007617 6 5 0,000 3,428E-03 0,07729319 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 3,428E-03 0,07654277 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 3,428E-03 0,07580678 ! rhythmic behavior GO:0007622 12 5 0,000 3,428E-03 0,07508481 ! copulation GO:0007620 7 5 0,000 3,428E-03 0,07437646 ! glial cell fate commitment GO:0021781 12 5 0,000 3,428E-03 0,07368135 ! protein maturation by protein folding GO:0022417 12 5 0,000 3,428E-03 0,07299912 ! embryonic hemopoiesis GO:0035162 10 5 0,000 3,428E-03 0,0723294 ! regulation of potassium ion transport GO:0043266 9 5 0,000 3,428E-03 0,07167186 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 3,428E-03 0,07102617 ! apoptotic cell clearance GO:0043277 13 5 0,000 3,428E-03 0,07039201 ! lipoprotein particle clearance GO:0034381 9 5 0,000 3,428E-03 0,06976907 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 3,428E-03 0,06915706 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 3,428E-03 0,06855569 ! response to protozoan GO:0001562 9 5 0,000 3,428E-03 0,0679647 ! positive regulation of glycolysis GO:0045821 11 5 0,000 3,428E-03 0,0673838 ! lymph vessel development GO:0001945 7 5 0,000 3,428E-03 0,06681275 ! endochondral ossification GO:0001958 12 5 0,000 3,428E-03 0,0662513 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 3,428E-03 0,06569921 ! parathyroid gland development GO:0060017 8 5 0,000 3,428E-03 0,06515624 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 3,428E-03 0,06462217 ! anagen GO:0042640 6 5 0,000 3,428E-03 0,06409679 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 3,428E-03 0,06357988 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 3,428E-03 0,06307124 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 3,428E-03 0,06257067 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 3,428E-03 0,06207799 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 3,428E-03 0,06159301 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 3,428E-03 0,06111554 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 3,428E-03 0,06064542 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 3,428E-03 0,06018248 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 3,428E-03 0,05972655 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 3,428E-03 0,05927748 ! cardiac muscle fiber development GO:0048739 7 5 0,000 3,428E-03 0,05883511 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 3,428E-03 0,0583993 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 3,428E-03 0,05796989 ! neutrophil mediated immunity GO:0002446 6 5 0,000 3,428E-03 0,05754675 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 3,428E-03 0,05712975 ! ovulation GO:0030728 6 5 0,000 3,428E-03 0,05671874 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 3,428E-03 0,05631361 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 3,428E-03 0,05591422 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 3,428E-03 0,05552046 ! response to pH GO:0009268 9 5 0,000 3,428E-03 0,0551322 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 3,428E-03 0,05474934 ! proline biosynthetic process GO:0006561 6 5 0,000 3,428E-03 0,05437176 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 3,428E-03 0,05399935 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 3,428E-03 0,05363201 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 3,428E-03 0,05326963 ! polyol catabolic process GO:0046174 7 5 0,000 3,428E-03 0,05291211 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 3,428E-03 0,05255937 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 3,428E-03 0,05221129 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 3,428E-03 0,0518678 ! sister chromatid cohesion GO:0007062 9 5 0,000 3,428E-03 0,05152879 ! nerve growth factor processing GO:0032455 7 5 0,000 3,428E-03 0,05119419 ! urea metabolic process GO:0019627 6 5 0,000 3,428E-03 0,0508639 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 3,428E-03 0,05053785 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 3,428E-03 0,05021595 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 3,428E-03 0,04989813 ! neutrophil activation GO:0042119 5 5 0,000 3,428E-03 0,04958431 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 3,428E-03 0,04927441 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 3,428E-03 0,04896835 ! response to food GO:0032094 5 5 0,000 3,428E-03 0,04866608 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 3,428E-03 0,04836751 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 3,428E-03 0,04807259 ! paraxial mesoderm development GO:0048339 9 5 0,000 3,428E-03 0,04778124 ! forebrain neuron development GO:0021884 7 5 0,000 3,428E-03 0,0474934 ! melanosome organization GO:0032438 7 5 0,000 3,428E-03 0,04720901 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 3,428E-03 0,04692801 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 3,428E-03 0,04665032 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 3,428E-03 0,04637591 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 3,428E-03 0,04610471 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 3,428E-03 0,04583666 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 3,428E-03 0,0455717 ! nucleoside transport GO:0015858 6 5 0,000 3,428E-03 0,0453098 ! nucleoside salvage GO:0043174 7 5 0,000 3,428E-03 0,04505089 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 3,428E-03 0,04479491 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 3,428E-03 0,04454184 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 3,428E-03 0,0442916 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 3,428E-03 0,04404416 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 3,428E-03 0,04379947 ! early endosome to late endosome transport GO:0045022 11 5 0,000 3,428E-03 0,04355749 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 3,428E-03 0,04331816 ! depyrimidination GO:0045008 8 5 0,000 3,428E-03 0,04308145 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 3,428E-03 0,04284731 ! 5S class rRNA transcription GO:0042791 8 5 0,000 3,428E-03 0,0426157 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 3,428E-03 0,04238659 ! regulation of centrosome cycle GO:0046605 7 5 0,000 3,428E-03 0,04215992 ! neuronal ion channel clustering GO:0045161 7 5 0,000 3,428E-03 0,04193566 ! sodium ion homeostasis GO:0055078 6 5 0,000 3,428E-03 0,04171378 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 3,428E-03 0,04149424 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 3,428E-03 0,04127699 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 3,428E-03 0,041062 ! monocyte differentiation GO:0030224 8 5 0,000 3,428E-03 0,04084925 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 3,428E-03 0,04063868 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 3,428E-03 0,04043028 ! centrosome duplication GO:0051298 5 5 0,000 3,428E-03 0,040224 ! response to UV-C GO:0010225 6 5 0,000 3,428E-03 0,04001982 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 3,428E-03 0,0398177 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 3,428E-03 0,03961761 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 3,428E-03 0,03941952 ! regulation of dendrite development GO:0050773 12 5 0,000 3,428E-03 0,03922341 ! peptidyl-arginine modification GO:0018195 7 5 0,000 3,428E-03 0,03902923 ! positive regulation of organ growth GO:0046622 6 5 0,000 3,428E-03 0,03883697 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 3,428E-03 0,03864659 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 3,428E-03 0,03845807 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 3,428E-03 0,03827138 ! regulation of dopamine secretion GO:0014059 12 5 0,000 3,428E-03 0,0380865 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 3,428E-03 0,03790339 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 3,428E-03 0,03772203 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 3,428E-03 0,0375424 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 3,428E-03 0,03736448 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 3,428E-03 0,03718823 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 3,428E-03 0,03701364 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 3,428E-03 0,03684068 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 3,428E-03 0,03666933 ! neural tube patterning GO:0021532 6 5 0,000 3,428E-03 0,03649956 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 3,428E-03 0,03633136 ! histone demethylation GO:0016577 9 5 0,000 3,428E-03 0,0361647 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 3,428E-03 0,03599957 ! regulation of sterol transport GO:0032371 7 5 0,000 3,428E-03 0,03583593 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 3,428E-03 0,03567378 ! enteric nervous system development GO:0048484 8 5 0,000 3,428E-03 0,03551309 ! establishment of planar polarity GO:0001736 6 5 0,000 3,428E-03 0,03535383 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 3,428E-03 0,035196 ! muscle cell proliferation GO:0033002 8 5 0,000 3,428E-03 0,03503958 ! transcription termination GO:0006353 8 5 0,000 3,428E-03 0,03488453 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 3,428E-03 0,03473086 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 3,428E-03 0,03457853 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 3,428E-03 0,03442753 ! regulation of respiratory burst GO:0060263 8 5 0,000 3,428E-03 0,03427785 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 3,428E-03 0,03412946 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 3,428E-03 0,03398235 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 3,428E-03 0,0338365 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 3,428E-03 0,0336919 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 3,428E-03 0,03354853 ! apical protein localization GO:0045176 6 5 0,000 3,428E-03 0,03340638 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 3,428E-03 0,03326542 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 3,428E-03 0,03312565 ! galactolipid metabolic process GO:0019374 7 5 0,000 3,428E-03 0,03298705 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 3,428E-03 0,0328496 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 3,428E-03 0,0327133 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 3,428E-03 0,03257812 ! triglyceride catabolic process GO:0019433 6 5 0,000 3,428E-03 0,03244405 ! glial cell migration GO:0008347 10 5 0,000 3,428E-03 0,03231109 ! determination of adult lifespan GO:0008340 8 5 0,000 3,428E-03 0,0321792 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 3,428E-03 0,03204839 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 3,428E-03 0,03191864 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 3,428E-03 0,03178994 ! somatic stem cell maintenance GO:0035019 13 5 0,000 3,428E-03 0,03166227 ! cerebellar cortex formation GO:0021697 6 5 0,000 3,428E-03 0,03153562 ! neural plate development GO:0001840 6 5 0,000 3,428E-03 0,03140998 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 3,428E-03 0,03128534 ! regulation of sensory perception GO:0051931 6 5 0,000 3,428E-03 0,03116168 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 3,428E-03 0,031039 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 3,428E-03 0,03091727 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 3,428E-03 0,0307965 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 3,428E-03 0,03067667 ! sensory cilium assembly GO:0035058 6 5 0,000 3,428E-03 0,03055777 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 3,428E-03 0,03043979 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 3,428E-03 0,03032271 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 3,428E-03 0,03020653 ! spindle assembly GO:0051225 5 5 0,000 3,428E-03 0,03009124 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 3,428E-03 0,02997682 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 3,428E-03 0,02986328 ! protein amino acid prenylation GO:0018346 9 5 0,000 3,428E-03 0,02975058 ! organ regeneration GO:0031100 7 5 0,000 3,428E-03 0,02963874 ! NAD biosynthetic process GO:0009435 7 5 0,000 3,428E-03 0,02952773 ! carnitine metabolic process GO:0009437 5 5 0,000 3,428E-03 0,02941756 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 3,428E-03 0,0293082 ! cellular anion homeostasis GO:0030002 6 5 0,000 3,428E-03 0,02919965 GO:0055081|anion homeostasis, ! tRNA transcription GO:0009304 11 6 0,000 4,112E-03 0,0348993 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 4,112E-03 0,03477099 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 4,112E-03 0,03464363 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 4,112E-03 0,03451719 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 4,112E-03 0,03439167 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 4,112E-03 0,03426707 ! regulation of helicase activity GO:0051095 11 6 0,000 4,112E-03 0,03414336 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 4,112E-03 0,03402054 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 4,112E-03 0,0338986 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 4,112E-03 0,03377754 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 4,112E-03 0,03365733 ! positive regulation of axon extension GO:0045773 8 6 0,000 4,112E-03 0,03353798 ! prostate gland development GO:0030850 9 6 0,000 4,112E-03 0,03341947 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 4,112E-03 0,0333018 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 4,112E-03 0,03318495 ! forebrain neuron differentiation GO:0021879 9 6 0,000 4,112E-03 0,03306892 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 4,112E-03 0,03295369 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 4,112E-03 0,03283927 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 4,112E-03 0,03272564 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 4,112E-03 0,03261279 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 4,112E-03 0,03250072 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 4,112E-03 0,03238942 ! neuron adhesion GO:0007158 9 6 0,000 4,112E-03 0,03227887 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 4,112E-03 0,03216908 ! establishment of tissue polarity GO:0007164 7 6 0,000 4,112E-03 0,03206003 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 4,112E-03 0,03195172 ! signal peptide processing GO:0006465 8 6 0,000 4,112E-03 0,03184414 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 4,112E-03 0,03173728 ! mRNA stabilization GO:0048255 15 6 0,000 4,112E-03 0,03163114 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 4,112E-03 0,0315257 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 4,112E-03 0,03142096 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 4,112E-03 0,03131692 ! opsonization GO:0008228 8 6 0,000 4,112E-03 0,03121356 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 4,112E-03 0,03111089 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 4,112E-03 0,03100889 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 4,112E-03 0,03090755 ! protein amino acid dealkylation GO:0008214 11 6 0,000 4,112E-03 0,03080687 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 4,112E-03 0,03070685 ! photoreceptor cell development GO:0042461 10 6 0,000 4,112E-03 0,03060748 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 4,112E-03 0,03050874 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 4,112E-03 0,03041064 ! mechanosensory behavior GO:0007638 8 6 0,000 4,112E-03 0,03031317 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 4,112E-03 0,03021633 ! negative regulation of endocytosis GO:0045806 8 6 0,000 4,112E-03 0,0301201 ! response to interferon-gamma GO:0034341 12 6 0,000 4,112E-03 0,03002448 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 4,112E-03 0,02992946 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 4,112E-03 0,02983505 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 4,112E-03 0,02974123 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 4,112E-03 0,02964799 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 4,112E-03 0,02955534 ! cGMP-mediated signaling GO:0019934 10 6 0,000 4,112E-03 0,02946327 ! activation of MAPKKK activity GO:0000185 10 6 0,000 4,112E-03 0,02937177 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 4,112E-03 0,02928084 ! thymic T cell selection GO:0045061 12 6 0,000 4,112E-03 0,02919046 ! protein lipoylation GO:0009249 10 6 0,000 4,112E-03 0,02910065 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 4,112E-03 0,02901138 ! pigment granule organization GO:0048753 11 6 0,000 4,112E-03 0,02892266 ! drug transport GO:0015893 6 6 0,000 4,112E-03 0,02883448 ! cysteine metabolic process GO:0006534 7 6 0,000 4,112E-03 0,02874684 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 4,112E-03 0,02865973 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 4,112E-03 0,02857314 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 4,112E-03 0,02848708 ! histidine metabolic process GO:0006547 6 6 0,000 4,112E-03 0,02840153 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 4,112E-03 0,0283165 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 4,112E-03 0,02823197 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 4,112E-03 0,02814795 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 4,112E-03 0,02806442 ! adenohypophysis development GO:0021984 10 6 0,000 4,112E-03 0,02798139 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 4,112E-03 0,02789885 ! hyperosmotic response GO:0006972 8 6 0,000 4,112E-03 0,02781679 ! microtubule nucleation GO:0007020 10 6 0,000 4,112E-03 0,02773522 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 4,112E-03 0,02765412 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 4,112E-03 0,0275735 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 4,112E-03 0,02749334 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 4,112E-03 0,02741365 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 4,112E-03 0,02733442 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 4,112E-03 0,02725565 ! response to dietary excess GO:0002021 7 6 0,000 4,112E-03 0,02717733 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 4,112E-03 0,02709946 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 4,112E-03 0,02702203 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 4,112E-03 0,02694504 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 4,112E-03 0,02686849 ! glycerol ether catabolic process GO:0044269 8 6 0,000 4,112E-03 0,02679238 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 4,112E-03 0,0267167 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 4,112E-03 0,02664144 ! neuron apoptosis GO:0051402 8 6 0,000 4,112E-03 0,0265666 ! organic alcohol transport GO:0015850 9 6 0,000 4,112E-03 0,02649219 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 4,112E-03 0,02641818 ! T cell mediated immunity GO:0002456 12 6 0,000 4,112E-03 0,0263446 ! male sex determination GO:0030238 9 6 0,000 4,112E-03 0,02627142 ! carnitine transport GO:0015879 8 6 0,000 4,112E-03 0,02619864 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 4,112E-03 0,02612627 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 4,112E-03 0,0260543 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 4,112E-03 0,02598272 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 4,112E-03 0,02591153 ! positive regulation of exocytosis GO:0045921 6 6 0,000 4,112E-03 0,02584074 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 4,112E-03 0,02577033 ! parturition GO:0007567 12 6 0,000 4,112E-03 0,0257003 ! negative regulation of translational initiation GO:0045947 7 6 0,000 4,112E-03 0,02563065 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 4,112E-03 0,02556138 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 4,112E-03 0,02549248 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 4,112E-03 0,02542395 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 4,112E-03 0,02535579 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 4,112E-03 0,02528799 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 4,112E-03 0,02522056 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 4,112E-03 0,02515348 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 4,112E-03 0,02508676 ! macrophage differentiation GO:0030225 10 6 0,000 4,112E-03 0,0250204 ! astrocyte development GO:0014002 14 6 0,000 4,112E-03 0,02495438 ! hyaluronan metabolic process GO:0030212 6 6 0,000 4,112E-03 0,02488871 ! purine base biosynthetic process GO:0009113 14 6 0,000 4,112E-03 0,02482339 ! interaction with symbiont GO:0051702 8 6 0,000 4,112E-03 0,0247584 ! anterograde axon cargo transport GO:0008089 8 6 0,000 4,112E-03 0,02469376 ! skeletal muscle contraction GO:0003009 6 6 0,000 4,112E-03 0,02462945 ! eating behavior GO:0042755 6 6 0,000 4,112E-03 0,02456548 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 4,112E-03 0,02450184 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 4,112E-03 0,02443853 ! response to copper ion GO:0046688 9 6 0,000 4,112E-03 0,02437554 ! DNA topological change GO:0006265 8 6 0,000 4,112E-03 0,02431288 ! response to exogenous dsRNA GO:0043330 8 6 0,000 4,112E-03 0,02425054 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 4,112E-03 0,02418852 ! establishment of melanosome localization GO:0032401 9 6 0,000 4,112E-03 0,02412681 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 4,112E-03 0,02406542 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 4,112E-03 0,02400434 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 4,112E-03 0,02394357 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 4,112E-03 0,02388311 ! nucleoside catabolic process GO:0009164 6 6 0,000 4,112E-03 0,02382295 ! gas homeostasis GO:0033483 11 6 0,000 4,112E-03 0,02376309 ! hair follicle maturation GO:0048820 7 6 0,000 4,112E-03 0,02370353 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 4,112E-03 0,02364428 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 4,112E-03 0,02358531 ! Schwann cell development GO:0014044 14 6 0,000 4,112E-03 0,02352664 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 4,112E-03 0,02346826 ! dendrite morphogenesis GO:0048813 9 6 0,000 4,112E-03 0,02341017 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 4,112E-03 0,02335237 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 4,112E-03 0,02329485 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 4,112E-03 0,02323762 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 4,112E-03 0,02318066 ! histone ubiquitination GO:0016574 7 6 0,000 4,112E-03 0,02312399 ! regulation of meiosis GO:0040020 10 6 0,000 4,112E-03 0,02306759 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 4,112E-03 0,02301146 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 4,112E-03 0,02295561 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 4,112E-03 0,02290002 ! regulation of mast cell activation GO:0033003 6 6 0,000 4,112E-03 0,02284471 ! membrane to membrane docking GO:0022614 12 6 0,000 4,112E-03 0,02278966 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 4,112E-03 0,02273488 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 4,112E-03 0,02268036 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 4,112E-03 0,0226261 ! receptor internalization GO:0031623 9 6 0,000 4,112E-03 0,0225721 ! neutrophil homeostasis GO:0001780 6 6 0,000 4,112E-03 0,02251836 ! coenzyme A metabolic process GO:0015936 9 6 0,000 4,112E-03 0,02246487 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 4,112E-03 0,02241164 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 4,112E-03 0,02235865 ! protein deubiquitination GO:0016579 8 6 0,000 4,112E-03 0,02230592 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 4,112E-03 0,02225344 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 4,112E-03 0,0222012 ! peptidyl-histidine modification GO:0018202 9 6 0,000 4,112E-03 0,0221492 ! axonal fasciculation GO:0007413 9 6 0,000 4,112E-03 0,02209745 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 4,112E-03 0,02204594 ! thiamin metabolic process GO:0006772 6 6 0,000 4,112E-03 0,02199467 ! midbrain development GO:0030901 6 6 0,000 4,112E-03 0,02194364 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 4,112E-03 0,02189285 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 4,112E-03 0,02184229 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 4,112E-03 0,02179196 ! progesterone metabolic process GO:0042448 8 6 0,000 4,112E-03 0,02174186 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 4,112E-03 0,021692 ! glycolipid catabolic process GO:0019377 13 6 0,000 4,112E-03 0,02164236 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 4,112E-03 0,02159295 ! positive regulation of glucose import GO:0046326 6 6 0,000 4,112E-03 0,02154376 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 4,112E-03 0,0214948 ! adult feeding behavior GO:0008343 6 6 0,000 4,112E-03 0,02144605 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 4,112E-03 0,02139753 ! blastocyst growth GO:0001832 15 6 0,000 4,112E-03 0,02134923 ! pigment granule transport GO:0051904 12 6 0,000 4,112E-03 0,02130115 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 4,112E-03 0,02125328 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 4,112E-03 0,02120563 ! catecholamine transport GO:0051937 7 6 0,000 4,112E-03 0,02115819 ! organ or tissue specific immune response GO:0002251 7 6 0,000 4,112E-03 0,02111096 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 4,112E-03 0,02106394 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 4,112E-03 0,02101713 ! negative regulation of B cell activation GO:0050869 9 6 0,000 4,112E-03 0,02097053 ! protein prenylation GO:0018342 10 6 0,000 4,112E-03 0,02092414 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 4,112E-03 0,02087795 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 4,112E-03 0,02083196 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 4,112E-03 0,02078618 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 4,112E-03 0,02074059 ! positive regulation of coagulation GO:0050820 11 6 0,000 4,112E-03 0,02069521 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 4,796E-03 0,02408411 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 4,796E-03 0,02403164 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 4,796E-03 0,0239794 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 4,796E-03 0,02392739 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 4,796E-03 0,02387559 ! synaptonemal complex assembly GO:0007130 10 7 0,000 4,796E-03 0,02382403 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 4,796E-03 0,02377268 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 4,796E-03 0,02372156 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 4,796E-03 0,02367065 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 4,796E-03 0,02361997 ! reproductive behavior GO:0019098 12 7 0,000 4,796E-03 0,0235695 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 4,796E-03 0,02351924 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 4,796E-03 0,0234692 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 4,796E-03 0,02341937 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 4,796E-03 0,02336976 ! oligopeptide transport GO:0006857 11 7 0,000 4,796E-03 0,02332035 ! protein amino acid sulfation GO:0006477 9 7 0,000 4,796E-03 0,02327115 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 4,796E-03 0,02322216 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 4,796E-03 0,02317337 ! RNA methylation GO:0001510 11 7 0,000 4,796E-03 0,02312479 ! pericardium development GO:0060039 8 7 0,000 4,796E-03 0,02307641 ! macrophage chemotaxis GO:0048246 10 7 0,000 4,796E-03 0,02302824 ! fibril organization GO:0043206 13 7 0,000 4,796E-03 0,02298026 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 4,796E-03 0,02293248 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 4,796E-03 0,02288491 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 4,796E-03 0,02283753 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 4,796E-03 0,02279034 ! lipoprotein transport GO:0042953 9 7 0,000 4,796E-03 0,02274335 ! cerebral cortex cell migration GO:0021795 11 7 0,000 4,796E-03 0,02269655 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 4,796E-03 0,02264995 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 4,796E-03 0,02260353 ! estrogen metabolic process GO:0008210 14 7 0,000 4,796E-03 0,02255731 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 4,796E-03 0,02251127 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 4,796E-03 0,02246543 ! chemosensory behavior GO:0007635 9 7 0,000 4,796E-03 0,02241977 ! microtubule bundle formation GO:0001578 8 7 0,000 4,796E-03 0,02237429 ! T-helper 1 type immune response GO:0042088 11 7 0,000 4,796E-03 0,022329 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 4,796E-03 0,02228389 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 4,796E-03 0,02223896 ! leukocyte degranulation GO:0043299 10 7 0,000 4,796E-03 0,02219421 ! bile acid and bile salt transport GO:0015721 9 7 0,000 4,796E-03 0,02214965 ! reflex GO:0060004 12 7 0,000 4,796E-03 0,02210526 ! positive regulation of isotype switching GO:0045830 15 7 0,000 4,796E-03 0,02206105 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 4,796E-03 0,02201702 ! protein-cofactor linkage GO:0018065 13 7 0,000 4,796E-03 0,02197316 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 4,796E-03 0,02192947 ! glycerolipid catabolic process GO:0046503 9 7 0,000 4,796E-03 0,02188596 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 4,796E-03 0,02184262 ! spinal cord patterning GO:0021511 7 7 0,000 4,796E-03 0,02179946 ! hemoglobin metabolic process GO:0020027 10 7 0,000 4,796E-03 0,02175646 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 4,796E-03 0,02171363 ! adrenal gland development GO:0030325 17 7 0,000 4,796E-03 0,02167097 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 4,796E-03 0,02162848 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 4,796E-03 0,02158615 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 4,796E-03 0,02154399 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 4,796E-03 0,021502 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 4,796E-03 0,02146016 ! endosome organization GO:0007032 10 7 0,000 4,796E-03 0,02141849 ! thyroid hormone generation GO:0006590 11 7 0,000 4,796E-03 0,02137699 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 4,796E-03 0,02133564 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 4,796E-03 0,02129445 ! regulation of pigmentation during development GO:0048070 15 7 0,000 4,796E-03 0,02125342 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 4,796E-03 0,02121255 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 4,796E-03 0,02117183 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 4,796E-03 0,02113127 ! galactose metabolic process GO:0006012 10 7 0,000 4,796E-03 0,02109087 ! vesicle fusion GO:0006906 15 7 0,000 4,796E-03 0,02105062 ! intracellular pH reduction GO:0051452 10 7 0,000 4,796E-03 0,02101052 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 4,796E-03 0,02097058 ! organ growth GO:0035265 11 7 0,000 4,796E-03 0,02093079 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 4,796E-03 0,02089115 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 4,796E-03 0,02085165 ! Rac protein signal transduction GO:0016601 7 7 0,000 4,796E-03 0,02081231 ! retinol metabolic process GO:0042572 9 7 0,000 4,796E-03 0,02077312 ! behavioral fear response GO:0001662 13 7 0,000 4,796E-03 0,02073407 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 4,796E-03 0,02069517 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 4,796E-03 0,02065641 ! rRNA modification GO:0000154 12 7 0,000 4,796E-03 0,0206178 ! protein heterooligomerization GO:0051291 10 7 0,000 4,796E-03 0,02057934 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 4,796E-03 0,02054101 ! response to UV-B GO:0010224 11 7 0,000 4,796E-03 0,02050283 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 4,796E-03 0,0204648 ! protein retention in ER lumen GO:0006621 12 7 0,000 4,796E-03 0,0204269 ! intermediate filament organization GO:0045109 11 7 0,000 4,796E-03 0,02038914 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 4,796E-03 0,02035152 ! cardiac muscle cell development GO:0055013 9 7 0,000 4,796E-03 0,02031404 ! fibrinolysis GO:0042730 9 7 0,000 4,796E-03 0,0202767 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 4,796E-03 0,02023949 ! regulation of circadian rhythm GO:0042752 11 7 0,000 4,796E-03 0,02020243 ! B cell lineage commitment GO:0002326 17 7 0,000 4,796E-03 0,02016549 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 4,796E-03 0,02012869 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 4,796E-03 0,02009203 ! response to tropane GO:0014073 13 7 0,000 4,796E-03 0,0200555 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 4,796E-03 0,0200191 ! melanosome localization GO:0032400 10 7 0,000 4,796E-03 0,01998283 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 4,796E-03 0,0199467 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 4,796E-03 0,01991069 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 4,796E-03 0,01987482 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 4,796E-03 0,01983907 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 4,796E-03 0,01980346 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 4,796E-03 0,01976797 ! mast cell activation GO:0045576 9 7 0,000 4,796E-03 0,0197326 ! multicellular organismal aging GO:0010259 11 7 0,000 4,796E-03 0,01969737 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 4,796E-03 0,01966225 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 4,796E-03 0,01962727 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 4,796E-03 0,01959241 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 4,796E-03 0,01955767 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 4,796E-03 0,01952305 ! establishment of nucleus localization GO:0040023 13 7 0,000 4,796E-03 0,01948856 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 4,796E-03 0,01945419 ! T cell lineage commitment GO:0002360 12 7 0,000 4,796E-03 0,01941994 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 4,796E-03 0,01938581 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 4,796E-03 0,0193518 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 4,796E-03 0,01931791 ! regulation of lipid transport GO:0032368 13 7 0,000 4,796E-03 0,01928413 ! response to tumor cell GO:0002347 12 7 0,000 4,796E-03 0,01925048 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 4,796E-03 0,01921694 ! neuroblast proliferation GO:0007405 13 7 0,000 4,796E-03 0,01918352 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 4,796E-03 0,01915022 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 4,796E-03 0,01911703 ! peptidyl-threonine modification GO:0018210 18 7 0,000 4,796E-03 0,01908395 ! diuresis GO:0030146 12 7 0,000 4,796E-03 0,01905099 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 4,796E-03 0,01901815 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 4,796E-03 0,01898541 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 4,796E-03 0,01895279 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 4,796E-03 0,01892028 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 4,796E-03 0,01888788 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 4,796E-03 0,0188556 ! melanin biosynthetic process GO:0042438 8 7 0,000 4,796E-03 0,01882342 ! regulation of synaptogenesis GO:0051963 10 7 0,000 4,796E-03 0,01879135 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 4,796E-03 0,0187594 ! dopamine biosynthetic process GO:0042416 15 7 0,000 4,796E-03 0,01872755 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 4,796E-03 0,0186958 ! lymph node development GO:0048535 9 7 0,000 4,796E-03 0,01866417 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 4,796E-03 0,01863264 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 4,796E-03 0,01860122 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 4,796E-03 0,01856991 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 4,796E-03 0,0185387 ! endosome to lysosome transport GO:0008333 10 7 0,000 4,796E-03 0,01850759 ! ATP catabolic process GO:0006200 10 7 0,000 4,796E-03 0,01847659 ! establishment of pigment granule localization GO:0051905 13 7 0,000 4,796E-03 0,01844569 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 4,796E-03 0,0184149 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 4,796E-03 0,01838421 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 4,796E-03 0,01835362 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 4,796E-03 0,01832313 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 4,796E-03 0,01829274 ! muscle adaptation GO:0043500 12 7 0,000 4,796E-03 0,01826246 ! amino sugar catabolic process GO:0046348 9 7 0,000 4,796E-03 0,01823227 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 4,796E-03 0,01820219 ! retina homeostasis GO:0001895 9 7 0,000 4,796E-03 0,0181722 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 4,796E-03 0,01814231 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 4,796E-03 0,01811252 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 4,796E-03 0,01808283 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 4,796E-03 0,01805323 ! behavioral response to nicotine GO:0035095 11 7 0,000 4,796E-03 0,01802373 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 4,796E-03 0,01799433 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 4,796E-03 0,01796502 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 5,479E-03 0,02049162 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 5,479E-03 0,02045836 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 5,479E-03 0,0204252 ! axon extension GO:0048675 11 8 0,000 5,479E-03 0,02039215 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 5,479E-03 0,02035921 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 5,479E-03 0,02032637 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 5,479E-03 0,02029364 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 5,479E-03 0,02026101 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 5,479E-03 0,02022849 ! cell proliferation in forebrain GO:0021846 10 8 0,000 5,479E-03 0,02019607 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 5,479E-03 0,02016376 ! phosphate transport GO:0006817 10 8 0,000 5,479E-03 0,02013155 ! N-glycan processing GO:0006491 12 8 0,000 5,479E-03 0,02009944 ! Golgi to endosome transport GO:0006895 16 8 0,000 5,479E-03 0,02006743 ! UTP metabolic process GO:0046051 8 8 0,000 5,479E-03 0,02003553 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 5,479E-03 0,02000373 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 5,479E-03 0,01997203 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 5,479E-03 0,01994043 ! neurotransmitter uptake GO:0001504 10 8 0,000 5,479E-03 0,01990892 ! succinate metabolic process GO:0006105 14 8 0,000 5,479E-03 0,01987752 ! smoothened signaling pathway GO:0007224 8 8 0,000 5,479E-03 0,01984622 ! membrane hyperpolarization GO:0060081 10 8 0,000 5,479E-03 0,01981501 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 5,479E-03 0,01978391 ! keratinocyte proliferation GO:0043616 12 8 0,000 5,479E-03 0,0197529 ! middle ear morphogenesis GO:0042474 9 8 0,000 5,479E-03 0,01972199 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 5,479E-03 0,01969117 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 5,479E-03 0,01966045 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 5,479E-03 0,01962983 ! ganglioside metabolic process GO:0001573 15 8 0,000 5,479E-03 0,0195993 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 5,479E-03 0,01956887 ! pseudouridine synthesis GO:0001522 9 8 0,000 5,479E-03 0,01953853 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 5,479E-03 0,01950828 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 5,479E-03 0,01947813 ! endothelial cell differentiation GO:0045446 14 8 0,000 5,479E-03 0,01944807 ! ceramide biosynthetic process GO:0046513 9 8 0,000 5,479E-03 0,0194181 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 5,479E-03 0,01938823 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 5,479E-03 0,01935845 ! astrocyte differentiation GO:0048708 16 8 0,000 5,479E-03 0,01932876 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 5,479E-03 0,01929916 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 5,479E-03 0,01926965 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 5,479E-03 0,01924023 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 5,479E-03 0,0192109 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 5,479E-03 0,01918166 ! melanin metabolic process GO:0006582 12 8 0,000 5,479E-03 0,01915251 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 5,479E-03 0,01912344 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 5,479E-03 0,01909447 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 5,479E-03 0,01906558 ! macrophage activation GO:0042116 12 8 0,000 5,479E-03 0,01903678 ! regulation of type I interferon production GO:0032479 8 8 0,000 5,479E-03 0,01900807 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 5,479E-03 0,01897944 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 5,479E-03 0,0189509 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 5,479E-03 0,01892245 ! regulation of vascular permeability GO:0043114 12 8 0,000 5,479E-03 0,01889408 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 5,479E-03 0,01886579 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 5,479E-03 0,01883759 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 5,479E-03 0,01880948 ! ruffle organization GO:0031529 11 8 0,000 5,479E-03 0,01878144 ! osteoblast development GO:0002076 13 8 0,000 5,479E-03 0,0187535 ! lens development in camera-type eye GO:0002088 10 8 0,000 5,479E-03 0,01872563 ! positive regulation of vasodilation GO:0045909 12 8 0,000 5,479E-03 0,01869785 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 5,479E-03 0,01867015 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 5,479E-03 0,01864253 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 5,479E-03 0,01861499 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 5,479E-03 0,01858754 ! Schwann cell differentiation GO:0014037 17 8 0,000 5,479E-03 0,01856016 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 5,479E-03 0,01853287 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 5,479E-03 0,01850565 ! regulation of gliogenesis GO:0014013 20 8 0,000 5,479E-03 0,01847852 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 5,479E-03 0,01845146 ! oligodendrocyte development GO:0014003 8 8 0,000 5,479E-03 0,01842449 ! segment specification GO:0007379 10 8 0,000 5,479E-03 0,01839759 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 5,479E-03 0,01837077 ! cellular extravasation GO:0045123 11 8 0,000 5,479E-03 0,01834403 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 5,479E-03 0,01831737 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 5,479E-03 0,01829078 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 5,479E-03 0,01826427 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 5,479E-03 0,01823784 ! snRNA metabolic process GO:0016073 10 8 0,000 5,479E-03 0,01821149 GO:0016180|snRNA processing, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 0,000 5,479E-03 0,01818521 ! regulation of interleukin-4 production GO:0032673 16 8 0,000 5,479E-03 0,018159 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 5,479E-03 0,01813288 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 5,479E-03 0,01810682 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 5,479E-03 0,01808085 ! nucleosome disassembly GO:0006337 12 8 0,000 5,479E-03 0,01805494 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 5,479E-03 0,01802911 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 5,479E-03 0,01800336 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 5,479E-03 0,01797767 ! icosanoid secretion GO:0032309 12 8 0,000 5,479E-03 0,01795206 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 5,479E-03 0,01792653 ! leukocyte activation during immune response GO:0002366 13 8 0,000 5,479E-03 0,01790106 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 5,479E-03 0,01787567 ! cerebellum morphogenesis GO:0021587 9 8 0,000 5,479E-03 0,01785035 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 5,479E-03 0,0178251 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 5,479E-03 0,01779993 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 5,479E-03 0,01777482 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 5,479E-03 0,01774979 ! sterol catabolic process GO:0016127 9 8 0,000 5,479E-03 0,01772482 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 5,479E-03 0,01769993 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 5,479E-03 0,0176751 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 5,479E-03 0,01765035 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 5,479E-03 0,01762566 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 5,479E-03 0,01760105 ! prophase GO:0051324 11 8 0,000 5,479E-03 0,0175765 ! S phase GO:0051320 8 8 0,000 5,479E-03 0,01755202 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 5,479E-03 0,01752761 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 5,479E-03 0,01750326 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 5,479E-03 0,01747899 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 5,479E-03 0,01745478 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 5,479E-03 0,01743064 ! hormone catabolic process GO:0042447 13 8 0,000 5,479E-03 0,01740656 ! quaternary ammonium group transport GO:0015697 10 8 0,000 5,479E-03 0,01738255 ! myeloid cell homeostasis GO:0002262 8 8 0,000 5,479E-03 0,01735861 ! regulation of fibrinolysis GO:0051917 13 8 0,000 5,479E-03 0,01733473 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 5,479E-03 0,01731092 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 5,479E-03 0,01728717 ! regulation of telomere maintenance GO:0032204 10 8 0,000 5,479E-03 0,01726349 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 5,479E-03 0,01723988 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 5,479E-03 0,01721632 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 5,479E-03 0,01719284 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 5,479E-03 0,01716941 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 5,479E-03 0,01714605 ! lamellipodium assembly GO:0030032 9 8 0,000 5,479E-03 0,01712276 ! regulation of embryonic development GO:0045995 16 8 0,000 5,479E-03 0,01709952 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 5,479E-03 0,01707635 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 5,479E-03 0,01705325 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 5,479E-03 0,0170302 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 6,162E-03 0,0191271 ! regulation of developmental growth GO:0048638 13 9 0,000 6,162E-03 0,01910133 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 6,162E-03 0,01907562 ! telencephalon cell migration GO:0022029 16 9 0,000 6,162E-03 0,01904998 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 6,162E-03 0,01902441 ! pentose-phosphate shunt GO:0006098 12 9 0,000 6,162E-03 0,01899891 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 6,162E-03 0,01897347 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 6,162E-03 0,01894811 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 6,162E-03 0,01892281 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 6,162E-03 0,01889758 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 6,162E-03 0,01887242 ! GTP metabolic process GO:0046039 9 9 0,000 6,162E-03 0,01884732 ! elastic fiber assembly GO:0048251 13 9 0,000 6,162E-03 0,01882229 ! social behavior GO:0035176 14 9 0,000 6,162E-03 0,01879733 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 6,162E-03 0,01877243 ! artery development GO:0060840 19 9 0,000 6,162E-03 0,0187476 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 6,162E-03 0,01872283 ! regulation of glycolysis GO:0006110 15 9 0,000 6,162E-03 0,01869813 ! response to pain GO:0048265 16 9 0,000 6,162E-03 0,0186735 ! protein complex disassembly GO:0043241 17 9 0,000 6,162E-03 0,01864893 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 6,162E-03 0,01862442 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 6,162E-03 0,01859998 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 6,162E-03 0,0185756 ! lung alveolus development GO:0048286 17 9 0,000 6,162E-03 0,01855129 ! ciliary or flagellar motility GO:0001539 10 9 0,000 6,162E-03 0,01852704 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 6,162E-03 0,01850285 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 6,162E-03 0,01847873 ! regulation of exit from mitosis GO:0007096 12 9 0,000 6,162E-03 0,01845467 ! ventral spinal cord development GO:0021517 11 9 0,000 6,162E-03 0,01843067 ! protein targeting to ER GO:0045047 19 9 0,000 6,162E-03 0,01840673 ! T cell selection GO:0045058 18 9 0,000 6,162E-03 0,01838286 ! endoderm development GO:0007492 12 9 0,000 6,162E-03 0,01835905 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 6,162E-03 0,0183353 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 6,162E-03 0,01831161 ! arginine catabolic process GO:0006527 10 9 0,000 6,162E-03 0,01828798 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 6,162E-03 0,01826441 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 6,162E-03 0,01824091 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 6,162E-03 0,01821746 ! phosphagen metabolic process GO:0006599 12 9 0,000 6,162E-03 0,01819407 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 6,162E-03 0,01817075 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 6,162E-03 0,01814748 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 6,162E-03 0,01812428 ! regulation of stress fiber formation GO:0051492 20 9 0,000 6,162E-03 0,01810113 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 6,162E-03 0,01807804 ! mannose metabolic process GO:0006013 9 9 0,000 6,162E-03 0,01805501 ! substrate-bound cell migration GO:0006929 10 9 0,000 6,162E-03 0,01803204 ! receptor clustering GO:0043113 15 9 0,000 6,162E-03 0,01800913 ! epithelial cell development GO:0002064 10 9 0,000 6,162E-03 0,01798627 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 6,162E-03 0,01796348 ! retinoic acid metabolic process GO:0042573 11 9 0,000 6,162E-03 0,01794074 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 6,162E-03 0,01791806 ! positive regulation of translational initiation GO:0045948 10 9 0,000 6,162E-03 0,01789543 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 6,162E-03 0,01787287 ! motor axon guidance GO:0008045 14 9 0,000 6,162E-03 0,01785036 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 6,162E-03 0,0178279 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 6,162E-03 0,01780551 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 6,162E-03 0,01778317 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 6,162E-03 0,01776088 ! blastoderm segmentation GO:0007350 11 9 0,000 6,162E-03 0,01773865 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 6,162E-03 0,01771648 ! DNA ligation GO:0006266 14 9 0,000 6,162E-03 0,01769436 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 6,162E-03 0,0176723 ! response to amine stimulus GO:0014075 13 9 0,000 6,162E-03 0,01765029 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 6,162E-03 0,01762834 ! erythrocyte development GO:0048821 11 9 0,000 6,162E-03 0,01760644 ! renal water homeostasis GO:0003091 14 9 0,000 6,162E-03 0,0175846 ! postreplication repair GO:0006301 11 9 0,000 6,162E-03 0,01756281 ! mRNA cleavage GO:0006379 13 9 0,000 6,162E-03 0,01754107 ! hindbrain morphogenesis GO:0021575 12 9 0,000 6,162E-03 0,01751939 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 6,162E-03 0,01749776 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 6,162E-03 0,01747618 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 6,162E-03 0,01745466 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 6,162E-03 0,01743319 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 6,162E-03 0,01741177 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 6,162E-03 0,01739041 ! acid secretion GO:0046717 14 9 0,000 6,162E-03 0,0173691 ! musculoskeletal movement GO:0050881 11 9 0,000 6,162E-03 0,01734784 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 6,162E-03 0,01732663 ! methionine biosynthetic process GO:0009086 10 9 0,000 6,162E-03 0,01730548 ! purine base metabolic process GO:0006144 18 9 0,000 6,162E-03 0,01728437 ! oocyte differentiation GO:0009994 12 9 0,000 6,162E-03 0,01726332 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 6,162E-03 0,01724232 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 6,162E-03 0,01722137 ! spleen development GO:0048536 15 9 0,000 6,162E-03 0,01720047 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 6,162E-03 0,01717962 ! anterior/posterior axis specification GO:0009948 11 9 0,000 6,162E-03 0,01715882 ! regulation of RNA splicing GO:0043484 14 9 0,000 6,162E-03 0,01713807 ! detection of calcium ion GO:0005513 13 9 0,000 6,162E-03 0,01711737 ! blastocyst formation GO:0001825 12 9 0,000 6,162E-03 0,01709672 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 6,162E-03 0,01707613 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 6,162E-03 0,01705558 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 6,162E-03 0,01703508 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 6,162E-03 0,01701463 ! regulation of amino acid transport GO:0051955 11 9 0,000 6,162E-03 0,01699423 ! positive regulation of amine transport GO:0051954 15 9 0,000 6,162E-03 0,01697387 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 6,162E-03 0,01695357 ! prepulse inhibition GO:0060134 14 9 0,000 6,162E-03 0,01693331 ! embryonic placenta development GO:0001892 12 9 0,000 6,162E-03 0,01691311 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 6,162E-03 0,01689295 ! insulin secretion GO:0030073 17 9 0,000 6,162E-03 0,01687284 ! sequestering of metal ion GO:0051238 11 9 0,000 6,162E-03 0,01685278 ! response to nicotine GO:0035094 16 9 0,000 6,162E-03 0,01683276 ! establishment of cell polarity GO:0030010 12 9 0,000 6,162E-03 0,01681279 ! nucleus localization GO:0051647 15 9 0,000 6,162E-03 0,01679287 ! regulation of synapse organization GO:0050807 12 9 0,000 6,162E-03 0,016773 ! localization within membrane GO:0051668 15 9 0,000 6,162E-03 0,01675317 ! negative regulation of muscle development GO:0048635 12 10 0,000 6,845E-03 0,01858681 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 6,845E-03 0,01856489 ! neuron fate specification GO:0048665 11 10 0,000 6,845E-03 0,01854303 ! negative regulation of blood pressure GO:0045776 22 10 0,000 6,845E-03 0,01852121 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 6,845E-03 0,01849945 ! thyroid gland development GO:0030878 19 10 0,000 6,845E-03 0,01847774 ! regulation of B cell proliferation GO:0030888 15 10 0,000 6,845E-03 0,01845607 ! regulation of phosphatase activity GO:0010921 21 10 0,000 6,845E-03 0,01843446 ! synapsis GO:0007129 13 10 0,000 6,845E-03 0,0184129 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 6,845E-03 0,01839139 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 6,845E-03 0,01836993 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 6,845E-03 0,01834852 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 6,845E-03 0,01832716 ! sulfate transport GO:0008272 12 10 0,000 6,845E-03 0,01830585 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 6,845E-03 0,01828459 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 6,845E-03 0,01826338 ! androgen metabolic process GO:0008209 13 10 0,000 6,845E-03 0,01824221 ! phospholipid efflux GO:0033700 16 10 0,000 6,845E-03 0,0182211 ! hippocampus development GO:0021766 19 10 0,000 6,845E-03 0,01820004 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 6,845E-03 0,01817902 ! blood vessel remodeling GO:0001974 21 10 0,000 6,845E-03 0,01815805 ! positive regulation of heart contraction GO:0045823 14 10 0,000 6,845E-03 0,01813713 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 6,845E-03 0,01811626 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 6,845E-03 0,01809544 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 6,845E-03 0,01807466 ! pathogenesis GO:0009405 13 10 0,000 6,845E-03 0,01805393 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 6,845E-03 0,01803325 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 6,845E-03 0,01801262 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 6,845E-03 0,01799203 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 6,845E-03 0,0179715 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 6,845E-03 0,017951 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 6,845E-03 0,01793056 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 6,845E-03 0,01791016 ! melanocyte differentiation GO:0030318 15 10 0,000 6,845E-03 0,01788981 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 6,845E-03 0,0178695 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 6,845E-03 0,01784924 ! reverse cholesterol transport GO:0043691 16 10 0,000 6,845E-03 0,01782903 ! response to X-ray GO:0010165 16 10 0,000 6,845E-03 0,01780886 ! B cell proliferation GO:0042100 14 10 0,000 6,845E-03 0,01778873 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 6,845E-03 0,01776866 ! regulation of sodium ion transport GO:0002028 15 10 0,000 6,845E-03 0,01774862 ! forebrain cell migration GO:0021885 17 10 0,000 6,845E-03 0,01772864 ! lipid digestion GO:0044241 15 10 0,000 6,845E-03 0,0177087 ! phagocytosis, engulfment GO:0006911 20 10 0,000 6,845E-03 0,0176888 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 6,845E-03 0,01766895 ! entry into host cell GO:0030260 20 10 0,000 6,845E-03 0,01764914 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 6,845E-03 0,01762937 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 6,845E-03 0,01760965 ! negative regulation of ossification GO:0030279 19 10 0,000 6,845E-03 0,01758998 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 6,845E-03 0,01757035 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 6,845E-03 0,01755076 ! regulation of bone resorption GO:0045124 24 10 0,000 6,845E-03 0,01753121 ! alpha-beta T cell activation GO:0046631 16 10 0,000 6,845E-03 0,01751171 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 6,845E-03 0,01749226 ! regulation of organ growth GO:0046620 11 10 0,000 6,845E-03 0,01747284 ! response to dsRNA GO:0043331 18 10 0,000 6,845E-03 0,01745347 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 6,845E-03 0,01743414 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 6,845E-03 0,01741486 ! embryonic axis specification GO:0000578 12 10 0,000 6,845E-03 0,01739561 ! regulation of B cell differentiation GO:0045577 16 10 0,000 6,845E-03 0,01737641 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 6,845E-03 0,01735726 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 6,845E-03 0,01733814 ! cranial nerve development GO:0021545 12 10 0,000 6,845E-03 0,01731907 ! fucose catabolic process GO:0019317 16 10 0,000 6,845E-03 0,01730003 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 6,845E-03 0,01728104 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 6,845E-03 0,01726209 ! protein sumoylation GO:0016925 12 10 0,000 6,845E-03 0,01724319 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 6,845E-03 0,01722432 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 6,845E-03 0,0172055 ! zymogen activation GO:0031638 14 10 0,000 6,845E-03 0,01718671 ! salivary gland development GO:0007431 22 10 0,000 6,845E-03 0,01716797 ! negative regulation of neurological system process GO:0031645 19 10 0,000 6,845E-03 0,01714927 ! glutathione biosynthetic process GO:0006750 11 10 0,000 6,845E-03 0,01713061 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 6,845E-03 0,01711199 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 6,845E-03 0,01709341 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 6,845E-03 0,01707487 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 6,845E-03 0,01705637 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 6,845E-03 0,01703791 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 6,845E-03 0,01701949 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 6,845E-03 0,01700111 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 6,845E-03 0,01698277 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 6,845E-03 0,01696447 ! detection of bacterium GO:0016045 10 10 0,000 6,845E-03 0,01694621 ! embryonic gut development GO:0048566 11 10 0,000 6,845E-03 0,01692799 ! activation of innate immune response GO:0002218 10 10 0,000 6,845E-03 0,01690981 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 6,845E-03 0,01689166 ! cardiac cell differentiation GO:0035051 16 10 0,000 6,845E-03 0,01687356 ! developmental induction GO:0031128 13 10 0,000 6,845E-03 0,01685549 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 6,845E-03 0,01683747 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 6,845E-03 0,01681948 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 6,845E-03 0,01680153 ! negative regulation of immune effector process GO:0002698 16 10 0,000 6,845E-03 0,01678361 ! rRNA transcription GO:0009303 17 11 0,000 7,527E-03 0,01843652 ! respiratory burst GO:0045730 14 11 0,000 7,527E-03 0,0184169 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 7,527E-03 0,01839733 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 7,527E-03 0,0183778 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 7,527E-03 0,01835831 ! virus-host interaction GO:0019048 17 11 0,000 7,527E-03 0,01833886 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 7,527E-03 0,01831946 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 7,527E-03 0,01830009 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 7,527E-03 0,01828077 ! Golgi vesicle budding GO:0048194 17 11 0,000 7,527E-03 0,01826149 ! RNA polyadenylation GO:0043631 19 11 0,000 7,527E-03 0,01824224 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 7,527E-03 0,01822304 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 7,527E-03 0,01820388 ! mating GO:0007618 14 11 0,000 7,527E-03 0,01818476 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 7,527E-03 0,01816567 ! T cell proliferation GO:0042098 20 11 0,000 7,527E-03 0,01814663 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 7,527E-03 0,01812763 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 7,527E-03 0,01810867 ! bone resorption GO:0045453 16 11 0,000 7,527E-03 0,01808975 ! regulated secretory pathway GO:0045055 14 11 0,000 7,527E-03 0,01807086 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 7,527E-03 0,01805202 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 7,527E-03 0,01803322 ! regulation of mRNA processing GO:0050684 18 11 0,000 7,527E-03 0,01801445 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 7,527E-03 0,01799573 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 7,527E-03 0,01797704 ! syncytium formation GO:0006949 15 11 0,000 7,527E-03 0,01795839 ! plasma membrane organization GO:0007009 18 11 0,000 7,527E-03 0,01793978 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 7,527E-03 0,01792121 ! focal adhesion formation GO:0048041 24 11 0,000 7,527E-03 0,01790268 ! mitotic spindle organization GO:0007052 15 11 0,000 7,527E-03 0,01788418 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 7,527E-03 0,01786573 ! regulation of intracellular pH GO:0051453 17 11 0,000 7,527E-03 0,01784731 ! membrane protein proteolysis GO:0033619 18 11 0,000 7,527E-03 0,01782893 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 7,527E-03 0,01781058 ! adult heart development GO:0007512 11 11 0,000 7,527E-03 0,01779228 ! chondrocyte differentiation GO:0002062 17 11 0,000 7,527E-03 0,01777401 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 7,527E-03 0,01775578 ! temperature homeostasis GO:0001659 16 11 0,000 7,527E-03 0,01773759 ! L-glutamate transport GO:0015813 16 11 0,000 7,527E-03 0,01771944 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 7,527E-03 0,01770132 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 7,527E-03 0,01768324 ! protein targeting to peroxisome GO:0006625 20 11 0,000 7,527E-03 0,01766519 ! stem cell development GO:0048864 29 11 0,000 7,527E-03 0,01764718 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 7,527E-03 0,01762921 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 7,527E-03 0,01761128 ! regulation of phagocytosis GO:0050764 14 11 0,000 7,527E-03 0,01759338 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 7,527E-03 0,01757552 ! vasoconstriction GO:0042310 15 11 0,000 7,527E-03 0,0175577 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 7,527E-03 0,01753991 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 7,527E-03 0,01752215 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 7,527E-03 0,01750444 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 7,527E-03 0,01748676 ! ribosome assembly GO:0042255 13 11 0,000 7,527E-03 0,01746911 ! nitric oxide metabolic process GO:0046209 14 11 0,000 7,527E-03 0,0174515 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 7,527E-03 0,01743393 ! chromatin silencing GO:0006342 19 11 0,000 7,527E-03 0,01741639 ! nucleosome positioning GO:0016584 13 11 0,000 7,527E-03 0,01739888 ! T cell homeostasis GO:0043029 20 11 0,000 7,527E-03 0,01738141 ! regulation of isotype switching GO:0045191 19 11 0,000 7,527E-03 0,01736398 ! regulation of leukocyte migration GO:0002685 24 11 0,000 7,527E-03 0,01734658 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 7,527E-03 0,01732922 ! protein-chromophore linkage GO:0018298 13 11 0,000 7,527E-03 0,01731189 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 7,527E-03 0,01729459 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 7,527E-03 0,01727733 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 7,527E-03 0,01726011 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 7,527E-03 0,01724292 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 7,527E-03 0,01722576 ! male genitalia development GO:0030539 13 11 0,000 7,527E-03 0,01720864 ! cholesterol efflux GO:0033344 19 11 0,000 7,527E-03 0,01719155 ! digestive tract morphogenesis GO:0048546 15 11 0,000 7,527E-03 0,01717449 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 7,527E-03 0,01715747 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 7,527E-03 0,01714048 ! negative regulation of glucose import GO:0046325 14 11 0,000 7,527E-03 0,01712353 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 7,527E-03 0,01710661 ! regulation of organic acid transport GO:0032890 17 11 0,000 7,527E-03 0,01708972 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 7,527E-03 0,01707287 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 7,527E-03 0,01705605 ! mRNA 3'-end processing GO:0031124 19 11 0,000 7,527E-03 0,01703926 ! lysogeny GO:0030069 18 11 0,000 7,527E-03 0,01702251 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 7,527E-03 0,01700578 ! acrosome reaction GO:0007340 13 11 0,000 7,527E-03 0,0169891 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 7,527E-03 0,01697244 ! lactation GO:0007595 20 12 0,000 8,209E-03 0,01849144 ! reproductive cellular process GO:0048610 14 12 0,000 8,209E-03 0,01847334 ! tRNA modification GO:0006400 14 12 0,000 8,209E-03 0,01845529 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 8,209E-03 0,01843726 ! positive regulation of blood pressure GO:0045777 16 12 0,000 8,209E-03 0,01841928 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 8,209E-03 0,01840132 ! 'de novo' protein folding GO:0006458 18 12 0,000 8,209E-03 0,01838341 ! dicarboxylic acid transport GO:0006835 22 12 0,000 8,209E-03 0,01836552 ! non-recombinational repair GO:0000726 19 12 0,000 8,209E-03 0,01834768 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 8,209E-03 0,01832986 ! peroxisomal transport GO:0043574 21 12 0,000 8,209E-03 0,01831208 ! cartilage condensation GO:0001502 18 12 0,000 8,209E-03 0,01829434 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 8,209E-03 0,01827663 ! cytokine biosynthetic process GO:0042089 16 12 0,000 8,209E-03 0,01825895 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 8,209E-03 0,01824131 ! heart looping GO:0001947 15 12 0,000 8,209E-03 0,0182237 ! palate development GO:0060021 15 12 0,000 8,209E-03 0,01820613 ! positive regulation of cell growth GO:0030307 16 12 0,000 8,209E-03 0,01818859 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 8,209E-03 0,01817109 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 8,209E-03 0,01815361 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 8,209E-03 0,01813618 ! arginine metabolic process GO:0006525 13 12 0,000 8,209E-03 0,01811877 ! glycoprotein catabolic process GO:0006516 19 12 0,000 8,209E-03 0,0181014 ! methionine metabolic process GO:0006555 13 12 0,000 8,209E-03 0,01808406 ! tyrosine metabolic process GO:0006570 14 12 0,000 8,209E-03 0,01806675 ! Golgi organization GO:0007030 18 12 0,000 8,209E-03 0,01804948 ! cell-cell junction assembly GO:0007043 18 12 0,000 8,209E-03 0,01803224 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 8,209E-03 0,01801504 ! monoamine transport GO:0015844 13 12 0,000 8,209E-03 0,01799786 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 8,209E-03 0,01798072 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 8,209E-03 0,01796361 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 8,209E-03 0,01794654 ! L-amino acid transport GO:0015807 20 12 0,000 8,209E-03 0,01792949 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 8,209E-03 0,01791248 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 8,209E-03 0,01789551 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 8,209E-03 0,01787856 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 8,209E-03 0,01786164 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 8,209E-03 0,01784476 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 8,209E-03 0,01782791 ! cerebellum development GO:0021549 13 12 0,000 8,209E-03 0,01781109 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 8,209E-03 0,01779431 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 8,209E-03 0,01777755 ! histone acetylation GO:0016573 23 12 0,000 8,209E-03 0,01776083 ! histone methylation GO:0016571 15 12 0,000 8,209E-03 0,01774413 ! autonomic nervous system development GO:0048483 23 12 0,000 8,209E-03 0,01772747 ! gland morphogenesis GO:0022612 23 12 0,000 8,209E-03 0,01771084 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 8,209E-03 0,01769424 ! peptidyl-lysine modification GO:0018205 18 12 0,000 8,209E-03 0,01767768 ! negative regulation of protein secretion GO:0050709 20 12 0,000 8,209E-03 0,01766114 ! response to gamma radiation GO:0010332 20 12 0,000 8,209E-03 0,01764463 ! regulation of epidermis development GO:0045682 17 12 0,000 8,209E-03 0,01762816 ! intestinal absorption GO:0050892 19 12 0,000 8,209E-03 0,01761171 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 8,209E-03 0,0175953 ! cAMP biosynthetic process GO:0006171 20 12 0,000 8,209E-03 0,01757892 ! regulation of mRNA stability GO:0043488 27 12 0,000 8,209E-03 0,01756257 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 8,209E-03 0,01754624 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 8,209E-03 0,01752995 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 8,209E-03 0,01751369 ! RNA 3'-end processing GO:0031123 20 12 0,000 8,209E-03 0,01749746 ! microspike assembly GO:0030035 23 12 0,000 8,209E-03 0,01748126 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 8,209E-03 0,01746509 ! response to cold GO:0009409 14 12 0,000 8,209E-03 0,01744894 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 8,89E-03 0,01887963 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 8,89E-03 0,01886221 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 8,89E-03 0,01884483 ! cGMP metabolic process GO:0046068 16 13 0,000 8,89E-03 0,01882748 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 8,89E-03 0,01881016 ! water transport GO:0006833 17 13 0,000 8,89E-03 0,01879287 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 8,89E-03 0,01877561 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 8,89E-03 0,01875839 ! lipid localization GO:0010876 24 13 0,000 8,89E-03 0,01874119 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 8,89E-03 0,01872403 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 8,89E-03 0,0187069 ! organelle fusion GO:0048284 28 13 0,000 8,89E-03 0,0186898 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 8,89E-03 0,01867273 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 8,89E-03 0,01865569 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 8,89E-03 0,01863869 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 8,89E-03 0,01862171 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 8,89E-03 0,01860477 ! response to hexose stimulus GO:0009746 19 13 0,000 8,89E-03 0,01858786 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 8,89E-03 0,01857097 ! glutamate metabolic process GO:0006536 18 13 0,000 8,89E-03 0,01855412 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 8,89E-03 0,0185373 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 8,89E-03 0,01852051 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 8,89E-03 0,01850375 ! NAD metabolic process GO:0019674 21 13 0,000 8,89E-03 0,01848702 ! exocrine system development GO:0035272 27 13 0,000 8,89E-03 0,01847032 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 8,89E-03 0,01845365 ! bone mineralization GO:0030282 15 13 0,000 8,89E-03 0,01843701 ! regulation of exocytosis GO:0017157 17 13 0,000 8,89E-03 0,0184204 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 8,89E-03 0,01840382 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 8,89E-03 0,01838727 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 8,89E-03 0,01837075 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 8,89E-03 0,01835426 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 8,89E-03 0,01833779 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 8,89E-03 0,01832136 ! genitalia development GO:0048806 15 13 0,000 8,89E-03 0,01830496 ! regulation of cellular pH GO:0030641 20 13 0,000 8,89E-03 0,01828859 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 8,89E-03 0,01827224 ! cellular pigmentation GO:0033059 24 13 0,000 8,89E-03 0,01825593 ! tissue regeneration GO:0042246 21 13 0,000 8,89E-03 0,01823964 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 8,89E-03 0,01822339 ! cofactor transport GO:0051181 19 13 0,000 8,89E-03 0,01820716 ! NADP metabolic process GO:0006739 18 13 0,000 8,89E-03 0,01819096 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 8,89E-03 0,01817479 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 8,89E-03 0,01815865 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 8,89E-03 0,01814254 ! gas transport GO:0015669 18 13 0,000 8,89E-03 0,01812645 ! regulation of RNA stability GO:0043487 28 13 0,000 8,89E-03 0,0181104 ! heme biosynthetic process GO:0006783 20 13 0,000 8,89E-03 0,01809437 ! regulation of axon extension GO:0030516 23 13 0,000 8,89E-03 0,01807837 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 8,89E-03 0,0180624 ! lymphocyte homeostasis GO:0002260 24 13 0,000 8,89E-03 0,01804646 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 8,89E-03 0,01803055 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 8,89E-03 0,01801466 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 8,89E-03 0,0179988 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 8,89E-03 0,01798297 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 9,571E-03 0,01934318 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 9,571E-03 0,0193262 ! superoxide anion generation GO:0042554 18 14 0,000 9,571E-03 0,01930924 ! neuron maturation GO:0042551 21 14 0,000 9,571E-03 0,01929232 ! regulation of S phase GO:0033261 18 14 0,000 9,571E-03 0,01927543 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 9,571E-03 0,01925856 ! myotube differentiation GO:0014902 21 14 0,000 9,571E-03 0,01924173 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 9,571E-03 0,01922492 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 9,571E-03 0,01920815 ! heterophilic cell adhesion GO:0007157 29 14 0,000 9,571E-03 0,0191914 ! inositol metabolic process GO:0006020 20 14 0,000 9,571E-03 0,01917468 ! aminoglycan catabolic process GO:0006026 18 14 0,000 9,571E-03 0,019158 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 9,571E-03 0,01914134 ! retina development in camera-type eye GO:0060041 18 14 0,000 9,571E-03 0,01912471 ! cardiac muscle contraction GO:0060048 23 14 0,000 9,571E-03 0,01910811 ! gene silencing by RNA GO:0031047 20 14 0,000 9,571E-03 0,01909153 ! response to cAMP GO:0051591 19 14 0,000 9,571E-03 0,01907499 ! limbic system development GO:0021761 25 14 0,000 9,571E-03 0,01905847 ! startle response GO:0001964 21 14 0,000 9,571E-03 0,01904199 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 9,571E-03 0,01902553 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 9,571E-03 0,0190091 ! activation of MAPKK activity GO:0000186 21 14 0,000 9,571E-03 0,0189927 ! regulation of defense response to virus GO:0050688 24 14 0,000 9,571E-03 0,01897633 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 9,571E-03 0,01895998 ! epidermis morphogenesis GO:0048730 29 14 0,000 9,571E-03 0,01894366 ! glycine metabolic process GO:0006544 22 14 0,000 9,571E-03 0,01892738 ! pituitary gland development GO:0021983 23 14 0,000 9,571E-03 0,01891111 ! cellular response to starvation GO:0009267 21 14 0,000 9,571E-03 0,01889488 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 9,571E-03 0,01887868 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 9,571E-03 0,0188625 ! regulation of heart rate GO:0002027 23 14 0,000 9,571E-03 0,01884635 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 9,571E-03 0,01883023 ! negative regulation of caspase activity GO:0043154 20 14 0,000 9,571E-03 0,01881413 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 9,571E-03 0,01879807 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 9,571E-03 0,01878203 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 9,571E-03 0,01876602 ! G1/S transition checkpoint GO:0031575 33 14 0,000 9,571E-03 0,01875003 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 9,571E-03 0,01873407 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 9,571E-03 0,01871814 ! axon cargo transport GO:0008088 27 14 0,000 9,571E-03 0,01870224 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 9,571E-03 0,01868636 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 9,571E-03 0,01867052 ! DNA unwinding during replication GO:0006268 21 14 0,000 9,571E-03 0,01865469 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 9,571E-03 0,0186389 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 9,571E-03 0,01862313 ! mRNA splice site selection GO:0006376 26 14 0,000 9,571E-03 0,01860739 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 9,571E-03 0,01859167 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 9,571E-03 0,01857598 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 9,571E-03 0,01856032 ! sphingolipid catabolic process GO:0030149 23 14 0,000 9,571E-03 0,01854468 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 9,571E-03 0,01852907 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 9,571E-03 0,01851349 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 9,571E-03 0,01849793 ! muscle maintenance GO:0046716 19 14 0,000 9,571E-03 0,0184824 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 9,571E-03 0,01846689 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 9,571E-03 0,01845141 ! regulation of ATPase activity GO:0043462 18 14 0,000 9,571E-03 0,01843596 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 9,571E-03 0,01842053 ! cell killing GO:0001906 20 14 0,000 9,571E-03 0,01840513 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 9,571E-03 0,01838976 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 9,571E-03 0,01837441 ! cilium assembly GO:0042384 20 14 0,000 9,571E-03 0,01835908 ! peptide hormone secretion GO:0030072 23 14 0,000 9,571E-03 0,01834378 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,01025106 0,01963151 ! positive regulation of cell size GO:0045793 20 15 0,000 0,01025106 0,01961518 ! metencephalon development GO:0022037 19 15 0,000 0,01025106 0,01959888 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,01025106 0,0195826 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,01025106 0,01956635 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,01025106 0,01955012 ! skin development GO:0043588 25 15 0,000 0,01025106 0,01953392 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,01025106 0,01951775 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,01025106 0,01950161 ! lipid phosphorylation GO:0046834 23 15 0,000 0,01025106 0,01948549 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,01025106 0,0194694 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,01025106 0,01945334 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,01025106 0,0194373 ! bile acid metabolic process GO:0008206 22 15 0,000 0,01025106 0,01942129 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,01025106 0,01940531 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,01025106 0,01938935 ! adult walking behavior GO:0007628 25 15 0,000 0,01025106 0,01937342 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,01025106 0,01935751 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,01025106 0,01934163 ! myoblast differentiation GO:0045445 27 15 0,000 0,01025106 0,01932578 ! centrosome cycle GO:0007098 16 15 0,000 0,01025106 0,01930995 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,01025106 0,01929415 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,01025106 0,01927837 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,01025106 0,01926262 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,01025106 0,0192469 ! cerebral cortex development GO:0021987 29 15 0,000 0,01025106 0,0192312 ! response to osmotic stress GO:0006970 22 15 0,000 0,01025106 0,01921552 ! vesicle coating GO:0006901 25 15 0,000 0,01025106 0,01919988 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,01025106 0,01918425 ! DNA integration GO:0015074 22 15 0,000 0,01025106 0,01916866 ! peptide secretion GO:0002790 27 15 0,000 0,01025106 0,01915308 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,01025106 0,01913754 ! regulation of vasodilation GO:0042312 24 15 0,000 0,01025106 0,01912202 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,01025106 0,01910652 ! neuron recognition GO:0008038 22 15 0,000 0,01025106 0,01909105 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,01025106 0,0190756 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,01025106 0,01906018 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,01025106 0,01904479 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,01025106 0,01902942 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,01025106 0,01901407 ! biomineral formation GO:0031214 18 15 0,000 0,01025106 0,01899875 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,01025106 0,01898345 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,01025106 0,01896818 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,01025106 0,01895293 ! dopamine metabolic process GO:0042417 30 15 0,000 0,01025106 0,01893771 ! organic cation transport GO:0015695 19 15 0,000 0,01025106 0,01892251 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,01025106 0,01890734 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,01025106 0,01889219 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,01025106 0,01887706 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,01025106 0,01886196 ! defense response to virus GO:0051607 27 15 0,000 0,01025106 0,01884688 ! peptide hormone processing GO:0016486 19 15 0,000 0,01025106 0,01883183 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,01025106 0,0188168 ! protein secretion GO:0009306 27 16 0,000 0,01093103 0,02004894 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,01093103 0,02003297 ! hormone secretion GO:0046879 25 16 0,000 0,01093103 0,02001702 ! bone remodeling GO:0046849 24 16 0,000 0,01093103 0,02000109 ! endothelial cell migration GO:0043542 22 16 0,000 0,01093103 0,01998519 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,01093103 0,01996932 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,01093103 0,01995347 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,01093103 0,01993765 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,01093103 0,01992185 ! glial cell development GO:0021782 24 16 0,000 0,01093103 0,01990607 ! patterning of blood vessels GO:0001569 24 16 0,000 0,01093103 0,01989033 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,01093103 0,0198746 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,01093103 0,0198589 ! protein polyubiquitination GO:0000209 26 16 0,000 0,01093103 0,01984323 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,01093103 0,01982758 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,01093103 0,01981196 ! fructose metabolic process GO:0006000 20 16 0,000 0,01093103 0,01979636 ! regulation of protein binding GO:0043393 27 16 0,000 0,01093103 0,01978078 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,01093103 0,01976523 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,01093103 0,0197497 ! protein export from nucleus GO:0006611 24 16 0,000 0,01093103 0,0197342 ! negative regulation of immune response GO:0050777 28 16 0,000 0,01093103 0,01971872 ! DNA replication initiation GO:0006270 25 16 0,000 0,01093103 0,01970327 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,01093103 0,01968784 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,01093103 0,01967243 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,01093103 0,01965705 ! diencephalon development GO:0021536 25 16 0,000 0,01093103 0,0196417 ! oogenesis GO:0048477 23 16 0,000 0,01093103 0,01962636 ! neural crest cell migration GO:0001755 24 16 0,000 0,01093103 0,01961105 ! G1 phase GO:0051318 27 16 0,000 0,01093103 0,01959577 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,01093103 0,01958051 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,01093103 0,01956527 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,01093103 0,01955006 ! steroid catabolic process GO:0006706 22 16 0,000 0,01093103 0,01953487 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,01093103 0,0195197 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,01093103 0,01950456 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,01093103 0,01948944 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,01093103 0,01947434 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,01093103 0,01945927 ! sperm-egg recognition GO:0035036 16 16 0,000 0,01093103 0,01944422 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,01093103 0,01942919 ! nerve development GO:0021675 18 16 0,000 0,01093103 0,01941419 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,01093103 0,01939921 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,01093103 0,01938425 ! negative regulation of translation GO:0017148 22 16 0,000 0,01093103 0,01936932 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,01161057 0,02055759 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,01161057 0,02054178 ! negative regulation of defense response GO:0031348 19 17 0,000 0,01161057 0,02052599 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,01161057 0,02051022 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,01161057 0,02049448 ! glycerol metabolic process GO:0006071 20 17 0,000 0,01161057 0,02047877 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,01161057 0,02046307 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,01161057 0,02044741 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,01161057 0,02043176 ! signal complex assembly GO:0007172 29 17 0,000 0,01161057 0,02041614 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,01161057 0,02040054 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,01161057 0,02038497 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,01161057 0,02036942 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,01161057 0,0203539 ! memory GO:0007613 25 17 0,000 0,01161057 0,02033839 ! keratinization GO:0031424 17 17 0,000 0,01161057 0,02032292 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,01161057 0,02030746 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,01161057 0,02029203 ! retinoid metabolic process GO:0001523 22 17 0,000 0,01161057 0,02027662 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,01161057 0,02026124 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,01161057 0,02024588 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,01161057 0,02023054 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,01161057 0,02021522 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,01161057 0,02019993 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,01161057 0,02018466 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,01161057 0,02016942 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,01161057 0,0201542 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,01161057 0,020139 ! membrane budding GO:0006900 29 17 0,000 0,01161057 0,02012382 ! heme metabolic process GO:0042168 27 17 0,000 0,01161057 0,02010867 ! actin filament bundle formation GO:0051017 26 17 0,000 0,01161057 0,02009354 ! neuromuscular junction development GO:0007528 23 17 0,000 0,01161057 0,02007843 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,01161057 0,02006334 ! body fluid secretion GO:0007589 27 17 0,000 0,01161057 0,02004828 ! stem cell differentiation GO:0048863 36 17 0,000 0,01161057 0,02003324 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,01161057 0,02001822 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,01161057 0,02000323 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,01161057 0,01998826 ! sensory perception of pain GO:0019233 23 17 0,000 0,01161057 0,01997331 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,01161057 0,01995838 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,01161057 0,01994347 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,01161057 0,01992859 ! synaptogenesis GO:0007416 24 17 0,000 0,01161057 0,01991373 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,01161057 0,01989889 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,01161057 0,01988407 ! cell-cell junction organization GO:0045216 25 17 0,000 0,01161057 0,01986928 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,01161057 0,01985451 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,01161057 0,01983976 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,01161057 0,01982503 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,01161057 0,01981032 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,01161057 0,01979563 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,01161057 0,01978097 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,01228968 0,02092248 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,01228968 0,020907 ! positive regulation of translation GO:0045727 28 18 0,000 0,01228968 0,02089155 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,01228968 0,02087612 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,01228968 0,02086071 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,01228968 0,02084533 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,01228968 0,02082997 ! cAMP metabolic process GO:0046058 33 18 0,000 0,01228968 0,02081463 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,01228968 0,02079931 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,01228968 0,02078402 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,01228968 0,02076875 ! axis specification GO:0009798 26 18 0,000 0,01228968 0,0207535 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,01228968 0,02073827 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,01228968 0,02072307 ! pancreas development GO:0031016 26 18 0,000 0,01228968 0,02070789 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,01228968 0,02069273 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,01228968 0,02067759 ! glutamine metabolic process GO:0006541 23 18 0,000 0,01228968 0,02066248 ! response to retinoic acid GO:0032526 25 18 0,000 0,01228968 0,02064738 ! pigmentation during development GO:0048066 31 18 0,000 0,01228968 0,02063231 ! central nervous system neuron development GO:0021954 30 18 0,000 0,01228968 0,02061726 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,01228968 0,02060224 ! fucose metabolic process GO:0006004 26 18 0,000 0,01228968 0,02058723 ! response to fungus GO:0009620 19 18 0,000 0,01228968 0,02057225 ! peptide cross-linking GO:0018149 31 18 0,000 0,01228968 0,02055728 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,01228968 0,02054235 ! heart process GO:0003015 27 18 0,000 0,01228968 0,02052743 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,01228968 0,02051253 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,01228968 0,02049766 ! visual learning GO:0008542 35 18 0,000 0,01228968 0,0204828 ! somitogenesis GO:0001756 24 18 0,000 0,01228968 0,02046797 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,01228968 0,02045316 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,01228968 0,02043837 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,01228968 0,0204236 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,01228968 0,02040886 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,01228968 0,02039413 ! vitamin transport GO:0051180 24 18 0,000 0,01228968 0,02037943 ! hormone transport GO:0009914 27 18 0,000 0,01228968 0,02036475 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,01228968 0,02035008 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,01228968 0,02033544 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,01228968 0,02032082 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,01228968 0,02030623 ! cell-cell recognition GO:0009988 20 18 0,000 0,01228968 0,02029165 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,01228968 0,02027709 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,01228968 0,02026256 ! regulation of glucose import GO:0046324 21 18 0,000 0,01228968 0,02024804 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,01228968 0,02023355 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,01228968 0,02021907 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,01228968 0,02020462 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,01228968 0,02019019 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,01296836 0,02128996 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,01296836 0,02127478 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,01296836 0,02125961 ! positive regulation of ossification GO:0045778 30 19 0,000 0,01296836 0,02124447 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,01296836 0,02122935 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,01296836 0,02121425 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,01296836 0,02119917 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,01296836 0,02118412 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,01296836 0,02116908 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,01296836 0,02115407 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,01296836 0,02113908 ! regeneration GO:0031099 32 19 0,000 0,01296836 0,02112411 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,01296836 0,02110916 ! response to alkaloid GO:0043279 32 19 0,000 0,01296836 0,02109423 ! sensory perception of taste GO:0050909 23 19 0,000 0,01296836 0,02107932 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,01296836 0,02106443 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,01296836 0,02104957 ! smooth muscle contraction GO:0006939 36 19 0,000 0,01296836 0,02103472 ! peroxisome organization GO:0007031 29 19 0,000 0,01296836 0,0210199 ! digestive system process GO:0022600 30 19 0,000 0,01296836 0,0210051 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,01296836 0,02099032 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,01296836 0,02097555 ! response to vitamin A GO:0033189 26 19 0,000 0,01296836 0,02096081 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,01296836 0,02094609 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,01296836 0,0209314 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,01296836 0,02091672 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,01296836 0,02090206 ! response to starvation GO:0042594 30 19 0,000 0,01296836 0,02088742 ! sex determination GO:0007530 29 19 0,000 0,01296836 0,0208728 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,01296836 0,02085821 ! plasma membrane fusion GO:0045026 23 19 0,000 0,01296836 0,02084363 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,01296836 0,02082908 ! cytolysis GO:0019835 20 19 0,000 0,01296836 0,02081454 ! renal system process GO:0003014 35 19 0,000 0,01296836 0,02080003 ! vasodilation GO:0042311 33 19 0,000 0,01296836 0,02078553 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,01296836 0,02077106 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,01296836 0,0207566 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,01296836 0,02074217 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,01296836 0,02072775 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,01296836 0,02071336 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,01296836 0,02069899 ! sarcomere organization GO:0045214 23 19 0,000 0,01296836 0,02068463 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,01296836 0,0206703 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,01296836 0,02065598 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,01296836 0,02064169 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,01296836 0,02062741 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,01296836 0,02061316 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,01296836 0,02059892 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,01296836 0,02058471 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,01296836 0,02057051 ! protein stabilization GO:0050821 26 19 0,000 0,01296836 0,02055633 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,01364662 0,02161655 ! iron ion transport GO:0006826 37 20 0,000 0,01364662 0,02160167 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,01364662 0,02158681 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,01364662 0,02157198 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,01364662 0,02155716 ! response to vitamin GO:0033273 29 20 0,000 0,01364662 0,02154237 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,01364662 0,02152759 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,01364662 0,02151284 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,01364662 0,0214981 ! spinal cord development GO:0021510 31 20 0,000 0,01364662 0,02148339 ! response to ethanol GO:0045471 37 20 0,000 0,01364662 0,02146869 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,01364662 0,02145402 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,01364662 0,02143936 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,01364662 0,02142473 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,01364662 0,02141011 ! chromosome condensation GO:0030261 31 20 0,000 0,01364662 0,02139552 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,01364662 0,02138094 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,01364662 0,02136639 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,01364662 0,02135185 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,01364662 0,02133734 ! pallium development GO:0021543 38 20 0,000 0,01364662 0,02132284 ! DNA modification GO:0006304 28 20 0,000 0,01364662 0,02130837 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,01364662 0,02129391 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,01364662 0,02127948 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,01364662 0,02126506 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,01364662 0,02125066 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,01364662 0,02123628 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,01364662 0,02122192 ! collagen catabolic process GO:0030574 25 20 0,000 0,01364662 0,02120759 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,01364662 0,02119327 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,01364662 0,02117897 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,01364662 0,02116468 ! alditol metabolic process GO:0019400 24 20 0,000 0,01364662 0,02115042 ! actin filament-based movement GO:0030048 34 20 0,000 0,01364662 0,02113618 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,01432445 0,02217108 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,01432445 0,02215617 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,01432445 0,02214128 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,01432445 0,02212641 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,01432445 0,02211156 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,01432445 0,02209673 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,01432445 0,02208192 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,01432445 0,02206713 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,01432445 0,02205236 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,01432445 0,02203761 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,01432445 0,02202288 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,01432445 0,02200817 ! protein amino acid acylation GO:0043543 37 21 0,000 0,01432445 0,02199348 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,01432445 0,02197881 ! vesicle docking GO:0048278 27 21 0,000 0,01432445 0,02196415 ! phototransduction GO:0007602 25 21 0,000 0,01432445 0,02194952 ! dendrite development GO:0016358 35 21 0,000 0,01432445 0,02193491 ! visual behavior GO:0007632 39 21 0,000 0,01432445 0,02192031 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,01432445 0,02190574 ! ovarian follicle development GO:0001541 30 21 0,000 0,01432445 0,02189118 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,01432445 0,02187665 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,01432445 0,02186213 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,01432445 0,02184763 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,01432445 0,02183316 ! cell aging GO:0007569 32 21 0,000 0,01432445 0,0218187 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,01432445 0,02180426 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,01432445 0,02178984 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,01432445 0,02177543 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,01432445 0,02176105 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,01432445 0,02174669 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,01432445 0,02173234 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,01432445 0,02171802 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,01432445 0,02170371 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,01432445 0,02168942 ! fatty acid transport GO:0015908 30 21 0,000 0,01432445 0,02167515 ! immunoglobulin production GO:0002377 33 21 0,000 0,01432445 0,0216609 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,01432445 0,02164667 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,01432445 0,02163246 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,01432445 0,02161826 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,01432445 0,02160409 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,01432445 0,02158993 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,01432445 0,02157579 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,01432445 0,02156167 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,01432445 0,02154757 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,01432445 0,02153348 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,01432445 0,02151942 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,01432445 0,02150537 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,01432445 0,02149134 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,01432445 0,02147733 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,01432445 0,02146334 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,01432445 0,02144937 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,01500185 0,02244909 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,01500185 0,0224345 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,01500185 0,02241992 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,01500185 0,02240536 ! viral genome replication GO:0019079 29 22 0,000 0,01500185 0,02239082 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,01500185 0,0223763 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,01500185 0,0223618 ! leukocyte adhesion GO:0007159 38 22 0,000 0,01500185 0,02234732 ! molting cycle process GO:0022404 40 22 0,000 0,01500185 0,02233285 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,01500185 0,02231841 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,01500185 0,02230398 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,01500185 0,02228957 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,01500185 0,02227518 ! vasculogenesis GO:0001570 33 22 0,000 0,01500185 0,02226081 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,01500185 0,02224646 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,01500185 0,02223212 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,01500185 0,02221781 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,01500185 0,02220351 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,01500185 0,02218923 ! lysosome organization GO:0007040 37 22 0,000 0,01500185 0,02217497 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,01500185 0,02216073 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,01500185 0,02214651 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,01500185 0,0221323 ! regulation of behavior GO:0050795 38 22 0,000 0,01500185 0,02211811 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,01500185 0,02210394 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,01500185 0,02208979 ! membrane depolarization GO:0051899 35 22 0,000 0,01500185 0,02207566 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,01500185 0,02206154 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,01500185 0,02204745 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,01500185 0,02203337 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,01500185 0,02201931 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,01500185 0,02200526 ! blastocyst development GO:0001824 37 22 0,000 0,01500185 0,02199124 ! neural tube closure GO:0001843 33 22 0,000 0,01500185 0,02197723 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,01500185 0,02196324 ! protein tetramerization GO:0051262 39 22 0,000 0,01500185 0,02194927 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,01567882 0,02292517 ! neuron fate commitment GO:0048663 32 23 0,000 0,01567882 0,02291061 ! embryonic pattern specification GO:0009880 31 23 0,000 0,01567882 0,02289606 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,01567882 0,02288153 ! myelination GO:0042552 35 23 0,000 0,01567882 0,02286702 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,01567882 0,02285253 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,01567882 0,02283806 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,01567882 0,02282361 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,01567882 0,02280917 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,01567882 0,02279475 ! vesicle targeting GO:0006903 32 23 0,000 0,01567882 0,02278035 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,01567882 0,02276597 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,01567882 0,02275161 ! osteoblast differentiation GO:0001649 40 23 0,000 0,01567882 0,02273726 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,01567882 0,02272293 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,01567882 0,02270863 ! interaction with host GO:0051701 37 23 0,000 0,01567882 0,02269433 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,01567882 0,02268006 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,01567882 0,02266581 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,01567882 0,02265157 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,01567882 0,02263735 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,01567882 0,02262315 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,01567882 0,02260896 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,01567882 0,0225948 ! cell fate determination GO:0001709 45 23 0,000 0,01567882 0,02258065 ! pentose metabolic process GO:0019321 31 23 0,000 0,01567882 0,02256652 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,01567882 0,02255241 ! spermatid development GO:0007286 33 23 0,000 0,01567882 0,02253831 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,01567882 0,02252423 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,01567882 0,02251017 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,01567882 0,02249613 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,01567882 0,02248211 ! telomere organization GO:0032200 32 23 0,000 0,01567882 0,0224681 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,01567882 0,02245411 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,01567882 0,02244013 ! regulation of amine transport GO:0051952 38 23 0,000 0,01567882 0,02242618 ! liver development GO:0001889 40 23 0,000 0,01567882 0,02241224 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,01635537 0,02336482 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,01635537 0,02335032 ! initiation of viral infection GO:0019059 42 24 0,000 0,01635537 0,02333583 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,01635537 0,02332136 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,01635537 0,02330691 ! superoxide metabolic process GO:0006801 32 24 0,000 0,01635537 0,02329248 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,01635537 0,02327807 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,01635537 0,02326367 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,01635537 0,02324929 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,01635537 0,02323493 ! sperm motility GO:0030317 27 24 0,000 0,01635537 0,02322059 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,01635537 0,02320627 ! vacuole organization GO:0007033 39 24 0,000 0,01635537 0,02319196 ! receptor metabolic process GO:0043112 37 24 0,000 0,01635537 0,02317767 ! neural crest cell development GO:0014032 39 24 0,000 0,01635537 0,0231634 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,01635537 0,02314914 ! primary neural tube formation GO:0014020 35 24 0,000 0,01635537 0,02313491 ! negative regulation of cell development GO:0010721 56 24 0,000 0,01635537 0,02312069 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,01635537 0,02310649 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,01635537 0,0230923 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,01635537 0,02307813 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,01635537 0,02306398 ! glutathione metabolic process GO:0006749 29 24 0,000 0,01635537 0,02304985 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,01635537 0,02303574 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,01635537 0,02302164 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,01635537 0,02300756 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,01703149 0,02394403 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,01703149 0,02392941 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,01703149 0,0239148 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,01703149 0,02390021 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,01703149 0,02388563 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,01703149 0,02387108 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,01703149 0,02385654 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,01703149 0,02384202 ! peptide transport GO:0015833 43 25 0,000 0,01703149 0,02382752 ! male gonad development GO:0008584 33 25 0,000 0,01703149 0,02381303 ! iron ion homeostasis GO:0055072 39 25 0,000 0,01703149 0,02379856 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,01703149 0,02378412 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,01703149 0,02376968 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,01703149 0,02375527 ! phospholipid transport GO:0015914 35 25 0,000 0,01703149 0,02374087 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,01703149 0,02372649 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,01703149 0,02371213 ! detection of light stimulus GO:0009583 30 25 0,000 0,01703149 0,02369778 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,01703149 0,02368346 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,01703149 0,02366915 ! leukocyte proliferation GO:0070661 39 25 0,000 0,01703149 0,02365485 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,01703149 0,02364058 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,01770719 0,02456365 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,01770719 0,02454885 ! translational initiation GO:0006413 43 26 0,000 0,01770719 0,02453406 ! regulation of pH GO:0006885 36 26 0,000 0,01770719 0,02451929 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,01770719 0,02450454 ! circadian rhythm GO:0007623 42 26 0,000 0,01770719 0,0244898 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,01770719 0,02447508 ! post-embryonic development GO:0009791 42 26 0,000 0,01770719 0,02446038 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,01770719 0,0244457 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,01770719 0,02443104 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,01770719 0,02441639 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,01770719 0,02440176 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,01770719 0,02438715 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,01770719 0,02437255 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,01770719 0,02435798 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,01770719 0,02434342 ! regulation of coagulation GO:0050818 39 26 0,000 0,01770719 0,02432888 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,01838246 0,02524159 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,01838246 0,02522653 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,01838246 0,02521148 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,01838246 0,02519646 ! membrane docking GO:0022406 39 27 0,000 0,01838246 0,02518145 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,01838246 0,02516646 ! catechol metabolic process GO:0009712 43 27 0,000 0,01838246 0,02515149 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,01838246 0,02513654 ! acute-phase response GO:0006953 42 27 0,000 0,01838246 0,0251216 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,01838246 0,02510669 ! myofibril assembly GO:0030239 36 27 0,000 0,01838246 0,02509179 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,01838246 0,0250769 ! response to ionizing radiation GO:0010212 47 27 0,000 0,01838246 0,02506204 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,01838246 0,02504719 ! natural killer cell activation GO:0030101 35 27 0,000 0,01838246 0,02503236 ! lipid oxidation GO:0034440 38 27 0,000 0,01838246 0,02501755 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,01838246 0,02500276 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,01838246 0,02498798 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,01838246 0,02497322 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,01838246 0,02495848 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,01838246 0,02494375 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,01838246 0,02492904 ! gene silencing GO:0016458 41 27 0,000 0,01838246 0,02491435 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,01905731 0,02581378 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,01905731 0,02579859 ! phenol metabolic process GO:0018958 44 28 0,000 0,01905731 0,02578341 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,01905731 0,02576825 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,01905731 0,02575311 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,01905731 0,02573799 ! cell junction assembly GO:0034329 56 28 0,000 0,01905731 0,02572289 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,01905731 0,0257078 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,01905731 0,02569273 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,01905731 0,02567768 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,01905731 0,02566265 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,01905731 0,02564763 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,01905731 0,02563263 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,01905731 0,02561765 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,01905731 0,02560269 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,01905731 0,02558774 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,01905731 0,02557281 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,01905731 0,0255579 ! mesoderm formation GO:0001707 46 28 0,000 0,01905731 0,02554301 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,01905731 0,02552813 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,01905731 0,02551327 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,01905731 0,02549843 ! ensheathment of neurons GO:0007272 43 28 0,000 0,01905731 0,02548361 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,01905731 0,0254688 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,01905731 0,02545401 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,01905731 0,02543923 ! neural tube formation GO:0001841 41 28 0,000 0,01905731 0,02542448 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,01905731 0,02540974 ! placenta development GO:0001890 37 28 0,000 0,01905731 0,02539502 ! regulation of B cell activation GO:0050864 42 28 0,000 0,01905731 0,02538031 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,01973172 0,02626329 ! regulation of innate immune response GO:0045088 38 29 0,000 0,01973172 0,0262481 ! ovulation cycle process GO:0022602 41 29 0,000 0,01973172 0,02623293 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,01973172 0,02621777 ! protein targeting to membrane GO:0006612 53 29 0,000 0,01973172 0,02620264 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,01973172 0,02618752 ! mismatch repair GO:0006298 34 29 0,000 0,01973172 0,02617241 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,01973172 0,02615733 ! muscle cell development GO:0055001 38 29 0,000 0,01973172 0,02614226 ! formation of primary germ layer GO:0001704 48 29 0,000 0,01973172 0,02612721 ! telencephalon development GO:0021537 52 29 0,000 0,01973172 0,02611218 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,01973172 0,02609716 ! eye morphogenesis GO:0048592 51 29 0,000 0,01973172 0,02608216 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,01973172 0,02606718 ! tissue homeostasis GO:0001894 42 29 0,000 0,01973172 0,02605222 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,02040572 0,02692665 ! collagen metabolic process GO:0032963 40 30 0,000 0,02040572 0,02691121 ! organic anion transport GO:0015711 51 30 0,000 0,02040572 0,02689579 ! cholesterol transport GO:0030301 46 30 0,000 0,02040572 0,02688039 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,02040572 0,026865 ! spliceosome assembly GO:0000245 49 30 0,000 0,02040572 0,02684963 ! spindle organization GO:0007051 37 30 0,000 0,02040572 0,02683428 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,02040572 0,02681894 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,02040572 0,02680363 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,02040572 0,02678833 ! ceramide metabolic process GO:0006672 43 30 0,000 0,02040572 0,02677305 ! ovulation cycle GO:0042698 43 30 0,000 0,02040572 0,02675778 ! hindbrain development GO:0030902 45 30 0,000 0,02040572 0,02674254 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,02040572 0,02672731 ! adult locomotory behavior GO:0008344 47 30 0,000 0,02040572 0,0267121 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,02040572 0,0266969 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,02040572 0,02668172 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,02040572 0,02666656 ! response to heat GO:0009408 41 30 0,000 0,02040572 0,02665142 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,02040572 0,0266363 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,02040572 0,02662119 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,02107929 0,02748433 ! negative regulation of secretion GO:0051048 49 31 0,000 0,02107929 0,02746876 ! mammary gland development GO:0030879 57 31 0,000 0,02107929 0,02745321 ! glial cell differentiation GO:0010001 55 31 0,000 0,02107929 0,02743767 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,02107929 0,02742215 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,02107929 0,02740665 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,02107929 0,02739116 ! odontogenesis GO:0042476 50 31 0,000 0,02107929 0,0273757 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,02107929 0,02736025 ! segmentation GO:0035282 41 31 0,000 0,02107929 0,02734482 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,02107929 0,0273294 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,02107929 0,02731401 ! metanephros development GO:0001656 58 31 0,000 0,02107929 0,02729863 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,02107929 0,02728326 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,02107929 0,02726792 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,02107929 0,02725259 ! cell fate specification GO:0001708 37 31 0,000 0,02107929 0,02723728 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,02107929 0,02722199 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,02107929 0,02720671 ! RNA modification GO:0009451 40 31 0,000 0,02107929 0,02719145 ! regulation of muscle development GO:0048634 48 32 0,000 0,02175243 0,02804406 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,02175243 0,02802834 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,02175243 0,02801265 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,02175243 0,02799698 ! meiosis I GO:0007127 52 32 0,000 0,02175243 0,02798132 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,02175243 0,02796568 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,02175243 0,02795005 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,02175243 0,02793445 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,02175243 0,02791886 ! peripheral nervous system development GO:0007422 53 32 0,000 0,02175243 0,02790329 ! regulation of protein stability GO:0031647 48 32 0,000 0,02175243 0,02788773 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,02175243 0,0278722 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,02175243 0,02785668 ! cytokine production GO:0001816 44 32 0,000 0,02175243 0,02784118 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,02175243 0,02782569 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,02175243 0,02781022 ! vesicle localization GO:0051648 47 32 0,000 0,02175243 0,02779477 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,02242515 0,02863845 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,02242515 0,02862256 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,02242515 0,02860668 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,02242515 0,02859083 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,02242515 0,02857499 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,02242515 0,02855916 ! sister chromatid segregation GO:0000819 46 33 0,000 0,02242515 0,02854336 ! ear morphogenesis GO:0042471 42 33 0,000 0,02242515 0,02852757 ! actomyosin structure organization GO:0031032 43 33 0,000 0,02242515 0,0285118 ! cell junction organization GO:0034330 63 33 0,000 0,02242515 0,02849605 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,02242515 0,02848032 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,02242515 0,0284646 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,02242515 0,0284489 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,02242515 0,02843321 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,02242515 0,02841755 ! female gonad development GO:0008585 49 33 0,000 0,02242515 0,0284019 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,02242515 0,02838627 ! positive regulation of cell development GO:0010720 54 33 0,000 0,02242515 0,02837066 ! lipid homeostasis GO:0055088 55 33 0,000 0,02242515 0,02835506 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,02242515 0,02833948 ! regulation of proteolysis GO:0030162 50 33 0,000 0,02242515 0,02832392 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,02242515 0,02830837 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,02242515 0,02829284 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,02242515 0,02827733 ! cytokinesis GO:0000910 52 33 0,000 0,02242515 0,02826184 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,02242515 0,02824636 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,02309745 0,02907725 ! mRNA catabolic process GO:0006402 48 34 0,000 0,02309745 0,02906134 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,02309745 0,02904545 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,02309745 0,02902958 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,02309745 0,02901373 ! feeding behavior GO:0007631 45 34 0,000 0,02309745 0,02899789 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,02309745 0,02898207 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,02309745 0,02896627 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,02309745 0,02895048 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,02309745 0,02893471 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,02309745 0,02891896 ! neuron migration GO:0001764 46 34 0,000 0,02309745 0,02890323 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,02309745 0,02888751 ! female gamete generation GO:0007292 43 34 0,000 0,02309745 0,02887181 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,02309745 0,02885613 ! polyol metabolic process GO:0019751 44 34 0,000 0,02309745 0,02884046 ! aerobic respiration GO:0009060 47 34 0,000 0,02309745 0,02882481 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,02309745 0,02880918 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,02309745 0,02879357 ! embryonic organ development GO:0048568 45 34 0,000 0,02309745 0,02877797 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,02309745 0,02876239 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,02376932 0,02958303 ! Notch signaling pathway GO:0007219 56 35 0,000 0,02376932 0,02956703 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,02376932 0,02955105 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,02376932 0,02953508 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,02376932 0,02951914 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,02376932 0,02950321 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,02376932 0,02948729 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,02376932 0,0294714 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,02376932 0,02945552 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,02376932 0,02943966 ! pigment metabolic process GO:0042440 61 35 0,000 0,02376932 0,02942381 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,02376932 0,02940798 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,02376932 0,02939217 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,02444077 0,03020622 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,02444077 0,03019 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,02444077 0,03017379 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,02444077 0,0301576 ! negative regulation of binding GO:0051100 58 36 0,000 0,02444077 0,03014143 ! organic ether metabolic process GO:0018904 46 36 0,000 0,02444077 0,03012528 ! tissue remodeling GO:0048771 62 36 0,000 0,02444077 0,03010914 ! neural tube development GO:0021915 50 36 0,000 0,02444077 0,03009303 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,02444077 0,03007692 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,02444077 0,03006084 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,02444077 0,03004477 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,02444077 0,03002872 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,0251118 0,0308367 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,0251118 0,03082024 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,0251118 0,0308038 ! learning GO:0007612 67 37 0,000 0,0251118 0,03078738 ! ion transmembrane transport GO:0034220 56 37 0,000 0,0251118 0,03077098 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,0251118 0,0307546 ! regulation of protein secretion GO:0050708 51 37 0,000 0,0251118 0,03073823 ! amino acid activation GO:0043038 52 37 0,000 0,0251118 0,03072188 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,0251118 0,03070555 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,0257824 0,03150878 ! gliogenesis GO:0042063 71 38 0,000 0,0257824 0,03149204 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,0257824 0,03147533 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,0257824 0,03145863 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,0257824 0,03144195 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,0257824 0,03142529 ! phagocytosis GO:0006909 60 38 0,000 0,0257824 0,03140864 ! mesenchymal cell development GO:0014031 64 38 0,000 0,0257824 0,03139201 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,0257824 0,03137541 ! maintenance of location in cell GO:0051651 69 38 0,000 0,0257824 0,03135881 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,02645258 0,03215694 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,02645258 0,03213995 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,02645258 0,03212298 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,02645258 0,03210603 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,02645258 0,0320891 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,02645258 0,03207218 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,02645258 0,03205528 ! male sex differentiation GO:0046661 53 39 0,000 0,02645258 0,0320384 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,02645258 0,03202154 ! chromatin remodeling GO:0006338 68 39 0,000 0,02645258 0,0320047 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,02645258 0,03198787 ! JNK cascade GO:0007254 54 39 0,000 0,02645258 0,03197106 ! developmental growth GO:0048589 62 39 0,000 0,02645258 0,03195427 ! cell growth GO:0016049 61 39 0,000 0,02645258 0,0319375 ! synapse organization GO:0050808 55 39 0,000 0,02645258 0,03192074 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,02712233 0,03271178 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,02712233 0,03269464 ! regulation of tube size GO:0035150 60 40 0,000 0,02712233 0,03267751 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,02712233 0,0326604 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,02712233 0,03264331 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,02712233 0,03262624 ! peptide metabolic process GO:0006518 56 40 0,000 0,02712233 0,03260918 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,02712233 0,03259215 ! inner ear development GO:0048839 57 40 0,000 0,02712233 0,03257513 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,02712233 0,03255813 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,02712233 0,03254114 ! B cell differentiation GO:0030183 62 40 0,000 0,02712233 0,03252418 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,02712233 0,03250723 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,02712233 0,0324903 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,02712233 0,03247338 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,02779167 0,03325746 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,02779167 0,03324017 ! glucose transport GO:0015758 52 41 0,000 0,02779167 0,03322289 ! endosome transport GO:0016197 71 41 0,000 0,02779167 0,03320563 ! striated muscle contraction GO:0006941 62 41 0,000 0,02779167 0,03318839 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,02779167 0,03317117 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,02779167 0,03315396 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,02779167 0,03313677 ! biopolymer methylation GO:0043414 62 41 0,000 0,02779167 0,03311961 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,02779167 0,03310245 ! mitochondrial transport GO:0006839 60 42 0,000 0,02846058 0,03388164 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,02846058 0,03386412 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,02846058 0,03384661 ! cellular component disassembly GO:0022411 64 42 0,000 0,02846058 0,03382911 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,02846058 0,03381164 ! hexose transport GO:0008645 54 42 0,000 0,02846058 0,03379419 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,02846058 0,03377675 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,02846058 0,03375933 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,02846058 0,03374193 ! excretion GO:0007588 63 42 0,000 0,02846058 0,03372454 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,02846058 0,03370718 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,02846058 0,03368983 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,02846058 0,0336725 ! regulation of cell shape GO:0008360 78 42 0,000 0,02846058 0,03365519 ! positive regulation of binding GO:0051099 59 43 0,000 0,02912907 0,03442799 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,02912907 0,03441031 ! leukocyte migration GO:0050900 60 43 0,000 0,02912907 0,03439264 ! neuromuscular process GO:0050905 79 43 0,000 0,02912907 0,034375 ! activation of caspase activity GO:0006919 65 43 0,000 0,02912907 0,03435737 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,02912907 0,03433976 ! tRNA processing GO:0008033 49 43 0,000 0,02912907 0,03432216 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,02912907 0,03430459 ! vesicle organization GO:0016050 79 43 0,000 0,02912907 0,03428703 ! response to insulin stimulus GO:0032868 63 43 0,000 0,02912907 0,0342695 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,02912907 0,03425198 ! methylation GO:0032259 64 43 0,000 0,02912907 0,03423447 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,02979714 0,03500175 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,02979714 0,03498388 ! glycolysis GO:0006096 53 44 0,000 0,02979714 0,03496603 ! regulation of action potential GO:0001508 71 44 0,000 0,02979714 0,0349482 ! regulation of ion transport GO:0043269 57 44 0,000 0,02979714 0,03493039 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,02979714 0,03491259 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,02979714 0,03489482 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,02979714 0,03487706 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,02979714 0,03485932 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,02979714 0,0348416 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,02979714 0,03482389 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,02979714 0,03480621 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,02979714 0,03478854 ! RNA catabolic process GO:0006401 64 45 0,000 0,03046479 0,03554998 ! positive regulation of defense response GO:0031349 59 45 0,000 0,03046479 0,03553195 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,03046479 0,03551394 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,03046479 0,03549595 ! cell recognition GO:0008037 58 45 0,000 0,03046479 0,03547798 ! cell maturation GO:0048469 60 45 0,000 0,03046479 0,03546003 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,03046479 0,03544209 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,03113201 0,03620002 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,03113201 0,03618172 ! cell redox homeostasis GO:0045454 63 46 0,000 0,03113201 0,03616345 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,03113201 0,0361452 ! regulation of ossification GO:0030278 71 46 0,000 0,03113201 0,03612696 ! histone modification GO:0016570 68 46 0,000 0,03113201 0,03610874 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,03113201 0,03609054 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,03179882 0,03684498 ! viral infectious cycle GO:0019058 71 47 0,000 0,03179882 0,03682643 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,03179882 0,03680789 ! endocrine system development GO:0035270 83 47 0,000 0,03179882 0,03678938 ! covalent chromatin modification GO:0016569 75 47 0,000 0,03179882 0,03677088 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,03179882 0,0367524 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,03179882 0,03673395 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,03179882 0,0367155 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,03179882 0,03669708 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,03179882 0,03667868 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,03179882 0,03666029 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,03179882 0,03664193 ! chloride transport GO:0006821 67 48 0,000 0,0324652 0,03739107 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,0324652 0,03737236 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,0324652 0,03735366 ! response to temperature stimulus GO:0009266 62 48 0,000 0,0324652 0,03733498 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,0324652 0,03731633 ! gastrulation GO:0007369 73 48 0,000 0,0324652 0,03729769 ! heart morphogenesis GO:0003007 65 48 0,000 0,0324652 0,03727907 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,0324652 0,03726046 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,0324652 0,03724188 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,0324652 0,03722331 ! regulation of endocytosis GO:0030100 63 48 0,000 0,0324652 0,03720477 ! nuclear export GO:0051168 69 48 0,000 0,0324652 0,03718624 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,0324652 0,03716773 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,0324652 0,03714924 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,03313117 0,03789243 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,03313117 0,0378736 ! sensory perception of smell GO:0007608 61 49 0,000 0,03313117 0,03785479 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,03313117 0,03783599 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,03313117 0,03781721 ! RNA elongation GO:0006354 62 49 0,000 0,03313117 0,03779846 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,03313117 0,03777972 ! germ cell development GO:0007281 68 49 0,000 0,03313117 0,03776099 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,03313117 0,03774229 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,03313117 0,03772361 ! cartilage development GO:0051216 70 49 0,000 0,03313117 0,03770494 ! maintenance of location GO:0051235 84 49 0,000 0,03313117 0,03768629 ! regulation of actin filament length GO:0030832 72 50 0,000 0,03379671 0,03842434 ! ear development GO:0043583 72 50 0,000 0,03379671 0,03840535 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,03379671 0,03838639 ! membrane fusion GO:0006944 80 50 0,000 0,03379671 0,03836744 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,03379671 0,03834851 ! lipid modification GO:0030258 73 50 0,000 0,03379671 0,0383296 ! positive regulation of growth GO:0045927 67 50 0,000 0,03379671 0,03831071 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,03379671 0,03829184 ! proton transport GO:0015992 75 50 0,000 0,03379671 0,03827299 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,03379671 0,03825415 ! positive regulation of secretion GO:0051047 71 51 0,000 0,03446184 0,03898781 ! hydrogen transport GO:0006818 77 51 0,000 0,03446184 0,03896864 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,03446184 0,03894949 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,03446184 0,03893036 ! positive regulation of cell migration GO:0030335 92 51 0,000 0,03446184 0,03891125 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,03446184 0,03889216 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,03446184 0,03887309 ! adult behavior GO:0030534 80 51 0,000 0,03446184 0,03885403 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,03446184 0,03883499 ! transition metal ion transport GO:0000041 74 52 0,000 0,03512654 0,03956466 ! regulation of cellular component size GO:0032535 74 52 0,000 0,03512654 0,0395453 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,03512654 0,03952595 ! aging GO:0007568 79 52 0,000 0,03512654 0,03950662 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,03512654 0,03948731 ! establishment of organelle localization GO:0051656 85 52 0,000 0,03512654 0,03946802 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,03579082 0,04019477 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,03579082 0,04017516 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,03579082 0,04015556 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,03579082 0,04013598 ! kidney development GO:0001822 90 53 0,000 0,03579082 0,04011642 ! single fertilization GO:0007338 59 53 0,000 0,03579082 0,04009688 ! cell projection assembly GO:0030031 76 53 0,000 0,03579082 0,04007736 ! amino acid transport GO:0006865 84 54 0,000 0,03645469 0,04080087 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,03645469 0,04078102 ! regulation of mitosis GO:0007088 84 54 0,000 0,03645469 0,0407612 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,03645469 0,04074139 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,03645469 0,04072161 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,03645469 0,04070184 ! DNA catabolic process GO:0006308 67 54 0,000 0,03645469 0,04068209 ! detection of external stimulus GO:0009581 66 54 0,000 0,03645469 0,04066236 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,03645469 0,04064265 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,03645469 0,04062296 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,03645469 0,04060329 ! exocytosis GO:0006887 74 55 0,000 0,03711814 0,04132222 ! mesoderm development GO:0007498 76 55 0,000 0,03711814 0,04130223 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,03711814 0,04128226 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,03711814 0,04126231 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,03778116 0,04197907 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,03778116 0,0419588 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,03778116 0,04193855 ! positive regulation of cell motion GO:0051272 99 56 0,000 0,03778116 0,04191832 ! negative regulation of protein kinase activity GO:0006469 99 57 0,000 0,03844377 0,04263292 ! carbohydrate transport GO:0008643 74 57 0,000 0,03844377 0,04261237 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,03844377 0,04259185 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,03844377 0,04257134 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,03844377 0,04255086 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,03844377 0,04253039 ! camera-type eye development GO:0043010 88 57 0,000 0,03844377 0,04250994 ! secondary metabolic process GO:0019748 84 57 0,000 0,03844377 0,04248951 ! response to peptide hormone stimulus GO:0043434 84 57 0,000 0,03844377 0,04246911 ! developmental maturation GO:0021700 75 57 0,000 0,03844377 0,04244872 ! gonad development GO:0008406 79 57 0,000 0,03844377 0,04242835 ! negative regulation of kinase activity GO:0033673 100 58 0,000 0,03910596 0,04313847 ! viral reproductive process GO:0022415 87 58 0,000 0,03910596 0,04311779 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,03910596 0,04309713 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,03910596 0,04307649 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,03910596 0,04305587 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,03976774 0,04376354 ! activation of MAPK activity GO:0000187 84 59 0,000 0,03976774 0,04374261 ! lung development GO:0030324 94 59 0,000 0,03976774 0,0437217 ! actin filament organization GO:0007015 95 59 0,000 0,03976774 0,04370081 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,03976774 0,04367994 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,03976774 0,04365909 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,04042909 0,04436398 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,04042909 0,04434283 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,04042909 0,04432169 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,04042909 0,04430058 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,04042909 0,04427948 ! regulation of heart contraction GO:0008016 91 60 0,000 0,04042909 0,04425841 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,04042909 0,04423735 ! fertilization GO:0009566 68 60 0,000 0,04042909 0,04421631 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,04042909 0,0441953 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,04109003 0,04489647 ! meiosis GO:0007126 96 61 0,000 0,04109003 0,04487515 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,04109003 0,04485385 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,04109003 0,04483257 ! urogenital system development GO:0001655 101 61 0,000 0,04109003 0,04481132 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,04109003 0,04479008 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,04109003 0,04476886 ! extracellular matrix organization GO:0030198 103 61 0,000 0,04109003 0,04474766 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,04109003 0,04472649 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 0,000 0,04109003 0,04470533 ! amine catabolic process GO:0009310 90 62 0,000 0,04175055 0,04540249 ! neurotransmitter transport GO:0006836 81 62 0,000 0,04175055 0,04538103 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,04175055 0,04535959 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,04175055 0,04533818 ! respiratory tube development GO:0030323 99 62 0,000 0,04175055 0,04531678 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,04175055 0,04529541 ! meiotic cell cycle GO:0051321 97 62 0,000 0,04175055 0,04527405 ! organelle localization GO:0051640 96 62 0,000 0,04175055 0,04525272 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,04241065 0,04594654 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,04241065 0,04592491 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,04241065 0,04590329 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,04241065 0,0458817 ! viral reproduction GO:0016032 92 63 0,000 0,04241065 0,04586013 ! regulation of lipase activity GO:0060191 109 63 0,000 0,04241065 0,04583858 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,04307034 0,04652972 ! negative regulation of cell size GO:0045792 108 64 0,000 0,04307034 0,04650788 ! appendage morphogenesis GO:0035107 93 64 0,000 0,04307034 0,04648605 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,04307034 0,04646425 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,04307034 0,04644246 ! hexose catabolic process GO:0019320 82 64 0,000 0,04307034 0,0464207 ! respiratory system development GO:0060541 100 64 0,000 0,04307034 0,04639896 ! adaptive immune response GO:0002250 94 64 0,000 0,04307034 0,04637724 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,04372961 0,04706509 ! regulation of caspase activity GO:0043281 97 65 0,000 0,04372961 0,04704308 ! appendage development GO:0048736 94 65 0,000 0,04372961 0,04702108 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,04372961 0,04699911 ! defense response to bacterium GO:0042742 73 65 0,000 0,04372961 0,04697716 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,04372961 0,04695523 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,04372961 0,04693332 ! activation of immune response GO:0002253 83 65 0,000 0,04372961 0,04691143 ! protein oligomerization GO:0051259 100 65 0,000 0,04372961 0,04688956 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,04438846 0,04757384 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,04438846 0,04755168 ! antigen processing and presentation GO:0019882 96 66 0,000 0,04438846 0,04752954 ! axon guidance GO:0007411 99 66 0,000 0,04438846 0,04750743 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,04438846 0,04748533 ! regulation of immune effector process GO:0002697 101 66 0,000 0,04438846 0,04746325 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,0450469 0,04814492 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,0450469 0,04812256 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,0450469 0,04810022 ! acute inflammatory response GO:0002526 92 68 0,000 0,04570492 0,04878019 ! learning or memory GO:0007611 123 68 0,000 0,04570492 0,04875757 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,04570492 0,04873496 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,04570492 0,04871238 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,04570492 0,04868982 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,04570492 0,04866727 ! rhythmic process GO:0048511 105 68 0,000 0,04570492 0,04864475 ! inorganic anion transport GO:0015698 93 68 0,000 0,04570492 0,04862225 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,04636252 0,04929903 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,04636252 0,04927625 ! response to drug GO:0042493 108 69 0,000 0,04636252 0,04925349 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,04701971 0,0499286 ! humoral immune response GO:0006959 86 70 0,000 0,04701971 0,04990556 ! eye development GO:0001654 111 70 0,000 0,04701971 0,04988254 ! amine transport GO:0015837 101 70 0,000 0,04701971 0,04985954 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,04701971 0,04983656 ! regulation of catabolic process GO:0009894 106 70 0,000 0,04701971 0,04981361 ! muscle cell differentiation GO:0042692 104 71 0,000 0,04767649 0,05048615 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,04767649 0,05046292 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,04767649 0,05043971 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,04767649 0,05041652 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,04767649 0,05039335 ! regulation of peptidase activity GO:0052547 106 72 0,000 0,04833285 0,05106364 ! response to hypoxia GO:0001666 132 72 0,000 0,04833285 0,0510402 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,04833285 0,05101677 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,04833285 0,05099337 ! negative regulation of transport GO:0051051 116 73 0,000 0,04898879 0,05166173 ! regulation of blood pressure GO:0008217 107 73 0,000 0,04898879 0,05163805 ! tube morphogenesis GO:0035239 118 73 0,000 0,04898879 0,0516144 ! mitochondrion organization GO:0007005 104 73 0,000 0,04898879 0,05159076 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,04898879 0,05156715 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,04898879 0,05154356 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,04964432 0,05220939 ! response to oxygen levels GO:0070482 137 74 0,000 0,04964432 0,05218553 ! digestion GO:0007586 97 74 0,000 0,04964432 0,05216169 ! protein import into nucleus GO:0006606 118 74 0,000 0,04964432 0,05213788 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,04964432 0,05211408 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,04964432 0,0520903 ! blood coagulation GO:0007596 116 75 0,000 0,05029944 0,05275363 GO:0050817|coagulation, ! negative regulation of growth GO:0045926 123 75 0,000 0,05029944 0,05272959 ! response to nutrient GO:0007584 104 75 0,000 0,05029944 0,05270556 ! nuclear import GO:0051170 121 75 0,000 0,05029944 0,05268156 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,05029944 0,05265759 ! amine biosynthetic process GO:0009309 97 76 0,000 0,05095414 0,05331871 ! tRNA metabolic process GO:0006399 95 76 0,000 0,05095414 0,05329447 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,05095414 0,05327024 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,05160843 0,05392976 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,05160843 0,05390527 ! regulation of DNA binding GO:0051101 119 77 0,000 0,05160843 0,0538808 ! gland development GO:0048732 148 77 0,000 0,05160843 0,05385635 ! sex differentiation GO:0007548 105 77 0,000 0,05160843 0,05383193 ! protein ubiquitination GO:0016567 125 77 0,000 0,05160843 0,05380752 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,05160843 0,05378314 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,05160843 0,05375878 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,05160843 0,05373445 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,05226231 0,05439064 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,05226231 0,05436604 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,05291577 0,05502092 ! cellular respiration GO:0045333 107 79 0,000 0,05291577 0,05499606 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,05291577 0,05497122 ! T cell activation GO:0042110 134 79 0,000 0,05291577 0,0549464 ! regulation of lyase activity GO:0051339 133 79 0,000 0,05291577 0,0549216 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,05291577 0,05489683 ! chromatin assembly GO:0031497 102 80 0,000 0,05356882 0,05554927 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,05356882 0,05552424 ! protein localization in nucleus GO:0034504 133 80 0,000 0,05356882 0,05549923 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,05356882 0,05547424 ! forebrain development GO:0030900 131 80 0,000 0,05356882 0,05544927 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,05422145 0,05609957 ! hemostasis GO:0007599 125 81 0,000 0,05422145 0,05607435 ! mRNA transport GO:0051028 121 81 0,000 0,05422145 0,05604914 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,05422145 0,05602397 ! regulation of neurological system process GO:0031644 122 81 0,000 0,05422145 0,05599881 ! vitamin metabolic process GO:0006766 103 81 0,000 0,05422145 0,05597367 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,05422145 0,05594856 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,05487368 0,05659617 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,05487368 0,0565708 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,05552549 0,05721713 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,05552549 0,0571915 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,05552549 0,0571659 ! regulation of defense response GO:0031347 117 84 0,000 0,05617689 0,05781067 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,05617689 0,05778481 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,05617689 0,05775898 ! sterol metabolic process GO:0016125 120 84 0,000 0,05617689 0,05773317 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,05682788 0,05837611 ! rRNA metabolic process GO:0016072 107 85 0,000 0,05682788 0,05835005 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 0,000 0,05682788 0,05832401 ! transcription initiation GO:0006352 118 85 0,000 0,05682788 0,058298 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,05682788 0,05827201 ! regulation of membrane potential GO:0042391 128 85 0,000 0,05682788 0,05824604 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,05682788 0,0582201 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,05747845 0,05886039 ! cell cycle arrest GO:0007050 150 86 0,000 0,05747845 0,0588342 ! nucleosome organization GO:0034728 114 87 0,000 0,05812862 0,05947323 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,05812862 0,05944678 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,05812862 0,05942036 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,05812862 0,05939397 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,05812862 0,05936759 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,05877837 0,06000455 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,05877837 0,05997793 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,05877837 0,05995133 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,05877837 0,05992476 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,05877837 0,05989821 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,05942771 0,0605331 ! reproductive developmental process GO:0003006 127 89 0,000 0,05942771 0,0605063 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,05942771 0,06047953 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,05942771 0,06045278 ! regulation of T cell activation GO:0050863 128 89 0,000 0,05942771 0,06042606 ! leukocyte differentiation GO:0002521 143 90 0,000 0,06007664 0,0610589 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,06007664 0,06103193 ! hormone metabolic process GO:0042445 121 90 0,000 0,06007664 0,06100498 ! RNA localization GO:0006403 135 91 0,000 0,06072516 0,06163631 ! ATP metabolic process GO:0046034 137 91 0,000 0,06072516 0,06160912 ! response to virus GO:0009615 122 91 0,000 0,06072516 0,06158196 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,06137328 0,06221178 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,06137328 0,06218438 ! cell fate commitment GO:0045165 141 92 0,000 0,06137328 0,06215699 ! positive regulation of immune response GO:0050778 121 92 0,000 0,06137328 0,06212964 ! DNA recombination GO:0006310 146 92 0,000 0,06137328 0,0621023 ! sulfur metabolic process GO:0006790 118 92 0,000 0,06137328 0,06207499 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,06202098 0,06270253 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,06202098 0,06267498 ! electron transport chain GO:0022900 123 94 0,000 0,06266827 0,06330128 ! response to oxidative stress GO:0006979 141 94 0,000 0,06266827 0,06327349 ! regulation of binding GO:0051098 151 95 0,000 0,06331515 0,06389857 ! angiogenesis GO:0001525 149 95 0,000 0,06331515 0,06387055 ! carboxylic acid transport GO:0046942 147 95 0,000 0,06331515 0,06384254 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,06396162 0,06446614 ! in utero embryonic development GO:0001701 147 96 0,000 0,06396162 0,0644379 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,06396162 0,06440969 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,06396162 0,0643815 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,06396162 0,06435334 ! protein maturation GO:0051604 129 96 0,000 0,06396162 0,0643252 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,06460769 0,06494654 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,06460769 0,06491816 ! calcium ion transport GO:0006816 167 99 0,000 0,06589859 0,06618635 ! extracellular structure organization GO:0043062 156 99 0,000 0,06589859 0,06615746 ! protein import GO:0017038 156 99 0,000 0,06589859 0,0661286 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,06589859 0,06609976 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,06654342 0,06671747 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,06654342 0,0666884 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,06654342 0,06665935 ! divalent metal ion transport GO:0070838 171 100 0,000 0,06654342 0,06663033 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,06654342 0,06660134 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,06654342 0,06657237 ! protein localization in organelle GO:0033365 161 100 0,000 0,06654342 0,06654342