pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a2/out-0.05-06-0.01-300-run-a2//th1-pval-1e-01-11-th2-pval-1e-02-02-th3-pval-1e-01-02-run-a2/go_data/2901-3-real-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! alcohol catabolic process GO:0046164 104 80 5,000 5,1E-09 1,173E-05 ! carbohydrate catabolic process GO:0016052 121 93 5,000 1,273E-08 1,464E-05 ! polyol catabolic process GO:0046174 7 5 2,000 5,037E-08 3,861E-05 GO:0019405|alditol catabolic process, ! substrate-bound cell migration, cell extension GO:0006930 5 5 2,000 5,037E-08 2,896E-05 ! substrate-bound cell migration GO:0006929 10 9 2,000 4,21E-07 1,937E-04 ! cellular carbohydrate catabolic process GO:0044275 13 11 2,000 8,251E-07 3,163E-04 ! glycolysis GO:0006096 53 44 3,000 1,045E-06 3,433E-04 ! glucose catabolic process GO:0006007 66 54 3,000 2,404E-06 6,913E-04 ! fructose metabolic process GO:0006000 20 16 2,000 2,783E-06 7,113E-04 ! hexose catabolic process GO:0019320 82 64 3,000 4,771E-06 1,097E-03 ! alditol metabolic process GO:0019400 24 20 2,000 5,639E-06 1,179E-03 ! monosaccharide catabolic process GO:0046365 91 71 3,000 7,234E-06 1,386E-03 ! sperm motility GO:0030317 27 24 2,000 9,964E-06 1,763E-03 ! hexose biosynthetic process GO:0019319 35 29 2,000 1,788E-05 2,938E-03 ! monosaccharide biosynthetic process GO:0046364 38 32 2,000 2,418E-05 3,708E-03 ! cytokinesis GO:0000910 52 33 2,000 2,657E-05 3,82E-03 ! polyol metabolic process GO:0019751 44 34 2,000 2,911E-05 3,938E-03 ! negative regulation of protein ubiquitination GO:0031397 7 5 1,000 3,033E-05 3,876E-03 ! skeletal myofibril assembly GO:0014866 7 5 1,000 3,033E-05 3,672E-03 ! positive regulation of Rho GTPase activity GO:0032321 9 5 1,000 3,033E-05 3,488E-03 ! neural plate development GO:0001840 6 5 1,000 3,033E-05 3,322E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 3,033E-05 3,171E-03 ! alcohol biosynthetic process GO:0046165 45 38 2,000 4,084E-05 4,084E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 6,355E-05 6,091E-03 ! synaptic transmission, glutamatergic GO:0035249 13 7 1,000 6,355E-05 5,847E-03 ! protein retention in ER lumen GO:0006621 12 7 1,000 6,355E-05 5,622E-03 ! regulation of focal adhesion formation GO:0051893 17 7 1,000 6,355E-05 5,414E-03 ! positive regulation of cell cycle GO:0045787 77 45 2,000 6,812E-05 5,595E-03 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 8,464E-05 6,713E-03 ! positive regulation of organelle organization GO:0010638 82 51 2,000 9,925E-05 7,609E-03 ! positive regulation of GTPase activity GO:0043547 21 9 1,000 1,087E-04 8,065E-03 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 1,000 1,087E-04 7,813E-03 ! regulation of stress fiber formation GO:0051492 20 9 1,000 1,087E-04 7,577E-03 ! receptor clustering GO:0043113 15 9 1,000 1,087E-04 7,354E-03 ! establishment of cell polarity GO:0030010 12 9 1,000 1,087E-04 7,144E-03 ! cell projection assembly GO:0030031 76 53 2,000 1,114E-04 7,116E-03 ! regulation of phosphatase activity GO:0010921 21 10 1,000 1,357E-04 8,438E-03 ! regulation of actin filament bundle formation GO:0032231 21 10 1,000 1,357E-04 8,216E-03 ! actin filament organization GO:0007015 95 59 2,000 1,535E-04 9,05E-03 ! regulation of Rho GTPase activity GO:0032319 18 11 1,000 1,657E-04 9,529E-03 ! regulation of actin cytoskeleton organization GO:0032956 97 64 2,000 1,955E-04 0,01096662 ! regulation of actin filament-based process GO:0032970 99 66 2,000 2,142E-04 0,0117298 ! axon guidance GO:0007411 99 66 2,000 2,142E-04 0,01145702 ! regulation of exocytosis GO:0017157 17 13 1,000 2,345E-04 0,01225776 ! regulation of protein ubiquitination GO:0031396 19 15 1,000 3,15E-04 0,01609852 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 3,15E-04 0,01574855 ! regulation of neurotransmitter secretion GO:0046928 26 15 1,000 3,15E-04 0,01541347 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 1,000 3,15E-04 0,01509236 ! response to unfolded protein GO:0006986 99 76 2,000 3,251E-04 0,01526177 ! carbohydrate biosynthetic process GO:0016051 97 77 2,000 3,379E-04 0,01554423 ! cellular response to unfolded protein GO:0034620 19 16 1,000 3,596E-04 0,01621587 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of dephosphorylation GO:0035303 33 16 1,000 3,596E-04 0,01590402 ! neural crest cell migration GO:0001755 24 16 1,000 3,596E-04 0,01560395 ! negative regulation of translation GO:0017148 22 16 1,000 3,596E-04 0,01531499 ! response to protein stimulus GO:0051789 111 81 2,000 3,923E-04 0,01640326 ! signal complex assembly GO:0007172 29 17 1,000 4,071E-04 0,0167186 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 4,574E-04 0,01845805 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 4,574E-04 0,01813981 ! regulation of postsynaptic membrane potential GO:0060078 30 19 1,000 5,107E-04 0,01990827 ! regulation of neurotransmitter transport GO:0051588 35 20 1,000 5,668E-04 0,02172761 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 5,881E-04 0,02217312 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 6,258E-04 0,02321439 ! nerve-nerve synaptic transmission GO:0007270 36 21 1,000 6,258E-04 0,02284591 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 6,876E-04 0,02471053 GO:0010810|regulation of cell-substrate adhesion, ! membrane depolarization GO:0051899 35 22 1,000 6,876E-04 0,02433037 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 7,523E-04 0,02621482 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 7,523E-04 0,02582356 ! fat cell differentiation GO:0045444 37 24 1,000 8,197E-04 0,02772623 ! receptor metabolic process GO:0043112 37 24 1,000 8,197E-04 0,0273244 ! neural crest cell development GO:0014032 39 24 1,000 8,197E-04 0,02693405 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 1,000 8,197E-04 0,0265547 ! regulation of chromosome organization GO:0033044 35 25 1,000 8,9E-04 0,02843151 ! positive regulation of nuclear division GO:0051785 39 25 1,000 8,9E-04 0,02804203 GO:0045840|positive regulation of mitosis, ! negative regulation of protein modification process GO:0031400 50 26 1,000 9,631E-04 0,02993527 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 1,039E-03 0,03186383 ! myofibril assembly GO:0030239 36 27 1,000 1,039E-03 0,03144457 GO:0055002|striated muscle cell development, ! neural tube formation GO:0001841 41 28 1,000 1,118E-03 0,03338672 ! muscle cell development GO:0055001 38 29 1,000 1,199E-03 0,03536101 ! spindle organization GO:0007051 37 30 1,000 1,283E-03 0,03736595 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 1,283E-03 0,03689888 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 1,37E-03 0,0389137 ! maintenance of protein location in cell GO:0032507 60 31 1,000 1,37E-03 0,03843914 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 1,46E-03 0,04046307 ! meiosis I GO:0007127 52 32 1,000 1,46E-03 0,03998137 ! RNA export from nucleus GO:0006405 44 33 1,000 1,553E-03 0,04201371 ! sister chromatid segregation GO:0000819 46 33 1,000 1,553E-03 0,04152518 ! actomyosin structure organization GO:0031032 43 33 1,000 1,553E-03 0,04104788 ! establishment or maintenance of cell polarity GO:0007163 61 34 1,000 1,648E-03 0,04307022 ! maintenance of protein location GO:0045185 65 35 1,000 1,746E-03 0,04511747 ! Rho protein signal transduction GO:0007266 51 35 1,000 1,746E-03 0,04461616 ! neural tube development GO:0021915 50 36 1,000 1,847E-03 0,04667001 ! striated muscle cell differentiation GO:0051146 54 38 1,000 2,056E-03 0,05139823 ! mesenchymal cell development GO:0014031 64 38 1,000 2,056E-03 0,05084556 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 2,056E-03 0,05030465 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 2,165E-03 0,05240785 ! response to calcium ion GO:0051592 58 40 1,000 2,276E-03 0,05453135 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 2,507E-03 0,05944244 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 2,626E-03 0,06163794 ! response to insulin stimulus GO:0032868 63 43 1,000 2,626E-03 0,06101534 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 2,626E-03 0,06040518 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 3E-03 0,0683234 ! response to UV GO:0009411 75 46 1,000 3E-03 0,06765356 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 3,263E-03 0,072856 ! nuclear export GO:0051168 69 48 1,000 3,263E-03 0,07215546 ! maintenance of location GO:0051235 84 49 1,000 3,398E-03 0,07442742 ! regulation of actin filament length GO:0030832 72 50 1,000 3,535E-03 0,07671261 ! skeletal muscle fiber development GO:0048741 73 50 1,000 3,535E-03 0,07599567 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 3,676E-03 0,07827888 ! muscle fiber development GO:0048747 74 51 1,000 3,676E-03 0,07756072 ! regulation of cellular component size GO:0032535 74 52 1,000 3,819E-03 0,07984187 ! establishment of organelle localization GO:0051656 85 52 1,000 3,819E-03 0,07912257 ! regulation of mitosis GO:0007088 84 54 1,000 4,112E-03 0,08443936 GO:0051783|regulation of nuclear division, ! chromosome segregation GO:0007059 83 57 1,000 4,571E-03 0,09303436 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 4,571E-03 0,09221827 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 5,052E-03 0,10104862 ! meiosis GO:0007126 96 61 1,000 5,218E-03 0,10345945 GO:0051327|M phase of meiotic cell cycle, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 5,218E-03 0,10257518 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 5,386E-03 0,10498052 ! meiotic cell cycle GO:0051321 97 62 1,000 5,386E-03 0,10409833 ! organelle localization GO:0051640 96 62 1,000 5,386E-03 0,10323084 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 5,729E-03 0,10890525 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 5,905E-03 0,11131904 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 5,905E-03 0,110414 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 6,083E-03 0,11282202 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 6,446E-03 0,11859784 ! positive regulation of ligase activity GO:0051351 99 69 1,000 6,631E-03 0,12103557 ! response to metal ion GO:0010038 103 70 1,000 6,818E-03 0,12347855 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 6,818E-03 0,12251387 ! muscle cell differentiation GO:0042692 104 71 1,000 7,008E-03 0,12495032 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 7,008E-03 0,12398916 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 7,2E-03 0,12641915 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 7,2E-03 0,12546143 ! regulation of synaptic transmission GO:0050804 109 72 1,000 7,2E-03 0,12451811 ! tube morphogenesis GO:0035239 118 73 1,000 7,395E-03 0,12693066 ! blood coagulation GO:0007596 116 75 1,000 7,792E-03 0,13274577 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 7,792E-03 0,1317697 ! regulation of ligase activity GO:0051340 114 75 1,000 7,792E-03 0,13080787 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 8,198E-03 0,13662569 ! positive regulation of protein modification process GO:0031401 107 78 1,000 8,404E-03 0,13905948 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 8,824E-03 0,14496564 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 1,000 8,824E-03 0,14393751 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 8,836E-03 0,14311639 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 8,836E-03 0,14211557 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 8,836E-03 0,14112866 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 8,836E-03 0,14015536 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 8,836E-03 0,13919539 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 8,836E-03 0,13824848 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 8,836E-03 0,13731437 ! sleep GO:0030431 11 5 0,000 8,836E-03 0,1363928 ! negative regulation of bone resorption GO:0045779 10 5 0,000 8,836E-03 0,13548351 ! nucleotide-sugar transport GO:0015780 8 5 0,000 8,836E-03 0,13458627 ! regulation of interferon-beta production GO:0032648 5 5 0,000 8,836E-03 0,13370083 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 8,836E-03 0,13282697 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 8,836E-03 0,13196446 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 8,836E-03 0,13111308 ! tongue development GO:0043586 6 5 0,000 8,836E-03 0,13027261 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 8,836E-03 0,12944285 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 8,836E-03 0,12862359 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 8,836E-03 0,12781463 ! cobalt ion transport GO:0006824 9 5 0,000 8,836E-03 0,12701579 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 8,836E-03 0,12622687 ! SMAD protein complex assembly GO:0007183 9 5 0,000 8,836E-03 0,1254477 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 8,836E-03 0,12467808 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 8,836E-03 0,12391785 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 8,836E-03 0,12316683 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 8,836E-03 0,12242486 ! embryonic camera-type eye development GO:0031076 8 5 0,000 8,836E-03 0,12169178 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 8,836E-03 0,12096742 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 8,836E-03 0,12025164 ! adaptation of signaling pathway GO:0022401 7 5 0,000 8,836E-03 0,11954428 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 8,836E-03 0,11884519 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 8,836E-03 0,11815423 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 8,836E-03 0,11747125 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 8,836E-03 0,11679613 ! positive regulation of histone modification GO:0031058 5 5 0,000 8,836E-03 0,11612872 ! malate metabolic process GO:0006108 7 5 0,000 8,836E-03 0,1154689 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 8,836E-03 0,11481654 ! behavioral response to pain GO:0048266 7 5 0,000 8,836E-03 0,1141715 ! clathrin coat assembly GO:0048268 11 5 0,000 8,836E-03 0,11353367 ! phototransduction, visible light GO:0007603 6 5 0,000 8,836E-03 0,11290293 ! regulation of dopamine uptake GO:0051584 9 5 0,000 8,836E-03 0,11227915 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 8,836E-03 0,11166224 ! mating behavior GO:0007617 6 5 0,000 8,836E-03 0,11105206 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 8,836E-03 0,11044852 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 8,836E-03 0,1098515 ! rhythmic behavior GO:0007622 12 5 0,000 8,836E-03 0,1092609 ! copulation GO:0007620 7 5 0,000 8,836E-03 0,10867661 ! glial cell fate commitment GO:0021781 12 5 0,000 8,836E-03 0,10809855 ! protein maturation by protein folding GO:0022417 12 5 0,000 8,836E-03 0,1075266 ! embryonic hemopoiesis GO:0035162 10 5 0,000 8,836E-03 0,10696067 ! regulation of potassium ion transport GO:0043266 9 5 0,000 8,836E-03 0,10640066 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 8,836E-03 0,10584649 ! apoptotic cell clearance GO:0043277 13 5 0,000 8,836E-03 0,10529807 ! lipoprotein particle clearance GO:0034381 9 5 0,000 8,836E-03 0,10475529 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 8,836E-03 0,10421809 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 8,836E-03 0,10368636 ! response to protozoan GO:0001562 9 5 0,000 8,836E-03 0,10316003 ! positive regulation of glycolysis GO:0045821 11 5 0,000 8,836E-03 0,10263902 ! lymph vessel development GO:0001945 7 5 0,000 8,836E-03 0,10212325 ! endochondral ossification GO:0001958 12 5 0,000 8,836E-03 0,10161263 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 8,836E-03 0,1011071 ! parathyroid gland development GO:0060017 8 5 0,000 8,836E-03 0,10060657 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 8,836E-03 0,10011097 ! anagen GO:0042640 6 5 0,000 8,836E-03 0,09962023 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 8,836E-03 0,09913428 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 8,836E-03 0,09865304 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 8,836E-03 0,09817646 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 8,836E-03 0,09770446 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 8,836E-03 0,09723697 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 8,836E-03 0,09677394 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 8,836E-03 0,09631529 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 8,836E-03 0,09586098 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 8,836E-03 0,09541092 ! cardiac muscle fiber development GO:0048739 7 5 0,000 8,836E-03 0,09496508 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 8,836E-03 0,09452338 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 8,836E-03 0,09408577 ! neutrophil mediated immunity GO:0002446 6 5 0,000 8,836E-03 0,0936522 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 8,836E-03 0,0932226 ! ovulation GO:0030728 6 5 0,000 8,836E-03 0,09279693 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 8,836E-03 0,09237512 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 8,836E-03 0,09195714 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 8,836E-03 0,09154291 ! response to pH GO:0009268 9 5 0,000 8,836E-03 0,09113241 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 8,836E-03 0,09072557 ! proline biosynthetic process GO:0006561 6 5 0,000 8,836E-03 0,09032234 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 8,836E-03 0,08992269 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 8,836E-03 0,08952655 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 8,836E-03 0,08913389 ! polyol biosynthetic process GO:0046173 5 5 0,000 8,836E-03 0,08874466 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 8,836E-03 0,08835881 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 8,836E-03 0,08797631 ! sister chromatid cohesion GO:0007062 9 5 0,000 8,836E-03 0,0875971 ! nerve growth factor processing GO:0032455 7 5 0,000 8,836E-03 0,08722115 ! urea metabolic process GO:0019627 6 5 0,000 8,836E-03 0,08684841 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 8,836E-03 0,08647884 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 8,836E-03 0,0861124 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 8,836E-03 0,08574906 ! neutrophil activation GO:0042119 5 5 0,000 8,836E-03 0,08538877 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 8,836E-03 0,08503149 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 8,836E-03 0,0846772 ! response to food GO:0032094 5 5 0,000 8,836E-03 0,08432584 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 8,836E-03 0,08397738 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 8,836E-03 0,0836318 ! paraxial mesoderm development GO:0048339 9 5 0,000 8,836E-03 0,08328904 ! forebrain neuron development GO:0021884 7 5 0,000 8,836E-03 0,08294909 ! melanosome organization GO:0032438 7 5 0,000 8,836E-03 0,0826119 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 8,836E-03 0,08227744 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 8,836E-03 0,08194567 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 8,836E-03 0,08161657 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 8,836E-03 0,08129011 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 8,836E-03 0,08096624 ! nucleoside transport GO:0015858 6 5 0,000 8,836E-03 0,08064495 ! nucleoside salvage GO:0043174 7 5 0,000 8,836E-03 0,08032619 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 8,836E-03 0,08000995 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 8,836E-03 0,07969618 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 8,836E-03 0,07938487 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 8,836E-03 0,07907598 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 8,836E-03 0,07876948 ! early endosome to late endosome transport GO:0045022 11 5 0,000 8,836E-03 0,07846535 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 8,836E-03 0,07816356 ! depyrimidination GO:0045008 8 5 0,000 8,836E-03 0,07786409 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 8,836E-03 0,0775669 ! 5S class rRNA transcription GO:0042791 8 5 0,000 8,836E-03 0,07727197 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 8,836E-03 0,07697927 ! regulation of centrosome cycle GO:0046605 7 5 0,000 8,836E-03 0,07668878 ! neuronal ion channel clustering GO:0045161 7 5 0,000 8,836E-03 0,07640048 ! sodium ion homeostasis GO:0055078 6 5 0,000 8,836E-03 0,07611433 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 8,836E-03 0,07583032 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 8,836E-03 0,07554843 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 8,836E-03 0,07526862 ! monocyte differentiation GO:0030224 8 5 0,000 8,836E-03 0,07499087 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 8,836E-03 0,07471517 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 8,836E-03 0,07444149 ! centrosome duplication GO:0051298 5 5 0,000 8,836E-03 0,07416981 ! response to UV-C GO:0010225 6 5 0,000 8,836E-03 0,0739001 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 8,836E-03 0,07363234 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 8,836E-03 0,07336652 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 8,836E-03 0,07310261 ! regulation of dendrite development GO:0050773 12 5 0,000 8,836E-03 0,0728406 ! peptidyl-arginine modification GO:0018195 7 5 0,000 8,836E-03 0,07258045 ! positive regulation of organ growth GO:0046622 6 5 0,000 8,836E-03 0,07232216 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 8,836E-03 0,0720657 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 8,836E-03 0,07181105 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 8,836E-03 0,07155819 ! regulation of dopamine secretion GO:0014059 12 5 0,000 8,836E-03 0,07130711 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 8,836E-03 0,07105779 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 8,836E-03 0,0708102 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 8,836E-03 0,07056433 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 8,836E-03 0,07032016 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 8,836E-03 0,07007768 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 8,836E-03 0,06983686 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 8,836E-03 0,06959769 ! neural tube patterning GO:0021532 6 5 0,000 8,836E-03 0,06936016 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 8,836E-03 0,06912424 ! histone demethylation GO:0016577 9 5 0,000 8,836E-03 0,06888992 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 8,836E-03 0,06865719 ! regulation of sterol transport GO:0032371 7 5 0,000 8,836E-03 0,06842602 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 8,836E-03 0,0681964 ! enteric nervous system development GO:0048484 8 5 0,000 8,836E-03 0,06796832 ! establishment of planar polarity GO:0001736 6 5 0,000 8,836E-03 0,06774176 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 8,836E-03 0,0675167 ! muscle cell proliferation GO:0033002 8 5 0,000 8,836E-03 0,06729314 ! transcription termination GO:0006353 8 5 0,000 8,836E-03 0,06707105 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 8,836E-03 0,06685042 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 8,836E-03 0,06663124 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 8,836E-03 0,06641349 ! regulation of respiratory burst GO:0060263 8 5 0,000 8,836E-03 0,06619716 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 8,836E-03 0,06598223 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 8,836E-03 0,0657687 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 8,836E-03 0,06555654 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 8,836E-03 0,06534575 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 8,836E-03 0,0651363 ! apical protein localization GO:0045176 6 5 0,000 8,836E-03 0,0649282 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 8,836E-03 0,06472142 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 8,836E-03 0,06451596 ! galactolipid metabolic process GO:0019374 7 5 0,000 8,836E-03 0,06431179 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 8,836E-03 0,06410892 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 8,836E-03 0,06390732 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 8,836E-03 0,06370698 ! triglyceride catabolic process GO:0019433 6 5 0,000 8,836E-03 0,0635079 ! glial cell migration GO:0008347 10 5 0,000 8,836E-03 0,06331005 ! determination of adult lifespan GO:0008340 8 5 0,000 8,836E-03 0,06311344 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 8,836E-03 0,06291804 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 8,836E-03 0,06272385 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 8,836E-03 0,06253085 ! somatic stem cell maintenance GO:0035019 13 5 0,000 8,836E-03 0,06233904 ! cerebellar cortex formation GO:0021697 6 5 0,000 8,836E-03 0,0621484 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 8,836E-03 0,06195892 ! regulation of sensory perception GO:0051931 6 5 0,000 8,836E-03 0,0617706 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 8,836E-03 0,06158341 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 8,836E-03 0,06139736 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 8,836E-03 0,06121243 ! sensory cilium assembly GO:0035058 6 5 0,000 8,836E-03 0,06102861 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 8,836E-03 0,06084589 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 8,836E-03 0,06066426 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 8,836E-03 0,06048371 ! spindle assembly GO:0051225 5 5 0,000 8,836E-03 0,06030423 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 8,836E-03 0,06012582 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 8,836E-03 0,05994846 ! protein amino acid prenylation GO:0018346 9 5 0,000 8,836E-03 0,05977214 ! organ regeneration GO:0031100 7 5 0,000 8,836E-03 0,05959685 ! NAD biosynthetic process GO:0009435 7 5 0,000 8,836E-03 0,05942259 ! carnitine metabolic process GO:0009437 5 5 0,000 8,836E-03 0,05924935 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 8,836E-03 0,05907711 ! cellular anion homeostasis GO:0030002 6 5 0,000 8,836E-03 0,05890587 GO:0055081|anion homeostasis, ! hemostasis GO:0007599 125 81 1,000 9,037E-03 0,06007558 ! regulation of cell cycle process GO:0010564 122 81 1,000 9,037E-03 0,05990245 ! regulation of neurological system process GO:0031644 122 81 1,000 9,037E-03 0,05973032 ! regulation of cell adhesion GO:0030155 159 83 1,000 9,471E-03 0,06241829 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 9,692E-03 0,06368804 ! regulation of membrane potential GO:0042391 128 85 1,000 9,914E-03 0,06496551 ! cell cycle arrest GO:0007050 150 86 1,000 0,01013922 0,0662506 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,01013922 0,06606292 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,01036641 0,06735237 GO:0060538|skeletal muscle organ development, ! tRNA transcription GO:0009304 11 6 0,000 0,01059397 0,06863698 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01059397 0,06844418 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01059397 0,06825246 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01059397 0,06806181 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01059397 0,06787222 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01059397 0,06768369 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01059397 0,0674962 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01059397 0,06730974 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01059397 0,06712432 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01059397 0,06693991 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01059397 0,06675651 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01059397 0,06657412 ! prostate gland development GO:0030850 9 6 0,000 0,01059397 0,06639272 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01059397 0,0662123 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01059397 0,06603286 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01059397 0,0658544 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01059397 0,06567689 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01059397 0,06550034 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01059397 0,06532474 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01059397 0,06515007 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01059397 0,06497634 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01059397 0,06480353 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01059397 0,06463164 ! neuron adhesion GO:0007158 9 6 0,000 0,01059397 0,06446065 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01059397 0,06429057 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01059397 0,06412139 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01059397 0,06395309 ! signal peptide processing GO:0006465 8 6 0,000 0,01059397 0,06378567 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01059397 0,06361913 ! mRNA stabilization GO:0048255 15 6 0,000 0,01059397 0,06345346 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01059397 0,06328864 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01059397 0,06312468 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01059397 0,06296157 ! opsonization GO:0008228 8 6 0,000 0,01059397 0,0627993 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01059397 0,06263786 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01059397 0,06247725 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01059397 0,06231746 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01059397 0,06215849 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01059397 0,06200032 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01059397 0,06184296 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01059397 0,0616864 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01059397 0,06153062 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01059397 0,06137563 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01059397 0,06122142 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01059397 0,06106799 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01059397 0,06091532 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01059397 0,06076341 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01059397 0,06061226 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01059397 0,06046185 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01059397 0,0603122 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01059397 0,06016328 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01059397 0,06001509 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01059397 0,05986763 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01059397 0,0597209 ! thymic T cell selection GO:0045061 12 6 0,000 0,01059397 0,05957488 ! protein lipoylation GO:0009249 10 6 0,000 0,01059397 0,05942958 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01059397 0,05928498 ! pigment granule organization GO:0048753 11 6 0,000 0,01059397 0,05914109 ! drug transport GO:0015893 6 6 0,000 0,01059397 0,05899789 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01059397 0,05885538 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01059397 0,05871356 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01059397 0,05857242 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01059397 0,05843196 ! histidine metabolic process GO:0006547 6 6 0,000 0,01059397 0,05829217 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01059397 0,05815305 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01059397 0,05801459 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01059397 0,05787679 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01059397 0,05773964 ! adenohypophysis development GO:0021984 10 6 0,000 0,01059397 0,05760314 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01059397 0,05746728 ! hyperosmotic response GO:0006972 8 6 0,000 0,01059397 0,05733206 ! microtubule nucleation GO:0007020 10 6 0,000 0,01059397 0,05719748 ! ER overload response GO:0006983 7 6 0,000 0,01059397 0,05706353 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01059397 0,0569302 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01059397 0,0567975 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01059397 0,05666541 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01059397 0,05653394 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01059397 0,05640307 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01059397 0,05627281 ! response to dietary excess GO:0002021 7 6 0,000 0,01059397 0,05614315 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01059397 0,05601409 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01059397 0,05588561 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01059397 0,05575773 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01059397 0,05563043 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01059397 0,05550371 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01059397 0,05537756 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01059397 0,05525199 ! neuron apoptosis GO:0051402 8 6 0,000 0,01059397 0,05512698 ! organic alcohol transport GO:0015850 9 6 0,000 0,01059397 0,05500254 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01059397 0,05487866 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01059397 0,05475534 ! male sex determination GO:0030238 9 6 0,000 0,01059397 0,05463257 ! carnitine transport GO:0015879 8 6 0,000 0,01059397 0,05451035 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01059397 0,05438868 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01059397 0,05426754 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01059397 0,05414695 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01059397 0,05402689 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01059397 0,05390736 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01059397 0,05378836 ! parturition GO:0007567 12 6 0,000 0,01059397 0,05366988 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01059397 0,05355193 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01059397 0,05343449 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01059397 0,05331756 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01059397 0,05320115 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01059397 0,05308524 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01059397 0,05296984 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01059397 0,05285494 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01059397 0,05274053 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01059397 0,05262662 ! macrophage differentiation GO:0030225 10 6 0,000 0,01059397 0,0525132 ! astrocyte development GO:0014002 14 6 0,000 0,01059397 0,05240027 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01059397 0,05228783 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01059397 0,05217586 ! interaction with symbiont GO:0051702 8 6 0,000 0,01059397 0,05206437 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01059397 0,05195336 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01059397 0,05184282 ! eating behavior GO:0042755 6 6 0,000 0,01059397 0,05173275 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01059397 0,05162315 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01059397 0,05151401 ! response to copper ion GO:0046688 9 6 0,000 0,01059397 0,05140533 ! DNA topological change GO:0006265 8 6 0,000 0,01059397 0,05129711 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01059397 0,05118934 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01059397 0,05108203 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01059397 0,05097516 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01059397 0,05086874 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01059397 0,05076276 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01059397 0,05065723 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01059397 0,05055213 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01059397 0,05044747 ! gas homeostasis GO:0033483 11 6 0,000 0,01059397 0,05034324 ! hair follicle maturation GO:0048820 7 6 0,000 0,01059397 0,05023944 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01059397 0,05013606 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01059397 0,05003312 ! Schwann cell development GO:0014044 14 6 0,000 0,01059397 0,04993059 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01059397 0,04982848 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01059397 0,04972679 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01059397 0,04962551 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01059397 0,04952465 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01059397 0,04942419 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01059397 0,04932414 ! histone ubiquitination GO:0016574 7 6 0,000 0,01059397 0,0492245 ! regulation of meiosis GO:0040020 10 6 0,000 0,01059397 0,04912526 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01059397 0,04902641 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01059397 0,04892797 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01059397 0,04882991 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01059397 0,04873225 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01059397 0,04863498 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01059397 0,0485381 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01059397 0,0484416 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01059397 0,04834549 ! receptor internalization GO:0031623 9 6 0,000 0,01059397 0,04824976 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01059397 0,0481544 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01059397 0,04805942 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01059397 0,04796482 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01059397 0,04787058 ! protein deubiquitination GO:0016579 8 6 0,000 0,01059397 0,04777672 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01059397 0,04768322 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01059397 0,04759009 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01059397 0,04749732 ! axonal fasciculation GO:0007413 9 6 0,000 0,01059397 0,04740492 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01059397 0,04731287 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01059397 0,04722118 ! midbrain development GO:0030901 6 6 0,000 0,01059397 0,04712984 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01059397 0,04703886 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01059397 0,04694822 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01059397 0,04685794 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01059397 0,046768 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01059397 0,0466784 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01059397 0,04658915 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01059397 0,04650024 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01059397 0,04641167 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01059397 0,04632344 ! adult feeding behavior GO:0008343 6 6 0,000 0,01059397 0,04623554 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01059397 0,04614797 ! blastocyst growth GO:0001832 15 6 0,000 0,01059397 0,04606073 ! pigment granule transport GO:0051904 12 6 0,000 0,01059397 0,04597382 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01059397 0,04588724 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01059397 0,04580099 ! catecholamine transport GO:0051937 7 6 0,000 0,01059397 0,04571506 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01059397 0,04562945 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01059397 0,04554416 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01059397 0,04545919 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01059397 0,04537454 ! protein prenylation GO:0018342 10 6 0,000 0,01059397 0,0452902 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01059397 0,04520617 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01059397 0,04512246 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,01059397 0,04503905 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,01059397 0,04495595 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01059397 0,04487316 ! interphase GO:0051325 159 88 1,000 0,01059585 0,04479864 ! establishment of RNA localization GO:0051236 128 88 1,000 0,01059585 0,04471644 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! RNA localization GO:0006403 135 91 1,000 0,01129766 0,04759086 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01234904 0,05192465 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01234904 0,0518299 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01234904 0,05173549 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01234904 0,05164143 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01234904 0,05154771 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01234904 0,05145432 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01234904 0,05136128 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01234904 0,05126857 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01234904 0,05117619 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01234904 0,05108415 ! reproductive behavior GO:0019098 12 7 0,000 0,01234904 0,05099243 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01234904 0,05090105 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,01234904 0,05080999 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01234904 0,05071926 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,01234904 0,05062885 ! oligopeptide transport GO:0006857 11 7 0,000 0,01234904 0,05053877 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01234904 0,050449 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01234904 0,05035955 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,01234904 0,05027042 ! RNA methylation GO:0001510 11 7 0,000 0,01234904 0,0501816 ! pericardium development GO:0060039 8 7 0,000 0,01234904 0,0500931 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01234904 0,0500049 ! fibril organization GO:0043206 13 7 0,000 0,01234904 0,04991702 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01234904 0,04982945 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01234904 0,04974218 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01234904 0,04965522 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01234904 0,04956856 ! lipoprotein transport GO:0042953 9 7 0,000 0,01234904 0,04948221 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01234904 0,04939615 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01234904 0,04931039 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01234904 0,04922493 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01234904 0,04913977 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01234904 0,0490549 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01234904 0,04897032 ! chemosensory behavior GO:0007635 9 7 0,000 0,01234904 0,04888603 ! microtubule bundle formation GO:0001578 8 7 0,000 0,01234904 0,04880204 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,01234904 0,04871833 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01234904 0,04863491 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01234904 0,04855177 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01234904 0,04846892 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01234904 0,04838635 ! reflex GO:0060004 12 7 0,000 0,01234904 0,04830406 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01234904 0,04822205 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01234904 0,04814032 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01234904 0,04805886 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01234904 0,04797768 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01234904 0,04789677 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01234904 0,04781614 ! spinal cord patterning GO:0021511 7 7 0,000 0,01234904 0,04773577 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01234904 0,04765568 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,01234904 0,04757586 ! adrenal gland development GO:0030325 17 7 0,000 0,01234904 0,0474963 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01234904 0,047417 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01234904 0,04733798 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01234904 0,04725921 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01234904 0,04718071 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01234904 0,04710246 ! endosome organization GO:0007032 10 7 0,000 0,01234904 0,04702448 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01234904 0,04694675 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,01234904 0,04686928 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01234904 0,04679207 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01234904 0,04671511 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01234904 0,0466384 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01234904 0,04656194 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01234904 0,04648574 ! galactose metabolic process GO:0006012 10 7 0,000 0,01234904 0,04640978 ! vesicle fusion GO:0006906 15 7 0,000 0,01234904 0,04633407 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01234904 0,04625861 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01234904 0,04618339 ! organ growth GO:0035265 11 7 0,000 0,01234904 0,04610842 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,01234904 0,04603369 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01234904 0,0459592 ! retinol metabolic process GO:0042572 9 7 0,000 0,01234904 0,04588495 ! behavioral fear response GO:0001662 13 7 0,000 0,01234904 0,04581095 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,01234904 0,04573718 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01234904 0,04566364 ! rRNA modification GO:0000154 12 7 0,000 0,01234904 0,04559035 ! protein heterooligomerization GO:0051291 10 7 0,000 0,01234904 0,04551729 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01234904 0,04544446 ! response to UV-B GO:0010224 11 7 0,000 0,01234904 0,04537186 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01234904 0,0452995 ! intermediate filament organization GO:0045109 11 7 0,000 0,01234904 0,04522737 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,01234904 0,04515546 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01234904 0,04508379 ! fibrinolysis GO:0042730 9 7 0,000 0,01234904 0,04501234 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01234904 0,04494112 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01234904 0,04487012 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01234904 0,04479935 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01234904 0,0447288 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01234904 0,04465847 ! response to tropane GO:0014073 13 7 0,000 0,01234904 0,04458836 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01234904 0,04451847 ! melanosome localization GO:0032400 10 7 0,000 0,01234904 0,0444488 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01234904 0,04437935 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01234904 0,04431012 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,01234904 0,0442411 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01234904 0,0441723 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01234904 0,0441037 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01234904 0,04403533 ! mast cell activation GO:0045576 9 7 0,000 0,01234904 0,04396716 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01234904 0,04389921 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01234904 0,04383146 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01234904 0,04376392 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01234904 0,04369659 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01234904 0,04362947 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,01234904 0,04356256 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01234904 0,04349584 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01234904 0,04342934 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,01234904 0,04336303 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01234904 0,04329693 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01234904 0,04323103 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01234904 0,04316533 ! response to tumor cell GO:0002347 12 7 0,000 0,01234904 0,04309983 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01234904 0,04303452 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01234904 0,04296942 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01234904 0,04290451 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,01234904 0,0428398 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01234904 0,04277528 ! diuresis GO:0030146 12 7 0,000 0,01234904 0,04271096 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01234904 0,04264683 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01234904 0,04258289 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01234904 0,04251914 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01234904 0,04245558 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01234904 0,04239222 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01234904 0,04232904 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01234904 0,04226605 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01234904 0,04220325 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01234904 0,04214063 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01234904 0,0420782 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01234904 0,04201596 ! lymph node development GO:0048535 9 7 0,000 0,01234904 0,04195389 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01234904 0,04189201 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01234904 0,04183032 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01234904 0,0417688 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,01234904 0,04170747 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,01234904 0,04164631 ! ATP catabolic process GO:0006200 10 7 0,000 0,01234904 0,04158534 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01234904 0,04152454 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01234904 0,04146392 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,01234904 0,04140348 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01234904 0,04134321 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01234904 0,04128312 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01234904 0,0412232 ! muscle adaptation GO:0043500 12 7 0,000 0,01234904 0,04116346 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01234904 0,04110389 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01234904 0,04104449 ! retina homeostasis GO:0001895 9 7 0,000 0,01234904 0,04098526 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01234904 0,0409262 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,01234904 0,04086732 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01234904 0,0408086 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,01234904 0,04075005 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01234904 0,04069167 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01234904 0,04063346 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01234904 0,04057541 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,01251174 0,04105136 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,01251174 0,04099288 ! response to light stimulus GO:0009416 153 96 1,000 0,01251174 0,04093457 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,01326648 0,0433422 ! regulation of translation GO:0006417 151 100 1,000 0,0135224 0,04411562 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,0135224 0,04405313 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,0135224 0,04399082 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,01410109 0,04580864 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,01410109 0,04574403 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,01410109 0,0456796 ! axon extension GO:0048675 11 8 0,000 0,01410109 0,04561535 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,01410109 0,04555128 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,01410109 0,0454874 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,01410109 0,04542369 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,01410109 0,04536016 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,01410109 0,04529681 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,01410109 0,04523363 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,01410109 0,04517063 ! phosphate transport GO:0006817 10 8 0,000 0,01410109 0,04510781 ! N-glycan processing GO:0006491 12 8 0,000 0,01410109 0,04504516 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,01410109 0,04498268 ! UTP metabolic process GO:0046051 8 8 0,000 0,01410109 0,04492038 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,01410109 0,04485825 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,01410109 0,04479629 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,01410109 0,0447345 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,01410109 0,04467289 ! succinate metabolic process GO:0006105 14 8 0,000 0,01410109 0,04461144 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,01410109 0,04455016 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,01410109 0,04448905 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,01410109 0,0444281 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,01410109 0,04436733 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,01410109 0,04430671 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,01410109 0,04424627 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,01410109 0,04418599 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,01410109 0,04412587 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01410109 0,04406592 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,01410109 0,04400613 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,01410109 0,0439465 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,01410109 0,04388703 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,01410109 0,04382772 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,01410109 0,04376858 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,01410109 0,04370959 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,01410109 0,04365076 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,01410109 0,04359209 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,01410109 0,04353358 ! astrocyte differentiation GO:0048708 16 8 0,000 0,01410109 0,04347522 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,01410109 0,04341702 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,01410109 0,04335898 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,01410109 0,04330109 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,01410109 0,04324335 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,01410109 0,04318577 ! melanin metabolic process GO:0006582 12 8 0,000 0,01410109 0,04312834 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,01410109 0,04307107 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,01410109 0,04301395 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,01410109 0,04295697 ! macrophage activation GO:0042116 12 8 0,000 0,01410109 0,04290015 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,01410109 0,04284348 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,01410109 0,04278696 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,01410109 0,04273059 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,01410109 0,04267436 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01410109 0,04261829 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,01410109 0,04256236 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,01410109 0,04250657 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,01410109 0,04245094 ! ruffle organization GO:0031529 11 8 0,000 0,01410109 0,04239544 ! osteoblast development GO:0002076 13 8 0,000 0,01410109 0,0423401 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,01410109 0,0422849 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,01410109 0,04222984 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,01410109 0,04217492 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,01410109 0,04212015 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,01410109 0,04206552 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,01410109 0,04201103 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,01410109 0,04195668 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,01410109 0,04190247 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,01410109 0,04184841 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,01410109 0,04179448 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,01410109 0,04174069 ! oligodendrocyte development GO:0014003 8 8 0,000 0,01410109 0,04168704 ! segment specification GO:0007379 10 8 0,000 0,01410109 0,04163352 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,01410109 0,04158015 ! cellular extravasation GO:0045123 11 8 0,000 0,01410109 0,04152691 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,01410109 0,0414738 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,01410109 0,04142084 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,01410109 0,041368 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,01410109 0,04131531 ! snRNA metabolic process GO:0016073 10 8 0,000 0,01410109 0,04126274 GO:0016180|snRNA processing, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 0,000 0,01410109 0,04121031 ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,01410109 0,04115801 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,01410109 0,04110585 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,01410109 0,04105382 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,01410109 0,04100192 ! nucleosome disassembly GO:0006337 12 8 0,000 0,01410109 0,04095015 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,01410109 0,04089851 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,01410109 0,040847 ! icosanoid secretion GO:0032309 12 8 0,000 0,01410109 0,04079562 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,01410109 0,04074437 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,01410109 0,04069324 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,01410109 0,04064225 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,01410109 0,04059138 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,01410109 0,04054064 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,01410109 0,04049003 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,01410109 0,04043954 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,01410109 0,04038918 ! sterol catabolic process GO:0016127 9 8 0,000 0,01410109 0,04033895 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,01410109 0,04028884 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,01410109 0,04023885 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,01410109 0,04018899 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,01410109 0,04013925 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,01410109 0,04008964 ! prophase GO:0051324 11 8 0,000 0,01410109 0,04004014 ! S phase GO:0051320 8 8 0,000 0,01410109 0,03999077 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,01410109 0,03994152 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,01410109 0,03989239 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,01410109 0,03984338 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,01410109 0,0397945 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,01410109 0,03974573 ! hormone catabolic process GO:0042447 13 8 0,000 0,01410109 0,03969708 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,01410109 0,03964855 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,01410109 0,03960014 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,01410109 0,03955185 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,01410109 0,03950367 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,01410109 0,03945561 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,01410109 0,03940767 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,01410109 0,03935985 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,01410109 0,03931214 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,01410109 0,03926455 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,01410109 0,03921707 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,01410109 0,0391697 ! lamellipodium assembly GO:0030032 9 8 0,000 0,01410109 0,03912245 ! regulation of embryonic development GO:0045995 16 8 0,000 0,01410109 0,03907532 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,01410109 0,0390283 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,01410109 0,03898139 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,01410109 0,03893459 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,01585014 0,04371142 ! regulation of developmental growth GO:0048638 13 9 0,000 0,01585014 0,04365907 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,01585014 0,04360685 ! telencephalon cell migration GO:0022029 16 9 0,000 0,01585014 0,04355475 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,01585014 0,04350278 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,01585014 0,04345092 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,01585014 0,0433992 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,01585014 0,04334759 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,01585014 0,04329611 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,01585014 0,04324475 ! GTP metabolic process GO:0046039 9 9 0,000 0,01585014 0,04319351 ! elastic fiber assembly GO:0048251 13 9 0,000 0,01585014 0,0431424 ! social behavior GO:0035176 14 9 0,000 0,01585014 0,0430914 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,01585014 0,04304053 ! artery development GO:0060840 19 9 0,000 0,01585014 0,04298977 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,01585014 0,04293913 ! regulation of glycolysis GO:0006110 15 9 0,000 0,01585014 0,04288862 ! response to pain GO:0048265 16 9 0,000 0,01585014 0,04283822 ! protein complex disassembly GO:0043241 17 9 0,000 0,01585014 0,04278794 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,01585014 0,04273778 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,01585014 0,04268773 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,01585014 0,04263781 ! lung alveolus development GO:0048286 17 9 0,000 0,01585014 0,042588 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,01585014 0,0425383 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,01585014 0,04248872 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,01585014 0,04243926 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,01585014 0,04238991 ! ventral spinal cord development GO:0021517 11 9 0,000 0,01585014 0,04234068 ! protein targeting to ER GO:0045047 19 9 0,000 0,01585014 0,04229156 ! T cell selection GO:0045058 18 9 0,000 0,01585014 0,04224256 ! endoderm development GO:0007492 12 9 0,000 0,01585014 0,04219366 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,01585014 0,04214488 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,01585014 0,04209622 ! arginine catabolic process GO:0006527 10 9 0,000 0,01585014 0,04204766 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,01585014 0,04199922 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,01585014 0,04195089 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,01585014 0,04190267 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,01585014 0,04185456 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,01585014 0,04180657 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,01585014 0,04175868 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,01585014 0,0417109 ! mannose metabolic process GO:0006013 9 9 0,000 0,01585014 0,04166323 ! epithelial cell development GO:0002064 10 9 0,000 0,01585014 0,04161567 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,01585014 0,04156822 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,01585014 0,04152087 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,01585014 0,04147364 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,01585014 0,04142651 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,01585014 0,04137948 ! motor axon guidance GO:0008045 14 9 0,000 0,01585014 0,04133257 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,01585014 0,04128576 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,01585014 0,04123906 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,01585014 0,04119246 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,01585014 0,04114597 ! blastoderm segmentation GO:0007350 11 9 0,000 0,01585014 0,04109958 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,01585014 0,04105329 ! DNA ligation GO:0006266 14 9 0,000 0,01585014 0,04100712 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,01585014 0,04096104 ! response to amine stimulus GO:0014075 13 9 0,000 0,01585014 0,04091507 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,01585014 0,0408692 ! erythrocyte development GO:0048821 11 9 0,000 0,01585014 0,04082343 ! renal water homeostasis GO:0003091 14 9 0,000 0,01585014 0,04077777 ! postreplication repair GO:0006301 11 9 0,000 0,01585014 0,04073221 ! mRNA cleavage GO:0006379 13 9 0,000 0,01585014 0,04068675 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,01585014 0,04064139 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,01585014 0,04059613 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,01585014 0,04055097 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,01585014 0,04050592 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,01585014 0,04046096 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,01585014 0,0404161 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,01585014 0,04037135 ! acid secretion GO:0046717 14 9 0,000 0,01585014 0,04032669 ! musculoskeletal movement GO:0050881 11 9 0,000 0,01585014 0,04028213 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,01585014 0,04023767 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,01585014 0,0401933 ! purine base metabolic process GO:0006144 18 9 0,000 0,01585014 0,04014904 ! oocyte differentiation GO:0009994 12 9 0,000 0,01585014 0,04010487 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,01585014 0,0400608 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,01585014 0,04001682 ! spleen development GO:0048536 15 9 0,000 0,01585014 0,03997294 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,01585014 0,03992916 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,01585014 0,03988548 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,01585014 0,03984189 ! detection of calcium ion GO:0005513 13 9 0,000 0,01585014 0,03979839 ! blastocyst formation GO:0001825 12 9 0,000 0,01585014 0,03975499 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,01585014 0,03971168 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,01585014 0,03966847 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,01585014 0,03962535 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,01585014 0,03958233 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,01585014 0,0395394 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,01585014 0,03949656 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,01585014 0,03945382 ! prepulse inhibition GO:0060134 14 9 0,000 0,01585014 0,03941116 ! embryonic placenta development GO:0001892 12 9 0,000 0,01585014 0,0393686 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,01585014 0,03932613 ! insulin secretion GO:0030073 17 9 0,000 0,01585014 0,03928376 ! sequestering of metal ion GO:0051238 11 9 0,000 0,01585014 0,03924147 ! response to nicotine GO:0035094 16 9 0,000 0,01585014 0,03919927 ! nucleus localization GO:0051647 15 9 0,000 0,01585014 0,03915717 ! regulation of synapse organization GO:0050807 12 9 0,000 0,01585014 0,03911516 ! localization within membrane GO:0051668 15 9 0,000 0,01585014 0,03907323 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,01759619 0,04333108 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,01759619 0,04328474 ! neuron fate specification GO:0048665 11 10 0,000 0,01759619 0,04323849 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,01759619 0,04319235 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,01759619 0,0431463 ! thyroid gland development GO:0030878 19 10 0,000 0,01759619 0,04310035 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,01759619 0,0430545 ! synapsis GO:0007129 13 10 0,000 0,01759619 0,04300875 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,01759619 0,04296309 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,01759619 0,04291753 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,01759619 0,04287206 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,01759619 0,0428267 ! sulfate transport GO:0008272 12 10 0,000 0,01759619 0,04278143 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,01759619 0,04273625 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,01759619 0,04269117 ! androgen metabolic process GO:0008209 13 10 0,000 0,01759619 0,04264618 ! phospholipid efflux GO:0033700 16 10 0,000 0,01759619 0,04260129 ! hippocampus development GO:0021766 19 10 0,000 0,01759619 0,0425565 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,01759619 0,0425118 ! blood vessel remodeling GO:0001974 21 10 0,000 0,01759619 0,04246719 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,01759619 0,04242267 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,01759619 0,04237825 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,01759619 0,04233392 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,01759619 0,04228969 ! pathogenesis GO:0009405 13 10 0,000 0,01759619 0,04224554 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,01759619 0,04220149 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,01759619 0,04215753 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,01759619 0,04211366 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,01759619 0,04206988 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,01759619 0,0420262 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,01759619 0,0419826 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,01759619 0,0419391 ! melanocyte differentiation GO:0030318 15 10 0,000 0,01759619 0,04189568 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,01759619 0,04185236 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,01759619 0,04180912 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,01759619 0,04176597 ! response to X-ray GO:0010165 16 10 0,000 0,01759619 0,04172292 ! B cell proliferation GO:0042100 14 10 0,000 0,01759619 0,04167995 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,01759619 0,04163707 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,01759619 0,04159427 ! forebrain cell migration GO:0021885 17 10 0,000 0,01759619 0,04155157 ! lipid digestion GO:0044241 15 10 0,000 0,01759619 0,04150895 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,01759619 0,04146642 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,01759619 0,04142398 ! UV protection GO:0009650 14 10 0,000 0,01759619 0,04138162 ! entry into host cell GO:0030260 20 10 0,000 0,01759619 0,04133936 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,01759619 0,04129717 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,01759619 0,04125508 ! negative regulation of ossification GO:0030279 19 10 0,000 0,01759619 0,04121306 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,01759619 0,04117114 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,01759619 0,0411293 ! regulation of bone resorption GO:0045124 24 10 0,000 0,01759619 0,04108754 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,01759619 0,04104587 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,01759619 0,04100428 ! regulation of organ growth GO:0046620 11 10 0,000 0,01759619 0,04096278 ! response to dsRNA GO:0043331 18 10 0,000 0,01759619 0,04092136 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,01759619 0,04088003 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,01759619 0,04083878 ! embryonic axis specification GO:0000578 12 10 0,000 0,01759619 0,04079761 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,01759619 0,04075652 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,01759619 0,04071552 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,01759619 0,0406746 ! cranial nerve development GO:0021545 12 10 0,000 0,01759619 0,04063376 ! fucose catabolic process GO:0019317 16 10 0,000 0,01759619 0,04059301 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,01759619 0,04055233 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,01759619 0,04051174 ! protein sumoylation GO:0016925 12 10 0,000 0,01759619 0,04047123 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,01759619 0,0404308 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,01759619 0,04039045 ! zymogen activation GO:0031638 14 10 0,000 0,01759619 0,04035018 ! salivary gland development GO:0007431 22 10 0,000 0,01759619 0,04030999 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,01759619 0,04026988 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,01759619 0,04022985 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,01759619 0,0401899 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,01759619 0,04015003 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,01759619 0,04011024 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,01759619 0,04007052 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,01759619 0,04003089 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,01759619 0,03999133 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,01759619 0,03995186 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,01759619 0,03991245 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,01759619 0,03987313 ! detection of bacterium GO:0016045 10 10 0,000 0,01759619 0,03983389 ! embryonic gut development GO:0048566 11 10 0,000 0,01759619 0,03979472 ! activation of innate immune response GO:0002218 10 10 0,000 0,01759619 0,03975563 GO:0002758|innate immune response-activating signal transduction, ! cardiac cell differentiation GO:0035051 16 10 0,000 0,01759619 0,03971661 ! developmental induction GO:0031128 13 10 0,000 0,01759619 0,03967768 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,01759619 0,03963881 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,01759619 0,03960003 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,01759619 0,03956132 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,01759619 0,03952268 ! rRNA transcription GO:0009303 17 11 0,000 0,01933923 0,04339535 ! respiratory burst GO:0045730 14 11 0,000 0,01933923 0,04335306 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,01933923 0,04331084 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,01933923 0,04326871 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,01933923 0,04322666 ! virus-host interaction GO:0019048 17 11 0,000 0,01933923 0,0431847 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,01933923 0,04314281 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,01933923 0,04310101 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,01933923 0,04305928 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,01933923 0,04301764 ! RNA polyadenylation GO:0043631 19 11 0,000 0,01933923 0,04297607 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,01933923 0,04293459 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,01933923 0,04289319 ! mating GO:0007618 14 11 0,000 0,01933923 0,04285187 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,01933923 0,04281062 ! T cell proliferation GO:0042098 20 11 0,000 0,01933923 0,04276946 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,01933923 0,04272837 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,01933923 0,04268737 ! bone resorption GO:0045453 16 11 0,000 0,01933923 0,04264644 ! regulated secretory pathway GO:0045055 14 11 0,000 0,01933923 0,04260559 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,01933923 0,04256482 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,01933923 0,04252413 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,01933923 0,04248351 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,01933923 0,04244297 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,01933923 0,04240251 ! syncytium formation GO:0006949 15 11 0,000 0,01933923 0,04236213 ! plasma membrane organization GO:0007009 18 11 0,000 0,01933923 0,04232182 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,01933923 0,04228159 ! focal adhesion formation GO:0048041 24 11 0,000 0,01933923 0,04224144 ! mitotic spindle organization GO:0007052 15 11 0,000 0,01933923 0,04220136 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,01933923 0,04216136 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,01933923 0,04212144 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,01933923 0,04208159 ! adult heart development GO:0007512 11 11 0,000 0,01933923 0,04204181 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,01933923 0,04200211 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,01933923 0,04196249 ! temperature homeostasis GO:0001659 16 11 0,000 0,01933923 0,04192294 ! L-glutamate transport GO:0015813 16 11 0,000 0,01933923 0,04188346 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,01933923 0,04184406 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,01933923 0,04180473 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,01933923 0,04176548 ! stem cell development GO:0048864 29 11 0,000 0,01933923 0,0417263 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,01933923 0,0416872 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,01933923 0,04164816 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,01933923 0,0416092 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,01933923 0,04157032 ! vasoconstriction GO:0042310 15 11 0,000 0,01933923 0,0415315 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,01933923 0,04149276 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,01933923 0,04145409 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,01933923 0,04141549 ! ribosome assembly GO:0042255 13 11 0,000 0,01933923 0,04137697 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,01933923 0,04133851 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,01933923 0,04130013 ! chromatin silencing GO:0006342 19 11 0,000 0,01933923 0,04126182 ! nucleosome positioning GO:0016584 13 11 0,000 0,01933923 0,04122357 ! T cell homeostasis GO:0043029 20 11 0,000 0,01933923 0,0411854 ! regulation of isotype switching GO:0045191 19 11 0,000 0,01933923 0,04114731 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,01933923 0,04110928 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,01933923 0,04107132 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,01933923 0,04103343 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,01933923 0,04099561 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,01933923 0,04095786 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,01933923 0,04092018 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,01933923 0,04088257 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,01933923 0,04084503 ! male genitalia development GO:0030539 13 11 0,000 0,01933923 0,04080756 ! cholesterol efflux GO:0033344 19 11 0,000 0,01933923 0,04077015 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,01933923 0,04073282 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,01933923 0,04069555 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,01933923 0,04065835 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,01933923 0,04062122 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,01933923 0,04058416 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,01933923 0,04054716 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,01933923 0,04051023 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,01933923 0,04047337 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,01933923 0,04043658 ! lysogeny GO:0030069 18 11 0,000 0,01933923 0,04039985 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,01933923 0,04036319 ! acrosome reaction GO:0007340 13 11 0,000 0,01933923 0,0403266 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,01933923 0,04029007 ! lactation GO:0007595 20 12 0,000 0,02107929 0,04387544 ! reproductive cellular process GO:0048610 14 12 0,000 0,02107929 0,04383577 ! tRNA modification GO:0006400 14 12 0,000 0,02107929 0,04379617 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,02107929 0,04375664 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,02107929 0,04371719 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,02107929 0,0436778 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,02107929 0,04363849 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,02107929 0,04359925 ! non-recombinational repair GO:0000726 19 12 0,000 0,02107929 0,04356007 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,02107929 0,04352097 ! peroxisomal transport GO:0043574 21 12 0,000 0,02107929 0,04348194 ! cartilage condensation GO:0001502 18 12 0,000 0,02107929 0,04344298 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,02107929 0,04340408 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,02107929 0,04336526 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,02107929 0,04332651 ! heart looping GO:0001947 15 12 0,000 0,02107929 0,04328782 ! palate development GO:0060021 15 12 0,000 0,02107929 0,04324921 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,02107929 0,04321066 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,02107929 0,04317218 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,02107929 0,04313377 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,02107929 0,04309543 ! arginine metabolic process GO:0006525 13 12 0,000 0,02107929 0,04305716 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,02107929 0,04301895 ! methionine metabolic process GO:0006555 13 12 0,000 0,02107929 0,04298082 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,02107929 0,04294275 ! Golgi organization GO:0007030 18 12 0,000 0,02107929 0,04290474 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,02107929 0,04286681 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,02107929 0,04282894 ! monoamine transport GO:0015844 13 12 0,000 0,02107929 0,04279114 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02107929 0,04275341 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,02107929 0,04271574 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,02107929 0,04267814 ! L-amino acid transport GO:0015807 20 12 0,000 0,02107929 0,0426406 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,02107929 0,04260313 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,02107929 0,04256573 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,02107929 0,04252839 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,02107929 0,04249111 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,02107929 0,04245391 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,02107929 0,04241676 ! cerebellum development GO:0021549 13 12 0,000 0,02107929 0,04237969 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,02107929 0,04234267 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,02107929 0,04230573 ! histone acetylation GO:0016573 23 12 0,000 0,02107929 0,04226884 ! histone methylation GO:0016571 15 12 0,000 0,02107929 0,04223202 ! autonomic nervous system development GO:0048483 23 12 0,000 0,02107929 0,04219527 ! gland morphogenesis GO:0022612 23 12 0,000 0,02107929 0,04215858 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,02107929 0,04212195 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,02107929 0,04208538 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,02107929 0,04204888 ! response to gamma radiation GO:0010332 20 12 0,000 0,02107929 0,04201245 ! regulation of epidermis development GO:0045682 17 12 0,000 0,02107929 0,04197607 ! intestinal absorption GO:0050892 19 12 0,000 0,02107929 0,04193976 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,02107929 0,04190351 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,02107929 0,04186732 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,02107929 0,0418312 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,02107929 0,04179514 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,02107929 0,04175914 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,02107929 0,0417232 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,02107929 0,04168733 ! microspike assembly GO:0030035 23 12 0,000 0,02107929 0,04165151 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,02107929 0,04161576 ! response to cold GO:0009409 14 12 0,000 0,02107929 0,04158007 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,02281635 0,04496796 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,02281635 0,04492946 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,02281635 0,04489103 ! cGMP metabolic process GO:0046068 16 13 0,000 0,02281635 0,04485266 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,02281635 0,04481436 ! water transport GO:0006833 17 13 0,000 0,02281635 0,04477612 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,02281635 0,04473795 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,02281635 0,04469984 ! lipid localization GO:0010876 24 13 0,000 0,02281635 0,0446618 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,02281635 0,04462382 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,02281635 0,04458591 ! organelle fusion GO:0048284 28 13 0,000 0,02281635 0,04454806 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,02281635 0,04451027 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,02281635 0,04447255 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,02281635 0,0444349 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,02281635 0,0443973 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,02281635 0,04435977 ! response to hexose stimulus GO:0009746 19 13 0,000 0,02281635 0,04432231 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,02281635 0,04428491 ! glutamate metabolic process GO:0006536 18 13 0,000 0,02281635 0,04424757 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,02281635 0,04421029 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,02281635 0,04417308 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,02281635 0,04413592 ! NAD metabolic process GO:0019674 21 13 0,000 0,02281635 0,04409883 ! exocrine system development GO:0035272 27 13 0,000 0,02281635 0,04406181 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,02281635 0,04402484 ! bone mineralization GO:0030282 15 13 0,000 0,02281635 0,04398794 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,02281635 0,0439511 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,02281635 0,04391432 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,02281635 0,0438776 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,02281635 0,04384095 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,02281635 0,04380435 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,02281635 0,04376782 ! genitalia development GO:0048806 15 13 0,000 0,02281635 0,04373134 ! regulation of cellular pH GO:0030641 20 13 0,000 0,02281635 0,04369493 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,02281635 0,04365858 ! cellular pigmentation GO:0033059 24 13 0,000 0,02281635 0,04362229 ! tissue regeneration GO:0042246 21 13 0,000 0,02281635 0,04358606 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,02281635 0,04354989 ! cofactor transport GO:0051181 19 13 0,000 0,02281635 0,04351378 ! NADP metabolic process GO:0006739 18 13 0,000 0,02281635 0,04347772 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,02281635 0,04344173 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,02281635 0,0434058 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,02281635 0,04336993 ! gas transport GO:0015669 18 13 0,000 0,02281635 0,04333412 ! regulation of RNA stability GO:0043487 28 13 0,000 0,02281635 0,04329836 ! heme biosynthetic process GO:0006783 20 13 0,000 0,02281635 0,04326267 ! regulation of axon extension GO:0030516 23 13 0,000 0,02281635 0,04322703 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,02281635 0,04319145 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,02281635 0,04315593 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,02281635 0,04312047 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,02281635 0,04308507 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,02281635 0,04304972 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,02281635 0,04301444 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,02455044 0,0462457 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,02455044 0,04620786 ! superoxide anion generation GO:0042554 18 14 0,000 0,02455044 0,04617008 ! neuron maturation GO:0042551 21 14 0,000 0,02455044 0,04613236 ! regulation of S phase GO:0033261 18 14 0,000 0,02455044 0,0460947 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,02455044 0,0460571 ! myotube differentiation GO:0014902 21 14 0,000 0,02455044 0,04601956 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,02455044 0,04598209 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,02455044 0,04594467 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,02455044 0,04590732 ! inositol metabolic process GO:0006020 20 14 0,000 0,02455044 0,04587003 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,02455044 0,0458328 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,02455044 0,04579562 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,02455044 0,04575851 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,02455044 0,04572146 ! gene silencing by RNA GO:0031047 20 14 0,000 0,02455044 0,04568447 ! response to cAMP GO:0051591 19 14 0,000 0,02455044 0,04564754 ! limbic system development GO:0021761 25 14 0,000 0,02455044 0,04561067 ! startle response GO:0001964 21 14 0,000 0,02455044 0,04557385 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,02455044 0,0455371 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,02455044 0,04550041 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,02455044 0,04546377 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,02455044 0,0454272 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,02455044 0,04539068 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,02455044 0,04535422 ! glycine metabolic process GO:0006544 22 14 0,000 0,02455044 0,04531782 ! pituitary gland development GO:0021983 23 14 0,000 0,02455044 0,04528148 ! cellular response to starvation GO:0009267 21 14 0,000 0,02455044 0,0452452 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,02455044 0,04520897 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,02455044 0,0451728 ! regulation of heart rate GO:0002027 23 14 0,000 0,02455044 0,04513669 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,02455044 0,04510064 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,02455044 0,04506465 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,02455044 0,04502871 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,02455044 0,04499283 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,02455044 0,04495701 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,02455044 0,04492124 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,02455044 0,04488554 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,02455044 0,04484988 ! axon cargo transport GO:0008088 27 14 0,000 0,02455044 0,04481429 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,02455044 0,04477875 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,02455044 0,04474327 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,02455044 0,04470784 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,02455044 0,04467247 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,02455044 0,04463716 ! mRNA splice site selection GO:0006376 26 14 0,000 0,02455044 0,0446019 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,02455044 0,0445667 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,02455044 0,04453155 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,02455044 0,04449646 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,02455044 0,04446142 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,02455044 0,04442644 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,02455044 0,04439151 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,02455044 0,04435664 ! muscle maintenance GO:0046716 19 14 0,000 0,02455044 0,04432182 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,02455044 0,04428706 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,02455044 0,04425235 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,02455044 0,0442177 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,02455044 0,0441831 ! cell killing GO:0001906 20 14 0,000 0,02455044 0,04414856 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,02455044 0,04411407 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,02455044 0,04407963 ! cilium assembly GO:0042384 20 14 0,000 0,02455044 0,04404524 ! peptide hormone secretion GO:0030072 23 14 0,000 0,02455044 0,04401091 ! positive regulation of cell size GO:0045793 20 15 0,000 0,02628154 0,04707753 ! metencephalon development GO:0022037 19 15 0,000 0,02628154 0,04704089 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,02628154 0,04700431 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,02628154 0,04696779 ! skin development GO:0043588 25 15 0,000 0,02628154 0,04693132 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,02628154 0,04689491 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,02628154 0,04685856 ! lipid phosphorylation GO:0046834 23 15 0,000 0,02628154 0,04682227 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,02628154 0,04678603 ! bile acid metabolic process GO:0008206 22 15 0,000 0,02628154 0,04674984 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,02628154 0,04671371 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,02628154 0,04667764 ! adult walking behavior GO:0007628 25 15 0,000 0,02628154 0,04664162 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,02628154 0,04660566 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,02628154 0,04656976 ! myoblast differentiation GO:0045445 27 15 0,000 0,02628154 0,04653391 ! centrosome cycle GO:0007098 16 15 0,000 0,02628154 0,04649811 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,02628154 0,04646237 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,02628154 0,04642669 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,02628154 0,04639105 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,02628154 0,04635548 ! cerebral cortex development GO:0021987 29 15 0,000 0,02628154 0,04631996 ! response to osmotic stress GO:0006970 22 15 0,000 0,02628154 0,04628449 ! vesicle coating GO:0006901 25 15 0,000 0,02628154 0,04624908 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,02628154 0,04621372 ! DNA integration GO:0015074 22 15 0,000 0,02628154 0,04617841 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,02628154 0,04614316 ! peptide secretion GO:0002790 27 15 0,000 0,02628154 0,04610797 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,02628154 0,04607282 ! regulation of vasodilation GO:0042312 24 15 0,000 0,02628154 0,04603773 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,02628154 0,0460027 ! neuron recognition GO:0008038 22 15 0,000 0,02628154 0,04596771 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,02628154 0,04593278 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,02628154 0,04589791 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,02628154 0,04586308 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,02628154 0,04582831 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,02628154 0,04579359 ! biomineral formation GO:0031214 18 15 0,000 0,02628154 0,04575893 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,02628154 0,04572432 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,02628154 0,04568975 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,02628154 0,04565525 ! dopamine metabolic process GO:0042417 30 15 0,000 0,02628154 0,04562079 ! organic cation transport GO:0015695 19 15 0,000 0,02628154 0,04558638 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,02628154 0,04555203 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,02628154 0,04551773 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,02628154 0,04548348 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,02628154 0,04544928 ! defense response to virus GO:0051607 27 15 0,000 0,02628154 0,04541513 ! peptide hormone processing GO:0016486 19 15 0,000 0,02628154 0,04538104 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,02628154 0,045347 ! protein secretion GO:0009306 27 16 0,000 0,02800967 0,04829254 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,02800967 0,04825636 ! hormone secretion GO:0046879 25 16 0,000 0,02800967 0,04822024 ! bone remodeling GO:0046849 24 16 0,000 0,02800967 0,04818418 ! endothelial cell migration GO:0043542 22 16 0,000 0,02800967 0,04814817 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,02800967 0,04811221 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,02800967 0,0480763 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,02800967 0,04804045 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,02800967 0,04800465 ! glial cell development GO:0021782 24 16 0,000 0,02800967 0,04796891 ! patterning of blood vessels GO:0001569 24 16 0,000 0,02800967 0,04793322 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,02800967 0,04789758 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,02800967 0,047862 ! protein polyubiquitination GO:0000209 26 16 0,000 0,02800967 0,04782646 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,02800967 0,04779098 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,02800967 0,04775556 ! regulation of protein binding GO:0043393 27 16 0,000 0,02800967 0,04772018 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,02800967 0,04768486 ! protein export from nucleus GO:0006611 24 16 0,000 0,02800967 0,04764959 ! negative regulation of immune response GO:0050777 28 16 0,000 0,02800967 0,04761437 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,02800967 0,04757921 ! DNA replication initiation GO:0006270 25 16 0,000 0,02800967 0,04754409 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,02800967 0,04750903 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,02800967 0,04747402 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,02800967 0,04743906 ! diencephalon development GO:0021536 25 16 0,000 0,02800967 0,04740416 ! oogenesis GO:0048477 23 16 0,000 0,02800967 0,0473693 ! G1 phase GO:0051318 27 16 0,000 0,02800967 0,04733449 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,02800967 0,04729974 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,02800967 0,04726504 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,02800967 0,04723039 ! steroid catabolic process GO:0006706 22 16 0,000 0,02800967 0,04719579 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,02800967 0,04716123 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,02800967 0,04712674 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,02800967 0,04709229 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,02800967 0,04705789 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,02800967 0,04702354 ! sperm-egg recognition GO:0035036 16 16 0,000 0,02800967 0,04698924 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,02800967 0,04695499 ! nerve development GO:0021675 18 16 0,000 0,02800967 0,04692079 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,02800967 0,04688664 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,02800967 0,04685254 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,02973484 0,04970212 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,02973484 0,04966603 ! negative regulation of defense response GO:0031348 19 17 0,000 0,02973484 0,04962999 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,02973484 0,049594 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,02973484 0,04955806 ! glycerol metabolic process GO:0006071 20 17 0,000 0,02973484 0,04952217 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,02973484 0,04948634 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,02973484 0,04945056 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,02973484 0,04941483 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,02973484 0,04937915 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,02973484 0,04934352 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,02973484 0,04930795 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,02973484 0,04927242 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,02973484 0,04923695 ! memory GO:0007613 25 17 0,000 0,02973484 0,04920153 ! keratinization GO:0031424 17 17 0,000 0,02973484 0,04916616 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,02973484 0,04913083 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,02973484 0,04909557 ! retinoid metabolic process GO:0001523 22 17 0,000 0,02973484 0,04906035 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,02973484 0,04902518 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,02973484 0,04899006 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,02973484 0,04895499 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,02973484 0,04891997 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,02973484 0,04888501 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,02973484 0,04885009 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,02973484 0,04881522 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,02973484 0,0487804 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,02973484 0,04874563 ! membrane budding GO:0006900 29 17 0,000 0,02973484 0,04871091 ! heme metabolic process GO:0042168 27 17 0,000 0,02973484 0,04867624 ! actin filament bundle formation GO:0051017 26 17 0,000 0,02973484 0,04864162 ! neuromuscular junction development GO:0007528 23 17 0,000 0,02973484 0,04860705 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,02973484 0,04857253 ! body fluid secretion GO:0007589 27 17 0,000 0,02973484 0,04853806 ! stem cell differentiation GO:0048863 36 17 0,000 0,02973484 0,04850363 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,02973484 0,04846926 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,02973484 0,04843493 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,02973484 0,04840065 ! sensory perception of pain GO:0019233 23 17 0,000 0,02973484 0,04836642 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,02973484 0,04833224 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,02973484 0,04829811 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,02973484 0,04826402 ! synaptogenesis GO:0007416 24 17 0,000 0,02973484 0,04822999 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,02973484 0,048196 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,02973484 0,04816206 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,02973484 0,04812816 ! cell-cell junction organization GO:0045216 25 17 0,000 0,02973484 0,04809432 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,02973484 0,04806052 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,02973484 0,04802677 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,02973484 0,04799307 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,02973484 0,04795941 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,02973484 0,0479258 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,02973484 0,04789224 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,03145704 0,05063064 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,03145704 0,05059523 ! positive regulation of translation GO:0045727 28 18 0,000 0,03145704 0,05055988 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,03145704 0,05052457 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,03145704 0,05048931 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,03145704 0,0504541 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,03145704 0,05041894 ! cAMP metabolic process GO:0046058 33 18 0,000 0,03145704 0,05038383 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,03145704 0,05034877 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,03145704 0,05031376 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,03145704 0,05027879 ! axis specification GO:0009798 26 18 0,000 0,03145704 0,05024388 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,03145704 0,05020901 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,03145704 0,05017419 ! pancreas development GO:0031016 26 18 0,000 0,03145704 0,05013942 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,03145704 0,0501047 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,03145704 0,05007002 ! glutamine metabolic process GO:0006541 23 18 0,000 0,03145704 0,0500354 ! response to retinoic acid GO:0032526 25 18 0,000 0,03145704 0,05000082 ! pigmentation during development GO:0048066 31 18 0,000 0,03145704 0,04996629 ! central nervous system neuron development GO:0021954 30 18 0,000 0,03145704 0,0499318 ! fucose metabolic process GO:0006004 26 18 0,000 0,03145704 0,04989737 ! response to fungus GO:0009620 19 18 0,000 0,03145704 0,04986298 ! peptide cross-linking GO:0018149 31 18 0,000 0,03145704 0,04982864 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,03145704 0,04979434 ! heart process GO:0003015 27 18 0,000 0,03145704 0,0497601 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,03145704 0,0497259 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,03145704 0,04969175 ! visual learning GO:0008542 35 18 0,000 0,03145704 0,04965764 ! somitogenesis GO:0001756 24 18 0,000 0,03145704 0,04962358 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,03145704 0,04958957 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,03145704 0,0495556 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,03145704 0,04952169 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,03145704 0,04948781 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,03145704 0,04945399 ! vitamin transport GO:0051180 24 18 0,000 0,03145704 0,04942021 ! hormone transport GO:0009914 27 18 0,000 0,03145704 0,04938647 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,03145704 0,04935278 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,03145704 0,04931914 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,03145704 0,04928555 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,03145704 0,049252 ! cell-cell recognition GO:0009988 20 18 0,000 0,03145704 0,04921849 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,03145704 0,04918503 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,03145704 0,04915162 ! regulation of glucose import GO:0046324 21 18 0,000 0,03145704 0,04911825 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,03145704 0,04908493 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,03145704 0,04905165 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,03145704 0,04901842 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,03317628 0,05166245 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,03317628 0,05162749 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,03317628 0,05159259 ! positive regulation of ossification GO:0045778 30 19 0,000 0,03317628 0,05155773 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,03317628 0,05152292 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,03317628 0,05148815 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,03317628 0,05145343 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,03317628 0,05141876 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,03317628 0,05138413 GO:0010675|regulation of cellular carbohydrate metabolic process, ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,03317628 0,05134955 ! regeneration GO:0031099 32 19 0,000 0,03317628 0,05131502 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,03317628 0,05128054 ! response to alkaloid GO:0043279 32 19 0,000 0,03317628 0,0512461 ! sensory perception of taste GO:0050909 23 19 0,000 0,03317628 0,0512117 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,03317628 0,05117736 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,03317628 0,05114305 ! smooth muscle contraction GO:0006939 36 19 0,000 0,03317628 0,0511088 ! peroxisome organization GO:0007031 29 19 0,000 0,03317628 0,05107459 ! digestive system process GO:0022600 30 19 0,000 0,03317628 0,05104043 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,03317628 0,05100631 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,03317628 0,05097224 ! response to vitamin A GO:0033189 26 19 0,000 0,03317628 0,05093821 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,03317628 0,05090423 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,03317628 0,05087029 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,03317628 0,0508364 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,03317628 0,05080255 ! response to starvation GO:0042594 30 19 0,000 0,03317628 0,05076875 ! sex determination GO:0007530 29 19 0,000 0,03317628 0,050735 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,03317628 0,05070129 ! plasma membrane fusion GO:0045026 23 19 0,000 0,03317628 0,05066762 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,03317628 0,050634 ! cytolysis GO:0019835 20 19 0,000 0,03317628 0,05060042 ! renal system process GO:0003014 35 19 0,000 0,03317628 0,05056689 ! vasodilation GO:0042311 33 19 0,000 0,03317628 0,0505334 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,03317628 0,05049996 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,03317628 0,05046656 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,03317628 0,0504332 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,03317628 0,05039989 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,03317628 0,05036663 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,03317628 0,0503334 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,03317628 0,05030022 ! sarcomere organization GO:0045214 23 19 0,000 0,03317628 0,05026709 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,03317628 0,05023399 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,03317628 0,05020095 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,03317628 0,05016794 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,03317628 0,05013498 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,03317628 0,05010206 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,03317628 0,05006918 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,03317628 0,05003635 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,03317628 0,05000356 ! protein stabilization GO:0050821 26 19 0,000 0,03317628 0,04997082 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,03489256 0,05252153 ! iron ion transport GO:0006826 37 20 0,000 0,03489256 0,05248718 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,03489256 0,05245288 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,03489256 0,05241861 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,03489256 0,0523844 ! response to vitamin GO:0033273 29 20 0,000 0,03489256 0,05235023 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,03489256 0,0523161 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,03489256 0,05228202 ! spinal cord development GO:0021510 31 20 0,000 0,03489256 0,05224798 ! response to ethanol GO:0045471 37 20 0,000 0,03489256 0,05221399 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,03489256 0,05218004 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,03489256 0,05214613 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,03489256 0,05211227 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,03489256 0,05207846 ! chromosome condensation GO:0030261 31 20 0,000 0,03489256 0,05204468 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,03489256 0,05201095 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,03489256 0,05197727 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,03489256 0,05194362 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,03489256 0,05191003 ! pallium development GO:0021543 38 20 0,000 0,03489256 0,05187647 ! DNA modification GO:0006304 28 20 0,000 0,03489256 0,05184296 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,03489256 0,05180949 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,03489256 0,05177606 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,03489256 0,05174268 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,03489256 0,05170934 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,03489256 0,05167605 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,03489256 0,05164279 ! collagen catabolic process GO:0030574 25 20 0,000 0,03489256 0,05160958 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,03489256 0,05157641 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,03489256 0,05154329 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,03489256 0,0515102 ! actin filament-based movement GO:0030048 34 20 0,000 0,03489256 0,05147716 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,0366059 0,05397024 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,0366059 0,05393567 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,0366059 0,05390114 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,0366059 0,05386665 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,0366059 0,05383221 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,0366059 0,05379781 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,0366059 0,05376346 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,0366059 0,05372915 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,0366059 0,05369488 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,0366059 0,05366066 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,0366059 0,05362648 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,0366059 0,05359235 ! protein amino acid acylation GO:0043543 37 21 0,000 0,0366059 0,05355826 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,0366059 0,05352421 ! vesicle docking GO:0048278 27 21 0,000 0,0366059 0,0534902 ! phototransduction GO:0007602 25 21 0,000 0,0366059 0,05345624 ! dendrite development GO:0016358 35 21 0,000 0,0366059 0,05342232 ! visual behavior GO:0007632 39 21 0,000 0,0366059 0,05338845 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,0366059 0,05335461 ! ovarian follicle development GO:0001541 30 21 0,000 0,0366059 0,05332082 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,0366059 0,05328708 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,0366059 0,05325337 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,0366059 0,05321971 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,0366059 0,05318609 ! cell aging GO:0007569 32 21 0,000 0,0366059 0,05315251 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,0366059 0,05311898 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,0366059 0,05308549 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,0366059 0,05305204 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,0366059 0,05301863 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,0366059 0,05298526 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,0366059 0,05295194 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,0366059 0,05291865 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,0366059 0,05288541 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,0366059 0,05285222 ! fatty acid transport GO:0015908 30 21 0,000 0,0366059 0,05281906 ! immunoglobulin production GO:0002377 33 21 0,000 0,0366059 0,05278594 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,0366059 0,05275287 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,0366059 0,05271984 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,0366059 0,05268685 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,0366059 0,0526539 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,0366059 0,05262099 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,0366059 0,05258812 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,0366059 0,05255529 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,0366059 0,05252251 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,0366059 0,05248976 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,0366059 0,05245706 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,0366059 0,0524244 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,0366059 0,05239177 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,0366059 0,05235919 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,0366059 0,05232665 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,0383163 0,05473757 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,0383163 0,05470359 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,0383163 0,05466966 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,0383163 0,05463577 ! viral genome replication GO:0019079 29 22 0,000 0,0383163 0,05460191 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,0383163 0,0545681 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,0383163 0,05453434 ! leukocyte adhesion GO:0007159 38 22 0,000 0,0383163 0,05450061 ! molting cycle process GO:0022404 40 22 0,000 0,0383163 0,05446693 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,0383163 0,05443329 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,0383163 0,05439968 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,0383163 0,05436613 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,0383163 0,05433261 ! vasculogenesis GO:0001570 33 22 0,000 0,0383163 0,05429913 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,0383163 0,0542657 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,0383163 0,0542323 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,0383163 0,05419895 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,0383163 0,05416564 ! lysosome organization GO:0007040 37 22 0,000 0,0383163 0,05413236 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,0383163 0,05409913 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,0383163 0,05406594 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,0383163 0,0540328 ! regulation of behavior GO:0050795 38 22 0,000 0,0383163 0,05399969 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,0383163 0,05396662 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,0383163 0,05393359 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,0383163 0,05390061 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,0383163 0,05386766 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,0383163 0,05383475 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,0383163 0,05380189 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,0383163 0,05376906 ! blastocyst development GO:0001824 37 22 0,000 0,0383163 0,05373627 ! neural tube closure GO:0001843 33 22 0,000 0,0383163 0,05370353 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,0383163 0,05367082 ! protein tetramerization GO:0051262 39 22 0,000 0,0383163 0,05363816 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,04002376 0,05599431 ! neuron fate commitment GO:0048663 32 23 0,000 0,04002376 0,05596027 ! embryonic pattern specification GO:0009880 31 23 0,000 0,04002376 0,05592627 ! myelination GO:0042552 35 23 0,000 0,04002376 0,05589231 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,04002376 0,0558584 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,04002376 0,05582452 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,04002376 0,05579069 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,04002376 0,0557569 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,04002376 0,05572315 ! vesicle targeting GO:0006903 32 23 0,000 0,04002376 0,05568944 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,04002376 0,05565577 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,04002376 0,05562214 ! osteoblast differentiation GO:0001649 40 23 0,000 0,04002376 0,05558855 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,04002376 0,055555 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,04002376 0,0555215 ! interaction with host GO:0051701 37 23 0,000 0,04002376 0,05548803 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,04002376 0,0554546 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,04002376 0,05542122 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,04002376 0,05538787 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,04002376 0,05535456 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,04002376 0,0553213 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,04002376 0,05528807 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,04002376 0,05525489 ! cell fate determination GO:0001709 45 23 0,000 0,04002376 0,05522174 ! pentose metabolic process GO:0019321 31 23 0,000 0,04002376 0,05518863 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,04002376 0,05515557 ! spermatid development GO:0007286 33 23 0,000 0,04002376 0,05512254 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,04002376 0,05508955 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,04002376 0,0550566 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,04002376 0,05502369 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,04002376 0,05499082 ! telomere organization GO:0032200 32 23 0,000 0,04002376 0,05495799 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,04002376 0,0549252 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,04002376 0,05489245 ! regulation of amine transport GO:0051952 38 23 0,000 0,04002376 0,05485974 ! liver development GO:0001889 40 23 0,000 0,04002376 0,05482706 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,04172828 0,057128 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,04172828 0,05709402 ! initiation of viral infection GO:0019059 42 24 0,000 0,04172828 0,05706007 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,04172828 0,05702617 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,04172828 0,05699231 ! superoxide metabolic process GO:0006801 32 24 0,000 0,04172828 0,05695848 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,04172828 0,0569247 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,04172828 0,05689096 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,04172828 0,05685725 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,04172828 0,05682359 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,04172828 0,05678997 ! vacuole organization GO:0007033 39 24 0,000 0,04172828 0,05675638 ! response to toxin GO:0009636 38 24 0,000 0,04172828 0,05672284 ! negative regulation of cell development GO:0010721 56 24 0,000 0,04172828 0,05668933 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,04172828 0,05665587 ! base-excision repair GO:0006284 31 24 0,000 0,04172828 0,05662244 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,04172828 0,05658906 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,04172828 0,05655571 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,04172828 0,0565224 ! glutathione metabolic process GO:0006749 29 24 0,000 0,04172828 0,05648914 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,04172828 0,05645591 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,04172828 0,05642272 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,04172828 0,05638957 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,04342987 0,05865456 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,04342987 0,05862013 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,04342987 0,05858575 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,04342987 0,05855141 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,04342987 0,05851711 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,04342987 0,05848285 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,04342987 0,05844863 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,04342987 0,05841445 ! peptide transport GO:0015833 43 25 0,000 0,04342987 0,05838031 ! male gonad development GO:0008584 33 25 0,000 0,04342987 0,05834621 ! iron ion homeostasis GO:0055072 39 25 0,000 0,04342987 0,05831215 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,04342987 0,05827813 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,04342987 0,05824414 ! phospholipid transport GO:0015914 35 25 0,000 0,04342987 0,0582102 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,04342987 0,0581763 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,04342987 0,05814244 ! detection of light stimulus GO:0009583 30 25 0,000 0,04342987 0,05810861 ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,04342987 0,05807483 ! leukocyte proliferation GO:0070661 39 25 0,000 0,04342987 0,05804109 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,04342987 0,05800738 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,04512854 0,06024123 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,04512854 0,06020629 ! translational initiation GO:0006413 43 26 0,000 0,04512854 0,06017139 ! regulation of pH GO:0006885 36 26 0,000 0,04512854 0,06013653 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,04512854 0,06010171 ! circadian rhythm GO:0007623 42 26 0,000 0,04512854 0,06006693 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,04512854 0,06003218 ! post-embryonic development GO:0009791 42 26 0,000 0,04512854 0,05999748 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,04512854 0,05996282 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,04512854 0,0599282 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,04512854 0,05989362 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,04512854 0,05985908 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,04512854 0,05982458 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,04512854 0,05979012 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,04512854 0,0597557 ! regulation of coagulation GO:0050818 39 26 0,000 0,04512854 0,05972132 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,04682429 0,06192977 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,04682429 0,06189418 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,04682429 0,06185863 ! membrane docking GO:0022406 39 27 0,000 0,04682429 0,06182312 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,04682429 0,06178765 ! catechol metabolic process GO:0009712 43 27 0,000 0,04682429 0,06175222 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,04682429 0,06171683 ! acute-phase response GO:0006953 42 27 0,000 0,04682429 0,06168149 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,04682429 0,06164618 ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,04682429 0,06161091 ! response to ionizing radiation GO:0010212 47 27 0,000 0,04682429 0,06157569 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,04682429 0,0615405 ! natural killer cell activation GO:0030101 35 27 0,000 0,04682429 0,06150535 ! lipid oxidation GO:0034440 38 27 0,000 0,04682429 0,06147025 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,04682429 0,06143518 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,04682429 0,06140016 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,04682429 0,06136517 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,04682429 0,06133022 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,04682429 0,06129532 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,04682429 0,06126045 ! gene silencing GO:0016458 41 27 0,000 0,04682429 0,06122562 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,04851713 0,06340307 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,04851713 0,06336706 ! phenol metabolic process GO:0018958 44 28 0,000 0,04851713 0,0633311 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,04851713 0,06329518 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,04851713 0,06325929 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,04851713 0,06322345 ! cell junction assembly GO:0034329 56 28 0,000 0,04851713 0,06318765 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,04851713 0,06315189 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,04851713 0,06311617 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,04851713 0,06308049 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,04851713 0,06304486 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,04851713 0,06300926 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,04851713 0,0629737 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,04851713 0,06293818 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,04851713 0,0629027 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,04851713 0,06286726 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,04851713 0,06283187 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,04851713 0,06279651 ! mesoderm formation GO:0001707 46 28 0,000 0,04851713 0,06276119 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,04851713 0,06272591 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,04851713 0,06269067 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,04851713 0,06265547 ! ensheathment of neurons GO:0007272 43 28 0,000 0,04851713 0,06262031 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,04851713 0,06258519 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,04851713 0,06255011 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,04851713 0,06251507 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,04851713 0,06248006 ! placenta development GO:0001890 37 28 0,000 0,04851713 0,0624451 ! regulation of B cell activation GO:0050864 42 28 0,000 0,04851713 0,06241018 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,05020705 0,06454792 ! regulation of innate immune response GO:0045088 38 29 0,000 0,05020705 0,06451186 ! ovulation cycle process GO:0022602 41 29 0,000 0,05020705 0,06447584 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,05020705 0,06443986 ! protein targeting to membrane GO:0006612 53 29 0,000 0,05020705 0,06440392 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,05020705 0,06436802 ! mismatch repair GO:0006298 34 29 0,000 0,05020705 0,06433216 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,05020705 0,06429634 ! formation of primary germ layer GO:0001704 48 29 0,000 0,05020705 0,06426056 ! telencephalon development GO:0021537 52 29 0,000 0,05020705 0,06422482 ! eye morphogenesis GO:0048592 51 29 0,000 0,05020705 0,06418912 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,05020705 0,06415346 ! tissue homeostasis GO:0001894 42 29 0,000 0,05020705 0,06411784 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,05189408 0,0662355 ! collagen metabolic process GO:0032963 40 30 0,000 0,05189408 0,06619877 ! organic anion transport GO:0015711 51 30 0,000 0,05189408 0,06616207 ! cholesterol transport GO:0030301 46 30 0,000 0,05189408 0,06612541 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,05189408 0,0660888 ! spliceosome assembly GO:0000245 49 30 0,000 0,05189408 0,06605223 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,05189408 0,06601569 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,05189408 0,0659792 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,05189408 0,06594275 ! ceramide metabolic process GO:0006672 43 30 0,000 0,05189408 0,06590634 ! ovulation cycle GO:0042698 43 30 0,000 0,05189408 0,06586996 ! hindbrain development GO:0030902 45 30 0,000 0,05189408 0,06583363 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,05189408 0,06579734 ! adult locomotory behavior GO:0008344 47 30 0,000 0,05189408 0,06576109 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,05189408 0,06572488 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,05189408 0,0656887 ! response to heat GO:0009408 41 30 0,000 0,05189408 0,06565257 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,05189408 0,06561648 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,05189408 0,06558043 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,0535782 0,06767153 ! negative regulation of secretion GO:0051048 49 31 0,000 0,0535782 0,06763439 ! mammary gland development GO:0030879 57 31 0,000 0,0535782 0,06759729 ! glial cell differentiation GO:0010001 55 31 0,000 0,0535782 0,06756023 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,0535782 0,06752321 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,0535782 0,06748623 ! odontogenesis GO:0042476 50 31 0,000 0,0535782 0,06744929 ! segmentation GO:0035282 41 31 0,000 0,0535782 0,06741239 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,0535782 0,06737553 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,0535782 0,06733872 ! metanephros development GO:0001656 58 31 0,000 0,0535782 0,06730194 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,0535782 0,0672652 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,0535782 0,06722851 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,0535782 0,06719185 ! cell fate specification GO:0001708 37 31 0,000 0,0535782 0,06715523 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,0535782 0,06711866 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,0535782 0,06708212 ! RNA modification GO:0009451 40 31 0,000 0,0535782 0,06704562 ! regulation of muscle development GO:0048634 48 32 0,000 0,05525942 0,06911184 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,05525942 0,06907428 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,05525942 0,06903676 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,05525942 0,06899928 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,05525942 0,06896184 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,05525942 0,06892444 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,05525942 0,06888709 ! peripheral nervous system development GO:0007422 53 32 0,000 0,05525942 0,06884977 ! regulation of protein stability GO:0031647 48 32 0,000 0,05525942 0,06881249 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,05525942 0,06877526 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,05525942 0,06873806 ! cytokine production GO:0001816 44 32 0,000 0,05525942 0,0687009 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,05525942 0,06866379 ! vesicle localization GO:0051648 47 32 0,000 0,05525942 0,06862671 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,05693776 0,07067288 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,05693776 0,07063476 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,05693776 0,07059668 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,05693776 0,07055864 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,05693776 0,07052065 ! ear morphogenesis GO:0042471 42 33 0,000 0,05693776 0,07048269 ! cell junction organization GO:0034330 63 33 0,000 0,05693776 0,07044478 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,05693776 0,07040691 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,05693776 0,07036907 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,05693776 0,07033128 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,05693776 0,07029353 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,05693776 0,07025582 ! female gonad development GO:0008585 49 33 0,000 0,05693776 0,07021815 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,05693776 0,07018052 ! positive regulation of cell development GO:0010720 54 33 0,000 0,05693776 0,07014293 ! lipid homeostasis GO:0055088 55 33 0,000 0,05693776 0,07010538 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,05693776 0,07006787 ! regulation of proteolysis GO:0030162 50 33 0,000 0,05693776 0,0700304 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,05693776 0,06999297 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,05693776 0,06995558 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,05693776 0,06991823 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,05693776 0,06988092 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,05861321 0,07189887 ! mRNA catabolic process GO:0006402 48 34 0,000 0,05861321 0,07186054 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,05861321 0,07182226 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,05861321 0,07178402 ! feeding behavior GO:0007631 45 34 0,000 0,05861321 0,07174581 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,05861321 0,07170765 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,05861321 0,07166953 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,05861321 0,07163145 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,05861321 0,0715934 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,05861321 0,0715554 ! neuron migration GO:0001764 46 34 0,000 0,05861321 0,07151744 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,05861321 0,07147952 ! female gamete generation GO:0007292 43 34 0,000 0,05861321 0,07144164 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,05861321 0,0714038 ! aerobic respiration GO:0009060 47 34 0,000 0,05861321 0,071366 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,05861321 0,07132824 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,05861321 0,07129052 ! embryonic organ development GO:0048568 45 34 0,000 0,05861321 0,07125284 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,05861321 0,0712152 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,06028578 0,07320871 ! Notch signaling pathway GO:0007219 56 35 0,000 0,06028578 0,07317007 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,06028578 0,07313148 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,06028578 0,07309293 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,06028578 0,07305442 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,06028578 0,07301595 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,06028578 0,07297752 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,06028578 0,07293913 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,06028578 0,07290078 GO:0015986|ATP synthesis coupled proton transport, ! glycogen metabolic process GO:0005977 48 35 0,000 0,06028578 0,07286247 ! pigment metabolic process GO:0042440 61 35 0,000 0,06028578 0,07282421 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,06028578 0,07278598 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,06028578 0,07274779 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,06195547 0,07472343 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,06195547 0,07468427 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,06195547 0,07464515 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,06195547 0,07460607 ! negative regulation of binding GO:0051100 58 36 0,000 0,06195547 0,07456702 ! organic ether metabolic process GO:0018904 46 36 0,000 0,06195547 0,07452803 ! tissue remodeling GO:0048771 62 36 0,000 0,06195547 0,07448907 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,06195547 0,07445015 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,06195547 0,07441127 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,06195547 0,07437243 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,06195547 0,07433364 ! glucan metabolic process GO:0044042 49 36 0,000 0,06195547 0,07429488 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,06362229 0,07625392 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,06362229 0,07621421 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,06362229 0,07617453 ! learning GO:0007612 67 37 0,000 0,06362229 0,0761349 ! ion transmembrane transport GO:0034220 56 37 0,000 0,06362229 0,07609531 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,06362229 0,07605576 ! regulation of protein secretion GO:0050708 51 37 0,000 0,06362229 0,07601625 ! amino acid activation GO:0043038 52 37 0,000 0,06362229 0,07597678 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,06362229 0,07593735 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,06528625 0,07788297 ! gliogenesis GO:0042063 71 38 0,000 0,06528625 0,0778426 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,06528625 0,07780227 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,06528625 0,07776198 ! phagocytosis GO:0006909 60 38 0,000 0,06528625 0,07772173 ! pigmentation GO:0043473 74 38 0,000 0,06528625 0,07768152 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,06694734 0,0796168 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,06694734 0,07957565 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,06694734 0,07953455 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,06694734 0,07949349 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,06694734 0,07945247 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,06694734 0,0794115 ! male sex differentiation GO:0046661 53 39 0,000 0,06694734 0,07937056 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,06694734 0,07932967 ! chromatin remodeling GO:0006338 68 39 0,000 0,06694734 0,07928882 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,06694734 0,07924801 ! JNK cascade GO:0007254 54 39 0,000 0,06694734 0,07920725 ! developmental growth GO:0048589 62 39 0,000 0,06694734 0,07916652 ! cell growth GO:0016049 61 39 0,000 0,06694734 0,07912584 ! synapse organization GO:0050808 55 39 0,000 0,06694734 0,0790852 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,06860558 0,08100248 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,06860558 0,08096092 ! regulation of tube size GO:0035150 60 40 0,000 0,06860558 0,0809194 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,06860558 0,08087793 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,06860558 0,08083649 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,06860558 0,0807951 ! peptide metabolic process GO:0006518 56 40 0,000 0,06860558 0,08075375 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,06860558 0,08071245 ! inner ear development GO:0048839 57 40 0,000 0,06860558 0,08067118 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,06860558 0,08062996 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,06860558 0,08058878 ! double-strand break repair GO:0006302 67 40 0,000 0,06860558 0,08054764 ! B cell differentiation GO:0030183 62 40 0,000 0,06860558 0,08050655 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,06860558 0,0804655 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,06860558 0,08042448 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,06860558 0,08038351 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,06860558 0,08034258 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,07026097 0,0822393 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,07026097 0,08219747 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,07026097 0,08215568 ! glucose transport GO:0015758 52 41 0,000 0,07026097 0,08211393 ! endosome transport GO:0016197 71 41 0,000 0,07026097 0,08207223 ! striated muscle contraction GO:0006941 62 41 0,000 0,07026097 0,08203057 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,07026097 0,08198895 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,07026097 0,08194737 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,07026097 0,08190584 ! biopolymer methylation GO:0043414 62 41 0,000 0,07026097 0,08186435 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,07026097 0,0818229 ! mitochondrial transport GO:0006839 60 42 0,000 0,0719135 0,08370499 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,0719135 0,08366265 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,0719135 0,08362035 ! cellular component disassembly GO:0022411 64 42 0,000 0,0719135 0,0835781 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,0719135 0,08353589 ! hexose transport GO:0008645 54 42 0,000 0,0719135 0,08349372 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,0719135 0,08345159 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,0719135 0,08340951 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,0719135 0,08336747 ! excretion GO:0007588 63 42 0,000 0,0719135 0,08332547 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,0719135 0,08328351 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,0719135 0,0832416 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,0719135 0,08319973 ! regulation of cell shape GO:0008360 78 42 0,000 0,0719135 0,0831579 ! positive regulation of binding GO:0051099 59 43 0,000 0,0735632 0,08502279 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,0735632 0,08498009 ! leukocyte migration GO:0050900 60 43 0,000 0,0735632 0,08493743 ! neuromuscular process GO:0050905 79 43 0,000 0,0735632 0,08489481 ! activation of caspase activity GO:0006919 65 43 0,000 0,0735632 0,08485224 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,0735632 0,0848097 ! tRNA processing GO:0008033 49 43 0,000 0,0735632 0,08476721 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,0735632 0,08472477 ! vesicle organization GO:0016050 79 43 0,000 0,0735632 0,08468236 ! methylation GO:0032259 64 43 0,000 0,0735632 0,08464 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,07521006 0,08649156 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,07521006 0,08644834 ! regulation of action potential GO:0001508 71 44 0,000 0,07521006 0,08640516 ! regulation of ion transport GO:0043269 57 44 0,000 0,07521006 0,08636202 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,07521006 0,08631893 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,07521006 0,08627587 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,07521006 0,08623287 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,07521006 0,0861899 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,07521006 0,08614698 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,07521006 0,0861041 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,07521006 0,08606126 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,07521006 0,08601846 ! RNA catabolic process GO:0006401 64 45 0,000 0,07685408 0,08785506 ! positive regulation of defense response GO:0031349 59 45 0,000 0,07685408 0,08781142 ! regulation of translational initiation GO:0006446 64 45 0,000 0,07685408 0,08776782 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,07685408 0,08772426 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,07685408 0,08768075 ! cell recognition GO:0008037 58 45 0,000 0,07685408 0,08763727 ! cell maturation GO:0048469 60 45 0,000 0,07685408 0,08759385 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,07685408 0,08755046 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,07849528 0,08937581 ! cell redox homeostasis GO:0045454 63 46 0,000 0,07849528 0,08933158 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,07849528 0,0892874 ! regulation of ossification GO:0030278 71 46 0,000 0,07849528 0,08924327 ! histone modification GO:0016570 68 46 0,000 0,07849528 0,08919918 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,07849528 0,08915513 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,08013365 0,09097107 ! viral infectious cycle GO:0019058 71 47 0,000 0,08013365 0,09092619 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,08013365 0,09088135 ! endocrine system development GO:0035270 83 47 0,000 0,08013365 0,09083656 ! covalent chromatin modification GO:0016569 75 47 0,000 0,08013365 0,09079182 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,08013365 0,09074711 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,08013365 0,09070245 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,08013365 0,09065784 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,08013365 0,09061327 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,08013365 0,09056874 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,08013365 0,09052426 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,08013365 0,09047982 ! chloride transport GO:0006821 67 48 0,000 0,0817692 0,09228124 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,0817692 0,09223598 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,0817692 0,09219076 ! response to temperature stimulus GO:0009266 62 48 0,000 0,0817692 0,09214559 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,0817692 0,09210047 ! gastrulation GO:0007369 73 48 0,000 0,0817692 0,09205539 ! heart morphogenesis GO:0003007 65 48 0,000 0,0817692 0,09201035 ! regulation of DNA replication GO:0006275 75 48 0,000 0,0817692 0,09196536 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,0817692 0,09192041 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,0817692 0,0918755 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,0817692 0,09183064 ! regulation of endocytosis GO:0030100 63 48 0,000 0,0817692 0,09178583 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,0817692 0,09174105 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,0817692 0,09169632 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,08340194 0,0934817 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,08340194 0,09343617 ! sensory perception of smell GO:0007608 61 49 0,000 0,08340194 0,09339068 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,08340194 0,09334523 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,08340194 0,09329983 ! RNA elongation GO:0006354 62 49 0,000 0,08340194 0,09325448 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,08340194 0,09320916 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,08340194 0,09316389 ! germ cell development GO:0007281 68 49 0,000 0,08340194 0,09311867 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,08340194 0,09307349 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,08340194 0,09302835 ! cartilage development GO:0051216 70 49 0,000 0,08340194 0,09298326 ! ear development GO:0043583 72 50 0,000 0,08503187 0,0947545 ! membrane fusion GO:0006944 80 50 0,000 0,08503187 0,09470862 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,08503187 0,09466277 ! lipid modification GO:0030258 73 50 0,000 0,08503187 0,09461698 ! positive regulation of growth GO:0045927 67 50 0,000 0,08503187 0,09457122 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,08503187 0,09452552 ! proton transport GO:0015992 75 50 0,000 0,08503187 0,09447985 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,08503187 0,09443423 ! positive regulation of secretion GO:0051047 71 51 0,000 0,08665899 0,09619482 ! hydrogen transport GO:0006818 77 51 0,000 0,08665899 0,09614842 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,08665899 0,09610206 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of cell migration GO:0030335 92 51 0,000 0,08665899 0,09605575 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,08665899 0,09600948 ! adult behavior GO:0030534 80 51 0,000 0,08665899 0,09596325 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,08665899 0,09591707 ! transition metal ion transport GO:0000041 74 52 0,000 0,08828331 0,09766793 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,08828331 0,09762097 ! aging GO:0007568 79 52 0,000 0,08828331 0,09757406 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,08828331 0,09752719 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,08828331 0,09748037 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,08990484 0,09922319 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,08990484 0,0991756 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,08990484 0,09912806 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,08990484 0,09908056 ! kidney development GO:0001822 90 53 0,000 0,08990484 0,09903311 ! single fertilization GO:0007338 59 53 0,000 0,08990484 0,0989857 ! amino acid transport GO:0006865 84 54 0,000 0,09152357 0,10071972 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,09152357 0,10067156 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,09152357 0,10062343 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,09152357 0,10057536 ! DNA catabolic process GO:0006308 67 54 0,000 0,09152357 0,10052733 ! detection of external stimulus GO:0009581 66 54 0,000 0,09152357 0,10047934 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,09152357 0,1004314 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,09152357 0,10038351 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,09152357 0,10033566 ! exocytosis GO:0006887 74 55 0,000 0,09313952 0,10205855 ! mesoderm development GO:0007498 76 55 0,000 0,09313952 0,10200996 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,09313952 0,1019614 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,09313952 0,1019129 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,09475269 0,10362872 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,09475269 0,10357946 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,09475269 0,10353026 ! positive regulation of cell motion GO:0051272 99 56 0,000 0,09475269 0,1034811 ! negative regulation of protein kinase activity GO:0006469 99 57 0,000 0,09636308 0,10518989 ! carbohydrate transport GO:0008643 74 57 0,000 0,09636308 0,10513999 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,09636308 0,10509013 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,09636308 0,10504033 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,09636308 0,10499057 ! camera-type eye development GO:0043010 88 57 0,000 0,09636308 0,10494086 ! secondary metabolic process GO:0019748 84 57 0,000 0,09636308 0,10489119 ! developmental maturation GO:0021700 75 57 0,000 0,09636308 0,10484158 ! gonad development GO:0008406 79 57 0,000 0,09636308 0,104792 ! negative regulation of kinase activity GO:0033673 100 58 0,000 0,0979707 0,10648989 ! viral reproductive process GO:0022415 87 58 0,000 0,0979707 0,10643959 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,0979707 0,10638933 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,0979707 0,10633913 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,0979707 0,10628897 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,09957555 0,10797915 ! activation of MAPK activity GO:0000187 84 59 0,000 0,09957555 0,10792826 ! lung development GO:0030324 94 59 0,000 0,09957555 0,10787742 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,09957555 0,10782663 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,09957555 0,10777589 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,10117764 0,1094584 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,10117764 0,10940694 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,10117764 0,10935553 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,10117764 0,10930416 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,10117764 0,10925285 ! regulation of heart contraction GO:0008016 91 60 0,000 0,10117764 0,10920158 ! fertilization GO:0009566 68 60 0,000 0,10117764 0,10915036 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,10117764 0,10909919 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,10277697 0,1107718 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,10277697 0,11071992 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,10277697 0,11066808 ! urogenital system development GO:0001655 101 61 0,000 0,10277697 0,11061629 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,10277697 0,11056456 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,10277697 0,11051287 ! extracellular matrix organization GO:0030198 103 61 0,000 0,10277697 0,11046122 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,10277697 0,11040963 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 0,000 0,10277697 0,11035809 ! amine catabolic process GO:0009310 90 62 0,000 0,10437354 0,11202013 ! neurotransmitter transport GO:0006836 81 62 0,000 0,10437354 0,11196788 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,10437354 0,11191568 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,10437354 0,11186353 ! respiratory tube development GO:0030323 99 62 0,000 0,10437354 0,11181143 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,10437354 0,11175938 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,10596736 0,11341319 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,10596736 0,11336044 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,10596736 0,11330773 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,10596736 0,11325508 ! viral reproduction GO:0016032 92 63 0,000 0,10596736 0,11320248 ! regulation of lipase activity GO:0060191 109 63 0,000 0,10596736 0,11314992 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,10755844 0,11479555 ! negative regulation of cell size GO:0045792 108 64 0,000 0,10755844 0,11474231 ! appendage morphogenesis GO:0035107 93 64 0,000 0,10755844 0,11468911 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,10755844 0,11463597 ! respiratory system development GO:0060541 100 64 0,000 0,10755844 0,11458287 ! adaptive immune response GO:0002250 94 64 0,000 0,10755844 0,11452982 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,10914678 0,11616733 ! regulation of caspase activity GO:0043281 97 65 0,000 0,10914678 0,1161136 ! appendage development GO:0048736 94 65 0,000 0,10914678 0,11605992 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,10914678 0,11600628 ! defense response to bacterium GO:0042742 73 65 0,000 0,10914678 0,1159527 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,10914678 0,11589917 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,10914678 0,11584568 ! activation of immune response GO:0002253 83 65 0,000 0,10914678 0,11579225 ! protein oligomerization GO:0051259 100 65 0,000 0,10914678 0,11573887 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,11073239 0,11736612 ! antigen processing and presentation GO:0019882 96 66 0,000 0,11073239 0,11731206 ! regulation of immune effector process GO:0002697 101 66 0,000 0,11073239 0,11725805 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,11231526 0,11887947 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,11231526 0,11882479 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,11231526 0,11877016 ! acute inflammatory response GO:0002526 92 68 0,000 0,1138954 0,12038577 ! learning or memory GO:0007611 123 68 0,000 0,1138954 0,12033047 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,1138954 0,12027522 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,1138954 0,12022002 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,1138954 0,12016487 ! rhythmic process GO:0048511 105 68 0,000 0,1138954 0,12010978 ! inorganic anion transport GO:0015698 93 68 0,000 0,1138954 0,12005473 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,11547283 0,1216617 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,11547283 0,121606 ! response to drug GO:0042493 108 69 0,000 0,11547283 0,12155034 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,11704753 0,12315156 ! humoral immune response GO:0006959 86 70 0,000 0,11704753 0,12309525 ! eye development GO:0001654 111 70 0,000 0,11704753 0,12303899 ! amine transport GO:0015837 101 70 0,000 0,11704753 0,12298279 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,11704753 0,12292663 ! regulation of catabolic process GO:0009894 106 70 0,000 0,11704753 0,12287052 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,11861952 0,12446392 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,11861952 0,12440716 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,11861952 0,12435046 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,11861952 0,1242938 ! regulation of peptidase activity GO:0052547 106 72 0,000 0,12018881 0,12588081 ! response to hypoxia GO:0001666 132 72 0,000 0,12018881 0,12582351 ! negative regulation of transport GO:0051051 116 73 0,000 0,12175539 0,12740554 ! regulation of blood pressure GO:0008217 107 73 0,000 0,12175539 0,12734761 ! mitochondrion organization GO:0007005 104 73 0,000 0,12175539 0,12728972 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,12175539 0,12723189 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,12175539 0,12717411 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,12331927 0,12874912 ! response to oxygen levels GO:0070482 137 74 0,000 0,12331927 0,1286907 ! digestion GO:0007586 97 74 0,000 0,12331927 0,12863234 ! protein import into nucleus GO:0006606 118 74 0,000 0,12331927 0,12857403 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,12331927 0,12851577 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,12331927 0,12845757 ! negative regulation of growth GO:0045926 123 75 0,000 0,12488045 0,13002491 ! response to nutrient GO:0007584 104 75 0,000 0,12488045 0,12996608 ! nuclear import GO:0051170 121 75 0,000 0,12488045 0,1299073 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,12488045 0,12984857 ! amine biosynthetic process GO:0009309 97 76 0,000 0,12643894 0,13140966 ! tRNA metabolic process GO:0006399 95 76 0,000 0,12643894 0,1313503 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,12643894 0,131291 ! regulation of protein transport GO:0051223 114 76 0,000 0,12643894 0,13123176 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,12799475 0,13278662 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,12799475 0,13272675 ! regulation of DNA binding GO:0051101 119 77 0,000 0,12799475 0,13266694 ! gland development GO:0048732 148 77 0,000 0,12799475 0,13260718 ! sex differentiation GO:0007548 105 77 0,000 0,12799475 0,13254747 ! protein ubiquitination GO:0016567 125 77 0,000 0,12799475 0,13248782 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,12799475 0,13242822 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,12954788 0,13397487 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,12954788 0,13391466 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,13109833 0,13545649 ! cellular respiration GO:0045333 107 79 0,000 0,13109833 0,13539567 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,13109833 0,1353349 ! T cell activation GO:0042110 134 79 0,000 0,13109833 0,13527418 ! regulation of lyase activity GO:0051339 133 79 0,000 0,13109833 0,13521352 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,13109833 0,13515291 ! chromatin assembly GO:0031497 102 80 0,000 0,1326461 0,13668729 GO:0006334|nucleosome assembly, ! protein localization in nucleus GO:0034504 133 80 0,000 0,1326461 0,13662608 ! forebrain development GO:0030900 131 80 0,000 0,1326461 0,13656492 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,13419121 0,13809386 ! mRNA transport GO:0051028 121 81 0,000 0,13419121 0,1380321 ! vitamin metabolic process GO:0006766 103 81 0,000 0,13419121 0,1379704 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,13419121 0,13790875 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,13573366 0,13943163 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,13573366 0,13936938 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,13727344 0,14088751 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,13727344 0,14082467 ! regulation of defense response GO:0031347 117 84 0,000 0,13881057 0,14233808 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,13881057 0,14227465 ! sterol metabolic process GO:0016125 120 84 0,000 0,13881057 0,14221128 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,14034505 0,14371933 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,14034505 0,14365537 ! rRNA metabolic process GO:0016072 107 85 0,000 0,14034505 0,14359147 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 0,000 0,14034505 0,14352762 ! transcription initiation GO:0006352 118 85 0,000 0,14034505 0,14346383 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,14034505 0,1434001 ! regulation of protein localization GO:0032880 132 85 0,000 0,14034505 0,14333642 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,14034505 0,1432728 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,14187688 0,14477233 ! nucleosome organization GO:0034728 114 87 0,000 0,14340607 0,14626784 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,14340607 0,146203 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,14340607 0,14613822 ! female pregnancy GO:0007565 130 87 0,000 0,14340607 0,1460735 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,14340607 0,14600884 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,14493263 0,14749781 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,14493263 0,14743257 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,14493263 0,14736739 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,14493263 0,14730227 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,14645655 0,14878536 ! reproductive developmental process GO:0003006 127 89 0,000 0,14645655 0,14871968 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,14645655 0,14865405 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,14645655 0,14858847 ! regulation of T cell activation GO:0050863 128 89 0,000 0,14645655 0,14852296 ! leukocyte differentiation GO:0002521 143 90 0,000 0,14797784 0,14999958 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,14797784 0,1499335 ! hormone metabolic process GO:0042445 121 90 0,000 0,14797784 0,14986748 ! ATP metabolic process GO:0046034 137 91 0,000 0,14949651 0,1513389 ! response to virus GO:0009615 122 91 0,000 0,14949651 0,15127232 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,15101256 0,15273918 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,15101256 0,15267204 ! cell fate commitment GO:0045165 141 92 0,000 0,15101256 0,15260496 ! positive regulation of immune response GO:0050778 121 92 0,000 0,15101256 0,15253794 ! DNA recombination GO:0006310 146 92 0,000 0,15101256 0,15247098 ! sulfur metabolic process GO:0006790 118 92 0,000 0,15101256 0,15240408 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,15252599 0,15386394 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,15252599 0,15379649 ! electron transport chain GO:0022900 123 94 0,000 0,15403682 0,15525183 ! response to oxidative stress GO:0006979 141 94 0,000 0,15403682 0,15518383 ! regulation of binding GO:0051098 151 95 0,000 0,15554503 0,15663467 ! angiogenesis GO:0001525 149 95 0,000 0,15554503 0,15656612 ! carboxylic acid transport GO:0046942 147 95 0,000 0,15554503 0,15649763 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,15705065 0,15794337 ! in utero embryonic development GO:0001701 147 96 0,000 0,15705065 0,15787434 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,15705065 0,15780537 ! protein maturation GO:0051604 129 96 0,000 0,15705065 0,15773646 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,15855366 0,15917653 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,15855366 0,15910708 ! calcium ion transport GO:0006816 167 99 0,000 0,16155192 0,1620451 ! extracellular structure organization GO:0043062 156 99 0,000 0,16155192 0,16197446 ! protein import GO:0017038 156 99 0,000 0,16155192 0,16190388 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,16304716 0,16333122 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,16304716 0,16326011 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,16304716 0,16318907 ! divalent metal ion transport GO:0070838 171 100 0,000 0,16304716 0,16311809 ! protein localization in organelle GO:0033365 161 100 0,000 0,16304716 0,16304716