pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a2/out-0.05-06-0.01-300-run-a2//th1-pval-1e-01-11-th2-pval-1e-02-02-th3-pval-1e-01-02-run-a2/go_data/11316-0-real-Van-De-Vijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! COPI coating of Golgi vesicle GO:0048205 8 8 2,000 8,642E-08 1,593E-04 GO:0048200|Golgi transport vesicle coating, ! Golgi vesicle budding GO:0048194 9 9 2,000 1,295E-07 1,194E-04 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 2,000 1,849E-07 1,136E-04 ! vesicle coating GO:0006901 10 10 2,000 1,849E-07 8,521E-05 ! membrane budding GO:0006900 11 11 2,000 2,541E-07 9,367E-05 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 2,000 5,595E-07 1,719E-04 ! vesicle targeting GO:0006903 17 16 2,000 8,597E-07 2,263E-04 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 2,000 8,597E-07 1,981E-04 ! regulation of microtubule-based process GO:0032886 18 18 2,000 1,251E-06 2,562E-04 ! establishment of vesicle localization GO:0051650 19 18 2,000 1,251E-06 2,306E-04 ! vesicle localization GO:0051648 20 19 2,000 1,485E-06 2,487E-04 ! vesicle organization GO:0016050 30 30 2,000 6,176E-06 9,485E-04 ! establishment of organelle localization GO:0051656 31 30 2,000 6,176E-06 8,755E-04 ! organelle localization GO:0051640 41 40 2,000 1,493E-05 1,966E-03 ! muscle cell migration GO:0014812 5 5 1,000 1,518E-05 1,865E-03 ! negative regulation of organelle organization GO:0010639 45 44 2,000 1,996E-05 2,299E-03 ! positive regulation of cell growth GO:0030307 6 6 1,000 2,276E-05 2,467E-03 ! ribosome assembly GO:0042255 6 6 1,000 2,276E-05 2,33E-03 ! thymus development GO:0048538 6 6 1,000 2,276E-05 2,208E-03 ! keratinocyte proliferation GO:0043616 7 7 1,000 3,184E-05 2,934E-03 ! induction of an organ GO:0001759 7 7 1,000 3,184E-05 2,794E-03 ! thyroid gland development GO:0030878 8 8 1,000 4,242E-05 3,554E-03 ! negative regulation of microtubule depolymerization GO:0007026 8 8 1,000 4,242E-05 3,399E-03 GO:0031114|regulation of microtubule depolymerization, ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 4,242E-05 3,258E-03 ! developmental induction GO:0031128 8 8 1,000 4,242E-05 3,127E-03 GO:0045168|cell-cell signaling involved in cell fate specification, ! positive regulation of cell size GO:0045793 9 9 1,000 5,451E-05 3,864E-03 ! negative regulation of caspase activity GO:0043154 9 9 1,000 5,451E-05 3,721E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 1,000 5,451E-05 3,588E-03 GO:0060675|ureteric bud morphogenesis, ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 1,000 5,451E-05 3,464E-03 ! negative regulation of cellular component organization GO:0051129 65 63 2,000 5,911E-05 3,631E-03 ! regulation of cytoskeleton organization GO:0051493 66 64 2,000 6,198E-05 3,685E-03 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 6,809E-05 3,921E-03 ! centrosome cycle GO:0007098 10 10 1,000 6,809E-05 3,803E-03 ! Golgi vesicle transport GO:0048193 67 67 2,000 7,112E-05 3,855E-03 ! skin development GO:0043588 11 11 1,000 8,316E-05 4,379E-03 ! negative regulation of peptidase activity GO:0010466 12 12 1,000 9,973E-05 5,105E-03 ! microtubule organizing center organization GO:0031023 12 12 1,000 9,973E-05 4,968E-03 GO:0051297|centrosome organization, ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 1,000 9,973E-05 4,837E-03 ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 1,000 1,178E-04 5,566E-03 ! ureteric bud development GO:0001657 13 13 1,000 1,178E-04 5,427E-03 ! cell aging GO:0007569 13 13 1,000 1,178E-04 5,294E-03 ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 1,000 1,178E-04 5,168E-03 ! inner ear morphogenesis GO:0042472 16 16 1,000 1,808E-04 7,75E-03 ! cell fate specification GO:0001708 16 16 1,000 1,808E-04 7,574E-03 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 1,000 2,048E-04 8,388E-03 ! embryonic skeletal system morphogenesis GO:0048704 17 17 1,000 2,048E-04 8,205E-03 ! anti-apoptosis GO:0006916 100 99 2,000 2,28E-04 8,941E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 1,000 2,302E-04 8,841E-03 ! metanephros development GO:0001656 19 19 1,000 2,572E-04 9,672E-03 ! ear morphogenesis GO:0042471 21 21 1,000 3,154E-04 0,01162496 ! negative regulation of hydrolase activity GO:0051346 21 21 1,000 3,154E-04 0,01139702 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 3,467E-04 0,01228729 GO:0090047|positive regulation of transcription regulator activity, ! embryonic skeletal system development GO:0048706 22 22 1,000 3,467E-04 0,01205545 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 1,000 3,467E-04 0,0118322 ! epithelial cell differentiation GO:0030855 23 23 1,000 3,794E-04 0,01271482 ! negative regulation of protein complex disassembly GO:0043242 23 23 1,000 3,794E-04 0,01248777 ! endocrine system development GO:0035270 23 23 1,000 3,794E-04 0,01226869 ! positive regulation of growth GO:0045927 23 23 1,000 3,794E-04 0,01205716 ! epithelial tube morphogenesis GO:0060562 25 24 1,000 4,137E-04 0,01292155 ! positive regulation of DNA binding GO:0043388 26 25 1,000 4,493E-04 0,0138017 ! positive regulation of binding GO:0051099 27 26 1,000 4,864E-04 0,01469675 ! induction of apoptosis by intracellular signals GO:0008629 26 26 1,000 4,864E-04 0,01445971 ! inner ear development GO:0048839 27 27 1,000 5,25E-04 0,01535817 ! keratinocyte differentiation GO:0030216 28 28 1,000 5,65E-04 0,01627008 ! branching morphogenesis of a tube GO:0048754 29 29 1,000 6,064E-04 0,01719474 ! regulation of protein complex disassembly GO:0043244 30 30 1,000 6,493E-04 0,01813148 ! skeletal system morphogenesis GO:0048705 31 30 1,000 6,493E-04 0,01786086 ! skeletal muscle fiber development GO:0048741 31 31 1,000 6,936E-04 0,0187991 ! negative regulation of cytoskeleton organization GO:0051494 32 31 1,000 6,936E-04 0,01852665 ! aging GO:0007568 32 31 1,000 6,936E-04 0,01826198 ! ribonucleoprotein complex assembly GO:0022618 32 31 1,000 6,936E-04 0,01800477 ! epidermal cell differentiation GO:0009913 31 31 1,000 6,936E-04 0,01775471 ! muscle fiber development GO:0048747 32 32 1,000 7,394E-04 0,01866624 ! morphogenesis of a branching structure GO:0001763 32 32 1,000 7,394E-04 0,018414 ! kidney development GO:0001822 32 32 1,000 7,394E-04 0,01816848 ! regulation of neuron differentiation GO:0045664 34 33 1,000 7,865E-04 0,01907319 ! ear development GO:0043583 34 34 1,000 8,351E-04 0,0199885 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 1,000 8,851E-04 0,02091392 ! regulation of transcription factor activity GO:0051090 38 37 1,000 9,894E-04 0,02308183 GO:0090046|regulation of transcription regulator activity, ! negative regulation of protein kinase activity GO:0006469 37 37 1,000 9,894E-04 0,02279331 ! DNA damage response, signal transduction GO:0042770 37 37 1,000 9,894E-04 0,02251191 ! negative regulation of kinase activity GO:0033673 38 38 1,000 1,044E-03 0,02345684 ! urogenital system development GO:0001655 38 38 1,000 1,044E-03 0,02317423 ! negative regulation of transferase activity GO:0051348 40 40 1,000 1,156E-03 0,02537192 ! regulation of caspase activity GO:0043281 41 41 1,000 1,215E-03 0,02634135 ! regulation of endopeptidase activity GO:0052548 42 42 1,000 1,275E-03 0,02731824 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 1,000 1,275E-03 0,02700424 ! mitochondrion organization GO:0007005 44 43 1,000 1,336E-03 0,02798067 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 1,000 1,399E-03 0,02896403 ! regulation of DNA binding GO:0051101 47 45 1,000 1,463E-03 0,02995405 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 1,000 1,463E-03 0,02962488 ! tube morphogenesis GO:0035239 47 46 1,000 1,528E-03 0,03061402 ! regulation of peptidase activity GO:0052547 46 46 1,000 1,528E-03 0,03028483 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 1,000 1,528E-03 0,02996265 ! positive regulation of ligase activity GO:0051351 47 46 1,000 1,528E-03 0,02964726 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 1,000 1,663E-03 0,03193122 ! regulation of cell cycle process GO:0010564 50 48 1,000 1,663E-03 0,03160203 ! gland development GO:0048732 51 49 1,000 1,733E-03 0,03258846 ! skeletal muscle tissue development GO:0007519 50 49 1,000 1,733E-03 0,03225928 GO:0060538|skeletal muscle organ development, ! regulation of ligase activity GO:0051340 50 49 1,000 1,733E-03 0,03193669 ! chromatin assembly GO:0031497 50 50 1,000 1,804E-03 0,03291563 GO:0006334|nucleosome assembly, ! regulation of neurogenesis GO:0050767 51 50 1,000 1,804E-03 0,03259293 ! protein-DNA complex assembly GO:0065004 51 51 1,000 1,876E-03 0,03357108 ! cell fate commitment GO:0045165 52 52 1,000 1,95E-03 0,03455473 ! nucleosome organization GO:0034728 55 55 1,000 2,179E-03 0,03825155 ! microtubule cytoskeleton organization GO:0000226 55 55 1,000 2,179E-03 0,03789069 ! regulation of nervous system development GO:0051960 57 56 1,000 2,258E-03 0,03890037 ! regulation of binding GO:0051098 60 57 1,000 2,339E-03 0,03991451 ! regulation of cell development GO:0060284 60 59 1,000 2,504E-03 0,04234039 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 1,000 2,589E-03 0,04337273 ! proteasomal protein catabolic process GO:0010498 62 61 1,000 2,675E-03 0,04440881 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! morphogenesis of an epithelium GO:0002009 63 62 1,000 2,762E-03 0,04544848 GO:0060429|epithelium development, ! DNA packaging GO:0006323 66 66 1,000 3,124E-03 0,05095819 ! negative regulation of protein metabolic process GO:0051248 66 66 1,000 3,124E-03 0,05051119 ! striated muscle tissue development GO:0014706 69 67 1,000 3,218E-03 0,05157756 ! chromatin assembly or disassembly GO:0006333 68 68 1,000 3,314E-03 0,05264661 ! regulation of cell size GO:0008361 68 68 1,000 3,314E-03 0,05219664 ! sensory perception of sound GO:0007605 71 69 1,000 3,41E-03 0,05326299 GO:0050954|sensory perception of mechanical stimulus, ! muscle tissue development GO:0060537 72 70 1,000 3,508E-03 0,05433185 ! ribosome biogenesis GO:0042254 71 71 1,000 3,607E-03 0,05540312 ! negative regulation of signal transduction GO:0009968 71 71 1,000 3,607E-03 0,05494524 ! sensory organ development GO:0007423 72 72 1,000 3,708E-03 0,05601377 ! negative regulation of cell communication GO:0010648 76 76 1,000 4,123E-03 0,06178066 ! nuclear transport GO:0051169 79 79 1,000 4,448E-03 0,06611454 GO:0006913|nucleocytoplasmic transport, ! tube development GO:0035295 83 81 1,000 4,671E-03 0,06887655 ! DNA replication GO:0006260 91 91 1,000 5,864E-03 0,08577614 ! tissue morphogenesis GO:0048729 94 93 1,000 6,118E-03 0,08878293 ! pattern specification process GO:0007389 96 94 1,000 6,247E-03 0,0899431 ! epidermis development GO:0008544 94 94 1,000 6,247E-03 0,08924587 ! regulation of cell growth GO:0001558 97 96 1,000 6,508E-03 0,09226304 ! rRNA transcription GO:0009303 5 5 0,000 6,526E-03 0,09180532 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 6,526E-03 0,09110982 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 6,526E-03 0,09042479 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 6,526E-03 0,08974997 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 6,526E-03 0,08908516 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 6,526E-03 0,08843012 ! reproductive cellular process GO:0048610 5 5 0,000 6,526E-03 0,08778465 ! positive regulation of glucose metabolic process GO:0010907 5 5 0,000 6,526E-03 0,08714853 ! negative regulation of blood pressure GO:0045776 6 5 0,000 6,526E-03 0,08652156 ! prostate gland development GO:0030850 5 5 0,000 6,526E-03 0,08590355 ! metencephalon development GO:0022037 5 5 0,000 6,526E-03 0,0852943 ! water transport GO:0006833 5 5 0,000 6,526E-03 0,08469364 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 6,526E-03 0,08410137 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 6,526E-03 0,08351734 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 6,526E-03 0,08294136 ! glycerol metabolic process GO:0006071 5 5 0,000 6,526E-03 0,08237326 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 6,526E-03 0,0818129 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 6,526E-03 0,08126011 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 6,526E-03 0,08071474 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 6,526E-03 0,08017664 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 6,526E-03 0,07964567 ! filopodium assembly GO:0046847 7 5 0,000 6,526E-03 0,07912169 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 6,526E-03 0,07860455 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 6,526E-03 0,07809413 ! GTP metabolic process GO:0046039 5 5 0,000 6,526E-03 0,0775903 ! establishment of tissue polarity GO:0007164 5 5 0,000 6,526E-03 0,07709293 ! mRNA stabilization GO:0048255 5 5 0,000 6,526E-03 0,07660189 GO:0043489|RNA stabilization, ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 6,526E-03 0,07611707 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 6,526E-03 0,07563834 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 6,526E-03 0,0751656 ! social behavior GO:0035176 5 5 0,000 6,526E-03 0,07469874 ! macrophage chemotaxis GO:0048246 6 5 0,000 6,526E-03 0,07423763 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 6,526E-03 0,07378219 ! memory GO:0007613 5 5 0,000 6,526E-03 0,0733323 ! dopamine receptor signaling pathway GO:0007212 5 5 0,000 6,526E-03 0,07288786 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 6,526E-03 0,07244877 ! membrane hyperpolarization GO:0060081 5 5 0,000 6,526E-03 0,07201495 ! response to lipid GO:0033993 5 5 0,000 6,526E-03 0,07158629 ! erythrocyte maturation GO:0043249 5 5 0,000 6,526E-03 0,0711627 ! hippocampus development GO:0021766 6 5 0,000 6,526E-03 0,0707441 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 6,526E-03 0,07033039 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 6,526E-03 0,06992149 ! middle ear morphogenesis GO:0042474 5 5 0,000 6,526E-03 0,06951732 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 6,526E-03 0,0691178 ! mechanosensory behavior GO:0007638 5 5 0,000 6,526E-03 0,06872284 ! heart looping GO:0001947 5 5 0,000 6,526E-03 0,06833237 ! negative regulation of endocytosis GO:0045806 5 5 0,000 6,526E-03 0,06794631 ! response to interferon-gamma GO:0034341 5 5 0,000 6,526E-03 0,06756459 ! pseudouridine synthesis GO:0001522 5 5 0,000 6,526E-03 0,06718713 ! endocrine pancreas development GO:0031018 5 5 0,000 6,526E-03 0,06681387 ! pH reduction GO:0045851 5 5 0,000 6,526E-03 0,06644473 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 6,526E-03 0,06607965 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 6,526E-03 0,06571856 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 6,526E-03 0,06536139 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 6,526E-03 0,06500809 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 6,526E-03 0,06465858 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 6,526E-03 0,06431282 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 6,526E-03 0,06397073 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 6,526E-03 0,06363226 ! adrenal gland development GO:0030325 5 5 0,000 6,526E-03 0,06329735 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 6,526E-03 0,06296595 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 6,526E-03 0,062638 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 6,526E-03 0,06231345 ! astrocyte differentiation GO:0048708 5 5 0,000 6,526E-03 0,06199225 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 6,526E-03 0,06167434 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 6,526E-03 0,06135968 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 6,526E-03 0,06104821 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 6,526E-03 0,06073988 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 6,526E-03 0,06043466 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 6,526E-03 0,06013248 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 6,526E-03 0,05983332 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 6,526E-03 0,05953711 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 6,526E-03 0,05924383 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 6,526E-03 0,05895341 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! phasic smooth muscle contraction GO:0014821 5 5 0,000 6,526E-03 0,05866584 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 6,526E-03 0,05838105 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 6,526E-03 0,05809902 ! response to ATP GO:0033198 5 5 0,000 6,526E-03 0,05781969 ! regulation of type I interferon production GO:0032479 5 5 0,000 6,526E-03 0,05754305 ! regulation of appetite GO:0032098 5 5 0,000 6,526E-03 0,05726903 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 6,526E-03 0,05699761 ! paraxial mesoderm development GO:0048339 5 5 0,000 6,526E-03 0,05672876 ! regulation of phospholipase A2 activity GO:0032429 5 5 0,000 6,526E-03 0,05646243 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 6,526E-03 0,05619858 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 6,526E-03 0,05593719 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 6,526E-03 0,05567822 ! receptor clustering GO:0043113 5 5 0,000 6,526E-03 0,05542164 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 6,526E-03 0,05516742 ! fear response GO:0042596 5 5 0,000 6,526E-03 0,05491551 ! actin cytoskeleton reorganization GO:0031532 5 5 0,000 6,526E-03 0,05466589 ! lens development in camera-type eye GO:0002088 5 5 0,000 6,526E-03 0,05441854 ! retinol metabolic process GO:0042572 5 5 0,000 6,526E-03 0,05417341 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 6,526E-03 0,05393048 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 6,526E-03 0,05368972 ! positive regulation of exocytosis GO:0045921 6 5 0,000 6,526E-03 0,0534511 ! parturition GO:0007567 5 5 0,000 6,526E-03 0,05321459 ! cellular glucose homeostasis GO:0001678 5 5 0,000 6,526E-03 0,05298016 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 0,000 6,526E-03 0,05274779 ! Schwann cell differentiation GO:0014037 5 5 0,000 6,526E-03 0,05251745 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 6,526E-03 0,05228912 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 6,526E-03 0,05206276 ! protein heterooligomerization GO:0051291 5 5 0,000 6,526E-03 0,05183835 ! regulation of gliogenesis GO:0014013 5 5 0,000 6,526E-03 0,05161586 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 6,526E-03 0,05139528 ! response to UV-B GO:0010224 5 5 0,000 6,526E-03 0,05117658 ! oligodendrocyte development GO:0014003 5 5 0,000 6,526E-03 0,05095973 ! hyaluronan metabolic process GO:0030212 5 5 0,000 6,526E-03 0,05074471 ! activated T cell proliferation GO:0050798 5 5 0,000 6,526E-03 0,0505315 ! interaction with symbiont GO:0051702 5 5 0,000 6,526E-03 0,05032007 ! cellular extravasation GO:0045123 5 5 0,000 6,526E-03 0,0501104 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 6,526E-03 0,04990248 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 6,526E-03 0,04969627 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 6,526E-03 0,04949176 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 6,526E-03 0,04928892 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 6,526E-03 0,04908774 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 6,526E-03 0,0488882 ! response to amine stimulus GO:0014075 5 5 0,000 6,526E-03 0,04869027 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 6,526E-03 0,04849394 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 6,526E-03 0,04829918 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 6,526E-03 0,04810599 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 6,526E-03 0,04791433 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 6,526E-03 0,04772419 ! neuron recognition GO:0008038 5 5 0,000 6,526E-03 0,04753556 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 6,526E-03 0,04734841 ! decidualization GO:0046697 5 5 0,000 6,526E-03 0,04716273 ! hair follicle maturation GO:0048820 5 5 0,000 6,526E-03 0,0469785 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 6,526E-03 0,04679571 ! regulation of mitochondrial membrane potential GO:0051881 5 5 0,000 6,526E-03 0,04661433 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 6,526E-03 0,04643435 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 6,526E-03 0,04625576 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 6,526E-03 0,04607853 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 6,526E-03 0,04590266 ! postreplication repair GO:0006301 5 5 0,000 6,526E-03 0,04572812 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 6,526E-03 0,04555491 GO:0021517|ventral spinal cord development, ! cellular pigmentation GO:0033059 5 5 0,000 6,526E-03 0,04538301 ! histone methylation GO:0016571 5 5 0,000 6,526E-03 0,04521239 ! DNA methylation GO:0006306 5 5 0,000 6,526E-03 0,04504306 GO:0006305|DNA alkylation, ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 6,526E-03 0,04487499 ! T cell lineage commitment GO:0002360 5 5 0,000 6,526E-03 0,04470817 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 6,526E-03 0,04454258 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 6,526E-03 0,04437822 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 6,526E-03 0,04421506 ! intracellular cholesterol transport GO:0032367 5 5 0,000 6,526E-03 0,0440531 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 6,526E-03 0,04389232 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 6,526E-03 0,04373271 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 6,526E-03 0,04357426 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 6,526E-03 0,04341695 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 6,526E-03 0,04326078 ! sterol catabolic process GO:0016127 5 5 0,000 6,526E-03 0,04310572 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 6,526E-03 0,04295177 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 6,526E-03 0,04279892 ! detection of biotic stimulus GO:0009595 5 5 0,000 6,526E-03 0,04264715 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 6,526E-03 0,04249645 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 6,526E-03 0,04234682 ! zymogen activation GO:0031638 5 5 0,000 6,526E-03 0,04219823 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 6,526E-03 0,04205069 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 6,526E-03 0,04190417 GO:0002820|negative regulation of adaptive immune response, ! cellular response to nutrient GO:0031670 5 5 0,000 6,526E-03 0,04175867 ! peptidyl-lysine modification GO:0018205 5 5 0,000 6,526E-03 0,04161417 ! negative regulation of neuroblast proliferation GO:0007406 5 5 0,000 6,526E-03 0,04147068 ! peptidyl-histidine modification GO:0018202 5 5 0,000 6,526E-03 0,04132817 ! nucleosome positioning GO:0016584 5 5 0,000 6,526E-03 0,04118663 ! regulation of isotype switching GO:0045191 5 5 0,000 6,526E-03 0,04104606 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 6,526E-03 0,04090645 ! negative regulation of neurological system process GO:0031645 5 5 0,000 6,526E-03 0,04076778 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 6,526E-03 0,04063006 ! glutathione biosynthetic process GO:0006750 5 5 0,000 6,526E-03 0,04049325 ! NADPH regeneration GO:0006740 5 5 0,000 6,526E-03 0,04035737 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 6,526E-03 0,0402224 ! positive regulation of epidermis development GO:0045684 5 5 0,000 6,526E-03 0,04008832 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 0,000 6,526E-03 0,03995514 GO:0002688|regulation of leukocyte chemotaxis, ! musculoskeletal movement GO:0050881 5 5 0,000 6,526E-03 0,03982284 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 6,526E-03 0,03969141 ! sarcomere organization GO:0045214 5 5 0,000 6,526E-03 0,03956084 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 6,526E-03 0,03943114 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 6,526E-03 0,03930228 ! negative regulation of glucose transport GO:0010829 5 5 0,000 6,526E-03 0,03917426 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 6,526E-03 0,03904707 GO:0045622|regulation of T-helper cell differentiation, ! oocyte differentiation GO:0009994 5 5 0,000 6,526E-03 0,0389207 GO:0048599|oocyte development, ! dopamine biosynthetic process GO:0042416 5 5 0,000 6,526E-03 0,03879515 ! regulation of protein homodimerization activity GO:0043496 6 5 0,000 6,526E-03 0,03867041 ! spleen development GO:0048536 5 5 0,000 6,526E-03 0,03854646 ! male genitalia development GO:0030539 5 5 0,000 6,526E-03 0,03842331 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 6,526E-03 0,03830094 ! quaternary ammonium group transport GO:0015697 5 5 0,000 6,526E-03 0,03817935 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 6,526E-03 0,03805853 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 6,526E-03 0,03793847 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 6,526E-03 0,03781917 ! removal of superoxide radicals GO:0019430 6 5 0,000 6,526E-03 0,03770062 ! myeloid cell homeostasis GO:0002262 5 5 0,000 6,526E-03 0,0375828 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 6,526E-03 0,03746572 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 6,526E-03 0,03734937 ! ATP catabolic process GO:0006200 5 5 0,000 6,526E-03 0,03723374 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 6,526E-03 0,03711882 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 6,526E-03 0,0370046 ! blastocyst formation GO:0001825 5 5 0,000 6,526E-03 0,03689109 ! regulation of fibrinolysis GO:0051917 5 5 0,000 6,526E-03 0,03677828 ! embryonic gut development GO:0048566 5 5 0,000 6,526E-03 0,03666615 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 6,526E-03 0,0365547 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 6,526E-03 0,03644393 ! activation of innate immune response GO:0002218 5 5 0,000 6,526E-03 0,03633383 GO:0002758|innate immune response-activating signal transduction, ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 0,000 6,526E-03 0,03622439 ! catecholamine transport GO:0051937 5 5 0,000 6,526E-03 0,03611561 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 6,526E-03 0,03600747 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 6,526E-03 0,03589999 ! muscle adaptation GO:0043500 5 5 0,000 6,526E-03 0,03579314 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 6,526E-03 0,03568693 ! embryonic heart tube development GO:0035050 5 5 0,000 6,526E-03 0,03558135 ! cardiac cell differentiation GO:0035051 6 5 0,000 6,526E-03 0,03547639 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 6,526E-03 0,03537205 ! defense response to fungus GO:0050832 5 5 0,000 6,526E-03 0,03526832 ! lysogeny GO:0030069 5 5 0,000 6,526E-03 0,03516519 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 6,526E-03 0,03506267 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 6,526E-03 0,03496075 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 6,526E-03 0,03485941 ! response to nicotine GO:0035094 5 5 0,000 6,526E-03 0,03475866 ! establishment of cell polarity GO:0030010 5 5 0,000 6,526E-03 0,03465849 ! mitochondrion localization GO:0051646 5 5 0,000 6,526E-03 0,0345589 ! nucleus localization GO:0051647 5 5 0,000 6,526E-03 0,03445988 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 6,526E-03 0,03436142 ! ectoderm development GO:0007398 99 99 1,000 6,909E-03 0,03627807 ! muscle organ development GO:0007517 102 100 1,000 7,045E-03 0,03688817 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 7,826E-03 0,04085951 ! axon extension GO:0048675 7 6 0,000 7,826E-03 0,04074409 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 7,826E-03 0,04062932 ! N-terminal protein amino acid modification GO:0031365 6 6 0,000 7,826E-03 0,04051519 GO:0018409|peptide or protein amino-terminal blocking, ! tRNA modification GO:0006400 6 6 0,000 7,826E-03 0,0404017 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 7,826E-03 0,04028885 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 7,826E-03 0,04017662 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 7,826E-03 0,04006502 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 7,826E-03 0,03995404 ! virus-host interaction GO:0019048 6 6 0,000 7,826E-03 0,03984367 ! regulation of S phase GO:0033261 6 6 0,000 7,826E-03 0,0397339 ! myotube differentiation GO:0014902 6 6 0,000 7,826E-03 0,03962475 ! regulation of B cell proliferation GO:0030888 6 6 0,000 7,826E-03 0,03951618 ! bone remodeling GO:0046849 6 6 0,000 7,826E-03 0,03940822 ! N-glycan processing GO:0006491 6 6 0,000 7,826E-03 0,03930084 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 7,826E-03 0,03919404 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 7,826E-03 0,03908782 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 7,826E-03 0,03898218 ! retina development in camera-type eye GO:0060041 6 6 0,000 7,826E-03 0,03887711 ! RNA methylation GO:0001510 6 6 0,000 7,826E-03 0,0387726 ! cartilage condensation GO:0001502 7 6 0,000 7,826E-03 0,03866865 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 7,826E-03 0,03856526 ! regulation of positive chemotaxis GO:0050926 6 6 0,000 7,826E-03 0,03846242 GO:0050927|positive regulation of positive chemotaxis, ! succinate metabolic process GO:0006105 7 6 0,000 7,826E-03 0,03836013 ! artery development GO:0060840 6 6 0,000 7,826E-03 0,03825837 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 7,826E-03 0,03815716 ! bile acid metabolic process GO:0008206 6 6 0,000 7,826E-03 0,03805648 ! androgen metabolic process GO:0008209 6 6 0,000 7,826E-03 0,03795633 ! estrogen metabolic process GO:0008210 6 6 0,000 7,826E-03 0,03785671 ! limbic system development GO:0021761 7 6 0,000 7,826E-03 0,03775761 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 7,826E-03 0,03765903 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 0,000 7,826E-03 0,03756096 ! positive regulation of heart contraction GO:0045823 6 6 0,000 7,826E-03 0,0374634 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 7,826E-03 0,03736634 ! pathogenesis GO:0009405 6 6 0,000 7,826E-03 0,03726979 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 7,826E-03 0,03717373 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 7,826E-03 0,03707817 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 7,826E-03 0,0369831 ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 7,826E-03 0,03688851 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 7,826E-03 0,03679441 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 7,826E-03 0,03670078 ! arginine metabolic process GO:0006525 6 6 0,000 7,826E-03 0,03660763 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 7,826E-03 0,03651496 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 7,826E-03 0,03642275 ! glutamate catabolic process GO:0006538 7 6 0,000 7,826E-03 0,036331 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 7,826E-03 0,03623972 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 7,826E-03 0,03614889 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 7,826E-03 0,03605852 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 6 6 0,000 7,826E-03 0,0359686 ! ER overload response GO:0006983 6 6 0,000 7,826E-03 0,03587912 ! V(D)J recombination GO:0033151 6 6 0,000 7,826E-03 0,03579009 ! focal adhesion formation GO:0048041 7 6 0,000 7,826E-03 0,0357015 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 7,826E-03 0,03561335 ! negative regulation of T cell proliferation GO:0042130 6 6 0,000 7,826E-03 0,03552563 GO:0070667|negative regulation of mast cell proliferation, ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 7,826E-03 0,03543835 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 7,826E-03 0,03535149 ! regulation of heart rate GO:0002027 6 6 0,000 7,826E-03 0,03526505 ! lipid digestion GO:0044241 6 6 0,000 7,826E-03 0,03517904 ! asymmetric protein localization GO:0008105 6 6 0,000 7,826E-03 0,03509345 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 7,826E-03 0,03500827 ! phagocytosis, engulfment GO:0006911 6 6 0,000 7,826E-03 0,0349235 ! Rac protein signal transduction GO:0016601 6 6 0,000 7,826E-03 0,03483915 ! regulation of vascular permeability GO:0043114 6 6 0,000 7,826E-03 0,0347552 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 7,826E-03 0,03467165 ! ruffle organization GO:0031529 6 6 0,000 7,826E-03 0,03458851 ! peptidyl-serine phosphorylation GO:0018105 6 6 0,000 7,826E-03 0,03450576 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 7,826E-03 0,03442341 ! retinoic acid metabolic process GO:0042573 6 6 0,000 7,826E-03 0,03434145 ! neutral amino acid transport GO:0015804 6 6 0,000 7,826E-03 0,03425987 ! L-amino acid transport GO:0015807 6 6 0,000 7,826E-03 0,03417869 ! bone mineralization GO:0030282 6 6 0,000 7,826E-03 0,03409789 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 7,826E-03 0,03401747 ! negative regulation of ossification GO:0030279 6 6 0,000 7,826E-03 0,03393743 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 7,826E-03 0,03385776 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of bone resorption GO:0045124 6 6 0,000 7,826E-03 0,03377847 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 7,826E-03 0,03369955 ! purine base biosynthetic process GO:0009113 6 6 0,000 7,826E-03 0,033621 ! G1 DNA damage checkpoint GO:0031571 6 6 0,000 7,826E-03 0,03354281 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 7,826E-03 0,03346498 ! regulation of phagocytosis GO:0050764 6 6 0,000 7,826E-03 0,03338752 ! regulation of organ growth GO:0046620 6 6 0,000 7,826E-03 0,03331041 ! regulation of circadian rhythm GO:0042752 6 6 0,000 7,826E-03 0,03323366 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 7,826E-03 0,03315726 ! response to dsRNA GO:0043331 6 6 0,000 7,826E-03 0,03308121 ! DNA unwinding during replication GO:0006268 6 6 0,000 7,826E-03 0,03300551 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 7,826E-03 0,03293015 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! regulation of T cell differentiation in the thymus GO:0033081 6 6 0,000 7,826E-03 0,03285514 ! genitalia development GO:0048806 6 6 0,000 7,826E-03 0,03278047 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 7,826E-03 0,03270614 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 7,826E-03 0,03263214 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 0,000 7,826E-03 0,03255848 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 7,826E-03 0,03248515 ! multicellular organismal aging GO:0010259 6 6 0,000 7,826E-03 0,03241215 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 7,826E-03 0,03233948 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 7,826E-03 0,03226713 ! erythrocyte development GO:0048821 6 6 0,000 7,826E-03 0,03219511 ! renal water homeostasis GO:0003091 6 6 0,000 7,826E-03 0,0321234 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 7,826E-03 0,03205202 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 7,826E-03 0,03198095 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 7,826E-03 0,03191019 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 7,826E-03 0,03183975 ! diencephalon development GO:0021536 6 6 0,000 7,826E-03 0,03176962 ! fucose catabolic process GO:0019317 6 6 0,000 7,826E-03 0,0316998 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 7,826E-03 0,03163028 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 0,000 7,826E-03 0,03156107 ! regulation of lipid transport GO:0032368 6 6 0,000 7,826E-03 0,03149216 ! regulation of cell division GO:0051302 6 6 0,000 7,826E-03 0,03142355 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 7,826E-03 0,03135523 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 7,826E-03 0,03128722 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 7,826E-03 0,0312195 ! salivary gland morphogenesis GO:0007435 6 6 0,000 7,826E-03 0,03115207 ! neuroblast proliferation GO:0007405 6 6 0,000 7,826E-03 0,03108493 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 7,826E-03 0,03101808 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 7,826E-03 0,03095152 ! regulation of glucose transport GO:0010827 6 6 0,000 7,826E-03 0,03088524 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 7,826E-03 0,03081925 ! methionine biosynthetic process GO:0009086 6 6 0,000 7,826E-03 0,03075353 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 7,826E-03 0,0306881 ! serine family amino acid biosynthetic process GO:0009070 6 6 0,000 7,826E-03 0,03062295 ! lymph node development GO:0048535 6 6 0,000 7,826E-03 0,03055807 ! organic cation transport GO:0015695 6 6 0,000 7,826E-03 0,03049346 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 7,826E-03 0,03042913 ! regulation of RNA splicing GO:0043484 6 6 0,000 7,826E-03 0,03036507 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 0,000 7,826E-03 0,03030128 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! positive regulation of JNK cascade GO:0046330 7 6 0,000 7,826E-03 0,03023775 ! sperm-egg recognition GO:0035036 7 6 0,000 7,826E-03 0,03017449 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 7,826E-03 0,0301115 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 7,826E-03 0,03004877 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 7,826E-03 0,02998629 ! alditol metabolic process GO:0019400 6 6 0,000 7,826E-03 0,02992408 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 7,826E-03 0,02986213 ! regulation of amino acid transport GO:0051955 6 6 0,000 7,826E-03 0,02980043 ! maternal placenta development GO:0001893 6 6 0,000 7,826E-03 0,02973898 ! regulation of embryonic development GO:0045995 6 6 0,000 7,826E-03 0,02967779 ! negative regulation of immune effector process GO:0002698 6 6 0,000 7,826E-03 0,02961685 ! localization within membrane GO:0051668 6 6 0,000 7,826E-03 0,02955616 ! respiratory burst GO:0045730 7 7 0,000 9,125E-03 0,03439167 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 9,125E-03 0,03432149 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 0,000 9,125E-03 0,03425159 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 9,125E-03 0,03418197 ! positive regulation of blood pressure GO:0045777 7 7 0,000 9,125E-03 0,03411263 ! positive regulation of cellular catabolic process GO:0031331 7 7 0,000 9,125E-03 0,03404358 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 9,125E-03 0,03397481 ! regulation of chemokine production GO:0032642 7 7 0,000 9,125E-03 0,03390631 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 9,125E-03 0,03383809 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 9,125E-03 0,03377014 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 9,125E-03 0,03370246 ! cellular protein complex disassembly GO:0043624 8 7 0,000 9,125E-03 0,03363506 GO:0043241|protein complex disassembly, ! hair follicle morphogenesis GO:0031069 7 7 0,000 9,125E-03 0,03356792 ! gene silencing by RNA GO:0031047 7 7 0,000 9,125E-03 0,03350105 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 9,125E-03 0,03343445 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 9,125E-03 0,03336811 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 9,125E-03 0,03330204 ! axis specification GO:0009798 7 7 0,000 9,125E-03 0,03323622 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 9,125E-03 0,03317067 ! visual behavior GO:0007632 7 7 0,000 9,125E-03 0,03310537 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 9,125E-03 0,03304033 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 9,125E-03 0,03297555 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 9,125E-03 0,03291101 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 9,125E-03 0,03284674 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 9,125E-03 0,03278271 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 9,125E-03 0,03271893 ! endothelial cell differentiation GO:0045446 7 7 0,000 9,125E-03 0,0326554 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 9,125E-03 0,03259211 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 9,125E-03 0,03252907 ! digestive system development GO:0055123 7 7 0,000 9,125E-03 0,03246627 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! hemoglobin metabolic process GO:0020027 7 7 0,000 9,125E-03 0,03240372 ! regulation of exit from mitosis GO:0007096 7 7 0,000 9,125E-03 0,0323414 ! protein targeting to ER GO:0045047 8 7 0,000 9,125E-03 0,03227933 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 9,125E-03 0,03221749 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 9,125E-03 0,03215589 ! endoderm development GO:0007492 7 7 0,000 9,125E-03 0,03209452 ! regulation of defense response to virus GO:0050688 7 7 0,000 9,125E-03 0,03203339 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 9,125E-03 0,03197249 GO:0006688|glycosphingolipid biosynthetic process, ! regulation of mRNA processing GO:0050684 7 7 0,000 9,125E-03 0,03191182 ! response to hexose stimulus GO:0009746 7 7 0,000 9,125E-03 0,03185138 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 9,125E-03 0,03179117 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 9,125E-03 0,03173119 ! regulation of skeletal muscle fiber development GO:0048742 7 7 0,000 9,125E-03 0,03167143 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 0,000 9,125E-03 0,0316119 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! cardiac muscle tissue development GO:0048738 7 7 0,000 9,125E-03 0,03155259 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 9,125E-03 0,0314935 ! complement activation, alternative pathway GO:0006957 7 7 0,000 9,125E-03 0,03143463 ! arachidonic acid secretion GO:0050482 7 7 0,000 9,125E-03 0,03137599 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 9,125E-03 0,03131756 ! response to X-ray GO:0010165 7 7 0,000 9,125E-03 0,03125935 ! regulation of intracellular pH GO:0051453 7 7 0,000 9,125E-03 0,03120135 ! UV protection GO:0009650 7 7 0,000 9,125E-03 0,03114357 ! DNA integration GO:0015074 7 7 0,000 9,125E-03 0,031086 ! myofibril assembly GO:0030239 7 7 0,000 9,125E-03 0,03102865 GO:0055002|striated muscle cell development, ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 0,000 9,125E-03 0,03097151 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 9,125E-03 0,03091457 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 9,125E-03 0,03085785 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 9,125E-03 0,03080133 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 9,125E-03 0,03074502 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 9,125E-03 0,03068892 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 9,125E-03 0,03063302 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 9,125E-03 0,03057732 GO:0019827|stem cell maintenance, ! alpha-beta T cell differentiation GO:0046632 7 7 0,000 9,125E-03 0,03052183 ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 9,125E-03 0,03046654 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 9,125E-03 0,03041144 ! axon cargo transport GO:0008088 7 7 0,000 9,125E-03 0,03035655 ! eating behavior GO:0042755 7 7 0,000 9,125E-03 0,03030185 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 9,125E-03 0,03024735 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 9,125E-03 0,03019305 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 9,125E-03 0,03013894 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 9,125E-03 0,03008502 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 9,125E-03 0,0300313 ! cranial nerve development GO:0021545 7 7 0,000 9,125E-03 0,02997777 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 9,125E-03 0,02992443 ! leukocyte activation during immune response GO:0002366 7 7 0,000 9,125E-03 0,02987128 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 9,125E-03 0,02981831 ! autonomic nervous system development GO:0048483 7 7 0,000 9,125E-03 0,02976554 ! intracellular lipid transport GO:0032365 7 7 0,000 9,125E-03 0,02971295 ! detection of chemical stimulus GO:0009593 8 7 0,000 9,125E-03 0,02966054 ! platelet activation GO:0030168 8 7 0,000 9,125E-03 0,02960832 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 9,125E-03 0,02955629 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 9,125E-03 0,02950444 ! natural killer cell activation GO:0030101 7 7 0,000 9,125E-03 0,02945276 ! response to gamma radiation GO:0010332 8 7 0,000 9,125E-03 0,02940127 ! NADP metabolic process GO:0006739 7 7 0,000 9,125E-03 0,02934996 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 9,125E-03 0,02929883 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 9,125E-03 0,02924788 ! ubiquinone metabolic process GO:0006743 7 7 0,000 9,125E-03 0,0291971 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 9,125E-03 0,0291465 ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 9,125E-03 0,02909607 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 9,125E-03 0,02904582 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 9,125E-03 0,02899574 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 9,125E-03 0,02894583 ! regulation of ATPase activity GO:0043462 7 7 0,000 9,125E-03 0,0288961 ! cell-cell recognition GO:0009988 8 7 0,000 9,125E-03 0,02884653 ! hormone catabolic process GO:0042447 7 7 0,000 9,125E-03 0,02879714 ! dopamine metabolic process GO:0042417 7 7 0,000 9,125E-03 0,02874791 ! cAMP biosynthetic process GO:0006171 7 7 0,000 9,125E-03 0,02869885 ! oxygen transport GO:0015671 7 7 0,000 9,125E-03 0,02864996 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 9,125E-03 0,02860124 ! regulation of mRNA stability GO:0043488 7 7 0,000 9,125E-03 0,02855268 ! biogenic amine catabolic process GO:0042402 7 7 0,000 9,125E-03 0,02850429 ! regulation of axon extension GO:0030516 7 7 0,000 9,125E-03 0,02845606 ! cell killing GO:0001906 7 7 0,000 9,125E-03 0,02840799 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 9,125E-03 0,02836008 ! adult feeding behavior GO:0008343 7 7 0,000 9,125E-03 0,02831234 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 9,125E-03 0,02826475 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 9,125E-03 0,02821733 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 9,125E-03 0,02817006 ! negative regulation of T cell activation GO:0050868 7 7 0,000 9,125E-03 0,02812296 ! response to cold GO:0009409 7 7 0,000 9,125E-03 0,02807601 ! regulation of skeletal muscle tissue development GO:0048641 8 8 0,000 0,01042261 0,03201477 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,01042261 0,0319615 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,01042261 0,03190841 ! positive regulation of translation GO:0045727 8 8 0,000 0,01042261 0,03185549 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,01042261 0,03180275 ! superoxide anion generation GO:0042554 8 8 0,000 0,01042261 0,03175019 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,01042261 0,03169779 ! cGMP metabolic process GO:0046068 8 8 0,000 0,01042261 0,03164557 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 8 8 0,000 0,01042261 0,03159352 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,01042261 0,03154165 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,01042261 0,03148994 ! negative regulation of bone remodeling GO:0046851 8 8 0,000 0,01042261 0,0314384 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,01042261 0,03138703 ! zinc ion transport GO:0006829 8 8 0,000 0,01042261 0,03133583 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,01042261 0,03128479 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,01042261 0,03123392 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,01042261 0,03118322 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,01042261 0,03113268 ! lipid localization GO:0010876 8 8 0,000 0,01042261 0,0310823 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,01042261 0,03103209 ! response to cAMP GO:0051591 8 8 0,000 0,01042261 0,03098204 ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,01042261 0,03093215 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,01042261 0,03088242 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,01042261 0,03083285 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,01042261 0,03078343 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,01042261 0,03073418 ! sensory perception of taste GO:0050909 8 8 0,000 0,01042261 0,03068508 ! organelle fusion GO:0048284 8 8 0,000 0,01042261 0,03063615 ! pancreas development GO:0031016 8 8 0,000 0,01042261 0,03058736 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,01042261 0,03053873 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! T cell selection GO:0045058 8 8 0,000 0,01042261 0,03049026 ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,01042261 0,03044194 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,01042261 0,03039377 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,01042261 0,03034576 ! sperm motility GO:0030317 8 8 0,000 0,01042261 0,03029789 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,01042261 0,03025018 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,01042261 0,03020261 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,01042261 0,0301552 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,01042261 0,03010794 ! phosphagen metabolic process GO:0006599 8 8 0,000 0,01042261 0,03006082 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,01042261 0,03001385 ! Golgi organization GO:0007030 8 8 0,000 0,01042261 0,02996703 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,01042261 0,02992035 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,01042261 0,02987382 ! positive regulation of endothelial cell migration GO:0010595 8 8 0,000 0,01042261 0,02982743 ! fructose metabolic process GO:0006000 8 8 0,000 0,01042261 0,02978118 ! mannose metabolic process GO:0006013 9 8 0,000 0,01042261 0,02973508 ! NAD metabolic process GO:0019674 8 8 0,000 0,01042261 0,02968912 ! sex determination GO:0007530 8 8 0,000 0,01042261 0,02964331 ! negative regulation of mitotic cell cycle GO:0045930 9 8 0,000 0,01042261 0,02959763 ! plasma membrane fusion GO:0045026 8 8 0,000 0,01042261 0,0295521 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 0,000 0,01042261 0,0295067 ! response to fungus GO:0009620 8 8 0,000 0,01042261 0,02946145 ! stem cell differentiation GO:0048863 8 8 0,000 0,01042261 0,02941633 ! alpha-beta T cell activation GO:0046631 8 8 0,000 0,01042261 0,02937135 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,01042261 0,02932651 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,01042261 0,0292818 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,01042261 0,02923723 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,01042261 0,0291928 ! regulation of vasodilation GO:0042312 8 8 0,000 0,01042261 0,0291485 ! vasoconstriction GO:0042310 8 8 0,000 0,01042261 0,02910434 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,01042261 0,02906031 ! muscle cell development GO:0055001 8 8 0,000 0,01042261 0,02901641 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,01042261 0,02897264 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,01042261 0,02892901 ! sensory perception of pain GO:0019233 8 8 0,000 0,01042261 0,02888551 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,01042261 0,02884214 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,01042261 0,0287989 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,01042261 0,02875578 ! chromatin silencing GO:0006342 8 8 0,000 0,01042261 0,0287128 ! tissue regeneration GO:0042246 8 8 0,000 0,01042261 0,02866994 ! salivary gland development GO:0007431 8 8 0,000 0,01042261 0,02862722 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,01042261 0,02858462 ! T cell homeostasis GO:0043029 8 8 0,000 0,01042261 0,02854214 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,01042261 0,0284998 ! peptidyl-serine modification GO:0018209 8 8 0,000 0,01042261 0,02845757 ! water homeostasis GO:0030104 8 8 0,000 0,01042261 0,02841548 ! cofactor transport GO:0051181 8 8 0,000 0,01042261 0,02837351 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,01042261 0,02833166 ! acid secretion GO:0046717 8 8 0,000 0,01042261 0,02828993 ! positive regulation of leukocyte migration GO:0002687 8 8 0,000 0,01042261 0,02824833 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,01042261 0,02820685 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,01042261 0,02816549 ! regulation of immunoglobulin production GO:0002637 8 8 0,000 0,01042261 0,02812425 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,01042261 0,02808313 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,01042261 0,02804214 ! regulation of RNA stability GO:0043487 8 8 0,000 0,01042261 0,02800126 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,01042261 0,0279605 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 0,000 0,01042261 0,02791986 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,01042261 0,02787934 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,01042261 0,02783893 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,01042261 0,02779864 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,01042261 0,02775847 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,01042261 0,02771842 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,01042261 0,02767848 ! peptide hormone secretion GO:0030072 8 8 0,000 0,01042261 0,02763865 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,01042261 0,02759894 ! actin filament polymerization GO:0030041 9 8 0,000 0,01042261 0,02755934 ! cytoplasmic sequestering of protein GO:0051220 8 8 0,000 0,01042261 0,02751986 ! peptide hormone processing GO:0016486 8 8 0,000 0,01042261 0,02748049 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,01042261 0,02744123 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,01042261 0,02740209 ! lactation GO:0007595 10 9 0,000 0,01171862 0,03076555 ! embryonic pattern specification GO:0009880 10 9 0,000 0,01171862 0,03072178 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,01171862 0,03067814 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,01171862 0,03063463 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,01171862 0,03059124 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,01171862 0,03054797 ! negative regulation of cell cycle process GO:0010948 9 9 0,000 0,01171862 0,03050482 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 0,000 0,01171862 0,0304618 ! viral genome replication GO:0019079 9 9 0,000 0,01171862 0,03041889 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,01171862 0,03037611 ! copper ion transport GO:0006825 9 9 0,000 0,01171862 0,03033345 ! lipid phosphorylation GO:0046834 9 9 0,000 0,01171862 0,0302909 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,01171862 0,03024848 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,01171862 0,03020617 ! RNA polyadenylation GO:0043631 9 9 0,000 0,01171862 0,03016399 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,01171862 0,03012192 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,01171862 0,03007996 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,01171862 0,03003813 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,01171862 0,02999641 ! phospholipid efflux GO:0033700 9 9 0,000 0,01171862 0,0299548 ! response to alkaloid GO:0043279 10 9 0,000 0,01171862 0,02991332 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,01171862 0,02987194 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,01171862 0,02983068 GO:0042107|cytokine metabolic process, ! positive regulation of endothelial cell proliferation GO:0001938 9 9 0,000 0,01171862 0,02978954 ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,01171862 0,0297485 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,01171862 0,02970758 ! response to ethanol GO:0045471 9 9 0,000 0,01171862 0,02966678 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 0,000 0,01171862 0,02962608 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,01171862 0,0295855 ! activation of pro-apoptotic gene products GO:0008633 9 9 0,000 0,01171862 0,02954503 ! methionine metabolic process GO:0006555 9 9 0,000 0,01171862 0,02950466 ! glutamine metabolic process GO:0006541 9 9 0,000 0,01171862 0,02946441 ! cerebral cortex development GO:0021987 9 9 0,000 0,01171862 0,02942427 ! response to osmotic stress GO:0006970 9 9 0,000 0,01171862 0,02938424 ! pigmentation during development GO:0048066 9 9 0,000 0,01171862 0,02934431 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,01171862 0,0293045 ! central nervous system neuron development GO:0021954 10 9 0,000 0,01171862 0,02926479 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,01171862 0,02922519 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,01171862 0,02918569 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,01171862 0,02914631 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,01171862 0,02910703 ! L-glutamate transport GO:0015813 9 9 0,000 0,01171862 0,02906785 GO:0015800|acidic amino acid transport, ! peptide secretion GO:0002790 9 9 0,000 0,01171862 0,02902878 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,01171862 0,02898982 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,01171862 0,02895096 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,01171862 0,0289122 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,01171862 0,02887355 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,01171862 0,028835 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,01171862 0,02879655 ! positive regulation of protein import into nucleus GO:0042307 9 9 0,000 0,01171862 0,02875821 ! DNA replication initiation GO:0006270 9 9 0,000 0,01171862 0,02871997 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,01171862 0,02868182 GO:0006692|prostanoid metabolic process, ! T cell differentiation in the thymus GO:0033077 9 9 0,000 0,01171862 0,02864378 ! regulation of cellular pH GO:0030641 9 9 0,000 0,01171862 0,02860585 ! histone acetylation GO:0016573 9 9 0,000 0,01171862 0,02856801 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,01171862 0,02853027 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,01171862 0,02849263 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,01171862 0,02845509 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,01171862 0,02841765 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,01171862 0,02838031 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,01171862 0,02834306 ! negative regulation of tissue remodeling GO:0034104 9 9 0,000 0,01171862 0,02830592 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,01171862 0,02826887 ! regulation of leukocyte migration GO:0002685 9 9 0,000 0,01171862 0,02823191 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,01171862 0,02819506 ! collagen catabolic process GO:0030574 9 9 0,000 0,01171862 0,0281583 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,01171862 0,02812163 ! purine base metabolic process GO:0006144 9 9 0,000 0,01171862 0,02808506 ! gas transport GO:0015669 9 9 0,000 0,01171862 0,02804859 ! cholesterol efflux GO:0033344 9 9 0,000 0,01171862 0,02801221 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,01171862 0,02797592 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,01171862 0,02793973 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,01171862 0,02790364 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,01171862 0,02786763 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 0,000 0,01171862 0,02783172 ! defense response to virus GO:0051607 9 9 0,000 0,01171862 0,0277959 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,01171862 0,02776017 ! actin filament-based movement GO:0030048 9 9 0,000 0,01171862 0,02772454 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,01301312 0,03074767 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,01301312 0,0307083 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 0,000 0,01301312 0,03066903 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,01301312 0,03062986 ! regulation of glucose metabolic process GO:0010906 10 10 0,000 0,01301312 0,0305908 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,01301312 0,03055183 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,01301312 0,03051296 ! neuron maturation GO:0042551 10 10 0,000 0,01301312 0,03047418 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,01301312 0,03043551 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,01301312 0,03039694 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,01301312 0,03035846 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,01301312 0,03032008 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,01301312 0,0302818 ! hormone secretion GO:0046879 10 10 0,000 0,01301312 0,03024361 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,01301312 0,03020552 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,01301312 0,03016753 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 0,000 0,01301312 0,03012963 ! inositol metabolic process GO:0006020 10 10 0,000 0,01301312 0,03009182 ! cAMP metabolic process GO:0046058 10 10 0,000 0,01301312 0,03005411 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,01301312 0,0300165 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,01301312 0,02997898 ! glial cell development GO:0021782 10 10 0,000 0,01301312 0,02994155 ! phototransduction GO:0007602 11 10 0,000 0,01301312 0,02990422 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,01301312 0,02986698 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,01301312 0,02982983 ! fat cell differentiation GO:0045444 10 10 0,000 0,01301312 0,02979277 ! myoblast differentiation GO:0045445 10 10 0,000 0,01301312 0,02975581 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,01301312 0,02971894 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,01301312 0,02968216 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,01301312 0,02964547 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,01301312 0,02960887 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,01301312 0,02957236 ! epidermis morphogenesis GO:0048730 10 10 0,000 0,01301312 0,02953594 ! protein polyubiquitination GO:0000209 10 10 0,000 0,01301312 0,02949961 ! glutamate metabolic process GO:0006536 11 10 0,000 0,01301312 0,02946337 ! plasma membrane organization GO:0007009 10 10 0,000 0,01301312 0,02942722 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,01301312 0,02939116 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cell-substrate junction assembly GO:0007044 11 10 0,000 0,01301312 0,02935518 ! lysosomal transport GO:0007041 10 10 0,000 0,01301312 0,0293193 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,01301312 0,0292835 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,01301312 0,02924778 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,01301312 0,02921216 GO:0042278|purine nucleoside metabolic process, ! exocrine system development GO:0035272 10 10 0,000 0,01301312 0,02917662 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,01301312 0,02914117 ! neuromuscular junction development GO:0007528 10 10 0,000 0,01301312 0,02910581 ! embryo implantation GO:0007566 11 10 0,000 0,01301312 0,02907053 ! regulation of protein binding GO:0043393 11 10 0,000 0,01301312 0,02903533 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,01301312 0,02900022 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,01301312 0,0289652 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,01301312 0,02893026 ! intermediate filament cytoskeleton organization GO:0045104 10 10 0,000 0,01301312 0,0288954 ! protein export from nucleus GO:0006611 10 10 0,000 0,01301312 0,02886063 ! negative regulation of immune response GO:0050777 10 10 0,000 0,01301312 0,02882594 ! cytolysis GO:0019835 10 10 0,000 0,01301312 0,02879134 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,01301312 0,02875681 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,01301312 0,02872238 ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,01301312 0,02868802 ! histone deacetylation GO:0016575 10 10 0,000 0,01301312 0,02865374 ! mRNA splice site selection GO:0006376 11 10 0,000 0,01301312 0,02861955 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,01301312 0,02858544 ! gland morphogenesis GO:0022612 10 10 0,000 0,01301312 0,02855141 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,01301312 0,02851746 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,01301312 0,02848359 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,01301312 0,0284498 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,01301312 0,02841609 ! regulation of erythrocyte differentiation GO:0045646 10 10 0,000 0,01301312 0,02838247 ! regulation of epidermis development GO:0045682 10 10 0,000 0,01301312 0,02834892 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,01301312 0,02831545 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,01301312 0,02828206 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,01301312 0,02824874 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,01301312 0,02821551 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,01301312 0,02818235 ! lymphocyte homeostasis GO:0002260 10 10 0,000 0,01301312 0,02814928 ! nerve development GO:0021675 10 10 0,000 0,01301312 0,02811628 ! epithelial to mesenchymal transition GO:0001837 10 10 0,000 0,01301312 0,02808335 ! gut development GO:0048565 10 10 0,000 0,01301312 0,02805051 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,01301312 0,02801774 ! positive regulation of neuron apoptosis GO:0043525 10 10 0,000 0,01301312 0,02798504 ! negative regulation of homeostatic process GO:0032845 10 10 0,000 0,01301312 0,02795243 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,01301312 0,02791989 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,01301312 0,02788742 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,01301312 0,02785503 ! protein stabilization GO:0050821 10 10 0,000 0,01301312 0,02782272 ! protein secretion GO:0009306 11 11 0,000 0,01430612 0,03055177 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,01430612 0,03051641 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 0,000 0,01430612 0,03048113 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,01430612 0,03044593 ! negative regulation of defense response GO:0031348 11 11 0,000 0,01430612 0,03041081 ! G1 phase of mitotic cell cycle GO:0000080 12 11 0,000 0,01430612 0,03037578 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,01430612 0,03034082 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,01430612 0,03030595 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,01430612 0,03027115 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,01430612 0,03023644 ! signal complex assembly GO:0007172 11 11 0,000 0,01430612 0,0302018 ! microtubule-based transport GO:0010970 11 11 0,000 0,01430612 0,03016725 ! endothelial cell migration GO:0043542 11 11 0,000 0,01430612 0,03013277 ! peroxisomal transport GO:0043574 11 11 0,000 0,01430612 0,03009837 ! protein amino acid methylation GO:0006479 11 11 0,000 0,01430612 0,03006405 GO:0008213|protein amino acid alkylation, ! protein amino acid acetylation GO:0006473 11 11 0,000 0,01430612 0,03002981 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 0,000 0,01430612 0,02999565 GO:0032388|positive regulation of intracellular transport, ! heart contraction GO:0060047 11 11 0,000 0,01430612 0,02996156 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,01430612 0,02992755 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,01430612 0,02989362 ! T cell proliferation GO:0042098 11 11 0,000 0,01430612 0,02985977 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,01430612 0,02982599 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,01430612 0,02979229 ! regulation of viral genome replication GO:0045069 11 11 0,000 0,01430612 0,02975866 ! spinal cord development GO:0021510 11 11 0,000 0,01430612 0,02972511 ! activation of MAPKK activity GO:0000186 12 11 0,000 0,01430612 0,02969164 ! smooth muscle contraction GO:0006939 11 11 0,000 0,01430612 0,02965824 ! cellular response to starvation GO:0009267 11 11 0,000 0,01430612 0,02962492 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 0,000 0,01430612 0,02959167 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,01430612 0,02955849 ! digestive system process GO:0022600 11 11 0,000 0,01430612 0,02952539 ! mitotic spindle organization GO:0007052 11 11 0,000 0,01430612 0,02949237 ! fucose metabolic process GO:0006004 11 11 0,000 0,01430612 0,02945941 ! apoptotic nuclear changes GO:0030262 11 11 0,000 0,01430612 0,02942653 ! monoamine transport GO:0015844 11 11 0,000 0,01430612 0,02939373 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,01430612 0,029361 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,01430612 0,02932834 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 0,000 0,01430612 0,02929575 ! body fluid secretion GO:0007589 11 11 0,000 0,01430612 0,02926324 ! G1/S transition checkpoint GO:0031575 12 11 0,000 0,01430612 0,02923079 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 0,000 0,01430612 0,02919842 ! intermediate filament-based process GO:0045103 11 11 0,000 0,01430612 0,02916612 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,01430612 0,02913389 GO:0060415|muscle tissue morphogenesis, ! interaction with host GO:0051701 11 11 0,000 0,01430612 0,02910174 ! membrane depolarization GO:0051899 11 11 0,000 0,01430612 0,02906965 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,01430612 0,02903764 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,01430612 0,02900569 ! regulation of monooxygenase activity GO:0032768 11 11 0,000 0,01430612 0,02897382 ! oogenesis GO:0048477 11 11 0,000 0,01430612 0,02894201 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,01430612 0,02891028 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,01430612 0,02887861 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 0,000 0,01430612 0,02884702 GO:0006109|regulation of carbohydrate metabolic process, ! vitamin transport GO:0051180 11 11 0,000 0,01430612 0,02881549 ! muscle maintenance GO:0046716 12 11 0,000 0,01430612 0,02878403 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,01430612 0,02875264 ! hindbrain development GO:0030902 11 11 0,000 0,01430612 0,02872132 ! steroid catabolic process GO:0006706 11 11 0,000 0,01430612 0,02869007 ! endocrine process GO:0050886 11 11 0,000 0,01430612 0,02865889 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,01430612 0,02862777 ! proximal/distal pattern formation GO:0009954 11 11 0,000 0,01430612 0,02859672 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,01430612 0,02856574 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,01430612 0,02853482 ! negative regulation of lymphocyte activation GO:0051250 11 11 0,000 0,01430612 0,02850397 ! positive regulation of protein catabolic process GO:0045732 12 12 0,000 0,01559761 0,03104362 ! translational initiation GO:0006413 12 12 0,000 0,01559761 0,03101013 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 0,000 0,01559761 0,03097671 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,01559761 0,03094337 ! initiation of viral infection GO:0019059 12 12 0,000 0,01559761 0,0309101 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,01559761 0,0308769 ! iron ion transport GO:0006826 13 12 0,000 0,01559761 0,03084377 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,01559761 0,03081071 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,01559761 0,03077772 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,01559761 0,0307448 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,01559761 0,03071196 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,01559761 0,03067918 ! collagen metabolic process GO:0032963 12 12 0,000 0,01559761 0,03064647 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,01559761 0,03061383 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,01559761 0,03058127 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,01559761 0,03054877 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,01559761 0,03051634 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,01559761 0,03048398 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,01559761 0,03045169 GO:0042744|hydrogen peroxide catabolic process, ! actomyosin structure organization GO:0031032 12 12 0,000 0,01559761 0,03041946 ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,01559761 0,03038731 ! retinoid metabolic process GO:0001523 12 12 0,000 0,01559761 0,03035522 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,01559761 0,0303232 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,01559761 0,03029124 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,01559761 0,03025936 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,01559761 0,03022754 ! acute-phase response GO:0006953 12 12 0,000 0,01559761 0,03019579 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,01559761 0,0301641 ! vacuolar transport GO:0007034 12 12 0,000 0,01559761 0,03013249 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,01559761 0,03010093 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,01559761 0,03006945 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,01559761 0,03003803 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,01559761 0,03000667 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,01559761 0,02997538 ! male gonad development GO:0008584 12 12 0,000 0,01559761 0,02994416 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,01559761 0,029913 ! regulation of alpha-beta T cell activation GO:0046634 12 12 0,000 0,01559761 0,0298819 ! renal system process GO:0003014 12 12 0,000 0,01559761 0,02985087 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,01559761 0,02981991 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,01559761 0,02978901 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,01559761 0,02975817 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,01559761 0,02972739 ! pallium development GO:0021543 13 12 0,000 0,01559761 0,02969668 ! cell fate determination GO:0001709 12 12 0,000 0,01559761 0,02966604 ! regulation of chromosome organization GO:0033044 12 12 0,000 0,01559761 0,02963545 ! positive regulation of multicellular organism growth GO:0040018 12 12 0,000 0,01559761 0,02960493 ! somitogenesis GO:0001756 13 12 0,000 0,01559761 0,02957448 ! G1 phase GO:0051318 13 12 0,000 0,01559761 0,02954408 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,01559761 0,02951375 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,01559761 0,02948348 ! detection of light stimulus GO:0009583 13 12 0,000 0,01559761 0,02945327 ! synaptogenesis GO:0007416 12 12 0,000 0,01559761 0,02942312 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,01559761 0,02939304 ! hormone transport GO:0009914 12 12 0,000 0,01559761 0,02936301 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,01559761 0,02933305 ! heme biosynthetic process GO:0006783 12 12 0,000 0,01559761 0,02930315 ! spermatid differentiation GO:0048515 13 12 0,000 0,01559761 0,02927331 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,01559761 0,02924353 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,01559761 0,02921381 ! neural tube closure GO:0001843 13 12 0,000 0,01559761 0,02918415 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 0,000 0,01559761 0,02915455 ! negative regulation of translation GO:0017148 12 12 0,000 0,01559761 0,02912502 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 0,000 0,01559761 0,02909554 ! positive regulation of DNA replication GO:0045740 14 13 0,000 0,01688759 0,03147 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 0,000 0,01688759 0,03143822 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,01688759 0,03140649 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,01688759 0,03137483 ! phenol metabolic process GO:0018958 13 13 0,000 0,01688759 0,03134324 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! G2/M transition of mitotic cell cycle GO:0000086 13 13 0,000 0,01688759 0,0313117 ! gluconeogenesis GO:0006094 13 13 0,000 0,01688759 0,03128024 ! negative regulation of hormone secretion GO:0046888 13 13 0,000 0,01688759 0,03124883 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,01688759 0,03121749 GO:0019692|deoxyribose phosphate metabolic process, ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,01688759 0,03118621 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 0,000 0,01688759 0,03115499 ! regeneration GO:0031099 13 13 0,000 0,01688759 0,03112383 ! keratinization GO:0031424 13 13 0,000 0,01688759 0,03109274 ! post-embryonic development GO:0009791 14 13 0,000 0,01688759 0,03106171 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,01688759 0,03103074 ! patterning of blood vessels GO:0001569 13 13 0,000 0,01688759 0,03099984 ! vasculogenesis GO:0001570 13 13 0,000 0,01688759 0,03096899 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,01688759 0,03093821 ! regulation of innate immune response GO:0045088 13 13 0,000 0,01688759 0,03090748 ! mitochondrial membrane organization GO:0007006 13 13 0,000 0,01688759 0,03087682 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 0,000 0,01688759 0,03084622 ! negative regulation of DNA replication GO:0008156 13 13 0,000 0,01688759 0,03081568 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 0,000 0,01688759 0,0307852 ! response to corticosteroid stimulus GO:0031960 13 13 0,000 0,01688759 0,03075478 GO:0051384|response to glucocorticoid stimulus, ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,01688759 0,03072442 ! autophagy GO:0006914 13 13 0,000 0,01688759 0,03069412 ! receptor metabolic process GO:0043112 14 13 0,000 0,01688759 0,03066388 ! actin filament bundle formation GO:0051017 13 13 0,000 0,01688759 0,0306337 ! negative regulation of protein catabolic process GO:0042177 13 13 0,000 0,01688759 0,03060357 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 0,000 0,01688759 0,03057351 ! regulation of endothelial cell migration GO:0010594 13 13 0,000 0,01688759 0,03054351 ! response to endoplasmic reticulum stress GO:0034976 13 13 0,000 0,01688759 0,03051356 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,01688759 0,03048368 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,01688759 0,03045385 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,01688759 0,03042408 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,01688759 0,03039437 ! regulation of viral reproduction GO:0050792 13 13 0,000 0,01688759 0,03036472 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,01688759 0,03033512 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,01688759 0,03030558 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,01688759 0,0302761 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,01688759 0,03024668 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,01688759 0,03021732 ! vasodilation GO:0042311 14 13 0,000 0,01688759 0,03018801 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,01688759 0,03015875 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 0,000 0,01688759 0,03012956 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,01688759 0,03010042 GO:0006664|glycolipid metabolic process, ! positive regulation of locomotion GO:0040017 13 13 0,000 0,01688759 0,03007134 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! neural crest cell migration GO:0001755 14 13 0,000 0,01688759 0,03004231 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,01688759 0,03001334 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,01688759 0,02998443 ! immunoglobulin production GO:0002377 13 13 0,000 0,01688759 0,02995557 GO:0002440|production of molecular mediator of immune response, ! negative regulation of intracellular transport GO:0032387 13 13 0,000 0,01688759 0,02992676 ! negative regulation of leukocyte activation GO:0002695 13 13 0,000 0,01688759 0,02989802 ! cell-cell junction organization GO:0045216 13 13 0,000 0,01688759 0,02986932 ! regulation of cell-substrate adhesion GO:0010810 14 13 0,000 0,01688759 0,02984069 GO:0001952|regulation of cell-matrix adhesion, ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,01688759 0,0298121 ! response to cytokine stimulus GO:0034097 13 13 0,000 0,01688759 0,02978357 ! activation of JUN kinase activity GO:0007257 13 13 0,000 0,01688759 0,0297551 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,01688759 0,02972668 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,01688759 0,02969832 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,01688759 0,02967 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,01688759 0,02964175 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,01688759 0,02961354 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,01688759 0,02958539 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,01688759 0,0295573 ! blastocyst development GO:0001824 13 13 0,000 0,01688759 0,02952925 ! telomere organization GO:0032200 13 13 0,000 0,01688759 0,02950126 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,01688759 0,02947333 ! regulation of amine transport GO:0051952 13 13 0,000 0,01688759 0,02944544 ! tissue homeostasis GO:0001894 13 13 0,000 0,01688759 0,02941761 GO:0048871|multicellular organismal homeostasis, ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,01688759 0,02938983 ! protein tetramerization GO:0051262 13 13 0,000 0,01688759 0,02936211 ! neuron fate commitment GO:0048663 14 14 0,000 0,01817608 0,03157258 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,01817608 0,03154285 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,01817608 0,03151318 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,01817608 0,03148356 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,01817608 0,031454 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,01817608 0,03142449 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,01817608 0,03139504 ! protein amino acid acylation GO:0043543 14 14 0,000 0,01817608 0,03136564 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,01817608 0,0313363 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,01817608 0,03130702 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,01817608 0,03127779 ! vesicle docking GO:0048278 14 14 0,000 0,01817608 0,03124861 ! superoxide metabolic process GO:0006801 15 14 0,000 0,01817608 0,03121949 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,01817608 0,03119042 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,01817608 0,0311614 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,01817608 0,03113244 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,01817608 0,03110354 ! hair cycle GO:0042633 14 14 0,000 0,01817608 0,03107468 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,01817608 0,03104588 ! positive regulation of epithelial cell proliferation GO:0050679 14 14 0,000 0,01817608 0,03101714 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,01817608 0,03098844 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to retinoic acid GO:0032526 14 14 0,000 0,01817608 0,0309598 GO:0033189|response to vitamin A, ! multicellular organismal response to stress GO:0033555 14 14 0,000 0,01817608 0,03093122 ! lysosome organization GO:0007040 14 14 0,000 0,01817608 0,03090268 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,01817608 0,0308742 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,01817608 0,03084577 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 0,000 0,01817608 0,0308174 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 14 14 0,000 0,01817608 0,03078907 ! primary neural tube formation GO:0014020 15 14 0,000 0,01817608 0,0307608 ! peptide cross-linking GO:0018149 14 14 0,000 0,01817608 0,03073258 ! regulation of behavior GO:0050795 14 14 0,000 0,01817608 0,03070441 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,01817608 0,03067629 ! base-excision repair GO:0006284 14 14 0,000 0,01817608 0,03064822 ! response to organic cyclic substance GO:0014070 15 14 0,000 0,01817608 0,03062021 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,01817608 0,03059225 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,01817608 0,03056433 ! formation of primary germ layer GO:0001704 14 14 0,000 0,01817608 0,03053647 GO:0001707|mesoderm formation, ! DNA modification GO:0006304 14 14 0,000 0,01817608 0,03050866 ! collagen fibril organization GO:0030199 14 14 0,000 0,01817608 0,0304809 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,01817608 0,03045319 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,01817608 0,03042553 ! positive regulation of inflammatory response GO:0050729 14 14 0,000 0,01817608 0,03039792 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,01817608 0,03037036 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,01817608 0,03034285 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,01817608 0,03031539 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,01817608 0,03028798 ! response to molecule of bacterial origin GO:0002237 14 14 0,000 0,01817608 0,03026062 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,01817608 0,03023331 ! protein import into nucleus, translocation GO:0000060 15 15 0,000 0,01946306 0,03234483 ! positive regulation of fibroblast proliferation GO:0048146 15 15 0,000 0,01946306 0,03231569 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,01946306 0,0322866 ! positive regulation of ossification GO:0045778 15 15 0,000 0,01946306 0,03225757 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,01946306 0,03222859 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,01946306 0,03219965 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,01946306 0,03217078 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,01946306 0,03214195 ! response to vitamin GO:0033273 15 15 0,000 0,01946306 0,03211317 ! regulation of transcription factor import into nucleus GO:0042990 15 15 0,000 0,01946306 0,03208445 ! striated muscle cell differentiation GO:0051146 16 15 0,000 0,01946306 0,03205578 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,01946306 0,03202716 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,01946306 0,03199859 ! insulin receptor signaling pathway GO:0008286 17 15 0,000 0,01946306 0,03197007 ! ovarian follicle development GO:0001541 15 15 0,000 0,01946306 0,0319416 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,01946306 0,03191318 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,01946306 0,03188481 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,01946306 0,0318565 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,01946306 0,03182823 ! ER-nuclear signaling pathway GO:0006984 15 15 0,000 0,01946306 0,03180001 ! heme metabolic process GO:0042168 15 15 0,000 0,01946306 0,03177185 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,01946306 0,03174373 ! chromosome condensation GO:0030261 15 15 0,000 0,01946306 0,03171566 ! response to starvation GO:0042594 15 15 0,000 0,01946306 0,03168765 ! response to ionizing radiation GO:0010212 16 15 0,000 0,01946306 0,03165968 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,01946306 0,03163176 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,01946306 0,03160389 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,01946306 0,03157607 GO:0030500|regulation of bone mineralization, ! regulation of production of molecular mediator of immune response GO:0002700 15 15 0,000 0,01946306 0,0315483 ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,01946306 0,03152058 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,01946306 0,0314929 ! phospholipid transport GO:0015914 15 15 0,000 0,01946306 0,03146528 ! leukocyte homeostasis GO:0001776 15 15 0,000 0,01946306 0,0314377 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,01946306 0,03141017 ! glutathione metabolic process GO:0006749 16 15 0,000 0,01946306 0,03138269 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,01946306 0,03135526 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of B cell activation GO:0050871 15 15 0,000 0,01946306 0,03132787 ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,01946306 0,03130054 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,01946306 0,03127325 ! negative regulation of transcription factor activity GO:0043433 16 15 0,000 0,01946306 0,03124601 GO:0090048|negative regulation of transcription regulator activity, ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,01946306 0,03121881 ! negative regulation of cell activation GO:0050866 15 15 0,000 0,01946306 0,03119167 ! protein homooligomerization GO:0051260 15 15 0,000 0,01946306 0,03116457 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,01946306 0,03113751 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 0,000 0,02074854 0,03316527 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 0,000 0,02074854 0,03313653 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! alkaloid metabolic process GO:0009820 16 16 0,000 0,02074854 0,03310784 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,02074854 0,0330792 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,02074854 0,03305061 ! learning GO:0007612 16 16 0,000 0,02074854 0,03302207 ! circadian rhythm GO:0007623 16 16 0,000 0,02074854 0,03299358 ! positive regulation of mitosis GO:0045840 16 16 0,000 0,02074854 0,03296514 GO:0051785|positive regulation of nuclear division, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 0,000 0,02074854 0,03293674 ! vacuole organization GO:0007033 16 16 0,000 0,02074854 0,0329084 ! cellular response to reactive oxygen species GO:0034614 16 16 0,000 0,02074854 0,0328801 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,02074854 0,03285185 ! segmentation GO:0035282 17 16 0,000 0,02074854 0,03282366 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,02074854 0,0327955 ! triglyceride metabolic process GO:0006641 16 16 0,000 0,02074854 0,0327674 ! iron ion homeostasis GO:0055072 16 16 0,000 0,02074854 0,03273935 ! positive regulation of cell development GO:0010720 16 16 0,000 0,02074854 0,03271134 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,02074854 0,03268338 ! lymphocyte proliferation GO:0046651 16 16 0,000 0,02074854 0,03265547 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,02074854 0,03262761 ! pentose metabolic process GO:0019321 16 16 0,000 0,02074854 0,03259979 ! fatty acid transport GO:0015908 16 16 0,000 0,02074854 0,03257203 ! positive regulation of MAPKKK cascade GO:0043410 17 16 0,000 0,02074854 0,0325443 ! cellular response to nutrient levels GO:0031669 16 16 0,000 0,02074854 0,03251663 ! cofactor catabolic process GO:0051187 16 16 0,000 0,02074854 0,032489 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,02074854 0,03246142 ! polyol metabolic process GO:0019751 16 16 0,000 0,02074854 0,03243389 ! serine family amino acid metabolic process GO:0009069 16 16 0,000 0,02074854 0,03240641 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,02074854 0,03237897 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,02074854 0,03235157 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,02074854 0,03232423 GO:0001841|neural tube formation, ! positive regulation of catabolic process GO:0009896 16 16 0,000 0,02074854 0,03229692 ! regulation of JUN kinase activity GO:0043506 17 16 0,000 0,02074854 0,03226967 GO:0043507|positive regulation of JUN kinase activity, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,02074854 0,03224246 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,02074854 0,0322153 ! regulation of coagulation GO:0050818 17 16 0,000 0,02074854 0,03218818 ! regulation of fibroblast proliferation GO:0048145 17 17 0,000 0,02203252 0,03415134 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 0,000 0,02203252 0,03412264 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,02203252 0,03409399 ! positive regulation of cell adhesion GO:0045785 17 17 0,000 0,02203252 0,03406539 ! myelination GO:0042552 17 17 0,000 0,02203252 0,03403683 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,02203252 0,03400832 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,02203252 0,03397987 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,02203252 0,03395145 ! leukocyte adhesion GO:0007159 17 17 0,000 0,02203252 0,03392309 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,02203252 0,03389477 ! sensory perception of smell GO:0007608 17 17 0,000 0,02203252 0,03386651 ! glucose transport GO:0015758 17 17 0,000 0,02203252 0,03383828 ! cell junction assembly GO:0034329 18 17 0,000 0,02203252 0,03381011 ! tissue remodeling GO:0048771 17 17 0,000 0,02203252 0,03378198 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,02203252 0,0337539 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,02203252 0,03372586 ! development of primary male sexual characteristics GO:0046546 17 17 0,000 0,02203252 0,03369788 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,02203252 0,03366993 ! neural crest cell development GO:0014032 19 17 0,000 0,02203252 0,03364204 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 18 17 0,000 0,02203252 0,03361419 ! negative regulation of cell development GO:0010721 18 17 0,000 0,02203252 0,03358639 GO:0050768|negative regulation of neurogenesis, ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,02203252 0,03355863 GO:0002764|immune response-regulating signal transduction, ! cell recognition GO:0008037 18 17 0,000 0,02203252 0,03353092 ! regulation of oxidoreductase activity GO:0051341 17 17 0,000 0,02203252 0,03350325 ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,02203252 0,03347563 ! regulation of osteoblast differentiation GO:0045667 17 17 0,000 0,02203252 0,03344806 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,02203252 0,03342053 ! pigmentation GO:0043473 17 17 0,000 0,02203252 0,03339304 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,02203252 0,0333656 ! adult locomotory behavior GO:0008344 17 17 0,000 0,02203252 0,03333821 ! embryonic organ development GO:0048568 17 17 0,000 0,02203252 0,03331086 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,02203252 0,03328356 ! liver development GO:0001889 17 17 0,000 0,02203252 0,0332563 ! gene silencing GO:0016458 17 17 0,000 0,02203252 0,03322908 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,02331501 0,03513456 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,02331501 0,03510585 ! regulation of cellular catabolic process GO:0031329 18 18 0,000 0,02331501 0,03507719 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,02331501 0,03504858 ! meiosis I GO:0007127 18 18 0,000 0,02331501 0,03502002 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 0,000 0,02331501 0,0349915 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,02331501 0,03496303 ! membrane docking GO:0022406 18 18 0,000 0,02331501 0,0349346 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,02331501 0,03490623 ! mononuclear cell proliferation GO:0032943 18 18 0,000 0,02331501 0,03487789 GO:0070661|leukocyte proliferation, ! response to calcium ion GO:0051592 18 18 0,000 0,02331501 0,03484961 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,02331501 0,03482136 ! hexose transport GO:0008645 18 18 0,000 0,02331501 0,03479317 GO:0015749|monosaccharide transport, ! cholesterol homeostasis GO:0042632 18 18 0,000 0,02331501 0,03476502 GO:0055092|sterol homeostasis, ! striated muscle contraction GO:0006941 18 18 0,000 0,02331501 0,03473691 ! neutral lipid metabolic process GO:0006638 18 18 0,000 0,02331501 0,03470886 GO:0006639|acylglycerol metabolic process, ! negative regulation of DNA binding GO:0043392 19 18 0,000 0,02331501 0,03468084 ! ceramide metabolic process GO:0006672 18 18 0,000 0,02331501 0,03465287 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,02331501 0,03462495 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,02331501 0,03459707 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,02331501 0,03456924 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,02331501 0,03454145 ! B cell differentiation GO:0030183 18 18 0,000 0,02331501 0,03451371 ! cellular response to extracellular stimulus GO:0031668 18 18 0,000 0,02331501 0,03448601 ! ensheathment of neurons GO:0007272 18 18 0,000 0,02331501 0,03445835 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 18 18 0,000 0,02331501 0,03443074 ! negative regulation of catabolic process GO:0009895 18 18 0,000 0,02331501 0,03440317 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 0,000 0,02331501 0,03437565 ! DNA damage checkpoint GO:0000077 19 19 0,000 0,024596 0,03623536 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,024596 0,03620641 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,024596 0,03617752 GO:0006956|complement activation, ! negative regulation of DNA metabolic process GO:0051053 19 19 0,000 0,024596 0,03614867 ! glial cell differentiation GO:0010001 19 19 0,000 0,024596 0,03611987 ! regulation of pH GO:0006885 19 19 0,000 0,024596 0,03609111 ! regulation of JAK-STAT cascade GO:0046425 19 19 0,000 0,024596 0,0360624 ! feeding behavior GO:0007631 19 19 0,000 0,024596 0,03603373 ! regulation of endothelial cell proliferation GO:0001936 19 19 0,000 0,024596 0,03600511 ! peroxisome organization GO:0007031 19 19 0,000 0,024596 0,03597653 ! positive regulation of T cell proliferation GO:0042102 19 19 0,000 0,024596 0,035948 ! regulation of striated muscle tissue development GO:0016202 20 19 0,000 0,024596 0,03591952 ! multicellular organismal metabolic process GO:0044236 19 19 0,000 0,024596 0,03589108 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 0,000 0,024596 0,03586268 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,024596 0,03583433 ! cellular response to oxidative stress GO:0034599 19 19 0,000 0,024596 0,03580603 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,024596 0,03577777 ! positive regulation of T cell differentiation GO:0045582 19 19 0,000 0,024596 0,03574955 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,024596 0,03572138 ! peripheral nervous system development GO:0007422 19 19 0,000 0,024596 0,03569325 ! regulation of protein stability GO:0031647 19 19 0,000 0,024596 0,03566517 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,024596 0,03563713 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,024596 0,03560914 ! dorsal/ventral pattern formation GO:0009953 19 19 0,000 0,024596 0,03558119 ! eye morphogenesis GO:0048592 19 19 0,000 0,024596 0,03555328 ! regulation of cell shape GO:0008360 21 19 0,000 0,024596 0,03552542 ! placenta development GO:0001890 19 19 0,000 0,024596 0,0354976 ! response to heat GO:0009408 19 19 0,000 0,024596 0,03546982 ! regulation of muscle development GO:0048634 21 20 0,000 0,0258755 0,03728581 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,0258755 0,03725668 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,0258755 0,03722759 ! negative regulation of binding GO:0051100 21 20 0,000 0,0258755 0,03719855 ! organic ether metabolic process GO:0018904 20 20 0,000 0,0258755 0,03716956 GO:0006662|glycerol ether metabolic process, ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 0,000 0,0258755 0,03714061 ! neural tube development GO:0021915 21 20 0,000 0,0258755 0,03711171 ! nucleus organization GO:0006997 20 20 0,000 0,0258755 0,03708285 ! phagocytosis GO:0006909 21 20 0,000 0,0258755 0,03705404 ! positive regulation of gene-specific transcription GO:0043193 20 20 0,000 0,0258755 0,03702527 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,0258755 0,03699654 ! protein targeting to membrane GO:0006612 22 20 0,000 0,0258755 0,03696786 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,0258755 0,03693923 ! chromatin remodeling GO:0006338 20 20 0,000 0,0258755 0,03691064 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,0258755 0,03688209 ! peptidyl-tyrosine modification GO:0018212 21 20 0,000 0,0258755 0,03685359 ! lipid oxidation GO:0034440 20 20 0,000 0,0258755 0,03682513 GO:0019395|fatty acid oxidation, ! female gamete generation GO:0007292 20 20 0,000 0,0258755 0,03679672 ! negative regulation of neuron apoptosis GO:0043524 21 20 0,000 0,0258755 0,03676835 ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,0258755 0,03674002 ! RNA modification GO:0009451 20 20 0,000 0,0258755 0,03671174 ! single fertilization GO:0007338 21 20 0,000 0,0258755 0,0366835 ! regulation of B cell activation GO:0050864 20 20 0,000 0,0258755 0,0366553 ! mitotic sister chromatid segregation GO:0000070 21 21 0,000 0,02715351 0,03843618 ! mRNA catabolic process GO:0006402 21 21 0,000 0,02715351 0,03840669 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 0,000 0,02715351 0,03837723 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,02715351 0,03834782 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! mammary gland development GO:0030879 23 21 0,000 0,02715351 0,03831846 ! protein amino acid lipidation GO:0006497 21 21 0,000 0,02715351 0,03828914 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,02715351 0,03825987 ! Notch signaling pathway GO:0007219 22 21 0,000 0,02715351 0,03823064 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,02715351 0,03820146 ! organic anion transport GO:0015711 21 21 0,000 0,02715351 0,03817232 ! cholesterol transport GO:0030301 21 21 0,000 0,02715351 0,03814322 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,02715351 0,03811417 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,02715351 0,03808517 GO:0032313|regulation of Rab GTPase activity, ! DNA integrity checkpoint GO:0031570 21 21 0,000 0,02715351 0,03805621 ! regulation of protein import into nucleus GO:0042306 21 21 0,000 0,02715351 0,03802729 ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,02715351 0,03799841 ! regulation of action potential in neuron GO:0019228 21 21 0,000 0,02715351 0,03796958 ! regulation of multicellular organism growth GO:0040014 21 21 0,000 0,02715351 0,0379408 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 0,000 0,02715351 0,03791205 ! regulation of proteolysis GO:0030162 21 21 0,000 0,02715351 0,03788335 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 0,000 0,02715351 0,0378547 ! cellular response to insulin stimulus GO:0032869 23 21 0,000 0,02715351 0,03782609 ! negative regulation of protein transport GO:0051224 21 21 0,000 0,02715351 0,03779752 ! RNA export from nucleus GO:0006405 22 22 0,000 0,02843002 0,03954455 ! positive regulation of DNA metabolic process GO:0051054 23 22 0,000 0,02843002 0,03951473 ! sister chromatid segregation GO:0000819 22 22 0,000 0,02843002 0,03948495 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,02843002 0,03945522 ! regulation of ion transport GO:0043269 22 22 0,000 0,02843002 0,03942553 ! odontogenesis GO:0042476 22 22 0,000 0,02843002 0,03939589 ! cell junction organization GO:0034330 23 22 0,000 0,02843002 0,03936629 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 0,000 0,02843002 0,03933673 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! hormone-mediated signaling GO:0009755 22 22 0,000 0,02843002 0,03930722 ! maintenance of protein location in cell GO:0032507 23 22 0,000 0,02843002 0,03927776 ! ovulation cycle process GO:0022602 22 22 0,000 0,02843002 0,03924834 ! spindle organization GO:0007051 22 22 0,000 0,02843002 0,03921896 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,02843002 0,03918962 ! cell chemotaxis GO:0060326 23 22 0,000 0,02843002 0,03916034 GO:0030595|leukocyte chemotaxis, ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,02843002 0,03913109 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,02843002 0,03910189 ! male sex differentiation GO:0046661 22 22 0,000 0,02843002 0,03907273 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,02843002 0,03904361 ! biopolymer methylation GO:0043414 22 22 0,000 0,02843002 0,03901454 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 0,000 0,02843002 0,03898551 ! detection of external stimulus GO:0009581 23 22 0,000 0,02843002 0,03895653 ! neuron migration GO:0001764 22 22 0,000 0,02843002 0,03892758 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,02843002 0,03889868 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 0,000 0,02843002 0,03886983 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,02843002 0,03884101 ! aerobic respiration GO:0009060 22 22 0,000 0,02843002 0,03881224 ! cytokine production GO:0001816 22 22 0,000 0,02843002 0,03878351 ! cytokinesis GO:0000910 23 22 0,000 0,02843002 0,03875483 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,02843002 0,03872619 ! response to hydrogen peroxide GO:0042542 24 23 0,000 0,02970505 0,04043309 ! viral infectious cycle GO:0019058 23 23 0,000 0,02970505 0,04040325 ! regulation of hormone secretion GO:0046883 23 23 0,000 0,02970505 0,04037345 ! response to estrogen stimulus GO:0043627 23 23 0,000 0,02970505 0,0403437 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,02970505 0,04031399 ! mitotic cell cycle checkpoint GO:0007093 24 23 0,000 0,02970505 0,04028433 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,02970505 0,04025471 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,02970505 0,04022513 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,02970505 0,0401956 ! female gonad development GO:0008585 23 23 0,000 0,02970505 0,04016611 ! monovalent inorganic cation homeostasis GO:0055067 23 23 0,000 0,02970505 0,04013666 ! lipid homeostasis GO:0055088 23 23 0,000 0,02970505 0,04010725 ! calcium-mediated signaling GO:0019722 23 23 0,000 0,02970505 0,04007789 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,02970505 0,04004857 ! regulation of JNK cascade GO:0046328 25 23 0,000 0,02970505 0,0400193 ! cell projection assembly GO:0030031 25 23 0,000 0,02970505 0,03999007 ! mitochondrial transport GO:0006839 24 24 0,000 0,03097859 0,04167411 ! regulation of action potential GO:0001508 24 24 0,000 0,03097859 0,04164372 ! gliogenesis GO:0042063 24 24 0,000 0,03097859 0,04161336 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 0,000 0,03097859 0,04158305 ! cellular amino acid biosynthetic process GO:0008652 24 24 0,000 0,03097859 0,04155279 ! glucose homeostasis GO:0042593 24 24 0,000 0,03097859 0,04152257 GO:0033500|carbohydrate homeostasis, ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,03097859 0,04149239 ! T cell differentiation GO:0030217 24 24 0,000 0,03097859 0,04146226 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,03097859 0,04143217 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,03097859 0,04140213 ! ovulation cycle GO:0042698 24 24 0,000 0,03097859 0,04137213 ! fertilization GO:0009566 25 24 0,000 0,03097859 0,04134217 ! maintenance of protein location GO:0045185 25 24 0,000 0,03097859 0,04131225 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,03097859 0,04128238 ! androgen receptor signaling pathway GO:0030521 24 24 0,000 0,03097859 0,04125255 ! glucan metabolic process GO:0044042 25 24 0,000 0,03097859 0,04122277 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,03225064 0,04288451 ! negative regulation of secretion GO:0051048 26 25 0,000 0,03225064 0,04285359 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,03225064 0,04282271 ! regulation of gene-specific transcription GO:0032583 25 25 0,000 0,03225064 0,04279188 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,03225064 0,0427611 ! cellular component disassembly GO:0022411 26 25 0,000 0,03225064 0,04273036 ! endosome transport GO:0016197 25 25 0,000 0,03225064 0,04269966 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,03225064 0,04266901 ! regulation of intracellular protein transport GO:0033157 25 25 0,000 0,03225064 0,0426384 ! development of primary female sexual characteristics GO:0046545 25 25 0,000 0,03225064 0,04260783 GO:0046660|female sex differentiation, ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,03225064 0,04257731 ! regulation of T cell proliferation GO:0042129 25 25 0,000 0,03225064 0,04254683 ! excretion GO:0007588 25 25 0,000 0,03225064 0,0425164 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,03225064 0,04248601 ! gastrulation GO:0007369 25 25 0,000 0,03225064 0,04245566 ! heart morphogenesis GO:0003007 25 25 0,000 0,03225064 0,04242536 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,03225064 0,0423951 ! regulation of endocytosis GO:0030100 25 25 0,000 0,03225064 0,04236488 ! negative regulation of immune system process GO:0002683 25 25 0,000 0,03225064 0,04233471 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,03225064 0,04230457 ! positive regulation of cytokine production GO:0001819 25 25 0,000 0,03225064 0,04227449 ! positive regulation of defense response GO:0031349 26 26 0,000 0,03352121 0,04390873 ! glycolysis GO:0006096 26 26 0,000 0,03352121 0,04387755 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,03352121 0,0438464 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 0,000 0,03352121 0,04381531 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,03352121 0,04378425 ! negative regulation of cell migration GO:0030336 26 26 0,000 0,03352121 0,04375325 ! cellular defense response GO:0006968 26 26 0,000 0,03352121 0,04372228 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,03352121 0,04369136 ! regulation of T cell differentiation GO:0045580 26 26 0,000 0,03352121 0,04366048 ! double-strand break repair GO:0006302 27 26 0,000 0,03352121 0,04362965 ! regulation of protein secretion GO:0050708 26 26 0,000 0,03352121 0,04359886 ! germ cell development GO:0007281 27 26 0,000 0,03352121 0,04356811 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,03352121 0,04353741 GO:0035150|regulation of tube size, ! pigment metabolic process GO:0042440 26 26 0,000 0,03352121 0,04350675 ! response to insulin stimulus GO:0032868 28 26 0,000 0,03352121 0,04347613 ! maintenance of location in cell GO:0051651 27 26 0,000 0,03352121 0,04344556 ! synapse organization GO:0050808 26 26 0,000 0,03352121 0,04341503 ! chloride transport GO:0006821 27 27 0,000 0,03479029 0,04502704 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 0,000 0,03479029 0,04499544 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,03479029 0,04496389 ! energy reserve metabolic process GO:0006112 28 27 0,000 0,03479029 0,04493238 ! learning or memory GO:0007611 28 27 0,000 0,03479029 0,04490092 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,03479029 0,04486949 ! cAMP-mediated signaling GO:0019933 27 27 0,000 0,03479029 0,04483812 ! peptide metabolic process GO:0006518 29 27 0,000 0,03479029 0,04480678 ! activation of caspase activity GO:0006919 27 27 0,000 0,03479029 0,04477549 ! mesenchymal cell development GO:0014031 29 27 0,000 0,03479029 0,04474425 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! defense response to bacterium GO:0042742 27 27 0,000 0,03479029 0,04471305 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,03479029 0,04468189 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,03479029 0,04465077 ! cell growth GO:0016049 27 27 0,000 0,03479029 0,0446197 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,0360579 0,04621328 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! stress-activated protein kinase signaling pathway GO:0031098 28 28 0,000 0,0360579 0,04618117 GO:0007254|JNK cascade, ! neuromuscular process GO:0050905 28 28 0,000 0,0360579 0,0461491 ! carbohydrate transport GO:0008643 28 28 0,000 0,0360579 0,04611707 ! regulation of muscle contraction GO:0006937 28 28 0,000 0,0360579 0,04608509 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,0360579 0,04605315 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,0360579 0,04602126 ! histone modification GO:0016570 28 28 0,000 0,0360579 0,04598941 ! protein amino acid autophosphorylation GO:0046777 28 28 0,000 0,0360579 0,04595761 ! developmental growth GO:0048589 28 28 0,000 0,0360579 0,04592585 ! regulation of mast cell proliferation GO:0070666 28 28 0,000 0,0360579 0,04589413 ! cartilage development GO:0051216 29 28 0,000 0,0360579 0,04586246 ! positive regulation of cell cycle GO:0045787 29 29 0,000 0,03732402 0,04744011 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,03732402 0,04740742 ! viral reproductive process GO:0022415 29 29 0,000 0,03732402 0,04737477 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,03732402 0,04734217 ! leukocyte migration GO:0050900 30 29 0,000 0,03732402 0,04730961 ! regulation of epithelial cell proliferation GO:0050678 29 29 0,000 0,03732402 0,04727709 ! regulation of lymphocyte proliferation GO:0050670 29 29 0,000 0,03732402 0,04724462 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! antigen processing and presentation GO:0019882 29 29 0,000 0,03732402 0,04721219 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,03732402 0,04717981 ! tRNA processing GO:0008033 29 29 0,000 0,03732402 0,04714748 ! regulation of gene expression, epigenetic GO:0040029 29 29 0,000 0,03732402 0,04711518 ! covalent chromatin modification GO:0016569 29 29 0,000 0,03732402 0,04708293 ! adult behavior GO:0030534 30 29 0,000 0,03732402 0,04705073 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,03732402 0,04701857 ! positive regulation of protein transport GO:0051222 29 29 0,000 0,03732402 0,04698645 ! response to UV GO:0009411 29 29 0,000 0,03732402 0,04695438 ! transition metal ion transport GO:0000041 31 30 0,000 0,03858866 0,04851222 ! RNA catabolic process GO:0006401 30 30 0,000 0,03858866 0,04847915 ! response to reactive oxygen species GO:0000302 31 30 0,000 0,03858866 0,04844612 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,03858866 0,04841314 ! positive regulation of peptidase activity GO:0010952 30 30 0,000 0,03858866 0,04838021 GO:0043280|positive regulation of caspase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,03858866 0,04834732 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,03858866 0,04831448 ! activation of phospholipase C activity GO:0007202 30 30 0,000 0,03858866 0,04828168 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of response to external stimulus GO:0032103 30 30 0,000 0,03858866 0,04824892 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 0,000 0,03858866 0,04821621 ! response to temperature stimulus GO:0009266 30 30 0,000 0,03858866 0,04818354 ! regulation of ossification GO:0030278 30 30 0,000 0,03858866 0,04815092 ! vascular process in circulatory system GO:0003018 31 30 0,000 0,03858866 0,04811834 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,03858866 0,04808581 GO:0019724|B cell mediated immunity, ! regulation of inflammatory response GO:0050727 30 30 0,000 0,03858866 0,04805332 ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,03858866 0,04802087 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,03858866 0,04798847 ! regulation of translational initiation GO:0006446 31 31 0,000 0,03985183 0,04952591 ! membrane fusion GO:0006944 31 31 0,000 0,03985183 0,04949254 ! B cell activation GO:0042113 31 31 0,000 0,03985183 0,04945921 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,03985183 0,04942593 ! positive regulation of phospholipase activity GO:0010518 31 31 0,000 0,03985183 0,04939269 ! ion transmembrane transport GO:0034220 31 31 0,000 0,03985183 0,04935949 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,03985183 0,04932634 ! digestion GO:0007586 31 31 0,000 0,03985183 0,04929324 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,03985183 0,04926018 ! regulation of DNA replication GO:0006275 32 31 0,000 0,03985183 0,04922716 ! regulation of heart contraction GO:0008016 31 31 0,000 0,03985183 0,04919419 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,03985183 0,04916126 ! camera-type eye development GO:0043010 31 31 0,000 0,03985183 0,04912838 ! extracellular matrix organization GO:0030198 31 31 0,000 0,03985183 0,04909554 ! regulation of intracellular transport GO:0032386 31 31 0,000 0,03985183 0,04906274 ! regulation of myeloid cell differentiation GO:0045637 32 31 0,000 0,03985183 0,04902999 ! negative regulation of cell motion GO:0051271 31 31 0,000 0,03985183 0,04899728 ! negative regulation of cell growth GO:0030308 32 32 0,000 0,04111352 0,05051482 ! cell redox homeostasis GO:0045454 32 32 0,000 0,04111352 0,05048116 ! glucose catabolic process GO:0006007 32 32 0,000 0,04111352 0,05044755 ! lipid modification GO:0030258 32 32 0,000 0,04111352 0,05041399 ! regulation of phospholipase activity GO:0010517 32 32 0,000 0,04111352 0,05038047 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,04111352 0,05034699 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,04111352 0,05031356 ! cell maturation GO:0048469 32 32 0,000 0,04111352 0,05028018 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 0,000 0,04111352 0,05024683 ! nuclear export GO:0051168 32 32 0,000 0,04111352 0,05021354 ! regulation of lymphocyte differentiation GO:0045619 32 32 0,000 0,04111352 0,05018028 ! positive regulation of lipase activity GO:0060193 32 32 0,000 0,04111352 0,05014707 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,04111352 0,05011391 ! maintenance of location GO:0051235 33 32 0,000 0,04111352 0,05008078 ! negative regulation of cell size GO:0045792 33 33 0,000 0,04237374 0,05158178 ! regulation of cellular response to stress GO:0080135 35 33 0,000 0,04237374 0,05154773 ! amino acid transport GO:0006865 33 33 0,000 0,04237374 0,05151373 ! activation of protein kinase activity GO:0032147 35 33 0,000 0,04237374 0,05147977 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,04237374 0,05144586 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,04237374 0,05141199 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,04237374 0,05137816 ! regulation of neuron apoptosis GO:0043523 34 33 0,000 0,04237374 0,05134438 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,04237374 0,05131065 ! regulation of actin filament length GO:0030832 34 34 0,000 0,04363249 0,05280018 ! regulation of angiogenesis GO:0045765 35 34 0,000 0,04363249 0,05276554 ! regulation of bone remodeling GO:0046850 34 34 0,000 0,04363249 0,05273094 ! response to metal ion GO:0010038 34 34 0,000 0,04363249 0,05269638 ! muscle cell differentiation GO:0042692 35 34 0,000 0,04363249 0,05266187 ! cellular polysaccharide metabolic process GO:0044264 35 34 0,000 0,04363249 0,05262741 ! regulation of protein catabolic process GO:0042176 35 34 0,000 0,04363249 0,05259299 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,04363249 0,05255861 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,04363249 0,05252428 ! regulation of lipid metabolic process GO:0019216 34 34 0,000 0,04363249 0,05249 ! secondary metabolic process GO:0019748 34 34 0,000 0,04363249 0,05245576 ! response to peptide hormone stimulus GO:0043434 36 34 0,000 0,04363249 0,05242156 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,04363249 0,05238741 ! viral reproduction GO:0016032 34 34 0,000 0,04363249 0,05235331 ! detection of stimulus GO:0051606 36 34 0,000 0,04363249 0,05231924 ! acute inflammatory response GO:0002526 35 35 0,000 0,04488977 0,05379183 ! regulation of cellular component size GO:0032535 35 35 0,000 0,04488977 0,05375688 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,04488977 0,05372197 ! mesoderm development GO:0007498 35 35 0,000 0,04488977 0,05368711 ! multicellular organism reproduction GO:0032504 36 35 0,000 0,04488977 0,05365229 GO:0048609|reproductive process in a multicellular organism, ! regulation of cell morphogenesis GO:0022604 38 35 0,000 0,04488977 0,05361752 ! positive regulation of phosphorylation GO:0042327 35 35 0,000 0,04488977 0,0535828 ! regulation of tissue remodeling GO:0034103 35 35 0,000 0,04488977 0,05354811 ! inorganic anion transport GO:0015698 35 35 0,000 0,04488977 0,05351348 ! response to steroid hormone stimulus GO:0048545 35 35 0,000 0,04488977 0,05347889 ! regulation of immune effector process GO:0002697 35 35 0,000 0,04488977 0,05344434 ! hydrogen transport GO:0006818 36 36 0,000 0,04614557 0,05490399 GO:0015992|proton transport, ! response to inorganic substance GO:0010035 36 36 0,000 0,04614557 0,05486857 ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,04614557 0,0548332 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 0,000 0,04614557 0,05479787 ! regulation of mitosis GO:0007088 37 36 0,000 0,04614557 0,05476258 GO:0051783|regulation of nuclear division, ! positive regulation of cell migration GO:0030335 36 36 0,000 0,04614557 0,05472734 ! embryonic limb morphogenesis GO:0030326 36 36 0,000 0,04614557 0,05469215 GO:0035113|embryonic appendage morphogenesis, ! positive regulation of phosphorus metabolic process GO:0010562 36 36 0,000 0,04614557 0,054657 GO:0045937|positive regulation of phosphate metabolic process, ! female pregnancy GO:0007565 37 36 0,000 0,04614557 0,05462189 ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,04614557 0,05458683 ! positive regulation of organelle organization GO:0010638 36 36 0,000 0,04614557 0,05455182 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,04614557 0,05451685 ! integrin-mediated signaling pathway GO:0007229 36 36 0,000 0,04614557 0,05448193 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,04614557 0,05444705 ! gonad development GO:0008406 36 36 0,000 0,04614557 0,05441221 ! regulation of lipase activity GO:0060191 36 36 0,000 0,04614557 0,05437742 ! activation of immune response GO:0002253 36 36 0,000 0,04614557 0,05434268 ! coagulation GO:0050817 39 36 0,000 0,04614557 0,05430797 GO:0007596|blood coagulation, ! regulation of adenylate cyclase activity GO:0045761 37 37 0,000 0,04739991 0,05574859 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! meiosis GO:0007126 37 37 0,000 0,04739991 0,05571303 GO:0051327|M phase of meiotic cell cycle, ! response to drug GO:0042493 37 37 0,000 0,04739991 0,05567752 ! lung development GO:0030324 38 37 0,000 0,04739991 0,05564206 ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,04739991 0,05560664 ! eye development GO:0001654 37 37 0,000 0,04739991 0,05557127 ! negative regulation of growth GO:0045926 37 37 0,000 0,04739991 0,05553594 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,04739991 0,05550066 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,04739991 0,05546542 ! regulation of Rho protein signal transduction GO:0035023 37 37 0,000 0,04739991 0,05543022 ! adaptive immune response GO:0002250 37 37 0,000 0,04739991 0,05539507 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of secretion GO:0051047 39 38 0,000 0,04865278 0,05682324 ! neurotransmitter transport GO:0006836 40 38 0,000 0,04865278 0,05678725 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,04865278 0,05675131 ! exocytosis GO:0006887 40 38 0,000 0,04865278 0,05671542 ! cell-matrix adhesion GO:0007160 39 38 0,000 0,04865278 0,05667957 ! chromosome segregation GO:0007059 38 38 0,000 0,04865278 0,05664376 ! hexose catabolic process GO:0019320 38 38 0,000 0,04865278 0,056608 ! RNA elongation GO:0006354 38 38 0,000 0,04865278 0,05657229 ! meiotic cell cycle GO:0051321 38 38 0,000 0,04865278 0,05653662 ! axon guidance GO:0007411 39 38 0,000 0,04865278 0,05650099 ! regulation of neurological system process GO:0031644 38 38 0,000 0,04865278 0,05646541 ! steroid hormone receptor signaling pathway GO:0030518 38 38 0,000 0,04865278 0,05642988 ! regulation of homeostatic process GO:0032844 38 38 0,000 0,04865278 0,05639439 ! regulation of cAMP biosynthetic process GO:0030817 39 39 0,000 0,04990419 0,05780856 ! hemostasis GO:0007599 42 39 0,000 0,04990419 0,05777225 ! positive regulation of protein modification process GO:0031401 39 39 0,000 0,04990419 0,05773598 ! activation of MAPK activity GO:0000187 39 39 0,000 0,04990419 0,05769976 ! respiratory tube development GO:0030323 40 39 0,000 0,04990419 0,05766359 ! response to unfolded protein GO:0006986 39 39 0,000 0,04990419 0,05762745 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,04990419 0,05759137 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,04990419 0,05755533 ! nucleotide-excision repair GO:0006289 40 39 0,000 0,04990419 0,05751934 ! cytokine-mediated signaling pathway GO:0019221 39 39 0,000 0,04990419 0,05748339 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,04990419 0,05744748 ! regulation of MAPKKK cascade GO:0043408 41 39 0,000 0,04990419 0,05741162 ! positive regulation of T cell activation GO:0050870 39 39 0,000 0,04990419 0,05737581 ! respiratory system development GO:0060541 40 39 0,000 0,04990419 0,05734004 ! developmental maturation GO:0021700 39 39 0,000 0,04990419 0,05730431 ! lymphocyte differentiation GO:0030098 39 39 0,000 0,04990419 0,05726863 ! limb development GO:0060173 39 39 0,000 0,04990419 0,05723299 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! protein oligomerization GO:0051259 39 39 0,000 0,04990419 0,0571974 ! positive regulation of cell motion GO:0051272 39 39 0,000 0,04990419 0,05716185 ! regulation of cAMP metabolic process GO:0030814 40 40 0,000 0,05115413 0,05855718 ! DNA catabolic process GO:0006308 41 40 0,000 0,05115413 0,05852083 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 0,000 0,05115413 0,05848453 ! myeloid cell differentiation GO:0030099 42 40 0,000 0,05115413 0,05844827 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 0,000 0,05240261 0,05983768 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! cell cycle checkpoint GO:0000075 42 41 0,000 0,05240261 0,05980063 ! amine catabolic process GO:0009310 42 41 0,000 0,05240261 0,05976362 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,05240261 0,05972666 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,05240261 0,05968975 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,05240261 0,05965288 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,05240261 0,05961606 ! monosaccharide catabolic process GO:0046365 41 41 0,000 0,05240261 0,05957928 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,05364963 0,06095948 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 0,000 0,05364963 0,06092192 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,05364963 0,06088441 ! cell-substrate adhesion GO:0031589 43 42 0,000 0,05364963 0,06084694 ! development of primary sexual characteristics GO:0045137 42 42 0,000 0,05364963 0,06080952 ! protein ubiquitination GO:0016567 43 42 0,000 0,05364963 0,06077214 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,05364963 0,06073481 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! response to protein stimulus GO:0051789 42 42 0,000 0,05364963 0,06069753 ! forebrain development GO:0030900 43 42 0,000 0,05364963 0,06066029 ! one-carbon metabolic process GO:0006730 42 42 0,000 0,05364963 0,0606231 ! reproductive structure development GO:0048608 43 43 0,000 0,0548952 0,06199255 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 0,000 0,0548952 0,06195459 ! alcohol catabolic process GO:0046164 43 43 0,000 0,0548952 0,06191667 ! homeostasis of number of cells GO:0048872 44 43 0,000 0,0548952 0,0618788 ! regulation of nucleotide metabolic process GO:0006140 43 43 0,000 0,0548952 0,06184098 ! humoral immune response GO:0006959 44 44 0,000 0,0561393 0,06320387 ! mRNA transport GO:0051028 44 44 0,000 0,0561393 0,06316528 ! protein import into nucleus GO:0006606 44 44 0,000 0,0561393 0,06312674 ! vitamin metabolic process GO:0006766 44 44 0,000 0,0561393 0,06308825 ! positive regulation of lymphocyte activation GO:0051251 44 44 0,000 0,0561393 0,06304981 ! amine biosynthetic process GO:0009309 46 45 0,000 0,05738195 0,06440617 ! homophilic cell adhesion GO:0007156 45 45 0,000 0,05738195 0,06436697 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,05738195 0,06432782 ! phosphoinositide-mediated signaling GO:0048015 45 45 0,000 0,05738195 0,06428871 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,05738195 0,06424965 ! nuclear import GO:0051170 45 45 0,000 0,05738195 0,06421064 ! Wnt receptor signaling pathway GO:0016055 46 45 0,000 0,05738195 0,06417168 ! protein processing GO:0016485 45 45 0,000 0,05738195 0,06413277 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,05862314 0,06548027 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 0,000 0,05862314 0,06544061 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,05862314 0,065401 ! cellular response to hormone stimulus GO:0032870 48 46 0,000 0,05862314 0,06536144 ! regulation of membrane potential GO:0042391 46 46 0,000 0,05862314 0,06532192 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,05986288 0,06666302 ! regulation of blood pressure GO:0008217 48 47 0,000 0,05986288 0,06662276 ! sex differentiation GO:0007548 47 47 0,000 0,05986288 0,06658256 ! amine transport GO:0015837 47 47 0,000 0,05986288 0,0665424 ! rhythmic process GO:0048511 47 47 0,000 0,05986288 0,06650229 ! regulation of catabolic process GO:0009894 48 47 0,000 0,05986288 0,06646223 ! calcium ion transport GO:0006816 48 48 0,000 0,06110117 0,06779619 ! actin filament organization GO:0007015 50 48 0,000 0,06110117 0,06775539 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,06110117 0,06771465 ! protein localization in nucleus GO:0034504 48 48 0,000 0,06110117 0,06767396 ! DNA recombination GO:0006310 48 48 0,000 0,06110117 0,06763331 ! leukocyte differentiation GO:0002521 50 49 0,000 0,06233801 0,06896096 ! ossification GO:0001503 50 49 0,000 0,06233801 0,06891959 GO:0060348|bone development, ! cell cycle arrest GO:0007050 49 49 0,000 0,06233801 0,06887827 ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,06233801 0,068837 ! divalent metal ion transport GO:0070838 49 49 0,000 0,06233801 0,06879578 ! response to nutrient GO:0007584 49 49 0,000 0,06233801 0,06875461 ! response to bacterium GO:0009617 50 49 0,000 0,06233801 0,06871349 ! positive regulation of MAP kinase activity GO:0043406 50 49 0,000 0,06233801 0,06867242 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,06233801 0,0686314 ! positive regulation of cell activation GO:0050867 49 49 0,000 0,06233801 0,06859042 GO:0002696|positive regulation of leukocyte activation, ! regulation of defense response GO:0031347 50 50 0,000 0,06357341 0,06990799 ! regulation of DNA metabolic process GO:0051052 51 50 0,000 0,06357341 0,0698663 ! negative regulation of transport GO:0051051 51 50 0,000 0,06357341 0,06982466 ! RNA transport GO:0050658 50 50 0,000 0,06357341 0,06978308 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! T cell activation GO:0042110 51 50 0,000 0,06357341 0,06974154 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 0,000 0,06357341 0,06970005 ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,06357341 0,06965861 ! transcription initiation GO:0006352 50 50 0,000 0,06357341 0,06961722 ! anatomical structure homeostasis GO:0060249 51 50 0,000 0,06357341 0,06957588 ! anterior/posterior pattern formation GO:0009952 51 50 0,000 0,06357341 0,06953459 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,06480735 0,0708422 ! protein modification by small protein conjugation GO:0032446 52 51 0,000 0,06480735 0,0708002 ! positive regulation of immune response GO:0050778 51 51 0,000 0,06480735 0,07075826 ! rRNA metabolic process GO:0016072 51 51 0,000 0,06480735 0,07071637 GO:0006364|rRNA processing, ! interphase of mitotic cell cycle GO:0051329 52 51 0,000 0,06480735 0,07067452 GO:0051325|interphase, ! ATP biosynthetic process GO:0006754 51 51 0,000 0,06480735 0,07063273 ! protein maturation GO:0051604 51 51 0,000 0,06480735 0,07059098 ! RNA localization GO:0006403 52 52 0,000 0,06603985 0,07189099 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,06603985 0,07184855 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 0,000 0,06603985 0,07180616 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,06603985 0,07176382 ! regulation of body fluid levels GO:0050878 55 52 0,000 0,06603985 0,07172153 ! response to light stimulus GO:0009416 53 52 0,000 0,06603985 0,07167929 ! sodium ion transport GO:0006814 53 53 0,000 0,0672709 0,0729725 ! tRNA metabolic process GO:0006399 53 53 0,000 0,0672709 0,07292957 ! response to hypoxia GO:0001666 53 53 0,000 0,0672709 0,0728867 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 0,000 0,0672709 0,07284387 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,0672709 0,0728011 ! carbohydrate catabolic process GO:0016052 53 53 0,000 0,0672709 0,07275838 ! regulation of T cell activation GO:0050863 53 53 0,000 0,0672709 0,0727157 ! regulation of protein transport GO:0051223 53 53 0,000 0,0672709 0,07267308 GO:0070201|regulation of establishment of protein localization, ! protein amino acid dephosphorylation GO:0006470 55 54 0,000 0,06850051 0,07395808 ! response to oxygen levels GO:0070482 55 54 0,000 0,06850051 0,07391478 ! response to virus GO:0009615 54 54 0,000 0,06850051 0,07387153 ! hormone metabolic process GO:0042445 55 54 0,000 0,06850051 0,07382833 ! sulfur metabolic process GO:0006790 55 54 0,000 0,06850051 0,07378518 ! negative regulation of multicellular organismal process GO:0051241 55 54 0,000 0,06850051 0,07374208 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,06972869 0,07502041 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! in utero embryonic development GO:0001701 55 55 0,000 0,06972869 0,07497664 ! regulation of cell adhesion GO:0030155 56 55 0,000 0,06972869 0,07493293 ! protein modification by small protein conjugation or removal GO:0070647 56 55 0,000 0,06972869 0,07488926 ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,07095542 0,0761624 ! reproductive developmental process GO:0003006 56 56 0,000 0,07095542 0,07611806 ! extracellular structure organization GO:0043062 56 56 0,000 0,07095542 0,07607378 ! ATP metabolic process GO:0046034 57 57 0,000 0,07218071 0,07734247 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,07218071 0,07729753 ! regulation of protein localization GO:0032880 58 57 0,000 0,07218071 0,07725264 ! innate immune response GO:0045087 58 58 0,000 0,07340457 0,0785169 ! dephosphorylation GO:0016311 60 59 0,000 0,07462699 0,07977816 ! carboxylic acid transport GO:0046942 59 59 0,000 0,07462699 0,07973191 GO:0015849|organic acid transport, ! peptidyl-amino acid modification GO:0018193 61 59 0,000 0,07462699 0,07968571 ! sterol metabolic process GO:0016125 59 59 0,000 0,07462699 0,07963957 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,07462699 0,07959348 ! protein localization in organelle GO:0033365 59 59 0,000 0,07462699 0,07954745 ! immune effector process GO:0002252 59 59 0,000 0,07462699 0,07950147 ! potassium ion transport GO:0006813 60 60 0,000 0,07584798 0,08075553 ! protein polymerization GO:0051258 65 60 0,000 0,07584798 0,0807089 ! cellular respiration GO:0045333 62 61 0,000 0,07706753 0,0819593 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 0,000 0,07706753 0,08191203 ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,07706753 0,08186482 GO:0016054|organic acid catabolic process, ! positive regulation of cellular protein metabolic process GO:0032270 61 61 0,000 0,07706753 0,08181766 ! lipid transport GO:0006869 62 62 0,000 0,07828566 0,08306302 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,07828566 0,08301523 ! axonogenesis GO:0007409 66 62 0,000 0,07828566 0,08296749 ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,07828566 0,08291981 ! protein import GO:0017038 62 62 0,000 0,07828566 0,08287218 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,07828566 0,08282461 ! regulation of lymphocyte activation GO:0051249 62 62 0,000 0,07828566 0,08277709 ! regulation of secretion GO:0051046 65 63 0,000 0,07950235 0,08401539 ! glucose metabolic process GO:0006006 63 63 0,000 0,07950235 0,08396724 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,07950235 0,08391915 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,07950235 0,08387111 ! glycerolipid metabolic process GO:0046486 65 64 0,000 0,08071762 0,08510445 ! regulation of response to external stimulus GO:0032101 65 64 0,000 0,08071762 0,08505579 ! angiogenesis GO:0001525 65 64 0,000 0,08071762 0,08500718 ! positive regulation of protein metabolic process GO:0051247 64 64 0,000 0,08071762 0,08495864 ! anion transport GO:0006820 65 65 0,000 0,08193146 0,08618703 ! positive regulation of cellular component organization GO:0051130 65 65 0,000 0,08193146 0,08613787 ! regulation of hormone levels GO:0010817 66 65 0,000 0,08193146 0,08608876 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,08314388 0,08731291 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,08314388 0,08726319 ! regulation of MAP kinase activity GO:0043405 67 66 0,000 0,08314388 0,08721353 ! polysaccharide metabolic process GO:0005976 69 66 0,000 0,08314388 0,08716392 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 0,000 0,08435487 0,08838319 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! muscle contraction GO:0006936 67 67 0,000 0,08435487 0,08833297 ! negative regulation of cell differentiation GO:0045596 68 67 0,000 0,08435487 0,08828281 ! Ras protein signal transduction GO:0007265 69 67 0,000 0,08435487 0,0882327 ! response to radiation GO:0009314 70 68 0,000 0,08556444 0,08944712 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,08556444 0,08939641 ! regulation of translation GO:0006417 69 69 0,000 0,08677259 0,0906073 ! regionalization GO:0003002 70 69 0,000 0,08677259 0,09055599 ! response to nutrient levels GO:0031667 69 69 0,000 0,08677259 0,09050475 ! regulation of leukocyte activation GO:0002694 69 69 0,000 0,08677259 0,09045355 ! regulation of mitotic cell cycle GO:0007346 72 69 0,000 0,08677259 0,09040242 ! positive regulation of transport GO:0051050 71 70 0,000 0,08797932 0,09160785 ! cell part morphogenesis GO:0032990 75 70 0,000 0,08797932 0,09155612 ! wound healing GO:0042060 74 70 0,000 0,08797932 0,09150445 ! growth GO:0040007 70 70 0,000 0,08797932 0,09145284 ! carboxylic acid biosynthetic process GO:0046394 70 70 0,000 0,08797932 0,09140129 GO:0016053|organic acid biosynthetic process, ! translational elongation GO:0006414 71 71 0,000 0,08918464 0,09260129 ! oxidative phosphorylation GO:0006119 71 71 0,000 0,08918464 0,09254915 ! regulation of cell migration GO:0030334 71 71 0,000 0,08918464 0,09249706 ! calcium ion homeostasis GO:0055074 71 71 0,000 0,08918464 0,09244504 GO:0006874|cellular calcium ion homeostasis, ! regulation of cell activation GO:0050865 71 71 0,000 0,08918464 0,09239308 ! secretion by cell GO:0032940 75 72 0,000 0,09038853 0,09358768 ! muscle system process GO:0003012 72 72 0,000 0,09038853 0,09353513 ! positive regulation of hydrolase activity GO:0051345 72 72 0,000 0,09038853 0,09348264 ! response to extracellular stimulus GO:0009991 72 72 0,000 0,09038853 0,09343021 ! regulation of cytokine production GO:0001817 72 72 0,000 0,09038853 0,09337784 ! electron transport chain GO:0022900 75 74 0,000 0,09279209 0,09580718 ! coenzyme metabolic process GO:0006732 75 74 0,000 0,09279209 0,09575354 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,09399174 0,0969372 ! response to oxidative stress GO:0006979 76 75 0,000 0,09399174 0,09688299 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,09399174 0,09682883 ! positive regulation of multicellular organismal process GO:0051240 76 76 0,000 0,09518999 0,09800847 ! cellular metal ion homeostasis GO:0006875 77 77 0,000 0,09638683 0,09918533 ! cell morphogenesis involved in differentiation GO:0000904 82 77 0,000 0,09638683 0,09912998 ! regulation of protein modification process GO:0031399 79 78 0,000 0,09758226 0,10030346 ! microtubule-based movement GO:0007018 82 78 0,000 0,09758226 0,10024755 ! positive regulation of protein kinase cascade GO:0010740 79 78 0,000 0,09758226 0,1001917 ! metal ion homeostasis GO:0055065 78 78 0,000 0,09758226 0,10013592 ! regulation of immune response GO:0050776 78 78 0,000 0,09758226 0,10008019 ! regulation of locomotion GO:0040012 79 79 0,000 0,09877629 0,10124844 ! regulation of cell motion GO:0051270 79 79 0,000 0,09877629 0,10119216 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,09996891 0,10235705 ! neuron projection development GO:0031175 85 80 0,000 0,09996891 0,10230022 ! MAPKKK cascade GO:0000165 82 81 0,000 0,10116012 0,10346177 ! lymphocyte activation GO:0046649 82 81 0,000 0,10116012 0,10340439 ! lipid catabolic process GO:0016042 82 81 0,000 0,10116012 0,10334707 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,10353836 0,10571811 ! ncRNA processing GO:0034470 83 83 0,000 0,10353836 0,10565957 ! blood vessel morphogenesis GO:0048514 84 83 0,000 0,10353836 0,1056011 ! cellular amino acid derivative metabolic process GO:0006575 87 84 0,000 0,10472537 0,10675269 ! regulation of cellular localization GO:0060341 86 85 0,000 0,10591099 0,10790158 ! nitrogen compound biosynthetic process GO:0044271 86 85 0,000 0,10591099 0,10784197 ! positive regulation of cell differentiation GO:0045597 87 85 0,000 0,10591099 0,10778242 ! positive regulation of response to stimulus GO:0048584 86 85 0,000 0,10591099 0,10772294 ! positive regulation of protein kinase activity GO:0045860 89 86 0,000 0,10709522 0,10886734 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 0,000 0,10709522 0,10880732 ! organophosphate metabolic process GO:0019637 87 86 0,000 0,10709522 0,10874737 GO:0006644|phospholipid metabolic process, ! hexose metabolic process GO:0019318 87 86 0,000 0,10709522 0,10868749 ! heart development GO:0007507 90 87 0,000 0,10827805 0,10982743 ! male gamete generation GO:0048232 90 88 0,000 0,10945948 0,1109647 GO:0007283|spermatogenesis, ! positive regulation of transferase activity GO:0051347 91 88 0,000 0,10945948 0,1109037 GO:0033674|positive regulation of kinase activity, ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,10945948 0,11084276 ! chemotaxis GO:0006935 90 89 0,000 0,11063953 0,11197619 GO:0042330|taxis, ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 0,000 0,11063953 0,11191474 ! regulation of Ras protein signal transduction GO:0046578 90 90 0,000 0,11181818 0,11304493 ! brain development GO:0007420 91 90 0,000 0,11181818 0,11298296 ! negative regulation of cell cycle GO:0045786 92 91 0,000 0,11299545 0,11410992 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 0,000 0,11299545 0,11404743 ! visual perception GO:0007601 93 92 0,000 0,11417133 0,11517119 GO:0050953|sensory perception of light stimulus, ! fatty acid metabolic process GO:0006631 93 92 0,000 0,11417133 0,11510818 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 0,000 0,11417133 0,11504525 ! positive regulation of immune system process GO:0002684 92 92 0,000 0,11417133 0,11498238 ! regulation of response to stress GO:0080134 97 94 0,000 0,11651893 0,11728257 ! blood vessel development GO:0001568 95 94 0,000 0,11651893 0,11721855 ! cofactor metabolic process GO:0051186 95 94 0,000 0,11651893 0,1171546 ! vasculature development GO:0001944 97 96 0,000 0,118861 0,11944429 ! endocytosis GO:0006897 99 98 0,000 0,12119755 0,12172593 GO:0010324|membrane invagination, ! posttranscriptional regulation of gene expression GO:0010608 98 98 0,000 0,12119755 0,12165963 ! glycoprotein metabolic process GO:0009100 99 98 0,000 0,12119755 0,1215934 ! blood circulation GO:0008015 99 98 0,000 0,12119755 0,12152725 GO:0003013|circulatory system process, ! regulation of system process GO:0044057 98 98 0,000 0,12119755 0,12146116 ! response to hormone stimulus GO:0009725 102 100 0,000 0,12352859 0,12372999 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 0,000 0,12352859 0,12366278 ! response to other organism GO:0051707 101 100 0,000 0,12352859 0,12359565 ! hemopoiesis GO:0030097 104 100 0,000 0,12352859 0,12352859