pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a2/out-0.05-06-0.01-300-run-a2//th1-pval-1e-01-11-th2-pval-1e-02-02-th3-pval-1e-01-02-run-a2/go_data/6698-8-real-Zhou-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/GPL4685_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! keratinocyte differentiation GO:0030216 55 37 5,000 9,903E-12 2,35E-08 ! epidermal cell differentiation GO:0009913 61 42 5,000 2,224E-11 2,639E-08 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 1,393E-07 1,102E-04 ! induction of apoptosis by intracellular signals GO:0008629 78 42 3,000 3,39E-07 2,011E-04 ! regulation of B cell proliferation GO:0030888 24 13 2,000 7,08E-07 3,36E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 86 53 3,000 8,775E-07 3,471E-04 ! negative regulation of caspase activity GO:0043154 22 14 2,000 9,003E-07 3,052E-04 ! release of cytochrome c from mitochondria GO:0001836 29 15 2,000 1,124E-06 3,335E-04 ! negative regulation of protein kinase activity GO:0006469 110 62 3,000 1,657E-06 4,37E-04 ! negative regulation of peptidase activity GO:0010466 25 17 2,000 1,677E-06 3,98E-04 ! negative regulation of kinase activity GO:0033673 112 63 3,000 1,768E-06 3,814E-04 ! keratinization GO:0031424 19 18 2,000 2,011E-06 3,976E-04 ! negative regulation of transferase activity GO:0051348 117 66 3,000 2,133E-06 3,893E-04 ! peptide cross-linking GO:0018149 35 19 2,000 2,385E-06 4,043E-04 ! G2/M transition of mitotic cell cycle GO:0000086 34 21 2,000 3,268E-06 5,17E-04 ! apoptotic mitochondrial changes GO:0008637 42 21 2,000 3,268E-06 4,847E-04 ! epidermal growth factor receptor signaling pathway GO:0007173 42 26 2,000 6,358E-06 8,875E-04 ! regulation of B cell activation GO:0050864 55 33 2,000 1,325E-05 1,747E-03 ! negative regulation of hydrolase activity GO:0051346 56 35 2,000 1,587E-05 1,982E-03 ! negative regulation of protein ubiquitination GO:0031397 7 5 1,000 1,906E-05 2,262E-03 ! skeletal myofibril assembly GO:0014866 8 5 1,000 1,906E-05 2,154E-03 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 1,906E-05 2,056E-03 ! B cell homeostasis GO:0001782 12 5 1,000 1,906E-05 1,967E-03 ! establishment of apical/basal cell polarity GO:0035089 7 5 1,000 1,906E-05 1,885E-03 ! striated muscle cell differentiation GO:0051146 58 39 2,000 2,208E-05 2,096E-03 ! positive regulation of Rho GTPase activity GO:0032321 12 6 1,000 2,857E-05 2,608E-03 ! establishment of chromosome localization GO:0051303 10 6 1,000 2,857E-05 2,511E-03 GO:0050000|chromosome localization, ! regulation of Rac protein signal transduction GO:0035020 9 6 1,000 2,857E-05 2,421E-03 ! response to insulin stimulus GO:0032868 71 45 2,000 3,409E-05 2,789E-03 ! response to UV GO:0009411 79 47 2,000 3,888E-05 3,075E-03 ! positive regulation of mitotic cell cycle GO:0045931 13 7 1,000 3,997E-05 3,059E-03 ! spindle checkpoint GO:0031577 20 7 1,000 3,997E-05 2,964E-03 ! eye photoreceptor cell differentiation GO:0001754 14 7 1,000 3,997E-05 2,874E-03 GO:0042462|eye photoreceptor cell development, ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 1,000 3,997E-05 2,789E-03 ! regulation of mast cell proliferation GO:0070666 80 50 2,000 4,686E-05 3,177E-03 ! positive regulation of small GTPase mediated signal transduction GO:0051057 16 8 1,000 5,324E-05 3,509E-03 GO:0046579|positive regulation of Ras protein signal transduction, ! keratinocyte proliferation GO:0043616 15 8 1,000 5,324E-05 3,415E-03 ! regulation of focal adhesion formation GO:0051893 17 8 1,000 5,324E-05 3,325E-03 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 1,000 5,324E-05 3,24E-03 ! negative regulation of B cell activation GO:0050869 17 8 1,000 5,324E-05 3,159E-03 ! regulation of leukocyte proliferation GO:0070663 88 53 2,000 5,585E-05 3,232E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! photoreceptor cell development GO:0042461 17 9 1,000 6,839E-05 3,864E-03 GO:0046530|photoreceptor cell differentiation, ! regulation of exit from mitosis GO:0007096 12 9 1,000 6,839E-05 3,774E-03 ! neuron apoptosis GO:0051402 12 9 1,000 6,839E-05 3,689E-03 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 16 9 1,000 6,839E-05 3,607E-03 ! response to peptide hormone stimulus GO:0043434 97 60 2,000 8,105E-05 4,181E-03 ! positive regulation of B cell proliferation GO:0030890 14 10 1,000 8,542E-05 4,313E-03 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 8,542E-05 4,223E-03 ! regulation of activated T cell proliferation GO:0046006 22 10 1,000 8,542E-05 4,137E-03 ! regulation of phosphoprotein phosphatase activity GO:0043666 20 10 1,000 8,542E-05 4,054E-03 ! regulation of stress fiber formation GO:0051492 24 10 1,000 8,542E-05 3,974E-03 ! positive regulation of Ras GTPase activity GO:0032320 24 10 1,000 8,542E-05 3,898E-03 ! establishment of cell polarity GO:0030010 12 10 1,000 8,542E-05 3,824E-03 ! actin filament organization GO:0007015 107 64 2,000 9,83E-05 4,32E-03 ! regulation of phosphatase activity GO:0010921 23 11 1,000 1,043E-04 4,5E-03 ! Golgi vesicle budding GO:0048194 18 11 1,000 1,043E-04 4,42E-03 ! regulation of actin filament bundle formation GO:0032231 25 11 1,000 1,043E-04 4,342E-03 ! regulation of caspase activity GO:0043281 104 68 2,000 1,178E-04 4,82E-03 ! positive regulation of GTPase activity GO:0043547 29 12 1,000 1,251E-04 5,03E-03 ! regulation of Rho GTPase activity GO:0032319 22 12 1,000 1,251E-04 4,946E-03 ! T cell homeostasis GO:0043029 22 12 1,000 1,251E-04 4,865E-03 ! establishment or maintenance of apical/basal cell polarity GO:0035088 23 12 1,000 1,251E-04 4,787E-03 ! regulation of endopeptidase activity GO:0052548 106 70 2,000 1,284E-04 4,837E-03 ! regulation of peptidase activity GO:0052547 113 75 2,000 1,577E-04 5,846E-03 ! regulation of protein ubiquitination GO:0031396 20 14 1,000 1,721E-04 6,284E-03 ! negative regulation of mast cell proliferation GO:0070667 26 14 1,000 1,721E-04 6,189E-03 GO:0042130|negative regulation of T cell proliferation, ! muscle cell differentiation GO:0042692 117 78 2,000 1,771E-04 6,274E-03 ! mitochondrion organization GO:0007005 127 78 2,000 1,771E-04 6,182E-03 ! skin development GO:0043588 28 15 1,000 1,984E-04 6,825E-03 ! induction of apoptosis via death domain receptors GO:0008625 19 15 1,000 1,984E-04 6,727E-03 ! activation of NF-kappaB-inducing kinase activity GO:0007250 23 15 1,000 1,984E-04 6,632E-03 ! lymphocyte homeostasis GO:0002260 29 15 1,000 1,984E-04 6,54E-03 ! positive regulation of cell growth GO:0030307 22 16 1,000 2,266E-04 7,366E-03 ! DNA fragmentation involved in apoptosis GO:0006309 20 16 1,000 2,266E-04 7,266E-03 ! interphase of mitotic cell cycle GO:0051329 166 87 2,000 2,447E-04 7,743E-03 ! membrane budding GO:0006900 30 17 1,000 2,566E-04 8,011E-03 ! interphase GO:0051325 169 89 2,000 2,617E-04 8,066E-03 ! transcription from RNA polymerase III promoter GO:0006383 36 18 1,000 2,884E-04 8,774E-03 ! regulation of dephosphorylation GO:0035303 38 18 1,000 2,884E-04 8,663E-03 ! cell-cell junction organization GO:0045216 28 18 1,000 2,884E-04 8,555E-03 ! negative regulation of leukocyte proliferation GO:0070664 35 18 1,000 2,884E-04 8,449E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of cell size GO:0045793 26 19 1,000 3,22E-04 9,32E-03 ! regulation of neuronal synaptic plasticity GO:0048168 37 19 1,000 3,22E-04 9,208E-03 ! response to lipopolysaccharide GO:0032496 28 19 1,000 3,22E-04 9,098E-03 ! cell structure disassembly during apoptosis GO:0006921 25 20 1,000 3,575E-04 9,981E-03 ! negative regulation of translation GO:0017148 28 20 1,000 3,575E-04 9,865E-03 ! positive regulation of fibroblast proliferation GO:0048146 30 21 1,000 3,948E-04 0,01076882 ! apoptotic nuclear changes GO:0030262 31 21 1,000 3,948E-04 0,01064645 ! visual learning GO:0008542 38 21 1,000 3,948E-04 0,01052683 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 3,948E-04 0,01040986 ! negative regulation of T cell activation GO:0050868 35 21 1,000 3,948E-04 0,01029547 ! DNA catabolic process, endonucleolytic GO:0000737 27 22 1,000 4,339E-04 0,01119217 ! response to corticosteroid stimulus GO:0031960 37 23 1,000 4,748E-04 0,01211573 ! cellular response to extracellular stimulus GO:0031668 37 23 1,000 4,748E-04 0,01198684 ! positive regulation of B cell activation GO:0050871 36 23 1,000 4,748E-04 0,01186066 ! visual behavior GO:0007632 42 24 1,000 5,175E-04 0,01279298 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 46 24 1,000 5,175E-04 0,01266109 ! cell aging GO:0007569 38 24 1,000 5,175E-04 0,0125319 ! response to molecule of bacterial origin GO:0002237 38 24 1,000 5,175E-04 0,01240531 ! regulation of fibroblast proliferation GO:0048145 39 25 1,000 5,621E-04 0,01333758 ! regulation of cell-matrix adhesion GO:0001952 57 25 1,000 5,621E-04 0,01320552 GO:0010810|regulation of cell-substrate adhesion, ! negative regulation of phosphorylation GO:0042326 46 25 1,000 5,621E-04 0,01307605 ! leukocyte homeostasis GO:0001776 40 25 1,000 5,621E-04 0,0129491 ! positive regulation of nuclear division GO:0051785 41 25 1,000 5,621E-04 0,01282459 GO:0045840|positive regulation of mitosis, ! insulin receptor signaling pathway GO:0008286 48 26 1,000 6,084E-04 0,01374902 ! myofibril assembly GO:0030239 40 27 1,000 6,565E-04 0,01469605 GO:0055002|striated muscle cell development, ! negative regulation of phosphorus metabolic process GO:0010563 51 27 1,000 6,565E-04 0,01455871 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of neuron apoptosis GO:0043524 48 27 1,000 6,565E-04 0,01442391 ! negative regulation of protein modification process GO:0031400 56 28 1,000 7,063E-04 0,01537754 ! negative regulation of lymphocyte activation GO:0051250 48 28 1,000 7,063E-04 0,01523774 ! positive regulation of cell adhesion GO:0045785 54 29 1,000 7,58E-04 0,01620491 ! muscle cell development GO:0055001 42 29 1,000 7,58E-04 0,01606022 ! negative regulation of leukocyte activation GO:0002695 50 30 1,000 8,114E-04 0,01704026 ! regulation of synaptic plasticity GO:0048167 54 32 1,000 9,236E-04 0,01922589 ! cellular component assembly involved in morphogenesis GO:0010927 52 33 1,000 9,824E-04 0,02027066 ! protein targeting to membrane GO:0006612 63 33 1,000 9,824E-04 0,02009591 ! actomyosin structure organization GO:0031032 48 34 1,000 1,043E-03 0,021151 ! cell junction organization GO:0034330 72 35 1,000 1,105E-03 0,02222342 ! cytokinesis GO:0000910 57 35 1,000 1,105E-03 0,02203667 ! negative regulation of cell activation GO:0050866 58 35 1,000 1,105E-03 0,02185303 ! eye morphogenesis GO:0048592 64 36 1,000 1,169E-03 0,02292733 ! cellular response to insulin stimulus GO:0032869 60 36 1,000 1,169E-03 0,0227394 ! nucleus organization GO:0006997 58 37 1,000 1,235E-03 0,02382262 ! positive regulation of leukocyte proliferation GO:0070665 64 39 1,000 1,371E-03 0,0262459 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! establishment or maintenance of cell polarity GO:0007163 74 39 1,000 1,371E-03 0,02603593 ! RNA export from nucleus GO:0006405 57 41 1,000 1,515E-03 0,02853336 ! learning GO:0007612 75 42 1,000 1,589E-03 0,02969828 ! regulation of T cell proliferation GO:0042129 72 43 1,000 1,665E-03 0,03087679 ! G1/S transition of mitotic cell cycle GO:0000082 93 44 1,000 1,743E-03 0,03206846 ! receptor-mediated endocytosis GO:0006898 85 44 1,000 1,743E-03 0,03182178 ! cellular component disassembly GO:0022411 66 44 1,000 1,743E-03 0,03157887 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 58 44 1,000 1,743E-03 0,03133963 ! positive regulation of cell cycle GO:0045787 83 45 1,000 1,823E-03 0,03252241 ! vesicle organization GO:0016050 87 48 1,000 2,071E-03 0,03668351 ! regulation of neuron apoptosis GO:0043523 84 48 1,000 2,071E-03 0,03641178 ! induction of apoptosis by extracellular signals GO:0008624 96 49 1,000 2,158E-03 0,03764936 ! skeletal muscle fiber development GO:0048741 79 52 1,000 2,427E-03 0,04203199 ! negative regulation of immune system process GO:0002683 90 52 1,000 2,427E-03 0,04172741 ! protein amino acid autophosphorylation GO:0046777 97 52 1,000 2,427E-03 0,04142721 ! muscle fiber development GO:0048747 80 53 1,000 2,52E-03 0,04270717 ! cytokine-mediated signaling pathway GO:0019221 77 53 1,000 2,52E-03 0,04240428 ! regulation of mitosis GO:0007088 91 54 1,000 2,614E-03 0,04368714 GO:0051783|regulation of nuclear division, ! establishment of organelle localization GO:0051656 91 54 1,000 2,614E-03 0,04338163 ! DNA catabolic process GO:0006308 71 56 1,000 2,808E-03 0,04628135 ! positive regulation of organelle organization GO:0010638 95 56 1,000 2,808E-03 0,04596216 ! aging GO:0007568 91 57 1,000 2,908E-03 0,04726619 ! nuclear export GO:0051168 85 57 1,000 2,908E-03 0,04694465 ! positive regulation of growth GO:0045927 78 58 1,000 3,009E-03 0,04825079 ! DNA damage response, signal transduction GO:0042770 105 58 1,000 3,009E-03 0,04792696 ! negative regulation of cell growth GO:0030308 123 65 1,000 3,764E-03 0,05954232 ! organelle localization GO:0051640 105 65 1,000 3,764E-03 0,059148 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 96 66 1,000 3,878E-03 0,06054251 ! protein oligomerization GO:0051259 109 66 1,000 3,878E-03 0,0601468 ! cell cycle checkpoint GO:0000075 123 67 1,000 3,994E-03 0,06154145 ! negative regulation of cell size GO:0045792 125 67 1,000 3,994E-03 0,06114441 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 104 70 1,000 4,351E-03 0,0661853 ! regulation of actin cytoskeleton organization GO:0032956 120 72 1,000 4,597E-03 0,06948268 ! homeostasis of number of cells GO:0048872 109 72 1,000 4,597E-03 0,06904292 ! learning or memory GO:0007611 132 73 1,000 4,722E-03 0,07048015 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 108 73 1,000 4,722E-03 0,07003965 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 110 73 1,000 4,722E-03 0,06960462 ! activation of protein kinase activity GO:0032147 115 74 1,000 4,849E-03 0,07103484 ! regulation of actin filament-based process GO:0032970 122 74 1,000 4,849E-03 0,07059904 ! regulation of Rho protein signal transduction GO:0035023 126 74 1,000 4,849E-03 0,07016856 ! regulation of synaptic transmission GO:0050804 117 74 1,000 4,849E-03 0,0697433 ! regulation of Ras GTPase activity GO:0032318 125 76 1,000 5,108E-03 0,07302056 ! positive regulation of ligase activity GO:0051351 114 76 1,000 5,108E-03 0,07258331 ! negative regulation of growth GO:0045926 140 78 1,000 5,373E-03 0,0758929 ! regulation of ubiquitin-protein ligase activity GO:0051438 123 79 1,000 5,508E-03 0,07733631 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 123 80 1,000 5,644E-03 0,07878436 ! eye development GO:0001654 130 80 1,000 5,644E-03 0,07832364 ! regulation of transmission of nerve impulse GO:0051969 126 80 1,000 5,644E-03 0,07786827 ! response to steroid hormone stimulus GO:0048545 129 80 1,000 5,644E-03 0,07741816 ! cellular response to hormone stimulus GO:0032870 125 80 1,000 5,644E-03 0,07697323 ! regulation of ligase activity GO:0051340 129 82 1,000 5,921E-03 0,08029335 ! regulation of cell cycle process GO:0010564 139 83 1,000 6,062E-03 0,08173754 ! positive regulation of lymphocyte activation GO:0051251 134 83 1,000 6,062E-03 0,08127574 ! regulation of neurological system process GO:0031644 133 84 1,000 6,205E-03 0,0827186 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 130 85 1,000 6,349E-03 0,08416558 GO:0010498|proteasomal protein catabolic process, ! Golgi vesicle transport GO:0048193 145 87 1,000 6,641E-03 0,08755516 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 7,02E-03 0,09204003 ! positive regulation of protein ubiquitination GO:0031398 8 5 0,000 7,02E-03 0,09153432 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 5 0,000 7,02E-03 0,09103413 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 7,02E-03 0,09053938 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! negative regulation of tyrosine phosphorylation of Stat3 protein GO:0042518 13 5 0,000 7,02E-03 0,09004998 GO:0042532|negative regulation of tyrosine phosphorylation of STAT protein, ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 7,02E-03 0,08956584 ! regulation of cGMP biosynthetic process GO:0030826 7 5 0,000 7,02E-03 0,08908688 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 7,02E-03 0,08861301 ! positive regulation of actin filament polymerization GO:0030838 8 5 0,000 7,02E-03 0,08814416 ! positive regulation of tumor necrosis factor biosynthetic process GO:0042535 7 5 0,000 7,02E-03 0,08768024 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 7,02E-03 0,08722118 ! response to oxygen radical GO:0000305 11 5 0,000 7,02E-03 0,08676691 ! negative regulation of bone resorption GO:0045779 11 5 0,000 7,02E-03 0,08631734 ! myoblast cell fate commitment GO:0048625 8 5 0,000 7,02E-03 0,0858724 ! nucleotide-sugar transport GO:0015780 8 5 0,000 7,02E-03 0,08543203 ! positive regulation of lipid biosynthetic process GO:0046889 7 5 0,000 7,02E-03 0,08499615 ! regulation of interferon-beta production GO:0032648 5 5 0,000 7,02E-03 0,0845647 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 6 5 0,000 7,02E-03 0,08413761 GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 6 5 0,000 7,02E-03 0,0837148 ! female meiosis GO:0007143 8 5 0,000 7,02E-03 0,08329623 ! nose development GO:0043584 10 5 0,000 7,02E-03 0,08288182 ! DNA catabolic process, exonucleolytic GO:0000738 7 5 0,000 7,02E-03 0,08247152 ! regulation of cell adhesion mediated by integrin GO:0033628 15 5 0,000 7,02E-03 0,08206525 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 7,02E-03 0,08166297 ! short-chain fatty acid metabolic process GO:0046459 8 5 0,000 7,02E-03 0,08126462 ! tryptophanyl-tRNA aminoacylation GO:0006436 6 5 0,000 7,02E-03 0,08087013 ! cobalt ion transport GO:0006824 9 5 0,000 7,02E-03 0,08047945 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 7,02E-03 0,08009253 ! SMAD protein complex assembly GO:0007183 10 5 0,000 7,02E-03 0,07970931 ! phospholipid dephosphorylation GO:0046839 7 5 0,000 7,02E-03 0,07932974 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 7,02E-03 0,07895377 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 7,02E-03 0,07858135 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 7,02E-03 0,07821242 ! adaptation of signaling pathway GO:0022401 9 5 0,000 7,02E-03 0,07784694 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! cardiac muscle cell proliferation GO:0060038 7 5 0,000 7,02E-03 0,07748487 GO:0014855|striated muscle cell proliferation, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 7,02E-03 0,07712614 ! negative regulation of gene-specific transcription GO:0032582 10 5 0,000 7,02E-03 0,07677072 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 7,02E-03 0,07641856 ! negative regulation of histone modification GO:0031057 7 5 0,000 7,02E-03 0,07606962 ! malate metabolic process GO:0006108 8 5 0,000 7,02E-03 0,07572385 ! positive regulation of histone modification GO:0031058 6 5 0,000 7,02E-03 0,0753812 ! transcription from mitochondrial promoter GO:0006390 8 5 0,000 7,02E-03 0,07504165 ! clathrin coat assembly GO:0048268 11 5 0,000 7,02E-03 0,07470514 ! Notch receptor processing GO:0007220 8 5 0,000 7,02E-03 0,07437163 ! phototransduction, visible light GO:0007603 7 5 0,000 7,02E-03 0,07404109 ! regulation of dopamine uptake GO:0051584 9 5 0,000 7,02E-03 0,07371348 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 7,02E-03 0,07338875 ! mating behavior GO:0007617 6 5 0,000 7,02E-03 0,07306687 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 7,02E-03 0,0727478 ! copulation GO:0007620 8 5 0,000 7,02E-03 0,07243151 ! protein maturation by protein folding GO:0022417 13 5 0,000 7,02E-03 0,07211795 ! embryonic hemopoiesis GO:0035162 13 5 0,000 7,02E-03 0,0718071 ! regulation of potassium ion transport GO:0043266 9 5 0,000 7,02E-03 0,07149891 ! apoptotic cell clearance GO:0043277 14 5 0,000 7,02E-03 0,07119336 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine GO:0001993 9 5 0,000 7,02E-03 0,07089041 ! lipoprotein particle clearance GO:0034381 9 5 0,000 7,02E-03 0,07059003 ! fructose 1,6-bisphosphate metabolic process GO:0030388 8 5 0,000 7,02E-03 0,07029218 ! regulation of smooth muscle cell apoptosis GO:0034391 8 5 0,000 7,02E-03 0,06999683 ! negative regulation of stress-activated protein kinase signaling pathway GO:0070303 6 5 0,000 7,02E-03 0,06970396 GO:0046329|negative regulation of JNK cascade, ! oocyte maturation GO:0001556 6 5 0,000 7,02E-03 0,06941353 ! response to axon injury GO:0048678 8 5 0,000 7,02E-03 0,0691255 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 7,02E-03 0,06883986 ! response to protozoan GO:0001562 10 5 0,000 7,02E-03 0,06855657 ! negative regulation of heart contraction GO:0045822 12 5 0,000 7,02E-03 0,0682756 ! lymph vessel development GO:0001945 8 5 0,000 7,02E-03 0,06799692 ! regulation of activin receptor signaling pathway GO:0032925 11 5 0,000 7,02E-03 0,06772051 ! endochondral ossification GO:0001958 13 5 0,000 7,02E-03 0,06744634 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 7,02E-03 0,06717438 ! single strand break repair GO:0000012 5 5 0,000 7,02E-03 0,0669046 ! parathyroid gland development GO:0060017 8 5 0,000 7,02E-03 0,06663698 ! anagen GO:0042640 7 5 0,000 7,02E-03 0,0663715 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 7,02E-03 0,06610812 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 7,02E-03 0,06584682 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 7,02E-03 0,06558758 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 8 5 0,000 7,02E-03 0,06533038 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! smooth muscle tissue development GO:0048745 14 5 0,000 7,02E-03 0,06507518 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 7,02E-03 0,06482197 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 7,02E-03 0,06457072 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 7,02E-03 0,06432141 ! cardiac muscle fiber development GO:0048739 8 5 0,000 7,02E-03 0,06407402 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 7,02E-03 0,06382853 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 8 5 0,000 7,02E-03 0,06358491 ! neutrophil mediated immunity GO:0002446 6 5 0,000 7,02E-03 0,06334314 ! regulation of oligodendrocyte differentiation GO:0048713 15 5 0,000 7,02E-03 0,06310321 GO:0048715|negative regulation of oligodendrocyte differentiation, ! mitochondrion localization, microtubule-mediated GO:0034643 9 5 0,000 7,02E-03 0,06286508 GO:0047497|mitochondrion transport along microtubule, GO:0051654|establishment of mitochondrion localization, ! negative regulation of RNA splicing GO:0033119 6 5 0,000 7,02E-03 0,06262875 ! ionotropic glutamate receptor signaling pathway GO:0035235 10 5 0,000 7,02E-03 0,06239418 ! positive regulation of isotype switching to IgG isotypes GO:0048304 8 5 0,000 7,02E-03 0,06216137 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 7,02E-03 0,06193028 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 9 5 0,000 7,02E-03 0,06170091 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 7,02E-03 0,06147323 ! tyrosine catabolic process GO:0006572 7 5 0,000 7,02E-03 0,06124723 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 7,02E-03 0,06102288 ! proline biosynthetic process GO:0006561 6 5 0,000 7,02E-03 0,06080017 ! L-serine biosynthetic process GO:0006564 6 5 0,000 7,02E-03 0,06057908 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 7,02E-03 0,06035959 ! polyol catabolic process GO:0046174 7 5 0,000 7,02E-03 0,06014168 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 7,02E-03 0,05992535 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 7,02E-03 0,05971056 ! sister chromatid cohesion GO:0007062 10 5 0,000 7,02E-03 0,05949731 ! response to ATP GO:0033198 6 5 0,000 7,02E-03 0,05928557 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 9 5 0,000 7,02E-03 0,05907534 ! positive regulation of stress fiber formation GO:0051496 15 5 0,000 7,02E-03 0,05886659 ! neutrophil activation GO:0042119 6 5 0,000 7,02E-03 0,05865932 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 7,02E-03 0,0584535 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 7,02E-03 0,05824911 ! response to food GO:0032094 5 5 0,000 7,02E-03 0,05804615 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 7,02E-03 0,0578446 GO:0043088|regulation of Cdc42 GTPase activity, ! positive regulation of transporter activity GO:0032411 5 5 0,000 7,02E-03 0,05764445 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 8 5 0,000 7,02E-03 0,05744568 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 7,02E-03 0,05724827 ! paraxial mesoderm development GO:0048339 9 5 0,000 7,02E-03 0,05705221 ! forebrain neuron development GO:0021884 7 5 0,000 7,02E-03 0,0568575 ! melanosome organization GO:0032438 7 5 0,000 7,02E-03 0,0566641 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 7,02E-03 0,05647202 ! virus-infected cell apoptosis GO:0006926 8 5 0,000 7,02E-03 0,05628124 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 7,02E-03 0,05609174 ! positive regulation of neuroblast proliferation GO:0002052 9 5 0,000 7,02E-03 0,05590351 ! mesodermal cell fate determination GO:0007500 7 5 0,000 7,02E-03 0,05571654 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 7,02E-03 0,05553082 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 8 5 0,000 7,02E-03 0,05534633 ! nucleoside salvage GO:0043174 7 5 0,000 7,02E-03 0,05516307 GO:0006166|purine ribonucleoside salvage, ! lipid glycosylation GO:0030259 6 5 0,000 7,02E-03 0,05498101 ! attachment of GPI anchor to protein GO:0016255 10 5 0,000 7,02E-03 0,05480015 ! negative regulation of platelet activation GO:0010544 8 5 0,000 7,02E-03 0,05462048 GO:0010543|regulation of platelet activation, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 7,02E-03 0,05444198 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 7,02E-03 0,05426465 ! negative regulation of carbohydrate metabolic process GO:0045912 6 5 0,000 7,02E-03 0,05408846 GO:0010677|negative regulation of cellular carbohydrate metabolic process, ! positive regulation of fatty acid metabolic process GO:0045923 6 5 0,000 7,02E-03 0,05391342 ! early endosome to late endosome transport GO:0045022 11 5 0,000 7,02E-03 0,0537395 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 6 5 0,000 7,02E-03 0,05356671 ! depyrimidination GO:0045008 8 5 0,000 7,02E-03 0,05339502 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 7,02E-03 0,05322443 ! 5S class rRNA transcription GO:0042791 8 5 0,000 7,02E-03 0,05305492 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 5 0,000 7,02E-03 0,0528865 ! neuronal ion channel clustering GO:0045161 8 5 0,000 7,02E-03 0,05271913 ! sodium ion homeostasis GO:0055078 6 5 0,000 7,02E-03 0,05255283 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 7,02E-03 0,05238757 ! monocyte differentiation GO:0030224 7 5 0,000 7,02E-03 0,05222334 ! negative regulation of peptide secretion GO:0002792 8 5 0,000 7,02E-03 0,05206014 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 6 5 0,000 7,02E-03 0,05189796 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 7,02E-03 0,05173679 ! response to UV-C GO:0010225 7 5 0,000 7,02E-03 0,05157661 ! protein targeting to vacuole GO:0006623 6 5 0,000 7,02E-03 0,05141743 ! activated T cell proliferation GO:0050798 7 5 0,000 7,02E-03 0,05125922 ! negative regulation of alpha-beta T cell activation GO:0046636 7 5 0,000 7,02E-03 0,05110198 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! regulation of alpha-beta T cell proliferation GO:0046640 13 5 0,000 7,02E-03 0,05094571 GO:0046641|positive regulation of alpha-beta T cell proliferation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 7,02E-03 0,05079038 ! regulation of integrin biosynthetic process GO:0045113 9 5 0,000 7,02E-03 0,05063601 ! regulation of killing of cells of another organism GO:0051709 6 5 0,000 7,02E-03 0,05048256 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 7,02E-03 0,05033005 ! lymphoid progenitor cell differentiation GO:0002320 12 5 0,000 7,02E-03 0,05017845 ! positive regulation of T cell cytokine production GO:0002726 9 5 0,000 7,02E-03 0,05002777 GO:0032743|positive regulation of interleukin-2 production, ! L-ascorbic acid metabolic process GO:0019852 7 5 0,000 7,02E-03 0,04987798 ! base-excision repair, DNA ligation GO:0006288 5 5 0,000 7,02E-03 0,04972909 ! response to cadmium ion GO:0046686 8 5 0,000 7,02E-03 0,04958109 ! melanosome transport GO:0032402 8 5 0,000 7,02E-03 0,04943396 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 7,02E-03 0,04928771 ! regulation of acetylcholine secretion GO:0014056 10 5 0,000 7,02E-03 0,04914232 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 7,02E-03 0,04899778 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 7,02E-03 0,04885409 ! positive T cell selection GO:0043368 10 5 0,000 7,02E-03 0,04871125 ! purine deoxyribonucleotide catabolic process GO:0009155 6 5 0,000 7,02E-03 0,04856923 ! phosphatidylserine metabolic process GO:0006658 5 5 0,000 7,02E-03 0,04842804 ! regulation of interleukin-1 production GO:0032652 8 5 0,000 7,02E-03 0,04828767 ! ribosomal subunit assembly GO:0042257 5 5 0,000 7,02E-03 0,04814811 ! base conversion or substitution editing GO:0016553 6 5 0,000 7,02E-03 0,04800935 ! regulation of chondrocyte differentiation GO:0032330 9 5 0,000 7,02E-03 0,0478714 ! negative regulation of monooxygenase activity GO:0032769 10 5 0,000 7,02E-03 0,04773423 ! positive regulation of interleukin-10 production GO:0032733 5 5 0,000 7,02E-03 0,04759785 ! positive regulation of interleukin-12 production GO:0032735 5 5 0,000 7,02E-03 0,04746224 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 7,02E-03 0,0473274 ! histone demethylation GO:0016577 10 5 0,000 7,02E-03 0,04719333 ! mitotic recombination GO:0006312 10 5 0,000 7,02E-03 0,04706002 ! regulation of myeloid leukocyte mediated immunity GO:0002886 6 5 0,000 7,02E-03 0,04692745 ! regulation of sterol transport GO:0032371 7 5 0,000 7,02E-03 0,04679564 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 7,02E-03 0,04666456 ! sympathetic nervous system development GO:0048485 13 5 0,000 7,02E-03 0,04653421 ! enteric nervous system development GO:0048484 9 5 0,000 7,02E-03 0,04640459 ! oxygen homeostasis GO:0032364 8 5 0,000 7,02E-03 0,04627568 ! establishment of planar polarity GO:0001736 7 5 0,000 7,02E-03 0,0461475 ! lymphocyte costimulation GO:0031294 12 5 0,000 7,02E-03 0,04602002 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 6 5 0,000 7,02E-03 0,04589324 ! transcription termination GO:0006353 8 5 0,000 7,02E-03 0,04576716 ! plasminogen activation GO:0031639 5 5 0,000 7,02E-03 0,04564177 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 7,02E-03 0,04551707 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 7,02E-03 0,04539304 ! regulation of hair follicle development GO:0051797 9 5 0,000 7,02E-03 0,04526969 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 7,02E-03 0,04514701 ! apical protein localization GO:0045176 8 5 0,000 7,02E-03 0,04502499 ! definitive hemopoiesis GO:0060216 5 5 0,000 7,02E-03 0,04490363 ! negative regulation of myoblast differentiation GO:0045662 5 5 0,000 7,02E-03 0,04478292 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 7,02E-03 0,04466286 ! glucocorticoid biosynthetic process GO:0006704 6 5 0,000 7,02E-03 0,04454344 ! regulation of keratinocyte differentiation GO:0045616 7 5 0,000 7,02E-03 0,04442466 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 7,02E-03 0,04430651 ! regulation of centrosome duplication GO:0010824 6 5 0,000 7,02E-03 0,04418898 ! disaccharide metabolic process GO:0005984 9 5 0,000 7,02E-03 0,04407208 ! galactolipid metabolic process GO:0019374 8 5 0,000 7,02E-03 0,04395579 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 7,02E-03 0,04384012 GO:0033015|tetrapyrrole catabolic process, ! positive regulation of T cell mediated cytotoxicity GO:0001916 11 5 0,000 7,02E-03 0,04372506 ! determination of adult lifespan GO:0008340 8 5 0,000 7,02E-03 0,04361059 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 7,02E-03 0,04349673 ! ectodermal gut morphogenesis GO:0048567 6 5 0,000 7,02E-03 0,04338345 GO:0007439|ectodermal gut development, ! somatic stem cell maintenance GO:0035019 14 5 0,000 7,02E-03 0,04327077 ! T cell activation during immune response GO:0002286 9 5 0,000 7,02E-03 0,04315867 ! negative regulation of fibrinolysis GO:0051918 9 5 0,000 7,02E-03 0,04304715 ! negative regulation of lipase activity GO:0060192 7 5 0,000 7,02E-03 0,0429362 ! neural plate development GO:0001840 7 5 0,000 7,02E-03 0,04282583 ! regulation of sensory perception GO:0051931 6 5 0,000 7,02E-03 0,04271602 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 10 5 0,000 7,02E-03 0,04260677 ! regulation of histone acetylation GO:0035065 7 5 0,000 7,02E-03 0,04249808 ! sensory cilium assembly GO:0035058 6 5 0,000 7,02E-03 0,04238994 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 14 5 0,000 7,02E-03 0,04228235 ! diacylglycerol metabolic process GO:0046339 8 5 0,000 7,02E-03 0,04217531 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 7,02E-03 0,0420688 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! maternal placenta development GO:0001893 11 5 0,000 7,02E-03 0,04196284 ! negative regulation of smooth muscle contraction GO:0045986 10 5 0,000 7,02E-03 0,0418574 ! receptor biosynthetic process GO:0032800 6 5 0,000 7,02E-03 0,0417525 ! penetration of zona pellucida GO:0007341 9 5 0,000 7,02E-03 0,04164812 ! drug metabolic process GO:0017144 5 5 0,000 7,02E-03 0,04154425 ! protein amino acid prenylation GO:0018346 9 5 0,000 7,02E-03 0,04144091 ! organ regeneration GO:0031100 7 5 0,000 7,02E-03 0,04133808 ! carnitine metabolic process GO:0009437 5 5 0,000 7,02E-03 0,04123576 GO:0006577|betaine metabolic process, ! skeletal muscle tissue development GO:0007519 135 90 1,000 7,092E-03 0,04155134 GO:0060538|skeletal muscle organ development, ! transcription initiation GO:0006352 128 90 1,000 7,092E-03 0,04144899 ! regulation of GTPase activity GO:0043087 149 90 1,000 7,092E-03 0,04134715 ! positive regulation of cell activation GO:0050867 146 90 1,000 7,092E-03 0,04124581 GO:0002696|positive regulation of leukocyte activation, ! cell cycle arrest GO:0007050 171 93 1,000 7,555E-03 0,04383553 ! positive regulation of MAP kinase activity GO:0043406 143 93 1,000 7,555E-03 0,04372861 ! regulation of cell adhesion GO:0030155 187 94 1,000 7,713E-03 0,04453193 ! regulation of T cell activation GO:0050863 155 98 1,000 8,358E-03 0,04813918 ! tRNA transcription GO:0009304 11 6 0,000 8,419E-03 0,04837176 ! negative regulation of S phase of mitotic cell cycle GO:0045749 13 6 0,000 8,419E-03 0,04825492 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 8,419E-03 0,04813864 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 8 6 0,000 8,419E-03 0,04802292 ! regulation of helicase activity GO:0051095 11 6 0,000 8,419E-03 0,04790776 ! regulation of cGMP metabolic process GO:0030823 8 6 0,000 8,419E-03 0,04779315 ! sleep GO:0030431 13 6 0,000 8,419E-03 0,04767908 ! positive regulation of axon extension GO:0045773 10 6 0,000 8,419E-03 0,04756556 ! negative regulation of small GTPase mediated signal transduction GO:0051058 11 6 0,000 8,419E-03 0,04745258 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 8,419E-03 0,04734013 ! forebrain regionalization GO:0021871 7 6 0,000 8,419E-03 0,04722822 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 8,419E-03 0,04711683 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 8,419E-03 0,04700597 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 8,419E-03 0,04689562 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 8,419E-03 0,0467858 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 18 6 0,000 8,419E-03 0,04667648 ! regulation of protein export from nucleus GO:0046825 8 6 0,000 8,419E-03 0,04656768 ! neuron adhesion GO:0007158 9 6 0,000 8,419E-03 0,04645938 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 8,419E-03 0,04635159 ! signal peptide processing GO:0006465 8 6 0,000 8,419E-03 0,04624429 ! embryonic camera-type eye development GO:0031076 11 6 0,000 8,419E-03 0,04613749 GO:0048596|embryonic camera-type eye morphogenesis, ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 8,419E-03 0,04603119 ! glucocorticoid receptor signaling pathway GO:0042921 11 6 0,000 8,419E-03 0,04592537 GO:0031958|corticosteroid receptor signaling pathway, ! citrate metabolic process GO:0006101 10 6 0,000 8,419E-03 0,04582003 ! fibril organization GO:0043206 13 6 0,000 8,419E-03 0,04571518 ! regulation of mitochondrial membrane permeability GO:0046902 12 6 0,000 8,419E-03 0,04561081 ! neurofilament cytoskeleton organization GO:0060052 10 6 0,000 8,419E-03 0,04550691 ! posttranscriptional gene silencing by RNA GO:0035194 14 6 0,000 8,419E-03 0,04540349 GO:0016441|posttranscriptional gene silencing, ! behavioral response to pain GO:0048266 10 6 0,000 8,419E-03 0,04530053 ! protein refolding GO:0042026 13 6 0,000 8,419E-03 0,04519804 ! metabotropic glutamate receptor signaling pathway GO:0007216 8 6 0,000 8,419E-03 0,04509602 ! rhythmic behavior GO:0007622 14 6 0,000 8,419E-03 0,04499445 ! glial cell fate commitment GO:0021781 17 6 0,000 8,419E-03 0,04489334 ! erythrocyte maturation GO:0043249 7 6 0,000 8,419E-03 0,04479268 ! sensory perception of temperature stimulus GO:0050951 12 6 0,000 8,419E-03 0,04469247 ! protein amino acid dealkylation GO:0008214 12 6 0,000 8,419E-03 0,04459271 GO:0006482|protein amino acid demethylation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 8,419E-03 0,0444934 ! regulation of odontogenesis GO:0042481 8 6 0,000 8,419E-03 0,04439452 ! mechanosensory behavior GO:0007638 8 6 0,000 8,419E-03 0,04429609 ! ovulation from ovarian follicle GO:0001542 7 6 0,000 8,419E-03 0,04419809 ! negative regulation of endocytosis GO:0045806 8 6 0,000 8,419E-03 0,04410052 ! response to interferon-gamma GO:0034341 12 6 0,000 8,419E-03 0,04400338 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 8,419E-03 0,04390667 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 9 6 0,000 8,419E-03 0,04381038 ! negative regulation of viral genome replication GO:0045071 8 6 0,000 8,419E-03 0,04371452 ! positive regulation of interleukin-12 biosynthetic process GO:0045084 6 6 0,000 8,419E-03 0,04361907 ! spinal cord dorsal/ventral patterning GO:0021513 8 6 0,000 8,419E-03 0,04352404 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 17 6 0,000 8,419E-03 0,04342942 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 11 6 0,000 8,419E-03 0,04333522 ! cGMP-mediated signaling GO:0019934 11 6 0,000 8,419E-03 0,04324142 ! activation of MAPKKK activity GO:0000185 11 6 0,000 8,419E-03 0,04314802 ! inositol phosphate-mediated signaling GO:0048016 10 6 0,000 8,419E-03 0,04305503 ! protein lipoylation GO:0009249 10 6 0,000 8,419E-03 0,04296244 ! pigment granule organization GO:0048753 11 6 0,000 8,419E-03 0,04287025 ! drug transport GO:0015893 6 6 0,000 8,419E-03 0,04277845 ! transepithelial chloride transport GO:0030321 10 6 0,000 8,419E-03 0,04268704 GO:0070633|transepithelial transport, ! cysteine metabolic process GO:0006534 8 6 0,000 8,419E-03 0,04259602 ! negative regulation of survival gene product expression GO:0008634 9 6 0,000 8,419E-03 0,04250539 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 8,419E-03 0,04241515 ! regulation of defense response to virus by host GO:0050691 7 6 0,000 8,419E-03 0,04232529 ! glutamate catabolic process GO:0006538 11 6 0,000 8,419E-03 0,0422358 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 8,419E-03 0,0421467 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 8,419E-03 0,04205797 ! adenohypophysis development GO:0021984 10 6 0,000 8,419E-03 0,04196961 ! response to pH GO:0009268 10 6 0,000 8,419E-03 0,04188163 ! hyperosmotic response GO:0006972 9 6 0,000 8,419E-03 0,04179401 ! microtubule nucleation GO:0007020 10 6 0,000 8,419E-03 0,04170675 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 6 0,000 8,419E-03 0,04161987 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 6 0,000 8,419E-03 0,04153334 ! melanin biosynthetic process from tyrosine GO:0006583 9 6 0,000 8,419E-03 0,04144717 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 8,419E-03 0,04136136 ! vascular smooth muscle contraction GO:0014829 11 6 0,000 8,419E-03 0,0412759 ! regulation of retinoic acid receptor signaling pathway GO:0048385 13 6 0,000 8,419E-03 0,04119079 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 8,419E-03 0,04110604 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 8,419E-03 0,04102163 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 8,419E-03 0,04093757 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 8,419E-03 0,04085386 ! purine salvage GO:0043101 9 6 0,000 8,419E-03 0,04077048 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 8,419E-03 0,04068744 ! peptidyl-threonine phosphorylation GO:0018107 16 6 0,000 8,419E-03 0,04060475 ! nucleoside transport GO:0015858 7 6 0,000 8,419E-03 0,04052238 ! organic alcohol transport GO:0015850 9 6 0,000 8,419E-03 0,04044035 ! T cell mediated immunity GO:0002456 12 6 0,000 8,419E-03 0,04035866 ! folic acid transport GO:0015884 11 6 0,000 8,419E-03 0,04027729 ! male sex determination GO:0030238 11 6 0,000 8,419E-03 0,04019625 ! carnitine transport GO:0015879 8 6 0,000 8,419E-03 0,04011553 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 8,419E-03 0,04003514 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 8,419E-03 0,03995507 ! negative regulation of DNA recombination GO:0045910 10 6 0,000 8,419E-03 0,03987532 ! positive regulation of exocytosis GO:0045921 9 6 0,000 8,419E-03 0,03979589 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 8,419E-03 0,03971677 ! parturition GO:0007567 13 6 0,000 8,419E-03 0,03963797 ! determination of anterior/posterior axis, embryo GO:0008595 10 6 0,000 8,419E-03 0,03955948 GO:0007351|tripartite regional subdivision, ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 8,419E-03 0,03948129 ! lipopolysaccharide biosynthetic process GO:0009103 6 6 0,000 8,419E-03 0,03940342 ! regulation of centrosome cycle GO:0046605 8 6 0,000 8,419E-03 0,03932586 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 8,419E-03 0,0392486 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 8,419E-03 0,03917164 ! regulation of cholesterol biosynthetic process GO:0045540 8 6 0,000 8,419E-03 0,03909498 ! homeostasis of number of cells within a tissue GO:0048873 10 6 0,000 8,419E-03 0,03901862 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 8,419E-03 0,03894256 ! negative regulation of gliogenesis GO:0014014 17 6 0,000 8,419E-03 0,0388668 GO:0045686|negative regulation of glial cell differentiation, ! macrophage differentiation GO:0030225 10 6 0,000 8,419E-03 0,03879133 ! neural nucleus development GO:0048857 12 6 0,000 8,419E-03 0,03871615 ! forebrain morphogenesis GO:0048853 14 6 0,000 8,419E-03 0,03864127 ! hyaluronan metabolic process GO:0030212 7 6 0,000 8,419E-03 0,03856667 ! purine base biosynthetic process GO:0009113 14 6 0,000 8,419E-03 0,03849236 ! interaction with symbiont GO:0051702 9 6 0,000 8,419E-03 0,03841834 ! regulation of dendrite development GO:0050773 13 6 0,000 8,419E-03 0,0383446 ! anterograde axon cargo transport GO:0008089 9 6 0,000 8,419E-03 0,03827114 ! positive regulation of organ growth GO:0046622 7 6 0,000 8,419E-03 0,03819796 ! eating behavior GO:0042755 6 6 0,000 8,419E-03 0,03812507 ! regulation of T cell cytokine production GO:0002724 11 6 0,000 8,419E-03 0,03805245 ! transcription-coupled nucleotide-excision repair GO:0006283 7 6 0,000 8,419E-03 0,0379801 ! response to copper ion GO:0046688 9 6 0,000 8,419E-03 0,03790804 ! negative regulation of lymphocyte mediated immunity GO:0002707 13 6 0,000 8,419E-03 0,03783624 GO:0002704|negative regulation of leukocyte mediated immunity, ! response to exogenous dsRNA GO:0043330 8 6 0,000 8,419E-03 0,03776472 ! establishment of melanosome localization GO:0032401 9 6 0,000 8,419E-03 0,03769346 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 8,419E-03 0,03762248 ! negative regulation of protein kinase B signaling cascade GO:0051898 12 6 0,000 8,419E-03 0,03755176 ! positive regulation of B cell differentiation GO:0045579 10 6 0,000 8,419E-03 0,0374813 ! regulation of dopamine secretion GO:0014059 14 6 0,000 8,419E-03 0,03741111 ! nucleoside catabolic process GO:0009164 7 6 0,000 8,419E-03 0,03734119 ! hair follicle maturation GO:0048820 8 6 0,000 8,419E-03 0,03727152 ! cranial nerve morphogenesis GO:0021602 7 6 0,000 8,419E-03 0,03720211 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 8,419E-03 0,03713297 ! positive regulation of interleukin-5 production GO:0032754 9 6 0,000 8,419E-03 0,03706407 GO:0032736|positive regulation of interleukin-13 production, ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 8,419E-03 0,03699544 ! rhombomere development GO:0021546 6 6 0,000 8,419E-03 0,03692705 ! G2 phase GO:0051319 15 6 0,000 8,419E-03 0,03685892 GO:0000085|G2 phase of mitotic cell cycle, ! regulation of mast cell activation GO:0033003 7 6 0,000 8,419E-03 0,03679104 ! muscle cell proliferation GO:0033002 9 6 0,000 8,419E-03 0,03672341 ! membrane to membrane docking GO:0022614 12 6 0,000 8,419E-03 0,03665603 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 10 6 0,000 8,419E-03 0,03658889 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! response to tumor cell GO:0002347 12 6 0,000 8,419E-03 0,036522 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 6 0,000 8,419E-03 0,03645536 ! receptor internalization GO:0031623 9 6 0,000 8,419E-03 0,03638895 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 8,419E-03 0,03632279 GO:0031272|regulation of pseudopodium assembly, ! regulation of respiratory burst GO:0060263 9 6 0,000 8,419E-03 0,03625687 ! coenzyme A metabolic process GO:0015936 9 6 0,000 8,419E-03 0,03619119 ! myeloid dendritic cell activation GO:0001773 11 6 0,000 8,419E-03 0,03612574 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 12 6 0,000 8,419E-03 0,03606053 ! peptidyl-histidine modification GO:0018202 10 6 0,000 8,419E-03 0,03599556 ! axonal fasciculation GO:0007413 10 6 0,000 8,419E-03 0,03593082 ! regulation of muscle cell apoptosis GO:0010660 9 6 0,000 8,419E-03 0,03586631 ! energy coupled proton transport, against electrochemical gradient GO:0015988 7 6 0,000 8,419E-03 0,03580203 GO:0015991|ATP hydrolysis coupled proton transport, ! midbrain development GO:0030901 7 6 0,000 8,419E-03 0,03573799 ! tyrosine phosphorylation of STAT protein GO:0007260 7 6 0,000 8,419E-03 0,03567417 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 8,419E-03 0,03561058 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 7 6 0,000 8,419E-03 0,03554722 ! progesterone metabolic process GO:0042448 8 6 0,000 8,419E-03 0,03548408 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 8,419E-03 0,03542116 ! glycolipid catabolic process GO:0019377 14 6 0,000 8,419E-03 0,03535847 GO:0046479|glycosphingolipid catabolic process, ! nonprotein amino acid metabolic process GO:0019794 10 6 0,000 8,419E-03 0,035296 ! negative regulation of axon extension GO:0030517 13 6 0,000 8,419E-03 0,03523375 ! removal of superoxide radicals GO:0019430 10 6 0,000 8,419E-03 0,03517172 ! triglyceride catabolic process GO:0019433 8 6 0,000 8,419E-03 0,0351099 ! protein modification by small protein removal GO:0070646 10 6 0,000 8,419E-03 0,03504831 GO:0016579|protein deubiquitination, ! adult feeding behavior GO:0008343 6 6 0,000 8,419E-03 0,03498693 ! glial cell migration GO:0008347 11 6 0,000 8,419E-03 0,03492576 ! blastocyst growth GO:0001832 17 6 0,000 8,419E-03 0,03486481 ! pigment granule transport GO:0051904 12 6 0,000 8,419E-03 0,03480407 ! lymphocyte activation during immune response GO:0002285 10 6 0,000 8,419E-03 0,03474354 ! cerebellar cortex formation GO:0021697 9 6 0,000 8,419E-03 0,03468322 ! catecholamine transport GO:0051937 7 6 0,000 8,419E-03 0,03462311 ! hemopoietic progenitor cell differentiation GO:0002244 14 6 0,000 8,419E-03 0,03456321 ! positive regulation of actin filament bundle formation GO:0032233 16 6 0,000 8,419E-03 0,03450352 ! organ or tissue specific immune response GO:0002251 7 6 0,000 8,419E-03 0,03444403 ! positive regulation of smooth muscle contraction GO:0045987 10 6 0,000 8,419E-03 0,03438474 ! spindle assembly GO:0051225 6 6 0,000 8,419E-03 0,03432566 ! ensheathment of axons in the peripheral nervous system GO:0032292 15 6 0,000 8,419E-03 0,03426678 GO:0022011|myelination in the peripheral nervous system, ! protein prenylation GO:0018342 10 6 0,000 8,419E-03 0,03420811 ! negative regulation of synaptic transmission GO:0050805 12 6 0,000 8,419E-03 0,03414963 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 8,419E-03 0,03409136 ! NAD biosynthetic process GO:0009435 9 6 0,000 8,419E-03 0,03403328 ! positive regulation of coagulation GO:0050820 11 6 0,000 8,419E-03 0,0339754 ! cellular anion homeostasis GO:0030002 9 6 0,000 8,419E-03 0,03391772 GO:0055081|anion homeostasis, ! cell fate commitment GO:0045165 165 99 1,000 8,523E-03 0,03427925 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 9,815E-03 0,03941001 ! behavioral response to cocaine GO:0048148 13 7 0,000 9,815E-03 0,03934344 ! autophagic vacuole formation GO:0000045 12 7 0,000 9,815E-03 0,0392771 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 9,815E-03 0,03921097 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 10 7 0,000 9,815E-03 0,03914507 ! chaperone mediated protein folding requiring cofactor GO:0051085 9 7 0,000 9,815E-03 0,03907939 ! prostate gland development GO:0030850 11 7 0,000 9,815E-03 0,03901393 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 9,815E-03 0,03894869 ! regulation of hormone biosynthetic process GO:0046885 12 7 0,000 9,815E-03 0,03888367 ! synaptonemal complex assembly GO:0007130 11 7 0,000 9,815E-03 0,03881886 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 10 7 0,000 9,815E-03 0,03875427 ! male meiosis GO:0007140 10 7 0,000 9,815E-03 0,0386899 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 9,815E-03 0,03862573 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! reproductive behavior GO:0019098 12 7 0,000 9,815E-03 0,03856178 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 9,815E-03 0,03849805 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 9,815E-03 0,03843452 ! oligopeptide transport GO:0006857 11 7 0,000 9,815E-03 0,0383712 ! protein amino acid sulfation GO:0006477 9 7 0,000 9,815E-03 0,03830809 GO:0051923|sulfation, ! N-terminal protein amino acid acetylation GO:0006474 9 7 0,000 9,815E-03 0,03824519 ! establishment of tissue polarity GO:0007164 10 7 0,000 9,815E-03 0,03818249 ! receptor guanylyl cyclase signaling pathway GO:0007168 7 7 0,000 9,815E-03 0,03812 ! RNA methylation GO:0001510 11 7 0,000 9,815E-03 0,03805771 ! negative regulation of cell-cell adhesion GO:0022408 20 7 0,000 9,815E-03 0,03799562 ! positive regulation of cell-cell adhesion GO:0022409 17 7 0,000 9,815E-03 0,03793374 ! pericardium development GO:0060039 9 7 0,000 9,815E-03 0,03787206 ! macrophage chemotaxis GO:0048246 10 7 0,000 9,815E-03 0,03781058 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 9,815E-03 0,0377493 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 9,815E-03 0,03768822 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 9,815E-03 0,03762733 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 9,815E-03 0,03756664 ! cerebral cortex cell migration GO:0021795 11 7 0,000 9,815E-03 0,03750615 ! opsonization GO:0008228 9 7 0,000 9,815E-03 0,03744585 ! tachykinin receptor signaling pathway GO:0007217 12 7 0,000 9,815E-03 0,03738574 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 9,815E-03 0,03732583 ! regulation of dopamine metabolic process GO:0042053 10 7 0,000 9,815E-03 0,03726611 GO:0042069|regulation of catecholamine metabolic process, ! glucocorticoid metabolic process GO:0008211 8 7 0,000 9,815E-03 0,03720658 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 9,815E-03 0,03714724 ! chemosensory behavior GO:0007635 9 7 0,000 9,815E-03 0,03708809 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 9,815E-03 0,03702912 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 9,815E-03 0,03697035 ! leukocyte degranulation GO:0043299 11 7 0,000 9,815E-03 0,03691176 ! positive regulation of glycolysis GO:0045821 13 7 0,000 9,815E-03 0,03685335 ! DNA ligation during DNA repair GO:0051103 10 7 0,000 9,815E-03 0,03679513 ! positive regulation of heart rate GO:0010460 11 7 0,000 9,815E-03 0,03673709 ! protein-cofactor linkage GO:0018065 13 7 0,000 9,815E-03 0,03667924 ! lipopolysaccharide metabolic process GO:0008653 7 7 0,000 9,815E-03 0,03662157 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 9,815E-03 0,03656408 ! spinal cord patterning GO:0021511 9 7 0,000 9,815E-03 0,03650677 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 9,815E-03 0,03644964 ! thymic T cell selection GO:0045061 15 7 0,000 9,815E-03 0,03639268 ! regulation of transcriptional preinitiation complex assembly GO:0045898 11 7 0,000 9,815E-03 0,03633591 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 9,815E-03 0,03627931 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 9,815E-03 0,03622289 ! ovulation GO:0030728 8 7 0,000 9,815E-03 0,03616664 ! regulation of isotype switching to IgG isotypes GO:0048302 11 7 0,000 9,815E-03 0,03611057 ! histidine metabolic process GO:0006547 7 7 0,000 9,815E-03 0,03605467 GO:0009075|histidine family amino acid metabolic process, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 7 0,000 9,815E-03 0,03599895 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 9,815E-03 0,03594339 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! deoxyribonucleotide biosynthetic process GO:0009263 9 7 0,000 9,815E-03 0,03588801 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 8 7 0,000 9,815E-03 0,0358328 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! ER overload response GO:0006983 8 7 0,000 9,815E-03 0,03577775 ! thyroid hormone generation GO:0006590 11 7 0,000 9,815E-03 0,03572288 ! endosome organization GO:0007032 10 7 0,000 9,815E-03 0,03566817 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 9,815E-03 0,03561364 GO:0021940|positive regulation of granule cell precursor proliferation, ! positive regulation of interleukin-8 biosynthetic process GO:0045416 8 7 0,000 9,815E-03 0,03555926 ! phasic smooth muscle contraction GO:0014821 13 7 0,000 9,815E-03 0,03550506 ! urea metabolic process GO:0019627 9 7 0,000 9,815E-03 0,03545102 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 14 7 0,000 9,815E-03 0,03539714 ! vesicle fusion GO:0006906 15 7 0,000 9,815E-03 0,03534343 ! positive regulation of insulin secretion GO:0032024 9 7 0,000 9,815E-03 0,03528988 ! maintenance of protein location in nucleus GO:0051457 17 7 0,000 9,815E-03 0,03523649 ! intracellular pH reduction GO:0051452 11 7 0,000 9,815E-03 0,03518326 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 10 7 0,000 9,815E-03 0,03513019 GO:0046464|acylglycerol catabolic process, ! asymmetric protein localization GO:0008105 10 7 0,000 9,815E-03 0,03507729 ! organ growth GO:0035265 13 7 0,000 9,815E-03 0,03502454 ! positive regulation of mesenchymal cell proliferation GO:0002053 10 7 0,000 9,815E-03 0,03497195 ! Rac protein signal transduction GO:0016601 7 7 0,000 9,815E-03 0,03491952 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 7 0,000 9,815E-03 0,03486724 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 8 7 0,000 9,815E-03 0,03481512 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! retinol metabolic process GO:0042572 9 7 0,000 9,815E-03 0,03476316 ! rRNA modification GO:0000154 12 7 0,000 9,815E-03 0,03471135 ! negative regulation of translational initiation GO:0045947 9 7 0,000 9,815E-03 0,0346597 ! DNA damage response, signal transduction resulting in transcription GO:0042772 14 7 0,000 9,815E-03 0,0346082 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! protein heterooligomerization GO:0051291 10 7 0,000 9,815E-03 0,03455685 ! response to UV-B GO:0010224 11 7 0,000 9,815E-03 0,03450566 ! astrocyte development GO:0014002 15 7 0,000 9,815E-03 0,03445461 ! intermediate filament organization GO:0045109 12 7 0,000 9,815E-03 0,03440372 ! cardiac muscle cell development GO:0055013 9 7 0,000 9,815E-03 0,03435298 ! fibrinolysis GO:0042730 9 7 0,000 9,815E-03 0,03430238 ! peptidyl-arginine modification GO:0018195 9 7 0,000 9,815E-03 0,03425194 ! negative regulation of insulin receptor signaling pathway GO:0046627 12 7 0,000 9,815E-03 0,03420164 ! blastoderm segmentation GO:0007350 11 7 0,000 9,815E-03 0,03415149 ! skeletal muscle contraction GO:0003009 8 7 0,000 9,815E-03 0,03410149 ! B cell lineage commitment GO:0002326 17 7 0,000 9,815E-03 0,03405163 ! DNA topological change GO:0006265 10 7 0,000 9,815E-03 0,03400192 ! regulation of fat cell differentiation GO:0045598 10 7 0,000 9,815E-03 0,03395236 ! melanosome localization GO:0032400 10 7 0,000 9,815E-03 0,03390294 ! enucleate erythrocyte differentiation GO:0043353 10 7 0,000 9,815E-03 0,03385366 ! regulation of interleukin-5 production GO:0032674 10 7 0,000 9,815E-03 0,03380453 ! glycosylceramide metabolic process GO:0006677 10 7 0,000 9,815E-03 0,03375553 ! mast cell activation GO:0045576 10 7 0,000 9,815E-03 0,03370668 ! multicellular organismal aging GO:0010259 11 7 0,000 9,815E-03 0,03365797 ! negative regulation of focal adhesion formation GO:0051895 16 7 0,000 9,815E-03 0,03360941 ! gas homeostasis GO:0033483 12 7 0,000 9,815E-03 0,03356098 ! negative regulation of T cell differentiation GO:0045581 9 7 0,000 9,815E-03 0,03351269 ! phosphatidylinositol biosynthetic process GO:0006661 11 7 0,000 9,815E-03 0,03346454 ! Schwann cell development GO:0014044 16 7 0,000 9,815E-03 0,03341653 ! dendrite morphogenesis GO:0048813 12 7 0,000 9,815E-03 0,03336865 ! regulation of interleukin-13 production GO:0032656 12 7 0,000 9,815E-03 0,03332091 ! positive regulation of interleukin-4 production GO:0032753 10 7 0,000 9,815E-03 0,03327331 ! molybdopterin cofactor biosynthetic process GO:0032324 10 7 0,000 9,815E-03 0,03322585 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! cell differentiation in hindbrain GO:0021533 11 7 0,000 9,815E-03 0,03317852 ! neural tube patterning GO:0021532 8 7 0,000 9,815E-03 0,03313132 ! histone ubiquitination GO:0016574 10 7 0,000 9,815E-03 0,03308426 ! regulation of meiosis GO:0040020 12 7 0,000 9,815E-03 0,03303733 GO:0051445|regulation of meiotic cell cycle, ! T cell lineage commitment GO:0002360 12 7 0,000 9,815E-03 0,03299054 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 9,815E-03 0,03294387 GO:0002714|positive regulation of B cell mediated immunity, ! mitochondrion morphogenesis GO:0070584 12 7 0,000 9,815E-03 0,03289734 ! regulation of lipid transport GO:0032368 13 7 0,000 9,815E-03 0,03285094 ! regulation of cell division GO:0051302 9 7 0,000 9,815E-03 0,03280467 ! regulation of inflammatory response to antigenic stimulus GO:0002861 14 7 0,000 9,815E-03 0,03275853 ! neutrophil homeostasis GO:0001780 8 7 0,000 9,815E-03 0,03271253 ! regulation of macrophage activation GO:0043030 12 7 0,000 9,815E-03 0,03266665 ! negative regulation of nuclear division GO:0051784 18 7 0,000 9,815E-03 0,03262089 GO:0045839|negative regulation of mitosis, ! diuresis GO:0030146 11 7 0,000 9,815E-03 0,03257527 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 9 7 0,000 9,815E-03 0,03252977 ! positive regulation of epidermis development GO:0045684 11 7 0,000 9,815E-03 0,0324844 ! thiamin metabolic process GO:0006772 8 7 0,000 9,815E-03 0,03243916 ! positive regulation of leukocyte chemotaxis GO:0002690 15 7 0,000 9,815E-03 0,03239404 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of epidermal cell differentiation GO:0045604 10 7 0,000 9,815E-03 0,03234905 ! negative regulation of transmission of nerve impulse GO:0051970 13 7 0,000 9,815E-03 0,03230419 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 9,815E-03 0,03225944 ! dopamine biosynthetic process GO:0042416 15 7 0,000 9,815E-03 0,03221482 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 9,815E-03 0,03217033 ! lymph node development GO:0048535 9 7 0,000 9,815E-03 0,03212596 ! anterior/posterior axis specification GO:0009948 11 7 0,000 9,815E-03 0,03208171 ! negative regulation of viral reproduction GO:0048525 9 7 0,000 9,815E-03 0,03203758 ! regulation of T cell mediated cytotoxicity GO:0001914 15 7 0,000 9,815E-03 0,03199357 ! positive regulation of glucose import GO:0046326 7 7 0,000 9,815E-03 0,03194968 GO:0010828|positive regulation of glucose transport, ! endosome to lysosome transport GO:0008333 11 7 0,000 9,815E-03 0,03190592 ! ATP catabolic process GO:0006200 10 7 0,000 9,815E-03 0,03186227 ! establishment of pigment granule localization GO:0051905 13 7 0,000 9,815E-03 0,03181874 ! positive regulation of fibrinolysis GO:0051919 8 7 0,000 9,815E-03 0,03177533 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 9,815E-03 0,03173204 ! negative regulation of calcium ion transport GO:0051926 8 7 0,000 9,815E-03 0,03168887 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 9,815E-03 0,03164581 ! positive regulation of blood vessel endothelial cell migration GO:0043536 17 7 0,000 9,815E-03 0,03160287 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 9,815E-03 0,03156005 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 9,815E-03 0,03151735 ! muscle adaptation GO:0043500 12 7 0,000 9,815E-03 0,03147475 ! amino sugar catabolic process GO:0046348 9 7 0,000 9,815E-03 0,03143228 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 8 7 0,000 9,815E-03 0,03138992 ! retina homeostasis GO:0001895 9 7 0,000 9,815E-03 0,03134767 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 9,815E-03 0,03130553 ! regulation of growth hormone secretion GO:0060123 14 7 0,000 9,815E-03 0,03126351 ! regulation of T cell receptor signaling pathway GO:0050856 12 7 0,000 9,815E-03 0,03122161 ! positive regulation of microtubule polymerization GO:0031116 12 7 0,000 9,815E-03 0,03117981 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 9,815E-03 0,03113813 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 8 0,000 0,01120969 0,03551482 GO:0045346|regulation of MHC class II biosynthetic process, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 16 8 0,000 0,01120969 0,03546747 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,01120969 0,03542024 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! oligosaccharide biosynthetic process GO:0009312 14 8 0,000 0,01120969 0,03537314 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 10 8 0,000 0,01120969 0,03532616 ! negative regulation of cellular catabolic process GO:0031330 10 8 0,000 0,01120969 0,03527931 ! generation of neurons in the forebrain GO:0021872 11 8 0,000 0,01120969 0,03523258 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,01120969 0,03518598 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,01120969 0,0351395 ! neutral lipid catabolic process GO:0046461 11 8 0,000 0,01120969 0,03509314 ! N-glycan processing GO:0006491 12 8 0,000 0,01120969 0,0350469 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,01120969 0,03500079 ! glycosaminoglycan catabolic process GO:0006027 11 8 0,000 0,01120969 0,0349548 ! negative regulation of JAK-STAT cascade GO:0046426 18 8 0,000 0,01120969 0,03490892 ! mRNA stabilization GO:0048255 16 8 0,000 0,01120969 0,03486317 GO:0043489|RNA stabilization, ! induction of positive chemotaxis GO:0050930 16 8 0,000 0,01120969 0,03481754 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,01120969 0,03477203 ! lipoprotein transport GO:0042953 14 8 0,000 0,01120969 0,03472663 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,01120969 0,03468136 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,01120969 0,0346362 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,01120969 0,03459116 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,01120969 0,03454623 ! amyloid precursor protein catabolic process GO:0042987 13 8 0,000 0,01120969 0,03450143 ! bile acid and bile salt transport GO:0015721 12 8 0,000 0,01120969 0,03445674 ! ganglioside metabolic process GO:0001573 16 8 0,000 0,01120969 0,03441216 ! regulation of mesenchymal cell proliferation GO:0010464 12 8 0,000 0,01120969 0,0343677 ! reflex GO:0060004 16 8 0,000 0,01120969 0,03432336 ! positive regulation of isotype switching GO:0045830 16 8 0,000 0,01120969 0,03427912 GO:0045911|positive regulation of DNA recombination, ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,01120969 0,03423501 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of interleukin-12 biosynthetic process GO:0045075 10 8 0,000 0,01120969 0,034191 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,01120969 0,03414711 ! glycerolipid catabolic process GO:0046503 11 8 0,000 0,01120969 0,03410333 ! positive regulation of chemokine biosynthetic process GO:0045080 9 8 0,000 0,01120969 0,03405967 ! hemoglobin metabolic process GO:0020027 12 8 0,000 0,01120969 0,03401611 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,01120969 0,03397267 ! nerve growth factor receptor signaling pathway GO:0048011 12 8 0,000 0,01120969 0,03392934 ! insulin-like growth factor receptor signaling pathway GO:0048009 16 8 0,000 0,01120969 0,03388612 ! adrenal gland development GO:0030325 18 8 0,000 0,01120969 0,033843 ! embryonic cranial skeleton morphogenesis GO:0048701 12 8 0,000 0,01120969 0,0338 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,01120969 0,03375711 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,01120969 0,03371432 ! proline metabolic process GO:0006560 9 8 0,000 0,01120969 0,03367165 ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,01120969 0,03362908 ! regulation of interleukin-8 biosynthetic process GO:0045414 10 8 0,000 0,01120969 0,03358662 ! regulation of pigmentation during development GO:0048070 18 8 0,000 0,01120969 0,03354426 ! central nervous system neuron axonogenesis GO:0021955 16 8 0,000 0,01120969 0,03350202 GO:0021952|central nervous system projection neuron axonogenesis, ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 15 8 0,000 0,01120969 0,03345987 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,01120969 0,03341784 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,01120969 0,03337591 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of activated T cell proliferation GO:0042104 19 8 0,000 0,01120969 0,03333409 ! galactose metabolic process GO:0006012 14 8 0,000 0,01120969 0,03329237 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,01120969 0,03325075 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01120969 0,03320924 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,01120969 0,03316783 ! neurotransmitter catabolic process GO:0042135 16 8 0,000 0,01120969 0,03312653 ! ruffle organization GO:0031529 12 8 0,000 0,01120969 0,03308532 ! osteoblast development GO:0002076 14 8 0,000 0,01120969 0,03304422 ! macroautophagy GO:0016236 14 8 0,000 0,01120969 0,03300323 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,01120969 0,03296233 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,01120969 0,03292154 ! regulation of Notch signaling pathway GO:0008593 22 8 0,000 0,01120969 0,03288084 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,01120969 0,03284025 GO:0030204|chondroitin sulfate metabolic process, ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 14 8 0,000 0,01120969 0,03279975 ! G1 DNA damage checkpoint GO:0031571 19 8 0,000 0,01120969 0,03275936 ! protein retention in ER lumen GO:0006621 16 8 0,000 0,01120969 0,03271907 ! cardiac muscle cell differentiation GO:0055007 12 8 0,000 0,01120969 0,03267887 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 8 0,000 0,01120969 0,03263877 ! regulation of circadian rhythm GO:0042752 13 8 0,000 0,01120969 0,03259877 ! pigment granule localization GO:0051875 14 8 0,000 0,01120969 0,03255887 ! positive regulation of cytokine production during immune response GO:0002720 12 8 0,000 0,01120969 0,03251907 ! antigen processing and presentation of endogenous antigen GO:0019883 14 8 0,000 0,01120969 0,03247937 ! response to tropane GO:0014073 14 8 0,000 0,01120969 0,03243976 GO:0042220|response to cocaine, ! positive regulation of systemic arterial blood pressure GO:0003084 12 8 0,000 0,01120969 0,03240024 ! embryonic axis specification GO:0000578 12 8 0,000 0,01120969 0,03236083 ! negative regulation of interferon-gamma production GO:0032689 12 8 0,000 0,01120969 0,03232151 ! negative regulation of systemic arterial blood pressure GO:0003085 18 8 0,000 0,01120969 0,03228228 ! sphingomyelin metabolic process GO:0006684 11 8 0,000 0,01120969 0,03224315 ! snRNA metabolic process GO:0016073 10 8 0,000 0,01120969 0,03220412 GO:0016180|snRNA processing, ! nucleoside diphosphate metabolic process GO:0009132 9 8 0,000 0,01120969 0,03216518 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,01120969 0,03212633 ! regulation of mitochondrial membrane potential GO:0051881 14 8 0,000 0,01120969 0,03208758 ! regulation of interleukin-10 production GO:0032653 12 8 0,000 0,01120969 0,03204892 ! positive regulation of monooxygenase activity GO:0032770 12 8 0,000 0,01120969 0,03201035 ! protein import into peroxisome matrix GO:0016558 15 8 0,000 0,01120969 0,03197188 ! establishment of nucleus localization GO:0040023 14 8 0,000 0,01120969 0,03193349 ! icosanoid secretion GO:0032309 12 8 0,000 0,01120969 0,0318952 GO:0050482|arachidonic acid secretion, ! intracellular lipid transport GO:0032365 14 8 0,000 0,01120969 0,03185701 ! regulation of transcription from RNA polymerase III promoter GO:0006359 11 8 0,000 0,01120969 0,0318189 ! negative regulation of oxidoreductase activity GO:0051354 13 8 0,000 0,01120969 0,03178088 ! positive regulation of interleukin-1 beta secretion GO:0050718 10 8 0,000 0,01120969 0,03174296 ! regulation of T-helper 1 type immune response GO:0002825 10 8 0,000 0,01120969 0,03170513 ! S phase GO:0051320 8 8 0,000 0,01120969 0,03166738 GO:0000084|S phase of mitotic cell cycle, ! negative regulation of neuroblast proliferation GO:0007406 25 8 0,000 0,01120969 0,03162973 ! regulation of macrophage differentiation GO:0045649 15 8 0,000 0,01120969 0,03159216 ! negative regulation of osteoclast differentiation GO:0045671 12 8 0,000 0,01120969 0,03155469 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,01120969 0,0315173 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 8 0,000 0,01120969 0,03148 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,01120969 0,03144279 ! melanin biosynthetic process GO:0042438 11 8 0,000 0,01120969 0,03140567 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,01120969 0,03136863 ! regulation of synaptogenesis GO:0051963 12 8 0,000 0,01120969 0,03133168 ! hormone catabolic process GO:0042447 13 8 0,000 0,01120969 0,03129482 ! nicotinamide nucleotide biosynthetic process GO:0019359 12 8 0,000 0,01120969 0,03125805 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,01120969 0,03122136 ! positive regulation of ATPase activity GO:0032781 16 8 0,000 0,01120969 0,03118476 ! trophectodermal cell differentiation GO:0001829 10 8 0,000 0,01120969 0,03114824 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,01120969 0,03111181 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,01120969 0,03107547 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,01120969 0,03103921 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 8 8 0,000 0,01120969 0,03100303 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,01120969 0,03096694 ! B cell receptor signaling pathway GO:0050853 14 8 0,000 0,01120969 0,03093093 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 15 8 0,000 0,01120969 0,03089501 ! behavioral response to nicotine GO:0035095 13 8 0,000 0,01120969 0,03085917 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,01120969 0,03082341 GO:0000076|DNA replication checkpoint, ! fusion of sperm to egg plasma membrane GO:0007342 9 8 0,000 0,01120969 0,03078773 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 16 8 0,000 0,01120969 0,03075214 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 14 8 0,000 0,01120969 0,03071663 ! regulation of microtubule polymerization GO:0031113 14 8 0,000 0,01120969 0,0306812 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,01260235 0,03445321 ! regulation of developmental growth GO:0048638 14 9 0,000 0,01260235 0,03441357 ! negative regulation of smooth muscle cell proliferation GO:0048662 15 9 0,000 0,01260235 0,03437401 ! telencephalon cell migration GO:0022029 16 9 0,000 0,01260235 0,03433454 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 9 0,000 0,01260235 0,03429517 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 11 9 0,000 0,01260235 0,03425589 ! negative regulation of lipid biosynthetic process GO:0051055 13 9 0,000 0,01260235 0,03421669 ! glycerol-3-phosphate metabolic process GO:0006072 11 9 0,000 0,01260235 0,03417759 ! regulation of cellular amine metabolic process GO:0033238 12 9 0,000 0,01260235 0,03413857 ! cell volume homeostasis GO:0006884 14 9 0,000 0,01260235 0,03409964 ! regulation of epidermal growth factor receptor activity GO:0007176 14 9 0,000 0,01260235 0,03406081 GO:0010469|regulation of receptor activity, ! regulation of smooth muscle cell migration GO:0014910 22 9 0,000 0,01260235 0,03402206 ! UTP metabolic process GO:0046051 10 9 0,000 0,01260235 0,0339834 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! prostaglandin biosynthetic process GO:0001516 15 9 0,000 0,01260235 0,03394482 GO:0046457|prostanoid biosynthetic process, ! succinate metabolic process GO:0006105 16 9 0,000 0,01260235 0,03390634 ! smoothened signaling pathway GO:0007224 10 9 0,000 0,01260235 0,03386794 ! protein complex disassembly GO:0043241 17 9 0,000 0,01260235 0,03382962 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,01260235 0,0337914 ! estrogen metabolic process GO:0008210 16 9 0,000 0,01260235 0,03375326 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,01260235 0,03371521 ! cytoplasmic sequestering of transcription factor GO:0042994 12 9 0,000 0,01260235 0,03367724 ! negative regulation of muscle cell differentiation GO:0051148 10 9 0,000 0,01260235 0,03363936 ! microtubule bundle formation GO:0001578 14 9 0,000 0,01260235 0,03360156 ! T-helper 1 type immune response GO:0042088 13 9 0,000 0,01260235 0,03356385 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 22 9 0,000 0,01260235 0,03352622 ! lung alveolus development GO:0048286 18 9 0,000 0,01260235 0,03348868 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,01260235 0,03345122 ! pseudouridine synthesis GO:0001522 10 9 0,000 0,01260235 0,03341384 ! endothelial cell differentiation GO:0045446 17 9 0,000 0,01260235 0,03337655 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,01260235 0,03333934 ! endoderm development GO:0007492 12 9 0,000 0,01260235 0,03330221 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,01260235 0,03326517 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,01260235 0,03322821 ! myeloid leukocyte mediated immunity GO:0002444 12 9 0,000 0,01260235 0,03319133 ! astrocyte differentiation GO:0048708 17 9 0,000 0,01260235 0,03315453 ! L-phenylalanine metabolic process GO:0006558 11 9 0,000 0,01260235 0,03311782 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 10 9 0,000 0,01260235 0,03308118 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,01260235 0,03304463 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 13 9 0,000 0,01260235 0,03300815 ! reverse cholesterol transport GO:0043691 17 9 0,000 0,01260235 0,03297176 ! indolalkylamine metabolic process GO:0006586 15 9 0,000 0,01260235 0,03293545 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! melanin metabolic process GO:0006582 15 9 0,000 0,01260235 0,03289922 ! embryonic eye morphogenesis GO:0048048 15 9 0,000 0,01260235 0,03286306 ! macrophage activation GO:0042116 14 9 0,000 0,01260235 0,03282699 ! multicellular organism growth GO:0035264 16 9 0,000 0,01260235 0,032791 ! retrograde transport, endosome to Golgi GO:0042147 14 9 0,000 0,01260235 0,03275508 ! positive regulation of calcium ion transport into cytosol GO:0010524 13 9 0,000 0,01260235 0,03271924 ! lens development in camera-type eye GO:0002088 11 9 0,000 0,01260235 0,03268348 ! positive regulation of vasodilation GO:0045909 14 9 0,000 0,01260235 0,0326478 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,01260235 0,0326122 ! positive regulation of muscle contraction GO:0045933 13 9 0,000 0,01260235 0,03257668 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,01260235 0,03254123 ! regulation of smoothened signaling pathway GO:0008589 15 9 0,000 0,01260235 0,03250586 ! Schwann cell differentiation GO:0014037 20 9 0,000 0,01260235 0,03247056 ! acyl-CoA metabolic process GO:0006637 14 9 0,000 0,01260235 0,03243535 ! regulation of gliogenesis GO:0014013 21 9 0,000 0,01260235 0,0324002 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 21 9 0,000 0,01260235 0,03236514 ! oligodendrocyte development GO:0014003 13 9 0,000 0,01260235 0,03233015 ! alpha-beta T cell differentiation GO:0046632 15 9 0,000 0,01260235 0,03229524 ! segment specification GO:0007379 11 9 0,000 0,01260235 0,0322604 ! cellular extravasation GO:0045123 12 9 0,000 0,01260235 0,03222563 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,01260235 0,03219095 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 13 9 0,000 0,01260235 0,03215633 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,01260235 0,03212179 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,01260235 0,03208733 ! antigen processing and presentation of exogenous antigen GO:0019884 11 9 0,000 0,01260235 0,03205293 ! positive regulation of production of molecular mediator of immune response GO:0002702 13 9 0,000 0,01260235 0,03201862 ! purine nucleoside triphosphate catabolic process GO:0009146 13 9 0,000 0,01260235 0,03198437 ! regulation of T cell differentiation in the thymus GO:0033081 14 9 0,000 0,01260235 0,0319502 ! response to amine stimulus GO:0014075 13 9 0,000 0,01260235 0,0319161 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of protein kinase B signaling cascade GO:0051896 16 9 0,000 0,01260235 0,03188208 ! erythrocyte development GO:0048821 13 9 0,000 0,01260235 0,03184812 ! renal water homeostasis GO:0003091 13 9 0,000 0,01260235 0,03181424 ! positive regulation of tumor necrosis factor production GO:0032760 10 9 0,000 0,01260235 0,03178043 ! nucleosome disassembly GO:0006337 13 9 0,000 0,01260235 0,0317467 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! spinal cord motor neuron differentiation GO:0021522 12 9 0,000 0,01260235 0,03171303 ! transcription from RNA polymerase I promoter GO:0006360 14 9 0,000 0,01260235 0,03167944 ! induction of an organ GO:0001759 13 9 0,000 0,01260235 0,03164591 ! leukocyte activation during immune response GO:0002366 15 9 0,000 0,01260235 0,03161246 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 11 9 0,000 0,01260235 0,03157908 ! cerebellum morphogenesis GO:0021587 13 9 0,000 0,01260235 0,03154577 GO:0021696|cerebellar cortex morphogenesis, ! retinal ganglion cell axon guidance GO:0031290 11 9 0,000 0,01260235 0,03151253 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,01260235 0,03147936 ! sterol catabolic process GO:0016127 11 9 0,000 0,01260235 0,03144625 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 18 9 0,000 0,01260235 0,03141322 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,01260235 0,03138026 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 14 9 0,000 0,01260235 0,03134737 ! positive regulation of interleukin-1 secretion GO:0050716 11 9 0,000 0,01260235 0,03131454 ! cellular metabolic compound salvage GO:0043094 12 9 0,000 0,01260235 0,03128179 ! negative regulation of cytokine secretion GO:0050710 13 9 0,000 0,01260235 0,0312491 ! prophase GO:0051324 12 9 0,000 0,01260235 0,03121648 ! neuroblast proliferation GO:0007405 19 9 0,000 0,01260235 0,03118393 ! peptidyl-threonine modification GO:0018210 22 9 0,000 0,01260235 0,03115145 ! regulation of interleukin-1 beta secretion GO:0050706 12 9 0,000 0,01260235 0,03111903 ! ubiquinone metabolic process GO:0006743 11 9 0,000 0,01260235 0,03108668 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of erythrocyte differentiation GO:0045648 20 9 0,000 0,01260235 0,0310544 ! acid secretion GO:0046717 14 9 0,000 0,01260235 0,03102219 ! purine base metabolic process GO:0006144 18 9 0,000 0,01260235 0,03099004 ! detection of calcium ion GO:0005513 13 9 0,000 0,01260235 0,03095796 ! myeloid cell homeostasis GO:0002262 10 9 0,000 0,01260235 0,03092594 ! regulation of fibrinolysis GO:0051917 14 9 0,000 0,01260235 0,030894 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,01260235 0,03086211 ! natural killer cell mediated immunity GO:0002228 14 9 0,000 0,01260235 0,0308303 GO:0042267|natural killer cell mediated cytotoxicity, ! negative regulation of blood vessel endothelial cell migration GO:0043537 18 9 0,000 0,01260235 0,03079855 ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,01260235 0,03076686 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,01260235 0,03073524 ! defense response to Gram-positive bacterium GO:0050830 11 9 0,000 0,01260235 0,03070368 ! prepulse inhibition GO:0060134 14 9 0,000 0,01260235 0,03067219 ! sequestering of metal ion GO:0051238 12 9 0,000 0,01260235 0,03064077 ! lamellipodium assembly GO:0030032 12 9 0,000 0,01260235 0,0306094 ! regulation of embryonic development GO:0045995 17 9 0,000 0,01260235 0,03057811 ! mitochondrion localization GO:0051646 15 9 0,000 0,01260235 0,03054687 ! localization within membrane GO:0051668 15 9 0,000 0,01260235 0,0305157 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,01399313 0,03384882 ! axon extension GO:0048675 13 10 0,000 0,01399313 0,03381435 ! neuron fate specification GO:0048665 12 10 0,000 0,01399313 0,03377995 ! regulation of epithelial cell differentiation GO:0030856 20 10 0,000 0,01399313 0,03374562 ! cortical actin cytoskeleton organization GO:0030866 24 10 0,000 0,01399313 0,03371136 ! associative learning GO:0008306 19 10 0,000 0,01399313 0,03367717 ! cellular copper ion homeostasis GO:0006878 14 10 0,000 0,01399313 0,03364305 ! CTP metabolic process GO:0046036 11 10 0,000 0,01399313 0,033609 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 17 10 0,000 0,01399313 0,03357501 ! GTP metabolic process GO:0046039 11 10 0,000 0,01399313 0,0335411 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,01399313 0,03350725 GO:0007520|myoblast fusion, ! actin-myosin filament sliding GO:0033275 14 10 0,000 0,01399313 0,03347348 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,01399313 0,03343977 ! social behavior GO:0035176 15 10 0,000 0,01399313 0,03340612 ! sulfate transport GO:0008272 12 10 0,000 0,01399313 0,03337255 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 19 10 0,000 0,01399313 0,03333904 ! artery development GO:0060840 20 10 0,000 0,01399313 0,0333056 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 13 10 0,000 0,01399313 0,03327223 ! response to pain GO:0048265 20 10 0,000 0,01399313 0,03323893 ! COPI coating of Golgi vesicle GO:0048205 15 10 0,000 0,01399313 0,03320569 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,01399313 0,03317252 ! phospholipid efflux GO:0033700 17 10 0,000 0,01399313 0,03313941 ! hippocampus development GO:0021766 19 10 0,000 0,01399313 0,03310637 ! positive regulation of transcription factor import into nucleus GO:0042993 21 10 0,000 0,01399313 0,03307339 ! amyloid precursor protein metabolic process GO:0042982 16 10 0,000 0,01399313 0,03304049 ! blood vessel remodeling GO:0001974 23 10 0,000 0,01399313 0,03300764 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,01399313 0,03297486 ! pathogenesis GO:0009405 13 10 0,000 0,01399313 0,03294215 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,01399313 0,0329095 ! two-component signal transduction system (phosphorelay) GO:0000160 15 10 0,000 0,01399313 0,03287692 ! negative regulation of striated muscle development GO:0045843 13 10 0,000 0,01399313 0,0328444 ! protein targeting to ER GO:0045047 21 10 0,000 0,01399313 0,03281194 ! regulation of S phase of mitotic cell cycle GO:0007090 19 10 0,000 0,01399313 0,03277955 ! arginine catabolic process GO:0006527 12 10 0,000 0,01399313 0,03274723 ! melanocyte differentiation GO:0030318 16 10 0,000 0,01399313 0,03271496 GO:0050931|pigment cell differentiation, ! telomere maintenance via telomerase GO:0007004 14 10 0,000 0,01399313 0,03268276 GO:0010833|telomere maintenance via telomere lengthening, ! polyamine metabolic process GO:0006595 14 10 0,000 0,01399313 0,03265063 ! positive regulation of endothelial cell migration GO:0010595 20 10 0,000 0,01399313 0,03261855 ! B cell proliferation GO:0042100 16 10 0,000 0,01399313 0,03258654 ! nucleobase biosynthetic process GO:0046112 20 10 0,000 0,01399313 0,0325546 ! mannose metabolic process GO:0006013 11 10 0,000 0,01399313 0,03252271 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,01399313 0,03249089 ! forebrain cell migration GO:0021885 17 10 0,000 0,01399313 0,03245913 ! lipid digestion GO:0044241 15 10 0,000 0,01399313 0,03242743 ! substrate-bound cell migration GO:0006929 11 10 0,000 0,01399313 0,03239579 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,01399313 0,03236422 ! receptor clustering GO:0043113 18 10 0,000 0,01399313 0,0323327 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,01399313 0,03230125 ! UV protection GO:0009650 14 10 0,000 0,01399313 0,03226986 ! entry into host cell GO:0030260 21 10 0,000 0,01399313 0,03223853 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! regulation of lipoprotein lipase activity GO:0051004 20 10 0,000 0,01399313 0,03220726 ! behavioral fear response GO:0001662 19 10 0,000 0,01399313 0,03217605 GO:0002209|behavioral defense response, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,01399313 0,03214491 ! negative regulation of ossification GO:0030279 21 10 0,000 0,01399313 0,03211382 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 23 10 0,000 0,01399313 0,03208279 ! protein homotetramerization GO:0051289 20 10 0,000 0,01399313 0,03205182 ! positive regulation of peptide secretion GO:0002793 16 10 0,000 0,01399313 0,03202091 ! response to dsRNA GO:0043331 19 10 0,000 0,01399313 0,03199007 ! DNA ligation GO:0006266 16 10 0,000 0,01399313 0,03195928 ! phosphoinositide 3-kinase cascade GO:0014065 26 10 0,000 0,01399313 0,03192855 ! regulation of interleukin-4 production GO:0032673 18 10 0,000 0,01399313 0,03189787 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,01399313 0,03186726 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,01399313 0,03183671 ! postreplication repair GO:0006301 16 10 0,000 0,01399313 0,03180621 ! fucose catabolic process GO:0019317 17 10 0,000 0,01399313 0,03177578 GO:0042355|L-fucose catabolic process, ! mRNA cleavage GO:0006379 14 10 0,000 0,01399313 0,0317454 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,01399313 0,03171508 ! hindbrain morphogenesis GO:0021575 16 10 0,000 0,01399313 0,03168482 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 10 0,000 0,01399313 0,03165461 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 13 10 0,000 0,01399313 0,03162446 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,01399313 0,03159437 ! positive regulation of neuron differentiation GO:0045666 13 10 0,000 0,01399313 0,03156434 ! positive regulation of leukocyte migration GO:0002687 24 10 0,000 0,01399313 0,03153437 ! multicellular organismal water homeostasis GO:0050891 14 10 0,000 0,01399313 0,03150445 ! negative regulation of lymphocyte differentiation GO:0045620 13 10 0,000 0,01399313 0,03147459 ! methionine biosynthetic process GO:0009086 13 10 0,000 0,01399313 0,03144478 ! oocyte differentiation GO:0009994 14 10 0,000 0,01399313 0,03141503 GO:0048599|oocyte development, ! pyridine nucleotide biosynthetic process GO:0019363 14 10 0,000 0,01399313 0,03138534 ! spleen development GO:0048536 17 10 0,000 0,01399313 0,0313557 ! negative regulation of BMP signaling pathway GO:0030514 15 10 0,000 0,01399313 0,03132612 ! regulation of RNA splicing GO:0043484 15 10 0,000 0,01399313 0,0312966 ! positive regulation of viral reproduction GO:0048524 14 10 0,000 0,01399313 0,03126713 ! blastocyst formation GO:0001825 14 10 0,000 0,01399313 0,03123771 ! embryonic gut development GO:0048566 13 10 0,000 0,01399313 0,03120835 ! quinone cofactor metabolic process GO:0042375 12 10 0,000 0,01399313 0,03117905 ! cerebellar cortex development GO:0021695 14 10 0,000 0,01399313 0,0311498 ! activation of innate immune response GO:0002218 10 10 0,000 0,01399313 0,03112061 GO:0002758|innate immune response-activating signal transduction, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,01399313 0,03109147 ! insulin secretion GO:0030073 18 10 0,000 0,01399313 0,03106238 ! cytoplasmic sequestering of protein GO:0051220 15 10 0,000 0,01399313 0,03103335 ! response to nicotine GO:0035094 18 10 0,000 0,01399313 0,03100438 ! nucleus localization GO:0051647 16 10 0,000 0,01399313 0,03097545 ! regulation of synapse organization GO:0050807 14 10 0,000 0,01399313 0,03094659 ! negative regulation of muscle development GO:0048635 14 11 0,000 0,01538201 0,0339865 ! positive regulation of glucose metabolic process GO:0010907 17 11 0,000 0,01538201 0,03395489 ! ER-associated protein catabolic process GO:0030433 17 11 0,000 0,01538201 0,03392333 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! negative regulation of blood pressure GO:0045776 25 11 0,000 0,01538201 0,03389183 ! cortical cytoskeleton organization GO:0030865 25 11 0,000 0,01538201 0,03386039 ! virus-host interaction GO:0019048 20 11 0,000 0,01538201 0,03382901 ! thyroid gland development GO:0030878 20 11 0,000 0,01538201 0,03379769 ! pentose-phosphate shunt GO:0006098 14 11 0,000 0,01538201 0,03376642 GO:0006740|NADPH regeneration, ! non-recombinational repair GO:0000726 19 11 0,000 0,01538201 0,03373522 GO:0006303|double-strand break repair via nonhomologous end joining, ! synapsis GO:0007129 15 11 0,000 0,01538201 0,03370407 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 11 11 0,000 0,01538201 0,03367297 ! elastic fiber assembly GO:0048251 17 11 0,000 0,01538201 0,03364194 ! regulation of positive chemotaxis GO:0050926 19 11 0,000 0,01538201 0,03361096 GO:0050927|positive regulation of positive chemotaxis, ! regulation of glycolysis GO:0006110 18 11 0,000 0,01538201 0,03358004 ! dopamine receptor signaling pathway GO:0007212 25 11 0,000 0,01538201 0,03354918 ! regulation of cell projection assembly GO:0060491 22 11 0,000 0,01538201 0,03351837 ! positive regulation of lipid metabolic process GO:0045834 15 11 0,000 0,01538201 0,03348762 ! bone resorption GO:0045453 16 11 0,000 0,01538201 0,03345692 ! regulation of chemokine biosynthetic process GO:0045073 13 11 0,000 0,01538201 0,03342629 ! peptide or protein amino-terminal blocking GO:0018409 16 11 0,000 0,01538201 0,0333957 ! ventral spinal cord development GO:0021517 15 11 0,000 0,01538201 0,03336518 ! regulated secretory pathway GO:0045055 15 11 0,000 0,01538201 0,03333471 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 19 11 0,000 0,01538201 0,03330429 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! regulation of catecholamine secretion GO:0050433 21 11 0,000 0,01538201 0,03327393 ! syncytium formation GO:0006949 15 11 0,000 0,01538201 0,03324363 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,01538201 0,03321338 ! glucan biosynthetic process GO:0009250 14 11 0,000 0,01538201 0,03318319 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 16 11 0,000 0,01538201 0,03315305 ! Golgi organization GO:0007030 19 11 0,000 0,01538201 0,03312296 ! response to X-ray GO:0010165 19 11 0,000 0,01538201 0,03309293 ! retinoic acid receptor signaling pathway GO:0048384 16 11 0,000 0,01538201 0,03306296 ! adult heart development GO:0007512 12 11 0,000 0,01538201 0,03303304 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,01538201 0,03300317 ! epithelial cell development GO:0002064 16 11 0,000 0,01538201 0,03297336 ! actin cytoskeleton reorganization GO:0031532 20 11 0,000 0,01538201 0,0329436 ! temperature homeostasis GO:0001659 16 11 0,000 0,01538201 0,03291389 ! L-glutamate transport GO:0015813 15 11 0,000 0,01538201 0,03288424 GO:0015800|acidic amino acid transport, ! positive regulation vascular endothelial growth factor production GO:0010575 19 11 0,000 0,01538201 0,03285464 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,01538201 0,03282509 ! motor axon guidance GO:0008045 17 11 0,000 0,01538201 0,0327956 ! copper ion homeostasis GO:0055070 15 11 0,000 0,01538201 0,03276616 ! protein targeting to peroxisome GO:0006625 21 11 0,000 0,01538201 0,03273677 ! regulation of bone resorption GO:0045124 27 11 0,000 0,01538201 0,03270744 ! stem cell development GO:0048864 30 11 0,000 0,01538201 0,03267816 GO:0019827|stem cell maintenance, ! alpha-beta T cell activation GO:0046631 18 11 0,000 0,01538201 0,03264893 ! negative regulation of axonogenesis GO:0050771 26 11 0,000 0,01538201 0,03261975 ! regulation of phagocytosis GO:0050764 16 11 0,000 0,01538201 0,03259063 ! regulation of insulin receptor signaling pathway GO:0046626 17 11 0,000 0,01538201 0,03256156 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,01538201 0,03253253 ! nucleoside triphosphate catabolic process GO:0009143 16 11 0,000 0,01538201 0,03250357 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,01538201 0,03247465 ! synaptic vesicle exocytosis GO:0016079 16 11 0,000 0,01538201 0,03244578 ! regulation of B cell differentiation GO:0045577 23 11 0,000 0,01538201 0,03241697 ! cranial nerve development GO:0021545 14 11 0,000 0,01538201 0,0323882 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,01538201 0,03235949 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,01538201 0,03233083 ! salivary gland development GO:0007431 24 11 0,000 0,01538201 0,03230222 ! negative regulation of neurological system process GO:0031645 20 11 0,000 0,01538201 0,03227366 ! regulation of leukocyte migration GO:0002685 25 11 0,000 0,01538201 0,03224514 ! musculoskeletal movement GO:0050881 16 11 0,000 0,01538201 0,03221668 GO:0050879|multicellular organismal movement, ! nitric oxide mediated signal transduction GO:0007263 20 11 0,000 0,01538201 0,03218828 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,01538201 0,03215992 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,01538201 0,03213161 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 19 11 0,000 0,01538201 0,03210335 ! cholesterol efflux GO:0033344 20 11 0,000 0,01538201 0,03207514 ! digestive tract morphogenesis GO:0048546 16 11 0,000 0,01538201 0,03204697 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 23 11 0,000 0,01538201 0,03201886 ! thyroid hormone metabolic process GO:0042403 17 11 0,000 0,01538201 0,0319908 ! leukocyte mediated cytotoxicity GO:0001909 18 11 0,000 0,01538201 0,03196279 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,01538201 0,03193482 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 21 11 0,000 0,01538201 0,03190691 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,01538201 0,03187904 ! cardiac cell differentiation GO:0035051 18 11 0,000 0,01538201 0,03185123 ! defense response to fungus GO:0050832 13 11 0,000 0,01538201 0,03182346 ! lysogeny GO:0030069 20 11 0,000 0,01538201 0,03179574 GO:0019047|provirus integration, ! T cell receptor signaling pathway GO:0050852 22 11 0,000 0,01538201 0,03176806 ! acrosome reaction GO:0007340 14 11 0,000 0,01538201 0,03174044 ! regulation of synapse structure and activity GO:0050803 15 11 0,000 0,01538201 0,03171286 ! regulation of steroid biosynthetic process GO:0050810 13 11 0,000 0,01538201 0,03168533 ! rRNA transcription GO:0009303 19 12 0,000 0,016769 0,03451244 ! reproductive cellular process GO:0048610 15 12 0,000 0,016769 0,03448253 ! regulation of membrane protein ectodomain proteolysis GO:0051043 17 12 0,000 0,016769 0,03445268 ! pteridine and derivative biosynthetic process GO:0042559 15 12 0,000 0,016769 0,03442288 ! dicarboxylic acid transport GO:0006835 21 12 0,000 0,016769 0,03439312 ! phosphate transport GO:0006817 15 12 0,000 0,016769 0,03436342 ! peroxisomal transport GO:0043574 22 12 0,000 0,016769 0,03433377 ! mating GO:0007618 16 12 0,000 0,016769 0,03430418 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,016769 0,03427463 ! heart looping GO:0001947 15 12 0,000 0,016769 0,03424513 ! negative regulation of cell-matrix adhesion GO:0001953 31 12 0,000 0,016769 0,03421569 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 20 12 0,000 0,016769 0,03418629 ! negative regulation of proteolysis GO:0045861 17 12 0,000 0,016769 0,03415695 ! T cell selection GO:0045058 25 12 0,000 0,016769 0,03412765 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,016769 0,03409841 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 17 12 0,000 0,016769 0,03406922 ! oligodendrocyte differentiation GO:0048709 19 12 0,000 0,016769 0,03404007 ! plasma membrane organization GO:0007009 19 12 0,000 0,016769 0,03401098 ! focal adhesion formation GO:0048041 28 12 0,000 0,016769 0,03398193 ! mitotic spindle organization GO:0007052 16 12 0,000 0,016769 0,03395294 ! cellular carbohydrate catabolic process GO:0044275 14 12 0,000 0,016769 0,03392399 ! regulation of intracellular pH GO:0051453 19 12 0,000 0,016769 0,0338951 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,016769 0,03386625 ! monoamine transport GO:0015844 14 12 0,000 0,016769 0,03383745 ! regulation of vascular endothelial growth factor production GO:0010574 20 12 0,000 0,016769 0,0338087 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 18 12 0,000 0,016769 0,03378 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,016769 0,03375135 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,016769 0,03372275 ! regulation of organ growth GO:0046620 14 12 0,000 0,016769 0,03369419 ! vasoconstriction GO:0042310 18 12 0,000 0,016769 0,03366569 ! RNA-dependent DNA replication GO:0006278 16 12 0,000 0,016769 0,03363723 ! regulation of interleukin-8 production GO:0032677 19 12 0,000 0,016769 0,03360882 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,016769 0,03358046 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,016769 0,03355214 ! histone deacetylation GO:0016575 14 12 0,000 0,016769 0,03352388 ! histone acetylation GO:0016573 27 12 0,000 0,016769 0,03349566 ! DNA methylation GO:0006306 19 12 0,000 0,016769 0,03346749 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 19 12 0,000 0,016769 0,03343936 ! protein sumoylation GO:0016925 14 12 0,000 0,016769 0,03341129 ! chromatin silencing GO:0006342 23 12 0,000 0,016769 0,03338326 ! negative regulation of MAPKKK cascade GO:0043409 23 12 0,000 0,016769 0,03335528 ! gland morphogenesis GO:0022612 24 12 0,000 0,016769 0,03332734 ! regulation of hormone metabolic process GO:0032350 21 12 0,000 0,016769 0,03329945 ! zymogen activation GO:0031638 16 12 0,000 0,016769 0,03327161 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,016769 0,03324381 ! nucleosome positioning GO:0016584 13 12 0,000 0,016769 0,03321606 ! regulation of isotype switching GO:0045191 22 12 0,000 0,016769 0,03318836 ! glutathione biosynthetic process GO:0006750 14 12 0,000 0,016769 0,0331607 ! response to gamma radiation GO:0010332 21 12 0,000 0,016769 0,03313309 ! regulation of osteoclast differentiation GO:0045670 18 12 0,000 0,016769 0,03310553 ! regulation of T-helper 2 cell differentiation GO:0045628 19 12 0,000 0,016769 0,03307801 ! aromatic amino acid family catabolic process GO:0009074 16 12 0,000 0,016769 0,03305053 ! serine family amino acid biosynthetic process GO:0009070 16 12 0,000 0,016769 0,03302311 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,016769 0,03299572 ! male genitalia development GO:0030539 15 12 0,000 0,016769 0,03296839 ! regulation of cellular carbohydrate catabolic process GO:0043471 19 12 0,000 0,016769 0,0329411 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of fatty acid oxidation GO:0046320 20 12 0,000 0,016769 0,03291385 ! developmental induction GO:0031128 16 12 0,000 0,016769 0,03288665 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 15 12 0,000 0,016769 0,03285949 ! response to cold GO:0009409 15 12 0,000 0,016769 0,03283238 ! negative regulation of immune effector process GO:0002698 20 12 0,000 0,016769 0,03280531 ! respiratory burst GO:0045730 22 13 0,000 0,01815411 0,03548576 ! lactation GO:0007595 22 13 0,000 0,01815411 0,03545655 ! tRNA modification GO:0006400 15 13 0,000 0,01815411 0,03542739 ! negative regulation of cell projection organization GO:0031345 29 13 0,000 0,01815411 0,03539828 ! positive regulation of blood pressure GO:0045777 19 13 0,000 0,01815411 0,03536922 ! cGMP metabolic process GO:0046068 16 13 0,000 0,01815411 0,03534021 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 20 13 0,000 0,01815411 0,03531124 ! water transport GO:0006833 21 13 0,000 0,01815411 0,03528232 GO:0042044|fluid transport, ! regulation of nitric-oxide synthase activity GO:0050999 23 13 0,000 0,01815411 0,03525345 ! copper ion transport GO:0006825 15 13 0,000 0,01815411 0,03522462 ! filopodium assembly GO:0046847 21 13 0,000 0,01815411 0,03519584 ! lipid localization GO:0010876 25 13 0,000 0,01815411 0,03516711 GO:0019915|lipid storage, ! detection of mechanical stimulus GO:0050982 17 13 0,000 0,01815411 0,03513843 ! negative regulation of transcription factor import into nucleus GO:0042992 26 13 0,000 0,01815411 0,03510979 ! cytokine biosynthetic process GO:0042089 17 13 0,000 0,01815411 0,0350812 ! T cell proliferation GO:0042098 24 13 0,000 0,01815411 0,03505265 ! organelle fusion GO:0048284 29 13 0,000 0,01815411 0,03502416 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,01815411 0,0349957 ! endocrine pancreas development GO:0031018 19 13 0,000 0,01815411 0,0349673 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 24 13 0,000 0,01815411 0,03493894 ! platelet-derived growth factor receptor signaling pathway GO:0048008 20 13 0,000 0,01815411 0,03491063 ! photoreceptor cell maintenance GO:0045494 20 13 0,000 0,01815411 0,03488236 ! regulation of mRNA processing GO:0050684 21 13 0,000 0,01815411 0,03485414 ! regulation of skeletal muscle fiber development GO:0048742 22 13 0,000 0,01815411 0,03482596 ! methionine metabolic process GO:0006555 16 13 0,000 0,01815411 0,03479783 ! deoxyribonucleotide catabolic process GO:0009264 17 13 0,000 0,01815411 0,03476974 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,01815411 0,0347417 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cell-cell junction assembly GO:0007043 21 13 0,000 0,01815411 0,03471371 ! negative regulation of endothelial cell migration GO:0010596 22 13 0,000 0,01815411 0,03468576 ! membrane protein proteolysis GO:0033619 21 13 0,000 0,01815411 0,03465785 GO:0006509|membrane protein ectodomain proteolysis, ! fear response GO:0042596 22 13 0,000 0,01815411 0,03462999 ! neutral amino acid transport GO:0015804 20 13 0,000 0,01815411 0,03460218 ! negative regulation of mitotic cell cycle GO:0045930 32 13 0,000 0,01815411 0,03457441 ! regulation of natural killer cell mediated immunity GO:0002715 21 13 0,000 0,01815411 0,03454668 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 16 13 0,000 0,01815411 0,034519 ! positive regulation of protein import into nucleus GO:0042307 24 13 0,000 0,01815411 0,03449136 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,01815411 0,03446377 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,01815411 0,03443622 ! cellular pigmentation GO:0033059 24 13 0,000 0,01815411 0,03440872 ! histone methylation GO:0016571 16 13 0,000 0,01815411 0,03438125 ! regulation of epidermis development GO:0045682 21 13 0,000 0,01815411 0,03435384 ! oxygen transport GO:0015671 20 13 0,000 0,01815411 0,03432646 ! regulation of axon extension GO:0030516 26 13 0,000 0,01815411 0,03429913 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 24 13 0,000 0,01815411 0,03427185 ! detection of bacterium GO:0016045 13 13 0,000 0,01815411 0,0342446 ! L-fucose metabolic process GO:0042354 21 13 0,000 0,01815411 0,0342174 ! regulation of NF-kappaB import into nucleus GO:0042345 24 13 0,000 0,01815411 0,03419025 ! positive regulation of homeostatic process GO:0032846 19 13 0,000 0,01815411 0,03416313 ! positive regulation of protein polymerization GO:0032273 21 13 0,000 0,01815411 0,03413606 ! actin filament polymerization GO:0030041 18 13 0,000 0,01815411 0,03410904 ! N-terminal protein amino acid modification GO:0031365 20 14 0,000 0,01953734 0,03667889 ! positive regulation of cellular catabolic process GO:0031331 24 14 0,000 0,01953734 0,03664989 ! G1 phase of mitotic cell cycle GO:0000080 24 14 0,000 0,01953734 0,03662094 ! neuron maturation GO:0042551 24 14 0,000 0,01953734 0,03659204 ! regulation of S phase GO:0033261 25 14 0,000 0,01953734 0,03656318 ! regulation of chemokine production GO:0032642 18 14 0,000 0,01953734 0,03653437 ! myotube differentiation GO:0014902 21 14 0,000 0,01953734 0,0365056 ! double-strand break repair via homologous recombination GO:0000724 24 14 0,000 0,01953734 0,03647688 GO:0000725|recombinational repair, ! negative regulation of bone remodeling GO:0046851 28 14 0,000 0,01953734 0,0364482 ! phospholipid catabolic process GO:0009395 19 14 0,000 0,01953734 0,03641957 ! aminoglycan catabolic process GO:0006026 19 14 0,000 0,01953734 0,03639099 ! vesicle targeting, to, from or within Golgi GO:0048199 19 14 0,000 0,01953734 0,03636244 ! cardiac muscle contraction GO:0060048 28 14 0,000 0,01953734 0,03633395 ! RNA polyadenylation GO:0043631 21 14 0,000 0,01953734 0,03630549 ! cartilage condensation GO:0001502 22 14 0,000 0,01953734 0,03627709 ! gene silencing by RNA GO:0031047 22 14 0,000 0,01953734 0,03624872 ! response to cAMP GO:0051591 20 14 0,000 0,01953734 0,0362204 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 17 14 0,000 0,01953734 0,03619213 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 14 0,000 0,01953734 0,0361639 ! negative regulation of cytokine biosynthetic process GO:0042036 19 14 0,000 0,01953734 0,03613571 ! limbic system development GO:0021761 25 14 0,000 0,01953734 0,03610757 ! positive regulation of ion transport GO:0043270 18 14 0,000 0,01953734 0,03607947 GO:0051928|positive regulation of calcium ion transport, ! startle response GO:0001964 21 14 0,000 0,01953734 0,03605141 ! palate development GO:0060021 19 14 0,000 0,01953734 0,0360234 ! negative regulation of gene expression, epigenetic GO:0045814 30 14 0,000 0,01953734 0,03599543 ! negative regulation of protein amino acid phosphorylation GO:0001933 31 14 0,000 0,01953734 0,03596751 ! regulation of defense response to virus GO:0050688 26 14 0,000 0,01953734 0,03593962 ! response to hexose stimulus GO:0009746 22 14 0,000 0,01953734 0,03591179 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! epidermis morphogenesis GO:0048730 31 14 0,000 0,01953734 0,03588399 ! arginine metabolic process GO:0006525 17 14 0,000 0,01953734 0,03585624 ! glutamate metabolic process GO:0006536 21 14 0,000 0,01953734 0,03582853 ! glycine metabolic process GO:0006544 22 14 0,000 0,01953734 0,03580086 ! pituitary gland development GO:0021983 24 14 0,000 0,01953734 0,03577324 ! tyrosine metabolic process GO:0006570 20 14 0,000 0,01953734 0,03574566 ! negative regulation of microtubule depolymerization GO:0007026 34 14 0,000 0,01953734 0,03571812 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 21 14 0,000 0,01953734 0,03569062 ! cytokine metabolic process GO:0042107 18 14 0,000 0,01953734 0,03566317 ! NAD metabolic process GO:0019674 25 14 0,000 0,01953734 0,03563575 ! regulation of ion transmembrane transporter activity GO:0032412 19 14 0,000 0,01953734 0,03560838 ! regulation of heart rate GO:0002027 26 14 0,000 0,01953734 0,03558106 ! exocrine system development GO:0035272 29 14 0,000 0,01953734 0,03555377 ! positive regulation of carbohydrate metabolic process GO:0045913 22 14 0,000 0,01953734 0,03552653 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! purine nucleoside monophosphate metabolic process GO:0009126 22 14 0,000 0,01953734 0,03549932 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! cotranslational protein targeting to membrane GO:0006613 25 14 0,000 0,01953734 0,03547216 ! axon cargo transport GO:0008088 29 14 0,000 0,01953734 0,03544504 ! positive regulation of T cell mediated immunity GO:0002711 30 14 0,000 0,01953734 0,03541796 ! negative regulation of protein import into nucleus GO:0042308 27 14 0,000 0,01953734 0,03539093 ! genitalia development GO:0048806 18 14 0,000 0,01953734 0,03536393 ! regulation of interleukin-12 production GO:0032655 20 14 0,000 0,01953734 0,03533698 ! autonomic nervous system development GO:0048483 26 14 0,000 0,01953734 0,03531007 ! tissue regeneration GO:0042246 24 14 0,000 0,01953734 0,03528319 ! negative regulation of protein secretion GO:0050709 22 14 0,000 0,01953734 0,03525636 ! water homeostasis GO:0030104 23 14 0,000 0,01953734 0,03522957 ! cofactor transport GO:0051181 22 14 0,000 0,01953734 0,03520282 ! regulation of acute inflammatory response GO:0002673 21 14 0,000 0,01953734 0,03517611 ! positive regulation of T-helper cell differentiation GO:0045624 20 14 0,000 0,01953734 0,03514944 ! glutamine family amino acid biosynthetic process GO:0009084 16 14 0,000 0,01953734 0,03512281 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,01953734 0,03509623 ! regulation of mRNA stability GO:0043488 30 14 0,000 0,01953734 0,03506968 ! cell killing GO:0001906 22 14 0,000 0,01953734 0,03504317 ! positive regulation of JNK cascade GO:0046330 22 14 0,000 0,01953734 0,0350167 ! epithelial to mesenchymal transition GO:0001837 24 14 0,000 0,01953734 0,03499028 ! mRNA 3'-end processing GO:0031124 21 14 0,000 0,01953734 0,03496389 ! microspike assembly GO:0030035 25 14 0,000 0,01953734 0,03493754 ! positive regulation of calcium-mediated signaling GO:0050850 27 14 0,000 0,01953734 0,03491123 ! regulation of skeletal muscle tissue development GO:0048641 24 15 0,000 0,02091869 0,03735144 ! superoxide anion generation GO:0042554 19 15 0,000 0,02091869 0,03732335 ! negative regulation of hormone secretion GO:0046888 22 15 0,000 0,02091869 0,03729531 ! embryonic hindlimb morphogenesis GO:0035116 28 15 0,000 0,02091869 0,03726731 ! embryonic forelimb morphogenesis GO:0035115 18 15 0,000 0,02091869 0,03723935 ! inositol metabolic process GO:0006020 21 15 0,000 0,02091869 0,03721144 ! retina development in camera-type eye GO:0060041 22 15 0,000 0,02091869 0,03718357 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 22 15 0,000 0,02091869 0,03715573 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 25 15 0,000 0,02091869 0,03712794 ! regulation of transmembrane transporter activity GO:0022898 20 15 0,000 0,02091869 0,03710019 GO:0032409|regulation of transporter activity, ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,02091869 0,03707249 ! activation of MAPKK activity GO:0000186 22 15 0,000 0,02091869 0,03704482 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 18 15 0,000 0,02091869 0,0370172 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,02091869 0,03698961 ! response to osmotic stress GO:0006970 23 15 0,000 0,02091869 0,03696207 ! vesicle coating GO:0006901 26 15 0,000 0,02091869 0,03693457 ! regulation of the force of heart contraction GO:0002026 24 15 0,000 0,02091869 0,03690711 ! preassembly of GPI anchor in ER membrane GO:0016254 22 15 0,000 0,02091869 0,03687969 ! positive regulation of activation of JAK2 kinase activity GO:0010535 15 15 0,000 0,02091869 0,03685231 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 23 15 0,000 0,02091869 0,03682497 ! bone mineralization GO:0030282 17 15 0,000 0,02091869 0,03679767 ! G1/S transition checkpoint GO:0031575 36 15 0,000 0,02091869 0,03677041 ! intermediate filament cytoskeleton organization GO:0045104 27 15 0,000 0,02091869 0,0367432 ! positive regulation of axonogenesis GO:0050772 21 15 0,000 0,02091869 0,03671602 ! regulation of cytokine production during immune response GO:0002718 23 15 0,000 0,02091869 0,03668888 ! T cell differentiation in the thymus GO:0033077 30 15 0,000 0,02091869 0,03666179 ! regulation of cellular pH GO:0030641 23 15 0,000 0,02091869 0,03663473 ! ribosome assembly GO:0042255 17 15 0,000 0,02091869 0,03660771 ! cerebellum development GO:0021549 19 15 0,000 0,02091869 0,03658074 ! regulation of monooxygenase activity GO:0032768 29 15 0,000 0,02091869 0,0365538 ! mRNA splice site selection GO:0006376 33 15 0,000 0,02091869 0,0365269 ! positive regulation of cytokine secretion GO:0050715 19 15 0,000 0,02091869 0,03650004 ! regulation of T-helper 2 type immune response GO:0002828 24 15 0,000 0,02091869 0,03647323 ! negative regulation of inflammatory response GO:0050728 18 15 0,000 0,02091869 0,03644645 ! sphingolipid catabolic process GO:0030149 27 15 0,000 0,02091869 0,03641971 GO:0046466|membrane lipid catabolic process, ! positive regulation of bone mineralization GO:0030501 22 15 0,000 0,02091869 0,03639301 ! regulation of erythrocyte differentiation GO:0045646 29 15 0,000 0,02091869 0,03636634 ! muscle maintenance GO:0046716 21 15 0,000 0,02091869 0,03633972 ! C21-steroid hormone biosynthetic process GO:0006700 17 15 0,000 0,02091869 0,03631314 ! intestinal absorption GO:0050892 22 15 0,000 0,02091869 0,03628659 ! regulation of ATPase activity GO:0043462 24 15 0,000 0,02091869 0,03626009 ! dopamine metabolic process GO:0042417 32 15 0,000 0,02091869 0,03623362 ! gas transport GO:0015669 23 15 0,000 0,02091869 0,03620719 ! regulation of RNA stability GO:0043487 31 15 0,000 0,02091869 0,0361808 ! organic cation transport GO:0015695 19 15 0,000 0,02091869 0,03615445 ! heme biosynthetic process GO:0006783 22 15 0,000 0,02091869 0,03612814 ! regulation of BMP signaling pathway GO:0030510 24 15 0,000 0,02091869 0,03610186 ! aromatic compound biosynthetic process GO:0019438 18 15 0,000 0,02091869 0,03607562 ! cilium assembly GO:0042384 22 15 0,000 0,02091869 0,03604943 ! regulation of calcium-mediated signaling GO:0050848 28 15 0,000 0,02091869 0,03602327 ! inner ear receptor cell differentiation GO:0060113 30 15 0,000 0,02091869 0,03599714 ! peptide hormone processing GO:0016486 23 15 0,000 0,02091869 0,03597106 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 36 15 0,000 0,02091869 0,03594501 ! sulfur amino acid biosynthetic process GO:0000097 21 16 0,000 0,02229817 0,03828766 ! bone remodeling GO:0046849 24 16 0,000 0,02229817 0,03825998 ! negative regulation of nucleocytoplasmic transport GO:0046823 29 16 0,000 0,02229817 0,03823233 ! positive regulation of nucleocytoplasmic transport GO:0046824 28 16 0,000 0,02229817 0,03820473 ! regulation of cell-cell adhesion GO:0022407 38 16 0,000 0,02229817 0,03817716 ! bile acid metabolic process GO:0008206 23 16 0,000 0,02229817 0,03814964 ! axis specification GO:0009798 26 16 0,000 0,02229817 0,03812215 ! negative regulation of endothelial cell proliferation GO:0001937 33 16 0,000 0,02229817 0,03809471 ! mitotic chromosome condensation GO:0007076 26 16 0,000 0,02229817 0,0380673 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,02229817 0,03803994 ! centrosome cycle GO:0007098 18 16 0,000 0,02229817 0,03801261 ! cell differentiation in spinal cord GO:0021515 24 16 0,000 0,02229817 0,03798532 ! regulation of survival gene product expression GO:0045884 23 16 0,000 0,02229817 0,03795807 ! pyrimidine ribonucleotide metabolic process GO:0009218 20 16 0,000 0,02229817 0,03793086 ! cellular response to starvation GO:0009267 26 16 0,000 0,02229817 0,03790369 ! DNA integration GO:0015074 25 16 0,000 0,02229817 0,03787656 ! branching involved in ureteric bud morphogenesis GO:0001658 24 16 0,000 0,02229817 0,03784946 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 35 16 0,000 0,02229817 0,03782241 ! regulation of exocytosis GO:0017157 28 16 0,000 0,02229817 0,03779539 ! embryonic digit morphogenesis GO:0042733 20 16 0,000 0,02229817 0,03776842 ! positive regulation of biomineral formation GO:0070169 23 16 0,000 0,02229817 0,03774148 ! regulation of vasodilation GO:0042312 26 16 0,000 0,02229817 0,03771458 ! DNA replication initiation GO:0006270 26 16 0,000 0,02229817 0,03768771 ! DNA unwinding during replication GO:0006268 24 16 0,000 0,02229817 0,03766089 ! regulation of steroid metabolic process GO:0019218 23 16 0,000 0,02229817 0,0376341 ! neuron recognition GO:0008038 27 16 0,000 0,02229817 0,03760736 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 22 16 0,000 0,02229817 0,03758065 ! G1 phase GO:0051318 28 16 0,000 0,02229817 0,03755397 ! cellular amino acid derivative catabolic process GO:0042219 31 16 0,000 0,02229817 0,03752734 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,02229817 0,03750074 GO:0006626|protein targeting to mitochondrion, ! positive regulation of oxidoreductase activity GO:0051353 22 16 0,000 0,02229817 0,03747419 ! negative regulation of blood coagulation GO:0030195 21 16 0,000 0,02229817 0,03744766 ! negative regulation of tissue remodeling GO:0034104 35 16 0,000 0,02229817 0,03742118 ! NADP metabolic process GO:0006739 22 16 0,000 0,02229817 0,03739474 ! neuromuscular synaptic transmission GO:0007274 31 16 0,000 0,02229817 0,03736833 ! synaptic transmission, cholinergic GO:0007271 24 16 0,000 0,02229817 0,03734196 ! folic acid and derivative metabolic process GO:0006760 18 16 0,000 0,02229817 0,03731562 ! regulation of T-helper cell differentiation GO:0045622 25 16 0,000 0,02229817 0,03728932 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,02229817 0,03726306 ! aspartate family amino acid biosynthetic process GO:0009067 19 16 0,000 0,02229817 0,03723684 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 24 16 0,000 0,02229817 0,03721065 ! positive regulation of neuron apoptosis GO:0043525 30 16 0,000 0,02229817 0,0371845 ! regulation of blood vessel endothelial cell migration GO:0043535 37 16 0,000 0,02229817 0,03715839 ! RNA 3'-end processing GO:0031123 23 16 0,000 0,02229817 0,03713232 ! defense response to virus GO:0051607 28 16 0,000 0,02229817 0,03710628 ! peptide hormone secretion GO:0030072 26 16 0,000 0,02229817 0,03708027 ! positive regulation of protein complex assembly GO:0031334 26 17 0,000 0,02367577 0,03934355 ! regulation of lipid biosynthetic process GO:0046890 22 17 0,000 0,02367577 0,03931602 ! negative regulation of cell cycle process GO:0010948 37 17 0,000 0,02367577 0,03928853 ! zinc ion transport GO:0006829 22 17 0,000 0,02367577 0,03926107 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,02367577 0,03923365 ! protein amino acid deacetylation GO:0006476 23 17 0,000 0,02367577 0,03920628 ! heterophilic cell adhesion GO:0007157 38 17 0,000 0,02367577 0,03917894 ! protein amino acid acetylation GO:0006473 33 17 0,000 0,02367577 0,03915163 ! regulation of neurotransmitter secretion GO:0046928 32 17 0,000 0,02367577 0,03912437 ! forelimb morphogenesis GO:0035136 20 17 0,000 0,02367577 0,03909714 ! negative regulation of ion transport GO:0043271 19 17 0,000 0,02367577 0,03906995 ! regulation of muscle cell differentiation GO:0051147 26 17 0,000 0,02367577 0,0390428 ! adult walking behavior GO:0007628 30 17 0,000 0,02367577 0,03901569 ! patterning of blood vessels GO:0001569 27 17 0,000 0,02367577 0,03898861 ! mechanoreceptor differentiation GO:0042490 32 17 0,000 0,02367577 0,03896158 ! cellular response to hydrogen peroxide GO:0070301 25 17 0,000 0,02367577 0,03893458 GO:0042744|hydrogen peroxide catabolic process, ! retinoid metabolic process GO:0001523 22 17 0,000 0,02367577 0,03890761 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 26 17 0,000 0,02367577 0,03888069 ! positive regulation of proteolysis GO:0045862 21 17 0,000 0,02367577 0,0388538 ! cardiac muscle tissue development GO:0048738 27 17 0,000 0,02367577 0,03882695 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,02367577 0,03880013 ! protein polyubiquitination GO:0000209 31 17 0,000 0,02367577 0,03877336 ! cerebral cortex development GO:0021987 34 17 0,000 0,02367577 0,03874662 ! complement activation, alternative pathway GO:0006957 17 17 0,000 0,02367577 0,03871991 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,02367577 0,03869325 ! fructose metabolic process GO:0006000 24 17 0,000 0,02367577 0,03866662 ! neuromuscular junction development GO:0007528 25 17 0,000 0,02367577 0,03864002 ! L-amino acid transport GO:0015807 27 17 0,000 0,02367577 0,03861347 ! regulation of protein binding GO:0043393 29 17 0,000 0,02367577 0,03858695 ! peptide secretion GO:0002790 30 17 0,000 0,02367577 0,03856046 ! stem cell differentiation GO:0048863 40 17 0,000 0,02367577 0,03853401 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,02367577 0,0385076 ! intermediate filament-based process GO:0045103 29 17 0,000 0,02367577 0,03848123 ! protein export from nucleus GO:0006611 26 17 0,000 0,02367577 0,03845489 ! nucleotide-excision repair, DNA gap filling GO:0006297 23 17 0,000 0,02367577 0,03842859 ! diencephalon development GO:0021536 27 17 0,000 0,02367577 0,03840232 ! oogenesis GO:0048477 25 17 0,000 0,02367577 0,03837609 ! long-chain fatty acid transport GO:0015909 25 17 0,000 0,02367577 0,03834989 ! peptide biosynthetic process GO:0043043 22 17 0,000 0,02367577 0,03832373 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,02367577 0,03829761 GO:0046467|membrane lipid biosynthetic process, ! biomineral formation GO:0031214 21 17 0,000 0,02367577 0,03827152 ! vitamin A metabolic process GO:0006776 23 17 0,000 0,02367577 0,03824547 ! steroid catabolic process GO:0006706 24 17 0,000 0,02367577 0,03821945 ! porphyrin biosynthetic process GO:0006779 24 17 0,000 0,02367577 0,03819347 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 23 17 0,000 0,02367577 0,03816752 ! nerve development GO:0021675 20 17 0,000 0,02367577 0,03814161 ! negative regulation of homeostatic process GO:0032845 29 17 0,000 0,02367577 0,03811573 ! regulation of mitotic metaphase/anaphase transition GO:0030071 33 17 0,000 0,02367577 0,03808989 ! protein secretion GO:0009306 32 18 0,000 0,02505149 0,04027588 ! regulation of glucose metabolic process GO:0010906 25 18 0,000 0,02505149 0,04024861 ! positive regulation of cell killing GO:0031343 27 18 0,000 0,02505149 0,04022138 ! negative regulation of defense response GO:0031348 21 18 0,000 0,02505149 0,04019418 ! pteridine and derivative metabolic process GO:0042558 23 18 0,000 0,02505149 0,04016702 ! positive regulation of anti-apoptosis GO:0045768 33 18 0,000 0,02505149 0,0401399 ! metencephalon development GO:0022037 25 18 0,000 0,02505149 0,04011282 ! positive regulation of hormone secretion GO:0046887 28 18 0,000 0,02505149 0,04008577 ! hormone secretion GO:0046879 28 18 0,000 0,02505149 0,04005876 ! 2'-deoxyribonucleotide metabolic process GO:0009394 24 18 0,000 0,02505149 0,04003178 GO:0019692|deoxyribose phosphate metabolic process, ! signal complex assembly GO:0007172 32 18 0,000 0,02505149 0,04000484 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 27 18 0,000 0,02505149 0,03997794 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,02505149 0,03995107 ! intra-Golgi vesicle-mediated transport GO:0006891 28 18 0,000 0,02505149 0,03992424 ! protein amino acid ADP-ribosylation GO:0006471 30 18 0,000 0,02505149 0,03989745 ! cAMP metabolic process GO:0046058 33 18 0,000 0,02505149 0,03987069 ! regulation of postsynaptic membrane potential GO:0060078 31 18 0,000 0,02505149 0,03984396 ! glial cell development GO:0021782 31 18 0,000 0,02505149 0,03981728 ! regulation of systemic arterial blood pressure by hormone GO:0001990 27 18 0,000 0,02505149 0,03979063 GO:0050886|endocrine process, ! myoblast differentiation GO:0045445 31 18 0,000 0,02505149 0,03976401 ! inactivation of MAPK activity GO:0000188 28 18 0,000 0,02505149 0,03973743 ! negative regulation of epithelial cell proliferation GO:0050680 36 18 0,000 0,02505149 0,03971088 ! vacuolar transport GO:0007034 26 18 0,000 0,02505149 0,03968438 ! pigmentation during development GO:0048066 35 18 0,000 0,02505149 0,0396579 ! cell-substrate junction assembly GO:0007044 45 18 0,000 0,02505149 0,03963146 ! cellular macromolecular complex disassembly GO:0034623 30 18 0,000 0,02505149 0,03960506 ! cellular response to unfolded protein GO:0034620 24 18 0,000 0,02505149 0,03957869 GO:0030968|endoplasmic reticulum unfolded protein response, ! fucose metabolic process GO:0006004 27 18 0,000 0,02505149 0,03955236 ! actin filament bundle formation GO:0051017 30 18 0,000 0,02505149 0,03952606 ! body fluid secretion GO:0007589 27 18 0,000 0,02505149 0,0394998 ! NLS-bearing substrate import into nucleus GO:0006607 40 18 0,000 0,02505149 0,03947357 ! behavioral interaction between organisms GO:0051705 26 18 0,000 0,02505149 0,03944738 ! negative regulation of immune response GO:0050777 33 18 0,000 0,02505149 0,03942122 ! heart process GO:0003015 32 18 0,000 0,02505149 0,03939509 GO:0060047|heart contraction, ! regulation of T cell mediated immunity GO:0002709 39 18 0,000 0,02505149 0,039369 ! sensory perception of pain GO:0019233 26 18 0,000 0,02505149 0,03934295 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 18 0,000 0,02505149 0,03931693 ! ribosomal small subunit biogenesis GO:0042274 22 18 0,000 0,02505149 0,03929094 ! somitogenesis GO:0001756 25 18 0,000 0,02505149 0,03926499 ! neural crest cell migration GO:0001755 28 18 0,000 0,02505149 0,03923907 ! neutrophil chemotaxis GO:0030593 26 18 0,000 0,02505149 0,03921319 ! positive regulation of intracellular transport GO:0032388 30 18 0,000 0,02505149 0,03918734 ! negative regulation of intracellular transport GO:0032387 31 18 0,000 0,02505149 0,03916152 ! synaptogenesis GO:0007416 28 18 0,000 0,02505149 0,03913574 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,02505149 0,03911 ! purine nucleotide catabolic process GO:0006195 27 18 0,000 0,02505149 0,03908428 ! proximal/distal pattern formation GO:0009954 28 18 0,000 0,02505149 0,0390586 ! regulation of generation of precursor metabolites and energy GO:0043467 29 18 0,000 0,02505149 0,03903296 ! aromatic compound catabolic process GO:0019439 26 18 0,000 0,02505149 0,03900735 ! somatic recombination of immunoglobulin gene segments GO:0016447 28 18 0,000 0,02505149 0,03898177 ! gut development GO:0048565 29 18 0,000 0,02505149 0,03895622 ! antigen receptor-mediated signaling pathway GO:0050851 33 18 0,000 0,02505149 0,03893071 ! positive regulation of synaptic transmission GO:0050806 26 18 0,000 0,02505149 0,03890523 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 28 19 0,000 0,02642535 0,04101201 ! positive regulation of translation GO:0045727 29 19 0,000 0,02642535 0,0409852 ! phosphatidylinositol metabolic process GO:0046488 24 19 0,000 0,02642535 0,04095843 ! glycerol metabolic process GO:0006071 22 19 0,000 0,02642535 0,0409317 ! phosphoinositide phosphorylation GO:0046854 26 19 0,000 0,02642535 0,040905 ! endothelial cell migration GO:0043542 24 19 0,000 0,02642535 0,04087833 ! glycosaminoglycan biosynthetic process GO:0006024 27 19 0,000 0,02642535 0,0408517 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 23 19 0,000 0,02642535 0,0408251 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 19 0,000 0,02642535 0,04079854 ! memory GO:0007613 28 19 0,000 0,02642535 0,04077202 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 19 0,000 0,02642535 0,04074552 ! pancreas development GO:0031016 27 19 0,000 0,02642535 0,04071906 ! response to carbohydrate stimulus GO:0009743 28 19 0,000 0,02642535 0,04069264 ! DNA duplex unwinding GO:0032508 28 19 0,000 0,02642535 0,04066625 GO:0032392|DNA geometric change, ! peroxisome organization GO:0007031 30 19 0,000 0,02642535 0,0406399 ! central nervous system neuron development GO:0021954 33 19 0,000 0,02642535 0,04061357 ! polysaccharide catabolic process GO:0000272 24 19 0,000 0,02642535 0,04058729 ! actin polymerization or depolymerization GO:0008154 32 19 0,000 0,02642535 0,04056103 ! vesicle docking during exocytosis GO:0006904 25 19 0,000 0,02642535 0,04053482 ! heme metabolic process GO:0042168 29 19 0,000 0,02642535 0,04050863 ! negative regulation of protein catabolic process GO:0042177 29 19 0,000 0,02642535 0,04048248 ! response to fungus GO:0009620 21 19 0,000 0,02642535 0,04045636 ! ventricular cardiac muscle morphogenesis GO:0055010 25 19 0,000 0,02642535 0,04043028 ! determination of left/right symmetry GO:0007368 24 19 0,000 0,02642535 0,04040423 ! prostaglandin metabolic process GO:0006693 34 19 0,000 0,02642535 0,04037821 GO:0006692|prostanoid metabolic process, ! regulation of immunoglobulin mediated immune response GO:0002889 29 19 0,000 0,02642535 0,04035223 GO:0002712|regulation of B cell mediated immunity, ! detection of chemical stimulus GO:0009593 28 19 0,000 0,02642535 0,04032628 ! vitamin transport GO:0051180 26 19 0,000 0,02642535 0,04030036 ! sarcomere organization GO:0045214 26 19 0,000 0,02642535 0,04027448 ! positive regulation of myeloid cell differentiation GO:0045639 50 19 0,000 0,02642535 0,04024863 ! regulation of immunoglobulin production GO:0002637 29 19 0,000 0,02642535 0,04022281 ! positive regulation of transmission of nerve impulse GO:0051971 27 19 0,000 0,02642535 0,04019703 ! leukotriene biosynthetic process GO:0019370 27 19 0,000 0,02642535 0,04017127 GO:0043450|alkene biosynthetic process, ! regulation of glucose import GO:0046324 23 19 0,000 0,02642535 0,04014556 GO:0010827|regulation of glucose transport, ! negative regulation of coagulation GO:0050819 25 19 0,000 0,02642535 0,04011987 ! oligosaccharide metabolic process GO:0009311 35 20 0,000 0,02779734 0,04217589 ! positive regulation of angiogenesis GO:0045766 42 20 0,000 0,02779734 0,04214894 ! determination of bilateral symmetry GO:0009855 26 20 0,000 0,02779734 0,04212203 GO:0009799|determination of symmetry, ! N-acetylglucosamine metabolic process GO:0006044 25 20 0,000 0,02779734 0,04209515 ! lipid phosphorylation GO:0046834 28 20 0,000 0,02779734 0,0420683 ! aminoglycan biosynthetic process GO:0006023 28 20 0,000 0,02779734 0,04204149 ! hindlimb morphogenesis GO:0035137 35 20 0,000 0,02779734 0,04201471 ! C21-steroid hormone metabolic process GO:0008207 25 20 0,000 0,02779734 0,04198797 ! calcium-independent cell-cell adhesion GO:0016338 23 20 0,000 0,02779734 0,04196126 ! response to alkaloid GO:0043279 34 20 0,000 0,02779734 0,04193458 ! sensory perception of taste GO:0050909 26 20 0,000 0,02779734 0,04190794 ! response to retinoic acid GO:0032526 27 20 0,000 0,02779734 0,04188133 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 20 0,000 0,02779734 0,04185476 ! cellular response to reactive oxygen species GO:0034614 32 20 0,000 0,02779734 0,04182821 ! D-ribose metabolic process GO:0006014 27 20 0,000 0,02779734 0,04180171 ! chromosome condensation GO:0030261 32 20 0,000 0,02779734 0,04177523 ! peptidyl-serine phosphorylation GO:0018105 31 20 0,000 0,02779734 0,04174879 ! sex determination GO:0007530 32 20 0,000 0,02779734 0,04172239 ! plasma membrane fusion GO:0045026 24 20 0,000 0,02779734 0,04169601 ! fatty acid beta-oxidation GO:0006635 32 20 0,000 0,02779734 0,04166967 ! positive regulation of alpha-beta T cell differentiation GO:0046638 29 20 0,000 0,02779734 0,04164337 ! cytolysis GO:0019835 21 20 0,000 0,02779734 0,04161709 ! renal system process GO:0003014 35 20 0,000 0,02779734 0,04159085 ! vasodilation GO:0042311 36 20 0,000 0,02779734 0,04156465 ! negative regulation of angiogenesis GO:0016525 38 20 0,000 0,02779734 0,04153847 ! detection of biotic stimulus GO:0009595 23 20 0,000 0,02779734 0,04151233 ! cellular response to nutrient levels GO:0031669 32 20 0,000 0,02779734 0,04148622 ! positive regulation of neurological system process GO:0031646 31 20 0,000 0,02779734 0,04146015 ! hormone transport GO:0009914 30 20 0,000 0,02779734 0,0414341 ! negative regulation of neuron differentiation GO:0045665 33 20 0,000 0,02779734 0,04140809 ! activation of JUN kinase activity GO:0007257 28 20 0,000 0,02779734 0,04138212 ! regulation of leukocyte mediated cytotoxicity GO:0001910 34 20 0,000 0,02779734 0,04135617 ! estrogen receptor signaling pathway GO:0030520 36 20 0,000 0,02779734 0,04133026 ! sperm-egg recognition GO:0035036 24 20 0,000 0,02779734 0,04130438 GO:0007339|binding of sperm to zona pellucida, ! embryonic organ morphogenesis GO:0048562 26 20 0,000 0,02779734 0,04127853 ! cellular monovalent inorganic cation homeostasis GO:0030004 31 20 0,000 0,02779734 0,04125272 ! positive regulation of DNA replication GO:0045740 37 21 0,000 0,02916747 0,043259 ! positive regulation of protein catabolic process GO:0045732 25 21 0,000 0,02916747 0,04323198 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,02916747 0,043205 ! positive regulation of ossification GO:0045778 34 21 0,000 0,02916747 0,04317804 ! iron ion transport GO:0006826 49 21 0,000 0,02916747 0,04315112 ! glucosamine metabolic process GO:0006041 26 21 0,000 0,02916747 0,04312424 ! microtubule-based transport GO:0010970 41 21 0,000 0,02916747 0,04309739 ! vesicle docking GO:0048278 28 21 0,000 0,02916747 0,04307057 ! regulation of carbohydrate metabolic process GO:0006109 31 21 0,000 0,02916747 0,04304378 GO:0010675|regulation of cellular carbohydrate metabolic process, ! ovarian follicle development GO:0001541 33 21 0,000 0,02916747 0,04301703 ! response to ethanol GO:0045471 38 21 0,000 0,02916747 0,04299031 ! positive regulation of epithelial cell proliferation GO:0050679 43 21 0,000 0,02916747 0,04296363 ! smooth muscle contraction GO:0006939 39 21 0,000 0,02916747 0,04293698 ! glutamine metabolic process GO:0006541 29 21 0,000 0,02916747 0,04291036 ! response to vitamin A GO:0033189 28 21 0,000 0,02916747 0,04288377 ! purine ribonucleoside metabolic process GO:0046128 30 21 0,000 0,02916747 0,04285722 GO:0042278|purine nucleoside metabolic process, ! neurotransmitter metabolic process GO:0042133 36 21 0,000 0,02916747 0,0428307 ! response to starvation GO:0042594 35 21 0,000 0,02916747 0,04280421 ! regulation of myeloid leukocyte differentiation GO:0002761 41 21 0,000 0,02916747 0,04277775 ! leukotriene metabolic process GO:0006691 29 21 0,000 0,02916747 0,04275133 ! regulation of vasoconstriction GO:0019229 33 21 0,000 0,02916747 0,04272494 ! glycosphingolipid metabolic process GO:0006687 35 21 0,000 0,02916747 0,04269858 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 28 21 0,000 0,02916747 0,04267226 ! regulation of fatty acid metabolic process GO:0019217 32 21 0,000 0,02916747 0,04264597 ! negative regulation of Wnt receptor signaling pathway GO:0030178 32 21 0,000 0,02916747 0,04261971 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 38 21 0,000 0,02916747 0,04259348 ! positive regulation of inflammatory response GO:0050729 38 21 0,000 0,02916747 0,04256728 ! neuromuscular process controlling balance GO:0050885 54 21 0,000 0,02916747 0,04254112 ! negative regulation of myeloid cell differentiation GO:0045638 29 21 0,000 0,02916747 0,04251499 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,02916747 0,04248889 ! aromatic amino acid family metabolic process GO:0009072 30 21 0,000 0,02916747 0,04246282 ! somatic diversification of immunoglobulins GO:0016445 31 21 0,000 0,02916747 0,04243679 ! pyrimidine nucleotide biosynthetic process GO:0006221 26 21 0,000 0,02916747 0,04241079 ! regulation of microtubule polymerization or depolymerization GO:0031110 51 21 0,000 0,02916747 0,04238482 ! embryonic pattern specification GO:0009880 34 22 0,000 0,03053573 0,04434596 ! regulation of cell killing GO:0031341 37 22 0,000 0,03053573 0,04431884 ! regulation of anti-apoptosis GO:0045767 40 22 0,000 0,03053573 0,04429175 ! gluconeogenesis GO:0006094 26 22 0,000 0,03053573 0,04426469 ! viral genome replication GO:0019079 31 22 0,000 0,03053573 0,04423767 ! nucleotide-excision repair, DNA damage removal GO:0000718 27 22 0,000 0,03053573 0,04421067 ! protein amino acid O-linked glycosylation GO:0006493 36 22 0,000 0,03053573 0,04418372 ! protein amino acid acylation GO:0043543 42 22 0,000 0,03053573 0,04415679 ! response to vitamin GO:0033273 31 22 0,000 0,03053573 0,0441299 ! molting cycle process GO:0022404 43 22 0,000 0,03053573 0,04410304 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of neurotransmitter transport GO:0051588 41 22 0,000 0,03053573 0,04407621 ! regeneration GO:0031099 37 22 0,000 0,03053573 0,04404942 ! phototransduction GO:0007602 29 22 0,000 0,03053573 0,04402266 ! regulation of DNA recombination GO:0000018 43 22 0,000 0,03053573 0,04399593 ! regulation of smooth muscle contraction GO:0006940 38 22 0,000 0,03053573 0,04396923 ! deoxyribonucleotide metabolic process GO:0009262 29 22 0,000 0,03053573 0,04394257 ! central nervous system neuron differentiation GO:0021953 39 22 0,000 0,03053573 0,04391594 ! cholesterol biosynthetic process GO:0006695 32 22 0,000 0,03053573 0,04388934 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 22 0,000 0,03053573 0,04386277 ! regulation of interleukin-6 production GO:0032675 25 22 0,000 0,03053573 0,04383623 ! regulation of interleukin-2 production GO:0032663 38 22 0,000 0,03053573 0,04380973 ! pallium development GO:0021543 43 22 0,000 0,03053573 0,04378326 ! positive regulation of locomotion GO:0040017 40 22 0,000 0,03053573 0,04375682 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! fatty acid transport GO:0015908 33 22 0,000 0,03053573 0,04373041 ! platelet activation GO:0030168 33 22 0,000 0,03053573 0,04370404 ! proteoglycan biosynthetic process GO:0030166 33 22 0,000 0,03053573 0,0436777 ! regulation of cytokine secretion GO:0050707 30 22 0,000 0,03053573 0,04365138 ! positive regulation of osteoblast differentiation GO:0045669 37 22 0,000 0,03053573 0,0436251 ! cellular alkene metabolic process GO:0043449 30 22 0,000 0,03053573 0,04359885 ! cell-cell recognition GO:0009988 28 22 0,000 0,03053573 0,04357264 ! pyrimidine nucleoside metabolic process GO:0006213 28 22 0,000 0,03053573 0,04354645 ! water-soluble vitamin biosynthetic process GO:0042364 28 22 0,000 0,03053573 0,0435203 ! neural tube closure GO:0001843 35 22 0,000 0,03053573 0,04349418 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 26 22 0,000 0,03053573 0,04346808 ! regulation of multi-organism process GO:0043900 35 22 0,000 0,03053573 0,04344202 ! protein tetramerization GO:0051262 43 22 0,000 0,03053573 0,043416 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 36 23 0,000 0,03190214 0,0453316 GO:0016444|somatic cell DNA recombination, ! sulfur amino acid metabolic process GO:0000096 31 23 0,000 0,03190214 0,04530447 ! reciprocal meiotic recombination GO:0007131 41 23 0,000 0,03190214 0,04527738 ! cellular aldehyde metabolic process GO:0006081 32 23 0,000 0,03190214 0,04525031 ! positive regulation of bone remodeling GO:0046852 37 23 0,000 0,03190214 0,04522328 ! cellular polysaccharide biosynthetic process GO:0033692 29 23 0,000 0,03190214 0,04519628 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 31 23 0,000 0,03190214 0,04516932 ! dicarboxylic acid metabolic process GO:0043648 36 23 0,000 0,03190214 0,04514238 ! regulation of chemotaxis GO:0050920 41 23 0,000 0,03190214 0,04511548 ! regulation of receptor-mediated endocytosis GO:0048259 26 23 0,000 0,03190214 0,04508861 ! tube lumen formation GO:0035148 37 23 0,000 0,03190214 0,04506177 ! macromolecular complex disassembly GO:0032984 39 23 0,000 0,03190214 0,04503496 ! dendrite development GO:0016358 41 23 0,000 0,03190214 0,04500819 ! vasculogenesis GO:0001570 38 23 0,000 0,03190214 0,04498145 ! microtubule organizing center organization GO:0031023 30 23 0,000 0,03190214 0,04495474 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 50 23 0,000 0,03190214 0,04492806 ! lysosome organization GO:0007040 41 23 0,000 0,03190214 0,04490141 ! digestive system process GO:0022600 35 23 0,000 0,03190214 0,04487479 ! positive regulation of cytoskeleton organization GO:0051495 43 23 0,000 0,03190214 0,04484821 ! vesicle targeting GO:0006903 35 23 0,000 0,03190214 0,04482165 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 36 23 0,000 0,03190214 0,04479513 ! regulation of endothelial cell migration GO:0010594 44 23 0,000 0,03190214 0,04476864 ! regulation of viral reproduction GO:0050792 33 23 0,000 0,03190214 0,04474218 ! regulation of insulin secretion GO:0050796 30 23 0,000 0,03190214 0,04471576 ! regulation of alpha-beta T cell differentiation GO:0046637 35 23 0,000 0,03190214 0,04468936 ! cardiac muscle tissue morphogenesis GO:0055008 29 23 0,000 0,03190214 0,04466299 GO:0060415|muscle tissue morphogenesis, ! interaction with host GO:0051701 42 23 0,000 0,03190214 0,04463666 ! membrane depolarization GO:0051899 40 23 0,000 0,03190214 0,04461036 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,03190214 0,04458408 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 39 23 0,000 0,03190214 0,04455784 ! regulation of ARF GTPase activity GO:0032312 35 23 0,000 0,03190214 0,04453163 ! DNA modification GO:0006304 33 23 0,000 0,03190214 0,04450545 ! collagen fibril organization GO:0030199 50 23 0,000 0,03190214 0,0444793 ! synaptic vesicle transport GO:0048489 45 23 0,000 0,03190214 0,04445319 ! peptidyl-serine modification GO:0018209 37 23 0,000 0,03190214 0,0444271 ! nerve-nerve synaptic transmission GO:0007270 42 23 0,000 0,03190214 0,04440104 ! fat-soluble vitamin metabolic process GO:0006775 29 23 0,000 0,03190214 0,04437501 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,03190214 0,04434902 ! collagen catabolic process GO:0030574 29 23 0,000 0,03190214 0,04432305 ! glutamine family amino acid catabolic process GO:0009065 34 23 0,000 0,03190214 0,04429712 ! aspartate family amino acid metabolic process GO:0009066 27 23 0,000 0,03190214 0,04427121 ! porphyrin metabolic process GO:0006778 37 23 0,000 0,03190214 0,04424534 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 39 23 0,000 0,03190214 0,04421949 ! blastocyst development GO:0001824 41 23 0,000 0,03190214 0,04419368 ! actin filament-based movement GO:0030048 37 23 0,000 0,03190214 0,0441679 ! protein stabilization GO:0050821 34 23 0,000 0,03190214 0,04414214 ! protein import into nucleus, docking GO:0000059 45 24 0,000 0,03326669 0,04600341 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 30 24 0,000 0,03326669 0,04597661 ! myelination GO:0042552 39 24 0,000 0,03326669 0,04594985 ! initiation of viral infection GO:0019059 47 24 0,000 0,03326669 0,04592312 ! regulation of transmembrane transport GO:0034762 31 24 0,000 0,03326669 0,04589642 ! leukocyte adhesion GO:0007159 49 24 0,000 0,03326669 0,04586975 ! glutamate signaling pathway GO:0007215 37 24 0,000 0,03326669 0,04584312 ! regulation of transcription factor import into nucleus GO:0042990 49 24 0,000 0,03326669 0,04581651 ! spinal cord development GO:0021510 41 24 0,000 0,03326669 0,04578993 ! immune response-activating cell surface receptor signaling pathway GO:0002429 39 24 0,000 0,03326669 0,04576339 ! multicellular organismal response to stress GO:0033555 42 24 0,000 0,03326669 0,04573688 ! regulation of nitric oxide biosynthetic process GO:0045428 42 24 0,000 0,03326669 0,04571039 ! negative regulation of DNA replication GO:0008156 39 24 0,000 0,03326669 0,04568394 ! osteoblast differentiation GO:0001649 43 24 0,000 0,03326669 0,04565752 ! response to endoplasmic reticulum stress GO:0034976 32 24 0,000 0,03326669 0,04563113 ! response to toxin GO:0009636 38 24 0,000 0,03326669 0,04560476 ! primary neural tube formation GO:0014020 37 24 0,000 0,03326669 0,04557843 ! vitamin biosynthetic process GO:0009110 30 24 0,000 0,03326669 0,04555213 ! positive regulation of alpha-beta T cell activation GO:0046635 40 24 0,000 0,03326669 0,04552586 ! cellular response to oxidative stress GO:0034599 38 24 0,000 0,03326669 0,04549962 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 24 0,000 0,03326669 0,04547341 ! fibroblast growth factor receptor signaling pathway GO:0008543 45 24 0,000 0,03326669 0,04544723 ! pentose metabolic process GO:0019321 33 24 0,000 0,03326669 0,04542109 ! immunoglobulin production GO:0002377 37 24 0,000 0,03326669 0,04539497 GO:0002440|production of molecular mediator of immune response, ! regulation of response to biotic stimulus GO:0002831 45 24 0,000 0,03326669 0,04536888 ! positive regulation of protein secretion GO:0050714 29 24 0,000 0,03326669 0,04534282 ! positive regulation of adaptive immune response GO:0002821 44 24 0,000 0,03326669 0,04531679 ! regulation of blood coagulation GO:0030193 37 24 0,000 0,03326669 0,04529079 ! positive regulation of tissue remodeling GO:0034105 41 24 0,000 0,03326669 0,04526482 ! group transfer coenzyme metabolic process GO:0006752 29 24 0,000 0,03326669 0,04523888 ! positive regulation of JUN kinase activity GO:0043507 33 24 0,000 0,03326669 0,04521297 ! neuron fate commitment GO:0048663 38 25 0,000 0,03462938 0,04703807 ! pyruvate metabolic process GO:0006090 32 25 0,000 0,03462938 0,04701117 ! superoxide metabolic process GO:0006801 33 25 0,000 0,03462938 0,04698429 ! detection of light stimulus involved in sensory perception GO:0050962 32 25 0,000 0,03462938 0,04695744 GO:0050908|detection of light stimulus involved in visual perception, ! activation of pro-apoptotic gene products GO:0008633 44 25 0,000 0,03462938 0,04693062 ! mitochondrial membrane organization GO:0007006 42 25 0,000 0,03462938 0,04690383 ! vacuole organization GO:0007033 43 25 0,000 0,03462938 0,04687708 ! receptor metabolic process GO:0043112 40 25 0,000 0,03462938 0,04685035 ! barbed-end actin filament capping GO:0051016 41 25 0,000 0,03462938 0,04682366 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 35 25 0,000 0,03462938 0,04679699 ! regulation of behavior GO:0050795 45 25 0,000 0,03462938 0,04677036 ! hydrogen peroxide metabolic process GO:0042743 35 25 0,000 0,03462938 0,04674375 ! immune response-regulating cell surface receptor signaling pathway GO:0002768 45 25 0,000 0,03462938 0,04671718 ! lymphocyte proliferation GO:0046651 42 25 0,000 0,03462938 0,04669063 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,03462938 0,04666412 ! regulation of tumor necrosis factor production GO:0032680 32 25 0,000 0,03462938 0,04663764 ! somatic diversification of immune receptors GO:0002200 38 25 0,000 0,03462938 0,04661118 ! camera-type eye morphogenesis GO:0048593 43 25 0,000 0,03462938 0,04658476 ! negative regulation of catabolic process GO:0009895 37 25 0,000 0,03462938 0,04655837 ! regulation of amine transport GO:0051952 44 25 0,000 0,03462938 0,046532 ! liver development GO:0001889 44 25 0,000 0,03462938 0,04650567 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 38 26 0,000 0,03599022 0,04830588 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 31 26 0,000 0,03599022 0,04827857 ! positive regulation of cell projection organization GO:0031346 43 26 0,000 0,03599022 0,04825129 ! regulation of cellular catabolic process GO:0031329 39 26 0,000 0,03599022 0,04822405 ! regulation of interferon-gamma production GO:0032649 33 26 0,000 0,03599022 0,04819684 ! cellular iron ion homeostasis GO:0006879 47 26 0,000 0,03599022 0,04816965 ! amino sugar metabolic process GO:0006040 32 26 0,000 0,03599022 0,0481425 ! protein amino acid alkylation GO:0008213 40 26 0,000 0,03599022 0,04811538 GO:0006479|protein amino acid methylation, ! odontogenesis of dentine-containing tooth GO:0042475 43 26 0,000 0,03599022 0,04808828 ! sperm motility GO:0030317 31 26 0,000 0,03599022 0,04806122 ! ER-nuclear signaling pathway GO:0006984 33 26 0,000 0,03599022 0,04803419 ! peptidyl-tyrosine phosphorylation GO:0018108 42 26 0,000 0,03599022 0,04800719 ! male gonad development GO:0008584 39 26 0,000 0,03599022 0,04798022 ! neural crest cell development GO:0014032 44 26 0,000 0,03599022 0,04795328 GO:0014033|neural crest cell differentiation, ! base-excision repair GO:0006284 35 26 0,000 0,03599022 0,04792637 ! cell fate determination GO:0001709 54 26 0,000 0,03599022 0,04789949 ! regulation of chromosome organization GO:0033044 37 26 0,000 0,03599022 0,04787264 ! regulation of oxidoreductase activity GO:0051341 42 26 0,000 0,03599022 0,04784582 ! detection of visible light GO:0009584 33 26 0,000 0,03599022 0,04781903 ! spermatid development GO:0007286 40 26 0,000 0,03599022 0,04779227 ! regulation of bone mineralization GO:0030500 38 26 0,000 0,03599022 0,04776554 ! regulation of osteoblast differentiation GO:0045667 41 26 0,000 0,03599022 0,04773884 ! acetyl-CoA catabolic process GO:0046356 38 26 0,000 0,03599022 0,04771217 GO:0006099|tricarboxylic acid cycle, ! regulation of JUN kinase activity GO:0043506 39 26 0,000 0,03599022 0,04768553 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,03734921 0,04945852 ! spliceosomal snRNP biogenesis GO:0000387 38 27 0,000 0,03734921 0,04943094 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 47 27 0,000 0,03734921 0,04940339 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 42 27 0,000 0,03734921 0,04937586 ! membrane docking GO:0022406 40 27 0,000 0,03734921 0,04934837 ! circadian rhythm GO:0007623 44 27 0,000 0,03734921 0,04932091 ! regulation of endothelial cell proliferation GO:0001936 52 27 0,000 0,03734921 0,04929348 ! fat cell differentiation GO:0045444 41 27 0,000 0,03734921 0,04926608 ! positive regulation of innate immune response GO:0045089 34 27 0,000 0,03734921 0,04923871 ! autophagy GO:0006914 36 27 0,000 0,03734921 0,04921137 ! regulation of cellular ketone metabolic process GO:0010565 38 27 0,000 0,03734921 0,04918406 ! peptide transport GO:0015833 46 27 0,000 0,03734921 0,04915678 ! coenzyme catabolic process GO:0009109 40 27 0,000 0,03734921 0,04912953 ! regulation of peptide secretion GO:0002791 39 27 0,000 0,03734921 0,04910231 ! negative regulation of cell development GO:0010721 67 27 0,000 0,03734921 0,04907513 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 46 27 0,000 0,03734921 0,04904797 ! positive regulation of leukocyte mediated immunity GO:0002705 45 27 0,000 0,03734921 0,04902084 GO:0002708|positive regulation of lymphocyte mediated immunity, ! phospholipid transport GO:0015914 40 27 0,000 0,03734921 0,04899374 ! detection of light stimulus GO:0009583 35 27 0,000 0,03734921 0,04896667 ! glutathione metabolic process GO:0006749 35 27 0,000 0,03734921 0,04893963 ! lipid oxidation GO:0034440 39 27 0,000 0,03734921 0,04891263 GO:0019395|fatty acid oxidation, ! leukocyte proliferation GO:0070661 45 27 0,000 0,03734921 0,04888565 GO:0032943|mononuclear cell proliferation, ! telomere organization GO:0032200 39 27 0,000 0,03734921 0,0488587 GO:0000723|telomere maintenance, ! protein import into nucleus, translocation GO:0000060 47 28 0,000 0,03870635 0,05060616 ! positive regulation of smooth muscle cell proliferation GO:0048661 45 28 0,000 0,03870635 0,05057829 ! translational initiation GO:0006413 48 28 0,000 0,03870635 0,05055046 ! negative regulation of actin filament depolymerization GO:0030835 44 28 0,000 0,03870635 0,05052265 ! acetyl-CoA metabolic process GO:0006084 42 28 0,000 0,03870635 0,05049488 ! regulation of pH GO:0006885 40 28 0,000 0,03870635 0,05046713 ! catechol metabolic process GO:0009712 46 28 0,000 0,03870635 0,05043942 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 43 28 0,000 0,03870635 0,05041173 ! cellular carbohydrate biosynthetic process GO:0034637 37 28 0,000 0,03870635 0,05038408 ! iron ion homeostasis GO:0055072 49 28 0,000 0,03870635 0,05035646 ! regulation of biomineral formation GO:0070167 40 28 0,000 0,03870635 0,05032886 ! peptidyl-tyrosine modification GO:0018212 44 28 0,000 0,03870635 0,0503013 ! neurotransmitter secretion GO:0007269 41 28 0,000 0,03870635 0,05027377 ! negative regulation of transcription regulator activity GO:0090048 48 28 0,000 0,03870635 0,05024627 GO:0043433|negative regulation of transcription factor activity, ! gene silencing GO:0016458 47 28 0,000 0,03870635 0,0502188 ! regulation of coagulation GO:0050818 42 28 0,000 0,03870635 0,05019135 ! negative regulation of actin filament polymerization GO:0030837 45 29 0,000 0,04006165 0,05192043 ! phenol metabolic process GO:0018958 47 29 0,000 0,04006165 0,05189209 ! icosanoid biosynthetic process GO:0046456 45 29 0,000 0,04006165 0,05186378 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 39 29 0,000 0,04006165 0,0518355 ! calcium-dependent cell-cell adhesion GO:0016339 36 29 0,000 0,04006165 0,05180725 ! negative regulation of response to external stimulus GO:0032102 39 29 0,000 0,04006165 0,05177903 ! cholesterol transport GO:0030301 48 29 0,000 0,04006165 0,05175084 GO:0015918|sterol transport, ! cholesterol homeostasis GO:0042632 53 29 0,000 0,04006165 0,05172269 GO:0055092|sterol homeostasis, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 39 29 0,000 0,04006165 0,05169456 ! GPI anchor metabolic process GO:0006505 47 29 0,000 0,04006165 0,05166647 ! complement activation, classical pathway GO:0006958 39 29 0,000 0,04006165 0,0516384 ! multicellular organismal catabolic process GO:0044243 36 29 0,000 0,04006165 0,05161037 ! respiratory gaseous exchange GO:0007585 51 29 0,000 0,04006165 0,05158237 ! triglyceride metabolic process GO:0006641 38 29 0,000 0,04006165 0,05155439 ! response to ionizing radiation GO:0010212 55 29 0,000 0,04006165 0,05152645 ! response to organic cyclic substance GO:0014070 53 29 0,000 0,04006165 0,05149854 ! regulation of systemic arterial blood pressure GO:0003073 52 29 0,000 0,04006165 0,05147066 ! mesoderm formation GO:0001707 52 29 0,000 0,04006165 0,0514428 ! response to estradiol stimulus GO:0032355 38 29 0,000 0,04006165 0,05141498 ! positive regulation of MAPKKK cascade GO:0043410 45 29 0,000 0,04006165 0,05138719 ! regulation of microtubule cytoskeleton organization GO:0070507 61 29 0,000 0,04006165 0,05135943 ! ensheathment of neurons GO:0007272 48 29 0,000 0,04006165 0,0513317 GO:0008366|axon ensheathment, ! serine family amino acid metabolic process GO:0009069 41 29 0,000 0,04006165 0,05130399 ! spermatid differentiation GO:0048515 45 29 0,000 0,04006165 0,05127632 ! myeloid leukocyte activation GO:0002274 44 29 0,000 0,04006165 0,05124868 ! neural tube formation GO:0001841 46 29 0,000 0,04006165 0,05122107 ! regulation of actin filament depolymerization GO:0030834 47 30 0,000 0,04141511 0,05292302 ! organic anion transport GO:0015711 50 30 0,000 0,04141511 0,05289454 ! cell junction assembly GO:0034329 65 30 0,000 0,04141511 0,05286608 ! acute-phase response GO:0006953 49 30 0,000 0,04141511 0,05283766 ! segmentation GO:0035282 43 30 0,000 0,04141511 0,05280927 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 56 30 0,000 0,04141511 0,05278091 ! negative regulation of protein kinase cascade GO:0010741 58 30 0,000 0,04141511 0,05275258 ! immune response-activating signal transduction GO:0002757 45 30 0,000 0,04141511 0,05272428 ! regulation of protein import into nucleus GO:0042306 56 30 0,000 0,04141511 0,05269601 ! regulation of production of molecular mediator of immune response GO:0002700 47 30 0,000 0,04141511 0,05266777 ! ceramide metabolic process GO:0006672 47 30 0,000 0,04141511 0,05263956 ! formation of primary germ layer GO:0001704 54 30 0,000 0,04141511 0,05261138 ! nicotinamide metabolic process GO:0006769 47 30 0,000 0,04141511 0,05258323 GO:0046496|nicotinamide nucleotide metabolic process, ! fatty acid catabolic process GO:0009062 45 30 0,000 0,04141511 0,05255511 ! regulation of calcium ion transport GO:0051924 40 30 0,000 0,04141511 0,05252702 ! negative regulation of protein polymerization GO:0032272 47 30 0,000 0,04141511 0,05249896 ! negative regulation of protein transport GO:0051224 53 30 0,000 0,04141511 0,05247093 ! response to heat GO:0009408 43 30 0,000 0,04141511 0,05244293 ! establishment of vesicle localization GO:0051650 48 30 0,000 0,04141511 0,05241496 ! alkaloid metabolic process GO:0009820 48 31 0,000 0,04276672 0,05409671 ! response to hydrogen peroxide GO:0042542 48 31 0,000 0,04276672 0,05406789 ! post-embryonic development GO:0009791 50 31 0,000 0,04276672 0,0540391 ! inner ear morphogenesis GO:0042472 43 31 0,000 0,04276672 0,05401034 ! regulation of innate immune response GO:0045088 42 31 0,000 0,04276672 0,05398161 ! ovulation cycle process GO:0022602 46 31 0,000 0,04276672 0,05395292 ! mesoderm morphogenesis GO:0048332 54 31 0,000 0,04276672 0,05392425 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 42 31 0,000 0,04276672 0,05389561 ! immune response-regulating signal transduction GO:0002764 51 31 0,000 0,04276672 0,053867 ! positive regulation of neurogenesis GO:0050769 49 31 0,000 0,04276672 0,05383843 ! positive regulation of T cell differentiation GO:0045582 45 31 0,000 0,04276672 0,05380988 ! positive regulation of multicellular organism growth GO:0040018 42 31 0,000 0,04276672 0,05378136 ! hexose biosynthetic process GO:0019319 37 31 0,000 0,04276672 0,05375288 ! negative regulation of MAP kinase activity GO:0043407 57 31 0,000 0,04276672 0,05372442 ! sterol biosynthetic process GO:0016126 48 31 0,000 0,04276672 0,053696 ! biogenic amine biosynthetic process GO:0042401 45 31 0,000 0,04276672 0,0536676 ! embryonic epithelial tube formation GO:0001838 50 31 0,000 0,04276672 0,05363924 ! tissue homeostasis GO:0001894 45 31 0,000 0,04276672 0,0536109 GO:0048871|multicellular organismal homeostasis, ! mitotic sister chromatid segregation GO:0000070 47 32 0,000 0,0441165 0,05527374 ! DNA damage checkpoint GO:0000077 57 32 0,000 0,0441165 0,05524457 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 49 32 0,000 0,0441165 0,05521543 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 45 32 0,000 0,0441165 0,05518632 ! negative regulation of protein complex assembly GO:0031333 51 32 0,000 0,0441165 0,05515725 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 39 32 0,000 0,0441165 0,0551282 ! positive regulation of endocytosis GO:0045807 39 32 0,000 0,0441165 0,05509919 ! positive regulation of T cell proliferation GO:0042102 56 32 0,000 0,0441165 0,0550702 ! regulation of striated muscle tissue development GO:0016202 51 32 0,000 0,0441165 0,05504125 ! unsaturated fatty acid biosynthetic process GO:0006636 50 32 0,000 0,0441165 0,05501233 ! regulation of axonogenesis GO:0050770 60 32 0,000 0,0441165 0,05498343 ! telencephalon development GO:0021537 59 32 0,000 0,0441165 0,05495457 ! ovulation cycle GO:0042698 48 32 0,000 0,0441165 0,05492574 ! cofactor catabolic process GO:0051187 52 32 0,000 0,0441165 0,05489694 ! pyridine nucleotide metabolic process GO:0019362 49 32 0,000 0,0441165 0,05486816 ! positive regulation of catabolic process GO:0009896 44 32 0,000 0,0441165 0,05483942 ! placenta development GO:0001890 45 32 0,000 0,0441165 0,05481071 ! symbiosis, encompassing mutualism through parasitism GO:0044403 52 32 0,000 0,0441165 0,05478203 ! vesicle localization GO:0051648 50 32 0,000 0,0441165 0,05475338 ! regulation of muscle development GO:0048634 52 33 0,000 0,04546444 0,05639682 ! mRNA export from nucleus GO:0006406 47 33 0,000 0,04546444 0,05636736 ! negative regulation of secretion GO:0051048 53 33 0,000 0,04546444 0,05633792 ! negative regulation of DNA metabolic process GO:0051053 53 33 0,000 0,04546444 0,05630852 ! glial cell differentiation GO:0010001 65 33 0,000 0,04546444 0,05627915 ! sister chromatid segregation GO:0000819 48 33 0,000 0,04546444 0,0562498 ! sphingoid metabolic process GO:0046519 51 33 0,000 0,04546444 0,05622049 ! maintenance of protein location in cell GO:0032507 66 33 0,000 0,04546444 0,05619121 ! spindle organization GO:0007051 39 33 0,000 0,04546444 0,05616196 ! pigment biosynthetic process GO:0046148 55 33 0,000 0,04546444 0,05613274 ! neutral lipid metabolic process GO:0006638 45 33 0,000 0,04546444 0,05610355 GO:0006639|acylglycerol metabolic process, ! erythrocyte differentiation GO:0030218 50 33 0,000 0,04546444 0,05607439 ! nucleotide catabolic process GO:0009166 47 33 0,000 0,04546444 0,05604526 ! nuclear-transcribed mRNA catabolic process GO:0000956 47 33 0,000 0,04546444 0,05601616 ! leukocyte chemotaxis GO:0030595 48 33 0,000 0,04546444 0,05598709 GO:0060326|cell chemotaxis, ! BMP signaling pathway GO:0030509 49 33 0,000 0,04546444 0,05595805 ! calcium-mediated signaling GO:0019722 54 33 0,000 0,04546444 0,05592904 ! cytokine production GO:0001816 49 33 0,000 0,04546444 0,05590006 ! regulation of microtubule-based process GO:0032886 66 33 0,000 0,04546444 0,05587111 ! RNA modification GO:0009451 43 33 0,000 0,04546444 0,0558422 ! positive regulation of immune effector process GO:0002699 53 33 0,000 0,04546444 0,05581331 ! negative regulation of adenylate cyclase activity GO:0007194 56 34 0,000 0,04681055 0,05743611 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! ER to Golgi vesicle-mediated transport GO:0006888 57 34 0,000 0,04681055 0,05740643 ! xenobiotic metabolic process GO:0006805 49 34 0,000 0,04681055 0,05737678 ! embryonic skeletal system morphogenesis GO:0048704 49 34 0,000 0,04681055 0,05734715 ! monovalent inorganic cation homeostasis GO:0055067 49 34 0,000 0,04681055 0,05731756 ! negative regulation of DNA binding GO:0043392 54 34 0,000 0,04681055 0,057288 ! positive regulation of cell development GO:0010720 58 34 0,000 0,04681055 0,05725847 ! response to mechanical stimulus GO:0009612 46 34 0,000 0,04681055 0,05722897 ! cell fate specification GO:0001708 49 34 0,000 0,04681055 0,05719951 ! regulation of Wnt receptor signaling pathway GO:0030111 57 34 0,000 0,04681055 0,05717007 ! peripheral nervous system development GO:0007422 58 34 0,000 0,04681055 0,05714066 ! isoprenoid metabolic process GO:0006720 47 34 0,000 0,04681055 0,05711128 ! adult locomotory behavior GO:0008344 54 34 0,000 0,04681055 0,05708193 ! monosaccharide biosynthetic process GO:0046364 40 34 0,000 0,04681055 0,05705261 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 47 35 0,000 0,04815483 0,05866089 ! phosphoinositide biosynthetic process GO:0046489 54 35 0,000 0,04815483 0,05863079 ! collagen metabolic process GO:0032963 47 35 0,000 0,04815483 0,05860072 ! regulation of ARF protein signal transduction GO:0032012 56 35 0,000 0,04815483 0,05857069 ! metanephros development GO:0001656 61 35 0,000 0,04815483 0,05854068 ! positive regulation of gene-specific transcription GO:0043193 53 35 0,000 0,04815483 0,05851071 ! female gonad development GO:0008585 55 35 0,000 0,04815483 0,05848076 ! lipid homeostasis GO:0055088 63 35 0,000 0,04815483 0,05845085 ! DNA integrity checkpoint GO:0031570 61 35 0,000 0,04815483 0,05842097 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,04815483 0,05839111 ! hindbrain development GO:0030902 56 35 0,000 0,04815483 0,05836129 ! Rho protein signal transduction GO:0007266 53 35 0,000 0,04815483 0,0583315 ! positive regulation of lymphocyte differentiation GO:0045621 51 35 0,000 0,04815483 0,05830174 ! hormone biosynthetic process GO:0042446 49 35 0,000 0,04815483 0,05827201 ! embryonic organ development GO:0048568 53 35 0,000 0,04815483 0,05824231 ! pyrimidine nucleotide metabolic process GO:0006220 48 35 0,000 0,04815483 0,05821264 ! protein homooligomerization GO:0051260 59 35 0,000 0,04815483 0,058183 ! meiosis I GO:0007127 61 36 0,000 0,04949728 0,05977458 ! negative regulation of cell adhesion GO:0007162 78 36 0,000 0,04949728 0,05974417 ! regulation of metal ion transport GO:0010959 50 36 0,000 0,04949728 0,0597138 ! regulation of intracellular protein transport GO:0033157 64 36 0,000 0,04949728 0,05968346 ! development of primary male sexual characteristics GO:0046546 52 36 0,000 0,04949728 0,05965315 ! spliceosome assembly GO:0000245 65 36 0,000 0,04949728 0,05962287 ! mismatch repair GO:0006298 42 36 0,000 0,04949728 0,05959262 ! regulation of action potential in neuron GO:0019228 60 36 0,000 0,04949728 0,0595624 ! glycerol ether metabolic process GO:0006662 49 36 0,000 0,04949728 0,05953221 ! regulation of proteolysis GO:0030162 53 36 0,000 0,04949728 0,05950205 ! energy coupled proton transport, down electrochemical gradient GO:0015985 55 36 0,000 0,04949728 0,05947192 GO:0015986|ATP synthesis coupled proton transport, ! glycogen metabolic process GO:0005977 53 36 0,000 0,04949728 0,05944182 ! dorsal/ventral pattern formation GO:0009953 50 36 0,000 0,04949728 0,05941176 ! regulation of smooth muscle cell proliferation GO:0048660 60 37 0,000 0,0508379 0,06099006 ! positive regulation of DNA metabolic process GO:0051054 64 37 0,000 0,0508379 0,06095925 ! mammary gland development GO:0030879 73 37 0,000 0,0508379 0,06092846 ! positive regulation of JAK-STAT cascade GO:0046427 49 37 0,000 0,0508379 0,0608977 ! ear morphogenesis GO:0042471 50 37 0,000 0,0508379 0,06086698 ! odontogenesis GO:0042476 60 37 0,000 0,0508379 0,06083628 ! negative regulation of binding GO:0051100 59 37 0,000 0,0508379 0,06080562 ! mitotic cell cycle checkpoint GO:0007093 74 37 0,000 0,0508379 0,06077499 ! tissue remodeling GO:0048771 65 37 0,000 0,0508379 0,06074438 ! carbohydrate homeostasis GO:0033500 45 37 0,000 0,0508379 0,06071381 GO:0042593|glucose homeostasis, ! natural killer cell activation GO:0030101 45 37 0,000 0,0508379 0,06068327 ! polyol metabolic process GO:0019751 47 37 0,000 0,0508379 0,06065276 ! androgen receptor signaling pathway GO:0030521 66 37 0,000 0,0508379 0,06062229 ! glucan metabolic process GO:0044042 54 37 0,000 0,0508379 0,06059184 GO:0006073|cellular glucan metabolic process, ! positive regulation of transcription factor activity GO:0051091 57 38 0,000 0,05217671 0,06215629 GO:0090047|positive regulation of transcription regulator activity, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 48 38 0,000 0,05217671 0,0621251 GO:0006956|complement activation, ! regulation of hormone secretion GO:0046883 54 38 0,000 0,05217671 0,06209394 ! regulation of neuron projection development GO:0010975 73 38 0,000 0,05217671 0,06206282 ! feeding behavior GO:0007631 50 38 0,000 0,05217671 0,06203172 ! organic ether metabolic process GO:0018904 51 38 0,000 0,05217671 0,06200066 ! antigen processing and presentation of peptide antigen GO:0048002 67 38 0,000 0,05217671 0,06196963 ! development of primary female sexual characteristics GO:0046545 59 38 0,000 0,05217671 0,06193863 GO:0046660|female sex differentiation, ! regulation of Rab protein signal transduction GO:0032483 58 38 0,000 0,05217671 0,06190766 GO:0032313|regulation of Rab GTPase activity, ! multicellular organismal macromolecule metabolic process GO:0044259 51 38 0,000 0,05217671 0,06187672 ! ion transmembrane transport GO:0034220 58 38 0,000 0,05217671 0,06184582 ! heterocycle biosynthetic process GO:0018130 49 38 0,000 0,05217671 0,06181494 ! ribonucleoside metabolic process GO:0009119 51 38 0,000 0,05217671 0,06178409 ! neuron migration GO:0001764 59 38 0,000 0,05217671 0,06175328 ! maintenance of protein location GO:0045185 72 38 0,000 0,05217671 0,06172249 ! pigment metabolic process GO:0042440 66 38 0,000 0,05217671 0,06169174 ! regulation of cell morphogenesis involved in differentiation GO:0010769 72 38 0,000 0,05217671 0,06166102 ! mRNA catabolic process GO:0006402 58 39 0,000 0,05351369 0,06320955 ! response to reactive oxygen species GO:0000302 64 39 0,000 0,05351369 0,0631781 ! neural tube development GO:0021915 58 39 0,000 0,05351369 0,06314668 ! polysaccharide biosynthetic process GO:0000271 51 39 0,000 0,05351369 0,0631153 ! regulation of protein stability GO:0031647 58 39 0,000 0,05351369 0,06308394 ! female gamete generation GO:0007292 50 39 0,000 0,05351369 0,06305262 ! aerobic respiration GO:0009060 56 39 0,000 0,05351369 0,06302133 ! response to xenobiotic stimulus GO:0009410 55 39 0,000 0,05351369 0,06299007 ! protein amino acid N-linked glycosylation GO:0006487 57 40 0,000 0,05484885 0,06452965 ! Notch signaling pathway GO:0007219 64 40 0,000 0,05484885 0,06449768 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 68 40 0,000 0,05484885 0,06446573 ! monocarboxylic acid transport GO:0015718 68 40 0,000 0,05484885 0,06443382 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 71 40 0,000 0,05484885 0,06440194 ! hormone-mediated signaling GO:0009755 57 40 0,000 0,05484885 0,06437009 ! alcohol biosynthetic process GO:0046165 48 40 0,000 0,05484885 0,06433827 ! phagocytosis GO:0006909 65 40 0,000 0,05484885 0,06430648 ! mesenchymal cell development GO:0014031 70 40 0,000 0,05484885 0,06427472 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! erythrocyte homeostasis GO:0034101 60 40 0,000 0,05484885 0,064243 ! B cell differentiation GO:0030183 70 40 0,000 0,05484885 0,0642113 ! pigmentation GO:0043473 81 40 0,000 0,05484885 0,06417964 ! developmental growth GO:0048589 70 40 0,000 0,05484885 0,06414801 ! synapse organization GO:0050808 61 40 0,000 0,05484885 0,06411641 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 61 41 0,000 0,05618219 0,06564271 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 72 41 0,000 0,05618219 0,0656104 ! detection of stimulus involved in sensory perception GO:0050906 55 41 0,000 0,05618219 0,06557813 ! regulation of epithelial cell proliferation GO:0050678 80 41 0,000 0,05618219 0,06554589 ! ATP synthesis coupled electron transport GO:0042773 50 41 0,000 0,05618219 0,06551368 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of protein secretion GO:0050708 55 41 0,000 0,05618219 0,0654815 ! cell growth GO:0016049 71 41 0,000 0,05618219 0,06544936 ! maintenance of location in cell GO:0051651 77 41 0,000 0,05618219 0,06541724 ! transforming growth factor beta receptor signaling pathway GO:0007179 59 42 0,000 0,05751372 0,0669348 ! regulation of nucleocytoplasmic transport GO:0046822 75 42 0,000 0,05751372 0,06690199 ! negative regulation of protein complex disassembly GO:0043242 78 42 0,000 0,05751372 0,06686921 ! cellular amide metabolic process GO:0043603 63 42 0,000 0,05751372 0,06683647 ! morphogenesis of embryonic epithelium GO:0016331 69 42 0,000 0,05751372 0,06680375 ! gliogenesis GO:0042063 85 42 0,000 0,05751372 0,06677107 ! endosome transport GO:0016197 74 42 0,000 0,05751372 0,06673842 ! male sex differentiation GO:0046661 62 42 0,000 0,05751372 0,0667058 ! double-strand break repair GO:0006302 75 42 0,000 0,05751372 0,06667321 ! regulation of myeloid cell differentiation GO:0045637 78 42 0,000 0,05751372 0,06664066 ! oxidoreduction coenzyme metabolic process GO:0006733 62 42 0,000 0,05751372 0,06660813 ! mitochondrial transport GO:0006839 66 43 0,000 0,05884344 0,06811487 ! protein amino acid lipidation GO:0006497 69 43 0,000 0,05884344 0,06808166 ! energy reserve metabolic process GO:0006112 67 43 0,000 0,05884344 0,06804848 ! response to calcium ion GO:0051592 65 43 0,000 0,05884344 0,06801534 ! regulation of tube size GO:0035150 69 43 0,000 0,05884344 0,06798222 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 78 43 0,000 0,05884344 0,06794914 ! positive regulation of DNA binding GO:0043388 65 43 0,000 0,05884344 0,06791609 ! T cell differentiation GO:0030217 78 43 0,000 0,05884344 0,06788308 ! icosanoid metabolic process GO:0006690 65 43 0,000 0,05884344 0,06785009 ! amino acid activation GO:0043038 61 43 0,000 0,05884344 0,06781714 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! positive regulation of protein transport GO:0051222 59 43 0,000 0,05884344 0,06778422 ! epithelial cell differentiation GO:0030855 64 44 0,000 0,06017135 0,06928026 ! cytoskeleton-dependent intracellular transport GO:0030705 78 44 0,000 0,06017135 0,06924666 ! peptide metabolic process GO:0006518 64 44 0,000 0,06017135 0,0692131 ! multicellular organismal metabolic process GO:0044236 57 44 0,000 0,06017135 0,06917956 ! inner ear development GO:0048839 66 44 0,000 0,06017135 0,06914606 ! regulation of lymphocyte mediated immunity GO:0002706 77 44 0,000 0,06017135 0,0691126 ! regulation of gene expression, epigenetic GO:0040029 86 44 0,000 0,06017135 0,06907916 ! chromatin remodeling GO:0006338 73 44 0,000 0,06017135 0,06904575 ! biopolymer methylation GO:0043414 67 44 0,000 0,06017135 0,06901238 ! JNK cascade GO:0007254 66 44 0,000 0,06017135 0,06897904 ! JAK-STAT cascade GO:0007259 62 44 0,000 0,06017135 0,06894574 ! regulation of cell shape GO:0008360 83 44 0,000 0,06017135 0,06891246 ! activation of adenylate cyclase activity GO:0007190 79 45 0,000 0,06149746 0,07039723 ! positive regulation of binding GO:0051099 67 45 0,000 0,06149746 0,07036329 ! stress-activated protein kinase signaling pathway GO:0031098 69 45 0,000 0,06149746 0,07032938 ! regulation of ion transport GO:0043269 60 45 0,000 0,06149746 0,0702955 ! glucose transport GO:0015758 60 45 0,000 0,06149746 0,07026166 ! neuromuscular process GO:0050905 89 45 0,000 0,06149746 0,07022785 ! positive regulation of cytokine biosynthetic process GO:0042108 61 45 0,000 0,06149746 0,07019407 ! glycosaminoglycan metabolic process GO:0030203 68 45 0,000 0,06149746 0,07016032 ! regulation of T cell differentiation GO:0045580 68 45 0,000 0,06149746 0,07012661 ! regulation of actin filament polymerization GO:0030833 71 46 0,000 0,06282176 0,07160232 ! regulation of translational initiation GO:0006446 70 46 0,000 0,06282176 0,07156794 ! regulation of JAK-STAT cascade GO:0046425 68 46 0,000 0,06282176 0,0715336 ! regulation of action potential GO:0001508 80 46 0,000 0,06282176 0,07149929 ! hexose transport GO:0008645 62 46 0,000 0,06282176 0,07146502 GO:0015749|monosaccharide transport, ! activation of caspase activity GO:0006919 70 46 0,000 0,06282176 0,07143078 ! excretion GO:0007588 72 46 0,000 0,06282176 0,07139656 ! regulation of leukocyte mediated immunity GO:0002703 80 46 0,000 0,06282176 0,07136239 ! regulation of inflammatory response GO:0050727 74 46 0,000 0,06282176 0,07132824 ! epithelial tube morphogenesis GO:0060562 73 46 0,000 0,06282176 0,07129413 ! positive regulation of defense response GO:0031349 70 47 0,000 0,06414425 0,07276019 ! branching morphogenesis of a tube GO:0048754 85 47 0,000 0,06414425 0,07272542 ! embryonic skeletal system development GO:0048706 65 47 0,000 0,06414425 0,07269069 ! unsaturated fatty acid metabolic process GO:0033559 71 47 0,000 0,06414425 0,072656 ! lipoprotein biosynthetic process GO:0042158 74 47 0,000 0,06414425 0,07262133 ! regulation of JNK cascade GO:0046328 72 47 0,000 0,06414425 0,0725867 ! positive regulation of adenylate cyclase activity GO:0045762 90 48 0,000 0,06546495 0,07404591 ! viral infectious cycle GO:0019058 80 48 0,000 0,06546495 0,07401064 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 75 48 0,000 0,06546495 0,07397539 ! leukocyte migration GO:0050900 76 48 0,000 0,06546495 0,07394019 ! cellular amino acid biosynthetic process GO:0008652 60 48 0,000 0,06546495 0,07390501 ! striated muscle contraction GO:0006941 78 48 0,000 0,06546495 0,07386987 ! vascular process in circulatory system GO:0003018 78 48 0,000 0,06546495 0,07383476 ! DNA-dependent DNA replication GO:0006261 73 48 0,000 0,06546495 0,07379968 ! tRNA processing GO:0008033 56 48 0,000 0,06546495 0,07376464 ! cell maturation GO:0048469 69 48 0,000 0,06546495 0,07372963 ! detection of abiotic stimulus GO:0009582 66 48 0,000 0,06546495 0,07369465 ! respiratory electron transport chain GO:0022904 63 49 0,000 0,06678385 0,07514371 ! regulation of cell projection organization GO:0031344 95 49 0,000 0,06678385 0,07510809 ! glycolysis GO:0006096 63 49 0,000 0,06678385 0,07507252 ! regulation of gene-specific transcription GO:0032583 78 49 0,000 0,06678385 0,07503697 ! regulation of protein complex disassembly GO:0043244 88 49 0,000 0,06678385 0,07500146 ! response to temperature stimulus GO:0009266 66 49 0,000 0,06678385 0,07496598 ! endocrine system development GO:0035270 86 49 0,000 0,06678385 0,07493053 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,06678385 0,07489512 ! generation of a signal involved in cell-cell signaling GO:0003001 74 49 0,000 0,06678385 0,07485974 ! gastrulation GO:0007369 80 49 0,000 0,06678385 0,0748244 ! RNA elongation from RNA polymerase II promoter GO:0006368 65 49 0,000 0,06678385 0,07478909 ! positive regulation of cyclase activity GO:0031281 91 49 0,000 0,06678385 0,07475381 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 84 49 0,000 0,06678385 0,07471857 ! regulation of intracellular transport GO:0032386 83 49 0,000 0,06678385 0,07468336 ! methylation GO:0032259 74 49 0,000 0,06678385 0,07464818 ! cell redox homeostasis GO:0045454 72 50 0,000 0,06810096 0,07608454 ! negative regulation of cell migration GO:0030336 105 50 0,000 0,06810096 0,07604874 ! regulation of muscle contraction GO:0006937 75 50 0,000 0,06810096 0,07601297 ! cellular polysaccharide metabolic process GO:0044264 70 50 0,000 0,06810096 0,07597723 ! histone modification GO:0016570 81 50 0,000 0,06810096 0,07594153 ! positive regulation of lyase activity GO:0051349 92 50 0,000 0,06810096 0,07590586 ! heterocycle catabolic process GO:0046700 74 50 0,000 0,06810096 0,07587022 ! RNA catabolic process GO:0006401 77 51 0,000 0,06941627 0,0772993 ! chloride transport GO:0006821 78 51 0,000 0,06941627 0,07726304 ! positive regulation of caspase activity GO:0043280 77 51 0,000 0,06941627 0,07722682 GO:0010952|positive regulation of peptidase activity, ! membrane fusion GO:0006944 82 51 0,000 0,06941627 0,07719063 ! regulation of ossification GO:0030278 82 51 0,000 0,06941627 0,07715448 ! heart morphogenesis GO:0003007 71 51 0,000 0,06941627 0,07711836 ! RNA elongation GO:0006354 67 51 0,000 0,06941627 0,07708227 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 74 51 0,000 0,06941627 0,07704621 ! aminoglycan metabolic process GO:0006022 77 52 0,000 0,07072979 0,07846741 ! activation of phospholipase C activity GO:0007202 93 52 0,000 0,07072979 0,07843075 GO:0010863|positive regulation of phospholipase C activity, ! regulation of DNA replication GO:0006275 88 52 0,000 0,07072979 0,07839411 ! immunoglobulin mediated immune response GO:0016064 72 52 0,000 0,07072979 0,07835751 GO:0019724|B cell mediated immunity, ! cell recognition GO:0008037 78 52 0,000 0,07072979 0,07832095 ! covalent chromatin modification GO:0016569 90 52 0,000 0,07072979 0,07828442 ! regulation of adaptive immune response GO:0002819 90 52 0,000 0,07072979 0,07824792 ! proton transport GO:0015992 78 52 0,000 0,07072979 0,07821146 ! transition metal ion transport GO:0000041 88 53 0,000 0,07204153 0,07962484 ! regulation of angiogenesis GO:0045765 105 53 0,000 0,07204153 0,07958778 ! sulfur compound biosynthetic process GO:0044272 71 53 0,000 0,07204153 0,07955074 ! positive regulation of phospholipase activity GO:0010518 94 53 0,000 0,07204153 0,07951374 ! regulation of multicellular organism growth GO:0040014 72 53 0,000 0,07204153 0,07947677 ! regulation of endocytosis GO:0030100 71 53 0,000 0,07204153 0,07943984 ! regulation of lymphocyte differentiation GO:0045619 84 53 0,000 0,07204153 0,07940295 ! glutamine family amino acid metabolic process GO:0009064 71 53 0,000 0,07204153 0,07936608 ! cellular amino acid derivative biosynthetic process GO:0042398 73 53 0,000 0,07204153 0,07932925 ! maintenance of location GO:0051235 94 53 0,000 0,07204153 0,07929246 ! hydrogen transport GO:0006818 81 54 0,000 0,07335148 0,08069682 ! response to estrogen stimulus GO:0043627 88 54 0,000 0,07335148 0,08065943 ! positive regulation of cell migration GO:0030335 100 54 0,000 0,07335148 0,08062207 ! negative regulation of cytoskeleton organization GO:0051494 96 54 0,000 0,07335148 0,08058475 ! regulation of actin polymerization or depolymerization GO:0008064 81 54 0,000 0,07335148 0,08054746 ! nucleotide-excision repair GO:0006289 70 54 0,000 0,07335148 0,0805102 ! sphingolipid metabolic process GO:0006665 80 54 0,000 0,07335148 0,08047298 ! ribonucleoprotein complex assembly GO:0022618 90 54 0,000 0,07335148 0,08043579 ! morphogenesis of a branching structure GO:0001763 99 54 0,000 0,07335148 0,08039864 ! germ cell development GO:0007281 82 54 0,000 0,07335148 0,08036152 ! positive regulation of cytokine production GO:0001819 83 54 0,000 0,07335148 0,08032444 ! regulation of protein polymerization GO:0032271 84 54 0,000 0,07335148 0,08028739 ! glycerophospholipid biosynthetic process GO:0046474 82 55 0,000 0,07465964 0,08168157 ! ear development GO:0043583 83 55 0,000 0,07465964 0,08164393 ! regulation of phospholipase activity GO:0010517 96 55 0,000 0,07465964 0,08160632 ! regulation of protein catabolic process GO:0042176 83 55 0,000 0,07465964 0,08156875 ! integrin-mediated signaling pathway GO:0007229 93 55 0,000 0,07465964 0,08153121 ! positive regulation of lipase activity GO:0060193 96 55 0,000 0,07465964 0,08149371 ! regulation of actin filament length GO:0030832 88 56 0,000 0,07596603 0,08288155 ! positive regulation of secretion GO:0051047 83 56 0,000 0,07596603 0,08284346 ! nucleoside metabolic process GO:0009116 74 56 0,000 0,07596603 0,08280541 ! adult behavior GO:0030534 90 56 0,000 0,07596603 0,08276739 ! cartilage development GO:0051216 84 56 0,000 0,07596603 0,08272941 ! regulation of neurotransmitter levels GO:0001505 85 57 0,000 0,07727063 0,08411156 ! mesoderm development GO:0007498 84 57 0,000 0,07727063 0,084073 ! cellular amino acid catabolic process GO:0009063 82 57 0,000 0,07727063 0,08403447 ! single fertilization GO:0007338 67 57 0,000 0,07727063 0,08399597 ! regulation of cellular component size GO:0032535 90 58 0,000 0,07857346 0,08537309 ! lipid modification GO:0030258 82 58 0,000 0,07857346 0,08533402 ! membrane lipid metabolic process GO:0006643 88 58 0,000 0,07857346 0,08529498 ! negative regulation of cell motion GO:0051271 118 58 0,000 0,07857346 0,08525598 ! regulation of bone remodeling GO:0046850 102 59 0,000 0,07987452 0,08662808 ! viral reproductive process GO:0022415 99 59 0,000 0,07987452 0,0865885 ! skeletal system morphogenesis GO:0048705 90 59 0,000 0,07987452 0,08654896 ! chromosome segregation GO:0007059 93 59 0,000 0,07987452 0,08650946 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,07987452 0,08647 ! negative regulation of response to stimulus GO:0048585 88 59 0,000 0,07987452 0,08643057 ! cell projection assembly GO:0030031 90 59 0,000 0,07987452 0,08639117 ! glucose catabolic process GO:0006007 78 60 0,000 0,0811738 0,08775646 ! regulation of lipid metabolic process GO:0019216 93 60 0,000 0,0811738 0,0877165 ! water-soluble vitamin metabolic process GO:0006767 84 60 0,000 0,0811738 0,08767657 ! kidney development GO:0001822 101 60 0,000 0,0811738 0,08763669 ! positive regulation of cell motion GO:0051272 110 60 0,000 0,0811738 0,08759683 ! regulation of protein complex assembly GO:0043254 95 61 0,000 0,08247132 0,08895656 ! carbohydrate transport GO:0008643 83 61 0,000 0,08247132 0,08891615 ! protein maturation by peptide bond cleavage GO:0051605 86 61 0,000 0,08247132 0,08887577 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 98 62 0,000 0,08376707 0,09023116 ! amino acid transport GO:0006865 97 62 0,000 0,08376707 0,09019022 ! activation of MAPK activity GO:0000187 95 62 0,000 0,08376707 0,09014932 ! multicellular organism reproduction GO:0032504 98 62 0,000 0,08376707 0,09010845 GO:0048609|reproductive process in a multicellular organism, ! lipoprotein metabolic process GO:0042157 96 62 0,000 0,08376707 0,09006763 ! glycerolipid biosynthetic process GO:0045017 92 62 0,000 0,08376707 0,09002683 ! detection of external stimulus GO:0009581 78 62 0,000 0,08376707 0,08998608 ! regulation of tissue remodeling GO:0034103 113 62 0,000 0,08376707 0,08994536 ! secondary metabolic process GO:0019748 95 62 0,000 0,08376707 0,08990468 ! gonad development GO:0008406 91 62 0,000 0,08376707 0,08986404 ! exocytosis GO:0006887 91 63 0,000 0,08506105 0,09121097 ! oxygen and reactive oxygen species metabolic process GO:0006800 89 63 0,000 0,08506105 0,09116977 ! embryonic limb morphogenesis GO:0030326 96 63 0,000 0,08506105 0,09112861 GO:0035113|embryonic appendage morphogenesis, ! coenzyme biosynthetic process GO:0009108 81 63 0,000 0,08506105 0,09108749 ! regulation of heart contraction GO:0008016 104 63 0,000 0,08506105 0,0910464 ! developmental maturation GO:0021700 90 63 0,000 0,08506105 0,09100535 ! fertilization GO:0009566 79 64 0,000 0,08635327 0,09234624 ! viral reproduction GO:0016032 104 64 0,000 0,08635327 0,09230465 ! myeloid cell differentiation GO:0030099 101 64 0,000 0,08635327 0,09226309 ! amine catabolic process GO:0009310 100 65 0,000 0,08764373 0,09359972 ! camera-type eye development GO:0043010 103 65 0,000 0,08764373 0,09355762 ! steroid hormone receptor signaling pathway GO:0030518 116 65 0,000 0,08764373 0,09351555 ! regulation of lipase activity GO:0060191 117 65 0,000 0,08764373 0,09347352 ! regulation of homeostatic process GO:0032844 122 65 0,000 0,08764373 0,09343153 ! regulation of transcription factor activity GO:0051090 109 66 0,000 0,08893244 0,09476276 GO:0090046|regulation of transcription regulator activity, ! cellular hormone metabolic process GO:0034754 95 66 0,000 0,08893244 0,09472023 ! sensory perception of smell GO:0007608 81 66 0,000 0,08893244 0,09467774 ! regulation of cytokine biosynthetic process GO:0042035 91 66 0,000 0,08893244 0,09463528 ! cAMP-mediated signaling GO:0019933 109 66 0,000 0,08893244 0,09459286 ! lung development GO:0030324 112 66 0,000 0,08893244 0,09455048 ! lymphocyte mediated immunity GO:0002449 95 66 0,000 0,08893244 0,09450814 ! B cell activation GO:0042113 119 66 0,000 0,08893244 0,09446583 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 97 66 0,000 0,08893244 0,09442357 ! neurotransmitter transport GO:0006836 92 67 0,000 0,09021939 0,09574714 ! regulation of cellular response to stress GO:0080135 100 67 0,000 0,09021939 0,09570434 ! appendage morphogenesis GO:0035107 103 67 0,000 0,09021939 0,09566157 GO:0035108|limb morphogenesis, ! fatty acid biosynthetic process GO:0006633 107 67 0,000 0,09021939 0,09561885 ! extracellular matrix organization GO:0030198 117 67 0,000 0,09021939 0,09557616 ! negative regulation of ligase activity GO:0051352 100 67 0,000 0,09021939 0,09553351 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! meiosis GO:0007126 110 68 0,000 0,09150458 0,09685119 GO:0051327|M phase of meiotic cell cycle, ! phosphoinositide metabolic process GO:0030384 100 68 0,000 0,09150458 0,09680801 ! positive regulation of protein amino acid phosphorylation GO:0001934 103 68 0,000 0,09150458 0,09676487 ! defense response to bacterium GO:0042742 79 68 0,000 0,09150458 0,09672177 ! regulation of vesicle-mediated transport GO:0060627 98 68 0,000 0,09150458 0,0966787 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 109 68 0,000 0,09150458 0,09663568 ! activation of immune response GO:0002253 93 68 0,000 0,09150458 0,09659269 ! appendage development GO:0048736 108 69 0,000 0,09278803 0,09790395 GO:0060173|limb development, ! respiratory tube development GO:0030323 117 69 0,000 0,09278803 0,09786044 ! urogenital system development GO:0001655 114 69 0,000 0,09278803 0,09781696 ! meiotic cell cycle GO:0051321 111 69 0,000 0,09278803 0,09777353 ! hexose catabolic process GO:0019320 95 70 0,000 0,09406972 0,09908009 ! adaptive immune response GO:0002250 102 70 0,000 0,09406972 0,09903614 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 104 71 0,000 0,09534967 0,10033914 ! cell-matrix adhesion GO:0007160 133 71 0,000 0,09534967 0,10029467 ! elevation of cytosolic calcium ion concentration GO:0007204 126 71 0,000 0,09534967 0,10025023 ! axon guidance GO:0007411 116 71 0,000 0,09534967 0,10020583 ! intracellular receptor-mediated signaling pathway GO:0030522 124 71 0,000 0,09534967 0,10016147 ! response to drug GO:0042493 115 72 0,000 0,09662788 0,10145927 ! cytosolic calcium ion homeostasis GO:0051480 128 72 0,000 0,09662788 0,1014144 ! positive regulation of T cell activation GO:0050870 117 72 0,000 0,09662788 0,10136956 ! respiratory system development GO:0060541 123 72 0,000 0,09662788 0,10132477 ! rhythmic process GO:0048511 113 72 0,000 0,09662788 0,10128001 ! regulation of immune effector process GO:0002697 121 72 0,000 0,09662788 0,1012353 ! humoral immune response GO:0006959 93 73 0,000 0,09790434 0,10252736 ! regulation of MAPKKK cascade GO:0043408 123 73 0,000 0,09790434 0,10248214 ! acute inflammatory response GO:0002526 107 74 0,000 0,09917907 0,10377069 ! development of primary sexual characteristics GO:0045137 107 74 0,000 0,09917907 0,10372496 ! transcription initiation from RNA polymerase II promoter GO:0006367 100 74 0,000 0,09917907 0,10367926 ! regulation of neuron differentiation GO:0045664 130 74 0,000 0,09917907 0,10363361 ! leukocyte mediated immunity GO:0002443 107 75 0,000 0,10045206 0,10491757 ! positive regulation of phosphorylation GO:0042327 119 75 0,000 0,10045206 0,10487142 ! inorganic anion transport GO:0015698 109 75 0,000 0,10045206 0,1048253 ! lymphocyte differentiation GO:0030098 135 75 0,000 0,10045206 0,10477922 ! regulation of catabolic process GO:0009894 114 75 0,000 0,10045206 0,10473318 ! response to metal ion GO:0010038 114 76 0,000 0,10172331 0,10601204 ! phospholipid biosynthetic process GO:0008654 109 76 0,000 0,10172331 0,1059655 ! phosphoinositide-mediated signaling GO:0048015 122 76 0,000 0,10172331 0,105919 ! cell-substrate adhesion GO:0031589 141 76 0,000 0,10172331 0,10587255 ! negative regulation of transport GO:0051051 122 77 0,000 0,10299283 0,10714686 ! cellular lipid catabolic process GO:0044242 117 77 0,000 0,10299283 0,10709991 ! positive regulation of phosphorus metabolic process GO:0010562 125 77 0,000 0,10299283 0,10705299 GO:0045937|positive regulation of phosphate metabolic process, ! response to nutrient GO:0007584 114 77 0,000 0,10299283 0,10700612 ! monosaccharide catabolic process GO:0046365 104 77 0,000 0,10299283 0,10695929 ! regulation of blood pressure GO:0008217 119 78 0,000 0,10426062 0,10822854 ! amine transport GO:0015837 115 78 0,000 0,10426062 0,10818122 ! antigen processing and presentation GO:0019882 114 78 0,000 0,10426062 0,10813394 ! steroid biosynthetic process GO:0006694 111 79 0,000 0,10552668 0,10939922 ! regulation of adenylate cyclase activity GO:0045761 143 80 0,000 0,10679102 0,11066161 ! regulation of DNA binding GO:0051101 130 80 0,000 0,10679102 0,11061331 ! tube morphogenesis GO:0035239 140 80 0,000 0,10679102 0,11056505 ! response to unfolded protein GO:0006986 113 80 0,000 0,10679102 0,11051683 ! intracellular protein transmembrane transport GO:0065002 115 80 0,000 0,10679102 0,11046865 ! protein ubiquitination GO:0016567 135 80 0,000 0,10679102 0,11042052 ! negative regulation of organelle organization GO:0010639 136 80 0,000 0,10679102 0,11037243 ! blood coagulation GO:0007596 129 81 0,000 0,10805363 0,11162876 GO:0050817|coagulation, ! amine biosynthetic process GO:0009309 108 81 0,000 0,10805363 0,11158019 ! response to inorganic substance GO:0010035 127 81 0,000 0,10805363 0,11153165 ! oxidative phosphorylation GO:0006119 110 81 0,000 0,10805363 0,11148316 ! nitrogen compound catabolic process GO:0044270 125 81 0,000 0,10805363 0,11143471 ! response to hypoxia GO:0001666 155 81 0,000 0,10805363 0,1113863 ! regulation of protein transport GO:0051223 123 81 0,000 0,10805363 0,11133794 GO:0070201|regulation of establishment of protein localization, ! regulation of cAMP biosynthetic process GO:0030817 148 82 0,000 0,10931453 0,11258827 ! neuropeptide signaling pathway GO:0007218 101 82 0,000 0,10931453 0,11253942 ! regulation of cell morphogenesis GO:0022604 155 82 0,000 0,10931453 0,11249062 ! regulation of cyclase activity GO:0031279 146 82 0,000 0,10931453 0,11244186 ! cholesterol metabolic process GO:0008203 120 83 0,000 0,1105737 0,11368778 ! positive regulation of protein modification process GO:0031401 126 83 0,000 0,1105737 0,11363854 ! response to oxygen levels GO:0070482 160 83 0,000 0,1105737 0,11358935 ! regulation of lyase activity GO:0051339 147 83 0,000 0,1105737 0,11354019 ! cofactor biosynthetic process GO:0051188 108 83 0,000 0,1105737 0,11349109 ! regulation of cAMP metabolic process GO:0030814 153 84 0,000 0,11183116 0,11473209 ! digestion GO:0007586 111 84 0,000 0,11183116 0,11468251 ! ATP biosynthetic process GO:0006754 131 84 0,000 0,11183116 0,11463297 ! cellular respiration GO:0045333 119 85 0,000 0,1130869 0,11587013 ! biogenic amine metabolic process GO:0006576 128 85 0,000 0,1130869 0,11582012 ! T cell activation GO:0042110 154 85 0,000 0,1130869 0,11577015 ! sex differentiation GO:0007548 126 85 0,000 0,1130869 0,11572023 ! protein import into nucleus GO:0006606 145 85 0,000 0,1130869 0,11567035 ! response to protein stimulus GO:0051789 127 85 0,000 0,1130869 0,11562051 ! one-carbon metabolic process GO:0006730 126 85 0,000 0,1130869 0,11557072 ! alcohol catabolic process GO:0046164 119 86 0,000 0,11434093 0,11680199 ! carbohydrate biosynthetic process GO:0016051 111 86 0,000 0,11434093 0,11675173 ! regulation of nucleotide biosynthetic process GO:0030808 155 87 0,000 0,11559325 0,11797969 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! hemostasis GO:0007599 138 87 0,000 0,11559325 0,11792897 ! regulation of defense response GO:0031347 135 87 0,000 0,11559325 0,11787829 ! tRNA metabolic process GO:0006399 110 87 0,000 0,11559325 0,11782766 ! sensory perception of chemical stimulus GO:0007606 108 87 0,000 0,11559325 0,11777706 ! gland development GO:0048732 170 87 0,000 0,11559325 0,11772652 ! vitamin metabolic process GO:0006766 117 87 0,000 0,11559325 0,11767601 ! forebrain development GO:0030900 151 87 0,000 0,11559325 0,11762555 ! regulation of membrane potential GO:0042391 144 88 0,000 0,11684386 0,11884719 ! ossification GO:0001503 150 89 0,000 0,11809277 0,12006604 GO:0060348|bone development, ! nucleosome assembly GO:0006334 113 89 0,000 0,11809277 0,12001462 GO:0031497|chromatin assembly, ! regulation of DNA metabolic process GO:0051052 152 90 0,000 0,11933998 0,12123021 ! microtubule cytoskeleton organization GO:0000226 133 90 0,000 0,11933998 0,12117833 ! regulation of cyclic nucleotide metabolic process GO:0030799 161 90 0,000 0,11933998 0,1211265 ! nuclear import GO:0051170 153 90 0,000 0,11933998 0,12107472 ! regulation of protein localization GO:0032880 141 90 0,000 0,11933998 0,12102298 ! carboxylic acid catabolic process GO:0046395 132 91 0,000 0,12058548 0,12223381 GO:0016054|organic acid catabolic process, ! detection of stimulus GO:0051606 123 91 0,000 0,12058548 0,12218162 ! protein localization in nucleus GO:0034504 161 92 0,000 0,12182928 0,1233892 ! sterol metabolic process GO:0016125 136 92 0,000 0,12182928 0,12333656 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 141 93 0,000 0,12307139 0,1245409 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! protein-DNA complex assembly GO:0065004 119 93 0,000 0,12307139 0,12448782 ! rRNA processing GO:0006364 124 93 0,000 0,12307139 0,12443477 ! regulation of nucleotide metabolic process GO:0006140 164 93 0,000 0,12307139 0,12438178 ! anterior/posterior pattern formation GO:0009952 141 93 0,000 0,12307139 0,12432883 ! negative regulation of multicellular organismal process GO:0051241 150 93 0,000 0,12307139 0,12427592 ! leukocyte differentiation GO:0002521 165 94 0,000 0,12431181 0,12547508 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 140 94 0,000 0,12431181 0,12542173 ! ribonucleoside triphosphate biosynthetic process GO:0009201 142 94 0,000 0,12431181 0,12536843 ! rRNA metabolic process GO:0016072 125 94 0,000 0,12431181 0,12531517 ! hormone metabolic process GO:0042445 135 94 0,000 0,12431181 0,12526196 ! protein processing GO:0016485 127 94 0,000 0,12431181 0,12520879 ! nucleoside triphosphate biosynthetic process GO:0009142 143 95 0,000 0,12555053 0,1264028 ! anatomical structure homeostasis GO:0060249 152 95 0,000 0,12555053 0,1263492 ! ATP metabolic process GO:0046034 150 96 0,000 0,12678756 0,12754001 ! nucleosome organization GO:0034728 126 96 0,000 0,12678756 0,12748597 ! protein modification by small protein conjugation GO:0032446 153 96 0,000 0,12678756 0,12743197 ! female pregnancy GO:0007565 148 96 0,000 0,12678756 0,12737802 ! regulation of neurogenesis GO:0050767 179 97 0,000 0,12802291 0,12856469 ! reproductive developmental process GO:0003006 149 97 0,000 0,12802291 0,1285103 ! response to virus GO:0009615 141 98 0,000 0,12925657 0,1296938 ! polysaccharide metabolic process GO:0005976 141 98 0,000 0,12925657 0,12963898 ! Wnt receptor signaling pathway GO:0016055 161 98 0,000 0,12925657 0,12958421 ! regulation of binding GO:0051098 164 99 0,000 0,13048854 0,13076407 ! electron transport chain GO:0022900 135 99 0,000 0,13048854 0,13070887 ! glycerophospholipid metabolic process GO:0006650 143 99 0,000 0,13048854 0,13065372 ! positive regulation of immune response GO:0050778 143 99 0,000 0,13048854 0,13059861 ! sulfur metabolic process GO:0006790 136 99 0,000 0,13048854 0,13054356 ! carbohydrate catabolic process GO:0016052 137 100 0,000 0,13171884 0,13171884