pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a2/out-0.05-06-0.01-300-run-a2//th1-pval-1e-01-11-th2-pval-1e-02-02-th3-pval-1e-01-02-run-a2/go_data/7465-9-real-Parker_GPL887-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/GPL887.an.zip classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 55 51 3,000 3,392E-09 1,238E-05 ! G1/S transition of mitotic cell cycle GO:0000082 54 43 2,000 6,271E-07 1,144E-03 ! positive regulation of cell-matrix adhesion GO:0001954 8 5 1,000 1,597E-06 1,942E-03 GO:0010811|positive regulation of cell-substrate adhesion, ! RNA polymerase II carboxy-terminal domain kinase activity GO:0008353 5 5 1,000 1,597E-06 1,457E-03 ! protein kinase regulator activity GO:0019887 74 66 2,000 2,315E-06 1,689E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 6 6 1,000 2,395E-06 1,456E-03 ! regulation of focal adhesion formation GO:0051893 6 6 1,000 2,395E-06 1,248E-03 ! negative regulation of protein ubiquitination GO:0031397 7 6 1,000 2,395E-06 1,092E-03 ! kinase regulator activity GO:0019207 93 76 2,000 3,549E-06 1,438E-03 ! interphase of mitotic cell cycle GO:0051329 100 81 2,000 4,303E-06 1,57E-03 ! cyclin-dependent protein kinase holoenzyme complex GO:0000307 8 8 1,000 4,469E-06 1,482E-03 ! keratinocyte proliferation GO:0043616 9 8 1,000 4,469E-06 1,359E-03 ! positive regulation of Rho GTPase activity GO:0032321 11 8 1,000 4,469E-06 1,254E-03 ! regulation of actin filament bundle formation GO:0032231 13 8 1,000 4,469E-06 1,164E-03 GO:0051492|regulation of stress fiber formation, ! interphase GO:0051325 103 83 2,000 4,632E-06 1,126E-03 ! regulation of phosphoprotein phosphatase activity GO:0043666 9 9 1,000 5,745E-06 1,31E-03 ! regulation of cytoskeleton organization GO:0051493 133 93 2,000 6,528E-06 1,401E-03 ! positive regulation of Ras GTPase activity GO:0032320 14 10 1,000 7,179E-06 1,455E-03 ! regulation of phosphatase activity GO:0010921 10 10 1,000 7,179E-06 1,378E-03 ! negative regulation of caspase activity GO:0043154 12 11 1,000 8,773E-06 1,6E-03 ! positive regulation of GTPase activity GO:0043547 17 12 1,000 1,052E-05 1,828E-03 ! midbody GO:0030496 14 12 1,000 1,052E-05 1,745E-03 ! negative regulation of peptidase activity GO:0010466 16 14 1,000 1,451E-05 2,301E-03 ! positive regulation of cell growth GO:0030307 15 14 1,000 1,451E-05 2,205E-03 ! negative regulation of microtubule depolymerization GO:0007026 16 14 1,000 1,451E-05 2,117E-03 GO:0031114|regulation of microtubule depolymerization, ! release of cytochrome c from mitochondria GO:0001836 26 14 1,000 1,451E-05 2,035E-03 ! cyclin-dependent protein kinase regulator activity GO:0016538 14 14 1,000 1,451E-05 1,96E-03 ! regulation of Rho GTPase activity GO:0032319 18 15 1,000 1,673E-05 2,18E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 17 15 1,000 1,673E-05 2,105E-03 ! protein serine/threonine kinase inhibitor activity GO:0030291 17 16 1,000 1,912E-05 2,325E-03 ! regulation of protein ubiquitination GO:0031396 27 16 1,000 1,912E-05 2,25E-03 ! skin development GO:0043588 20 17 1,000 2,166E-05 2,47E-03 ! regulation of dephosphorylation GO:0035303 20 17 1,000 2,166E-05 2,395E-03 ! positive regulation of cell size GO:0045793 19 18 1,000 2,437E-05 2,614E-03 ! negative regulation of translation GO:0017148 31 18 1,000 2,437E-05 2,54E-03 ! spindle microtubule GO:0005876 27 18 1,000 2,437E-05 2,469E-03 ! cellular response to unfolded protein GO:0034620 21 19 1,000 2,723E-05 2,685E-03 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of microtubule polymerization or depolymerization GO:0031110 21 19 1,000 2,723E-05 2,614E-03 ! chaperone binding GO:0051087 21 20 1,000 3,025E-05 2,829E-03 ! regulation of cell-matrix adhesion GO:0001952 26 20 1,000 3,025E-05 2,759E-03 GO:0010810|regulation of cell-substrate adhesion, ! apoptotic mitochondrial changes GO:0008637 33 21 1,000 3,342E-05 2,974E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 33 22 1,000 3,676E-05 3,193E-03 ! actin filament GO:0005884 26 24 1,000 4,39E-05 3,724E-03 ! regulation of microtubule cytoskeleton organization GO:0070507 35 24 1,000 4,39E-05 3,64E-03 ! positive regulation of cell adhesion GO:0045785 34 26 1,000 5,167E-05 4,189E-03 ! response to endoplasmic reticulum stress GO:0034976 30 26 1,000 5,167E-05 4,098E-03 ! RNA export from nucleus GO:0006405 31 27 1,000 5,579E-05 4,331E-03 ! fat cell differentiation GO:0045444 30 27 1,000 5,579E-05 4,24E-03 ! cyclin-dependent protein kinase activity GO:0004693 28 27 1,000 5,579E-05 4,154E-03 ! ER-nuclear signaling pathway GO:0006984 32 29 1,000 6,451E-05 4,707E-03 ! negative regulation of protein modification process GO:0031400 34 30 1,000 6,91E-05 4,943E-03 ! regulation of microtubule-based process GO:0032886 41 30 1,000 6,91E-05 4,848E-03 ! response to calcium ion GO:0051592 34 31 1,000 7,385E-05 5,083E-03 ! negative regulation of hydrolase activity GO:0051346 36 34 1,000 8,904E-05 6,015E-03 ! protein kinase inhibitor activity GO:0004860 37 34 1,000 8,904E-05 5,906E-03 ! kinase inhibitor activity GO:0019210 47 35 1,000 9,442E-05 6,151E-03 ! protein tyrosine/serine/threonine phosphatase activity GO:0008138 44 36 1,000 9,995E-05 6,397E-03 ! negative regulation of protein complex disassembly GO:0043242 42 38 1,000 1,115E-04 7,012E-03 ! non-membrane spanning protein tyrosine kinase activity GO:0004715 52 38 1,000 1,115E-04 6,893E-03 ! induction of apoptosis by intracellular signals GO:0008629 56 41 1,000 1,3E-04 7,901E-03 ! lamellipodium GO:0030027 56 41 1,000 1,3E-04 7,772E-03 ! nuclear export GO:0051168 46 42 1,000 1,364E-04 8,027E-03 ! protein serine/threonine phosphatase activity GO:0004722 45 42 1,000 1,364E-04 7,9E-03 ! positive regulation of cell cycle GO:0045787 56 43 1,000 1,43E-04 8,154E-03 ! positive regulation of growth GO:0045927 47 43 1,000 1,43E-04 8,028E-03 ! regulation of protein complex disassembly GO:0043244 49 45 1,000 1,568E-04 8,665E-03 ! response to UV GO:0009411 59 45 1,000 1,568E-04 8,535E-03 ! response to insulin stimulus GO:0032868 57 47 1,000 1,711E-04 9,179E-03 ! protein N-terminus binding GO:0047485 57 48 1,000 1,785E-04 9,437E-03 ! negative regulation of cytoskeleton organization GO:0051494 73 49 1,000 1,861E-04 9,696E-03 ! DNA damage response, signal transduction GO:0042770 84 50 1,000 1,938E-04 9,956E-03 ! keratinocyte differentiation GO:0030216 60 53 1,000 2,178E-04 0,01103661 ! epidermal cell differentiation GO:0009913 66 58 1,000 2,61E-04 0,01304382 ! response to metal ion GO:0010038 65 60 1,000 2,794E-04 0,01377243 ! regulation of caspase activity GO:0043281 78 60 1,000 2,794E-04 0,01358879 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 77 62 1,000 2,983E-04 0,01432059 ! positive regulation of protein amino acid phosphorylation GO:0001934 72 62 1,000 2,983E-04 0,01413461 ! regulation of endopeptidase activity GO:0052548 81 63 1,000 3,081E-04 0,01440781 ! negative regulation of protein kinase activity GO:0006469 78 64 1,000 3,179E-04 0,01468117 ! regulation of actin cytoskeleton organization GO:0032956 93 64 1,000 3,179E-04 0,01449766 ! response to unfolded protein GO:0006986 66 64 1,000 3,179E-04 0,01431868 ! response to inorganic substance GO:0010035 71 65 1,000 3,28E-04 0,01458995 ! negative regulation of kinase activity GO:0033673 79 65 1,000 3,28E-04 0,01441417 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 80 65 1,000 3,28E-04 0,01424257 ! regulation of peptidase activity GO:0052547 86 67 1,000 3,485E-04 0,01495507 ! response to peptide hormone stimulus GO:0043434 79 67 1,000 3,485E-04 0,01478117 ! regulation of actin filament-based process GO:0032970 96 67 1,000 3,485E-04 0,01461128 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 83 67 1,000 3,485E-04 0,01444524 ! negative regulation of organelle organization GO:0010639 93 68 1,000 3,589E-04 0,0147126 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 84 68 1,000 3,589E-04 0,01454913 ! positive regulation of ligase activity GO:0051351 86 70 1,000 3,804E-04 0,0152481 ! negative regulation of transferase activity GO:0051348 85 70 1,000 3,804E-04 0,01508236 ! positive regulation of phosphorylation GO:0042327 82 70 1,000 3,804E-04 0,01492018 ! response to protein stimulus GO:0051789 73 70 1,000 3,804E-04 0,01476146 ! cell cortex GO:0005938 77 70 1,000 3,804E-04 0,01460607 ! positive regulation of phosphorus metabolic process GO:0010562 85 72 1,000 4,024E-04 0,01529128 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of Rho protein signal transduction GO:0035023 88 73 1,000 4,136E-04 0,01555661 ! regulation of ubiquitin-protein ligase activity GO:0051438 92 75 1,000 4,366E-04 0,01625221 ! cell leading edge GO:0031252 97 76 1,000 4,483E-04 0,01651932 ! regulation of Ras GTPase activity GO:0032318 88 77 1,000 4,602E-04 0,01678665 ! establishment of RNA localization GO:0051236 97 77 1,000 4,602E-04 0,01662044 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! regulation of ligase activity GO:0051340 95 78 1,000 4,722E-04 0,01688698 ! positive regulation of protein modification process GO:0031401 100 78 1,000 4,722E-04 0,01672302 ! RNA localization GO:0006403 99 79 1,000 4,843E-04 0,01698878 ! mitochondrion organization GO:0007005 104 82 1,000 5,217E-04 0,01812611 ! regulation of cell adhesion GO:0030155 98 83 1,000 5,345E-04 0,01839451 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 101 83 1,000 5,345E-04 0,0182226 GO:0010498|proteasomal protein catabolic process, ! protein tyrosine phosphatase activity GO:0004725 109 89 1,000 6,143E-04 0,02074883 ! protein kinase binding GO:0019901 115 89 1,000 6,143E-04 0,02055847 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 112 91 1,000 6,421E-04 0,02129364 ! spindle GO:0005819 126 92 1,000 6,562E-04 0,02156612 ! regulation of cellular component biogenesis GO:0044087 115 92 1,000 6,562E-04 0,02137357 ! regulation of GTPase activity GO:0043087 105 92 1,000 6,562E-04 0,02118442 ! cell cycle arrest GO:0007050 103 93 1,000 6,705E-04 0,02145551 ! microtubule associated complex GO:0005875 135 97 1,000 7,291E-04 0,02312844 ! perinuclear region of cytoplasm GO:0048471 125 97 1,000 7,291E-04 0,02292906 ! negative regulation of cellular component organization GO:0051129 132 99 1,000 7,593E-04 0,02367504 ! response to light stimulus GO:0009416 131 100 1,000 7,746E-04 0,02394835 ! positive regulation of epidermal growth factor receptor activity GO:0045741 6 5 0,000 2,135E-03 0,06545415 ! negative regulation of S phase of mitotic cell cycle GO:0045749 5 5 0,000 2,135E-03 0,0649087 ! positive regulation of fatty acid biosynthetic process GO:0045723 5 5 0,000 2,135E-03 0,06437226 ! positive regulation of tumor necrosis factor biosynthetic process GO:0042535 6 5 0,000 2,135E-03 0,06384462 ! response to superoxide GO:0000303 5 5 0,000 2,135E-03 0,06332556 ! negative regulation of small GTPase mediated signal transduction GO:0051058 6 5 0,000 2,135E-03 0,06281487 GO:0046580|negative regulation of Ras protein signal transduction, ! regulation of interferon-alpha production GO:0032647 6 5 0,000 2,135E-03 0,06231235 GO:0032479|regulation of type I interferon production, ! regulation of hormone biosynthetic process GO:0046885 5 5 0,000 2,135E-03 0,06181781 ! calcium:cation antiporter activity GO:0015368 5 5 0,000 2,135E-03 0,06133105 ! quinolinate metabolic process GO:0046874 5 5 0,000 2,135E-03 0,06085191 ! biotin binding GO:0009374 7 5 0,000 2,135E-03 0,06038018 ! secondary active monocarboxylate transmembrane transporter activity GO:0015355 6 5 0,000 2,135E-03 0,05991572 ! tongue development GO:0043586 6 5 0,000 2,135E-03 0,05945835 ! nose development GO:0043584 5 5 0,000 2,135E-03 0,05900791 ! cell proliferation in forebrain GO:0021846 5 5 0,000 2,135E-03 0,05856424 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 5 5 0,000 2,135E-03 0,05812719 ! sodium-dependent phosphate transmembrane transporter activity GO:0015321 6 5 0,000 2,135E-03 0,05769662 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 7 5 0,000 2,135E-03 0,05727238 ! drug:hydrogen antiporter activity GO:0015307 6 5 0,000 2,135E-03 0,05685433 GO:0015520|tetracycline:hydrogen antiporter activity, GO:0015904|tetracycline transport, ! nuclear mRNA 3'-splice site recognition GO:0000389 6 5 0,000 2,135E-03 0,05644235 ! glycolipid transport GO:0046836 6 5 0,000 2,135E-03 0,05603629 ! phospholipid:diacylglycerol acyltransferase activity GO:0046027 6 5 0,000 2,135E-03 0,05563603 ! regulation of respiratory gaseous exchange GO:0043576 6 5 0,000 2,135E-03 0,05524145 ! regulation of protein export from nucleus GO:0046825 5 5 0,000 2,135E-03 0,05485242 ! neuron adhesion GO:0007158 5 5 0,000 2,135E-03 0,05446884 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 5 5 0,000 2,135E-03 0,05409058 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GO:0046912 6 5 0,000 2,135E-03 0,05371754 ! opioid peptide activity GO:0001515 6 5 0,000 2,135E-03 0,05334962 ! selenocysteine incorporation GO:0001514 5 5 0,000 2,135E-03 0,05298669 GO:0006451|translational readthrough, ! mRNA stabilization GO:0048255 6 5 0,000 2,135E-03 0,05262867 GO:0043489|RNA stabilization, ! N-acetylglucosamine 6-O-sulfotransferase activity GO:0001517 8 5 0,000 2,135E-03 0,05227546 ! cardiac muscle cell proliferation GO:0060038 6 5 0,000 2,135E-03 0,05192696 GO:0014855|striated muscle cell proliferation, ! dsRNA fragmentation GO:0031050 6 5 0,000 2,135E-03 0,05158307 GO:0035196|gene silencing by miRNA, production of miRNAs, GO:0035195|gene silencing by miRNA, ! ruffle membrane GO:0032587 6 5 0,000 2,135E-03 0,05124371 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 2,135E-03 0,05090878 ! negative regulation of receptor-mediated endocytosis GO:0048261 7 5 0,000 2,135E-03 0,05057821 ! clathrin coat assembly GO:0048268 6 5 0,000 2,135E-03 0,0502519 ! cerebral cortex cell migration GO:0021795 5 5 0,000 2,135E-03 0,04992977 ! eukaryotic translation elongation factor 1 complex GO:0005853 5 5 0,000 2,135E-03 0,04961174 ! membrane hyperpolarization GO:0060081 5 5 0,000 2,135E-03 0,04929775 ! regulation of striated muscle cell differentiation GO:0051153 6 5 0,000 2,135E-03 0,0489877 ! regulation of smooth muscle cell differentiation GO:0051150 5 5 0,000 2,135E-03 0,04868152 ! translation repressor activity GO:0030371 8 5 0,000 2,135E-03 0,04837915 ! positive regulation of muscle cell differentiation GO:0051149 6 5 0,000 2,135E-03 0,04808052 ! smooth muscle cell differentiation GO:0051145 6 5 0,000 2,135E-03 0,04778555 ! chaperone-mediated protein complex assembly GO:0051131 5 5 0,000 2,135E-03 0,04749417 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 5 5 0,000 2,135E-03 0,04720633 ! negative regulation of stress-activated protein kinase signaling pathway GO:0070303 6 5 0,000 2,135E-03 0,04692195 GO:0046329|negative regulation of JNK cascade, ! double-stranded telomeric DNA binding GO:0003691 6 5 0,000 2,135E-03 0,04664098 ! negative regulation of heart contraction GO:0045822 5 5 0,000 2,135E-03 0,04636336 ! N-acetylgalactosamine 4-O-sulfotransferase activity GO:0001537 5 5 0,000 2,135E-03 0,04608902 ! microfibril GO:0001527 5 5 0,000 2,135E-03 0,04581791 ! troponin I binding GO:0031013 5 5 0,000 2,135E-03 0,04554996 ! negative regulation of viral genome replication GO:0045071 6 5 0,000 2,135E-03 0,04528514 ! traversing start control point of mitotic cell cycle GO:0007089 6 5 0,000 2,135E-03 0,04502337 ! positive regulation of interleukin-12 biosynthetic process GO:0045084 5 5 0,000 2,135E-03 0,04476462 ! dorsal/ventral neural tube patterning GO:0021904 5 5 0,000 2,135E-03 0,04450882 ! dermatan sulfate proteoglycan metabolic process GO:0050655 5 5 0,000 2,135E-03 0,04425593 ! protein lipoylation GO:0009249 14 5 0,000 2,135E-03 0,0440059 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 2,135E-03 0,04375867 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 5 5 0,000 2,135E-03 0,04351421 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! regulation of isotype switching to IgG isotypes GO:0048302 5 5 0,000 2,135E-03 0,04327247 ! transmembrane-ephrin receptor activity GO:0005005 6 5 0,000 2,135E-03 0,04303339 ! mitochondrion localization, microtubule-mediated GO:0034643 5 5 0,000 2,135E-03 0,04279694 GO:0047497|mitochondrion transport along microtubule, GO:0051654|establishment of mitochondrion localization, ! vasopressin receptor activity GO:0005000 5 5 0,000 2,135E-03 0,04256308 ! glutamate catabolic process GO:0006538 6 5 0,000 2,135E-03 0,04233176 ! microvillus organization GO:0032528 5 5 0,000 2,135E-03 0,04210294 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 6 5 0,000 2,135E-03 0,04187658 ! tyrosine catabolic process GO:0006572 5 5 0,000 2,135E-03 0,04165264 ! response to pH GO:0009268 5 5 0,000 2,135E-03 0,04143108 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 6 5 0,000 2,135E-03 0,04121187 ! regulation of protein import into nucleus, translocation GO:0033158 5 5 0,000 2,135E-03 0,04099497 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor GO:0016670 5 5 0,000 2,135E-03 0,04078033 ! polyol biosynthetic process GO:0046173 5 5 0,000 2,135E-03 0,04056794 ! phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 7 5 0,000 2,135E-03 0,04035774 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 2,135E-03 0,04014971 ! fibroblast growth factor receptor activity GO:0005007 6 5 0,000 2,135E-03 0,03994381 ! protein-DNA loading ATPase activity GO:0033170 6 5 0,000 2,135E-03 0,03974002 GO:0003689|DNA clamp loader activity, ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) GO:0000276 5 5 0,000 2,135E-03 0,03953829 ! anaerobic glycolysis GO:0019642 5 5 0,000 2,135E-03 0,03933861 GO:0004459|L-lactate dehydrogenase activity, ! adenosine receptor activity, G-protein coupled GO:0001609 6 5 0,000 2,135E-03 0,03914092 ! regulation of retinoic acid receptor signaling pathway GO:0048385 6 5 0,000 2,135E-03 0,03894522 ! peroxisomal matrix GO:0005782 5 5 0,000 2,135E-03 0,03875146 GO:0031907|microbody lumen, ! regulation of angiotensin levels in blood GO:0002002 5 5 0,000 2,135E-03 0,03855962 GO:0060177|regulation of angiotensin metabolic process, ! vacuolar lumen GO:0005775 6 5 0,000 2,135E-03 0,03836967 ! morphogenesis of an epithelial sheet GO:0002011 5 5 0,000 2,135E-03 0,03818159 ! multivesicular body GO:0005771 5 5 0,000 2,135E-03 0,03799534 ! regulation of phospholipase A2 activity GO:0032429 5 5 0,000 2,135E-03 0,03781089 GO:0032430|positive regulation of phospholipase A2 activity, ! paraxial mesoderm formation GO:0048341 6 5 0,000 2,135E-03 0,03762823 ! insulin-like growth factor I binding GO:0031994 6 5 0,000 2,135E-03 0,03744733 ! mitochondrial outer membrane translocase complex GO:0005742 5 5 0,000 2,135E-03 0,03726815 ! peptidyl-histidine phosphorylation GO:0018106 6 5 0,000 2,135E-03 0,03709069 ! negative regulation of lipoprotein lipase activity GO:0051005 5 5 0,000 2,135E-03 0,0369149 ! epithelial cell maturation GO:0002070 14 5 0,000 2,135E-03 0,03674077 ! positive regulation of lipoprotein lipase activity GO:0051006 6 5 0,000 2,135E-03 0,03656828 ! muscle thin filament assembly GO:0030240 5 5 0,000 2,135E-03 0,0363974 ! regulation of protein amino acid autophosphorylation GO:0031952 5 5 0,000 2,135E-03 0,03622811 ! nitric-oxide synthase regulator activity GO:0030235 6 5 0,000 2,135E-03 0,03606039 ! negative regulation of fatty acid metabolic process GO:0045922 14 5 0,000 2,135E-03 0,03589421 ! regulation of glycoprotein biosynthetic process GO:0010559 6 5 0,000 2,135E-03 0,03572956 ! cellular glucose homeostasis GO:0001678 5 5 0,000 2,135E-03 0,03556641 ! positive regulation of translational initiation GO:0045948 6 5 0,000 2,135E-03 0,03540474 ! nonhomologous end joining complex GO:0070419 6 5 0,000 2,135E-03 0,03524454 GO:0005958|DNA-dependent protein kinase-DNA ligase 4 complex, ! depyrimidination GO:0045008 5 5 0,000 2,135E-03 0,03508578 ! regulation of chromatin assembly or disassembly GO:0001672 5 5 0,000 2,135E-03 0,03492845 ! ATPase activator activity GO:0001671 5 5 0,000 2,135E-03 0,03477252 ! phosphoinositide 5-phosphatase activity GO:0034595 5 5 0,000 2,135E-03 0,03461797 GO:0004439|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, ! DNA damage response, signal transduction resulting in transcription GO:0042772 17 5 0,000 2,135E-03 0,0344648 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! calcium sensitive guanylate cyclase activator activity GO:0008048 5 5 0,000 2,135E-03 0,03431297 ! regulation of cholesterol biosynthetic process GO:0045540 5 5 0,000 2,135E-03 0,03416247 ! positive regulation of collagen metabolic process GO:0010714 6 5 0,000 2,135E-03 0,03401329 GO:0032967|positive regulation of collagen biosynthetic process, ! phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0017176 7 5 0,000 2,135E-03 0,03386541 ! regulation of protein amino acid dephosphorylation GO:0035304 7 5 0,000 2,135E-03 0,0337188 ! cardiac myofibril assembly GO:0055003 5 5 0,000 2,135E-03 0,03357346 ! anterograde axon cargo transport GO:0008089 6 5 0,000 2,135E-03 0,03342937 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 2,135E-03 0,03328651 ! GPI-anchor transamidase complex GO:0042765 5 5 0,000 2,135E-03 0,03314487 GO:0003923|GPI-anchor transamidase activity, ! regulation of leukocyte degranulation GO:0043300 5 5 0,000 2,135E-03 0,03300442 ! thiamin and derivative metabolic process GO:0042723 5 5 0,000 2,135E-03 0,03286516 ! protein localization to telomere GO:0070198 7 5 0,000 2,135E-03 0,03272708 ! response to exogenous dsRNA GO:0043330 5 5 0,000 2,135E-03 0,03259014 ! MutSalpha complex binding GO:0032407 7 5 0,000 2,135E-03 0,03245435 ! bile acid biosynthetic process GO:0006699 5 5 0,000 2,135E-03 0,03231968 ! negative regulation of fat cell differentiation GO:0045599 6 5 0,000 2,135E-03 0,03218613 ! enucleate erythrocyte differentiation GO:0043353 7 5 0,000 2,135E-03 0,03205368 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 2,135E-03 0,03192231 ! nerve growth factor binding GO:0048406 7 5 0,000 2,135E-03 0,03179202 ! platelet-derived growth factor binding GO:0048407 8 5 0,000 2,135E-03 0,03166278 ! high-density lipoprotein binding GO:0008035 6 5 0,000 2,135E-03 0,03153459 ! negative regulation of focal adhesion formation GO:0051895 5 5 0,000 2,135E-03 0,03140743 ! transcription initiation factor activity GO:0016986 5 5 0,000 2,135E-03 0,0312813 ! gas homeostasis GO:0033483 5 5 0,000 2,135E-03 0,03115618 ! Schwann cell development GO:0014044 5 5 0,000 2,135E-03 0,03103205 ! CD4-positive, alpha beta T cell differentiation GO:0043367 5 5 0,000 2,135E-03 0,0309089 ! cyclohydrolase activity GO:0019238 5 5 0,000 2,135E-03 0,03078673 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 2,135E-03 0,03066553 ! response to pheromone GO:0019236 5 5 0,000 2,135E-03 0,03054527 GO:0016503|pheromone receptor activity, ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 5 5 0,000 2,135E-03 0,03042595 ! phosphatidylserine metabolic process GO:0006658 5 5 0,000 2,135E-03 0,03030756 ! rhombomere development GO:0021546 6 5 0,000 2,135E-03 0,03019009 ! alanine transport GO:0032328 6 5 0,000 2,135E-03 0,03007353 ! superoxide-generating NADPH oxidase activity GO:0016175 5 5 0,000 2,135E-03 0,02995786 ! NAD(P)H oxidase activity GO:0016174 5 5 0,000 2,135E-03 0,02984308 ! ventral spinal cord interneuron specification GO:0021521 7 5 0,000 2,135E-03 0,02972918 GO:0021514|ventral spinal cord interneuron differentiation, GO:0060579|ventral spinal cord interneuron fate commitment, ! spinal cord motor neuron cell fate specification GO:0021520 6 5 0,000 2,135E-03 0,02961614 ! regulation of meiosis GO:0040020 6 5 0,000 2,135E-03 0,02950395 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 6 5 0,000 2,135E-03 0,02939262 GO:0000085|G2 phase of mitotic cell cycle, ! parasympathetic nervous system development GO:0048486 5 5 0,000 2,135E-03 0,02928212 ! lymphocyte costimulation GO:0031294 5 5 0,000 2,135E-03 0,02917245 GO:0031295|T cell costimulation, ! response to tumor cell GO:0002347 7 5 0,000 2,135E-03 0,0290636 ! RS domain binding GO:0050733 6 5 0,000 2,135E-03 0,02895555 ! telomerase holoenzyme complex GO:0005697 6 5 0,000 2,135E-03 0,02884831 ! negative regulation of lipoprotein metabolic process GO:0050748 6 5 0,000 2,135E-03 0,02874186 ! B cell homeostasis GO:0001782 6 5 0,000 2,135E-03 0,02863619 ! positive regulation of Wnt receptor signaling pathway GO:0030177 5 5 0,000 2,135E-03 0,0285313 ! anaphase GO:0051322 7 5 0,000 2,135E-03 0,02842717 GO:0000090|mitotic anaphase, ! S phase GO:0051320 5 5 0,000 2,135E-03 0,0283238 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of blood coagulation GO:0030194 6 5 0,000 2,135E-03 0,02822117 GO:0050820|positive regulation of coagulation, ! ribonuclease H activity GO:0004523 14 5 0,000 2,135E-03 0,02811929 ! AP-2 adaptor complex GO:0030122 5 5 0,000 2,135E-03 0,02801814 GO:0030128|clathrin coat of endocytic vesicle, ! lipase activator activity GO:0060229 6 5 0,000 2,135E-03 0,02791772 ! diuresis GO:0030146 5 5 0,000 2,135E-03 0,02781801 GO:0030147|natriuresis, ! phosphatidylcholine binding GO:0031210 5 5 0,000 2,135E-03 0,02771902 ! DNA-methyltransferase activity GO:0009008 5 5 0,000 2,135E-03 0,02762072 ! structural constituent of nuclear pore GO:0017056 5 5 0,000 2,135E-03 0,02752312 ! very-low-density lipoprotein particle clearance GO:0034447 6 5 0,000 2,135E-03 0,02742621 ! GTP-Rho binding GO:0017049 5 5 0,000 2,135E-03 0,02732998 ! glucocorticoid biosynthetic process GO:0006704 5 5 0,000 2,135E-03 0,02723442 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 2,135E-03 0,02713953 ! chondroitin sulfotransferase activity GO:0034481 6 5 0,000 2,135E-03 0,02704529 ! brown fat cell differentiation GO:0050873 5 5 0,000 2,135E-03 0,02695171 ! regulation of telomerase activity GO:0051972 6 5 0,000 2,135E-03 0,02685877 ! quaternary ammonium group transmembrane transporter activity GO:0015651 5 5 0,000 2,135E-03 0,02676647 ! TAP complex GO:0042825 5 5 0,000 2,135E-03 0,02667481 ! platelet dense granule GO:0042827 6 5 0,000 2,135E-03 0,02658377 ! bHLH transcription factor binding GO:0043425 5 5 0,000 2,135E-03 0,02649335 ! secretory granule organization GO:0033363 5 5 0,000 2,135E-03 0,02640354 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters GO:0016888 14 5 0,000 2,135E-03 0,02631434 ! ligase activity, forming phosphoric ester bonds GO:0016886 5 5 0,000 2,135E-03 0,02622574 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 2,135E-03 0,02613773 ! lamin binding GO:0005521 8 5 0,000 2,135E-03 0,02605031 ! aldehyde-lyase activity GO:0016832 6 5 0,000 2,135E-03 0,02596348 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 2,135E-03 0,02587722 ! neural plate morphogenesis GO:0001839 6 5 0,000 2,135E-03 0,02579154 ! cyclosporin A binding GO:0016018 6 5 0,000 2,135E-03 0,02570642 ! peptidoglycan receptor activity GO:0016019 5 5 0,000 2,135E-03 0,02562185 ! negative regulation of fibrinolysis GO:0051918 5 5 0,000 2,135E-03 0,02553785 ! positive regulation of telomere maintenance GO:0032206 7 5 0,000 2,135E-03 0,02545439 ! pattern recognition receptor signaling pathway GO:0002221 5 5 0,000 2,135E-03 0,02537148 GO:0002224|toll-like receptor signaling pathway, ! phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 5 5 0,000 2,135E-03 0,0252891 ! positive regulation of blood vessel endothelial cell migration GO:0043536 6 5 0,000 2,135E-03 0,02520726 ! flavin-containing monooxygenase activity GO:0004499 6 5 0,000 2,135E-03 0,02512595 ! regulation of calcium ion transport via store-operated calcium channel activity GO:0032234 5 5 0,000 2,135E-03 0,02504516 ! hemopoietic progenitor cell differentiation GO:0002244 6 5 0,000 2,135E-03 0,02496488 ! organ or tissue specific immune response GO:0002251 6 5 0,000 2,135E-03 0,02488512 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 7 5 0,000 2,135E-03 0,02480587 ! retina homeostasis GO:0001895 5 5 0,000 2,135E-03 0,02472712 ! prepulse inhibition GO:0060134 8 5 0,000 2,135E-03 0,02464887 ! maternal placenta development GO:0001893 5 5 0,000 2,135E-03 0,02457112 GO:0046697|decidualization, ! endothelial cell development GO:0001885 6 5 0,000 2,135E-03 0,02449385 ! regulation of growth hormone secretion GO:0060123 5 5 0,000 2,135E-03 0,02441707 GO:0060124|positive regulation of growth hormone secretion, ! isocitrate dehydrogenase activity GO:0004448 5 5 0,000 2,135E-03 0,02434076 ! thiamin pyrophosphate binding GO:0030976 5 5 0,000 2,135E-03 0,02426493 ! protein palmitoylation GO:0018345 5 5 0,000 2,135E-03 0,02418958 ! protein amino acid prenylation GO:0018346 6 5 0,000 2,135E-03 0,02411469 ! N-methyl-D-aspartate selective glutamate receptor complex GO:0017146 8 5 0,000 2,135E-03 0,02404026 ! stem cell division GO:0017145 6 5 0,000 2,135E-03 0,02396629 GO:0048103|somatic stem cell division, ! fibroblast growth factor binding GO:0017134 5 5 0,000 2,135E-03 0,02389277 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 6 5 0,000 2,135E-03 0,02381971 ! organ regeneration GO:0031100 6 5 0,000 2,135E-03 0,02374708 ! lymphocyte apoptosis GO:0070227 6 5 0,000 2,135E-03 0,02367491 ! positive regulation of microtubule polymerization GO:0031116 5 5 0,000 2,135E-03 0,02360316 ! negative regulation of nucleotide biosynthetic process GO:0030809 6 5 0,000 2,135E-03 0,02353185 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of developmental growth GO:0048639 6 5 0,000 2,135E-03 0,02346098 ! acyl carrier activity GO:0000036 5 5 0,000 2,135E-03 0,02339052 ! positive regulation of cAMP biosynthetic process GO:0030819 6 5 0,000 2,135E-03 0,02332049 GO:0030816|positive regulation of cAMP metabolic process, ! condensin complex GO:0000796 6 5 0,000 2,135E-03 0,02325088 ! phagocytic vesicle GO:0045335 5 5 0,000 2,135E-03 0,02318168 ! blood coagulation, extrinsic pathway GO:0007598 5 5 0,000 2,135E-03 0,02311289 ! regulation of cGMP biosynthetic process GO:0030826 5 5 0,000 2,135E-03 0,02304451 GO:0030823|regulation of cGMP metabolic process, ! citrulline metabolic process GO:0000052 14 5 0,000 2,135E-03 0,02297653 ! positive regulation of actin filament polymerization GO:0030838 5 5 0,000 2,135E-03 0,02290895 ! polyol transport GO:0015791 8 5 0,000 2,135E-03 0,02284177 ! post-embryonic morphogenesis GO:0009886 7 5 0,000 2,135E-03 0,02277498 ! pyrimidine nucleotide-sugar transport GO:0015781 5 5 0,000 2,135E-03 0,02270858 ! regulation of cell adhesion mediated by integrin GO:0033628 5 5 0,000 2,135E-03 0,02264257 ! cell adhesion mediated by integrin GO:0033627 5 5 0,000 2,135E-03 0,02257694 ! short-chain fatty acid metabolic process GO:0046459 6 5 0,000 2,135E-03 0,02251169 ! glycerol-3-phosphate metabolic process GO:0006072 6 5 0,000 2,135E-03 0,02244681 ! ethanol metabolic process GO:0006067 6 5 0,000 2,135E-03 0,02238231 GO:0006069|ethanol oxidation, GO:0034308|monohydric alcohol metabolic process, ! phosphatidic acid metabolic process GO:0046473 5 5 0,000 2,135E-03 0,02231818 ! cobalt ion transport GO:0006824 5 5 0,000 2,135E-03 0,02225441 ! cellular zinc ion homeostasis GO:0006882 6 5 0,000 2,135E-03 0,02219101 ! Golgi to plasma membrane transport GO:0006893 7 5 0,000 2,135E-03 0,02212797 ! syncytium formation by plasma membrane fusion GO:0000768 5 5 0,000 2,135E-03 0,02206528 GO:0007520|myoblast fusion, ! poly(U) RNA binding GO:0008266 5 5 0,000 2,135E-03 0,02200295 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 5 5 0,000 2,135E-03 0,02194097 ! sterol carrier activity GO:0005498 6 5 0,000 2,135E-03 0,02187934 ! adaptation of signaling pathway GO:0022401 6 5 0,000 2,135E-03 0,02181805 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! 2-oxoglutarate metabolic process GO:0006103 6 5 0,000 2,135E-03 0,02175711 ! response to acid GO:0001101 7 5 0,000 2,135E-03 0,0216965 ! fibril organization GO:0043206 5 5 0,000 2,135E-03 0,02163623 ! malate metabolic process GO:0006108 6 5 0,000 2,135E-03 0,0215763 ! regulation of dopamine uptake GO:0051584 7 5 0,000 2,135E-03 0,0215167 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! copulation GO:0007620 5 5 0,000 2,135E-03 0,02145742 ! circadian sleep/wake cycle process GO:0022410 5 5 0,000 2,135E-03 0,02139847 GO:0042749|regulation of circadian sleep/wake cycle, GO:0045187|regulation of circadian sleep/wake cycle, sleep, ! cleavage furrow GO:0032154 6 5 0,000 2,135E-03 0,02133985 ! protein maturation by protein folding GO:0022417 5 5 0,000 2,135E-03 0,02128154 ! activation of protein kinase B activity GO:0032148 15 5 0,000 2,135E-03 0,02122355 ! origin recognition complex GO:0000808 5 5 0,000 2,135E-03 0,02116588 ! neurexin binding GO:0042043 6 5 0,000 2,135E-03 0,02110852 ! sensory perception of temperature stimulus GO:0050951 8 5 0,000 2,135E-03 0,02105147 ! protein amino acid dealkylation GO:0008214 5 5 0,000 2,135E-03 0,02099473 GO:0006482|protein amino acid demethylation, ! NF-kappaB-inducing kinase activity GO:0004704 5 5 0,000 2,135E-03 0,02093829 ! lipoic acid binding GO:0031405 5 5 0,000 2,135E-03 0,02088216 ! very-low-density lipoprotein particle assembly GO:0034379 5 5 0,000 2,135E-03 0,02082632 ! lithium ion binding GO:0031403 6 5 0,000 2,135E-03 0,02077078 ! grooming behavior GO:0007625 7 5 0,000 2,135E-03 0,02071554 ! regulation of smooth muscle cell apoptosis GO:0034391 5 5 0,000 2,135E-03 0,02066059 ! ribose phosphate diphosphokinase activity GO:0004749 6 5 0,000 2,135E-03 0,02060594 ! lymph vessel development GO:0001945 6 5 0,000 2,135E-03 0,02055157 ! bicarbonate transport GO:0015701 5 5 0,000 2,135E-03 0,02049748 ! response to interferon-gamma GO:0034341 6 5 0,000 2,135E-03 0,02044368 ! protein-lysine 6-oxidase activity GO:0004720 23 5 0,000 2,135E-03 0,02039017 ! endothelial cell proliferation GO:0001935 8 5 0,000 2,135E-03 0,02033693 ! polynucleotide adenylyltransferase activity GO:0004652 5 5 0,000 2,135E-03 0,02028397 ! dorsal spinal cord development GO:0021516 6 5 0,000 2,135E-03 0,02023128 ! activation of MAPKKK activity GO:0000185 5 5 0,000 2,135E-03 0,02017887 ! synaptic vesicle maturation GO:0016188 6 5 0,000 2,135E-03 0,02012673 ! sphingoid catabolic process GO:0046521 5 5 0,000 2,135E-03 0,02007486 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 5 5 0,000 2,135E-03 0,02002325 ! neutrophil mediated immunity GO:0002446 5 5 0,000 2,135E-03 0,01997191 ! intercellular canaliculus GO:0046581 5 5 0,000 2,135E-03 0,01992083 ! dopamine binding GO:0035240 7 5 0,000 2,135E-03 0,01987001 GO:0004952|dopamine receptor activity, ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 5 5 0,000 2,135E-03 0,01981945 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 5 5 0,000 2,135E-03 0,01976915 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity GO:0003956 6 5 0,000 2,135E-03 0,0197191 ! amine oxidase activity GO:0008131 7 5 0,000 2,135E-03 0,0196693 ! monocyte activation GO:0042117 9 5 0,000 2,135E-03 0,01961976 ! negative regulation of protein binding GO:0032091 5 5 0,000 2,135E-03 0,01957046 ! regulation of response to food GO:0032095 5 5 0,000 2,135E-03 0,01952141 ! response to food GO:0032094 6 5 0,000 2,135E-03 0,01947261 ! positive regulation of protein binding GO:0032092 5 5 0,000 2,135E-03 0,01942405 ! copper ion transmembrane transporter activity GO:0005375 5 5 0,000 2,135E-03 0,01937573 ! regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 6 5 0,000 2,135E-03 0,01932765 ! hedgehog receptor activity GO:0008158 5 5 0,000 2,135E-03 0,01927981 ! lipoprotein catabolic process GO:0042159 5 5 0,000 2,135E-03 0,01923221 ! substrate-bound cell migration, cell extension GO:0006930 7 5 0,000 2,135E-03 0,01918484 ! purine salvage GO:0043101 7 5 0,000 2,135E-03 0,0191377 ! small-subunit processome GO:0032040 5 5 0,000 2,135E-03 0,01909079 ! positive regulation of catecholamine secretion GO:0033605 5 5 0,000 2,135E-03 0,01904412 ! ciliary rootlet GO:0035253 5 5 0,000 2,135E-03 0,01899767 ! myosin heavy chain binding GO:0032036 5 5 0,000 2,135E-03 0,01895144 ! nucleobase transport GO:0015851 5 5 0,000 2,135E-03 0,01890545 ! sodium ion transmembrane transporter activity GO:0015081 6 5 0,000 2,135E-03 0,01885967 ! GPI anchor binding GO:0034235 6 5 0,000 2,135E-03 0,01881412 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 2,135E-03 0,01876878 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! thrombin receptor activity GO:0015057 5 5 0,000 2,135E-03 0,01872366 ! palmitoyl-CoA hydrolase activity GO:0016290 5 5 0,000 2,135E-03 0,01867876 ! basic amino acid transport GO:0015802 5 5 0,000 2,135E-03 0,01863408 ! dendritic shaft GO:0043198 5 5 0,000 2,135E-03 0,0185896 ! terminal button GO:0043195 7 5 0,000 2,135E-03 0,01854534 ! arginine N-methyltransferase activity GO:0016273 6 5 0,000 2,135E-03 0,01850129 GO:0016274|protein-arginine N-methyltransferase activity, ! neuronal ion channel clustering GO:0045161 5 5 0,000 2,135E-03 0,01845745 ! transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 6 5 0,000 2,135E-03 0,01841382 ! homeostasis of number of cells within a tissue GO:0048873 7 5 0,000 2,135E-03 0,01837039 ! negative regulation of peptide secretion GO:0002792 5 5 0,000 2,135E-03 0,01832716 GO:0046676|negative regulation of insulin secretion, ! neural nucleus development GO:0048857 6 5 0,000 2,135E-03 0,01828414 ! response to UV-C GO:0010225 15 5 0,000 2,135E-03 0,01824132 ! positive regulation of organ growth GO:0046622 5 5 0,000 2,135E-03 0,0181987 ! response to arsenic GO:0046685 6 5 0,000 2,135E-03 0,01815628 ! IgE binding GO:0019863 5 5 0,000 2,135E-03 0,01811406 ! positive regulation of T cell cytokine production GO:0002726 5 5 0,000 2,135E-03 0,01807203 GO:0032743|positive regulation of interleukin-2 production, ! transcription-coupled nucleotide-excision repair GO:0006283 5 5 0,000 2,135E-03 0,01803019 ! monoamine transmembrane transporter activity GO:0008504 6 5 0,000 2,135E-03 0,01798855 ! response to copper ion GO:0046688 5 5 0,000 2,135E-03 0,01794711 ! response to cadmium ion GO:0046686 5 5 0,000 2,135E-03 0,01790585 ! tetrahydrofolate metabolic process GO:0046653 5 5 0,000 2,135E-03 0,01786478 ! regulation of interleukin-1 beta production GO:0032651 5 5 0,000 2,135E-03 0,0178239 ! protein autoprocessing GO:0016540 6 5 0,000 2,135E-03 0,01778321 ! intracellular cyclic nucleotide activated cation channel activity GO:0005221 5 5 0,000 2,135E-03 0,0177427 GO:0043855|cyclic nucleotide-gated ion channel activity, ! negative regulation of monooxygenase activity GO:0032769 5 5 0,000 2,135E-03 0,01770237 ! ryanodine-sensitive calcium-release channel activity GO:0005219 5 5 0,000 2,135E-03 0,01766223 GO:0005218|intracellular ligand-gated calcium channel activity, ! positive regulation of interleukin-10 production GO:0032733 5 5 0,000 2,135E-03 0,01762227 ! mitotic recombination GO:0006312 15 5 0,000 2,135E-03 0,01758249 ! negative regulation of interleukin-6 production GO:0032715 6 5 0,000 2,135E-03 0,01754289 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 2,135E-03 0,01750347 ! membrane to membrane docking GO:0022614 5 5 0,000 2,135E-03 0,01746422 ! regulation of transcription from RNA polymerase I promoter GO:0006356 14 5 0,000 2,135E-03 0,01742515 ! translation activator activity GO:0008494 5 5 0,000 2,135E-03 0,01738626 ! somatostatin receptor activity GO:0004994 5 5 0,000 2,135E-03 0,01734754 ! melanocortin receptor activity GO:0004977 6 5 0,000 2,135E-03 0,01730899 ! serine-type carboxypeptidase activity GO:0004185 5 5 0,000 2,135E-03 0,01727061 GO:0070008|serine-type exopeptidase activity, ! protein phosphatase 2A binding GO:0051721 6 5 0,000 2,135E-03 0,0172324 ! salivary gland morphogenesis GO:0007435 5 5 0,000 2,135E-03 0,01719436 ! galactosidase activity GO:0015925 5 5 0,000 2,135E-03 0,01715648 ! prostaglandin E receptor activity GO:0004957 7 5 0,000 2,135E-03 0,01711878 ! cellular response to nutrient GO:0031670 5 5 0,000 2,135E-03 0,01708124 ! ATP-dependent chromatin remodeling GO:0043044 5 5 0,000 2,135E-03 0,01704386 ! L-cystine transmembrane transporter activity GO:0015184 5 5 0,000 2,135E-03 0,01700665 ! glycine transmembrane transporter activity GO:0015187 7 5 0,000 2,135E-03 0,01696959 ! L-gamma-aminobutyric acid transmembrane transporter activity GO:0015185 6 5 0,000 2,135E-03 0,0169327 ! A band GO:0031672 5 5 0,000 2,135E-03 0,01689597 ! heat generation GO:0031649 5 5 0,000 2,135E-03 0,0168594 ! flagellum organization GO:0043064 5 5 0,000 2,135E-03 0,01682299 GO:0009296|flagellum assembly, ! tricarboxylic acid cycle enzyme complex GO:0045239 6 5 0,000 2,135E-03 0,01678673 ! disaccharide metabolic process GO:0005984 6 5 0,000 2,135E-03 0,01675063 ! glycogen catabolic process GO:0005980 16 5 0,000 2,135E-03 0,01671469 ! dopamine biosynthetic process GO:0042416 6 5 0,000 2,135E-03 0,01667889 ! 5'-3' exonuclease activity GO:0008409 14 5 0,000 2,135E-03 0,01664326 ! chromocenter GO:0010369 5 5 0,000 2,135E-03 0,01660777 ! glial cell migration GO:0008347 5 5 0,000 2,135E-03 0,01657243 ! epidermal growth factor receptor binding GO:0005154 7 5 0,000 2,135E-03 0,01653725 ! calcium-dependent phospholipase A2 activity GO:0047498 5 5 0,000 2,135E-03 0,01650221 ! negative regulation of NF-kappaB import into nucleus GO:0042347 5 5 0,000 2,135E-03 0,01646732 ! growth hormone receptor binding GO:0005131 5 5 0,000 2,135E-03 0,01643258 ! protein serine/threonine phosphatase inhibitor activity GO:0004865 6 5 0,000 2,135E-03 0,01639799 ! negative regulation of smooth muscle contraction GO:0045986 7 5 0,000 2,135E-03 0,01636354 ! aminomethyltransferase activity GO:0004047 5 5 0,000 2,135E-03 0,01632923 ! aminoacylase activity GO:0004046 5 5 0,000 2,135E-03 0,01629507 ! penetration of zona pellucida GO:0007341 6 5 0,000 2,135E-03 0,01626105 ! alcohol dehydrogenase activity, zinc-dependent GO:0004024 5 5 0,000 2,135E-03 0,01622717 ! nucleus localization GO:0051647 5 5 0,000 2,135E-03 0,01619344 ! 3-chloroallyl aldehyde dehydrogenase activity GO:0004028 5 5 0,000 2,135E-03 0,01615984 ! carnitine metabolic process GO:0009437 5 5 0,000 2,135E-03 0,01612638 GO:0006577|betaine metabolic process, ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 2,562E-03 0,01930807 ! regulation of helicase activity GO:0051095 6 6 0,000 2,562E-03 0,01926826 ! response to oxygen radical GO:0000305 6 6 0,000 2,562E-03 0,01922861 ! positive regulation of axon extension GO:0045773 7 6 0,000 2,562E-03 0,01918913 ! forebrain neuron differentiation GO:0021879 6 6 0,000 2,562E-03 0,01914981 ! forebrain regionalization GO:0021871 7 6 0,000 2,562E-03 0,01911064 ! meiotic prophase I GO:0007128 7 6 0,000 2,562E-03 0,01907164 ! hydroxymethyl-, formyl- and related transferase activity GO:0016742 6 6 0,000 2,562E-03 0,0190328 ! inositol trisphosphate phosphatase activity GO:0046030 8 6 0,000 2,562E-03 0,01899412 GO:0004445|inositol-polyphosphate 5-phosphatase activity, ! regulation of lipid kinase activity GO:0043550 6 6 0,000 2,562E-03 0,01895559 ! SMAD protein nuclear translocation GO:0007184 7 6 0,000 2,562E-03 0,01891722 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 9 6 0,000 2,562E-03 0,018879 ! carbohydrate phosphorylation GO:0046835 7 6 0,000 2,562E-03 0,01884094 ! phosphoinositide 3-kinase binding GO:0043548 6 6 0,000 2,562E-03 0,01880303 ! protein amino acid sulfation GO:0006477 9 6 0,000 2,562E-03 0,01876527 GO:0051923|sulfation, ! diphosphotransferase activity GO:0016778 7 6 0,000 2,562E-03 0,01872767 ! establishment of tissue polarity GO:0007164 8 6 0,000 2,562E-03 0,01869021 ! protein thiol-disulfide exchange GO:0006467 6 6 0,000 2,562E-03 0,0186529 ! receptor guanylyl cyclase signaling pathway GO:0007168 6 6 0,000 2,562E-03 0,01861575 ! embryonic camera-type eye development GO:0031076 9 6 0,000 2,562E-03 0,01857874 GO:0048596|embryonic camera-type eye morphogenesis, ! hexokinase activity GO:0004396 7 6 0,000 2,562E-03 0,01854188 ! regulation of mitochondrial membrane permeability GO:0046902 7 6 0,000 2,562E-03 0,01850516 ! neurofilament cytoskeleton organization GO:0060052 6 6 0,000 2,562E-03 0,01846859 ! Notch receptor processing GO:0007220 7 6 0,000 2,562E-03 0,01843216 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0016714 8 6 0,000 2,562E-03 0,01839588 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0016717 7 6 0,000 2,562E-03 0,01835974 ! eukaryotic translation initiation factor 2B complex GO:0005851 6 6 0,000 2,562E-03 0,01832374 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 6 0,000 2,562E-03 0,01828788 ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 6 0,000 2,562E-03 0,01825216 ! neurofilament GO:0005883 7 6 0,000 2,562E-03 0,01821658 ! glial cell fate commitment GO:0021781 7 6 0,000 2,562E-03 0,01818114 ! cytoplasmic dynein complex GO:0005868 7 6 0,000 2,562E-03 0,01814584 ! dynactin complex GO:0005869 7 6 0,000 2,562E-03 0,01811067 ! fibroblast growth factor receptor antagonist activity GO:0030353 7 6 0,000 2,562E-03 0,01807564 GO:0005152|interleukin-1 receptor antagonist activity, ! enoyl-CoA hydratase activity GO:0004300 6 6 0,000 2,562E-03 0,01804074 ! oocyte maturation GO:0001556 6 6 0,000 2,562E-03 0,01800598 ! DNA replication origin binding GO:0003688 6 6 0,000 2,562E-03 0,01797136 ! reflex GO:0060004 10 6 0,000 2,562E-03 0,01793686 ! positive regulation of glycolysis GO:0045821 6 6 0,000 2,562E-03 0,0179025 ! parathyroid gland development GO:0060017 6 6 0,000 2,562E-03 0,01786827 ! anagen GO:0042640 7 6 0,000 2,562E-03 0,01783417 ! protein-cofactor linkage GO:0018065 15 6 0,000 2,562E-03 0,0178002 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 6 6 0,000 2,562E-03 0,01776636 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! protein targeting to ER GO:0045047 7 6 0,000 2,562E-03 0,01773265 GO:0006614|SRP-dependent cotranslational protein targeting to membrane, ! 3'-phosphoadenosine 5'-phosphosulfate binding GO:0050656 6 6 0,000 2,562E-03 0,01769906 ! skeletal myofibril assembly GO:0014866 6 6 0,000 2,562E-03 0,01766561 ! structural constituent of tooth enamel GO:0030345 7 6 0,000 2,562E-03 0,01763227 ! cysteine metabolic process GO:0006534 7 6 0,000 2,562E-03 0,01759907 ! glycine catabolic process GO:0006546 6 6 0,000 2,562E-03 0,01756599 ! adenohypophysis development GO:0021984 6 6 0,000 2,562E-03 0,01753303 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 6 6 0,000 2,562E-03 0,0175002 ! deoxyribonucleotide biosynthetic process GO:0009263 7 6 0,000 2,562E-03 0,01746749 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 6 0,000 2,562E-03 0,0174349 ! microtubule nucleation GO:0007020 7 6 0,000 2,562E-03 0,01740243 ! proline biosynthetic process GO:0006561 8 6 0,000 2,562E-03 0,01737008 ! tryptophan metabolic process GO:0006568 6 6 0,000 2,562E-03 0,01733786 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GO:0016671 6 6 0,000 2,562E-03 0,01730575 ! thyroid hormone generation GO:0006590 6 6 0,000 2,562E-03 0,01727376 ! melanin biosynthetic process from tyrosine GO:0006583 7 6 0,000 2,562E-03 0,01724189 ! retinoid X receptor binding GO:0046965 7 6 0,000 2,562E-03 0,01721014 ! proton-transporting V-type ATPase, V0 domain GO:0033179 6 6 0,000 2,562E-03 0,0171785 ! transforming growth factor beta receptor activity, type I GO:0005025 7 6 0,000 2,562E-03 0,01714698 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 2,562E-03 0,01711558 ! sister chromatid cohesion GO:0007062 6 6 0,000 2,562E-03 0,01708429 ! retinoic acid receptor signaling pathway GO:0048384 9 6 0,000 2,562E-03 0,01705311 ! positive regulation of transporter activity GO:0032411 8 6 0,000 2,562E-03 0,01702205 GO:0032414|positive regulation of ion transmembrane transporter activity, ! cerebral cortex neuron differentiation GO:0021895 7 6 0,000 2,562E-03 0,0169911 ! regulation of fatty acid beta-oxidation GO:0031998 6 6 0,000 2,562E-03 0,01696026 ! p53 binding GO:0002039 6 6 0,000 2,562E-03 0,01692954 ! demethylase activity GO:0032451 6 6 0,000 2,562E-03 0,01689892 ! positive regulation of nitric-oxide synthase activity GO:0051000 6 6 0,000 2,562E-03 0,01686842 ! regulation of platelet activation GO:0010543 7 6 0,000 2,562E-03 0,01683803 ! lipid phosphatase activity GO:0042577 7 6 0,000 2,562E-03 0,01680774 ! lens morphogenesis in camera-type eye GO:0002089 6 6 0,000 2,562E-03 0,01677757 ! guanylate cyclase activator activity GO:0030250 6 6 0,000 2,562E-03 0,0167475 GO:0010853|cyclase activator activity, ! negative regulation of carbohydrate metabolic process GO:0045912 8 6 0,000 2,562E-03 0,01671754 GO:0010677|negative regulation of cellular carbohydrate metabolic process, ! positive regulation of exocytosis GO:0045921 6 6 0,000 2,562E-03 0,01668769 ! protein tyrosine kinase activator activity GO:0030296 8 6 0,000 2,562E-03 0,01665794 ! protein import into mitochondrial inner membrane GO:0045039 7 6 0,000 2,562E-03 0,0166283 GO:0042719|mitochondrial intermembrane space protein transporter complex, ! positive regulation of steroid metabolic process GO:0045940 6 6 0,000 2,562E-03 0,01659877 ! LIM domain binding GO:0030274 7 6 0,000 2,562E-03 0,01656934 ! negative regulation of translational initiation GO:0045947 6 6 0,000 2,562E-03 0,01654001 ! positive regulation vascular endothelial growth factor production GO:0010575 6 6 0,000 2,562E-03 0,01651079 ! 5S class rRNA transcription GO:0042791 6 6 0,000 2,562E-03 0,01648167 GO:0042797|tRNA transcription from RNA polymerase III promoter, GO:0000127|transcription factor TFIIIC complex, ! integral to mitochondrial outer membrane GO:0031307 6 6 0,000 2,562E-03 0,01645265 ! axon guidance receptor activity GO:0008046 6 6 0,000 2,562E-03 0,01642373 ! zinc ion homeostasis GO:0055069 7 6 0,000 2,562E-03 0,01639492 ! positive regulation of gliogenesis GO:0014015 7 6 0,000 2,562E-03 0,01636621 GO:0045687|positive regulation of glial cell differentiation, ! centrosome duplication GO:0051298 7 6 0,000 2,562E-03 0,0163376 ! protein targeting to lysosome GO:0006622 6 6 0,000 2,562E-03 0,01630908 ! hyaluronan metabolic process GO:0030212 8 6 0,000 2,562E-03 0,01628067 ! protein retention in ER lumen GO:0006621 6 6 0,000 2,562E-03 0,01625236 ! ventricular cardiac muscle cell differentiation GO:0055012 8 6 0,000 2,562E-03 0,01622414 ! circadian sleep/wake cycle GO:0042745 7 6 0,000 2,562E-03 0,01619602 ! dynein binding GO:0045502 6 6 0,000 2,562E-03 0,016168 ! regulation of dendrite development GO:0050773 6 6 0,000 2,562E-03 0,01614008 ! peptidyl-arginine modification GO:0018195 6 6 0,000 2,562E-03 0,01611225 ! eating behavior GO:0042755 7 6 0,000 2,562E-03 0,01608452 ! protein localization to chromosome GO:0034502 8 6 0,000 2,562E-03 0,01605688 ! Hsp90 protein binding GO:0051879 7 6 0,000 2,562E-03 0,01602934 ! glycolipid binding GO:0051861 7 6 0,000 2,562E-03 0,01600189 ! MutLalpha complex binding GO:0032405 8 6 0,000 2,562E-03 0,01597454 ! mast cell activation GO:0045576 6 6 0,000 2,562E-03 0,01594728 ! nucleoside catabolic process GO:0009164 7 6 0,000 2,562E-03 0,01592011 ! phosphatidylinositol biosynthetic process GO:0006661 6 6 0,000 2,562E-03 0,01589304 ! molybdopterin cofactor biosynthetic process GO:0032324 15 6 0,000 2,562E-03 0,01586605 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! negative regulation of multicellular organism growth GO:0040015 6 6 0,000 2,562E-03 0,01583916 ! RNA polymerase II transcription elongation factor activity GO:0016944 6 6 0,000 2,562E-03 0,01581236 ! lipoxygenase activity GO:0016165 6 6 0,000 2,562E-03 0,01578565 ! regulation of myeloid leukocyte mediated immunity GO:0002886 6 6 0,000 2,562E-03 0,01575903 ! alpha DNA polymerase:primase complex GO:0005658 16 6 0,000 2,562E-03 0,0157325 ! DNA-directed RNA polymerase III complex GO:0005666 6 6 0,000 2,562E-03 0,01570606 ! DNA replication factor C complex GO:0005663 7 6 0,000 2,562E-03 0,01567971 ! DNA replication factor A complex GO:0005662 7 6 0,000 2,562E-03 0,01565344 ! establishment of chromosome localization GO:0051303 15 6 0,000 2,562E-03 0,01562727 GO:0050000|chromosome localization, ! cilium morphogenesis GO:0060271 6 6 0,000 2,562E-03 0,01560118 ! nucleolar ribonuclease P complex GO:0005655 6 6 0,000 2,562E-03 0,01557518 GO:0030677|ribonuclease P complex, GO:0030681|multimeric ribonuclease P complex, ! intracellular lipid transport GO:0032365 6 6 0,000 2,562E-03 0,01554926 ! chromatin assembly complex GO:0005678 16 6 0,000 2,562E-03 0,01552343 ! sex chromatin GO:0001739 6 6 0,000 2,562E-03 0,01549769 GO:0000803|sex chromosome, ! morphogenesis of a polarized epithelium GO:0001738 7 6 0,000 2,562E-03 0,01547203 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 7 6 0,000 2,562E-03 0,01544645 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! SAP kinase activity GO:0016909 7 6 0,000 2,562E-03 0,01542097 ! regulation of inflammatory response to antigenic stimulus GO:0002861 6 6 0,000 2,562E-03 0,01539556 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 7 6 0,000 2,562E-03 0,01537024 ! positive regulation of pseudopodium assembly GO:0031274 6 6 0,000 2,562E-03 0,015345 GO:0031272|regulation of pseudopodium assembly, ! regulation of lipoprotein metabolic process GO:0050746 7 6 0,000 2,562E-03 0,01531984 ! phosphatidylserine binding GO:0001786 6 6 0,000 2,562E-03 0,01529477 ! alpha-mannosidase activity GO:0004559 8 6 0,000 2,562E-03 0,01526978 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 6 0,000 2,562E-03 0,01524487 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 2,562E-03 0,01522004 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 11 6 0,000 2,562E-03 0,01519529 GO:0002820|negative regulation of adaptive immune response, ! myeloid dendritic cell activation GO:0001773 8 6 0,000 2,562E-03 0,01517063 GO:0043011|myeloid dendritic cell differentiation, ! immunological synapse GO:0001772 6 6 0,000 2,562E-03 0,01514604 ! leading edge membrane GO:0031256 8 6 0,000 2,562E-03 0,01512153 ! photoreceptor connecting cilium GO:0032391 7 6 0,000 2,562E-03 0,0150971 ! CARD domain binding GO:0050700 6 6 0,000 2,562E-03 0,01507275 ! regulation of muscle cell apoptosis GO:0010660 7 6 0,000 2,562E-03 0,01504848 ! COPII vesicle coat GO:0030127 7 6 0,000 2,562E-03 0,01502428 GO:0012507|ER to Golgi transport vesicle membrane, ! molybdenum ion binding GO:0030151 15 6 0,000 2,562E-03 0,01500017 ! glutathione biosynthetic process GO:0006750 7 6 0,000 2,562E-03 0,01497613 ! positive regulation of erythrocyte differentiation GO:0045648 8 6 0,000 2,562E-03 0,01495217 ! positive regulation of epidermis development GO:0045684 8 6 0,000 2,562E-03 0,01492828 ! proteasome regulator activity GO:0010860 6 6 0,000 2,562E-03 0,01490447 ! ceramidase activity GO:0017040 6 6 0,000 2,562E-03 0,01488074 ! antibiotic transport GO:0042891 7 6 0,000 2,562E-03 0,01485708 ! tetrahydrobiopterin biosynthetic process GO:0006729 7 6 0,000 2,562E-03 0,0148335 ! regulation of T-helper cell differentiation GO:0045622 6 6 0,000 2,562E-03 0,01480999 ! sodium channel regulator activity GO:0017080 6 6 0,000 2,562E-03 0,01478656 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 2,562E-03 0,0147632 ! regulation of protein homodimerization activity GO:0043496 9 6 0,000 2,562E-03 0,01473991 ! response to fluid shear stress GO:0034405 6 6 0,000 2,562E-03 0,0147167 ! lymph node development GO:0048535 6 6 0,000 2,562E-03 0,01469356 ! negative regulation of viral reproduction GO:0048525 7 6 0,000 2,562E-03 0,01467049 ! triglyceride catabolic process GO:0019433 15 6 0,000 2,562E-03 0,0146475 ! positive regulation of fatty acid oxidation GO:0046321 6 6 0,000 2,562E-03 0,01462458 ! ectodermal gut morphogenesis GO:0048567 7 6 0,000 2,562E-03 0,01460173 GO:0007439|ectodermal gut development, ! T cell activation during immune response GO:0002286 6 6 0,000 2,562E-03 0,01457895 ! negative regulation of lipase activity GO:0060192 6 6 0,000 2,562E-03 0,01455624 ! activation of innate immune response GO:0002218 6 6 0,000 2,562E-03 0,0145336 GO:0002758|innate immune response-activating signal transduction, ! regulation of telomere maintenance via telomerase GO:0032210 7 6 0,000 2,562E-03 0,01451103 ! sarcoglycan complex GO:0016012 8 6 0,000 2,562E-03 0,01448854 ! natural killer cell mediated immunity GO:0002228 7 6 0,000 2,562E-03 0,01446611 GO:0042267|natural killer cell mediated cytotoxicity, ! phosphatidylinositol-4,5-bisphosphate binding GO:0005546 6 6 0,000 2,562E-03 0,01444375 ! neural plate development GO:0001840 7 6 0,000 2,562E-03 0,01442146 ! regulation of synaptic transmission, GABAergic GO:0032228 15 6 0,000 2,562E-03 0,01439924 ! catecholamine transport GO:0051937 6 6 0,000 2,562E-03 0,01437708 ! ether hydrolase activity GO:0016803 7 6 0,000 2,562E-03 0,014355 ! FACIT collagen GO:0005593 6 6 0,000 2,562E-03 0,01433298 ! lactate dehydrogenase activity GO:0004457 6 6 0,000 2,562E-03 0,01431103 ! regulation of T cell receptor signaling pathway GO:0050856 7 6 0,000 2,562E-03 0,01428915 ! collagen type IV GO:0005587 6 6 0,000 2,562E-03 0,01426734 ! negative regulation of DNA replication initiation GO:0032297 6 6 0,000 2,562E-03 0,01424559 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 7 6 0,000 2,562E-03 0,0142239 ! drug metabolic process GO:0017144 6 6 0,000 2,562E-03 0,01420229 ! extracellular matrix structural constituent conferring tensile strength GO:0030020 6 6 0,000 2,562E-03 0,01418074 ! negative regulation of synaptic transmission GO:0050805 6 6 0,000 2,562E-03 0,01415925 ! hyalurononglucosaminidase activity GO:0004415 6 6 0,000 2,562E-03 0,01413783 ! nucleoside-diphosphatase activity GO:0017110 6 6 0,000 2,562E-03 0,01411647 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 6 6 0,000 2,562E-03 0,01409518 ! regulation of microtubule polymerization GO:0031113 6 6 0,000 2,562E-03 0,01407395 ! cellular anion homeostasis GO:0030002 6 6 0,000 2,562E-03 0,01405279 GO:0055081|anion homeostasis, ! regulation of MHC class II biosynthetic process GO:0045346 6 6 0,000 2,562E-03 0,01403169 ! negative regulation of fibroblast proliferation GO:0048147 6 6 0,000 2,562E-03 0,01401065 ! behavioral response to cocaine GO:0048148 9 6 0,000 2,562E-03 0,01398968 ! translation initiation factor binding GO:0031369 6 6 0,000 2,562E-03 0,01396877 ! nucleotide-sugar transport GO:0015780 6 6 0,000 2,562E-03 0,01394792 ! sulfur amino acid transmembrane transporter activity GO:0000099 6 6 0,000 2,562E-03 0,01392713 ! virion attachment to host cell surface receptor GO:0019062 6 6 0,000 2,562E-03 0,01390641 ! quaternary ammonium group binding GO:0050997 7 6 0,000 2,562E-03 0,01388574 ! actin-dependent ATPase activity GO:0030898 7 6 0,000 2,562E-03 0,01386514 ! reproductive behavior GO:0019098 8 6 0,000 2,562E-03 0,0138446 ! response to growth hormone stimulus GO:0060416 7 6 0,000 2,562E-03 0,01382412 GO:0060396|growth hormone receptor signaling pathway, ! negative regulation of JAK-STAT cascade GO:0046426 8 6 0,000 2,562E-03 0,0138037 ! nucleotide-excision repair, DNA incision GO:0033683 6 6 0,000 2,562E-03 0,01378334 ! negative regulation of cell-cell adhesion GO:0022408 8 6 0,000 2,562E-03 0,01376304 ! positive regulation of cell-cell adhesion GO:0022409 7 6 0,000 2,562E-03 0,0137428 ! induction of positive chemotaxis GO:0050930 7 6 0,000 2,562E-03 0,01372262 ! cohesin complex GO:0008278 6 6 0,000 2,562E-03 0,0137025 ! regulation of collagen biosynthetic process GO:0032965 7 6 0,000 2,562E-03 0,01368244 ! citrate metabolic process GO:0006101 7 6 0,000 2,562E-03 0,01366243 ! myelin sheath GO:0043209 8 6 0,000 2,562E-03 0,01364249 ! phototransduction, visible light GO:0007603 6 6 0,000 2,562E-03 0,0136226 ! opsonization GO:0008228 7 6 0,000 2,562E-03 0,01360277 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016308 7 6 0,000 2,562E-03 0,013583 ! regulation of dopamine metabolic process GO:0042053 8 6 0,000 2,562E-03 0,01356329 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 7 6 0,000 2,562E-03 0,01354363 ! regulation of potassium ion transport GO:0043266 8 6 0,000 2,562E-03 0,01352403 ! cell migration involved in gastrulation GO:0042074 7 6 0,000 2,562E-03 0,01350449 ! chemoattractant activity GO:0042056 6 6 0,000 2,562E-03 0,013485 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine GO:0001993 8 6 0,000 2,562E-03 0,01346557 ! low-density lipoprotein particle remodeling GO:0034374 6 6 0,000 2,562E-03 0,01344619 ! ornithine decarboxylase regulator activity GO:0042979 6 6 0,000 2,562E-03 0,01342688 ! leukocyte degranulation GO:0043299 6 6 0,000 2,562E-03 0,01340761 ! bile acid and bile salt transport GO:0015721 7 6 0,000 2,562E-03 0,0133884 ! regulation of cytokine-mediated signaling pathway GO:0001959 11 6 0,000 2,562E-03 0,01336925 ! mitochondrial genome maintenance GO:0000002 6 6 0,000 2,562E-03 0,01335015 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 6 0,000 2,562E-03 0,01333111 ! DNA topoisomerase activity GO:0003916 6 6 0,000 2,562E-03 0,01331212 ! protein geranylgeranyltransferase activity GO:0004661 7 6 0,000 2,562E-03 0,01329318 ! ceramide biosynthetic process GO:0046513 6 6 0,000 2,562E-03 0,0132743 ! cyclin-dependent protein kinase activating kinase holoenzyme complex GO:0019907 7 6 0,000 2,562E-03 0,01325547 ! activin receptor activity GO:0017002 7 6 0,000 2,562E-03 0,01323669 ! astrocyte differentiation GO:0048708 6 6 0,000 2,562E-03 0,01321797 ! syncytium formation GO:0006949 6 6 0,000 2,562E-03 0,0131993 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 2,562E-03 0,01318068 ! neutrophil activation GO:0042119 6 6 0,000 2,562E-03 0,01316212 ! regulation of muscle hypertrophy GO:0014743 6 6 0,000 2,562E-03 0,01314361 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! regulation of appetite GO:0032098 6 6 0,000 2,562E-03 0,01312515 ! positive regulation of activated T cell proliferation GO:0042104 7 6 0,000 2,562E-03 0,01310674 ! positive transcription elongation factor activity GO:0008159 7 6 0,000 2,562E-03 0,01308838 ! NuA4 histone acetyltransferase complex GO:0035267 8 6 0,000 2,562E-03 0,01307008 ! cellular polysaccharide catabolic process GO:0044247 17 6 0,000 2,562E-03 0,01305182 GO:0009251|glucan catabolic process, ! response to salt stress GO:0009651 7 6 0,000 2,562E-03 0,01303362 ! neuron apoptosis GO:0051402 7 6 0,000 2,562E-03 0,01301547 ! folic acid transport GO:0015884 8 6 0,000 2,562E-03 0,01299736 ! carnitine transport GO:0015879 6 6 0,000 2,562E-03 0,01297931 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 6 6 0,000 2,562E-03 0,01296131 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, ! parturition GO:0007567 7 6 0,000 2,562E-03 0,01294336 ! S-methyltransferase activity GO:0008172 6 6 0,000 2,562E-03 0,01292546 ! phospholipase D activity GO:0004630 6 6 0,000 2,562E-03 0,0129076 ! poly-pyrimidine tract binding GO:0008187 6 6 0,000 2,562E-03 0,0128898 ! intercalated disc GO:0014704 8 6 0,000 2,562E-03 0,01287205 ! G2/M transition checkpoint GO:0031576 24 6 0,000 2,562E-03 0,01285434 GO:0031572|G2/M transition DNA damage checkpoint, ! interaction with symbiont GO:0051702 6 6 0,000 2,562E-03 0,01283668 ! IgG binding GO:0019864 6 6 0,000 2,562E-03 0,01281907 ! regulation of T cell cytokine production GO:0002724 6 6 0,000 2,562E-03 0,01280151 ! 3-hydroxyacyl-CoA dehydrogenase activity GO:0003857 6 6 0,000 2,562E-03 0,012784 ! benzodiazepine receptor activity GO:0008503 7 6 0,000 2,562E-03 0,01276654 ! antigen processing and presentation of exogenous antigen GO:0019884 7 6 0,000 2,562E-03 0,01274912 ! regulation of T cell differentiation in the thymus GO:0033081 7 6 0,000 2,562E-03 0,01273175 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 6 6 0,000 2,562E-03 0,01271443 ! regulation of interleukin-4 production GO:0032673 6 6 0,000 2,562E-03 0,01269715 ! dendrite morphogenesis GO:0048813 7 6 0,000 2,562E-03 0,01267993 ! regulation of interleukin-1 production GO:0032652 7 6 0,000 2,562E-03 0,01266274 ! ribosomal large subunit biogenesis GO:0042273 7 6 0,000 2,562E-03 0,01264561 ! regulation of myeloid cell apoptosis GO:0033032 8 6 0,000 2,562E-03 0,01262852 ! nucleosome disassembly GO:0006337 7 6 0,000 2,562E-03 0,01261148 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! general transcriptional repressor activity GO:0016565 7 6 0,000 2,562E-03 0,01259448 ! regulation of mast cell activation GO:0033003 6 6 0,000 2,562E-03 0,01257753 ! tetracycline transporter activity GO:0008493 7 6 0,000 2,562E-03 0,01256063 GO:0042895|antibiotic transporter activity, ! guanylyltransferase activity GO:0070568 7 6 0,000 2,562E-03 0,01254377 ! receptor internalization GO:0031623 8 6 0,000 2,562E-03 0,01252695 ! N-formyl peptide receptor activity GO:0004982 6 6 0,000 2,562E-03 0,01251018 ! coenzyme A biosynthetic process GO:0015937 6 6 0,000 2,562E-03 0,01249346 ! histamine receptor activity GO:0004969 7 6 0,000 2,562E-03 0,01247678 ! N-methyl-D-aspartate selective glutamate receptor activity GO:0004972 9 6 0,000 2,562E-03 0,01246014 ! pyrimidine nucleotide sugar transmembrane transporter activity GO:0015165 6 6 0,000 2,562E-03 0,01244355 ! protein deubiquitination GO:0016579 6 6 0,000 2,562E-03 0,012427 ! axonal fasciculation GO:0007413 7 6 0,000 2,562E-03 0,0124105 ! basic amino acid transmembrane transporter activity GO:0015174 6 6 0,000 2,562E-03 0,01239404 ! cytidine deaminase activity GO:0004126 6 6 0,000 2,562E-03 0,01237762 ! lipopolysaccharide-mediated signaling pathway GO:0031663 6 6 0,000 2,562E-03 0,01236125 ! energy coupled proton transport, against electrochemical gradient GO:0015988 7 6 0,000 2,562E-03 0,01234492 GO:0015991|ATP hydrolysis coupled proton transport, ! alpha-adrenergic receptor activity GO:0004936 9 6 0,000 2,562E-03 0,01232863 ! cytochrome-b5 reductase activity GO:0004128 7 6 0,000 2,562E-03 0,01231239 ! glycine binding GO:0016594 9 6 0,000 2,562E-03 0,01229619 ! apical protein localization GO:0045176 7 6 0,000 2,562E-03 0,01228003 ! ankyrin binding GO:0030506 6 6 0,000 2,562E-03 0,01226392 ! proton-transporting ATP synthase complex, catalytic core F(1) GO:0045261 6 6 0,000 2,562E-03 0,01224784 ! thyroid hormone receptor activity GO:0004887 7 6 0,000 2,562E-03 0,01223181 ! tyrosine phosphorylation of STAT protein GO:0007260 7 6 0,000 2,562E-03 0,01221582 ! progesterone metabolic process GO:0042448 6 6 0,000 2,562E-03 0,01219988 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 7 6 0,000 2,562E-03 0,01218397 ! GDP-dissociation inhibitor activity GO:0005092 6 6 0,000 2,562E-03 0,01216811 ! type II transforming growth factor beta receptor binding GO:0005114 6 6 0,000 2,562E-03 0,01215228 ! ATP catabolic process GO:0006200 6 6 0,000 2,562E-03 0,0121365 ! CoA carboxylase activity GO:0016421 6 6 0,000 2,562E-03 0,01212076 ! determination of adult lifespan GO:0008340 6 6 0,000 2,562E-03 0,01210506 ! S-acyltransferase activity GO:0016417 6 6 0,000 2,562E-03 0,0120894 ! somatic stem cell maintenance GO:0035019 6 6 0,000 2,562E-03 0,01207378 ! carnitine O-acyltransferase activity GO:0016406 6 6 0,000 2,562E-03 0,0120582 ! IkappaB kinase complex GO:0008385 7 6 0,000 2,562E-03 0,01204266 ! nucleobase transmembrane transporter activity GO:0015205 7 6 0,000 2,562E-03 0,01202716 ! store-operated calcium channel activity GO:0015279 6 6 0,000 2,562E-03 0,0120117 ! alkaline phosphatase activity GO:0004035 7 6 0,000 2,562E-03 0,01199628 ! aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 6 6 0,000 2,562E-03 0,0119809 ! unconventional myosin complex GO:0016461 8 6 0,000 2,562E-03 0,01196556 ! tRNA transcription GO:0009304 7 7 0,000 2,988E-03 0,01393937 ! respiratory burst GO:0045730 7 7 0,000 2,988E-03 0,01392156 ! telencephalon cell migration GO:0022029 8 7 0,000 2,988E-03 0,01390381 ! cytokinesis during cell cycle GO:0033205 7 7 0,000 2,988E-03 0,01388609 ! cation:chloride symporter activity GO:0015377 8 7 0,000 2,988E-03 0,01386843 ! RNA cap binding GO:0000339 8 7 0,000 2,988E-03 0,01385081 ! generation of neurons in the forebrain GO:0021872 8 7 0,000 2,988E-03 0,01383323 ! ephrin receptor binding GO:0046875 9 7 0,000 2,988E-03 0,0138157 ! male meiosis I GO:0007141 7 7 0,000 2,988E-03 0,01379821 ! synapsis GO:0007129 7 7 0,000 2,988E-03 0,01378076 GO:0070192|chromosome organization involved in meiosis, ! insulin receptor substrate binding GO:0043560 10 7 0,000 2,988E-03 0,01376336 ! N-terminal protein amino acid acetylation GO:0006474 8 7 0,000 2,988E-03 0,01374601 ! type I transforming growth factor beta receptor binding GO:0034713 8 7 0,000 2,988E-03 0,0137287 ! signal peptide processing GO:0006465 7 7 0,000 2,988E-03 0,01371143 ! regulation of cardiac muscle cell proliferation GO:0060043 8 7 0,000 2,988E-03 0,0136942 ! alpha(1,3)-fucosyltransferase activity GO:0046920 8 7 0,000 2,988E-03 0,01367702 ! macrophage chemotaxis GO:0048246 7 7 0,000 2,988E-03 0,01365988 ! Golgi cisterna membrane GO:0032580 7 7 0,000 2,988E-03 0,01364278 ! neurofilament cytoskeleton GO:0060053 8 7 0,000 2,988E-03 0,01362573 ! positive regulation of receptor-mediated endocytosis GO:0048260 7 7 0,000 2,988E-03 0,01360872 ! smoothened signaling pathway GO:0007224 8 7 0,000 2,988E-03 0,01359175 ! oxidoreductase activity, acting on CH or CH2 groups GO:0016725 7 7 0,000 2,988E-03 0,01357482 ! oxidoreductase activity, oxidizing metal ions GO:0016722 7 7 0,000 2,988E-03 0,01355794 ! cytoplasmic microtubule GO:0005881 7 7 0,000 2,988E-03 0,0135411 ! Arp2/3 protein complex GO:0005885 8 7 0,000 2,988E-03 0,0135243 ! fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331 7 7 0,000 2,988E-03 0,01350754 ! ATPase binding GO:0051117 8 7 0,000 2,988E-03 0,01349082 ! positive regulation of isotype switching GO:0045830 7 7 0,000 2,988E-03 0,01347415 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 2,988E-03 0,01345751 ! positive regulation of gene expression, epigenetic GO:0045815 7 7 0,000 2,988E-03 0,01344092 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 7 0,000 2,988E-03 0,01342437 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 2,988E-03 0,01340785 ! thymic T cell selection GO:0045061 16 7 0,000 2,988E-03 0,01339138 ! transepithelial chloride transport GO:0030321 7 7 0,000 2,988E-03 0,01337495 GO:0070633|transepithelial transport, ! adrenal gland development GO:0030325 7 7 0,000 2,988E-03 0,01335856 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 7 7 0,000 2,988E-03 0,01334221 ! negative regulation of survival gene product expression GO:0008634 9 7 0,000 2,988E-03 0,0133259 ! activation of caspase activity by cytochrome c GO:0008635 7 7 0,000 2,988E-03 0,01330963 ! melanocyte differentiation GO:0030318 8 7 0,000 2,988E-03 0,0132934 ! malate dehydrogenase activity GO:0016615 8 7 0,000 2,988E-03 0,0132772 ! mitochondrial respiratory chain complex assembly GO:0033108 7 7 0,000 2,988E-03 0,01326105 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! DNA secondary structure binding GO:0000217 16 7 0,000 2,988E-03 0,01324494 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor GO:0016653 8 7 0,000 2,988E-03 0,01322886 ! regulation of peptidyl-serine phosphorylation GO:0033135 7 7 0,000 2,988E-03 0,01321283 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 8 7 0,000 2,988E-03 0,01319683 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of granule cell precursor proliferation GO:0021936 7 7 0,000 2,988E-03 0,01318088 GO:0021940|positive regulation of granule cell precursor proliferation, ! V(D)J recombination GO:0033151 8 7 0,000 2,988E-03 0,01316496 ! tetrahydrobiopterin metabolic process GO:0046146 8 7 0,000 2,988E-03 0,01314908 ! vascular endothelial growth factor receptor activity GO:0005021 12 7 0,000 2,988E-03 0,01313323 ! central nervous system neuron axonogenesis GO:0021955 8 7 0,000 2,988E-03 0,01311743 GO:0021952|central nervous system projection neuron axonogenesis, ! oxidoreductase activity, acting on diphenols and related substances as donors GO:0016679 7 7 0,000 2,988E-03 0,01310166 GO:0016681|oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor, GO:0008121|ubiquinol-cytochrome-c reductase activity, ! response to tumor necrosis factor GO:0034612 8 7 0,000 2,988E-03 0,01308594 ! peptidoglycan metabolic process GO:0000270 9 7 0,000 2,988E-03 0,01307025 GO:0009253|peptidoglycan catabolic process, ! response to ATP GO:0033198 7 7 0,000 2,988E-03 0,01305459 ! signal recognition particle, endoplasmic reticulum targeting GO:0005786 8 7 0,000 2,988E-03 0,01303898 GO:0048500|signal recognition particle, ! stereocilium GO:0032420 10 7 0,000 2,988E-03 0,0130234 ! paraxial mesoderm morphogenesis GO:0048340 9 7 0,000 2,988E-03 0,01300786 ! melanosome organization GO:0032438 7 7 0,000 2,988E-03 0,01299235 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 8 7 0,000 2,988E-03 0,01297689 ! mesodermal cell differentiation GO:0048333 9 7 0,000 2,988E-03 0,01296146 GO:0001710|mesodermal cell fate commitment, ! positive regulation of neuroblast proliferation GO:0002052 7 7 0,000 2,988E-03 0,01294606 ! Rac protein signal transduction GO:0016601 7 7 0,000 2,988E-03 0,01293071 ! chondrocyte differentiation GO:0002062 7 7 0,000 2,988E-03 0,01291538 ! guanylate cyclase regulator activity GO:0030249 7 7 0,000 2,988E-03 0,0129001 GO:0010851|cyclase regulator activity, ! intestinal cholesterol absorption GO:0030299 9 7 0,000 2,988E-03 0,01288485 ! negative regulation of specific transcription from RNA polymerase II promoter GO:0010553 8 7 0,000 2,988E-03 0,01286964 ! positive regulation of mitotic cell cycle GO:0045931 7 7 0,000 2,988E-03 0,01285446 ! determination of anterior/posterior axis, embryo GO:0008595 10 7 0,000 2,988E-03 0,01283932 GO:0007350|blastoderm segmentation, GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 8 7 0,000 2,988E-03 0,01282422 ! regulation of vascular endothelial growth factor production GO:0010574 7 7 0,000 2,988E-03 0,01280915 ! Schwann cell differentiation GO:0014037 8 7 0,000 2,988E-03 0,01279411 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 9 7 0,000 2,988E-03 0,01277911 ! lipopolysaccharide biosynthetic process GO:0009103 7 7 0,000 2,988E-03 0,01276415 ! CDP-alcohol phosphatidyltransferase activity GO:0017169 7 7 0,000 2,988E-03 0,01274922 ! vinculin binding GO:0017166 9 7 0,000 2,988E-03 0,01273433 ! intrinsic to mitochondrial outer membrane GO:0031306 7 7 0,000 2,988E-03 0,01271947 ! regulation of collagen metabolic process GO:0010712 8 7 0,000 2,988E-03 0,01270464 ! wound healing, spreading of epidermal cells GO:0035313 7 7 0,000 2,988E-03 0,01268985 ! negative regulation of gliogenesis GO:0014014 8 7 0,000 2,988E-03 0,0126751 GO:0045686|negative regulation of glial cell differentiation, ! translation termination factor activity GO:0008079 7 7 0,000 2,988E-03 0,01266038 GO:0003747|translation release factor activity, ! purine base biosynthetic process GO:0009113 8 7 0,000 2,988E-03 0,01264569 ! cardiac muscle cell development GO:0055013 8 7 0,000 2,988E-03 0,01263104 ! fibrinolysis GO:0042730 9 7 0,000 2,988E-03 0,01261642 ! response to tropane GO:0014073 10 7 0,000 2,988E-03 0,01260183 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 7 7 0,000 2,988E-03 0,01258728 GO:0051904|pigment granule transport, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 8 7 0,000 2,988E-03 0,01257276 ! glycosylceramide metabolic process GO:0006677 7 7 0,000 2,988E-03 0,01255828 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 7 7 0,000 2,988E-03 0,01254383 ! laminin-1 complex GO:0005606 7 7 0,000 2,988E-03 0,01252941 GO:0043256|laminin complex, ! regulation of chondrocyte differentiation GO:0032330 8 7 0,000 2,988E-03 0,01251502 ! positive regulation of immunoglobulin mediated immune response GO:0002891 7 7 0,000 2,988E-03 0,01250067 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of lipid transport GO:0032370 8 7 0,000 2,988E-03 0,01248635 ! regulation of cell division GO:0051302 7 7 0,000 2,988E-03 0,01247206 ! holo TFIIH complex GO:0005675 7 7 0,000 2,988E-03 0,01245781 ! mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 10 7 0,000 2,988E-03 0,01244359 ! chitinase activity GO:0004568 7 7 0,000 2,988E-03 0,0124294 GO:0006046|N-acetylglucosamine catabolic process, GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! regulation of immune response to tumor cell GO:0002837 8 7 0,000 2,988E-03 0,01241524 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! U12-type spliceosomal complex GO:0005689 8 7 0,000 2,988E-03 0,01240112 ! regulation of respiratory burst GO:0060263 8 7 0,000 2,988E-03 0,01238703 ! prophase GO:0051324 8 7 0,000 2,988E-03 0,01237297 ! peptidyl-histidine modification GO:0018202 8 7 0,000 2,988E-03 0,01235894 ! centriolar satellite GO:0034451 10 7 0,000 2,988E-03 0,01234494 ! BBSome GO:0034464 7 7 0,000 2,988E-03 0,01233098 ! glycerophosphodiester phosphodiesterase activity GO:0008889 7 7 0,000 2,988E-03 0,01231704 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 2,988E-03 0,01230314 ! negative regulation of lymphocyte differentiation GO:0045620 8 7 0,000 2,988E-03 0,01228927 ! negative regulation of transmission of nerve impulse GO:0051970 7 7 0,000 2,988E-03 0,01227543 ! regulation of synaptic transmission, glutamatergic GO:0051966 8 7 0,000 2,988E-03 0,01226162 ! regulation of synaptogenesis GO:0051963 7 7 0,000 2,988E-03 0,01224785 ! serine family amino acid catabolic process GO:0009071 7 7 0,000 2,988E-03 0,0122341 ! MHC class I peptide loading complex GO:0042824 7 7 0,000 2,988E-03 0,01222039 ! glycolipid catabolic process GO:0019377 7 7 0,000 2,988E-03 0,0122067 GO:0046479|glycosphingolipid catabolic process, ! racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016857 8 7 0,000 2,988E-03 0,01219305 ! circadian behavior GO:0048512 9 7 0,000 2,988E-03 0,01217942 ! dorsal/ventral axis specification GO:0009950 7 7 0,000 2,988E-03 0,01216583 ! ligase activity, forming carbon-carbon bonds GO:0016885 9 7 0,000 2,988E-03 0,01215227 ! striatum development GO:0021756 7 7 0,000 2,988E-03 0,01213874 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0016812 8 7 0,000 2,988E-03 0,01212523 ! triglyceride biosynthetic process GO:0019432 7 7 0,000 2,988E-03 0,01211176 ! cerebellar Purkinje cell layer development GO:0021680 7 7 0,000 2,988E-03 0,01209832 ! carbon-nitrogen lyase activity GO:0016840 7 7 0,000 2,988E-03 0,01208491 ! dystroglycan complex GO:0016011 9 7 0,000 2,988E-03 0,01207152 ! negative regulation of calcium ion transport GO:0051926 7 7 0,000 2,988E-03 0,01205817 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 8 7 0,000 2,988E-03 0,01204484 ! peroxiredoxin activity GO:0051920 7 7 0,000 2,988E-03 0,01203155 ! muscle adaptation GO:0043500 7 7 0,000 2,988E-03 0,01201828 ! regulation of muscle adaptation GO:0043502 7 7 0,000 2,988E-03 0,01200505 ! diacylglycerol metabolic process GO:0046339 7 7 0,000 2,988E-03 0,01199184 ! lysogeny GO:0030069 7 7 0,000 2,988E-03 0,01197866 GO:0019047|provirus integration, ! protein insertion into membrane GO:0051205 7 7 0,000 2,988E-03 0,01196552 ! sequestering of metal ion GO:0051238 9 7 0,000 2,988E-03 0,0119524 ! membrane attack complex GO:0005579 7 7 0,000 2,988E-03 0,0119393 ! fibrinogen complex GO:0005577 7 7 0,000 2,988E-03 0,01192624 ! metallo-sulfur cluster assembly GO:0031163 9 7 0,000 2,988E-03 0,01191321 GO:0016226|iron-sulfur cluster assembly, ! extracellular matrix structural constituent conferring compression resistance GO:0030021 8 7 0,000 2,988E-03 0,0119002 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 8 7 0,000 2,988E-03 0,01188722 ! GABA receptor binding GO:0050811 8 7 0,000 2,988E-03 0,01187428 ! sheet-forming collagen GO:0030935 7 7 0,000 2,988E-03 0,01186135 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 8 7 0,000 2,988E-03 0,01184846 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 8 7 0,000 2,988E-03 0,0118356 ! sphingomyelin phosphodiesterase activity GO:0004767 9 7 0,000 2,988E-03 0,01182276 ! regulation of epithelial cell differentiation GO:0030856 7 7 0,000 2,988E-03 0,01180995 ! 7S RNA binding GO:0008312 8 7 0,000 2,988E-03 0,01179717 ! positive regulation of lipid catabolic process GO:0050996 7 7 0,000 2,988E-03 0,01178442 ! protein phosphorylated amino acid binding GO:0045309 9 7 0,000 2,988E-03 0,01177169 ! 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 8 7 0,000 2,988E-03 0,01175899 ! regulation of long-term neuronal synaptic plasticity GO:0048169 17 7 0,000 2,988E-03 0,01174632 ! Golgi to endosome transport GO:0006895 8 7 0,000 2,988E-03 0,01173368 ! glucocorticoid receptor signaling pathway GO:0042921 7 7 0,000 2,988E-03 0,01172106 GO:0031958|corticosteroid receptor signaling pathway, ! succinate metabolic process GO:0006105 7 7 0,000 2,988E-03 0,01170847 ! fibril GO:0043205 7 7 0,000 2,988E-03 0,01169591 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 2,988E-03 0,01168337 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 2,988E-03 0,01167086 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 7 0,000 2,988E-03 0,01165838 ! sensory perception of bitter taste GO:0050913 7 7 0,000 2,988E-03 0,01164592 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 2,988E-03 0,01163349 ! posttranscriptional gene silencing by RNA GO:0035194 9 7 0,000 2,988E-03 0,01162109 GO:0016441|posttranscriptional gene silencing, ! cell division site part GO:0032155 9 7 0,000 2,988E-03 0,01160872 GO:0032153|cell division site, ! laminin binding GO:0043236 7 7 0,000 2,988E-03 0,01159637 ! equilibrioception GO:0050957 10 7 0,000 2,988E-03 0,01158404 ! G-protein coupled receptor kinase activity GO:0004703 9 7 0,000 2,988E-03 0,01157175 ! titin binding GO:0031432 7 7 0,000 2,988E-03 0,01155947 ! chemosensory behavior GO:0007635 9 7 0,000 2,988E-03 0,01154723 ! regulation of response to extracellular stimulus GO:0032104 7 7 0,000 2,988E-03 0,01153501 GO:0032107|regulation of response to nutrient levels, ! plasma lipoprotein particle assembly GO:0034377 7 7 0,000 2,988E-03 0,01152282 ! cobalamin binding GO:0031419 7 7 0,000 2,988E-03 0,01151065 ! sodium:phosphate symporter activity GO:0005436 8 7 0,000 2,988E-03 0,01149851 ! response to axon injury GO:0048678 9 7 0,000 2,988E-03 0,01148639 ! regulation of activin receptor signaling pathway GO:0032925 7 7 0,000 2,988E-03 0,0114743 ! non-membrane spanning protein tyrosine phosphatase activity GO:0004726 8 7 0,000 2,988E-03 0,01146223 ! F-actin capping protein complex GO:0008290 8 7 0,000 2,988E-03 0,01145019 ! sphingoid biosynthetic process GO:0046520 7 7 0,000 2,988E-03 0,01143818 ! cGMP-mediated signaling GO:0019934 8 7 0,000 2,988E-03 0,01142619 ! nerve growth factor receptor signaling pathway GO:0048011 8 7 0,000 2,988E-03 0,01141422 ! cAMP-dependent protein kinase activity GO:0004691 7 7 0,000 2,988E-03 0,01140228 ! senescence GO:0010149 8 7 0,000 2,988E-03 0,01139037 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 10 7 0,000 2,988E-03 0,01137848 ! nuclear localization sequence binding GO:0008139 8 7 0,000 2,988E-03 0,01136662 ! galactose metabolic process GO:0006012 8 7 0,000 2,988E-03 0,01135478 ! vesicle fusion GO:0006906 8 7 0,000 2,988E-03 0,01134296 ! maintenance of protein location in nucleus GO:0051457 7 7 0,000 2,988E-03 0,01133117 ! intracellular pH reduction GO:0051452 7 7 0,000 2,988E-03 0,0113194 ! glycerol ether catabolic process GO:0044269 16 7 0,000 2,988E-03 0,01130766 GO:0046461|neutral lipid catabolic process, GO:0046464|acylglycerol catabolic process, ! neurotransmitter catabolic process GO:0042135 9 7 0,000 2,988E-03 0,01129594 ! ruffle organization GO:0031529 9 7 0,000 2,988E-03 0,01128425 ! nucleoside transport GO:0015858 8 7 0,000 2,988E-03 0,01127258 ! attachment of GPI anchor to protein GO:0016255 8 7 0,000 2,988E-03 0,01126093 ! inclusion body GO:0016234 7 7 0,000 2,988E-03 0,01124931 ! Cajal body GO:0015030 7 7 0,000 2,988E-03 0,01123772 ! H4/H2A histone acetyltransferase complex GO:0043189 9 7 0,000 2,988E-03 0,01122614 ! rRNA modification GO:0000154 7 7 0,000 2,988E-03 0,01121459 ! PcG protein complex GO:0031519 7 7 0,000 2,988E-03 0,01120307 ! phosphatidate phosphatase activity GO:0008195 7 7 0,000 2,988E-03 0,01119157 ! NAD-dependent protein deacetylase activity GO:0034979 7 7 0,000 2,988E-03 0,01118009 GO:0017136|NAD-dependent histone deacetylase activity, ! spindle checkpoint GO:0031577 7 7 0,000 2,988E-03 0,01116863 ! apolipoprotein binding GO:0034185 9 7 0,000 2,988E-03 0,0111572 ! G1 DNA damage checkpoint GO:0031571 7 7 0,000 2,988E-03 0,01114579 ! segment specification GO:0007379 9 7 0,000 2,988E-03 0,01113441 ! pronucleus GO:0045120 25 7 0,000 2,988E-03 0,01112305 ! bile acid:sodium symporter activity GO:0008508 9 7 0,000 2,988E-03 0,01111171 ! Rac GTPase activator activity GO:0030675 9 7 0,000 2,988E-03 0,01110039 ! regulation of DNA repair GO:0006282 19 7 0,000 2,988E-03 0,0110891 ! preribosome GO:0030684 7 7 0,000 2,988E-03 0,01107783 ! DNA topological change GO:0006265 7 7 0,000 2,988E-03 0,01106658 ! DNA ligation GO:0006266 8 7 0,000 2,988E-03 0,01105536 ! hair follicle maturation GO:0048820 8 7 0,000 2,988E-03 0,01104416 ! renal water homeostasis GO:0003091 7 7 0,000 2,988E-03 0,01103298 ! clathrin-coated endocytic vesicle membrane GO:0030669 7 7 0,000 2,988E-03 0,01102182 ! positive regulation of interleukin-6 production GO:0032755 7 7 0,000 2,988E-03 0,01101069 ! interleukin-1 receptor activity GO:0004908 8 7 0,000 2,988E-03 0,01099958 ! positive regulation of tumor necrosis factor production GO:0032760 7 7 0,000 2,988E-03 0,01098849 ! positive regulation of monooxygenase activity GO:0032770 7 7 0,000 2,988E-03 0,01097743 ! inositol trisphosphate 3-kinase activity GO:0008440 8 7 0,000 2,988E-03 0,01096638 ! phosphofructokinase activity GO:0008443 7 7 0,000 2,988E-03 0,01095536 ! gap junction channel activity GO:0005243 8 7 0,000 2,988E-03 0,01094436 ! 3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 10 7 0,000 2,988E-03 0,01093338 ! histone methylation GO:0016571 7 7 0,000 2,988E-03 0,01092243 ! positive regulation of interferon-gamma production GO:0032729 7 7 0,000 2,988E-03 0,0109115 ! negative regulation of tumor necrosis factor production GO:0032720 9 7 0,000 2,988E-03 0,01090058 ! mitochondrion morphogenesis GO:0070584 9 7 0,000 2,988E-03 0,01088969 ! muscle cell proliferation GO:0033002 8 7 0,000 2,988E-03 0,01087883 ! transcription termination GO:0006353 9 7 0,000 2,988E-03 0,01086798 ! regulation of transcription from RNA polymerase III promoter GO:0006359 16 7 0,000 2,988E-03 0,01085716 ! sodium:amino acid symporter activity GO:0005283 7 7 0,000 2,988E-03 0,01084635 ! cytidylyltransferase activity GO:0070567 8 7 0,000 2,988E-03 0,01083557 ! monolayer-surrounded lipid storage body GO:0012511 7 7 0,000 2,988E-03 0,01082481 ! ATP-dependent peptidase activity GO:0004176 7 7 0,000 2,988E-03 0,01081407 ! salivary gland development GO:0007431 7 7 0,000 2,988E-03 0,01080335 ! glucosidase activity GO:0015926 8 7 0,000 2,988E-03 0,01079266 ! NuRD complex GO:0016581 8 7 0,000 2,988E-03 0,01078198 ! negative regulation of nuclear division GO:0051784 7 7 0,000 2,988E-03 0,01077133 GO:0045839|negative regulation of mitosis, ! ATP-gated cation channel activity GO:0004931 9 7 0,000 2,988E-03 0,0107607 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 7 7 0,000 2,988E-03 0,01075008 ! response to redox state GO:0051775 8 7 0,000 2,988E-03 0,01073949 ! positive regulation of leukocyte chemotaxis GO:0002690 7 7 0,000 2,988E-03 0,01072892 GO:0002688|regulation of leukocyte chemotaxis, ! melanin biosynthetic process GO:0042438 8 7 0,000 2,988E-03 0,01071837 ! procollagen-proline dioxygenase activity GO:0019798 7 7 0,000 2,988E-03 0,01070784 ! actin monomer binding GO:0003785 7 7 0,000 2,988E-03 0,01069734 ! protein prenyltransferase activity GO:0008318 8 7 0,000 2,988E-03 0,01068685 ! endosome to lysosome transport GO:0008333 7 7 0,000 2,988E-03 0,01067638 ! regulation of Rac protein signal transduction GO:0035020 17 7 0,000 2,988E-03 0,01066593 ! germ cell migration GO:0008354 7 7 0,000 2,988E-03 0,01065551 ! fibroblast growth factor receptor binding GO:0005104 8 7 0,000 2,988E-03 0,0106451 ! negative regulation of organic acid transport GO:0032891 8 7 0,000 2,988E-03 0,01063472 ! CoA-ligase activity GO:0016405 8 7 0,000 2,988E-03 0,01062435 ! positive regulation of NF-kappaB import into nucleus GO:0042346 8 7 0,000 2,988E-03 0,01061401 ! interferon-alpha/beta receptor binding GO:0005132 7 7 0,000 2,988E-03 0,01060368 ! embryonic heart tube development GO:0035050 8 7 0,000 2,988E-03 0,01059338 ! dihydropyridine-sensitive calcium channel activity GO:0015270 10 7 0,000 2,988E-03 0,01058309 ! kainate selective glutamate receptor activity GO:0015277 8 7 0,000 2,988E-03 0,01057283 ! negative regulation of nucleotide metabolic process GO:0045980 8 7 0,000 2,988E-03 0,01056258 ! amiloride-sensitive sodium channel activity GO:0015280 7 7 0,000 2,988E-03 0,01055236 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 2,988E-03 0,01054215 ! adenylate kinase activity GO:0004017 8 7 0,000 2,988E-03 0,01053197 ! negative regulation of immune effector process GO:0002698 13 7 0,000 2,988E-03 0,0105218 ! C-X-C chemokine receptor activity GO:0016494 7 7 0,000 2,988E-03 0,01051165 ! vacuolar proton-transporting V-type ATPase complex GO:0016471 7 7 0,000 2,988E-03 0,01050153 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 10 8 0,000 3,414E-03 0,01198795 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 9 8 0,000 3,414E-03 0,01197642 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 8 0,000 3,414E-03 0,01196492 ! chaperone mediated protein folding requiring cofactor GO:0051085 8 8 0,000 3,414E-03 0,01195344 ! negative regulation of lipid biosynthetic process GO:0051055 18 8 0,000 3,414E-03 0,01194198 ! regulation of cellular amine metabolic process GO:0033238 10 8 0,000 3,414E-03 0,01193054 ! proteasome regulatory particle GO:0005838 8 8 0,000 3,414E-03 0,01191912 ! SMAD protein complex assembly GO:0007183 10 8 0,000 3,414E-03 0,01190773 ! regulation of smooth muscle cell migration GO:0014910 11 8 0,000 3,414E-03 0,01189635 ! protein self-association GO:0043621 8 8 0,000 3,414E-03 0,011885 ! glycine hydroxymethyltransferase activity GO:0004372 9 8 0,000 3,414E-03 0,01187367 ! sodium:potassium-exchanging ATPase complex GO:0005890 10 8 0,000 3,414E-03 0,01186236 ! neurotransmitter uptake GO:0001504 8 8 0,000 3,414E-03 0,01185108 ! regulation of activated T cell proliferation GO:0046006 9 8 0,000 3,414E-03 0,01183981 ! guanylate cyclase activity GO:0004383 9 8 0,000 3,414E-03 0,01182857 ! troponin complex GO:0005861 8 8 0,000 3,414E-03 0,01181735 ! eukaryotic translation initiation factor 3 complex GO:0005852 8 8 0,000 3,414E-03 0,01180614 ! tachykinin receptor signaling pathway GO:0007217 8 8 0,000 3,414E-03 0,01179496 ! negative regulation of muscle cell differentiation GO:0051148 10 8 0,000 3,414E-03 0,0117838 ! microtubule bundle formation GO:0001578 8 8 0,000 3,414E-03 0,01177267 ! middle ear morphogenesis GO:0042474 10 8 0,000 3,414E-03 0,01176155 ! ganglioside metabolic process GO:0001573 8 8 0,000 3,414E-03 0,01175045 ! regulation of mesenchymal cell proliferation GO:0010464 9 8 0,000 3,414E-03 0,01173938 GO:0002053|positive regulation of mesenchymal cell proliferation, ! ovulation from ovarian follicle GO:0001542 8 8 0,000 3,414E-03 0,01172833 ! ciliary or flagellar motility GO:0001539 8 8 0,000 3,414E-03 0,01171729 ! pathogenesis GO:0009405 8 8 0,000 3,414E-03 0,01170628 ! pH reduction GO:0045851 9 8 0,000 3,414E-03 0,01169529 ! small protein activating enzyme activity GO:0008641 10 8 0,000 3,414E-03 0,01168432 ! ribonucleoside triphosphate catabolic process GO:0009203 8 8 0,000 3,414E-03 0,01167337 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 8 8 0,000 3,414E-03 0,01166244 ! hemoglobin metabolic process GO:0020027 8 8 0,000 3,414E-03 0,01165153 ! regulation of S phase of mitotic cell cycle GO:0007090 8 8 0,000 3,414E-03 0,01164064 ! arginine catabolic process GO:0006527 9 8 0,000 3,414E-03 0,01162977 ! T-tubule GO:0030315 9 8 0,000 3,414E-03 0,01161892 ! regulation of defense response to virus by virus GO:0050690 17 8 0,000 3,414E-03 0,01160809 ! histidine catabolic process GO:0006548 8 8 0,000 3,414E-03 0,01159728 GO:0009077|histidine family amino acid catabolic process, ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GO:0016624 8 8 0,000 3,414E-03 0,01158649 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 8 0,000 3,414E-03 0,01157573 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor GO:0016634 10 8 0,000 3,414E-03 0,01156498 ! proline metabolic process GO:0006560 10 8 0,000 3,414E-03 0,01155425 ! L-serine metabolic process GO:0006563 9 8 0,000 3,414E-03 0,01154354 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor GO:0016668 8 8 0,000 3,414E-03 0,01153285 ! melanosome membrane GO:0033162 9 8 0,000 3,414E-03 0,01152218 GO:0045009|chitosome, ! phosphagen metabolic process GO:0006599 8 8 0,000 3,414E-03 0,01151154 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 8 8 0,000 3,414E-03 0,01150091 ! pericentriolar material GO:0000242 9 8 0,000 3,414E-03 0,0114903 ! reverse cholesterol transport GO:0043691 8 8 0,000 3,414E-03 0,01147971 ! tumor necrosis factor receptor activity GO:0005031 8 8 0,000 3,414E-03 0,01146914 ! melanin metabolic process GO:0006582 10 8 0,000 3,414E-03 0,01145858 ! proton-transporting V-type ATPase, V1 domain GO:0033180 8 8 0,000 3,414E-03 0,01144805 ! phasic smooth muscle contraction GO:0014821 9 8 0,000 3,414E-03 0,01143754 ! Golgi lumen GO:0005796 8 8 0,000 3,414E-03 0,01142705 ! positive regulation of endothelial cell migration GO:0010595 9 8 0,000 3,414E-03 0,01141657 ! regulation of Cdc42 protein signal transduction GO:0032489 9 8 0,000 3,414E-03 0,01140612 GO:0043088|regulation of Cdc42 GTPase activity, ! methyltransferase complex GO:0034708 8 8 0,000 3,414E-03 0,01139568 GO:0035097|histone methyltransferase complex, ! paraxial mesoderm development GO:0048339 10 8 0,000 3,414E-03 0,01138527 ! stereocilium bundle GO:0032421 11 8 0,000 3,414E-03 0,01137487 ! forebrain cell migration GO:0021885 9 8 0,000 3,414E-03 0,01136449 ! peptidyl-threonine phosphorylation GO:0018107 11 8 0,000 3,414E-03 0,01135413 ! osteoblast development GO:0002076 11 8 0,000 3,414E-03 0,01134379 ! retinoic acid metabolic process GO:0042573 8 8 0,000 3,414E-03 0,01133347 ! retinol metabolic process GO:0042572 8 8 0,000 3,414E-03 0,01132317 ! negative regulation of muscle contraction GO:0045932 10 8 0,000 3,414E-03 0,01131288 ! structural constituent of epidermis GO:0030280 9 8 0,000 3,414E-03 0,01130262 ! clathrin binding GO:0030276 10 8 0,000 3,414E-03 0,01129237 ! phosphatidylinositol bisphosphate phosphatase activity GO:0034593 9 8 0,000 3,414E-03 0,01128214 ! chondroitin sulfate biosynthetic process GO:0030206 9 8 0,000 3,414E-03 0,01127193 GO:0030204|chondroitin sulfate metabolic process, ! sodium:dicarboxylate symporter activity GO:0017153 9 8 0,000 3,414E-03 0,01126174 ! motor axon guidance GO:0008045 8 8 0,000 3,414E-03 0,01125156 ! protein targeting to vacuole GO:0006623 8 8 0,000 3,414E-03 0,01124141 ! negative regulation of axonogenesis GO:0050771 12 8 0,000 3,414E-03 0,01123127 ! peptidyl-asparagine modification GO:0018196 8 8 0,000 3,414E-03 0,01122115 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! melanosome localization GO:0032400 8 8 0,000 3,414E-03 0,01121105 GO:0032401|establishment of melanosome localization, GO:0051875|pigment granule localization, GO:0051905|establishment of pigment granule localization, ! mismatch repair complex binding GO:0032404 10 8 0,000 3,414E-03 0,01120097 ! nucleoside diphosphate metabolic process GO:0009132 9 8 0,000 3,414E-03 0,01119091 ! protein-lipid complex assembly GO:0065005 8 8 0,000 3,414E-03 0,01118086 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 9 8 0,000 3,414E-03 0,01117084 ! phosphoinositide 3-kinase cascade GO:0014065 8 8 0,000 3,414E-03 0,01116083 ! regulation of dopamine secretion GO:0014059 9 8 0,000 3,414E-03 0,01115083 ! regulation of protein kinase B signaling cascade GO:0051896 9 8 0,000 3,414E-03 0,01114086 ! cranial nerve morphogenesis GO:0021602 9 8 0,000 3,414E-03 0,0111309 ! subpallium development GO:0021544 8 8 0,000 3,414E-03 0,01112097 ! icosanoid secretion GO:0032309 10 8 0,000 3,414E-03 0,01111105 GO:0050482|arachidonic acid secretion, ! negative regulation of oxidoreductase activity GO:0051354 8 8 0,000 3,414E-03 0,01110114 ! regulation of DNA replication initiation GO:0030174 8 8 0,000 3,414E-03 0,01109126 ! negative regulation of cytokine secretion GO:0050710 10 8 0,000 3,414E-03 0,01108139 ! dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0004579 8 8 0,000 3,414E-03 0,01107154 ! exodeoxyribonuclease activity GO:0004529 18 8 0,000 3,414E-03 0,01106171 GO:0016895|exodeoxyribonuclease activity, producing 5'-phosphomonoesters, ! ER to Golgi transport vesicle GO:0030134 9 8 0,000 3,414E-03 0,01105189 ! nucleotide diphosphatase activity GO:0004551 9 8 0,000 3,414E-03 0,01104209 ! regulation of myoblast differentiation GO:0045661 9 8 0,000 3,414E-03 0,01103231 ! ubiquinone metabolic process GO:0006743 9 8 0,000 3,414E-03 0,01102255 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! neuromuscular process controlling posture GO:0050884 8 8 0,000 3,414E-03 0,0110128 ! multicellular organismal water homeostasis GO:0050891 8 8 0,000 3,414E-03 0,01100308 ! branched chain family amino acid catabolic process GO:0009083 9 8 0,000 3,414E-03 0,01099336 ! Wnt receptor activity GO:0042813 11 8 0,000 3,414E-03 0,01098367 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses GO:0016861 8 8 0,000 3,414E-03 0,01097399 ! leukocyte mediated cytotoxicity GO:0001909 10 8 0,000 3,414E-03 0,01096433 ! detection of calcium ion GO:0005513 9 8 0,000 3,414E-03 0,01095469 ! negative regulation of glucose import GO:0046325 9 8 0,000 3,414E-03 0,01094506 ! blastocyst growth GO:0001832 8 8 0,000 3,414E-03 0,01093545 ! regulation of fibrinolysis GO:0051917 8 8 0,000 3,414E-03 0,01092586 ! negative regulation of telomere maintenance GO:0032205 9 8 0,000 3,414E-03 0,01091629 ! cerebellar cortex formation GO:0021697 9 8 0,000 3,414E-03 0,01090673 ! complement binding GO:0001848 11 8 0,000 3,414E-03 0,01089718 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 8 0,000 3,414E-03 0,01088766 ! negative regulation of blood vessel endothelial cell migration GO:0043537 9 8 0,000 3,414E-03 0,01087815 ! amino sugar catabolic process GO:0046348 8 8 0,000 3,414E-03 0,01086866 GO:0006043|glucosamine catabolic process, ! FK506 binding GO:0005528 9 8 0,000 3,414E-03 0,01085918 GO:0005527|macrolide binding, ! dipeptidase activity GO:0016805 8 8 0,000 3,414E-03 0,01084972 ! positive regulation of amine transport GO:0051954 9 8 0,000 3,414E-03 0,01084028 ! release of sequestered calcium ion into cytosol GO:0051209 13 8 0,000 3,414E-03 0,01083085 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, ! B cell receptor signaling pathway GO:0050853 13 8 0,000 3,414E-03 0,01082144 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 3,414E-03 0,01081205 ! Golgi transport complex GO:0017119 8 8 0,000 3,414E-03 0,01080267 ! positive regulation of protein ubiquitination GO:0031398 17 8 0,000 3,414E-03 0,01079331 ! GDP binding GO:0019003 9 8 0,000 3,414E-03 0,01078397 ! positive regulation of glucose metabolic process GO:0010907 8 8 0,000 3,414E-03 0,01077464 ! prostate gland development GO:0030850 17 8 0,000 3,414E-03 0,01076533 ! DNA synthesis during DNA repair GO:0000731 19 8 0,000 3,414E-03 0,01075603 ! nitric-oxide synthase binding GO:0050998 9 8 0,000 3,414E-03 0,01074675 ! phosphate transport GO:0006817 9 8 0,000 3,414E-03 0,01073748 ! cellular copper ion homeostasis GO:0006878 8 8 0,000 3,414E-03 0,01072824 ! oligopeptide transport GO:0006857 8 8 0,000 3,414E-03 0,010719 GO:0015198|oligopeptide transporter activity, ! pigment cell differentiation GO:0050931 9 8 0,000 3,414E-03 0,01070979 ! 5'-nucleotidase activity GO:0008253 8 8 0,000 3,414E-03 0,01070059 ! oligosaccharyltransferase complex GO:0008250 8 8 0,000 3,414E-03 0,0106914 ! lipoprotein transport GO:0042953 9 8 0,000 3,414E-03 0,01068223 ! estrogen metabolic process GO:0008210 8 8 0,000 3,414E-03 0,01067308 ! nucleocytoplasmic transporter activity GO:0005487 8 8 0,000 3,414E-03 0,01066394 ! glucocorticoid metabolic process GO:0008211 8 8 0,000 3,414E-03 0,01065482 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 8 8 0,000 3,414E-03 0,01064571 ! T-helper 1 type immune response GO:0042088 8 8 0,000 3,414E-03 0,01063662 ! amyloid precursor protein catabolic process GO:0042987 10 8 0,000 3,414E-03 0,01062754 ! response to amphetamine GO:0001975 11 8 0,000 3,414E-03 0,01061848 ! mechanosensory behavior GO:0007638 8 8 0,000 3,414E-03 0,01060944 ! detection of chemical stimulus involved in sensory perception GO:0050907 8 8 0,000 3,414E-03 0,01060041 ! DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 8 8 0,000 3,414E-03 0,0105914 ! C-X-C chemokine binding GO:0019958 8 8 0,000 3,414E-03 0,0105824 ! two-component signal transduction system (phosphorelay) GO:0000160 9 8 0,000 3,414E-03 0,01057341 ! glycerolipid catabolic process GO:0046503 17 8 0,000 3,414E-03 0,01056445 ! spinal cord dorsal/ventral patterning GO:0021513 10 8 0,000 3,414E-03 0,01055549 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 9 8 0,000 3,414E-03 0,01054656 ! inositol phosphate-mediated signaling GO:0048016 9 8 0,000 3,414E-03 0,01053763 ! insulin-like growth factor receptor signaling pathway GO:0048009 8 8 0,000 3,414E-03 0,01052873 ! pigment granule organization GO:0048753 9 8 0,000 3,414E-03 0,01051983 ! GTP-dependent protein binding GO:0030742 11 8 0,000 3,414E-03 0,01051096 ! myeloid leukocyte mediated immunity GO:0002444 8 8 0,000 3,414E-03 0,01050209 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 8 0,000 3,414E-03 0,01049325 ! regulation of pigmentation during development GO:0048070 11 8 0,000 3,414E-03 0,01048441 ! macrophage activation GO:0042116 8 8 0,000 3,414E-03 0,01047559 ! poly(A) RNA binding GO:0008143 8 8 0,000 3,414E-03 0,01046679 ! positive regulation of insulin secretion GO:0032024 10 8 0,000 3,414E-03 0,010458 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 18 8 0,000 3,414E-03 0,01044923 ! asymmetric protein localization GO:0008105 9 8 0,000 3,414E-03 0,01044047 ! nucleotide-sugar transmembrane transporter activity GO:0005338 8 8 0,000 3,414E-03 0,01043173 ! neurotrophin binding GO:0043121 10 8 0,000 3,414E-03 0,010423 ! nucleoside transmembrane transporter activity GO:0005337 9 8 0,000 3,414E-03 0,01041428 ! positive regulation of multicellular organismal metabolic process GO:0044253 9 8 0,000 3,414E-03 0,01040558 ! phagocytosis, engulfment GO:0006911 10 8 0,000 3,414E-03 0,0103969 ! UDP-glucosyltransferase activity GO:0035251 8 8 0,000 3,414E-03 0,01038823 ! neurotransmitter biosynthetic process GO:0042136 9 8 0,000 3,414E-03 0,01037957 ! UV protection GO:0009650 9 8 0,000 3,414E-03 0,01037093 ! peptidyl-proline dioxygenase activity GO:0031543 8 8 0,000 3,414E-03 0,0103623 ! eukaryotic translation initiation factor 4F complex GO:0016281 10 8 0,000 3,414E-03 0,01035368 ! glutathione peroxidase activity GO:0004602 17 8 0,000 3,414E-03 0,01034508 ! acyl-CoA thioesterase activity GO:0016291 10 8 0,000 3,414E-03 0,0103365 ! ATP-binding cassette (ABC) transporter complex GO:0043190 8 8 0,000 3,414E-03 0,01032793 ! ferric iron binding GO:0008199 9 8 0,000 3,414E-03 0,01031937 ! response to UV-B GO:0010224 10 8 0,000 3,414E-03 0,01031083 ! intermediate filament organization GO:0045109 8 8 0,000 3,414E-03 0,0103023 ! protein-glutamine gamma-glutamyltransferase activity GO:0003810 8 8 0,000 3,414E-03 0,01029379 ! cellular extravasation GO:0045123 9 8 0,000 3,414E-03 0,01028529 ! skeletal muscle contraction GO:0003009 8 8 0,000 3,414E-03 0,0102768 ! positive regulation of cytokine production during immune response GO:0002720 8 8 0,000 3,414E-03 0,01026833 ! regulation of fatty acid biosynthetic process GO:0042304 17 8 0,000 3,414E-03 0,01025987 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 3,414E-03 0,01025143 ! antigen processing and presentation of endogenous antigen GO:0019883 8 8 0,000 3,414E-03 0,01024299 ! positive regulation of systemic arterial blood pressure GO:0003084 10 8 0,000 3,414E-03 0,01023458 ! negative regulation of systemic arterial blood pressure GO:0003085 9 8 0,000 3,414E-03 0,01022618 ! respiratory chain complex IV assembly GO:0008535 8 8 0,000 3,414E-03 0,01021779 ! erythrocyte development GO:0048821 9 8 0,000 3,414E-03 0,01020941 ! regulation of interleukin-10 production GO:0032653 8 8 0,000 3,414E-03 0,01020105 ! ribosome assembly GO:0042255 8 8 0,000 3,414E-03 0,0101927 ! postreplication repair GO:0006301 19 8 0,000 3,414E-03 0,01018437 ! gamma-tubulin binding GO:0043015 8 8 0,000 3,414E-03 0,01017605 ! NADPH oxidase complex GO:0043020 8 8 0,000 3,414E-03 0,01016774 ! mRNA cleavage GO:0006379 9 8 0,000 3,414E-03 0,01015945 ! UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity GO:0008499 9 8 0,000 3,414E-03 0,01015117 ! opioid receptor activity GO:0004985 8 8 0,000 3,414E-03 0,0101429 ! zymogen activation GO:0031638 9 8 0,000 3,414E-03 0,01013465 ! coenzyme A metabolic process GO:0015936 8 8 0,000 3,414E-03 0,01012641 ! cellular metabolic compound salvage GO:0043094 11 8 0,000 3,414E-03 0,01011818 ! costamere GO:0043034 8 8 0,000 3,414E-03 0,01010997 ! inositol trisphosphate kinase activity GO:0051766 9 8 0,000 3,414E-03 0,01010177 ! positive regulation of acute inflammatory response GO:0002675 8 8 0,000 3,414E-03 0,01009358 ! sarcomere organization GO:0045214 9 8 0,000 3,414E-03 0,01008541 ! wide pore channel activity GO:0022829 9 8 0,000 3,414E-03 0,01007725 ! ligand-regulated transcription factor activity GO:0003706 10 8 0,000 3,414E-03 0,0100691 ! RNA polymerase III transcription factor activity GO:0003709 8 8 0,000 3,414E-03 0,01006097 ! hormone catabolic process GO:0042447 9 8 0,000 3,414E-03 0,01005285 ! mRNA 3'-UTR binding GO:0003730 9 8 0,000 3,414E-03 0,01004474 ! cGMP biosynthetic process GO:0006182 9 8 0,000 3,414E-03 0,01003665 ! lysozyme activity GO:0003796 10 8 0,000 3,414E-03 0,01002857 ! death receptor binding GO:0005123 8 8 0,000 3,414E-03 0,0100205 ! protein modification by small protein removal GO:0070646 9 8 0,000 3,414E-03 0,01001245 ! adult feeding behavior GO:0008343 9 8 0,000 3,414E-03 0,0100044 ! microtubule basal body GO:0005932 8 8 0,000 3,414E-03 9,996E-03 ! pyrimidine nucleotide catabolic process GO:0006244 8 8 0,000 3,414E-03 9,988E-03 ! interleukin-1 receptor binding GO:0005149 9 8 0,000 3,414E-03 9,98E-03 ! calcium-release channel activity GO:0015278 8 8 0,000 3,414E-03 9,972E-03 ! positive regulation of smooth muscle contraction GO:0045987 9 8 0,000 3,414E-03 9,964E-03 ! behavioral response to nicotine GO:0035095 9 8 0,000 3,414E-03 9,956E-03 ! aldehyde dehydrogenase (NAD) activity GO:0004029 9 8 0,000 3,414E-03 9,948E-03 ! adenosine deaminase activity GO:0004000 8 8 0,000 3,414E-03 9,941E-03 ! NAD biosynthetic process GO:0009435 9 8 0,000 3,414E-03 9,933E-03 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 10 9 0,000 3,84E-03 0,01116319 ! positive regulation of glycogen biosynthetic process GO:0045725 9 9 0,000 3,84E-03 0,0111543 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 10 9 0,000 3,84E-03 0,01114542 ! sodium:hydrogen antiporter activity GO:0015385 9 9 0,000 3,84E-03 0,01113656 GO:0005451|monovalent cation:hydrogen antiporter activity, ! cGMP metabolic process GO:0046068 10 9 0,000 3,84E-03 0,01112772 ! myotube differentiation GO:0014902 9 9 0,000 3,84E-03 0,01111889 ! folic acid and derivative biosynthetic process GO:0009396 9 9 0,000 3,84E-03 0,01111007 ! N-glycan processing GO:0006491 10 9 0,000 3,84E-03 0,01110127 ! regulation of epidermal growth factor receptor activity GO:0007176 11 9 0,000 3,84E-03 0,01109248 ! actin-myosin filament sliding GO:0033275 11 9 0,000 3,84E-03 0,0110837 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! axon part GO:0033267 12 9 0,000 3,84E-03 0,01107494 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 10 9 0,000 3,84E-03 0,01106619 ! RNA methylation GO:0001510 9 9 0,000 3,84E-03 0,01105746 ! prostaglandin biosynthetic process GO:0001516 9 9 0,000 3,84E-03 0,01104874 GO:0046457|prostanoid biosynthetic process, ! negative regulation of gene-specific transcription GO:0032582 10 9 0,000 3,84E-03 0,01104003 ! artery development GO:0060840 9 9 0,000 3,84E-03 0,01103134 GO:0048844|artery morphogenesis, ! axonemal dynein complex GO:0005858 9 9 0,000 3,84E-03 0,01102266 ! regulation of postsynaptic membrane potential GO:0060078 11 9 0,000 3,84E-03 0,01101399 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 9 9 0,000 3,84E-03 0,01100534 ! auditory receptor cell differentiation GO:0042491 10 9 0,000 3,84E-03 0,0109967 ! positive regulation of heart contraction GO:0045823 11 9 0,000 3,84E-03 0,01098808 ! lipopolysaccharide binding GO:0001530 9 9 0,000 3,84E-03 0,01097947 ! regulated secretory pathway GO:0045055 10 9 0,000 3,84E-03 0,01097087 ! estrogen receptor binding GO:0030331 9 9 0,000 3,84E-03 0,01096228 ! inner mitochondrial membrane organization GO:0007007 10 9 0,000 3,84E-03 0,01095371 ! telomere maintenance via telomerase GO:0007004 20 9 0,000 3,84E-03 0,01094515 GO:0006278|RNA-dependent DNA replication, ! L-phenylalanine metabolic process GO:0006558 9 9 0,000 3,84E-03 0,01093661 GO:0006559|L-phenylalanine catabolic process, ! indolalkylamine metabolic process GO:0006586 9 9 0,000 3,84E-03 0,01092808 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! urea metabolic process GO:0019627 19 9 0,000 3,84E-03 0,01091956 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! smooth endoplasmic reticulum GO:0005790 11 9 0,000 3,84E-03 0,01091106 ! autophagic vacuole GO:0005776 11 9 0,000 3,84E-03 0,01090257 ! Rac GTPase binding GO:0048365 10 9 0,000 3,84E-03 0,01089409 ! response to dietary excess GO:0002021 9 9 0,000 3,84E-03 0,01088562 ! regulation of sodium ion transport GO:0002028 10 9 0,000 3,84E-03 0,01087717 ! positive regulation of calcium ion transport into cytosol GO:0010524 13 9 0,000 3,84E-03 0,01086873 ! lens development in camera-type eye GO:0002088 9 9 0,000 3,84E-03 0,01086031 ! male sex determination GO:0030238 9 9 0,000 3,84E-03 0,0108519 ! positive regulation of vasodilation GO:0045909 19 9 0,000 3,84E-03 0,0108435 ! positive regulation of muscle contraction GO:0045933 11 9 0,000 3,84E-03 0,01083511 ! regulation of smoothened signaling pathway GO:0008589 11 9 0,000 3,84E-03 0,01082674 ! male germ cell nucleus GO:0001673 11 9 0,000 3,84E-03 0,01081838 ! negative regulation of foam cell differentiation GO:0010745 12 9 0,000 3,84E-03 0,01081003 ! copper ion homeostasis GO:0055070 9 9 0,000 3,84E-03 0,01080169 ! protein heterooligomerization GO:0051291 10 9 0,000 3,84E-03 0,01079337 ! spectrin GO:0008091 9 9 0,000 3,84E-03 0,01078506 ! cardiac muscle cell differentiation GO:0055007 12 9 0,000 3,84E-03 0,01077677 ! purine nucleoside triphosphate catabolic process GO:0009146 9 9 0,000 3,84E-03 0,01076848 ! synaptic vesicle exocytosis GO:0016079 10 9 0,000 3,84E-03 0,01076021 ! regulation of B cell differentiation GO:0045577 10 9 0,000 3,84E-03 0,01075196 ! cell differentiation in hindbrain GO:0021533 10 9 0,000 3,84E-03 0,01074371 ! neural tube patterning GO:0021532 10 9 0,000 3,84E-03 0,01073548 ! fucose catabolic process GO:0019317 10 9 0,000 3,84E-03 0,01072726 GO:0042355|L-fucose catabolic process, ! retinal ganglion cell axon guidance GO:0031290 10 9 0,000 3,84E-03 0,01071905 ! regulation of hormone metabolic process GO:0032350 12 9 0,000 3,84E-03 0,01071085 ! sterol catabolic process GO:0016127 10 9 0,000 3,84E-03 0,01070267 GO:0006707|cholesterol catabolic process, ! oligosaccharyl transferase activity GO:0004576 9 9 0,000 3,84E-03 0,0106945 ! clathrin coat of coated pit GO:0030132 11 9 0,000 3,84E-03 0,01068634 ! SNARE complex GO:0031201 11 9 0,000 3,84E-03 0,0106782 ! negative regulation of osteoclast differentiation GO:0045671 10 9 0,000 3,84E-03 0,01067007 ! negative regulation of glucose transport GO:0010829 10 9 0,000 3,84E-03 0,01066195 ! methionine biosynthetic process GO:0009086 11 9 0,000 3,84E-03 0,01065384 ! peptidoglycan binding GO:0042834 9 9 0,000 3,84E-03 0,01064574 ! serine family amino acid biosynthetic process GO:0009070 10 9 0,000 3,84E-03 0,01063766 ! somatic diversification of immunoglobulins during immune response GO:0002208 9 9 0,000 3,84E-03 0,01062959 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! nicotinamide nucleotide biosynthetic process GO:0019359 10 9 0,000 3,84E-03 0,01062153 ! intramolecular oxidoreductase activity, transposing S-S bonds GO:0016864 9 9 0,000 3,84E-03 0,01061348 GO:0003756|protein disulfide isomerase activity, ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor GO:0016884 9 9 0,000 3,84E-03 0,01060545 ! beta-1,3-galactosyltransferase activity GO:0048531 10 9 0,000 3,84E-03 0,01059743 ! detection of bacterium GO:0016045 10 9 0,000 3,84E-03 0,01058942 ! lymphocyte activation during immune response GO:0002285 9 9 0,000 3,84E-03 0,01058142 ! embryonic gut development GO:0048566 10 9 0,000 3,84E-03 0,01057343 ! hydrolase activity, acting on ether bonds GO:0016801 10 9 0,000 3,84E-03 0,01056546 ! desmosome GO:0030057 10 9 0,000 3,84E-03 0,0105575 ! long-chain-fatty-acid-CoA ligase activity GO:0004467 9 9 0,000 3,84E-03 0,01054955 ! T cell receptor signaling pathway GO:0050852 14 9 0,000 3,84E-03 0,01054161 ! positive regulation of calcium-mediated signaling GO:0050850 11 9 0,000 3,84E-03 0,01053368 ! actin filament polymerization GO:0030041 10 9 0,000 3,84E-03 0,01052577 ! negative regulation of B cell activation GO:0050869 10 9 0,000 3,84E-03 0,01051787 ! establishment of cell polarity GO:0030010 10 9 0,000 3,84E-03 0,01050998 ! regulation of synapse organization GO:0050807 10 9 0,000 3,84E-03 0,0105021 ! septin complex GO:0031105 10 9 0,000 3,84E-03 0,01049423 GO:0032156|septin cytoskeleton, ! cholesterol transporter activity GO:0017127 9 9 0,000 3,84E-03 0,01048638 ! anchoring collagen GO:0030934 9 9 0,000 3,84E-03 0,01047853 ! defense response to Gram-negative bacterium GO:0050829 10 9 0,000 3,84E-03 0,0104707 ! regulation of developmental growth GO:0048638 11 9 0,000 3,84E-03 0,01046288 ! negative regulation of smooth muscle cell proliferation GO:0048662 10 9 0,000 3,84E-03 0,01045507 ! GMP binding GO:0019002 11 9 0,000 3,84E-03 0,01044728 GO:0030553|cGMP binding, ! photoreceptor activity GO:0009881 10 9 0,000 3,84E-03 0,01043949 ! virus-host interaction GO:0019048 13 9 0,000 3,84E-03 0,01043172 ! pentose-phosphate shunt GO:0006098 11 9 0,000 3,84E-03 0,01042396 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 9 9 0,000 3,84E-03 0,01041621 ! negative regulation of lipid catabolic process GO:0050995 11 9 0,000 3,84E-03 0,01040847 ! non-recombinational repair GO:0000726 10 9 0,000 3,84E-03 0,01040074 GO:0006303|double-strand break repair via nonhomologous end joining, ! cell volume homeostasis GO:0006884 10 9 0,000 3,84E-03 0,01039302 ! nuclear telomere cap complex GO:0000783 10 9 0,000 3,84E-03 0,01038532 GO:0000782|telomere cap complex, ! activin binding GO:0048185 10 9 0,000 3,84E-03 0,01037763 ! social behavior GO:0035176 10 9 0,000 3,84E-03 0,01036995 ! regulation of positive chemotaxis GO:0050926 11 9 0,000 3,84E-03 0,01036228 GO:0050927|positive regulation of positive chemotaxis, ! perikaryon GO:0043204 11 9 0,000 3,84E-03 0,01035462 ! nitric oxide biosynthetic process GO:0006809 10 9 0,000 3,84E-03 0,01034697 ! mating GO:0007618 11 9 0,000 3,84E-03 0,01033933 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 9 0,000 3,84E-03 0,01033171 ! rhythmic behavior GO:0007622 11 9 0,000 3,84E-03 0,0103241 ! phospholipid efflux GO:0033700 10 9 0,000 3,84E-03 0,01031649 ! cytoplasmic sequestering of transcription factor GO:0042994 9 9 0,000 3,84E-03 0,0103089 ! poly-purine tract binding GO:0070717 9 9 0,000 3,84E-03 0,01030132 ! T cell proliferation GO:0042098 10 9 0,000 3,84E-03 0,01029375 ! retinol dehydrogenase activity GO:0004745 9 9 0,000 3,84E-03 0,0102862 ! negative regulation of cell-matrix adhesion GO:0001953 10 9 0,000 3,84E-03 0,01027865 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 9 9 0,000 3,84E-03 0,01027111 ! interleukin-1 binding GO:0019966 10 9 0,000 3,84E-03 0,01026359 ! glucosyltransferase activity GO:0046527 9 9 0,000 3,84E-03 0,01025607 ! platelet-derived growth factor receptor signaling pathway GO:0048008 14 9 0,000 3,84E-03 0,01024857 ! cyclic nucleotide-dependent protein kinase activity GO:0004690 11 9 0,000 3,84E-03 0,01024108 ! ovulation GO:0030728 9 9 0,000 3,84E-03 0,0102336 ! acid phosphatase activity GO:0003993 18 9 0,000 3,84E-03 0,01022613 ! embryonic cranial skeleton morphogenesis GO:0048701 10 9 0,000 3,84E-03 0,01021867 ! ER overload response GO:0006983 11 9 0,000 3,84E-03 0,01021122 ! B cell proliferation GO:0042100 10 9 0,000 3,84E-03 0,01020379 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 11 9 0,000 3,84E-03 0,01019636 ! calcium-transporting ATPase activity GO:0005388 11 9 0,000 3,84E-03 0,01018894 ! mannose metabolic process GO:0006013 13 9 0,000 3,84E-03 0,01018154 ! lipid digestion GO:0044241 11 9 0,000 3,84E-03 0,01017414 ! tumor necrosis factor binding GO:0043120 9 9 0,000 3,84E-03 0,01016676 ! tRNA methyltransferase activity GO:0008175 9 9 0,000 3,84E-03 0,01015939 ! regulation of bone resorption GO:0045124 10 9 0,000 3,84E-03 0,01015203 ! brain morphogenesis GO:0048854 9 9 0,000 3,84E-03 0,01014468 ! positive regulation of alpha-beta T cell differentiation GO:0046638 10 9 0,000 3,84E-03 0,01013734 ! 1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 10 9 0,000 3,84E-03 0,01013001 ! synaptic vesicle membrane GO:0030672 9 9 0,000 3,84E-03 0,01012269 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 9 0,000 3,84E-03 0,01011538 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9 9 0,000 3,84E-03 0,01010808 ! kinesin binding GO:0019894 9 9 0,000 3,84E-03 0,01010079 ! multicellular organismal aging GO:0010259 18 9 0,000 3,84E-03 0,01009351 ! Ran GTPase binding GO:0008536 11 9 0,000 3,84E-03 0,01008625 ! ribosomal small subunit biogenesis GO:0042274 9 9 0,000 3,84E-03 0,01007899 ! protein import into peroxisome matrix GO:0016558 9 9 0,000 3,84E-03 0,01007175 ! mRNA polyadenylation GO:0006378 10 9 0,000 3,84E-03 0,01006451 ! neuropeptide Y receptor activity GO:0004983 10 9 0,000 3,84E-03 0,01005728 ! mannosyl-oligosaccharide mannosidase activity GO:0015924 14 9 0,000 3,84E-03 0,01005007 ! prostaglandin receptor activity GO:0004955 11 9 0,000 3,84E-03 0,01004287 ! caspase inhibitor activity GO:0043027 9 9 0,000 3,84E-03 0,01003567 ! adrenoceptor activity GO:0004935 12 9 0,000 3,84E-03 0,01002849 ! regulation of isotype switching GO:0045191 9 9 0,000 3,84E-03 0,01002131 ! positive regulation of leukocyte migration GO:0002687 10 9 0,000 3,84E-03 0,01001415 ! transmembrane receptor protein tyrosine kinase signaling protein activity GO:0005066 10 9 0,000 3,84E-03 0,010007 ! positive regulation of ATPase activity GO:0032781 11 9 0,000 3,84E-03 1E-02 ! nonprotein amino acid metabolic process GO:0019794 19 9 0,000 3,84E-03 9,993E-03 ! ionotropic glutamate receptor complex GO:0008328 14 9 0,000 3,84E-03 9,986E-03 ! Notch binding GO:0005112 10 9 0,000 3,84E-03 9,978E-03 ! ATPase regulator activity GO:0060590 10 9 0,000 3,84E-03 9,971E-03 ! gamma-tubulin complex GO:0000930 19 9 0,000 3,84E-03 9,964E-03 ! pyrimidine base metabolic process GO:0006206 10 9 0,000 3,84E-03 9,957E-03 ! establishment or maintenance of apical/basal cell polarity GO:0035088 10 9 0,000 3,84E-03 9,95E-03 ! tubulin-tyrosine ligase activity GO:0004835 10 9 0,000 3,84E-03 9,943E-03 ! alcohol dehydrogenase (NAD) activity GO:0004022 10 9 0,000 3,84E-03 9,936E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 12 10 0,000 4,266E-03 0,01103014 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 12 10 0,000 4,266E-03 0,01102233 ! oligosaccharide biosynthetic process GO:0009312 10 10 0,000 4,266E-03 0,01101453 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 11 10 0,000 4,266E-03 0,01100674 ! sleep GO:0030431 11 10 0,000 4,266E-03 0,01099896 ! positive regulation of lipid biosynthetic process GO:0046889 10 10 0,000 4,266E-03 0,01099119 ! lipid particle GO:0005811 10 10 0,000 4,266E-03 0,01098344 ! filopodium assembly GO:0046847 14 10 0,000 4,266E-03 0,01097569 ! UTP metabolic process GO:0046051 12 10 0,000 4,266E-03 0,01096796 GO:0004550|nucleoside diphosphate kinase activity, GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! Wnt receptor signaling pathway through beta-catenin GO:0060070 13 10 0,000 4,266E-03 0,01096023 ! guanylate kinase activity GO:0004385 14 10 0,000 4,266E-03 0,01095252 ! integral to mitochondrial membrane GO:0032592 10 10 0,000 4,266E-03 0,01094482 ! COPI coating of Golgi vesicle GO:0048205 11 10 0,000 4,266E-03 0,01093713 GO:0048200|Golgi transport vesicle coating, ! platelet alpha granule membrane GO:0031092 11 10 0,000 4,266E-03 0,01092945 ! macromolecule transmembrane transporter activity GO:0022884 11 10 0,000 4,266E-03 0,01092178 GO:0015450|P-P-bond-hydrolysis-driven protein transmembrane transporter activity, ! estradiol 17-beta-dehydrogenase activity GO:0004303 11 10 0,000 4,266E-03 0,01091412 ! thyroid hormone receptor coactivator activity GO:0030375 11 10 0,000 4,266E-03 0,01090647 GO:0010861|thyroid hormone receptor activator activity, ! regulation of receptor activity GO:0010469 12 10 0,000 4,266E-03 0,01089883 ! lung alveolus development GO:0048286 11 10 0,000 4,266E-03 0,0108912 ! regulation of chemokine biosynthetic process GO:0045073 11 10 0,000 4,266E-03 0,01088359 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 4,266E-03 0,01087598 ! negative regulation of striated muscle development GO:0045843 11 10 0,000 4,266E-03 0,01086839 ! oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GO:0050664 10 10 0,000 4,266E-03 0,0108608 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 11 10 0,000 4,266E-03 0,01085323 ! regulation of mRNA processing GO:0050684 12 10 0,000 4,266E-03 0,01084567 ! positive regulation of survival gene product expression GO:0045885 12 10 0,000 4,266E-03 0,01083811 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 11 10 0,000 4,266E-03 0,01083057 ! transforming growth factor beta binding GO:0050431 11 10 0,000 4,266E-03 0,01082304 ! histidine metabolic process GO:0006547 10 10 0,000 4,266E-03 0,01081552 GO:0009075|histidine family amino acid metabolic process, ! glucan biosynthetic process GO:0009250 10 10 0,000 4,266E-03 0,01080801 GO:0005978|glycogen biosynthetic process, ! endosome organization GO:0007032 13 10 0,000 4,266E-03 0,01080051 ! death receptor activity GO:0005035 11 10 0,000 4,266E-03 0,01079302 ! mitochondrial inner membrane presequence translocase complex GO:0005744 11 10 0,000 4,266E-03 0,01078554 ! entry into host cell GO:0030260 11 10 0,000 4,266E-03 0,01077807 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! protein kinase A binding GO:0051018 10 10 0,000 4,266E-03 0,01077061 ! filamentous actin GO:0031941 11 10 0,000 4,266E-03 0,01076316 ! behavioral fear response GO:0001662 12 10 0,000 4,266E-03 0,01075572 GO:0002209|behavioral defense response, ! bone mineralization GO:0030282 12 10 0,000 4,266E-03 0,0107483 ! negative regulation of ossification GO:0030279 12 10 0,000 4,266E-03 0,01074088 ! phosphatidylcholine biosynthetic process GO:0006656 11 10 0,000 4,266E-03 0,01073347 ! macrophage differentiation GO:0030225 11 10 0,000 4,266E-03 0,01072607 ! positive regulation of phagocytosis GO:0050766 11 10 0,000 4,266E-03 0,01071869 ! recycling endosome membrane GO:0055038 11 10 0,000 4,266E-03 0,01071131 ! regulation of fat cell differentiation GO:0045598 11 10 0,000 4,266E-03 0,01070394 ! snRNA metabolic process GO:0016073 10 10 0,000 4,266E-03 0,01069659 GO:0016180|snRNA processing, ! glycosphingolipid biosynthetic process GO:0006688 11 10 0,000 4,266E-03 0,01068924 ! regulation of mitochondrial membrane potential GO:0051881 11 10 0,000 4,266E-03 0,0106819 ! purine ribonucleotide catabolic process GO:0009154 10 10 0,000 4,266E-03 0,01067458 ! immunoglobulin production during immune response GO:0002381 10 10 0,000 4,266E-03 0,01066726 ! nitric oxide metabolic process GO:0046209 20 10 0,000 4,266E-03 0,01065995 ! induction of an organ GO:0001759 12 10 0,000 4,266E-03 0,01065266 ! response to estradiol stimulus GO:0032355 11 10 0,000 4,266E-03 0,01064537 ! synaptic vesicle endocytosis GO:0048488 12 10 0,000 4,266E-03 0,01063809 ! negative regulation of MAPKKK cascade GO:0043409 12 10 0,000 4,266E-03 0,01063083 ! positive regulation of interleukin-1 beta secretion GO:0050718 11 10 0,000 4,266E-03 0,01062357 ! MHC class II receptor activity GO:0032395 14 10 0,000 4,266E-03 0,01061632 ! peptidyl-lysine modification GO:0018205 11 10 0,000 4,266E-03 0,01060909 ! ribonuclease P activity GO:0004526 10 10 0,000 4,266E-03 0,01060186 ! COPI vesicle coat GO:0030126 12 10 0,000 4,266E-03 0,01059464 GO:0030663|COPI coated vesicle membrane, ! telomere maintenance via telomere lengthening GO:0010833 21 10 0,000 4,266E-03 0,01058744 ! vitamin transporter activity GO:0051183 12 10 0,000 4,266E-03 0,01058024 ! snRNA binding GO:0017069 11 10 0,000 4,266E-03 0,01057305 ! negative regulation of osteoblast differentiation GO:0045668 12 10 0,000 4,266E-03 0,01056587 ! heparan sulfate sulfotransferase activity GO:0034483 10 10 0,000 4,266E-03 0,01055871 ! fatty-acid ligase activity GO:0015645 10 10 0,000 4,266E-03 0,01055155 ! intramolecular transferase activity, phosphotransferases GO:0016868 11 10 0,000 4,266E-03 0,0105444 ! quaternary ammonium group transport GO:0015697 10 10 0,000 4,266E-03 0,01053726 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups GO:0016862 10 10 0,000 4,266E-03 0,01053013 ! metalloenzyme inhibitor activity GO:0048551 11 10 0,000 4,266E-03 0,01052301 GO:0008191|metalloendopeptidase inhibitor activity, GO:0010576|metalloenzyme regulator activity, ! anterior/posterior axis specification GO:0009948 14 10 0,000 4,266E-03 0,0105159 ! regulation of RNA splicing GO:0043484 13 10 0,000 4,266E-03 0,0105088 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0016813 10 10 0,000 4,266E-03 0,01050171 ! trophectodermal cell differentiation GO:0001829 11 10 0,000 4,266E-03 0,01049463 ! positive regulation of neuron apoptosis GO:0043525 11 10 0,000 4,266E-03 0,01048756 ! extracellular matrix binding GO:0050840 11 10 0,000 4,266E-03 0,01048049 ! regulation of synapse structure and activity GO:0050803 11 10 0,000 4,266E-03 0,01047344 ! autophagic vacuole formation GO:0000045 11 10 0,000 4,266E-03 0,0104664 ! clathrin-coated endocytic vesicle GO:0045334 10 10 0,000 4,266E-03 0,01045936 ! negative regulation of cell projection organization GO:0031345 14 10 0,000 4,266E-03 0,01045234 ! negative regulation of cellular catabolic process GO:0031330 11 10 0,000 4,266E-03 0,01044532 ! rough endoplasmic reticulum membrane GO:0030867 10 10 0,000 4,266E-03 0,01043832 ! thyroid gland development GO:0030878 12 10 0,000 4,266E-03 0,01043132 ! DNA bending activity GO:0008301 11 10 0,000 4,266E-03 0,01042433 ! neutral lipid biosynthetic process GO:0046460 10 10 0,000 4,266E-03 0,01041736 GO:0046463|acylglycerol biosynthetic process, ! embryonic hindlimb morphogenesis GO:0035116 11 10 0,000 4,266E-03 0,01041039 ! embryonic forelimb morphogenesis GO:0035115 12 10 0,000 4,266E-03 0,01040343 ! regulation of glucan biosynthetic process GO:0010962 10 10 0,000 4,266E-03 0,01039648 GO:0005979|regulation of glycogen biosynthetic process, GO:0032885|regulation of polysaccharide biosynthetic process, ! secondary active sulfate transmembrane transporter activity GO:0008271 11 10 0,000 4,266E-03 0,01038954 ! regulation of glycolysis GO:0006110 11 10 0,000 4,266E-03 0,01038261 ! nucleotidase activity GO:0008252 10 10 0,000 4,266E-03 0,01037569 ! phosphatidylinositol phosphate kinase activity GO:0016307 11 10 0,000 4,266E-03 0,01036878 ! dipeptidyl-peptidase activity GO:0008239 12 10 0,000 4,266E-03 0,01036187 ! androgen metabolic process GO:0008209 11 10 0,000 4,266E-03 0,01035498 ! lateral plasma membrane GO:0016328 13 10 0,000 4,266E-03 0,01034809 ! MAP kinase kinase activity GO:0004708 12 10 0,000 4,266E-03 0,01034122 ! cation:amino acid symporter activity GO:0005416 12 10 0,000 4,266E-03 0,01033435 ! startle response GO:0001964 13 10 0,000 4,266E-03 0,01032749 ! amyloid precursor protein metabolic process GO:0042982 12 10 0,000 4,266E-03 0,01032064 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 12 10 0,000 4,266E-03 0,01031381 ! positive regulation of endothelial cell proliferation GO:0001938 13 10 0,000 4,266E-03 0,01030697 ! 3'-5'-exoribonuclease activity GO:0000175 10 10 0,000 4,266E-03 0,01030015 ! spinal cord patterning GO:0021511 12 10 0,000 4,266E-03 0,01029334 ! peptide or protein amino-terminal blocking GO:0018409 11 10 0,000 4,266E-03 0,01028654 ! MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017 10 10 0,000 4,266E-03 0,01027974 GO:0033549|MAP kinase phosphatase activity, ! response to X-ray GO:0010165 11 10 0,000 4,266E-03 0,01027296 ! embryonic eye morphogenesis GO:0048048 14 10 0,000 4,266E-03 0,01026618 ! sodium:potassium-exchanging ATPase activity GO:0005391 12 10 0,000 4,266E-03 0,01025941 ! zinc ion transmembrane transporter activity GO:0005385 13 10 0,000 4,266E-03 0,01025266 ! positive regulation of glycogen metabolic process GO:0070875 11 10 0,000 4,266E-03 0,01024591 ! glucose transmembrane transporter activity GO:0005355 10 10 0,000 4,266E-03 0,01023917 ! regulation of intracellular pH GO:0051453 10 10 0,000 4,266E-03 0,01023243 ! retrograde transport, endosome to Golgi GO:0042147 12 10 0,000 4,266E-03 0,01022571 ! regulation of multicellular organismal metabolic process GO:0044246 11 10 0,000 4,266E-03 0,010219 ! adult heart development GO:0007512 14 10 0,000 4,266E-03 0,01021229 ! neuromuscular junction development GO:0007528 12 10 0,000 4,266E-03 0,01020559 ! carbohydrate phosphatase activity GO:0019203 11 10 0,000 4,266E-03 0,01019891 ! O-methyltransferase activity GO:0008171 10 10 0,000 4,266E-03 0,01019223 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 10 10 0,000 4,266E-03 0,01018556 ! signalosome GO:0008180 10 10 0,000 4,266E-03 0,0101789 ! lysophospholipase activity GO:0004622 19 10 0,000 4,266E-03 0,01017224 ! prefoldin complex GO:0016272 10 10 0,000 4,266E-03 0,0101656 ! alpha-beta T cell differentiation GO:0046632 12 10 0,000 4,266E-03 0,01015896 ! negative regulation of insulin receptor signaling pathway GO:0046627 12 10 0,000 4,266E-03 0,01015234 ! positive regulation of T cell mediated immunity GO:0002711 10 10 0,000 4,266E-03 0,01014572 ! nucleoside bisphosphate metabolic process GO:0033865 10 10 0,000 4,266E-03 0,01013911 ! endocytic vesicle membrane GO:0030666 10 10 0,000 4,266E-03 0,01013251 ! gland morphogenesis GO:0022612 11 10 0,000 4,266E-03 0,01012592 ! icosanoid receptor activity GO:0004953 13 10 0,000 4,266E-03 0,01011933 GO:0004954|prostanoid receptor activity, ! regulation of macrophage activation GO:0043030 11 10 0,000 4,266E-03 0,01011276 ! peptide transporter activity GO:0015197 10 10 0,000 4,266E-03 0,01010619 ! proton-transporting ATP synthase complex, coupling factor F(o) GO:0045263 10 10 0,000 4,266E-03 0,01009963 ! regulation of leukocyte migration GO:0002685 11 10 0,000 4,266E-03 0,01009308 ! muscle maintenance GO:0046716 10 10 0,000 4,266E-03 0,01008654 ! acid secretion GO:0046717 12 10 0,000 4,266E-03 0,01008001 ! retinoid-X receptor activity GO:0004886 11 10 0,000 4,266E-03 0,01007348 ! catecholamine biosynthetic process GO:0042423 11 10 0,000 4,266E-03 0,01006697 ! thyroid hormone metabolic process GO:0042403 11 10 0,000 4,266E-03 0,01006046 ! GTPase inhibitor activity GO:0005095 21 10 0,000 4,266E-03 0,01005396 ! somatic recombination of immunoglobulin gene segments GO:0016447 10 10 0,000 4,266E-03 0,01004747 ! pattern recognition receptor activity GO:0008329 10 10 0,000 4,266E-03 0,01004099 ! quinone cofactor metabolic process GO:0042375 11 10 0,000 4,266E-03 0,01003451 ! regulation of organic acid transport GO:0032890 12 10 0,000 4,266E-03 0,01002805 ! platelet-derived growth factor receptor binding GO:0005161 14 10 0,000 4,266E-03 0,01002159 ! C-acyltransferase activity GO:0016408 12 10 0,000 4,266E-03 0,01001514 ! cAMP-dependent protein kinase complex GO:0005952 12 10 0,000 4,266E-03 0,0100087 ! water channel activity GO:0015250 15 10 0,000 4,266E-03 0,01000227 ! phospholipase inhibitor activity GO:0004859 10 10 0,000 4,266E-03 9,996E-03 ! regulation of embryonic development GO:0045995 12 10 0,000 4,266E-03 9,989E-03 ! cyclin-dependent protein kinase inhibitor activity GO:0004861 10 10 0,000 4,266E-03 9,983E-03 ! acrosome reaction GO:0007340 12 10 0,000 4,266E-03 9,977E-03 ! mitochondrion localization GO:0051646 10 10 0,000 4,266E-03 9,97E-03 ! cilium part GO:0044441 10 10 0,000 4,266E-03 9,964E-03 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 12 11 0,000 4,692E-03 0,01095117 ! 'de novo' posttranslational protein folding GO:0051084 11 11 0,000 4,692E-03 0,01094417 ! negative regulation of blood pressure GO:0045776 13 11 0,000 4,692E-03 0,01093718 ! centriole GO:0005814 11 11 0,000 4,692E-03 0,01093019 ! cadmium ion binding GO:0046870 15 11 0,000 4,692E-03 0,01092322 ! hemoglobin complex GO:0005833 13 11 0,000 4,692E-03 0,01091625 ! CTP metabolic process GO:0046036 13 11 0,000 4,692E-03 0,0109093 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0009148|pyrimidine nucleoside triphosphate biosynthetic process, ! regulation of neurotransmitter secretion GO:0046928 12 11 0,000 4,692E-03 0,01090235 ! response to pain GO:0048265 12 11 0,000 4,692E-03 0,01089541 ! regulation of viral genome replication GO:0045069 13 11 0,000 4,692E-03 0,01088848 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 11 11 0,000 4,692E-03 0,01088155 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 12 11 0,000 4,692E-03 0,01087464 ! nucleotide-sugar metabolic process GO:0009225 13 11 0,000 4,692E-03 0,01086774 ! regulation of catecholamine secretion GO:0050433 12 11 0,000 4,692E-03 0,01086084 ! low-density lipoprotein receptor activity GO:0005041 11 11 0,000 4,692E-03 0,01085395 ! peptide antigen binding GO:0042605 14 11 0,000 4,692E-03 0,01084708 ! polyamine metabolic process GO:0006595 11 11 0,000 4,692E-03 0,01084021 ! lysosphingolipid and lysophosphatidic acid receptor activity GO:0001619 13 11 0,000 4,692E-03 0,01083334 GO:0045125|bioactive lipid receptor activity, ! nucleobase biosynthetic process GO:0046112 13 11 0,000 4,692E-03 0,01082649 ! regulation of calcium ion transport into cytosol GO:0010522 15 11 0,000 4,692E-03 0,01081965 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 12 11 0,000 4,692E-03 0,01081281 GO:0002717|positive regulation of natural killer cell mediated immunity, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 12 11 0,000 4,692E-03 0,01080599 ! protein homotetramerization GO:0051289 13 11 0,000 4,692E-03 0,01079917 ! regulation of gliogenesis GO:0014013 13 11 0,000 4,692E-03 0,01079236 GO:0045685|regulation of glial cell differentiation, ! oligodendrocyte development GO:0014003 11 11 0,000 4,692E-03 0,01078556 ! cytoskeletal adaptor activity GO:0008093 17 11 0,000 4,692E-03 0,01077877 ! regulation of circadian rhythm GO:0042752 11 11 0,000 4,692E-03 0,01077199 ! low-density lipoprotein receptor binding GO:0050750 11 11 0,000 4,692E-03 0,01076521 ! response to dsRNA GO:0043331 21 11 0,000 4,692E-03 0,01075844 ! response to amine stimulus GO:0014075 15 11 0,000 4,692E-03 0,01075169 GO:0010243|response to organic nitrogen, ! embryonic axis specification GO:0000578 14 11 0,000 4,692E-03 0,01074494 ! sphingomyelin metabolic process GO:0006684 13 11 0,000 4,692E-03 0,0107382 ! cell wall macromolecule catabolic process GO:0016998 14 11 0,000 4,692E-03 0,01073146 ! spinal cord motor neuron differentiation GO:0021522 12 11 0,000 4,692E-03 0,01072474 ! retinal binding GO:0016918 11 11 0,000 4,692E-03 0,01071802 ! leukocyte activation during immune response GO:0002366 11 11 0,000 4,692E-03 0,01071132 GO:0002263|cell activation during immune response, ! regulation of sterol transport GO:0032371 12 11 0,000 4,692E-03 0,01070462 GO:0032374|regulation of cholesterol transport, ! beta-tubulin binding GO:0048487 14 11 0,000 4,692E-03 0,01069793 ! autonomic nervous system development GO:0048483 12 11 0,000 4,692E-03 0,01069125 ! negative regulation of lipid transport GO:0032369 12 11 0,000 4,692E-03 0,01068457 ! photoreceptor outer segment GO:0001750 12 11 0,000 4,692E-03 0,01067791 ! positive regulation of interleukin-1 secretion GO:0050716 12 11 0,000 4,692E-03 0,01067125 ! peptidyl-threonine modification GO:0018210 15 11 0,000 4,692E-03 0,0106646 ! clathrin coat of trans-Golgi network vesicle GO:0030130 15 11 0,000 4,692E-03 0,01065796 ! regulation of interleukin-1 beta secretion GO:0050706 12 11 0,000 4,692E-03 0,01065133 ! regulation of epidermis development GO:0045682 14 11 0,000 4,692E-03 0,0106447 ! positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 11 11 0,000 4,692E-03 0,01063809 ! midbrain development GO:0030901 12 11 0,000 4,692E-03 0,01063148 ! musculoskeletal movement GO:0050881 12 11 0,000 4,692E-03 0,01062488 GO:0050879|multicellular organismal movement, ! histone deacetylase binding GO:0042826 11 11 0,000 4,692E-03 0,01061829 ! regulation of RNA stability GO:0043487 13 11 0,000 4,692E-03 0,01061171 GO:0043488|regulation of mRNA stability, ! intramolecular oxidoreductase activity, transposing C=C bonds GO:0016863 11 11 0,000 4,692E-03 0,01060513 ! cell killing GO:0001906 13 11 0,000 4,692E-03 0,01059857 ! regulation of cellular carbohydrate catabolic process GO:0043471 13 11 0,000 4,692E-03 0,01059201 GO:0043470|regulation of carbohydrate catabolic process, ! oocyte development GO:0048599 12 11 0,000 4,692E-03 0,01058546 ! carbon-sulfur lyase activity GO:0016846 11 11 0,000 4,692E-03 0,01057892 ! cerebellar cortex morphogenesis GO:0021696 13 11 0,000 4,692E-03 0,01057238 ! regulation of blood vessel endothelial cell migration GO:0043535 13 11 0,000 4,692E-03 0,01056585 ! folic acid binding GO:0005542 12 11 0,000 4,692E-03 0,01055934 ! mRNA 3'-end processing GO:0031124 12 11 0,000 4,692E-03 0,01055283 ! regulation of calcium-mediated signaling GO:0050848 13 11 0,000 4,692E-03 0,01054632 ! positive regulation of protein polymerization GO:0032273 11 11 0,000 4,692E-03 0,01053983 ! microspike assembly GO:0030035 15 11 0,000 4,692E-03 0,01053334 ! lamellipodium assembly GO:0030032 22 11 0,000 4,692E-03 0,01052687 ! fibrillar collagen GO:0005583 12 11 0,000 4,692E-03 0,0105204 ! inner ear receptor cell differentiation GO:0060113 12 11 0,000 4,692E-03 0,01051393 ! cytoplasmic sequestering of protein GO:0051220 12 11 0,000 4,692E-03 0,01050748 ! negative regulation of muscle development GO:0048635 13 11 0,000 4,692E-03 0,01050103 ! very-long-chain fatty acid metabolic process GO:0000038 12 11 0,000 4,692E-03 0,0104946 ! synaptonemal complex GO:0000795 11 11 0,000 4,692E-03 0,01048816 ! reproductive cellular process GO:0048610 13 11 0,000 4,692E-03 0,01048174 ! cortical actin cytoskeleton organization GO:0030866 12 11 0,000 4,692E-03 0,01047533 ! positive regulation of B cell proliferation GO:0030890 15 11 0,000 4,692E-03 0,01046892 ! Golgi vesicle budding GO:0048194 12 11 0,000 4,692E-03 0,01046252 ! response to cAMP GO:0051591 11 11 0,000 4,692E-03 0,01045613 ! detection of mechanical stimulus GO:0050982 13 11 0,000 4,692E-03 0,01044975 ! 1-phosphatidylinositol-3-kinase activity GO:0016303 13 11 0,000 4,692E-03 0,01044337 ! regulation of cell projection assembly GO:0060491 11 11 0,000 4,692E-03 0,010437 ! negative regulation of transcription factor import into nucleus GO:0042992 11 11 0,000 4,692E-03 0,01043064 ! positive regulation of transcription factor import into nucleus GO:0042993 13 11 0,000 4,692E-03 0,01042429 ! macromolecular complex remodeling GO:0034367 11 11 0,000 4,692E-03 0,01041795 GO:0034368|protein-lipid complex remodeling, GO:0034369|plasma lipoprotein particle remodeling, ! protein serine/threonine/tyrosine kinase activity GO:0004712 13 11 0,000 4,692E-03 0,01041161 ! glycerol ether biosynthetic process GO:0046504 11 11 0,000 4,692E-03 0,01040528 ! drug transport GO:0015893 12 11 0,000 4,692E-03 0,01039896 ! FMN binding GO:0010181 12 11 0,000 4,692E-03 0,01039264 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 11 0,000 4,692E-03 0,01038634 ! water transporter activity GO:0005372 17 11 0,000 4,692E-03 0,01038004 ! regulation of glycogen metabolic process GO:0070873 12 11 0,000 4,692E-03 0,01037375 GO:0032881|regulation of polysaccharide metabolic process, ! substrate-bound cell migration GO:0006929 13 11 0,000 4,692E-03 0,01036747 ! multicellular organism growth GO:0035264 12 11 0,000 4,692E-03 0,01036119 ! integrator complex GO:0032039 11 11 0,000 4,692E-03 0,01035492 ! L-glutamate transmembrane transporter activity GO:0005313 13 11 0,000 4,692E-03 0,01034866 GO:0015172|acidic amino acid transmembrane transporter activity, ! DNA integration GO:0015074 11 11 0,000 4,692E-03 0,01034241 ! brush border membrane GO:0031526 12 11 0,000 4,692E-03 0,01033616 ! actin cytoskeleton reorganization GO:0031532 14 11 0,000 4,692E-03 0,01032992 ! macroautophagy GO:0016236 12 11 0,000 4,692E-03 0,01032369 ! protein disulfide oxidoreductase activity GO:0015035 11 11 0,000 4,692E-03 0,01031747 ! neuromuscular junction GO:0031594 12 11 0,000 4,692E-03 0,01031126 ! positive regulation of peptide secretion GO:0002793 13 11 0,000 4,692E-03 0,01030505 ! positive regulation of alpha-beta T cell activation GO:0046635 12 11 0,000 4,692E-03 0,01029885 ! organic anion transmembrane transporter activity GO:0008514 11 11 0,000 4,692E-03 0,01029265 ! response to antibiotic GO:0046677 13 11 0,000 4,692E-03 0,01028647 ! protein-hormone receptor activity GO:0016500 12 11 0,000 4,692E-03 0,01028029 ! bile acid transmembrane transporter activity GO:0015125 13 11 0,000 4,692E-03 0,01027412 ! proteasome accessory complex GO:0022624 11 11 0,000 4,692E-03 0,01026796 ! neuroblast proliferation GO:0007405 13 11 0,000 4,692E-03 0,0102618 ! non-G-protein coupled 7TM receptor activity GO:0004926 14 11 0,000 4,692E-03 0,01025565 ! negative regulation of neurological system process GO:0031645 13 11 0,000 4,692E-03 0,01024951 ! nitric oxide mediated signal transduction GO:0007263 12 11 0,000 4,692E-03 0,01024338 ! protein kinase C binding GO:0005080 11 11 0,000 4,692E-03 0,01023725 ! transforming growth factor beta receptor, cytoplasmic mediator activity GO:0005072 12 11 0,000 4,692E-03 0,01023113 ! male genitalia development GO:0030539 15 11 0,000 4,692E-03 0,01022502 ! receptor inhibitor activity GO:0030547 12 11 0,000 4,692E-03 0,01021892 GO:0048019|receptor antagonist activity, ! estrogen receptor signaling pathway GO:0030520 12 11 0,000 4,692E-03 0,01021282 ! L-fucose metabolic process GO:0042354 13 11 0,000 4,692E-03 0,01020673 ! palmitoyltransferase activity GO:0016409 11 11 0,000 4,692E-03 0,01020065 ! arylsulfatase activity GO:0004065 12 11 0,000 4,692E-03 0,01019457 ! sterol transporter activity GO:0015248 11 11 0,000 4,692E-03 0,0101885 ! response to nicotine GO:0035094 13 11 0,000 4,692E-03 0,01018244 ! adenylate cyclase activity GO:0004016 11 11 0,000 4,692E-03 0,01017639 ! rRNA transcription GO:0009303 12 12 0,000 5,118E-03 0,01109284 ! ER-associated protein catabolic process GO:0030433 14 12 0,000 5,118E-03 0,01108626 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of blood pressure GO:0045777 15 12 0,000 5,118E-03 0,01107968 ! superoxide anion generation GO:0042554 12 12 0,000 5,118E-03 0,01107311 ! pteridine and derivative biosynthetic process GO:0042559 22 12 0,000 5,118E-03 0,01106654 ! regulation of S phase GO:0033261 16 12 0,000 5,118E-03 0,01105999 ! regulation of chemokine production GO:0032642 13 12 0,000 5,118E-03 0,01105344 ! male meiosis GO:0007140 12 12 0,000 5,118E-03 0,0110469 ! signal complex assembly GO:0007172 15 12 0,000 5,118E-03 0,01104036 ! GTP metabolic process GO:0046039 14 12 0,000 5,118E-03 0,01103384 ! retina morphogenesis in camera-type eye GO:0060042 16 12 0,000 5,118E-03 0,01102732 ! hair follicle morphogenesis GO:0031069 14 12 0,000 5,118E-03 0,01102081 ! voltage-gated sodium channel complex GO:0001518 15 12 0,000 5,118E-03 0,01101431 GO:0034706|sodium channel complex, ! RNA polyadenylation GO:0043631 13 12 0,000 5,118E-03 0,01100782 ! cartilage condensation GO:0001502 14 12 0,000 5,118E-03 0,01100133 ! polysome GO:0005844 14 12 0,000 5,118E-03 0,01099485 ! hippocampus development GO:0021766 13 12 0,000 5,118E-03 0,01098838 ! lipoprotein receptor binding GO:0070325 13 12 0,000 5,118E-03 0,01098192 ! beta-amyloid binding GO:0001540 12 12 0,000 5,118E-03 0,01097546 ! negative regulation of endocytosis GO:0045806 15 12 0,000 5,118E-03 0,01096901 ! regulation of interferon-gamma biosynthetic process GO:0045072 15 12 0,000 5,118E-03 0,01096257 ! regulation of exit from mitosis GO:0007096 31 12 0,000 5,118E-03 0,01095614 ! chylomicron GO:0042627 13 12 0,000 5,118E-03 0,01094971 ! T cell selection GO:0045058 22 12 0,000 5,118E-03 0,01094329 ! negative regulation of proteolysis GO:0045861 12 12 0,000 5,118E-03 0,01093688 ! glycolipid biosynthetic process GO:0009247 13 12 0,000 5,118E-03 0,01093048 ! WW domain binding GO:0050699 12 12 0,000 5,118E-03 0,01092408 ! methionine metabolic process GO:0006555 14 12 0,000 5,118E-03 0,01091769 ! nuclear heterochromatin GO:0005720 12 12 0,000 5,118E-03 0,01091131 ! glycine metabolic process GO:0006544 14 12 0,000 5,118E-03 0,01090494 ! plasma membrane organization GO:0007009 12 12 0,000 5,118E-03 0,01089857 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 5,118E-03 0,01089222 ! ribonucleotide catabolic process GO:0009261 12 12 0,000 5,118E-03 0,01088586 ! Golgi organization GO:0007030 15 12 0,000 5,118E-03 0,01087952 ! hydrogen ion transporting ATP synthase activity, rotational mechanism GO:0046933 12 12 0,000 5,118E-03 0,01087318 ! mitotic spindle organization GO:0007052 13 12 0,000 5,118E-03 0,01086685 ! integral to peroxisomal membrane GO:0005779 12 12 0,000 5,118E-03 0,01086053 ! integral to membrane of membrane fraction GO:0000299 13 12 0,000 5,118E-03 0,01085422 ! regulation of the force of heart contraction GO:0002026 13 12 0,000 5,118E-03 0,01084791 ! temperature homeostasis GO:0001659 13 12 0,000 5,118E-03 0,01084161 ! negative regulation of mitotic cell cycle GO:0045930 15 12 0,000 5,118E-03 0,01083532 ! acyl-CoA metabolic process GO:0006637 12 12 0,000 5,118E-03 0,01082904 ! lipoprotein receptor activity GO:0030228 12 12 0,000 5,118E-03 0,01082276 ! cotranslational protein targeting to membrane GO:0006613 14 12 0,000 5,118E-03 0,01081649 ! axon cargo transport GO:0008088 13 12 0,000 5,118E-03 0,01081022 ! regulation of phagocytosis GO:0050764 14 12 0,000 5,118E-03 0,01080397 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 14 12 0,000 5,118E-03 0,01079772 ! nucleoside triphosphate catabolic process GO:0009143 12 12 0,000 5,118E-03 0,01079148 ! transcription elongation factor complex GO:0008023 12 12 0,000 5,118E-03 0,01078524 ! basal lamina GO:0005605 12 12 0,000 5,118E-03 0,01077902 ! regulation of interleukin-1 secretion GO:0050704 13 12 0,000 5,118E-03 0,0107728 ! pancreatic ribonuclease activity GO:0004522 12 12 0,000 5,118E-03 0,01076658 ! tRNA-specific ribonuclease activity GO:0004549 12 12 0,000 5,118E-03 0,01076038 ! biomineral formation GO:0031214 14 12 0,000 5,118E-03 0,01075418 ! water homeostasis GO:0030104 12 12 0,000 5,118E-03 0,01074799 ! promoter binding GO:0010843 14 12 0,000 5,118E-03 0,0107418 ! regulation of erythrocyte differentiation GO:0045646 15 12 0,000 5,118E-03 0,01073563 ! intestinal absorption GO:0050892 14 12 0,000 5,118E-03 0,01072946 ! pseudouridine synthase activity GO:0009982 12 12 0,000 5,118E-03 0,0107233 ! oocyte differentiation GO:0009994 13 12 0,000 5,118E-03 0,01071714 ! oxygen transport GO:0015671 13 12 0,000 5,118E-03 0,01071099 GO:0005344|oxygen transporter activity, ! thymus development GO:0048538 13 12 0,000 5,118E-03 0,01070485 ! cholesterol efflux GO:0033344 13 12 0,000 5,118E-03 0,01069871 ! digestive tract morphogenesis GO:0048546 14 12 0,000 5,118E-03 0,01069259 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! racemase and epimerase activity GO:0016854 13 12 0,000 5,118E-03 0,01068647 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 14 12 0,000 5,118E-03 0,01068035 ! tropomyosin binding GO:0005523 12 12 0,000 5,118E-03 0,01067425 ! blastocyst formation GO:0001825 13 12 0,000 5,118E-03 0,01066815 ! regulation of telomere maintenance GO:0032204 16 12 0,000 5,118E-03 0,01066205 ! internal side of plasma membrane GO:0009898 16 12 0,000 5,118E-03 0,01065597 ! mannose binding GO:0005537 13 12 0,000 5,118E-03 0,01064989 ! phosphoprotein binding GO:0051219 14 12 0,000 5,118E-03 0,01064382 ! defense response to fungus GO:0050832 12 12 0,000 5,118E-03 0,01063775 ! embryonic placenta development GO:0001892 16 12 0,000 5,118E-03 0,0106317 ! regulation of steroid biosynthetic process GO:0050810 12 12 0,000 5,118E-03 0,01062564 ! cell wall macromolecule metabolic process GO:0044036 15 12 0,000 5,118E-03 0,0106196 ! acyl-CoA binding GO:0000062 12 12 0,000 5,118E-03 0,01061356 ! cortical cytoskeleton organization GO:0030865 13 12 0,000 5,118E-03 0,01060753 ! regulation of nitric-oxide synthase activity GO:0050999 12 12 0,000 5,118E-03 0,01060151 ! copper ion transport GO:0006825 12 12 0,000 5,118E-03 0,01059549 ! calcium ion transport into cytosol GO:0060402 19 12 0,000 5,118E-03 0,01058948 ! inositol metabolic process GO:0006020 21 12 0,000 5,118E-03 0,01058348 ! vesicle targeting, to, from or within Golgi GO:0048199 13 12 0,000 5,118E-03 0,01057748 ! forelimb morphogenesis GO:0035136 15 12 0,000 5,118E-03 0,01057149 ! protein complex disassembly GO:0043241 15 12 0,000 5,118E-03 0,01056551 GO:0043624|cellular protein complex disassembly, ! ion channel inhibitor activity GO:0008200 15 12 0,000 5,118E-03 0,01055953 GO:0016248|channel inhibitor activity, ! low-density lipoprotein particle GO:0034362 13 12 0,000 5,118E-03 0,01055357 ! lipoprotein particle clearance GO:0034381 14 12 0,000 5,118E-03 0,0105476 ! receptor signaling protein tyrosine kinase activity GO:0004716 14 12 0,000 5,118E-03 0,01054165 ! endothelial cell differentiation GO:0045446 15 12 0,000 5,118E-03 0,0105357 ! exosome (RNase complex) GO:0000178 13 12 0,000 5,118E-03 0,01052976 ! DNA N-glycosylase activity GO:0019104 12 12 0,000 5,118E-03 0,01052382 ! endoderm development GO:0007492 13 12 0,000 5,118E-03 0,01051789 ! positive regulation of Ras protein signal transduction GO:0046579 25 12 0,000 5,118E-03 0,01051197 ! focal adhesion formation GO:0048041 16 12 0,000 5,118E-03 0,01050605 ! T cell receptor complex GO:0042101 31 12 0,000 5,118E-03 0,01050014 ! cellular carbohydrate catabolic process GO:0044275 25 12 0,000 5,118E-03 0,01049424 ! dicarboxylic acid transmembrane transporter activity GO:0005310 14 12 0,000 5,118E-03 0,01048835 ! CoA hydrolase activity GO:0016289 14 12 0,000 5,118E-03 0,01048246 ! histone acetyltransferase complex GO:0000123 14 12 0,000 5,118E-03 0,01047658 ! regulation of alpha-beta T cell differentiation GO:0046637 13 12 0,000 5,118E-03 0,0104707 ! alpha-beta T cell activation GO:0046631 14 12 0,000 5,118E-03 0,01046483 ! retinol binding GO:0019841 12 12 0,000 5,118E-03 0,01045897 ! regulation of organ growth GO:0046620 12 12 0,000 5,118E-03 0,01045311 ! regulation of natural killer cell mediated immunity GO:0002715 13 12 0,000 5,118E-03 0,01044726 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! vasoconstriction GO:0042310 13 12 0,000 5,118E-03 0,01044142 ! histone acetylation GO:0016573 13 12 0,000 5,118E-03 0,01043558 ! ribosome binding GO:0043022 13 12 0,000 5,118E-03 0,01042975 ! delayed rectifier potassium channel activity GO:0005251 14 12 0,000 5,118E-03 0,01042393 ! organic cation transmembrane transporter activity GO:0015101 12 12 0,000 5,118E-03 0,01041811 ! phosphate transmembrane transporter activity GO:0015114 14 12 0,000 5,118E-03 0,0104123 ! tissue regeneration GO:0042246 12 12 0,000 5,118E-03 0,0104065 ! sulfate transmembrane transporter activity GO:0015116 13 12 0,000 5,118E-03 0,0104007 ! adenylyltransferase activity GO:0070566 13 12 0,000 5,118E-03 0,01039491 ! germ cell nucleus GO:0043073 14 12 0,000 5,118E-03 0,01038912 ! trans-Golgi network transport vesicle membrane GO:0012510 16 12 0,000 5,118E-03 0,01038335 ! hexose transmembrane transporter activity GO:0015149 12 12 0,000 5,118E-03 0,01037757 ! hexosaminidase activity GO:0015929 12 12 0,000 5,118E-03 0,01037181 ! regulation of acute inflammatory response GO:0002673 12 12 0,000 5,118E-03 0,01036605 ! activation of NF-kappaB-inducing kinase activity GO:0007250 14 12 0,000 5,118E-03 0,0103603 ! transmembrane receptor protein serine/threonine kinase signaling protein activity GO:0005071 13 12 0,000 5,118E-03 0,01035455 ! dopamine metabolic process GO:0042417 15 12 0,000 5,118E-03 0,01034881 ! somatic diversification of immunoglobulins GO:0016445 12 12 0,000 5,118E-03 0,01034308 ! phosphoinositide 3-kinase activity GO:0035004 14 12 0,000 5,118E-03 0,01033735 ! insulin-like growth factor receptor binding GO:0005159 14 12 0,000 5,118E-03 0,01033163 ! bacterial binding GO:0008367 14 12 0,000 5,118E-03 0,01032592 ! steroid hydroxylase activity GO:0008395 12 12 0,000 5,118E-03 0,01032021 ! cardiac cell differentiation GO:0035051 16 12 0,000 5,118E-03 0,01031451 ! phosphoinositide 3-kinase complex GO:0005942 14 12 0,000 5,118E-03 0,01030881 ! localization within membrane GO:0051668 13 12 0,000 5,118E-03 0,01030312 ! microtubule-based flagellum GO:0009434 12 12 0,000 5,118E-03 0,01029744 ! axoneme part GO:0044447 12 12 0,000 5,118E-03 0,01029176 ! regulation of membrane protein ectodomain proteolysis GO:0051043 14 13 0,000 5,543E-03 0,01114118 ! neuron maturation GO:0042551 14 13 0,000 5,543E-03 0,01113505 ! positive regulation of small GTPase mediated signal transduction GO:0051057 26 13 0,000 5,543E-03 0,01112892 ! negative regulation of bone remodeling GO:0046851 15 13 0,000 5,543E-03 0,0111228 ! bone remodeling GO:0046849 14 13 0,000 5,543E-03 0,01111668 ! nicotinic acetylcholine-gated receptor-channel complex GO:0005892 13 13 0,000 5,543E-03 0,01111058 ! regulation of receptor-mediated endocytosis GO:0048259 15 13 0,000 5,543E-03 0,01110447 ! striated muscle thin filament GO:0005865 14 13 0,000 5,543E-03 0,01109838 ! patterning of blood vessels GO:0001569 15 13 0,000 5,543E-03 0,01109229 ! organelle fusion GO:0048284 16 13 0,000 5,543E-03 0,01108621 ! palate development GO:0060021 15 13 0,000 5,543E-03 0,01108014 ! induction of apoptosis via death domain receptors GO:0008625 16 13 0,000 5,543E-03 0,01107407 ! arginine metabolic process GO:0006525 14 13 0,000 5,543E-03 0,01106801 ! ER-Golgi intermediate compartment membrane GO:0033116 23 13 0,000 5,543E-03 0,01106195 ! tyrosine metabolic process GO:0006570 15 13 0,000 5,543E-03 0,0110559 ! response to retinoic acid GO:0032526 17 13 0,000 5,543E-03 0,01104986 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 15 13 0,000 5,543E-03 0,01104383 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lipase inhibitor activity GO:0055102 14 13 0,000 5,543E-03 0,0110378 ! negative regulation of endothelial cell migration GO:0010596 15 13 0,000 5,543E-03 0,01103178 ! fear response GO:0042596 15 13 0,000 5,543E-03 0,01102576 ! epithelial cell development GO:0002064 22 13 0,000 5,543E-03 0,01101975 ! branching involved in ureteric bud morphogenesis GO:0001658 14 13 0,000 5,543E-03 0,01101375 GO:0060675|ureteric bud morphogenesis, ! positive regulation of fatty acid metabolic process GO:0045923 14 13 0,000 5,543E-03 0,01100776 ! protein kinase activator activity GO:0030295 17 13 0,000 5,543E-03 0,01100177 ! heparan sulfate proteoglycan metabolic process GO:0030201 13 13 0,000 5,543E-03 0,01099578 ! positive regulation of foam cell differentiation GO:0010744 16 13 0,000 5,543E-03 0,01098981 ! protein targeting to peroxisome GO:0006625 13 13 0,000 5,543E-03 0,01098384 ! NLS-bearing substrate import into nucleus GO:0006607 15 13 0,000 5,543E-03 0,01097788 ! cranial nerve development GO:0021545 15 13 0,000 5,543E-03 0,01097192 ! eye photoreceptor cell differentiation GO:0001754 17 13 0,000 5,543E-03 0,01096597 GO:0042462|eye photoreceptor cell development, ! DNA-directed RNA polymerase II, core complex GO:0005665 14 13 0,000 5,543E-03 0,01096003 ! cerebellum morphogenesis GO:0021587 15 13 0,000 5,543E-03 0,01095409 ! MHC class I receptor activity GO:0032393 20 13 0,000 5,543E-03 0,01094816 ! exoribonuclease activity GO:0004532 13 13 0,000 5,543E-03 0,01094223 GO:0016896|exoribonuclease activity, producing 5'-phosphomonoesters, ! intrinsic to peroxisomal membrane GO:0031231 13 13 0,000 5,543E-03 0,01093632 ! COPI-coated vesicle GO:0030137 15 13 0,000 5,543E-03 0,0109304 ! cofactor transporter activity GO:0051184 15 13 0,000 5,543E-03 0,0109245 ! NADP metabolic process GO:0006739 15 13 0,000 5,543E-03 0,0109186 ! negative regulation of macrophage differentiation GO:0045650 16 13 0,000 5,543E-03 0,01091271 ! regulation of osteoclast differentiation GO:0045670 15 13 0,000 5,543E-03 0,01090682 ! aromatic amino acid family catabolic process GO:0009074 13 13 0,000 5,543E-03 0,01090094 ! eukaryotic cell surface binding GO:0043499 15 13 0,000 5,543E-03 0,01089507 ! proximal/distal pattern formation GO:0009954 15 13 0,000 5,543E-03 0,0108892 ! positive regulation of JNK cascade GO:0046330 17 13 0,000 5,543E-03 0,01088334 ! positive regulation of glucose import GO:0046326 16 13 0,000 5,543E-03 0,01087749 GO:0010828|positive regulation of glucose transport, ! epithelial to mesenchymal transition GO:0001837 13 13 0,000 5,543E-03 0,01087164 ! ADP binding GO:0043531 15 13 0,000 5,543E-03 0,0108658 ! defense response to Gram-positive bacterium GO:0050830 14 13 0,000 5,543E-03 0,01085996 ! mismatched DNA binding GO:0030983 13 13 0,000 5,543E-03 0,01085413 ! positive regulation of synaptic transmission GO:0050806 15 13 0,000 5,543E-03 0,01084831 ! neuron fate specification GO:0048665 25 13 0,000 5,543E-03 0,01084249 ! N-terminal protein amino acid modification GO:0031365 14 13 0,000 5,543E-03 0,01083668 ! dicarboxylic acid transport GO:0006835 15 13 0,000 5,543E-03 0,01083088 ! water transport GO:0006833 18 13 0,000 5,543E-03 0,01082508 GO:0042044|fluid transport, ! replisome GO:0030894 24 13 0,000 5,543E-03 0,01081929 GO:0043601|nuclear replisome, ! cytosolic calcium ion transport GO:0060401 20 13 0,000 5,543E-03 0,0108135 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 5,543E-03 0,01080772 ! inorganic anion exchanger activity GO:0005452 13 13 0,000 5,543E-03 0,01080195 ! negative regulation of ion transport GO:0043271 15 13 0,000 5,543E-03 0,01079618 ! retinoic acid receptor binding GO:0042974 14 13 0,000 5,543E-03 0,01079042 ! blood vessel remodeling GO:0001974 16 13 0,000 5,543E-03 0,01078467 ! myoblast differentiation GO:0045445 15 13 0,000 5,543E-03 0,01077892 ! ventral spinal cord development GO:0021517 16 13 0,000 5,543E-03 0,01077317 ! prenyltransferase activity GO:0004659 15 13 0,000 5,543E-03 0,01076744 ! activation of MAPKK activity GO:0000186 13 13 0,000 5,543E-03 0,01076171 ! protein histidine kinase activity GO:0004673 15 13 0,000 5,543E-03 0,01075598 GO:0000155|two-component sensor activity, ! cullin-RING ubiquitin ligase complex GO:0031461 13 13 0,000 5,543E-03 0,01075026 ! regulation of skeletal muscle fiber development GO:0048742 16 13 0,000 5,543E-03 0,01074455 ! acyl-CoA dehydrogenase activity GO:0003995 14 13 0,000 5,543E-03 0,01073885 ! exocrine system development GO:0035272 14 13 0,000 5,543E-03 0,01073315 ! membrane protein proteolysis GO:0033619 14 13 0,000 5,543E-03 0,01072745 GO:0006509|membrane protein ectodomain proteolysis, ! organic alcohol transport GO:0015850 17 13 0,000 5,543E-03 0,01072176 ! calcium ion transmembrane transporter activity GO:0015085 15 13 0,000 5,543E-03 0,01071608 ! L-glutamate transport GO:0015813 14 13 0,000 5,543E-03 0,01071041 GO:0015800|acidic amino acid transport, ! embryo implantation GO:0007566 17 13 0,000 5,543E-03 0,01070474 ! G1/S transition checkpoint GO:0031575 14 13 0,000 5,543E-03 0,01069907 ! immunoglobulin binding GO:0019865 14 13 0,000 5,543E-03 0,01069341 ! negative regulation of protein import into nucleus GO:0042308 13 13 0,000 5,543E-03 0,01068776 ! regulation of T cell mediated immunity GO:0002709 17 13 0,000 5,543E-03 0,01068212 ! DNA unwinding during replication GO:0006268 14 13 0,000 5,543E-03 0,01067648 ! genitalia development GO:0048806 18 13 0,000 5,543E-03 0,01067084 ! regulation of interleukin-8 production GO:0032677 15 13 0,000 5,543E-03 0,01066521 ! regulation of interleukin-12 production GO:0032655 13 13 0,000 5,543E-03 0,01065959 ! MHC class I protein binding GO:0042288 23 13 0,000 5,543E-03 0,01065398 ! histone deacetylation GO:0016575 14 13 0,000 5,543E-03 0,01064837 ! calcium channel regulator activity GO:0005246 16 13 0,000 5,543E-03 0,01064276 ! DNA methylation GO:0006306 15 13 0,000 5,543E-03 0,01063716 GO:0006305|DNA alkylation, ! mRNA splice site selection GO:0006376 17 13 0,000 5,543E-03 0,01063157 ! chromatin silencing GO:0006342 13 13 0,000 5,543E-03 0,01062598 ! serotonin receptor activity GO:0004993 16 13 0,000 5,543E-03 0,0106204 ! monosaccharide transmembrane transporter activity GO:0015145 13 13 0,000 5,543E-03 0,01061483 ! T cell homeostasis GO:0043029 14 13 0,000 5,543E-03 0,01060926 ! peptide biosynthetic process GO:0043043 14 13 0,000 5,543E-03 0,0106037 ! diacylglycerol kinase activity GO:0004143 15 13 0,000 5,543E-03 0,01059814 ! response to gamma radiation GO:0010332 14 13 0,000 5,543E-03 0,01059259 ! synaptic transmission, cholinergic GO:0007271 14 13 0,000 5,543E-03 0,01058704 ! retinoic acid receptor activity GO:0003708 15 13 0,000 5,543E-03 0,0105815 ! purine base metabolic process GO:0006144 15 13 0,000 5,543E-03 0,01057597 ! cAMP binding GO:0030552 15 13 0,000 5,543E-03 0,01057044 ! biogenic amine catabolic process GO:0042402 14 13 0,000 5,543E-03 0,01056492 ! negative regulation of BMP signaling pathway GO:0030514 14 13 0,000 5,543E-03 0,0105594 ! regulation of axon extension GO:0030516 16 13 0,000 5,543E-03 0,01055389 ! drug transporter activity GO:0015238 14 13 0,000 5,543E-03 0,01054838 ! regulation of NF-kappaB import into nucleus GO:0042345 14 13 0,000 5,543E-03 0,01054288 ! calcium-activated potassium channel activity GO:0015269 15 13 0,000 5,543E-03 0,01053739 ! response to cold GO:0009409 13 13 0,000 5,543E-03 0,0105319 ! cadherin binding GO:0045296 16 13 0,000 5,543E-03 0,01052642 ! nucleolar part GO:0044452 13 13 0,000 5,543E-03 0,01052094 ! tRNA modification GO:0006400 14 14 0,000 5,968E-03 0,01132223 ! cis-Golgi network GO:0005801 16 14 0,000 5,968E-03 0,01131635 ! negative regulation of hormone secretion GO:0046888 14 14 0,000 5,968E-03 0,01131047 ! 'de novo' protein folding GO:0006458 14 14 0,000 5,968E-03 0,0113046 ! organellar large ribosomal subunit GO:0000315 15 14 0,000 5,968E-03 0,01129873 GO:0005762|mitochondrial large ribosomal subunit, ! phosphoinositide phosphorylation GO:0046854 18 14 0,000 5,968E-03 0,01129287 ! peroxisomal transport GO:0043574 14 14 0,000 5,968E-03 0,01128702 ! cardiac muscle contraction GO:0060048 15 14 0,000 5,968E-03 0,01128117 ! dopamine receptor signaling pathway GO:0007212 19 14 0,000 5,968E-03 0,01127533 ! mechanoreceptor differentiation GO:0042490 16 14 0,000 5,968E-03 0,01126949 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 18 14 0,000 5,968E-03 0,01126366 ! pseudouridine synthesis GO:0001522 14 14 0,000 5,968E-03 0,01125784 ! caspase activator activity GO:0008656 16 14 0,000 5,968E-03 0,01125202 ! MHC class II protein complex GO:0042613 19 14 0,000 5,968E-03 0,01124621 ! regulation of defense response to virus GO:0050688 24 14 0,000 5,968E-03 0,0112404 ! cAMP-dependent protein kinase regulator activity GO:0008603 17 14 0,000 5,968E-03 0,0112346 ! cation:cation antiporter activity GO:0015491 14 14 0,000 5,968E-03 0,01122881 ! glycoprotein catabolic process GO:0006516 16 14 0,000 5,968E-03 0,01122302 ! protein polyubiquitination GO:0000209 15 14 0,000 5,968E-03 0,01121724 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 34 14 0,000 5,968E-03 0,01121146 ! cell-cell junction assembly GO:0007043 15 14 0,000 5,968E-03 0,01120569 ! response to vitamin A GO:0033189 18 14 0,000 5,968E-03 0,01119993 ! actin filament bundle formation GO:0051017 16 14 0,000 5,968E-03 0,01119417 ! regulation of lipoprotein lipase activity GO:0051004 15 14 0,000 5,968E-03 0,01118842 ! plasma membrane fusion GO:0045026 15 14 0,000 5,968E-03 0,01118267 ! purine nucleoside monophosphate metabolic process GO:0009126 15 14 0,000 5,968E-03 0,01117693 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of viral reproduction GO:0050792 16 14 0,000 5,968E-03 0,01117119 ! protein export from nucleus GO:0006611 14 14 0,000 5,968E-03 0,01116547 ! presynaptic membrane GO:0042734 14 14 0,000 5,968E-03 0,01115974 ! negative regulation of immune response GO:0050777 21 14 0,000 5,968E-03 0,01115403 ! gastrulation with mouth forming second GO:0001702 15 14 0,000 5,968E-03 0,01114831 ! neural crest cell migration GO:0001755 15 14 0,000 5,968E-03 0,01114261 ! anaphase-promoting complex GO:0005680 17 14 0,000 5,968E-03 0,01113691 ! positive regulation of oxidoreductase activity GO:0051353 14 14 0,000 5,968E-03 0,01113122 ! negative regulation of protein secretion GO:0050709 17 14 0,000 5,968E-03 0,01112553 ! cofactor transport GO:0051181 16 14 0,000 5,968E-03 0,01111985 ! C21-steroid hormone biosynthetic process GO:0006700 14 14 0,000 5,968E-03 0,01111417 ! protein-chromophore linkage GO:0018298 16 14 0,000 5,968E-03 0,0111085 ! cobalt ion binding GO:0050897 14 14 0,000 5,968E-03 0,01110283 ! glutamine family amino acid biosynthetic process GO:0009084 16 14 0,000 5,968E-03 0,01109718 ! positive regulation of transmission of nerve impulse GO:0051971 16 14 0,000 5,968E-03 0,01109152 ! aspartate family amino acid biosynthetic process GO:0009067 17 14 0,000 5,968E-03 0,01108587 ! gas transport GO:0015669 15 14 0,000 5,968E-03 0,01108023 ! pyridine nucleotide biosynthetic process GO:0019363 15 14 0,000 5,968E-03 0,0110746 ! heme biosynthetic process GO:0006783 14 14 0,000 5,968E-03 0,01106897 ! cerebellar cortex development GO:0021695 16 14 0,000 5,968E-03 0,01106334 ! insulin secretion GO:0030073 17 14 0,000 5,968E-03 0,01105772 ! tRNA binding GO:0000049 16 14 0,000 5,968E-03 0,01105211 ! positive regulation of cell killing GO:0031343 16 14 0,000 5,968E-03 0,0110465 ! positive regulation of protein complex assembly GO:0031334 14 14 0,000 5,968E-03 0,0110409 ! G1 phase of mitotic cell cycle GO:0000080 15 14 0,000 5,968E-03 0,01103531 ! phosphatidylinositol metabolic process GO:0046488 15 14 0,000 5,968E-03 0,01102972 ! regulation of B cell proliferation GO:0030888 18 14 0,000 5,968E-03 0,01102413 ! regulation of neuronal synaptic plasticity GO:0048168 24 14 0,000 5,968E-03 0,01101855 ! MAP kinase activity GO:0004707 16 14 0,000 5,968E-03 0,01101298 ! cytokine biosynthetic process GO:0042089 14 14 0,000 5,968E-03 0,01100741 ! mannosyltransferase activity GO:0000030 14 14 0,000 5,968E-03 0,01100185 ! isoprenoid biosynthetic process GO:0008299 17 14 0,000 5,968E-03 0,01099629 ! C-C chemokine binding GO:0019957 15 14 0,000 5,968E-03 0,01099074 GO:0016493|C-C chemokine receptor activity, ! cardiac muscle tissue development GO:0048738 16 14 0,000 5,968E-03 0,0109852 ! complement activation, alternative pathway GO:0006957 14 14 0,000 5,968E-03 0,01097966 ! response to osmotic stress GO:0006970 17 14 0,000 5,968E-03 0,01097412 ! fructose metabolic process GO:0006000 15 14 0,000 5,968E-03 0,01096859 ! telomeric DNA binding GO:0042162 17 14 0,000 5,968E-03 0,01096307 ! monoamine transport GO:0015844 15 14 0,000 5,968E-03 0,01095755 ! regulation of pathway-restricted SMAD protein phosphorylation GO:0060393 14 14 0,000 5,968E-03 0,01095204 ! nucleoside kinase activity GO:0019206 17 14 0,000 5,968E-03 0,01094653 ! dendritic spine GO:0043197 15 14 0,000 5,968E-03 0,01094103 ! stem cell development GO:0048864 14 14 0,000 5,968E-03 0,01093554 GO:0019827|stem cell maintenance, ! regulation of alpha-beta T cell activation GO:0046634 15 14 0,000 5,968E-03 0,01093005 ! regulation of insulin receptor signaling pathway GO:0046626 17 14 0,000 5,968E-03 0,01092456 ! regulation of cytokine production during immune response GO:0002718 15 14 0,000 5,968E-03 0,01091909 ! positive regulation of protein import into nucleus GO:0042307 16 14 0,000 5,968E-03 0,01091361 ! regulation of cellular pH GO:0030641 14 14 0,000 5,968E-03 0,01090815 ! regulation of monooxygenase activity GO:0032768 14 14 0,000 5,968E-03 0,01090268 ! intracellular ligand-gated ion channel activity GO:0005217 14 14 0,000 5,968E-03 0,01089723 ! sarcoplasmic reticulum membrane GO:0033017 16 14 0,000 5,968E-03 0,01089177 ! detection of biotic stimulus GO:0009595 16 14 0,000 5,968E-03 0,01088633 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity GO:0015932 16 14 0,000 5,968E-03 0,01088089 ! mannosidase activity GO:0015923 19 14 0,000 5,968E-03 0,01087545 ! calcium-dependent cysteine-type endopeptidase activity GO:0004198 17 14 0,000 5,968E-03 0,01087002 ! negative regulation of tissue remodeling GO:0034104 16 14 0,000 5,968E-03 0,0108646 ! positive regulation of bone mineralization GO:0030501 14 14 0,000 5,968E-03 0,01085918 ! neuromuscular synaptic transmission GO:0007274 15 14 0,000 5,968E-03 0,01085377 ! regulation of immunoglobulin production GO:0002637 15 14 0,000 5,968E-03 0,01084836 ! cAMP biosynthetic process GO:0006171 14 14 0,000 5,968E-03 0,01084296 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 16 14 0,000 5,968E-03 0,01083756 ! fucosyltransferase activity GO:0008417 16 14 0,000 5,968E-03 0,01083217 ! sperm-egg recognition GO:0035036 17 14 0,000 5,968E-03 0,01082678 GO:0007339|binding of sperm to zona pellucida, ! defense response to virus GO:0051607 21 14 0,000 5,968E-03 0,0108214 ! SWI/SNF-type complex GO:0070603 16 14 0,000 5,968E-03 0,01081602 GO:0016514|SWI/SNF complex, ! aldo-keto reductase activity GO:0004033 15 14 0,000 5,968E-03 0,01081065 ! positive regulation of translation GO:0045727 17 15 0,000 6,393E-03 0,01157493 ! nuclear replication fork GO:0043596 26 15 0,000 6,393E-03 0,01156919 ! transferase activity, transferring amino-acyl groups GO:0016755 15 15 0,000 6,393E-03 0,01156345 ! 2'-deoxyribonucleotide metabolic process GO:0009394 16 15 0,000 6,393E-03 0,01155772 GO:0019692|deoxyribose phosphate metabolic process, ! phospholipid catabolic process GO:0009395 26 15 0,000 6,393E-03 0,011552 ! endothelial cell migration GO:0043542 16 15 0,000 6,393E-03 0,01154628 ! lipid phosphorylation GO:0046834 19 15 0,000 6,393E-03 0,01154057 ! negative regulation of nucleocytoplasmic transport GO:0046823 15 15 0,000 6,393E-03 0,01153486 ! response to vitamin GO:0033273 19 15 0,000 6,393E-03 0,01152916 ! gene silencing by RNA GO:0031047 17 15 0,000 6,393E-03 0,01152346 ! striated muscle thick filament GO:0005863 16 15 0,000 6,393E-03 0,01151777 GO:0032982|myosin filament, ! cellular response to hydrogen peroxide GO:0070301 15 15 0,000 6,393E-03 0,01151209 GO:0042744|hydrogen peroxide catabolic process, ! endocrine pancreas development GO:0031018 16 15 0,000 6,393E-03 0,01150641 ! regulation of interleukin-2 biosynthetic process GO:0045076 15 15 0,000 6,393E-03 0,01150073 ! glutamate metabolic process GO:0006536 17 15 0,000 6,393E-03 0,01149507 ! pituitary gland development GO:0021983 16 15 0,000 6,393E-03 0,0114894 ! cholesterol binding GO:0015485 15 15 0,000 6,393E-03 0,01148375 ! NAD metabolic process GO:0019674 17 15 0,000 6,393E-03 0,01147809 ! protease binding GO:0002020 20 15 0,000 6,393E-03 0,01147245 ! regulation of heart rate GO:0002027 20 15 0,000 6,393E-03 0,01146681 ! actin filament bundle GO:0032432 18 15 0,000 6,393E-03 0,01146117 GO:0001725|stress fiber, ! Golgi cisterna GO:0031985 17 15 0,000 6,393E-03 0,01145554 ! regulation of exocytosis GO:0017157 16 15 0,000 6,393E-03 0,01144992 ! positive regulation of axonogenesis GO:0050772 16 15 0,000 6,393E-03 0,0114443 ! embryonic digit morphogenesis GO:0042733 17 15 0,000 6,393E-03 0,01143869 ! positive regulation of biomineral formation GO:0070169 15 15 0,000 6,393E-03 0,01143308 ! prostaglandin metabolic process GO:0006693 15 15 0,000 6,393E-03 0,01142748 GO:0006692|prostanoid metabolic process, ! postsynaptic density GO:0014069 20 15 0,000 6,393E-03 0,01142188 ! neuron recognition GO:0008038 18 15 0,000 6,393E-03 0,01141629 ! hindbrain morphogenesis GO:0021575 18 15 0,000 6,393E-03 0,01141071 ! filopodium GO:0030175 17 15 0,000 6,393E-03 0,01140513 ! negative regulation of blood coagulation GO:0030195 18 15 0,000 6,393E-03 0,01139955 ! folic acid and derivative metabolic process GO:0006760 15 15 0,000 6,393E-03 0,01139399 ! positive regulation of neuron differentiation GO:0045666 27 15 0,000 6,393E-03 0,01138842 ! peptide hormone binding GO:0017046 16 15 0,000 6,393E-03 0,01138286 ! regulation of ATPase activity GO:0043462 17 15 0,000 6,393E-03 0,01137731 ! endoribonuclease activity, producing 3'-phosphomonoesters GO:0016892 16 15 0,000 6,393E-03 0,01137176 ! regulation of leukocyte mediated cytotoxicity GO:0001910 21 15 0,000 6,393E-03 0,01136622 ! acid-thiol ligase activity GO:0016878 16 15 0,000 6,393E-03 0,01136069 ! aromatic compound biosynthetic process GO:0019438 25 15 0,000 6,393E-03 0,01135515 ! positive regulation of calcium ion transport GO:0051928 20 15 0,000 6,393E-03 0,01134963 ! dystrophin-associated glycoprotein complex GO:0016010 17 15 0,000 6,393E-03 0,01134411 ! RNA 3'-end processing GO:0031123 16 15 0,000 6,393E-03 0,01133859 ! developmental induction GO:0031128 17 15 0,000 6,393E-03 0,01133308 GO:0045168|cell-cell signaling involved in cell fate specification, ! protein import into nucleus, docking GO:0000059 15 15 0,000 6,393E-03 0,01132758 ! regulation of skeletal muscle tissue development GO:0048641 18 15 0,000 6,393E-03 0,01132208 ! lactation GO:0007595 17 15 0,000 6,393E-03 0,01131659 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 16 15 0,000 6,393E-03 0,0113111 GO:0016444|somatic cell DNA recombination, ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 6,393E-03 0,01130562 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 6,393E-03 0,01130014 ! double-strand break repair via homologous recombination GO:0000724 36 15 0,000 6,393E-03 0,01129467 GO:0000725|recombinational repair, ! phosphatidylcholine metabolic process GO:0046470 16 15 0,000 6,393E-03 0,0112892 ! regulation of cell-cell adhesion GO:0022407 18 15 0,000 6,393E-03 0,01128374 ! sulfate transport GO:0008272 16 15 0,000 6,393E-03 0,01127828 ! hindlimb morphogenesis GO:0035137 17 15 0,000 6,393E-03 0,01127283 ! bile acid metabolic process GO:0008206 17 15 0,000 6,393E-03 0,01126739 ! very-low-density lipoprotein particle GO:0034361 16 15 0,000 6,393E-03 0,01126194 GO:0034385|triglyceride-rich lipoprotein particle, ! adult walking behavior GO:0007628 19 15 0,000 6,393E-03 0,01125651 ! 2 iron, 2 sulfur cluster binding GO:0051537 16 15 0,000 6,393E-03 0,01125108 ! heart looping GO:0001947 18 15 0,000 6,393E-03 0,01124565 ! protein kinase C activity GO:0004697 17 15 0,000 6,393E-03 0,01124023 ! oligodendrocyte differentiation GO:0048709 15 15 0,000 6,393E-03 0,01123482 ! regulation of striated muscle contraction GO:0006942 18 15 0,000 6,393E-03 0,01122941 ! pigmentation during development GO:0048066 17 15 0,000 6,393E-03 0,01122401 ! cytokine metabolic process GO:0042107 15 15 0,000 6,393E-03 0,01121861 ! vesicle coating GO:0006901 17 15 0,000 6,393E-03 0,01121322 ! disulfide oxidoreductase activity GO:0015036 16 15 0,000 6,393E-03 0,01120783 ! neutral amino acid transport GO:0015804 18 15 0,000 6,393E-03 0,01120244 ! L-amino acid transport GO:0015807 16 15 0,000 6,393E-03 0,01119707 ! microfilament motor activity GO:0000146 15 15 0,000 6,393E-03 0,01119169 ! carbonate dehydratase activity GO:0004089 18 15 0,000 6,393E-03 0,01118632 ! regulation of vasodilation GO:0042312 25 15 0,000 6,393E-03 0,01118096 ! DNA replication initiation GO:0006270 15 15 0,000 6,393E-03 0,0111756 ! taste receptor activity GO:0008527 15 15 0,000 6,393E-03 0,01117025 ! cellular pigmentation GO:0033059 16 15 0,000 6,393E-03 0,01116491 ! voltage-gated chloride channel activity GO:0005247 18 15 0,000 6,393E-03 0,01115956 ! voltage-gated sodium channel activity GO:0005248 18 15 0,000 6,393E-03 0,01115423 ! long-chain fatty acid transport GO:0015909 17 15 0,000 6,393E-03 0,01114889 ! positive regulation of neurological system process GO:0031646 18 15 0,000 6,393E-03 0,01114357 ! nerve-nerve synaptic transmission GO:0007270 17 15 0,000 6,393E-03 0,01113825 ! ARF guanyl-nucleotide exchange factor activity GO:0005086 17 15 0,000 6,393E-03 0,01113293 ! ion gated channel activity GO:0022839 17 15 0,000 6,393E-03 0,01112762 ! heterogeneous nuclear ribonucleoprotein complex GO:0030530 15 15 0,000 6,393E-03 0,01112231 ! receptor activator activity GO:0030546 17 15 0,000 6,393E-03 0,01111701 ! protein transmembrane transporter activity GO:0008320 16 15 0,000 6,393E-03 0,01111171 ! negative regulation of mast cell proliferation GO:0070667 16 15 0,000 6,393E-03 0,01110642 GO:0042130|negative regulation of T cell proliferation, ! acylglycerol O-acyltransferase activity GO:0016411 16 15 0,000 6,393E-03 0,01110114 ! triacylglycerol lipase activity GO:0004806 16 15 0,000 6,393E-03 0,01109586 ! peptide hormone processing GO:0016486 19 15 0,000 6,393E-03 0,01109058 ! phospholipid-translocating ATPase activity GO:0004012 16 15 0,000 6,393E-03 0,01108531 GO:0015247|aminophospholipid transporter activity, ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 19 16 0,000 6,818E-03 0,0118165 ! positive regulation of anti-apoptosis GO:0045768 16 16 0,000 6,818E-03 0,01181089 ! phosphotransferase activity, nitrogenous group as acceptor GO:0016775 18 16 0,000 6,818E-03 0,01180529 ! heterophilic cell adhesion GO:0007157 17 16 0,000 6,818E-03 0,01179969 ! gamma-aminobutyric acid signaling pathway GO:0007214 17 16 0,000 6,818E-03 0,01179409 ! kinesin complex GO:0005871 16 16 0,000 6,818E-03 0,0117885 ! photoreceptor cell development GO:0042461 22 16 0,000 6,818E-03 0,01178292 GO:0046530|photoreceptor cell differentiation, ! negative regulation of gene expression, epigenetic GO:0045814 16 16 0,000 6,818E-03 0,01177734 ! mitotic chromosome condensation GO:0007076 17 16 0,000 6,818E-03 0,01177176 ! centrosome cycle GO:0007098 26 16 0,000 6,818E-03 0,0117662 ! negative regulation of epithelial cell proliferation GO:0050680 18 16 0,000 6,818E-03 0,01176063 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 16 0,000 6,818E-03 0,01175507 ! DNA duplex unwinding GO:0032508 17 16 0,000 6,818E-03 0,01174952 GO:0032392|DNA geometric change, ! cerebral cortex development GO:0021987 16 16 0,000 6,818E-03 0,01174397 ! lysosomal transport GO:0007041 16 16 0,000 6,818E-03 0,01173843 ! transforming growth factor beta receptor activity GO:0005024 18 16 0,000 6,818E-03 0,01173289 GO:0004675|transmembrane receptor protein serine/threonine kinase activity, ! rough endoplasmic reticulum GO:0005791 16 16 0,000 6,818E-03 0,01172736 ! mitochondrial proton-transporting ATP synthase complex GO:0005753 16 16 0,000 6,818E-03 0,01172184 ! small nucleolar ribonucleoprotein complex GO:0005732 16 16 0,000 6,818E-03 0,01171631 ! myofibril assembly GO:0030239 17 16 0,000 6,818E-03 0,0117108 GO:0055002|striated muscle cell development, ! G1 phase GO:0051318 17 16 0,000 6,818E-03 0,01170529 ! receptor signaling complex scaffold activity GO:0030159 19 16 0,000 6,818E-03 0,01169978 ! negative regulation of inflammatory response GO:0050728 17 16 0,000 6,818E-03 0,01169428 ! clathrin vesicle coat GO:0030125 20 16 0,000 6,818E-03 0,01168879 ! endodeoxyribonuclease activity GO:0004520 43 16 0,000 6,818E-03 0,0116833 ! sphingolipid catabolic process GO:0030149 18 16 0,000 6,818E-03 0,01167781 GO:0046466|membrane lipid catabolic process, ! natural killer cell activation GO:0030101 17 16 0,000 6,818E-03 0,01167233 ! steroid catabolic process GO:0006706 18 16 0,000 6,818E-03 0,01166686 ! branched chain family amino acid metabolic process GO:0009081 18 16 0,000 6,818E-03 0,01166139 ! cell-cell recognition GO:0009988 19 16 0,000 6,818E-03 0,01165592 ! somatic diversification of immune receptors GO:0002200 17 16 0,000 6,818E-03 0,01165046 ! spleen development GO:0048536 19 16 0,000 6,818E-03 0,01164501 ! lymphocyte homeostasis GO:0002260 17 16 0,000 6,818E-03 0,01163956 ! regulation of fatty acid oxidation GO:0046320 19 16 0,000 6,818E-03 0,01163411 ! neural tube closure GO:0001843 19 16 0,000 6,818E-03 0,01162868 GO:0060606|tube closure, ! antigen receptor-mediated signaling pathway GO:0050851 22 16 0,000 6,818E-03 0,01162324 ! regulation of glucose metabolic process GO:0010906 18 16 0,000 6,818E-03 0,01161781 ! G2/M transition of mitotic cell cycle GO:0000086 22 16 0,000 6,818E-03 0,01161239 ! regulation of lipid catabolic process GO:0050994 18 16 0,000 6,818E-03 0,01160697 ! viral genome replication GO:0019079 16 16 0,000 6,818E-03 0,01160156 ! regulation of neurotransmitter transport GO:0051588 19 16 0,000 6,818E-03 0,01159615 ! memory GO:0007613 18 16 0,000 6,818E-03 0,01159074 ! regulation of carbohydrate biosynthetic process GO:0043255 17 16 0,000 6,818E-03 0,01158535 ! positive regulation of ion transport GO:0043270 21 16 0,000 6,818E-03 0,01157995 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 18 16 0,000 6,818E-03 0,01157456 ! glycoprotein binding GO:0001948 19 16 0,000 6,818E-03 0,01156918 ! negative regulation of endothelial cell proliferation GO:0001937 17 16 0,000 6,818E-03 0,0115638 ! syntaxin binding GO:0019905 18 16 0,000 6,818E-03 0,01155843 ! myosin binding GO:0017022 17 16 0,000 6,818E-03 0,01155306 ! epidermis morphogenesis GO:0048730 18 16 0,000 6,818E-03 0,0115477 ! fucose metabolic process GO:0006004 18 16 0,000 6,818E-03 0,01154234 ! actin polymerization or depolymerization GO:0008154 18 16 0,000 6,818E-03 0,01153698 ! membrane budding GO:0006900 18 16 0,000 6,818E-03 0,01153163 ! preassembly of GPI anchor in ER membrane GO:0016254 18 16 0,000 6,818E-03 0,01152629 ! intermediate filament cytoskeleton organization GO:0045104 16 16 0,000 6,818E-03 0,01152095 ! behavioral interaction between organisms GO:0051705 19 16 0,000 6,818E-03 0,01151562 ! nucleotide-excision repair, DNA gap filling GO:0006297 19 16 0,000 6,818E-03 0,01151029 ! anchored to plasma membrane GO:0046658 20 16 0,000 6,818E-03 0,01150497 ! calcium activated cation channel activity GO:0005227 18 16 0,000 6,818E-03 0,01149965 ! DNA fragmentation involved in apoptosis GO:0006309 18 16 0,000 6,818E-03 0,01149433 ! apoptotic protease activator activity GO:0016505 18 16 0,000 6,818E-03 0,01148902 ! sulfuric ester hydrolase activity GO:0008484 18 16 0,000 6,818E-03 0,01148372 ! nicotinic acetylcholine-activated cation-selective channel activity GO:0004889 18 16 0,000 6,818E-03 0,01147842 ! purine nucleotide catabolic process GO:0006195 16 16 0,000 6,818E-03 0,01147313 ! RNA polymerase II transcription mediator activity GO:0016455 19 16 0,000 6,818E-03 0,01146784 ! axoneme GO:0005930 16 16 0,000 6,818E-03 0,01146255 ! negative regulation of homeostatic process GO:0032845 19 16 0,000 6,818E-03 0,01145727 ! anion exchanger activity GO:0015380 17 17 0,000 7,243E-03 0,01216547 ! positive regulation of hormone secretion GO:0046887 19 17 0,000 7,243E-03 0,01215987 ! phosphotransferase activity, for other substituted phosphate groups GO:0016780 17 17 0,000 7,243E-03 0,01215428 ! transcription from RNA polymerase III promoter GO:0006383 18 17 0,000 7,243E-03 0,01214869 ! glial cell development GO:0021782 17 17 0,000 7,243E-03 0,01214311 ! limbic system development GO:0021761 18 17 0,000 7,243E-03 0,01213753 ! protein phosphatase type 2A regulator activity GO:0008601 19 17 0,000 7,243E-03 0,01213196 ! pyrimidine ribonucleotide metabolic process GO:0009218 20 17 0,000 7,243E-03 0,01212639 ! ephrin receptor activity GO:0005003 21 17 0,000 7,243E-03 0,01212083 ! acetylcholine receptor activity GO:0015464 18 17 0,000 7,243E-03 0,01211527 ! glutamine metabolic process GO:0006541 26 17 0,000 7,243E-03 0,01210972 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor GO:0016646 21 17 0,000 7,243E-03 0,01210417 ! oxidoreductase activity, acting on the CH-NH2 group of donors GO:0016638 37 17 0,000 7,243E-03 0,01209863 ! signal sequence binding GO:0005048 18 17 0,000 7,243E-03 0,01209309 ! cell-substrate junction assembly GO:0007044 21 17 0,000 7,243E-03 0,01208756 ! proton-transporting two-sector ATPase complex, catalytic domain GO:0033178 17 17 0,000 7,243E-03 0,01208203 ! organelle subcompartment GO:0031984 19 17 0,000 7,243E-03 0,01207651 ! regulation of vasoconstriction GO:0019229 21 17 0,000 7,243E-03 0,01207099 ! membrane depolarization GO:0051899 19 17 0,000 7,243E-03 0,01206548 ! oogenesis GO:0048477 20 17 0,000 7,243E-03 0,01205998 ! nuclear outer membrane GO:0005640 21 17 0,000 7,243E-03 0,01205447 ! regulation of immunoglobulin mediated immune response GO:0002889 18 17 0,000 7,243E-03 0,01204898 GO:0002712|regulation of B cell mediated immunity, ! immunoglobulin production GO:0002377 21 17 0,000 7,243E-03 0,01204348 GO:0002440|production of molecular mediator of immune response, ! positive regulation of cellular carbohydrate metabolic process GO:0010676 18 17 0,000 7,243E-03 0,012038 ! positive regulation of macrophage differentiation GO:0045651 21 17 0,000 7,243E-03 0,01203252 ! organic cation transport GO:0015695 17 17 0,000 7,243E-03 0,01202704 ! porphyrin biosynthetic process GO:0006779 17 17 0,000 7,243E-03 0,01202157 GO:0033014|tetrapyrrole biosynthetic process, ! phosphatidylinositol binding GO:0005545 21 17 0,000 7,243E-03 0,0120161 ! hyaluronic acid binding GO:0005540 19 17 0,000 7,243E-03 0,01201064 ! regulation of mitotic metaphase/anaphase transition GO:0030071 18 17 0,000 7,243E-03 0,01200518 ! negative regulation of coagulation GO:0050819 20 17 0,000 7,243E-03 0,01199973 ! cellular monovalent inorganic cation homeostasis GO:0030004 18 17 0,000 7,243E-03 0,01199428 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 23 17 0,000 7,243E-03 0,01198884 ! positive regulation of smooth muscle cell proliferation GO:0048661 20 17 0,000 7,243E-03 0,0119834 ! negative regulation of defense response GO:0031348 19 17 0,000 7,243E-03 0,01197797 ! lipid localization GO:0010876 19 17 0,000 7,243E-03 0,01197254 GO:0019915|lipid storage, ! tube lumen formation GO:0035148 20 17 0,000 7,243E-03 0,01196712 ! negative regulation of cytokine biosynthetic process GO:0042036 18 17 0,000 7,243E-03 0,0119617 ! regulation of systemic arterial blood pressure by hormone GO:0001990 17 17 0,000 7,243E-03 0,01195629 GO:0050886|endocrine process, ! MAP kinase kinase kinase activity GO:0004709 19 17 0,000 7,243E-03 0,01195088 ! negative regulation of protein amino acid phosphorylation GO:0001933 19 17 0,000 7,243E-03 0,01194548 ! protein phosphatase type 2A complex GO:0000159 21 17 0,000 7,243E-03 0,01194008 ! polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 22 17 0,000 7,243E-03 0,01193469 ! response to hexose stimulus GO:0009746 20 17 0,000 7,243E-03 0,0119293 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! transmembrane receptor protein phosphatase activity GO:0019198 24 17 0,000 7,243E-03 0,01192392 GO:0005001|transmembrane receptor protein tyrosine phosphatase activity, ! positive regulation of nitric oxide biosynthetic process GO:0045429 18 17 0,000 7,243E-03 0,01191854 ! AMP binding GO:0016208 19 17 0,000 7,243E-03 0,01191317 ! UDP-galactosyltransferase activity GO:0035250 19 17 0,000 7,243E-03 0,0119078 ! receptor metabolic process GO:0043112 20 17 0,000 7,243E-03 0,01190243 ! neurotransmitter metabolic process GO:0042133 20 17 0,000 7,243E-03 0,01189708 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 23 17 0,000 7,243E-03 0,01189172 ! alcohol binding GO:0043178 20 17 0,000 7,243E-03 0,01188637 ! T cell differentiation in the thymus GO:0033077 28 17 0,000 7,243E-03 0,01188103 ! visual learning GO:0008542 31 17 0,000 7,243E-03 0,01187569 ! structural constituent of eye lens GO:0005212 20 17 0,000 7,243E-03 0,01187035 ! cellular amino acid derivative catabolic process GO:0042219 19 17 0,000 7,243E-03 0,01186502 ! neutrophil chemotaxis GO:0030593 17 17 0,000 7,243E-03 0,0118597 ! protein localization in mitochondrion GO:0070585 19 17 0,000 7,243E-03 0,01185438 GO:0006626|protein targeting to mitochondrion, ! aspartic-type endopeptidase activity GO:0004190 18 17 0,000 7,243E-03 0,01184906 GO:0070001|aspartic-type peptidase activity, ! neutral amino acid transmembrane transporter activity GO:0015175 19 17 0,000 7,243E-03 0,01184375 ! proton-transporting ATP synthase complex GO:0045259 17 17 0,000 7,243E-03 0,01183844 ! translation elongation factor activity GO:0003746 19 17 0,000 7,243E-03 0,01183314 ! histone binding GO:0042393 26 17 0,000 7,243E-03 0,01182784 ! cilium assembly GO:0042384 18 17 0,000 7,243E-03 0,01182255 ! transforming growth factor beta receptor binding GO:0005160 19 17 0,000 7,243E-03 0,01181727 ! positive regulation of homeostatic process GO:0032846 23 17 0,000 7,243E-03 0,01181198 ! solute:hydrogen antiporter activity GO:0015299 18 17 0,000 7,243E-03 0,0118067 ! protein secretion GO:0009306 19 18 0,000 7,668E-03 0,0124933 ! positive regulation of ossification GO:0045778 19 18 0,000 7,668E-03 0,01248772 ! positive regulation of angiogenesis GO:0045766 19 18 0,000 7,668E-03 0,01248215 ! organellar small ribosomal subunit GO:0000314 18 18 0,000 7,668E-03 0,01247658 GO:0005763|mitochondrial small ribosomal subunit, ! protein amino acid deacetylation GO:0006476 19 18 0,000 7,668E-03 0,01247102 ! protein amino acid acetylation GO:0006473 21 18 0,000 7,668E-03 0,01246546 ! positive regulation of nucleocytoplasmic transport GO:0046824 20 18 0,000 7,668E-03 0,01245991 ! cAMP metabolic process GO:0046058 18 18 0,000 7,668E-03 0,01245436 ! regulation of muscle cell differentiation GO:0051147 21 18 0,000 7,668E-03 0,01244882 ! cornified envelope GO:0001533 22 18 0,000 7,668E-03 0,01244328 ! retinoid metabolic process GO:0001523 19 18 0,000 7,668E-03 0,01243775 GO:0016101|diterpenoid metabolic process, ! actomyosin GO:0042641 21 18 0,000 7,668E-03 0,01243222 ! positive regulation of proteolysis GO:0045862 20 18 0,000 7,668E-03 0,0124267 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628 21 18 0,000 7,668E-03 0,01242118 ! calcium-dependent protein binding GO:0048306 20 18 0,000 7,668E-03 0,01241567 ! proton-transporting ATPase activity, rotational mechanism GO:0046961 18 18 0,000 7,668E-03 0,01241016 ! proton-transporting V-type ATPase complex GO:0033176 18 18 0,000 7,668E-03 0,01240465 ! pyrimidine ribonucleoside metabolic process GO:0046131 23 18 0,000 7,668E-03 0,01239916 ! regulation of ion transmembrane transporter activity GO:0032412 21 18 0,000 7,668E-03 0,01239366 ! positive regulation of carbohydrate metabolic process GO:0045913 19 18 0,000 7,668E-03 0,01238817 ! primary neural tube formation GO:0014020 21 18 0,000 7,668E-03 0,01238269 ! recycling endosome GO:0055037 22 18 0,000 7,668E-03 0,01237721 ! muscle cell development GO:0055001 20 18 0,000 7,668E-03 0,01237174 ! kinase activator activity GO:0019209 22 18 0,000 7,668E-03 0,01236627 ! positive regulation of T cell differentiation GO:0045582 28 18 0,000 7,668E-03 0,0123608 ! cerebellum development GO:0021549 20 18 0,000 7,668E-03 0,01235534 ! positive regulation of multicellular organism growth GO:0040018 19 18 0,000 7,668E-03 0,01234989 ! somitogenesis GO:0001756 20 18 0,000 7,668E-03 0,01234444 ! transcription factor TFIID complex GO:0005669 19 18 0,000 7,668E-03 0,01233899 ! low-density lipoprotein binding GO:0030169 19 18 0,000 7,668E-03 0,01233355 ! positive regulation of cytokine secretion GO:0050715 21 18 0,000 7,668E-03 0,01232812 ! negative regulation of intracellular transport GO:0032387 20 18 0,000 7,668E-03 0,01232268 ! glutamine family amino acid catabolic process GO:0009065 21 18 0,000 7,668E-03 0,01231726 ! basal plasma membrane GO:0009925 21 18 0,000 7,668E-03 0,01231184 GO:0045178|basal part of cell, ! vitamin D receptor binding GO:0042809 20 18 0,000 7,668E-03 0,01230642 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters GO:0016894 19 18 0,000 7,668E-03 0,01230101 ! embryonic organ morphogenesis GO:0048562 22 18 0,000 7,668E-03 0,0122956 ! regulation of cell killing GO:0031341 24 18 0,000 7,668E-03 0,0122902 ! positive regulation of cellular catabolic process GO:0031331 20 18 0,000 7,668E-03 0,0122848 ! nuclear chromosome, telomeric region GO:0000784 30 18 0,000 7,668E-03 0,01227941 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 19 18 0,000 7,668E-03 0,01227402 ! intra-Golgi vesicle-mediated transport GO:0006891 20 18 0,000 7,668E-03 0,01226864 ! protein complex scaffold GO:0032947 22 18 0,000 7,668E-03 0,01226326 ! SNAP receptor activity GO:0005484 21 18 0,000 7,668E-03 0,01225789 ! dendrite development GO:0016358 22 18 0,000 7,668E-03 0,01225252 ! cell differentiation in spinal cord GO:0021515 21 18 0,000 7,668E-03 0,01224715 ! inactivation of MAPK activity GO:0000188 20 18 0,000 7,668E-03 0,01224179 ! calmodulin-dependent protein kinase activity GO:0004683 20 18 0,000 7,668E-03 0,01223644 ! D-ribose metabolic process GO:0006014 19 18 0,000 7,668E-03 0,01223109 ! nuclear ubiquitin ligase complex GO:0000152 31 18 0,000 7,668E-03 0,01222574 ! glucuronosyltransferase activity GO:0015020 18 18 0,000 7,668E-03 0,0122204 ! coreceptor activity GO:0015026 28 18 0,000 7,668E-03 0,01221506 ! response to fungus GO:0009620 18 18 0,000 7,668E-03 0,01220973 ! stem cell differentiation GO:0048863 18 18 0,000 7,668E-03 0,0122044 ! intermediate filament-based process GO:0045103 18 18 0,000 7,668E-03 0,01219908 ! heart process GO:0003015 19 18 0,000 7,668E-03 0,01219376 GO:0060047|heart contraction, ! mismatch repair GO:0006298 28 18 0,000 7,668E-03 0,01218845 ! vasodilation GO:0042311 20 18 0,000 7,668E-03 0,01218314 ! transport vesicle membrane GO:0030658 23 18 0,000 7,668E-03 0,01217784 ! MHC protein binding GO:0042287 30 18 0,000 7,668E-03 0,01217254 ! inward rectifier potassium channel activity GO:0005242 22 18 0,000 7,668E-03 0,01216724 ! chloride transmembrane transporter activity GO:0015108 19 18 0,000 7,668E-03 0,01216195 ! bicarbonate transmembrane transporter activity GO:0015106 18 18 0,000 7,668E-03 0,01215667 ! ionotropic glutamate receptor activity GO:0004970 22 18 0,000 7,668E-03 0,01215139 ! cell-cell adherens junction GO:0005913 20 18 0,000 7,668E-03 0,01214611 ! negative regulation of leukocyte proliferation GO:0070664 20 18 0,000 7,668E-03 0,01214084 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! ubiquitin-specific protease activity GO:0004843 19 18 0,000 7,668E-03 0,01213557 ! ATP-dependent RNA helicase activity GO:0004004 28 18 0,000 7,668E-03 0,01213031 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 24 19 0,000 8,092E-03 0,01279627 ! pteridine and derivative metabolic process GO:0042558 29 19 0,000 8,092E-03 0,01279073 ! proteasome core complex GO:0005839 20 19 0,000 8,092E-03 0,01278519 ! hydrolase activity, hydrolyzing N-glycosyl compounds GO:0016799 22 19 0,000 8,092E-03 0,01277966 ! anion:anion antiporter activity GO:0015301 19 19 0,000 8,092E-03 0,01277413 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 24 19 0,000 8,092E-03 0,0127686 ! regulation of transmembrane transporter activity GO:0022898 22 19 0,000 8,092E-03 0,01276308 GO:0032409|regulation of transporter activity, ! regulation of survival gene product expression GO:0045884 23 19 0,000 8,092E-03 0,01275756 ! activation of pro-apoptotic gene products GO:0008633 26 19 0,000 8,092E-03 0,01275205 ! deoxyribonucleotide metabolic process GO:0009262 20 19 0,000 8,092E-03 0,01274655 ! lysosome organization GO:0007040 20 19 0,000 8,092E-03 0,01274105 ! cellular macromolecular complex disassembly GO:0034623 23 19 0,000 8,092E-03 0,01273555 ! central nervous system neuron development GO:0021954 21 19 0,000 8,092E-03 0,01273006 ! threonine-type endopeptidase activity GO:0004298 20 19 0,000 8,092E-03 0,01272457 GO:0070003|threonine-type peptidase activity, ! chromosome condensation GO:0030261 20 19 0,000 8,092E-03 0,01271909 ! peptidyl-serine phosphorylation GO:0018105 26 19 0,000 8,092E-03 0,01271361 ! regulation of endothelial cell migration GO:0010594 22 19 0,000 8,092E-03 0,01270814 ! fatty acid beta-oxidation GO:0006635 21 19 0,000 8,092E-03 0,01270267 ! peptide cross-linking GO:0018149 23 19 0,000 8,092E-03 0,01269721 ! ventricular cardiac muscle morphogenesis GO:0055010 21 19 0,000 8,092E-03 0,01269175 ! beta-catenin binding GO:0008013 23 19 0,000 8,092E-03 0,01268629 ! positive regulation of locomotion GO:0040017 21 19 0,000 8,092E-03 0,01268084 GO:0050921|positive regulation of chemotaxis, ! cell projection membrane GO:0031253 21 19 0,000 8,092E-03 0,0126754 ! positive regulation of inflammatory response GO:0050729 19 19 0,000 8,092E-03 0,01266996 ! trans-Golgi network transport vesicle GO:0030140 26 19 0,000 8,092E-03 0,01266452 ! sphingolipid biosynthetic process GO:0030148 20 19 0,000 8,092E-03 0,01265909 ! vitamin transport GO:0051180 21 19 0,000 8,092E-03 0,01265367 ! positive regulation of osteoblast differentiation GO:0045669 22 19 0,000 8,092E-03 0,01264825 ! terpenoid metabolic process GO:0006721 20 19 0,000 8,092E-03 0,01264283 ! leukotriene biosynthetic process GO:0019370 20 19 0,000 8,092E-03 0,01263742 GO:0043450|alkene biosynthetic process, ! nerve development GO:0021675 24 19 0,000 8,092E-03 0,01263201 ! retinoid binding GO:0005501 19 19 0,000 8,092E-03 0,01262661 GO:0019840|isoprenoid binding, ! regulation of amine transport GO:0051952 23 19 0,000 8,092E-03 0,01262121 ! inositol or phosphatidylinositol phosphatase activity GO:0004437 22 19 0,000 8,092E-03 0,01261581 ! histone deacetylase activity GO:0004407 20 19 0,000 8,092E-03 0,01261042 GO:0033558|protein deacetylase activity, ! positive regulation of fibroblast proliferation GO:0048146 25 19 0,000 8,092E-03 0,01260504 ! gluconeogenesis GO:0006094 23 19 0,000 8,092E-03 0,01259966 ! post-Golgi vesicle-mediated transport GO:0006892 23 19 0,000 8,092E-03 0,01259428 ! microtubule-based transport GO:0010970 20 19 0,000 8,092E-03 0,01258891 ! superoxide metabolic process GO:0006801 21 19 0,000 8,092E-03 0,01258355 ! C21-steroid hormone metabolic process GO:0008207 20 19 0,000 8,092E-03 0,01257819 ! protein amino acid alkylation GO:0008213 22 19 0,000 8,092E-03 0,01257283 GO:0006479|protein amino acid methylation, ! L-ascorbic acid binding GO:0031418 19 19 0,000 8,092E-03 0,01256748 ! regulation of DNA recombination GO:0000018 38 19 0,000 8,092E-03 0,01256213 ! photoreceptor cell maintenance GO:0045494 23 19 0,000 8,092E-03 0,01255679 ! positive regulation of cytoskeleton organization GO:0051495 22 19 0,000 8,092E-03 0,01255145 ! acetylcholine binding GO:0042166 20 19 0,000 8,092E-03 0,01254611 ! heme metabolic process GO:0042168 20 19 0,000 8,092E-03 0,01254078 ! SH2 domain binding GO:0042169 25 19 0,000 8,092E-03 0,01253546 ! neurotransmitter:sodium symporter activity GO:0005328 21 19 0,000 8,092E-03 0,01253014 ! negative regulation of protein catabolic process GO:0042177 19 19 0,000 8,092E-03 0,01252482 ! carbohydrate kinase activity GO:0019200 20 19 0,000 8,092E-03 0,01251951 ! RNA methyltransferase activity GO:0008173 19 19 0,000 8,092E-03 0,0125142 ! RNA-dependent ATPase activity GO:0008186 29 19 0,000 8,092E-03 0,0125089 ! body fluid secretion GO:0007589 21 19 0,000 8,092E-03 0,0125036 ! neuropeptide hormone activity GO:0005184 25 19 0,000 8,092E-03 0,01249831 ! secretory granule membrane GO:0030667 21 19 0,000 8,092E-03 0,01249302 ! extracellular-glutamate-gated ion channel activity GO:0005234 23 19 0,000 8,092E-03 0,01248773 ! ribonucleoprotein binding GO:0043021 20 19 0,000 8,092E-03 0,01248245 ! peptidase activator activity GO:0016504 21 19 0,000 8,092E-03 0,01247718 ! transcription elongation regulator activity GO:0003711 20 19 0,000 8,092E-03 0,01247191 ! small conjugating protein-specific protease activity GO:0019783 21 19 0,000 8,092E-03 0,01246664 ! regulation of BMP signaling pathway GO:0030510 20 19 0,000 8,092E-03 0,01246138 ! sialyltransferase activity GO:0008373 31 19 0,000 8,092E-03 0,01245612 ! ATP-dependent DNA helicase activity GO:0004003 30 19 0,000 8,092E-03 0,01245087 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 23 20 0,000 8,517E-03 0,0130982 ! regulation of anti-apoptosis GO:0045767 20 20 0,000 8,517E-03 0,01309268 ! reciprocal meiotic recombination GO:0007131 40 20 0,000 8,517E-03 0,01308717 ! protein amino acid ADP-ribosylation GO:0006471 23 20 0,000 8,517E-03 0,01308166 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016796 30 20 0,000 8,517E-03 0,01307615 ! retina development in camera-type eye GO:0060041 24 20 0,000 8,517E-03 0,01307065 ! negative regulation of lipid metabolic process GO:0045833 34 20 0,000 8,517E-03 0,01306515 ! ovarian follicle development GO:0001541 21 20 0,000 8,517E-03 0,01305966 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 33 20 0,000 8,517E-03 0,01305417 ! proton-transporting two-sector ATPase complex, proton-transporting domain GO:0033177 21 20 0,000 8,517E-03 0,01304869 ! hydrogen peroxide metabolic process GO:0042743 20 20 0,000 8,517E-03 0,01304321 ! diencephalon development GO:0021536 22 20 0,000 8,517E-03 0,01303774 ! nuclear inner membrane GO:0005637 21 20 0,000 8,517E-03 0,01303227 ! regulation of lipid transport GO:0032368 22 20 0,000 8,517E-03 0,01302681 ! response to glucocorticoid stimulus GO:0051384 22 20 0,000 8,517E-03 0,01302135 ! glutathione metabolic process GO:0006749 21 20 0,000 8,517E-03 0,01301589 ! transcriptional repressor complex GO:0017053 23 20 0,000 8,517E-03 0,01301044 ! vitamin A metabolic process GO:0006776 20 20 0,000 8,517E-03 0,013005 ! positive regulation of lymphocyte differentiation GO:0045621 30 20 0,000 8,517E-03 0,01299955 ! negative regulation of cytokine production GO:0001818 23 20 0,000 8,517E-03 0,01299412 ! phosphorus-oxygen lyase activity GO:0016849 21 20 0,000 8,517E-03 0,01298868 ! peptide hormone secretion GO:0030072 25 20 0,000 8,517E-03 0,01298326 GO:0002790|peptide secretion, ! actin filament-based movement GO:0030048 22 20 0,000 8,517E-03 0,01297783 ! Rab GTPase binding GO:0017137 22 20 0,000 8,517E-03 0,01297241 ! initiation of viral infection GO:0019059 22 20 0,000 8,517E-03 0,012967 ! voltage-gated anion channel activity GO:0008308 23 20 0,000 8,517E-03 0,01296159 ! heterochromatin GO:0000792 20 20 0,000 8,517E-03 0,01295619 ! aminoglycan catabolic process GO:0006026 22 20 0,000 8,517E-03 0,01295079 ! glycosaminoglycan biosynthetic process GO:0006024 21 20 0,000 8,517E-03 0,01294539 ! regulation of chemotaxis GO:0050920 22 20 0,000 8,517E-03 0,01294 ! calcium-independent cell-cell adhesion GO:0016338 27 20 0,000 8,517E-03 0,01293461 ! high-density lipoprotein particle GO:0034364 30 20 0,000 8,517E-03 0,01292923 ! visual behavior GO:0007632 34 20 0,000 8,517E-03 0,01292385 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 23 20 0,000 8,517E-03 0,01291848 ! immune response-activating cell surface receptor signaling pathway GO:0002429 27 20 0,000 8,517E-03 0,01291311 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of nitric oxide biosynthetic process GO:0045428 21 20 0,000 8,517E-03 0,01290774 ! vesicle docking during exocytosis GO:0006904 21 20 0,000 8,517E-03 0,01290238 ! cell structure disassembly during apoptosis GO:0006921 31 20 0,000 8,517E-03 0,01289703 ! nucleotide kinase activity GO:0019201 26 20 0,000 8,517E-03 0,01289167 ! rRNA binding GO:0019843 22 20 0,000 8,517E-03 0,01288633 ! cytolysis GO:0019835 22 20 0,000 8,517E-03 0,01288098 ! renal system process GO:0003014 22 20 0,000 8,517E-03 0,01287565 ! specific transcriptional repressor activity GO:0016566 23 20 0,000 8,517E-03 0,01287031 ! fatty acid transport GO:0015908 23 20 0,000 8,517E-03 0,01286498 ! transaminase activity GO:0008483 22 20 0,000 8,517E-03 0,01285966 ! activation of JUN kinase activity GO:0007257 22 20 0,000 8,517E-03 0,01285434 ! collagen catabolic process GO:0030574 21 20 0,000 8,517E-03 0,01284902 ! microvillus GO:0005902 25 20 0,000 8,517E-03 0,01284371 ! tumor necrosis factor receptor binding GO:0005164 22 20 0,000 8,517E-03 0,0128384 ! connexon complex GO:0005922 23 20 0,000 8,517E-03 0,0128331 ! positive regulation of DNA replication GO:0045740 27 21 0,000 8,941E-03 0,01346667 ! positive regulation of protein catabolic process GO:0045732 23 21 0,000 8,941E-03 0,01346112 ! translational initiation GO:0006413 21 21 0,000 8,941E-03 0,01345556 ! NF-kappaB binding GO:0051059 31 21 0,000 8,941E-03 0,01345001 ! heterotrimeric G-protein complex GO:0005834 23 21 0,000 8,941E-03 0,01344447 ! positive regulation of bone remodeling GO:0046852 22 21 0,000 8,941E-03 0,01343893 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 25 21 0,000 8,941E-03 0,0134334 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! transition metal ion transmembrane transporter activity GO:0046915 25 21 0,000 8,941E-03 0,01342786 ! glutathione transferase activity GO:0004364 21 21 0,000 8,941E-03 0,01342234 ! voltage-gated calcium channel complex GO:0005891 28 21 0,000 8,941E-03 0,01341682 ! glutamate signaling pathway GO:0007215 23 21 0,000 8,941E-03 0,0134113 ! regeneration GO:0031099 24 21 0,000 8,941E-03 0,01340579 ! MHC class I protein complex GO:0042612 31 21 0,000 8,941E-03 0,01340028 ! cellular response to starvation GO:0009267 22 21 0,000 8,941E-03 0,01339478 ! peroxisome organization GO:0007031 22 21 0,000 8,941E-03 0,01338928 ! vacuole organization GO:0007033 23 21 0,000 8,941E-03 0,01338378 ! apoptotic nuclear changes GO:0030262 24 21 0,000 8,941E-03 0,0133783 ! response to lipopolysaccharide GO:0032496 31 21 0,000 8,941E-03 0,01337281 ! neural crest cell development GO:0014032 24 21 0,000 8,941E-03 0,01336733 GO:0014033|neural crest cell differentiation, ! regulation of protein binding GO:0043393 25 21 0,000 8,941E-03 0,01336185 ! nucleobase metabolic process GO:0009112 23 21 0,000 8,941E-03 0,01335638 ! regulation of steroid metabolic process GO:0019218 23 21 0,000 8,941E-03 0,01335091 ! ribonucleoside monophosphate metabolic process GO:0009161 26 21 0,000 8,941E-03 0,01334545 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! monocarboxylic acid transmembrane transporter activity GO:0008028 25 21 0,000 8,941E-03 0,01333999 ! pallium development GO:0021543 22 21 0,000 8,941E-03 0,01333454 ! synaptic vesicle transport GO:0048489 25 21 0,000 8,941E-03 0,01332909 ! negative regulation of Wnt receptor signaling pathway GO:0030178 22 21 0,000 8,941E-03 0,01332365 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 21 21 0,000 8,941E-03 0,0133182 ! leukocyte homeostasis GO:0001776 22 21 0,000 8,941E-03 0,01331277 ! negative regulation of neuron differentiation GO:0045665 22 21 0,000 8,941E-03 0,01330734 ! cyclase activity GO:0009975 22 21 0,000 8,941E-03 0,01330191 ! aspartate family amino acid metabolic process GO:0009066 24 21 0,000 8,941E-03 0,01329649 ! gut development GO:0048565 23 21 0,000 8,941E-03 0,01329107 ! calcium-dependent phospholipid binding GO:0005544 22 21 0,000 8,941E-03 0,01328566 ! negative regulation of T cell activation GO:0050868 23 21 0,000 8,941E-03 0,01328025 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 8,941E-03 0,01327484 ! cortical actin cytoskeleton GO:0030864 21 21 0,000 8,941E-03 0,01326944 ! cellular aldehyde metabolic process GO:0006081 22 21 0,000 8,941E-03 0,01326404 ! membrane lipid biosynthetic process GO:0046467 22 21 0,000 8,941E-03 0,01325865 ! nucleotide-excision repair, DNA damage removal GO:0000718 22 21 0,000 8,941E-03 0,01325326 ! axis specification GO:0009798 25 21 0,000 8,941E-03 0,01324788 ! response to alkaloid GO:0043279 27 21 0,000 8,941E-03 0,0132425 ! 4 iron, 4 sulfur cluster binding GO:0051539 24 21 0,000 8,941E-03 0,01323713 ! response to ethanol GO:0045471 28 21 0,000 8,941E-03 0,01323176 ! response to carbohydrate stimulus GO:0009743 24 21 0,000 8,941E-03 0,01322639 ! smooth muscle contraction GO:0006939 25 21 0,000 8,941E-03 0,01322103 ! ubiquitin binding GO:0043130 25 21 0,000 8,941E-03 0,01321567 ! vesicle targeting GO:0006903 22 21 0,000 8,941E-03 0,01321032 ! phospholipase A2 activity GO:0004623 32 21 0,000 8,941E-03 0,01320497 ! SNARE binding GO:0000149 24 21 0,000 8,941E-03 0,01319963 ! interaction with host GO:0051701 26 21 0,000 8,941E-03 0,01319429 ! positive regulation of myeloid leukocyte differentiation GO:0002763 26 21 0,000 8,941E-03 0,01318895 ! lymphocyte proliferation GO:0046651 24 21 0,000 8,941E-03 0,01318362 ! regulation of tumor necrosis factor production GO:0032680 24 21 0,000 8,941E-03 0,0131783 ! regulation of interleukin-2 production GO:0032663 21 21 0,000 8,941E-03 0,01317297 ! negative regulation of angiogenesis GO:0016525 23 21 0,000 8,941E-03 0,01316766 ! cell-cell junction organization GO:0045216 24 21 0,000 8,941E-03 0,01316234 ! single-stranded RNA binding GO:0003727 22 21 0,000 8,941E-03 0,01315703 ! cyclic nucleotide binding GO:0030551 25 21 0,000 8,941E-03 0,01315173 ! caveola GO:0005901 25 21 0,000 8,941E-03 0,01314643 ! water-soluble vitamin biosynthetic process GO:0042364 23 21 0,000 8,941E-03 0,01314113 ! insulin receptor binding GO:0005158 25 21 0,000 8,941E-03 0,01313584 ! pyrimidine nucleotide biosynthetic process GO:0006221 26 21 0,000 8,941E-03 0,01313055 ! regulation of multi-organism process GO:0043900 32 21 0,000 8,941E-03 0,01312527 ! mRNA export from nucleus GO:0006406 26 22 0,000 9,365E-03 0,01374218 ! metencephalon development GO:0022037 25 22 0,000 9,365E-03 0,01373665 ! regulation of interferon-gamma production GO:0032649 25 22 0,000 9,365E-03 0,01373113 ! hormone secretion GO:0046879 28 22 0,000 9,365E-03 0,01372561 ! vesicle docking GO:0048278 24 22 0,000 9,365E-03 0,0137201 ! muscle myosin complex GO:0005859 23 22 0,000 9,365E-03 0,01371459 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 24 22 0,000 9,365E-03 0,01370909 ! actomyosin structure organization GO:0031032 24 22 0,000 9,365E-03 0,01370359 ! microtubule organizing center organization GO:0031023 33 22 0,000 9,365E-03 0,0136981 GO:0051297|centrosome organization, ! positive regulation of innate immune response GO:0045089 23 22 0,000 9,365E-03 0,01369261 ! sperm motility GO:0030317 23 22 0,000 9,365E-03 0,01368712 ! potassium channel regulator activity GO:0015459 29 22 0,000 9,365E-03 0,01368164 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 24 22 0,000 9,365E-03 0,01367616 ! vacuolar transport GO:0007034 22 22 0,000 9,365E-03 0,01367069 ! oxidoreductase activity, acting on heme group of donors GO:0016675 23 22 0,000 9,365E-03 0,01366522 GO:0016676|oxidoreductase activity, acting on heme group of donors, oxygen as acceptor, GO:0004129|cytochrome-c oxidase activity, GO:0015002|heme-copper terminal oxidase activity, ! central nervous system neuron differentiation GO:0021953 24 22 0,000 9,365E-03 0,01365976 ! cellular response to reactive oxygen species GO:0034614 26 22 0,000 9,365E-03 0,0136543 ! purine ribonucleoside metabolic process GO:0046128 24 22 0,000 9,365E-03 0,01364884 GO:0042278|purine nucleoside metabolic process, ! G-protein chemoattractant receptor activity GO:0001637 24 22 0,000 9,365E-03 0,01364339 GO:0004950|chemokine receptor activity, ! response to corticosteroid stimulus GO:0031960 25 22 0,000 9,365E-03 0,01363795 ! PML body GO:0016605 25 22 0,000 9,365E-03 0,0136325 ! barbed-end actin filament capping GO:0051016 24 22 0,000 9,365E-03 0,01362707 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 27 22 0,000 9,365E-03 0,01362163 ! regulation of foam cell differentiation GO:0010743 28 22 0,000 9,365E-03 0,0136162 ! cyclic nucleotide biosynthetic process GO:0009190 23 22 0,000 9,365E-03 0,01361078 ! leukotriene metabolic process GO:0006691 23 22 0,000 9,365E-03 0,01360536 ! glycosphingolipid metabolic process GO:0006687 23 22 0,000 9,365E-03 0,01359994 ! deacetylase activity GO:0019213 23 22 0,000 9,365E-03 0,01359453 ! pentose metabolic process GO:0019321 23 22 0,000 9,365E-03 0,01358912 ! collagen fibril organization GO:0030199 32 22 0,000 9,365E-03 0,01358372 ! regulation of response to biotic stimulus GO:0002831 33 22 0,000 9,365E-03 0,01357832 ! positive regulation of adaptive immune response GO:0002821 22 22 0,000 9,365E-03 0,01357293 ! peptidyl-serine modification GO:0018209 30 22 0,000 9,365E-03 0,01356754 ! DNA-directed RNA polymerase complex GO:0000428 23 22 0,000 9,365E-03 0,01356215 GO:0055029|nuclear DNA-directed RNA polymerase complex, ! positive regulation of B cell activation GO:0050871 26 22 0,000 9,365E-03 0,01355677 ! endoribonuclease activity, producing 5'-phosphomonoesters GO:0016891 32 22 0,000 9,365E-03 0,01355139 ! positive regulation of behavior GO:0048520 24 22 0,000 9,365E-03 0,01354602 ! regulation of generation of precursor metabolites and energy GO:0043467 25 22 0,000 9,365E-03 0,01354065 ! aromatic compound catabolic process GO:0019439 23 22 0,000 9,365E-03 0,01353528 ! embryonic epithelial tube formation GO:0001838 25 22 0,000 9,365E-03 0,01352992 GO:0001841|neural tube formation, ! telomere organization GO:0032200 43 22 0,000 9,365E-03 0,01352457 GO:0000723|telomere maintenance, ! acetyl-CoA catabolic process GO:0046356 24 22 0,000 9,365E-03 0,01351921 GO:0006099|tricarboxylic acid cycle, ! protein tetramerization GO:0051262 25 22 0,000 9,365E-03 0,01351387 ! DNA catabolic process, endonucleolytic GO:0000737 24 22 0,000 9,365E-03 0,01350852 ! glycerol metabolic process GO:0006071 24 22 0,000 9,365E-03 0,01350318 ! cellular component assembly involved in morphogenesis GO:0010927 23 22 0,000 9,365E-03 0,01349785 ! nuclear chromatin GO:0000790 23 22 0,000 9,365E-03 0,01349252 ! cellular iron ion homeostasis GO:0006879 25 22 0,000 9,365E-03 0,01348719 ! aminoglycan biosynthetic process GO:0006023 23 22 0,000 9,365E-03 0,01348187 ! positive regulation of JAK-STAT cascade GO:0046427 25 22 0,000 9,365E-03 0,01347655 ! sterol binding GO:0032934 24 22 0,000 9,365E-03 0,01347124 ! calcium-dependent cell-cell adhesion GO:0016339 23 22 0,000 9,365E-03 0,01346593 ! digestive system process GO:0022600 25 22 0,000 9,365E-03 0,01346062 ! neurotransmitter transporter activity GO:0005326 24 22 0,000 9,365E-03 0,01345532 ! organic acid:sodium symporter activity GO:0005343 25 22 0,000 9,365E-03 0,01345002 ! nonmotile primary cilium GO:0031513 24 22 0,000 9,365E-03 0,01344473 ! negative regulation of myeloid leukocyte differentiation GO:0002762 26 22 0,000 9,365E-03 0,01343944 ! base-excision repair GO:0006284 33 22 0,000 9,365E-03 0,01343415 ! regulation of chromosome organization GO:0033044 27 22 0,000 9,365E-03 0,01342887 ! DNA modification GO:0006304 25 22 0,000 9,365E-03 0,0134236 ! detection of chemical stimulus GO:0009593 23 22 0,000 9,365E-03 0,01341832 ! positive regulation of tissue remodeling GO:0034105 23 22 0,000 9,365E-03 0,01341306 ! GABA-A receptor activity GO:0004890 27 22 0,000 9,365E-03 0,01340779 ! response to cytokine stimulus GO:0034097 25 22 0,000 9,365E-03 0,01340253 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0033764 24 22 0,000 9,365E-03 0,01339728 ! pyrimidine nucleoside metabolic process GO:0006213 27 22 0,000 9,365E-03 0,01339202 ! phosphoprotein phosphatase inhibitor activity GO:0004864 25 22 0,000 9,365E-03 0,01338678 ! solute:cation antiporter activity GO:0015298 23 22 0,000 9,365E-03 0,01338153 ! regulation of transmembrane transport GO:0034762 28 23 0,000 9,789E-03 0,01398169 ! protein amino acid O-linked glycosylation GO:0006493 28 23 0,000 9,789E-03 0,01397622 ! leukocyte adhesion GO:0007159 26 23 0,000 9,789E-03 0,01397075 ! dicarboxylic acid metabolic process GO:0043648 27 23 0,000 9,789E-03 0,01396529 ! odontogenesis of dentine-containing tooth GO:0042475 26 23 0,000 9,789E-03 0,01395983 ! positive regulation of endocytosis GO:0045807 25 23 0,000 9,789E-03 0,01395438 ! mitochondrial membrane organization GO:0007006 25 23 0,000 9,789E-03 0,01394892 ! ureteric bud development GO:0001657 24 23 0,000 9,789E-03 0,01394348 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 27 23 0,000 9,789E-03 0,01393804 ! regulation of insulin secretion GO:0050796 27 23 0,000 9,789E-03 0,0139326 ! vitamin biosynthetic process GO:0009110 25 23 0,000 9,789E-03 0,01392716 ! negative regulation of neurogenesis GO:0050768 29 23 0,000 9,789E-03 0,01392173 ! cholesterol biosynthetic process GO:0006695 29 23 0,000 9,789E-03 0,01391631 ! deaminase activity GO:0019239 24 23 0,000 9,789E-03 0,01391089 ! sensory perception of pain GO:0019233 26 23 0,000 9,789E-03 0,01390547 ! lipid kinase activity GO:0001727 26 23 0,000 9,789E-03 0,01390006 ! platelet activation GO:0030168 27 23 0,000 9,789E-03 0,01389465 ! proteoglycan biosynthetic process GO:0030166 24 23 0,000 9,789E-03 0,01388924 ! positive regulation of intracellular transport GO:0032388 26 23 0,000 9,789E-03 0,01388384 ! regulation of blood coagulation GO:0030193 26 23 0,000 9,789E-03 0,01387845 ! regulation of cytokine secretion GO:0050707 27 23 0,000 9,789E-03 0,01387306 ! fat-soluble vitamin metabolic process GO:0006775 23 23 0,000 9,789E-03 0,01386767 ! cellular alkene metabolic process GO:0043449 24 23 0,000 9,789E-03 0,01386229 ! aromatic amino acid family metabolic process GO:0009072 25 23 0,000 9,789E-03 0,01385691 ! cell surface binding GO:0043498 28 23 0,000 9,789E-03 0,01385153 ! porphyrin metabolic process GO:0006778 24 23 0,000 9,789E-03 0,01384616 GO:0033013|tetrapyrrole metabolic process, ! ligase activity, forming carbon-sulfur bonds GO:0016877 24 23 0,000 9,789E-03 0,01384079 ! regulation of glucose import GO:0046324 28 23 0,000 9,789E-03 0,01383543 ! insulin-like growth factor binding GO:0005520 27 23 0,000 9,789E-03 0,01383007 ! alditol metabolic process GO:0019400 25 23 0,000 9,789E-03 0,01382472 ! positive regulation of JUN kinase activity GO:0043507 25 23 0,000 9,789E-03 0,01381937 ! pyruvate metabolic process GO:0006090 27 23 0,000 9,789E-03 0,01381402 ! zinc ion transport GO:0006829 26 23 0,000 9,789E-03 0,01380868 ! N-acetylglucosamine metabolic process GO:0006044 26 23 0,000 9,789E-03 0,01380334 ! antigen processing and presentation of peptide antigen GO:0048002 30 23 0,000 9,789E-03 0,01379801 ! sex determination GO:0007530 25 23 0,000 9,789E-03 0,01379268 ! phosphate binding GO:0042301 25 23 0,000 9,789E-03 0,01378735 ! positive regulation of leukocyte mediated immunity GO:0002705 24 23 0,000 9,789E-03 0,01378203 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of interleukin-6 production GO:0032675 26 23 0,000 9,789E-03 0,01377672 ! nuclear-transcribed mRNA catabolic process GO:0000956 26 23 0,000 9,789E-03 0,0137714 ! 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 28 23 0,000 9,789E-03 0,01376609 ! ubiquitin protein ligase binding GO:0031625 24 23 0,000 9,789E-03 0,01376079 ! positive regulation of nuclear division GO:0051785 35 23 0,000 9,789E-03 0,01375549 GO:0045840|positive regulation of mitosis, ! synaptogenesis GO:0007416 25 23 0,000 9,789E-03 0,01375019 ! regulation of bone mineralization GO:0030500 23 23 0,000 9,789E-03 0,0137449 ! neurotransmitter secretion GO:0007269 26 23 0,000 9,789E-03 0,01373961 ! ethanolamine and derivative metabolic process GO:0042439 34 23 0,000 9,789E-03 0,01373433 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 25 23 0,000 9,789E-03 0,01372905 ! leukocyte proliferation GO:0070661 26 23 0,000 9,789E-03 0,01372377 GO:0032943|mononuclear cell proliferation, ! myosin II complex GO:0016460 24 23 0,000 9,789E-03 0,0137185 ! growth cone GO:0030426 27 24 0,000 0,01021241 0,01430678 ! oligosaccharide metabolic process GO:0009311 29 24 0,000 0,01021241 0,01430129 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0016706 24 24 0,000 0,01021241 0,0142958 ! pancreas development GO:0031016 27 24 0,000 0,01021241 0,01429032 ! androgen receptor binding GO:0050681 34 24 0,000 0,01021241 0,01428484 ! calcium channel complex GO:0034704 31 24 0,000 0,01021241 0,01427936 ! coenzyme catabolic process GO:0009109 26 24 0,000 0,01021241 0,01427389 ! negative regulation of cell development GO:0010721 30 24 0,000 0,01021241 0,01426843 ! cardiac muscle tissue morphogenesis GO:0055008 27 24 0,000 0,01021241 0,01426296 GO:0060415|muscle tissue morphogenesis, ! phosphatase inhibitor activity GO:0019212 27 24 0,000 0,01021241 0,0142575 ! regulation of ARF GTPase activity GO:0032312 28 24 0,000 0,01021241 0,01425205 ! regulation of oxidoreductase activity GO:0051341 24 24 0,000 0,01021241 0,0142466 ! RNA splicing factor activity, transesterification mechanism GO:0031202 25 24 0,000 0,01021241 0,01424115 ! Rho GTPase binding GO:0017048 36 24 0,000 0,01021241 0,01423571 ! regulation of glucose transport GO:0010827 29 24 0,000 0,01021241 0,01423027 ! serine family amino acid metabolic process GO:0009069 27 24 0,000 0,01021241 0,01422484 ! intramolecular transferase activity GO:0016866 26 24 0,000 0,01021241 0,01421941 ! phosphoinositide phospholipase C activity GO:0004435 28 24 0,000 0,01021241 0,01421399 GO:0004434|inositol or phosphatidylinositol phosphodiesterase activity, ! Z disc GO:0030018 27 24 0,000 0,01021241 0,01420857 ! protein stabilization GO:0050821 24 24 0,000 0,01021241 0,01420315 ! protein import into nucleus, translocation GO:0000060 27 24 0,000 0,01021241 0,01419774 ! embryonic pattern specification GO:0009880 29 24 0,000 0,01021241 0,01419233 ! negative regulation of actin filament depolymerization GO:0030835 26 24 0,000 0,01021241 0,01418692 ! RNA polymerase complex GO:0030880 25 24 0,000 0,01021241 0,01418152 ! cellular polysaccharide biosynthetic process GO:0033692 24 24 0,000 0,01021241 0,01417613 ! glucosamine metabolic process GO:0006041 27 24 0,000 0,01021241 0,01417073 ! small conjugating protein binding GO:0032182 29 24 0,000 0,01021241 0,01416535 ! regulation of transcription factor import into nucleus GO:0042990 26 24 0,000 0,01021241 0,01415996 ! chemokine binding GO:0019956 26 24 0,000 0,01021241 0,01415458 ! catechol metabolic process GO:0009712 29 24 0,000 0,01021241 0,01414921 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! regulation of smooth muscle contraction GO:0006940 28 24 0,000 0,01021241 0,01414383 ! NAD+ ADP-ribosyltransferase activity GO:0003950 26 24 0,000 0,01021241 0,01413847 ! multicellular organismal response to stress GO:0033555 27 24 0,000 0,01021241 0,0141331 ! cell aging GO:0007569 47 24 0,000 0,01021241 0,01412774 ! immune response-activating signal transduction GO:0002757 31 24 0,000 0,01021241 0,01412239 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 26 24 0,000 0,01021241 0,01411704 ! fibroblast growth factor receptor signaling pathway GO:0008543 27 24 0,000 0,01021241 0,01411169 ! voltage-gated calcium channel activity GO:0005245 31 24 0,000 0,01021241 0,01410635 ! cyclic-nucleotide phosphodiesterase activity GO:0004112 29 24 0,000 0,01021241 0,01410101 ! metallocarboxypeptidase activity GO:0004181 24 24 0,000 0,01021241 0,01409567 ! caspase regulator activity GO:0043028 26 24 0,000 0,01021241 0,01409034 ! 3'-5' exonuclease activity GO:0008408 43 24 0,000 0,01021241 0,01408501 ! small nuclear ribonucleoprotein complex GO:0030532 24 24 0,000 0,01021241 0,01407969 ! selenium binding GO:0008430 24 24 0,000 0,01021241 0,01407437 ! spindle pole GO:0000922 35 24 0,000 0,01021241 0,01406906 ! Rho GTPase activator activity GO:0005100 28 24 0,000 0,01021241 0,01406374 ! site of polarized growth GO:0030427 28 25 0,000 0,01063594 0,01464147 ! phenol metabolic process GO:0018958 31 25 0,000 0,01063594 0,01463595 ! regulation of lipid biosynthetic process GO:0046890 35 25 0,000 0,01063594 0,01463043 ! protein amino acid acylation GO:0043543 28 25 0,000 0,01063594 0,01462491 ! aromatase activity GO:0070330 28 25 0,000 0,01063594 0,0146194 ! cholesterol homeostasis GO:0042632 27 25 0,000 0,01063594 0,0146139 GO:0055092|sterol homeostasis, ! positive regulation of epithelial cell proliferation GO:0050679 29 25 0,000 0,01063594 0,01460839 ! oxidoreductase activity, acting on the CH-NH group of donors GO:0016645 29 25 0,000 0,01063594 0,0146029 ! response to starvation GO:0042594 26 25 0,000 0,01063594 0,0145974 ! dynein complex GO:0030286 28 25 0,000 0,01063594 0,01459191 ! ARF GTPase activator activity GO:0008060 29 25 0,000 0,01063594 0,01458643 ! regulation of behavior GO:0050795 27 25 0,000 0,01063594 0,01458094 ! regulation of biomineral formation GO:0070167 25 25 0,000 0,01063594 0,01457547 ! hexose biosynthetic process GO:0019319 31 25 0,000 0,01063594 0,01456999 ! group transfer coenzyme metabolic process GO:0006752 25 25 0,000 0,01063594 0,01456452 ! hormone transport GO:0009914 31 25 0,000 0,01063594 0,01455906 ! response to molecule of bacterial origin GO:0002237 35 25 0,000 0,01063594 0,0145536 ! cell adhesion molecule binding GO:0050839 29 25 0,000 0,01063594 0,01454814 ! regulation of coagulation GO:0050818 28 25 0,000 0,01063594 0,01454269 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,01063594 0,01453724 ! myeloid leukocyte differentiation GO:0002573 28 25 0,000 0,01063594 0,0145318 ! acetyl-CoA metabolic process GO:0006084 27 25 0,000 0,01063594 0,01452635 ! chromosome, telomeric region GO:0000781 38 25 0,000 0,01063594 0,01452092 ! molting cycle process GO:0022404 28 25 0,000 0,01063594 0,01451549 GO:0022405|hair cycle process, GO:0001942|hair follicle development, ! collagen metabolic process GO:0032963 26 25 0,000 0,01063594 0,01451006 ! xenobiotic metabolic process GO:0006805 27 25 0,000 0,01063594 0,01450463 ! phototransduction GO:0007602 27 25 0,000 0,01063594 0,01449921 ! negative regulation of response to external stimulus GO:0032102 30 25 0,000 0,01063594 0,0144938 ! regulation of endothelial cell proliferation GO:0001936 29 25 0,000 0,01063594 0,01448838 ! protein phosphatase binding GO:0019903 27 25 0,000 0,01063594 0,01448298 ! negative regulation of DNA replication GO:0008156 31 25 0,000 0,01063594 0,01447757 ! multicellular organismal catabolic process GO:0044243 27 25 0,000 0,01063594 0,01447217 ! autophagy GO:0006914 28 25 0,000 0,01063594 0,01446678 ! steroid dehydrogenase activity GO:0016229 27 25 0,000 0,01063594 0,01446138 ! response to ionizing radiation GO:0010212 37 25 0,000 0,01063594 0,014456 ! DNA-directed DNA polymerase activity GO:0003887 30 25 0,000 0,01063594 0,01445061 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 31 26 0,000 0,01105931 0,01502023 ! epidermal growth factor receptor signaling pathway GO:0007173 32 26 0,000 0,01105931 0,01501464 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 29 26 0,000 0,01105931 0,01500906 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen GO:0016709 28 26 0,000 0,01105931 0,01500348 ! positive regulation of lipid metabolic process GO:0045834 27 26 0,000 0,01105931 0,0149979 ! hair cycle GO:0042633 29 26 0,000 0,01105931 0,01499233 GO:0042303|molting cycle, ! thyroid hormone receptor binding GO:0046966 30 26 0,000 0,01105931 0,01498676 ! polysaccharide catabolic process GO:0000272 39 26 0,000 0,01105931 0,01498119 ! peptidyl-tyrosine phosphorylation GO:0018108 30 26 0,000 0,01105931 0,01497563 ! early endosome membrane GO:0031901 31 26 0,000 0,01105931 0,01497007 ! negative regulation of protein kinase cascade GO:0010741 40 26 0,000 0,01105931 0,01496452 ! iron ion homeostasis GO:0055072 29 26 0,000 0,01105931 0,01495897 ! glycolipid metabolic process GO:0006664 36 26 0,000 0,01105931 0,01495343 ! GABA receptor activity GO:0016917 31 26 0,000 0,01105931 0,01494789 ! PDZ domain binding GO:0030165 28 26 0,000 0,01105931 0,01494235 ! positive regulation of protein secretion GO:0050714 29 26 0,000 0,01105931 0,01493682 ! regulation of cellular carbohydrate metabolic process GO:0010675 29 26 0,000 0,01105931 0,01493129 ! AP-type membrane coat adaptor complex GO:0030119 30 26 0,000 0,01105931 0,01492577 GO:0030131|clathrin adaptor complex, ! neuromuscular process controlling balance GO:0050885 32 26 0,000 0,01105931 0,01492025 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016893 45 26 0,000 0,01105931 0,01491473 ! fatty acid binding GO:0005504 28 26 0,000 0,01105931 0,01490922 ! blastocyst development GO:0001824 27 26 0,000 0,01105931 0,01490371 ! regulation of JUN kinase activity GO:0043506 28 26 0,000 0,01105931 0,01489821 ! lysine N-acetyltransferase activity GO:0004468 29 26 0,000 0,01105931 0,01489271 GO:0004402|histone acetyltransferase activity, ! negative regulation of protein polymerization GO:0032272 37 26 0,000 0,01105931 0,01488721 ! regulation of fibroblast proliferation GO:0048145 32 26 0,000 0,01105931 0,01488172 ! regulation of smooth muscle cell proliferation GO:0048660 30 26 0,000 0,01105931 0,01487624 ! regulation of actin filament depolymerization GO:0030834 28 26 0,000 0,01105931 0,01487075 ! positive regulation of cell projection organization GO:0031346 27 26 0,000 0,01105931 0,01486527 ! iron ion transport GO:0006826 33 26 0,000 0,01105931 0,0148598 ! regulation of synaptic plasticity GO:0048167 36 26 0,000 0,01105931 0,01485433 ! glucose transport GO:0015758 27 26 0,000 0,01105931 0,01484886 ! insulin receptor signaling pathway GO:0008286 34 26 0,000 0,01105931 0,0148434 ! spinal cord development GO:0021510 30 26 0,000 0,01105931 0,01483794 ! histone deacetylase complex GO:0000118 29 26 0,000 0,01105931 0,01483248 ! regulation of peptide secretion GO:0002791 30 26 0,000 0,01105931 0,01482703 ! regulation of production of molecular mediator of immune response GO:0002700 27 26 0,000 0,01105931 0,01482158 ! RNA helicase activity GO:0003724 46 26 0,000 0,01105931 0,01481614 ! brush border GO:0005903 30 26 0,000 0,01105931 0,0148107 ! gap junction GO:0005921 29 26 0,000 0,01105931 0,01480527 ! anion:cation symporter activity GO:0015296 29 26 0,000 0,01105931 0,01479983 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 39 27 0,000 0,01148252 0,01536055 ! mRNA catabolic process GO:0006402 31 27 0,000 0,01148252 0,01535492 ! myelination GO:0042552 31 27 0,000 0,01148252 0,0153493 ! trans-Golgi network GO:0005802 31 27 0,000 0,01148252 0,01534367 ! transferase activity, transferring nitrogenous groups GO:0016769 29 27 0,000 0,01148252 0,01533805 ! spliceosomal snRNP biogenesis GO:0000387 29 27 0,000 0,01148252 0,01533244 ! solute:solute antiporter activity GO:0015300 28 27 0,000 0,01148252 0,01532683 ! vasculogenesis GO:0001570 32 27 0,000 0,01148252 0,01532122 ! hexose transport GO:0008645 28 27 0,000 0,01148252 0,01531562 GO:0015749|monosaccharide transport, ! regulation of innate immune response GO:0045088 28 27 0,000 0,01148252 0,01531002 ! spindle organization GO:0007051 38 27 0,000 0,01148252 0,01530443 ! cellular response to oxidative stress GO:0034599 32 27 0,000 0,01148252 0,01529884 ! response to organic cyclic substance GO:0014070 34 27 0,000 0,01148252 0,01529326 ! cell fate determination GO:0001709 29 27 0,000 0,01148252 0,01528767 ! lipid oxidation GO:0034440 29 27 0,000 0,01148252 0,0152821 GO:0019395|fatty acid oxidation, ! fatty acid catabolic process GO:0009062 31 27 0,000 0,01148252 0,01527652 ! collagen binding GO:0005518 29 27 0,000 0,01148252 0,01527095 ! carboxy-lyase activity GO:0016831 27 27 0,000 0,01148252 0,01526539 ! phospholipid transporter activity GO:0005548 30 27 0,000 0,01148252 0,01525983 ! liver development GO:0001889 33 27 0,000 0,01148252 0,01525427 ! mitotic sister chromatid segregation GO:0000070 46 27 0,000 0,01148252 0,01524872 ! determination of bilateral symmetry GO:0009855 32 27 0,000 0,01148252 0,01524317 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! integrin complex GO:0008305 30 27 0,000 0,01148252 0,01523762 ! membrane docking GO:0022406 29 27 0,000 0,01148252 0,01523208 ! detection of light stimulus involved in sensory perception GO:0050962 29 27 0,000 0,01148252 0,01522655 GO:0050908|detection of light stimulus involved in visual perception, ! multicellular organismal macromolecule metabolic process GO:0044259 28 27 0,000 0,01148252 0,01522101 ! respiratory gaseous exchange GO:0007585 30 27 0,000 0,01148252 0,01521548 ! phospholipid transport GO:0015914 29 27 0,000 0,01148252 0,01520996 ! sarcoplasmic reticulum GO:0016529 29 27 0,000 0,01148252 0,01520444 ! aminopeptidase activity GO:0004177 33 27 0,000 0,01148252 0,01519892 ! cellular response to nutrient levels GO:0031669 28 27 0,000 0,01148252 0,01519341 ! RNA polymerase II transcription factor activity, enhancer binding GO:0003705 33 27 0,000 0,01148252 0,0151879 ! biogenic amine biosynthetic process GO:0042401 29 27 0,000 0,01148252 0,01518239 ! negative regulation of transcription regulator activity GO:0090048 32 27 0,000 0,01148252 0,01517689 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of immune effector process GO:0002699 29 27 0,000 0,01148252 0,0151714 ! ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 31 28 0,000 0,01190557 0,01572467 ! Golgi stack GO:0005795 30 28 0,000 0,01190557 0,01571897 ! male gonad development GO:0008584 32 28 0,000 0,01190557 0,01571329 ! regulation of fatty acid metabolic process GO:0019217 41 28 0,000 0,01190557 0,0157076 ! lipoprotein binding GO:0008034 31 28 0,000 0,01190557 0,01570193 ! mesoderm formation GO:0001707 34 28 0,000 0,01190557 0,01569625 ! negative regulation of MAP kinase activity GO:0043407 30 28 0,000 0,01190557 0,01569058 ! peptidyl-tyrosine modification GO:0018212 32 28 0,000 0,01190557 0,01568491 ! deoxyribonuclease activity GO:0004536 56 28 0,000 0,01190557 0,01567925 ! nicotinamide metabolic process GO:0006769 32 28 0,000 0,01190557 0,01567359 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 31 28 0,000 0,01190557 0,01566794 ! regulation of osteoblast differentiation GO:0045667 33 28 0,000 0,01190557 0,01566229 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0016814 30 28 0,000 0,01190557 0,01565664 ! negative regulation of neuron apoptosis GO:0043524 39 28 0,000 0,01190557 0,015651 ! tissue homeostasis GO:0001894 31 28 0,000 0,01190557 0,01564536 GO:0048871|multicellular organismal homeostasis, ! DNA damage checkpoint GO:0000077 48 28 0,000 0,01190557 0,01563973 ! negative regulation of protein complex assembly GO:0031333 39 28 0,000 0,01190557 0,0156341 ! regulation of carbohydrate metabolic process GO:0006109 31 28 0,000 0,01190557 0,01562847 ! sister chromatid segregation GO:0000819 49 28 0,000 0,01190557 0,01562285 ! post-embryonic development GO:0009791 32 28 0,000 0,01190557 0,01561723 ! complement activation, classical pathway GO:0006958 33 28 0,000 0,01190557 0,01561162 ! negative regulation of phosphorylation GO:0042326 30 28 0,000 0,01190557 0,01560601 ! detection of visible light GO:0009584 30 28 0,000 0,01190557 0,0156004 ! calcium-mediated signaling GO:0019722 30 28 0,000 0,01190557 0,0155948 ! receptor regulator activity GO:0030545 31 28 0,000 0,01190557 0,01558921 ! acetylgalactosaminyltransferase activity GO:0008376 33 28 0,000 0,01190557 0,01558361 ! symbiosis, encompassing mutualism through parasitism GO:0044403 33 28 0,000 0,01190557 0,01557802 ! response to heat GO:0009408 33 28 0,000 0,01190557 0,01557244 ! response to xenobiotic stimulus GO:0009410 31 28 0,000 0,01190557 0,01556686 ! response to hydrogen peroxide GO:0042542 32 29 0,000 0,01232847 0,01611403 ! hormone binding GO:0042562 31 29 0,000 0,01232847 0,01610825 ! establishment or maintenance of cell polarity GO:0007163 34 29 0,000 0,01232847 0,01610249 ! striated muscle cell differentiation GO:0051146 42 29 0,000 0,01232847 0,01609672 ! NADP or NADPH binding GO:0050661 33 29 0,000 0,01232847 0,01609097 ! nucleotide receptor activity, G-protein coupled GO:0001608 31 29 0,000 0,01232847 0,01608521 GO:0045028|purinergic nucleotide receptor activity, G-protein coupled, ! mitochondrial intermembrane space GO:0005758 41 29 0,000 0,01232847 0,01607946 ! erythrocyte differentiation GO:0030218 35 29 0,000 0,01232847 0,01607371 ! ceramide metabolic process GO:0006672 29 29 0,000 0,01232847 0,01606797 ! replication fork GO:0005657 42 29 0,000 0,01232847 0,01606223 ! camera-type eye morphogenesis GO:0048593 36 29 0,000 0,01232847 0,0160565 ! monosaccharide biosynthetic process GO:0046364 35 29 0,000 0,01232847 0,01605077 ! negative regulation of lymphocyte activation GO:0051250 32 29 0,000 0,01232847 0,01604504 ! alkaloid metabolic process GO:0009820 33 29 0,000 0,01232847 0,01603932 ! icosanoid biosynthetic process GO:0046456 30 29 0,000 0,01232847 0,0160336 ! regulation of pH GO:0006885 30 29 0,000 0,01232847 0,01602789 ! amino sugar metabolic process GO:0006040 41 29 0,000 0,01232847 0,01602218 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 34 29 0,000 0,01232847 0,01601647 ! phospholipase C activity GO:0004629 43 29 0,000 0,01232847 0,01601077 ! response to mechanical stimulus GO:0009612 33 29 0,000 0,01232847 0,01600507 ! clathrin coated vesicle membrane GO:0030665 33 29 0,000 0,01232847 0,01599938 ! sodium channel activity GO:0005272 33 29 0,000 0,01232847 0,01599369 ! sarcoplasm GO:0016528 31 29 0,000 0,01232847 0,015988 ! detection of light stimulus GO:0009583 31 29 0,000 0,01232847 0,01598232 ! spermatid development GO:0007286 30 29 0,000 0,01232847 0,01597664 ! DNA polymerase activity GO:0034061 34 29 0,000 0,01232847 0,01597097 ! peptidyl-prolyl cis-trans isomerase activity GO:0003755 31 29 0,000 0,01232847 0,0159653 ! sarcolemma GO:0042383 30 29 0,000 0,01232847 0,01595963 ! tumor necrosis factor receptor superfamily binding GO:0032813 31 29 0,000 0,01232847 0,01595397 ! galactosyltransferase activity GO:0008378 33 29 0,000 0,01232847 0,01594831 ! establishment of vesicle localization GO:0051650 30 29 0,000 0,01232847 0,01594266 ! transforming growth factor beta receptor signaling pathway GO:0007179 34 30 0,000 0,0127512 0,01648348 ! mitochondrial nucleoid GO:0042645 44 30 0,000 0,0127512 0,01647764 GO:0009295|nucleoid, ! cholesterol transport GO:0030301 33 30 0,000 0,0127512 0,01647181 GO:0015918|sterol transport, ! histone-lysine N-methyltransferase activity GO:0018024 34 30 0,000 0,0127512 0,01646598 GO:0016278|lysine N-methyltransferase activity, GO:0016279|protein-lysine N-methyltransferase activity, ! cellular carbohydrate biosynthetic process GO:0034637 30 30 0,000 0,0127512 0,01646015 ! scavenger receptor activity GO:0005044 39 30 0,000 0,0127512 0,01645433 ! spliceosome assembly GO:0000245 34 30 0,000 0,0127512 0,01644851 ! oxidoreductase activity, acting on peroxide as acceptor GO:0016684 39 30 0,000 0,0127512 0,0164427 GO:0004601|peroxidase activity, ! mesoderm morphogenesis GO:0048332 37 30 0,000 0,0127512 0,01643689 ! metanephros development GO:0001656 31 30 0,000 0,0127512 0,01643108 ! glutamate receptor activity GO:0008066 35 30 0,000 0,0127512 0,01642528 ! cyclic nucleotide metabolic process GO:0009187 31 30 0,000 0,0127512 0,01641948 ! positive regulation of MAPKKK cascade GO:0043410 36 30 0,000 0,0127512 0,01641369 ! regulation of macrophage differentiation GO:0045649 37 30 0,000 0,0127512 0,0164079 ! positive regulation of myeloid cell differentiation GO:0045639 37 30 0,000 0,0127512 0,01640211 ! negative regulation of myeloid cell differentiation GO:0045638 35 30 0,000 0,0127512 0,01639633 ! cis-trans isomerase activity GO:0016859 32 30 0,000 0,0127512 0,01639055 ! myeloid leukocyte activation GO:0002274 36 30 0,000 0,0127512 0,01638478 ! negative regulation of protein transport GO:0051224 34 30 0,000 0,0127512 0,01637901 ! condensed nuclear chromosome GO:0000794 31 30 0,000 0,0127512 0,01637325 ! cortical cytoskeleton GO:0030863 33 30 0,000 0,0127512 0,01636748 ! protein-lipid complex GO:0032994 41 30 0,000 0,0127512 0,01636173 GO:0034358|plasma lipoprotein particle, ! circadian rhythm GO:0007623 37 30 0,000 0,0127512 0,01635597 ! phosphatase binding GO:0019902 34 30 0,000 0,0127512 0,01635023 ! acute-phase response GO:0006953 44 30 0,000 0,0127512 0,01634448 ! segmentation GO:0035282 37 30 0,000 0,0127512 0,01633874 ! response to toxin GO:0009636 33 30 0,000 0,0127512 0,016333 ! cation-transporting ATPase activity GO:0019829 32 30 0,000 0,0127512 0,01632727 ! antigen binding GO:0003823 33 30 0,000 0,0127512 0,01632154 ! regulation of systemic arterial blood pressure GO:0003073 33 30 0,000 0,0127512 0,01631582 ! Golgi-associated vesicle membrane GO:0030660 37 30 0,000 0,0127512 0,0163101 ! ensheathment of neurons GO:0007272 35 30 0,000 0,0127512 0,01630438 GO:0008366|axon ensheathment, ! JAK-STAT cascade GO:0007259 43 30 0,000 0,0127512 0,01629867 ! vesicle localization GO:0051648 31 30 0,000 0,0127512 0,01629296 ! negative regulation of cell adhesion GO:0007162 34 31 0,000 0,01317378 0,01682702 ! maintenance of protein location in cell GO:0032507 32 31 0,000 0,01317378 0,01682113 ! negative regulation of phosphorus metabolic process GO:0010563 34 31 0,000 0,01317378 0,01681524 GO:0045936|negative regulation of phosphate metabolic process, ! acrosomal vesicle GO:0001669 34 31 0,000 0,01317378 0,01680936 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,01317378 0,01680348 ! protein targeting to membrane GO:0006612 35 31 0,000 0,01317378 0,01679761 ! regulation of axonogenesis GO:0050770 37 31 0,000 0,01317378 0,01679174 ! regulation of T cell differentiation GO:0045580 43 31 0,000 0,01317378 0,01678587 ! formation of primary germ layer GO:0001704 37 31 0,000 0,01317378 0,01678001 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0016903 33 31 0,000 0,01317378 0,01677416 ! endocytic vesicle GO:0030139 33 31 0,000 0,01317378 0,0167683 ! pyridine nucleotide metabolic process GO:0019362 35 31 0,000 0,01317378 0,01676245 ! spermatid differentiation GO:0048515 32 31 0,000 0,01317378 0,01675661 ! negative regulation of catabolic process GO:0009895 34 31 0,000 0,01317378 0,01675077 ! neuron fate commitment GO:0048663 44 31 0,000 0,01317378 0,01674493 ! regulation of cellular catabolic process GO:0031329 35 31 0,000 0,01317378 0,0167391 ! regulation of JAK-STAT cascade GO:0046425 37 31 0,000 0,01317378 0,01673327 ! morphogenesis of embryonic epithelium GO:0016331 36 31 0,000 0,01317378 0,01672745 ! macromolecular complex disassembly GO:0032984 37 31 0,000 0,01317378 0,01672163 ! cell junction assembly GO:0034329 36 31 0,000 0,01317378 0,01671581 ! drug binding GO:0008144 34 31 0,000 0,01317378 0,01671 ! positive regulation of T cell proliferation GO:0042102 38 31 0,000 0,01317378 0,01670419 ! peptide transport GO:0015833 36 31 0,000 0,01317378 0,01669839 ! DNA integrity checkpoint GO:0031570 51 31 0,000 0,01317378 0,01669259 ! peripheral nervous system development GO:0007422 35 31 0,000 0,01317378 0,01668679 ! I band GO:0031674 34 31 0,000 0,01317378 0,016681 ! BMP signaling pathway GO:0030509 33 31 0,000 0,01317378 0,01667521 ! adult locomotory behavior GO:0008344 37 31 0,000 0,01317378 0,01666943 ! gene silencing GO:0016458 33 31 0,000 0,01317378 0,01666365 ! negative regulation of adenylate cyclase activity GO:0007194 39 32 0,000 0,0135962 0,01719201 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of secretion GO:0051048 37 32 0,000 0,0135962 0,01718605 ! negative regulation of DNA metabolic process GO:0051053 38 32 0,000 0,0135962 0,0171801 ! phosphotransferase activity, phosphate group as acceptor GO:0016776 49 32 0,000 0,0135962 0,01717415 ! meiosis I GO:0007127 53 32 0,000 0,0135962 0,01716821 ! GPI anchor biosynthetic process GO:0006506 35 32 0,000 0,0135962 0,01716227 GO:0006505|GPI anchor metabolic process, ! unsaturated fatty acid biosynthetic process GO:0006636 33 32 0,000 0,0135962 0,01715633 ! sterol biosynthetic process GO:0016126 40 32 0,000 0,0135962 0,0171504 ! vesicle coat GO:0030120 39 32 0,000 0,0135962 0,01714447 ! cytokine production GO:0001816 32 32 0,000 0,0135962 0,01713854 ! regulation of calcium ion transport GO:0051924 37 32 0,000 0,0135962 0,01713262 ! proteoglycan metabolic process GO:0006029 34 32 0,000 0,0135962 0,01712671 ! sphingoid metabolic process GO:0046519 33 32 0,000 0,0135962 0,0171208 ! multicellular organismal metabolic process GO:0044236 35 32 0,000 0,0135962 0,01711489 ! oxygen binding GO:0019825 33 32 0,000 0,0135962 0,01710898 ! leukocyte chemotaxis GO:0030595 32 32 0,000 0,0135962 0,01710308 GO:0060326|cell chemotaxis, ! negative regulation of leukocyte activation GO:0002695 35 32 0,000 0,0135962 0,01709719 ! hormone biosynthetic process GO:0042446 32 32 0,000 0,0135962 0,0170913 ! double-stranded RNA binding GO:0003725 35 32 0,000 0,0135962 0,01708541 ! microtubule organizing center part GO:0044450 46 32 0,000 0,0135962 0,01707953 ! platelet alpha granule lumen GO:0031093 35 33 0,000 0,01401846 0,01760391 ! DNA helicase activity GO:0003678 55 33 0,000 0,01401846 0,01759785 ! neural tube development GO:0021915 37 33 0,000 0,01401846 0,0175918 ! oxidoreductase activity, acting on sulfur group of donors GO:0016667 34 33 0,000 0,01401846 0,01758575 ! pigment biosynthetic process GO:0046148 35 33 0,000 0,01401846 0,0175797 ! organelle envelope lumen GO:0031970 46 33 0,000 0,01401846 0,01757366 ! regulation of cellular ketone metabolic process GO:0010565 46 33 0,000 0,01401846 0,01756763 ! negative regulation of DNA binding GO:0043392 39 33 0,000 0,01401846 0,01756159 ! NAD or NADH binding GO:0051287 36 33 0,000 0,01401846 0,01755556 ! nucleotide catabolic process GO:0009166 35 33 0,000 0,01401846 0,01754954 ! B cell differentiation GO:0030183 37 33 0,000 0,01401846 0,01754352 ! regulation of Wnt receptor signaling pathway GO:0030111 36 33 0,000 0,01401846 0,0175375 ! aerobic respiration GO:0009060 35 33 0,000 0,01401846 0,01753149 ! embryonic organ development GO:0048568 41 33 0,000 0,01401846 0,01752548 ! placenta development GO:0001890 39 33 0,000 0,01401846 0,01751948 ! protein serine/threonine phosphatase complex GO:0008287 37 33 0,000 0,01401846 0,01751348 ! tissue remodeling GO:0048771 37 33 0,000 0,01401846 0,01750748 ! flagellum GO:0019861 34 33 0,000 0,01401846 0,01750149 ! L-amino acid transmembrane transporter activity GO:0015179 37 33 0,000 0,01401846 0,0174955 ! Rho protein signal transduction GO:0007266 35 33 0,000 0,01401846 0,01748952 ! cysteine-type endopeptidase inhibitor activity GO:0004869 35 33 0,000 0,01401846 0,01748354 ! odontogenesis GO:0042476 39 34 0,000 0,01444057 0,01800382 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,01444057 0,01799767 ! lipid homeostasis GO:0055088 37 34 0,000 0,01444057 0,01799153 ! telencephalon development GO:0021537 36 34 0,000 0,01444057 0,01798538 ! clathrin coat GO:0030118 41 34 0,000 0,01444057 0,01797925 ! cell growth GO:0016049 36 34 0,000 0,01444057 0,01797311 ! regulation of B cell activation GO:0050864 40 34 0,000 0,01444057 0,01796698 ! protein polymerization GO:0051258 38 34 0,000 0,01444057 0,01796086 ! condensed chromosome kinetochore GO:0000777 52 34 0,000 0,01444057 0,01795473 ! learning GO:0007612 51 34 0,000 0,01444057 0,01794862 ! keratinization GO:0031424 40 34 0,000 0,01444057 0,0179425 ! ovulation cycle process GO:0022602 35 34 0,000 0,01444057 0,01793639 ! regulation of striated muscle tissue development GO:0016202 40 34 0,000 0,01444057 0,01793029 ! steroid hormone receptor binding GO:0035258 44 34 0,000 0,01444057 0,01792419 ! regulation of protein import into nucleus GO:0042306 36 34 0,000 0,01444057 0,01791809 ! erythrocyte homeostasis GO:0034101 40 34 0,000 0,01444057 0,017912 ! amino acid binding GO:0016597 40 34 0,000 0,01444057 0,01790591 ! regulation of protein stability GO:0031647 35 34 0,000 0,01444057 0,01789983 ! specific RNA polymerase II transcription factor activity GO:0003704 41 34 0,000 0,01444057 0,01789375 ! glycogen metabolic process GO:0005977 48 34 0,000 0,01444057 0,01788767 ! pyrimidine nucleotide metabolic process GO:0006220 41 34 0,000 0,01444057 0,0178816 ! acetylglucosaminyltransferase activity GO:0008375 40 34 0,000 0,01444057 0,01787553 ! epithelial tube morphogenesis GO:0060562 38 34 0,000 0,01444057 0,01786947 ! positive regulation of transcription factor activity GO:0051091 49 35 0,000 0,01486251 0,01838537 GO:0090047|positive regulation of transcription regulator activity, ! positive regulation of DNA metabolic process GO:0051054 53 35 0,000 0,01486251 0,01837914 ! response to estrogen stimulus GO:0043627 48 35 0,000 0,01486251 0,01837291 ! inner ear morphogenesis GO:0042472 46 35 0,000 0,01486251 0,01836668 ! MHC protein complex GO:0042611 50 35 0,000 0,01486251 0,01836046 ! alcohol biosynthetic process GO:0046165 41 35 0,000 0,01486251 0,01835425 ! vesicle lumen GO:0031983 38 35 0,000 0,01486251 0,01834804 GO:0060205|cytoplasmic membrane-bounded vesicle lumen, ! female gonad development GO:0008585 37 35 0,000 0,01486251 0,01834183 ! mesenchymal cell development GO:0014031 40 35 0,000 0,01486251 0,01833563 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! neutral lipid metabolic process GO:0006638 47 35 0,000 0,01486251 0,01832943 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 37 35 0,000 0,01486251 0,01832323 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 41 35 0,000 0,01486251 0,01831704 ! regulation of proteolysis GO:0030162 37 35 0,000 0,01486251 0,01831086 ! ovulation cycle GO:0042698 37 35 0,000 0,01486251 0,01830468 ! intramolecular oxidoreductase activity GO:0016860 35 35 0,000 0,01486251 0,0182985 ! positive regulation of catabolic process GO:0009896 38 35 0,000 0,01486251 0,01829232 ! collagen GO:0005581 54 35 0,000 0,01486251 0,01828615 ! glucan metabolic process GO:0044042 49 35 0,000 0,01486251 0,01827999 GO:0006073|cellular glucan metabolic process, ! regulation of muscle development GO:0048634 42 35 0,000 0,01486251 0,01827383 ! ER to Golgi vesicle-mediated transport GO:0006888 43 35 0,000 0,01486251 0,01826767 ! histone methyltransferase activity GO:0042054 40 35 0,000 0,01486251 0,01826152 ! cation:sugar symporter activity GO:0005402 37 35 0,000 0,01486251 0,01825537 GO:0005351|sugar:hydrogen symporter activity, ! carbohydrate homeostasis GO:0033500 49 35 0,000 0,01486251 0,01824923 GO:0042593|glucose homeostasis, ! cytosolic small ribosomal subunit GO:0022627 36 35 0,000 0,01486251 0,01824309 ! maintenance of protein location GO:0045185 45 35 0,000 0,01486251 0,01823695 ! polyol metabolic process GO:0019751 46 35 0,000 0,01486251 0,01823082 ! androgen receptor signaling pathway GO:0030521 47 35 0,000 0,01486251 0,01822469 ! cytokinesis GO:0000910 38 35 0,000 0,01486251 0,01821856 ! O-acyltransferase activity GO:0008374 36 35 0,000 0,01486251 0,01821245 ! purinergic nucleotide receptor activity GO:0001614 40 36 0,000 0,0152843 0,01872301 GO:0016502|nucleotide receptor activity, ! mitochondrial respiratory chain complex I GO:0005747 37 36 0,000 0,0152843 0,01871673 GO:0030964|NADH dehydrogenase complex, GO:0045271|respiratory chain complex I, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 42 36 0,000 0,0152843 0,01871045 ! positive regulation of neurogenesis GO:0050769 38 36 0,000 0,0152843 0,01870417 ! SMAD binding GO:0046332 39 36 0,000 0,0152843 0,0186979 ! negative regulation of cell activation GO:0050866 40 36 0,000 0,0152843 0,01869163 ! inositol or phosphatidylinositol kinase activity GO:0004428 51 36 0,000 0,0152843 0,01868537 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 41 36 0,000 0,0152843 0,01867911 GO:0006956|complement activation, ! glial cell differentiation GO:0010001 38 36 0,000 0,0152843 0,01867285 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 36 0,000 0,0152843 0,0186666 ! hormone-mediated signaling GO:0009755 41 36 0,000 0,0152843 0,01866035 ! nucleus organization GO:0006997 42 36 0,000 0,0152843 0,01865411 ! di-, tri-valent inorganic cation transmembrane transporter activity GO:0015082 42 36 0,000 0,0152843 0,01864787 ! carboxypeptidase activity GO:0004180 37 36 0,000 0,0152843 0,01864163 ! cellular response to extracellular stimulus GO:0031668 37 36 0,000 0,0152843 0,0186354 ! energy coupled proton transport, down electrochemical gradient GO:0015985 37 36 0,000 0,0152843 0,01862918 GO:0015986|ATP synthesis coupled proton transport, ! female gamete generation GO:0007292 39 36 0,000 0,0152843 0,01862296 ! positive regulation of mast cell proliferation GO:0070668 43 36 0,000 0,0152843 0,01861674 GO:0050671|positive regulation of lymphocyte proliferation, ! maintenance of location in cell GO:0051651 38 36 0,000 0,0152843 0,01861052 ! activation of adenylate cyclase activity GO:0007190 44 37 0,000 0,01570593 0,01911753 ! regulation of hormone secretion GO:0046883 43 37 0,000 0,01570593 0,01911115 ! sugar transmembrane transporter activity GO:0051119 39 37 0,000 0,01570593 0,01910478 GO:0015144|carbohydrate transmembrane transporter activity, ! regulation of Rab protein signal transduction GO:0032483 40 37 0,000 0,01570593 0,01909841 GO:0032313|regulation of Rab GTPase activity, ! regulation of action potential in neuron GO:0019228 44 37 0,000 0,01570593 0,01909205 ! glycerol ether metabolic process GO:0006662 49 37 0,000 0,01570593 0,01908569 ! endoribonuclease activity GO:0004521 48 37 0,000 0,01570593 0,01907933 ! hindbrain development GO:0030902 43 37 0,000 0,01570593 0,01907298 ! isoprenoid metabolic process GO:0006720 41 37 0,000 0,01570593 0,01906663 ! pigmentation GO:0043473 51 37 0,000 0,01570593 0,01906029 ! regulation of neuron projection development GO:0010975 43 37 0,000 0,01570593 0,01905395 ! condensed chromosome, centromeric region GO:0000779 55 37 0,000 0,01570593 0,01904762 ! metalloexopeptidase activity GO:0008235 39 37 0,000 0,01570593 0,01904129 ! monocarboxylic acid transport GO:0015718 43 37 0,000 0,01570593 0,01903496 ! sensory perception of taste GO:0050909 37 37 0,000 0,01570593 0,01902864 ! cell junction organization GO:0034330 44 37 0,000 0,01570593 0,01902232 ! skeletal muscle fiber development GO:0048741 41 37 0,000 0,01570593 0,01901601 ! development of primary female sexual characteristics GO:0046545 40 37 0,000 0,01570593 0,0190097 GO:0046660|female sex differentiation, ! NADH dehydrogenase (ubiquinone) activity GO:0008137 38 37 0,000 0,01570593 0,01900339 GO:0050136|NADH dehydrogenase (quinone) activity, GO:0003954|NADH dehydrogenase activity, ! ion transmembrane transport GO:0034220 38 37 0,000 0,01570593 0,01899709 ! regulation of lymphocyte mediated immunity GO:0002706 43 37 0,000 0,01570593 0,0189908 ! coated pit GO:0005905 44 37 0,000 0,01570593 0,0189845 ! positive regulation of leukocyte proliferation GO:0070665 47 37 0,000 0,01570593 0,01897822 GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of adenylate cyclase activity GO:0045762 45 38 0,000 0,0161274 0,01948105 ! regulation of translational initiation GO:0006446 50 38 0,000 0,0161274 0,0194746 ! negative regulation of binding GO:0051100 44 38 0,000 0,0161274 0,01946815 ! organic ether metabolic process GO:0018904 50 38 0,000 0,0161274 0,01946171 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 43 38 0,000 0,0161274 0,01945528 ! regulation of lymphocyte differentiation GO:0045619 51 38 0,000 0,0161274 0,01944885 ! carbon-carbon lyase activity GO:0016830 41 38 0,000 0,0161274 0,01944242 ! hydro-lyase activity GO:0016836 44 38 0,000 0,0161274 0,019436 ! synapse organization GO:0050808 43 38 0,000 0,0161274 0,01942958 ! viral infectious cycle GO:0019058 40 38 0,000 0,0161274 0,01942316 ! phosphoinositide biosynthetic process GO:0046489 41 38 0,000 0,0161274 0,01941675 ! organic anion transport GO:0015711 42 38 0,000 0,0161274 0,01941035 ! monosaccharide binding GO:0048029 41 38 0,000 0,0161274 0,01940395 ! muscle fiber development GO:0048747 42 38 0,000 0,0161274 0,01939755 ! development of primary male sexual characteristics GO:0046546 46 38 0,000 0,0161274 0,01939115 ! phagocytosis GO:0006909 44 38 0,000 0,0161274 0,01938477 ! regulation of ARF protein signal transduction GO:0032012 44 38 0,000 0,0161274 0,01937838 ! general RNA polymerase II transcription factor activity GO:0016251 43 38 0,000 0,0161274 0,019372 ! DNA-directed RNA polymerase activity GO:0003899 49 38 0,000 0,0161274 0,01936562 GO:0034062|RNA polymerase activity, ! extrinsic to plasma membrane GO:0019897 43 38 0,000 0,0161274 0,01935925 ! cytosolic large ribosomal subunit GO:0022625 43 38 0,000 0,0161274 0,01935288 ! Rab GTPase activator activity GO:0005097 41 38 0,000 0,0161274 0,01934652 ! cellular response to insulin stimulus GO:0032869 47 38 0,000 0,0161274 0,01934016 ! monocarboxylic acid binding GO:0033293 44 39 0,000 0,01654872 0,01983888 ! induction of apoptosis by extracellular signals GO:0008624 44 39 0,000 0,01654872 0,01983236 ! heterocycle biosynthetic process GO:0018130 51 39 0,000 0,01654872 0,01982585 ! positive regulation of DNA binding GO:0043388 53 39 0,000 0,01654872 0,01981934 ! T cell differentiation GO:0030217 64 39 0,000 0,01654872 0,01981284 ! DNA-dependent ATPase activity GO:0008094 63 39 0,000 0,01654872 0,01980634 ! cell fate specification GO:0001708 55 39 0,000 0,01654872 0,01979984 ! positive regulation of cyclase activity GO:0031281 46 39 0,000 0,01654872 0,01979335 ! regulation of adaptive immune response GO:0002819 44 39 0,000 0,01654872 0,01978686 ! regulation of cell morphogenesis involved in differentiation GO:0010769 45 39 0,000 0,01654872 0,01978038 ! receptor-mediated endocytosis GO:0006898 44 39 0,000 0,01654872 0,0197739 ! regulation of metal ion transport GO:0010959 45 39 0,000 0,01654872 0,01976742 ! energy reserve metabolic process GO:0006112 53 39 0,000 0,01654872 0,01976095 ! amine receptor activity GO:0008227 48 39 0,000 0,01654872 0,01975449 ! cytoskeleton-dependent intracellular transport GO:0030705 42 39 0,000 0,01654872 0,01974803 ! embryonic skeletal system morphogenesis GO:0048704 46 39 0,000 0,01654872 0,01974157 ! neuropeptide receptor activity GO:0008188 41 39 0,000 0,01654872 0,01973511 ! double-strand break repair GO:0006302 70 39 0,000 0,01654872 0,01972866 ! pigment metabolic process GO:0042440 43 39 0,000 0,01654872 0,01972222 ! RNA modification GO:0009451 39 39 0,000 0,01654872 0,01971578 ! damaged DNA binding GO:0003684 51 40 0,000 0,01696987 0,02021093 ! regulation of intracellular protein transport GO:0033157 43 40 0,000 0,01696987 0,02020434 ! peroxisomal membrane GO:0005778 44 40 0,000 0,01696987 0,02019775 GO:0031903|microbody membrane, ! actin filament binding GO:0051015 41 40 0,000 0,01696987 0,02019116 ! positive regulation of cell development GO:0010720 43 40 0,000 0,01696987 0,02018457 ! ribonucleoside metabolic process GO:0009119 47 40 0,000 0,01696987 0,020178 ! biopolymer methylation GO:0043414 45 40 0,000 0,01696987 0,02017142 ! neuron migration GO:0001764 43 40 0,000 0,01696987 0,02016485 ! regulation of protein secretion GO:0050708 45 40 0,000 0,01696987 0,02015828 ! oxidoreduction coenzyme metabolic process GO:0006733 45 40 0,000 0,01696987 0,02015172 ! dorsal/ventral pattern formation GO:0009953 42 40 0,000 0,01696987 0,02014516 ! regulation of actin filament polymerization GO:0030833 53 40 0,000 0,01696987 0,02013861 ! positive regulation of defense response GO:0031349 41 40 0,000 0,01696987 0,02013206 ! mammary gland development GO:0030879 47 40 0,000 0,01696987 0,02012552 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 50 40 0,000 0,01696987 0,02011898 ! neuropeptide binding GO:0042923 42 40 0,000 0,01696987 0,02011244 ! regulation of tube size GO:0035150 44 40 0,000 0,01696987 0,02010591 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 42 40 0,000 0,01696987 0,02009938 ! positive regulation of gene-specific transcription GO:0043193 46 40 0,000 0,01696987 0,02009286 ! regulation of leukocyte mediated immunity GO:0002703 46 40 0,000 0,01696987 0,02008634 ! inorganic anion transmembrane transporter activity GO:0015103 43 40 0,000 0,01696987 0,02007982 ! chromatin remodeling GO:0006338 44 40 0,000 0,01696987 0,02007331 ! solute:hydrogen symporter activity GO:0015295 44 40 0,000 0,01696987 0,0200668 ! protein amino acid N-linked glycosylation GO:0006487 46 41 0,000 0,01739087 0,02055797 ! Notch signaling pathway GO:0007219 46 41 0,000 0,01739087 0,02055131 ! keratin filament GO:0045095 44 41 0,000 0,01739087 0,02054465 ! peptide metabolic process GO:0006518 42 41 0,000 0,01739087 0,020538 ! polysaccharide biosynthetic process GO:0000271 42 41 0,000 0,01739087 0,02053136 ! late endosome membrane GO:0031902 45 41 0,000 0,01739087 0,02052471 ! icosanoid metabolic process GO:0006690 51 41 0,000 0,01739087 0,02051808 ! positive regulation of lyase activity GO:0051349 48 41 0,000 0,01739087 0,02051144 ! integral to endoplasmic reticulum membrane GO:0030176 43 41 0,000 0,01739087 0,02050481 ! glycolysis GO:0006096 43 41 0,000 0,01739087 0,02049819 ! branching morphogenesis of a tube GO:0048754 54 41 0,000 0,01739087 0,02049157 ! nucleobase, nucleoside, nucleotide kinase activity GO:0019205 51 41 0,000 0,01739087 0,02048495 ! proton-transporting two-sector ATPase complex GO:0016469 42 41 0,000 0,01739087 0,02047834 ! response to reactive oxygen species GO:0000302 49 42 0,000 0,01781171 0,02096712 ! cellular amide metabolic process GO:0043603 56 42 0,000 0,01781171 0,02096036 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor GO:0016655 43 42 0,000 0,01781171 0,0209536 ! ER-Golgi intermediate compartment GO:0005793 52 42 0,000 0,01781171 0,02094685 ! regulation of multicellular organism growth GO:0040014 46 42 0,000 0,01781171 0,0209401 ! integral to Golgi membrane GO:0030173 55 42 0,000 0,01781171 0,02093335 ! developmental growth GO:0048589 45 42 0,000 0,01781171 0,02092661 ! structural constituent of muscle GO:0008307 46 42 0,000 0,01781171 0,02091987 ! mitochondrial transport GO:0006839 45 42 0,000 0,01781171 0,02091314 ! protein methyltransferase activity GO:0008276 49 42 0,000 0,01781171 0,02090641 ! metal cluster binding GO:0051540 47 42 0,000 0,01781171 0,02089968 GO:0051536|iron-sulfur cluster binding, ! feeding behavior GO:0007631 48 42 0,000 0,01781171 0,02089296 ! ribonucleoprotein complex assembly GO:0022618 47 42 0,000 0,01781171 0,02088625 ! RNA catabolic process GO:0006401 49 43 0,000 0,01823239 0,02137268 ! ear morphogenesis GO:0042471 56 43 0,000 0,01823239 0,02136581 ! cellular amino acid biosynthetic process GO:0008652 49 43 0,000 0,01823239 0,02135895 ! regulation of epithelial cell proliferation GO:0050678 50 43 0,000 0,01823239 0,02135209 ! cell recognition GO:0008037 51 43 0,000 0,01823239 0,02134524 ! positive regulation of cytokine production GO:0001819 46 43 0,000 0,01823239 0,02133839 ! epithelial cell differentiation GO:0030855 56 43 0,000 0,01823239 0,02133155 ! gliogenesis GO:0042063 46 43 0,000 0,01823239 0,02132471 ! endosome transport GO:0016197 48 43 0,000 0,01823239 0,02131787 ! striated muscle contraction GO:0006941 45 43 0,000 0,01823239 0,02131104 ! positive regulation of cytokine biosynthetic process GO:0042108 48 43 0,000 0,01823239 0,02130422 ! antioxidant activity GO:0016209 53 43 0,000 0,01823239 0,0212974 ! sulfur compound biosynthetic process GO:0044272 47 43 0,000 0,01823239 0,02129058 ! activation of caspase activity GO:0006919 60 43 0,000 0,01823239 0,02128377 ! vascular process in circulatory system GO:0003018 48 43 0,000 0,01823239 0,02127696 ! histone modification GO:0016570 45 43 0,000 0,01823239 0,02127015 ! cellular amino acid derivative biosynthetic process GO:0042398 55 43 0,000 0,01823239 0,02126335 ! regulation of nucleocytoplasmic transport GO:0046822 46 44 0,000 0,01865292 0,02174683 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 50 44 0,000 0,01865292 0,02173988 ! negative regulation of cell migration GO:0030336 53 44 0,000 0,01865292 0,02173294 ! ATP synthesis coupled electron transport GO:0042773 45 44 0,000 0,01865292 0,021726 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! nucleoside monophosphate biosynthetic process GO:0009124 50 44 0,000 0,01865292 0,02171907 ! chemokine activity GO:0008009 48 44 0,000 0,01865292 0,02171214 ! ruffle GO:0001726 50 44 0,000 0,01865292 0,02170521 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0015662 51 44 0,000 0,01865292 0,02169829 ! regulation of neuron apoptosis GO:0043523 58 44 0,000 0,01865292 0,02169137 ! cartilage development GO:0051216 48 44 0,000 0,01865292 0,02168446 ! membrane fusion GO:0006944 52 44 0,000 0,01865292 0,02167755 ! channel regulator activity GO:0016247 54 44 0,000 0,01865292 0,02167065 ! excretion GO:0007588 53 44 0,000 0,01865292 0,02166375 ! male sex differentiation GO:0046661 52 44 0,000 0,01865292 0,02165686 ! protein phosphatase regulator activity GO:0019888 50 44 0,000 0,01865292 0,02164996 ! RNA elongation from RNA polymerase II promoter GO:0006368 49 44 0,000 0,01865292 0,02164308 ! amino acid activation GO:0043038 45 44 0,000 0,01865292 0,0216362 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! microbody part GO:0044438 48 44 0,000 0,01865292 0,02162932 GO:0044439|peroxisomal part, ! positive regulation of binding GO:0051099 59 45 0,000 0,01907328 0,02210974 ! solute:sodium symporter activity GO:0015370 51 45 0,000 0,01907328 0,02210271 ! transferase activity, transferring pentosyl groups GO:0016763 50 45 0,000 0,01907328 0,02209569 ! organellar ribosome GO:0000313 46 45 0,000 0,01907328 0,02208868 GO:0005761|mitochondrial ribosome, ! platelet alpha granule GO:0031091 49 45 0,000 0,01907328 0,02208167 ! single-stranded DNA binding GO:0003697 48 45 0,000 0,01907328 0,02207466 ! intrinsic to Golgi membrane GO:0031228 60 45 0,000 0,01907328 0,02206766 ! transport vesicle GO:0030133 53 45 0,000 0,01907328 0,02206067 ! regulation of endocytosis GO:0030100 52 45 0,000 0,01907328 0,02205367 ! ligase activity, forming carbon-oxygen bonds GO:0016875 47 45 0,000 0,01907328 0,02204669 GO:0016876|ligase activity, forming aminoacyl-tRNA and related compounds, GO:0004812|aminoacyl-tRNA ligase activity, ! nuclear matrix GO:0016363 56 45 0,000 0,01907328 0,0220397 ! unsaturated fatty acid metabolic process GO:0033559 55 45 0,000 0,01907328 0,02203272 ! regulation of T cell proliferation GO:0042129 53 45 0,000 0,01907328 0,02202575 ! regulation of myeloid leukocyte differentiation GO:0002761 54 45 0,000 0,01907328 0,02201878 ! DNA-dependent DNA replication GO:0006261 66 45 0,000 0,01907328 0,02201181 ! coated vesicle membrane GO:0030662 52 45 0,000 0,01907328 0,02200485 ! covalent chromatin modification GO:0016569 47 45 0,000 0,01907328 0,02199789 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 51 45 0,000 0,01907328 0,02199094 ! synaptosome GO:0019717 50 45 0,000 0,01907328 0,02198399 ! chemokine receptor binding GO:0042379 50 45 0,000 0,01907328 0,02197705 ! regulation of action potential GO:0001508 56 46 0,000 0,01949349 0,02245414 ! immunoglobulin mediated immune response GO:0016064 51 46 0,000 0,01949349 0,02244705 ! phosphatase regulator activity GO:0019208 53 46 0,000 0,01949349 0,02243997 ! regulation of inflammatory response GO:0050727 49 46 0,000 0,01949349 0,02243289 ! eye morphogenesis GO:0048592 57 46 0,000 0,01949349 0,02242582 ! regulation of JNK cascade GO:0046328 53 46 0,000 0,01949349 0,02241875 ! methylation GO:0032259 51 46 0,000 0,01949349 0,02241168 ! positive regulation of protein transport GO:0051222 50 46 0,000 0,01949349 0,02240462 ! regulation of ion transport GO:0043269 54 46 0,000 0,01949349 0,02239756 ! leukocyte migration GO:0050900 49 46 0,000 0,01949349 0,02239051 ! neuromuscular process GO:0050905 56 46 0,000 0,01949349 0,02238346 ! sulfotransferase activity GO:0008146 54 46 0,000 0,01949349 0,02237642 ! JNK cascade GO:0007254 48 46 0,000 0,01949349 0,02236938 ! SH3/SH2 adaptor activity GO:0005070 52 46 0,000 0,01949349 0,02236235 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 54 47 0,000 0,01991355 0,02283704 ! auxiliary transport protein activity GO:0015457 58 47 0,000 0,01991355 0,02282986 ! regulation of actin polymerization or depolymerization GO:0008064 60 47 0,000 0,01991355 0,02282269 ! microtubule binding GO:0008017 61 47 0,000 0,01991355 0,02281552 ! morphogenesis of a branching structure GO:0001763 70 47 0,000 0,01991355 0,02280836 ! carbon-oxygen lyase activity GO:0016835 53 47 0,000 0,01991355 0,0228012 ! regulation of protein polymerization GO:0032271 60 47 0,000 0,01991355 0,02279404 ! viral reproductive process GO:0022415 53 47 0,000 0,01991355 0,02278689 ! RNA elongation GO:0006354 52 47 0,000 0,01991355 0,02277975 ! negative regulation of immune system process GO:0002683 58 47 0,000 0,01991355 0,02277261 ! mRNA binding GO:0003729 65 47 0,000 0,01991355 0,02276547 ! axon GO:0030424 53 48 0,000 0,02033344 0,02323822 ! protein amino acid lipidation GO:0006497 53 48 0,000 0,02033344 0,02323094 ! stress-activated protein kinase signaling pathway GO:0031098 50 48 0,000 0,02033344 0,02322367 ! proteasome complex GO:0000502 50 48 0,000 0,02033344 0,0232164 ! glutamine family amino acid metabolic process GO:0009064 62 48 0,000 0,02033344 0,02320913 ! protein homooligomerization GO:0051260 63 48 0,000 0,02033344 0,02320187 ! regulation of cell projection organization GO:0031344 54 48 0,000 0,02033344 0,02319462 ! kinetochore GO:0000776 69 48 0,000 0,02033344 0,02318737 ! positive regulation of caspase activity GO:0043280 65 48 0,000 0,02033344 0,02318012 GO:0010952|positive regulation of peptidase activity, ! detection of stimulus involved in sensory perception GO:0050906 53 48 0,000 0,02033344 0,02317288 ! growth factor receptor binding GO:0070851 58 48 0,000 0,02033344 0,02316564 ! N-methyltransferase activity GO:0008170 53 48 0,000 0,02033344 0,02315841 ! inner ear development GO:0048839 60 48 0,000 0,02033344 0,02315118 ! excitatory extracellular ligand-gated ion channel activity GO:0005231 57 48 0,000 0,02033344 0,02314396 ! amino acid transmembrane transporter activity GO:0015171 53 48 0,000 0,02033344 0,02313674 ! chromatin remodeling complex GO:0016585 54 48 0,000 0,02033344 0,02312953 ! B cell mediated immunity GO:0019724 53 48 0,000 0,02033344 0,02312232 ! steroid hormone receptor activity GO:0003707 61 48 0,000 0,02033344 0,02311511 ! regulation of cell shape GO:0008360 55 48 0,000 0,02033344 0,02310791 ! establishment of organelle localization GO:0051656 58 48 0,000 0,02033344 0,02310071 ! cell cortex part GO:0044448 54 48 0,000 0,02033344 0,02309352 ! transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016765 52 49 0,000 0,02075318 0,0235629 ! regulation of neurotransmitter levels GO:0001505 55 49 0,000 0,02075318 0,02355557 ! oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 54 49 0,000 0,02075318 0,02354824 ! response to temperature stimulus GO:0009266 57 49 0,000 0,02075318 0,02354092 ! Golgi-associated vesicle GO:0005798 59 49 0,000 0,02075318 0,0235336 ! lipid modification GO:0030258 55 49 0,000 0,02075318 0,02352629 ! synaptic vesicle GO:0008021 56 49 0,000 0,02075318 0,02351898 ! regulation of gene expression, epigenetic GO:0040029 64 49 0,000 0,02075318 0,02351167 ! pyridoxal phosphate binding GO:0030170 63 49 0,000 0,02075318 0,02350437 GO:0070279|vitamin B6 binding, ! exonuclease activity GO:0004527 79 49 0,000 0,02075318 0,02349708 ! maintenance of location GO:0051235 62 49 0,000 0,02075318 0,02348979 ! negative regulation of cell motion GO:0051271 60 49 0,000 0,02075318 0,0234825 ! regulation of actin filament length GO:0030832 62 49 0,000 0,02075318 0,02347522 ! nuclear periphery GO:0034399 60 49 0,000 0,02075318 0,02346794 ! regulation of muscle contraction GO:0006937 57 49 0,000 0,02075318 0,02346067 ! nucleotide-excision repair GO:0006289 53 49 0,000 0,02075318 0,0234534 ! regulation of mast cell proliferation GO:0070666 57 49 0,000 0,02075318 0,02344614 ! respiratory electron transport chain GO:0022904 51 50 0,000 0,02117276 0,02391276 ! cytokine-mediated signaling pathway GO:0019221 56 50 0,000 0,02117276 0,02390536 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016811 51 50 0,000 0,02117276 0,02389796 ! embryonic skeletal system development GO:0048706 59 50 0,000 0,02117276 0,02389057 ! glucose catabolic process GO:0006007 54 50 0,000 0,02117276 0,02388318 ! aging GO:0007568 92 50 0,000 0,02117276 0,0238758 ! generation of a signal involved in cell-cell signaling GO:0003001 59 50 0,000 0,02117276 0,02386842 ! heart morphogenesis GO:0003007 57 50 0,000 0,02117276 0,02386105 ! integrin binding GO:0005178 56 50 0,000 0,02117276 0,02385368 ! detection of abiotic stimulus GO:0009582 56 50 0,000 0,02117276 0,02384632 ! regulation of angiogenesis GO:0045765 56 51 0,000 0,02159218 0,02431119 ! positive regulation of cell migration GO:0030335 63 51 0,000 0,02159218 0,02430369 ! regulation of ossification GO:0030278 59 51 0,000 0,02159218 0,0242962 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 60 51 0,000 0,02159218 0,02428871 ! positive regulation of organelle organization GO:0010638 69 51 0,000 0,02159218 0,02428122 ! cellular polysaccharide metabolic process GO:0044264 65 51 0,000 0,02159218 0,02427374 ! endocrine system development GO:0035270 55 51 0,000 0,02159218 0,02426626 ! germ cell development GO:0007281 56 51 0,000 0,02159218 0,02425878 ! transferase activity, transferring sulfur-containing groups GO:0016782 60 52 0,000 0,02201144 0,02472221 ! regulation of cellular component size GO:0032535 66 52 0,000 0,02201144 0,0247146 ! carbohydrate transport GO:0008643 57 52 0,000 0,02201144 0,024707 ! regulation of lymphocyte proliferation GO:0050670 61 52 0,000 0,02201144 0,0246994 ! ubiquitin thiolesterase activity GO:0004221 64 52 0,000 0,02201144 0,02469181 ! nucleoside monophosphate metabolic process GO:0009123 58 52 0,000 0,02201144 0,02468421 ! cell maturation GO:0048469 68 52 0,000 0,02201144 0,02467663 ! regulation of intracellular transport GO:0032386 57 52 0,000 0,02201144 0,02466905 ! vesicle organization GO:0016050 59 52 0,000 0,02201144 0,02466147 ! kidney development GO:0001822 55 52 0,000 0,02201144 0,0246539 ! cellular component disassembly GO:0022411 69 52 0,000 0,02201144 0,02464633 ! cell redox homeostasis GO:0045454 57 52 0,000 0,02201144 0,02463877 ! lipoprotein biosynthetic process GO:0042158 57 52 0,000 0,02201144 0,02463121 ! lipid transporter activity GO:0005319 58 52 0,000 0,02201144 0,02462366 ! cytokine receptor activity GO:0004896 54 52 0,000 0,02201144 0,02461611 ! antiporter activity GO:0015297 53 52 0,000 0,02201144 0,02460857 ! embryonic limb morphogenesis GO:0030326 62 53 0,000 0,02243055 0,02506944 GO:0035113|embryonic appendage morphogenesis, ! glycosaminoglycan metabolic process GO:0030203 60 53 0,000 0,02243055 0,02506176 ! N-acetyltransferase activity GO:0008080 59 53 0,000 0,02243055 0,02505409 ! basement membrane GO:0005604 55 53 0,000 0,02243055 0,02504642 ! water-soluble vitamin metabolic process GO:0006767 59 53 0,000 0,02243055 0,02503876 ! negative regulation of response to stimulus GO:0048585 68 53 0,000 0,02243055 0,0250311 ! viral reproduction GO:0016032 59 53 0,000 0,02243055 0,02502344 ! chloride transport GO:0006821 60 53 0,000 0,02243055 0,02501579 ! oxygen and reactive oxygen species metabolic process GO:0006800 58 53 0,000 0,02243055 0,02500815 ! regulation of protein catabolic process GO:0042176 56 53 0,000 0,02243055 0,02500051 ! regulation of DNA replication GO:0006275 75 53 0,000 0,02243055 0,02499287 ! DNA catabolic process GO:0006308 57 53 0,000 0,02243055 0,02498524 ! heterocycle catabolic process GO:0046700 56 53 0,000 0,02243055 0,02497761 ! integrin-mediated signaling pathway GO:0007229 59 53 0,000 0,02243055 0,02496999 ! regulation of leukocyte proliferation GO:0070663 65 53 0,000 0,02243055 0,02496237 GO:0032944|regulation of mononuclear cell proliferation, ! single fertilization GO:0007338 58 53 0,000 0,02243055 0,02495476 ! activation of phospholipase C activity GO:0007202 61 54 0,000 0,0228495 0,02541311 GO:0010863|positive regulation of phospholipase C activity, ! double-stranded DNA binding GO:0003690 63 54 0,000 0,0228495 0,02540536 ! mitochondrial respiratory chain GO:0005746 55 54 0,000 0,0228495 0,02539762 ! nucleoside metabolic process GO:0009116 62 54 0,000 0,0228495 0,02538988 ! coated membrane GO:0048475 65 54 0,000 0,0228495 0,02538215 GO:0030117|membrane coat, ! nucleosome GO:0000786 59 54 0,000 0,0228495 0,02537443 ! regulation of protein complex assembly GO:0043254 67 54 0,000 0,0228495 0,0253667 ! cellular defense response GO:0006968 61 54 0,000 0,0228495 0,02535899 ! gastrulation GO:0007369 62 54 0,000 0,0228495 0,02535127 ! dendrite GO:0030425 60 55 0,000 0,0232683 0,02580807 ! regulation of mitosis GO:0007088 79 55 0,000 0,0232683 0,02580023 GO:0051783|regulation of nuclear division, ! positive regulation of phospholipase activity GO:0010518 62 55 0,000 0,0232683 0,02579239 ! respiratory chain GO:0070469 57 55 0,000 0,0232683 0,02578455 ! coenzyme biosynthetic process GO:0009108 68 55 0,000 0,0232683 0,02577672 ! extracellular matrix organization GO:0030198 77 55 0,000 0,0232683 0,0257689 ! positive regulation of cell motion GO:0051272 69 55 0,000 0,0232683 0,02576108 ! protein amino acid autophosphorylation GO:0046777 61 55 0,000 0,0232683 0,02575326 ! translation initiation factor activity GO:0003743 66 55 0,000 0,0232683 0,02574545 ! steroid hormone receptor signaling pathway GO:0030518 70 55 0,000 0,0232683 0,02573764 ! regulation of bone remodeling GO:0046850 64 56 0,000 0,02368693 0,02619277 ! heat shock protein binding GO:0031072 62 56 0,000 0,02368693 0,02618483 ! late endosome GO:0005770 60 56 0,000 0,02368693 0,0261769 ! regulation of phospholipase activity GO:0010517 63 56 0,000 0,02368693 0,02616897 ! sphingolipid metabolic process GO:0006665 60 56 0,000 0,02368693 0,02616105 ! intrinsic to endoplasmic reticulum membrane GO:0031227 61 56 0,000 0,02368693 0,02615313 ! ribonuclease activity GO:0004540 67 56 0,000 0,02368693 0,02614521 ! positive regulation of T cell activation GO:0050870 74 56 0,000 0,02368693 0,02613731 ! mesoderm development GO:0007498 67 56 0,000 0,02368693 0,0261294 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 61 56 0,000 0,02368693 0,0261215 ! antigen processing and presentation GO:0019882 73 56 0,000 0,02368693 0,02611361 ! proton transport GO:0015992 59 56 0,000 0,02368693 0,02610572 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 68 57 0,000 0,02410541 0,02655891 ! chromosome segregation GO:0007059 92 57 0,000 0,02410541 0,02655089 ! glycerophospholipid biosynthetic process GO:0046474 71 57 0,000 0,02410541 0,02654288 ! diacylglycerol binding GO:0019992 65 57 0,000 0,02410541 0,02653487 ! B cell activation GO:0042113 63 57 0,000 0,02410541 0,02652686 ! small ribosomal subunit GO:0015935 58 57 0,000 0,02410541 0,02651886 ! detection of external stimulus GO:0009581 64 57 0,000 0,02410541 0,02651087 ! occluding junction GO:0070160 75 58 0,000 0,02452374 0,02696281 GO:0005923|tight junction, ! hydrogen transport GO:0006818 61 58 0,000 0,02452374 0,02695468 ! receptor signaling protein serine/threonine kinase activity GO:0004702 64 58 0,000 0,02452374 0,02694656 ! lymphocyte mediated immunity GO:0002449 65 58 0,000 0,02452374 0,02693845 ! response to nutrient GO:0007584 68 58 0,000 0,02452374 0,02693034 ! large ribosomal subunit GO:0015934 64 58 0,000 0,02452374 0,02692224 ! regulation of tissue remodeling GO:0034103 66 58 0,000 0,02452374 0,02691414 ! ligand-dependent nuclear receptor activity GO:0004879 72 58 0,000 0,02452374 0,02690604 ! myosin complex GO:0016459 64 58 0,000 0,02452374 0,02689795 ! regulation of gene-specific transcription GO:0032583 69 59 0,000 0,0249419 0,02734838 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 62 59 0,000 0,0249419 0,02734016 GO:0051213|dioxygenase activity, ! muscle cell differentiation GO:0042692 77 59 0,000 0,0249419 0,02733195 ! actin filament organization GO:0007015 65 59 0,000 0,0249419 0,02732374 ! regulation of heart contraction GO:0008016 71 59 0,000 0,0249419 0,02731554 ! hexose catabolic process GO:0019320 64 59 0,000 0,0249419 0,02730734 ! cellular amino acid catabolic process GO:0009063 63 59 0,000 0,0249419 0,02729915 ! response to steroid hormone stimulus GO:0048545 74 59 0,000 0,0249419 0,02729096 ! cell projection assembly GO:0030031 79 59 0,000 0,0249419 0,02728278 ! regulation of cellular response to stress GO:0080135 79 59 0,000 0,0249419 0,0272746 ! appendage morphogenesis GO:0035107 68 59 0,000 0,0249419 0,02726642 GO:0035108|limb morphogenesis, ! homeostasis of number of cells GO:0048872 67 59 0,000 0,0249419 0,02725826 ! fertilization GO:0009566 65 59 0,000 0,0249419 0,02725009 ! DNA-directed RNA polymerase II, holoenzyme GO:0016591 62 59 0,000 0,0249419 0,02724193 ! Rho guanyl-nucleotide exchange factor activity GO:0005089 69 59 0,000 0,0249419 0,02723378 ! adult behavior GO:0030534 72 59 0,000 0,0249419 0,02722563 ! organelle localization GO:0051640 70 59 0,000 0,0249419 0,02721749 ! positive regulation of secretion GO:0051047 66 60 0,000 0,02535991 0,02766536 ! molecular adaptor activity GO:0060090 73 60 0,000 0,02535991 0,02765709 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GO:0016701 63 60 0,000 0,02535991 0,02764882 ! phosphoinositide metabolic process GO:0030384 68 60 0,000 0,02535991 0,02764056 ! copper ion binding GO:0005507 85 60 0,000 0,02535991 0,0276323 ! positive regulation of lipase activity GO:0060193 68 60 0,000 0,02535991 0,02762405 ! activation of immune response GO:0002253 72 60 0,000 0,02535991 0,02761581 ! cell cycle checkpoint GO:0000075 91 60 0,000 0,02535991 0,02760757 ! appendage development GO:0048736 69 60 0,000 0,02535991 0,02759933 GO:0060173|limb development, ! regulation of vesicle-mediated transport GO:0060627 69 60 0,000 0,02535991 0,0275911 ! secondary metabolic process GO:0019748 67 60 0,000 0,02535991 0,02758287 ! cellular hormone metabolic process GO:0034754 64 61 0,000 0,02577776 0,028029 ! ear development GO:0043583 76 61 0,000 0,02577776 0,02802064 ! ATPase activity, coupled to transmembrane movement of ions GO:0042625 68 61 0,000 0,02577776 0,0280123 ! learning or memory GO:0007611 79 61 0,000 0,02577776 0,02800395 ! Ras GTPase binding GO:0017016 78 61 0,000 0,02577776 0,02799562 ! camera-type eye development GO:0043010 69 61 0,000 0,02577776 0,02798729 ! transcription initiation from RNA polymerase II promoter GO:0006367 69 61 0,000 0,02577776 0,02797896 ! regulation of transcription factor activity GO:0051090 80 62 0,000 0,02619546 0,02842386 GO:0090046|regulation of transcription regulator activity, ! lung development GO:0030324 90 62 0,000 0,02619546 0,02841541 ! lysosomal membrane GO:0005765 69 62 0,000 0,02619546 0,02840697 ! membrane lipid metabolic process GO:0006643 76 62 0,000 0,02619546 0,02839852 ! nuclear pore GO:0005643 79 62 0,000 0,02619546 0,02839009 ! transmembrane receptor protein tyrosine kinase activity GO:0004714 77 62 0,000 0,02619546 0,02838166 ! skeletal system morphogenesis GO:0048705 83 62 0,000 0,02619546 0,02837323 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 77 62 0,000 0,02619546 0,02836481 ! chloride channel activity GO:0005254 72 62 0,000 0,02619546 0,02835639 ! cell soma GO:0043025 68 62 0,000 0,02619546 0,02834798 ! microtubule motor activity GO:0003777 94 62 0,000 0,02619546 0,02833957 ! intracellular receptor-mediated signaling pathway GO:0030522 80 62 0,000 0,02619546 0,02833117 ! focal adhesion GO:0005925 72 62 0,000 0,02619546 0,02832277 ! protein maturation by peptide bond cleavage GO:0051605 69 62 0,000 0,02619546 0,02831438 ! negative regulation of cell growth GO:0030308 69 63 0,000 0,026613 0,02875717 ! FAD binding GO:0050660 71 63 0,000 0,026613 0,02874866 ! urogenital system development GO:0001655 75 63 0,000 0,026613 0,02874015 ! regulation of synaptic transmission GO:0050804 79 63 0,000 0,026613 0,02873164 ! aminoglycan metabolic process GO:0006022 70 63 0,000 0,026613 0,02872314 ! cAMP-mediated signaling GO:0019933 75 63 0,000 0,026613 0,02871464 ! amine transmembrane transporter activity GO:0005275 69 63 0,000 0,026613 0,02870615 ! regulation of immune effector process GO:0002697 81 63 0,000 0,026613 0,02869767 ! respiratory tube development GO:0030323 92 64 0,000 0,02703038 0,02913913 ! intracellular protein transmembrane transport GO:0065002 83 64 0,000 0,02703038 0,02913052 ! tRNA processing GO:0008033 73 64 0,000 0,02703038 0,02912192 ! negative regulation of ligase activity GO:0051352 79 64 0,000 0,02703038 0,02911332 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! regulation of myeloid cell differentiation GO:0045637 77 64 0,000 0,02703038 0,02910473 ! adaptive immune response GO:0002250 70 64 0,000 0,02703038 0,02909614 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! transition metal ion transport GO:0000041 74 64 0,000 0,02703038 0,02908756 ! neurotransmitter transport GO:0006836 72 64 0,000 0,02703038 0,02907898 ! nuclear hormone receptor binding GO:0035257 79 64 0,000 0,02703038 0,02907041 ! N-acyltransferase activity GO:0016410 70 64 0,000 0,02703038 0,02906184 ! negative regulation of cell size GO:0045792 71 65 0,000 0,0274476 0,02950173 ! multicellular organism reproduction GO:0032504 71 65 0,000 0,0274476 0,02949304 GO:0048609|reproductive process in a multicellular organism, ! lymphocyte differentiation GO:0030098 93 65 0,000 0,0274476 0,02948435 ! positive regulation of lymphocyte activation GO:0051251 83 65 0,000 0,0274476 0,02947567 ! regulation of cytokine biosynthetic process GO:0042035 84 65 0,000 0,0274476 0,029467 ! activation of MAPK activity GO:0000187 74 65 0,000 0,0274476 0,02945833 ! gonad development GO:0008406 71 65 0,000 0,0274476 0,02944967 ! acetyltransferase activity GO:0016407 73 65 0,000 0,0274476 0,02944101 ! protein import into nucleus GO:0006606 73 66 0,000 0,02786467 0,02987958 ! developmental maturation GO:0021700 85 66 0,000 0,02786467 0,0298708 ! myeloid cell differentiation GO:0030099 78 66 0,000 0,02786467 0,02986202 ! tubulin binding GO:0015631 92 66 0,000 0,02786467 0,02985325 ! leukocyte mediated immunity GO:0002443 73 66 0,000 0,02786467 0,02984449 ! tube morphogenesis GO:0035239 84 66 0,000 0,02786467 0,02983573 ! cysteine-type endopeptidase activity GO:0004197 73 66 0,000 0,02786467 0,02982697 ! cell-substrate adherens junction GO:0005924 76 66 0,000 0,02786467 0,02981822 ! endoplasmic reticulum lumen GO:0005788 78 67 0,000 0,02828159 0,03025549 ! glycerolipid biosynthetic process GO:0045017 81 67 0,000 0,02828159 0,03024662 ! nuclear import GO:0051170 74 67 0,000 0,02828159 0,03023776 ! activation of protein kinase activity GO:0032147 83 67 0,000 0,02828159 0,0302289 ! chloride ion binding GO:0031404 79 67 0,000 0,02828159 0,03022004 ! humoral immune response GO:0006959 75 67 0,000 0,02828159 0,03021119 ! amine binding GO:0043176 77 67 0,000 0,02828159 0,03020235 ! female pregnancy GO:0007565 78 67 0,000 0,02828159 0,03019351 ! extrinsic to membrane GO:0019898 75 67 0,000 0,02828159 0,03018468 ! anion channel activity GO:0005253 77 67 0,000 0,02828159 0,03017585 ! regulation of homeostatic process GO:0032844 88 67 0,000 0,02828159 0,03016702 ! regulation of adenylate cyclase activity GO:0045761 81 68 0,000 0,02869834 0,03060262 ! amine catabolic process GO:0009310 73 68 0,000 0,02869834 0,03059367 ! monosaccharide catabolic process GO:0046365 73 68 0,000 0,02869834 0,03058474 ! cell-substrate junction GO:0030055 78 68 0,000 0,02869834 0,0305758 ! respiratory system development GO:0060541 96 68 0,000 0,02869834 0,03056688 ! mRNA transport GO:0051028 88 69 0,000 0,02911494 0,03100155 ! fatty acid biosynthetic process GO:0006633 76 69 0,000 0,02911494 0,0309925 ! small GTPase binding GO:0031267 86 69 0,000 0,02911494 0,03098346 ! regulation of transmission of nerve impulse GO:0051969 87 69 0,000 0,02911494 0,03097443 ! sarcomere GO:0030017 74 69 0,000 0,02911494 0,0309654 ! exocytosis GO:0006887 76 69 0,000 0,02911494 0,03095637 ! skeletal muscle tissue development GO:0007519 75 69 0,000 0,02911494 0,03094735 GO:0060538|skeletal muscle organ development, ! nucleosome assembly GO:0006334 87 69 0,000 0,02911494 0,03093834 ! extracellular ligand-gated ion channel activity GO:0005230 82 69 0,000 0,02911494 0,03092933 ! Ras guanyl-nucleotide exchange factor activity GO:0005088 79 69 0,000 0,02911494 0,03092032 ! amine biosynthetic process GO:0009309 78 70 0,000 0,02953138 0,03135346 ! thiolester hydrolase activity GO:0016790 84 70 0,000 0,02953138 0,03134434 ! early endosome GO:0005769 104 70 0,000 0,02953138 0,03133522 ! regulation of cyclase activity GO:0031279 83 70 0,000 0,02953138 0,03132611 ! regulation of lipase activity GO:0060191 78 70 0,000 0,02953138 0,031317 ! amino acid transport GO:0006865 76 70 0,000 0,02953138 0,0313079 ! chromatin assembly GO:0031497 88 70 0,000 0,02953138 0,03129881 ! hormone receptor binding GO:0051427 85 70 0,000 0,02953138 0,03128972 ! calcium channel activity GO:0005262 86 70 0,000 0,02953138 0,03128063 ! axon guidance GO:0007411 87 70 0,000 0,02953138 0,03127155 ! nuclear chromosome part GO:0044454 94 70 0,000 0,02953138 0,03126248 ! oxidoreductase activity, acting on NADH or NADPH GO:0016651 73 71 0,000 0,02994767 0,03169397 ! mitochondrial outer membrane GO:0005741 81 71 0,000 0,02994767 0,03168477 ! protein localization in nucleus GO:0034504 78 71 0,000 0,02994767 0,03167559 ! lipoprotein metabolic process GO:0042157 76 71 0,000 0,02994767 0,03166641 ! pore complex GO:0046930 89 72 0,000 0,0303638 0,03209712 ! response to hypoxia GO:0001666 84 72 0,000 0,0303638 0,03208782 ! steroid biosynthetic process GO:0006694 83 72 0,000 0,0303638 0,03207853 ! regulation of MAPKKK cascade GO:0043408 82 72 0,000 0,0303638 0,03206924 ! regulation of lyase activity GO:0051339 85 72 0,000 0,0303638 0,03205996 ! acute inflammatory response GO:0002526 91 72 0,000 0,0303638 0,03205068 ! apical junction complex GO:0043296 90 72 0,000 0,0303638 0,03204141 ! phospholipase activity GO:0004620 99 72 0,000 0,0303638 0,03203214 ! membrane raft GO:0045121 81 72 0,000 0,0303638 0,03202288 ! regulation of neurological system process GO:0031644 91 72 0,000 0,0303638 0,03201363 ! structural constituent of cytoskeleton GO:0005200 78 72 0,000 0,0303638 0,03200438 ! elevation of cytosolic calcium ion concentration GO:0007204 87 73 0,000 0,03077978 0,03243346 GO:0051480|cytosolic calcium ion homeostasis, ! response to drug GO:0042493 94 73 0,000 0,03077978 0,03242409 ! protein transporter activity GO:0008565 80 73 0,000 0,03077978 0,03241473 ! regulation of cAMP biosynthetic process GO:0030817 86 73 0,000 0,03077978 0,03240537 ! exopeptidase activity GO:0008238 81 73 0,000 0,03077978 0,03239603 ! digestion GO:0007586 81 73 0,000 0,03077978 0,03238668 ! positive regulation of leukocyte activation GO:0002696 92 73 0,000 0,03077978 0,03237734 ! cell-matrix adhesion GO:0007160 102 74 0,000 0,03119559 0,03280528 ! response to oxygen levels GO:0070482 86 74 0,000 0,03119559 0,03279583 ! potassium channel complex GO:0034705 84 74 0,000 0,03119559 0,03278638 GO:0008076|voltage-gated potassium channel complex, ! GTPase binding GO:0051020 91 74 0,000 0,03119559 0,03277694 ! protein-DNA complex assembly GO:0065004 101 74 0,000 0,03119559 0,0327675 ! hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 85 74 0,000 0,03119559 0,03275807 ! one-carbon metabolic process GO:0006730 84 74 0,000 0,03119559 0,03274864 ! blood coagulation GO:0007596 90 74 0,000 0,03119559 0,03273922 GO:0050817|coagulation, ! reproductive structure development GO:0048608 89 74 0,000 0,03119559 0,0327298 ! apicolateral plasma membrane GO:0016327 92 74 0,000 0,03119559 0,03272039 ! phosphoinositide-mediated signaling GO:0048015 92 74 0,000 0,03119559 0,03271099 ! cellular lipid catabolic process GO:0044242 99 74 0,000 0,03119559 0,03270159 ! ubiquitin ligase complex GO:0000151 91 74 0,000 0,03119559 0,03269219 ! cell projection part GO:0044463 80 74 0,000 0,03119559 0,03268281 ! meiosis GO:0007126 108 75 0,000 0,03161126 0,03310877 GO:0051327|M phase of meiotic cell cycle, ! regulation of DNA binding GO:0051101 94 75 0,000 0,03161126 0,03309927 ! carboxylic acid transmembrane transporter activity GO:0046943 85 75 0,000 0,03161126 0,03308977 ! regulation of cell cycle process GO:0010564 113 75 0,000 0,03161126 0,03308028 ! positive regulation of cell activation GO:0050867 94 75 0,000 0,03161126 0,0330708 ! regulation of cAMP metabolic process GO:0030814 88 75 0,000 0,03161126 0,03306131 ! regulation of blood pressure GO:0008217 82 75 0,000 0,03161126 0,03305184 ! transcription initiation GO:0006352 84 75 0,000 0,03161126 0,03304237 ! Ras GTPase activator activity GO:0005099 83 75 0,000 0,03161126 0,0330329 ! neuropeptide signaling pathway GO:0007218 85 76 0,000 0,03202676 0,03345751 ! negative regulation of growth GO:0045926 85 76 0,000 0,03202676 0,03344793 ! defense response to bacterium GO:0042742 81 76 0,000 0,03202676 0,03343836 ! regulation of lipid metabolic process GO:0019216 98 76 0,000 0,03202676 0,03342879 ! meiotic cell cycle GO:0051321 109 76 0,000 0,03202676 0,03341923 ! regulation of neuron differentiation GO:0045664 96 76 0,000 0,03202676 0,03340967 ! condensed chromosome GO:0000793 106 76 0,000 0,03202676 0,03340012 ! protein-DNA complex GO:0032993 93 76 0,000 0,03202676 0,03339058 ! organic acid transmembrane transporter activity GO:0005342 86 76 0,000 0,03202676 0,03338104 ! development of primary sexual characteristics GO:0045137 86 76 0,000 0,03202676 0,0333715 ! cytosolic ribosome GO:0022626 82 76 0,000 0,03202676 0,03336197 ! serine-type endopeptidase inhibitor activity GO:0004867 93 76 0,000 0,03202676 0,03335245 ! S-adenosylmethionine-dependent methyltransferase activity GO:0008757 84 77 0,000 0,03244211 0,03377535 ! nucleosome organization GO:0034728 96 77 0,000 0,03244211 0,03376571 ! alcohol catabolic process GO:0046164 84 77 0,000 0,03244211 0,03375608 ! vacuolar membrane GO:0005774 86 77 0,000 0,03244211 0,03374646 ! G-protein-coupled receptor binding GO:0001664 87 77 0,000 0,03244211 0,03373684 ! myofibril GO:0030016 82 77 0,000 0,03244211 0,03372722 ! protein oligomerization GO:0051259 93 77 0,000 0,03244211 0,03371761 ! phosphoric diester hydrolase activity GO:0008081 99 78 0,000 0,03285731 0,03413941 ! endonuclease activity GO:0004519 111 78 0,000 0,03285731 0,03412969 ! cofactor biosynthetic process GO:0051188 93 78 0,000 0,03285731 0,03411997 ! inorganic anion transport GO:0015698 87 78 0,000 0,03285731 0,03411026 ! regulation of protein transport GO:0051223 85 78 0,000 0,03285731 0,03410056 ! regulation of nucleotide biosynthetic process GO:0030808 91 78 0,000 0,03285731 0,03409086 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! transmembrane receptor protein kinase activity GO:0019199 95 78 0,000 0,03285731 0,03408116 ! carboxylesterase activity GO:0004091 93 78 0,000 0,03285731 0,03407148 ! protein ubiquitination GO:0016567 95 78 0,000 0,03285731 0,03406179 ! extracellular matrix structural constituent GO:0005201 96 78 0,000 0,03285731 0,03405212 ! contractile fiber part GO:0044449 83 78 0,000 0,03285731 0,03404245 ! positive regulation of MAP kinase activity GO:0043406 89 79 0,000 0,03327234 0,03446267 ! vitamin metabolic process GO:0006766 86 79 0,000 0,03327234 0,03445288 ! T cell activation GO:0042110 120 79 0,000 0,03327234 0,03444311 ! cellular response to hormone stimulus GO:0032870 94 79 0,000 0,03327234 0,03443334 ! phosphoinositide binding GO:0035091 99 79 0,000 0,03327234 0,03442357 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 88 80 0,000 0,03368723 0,03484293 ! eye development GO:0001654 93 80 0,000 0,03368723 0,03483305 ! ATP biosynthetic process GO:0006754 89 80 0,000 0,03368723 0,03482318 ! rhythmic process GO:0048511 90 80 0,000 0,03368723 0,03481332 ! regulation of catabolic process GO:0009894 87 80 0,000 0,03368723 0,03480346 ! SH3 domain binding GO:0017124 95 80 0,000 0,03368723 0,0347936 ! hemostasis GO:0007599 96 80 0,000 0,03368723 0,03478375 ! chromosome, centromeric region GO:0000775 119 80 0,000 0,03368723 0,03477391 ! regulation of cyclic nucleotide metabolic process GO:0030799 93 80 0,000 0,03368723 0,03476407 ! cell-substrate adhesion GO:0031589 109 80 0,000 0,03368723 0,03475424 ! rRNA processing GO:0006364 84 80 0,000 0,03368723 0,03474442 ! cholesterol metabolic process GO:0008203 91 81 0,000 0,03410195 0,03516222 ! vacuolar part GO:0044437 91 81 0,000 0,03410195 0,03515228 ! ossification GO:0001503 111 82 0,000 0,03451652 0,03556957 ! biogenic amine metabolic process GO:0006576 99 82 0,000 0,03451652 0,03555953 ! forebrain development GO:0030900 93 82 0,000 0,03451652 0,03554949 ! external side of plasma membrane GO:0009897 105 82 0,000 0,03451652 0,03553945 ! cellular respiration GO:0045333 85 82 0,000 0,03451652 0,03552942 ! heparin binding GO:0008201 108 82 0,000 0,03451652 0,0355194 ! microtubule-based movement GO:0007018 119 83 0,000 0,03493094 0,03593572 ! nuclear speck GO:0016607 99 83 0,000 0,03493094 0,03592559 ! rRNA metabolic process GO:0016072 88 83 0,000 0,03493094 0,03591546 ! ATP-dependent helicase activity GO:0008026 107 83 0,000 0,03493094 0,03590534 GO:0070035|purine NTP-dependent helicase activity, ! regulation of T cell activation GO:0050863 104 83 0,000 0,03493094 0,03589523 ! regulation of establishment of protein localization GO:0070201 90 83 0,000 0,03493094 0,03588512 ! oxidative phosphorylation GO:0006119 85 83 0,000 0,03493094 0,03587502 ! contractile fiber GO:0043292 88 83 0,000 0,03493094 0,03586492 ! bone development GO:0060348 112 83 0,000 0,03493094 0,03585483 ! regulation of nucleotide metabolic process GO:0006140 96 83 0,000 0,03493094 0,03584474 ! regulation of membrane potential GO:0042391 98 83 0,000 0,03493094 0,03583466 ! cilium GO:0005929 88 83 0,000 0,03493094 0,03582459 ! regulation of DNA metabolic process GO:0051052 139 84 0,000 0,0353452 0,03623926 ! regulation of defense response GO:0031347 98 84 0,000 0,0353452 0,03622908 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 94 84 0,000 0,0353452 0,0362189 ! nitrogen compound catabolic process GO:0044270 91 84 0,000 0,0353452 0,03620873 ! DNA recombination GO:0006310 147 84 0,000 0,0353452 0,03619856 ! phospholipid biosynthetic process GO:0008654 101 85 0,000 0,0357593 0,03661239 ! protein modification by small protein conjugation GO:0032446 103 85 0,000 0,0357593 0,03660211 ! monooxygenase activity GO:0004497 92 85 0,000 0,0357593 0,03659185 ! hydrogen ion transmembrane transporter activity GO:0015078 88 85 0,000 0,0357593 0,03658159 ! protein binding, bridging GO:0030674 104 85 0,000 0,0357593 0,03657133 ! negative regulation of transport GO:0051051 98 86 0,000 0,03617325 0,03698431 ! clathrin-coated vesicle GO:0030136 100 86 0,000 0,03617325 0,03697395 ! Golgi vesicle transport GO:0048193 98 86 0,000 0,03617325 0,03696359 ! lipase activity GO:0016298 114 86 0,000 0,03617325 0,03695324 ! voltage-gated potassium channel activity GO:0005249 105 86 0,000 0,03617325 0,03694289 ! adherens junction GO:0005912 100 86 0,000 0,03617325 0,03693255 ! microtubule cytoskeleton organization GO:0000226 113 87 0,000 0,03658704 0,03734458 ! leukocyte differentiation GO:0002521 118 87 0,000 0,03658704 0,03733414 ! pigment granule GO:0048770 101 87 0,000 0,03658704 0,0373237 GO:0042470|melanosome, ! regulation of cell morphogenesis GO:0022604 100 87 0,000 0,03658704 0,03731326 ! organelle outer membrane GO:0031968 102 88 0,000 0,03700068 0,03772456 ! carbohydrate biosynthetic process GO:0016051 95 88 0,000 0,03700068 0,03771402 ! growth factor binding GO:0019838 102 88 0,000 0,03700068 0,03770349 ! protein processing GO:0016485 100 88 0,000 0,03700068 0,03769296 ! gland development GO:0048732 108 89 0,000 0,03741416 0,03810354 ! ATP metabolic process GO:0046034 100 90 0,000 0,03782749 0,03851373 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 101 90 0,000 0,03782749 0,03850298 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! peroxisome GO:0005777 100 90 0,000 0,03782749 0,03849224 GO:0042579|microbody, ! glycerophospholipid metabolic process GO:0006650 109 90 0,000 0,03782749 0,03848151 ! sterol metabolic process GO:0016125 102 90 0,000 0,03782749 0,03847078 ! negative regulation of multicellular organismal process GO:0051241 102 90 0,000 0,03782749 0,03846006 ! anion binding GO:0043168 104 90 0,000 0,03782749 0,03844934 ! amine transport GO:0015837 97 90 0,000 0,03782749 0,03843863 ! response to virus GO:0009615 109 90 0,000 0,03782749 0,03842793 ! outer membrane GO:0019867 104 90 0,000 0,03782749 0,03841723 ! extracellular matrix part GO:0044420 111 90 0,000 0,03782749 0,03840654 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 108 91 0,000 0,03824066 0,03881523 ! ribonucleoside triphosphate biosynthetic process GO:0009201 102 91 0,000 0,03824066 0,03880443 GO:0009142|nucleoside triphosphate biosynthetic process, ! positive regulation of immune response GO:0050778 104 91 0,000 0,03824066 0,03879364 ! sulfur metabolic process GO:0006790 98 91 0,000 0,03824066 0,03878285 ! sex differentiation GO:0007548 103 91 0,000 0,03824066 0,03877208 ! hormone metabolic process GO:0042445 107 91 0,000 0,03824066 0,0387613 ! regulation of protein localization GO:0032880 99 91 0,000 0,03824066 0,03875054 ! detection of stimulus GO:0051606 100 91 0,000 0,03824066 0,03873977 ! structure-specific DNA binding GO:0043566 112 92 0,000 0,03865368 0,03914731 ! anatomical structure homeostasis GO:0060249 121 92 0,000 0,03865368 0,03913644 ! carboxylic acid catabolic process GO:0046395 100 92 0,000 0,03865368 0,03912559 GO:0016054|organic acid catabolic process, ! translation factor activity, nucleic acid binding GO:0008135 108 92 0,000 0,03865368 0,03911473 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 111 92 0,000 0,03865368 0,03910389 ! extracellular structure organization GO:0043062 119 92 0,000 0,03865368 0,03909304 ! protein import GO:0017038 102 93 0,000 0,03906654 0,03949965 ! neurotransmitter receptor activity GO:0030594 104 93 0,000 0,03906654 0,0394887 ! response to nutrient levels GO:0031667 105 93 0,000 0,03906654 0,03947776 ! Ras protein signal transduction GO:0007265 118 93 0,000 0,03906654 0,03946683 ! protein modification by small protein conjugation or removal GO:0070647 112 93 0,000 0,03906654 0,0394559 ! ATPase activity, coupled to transmembrane movement of substances GO:0042626 102 94 0,000 0,03947924 0,03986169 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 104 94 0,000 0,03947924 0,03985066 ! morphogenesis of an epithelium GO:0002009 113 94 0,000 0,03947924 0,03983963 GO:0060429|epithelium development, ! anchoring junction GO:0070161 108 94 0,000 0,03947924 0,03982862 ! neurotransmitter binding GO:0042165 105 94 0,000 0,03947924 0,03981761 ! DNA packaging GO:0006323 113 94 0,000 0,03947924 0,0398066 ! homophilic cell adhesion GO:0007156 107 95 0,000 0,03989179 0,04021146 ! ATPase activity, coupled to movement of substances GO:0043492 104 95 0,000 0,03989179 0,04020035 ! anterior/posterior pattern formation GO:0009952 109 95 0,000 0,03989179 0,04018925 ! protein localization in organelle GO:0033365 104 95 0,000 0,03989179 0,04017815 ! Wnt receptor signaling pathway GO:0016055 121 95 0,000 0,03989179 0,04016706 ! immune effector process GO:0002252 110 95 0,000 0,03989179 0,04015598 ! apical plasma membrane GO:0016324 105 95 0,000 0,03989179 0,0401449 ! translational elongation GO:0006414 104 96 0,000 0,04030419 0,04054873 ! hydrolase activity, acting on glycosyl bonds GO:0016798 109 96 0,000 0,04030419 0,04053755 ! in utero embryonic development GO:0001701 110 96 0,000 0,04030419 0,04052637 ! carbohydrate catabolic process GO:0016052 116 96 0,000 0,04030419 0,04051521 ! receptor complex GO:0043235 131 96 0,000 0,04030419 0,04050404 ! regulation of response to external stimulus GO:0032101 109 96 0,000 0,04030419 0,04049289 ! monovalent inorganic cation transmembrane transporter activity GO:0015077 100 96 0,000 0,04030419 0,04048174 ! electron transport chain GO:0022900 104 97 0,000 0,04071643 0,04088454 ! metalloendopeptidase activity GO:0004222 126 97 0,000 0,04071643 0,04087329 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016820 105 97 0,000 0,04071643 0,04086205 ! carboxylic acid binding GO:0031406 108 97 0,000 0,04071643 0,04085081 ! protein maturation GO:0051604 109 97 0,000 0,04071643 0,04083957 ! intermediate filament GO:0005882 102 98 0,000 0,04112851 0,04124157 GO:0045111|intermediate filament cytoskeleton, ! UDP-glycosyltransferase activity GO:0008194 120 98 0,000 0,04112851 0,04123023 ! cell fate commitment GO:0045165 118 98 0,000 0,04112851 0,04121891 ! hormone activity GO:0005179 113 99 0,000 0,04154045 0,04162031 ! solute:cation symporter activity GO:0015294 110 99 0,000 0,04154045 0,04160888 ! unfolded protein binding GO:0051082 118 100 0,000 0,04195222 0,0420098 ! nuclear chromosome GO:0000228 127 100 0,000 0,04195222 0,04199827 ! regulation of neurogenesis GO:0050767 123 100 0,000 0,04195222 0,04198675 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016810 105 100 0,000 0,04195222 0,04197523 ! regulation of lymphocyte activation GO:0051249 123 100 0,000 0,04195222 0,04196372 ! peptide receptor activity, G-protein coupled GO:0008528 107 100 0,000 0,04195222 0,04195222