pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a1/out-0.05-06-0.01-300-run-a1//th1-pval-1e-02-02-th2-pval-1e-01-11-th3-pval-1e-01-01-run-a1/go_data/6119-7-real-Parker_GPL887-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/GPL887.an.zip classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! cyclin-dependent protein kinase holoenzyme complex GO:0000307 8 8 2,000 4,298E-09 1,568E-05 ! cyclin-dependent protein kinase regulator activity GO:0016538 14 14 2,000 2,79E-08 5,088E-05 ! nucleotide-excision repair, DNA damage removal GO:0000718 22 21 2,000 1,018E-07 1,237E-04 ! G1/S transition of mitotic cell cycle GO:0000082 54 43 2,000 9,392E-07 8,565E-04 ! RNA elongation from RNA polymerase II promoter GO:0006368 49 44 2,000 1,008E-06 7,352E-04 ! response to UV GO:0009411 59 45 2,000 1,079E-06 6,563E-04 ! RNA elongation GO:0006354 52 47 2,000 1,233E-06 6,425E-04 ! nucleotide-excision repair GO:0006289 53 49 2,000 1,4E-06 6,384E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 55 51 2,000 1,582E-06 6,412E-04 ! DNA catabolic process GO:0006308 57 53 2,000 1,779E-06 6,488E-04 ! origin recognition complex GO:0000808 5 5 1,000 2,053E-06 6,809E-04 ! RNA polymerase II carboxy-terminal domain kinase activity GO:0008353 5 5 1,000 2,053E-06 6,242E-04 ! transcription initiation from RNA polymerase II promoter GO:0006367 69 61 2,000 2,727E-06 7,653E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 6 6 1,000 3,079E-06 8,023E-04 ! DNA replication origin binding GO:0003688 6 6 1,000 3,079E-06 7,488E-04 ! DNA replication factor A complex GO:0005662 7 6 1,000 3,079E-06 7,02E-04 ! protein kinase regulator activity GO:0019887 74 66 2,000 3,463E-06 7,432E-04 ! nuclear chromosome part GO:0044454 94 70 2,000 4,139E-06 8,388E-04 ! holo TFIIH complex GO:0005675 7 7 1,000 4,309E-06 8,274E-04 ! transcription initiation GO:0006352 84 75 2,000 5,099E-06 9,301E-04 ! kinase regulator activity GO:0019207 93 76 2,000 5,308E-06 9,22E-04 ! interphase of mitotic cell cycle GO:0051329 100 81 2,000 6,434E-06 1,067E-03 ! interphase GO:0051325 103 83 2,000 6,925E-06 1,098E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 12 10 1,000 9,228E-06 1,403E-03 ! cyclin-dependent protein kinase inhibitor activity GO:0004861 10 10 1,000 9,228E-06 1,346E-03 ! positive regulation of B cell proliferation GO:0030890 15 11 1,000 1,128E-05 1,582E-03 ! nuclear chromosome GO:0000228 127 100 2,000 1,214E-05 1,64E-03 ! response to light stimulus GO:0009416 131 100 2,000 1,214E-05 1,581E-03 ! thymus development GO:0048538 13 12 1,000 1,353E-05 1,702E-03 ! midbody GO:0030496 14 12 1,000 1,353E-05 1,645E-03 ! replisome GO:0030894 24 13 1,000 1,598E-05 1,881E-03 GO:0043601|nuclear replisome, ! DNA unwinding during replication GO:0006268 14 13 1,000 1,598E-05 1,822E-03 ! T cell homeostasis GO:0043029 14 13 1,000 1,598E-05 1,767E-03 ! negative regulation of microtubule depolymerization GO:0007026 16 14 1,000 1,864E-05 2E-03 GO:0031114|regulation of microtubule depolymerization, ! regulation of B cell proliferation GO:0030888 18 14 1,000 1,864E-05 1,943E-03 ! nuclear replication fork GO:0043596 26 15 1,000 2,15E-05 2,179E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 17 15 1,000 2,15E-05 2,12E-03 ! DNA replication initiation GO:0006270 15 15 1,000 2,15E-05 2,064E-03 ! DNA duplex unwinding GO:0032508 17 16 1,000 2,457E-05 2,298E-03 GO:0032392|DNA geometric change, ! protein serine/threonine kinase inhibitor activity GO:0030291 17 16 1,000 2,457E-05 2,241E-03 ! lymphocyte homeostasis GO:0002260 17 16 1,000 2,457E-05 2,186E-03 ! G2/M transition of mitotic cell cycle GO:0000086 22 16 1,000 2,457E-05 2,134E-03 ! nucleotide-excision repair, DNA gap filling GO:0006297 19 16 1,000 2,457E-05 2,084E-03 ! spindle microtubule GO:0005876 27 18 1,000 3,131E-05 2,596E-03 ! cellular response to unfolded protein GO:0034620 21 19 1,000 3,499E-05 2,836E-03 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of microtubule polymerization or depolymerization GO:0031110 21 19 1,000 3,499E-05 2,775E-03 ! positive regulation of fibroblast proliferation GO:0048146 25 19 1,000 3,499E-05 2,716E-03 ! leukocyte homeostasis GO:0001776 22 21 1,000 4,294E-05 3,264E-03 ! positive regulation of B cell activation GO:0050871 26 22 1,000 4,723E-05 3,516E-03 ! regulation of microtubule cytoskeleton organization GO:0070507 35 24 1,000 5,64E-05 4,115E-03 ! regulation of fibroblast proliferation GO:0048145 32 26 1,000 6,638E-05 4,748E-03 ! response to endoplasmic reticulum stress GO:0034976 30 26 1,000 6,638E-05 4,657E-03 ! fat cell differentiation GO:0045444 30 27 1,000 7,167E-05 4,933E-03 ! cyclin-dependent protein kinase activity GO:0004693 28 27 1,000 7,167E-05 4,842E-03 ! negative regulation of phosphorylation GO:0042326 30 28 1,000 7,716E-05 5,118E-03 ! replication fork GO:0005657 42 29 1,000 8,286E-05 5,398E-03 ! ER-nuclear signaling pathway GO:0006984 32 29 1,000 8,286E-05 5,303E-03 ! regulation of microtubule-based process GO:0032886 41 30 1,000 8,876E-05 5,582E-03 ! negative regulation of phosphorus metabolic process GO:0010563 34 31 1,000 9,485E-05 5,865E-03 GO:0045936|negative regulation of phosphate metabolic process, ! response to calcium ion GO:0051592 34 31 1,000 9,485E-05 5,767E-03 ! regulation of B cell activation GO:0050864 40 34 1,000 1,144E-04 6,839E-03 ! protein kinase inhibitor activity GO:0004860 37 34 1,000 1,144E-04 6,728E-03 ! kinase inhibitor activity GO:0019210 47 35 1,000 1,213E-04 7,021E-03 ! cellular response to extracellular stimulus GO:0031668 37 36 1,000 1,284E-04 7,316E-03 ! positive regulation of mast cell proliferation GO:0070668 43 36 1,000 1,284E-04 7,204E-03 GO:0050671|positive regulation of lymphocyte proliferation, ! positive regulation of leukocyte proliferation GO:0070665 47 37 1,000 1,357E-04 7,498E-03 GO:0032946|positive regulation of mononuclear cell proliferation, ! negative regulation of protein complex disassembly GO:0043242 42 38 1,000 1,432E-04 7,794E-03 ! general RNA polymerase II transcription factor activity GO:0016251 43 38 1,000 1,432E-04 7,68E-03 ! DNA-directed RNA polymerase activity GO:0003899 49 38 1,000 1,432E-04 7,568E-03 GO:0034062|RNA polymerase activity, ! damaged DNA binding GO:0003684 51 40 1,000 1,588E-04 8,273E-03 ! induction of apoptosis by intracellular signals GO:0008629 56 41 1,000 1,669E-04 8,573E-03 ! positive regulation of cell cycle GO:0045787 56 43 1,000 1,837E-04 9,305E-03 ! single-stranded DNA binding GO:0003697 48 45 1,000 2,012E-04 0,01005666 ! regulation of protein complex disassembly GO:0043244 49 45 1,000 2,012E-04 9,921E-03 ! DNA-dependent DNA replication GO:0006261 66 45 1,000 2,012E-04 9,788E-03 ! protein N-terminus binding GO:0047485 57 48 1,000 2,291E-04 0,01099796 ! negative regulation of cytoskeleton organization GO:0051494 73 49 1,000 2,388E-04 0,01131422 ! regulation of mast cell proliferation GO:0070666 57 49 1,000 2,388E-04 0,01116917 ! regulation of lymphocyte proliferation GO:0050670 61 52 1,000 2,691E-04 0,01242509 ! regulation of leukocyte proliferation GO:0070663 65 53 1,000 2,796E-04 0,01274777 GO:0032944|regulation of mononuclear cell proliferation, ! homeostasis of number of cells GO:0048872 67 59 1,000 3,466E-04 0,01560953 ! DNA-directed RNA polymerase II, holoenzyme GO:0016591 62 59 1,000 3,466E-04 0,01541917 ! response to metal ion GO:0010038 65 60 1,000 3,585E-04 0,01575475 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 77 62 1,000 3,828E-04 0,0166231 ! positive regulation of protein amino acid phosphorylation GO:0001934 72 62 1,000 3,828E-04 0,01642753 ! negative regulation of cell growth GO:0030308 69 63 1,000 3,952E-04 0,01676468 ! negative regulation of protein kinase activity GO:0006469 78 64 1,000 4,079E-04 0,01710229 ! response to unfolded protein GO:0006986 66 64 1,000 4,079E-04 0,01690795 ! negative regulation of cell size GO:0045792 71 65 1,000 4,207E-04 0,0172444 ! positive regulation of lymphocyte activation GO:0051251 83 65 1,000 4,207E-04 0,01705279 ! response to inorganic substance GO:0010035 71 65 1,000 4,207E-04 0,0168654 ! negative regulation of kinase activity GO:0033673 79 65 1,000 4,207E-04 0,01668208 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 80 65 1,000 4,207E-04 0,0165027 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 83 67 1,000 4,47E-04 0,01734678 ! negative regulation of organelle organization GO:0010639 93 68 1,000 4,604E-04 0,0176799 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 84 68 1,000 4,604E-04 0,01749573 ! nucleosome assembly GO:0006334 87 69 1,000 4,74E-04 0,01782779 ! positive regulation of ligase activity GO:0051351 86 70 1,000 4,879E-04 0,01816034 ! negative regulation of transferase activity GO:0051348 85 70 1,000 4,879E-04 0,01797691 ! chromatin assembly GO:0031497 88 70 1,000 4,879E-04 0,01779714 ! positive regulation of phosphorylation GO:0042327 82 70 1,000 4,879E-04 0,01762093 ! response to protein stimulus GO:0051789 73 70 1,000 4,879E-04 0,01744817 ! positive regulation of phosphorus metabolic process GO:0010562 85 72 1,000 5,161E-04 0,01827847 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of leukocyte activation GO:0002696 92 73 1,000 5,305E-04 0,01860801 ! protein-DNA complex assembly GO:0065004 101 74 1,000 5,451E-04 0,01893803 ! positive regulation of cell activation GO:0050867 94 75 1,000 5,599E-04 0,01926852 ! regulation of ubiquitin-protein ligase activity GO:0051438 92 75 1,000 5,599E-04 0,01908844 ! negative regulation of growth GO:0045926 85 76 1,000 5,749E-04 0,01941798 ! protein-DNA complex GO:0032993 93 76 1,000 5,749E-04 0,01923983 ! nucleosome organization GO:0034728 96 77 1,000 5,901E-04 0,01956844 ! regulation of ligase activity GO:0051340 95 78 1,000 6,054E-04 0,0198975 ! positive regulation of protein modification process GO:0031401 100 78 1,000 6,054E-04 0,01971984 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 101 83 1,000 6,852E-04 0,02212116 GO:0010498|proteasomal protein catabolic process, ! protein kinase binding GO:0019901 115 89 1,000 7,873E-04 0,02519486 ! spindle GO:0005819 126 92 1,000 8,41E-04 0,02667782 ! structure-specific DNA binding GO:0043566 112 92 1,000 8,41E-04 0,02644784 ! translation factor activity, nucleic acid binding GO:0008135 108 92 1,000 8,41E-04 0,02622179 ! cell cycle arrest GO:0007050 103 93 1,000 8,593E-04 0,02656436 ! regulation of cytoskeleton organization GO:0051493 133 93 1,000 8,593E-04 0,02634113 ! DNA packaging GO:0006323 113 94 1,000 8,777E-04 0,02668282 ! in utero embryonic development GO:0001701 110 96 1,000 9,152E-04 0,02759275 ! microtubule associated complex GO:0005875 135 97 1,000 9,343E-04 0,02793574 ! negative regulation of cellular component organization GO:0051129 132 99 1,000 9,729E-04 0,0288547 ! regulation of lymphocyte activation GO:0051249 123 100 1,000 9,925E-04 0,02919883 ! positive regulation of epidermal growth factor receptor activity GO:0045741 6 5 0,000 2,402E-03 0,0700939 ! negative regulation of S phase of mitotic cell cycle GO:0045749 5 5 0,000 2,402E-03 0,0695376 ! positive regulation of fatty acid biosynthetic process GO:0045723 5 5 0,000 2,402E-03 0,06899006 ! positive regulation of tumor necrosis factor biosynthetic process GO:0042535 6 5 0,000 2,402E-03 0,06845108 ! response to superoxide GO:0000303 5 5 0,000 2,402E-03 0,06792045 ! negative regulation of small GTPase mediated signal transduction GO:0051058 6 5 0,000 2,402E-03 0,06739799 GO:0046580|negative regulation of Ras protein signal transduction, ! regulation of interferon-alpha production GO:0032647 6 5 0,000 2,402E-03 0,0668835 GO:0032479|regulation of type I interferon production, ! regulation of hormone biosynthetic process GO:0046885 5 5 0,000 2,402E-03 0,0663768 ! calcium:cation antiporter activity GO:0015368 5 5 0,000 2,402E-03 0,06587773 ! quinolinate metabolic process GO:0046874 5 5 0,000 2,402E-03 0,06538611 ! biotin binding GO:0009374 7 5 0,000 2,402E-03 0,06490176 ! secondary active monocarboxylate transmembrane transporter activity GO:0015355 6 5 0,000 2,402E-03 0,06442454 ! tongue development GO:0043586 6 5 0,000 2,402E-03 0,06395429 ! nose development GO:0043584 5 5 0,000 2,402E-03 0,06349086 ! cell proliferation in forebrain GO:0021846 5 5 0,000 2,402E-03 0,06303409 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 5 5 0,000 2,402E-03 0,06258384 ! sodium-dependent phosphate transmembrane transporter activity GO:0015321 6 5 0,000 2,402E-03 0,06213999 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 7 5 0,000 2,402E-03 0,06170238 ! drug:hydrogen antiporter activity GO:0015307 6 5 0,000 2,402E-03 0,0612709 GO:0015520|tetracycline:hydrogen antiporter activity, GO:0015904|tetracycline transport, ! nuclear mRNA 3'-splice site recognition GO:0000389 6 5 0,000 2,402E-03 0,0608454 ! glycolipid transport GO:0046836 6 5 0,000 2,402E-03 0,06042578 ! phospholipid:diacylglycerol acyltransferase activity GO:0046027 6 5 0,000 2,402E-03 0,0600119 ! regulation of respiratory gaseous exchange GO:0043576 6 5 0,000 2,402E-03 0,05960366 ! regulation of protein export from nucleus GO:0046825 5 5 0,000 2,402E-03 0,05920093 ! neuron adhesion GO:0007158 5 5 0,000 2,402E-03 0,05880361 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 5 5 0,000 2,402E-03 0,05841159 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GO:0046912 6 5 0,000 2,402E-03 0,05802476 ! opioid peptide activity GO:0001515 6 5 0,000 2,402E-03 0,05764301 ! selenocysteine incorporation GO:0001514 5 5 0,000 2,402E-03 0,05726626 GO:0006451|translational readthrough, ! mRNA stabilization GO:0048255 6 5 0,000 2,402E-03 0,0568944 GO:0043489|RNA stabilization, ! N-acetylglucosamine 6-O-sulfotransferase activity GO:0001517 8 5 0,000 2,402E-03 0,05652734 ! cardiac muscle cell proliferation GO:0060038 6 5 0,000 2,402E-03 0,05616499 GO:0014855|striated muscle cell proliferation, ! dsRNA fragmentation GO:0031050 6 5 0,000 2,402E-03 0,05580725 GO:0035196|gene silencing by miRNA, production of miRNAs, GO:0035195|gene silencing by miRNA, ! ruffle membrane GO:0032587 6 5 0,000 2,402E-03 0,05545404 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 2,402E-03 0,05510527 ! negative regulation of receptor-mediated endocytosis GO:0048261 7 5 0,000 2,402E-03 0,05476086 ! clathrin coat assembly GO:0048268 6 5 0,000 2,402E-03 0,05442073 ! cerebral cortex cell migration GO:0021795 5 5 0,000 2,402E-03 0,0540848 ! eukaryotic translation elongation factor 1 complex GO:0005853 5 5 0,000 2,402E-03 0,05375299 ! membrane hyperpolarization GO:0060081 5 5 0,000 2,402E-03 0,05342523 ! regulation of striated muscle cell differentiation GO:0051153 6 5 0,000 2,402E-03 0,05310144 ! regulation of smooth muscle cell differentiation GO:0051150 5 5 0,000 2,402E-03 0,05278155 ! translation repressor activity GO:0030371 8 5 0,000 2,402E-03 0,0524655 ! positive regulation of muscle cell differentiation GO:0051149 6 5 0,000 2,402E-03 0,0521532 ! smooth muscle cell differentiation GO:0051145 6 5 0,000 2,402E-03 0,0518446 ! chaperone-mediated protein complex assembly GO:0051131 5 5 0,000 2,402E-03 0,05153964 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 5 5 0,000 2,402E-03 0,05123823 ! negative regulation of stress-activated protein kinase signaling pathway GO:0070303 6 5 0,000 2,402E-03 0,05094034 GO:0046329|negative regulation of JNK cascade, ! double-stranded telomeric DNA binding GO:0003691 6 5 0,000 2,402E-03 0,05064588 ! negative regulation of heart contraction GO:0045822 5 5 0,000 2,402E-03 0,05035482 ! N-acetylgalactosamine 4-O-sulfotransferase activity GO:0001537 5 5 0,000 2,402E-03 0,05006707 ! microfibril GO:0001527 5 5 0,000 2,402E-03 0,0497826 ! troponin I binding GO:0031013 5 5 0,000 2,402E-03 0,04950135 ! negative regulation of viral genome replication GO:0045071 6 5 0,000 2,402E-03 0,04922325 ! traversing start control point of mitotic cell cycle GO:0007089 6 5 0,000 2,402E-03 0,04894826 ! positive regulation of interleukin-12 biosynthetic process GO:0045084 5 5 0,000 2,402E-03 0,04867632 ! dorsal/ventral neural tube patterning GO:0021904 5 5 0,000 2,402E-03 0,04840739 ! dermatan sulfate proteoglycan metabolic process GO:0050655 5 5 0,000 2,402E-03 0,04814142 ! protein lipoylation GO:0009249 14 5 0,000 2,402E-03 0,04787835 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 2,402E-03 0,04761814 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 5 5 0,000 2,402E-03 0,04736075 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! regulation of isotype switching to IgG isotypes GO:0048302 5 5 0,000 2,402E-03 0,04710612 ! transmembrane-ephrin receptor activity GO:0005005 6 5 0,000 2,402E-03 0,04685421 ! mitochondrion localization, microtubule-mediated GO:0034643 5 5 0,000 2,402E-03 0,04660499 GO:0047497|mitochondrion transport along microtubule, GO:0051654|establishment of mitochondrion localization, ! vasopressin receptor activity GO:0005000 5 5 0,000 2,402E-03 0,0463584 ! glutamate catabolic process GO:0006538 6 5 0,000 2,402E-03 0,04611441 ! microvillus organization GO:0032528 5 5 0,000 2,402E-03 0,04587297 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 6 5 0,000 2,402E-03 0,04563405 ! tyrosine catabolic process GO:0006572 5 5 0,000 2,402E-03 0,04539761 ! response to pH GO:0009268 5 5 0,000 2,402E-03 0,0451636 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 6 5 0,000 2,402E-03 0,04493199 ! regulation of protein import into nucleus, translocation GO:0033158 5 5 0,000 2,402E-03 0,04470275 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor GO:0016670 5 5 0,000 2,402E-03 0,04447583 ! polyol biosynthetic process GO:0046173 5 5 0,000 2,402E-03 0,0442512 ! phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 7 5 0,000 2,402E-03 0,04402883 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 2,402E-03 0,04380869 ! fibroblast growth factor receptor activity GO:0005007 6 5 0,000 2,402E-03 0,04359074 ! protein-DNA loading ATPase activity GO:0033170 6 5 0,000 2,402E-03 0,04337494 GO:0003689|DNA clamp loader activity, ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) GO:0000276 5 5 0,000 2,402E-03 0,04316127 ! anaerobic glycolysis GO:0019642 5 5 0,000 2,402E-03 0,0429497 GO:0004459|L-lactate dehydrogenase activity, ! adenosine receptor activity, G-protein coupled GO:0001609 6 5 0,000 2,402E-03 0,04274019 ! regulation of retinoic acid receptor signaling pathway GO:0048385 6 5 0,000 2,402E-03 0,04253271 ! peroxisomal matrix GO:0005782 5 5 0,000 2,402E-03 0,04232724 GO:0031907|microbody lumen, ! regulation of angiotensin levels in blood GO:0002002 5 5 0,000 2,402E-03 0,04212374 GO:0060177|regulation of angiotensin metabolic process, ! vacuolar lumen GO:0005775 6 5 0,000 2,402E-03 0,04192219 ! morphogenesis of an epithelial sheet GO:0002011 5 5 0,000 2,402E-03 0,04172256 ! multivesicular body GO:0005771 5 5 0,000 2,402E-03 0,04152483 ! regulation of phospholipase A2 activity GO:0032429 5 5 0,000 2,402E-03 0,04132895 GO:0032430|positive regulation of phospholipase A2 activity, ! paraxial mesoderm formation GO:0048341 6 5 0,000 2,402E-03 0,04113492 ! insulin-like growth factor I binding GO:0031994 6 5 0,000 2,402E-03 0,0409427 ! mitochondrial outer membrane translocase complex GO:0005742 5 5 0,000 2,402E-03 0,04075227 ! peptidyl-histidine phosphorylation GO:0018106 6 5 0,000 2,402E-03 0,0405636 ! negative regulation of lipoprotein lipase activity GO:0051005 5 5 0,000 2,402E-03 0,04037667 ! epithelial cell maturation GO:0002070 14 5 0,000 2,402E-03 0,04019146 ! positive regulation of lipoprotein lipase activity GO:0051006 6 5 0,000 2,402E-03 0,04000794 ! muscle thin filament assembly GO:0030240 5 5 0,000 2,402E-03 0,03982608 ! regulation of protein amino acid autophosphorylation GO:0031952 5 5 0,000 2,402E-03 0,03964587 ! nitric-oxide synthase regulator activity GO:0030235 6 5 0,000 2,402E-03 0,03946729 ! negative regulation of fatty acid metabolic process GO:0045922 14 5 0,000 2,402E-03 0,03929031 ! regulation of glycoprotein biosynthetic process GO:0010559 6 5 0,000 2,402E-03 0,0391149 ! cellular glucose homeostasis GO:0001678 5 5 0,000 2,402E-03 0,03894106 ! positive regulation of translational initiation GO:0045948 6 5 0,000 2,402E-03 0,03876875 ! nonhomologous end joining complex GO:0070419 6 5 0,000 2,402E-03 0,03859797 GO:0005958|DNA-dependent protein kinase-DNA ligase 4 complex, ! depyrimidination GO:0045008 5 5 0,000 2,402E-03 0,03842868 ! regulation of chromatin assembly or disassembly GO:0001672 5 5 0,000 2,402E-03 0,03826087 ! ATPase activator activity GO:0001671 5 5 0,000 2,402E-03 0,03809451 ! phosphoinositide 5-phosphatase activity GO:0034595 5 5 0,000 2,402E-03 0,0379296 GO:0004439|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, ! DNA damage response, signal transduction resulting in transcription GO:0042772 17 5 0,000 2,402E-03 0,03776611 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! calcium sensitive guanylate cyclase activator activity GO:0008048 5 5 0,000 2,402E-03 0,03760403 ! regulation of cholesterol biosynthetic process GO:0045540 5 5 0,000 2,402E-03 0,03744333 ! positive regulation of collagen metabolic process GO:0010714 6 5 0,000 2,402E-03 0,03728399 GO:0032967|positive regulation of collagen biosynthetic process, ! phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0017176 7 5 0,000 2,402E-03 0,03712601 ! regulation of protein amino acid dephosphorylation GO:0035304 7 5 0,000 2,402E-03 0,03696936 ! cardiac myofibril assembly GO:0055003 5 5 0,000 2,402E-03 0,03681403 ! anterograde axon cargo transport GO:0008089 6 5 0,000 2,402E-03 0,03665999 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 2,402E-03 0,03650724 ! GPI-anchor transamidase complex GO:0042765 5 5 0,000 2,402E-03 0,03635576 GO:0003923|GPI-anchor transamidase activity, ! regulation of leukocyte degranulation GO:0043300 5 5 0,000 2,402E-03 0,03620553 ! thiamin and derivative metabolic process GO:0042723 5 5 0,000 2,402E-03 0,03605654 ! protein localization to telomere GO:0070198 7 5 0,000 2,402E-03 0,03590876 ! response to exogenous dsRNA GO:0043330 5 5 0,000 2,402E-03 0,0357622 ! MutSalpha complex binding GO:0032407 7 5 0,000 2,402E-03 0,03561682 ! bile acid biosynthetic process GO:0006699 5 5 0,000 2,402E-03 0,03547262 ! negative regulation of fat cell differentiation GO:0045599 6 5 0,000 2,402E-03 0,03532959 ! enucleate erythrocyte differentiation GO:0043353 7 5 0,000 2,402E-03 0,0351877 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 2,402E-03 0,03504695 ! nerve growth factor binding GO:0048406 7 5 0,000 2,402E-03 0,03490732 ! platelet-derived growth factor binding GO:0048407 8 5 0,000 2,402E-03 0,0347688 ! high-density lipoprotein binding GO:0008035 6 5 0,000 2,402E-03 0,03463138 ! negative regulation of focal adhesion formation GO:0051895 5 5 0,000 2,402E-03 0,03449503 ! transcription initiation factor activity GO:0016986 5 5 0,000 2,402E-03 0,03435976 ! gas homeostasis GO:0033483 5 5 0,000 2,402E-03 0,03422554 ! Schwann cell development GO:0014044 5 5 0,000 2,402E-03 0,03409237 ! CD4-positive, alpha beta T cell differentiation GO:0043367 5 5 0,000 2,402E-03 0,03396023 ! cyclohydrolase activity GO:0019238 5 5 0,000 2,402E-03 0,0338291 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 2,402E-03 0,03369899 ! response to pheromone GO:0019236 5 5 0,000 2,402E-03 0,03356988 GO:0016503|pheromone receptor activity, ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 5 5 0,000 2,402E-03 0,03344175 ! phosphatidylserine metabolic process GO:0006658 5 5 0,000 2,402E-03 0,03331459 ! rhombomere development GO:0021546 6 5 0,000 2,402E-03 0,0331884 ! alanine transport GO:0032328 6 5 0,000 2,402E-03 0,03306316 ! superoxide-generating NADPH oxidase activity GO:0016175 5 5 0,000 2,402E-03 0,03293887 ! NAD(P)H oxidase activity GO:0016174 5 5 0,000 2,402E-03 0,0328155 ! ventral spinal cord interneuron specification GO:0021521 7 5 0,000 2,402E-03 0,03269305 GO:0021514|ventral spinal cord interneuron differentiation, GO:0060579|ventral spinal cord interneuron fate commitment, ! spinal cord motor neuron cell fate specification GO:0021520 6 5 0,000 2,402E-03 0,03257152 ! regulation of meiosis GO:0040020 6 5 0,000 2,402E-03 0,03245088 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 6 5 0,000 2,402E-03 0,03233114 GO:0000085|G2 phase of mitotic cell cycle, ! parasympathetic nervous system development GO:0048486 5 5 0,000 2,402E-03 0,03221227 ! lymphocyte costimulation GO:0031294 5 5 0,000 2,402E-03 0,03209428 GO:0031295|T cell costimulation, ! response to tumor cell GO:0002347 7 5 0,000 2,402E-03 0,03197715 ! RS domain binding GO:0050733 6 5 0,000 2,402E-03 0,03186087 ! telomerase holoenzyme complex GO:0005697 6 5 0,000 2,402E-03 0,03174543 ! negative regulation of lipoprotein metabolic process GO:0050748 6 5 0,000 2,402E-03 0,03163082 ! B cell homeostasis GO:0001782 6 5 0,000 2,402E-03 0,03151704 ! positive regulation of Wnt receptor signaling pathway GO:0030177 5 5 0,000 2,402E-03 0,03140408 ! anaphase GO:0051322 7 5 0,000 2,402E-03 0,03129192 GO:0000090|mitotic anaphase, ! S phase GO:0051320 5 5 0,000 2,402E-03 0,03118056 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of blood coagulation GO:0030194 6 5 0,000 2,402E-03 0,03106999 GO:0050820|positive regulation of coagulation, ! ribonuclease H activity GO:0004523 14 5 0,000 2,402E-03 0,03096021 ! AP-2 adaptor complex GO:0030122 5 5 0,000 2,402E-03 0,03085119 GO:0030128|clathrin coat of endocytic vesicle, ! lipase activator activity GO:0060229 6 5 0,000 2,402E-03 0,03074294 ! diuresis GO:0030146 5 5 0,000 2,402E-03 0,03063545 GO:0030147|natriuresis, ! phosphatidylcholine binding GO:0031210 5 5 0,000 2,402E-03 0,0305287 ! DNA-methyltransferase activity GO:0009008 5 5 0,000 2,402E-03 0,0304227 ! structural constituent of nuclear pore GO:0017056 5 5 0,000 2,402E-03 0,03031743 ! very-low-density lipoprotein particle clearance GO:0034447 6 5 0,000 2,402E-03 0,03021289 ! GTP-Rho binding GO:0017049 5 5 0,000 2,402E-03 0,03010907 ! glucocorticoid biosynthetic process GO:0006704 5 5 0,000 2,402E-03 0,03000595 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 2,402E-03 0,02990354 ! chondroitin sulfotransferase activity GO:0034481 6 5 0,000 2,402E-03 0,02980183 ! brown fat cell differentiation GO:0050873 5 5 0,000 2,402E-03 0,02970081 ! regulation of telomerase activity GO:0051972 6 5 0,000 2,402E-03 0,02960047 ! quaternary ammonium group transmembrane transporter activity GO:0015651 5 5 0,000 2,402E-03 0,0295008 ! TAP complex GO:0042825 5 5 0,000 2,402E-03 0,02940181 ! platelet dense granule GO:0042827 6 5 0,000 2,402E-03 0,02930347 ! bHLH transcription factor binding GO:0043425 5 5 0,000 2,402E-03 0,02920579 ! secretory granule organization GO:0033363 5 5 0,000 2,402E-03 0,02910876 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters GO:0016888 14 5 0,000 2,402E-03 0,02901238 ! ligase activity, forming phosphoric ester bonds GO:0016886 5 5 0,000 2,402E-03 0,02891663 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 2,402E-03 0,02882151 ! lamin binding GO:0005521 8 5 0,000 2,402E-03 0,02872701 ! aldehyde-lyase activity GO:0016832 6 5 0,000 2,402E-03 0,02863313 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 2,402E-03 0,02853986 ! neural plate morphogenesis GO:0001839 6 5 0,000 2,402E-03 0,0284472 ! cyclosporin A binding GO:0016018 6 5 0,000 2,402E-03 0,02835514 ! peptidoglycan receptor activity GO:0016019 5 5 0,000 2,402E-03 0,02826367 ! negative regulation of fibrinolysis GO:0051918 5 5 0,000 2,402E-03 0,02817279 ! positive regulation of telomere maintenance GO:0032206 7 5 0,000 2,402E-03 0,02808249 ! pattern recognition receptor signaling pathway GO:0002221 5 5 0,000 2,402E-03 0,02799277 GO:0002224|toll-like receptor signaling pathway, ! phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 5 5 0,000 2,402E-03 0,02790362 ! positive regulation of blood vessel endothelial cell migration GO:0043536 6 5 0,000 2,402E-03 0,02781504 ! flavin-containing monooxygenase activity GO:0004499 6 5 0,000 2,402E-03 0,02772702 ! regulation of calcium ion transport via store-operated calcium channel activity GO:0032234 5 5 0,000 2,402E-03 0,02763955 ! hemopoietic progenitor cell differentiation GO:0002244 6 5 0,000 2,402E-03 0,02755264 ! organ or tissue specific immune response GO:0002251 6 5 0,000 2,402E-03 0,02746626 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 7 5 0,000 2,402E-03 0,02738043 ! retina homeostasis GO:0001895 5 5 0,000 2,402E-03 0,02729513 ! prepulse inhibition GO:0060134 8 5 0,000 2,402E-03 0,02721037 ! maternal placenta development GO:0001893 5 5 0,000 2,402E-03 0,02712612 GO:0046697|decidualization, ! endothelial cell development GO:0001885 6 5 0,000 2,402E-03 0,0270424 ! regulation of growth hormone secretion GO:0060123 5 5 0,000 2,402E-03 0,02695919 GO:0060124|positive regulation of growth hormone secretion, ! isocitrate dehydrogenase activity GO:0004448 5 5 0,000 2,402E-03 0,0268765 ! thiamin pyrophosphate binding GO:0030976 5 5 0,000 2,402E-03 0,02679431 ! protein palmitoylation GO:0018345 5 5 0,000 2,402E-03 0,02671262 ! protein amino acid prenylation GO:0018346 6 5 0,000 2,402E-03 0,02663142 ! N-methyl-D-aspartate selective glutamate receptor complex GO:0017146 8 5 0,000 2,402E-03 0,02655072 ! stem cell division GO:0017145 6 5 0,000 2,402E-03 0,02647051 GO:0048103|somatic stem cell division, ! fibroblast growth factor binding GO:0017134 5 5 0,000 2,402E-03 0,02639078 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 6 5 0,000 2,402E-03 0,02631153 ! organ regeneration GO:0031100 6 5 0,000 2,402E-03 0,02623275 ! lymphocyte apoptosis GO:0070227 6 5 0,000 2,402E-03 0,02615444 ! positive regulation of microtubule polymerization GO:0031116 5 5 0,000 2,402E-03 0,0260766 ! negative regulation of nucleotide biosynthetic process GO:0030809 6 5 0,000 2,402E-03 0,02599922 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of developmental growth GO:0048639 6 5 0,000 2,402E-03 0,0259223 ! acyl carrier activity GO:0000036 5 5 0,000 2,402E-03 0,02584584 ! positive regulation of cAMP biosynthetic process GO:0030819 6 5 0,000 2,402E-03 0,02576982 GO:0030816|positive regulation of cAMP metabolic process, ! condensin complex GO:0000796 6 5 0,000 2,402E-03 0,02569425 ! phagocytic vesicle GO:0045335 5 5 0,000 2,402E-03 0,02561912 ! blood coagulation, extrinsic pathway GO:0007598 5 5 0,000 2,402E-03 0,02554443 ! regulation of cGMP biosynthetic process GO:0030826 5 5 0,000 2,402E-03 0,02547017 GO:0030823|regulation of cGMP metabolic process, ! citrulline metabolic process GO:0000052 14 5 0,000 2,402E-03 0,02539634 ! positive regulation of actin filament polymerization GO:0030838 5 5 0,000 2,402E-03 0,02532294 ! polyol transport GO:0015791 8 5 0,000 2,402E-03 0,02524997 ! post-embryonic morphogenesis GO:0009886 7 5 0,000 2,402E-03 0,02517741 ! pyrimidine nucleotide-sugar transport GO:0015781 5 5 0,000 2,402E-03 0,02510527 ! regulation of cell adhesion mediated by integrin GO:0033628 5 5 0,000 2,402E-03 0,02503354 ! cell adhesion mediated by integrin GO:0033627 5 5 0,000 2,402E-03 0,02496222 ! short-chain fatty acid metabolic process GO:0046459 6 5 0,000 2,402E-03 0,0248913 ! glycerol-3-phosphate metabolic process GO:0006072 6 5 0,000 2,402E-03 0,02482079 ! ethanol metabolic process GO:0006067 6 5 0,000 2,402E-03 0,02475067 GO:0006069|ethanol oxidation, GO:0034308|monohydric alcohol metabolic process, ! phosphatidic acid metabolic process GO:0046473 5 5 0,000 2,402E-03 0,02468095 ! cobalt ion transport GO:0006824 5 5 0,000 2,402E-03 0,02461162 ! cellular zinc ion homeostasis GO:0006882 6 5 0,000 2,402E-03 0,02454268 ! Golgi to plasma membrane transport GO:0006893 7 5 0,000 2,402E-03 0,02447413 ! syncytium formation by plasma membrane fusion GO:0000768 5 5 0,000 2,402E-03 0,02440596 GO:0007520|myoblast fusion, ! poly(U) RNA binding GO:0008266 5 5 0,000 2,402E-03 0,02433816 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 5 5 0,000 2,402E-03 0,02427074 ! sterol carrier activity GO:0005498 6 5 0,000 2,402E-03 0,0242037 ! adaptation of signaling pathway GO:0022401 6 5 0,000 2,402E-03 0,02413702 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! 2-oxoglutarate metabolic process GO:0006103 6 5 0,000 2,402E-03 0,02407071 ! response to acid GO:0001101 7 5 0,000 2,402E-03 0,02400476 ! fibril organization GO:0043206 5 5 0,000 2,402E-03 0,02393918 ! malate metabolic process GO:0006108 6 5 0,000 2,402E-03 0,02387395 ! regulation of dopamine uptake GO:0051584 7 5 0,000 2,402E-03 0,02380907 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! copulation GO:0007620 5 5 0,000 2,402E-03 0,02374455 ! circadian sleep/wake cycle process GO:0022410 5 5 0,000 2,402E-03 0,02368037 GO:0042749|regulation of circadian sleep/wake cycle, GO:0045187|regulation of circadian sleep/wake cycle, sleep, ! cleavage furrow GO:0032154 6 5 0,000 2,402E-03 0,02361654 ! protein maturation by protein folding GO:0022417 5 5 0,000 2,402E-03 0,02355306 ! activation of protein kinase B activity GO:0032148 15 5 0,000 2,402E-03 0,02348991 ! neurexin binding GO:0042043 6 5 0,000 2,402E-03 0,02342711 ! sensory perception of temperature stimulus GO:0050951 8 5 0,000 2,402E-03 0,02336463 ! protein amino acid dealkylation GO:0008214 5 5 0,000 2,402E-03 0,02330249 GO:0006482|protein amino acid demethylation, ! NF-kappaB-inducing kinase activity GO:0004704 5 5 0,000 2,402E-03 0,02324068 ! lipoic acid binding GO:0031405 5 5 0,000 2,402E-03 0,0231792 ! very-low-density lipoprotein particle assembly GO:0034379 5 5 0,000 2,402E-03 0,02311804 ! lithium ion binding GO:0031403 6 5 0,000 2,402E-03 0,02305721 ! grooming behavior GO:0007625 7 5 0,000 2,402E-03 0,02299669 ! regulation of smooth muscle cell apoptosis GO:0034391 5 5 0,000 2,402E-03 0,02293649 ! ribose phosphate diphosphokinase activity GO:0004749 6 5 0,000 2,402E-03 0,0228766 ! lymph vessel development GO:0001945 6 5 0,000 2,402E-03 0,02281703 ! bicarbonate transport GO:0015701 5 5 0,000 2,402E-03 0,02275776 ! positive regulation of cell-matrix adhesion GO:0001954 8 5 0,000 2,402E-03 0,0226988 GO:0010811|positive regulation of cell-substrate adhesion, ! response to interferon-gamma GO:0034341 6 5 0,000 2,402E-03 0,02264015 ! protein-lysine 6-oxidase activity GO:0004720 23 5 0,000 2,402E-03 0,0225818 ! endothelial cell proliferation GO:0001935 8 5 0,000 2,402E-03 0,02252375 ! polynucleotide adenylyltransferase activity GO:0004652 5 5 0,000 2,402E-03 0,022466 ! dorsal spinal cord development GO:0021516 6 5 0,000 2,402E-03 0,02240854 ! activation of MAPKKK activity GO:0000185 5 5 0,000 2,402E-03 0,02235137 ! synaptic vesicle maturation GO:0016188 6 5 0,000 2,402E-03 0,0222945 ! sphingoid catabolic process GO:0046521 5 5 0,000 2,402E-03 0,02223791 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 5 5 0,000 2,402E-03 0,02218162 ! neutrophil mediated immunity GO:0002446 5 5 0,000 2,402E-03 0,0221256 ! intercellular canaliculus GO:0046581 5 5 0,000 2,402E-03 0,02206987 ! dopamine binding GO:0035240 7 5 0,000 2,402E-03 0,02201442 GO:0004952|dopamine receptor activity, ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 5 5 0,000 2,402E-03 0,02195924 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 5 5 0,000 2,402E-03 0,02190435 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity GO:0003956 6 5 0,000 2,402E-03 0,02184972 ! amine oxidase activity GO:0008131 7 5 0,000 2,402E-03 0,02179537 ! monocyte activation GO:0042117 9 5 0,000 2,402E-03 0,02174129 ! negative regulation of protein binding GO:0032091 5 5 0,000 2,402E-03 0,02168747 ! regulation of response to food GO:0032095 5 5 0,000 2,402E-03 0,02163392 ! response to food GO:0032094 6 5 0,000 2,402E-03 0,02158064 ! positive regulation of protein binding GO:0032092 5 5 0,000 2,402E-03 0,02152761 ! copper ion transmembrane transporter activity GO:0005375 5 5 0,000 2,402E-03 0,02147485 ! regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 6 5 0,000 2,402E-03 0,02142234 ! hedgehog receptor activity GO:0008158 5 5 0,000 2,402E-03 0,02137009 ! lipoprotein catabolic process GO:0042159 5 5 0,000 2,402E-03 0,0213181 ! substrate-bound cell migration, cell extension GO:0006930 7 5 0,000 2,402E-03 0,02126635 ! purine salvage GO:0043101 7 5 0,000 2,402E-03 0,02121486 ! small-subunit processome GO:0032040 5 5 0,000 2,402E-03 0,02116362 ! positive regulation of catecholamine secretion GO:0033605 5 5 0,000 2,402E-03 0,02111262 ! ciliary rootlet GO:0035253 5 5 0,000 2,402E-03 0,02106187 ! myosin heavy chain binding GO:0032036 5 5 0,000 2,402E-03 0,02101136 ! nucleobase transport GO:0015851 5 5 0,000 2,402E-03 0,0209611 ! sodium ion transmembrane transporter activity GO:0015081 6 5 0,000 2,402E-03 0,02091107 ! GPI anchor binding GO:0034235 6 5 0,000 2,402E-03 0,02086128 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 2,402E-03 0,02081173 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! thrombin receptor activity GO:0015057 5 5 0,000 2,402E-03 0,02076241 ! palmitoyl-CoA hydrolase activity GO:0016290 5 5 0,000 2,402E-03 0,02071333 ! basic amino acid transport GO:0015802 5 5 0,000 2,402E-03 0,02066448 ! dendritic shaft GO:0043198 5 5 0,000 2,402E-03 0,02061585 ! terminal button GO:0043195 7 5 0,000 2,402E-03 0,02056746 ! arginine N-methyltransferase activity GO:0016273 6 5 0,000 2,402E-03 0,02051929 GO:0016274|protein-arginine N-methyltransferase activity, ! neuronal ion channel clustering GO:0045161 5 5 0,000 2,402E-03 0,02047135 ! transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 6 5 0,000 2,402E-03 0,02042363 ! homeostasis of number of cells within a tissue GO:0048873 7 5 0,000 2,402E-03 0,02037614 ! negative regulation of peptide secretion GO:0002792 5 5 0,000 2,402E-03 0,02032886 GO:0046676|negative regulation of insulin secretion, ! neural nucleus development GO:0048857 6 5 0,000 2,402E-03 0,0202818 ! response to UV-C GO:0010225 15 5 0,000 2,402E-03 0,02023496 ! positive regulation of organ growth GO:0046622 5 5 0,000 2,402E-03 0,02018834 ! response to arsenic GO:0046685 6 5 0,000 2,402E-03 0,02014193 ! IgE binding GO:0019863 5 5 0,000 2,402E-03 0,02009573 ! positive regulation of T cell cytokine production GO:0002726 5 5 0,000 2,402E-03 0,02004974 GO:0032743|positive regulation of interleukin-2 production, ! transcription-coupled nucleotide-excision repair GO:0006283 5 5 0,000 2,402E-03 0,02000397 ! monoamine transmembrane transporter activity GO:0008504 6 5 0,000 2,402E-03 0,0199584 ! response to copper ion GO:0046688 5 5 0,000 2,402E-03 0,01991304 ! response to cadmium ion GO:0046686 5 5 0,000 2,402E-03 0,01986789 ! tetrahydrofolate metabolic process GO:0046653 5 5 0,000 2,402E-03 0,01982294 ! regulation of interleukin-1 beta production GO:0032651 5 5 0,000 2,402E-03 0,01977819 ! protein autoprocessing GO:0016540 6 5 0,000 2,402E-03 0,01973364 ! intracellular cyclic nucleotide activated cation channel activity GO:0005221 5 5 0,000 2,402E-03 0,0196893 GO:0043855|cyclic nucleotide-gated ion channel activity, ! negative regulation of monooxygenase activity GO:0032769 5 5 0,000 2,402E-03 0,01964515 ! ryanodine-sensitive calcium-release channel activity GO:0005219 5 5 0,000 2,402E-03 0,0196012 GO:0005218|intracellular ligand-gated calcium channel activity, ! positive regulation of interleukin-10 production GO:0032733 5 5 0,000 2,402E-03 0,01955745 ! mitotic recombination GO:0006312 15 5 0,000 2,402E-03 0,01951389 ! negative regulation of interleukin-6 production GO:0032715 6 5 0,000 2,402E-03 0,01947053 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 2,402E-03 0,01942736 ! membrane to membrane docking GO:0022614 5 5 0,000 2,402E-03 0,01938438 ! regulation of transcription from RNA polymerase I promoter GO:0006356 14 5 0,000 2,402E-03 0,01934159 ! translation activator activity GO:0008494 5 5 0,000 2,402E-03 0,01929898 ! somatostatin receptor activity GO:0004994 5 5 0,000 2,402E-03 0,01925657 ! melanocortin receptor activity GO:0004977 6 5 0,000 2,402E-03 0,01921434 ! serine-type carboxypeptidase activity GO:0004185 5 5 0,000 2,402E-03 0,01917229 GO:0070008|serine-type exopeptidase activity, ! protein phosphatase 2A binding GO:0051721 6 5 0,000 2,402E-03 0,01913043 ! salivary gland morphogenesis GO:0007435 5 5 0,000 2,402E-03 0,01908875 ! galactosidase activity GO:0015925 5 5 0,000 2,402E-03 0,01904726 ! prostaglandin E receptor activity GO:0004957 7 5 0,000 2,402E-03 0,01900594 ! cellular response to nutrient GO:0031670 5 5 0,000 2,402E-03 0,0189648 ! ATP-dependent chromatin remodeling GO:0043044 5 5 0,000 2,402E-03 0,01892384 ! L-cystine transmembrane transporter activity GO:0015184 5 5 0,000 2,402E-03 0,01888306 ! glycine transmembrane transporter activity GO:0015187 7 5 0,000 2,402E-03 0,01884245 ! L-gamma-aminobutyric acid transmembrane transporter activity GO:0015185 6 5 0,000 2,402E-03 0,01880201 ! A band GO:0031672 5 5 0,000 2,402E-03 0,01876175 ! heat generation GO:0031649 5 5 0,000 2,402E-03 0,01872166 ! flagellum organization GO:0043064 5 5 0,000 2,402E-03 0,01868174 GO:0009296|flagellum assembly, ! tricarboxylic acid cycle enzyme complex GO:0045239 6 5 0,000 2,402E-03 0,018642 ! disaccharide metabolic process GO:0005984 6 5 0,000 2,402E-03 0,01860242 ! glycogen catabolic process GO:0005980 16 5 0,000 2,402E-03 0,018563 ! dopamine biosynthetic process GO:0042416 6 5 0,000 2,402E-03 0,01852376 ! 5'-3' exonuclease activity GO:0008409 14 5 0,000 2,402E-03 0,01848468 ! chromocenter GO:0010369 5 5 0,000 2,402E-03 0,01844576 ! glial cell migration GO:0008347 5 5 0,000 2,402E-03 0,01840701 ! epidermal growth factor receptor binding GO:0005154 7 5 0,000 2,402E-03 0,01836842 ! calcium-dependent phospholipase A2 activity GO:0047498 5 5 0,000 2,402E-03 0,01833 ! negative regulation of NF-kappaB import into nucleus GO:0042347 5 5 0,000 2,402E-03 0,01829173 ! growth hormone receptor binding GO:0005131 5 5 0,000 2,402E-03 0,01825362 ! protein serine/threonine phosphatase inhibitor activity GO:0004865 6 5 0,000 2,402E-03 0,01821567 ! negative regulation of smooth muscle contraction GO:0045986 7 5 0,000 2,402E-03 0,01817788 ! aminomethyltransferase activity GO:0004047 5 5 0,000 2,402E-03 0,01814024 ! aminoacylase activity GO:0004046 5 5 0,000 2,402E-03 0,01810276 ! penetration of zona pellucida GO:0007341 6 5 0,000 2,402E-03 0,01806544 ! alcohol dehydrogenase activity, zinc-dependent GO:0004024 5 5 0,000 2,402E-03 0,01802827 ! nucleus localization GO:0051647 5 5 0,000 2,402E-03 0,01799125 ! 3-chloroallyl aldehyde dehydrogenase activity GO:0004028 5 5 0,000 2,402E-03 0,01795438 ! carnitine metabolic process GO:0009437 5 5 0,000 2,402E-03 0,01791766 GO:0006577|betaine metabolic process, ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 2,882E-03 0,02145273 ! regulation of helicase activity GO:0051095 6 6 0,000 2,882E-03 0,02140904 ! response to oxygen radical GO:0000305 6 6 0,000 2,882E-03 0,02136553 ! positive regulation of axon extension GO:0045773 7 6 0,000 2,882E-03 0,02132219 ! forebrain neuron differentiation GO:0021879 6 6 0,000 2,882E-03 0,02127903 ! forebrain regionalization GO:0021871 7 6 0,000 2,882E-03 0,02123604 ! meiotic prophase I GO:0007128 7 6 0,000 2,882E-03 0,02119322 ! hydroxymethyl-, formyl- and related transferase activity GO:0016742 6 6 0,000 2,882E-03 0,02115058 ! inositol trisphosphate phosphatase activity GO:0046030 8 6 0,000 2,882E-03 0,02110811 GO:0004445|inositol-polyphosphate 5-phosphatase activity, ! regulation of lipid kinase activity GO:0043550 6 6 0,000 2,882E-03 0,02106581 ! SMAD protein nuclear translocation GO:0007184 7 6 0,000 2,882E-03 0,02102368 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 9 6 0,000 2,882E-03 0,02098172 ! carbohydrate phosphorylation GO:0046835 7 6 0,000 2,882E-03 0,02093992 ! phosphoinositide 3-kinase binding GO:0043548 6 6 0,000 2,882E-03 0,02089829 ! protein amino acid sulfation GO:0006477 9 6 0,000 2,882E-03 0,02085682 GO:0051923|sulfation, ! diphosphotransferase activity GO:0016778 7 6 0,000 2,882E-03 0,02081552 ! establishment of tissue polarity GO:0007164 8 6 0,000 2,882E-03 0,02077439 ! protein thiol-disulfide exchange GO:0006467 6 6 0,000 2,882E-03 0,02073341 ! receptor guanylyl cyclase signaling pathway GO:0007168 6 6 0,000 2,882E-03 0,0206926 ! embryonic camera-type eye development GO:0031076 9 6 0,000 2,882E-03 0,02065194 GO:0048596|embryonic camera-type eye morphogenesis, ! hexokinase activity GO:0004396 7 6 0,000 2,882E-03 0,02061145 ! regulation of mitochondrial membrane permeability GO:0046902 7 6 0,000 2,882E-03 0,02057111 ! neurofilament cytoskeleton organization GO:0060052 6 6 0,000 2,882E-03 0,02053094 ! Notch receptor processing GO:0007220 7 6 0,000 2,882E-03 0,02049091 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0016714 8 6 0,000 2,882E-03 0,02045105 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0016717 7 6 0,000 2,882E-03 0,02041134 ! eukaryotic translation initiation factor 2B complex GO:0005851 6 6 0,000 2,882E-03 0,02037178 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 6 0,000 2,882E-03 0,02033238 ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 6 0,000 2,882E-03 0,02029313 ! neurofilament GO:0005883 7 6 0,000 2,882E-03 0,02025403 ! glial cell fate commitment GO:0021781 7 6 0,000 2,882E-03 0,02021508 ! cytoplasmic dynein complex GO:0005868 7 6 0,000 2,882E-03 0,02017628 ! dynactin complex GO:0005869 7 6 0,000 2,882E-03 0,02013762 ! fibroblast growth factor receptor antagonist activity GO:0030353 7 6 0,000 2,882E-03 0,02009912 GO:0005152|interleukin-1 receptor antagonist activity, ! enoyl-CoA hydratase activity GO:0004300 6 6 0,000 2,882E-03 0,02006076 ! oocyte maturation GO:0001556 6 6 0,000 2,882E-03 0,02002255 ! reflex GO:0060004 10 6 0,000 2,882E-03 0,01998449 ! positive regulation of glycolysis GO:0045821 6 6 0,000 2,882E-03 0,01994656 ! parathyroid gland development GO:0060017 6 6 0,000 2,882E-03 0,01990879 ! anagen GO:0042640 7 6 0,000 2,882E-03 0,01987115 ! protein-cofactor linkage GO:0018065 15 6 0,000 2,882E-03 0,01983366 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 6 6 0,000 2,882E-03 0,01979631 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! protein targeting to ER GO:0045047 7 6 0,000 2,882E-03 0,0197591 GO:0006614|SRP-dependent cotranslational protein targeting to membrane, ! 3'-phosphoadenosine 5'-phosphosulfate binding GO:0050656 6 6 0,000 2,882E-03 0,01972202 ! skeletal myofibril assembly GO:0014866 6 6 0,000 2,882E-03 0,01968509 ! structural constituent of tooth enamel GO:0030345 7 6 0,000 2,882E-03 0,0196483 ! cysteine metabolic process GO:0006534 7 6 0,000 2,882E-03 0,01961164 ! glycine catabolic process GO:0006546 6 6 0,000 2,882E-03 0,01957512 ! adenohypophysis development GO:0021984 6 6 0,000 2,882E-03 0,01953873 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 6 6 0,000 2,882E-03 0,01950248 ! deoxyribonucleotide biosynthetic process GO:0009263 7 6 0,000 2,882E-03 0,01946637 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 6 0,000 2,882E-03 0,01943039 ! microtubule nucleation GO:0007020 7 6 0,000 2,882E-03 0,01939454 ! proline biosynthetic process GO:0006561 8 6 0,000 2,882E-03 0,01935882 ! tryptophan metabolic process GO:0006568 6 6 0,000 2,882E-03 0,01932323 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GO:0016671 6 6 0,000 2,882E-03 0,01928778 ! thyroid hormone generation GO:0006590 6 6 0,000 2,882E-03 0,01925245 ! melanin biosynthetic process from tyrosine GO:0006583 7 6 0,000 2,882E-03 0,01921726 ! retinoid X receptor binding GO:0046965 7 6 0,000 2,882E-03 0,01918219 ! proton-transporting V-type ATPase, V0 domain GO:0033179 6 6 0,000 2,882E-03 0,01914725 ! transforming growth factor beta receptor activity, type I GO:0005025 7 6 0,000 2,882E-03 0,01911244 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 2,882E-03 0,01907775 ! sister chromatid cohesion GO:0007062 6 6 0,000 2,882E-03 0,01904319 ! retinoic acid receptor signaling pathway GO:0048384 9 6 0,000 2,882E-03 0,01900875 ! positive regulation of transporter activity GO:0032411 8 6 0,000 2,882E-03 0,01897444 GO:0032414|positive regulation of ion transmembrane transporter activity, ! cerebral cortex neuron differentiation GO:0021895 7 6 0,000 2,882E-03 0,01894025 ! regulation of fatty acid beta-oxidation GO:0031998 6 6 0,000 2,882E-03 0,01890619 ! p53 binding GO:0002039 6 6 0,000 2,882E-03 0,01887224 ! demethylase activity GO:0032451 6 6 0,000 2,882E-03 0,01883842 ! positive regulation of nitric-oxide synthase activity GO:0051000 6 6 0,000 2,882E-03 0,01880472 ! regulation of platelet activation GO:0010543 7 6 0,000 2,882E-03 0,01877114 ! lipid phosphatase activity GO:0042577 7 6 0,000 2,882E-03 0,01873768 ! lens morphogenesis in camera-type eye GO:0002089 6 6 0,000 2,882E-03 0,01870434 ! guanylate cyclase activator activity GO:0030250 6 6 0,000 2,882E-03 0,01867112 GO:0010853|cyclase activator activity, ! negative regulation of carbohydrate metabolic process GO:0045912 8 6 0,000 2,882E-03 0,01863801 GO:0010677|negative regulation of cellular carbohydrate metabolic process, ! positive regulation of exocytosis GO:0045921 6 6 0,000 2,882E-03 0,01860503 ! protein tyrosine kinase activator activity GO:0030296 8 6 0,000 2,882E-03 0,01857215 ! protein import into mitochondrial inner membrane GO:0045039 7 6 0,000 2,882E-03 0,0185394 GO:0042719|mitochondrial intermembrane space protein transporter complex, ! positive regulation of steroid metabolic process GO:0045940 6 6 0,000 2,882E-03 0,01850676 ! LIM domain binding GO:0030274 7 6 0,000 2,882E-03 0,01847423 ! negative regulation of translational initiation GO:0045947 6 6 0,000 2,882E-03 0,01844182 ! positive regulation vascular endothelial growth factor production GO:0010575 6 6 0,000 2,882E-03 0,01840953 ! 5S class rRNA transcription GO:0042791 6 6 0,000 2,882E-03 0,01837734 GO:0042797|tRNA transcription from RNA polymerase III promoter, GO:0000127|transcription factor TFIIIC complex, ! integral to mitochondrial outer membrane GO:0031307 6 6 0,000 2,882E-03 0,01834527 ! axon guidance receptor activity GO:0008046 6 6 0,000 2,882E-03 0,01831331 ! zinc ion homeostasis GO:0055069 7 6 0,000 2,882E-03 0,01828146 ! positive regulation of gliogenesis GO:0014015 7 6 0,000 2,882E-03 0,01824972 GO:0045687|positive regulation of glial cell differentiation, ! centrosome duplication GO:0051298 7 6 0,000 2,882E-03 0,01821809 ! protein targeting to lysosome GO:0006622 6 6 0,000 2,882E-03 0,01818657 ! hyaluronan metabolic process GO:0030212 8 6 0,000 2,882E-03 0,01815516 ! protein retention in ER lumen GO:0006621 6 6 0,000 2,882E-03 0,01812386 ! ventricular cardiac muscle cell differentiation GO:0055012 8 6 0,000 2,882E-03 0,01809267 ! circadian sleep/wake cycle GO:0042745 7 6 0,000 2,882E-03 0,01806158 ! dynein binding GO:0045502 6 6 0,000 2,882E-03 0,0180306 ! regulation of dendrite development GO:0050773 6 6 0,000 2,882E-03 0,01799972 ! peptidyl-arginine modification GO:0018195 6 6 0,000 2,882E-03 0,01796896 ! eating behavior GO:0042755 7 6 0,000 2,882E-03 0,01793829 ! protein localization to chromosome GO:0034502 8 6 0,000 2,882E-03 0,01790773 ! Hsp90 protein binding GO:0051879 7 6 0,000 2,882E-03 0,01787728 ! glycolipid binding GO:0051861 7 6 0,000 2,882E-03 0,01784693 ! MutLalpha complex binding GO:0032405 8 6 0,000 2,882E-03 0,01781668 ! mast cell activation GO:0045576 6 6 0,000 2,882E-03 0,01778653 ! regulation of focal adhesion formation GO:0051893 6 6 0,000 2,882E-03 0,01775649 ! nucleoside catabolic process GO:0009164 7 6 0,000 2,882E-03 0,01772654 ! phosphatidylinositol biosynthetic process GO:0006661 6 6 0,000 2,882E-03 0,0176967 ! molybdopterin cofactor biosynthetic process GO:0032324 15 6 0,000 2,882E-03 0,01766696 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! negative regulation of multicellular organism growth GO:0040015 6 6 0,000 2,882E-03 0,01763731 ! RNA polymerase II transcription elongation factor activity GO:0016944 6 6 0,000 2,882E-03 0,01760777 ! lipoxygenase activity GO:0016165 6 6 0,000 2,882E-03 0,01757833 ! regulation of myeloid leukocyte mediated immunity GO:0002886 6 6 0,000 2,882E-03 0,01754898 ! alpha DNA polymerase:primase complex GO:0005658 16 6 0,000 2,882E-03 0,01751973 ! DNA-directed RNA polymerase III complex GO:0005666 6 6 0,000 2,882E-03 0,01749058 ! DNA replication factor C complex GO:0005663 7 6 0,000 2,882E-03 0,01746153 ! establishment of chromosome localization GO:0051303 15 6 0,000 2,882E-03 0,01743257 GO:0050000|chromosome localization, ! cilium morphogenesis GO:0060271 6 6 0,000 2,882E-03 0,01740371 ! nucleolar ribonuclease P complex GO:0005655 6 6 0,000 2,882E-03 0,01737494 GO:0030677|ribonuclease P complex, GO:0030681|multimeric ribonuclease P complex, ! intracellular lipid transport GO:0032365 6 6 0,000 2,882E-03 0,01734627 ! chromatin assembly complex GO:0005678 16 6 0,000 2,882E-03 0,01731769 ! sex chromatin GO:0001739 6 6 0,000 2,882E-03 0,01728921 GO:0000803|sex chromosome, ! morphogenesis of a polarized epithelium GO:0001738 7 6 0,000 2,882E-03 0,01726082 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 7 6 0,000 2,882E-03 0,01723252 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! SAP kinase activity GO:0016909 7 6 0,000 2,882E-03 0,01720432 ! regulation of inflammatory response to antigenic stimulus GO:0002861 6 6 0,000 2,882E-03 0,01717621 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 7 6 0,000 2,882E-03 0,01714819 ! positive regulation of pseudopodium assembly GO:0031274 6 6 0,000 2,882E-03 0,01712026 GO:0031272|regulation of pseudopodium assembly, ! regulation of lipoprotein metabolic process GO:0050746 7 6 0,000 2,882E-03 0,01709242 ! phosphatidylserine binding GO:0001786 6 6 0,000 2,882E-03 0,01706467 ! alpha-mannosidase activity GO:0004559 8 6 0,000 2,882E-03 0,01703702 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 6 0,000 2,882E-03 0,01700945 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 2,882E-03 0,01698197 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 11 6 0,000 2,882E-03 0,01695458 GO:0002820|negative regulation of adaptive immune response, ! myeloid dendritic cell activation GO:0001773 8 6 0,000 2,882E-03 0,01692728 GO:0043011|myeloid dendritic cell differentiation, ! immunological synapse GO:0001772 6 6 0,000 2,882E-03 0,01690006 ! leading edge membrane GO:0031256 8 6 0,000 2,882E-03 0,01687294 ! photoreceptor connecting cilium GO:0032391 7 6 0,000 2,882E-03 0,0168459 ! CARD domain binding GO:0050700 6 6 0,000 2,882E-03 0,01681894 ! regulation of muscle cell apoptosis GO:0010660 7 6 0,000 2,882E-03 0,01679208 ! COPII vesicle coat GO:0030127 7 6 0,000 2,882E-03 0,01676529 GO:0012507|ER to Golgi transport vesicle membrane, ! molybdenum ion binding GO:0030151 15 6 0,000 2,882E-03 0,0167386 ! glutathione biosynthetic process GO:0006750 7 6 0,000 2,882E-03 0,01671199 ! positive regulation of erythrocyte differentiation GO:0045648 8 6 0,000 2,882E-03 0,01668546 ! positive regulation of epidermis development GO:0045684 8 6 0,000 2,882E-03 0,01665902 ! proteasome regulator activity GO:0010860 6 6 0,000 2,882E-03 0,01663266 ! ceramidase activity GO:0017040 6 6 0,000 2,882E-03 0,01660638 ! antibiotic transport GO:0042891 7 6 0,000 2,882E-03 0,01658019 ! tetrahydrobiopterin biosynthetic process GO:0006729 7 6 0,000 2,882E-03 0,01655408 ! regulation of T-helper cell differentiation GO:0045622 6 6 0,000 2,882E-03 0,01652805 ! sodium channel regulator activity GO:0017080 6 6 0,000 2,882E-03 0,0165021 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 2,882E-03 0,01647624 ! regulation of protein homodimerization activity GO:0043496 9 6 0,000 2,882E-03 0,01645045 ! response to fluid shear stress GO:0034405 6 6 0,000 2,882E-03 0,01642475 ! lymph node development GO:0048535 6 6 0,000 2,882E-03 0,01639913 ! negative regulation of viral reproduction GO:0048525 7 6 0,000 2,882E-03 0,01637358 ! triglyceride catabolic process GO:0019433 15 6 0,000 2,882E-03 0,01634812 ! positive regulation of fatty acid oxidation GO:0046321 6 6 0,000 2,882E-03 0,01632273 ! ectodermal gut morphogenesis GO:0048567 7 6 0,000 2,882E-03 0,01629743 GO:0007439|ectodermal gut development, ! T cell activation during immune response GO:0002286 6 6 0,000 2,882E-03 0,0162722 ! negative regulation of lipase activity GO:0060192 6 6 0,000 2,882E-03 0,01624705 ! activation of innate immune response GO:0002218 6 6 0,000 2,882E-03 0,01622197 GO:0002758|innate immune response-activating signal transduction, ! regulation of telomere maintenance via telomerase GO:0032210 7 6 0,000 2,882E-03 0,01619698 ! sarcoglycan complex GO:0016012 8 6 0,000 2,882E-03 0,01617206 ! natural killer cell mediated immunity GO:0002228 7 6 0,000 2,882E-03 0,01614722 GO:0042267|natural killer cell mediated cytotoxicity, ! phosphatidylinositol-4,5-bisphosphate binding GO:0005546 6 6 0,000 2,882E-03 0,01612245 ! neural plate development GO:0001840 7 6 0,000 2,882E-03 0,01609776 ! regulation of synaptic transmission, GABAergic GO:0032228 15 6 0,000 2,882E-03 0,01607315 ! catecholamine transport GO:0051937 6 6 0,000 2,882E-03 0,01604861 ! ether hydrolase activity GO:0016803 7 6 0,000 2,882E-03 0,01602415 ! FACIT collagen GO:0005593 6 6 0,000 2,882E-03 0,01599976 ! lactate dehydrogenase activity GO:0004457 6 6 0,000 2,882E-03 0,01597544 ! regulation of T cell receptor signaling pathway GO:0050856 7 6 0,000 2,882E-03 0,0159512 ! collagen type IV GO:0005587 6 6 0,000 2,882E-03 0,01592703 ! negative regulation of DNA replication initiation GO:0032297 6 6 0,000 2,882E-03 0,01590293 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 7 6 0,000 2,882E-03 0,01587891 ! drug metabolic process GO:0017144 6 6 0,000 2,882E-03 0,01585496 ! extracellular matrix structural constituent conferring tensile strength GO:0030020 6 6 0,000 2,882E-03 0,01583108 ! negative regulation of synaptic transmission GO:0050805 6 6 0,000 2,882E-03 0,01580728 ! hyalurononglucosaminidase activity GO:0004415 6 6 0,000 2,882E-03 0,01578354 ! nucleoside-diphosphatase activity GO:0017110 6 6 0,000 2,882E-03 0,01575988 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 6 6 0,000 2,882E-03 0,01573629 ! regulation of microtubule polymerization GO:0031113 6 6 0,000 2,882E-03 0,01571276 ! cellular anion homeostasis GO:0030002 6 6 0,000 2,882E-03 0,01568931 GO:0055081|anion homeostasis, ! regulation of MHC class II biosynthetic process GO:0045346 6 6 0,000 2,882E-03 0,01566593 ! negative regulation of protein ubiquitination GO:0031397 7 6 0,000 2,882E-03 0,01564262 ! negative regulation of fibroblast proliferation GO:0048147 6 6 0,000 2,882E-03 0,01561937 ! behavioral response to cocaine GO:0048148 9 6 0,000 2,882E-03 0,0155962 ! translation initiation factor binding GO:0031369 6 6 0,000 2,882E-03 0,0155731 ! nucleotide-sugar transport GO:0015780 6 6 0,000 2,882E-03 0,01555006 ! sulfur amino acid transmembrane transporter activity GO:0000099 6 6 0,000 2,882E-03 0,01552709 ! virion attachment to host cell surface receptor GO:0019062 6 6 0,000 2,882E-03 0,01550419 ! quaternary ammonium group binding GO:0050997 7 6 0,000 2,882E-03 0,01548135 ! actin-dependent ATPase activity GO:0030898 7 6 0,000 2,882E-03 0,01545859 ! reproductive behavior GO:0019098 8 6 0,000 2,882E-03 0,01543589 ! response to growth hormone stimulus GO:0060416 7 6 0,000 2,882E-03 0,01541325 GO:0060396|growth hormone receptor signaling pathway, ! negative regulation of JAK-STAT cascade GO:0046426 8 6 0,000 2,882E-03 0,01539069 ! nucleotide-excision repair, DNA incision GO:0033683 6 6 0,000 2,882E-03 0,01536819 ! negative regulation of cell-cell adhesion GO:0022408 8 6 0,000 2,882E-03 0,01534575 ! positive regulation of cell-cell adhesion GO:0022409 7 6 0,000 2,882E-03 0,01532338 ! induction of positive chemotaxis GO:0050930 7 6 0,000 2,882E-03 0,01530108 ! cohesin complex GO:0008278 6 6 0,000 2,882E-03 0,01527884 ! regulation of collagen biosynthetic process GO:0032965 7 6 0,000 2,882E-03 0,01525666 ! citrate metabolic process GO:0006101 7 6 0,000 2,882E-03 0,01523455 ! myelin sheath GO:0043209 8 6 0,000 2,882E-03 0,0152125 ! phototransduction, visible light GO:0007603 6 6 0,000 2,882E-03 0,01519052 ! opsonization GO:0008228 7 6 0,000 2,882E-03 0,0151686 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016308 7 6 0,000 2,882E-03 0,01514674 ! regulation of dopamine metabolic process GO:0042053 8 6 0,000 2,882E-03 0,01512495 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 7 6 0,000 2,882E-03 0,01510322 ! regulation of potassium ion transport GO:0043266 8 6 0,000 2,882E-03 0,01508155 ! cell migration involved in gastrulation GO:0042074 7 6 0,000 2,882E-03 0,01505994 ! chemoattractant activity GO:0042056 6 6 0,000 2,882E-03 0,0150384 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine GO:0001993 8 6 0,000 2,882E-03 0,01501691 ! low-density lipoprotein particle remodeling GO:0034374 6 6 0,000 2,882E-03 0,01499549 ! ornithine decarboxylase regulator activity GO:0042979 6 6 0,000 2,882E-03 0,01497413 ! leukocyte degranulation GO:0043299 6 6 0,000 2,882E-03 0,01495283 ! bile acid and bile salt transport GO:0015721 7 6 0,000 2,882E-03 0,01493159 ! regulation of cytokine-mediated signaling pathway GO:0001959 11 6 0,000 2,882E-03 0,01491041 ! mitochondrial genome maintenance GO:0000002 6 6 0,000 2,882E-03 0,01488929 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 6 0,000 2,882E-03 0,01486823 ! DNA topoisomerase activity GO:0003916 6 6 0,000 2,882E-03 0,01484723 ! protein geranylgeranyltransferase activity GO:0004661 7 6 0,000 2,882E-03 0,01482629 ! ceramide biosynthetic process GO:0046513 6 6 0,000 2,882E-03 0,01480541 ! cyclin-dependent protein kinase activating kinase holoenzyme complex GO:0019907 7 6 0,000 2,882E-03 0,01478458 ! activin receptor activity GO:0017002 7 6 0,000 2,882E-03 0,01476382 ! astrocyte differentiation GO:0048708 6 6 0,000 2,882E-03 0,01474311 ! syncytium formation GO:0006949 6 6 0,000 2,882E-03 0,01472246 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 2,882E-03 0,01470187 ! neutrophil activation GO:0042119 6 6 0,000 2,882E-03 0,01468134 ! regulation of muscle hypertrophy GO:0014743 6 6 0,000 2,882E-03 0,01466086 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! regulation of appetite GO:0032098 6 6 0,000 2,882E-03 0,01464044 ! positive regulation of activated T cell proliferation GO:0042104 7 6 0,000 2,882E-03 0,01462008 ! positive transcription elongation factor activity GO:0008159 7 6 0,000 2,882E-03 0,01459978 ! NuA4 histone acetyltransferase complex GO:0035267 8 6 0,000 2,882E-03 0,01457953 ! cellular polysaccharide catabolic process GO:0044247 17 6 0,000 2,882E-03 0,01455933 GO:0009251|glucan catabolic process, ! response to salt stress GO:0009651 7 6 0,000 2,882E-03 0,0145392 ! neuron apoptosis GO:0051402 7 6 0,000 2,882E-03 0,01451912 ! folic acid transport GO:0015884 8 6 0,000 2,882E-03 0,01449909 ! carnitine transport GO:0015879 6 6 0,000 2,882E-03 0,01447912 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 6 6 0,000 2,882E-03 0,0144592 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, ! parturition GO:0007567 7 6 0,000 2,882E-03 0,01443934 ! S-methyltransferase activity GO:0008172 6 6 0,000 2,882E-03 0,01441953 ! phospholipase D activity GO:0004630 6 6 0,000 2,882E-03 0,01439978 ! poly-pyrimidine tract binding GO:0008187 6 6 0,000 2,882E-03 0,01438008 ! intercalated disc GO:0014704 8 6 0,000 2,882E-03 0,01436044 ! G2/M transition checkpoint GO:0031576 24 6 0,000 2,882E-03 0,01434084 GO:0031572|G2/M transition DNA damage checkpoint, ! interaction with symbiont GO:0051702 6 6 0,000 2,882E-03 0,01432131 ! IgG binding GO:0019864 6 6 0,000 2,882E-03 0,01430182 ! regulation of T cell cytokine production GO:0002724 6 6 0,000 2,882E-03 0,01428239 ! 3-hydroxyacyl-CoA dehydrogenase activity GO:0003857 6 6 0,000 2,882E-03 0,01426301 ! benzodiazepine receptor activity GO:0008503 7 6 0,000 2,882E-03 0,01424368 ! antigen processing and presentation of exogenous antigen GO:0019884 7 6 0,000 2,882E-03 0,01422441 ! regulation of T cell differentiation in the thymus GO:0033081 7 6 0,000 2,882E-03 0,01420519 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 6 6 0,000 2,882E-03 0,01418602 ! regulation of interleukin-4 production GO:0032673 6 6 0,000 2,882E-03 0,0141669 ! dendrite morphogenesis GO:0048813 7 6 0,000 2,882E-03 0,01414783 ! regulation of interleukin-1 production GO:0032652 7 6 0,000 2,882E-03 0,01412882 ! ribosomal large subunit biogenesis GO:0042273 7 6 0,000 2,882E-03 0,01410985 ! regulation of myeloid cell apoptosis GO:0033032 8 6 0,000 2,882E-03 0,01409094 ! nucleosome disassembly GO:0006337 7 6 0,000 2,882E-03 0,01407207 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! general transcriptional repressor activity GO:0016565 7 6 0,000 2,882E-03 0,01405326 ! regulation of mast cell activation GO:0033003 6 6 0,000 2,882E-03 0,0140345 ! tetracycline transporter activity GO:0008493 7 6 0,000 2,882E-03 0,01401579 GO:0042895|antibiotic transporter activity, ! guanylyltransferase activity GO:0070568 7 6 0,000 2,882E-03 0,01399712 ! receptor internalization GO:0031623 8 6 0,000 2,882E-03 0,01397851 ! N-formyl peptide receptor activity GO:0004982 6 6 0,000 2,882E-03 0,01395995 ! coenzyme A biosynthetic process GO:0015937 6 6 0,000 2,882E-03 0,01394143 ! histamine receptor activity GO:0004969 7 6 0,000 2,882E-03 0,01392297 ! N-methyl-D-aspartate selective glutamate receptor activity GO:0004972 9 6 0,000 2,882E-03 0,01390455 ! pyrimidine nucleotide sugar transmembrane transporter activity GO:0015165 6 6 0,000 2,882E-03 0,01388618 ! protein deubiquitination GO:0016579 6 6 0,000 2,882E-03 0,01386786 ! axonal fasciculation GO:0007413 7 6 0,000 2,882E-03 0,01384959 ! basic amino acid transmembrane transporter activity GO:0015174 6 6 0,000 2,882E-03 0,01383137 ! cytidine deaminase activity GO:0004126 6 6 0,000 2,882E-03 0,01381319 ! lipopolysaccharide-mediated signaling pathway GO:0031663 6 6 0,000 2,882E-03 0,01379506 ! energy coupled proton transport, against electrochemical gradient GO:0015988 7 6 0,000 2,882E-03 0,01377698 GO:0015991|ATP hydrolysis coupled proton transport, ! alpha-adrenergic receptor activity GO:0004936 9 6 0,000 2,882E-03 0,01375895 ! cytochrome-b5 reductase activity GO:0004128 7 6 0,000 2,882E-03 0,01374097 ! glycine binding GO:0016594 9 6 0,000 2,882E-03 0,01372303 ! apical protein localization GO:0045176 7 6 0,000 2,882E-03 0,01370514 ! ankyrin binding GO:0030506 6 6 0,000 2,882E-03 0,01368729 ! proton-transporting ATP synthase complex, catalytic core F(1) GO:0045261 6 6 0,000 2,882E-03 0,01366949 ! thyroid hormone receptor activity GO:0004887 7 6 0,000 2,882E-03 0,01365174 ! tyrosine phosphorylation of STAT protein GO:0007260 7 6 0,000 2,882E-03 0,01363403 ! progesterone metabolic process GO:0042448 6 6 0,000 2,882E-03 0,01361637 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 7 6 0,000 2,882E-03 0,01359876 ! GDP-dissociation inhibitor activity GO:0005092 6 6 0,000 2,882E-03 0,01358119 ! type II transforming growth factor beta receptor binding GO:0005114 6 6 0,000 2,882E-03 0,01356366 ! ATP catabolic process GO:0006200 6 6 0,000 2,882E-03 0,01354618 ! CoA carboxylase activity GO:0016421 6 6 0,000 2,882E-03 0,01352875 ! determination of adult lifespan GO:0008340 6 6 0,000 2,882E-03 0,01351136 ! S-acyltransferase activity GO:0016417 6 6 0,000 2,882E-03 0,01349402 ! somatic stem cell maintenance GO:0035019 6 6 0,000 2,882E-03 0,01347672 ! carnitine O-acyltransferase activity GO:0016406 6 6 0,000 2,882E-03 0,01345946 ! IkappaB kinase complex GO:0008385 7 6 0,000 2,882E-03 0,01344225 ! nucleobase transmembrane transporter activity GO:0015205 7 6 0,000 2,882E-03 0,01342508 ! store-operated calcium channel activity GO:0015279 6 6 0,000 2,882E-03 0,01340796 ! alkaline phosphatase activity GO:0004035 7 6 0,000 2,882E-03 0,01339088 ! aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 6 6 0,000 2,882E-03 0,01337384 ! unconventional myosin complex GO:0016461 8 6 0,000 2,882E-03 0,01335685 ! tRNA transcription GO:0009304 7 7 0,000 3,361E-03 0,01555989 ! respiratory burst GO:0045730 7 7 0,000 3,361E-03 0,01554017 ! telencephalon cell migration GO:0022029 8 7 0,000 3,361E-03 0,0155205 ! cytokinesis during cell cycle GO:0033205 7 7 0,000 3,361E-03 0,01550088 ! cation:chloride symporter activity GO:0015377 8 7 0,000 3,361E-03 0,0154813 ! RNA cap binding GO:0000339 8 7 0,000 3,361E-03 0,01546178 ! generation of neurons in the forebrain GO:0021872 8 7 0,000 3,361E-03 0,01544231 ! ephrin receptor binding GO:0046875 9 7 0,000 3,361E-03 0,01542288 ! male meiosis I GO:0007141 7 7 0,000 3,361E-03 0,01540351 ! synapsis GO:0007129 7 7 0,000 3,361E-03 0,01538418 GO:0070192|chromosome organization involved in meiosis, ! insulin receptor substrate binding GO:0043560 10 7 0,000 3,361E-03 0,0153649 ! N-terminal protein amino acid acetylation GO:0006474 8 7 0,000 3,361E-03 0,01534567 ! type I transforming growth factor beta receptor binding GO:0034713 8 7 0,000 3,361E-03 0,01532649 ! signal peptide processing GO:0006465 7 7 0,000 3,361E-03 0,01530736 ! regulation of cardiac muscle cell proliferation GO:0060043 8 7 0,000 3,361E-03 0,01528827 ! alpha(1,3)-fucosyltransferase activity GO:0046920 8 7 0,000 3,361E-03 0,01526923 ! macrophage chemotaxis GO:0048246 7 7 0,000 3,361E-03 0,01525024 ! Golgi cisterna membrane GO:0032580 7 7 0,000 3,361E-03 0,01523129 ! neurofilament cytoskeleton GO:0060053 8 7 0,000 3,361E-03 0,0152124 ! positive regulation of receptor-mediated endocytosis GO:0048260 7 7 0,000 3,361E-03 0,01519355 ! smoothened signaling pathway GO:0007224 8 7 0,000 3,361E-03 0,01517474 ! oxidoreductase activity, acting on CH or CH2 groups GO:0016725 7 7 0,000 3,361E-03 0,01515599 ! oxidoreductase activity, oxidizing metal ions GO:0016722 7 7 0,000 3,361E-03 0,01513727 ! cytoplasmic microtubule GO:0005881 7 7 0,000 3,361E-03 0,01511861 ! Arp2/3 protein complex GO:0005885 8 7 0,000 3,361E-03 0,01509999 ! fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331 7 7 0,000 3,361E-03 0,01508142 ! ATPase binding GO:0051117 8 7 0,000 3,361E-03 0,01506289 ! positive regulation of isotype switching GO:0045830 7 7 0,000 3,361E-03 0,01504441 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 3,361E-03 0,01502597 ! positive regulation of gene expression, epigenetic GO:0045815 7 7 0,000 3,361E-03 0,01500758 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 7 0,000 3,361E-03 0,01498923 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 3,361E-03 0,01497093 ! thymic T cell selection GO:0045061 16 7 0,000 3,361E-03 0,01495267 ! transepithelial chloride transport GO:0030321 7 7 0,000 3,361E-03 0,01493446 GO:0070633|transepithelial transport, ! adrenal gland development GO:0030325 7 7 0,000 3,361E-03 0,01491629 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 7 7 0,000 3,361E-03 0,01489817 ! negative regulation of survival gene product expression GO:0008634 9 7 0,000 3,361E-03 0,01488009 ! activation of caspase activity by cytochrome c GO:0008635 7 7 0,000 3,361E-03 0,01486205 ! melanocyte differentiation GO:0030318 8 7 0,000 3,361E-03 0,01484406 ! malate dehydrogenase activity GO:0016615 8 7 0,000 3,361E-03 0,01482611 ! mitochondrial respiratory chain complex assembly GO:0033108 7 7 0,000 3,361E-03 0,0148082 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! DNA secondary structure binding GO:0000217 16 7 0,000 3,361E-03 0,01479034 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor GO:0016653 8 7 0,000 3,361E-03 0,01477252 ! regulation of peptidyl-serine phosphorylation GO:0033135 7 7 0,000 3,361E-03 0,01475474 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 8 7 0,000 3,361E-03 0,01473701 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of granule cell precursor proliferation GO:0021936 7 7 0,000 3,361E-03 0,01471932 GO:0021940|positive regulation of granule cell precursor proliferation, ! V(D)J recombination GO:0033151 8 7 0,000 3,361E-03 0,01470167 ! tetrahydrobiopterin metabolic process GO:0046146 8 7 0,000 3,361E-03 0,01468406 ! vascular endothelial growth factor receptor activity GO:0005021 12 7 0,000 3,361E-03 0,0146665 ! central nervous system neuron axonogenesis GO:0021955 8 7 0,000 3,361E-03 0,01464898 GO:0021952|central nervous system projection neuron axonogenesis, ! oxidoreductase activity, acting on diphenols and related substances as donors GO:0016679 7 7 0,000 3,361E-03 0,01463149 GO:0016681|oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor, GO:0008121|ubiquinol-cytochrome-c reductase activity, ! response to tumor necrosis factor GO:0034612 8 7 0,000 3,361E-03 0,01461406 ! peptidoglycan metabolic process GO:0000270 9 7 0,000 3,361E-03 0,01459666 GO:0009253|peptidoglycan catabolic process, ! response to ATP GO:0033198 7 7 0,000 3,361E-03 0,0145793 ! signal recognition particle, endoplasmic reticulum targeting GO:0005786 8 7 0,000 3,361E-03 0,01456199 GO:0048500|signal recognition particle, ! stereocilium GO:0032420 10 7 0,000 3,361E-03 0,01454471 ! paraxial mesoderm morphogenesis GO:0048340 9 7 0,000 3,361E-03 0,01452748 ! melanosome organization GO:0032438 7 7 0,000 3,361E-03 0,01451029 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 8 7 0,000 3,361E-03 0,01449314 ! mesodermal cell differentiation GO:0048333 9 7 0,000 3,361E-03 0,01447602 GO:0001710|mesodermal cell fate commitment, ! positive regulation of neuroblast proliferation GO:0002052 7 7 0,000 3,361E-03 0,01445895 ! Rac protein signal transduction GO:0016601 7 7 0,000 3,361E-03 0,01444192 ! chondrocyte differentiation GO:0002062 7 7 0,000 3,361E-03 0,01442493 ! guanylate cyclase regulator activity GO:0030249 7 7 0,000 3,361E-03 0,01440798 GO:0010851|cyclase regulator activity, ! intestinal cholesterol absorption GO:0030299 9 7 0,000 3,361E-03 0,01439107 ! negative regulation of specific transcription from RNA polymerase II promoter GO:0010553 8 7 0,000 3,361E-03 0,0143742 ! positive regulation of mitotic cell cycle GO:0045931 7 7 0,000 3,361E-03 0,01435737 ! determination of anterior/posterior axis, embryo GO:0008595 10 7 0,000 3,361E-03 0,01434058 GO:0007350|blastoderm segmentation, GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 8 7 0,000 3,361E-03 0,01432382 ! regulation of vascular endothelial growth factor production GO:0010574 7 7 0,000 3,361E-03 0,01430711 ! Schwann cell differentiation GO:0014037 8 7 0,000 3,361E-03 0,01429043 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 9 7 0,000 3,361E-03 0,0142738 ! lipopolysaccharide biosynthetic process GO:0009103 7 7 0,000 3,361E-03 0,0142572 ! CDP-alcohol phosphatidyltransferase activity GO:0017169 7 7 0,000 3,361E-03 0,01424064 ! vinculin binding GO:0017166 9 7 0,000 3,361E-03 0,01422412 ! intrinsic to mitochondrial outer membrane GO:0031306 7 7 0,000 3,361E-03 0,01420764 ! regulation of collagen metabolic process GO:0010712 8 7 0,000 3,361E-03 0,01419119 ! wound healing, spreading of epidermal cells GO:0035313 7 7 0,000 3,361E-03 0,01417479 ! negative regulation of gliogenesis GO:0014014 8 7 0,000 3,361E-03 0,01415842 GO:0045686|negative regulation of glial cell differentiation, ! translation termination factor activity GO:0008079 7 7 0,000 3,361E-03 0,01414209 GO:0003747|translation release factor activity, ! purine base biosynthetic process GO:0009113 8 7 0,000 3,361E-03 0,0141258 ! cardiac muscle cell development GO:0055013 8 7 0,000 3,361E-03 0,01410954 ! fibrinolysis GO:0042730 9 7 0,000 3,361E-03 0,01409332 ! response to tropane GO:0014073 10 7 0,000 3,361E-03 0,01407714 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 7 7 0,000 3,361E-03 0,014061 GO:0051904|pigment granule transport, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 8 7 0,000 3,361E-03 0,01404489 ! glycosylceramide metabolic process GO:0006677 7 7 0,000 3,361E-03 0,01402882 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 7 7 0,000 3,361E-03 0,01401279 ! laminin-1 complex GO:0005606 7 7 0,000 3,361E-03 0,01399679 GO:0043256|laminin complex, ! regulation of chondrocyte differentiation GO:0032330 8 7 0,000 3,361E-03 0,01398084 ! positive regulation of immunoglobulin mediated immune response GO:0002891 7 7 0,000 3,361E-03 0,01396491 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of lipid transport GO:0032370 8 7 0,000 3,361E-03 0,01394902 ! regulation of cell division GO:0051302 7 7 0,000 3,361E-03 0,01393317 ! mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 10 7 0,000 3,361E-03 0,01391736 ! chitinase activity GO:0004568 7 7 0,000 3,361E-03 0,01390158 GO:0006046|N-acetylglucosamine catabolic process, GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! regulation of immune response to tumor cell GO:0002837 8 7 0,000 3,361E-03 0,01388584 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! U12-type spliceosomal complex GO:0005689 8 7 0,000 3,361E-03 0,01387013 ! regulation of respiratory burst GO:0060263 8 7 0,000 3,361E-03 0,01385445 ! prophase GO:0051324 8 7 0,000 3,361E-03 0,01383882 ! peptidyl-histidine modification GO:0018202 8 7 0,000 3,361E-03 0,01382322 ! centriolar satellite GO:0034451 10 7 0,000 3,361E-03 0,01380765 ! BBSome GO:0034464 7 7 0,000 3,361E-03 0,01379212 ! glycerophosphodiester phosphodiesterase activity GO:0008889 7 7 0,000 3,361E-03 0,01377662 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 3,361E-03 0,01376116 ! negative regulation of lymphocyte differentiation GO:0045620 8 7 0,000 3,361E-03 0,01374573 ! negative regulation of transmission of nerve impulse GO:0051970 7 7 0,000 3,361E-03 0,01373034 ! regulation of synaptic transmission, glutamatergic GO:0051966 8 7 0,000 3,361E-03 0,01371498 ! regulation of synaptogenesis GO:0051963 7 7 0,000 3,361E-03 0,01369966 ! serine family amino acid catabolic process GO:0009071 7 7 0,000 3,361E-03 0,01368437 ! MHC class I peptide loading complex GO:0042824 7 7 0,000 3,361E-03 0,01366911 ! glycolipid catabolic process GO:0019377 7 7 0,000 3,361E-03 0,01365389 GO:0046479|glycosphingolipid catabolic process, ! racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016857 8 7 0,000 3,361E-03 0,0136387 ! circadian behavior GO:0048512 9 7 0,000 3,361E-03 0,01362355 ! dorsal/ventral axis specification GO:0009950 7 7 0,000 3,361E-03 0,01360843 ! ligase activity, forming carbon-carbon bonds GO:0016885 9 7 0,000 3,361E-03 0,01359334 ! striatum development GO:0021756 7 7 0,000 3,361E-03 0,01357829 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0016812 8 7 0,000 3,361E-03 0,01356327 ! triglyceride biosynthetic process GO:0019432 7 7 0,000 3,361E-03 0,01354828 ! cerebellar Purkinje cell layer development GO:0021680 7 7 0,000 3,361E-03 0,01353332 ! carbon-nitrogen lyase activity GO:0016840 7 7 0,000 3,361E-03 0,0135184 ! dystroglycan complex GO:0016011 9 7 0,000 3,361E-03 0,01350352 ! negative regulation of calcium ion transport GO:0051926 7 7 0,000 3,361E-03 0,01348866 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 8 7 0,000 3,361E-03 0,01347384 ! peroxiredoxin activity GO:0051920 7 7 0,000 3,361E-03 0,01345905 ! muscle adaptation GO:0043500 7 7 0,000 3,361E-03 0,01344429 ! regulation of muscle adaptation GO:0043502 7 7 0,000 3,361E-03 0,01342956 ! diacylglycerol metabolic process GO:0046339 7 7 0,000 3,361E-03 0,01341487 ! lysogeny GO:0030069 7 7 0,000 3,361E-03 0,01340021 GO:0019047|provirus integration, ! protein insertion into membrane GO:0051205 7 7 0,000 3,361E-03 0,01338558 ! sequestering of metal ion GO:0051238 9 7 0,000 3,361E-03 0,01337098 ! membrane attack complex GO:0005579 7 7 0,000 3,361E-03 0,01335642 ! fibrinogen complex GO:0005577 7 7 0,000 3,361E-03 0,01334189 ! metallo-sulfur cluster assembly GO:0031163 9 7 0,000 3,361E-03 0,01332738 GO:0016226|iron-sulfur cluster assembly, ! extracellular matrix structural constituent conferring compression resistance GO:0030021 8 7 0,000 3,361E-03 0,01331291 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 8 7 0,000 3,361E-03 0,01329847 ! GABA receptor binding GO:0050811 8 7 0,000 3,361E-03 0,01328407 ! sheet-forming collagen GO:0030935 7 7 0,000 3,361E-03 0,01326969 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 8 7 0,000 3,361E-03 0,01325534 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 8 7 0,000 3,361E-03 0,01324103 ! sphingomyelin phosphodiesterase activity GO:0004767 9 7 0,000 3,361E-03 0,01322674 ! regulation of epithelial cell differentiation GO:0030856 7 7 0,000 3,361E-03 0,01321249 ! 7S RNA binding GO:0008312 8 7 0,000 3,361E-03 0,01319827 ! positive regulation of lipid catabolic process GO:0050996 7 7 0,000 3,361E-03 0,01318408 ! protein phosphorylated amino acid binding GO:0045309 9 7 0,000 3,361E-03 0,01316992 ! 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 8 7 0,000 3,361E-03 0,01315579 ! regulation of long-term neuronal synaptic plasticity GO:0048169 17 7 0,000 3,361E-03 0,01314169 ! Golgi to endosome transport GO:0006895 8 7 0,000 3,361E-03 0,01312761 ! glucocorticoid receptor signaling pathway GO:0042921 7 7 0,000 3,361E-03 0,01311357 GO:0031958|corticosteroid receptor signaling pathway, ! succinate metabolic process GO:0006105 7 7 0,000 3,361E-03 0,01309956 ! fibril GO:0043205 7 7 0,000 3,361E-03 0,01308558 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 3,361E-03 0,01307163 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 3,361E-03 0,01305771 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 7 0,000 3,361E-03 0,01304382 ! sensory perception of bitter taste GO:0050913 7 7 0,000 3,361E-03 0,01302996 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 3,361E-03 0,01301613 ! posttranscriptional gene silencing by RNA GO:0035194 9 7 0,000 3,361E-03 0,01300232 GO:0016441|posttranscriptional gene silencing, ! cell division site part GO:0032155 9 7 0,000 3,361E-03 0,01298855 GO:0032153|cell division site, ! laminin binding GO:0043236 7 7 0,000 3,361E-03 0,01297481 ! equilibrioception GO:0050957 10 7 0,000 3,361E-03 0,01296109 ! G-protein coupled receptor kinase activity GO:0004703 9 7 0,000 3,361E-03 0,0129474 ! titin binding GO:0031432 7 7 0,000 3,361E-03 0,01293375 ! chemosensory behavior GO:0007635 9 7 0,000 3,361E-03 0,01292012 ! regulation of response to extracellular stimulus GO:0032104 7 7 0,000 3,361E-03 0,01290652 GO:0032107|regulation of response to nutrient levels, ! plasma lipoprotein particle assembly GO:0034377 7 7 0,000 3,361E-03 0,01289295 ! cobalamin binding GO:0031419 7 7 0,000 3,361E-03 0,0128794 ! sodium:phosphate symporter activity GO:0005436 8 7 0,000 3,361E-03 0,01286589 ! response to axon injury GO:0048678 9 7 0,000 3,361E-03 0,0128524 ! regulation of activin receptor signaling pathway GO:0032925 7 7 0,000 3,361E-03 0,01283894 ! non-membrane spanning protein tyrosine phosphatase activity GO:0004726 8 7 0,000 3,361E-03 0,01282552 ! F-actin capping protein complex GO:0008290 8 7 0,000 3,361E-03 0,01281211 ! sphingoid biosynthetic process GO:0046520 7 7 0,000 3,361E-03 0,01279874 ! cGMP-mediated signaling GO:0019934 8 7 0,000 3,361E-03 0,01278539 ! nerve growth factor receptor signaling pathway GO:0048011 8 7 0,000 3,361E-03 0,01277208 ! cAMP-dependent protein kinase activity GO:0004691 7 7 0,000 3,361E-03 0,01275879 ! senescence GO:0010149 8 7 0,000 3,361E-03 0,01274552 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 10 7 0,000 3,361E-03 0,01273229 ! nuclear localization sequence binding GO:0008139 8 7 0,000 3,361E-03 0,01271908 ! galactose metabolic process GO:0006012 8 7 0,000 3,361E-03 0,0127059 ! vesicle fusion GO:0006906 8 7 0,000 3,361E-03 0,01269275 ! maintenance of protein location in nucleus GO:0051457 7 7 0,000 3,361E-03 0,01267962 ! intracellular pH reduction GO:0051452 7 7 0,000 3,361E-03 0,01266652 ! glycerol ether catabolic process GO:0044269 16 7 0,000 3,361E-03 0,01265345 GO:0046461|neutral lipid catabolic process, GO:0046464|acylglycerol catabolic process, ! neurotransmitter catabolic process GO:0042135 9 7 0,000 3,361E-03 0,0126404 ! ruffle organization GO:0031529 9 7 0,000 3,361E-03 0,01262739 ! nucleoside transport GO:0015858 8 7 0,000 3,361E-03 0,0126144 ! attachment of GPI anchor to protein GO:0016255 8 7 0,000 3,361E-03 0,01260143 ! inclusion body GO:0016234 7 7 0,000 3,361E-03 0,01258849 ! Cajal body GO:0015030 7 7 0,000 3,361E-03 0,01257558 ! H4/H2A histone acetyltransferase complex GO:0043189 9 7 0,000 3,361E-03 0,0125627 ! rRNA modification GO:0000154 7 7 0,000 3,361E-03 0,01254984 ! PcG protein complex GO:0031519 7 7 0,000 3,361E-03 0,01253701 ! phosphatidate phosphatase activity GO:0008195 7 7 0,000 3,361E-03 0,0125242 ! NAD-dependent protein deacetylase activity GO:0034979 7 7 0,000 3,361E-03 0,01251142 GO:0017136|NAD-dependent histone deacetylase activity, ! spindle checkpoint GO:0031577 7 7 0,000 3,361E-03 0,01249867 ! apolipoprotein binding GO:0034185 9 7 0,000 3,361E-03 0,01248594 ! G1 DNA damage checkpoint GO:0031571 7 7 0,000 3,361E-03 0,01247324 ! segment specification GO:0007379 9 7 0,000 3,361E-03 0,01246056 ! pronucleus GO:0045120 25 7 0,000 3,361E-03 0,01244791 ! bile acid:sodium symporter activity GO:0008508 9 7 0,000 3,361E-03 0,01243529 ! Rac GTPase activator activity GO:0030675 9 7 0,000 3,361E-03 0,01242269 ! regulation of DNA repair GO:0006282 19 7 0,000 3,361E-03 0,01241011 ! preribosome GO:0030684 7 7 0,000 3,361E-03 0,01239757 ! DNA topological change GO:0006265 7 7 0,000 3,361E-03 0,01238504 ! DNA ligation GO:0006266 8 7 0,000 3,361E-03 0,01237255 ! hair follicle maturation GO:0048820 8 7 0,000 3,361E-03 0,01236007 ! renal water homeostasis GO:0003091 7 7 0,000 3,361E-03 0,01234763 ! clathrin-coated endocytic vesicle membrane GO:0030669 7 7 0,000 3,361E-03 0,0123352 ! positive regulation of interleukin-6 production GO:0032755 7 7 0,000 3,361E-03 0,01232281 ! interleukin-1 receptor activity GO:0004908 8 7 0,000 3,361E-03 0,01231043 ! positive regulation of tumor necrosis factor production GO:0032760 7 7 0,000 3,361E-03 0,01229809 ! positive regulation of monooxygenase activity GO:0032770 7 7 0,000 3,361E-03 0,01228576 ! inositol trisphosphate 3-kinase activity GO:0008440 8 7 0,000 3,361E-03 0,01227347 ! phosphofructokinase activity GO:0008443 7 7 0,000 3,361E-03 0,01226119 ! gap junction channel activity GO:0005243 8 7 0,000 3,361E-03 0,01224894 ! 3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 10 7 0,000 3,361E-03 0,01223672 ! histone methylation GO:0016571 7 7 0,000 3,361E-03 0,01222452 ! positive regulation of interferon-gamma production GO:0032729 7 7 0,000 3,361E-03 0,01221234 ! negative regulation of tumor necrosis factor production GO:0032720 9 7 0,000 3,361E-03 0,01220019 ! mitochondrion morphogenesis GO:0070584 9 7 0,000 3,361E-03 0,01218806 ! muscle cell proliferation GO:0033002 8 7 0,000 3,361E-03 0,01217596 ! transcription termination GO:0006353 9 7 0,000 3,361E-03 0,01216388 ! regulation of transcription from RNA polymerase III promoter GO:0006359 16 7 0,000 3,361E-03 0,01215183 ! sodium:amino acid symporter activity GO:0005283 7 7 0,000 3,361E-03 0,01213979 ! cytidylyltransferase activity GO:0070567 8 7 0,000 3,361E-03 0,01212779 ! monolayer-surrounded lipid storage body GO:0012511 7 7 0,000 3,361E-03 0,0121158 ! ATP-dependent peptidase activity GO:0004176 7 7 0,000 3,361E-03 0,01210384 ! salivary gland development GO:0007431 7 7 0,000 3,361E-03 0,01209191 ! glucosidase activity GO:0015926 8 7 0,000 3,361E-03 0,01207999 ! NuRD complex GO:0016581 8 7 0,000 3,361E-03 0,0120681 ! negative regulation of nuclear division GO:0051784 7 7 0,000 3,361E-03 0,01205624 GO:0045839|negative regulation of mitosis, ! ATP-gated cation channel activity GO:0004931 9 7 0,000 3,361E-03 0,01204439 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 7 7 0,000 3,361E-03 0,01203257 ! response to redox state GO:0051775 8 7 0,000 3,361E-03 0,01202078 ! positive regulation of leukocyte chemotaxis GO:0002690 7 7 0,000 3,361E-03 0,012009 GO:0002688|regulation of leukocyte chemotaxis, ! melanin biosynthetic process GO:0042438 8 7 0,000 3,361E-03 0,01199725 ! procollagen-proline dioxygenase activity GO:0019798 7 7 0,000 3,361E-03 0,01198553 ! actin monomer binding GO:0003785 7 7 0,000 3,361E-03 0,01197382 ! protein prenyltransferase activity GO:0008318 8 7 0,000 3,361E-03 0,01196214 ! endosome to lysosome transport GO:0008333 7 7 0,000 3,361E-03 0,01195048 ! regulation of Rac protein signal transduction GO:0035020 17 7 0,000 3,361E-03 0,01193884 ! germ cell migration GO:0008354 7 7 0,000 3,361E-03 0,01192723 ! fibroblast growth factor receptor binding GO:0005104 8 7 0,000 3,361E-03 0,01191564 ! negative regulation of organic acid transport GO:0032891 8 7 0,000 3,361E-03 0,01190407 ! CoA-ligase activity GO:0016405 8 7 0,000 3,361E-03 0,01189252 ! positive regulation of NF-kappaB import into nucleus GO:0042346 8 7 0,000 3,361E-03 0,011881 ! interferon-alpha/beta receptor binding GO:0005132 7 7 0,000 3,361E-03 0,0118695 ! embryonic heart tube development GO:0035050 8 7 0,000 3,361E-03 0,01185802 ! dihydropyridine-sensitive calcium channel activity GO:0015270 10 7 0,000 3,361E-03 0,01184656 ! kainate selective glutamate receptor activity GO:0015277 8 7 0,000 3,361E-03 0,01183513 ! negative regulation of nucleotide metabolic process GO:0045980 8 7 0,000 3,361E-03 0,01182371 ! amiloride-sensitive sodium channel activity GO:0015280 7 7 0,000 3,361E-03 0,01181232 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 3,361E-03 0,01180096 ! adenylate kinase activity GO:0004017 8 7 0,000 3,361E-03 0,01178961 ! negative regulation of immune effector process GO:0002698 13 7 0,000 3,361E-03 0,01177828 ! C-X-C chemokine receptor activity GO:0016494 7 7 0,000 3,361E-03 0,01176698 ! vacuolar proton-transporting V-type ATPase complex GO:0016471 7 7 0,000 3,361E-03 0,0117557 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 10 8 0,000 3,84E-03 0,01341935 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 9 8 0,000 3,84E-03 0,0134065 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 8 0,000 3,84E-03 0,01339369 ! chaperone mediated protein folding requiring cofactor GO:0051085 8 8 0,000 3,84E-03 0,0133809 ! negative regulation of lipid biosynthetic process GO:0051055 18 8 0,000 3,84E-03 0,01336813 ! regulation of cellular amine metabolic process GO:0033238 10 8 0,000 3,84E-03 0,01335538 ! proteasome regulatory particle GO:0005838 8 8 0,000 3,84E-03 0,01334266 ! SMAD protein complex assembly GO:0007183 10 8 0,000 3,84E-03 0,01332997 ! regulation of smooth muscle cell migration GO:0014910 11 8 0,000 3,84E-03 0,0133173 ! protein self-association GO:0043621 8 8 0,000 3,84E-03 0,01330465 ! glycine hydroxymethyltransferase activity GO:0004372 9 8 0,000 3,84E-03 0,01329203 ! sodium:potassium-exchanging ATPase complex GO:0005890 10 8 0,000 3,84E-03 0,01327943 ! neurotransmitter uptake GO:0001504 8 8 0,000 3,84E-03 0,01326685 ! regulation of activated T cell proliferation GO:0046006 9 8 0,000 3,84E-03 0,0132543 ! guanylate cyclase activity GO:0004383 9 8 0,000 3,84E-03 0,01324177 ! troponin complex GO:0005861 8 8 0,000 3,84E-03 0,01322927 ! eukaryotic translation initiation factor 3 complex GO:0005852 8 8 0,000 3,84E-03 0,01321679 ! tachykinin receptor signaling pathway GO:0007217 8 8 0,000 3,84E-03 0,01320433 ! keratinocyte proliferation GO:0043616 9 8 0,000 3,84E-03 0,0131919 ! negative regulation of muscle cell differentiation GO:0051148 10 8 0,000 3,84E-03 0,01317949 ! microtubule bundle formation GO:0001578 8 8 0,000 3,84E-03 0,0131671 ! middle ear morphogenesis GO:0042474 10 8 0,000 3,84E-03 0,01315474 ! ganglioside metabolic process GO:0001573 8 8 0,000 3,84E-03 0,0131424 ! regulation of mesenchymal cell proliferation GO:0010464 9 8 0,000 3,84E-03 0,01313008 GO:0002053|positive regulation of mesenchymal cell proliferation, ! ovulation from ovarian follicle GO:0001542 8 8 0,000 3,84E-03 0,01311779 ! ciliary or flagellar motility GO:0001539 8 8 0,000 3,84E-03 0,01310552 ! pathogenesis GO:0009405 8 8 0,000 3,84E-03 0,01309327 ! pH reduction GO:0045851 9 8 0,000 3,84E-03 0,01308104 ! small protein activating enzyme activity GO:0008641 10 8 0,000 3,84E-03 0,01306884 ! ribonucleoside triphosphate catabolic process GO:0009203 8 8 0,000 3,84E-03 0,01305666 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 8 8 0,000 3,84E-03 0,0130445 ! hemoglobin metabolic process GO:0020027 8 8 0,000 3,84E-03 0,01303237 ! regulation of S phase of mitotic cell cycle GO:0007090 8 8 0,000 3,84E-03 0,01302026 ! arginine catabolic process GO:0006527 9 8 0,000 3,84E-03 0,01300817 ! T-tubule GO:0030315 9 8 0,000 3,84E-03 0,0129961 ! regulation of defense response to virus by virus GO:0050690 17 8 0,000 3,84E-03 0,01298406 ! histidine catabolic process GO:0006548 8 8 0,000 3,84E-03 0,01297203 GO:0009077|histidine family amino acid catabolic process, ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GO:0016624 8 8 0,000 3,84E-03 0,01296003 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 8 0,000 3,84E-03 0,01294806 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor GO:0016634 10 8 0,000 3,84E-03 0,0129361 ! proline metabolic process GO:0006560 10 8 0,000 3,84E-03 0,01292417 ! L-serine metabolic process GO:0006563 9 8 0,000 3,84E-03 0,01291226 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor GO:0016668 8 8 0,000 3,84E-03 0,01290037 ! melanosome membrane GO:0033162 9 8 0,000 3,84E-03 0,0128885 GO:0045009|chitosome, ! phosphagen metabolic process GO:0006599 8 8 0,000 3,84E-03 0,01287665 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 8 8 0,000 3,84E-03 0,01286483 ! pericentriolar material GO:0000242 9 8 0,000 3,84E-03 0,01285303 ! reverse cholesterol transport GO:0043691 8 8 0,000 3,84E-03 0,01284124 ! tumor necrosis factor receptor activity GO:0005031 8 8 0,000 3,84E-03 0,01282948 ! melanin metabolic process GO:0006582 10 8 0,000 3,84E-03 0,01281775 ! proton-transporting V-type ATPase, V1 domain GO:0033180 8 8 0,000 3,84E-03 0,01280603 ! phasic smooth muscle contraction GO:0014821 9 8 0,000 3,84E-03 0,01279434 ! Golgi lumen GO:0005796 8 8 0,000 3,84E-03 0,01278266 ! positive regulation of endothelial cell migration GO:0010595 9 8 0,000 3,84E-03 0,01277101 ! regulation of Cdc42 protein signal transduction GO:0032489 9 8 0,000 3,84E-03 0,01275938 GO:0043088|regulation of Cdc42 GTPase activity, ! methyltransferase complex GO:0034708 8 8 0,000 3,84E-03 0,01274777 GO:0035097|histone methyltransferase complex, ! paraxial mesoderm development GO:0048339 10 8 0,000 3,84E-03 0,01273618 ! stereocilium bundle GO:0032421 11 8 0,000 3,84E-03 0,01272461 ! forebrain cell migration GO:0021885 9 8 0,000 3,84E-03 0,01271306 ! peptidyl-threonine phosphorylation GO:0018107 11 8 0,000 3,84E-03 0,01270154 ! osteoblast development GO:0002076 11 8 0,000 3,84E-03 0,01269003 ! retinoic acid metabolic process GO:0042573 8 8 0,000 3,84E-03 0,01267855 ! retinol metabolic process GO:0042572 8 8 0,000 3,84E-03 0,01266709 ! negative regulation of muscle contraction GO:0045932 10 8 0,000 3,84E-03 0,01265564 ! structural constituent of epidermis GO:0030280 9 8 0,000 3,84E-03 0,01264422 ! clathrin binding GO:0030276 10 8 0,000 3,84E-03 0,01263282 ! phosphatidylinositol bisphosphate phosphatase activity GO:0034593 9 8 0,000 3,84E-03 0,01262144 ! chondroitin sulfate biosynthetic process GO:0030206 9 8 0,000 3,84E-03 0,01261008 GO:0030204|chondroitin sulfate metabolic process, ! sodium:dicarboxylate symporter activity GO:0017153 9 8 0,000 3,84E-03 0,01259874 ! motor axon guidance GO:0008045 8 8 0,000 3,84E-03 0,01258742 ! protein targeting to vacuole GO:0006623 8 8 0,000 3,84E-03 0,01257612 ! negative regulation of axonogenesis GO:0050771 12 8 0,000 3,84E-03 0,01256484 ! peptidyl-asparagine modification GO:0018196 8 8 0,000 3,84E-03 0,01255358 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! melanosome localization GO:0032400 8 8 0,000 3,84E-03 0,01254234 GO:0032401|establishment of melanosome localization, GO:0051875|pigment granule localization, GO:0051905|establishment of pigment granule localization, ! mismatch repair complex binding GO:0032404 10 8 0,000 3,84E-03 0,01253112 ! nucleoside diphosphate metabolic process GO:0009132 9 8 0,000 3,84E-03 0,01251993 ! protein-lipid complex assembly GO:0065005 8 8 0,000 3,84E-03 0,01250875 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 9 8 0,000 3,84E-03 0,01249759 ! phosphoinositide 3-kinase cascade GO:0014065 8 8 0,000 3,84E-03 0,01248645 ! regulation of dopamine secretion GO:0014059 9 8 0,000 3,84E-03 0,01247533 ! regulation of protein kinase B signaling cascade GO:0051896 9 8 0,000 3,84E-03 0,01246423 ! cranial nerve morphogenesis GO:0021602 9 8 0,000 3,84E-03 0,01245315 ! subpallium development GO:0021544 8 8 0,000 3,84E-03 0,01244209 ! positive regulation of Rho GTPase activity GO:0032321 11 8 0,000 3,84E-03 0,01243105 ! icosanoid secretion GO:0032309 10 8 0,000 3,84E-03 0,01242003 GO:0050482|arachidonic acid secretion, ! negative regulation of oxidoreductase activity GO:0051354 8 8 0,000 3,84E-03 0,01240903 ! regulation of DNA replication initiation GO:0030174 8 8 0,000 3,84E-03 0,01239805 ! negative regulation of cytokine secretion GO:0050710 10 8 0,000 3,84E-03 0,01238709 ! dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0004579 8 8 0,000 3,84E-03 0,01237615 ! exodeoxyribonuclease activity GO:0004529 18 8 0,000 3,84E-03 0,01236522 GO:0016895|exodeoxyribonuclease activity, producing 5'-phosphomonoesters, ! ER to Golgi transport vesicle GO:0030134 9 8 0,000 3,84E-03 0,01235432 ! nucleotide diphosphatase activity GO:0004551 9 8 0,000 3,84E-03 0,01234343 ! regulation of myoblast differentiation GO:0045661 9 8 0,000 3,84E-03 0,01233257 ! ubiquinone metabolic process GO:0006743 9 8 0,000 3,84E-03 0,01232172 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! neuromuscular process controlling posture GO:0050884 8 8 0,000 3,84E-03 0,01231089 ! multicellular organismal water homeostasis GO:0050891 8 8 0,000 3,84E-03 0,01230009 ! branched chain family amino acid catabolic process GO:0009083 9 8 0,000 3,84E-03 0,0122893 ! Wnt receptor activity GO:0042813 11 8 0,000 3,84E-03 0,01227853 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses GO:0016861 8 8 0,000 3,84E-03 0,01226777 ! leukocyte mediated cytotoxicity GO:0001909 10 8 0,000 3,84E-03 0,01225704 ! detection of calcium ion GO:0005513 9 8 0,000 3,84E-03 0,01224633 ! negative regulation of glucose import GO:0046325 9 8 0,000 3,84E-03 0,01223563 ! blastocyst growth GO:0001832 8 8 0,000 3,84E-03 0,01222495 ! regulation of fibrinolysis GO:0051917 8 8 0,000 3,84E-03 0,0122143 ! negative regulation of telomere maintenance GO:0032205 9 8 0,000 3,84E-03 0,01220366 ! cerebellar cortex formation GO:0021697 9 8 0,000 3,84E-03 0,01219304 ! complement binding GO:0001848 11 8 0,000 3,84E-03 0,01218243 ! regulation of actin filament bundle formation GO:0032231 13 8 0,000 3,84E-03 0,01217185 GO:0051492|regulation of stress fiber formation, ! regulation of synaptic transmission, dopaminergic GO:0032225 10 8 0,000 3,84E-03 0,01216128 ! negative regulation of blood vessel endothelial cell migration GO:0043537 9 8 0,000 3,84E-03 0,01215074 ! amino sugar catabolic process GO:0046348 8 8 0,000 3,84E-03 0,01214021 GO:0006043|glucosamine catabolic process, ! FK506 binding GO:0005528 9 8 0,000 3,84E-03 0,01212969 GO:0005527|macrolide binding, ! dipeptidase activity GO:0016805 8 8 0,000 3,84E-03 0,0121192 ! positive regulation of amine transport GO:0051954 9 8 0,000 3,84E-03 0,01210873 ! release of sequestered calcium ion into cytosol GO:0051209 13 8 0,000 3,84E-03 0,01209827 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, ! B cell receptor signaling pathway GO:0050853 13 8 0,000 3,84E-03 0,01208783 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 3,84E-03 0,01207741 ! Golgi transport complex GO:0017119 8 8 0,000 3,84E-03 0,01206701 ! positive regulation of protein ubiquitination GO:0031398 17 8 0,000 3,84E-03 0,01205662 ! GDP binding GO:0019003 9 8 0,000 3,84E-03 0,01204626 ! positive regulation of glucose metabolic process GO:0010907 8 8 0,000 3,84E-03 0,01203591 ! prostate gland development GO:0030850 17 8 0,000 3,84E-03 0,01202558 ! DNA synthesis during DNA repair GO:0000731 19 8 0,000 3,84E-03 0,01201526 ! nitric-oxide synthase binding GO:0050998 9 8 0,000 3,84E-03 0,01200497 ! phosphate transport GO:0006817 9 8 0,000 3,84E-03 0,01199469 ! cellular copper ion homeostasis GO:0006878 8 8 0,000 3,84E-03 0,01198443 ! oligopeptide transport GO:0006857 8 8 0,000 3,84E-03 0,01197419 GO:0015198|oligopeptide transporter activity, ! pigment cell differentiation GO:0050931 9 8 0,000 3,84E-03 0,01196396 ! 5'-nucleotidase activity GO:0008253 8 8 0,000 3,84E-03 0,01195375 ! oligosaccharyltransferase complex GO:0008250 8 8 0,000 3,84E-03 0,01194356 ! lipoprotein transport GO:0042953 9 8 0,000 3,84E-03 0,01193339 ! estrogen metabolic process GO:0008210 8 8 0,000 3,84E-03 0,01192323 ! nucleocytoplasmic transporter activity GO:0005487 8 8 0,000 3,84E-03 0,01191309 ! glucocorticoid metabolic process GO:0008211 8 8 0,000 3,84E-03 0,01190297 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 8 8 0,000 3,84E-03 0,01189287 ! T-helper 1 type immune response GO:0042088 8 8 0,000 3,84E-03 0,01188278 ! amyloid precursor protein catabolic process GO:0042987 10 8 0,000 3,84E-03 0,01187271 ! response to amphetamine GO:0001975 11 8 0,000 3,84E-03 0,01186266 ! mechanosensory behavior GO:0007638 8 8 0,000 3,84E-03 0,01185262 ! detection of chemical stimulus involved in sensory perception GO:0050907 8 8 0,000 3,84E-03 0,0118426 ! DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 8 8 0,000 3,84E-03 0,0118326 ! C-X-C chemokine binding GO:0019958 8 8 0,000 3,84E-03 0,01182261 ! two-component signal transduction system (phosphorelay) GO:0000160 9 8 0,000 3,84E-03 0,01181265 ! glycerolipid catabolic process GO:0046503 17 8 0,000 3,84E-03 0,01180269 ! spinal cord dorsal/ventral patterning GO:0021513 10 8 0,000 3,84E-03 0,01179276 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 9 8 0,000 3,84E-03 0,01178284 ! inositol phosphate-mediated signaling GO:0048016 9 8 0,000 3,84E-03 0,01177294 ! insulin-like growth factor receptor signaling pathway GO:0048009 8 8 0,000 3,84E-03 0,01176305 ! pigment granule organization GO:0048753 9 8 0,000 3,84E-03 0,01175319 ! GTP-dependent protein binding GO:0030742 11 8 0,000 3,84E-03 0,01174333 ! myeloid leukocyte mediated immunity GO:0002444 8 8 0,000 3,84E-03 0,0117335 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 8 0,000 3,84E-03 0,01172368 ! regulation of pigmentation during development GO:0048070 11 8 0,000 3,84E-03 0,01171388 ! macrophage activation GO:0042116 8 8 0,000 3,84E-03 0,01170409 ! poly(A) RNA binding GO:0008143 8 8 0,000 3,84E-03 0,01169432 ! positive regulation of insulin secretion GO:0032024 10 8 0,000 3,84E-03 0,01168457 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 18 8 0,000 3,84E-03 0,01167483 ! asymmetric protein localization GO:0008105 9 8 0,000 3,84E-03 0,01166511 ! nucleotide-sugar transmembrane transporter activity GO:0005338 8 8 0,000 3,84E-03 0,01165541 ! neurotrophin binding GO:0043121 10 8 0,000 3,84E-03 0,01164572 ! nucleoside transmembrane transporter activity GO:0005337 9 8 0,000 3,84E-03 0,01163604 ! positive regulation of multicellular organismal metabolic process GO:0044253 9 8 0,000 3,84E-03 0,01162639 ! phagocytosis, engulfment GO:0006911 10 8 0,000 3,84E-03 0,01161675 ! UDP-glucosyltransferase activity GO:0035251 8 8 0,000 3,84E-03 0,01160712 ! neurotransmitter biosynthetic process GO:0042136 9 8 0,000 3,84E-03 0,01159751 ! UV protection GO:0009650 9 8 0,000 3,84E-03 0,01158792 ! peptidyl-proline dioxygenase activity GO:0031543 8 8 0,000 3,84E-03 0,01157835 ! eukaryotic translation initiation factor 4F complex GO:0016281 10 8 0,000 3,84E-03 0,01156878 ! glutathione peroxidase activity GO:0004602 17 8 0,000 3,84E-03 0,01155924 ! acyl-CoA thioesterase activity GO:0016291 10 8 0,000 3,84E-03 0,01154971 ! ATP-binding cassette (ABC) transporter complex GO:0043190 8 8 0,000 3,84E-03 0,0115402 ! ferric iron binding GO:0008199 9 8 0,000 3,84E-03 0,0115307 ! response to UV-B GO:0010224 10 8 0,000 3,84E-03 0,01152122 ! intermediate filament organization GO:0045109 8 8 0,000 3,84E-03 0,01151175 ! protein-glutamine gamma-glutamyltransferase activity GO:0003810 8 8 0,000 3,84E-03 0,0115023 ! cellular extravasation GO:0045123 9 8 0,000 3,84E-03 0,01149286 ! skeletal muscle contraction GO:0003009 8 8 0,000 3,84E-03 0,01148344 ! positive regulation of cytokine production during immune response GO:0002720 8 8 0,000 3,84E-03 0,01147404 ! regulation of fatty acid biosynthetic process GO:0042304 17 8 0,000 3,84E-03 0,01146465 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 3,84E-03 0,01145527 ! antigen processing and presentation of endogenous antigen GO:0019883 8 8 0,000 3,84E-03 0,01144591 ! positive regulation of systemic arterial blood pressure GO:0003084 10 8 0,000 3,84E-03 0,01143657 ! negative regulation of systemic arterial blood pressure GO:0003085 9 8 0,000 3,84E-03 0,01142724 ! respiratory chain complex IV assembly GO:0008535 8 8 0,000 3,84E-03 0,01141793 ! erythrocyte development GO:0048821 9 8 0,000 3,84E-03 0,01140863 ! regulation of interleukin-10 production GO:0032653 8 8 0,000 3,84E-03 0,01139935 ! ribosome assembly GO:0042255 8 8 0,000 3,84E-03 0,01139008 ! postreplication repair GO:0006301 19 8 0,000 3,84E-03 0,01138083 ! gamma-tubulin binding GO:0043015 8 8 0,000 3,84E-03 0,01137159 ! NADPH oxidase complex GO:0043020 8 8 0,000 3,84E-03 0,01136237 ! mRNA cleavage GO:0006379 9 8 0,000 3,84E-03 0,01135316 ! UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity GO:0008499 9 8 0,000 3,84E-03 0,01134397 ! opioid receptor activity GO:0004985 8 8 0,000 3,84E-03 0,01133479 ! zymogen activation GO:0031638 9 8 0,000 3,84E-03 0,01132562 ! coenzyme A metabolic process GO:0015936 8 8 0,000 3,84E-03 0,01131648 ! cellular metabolic compound salvage GO:0043094 11 8 0,000 3,84E-03 0,01130734 ! costamere GO:0043034 8 8 0,000 3,84E-03 0,01129822 ! inositol trisphosphate kinase activity GO:0051766 9 8 0,000 3,84E-03 0,01128912 ! positive regulation of acute inflammatory response GO:0002675 8 8 0,000 3,84E-03 0,01128003 ! sarcomere organization GO:0045214 9 8 0,000 3,84E-03 0,01127096 ! wide pore channel activity GO:0022829 9 8 0,000 3,84E-03 0,0112619 ! ligand-regulated transcription factor activity GO:0003706 10 8 0,000 3,84E-03 0,01125285 ! RNA polymerase III transcription factor activity GO:0003709 8 8 0,000 3,84E-03 0,01124382 ! hormone catabolic process GO:0042447 9 8 0,000 3,84E-03 0,0112348 ! mRNA 3'-UTR binding GO:0003730 9 8 0,000 3,84E-03 0,0112258 ! cGMP biosynthetic process GO:0006182 9 8 0,000 3,84E-03 0,01121681 ! lysozyme activity GO:0003796 10 8 0,000 3,84E-03 0,01120784 ! death receptor binding GO:0005123 8 8 0,000 3,84E-03 0,01119888 ! protein modification by small protein removal GO:0070646 9 8 0,000 3,84E-03 0,01118993 ! adult feeding behavior GO:0008343 9 8 0,000 3,84E-03 0,011181 ! microtubule basal body GO:0005932 8 8 0,000 3,84E-03 0,01117209 ! pyrimidine nucleotide catabolic process GO:0006244 8 8 0,000 3,84E-03 0,01116319 ! interleukin-1 receptor binding GO:0005149 9 8 0,000 3,84E-03 0,0111543 ! calcium-release channel activity GO:0015278 8 8 0,000 3,84E-03 0,01114542 ! positive regulation of smooth muscle contraction GO:0045987 9 8 0,000 3,84E-03 0,01113656 ! behavioral response to nicotine GO:0035095 9 8 0,000 3,84E-03 0,01112772 ! aldehyde dehydrogenase (NAD) activity GO:0004029 9 8 0,000 3,84E-03 0,01111889 ! adenosine deaminase activity GO:0004000 8 8 0,000 3,84E-03 0,01111007 ! NAD biosynthetic process GO:0009435 9 8 0,000 3,84E-03 0,01110127 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 10 9 0,000 4,32E-03 0,01247637 ! positive regulation of glycogen biosynthetic process GO:0045725 9 9 0,000 4,32E-03 0,0124665 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 10 9 0,000 4,32E-03 0,01245664 ! sodium:hydrogen antiporter activity GO:0015385 9 9 0,000 4,32E-03 0,01244681 GO:0005451|monovalent cation:hydrogen antiporter activity, ! cGMP metabolic process GO:0046068 10 9 0,000 4,32E-03 0,01243698 ! myotube differentiation GO:0014902 9 9 0,000 4,32E-03 0,01242717 ! folic acid and derivative biosynthetic process GO:0009396 9 9 0,000 4,32E-03 0,01241738 ! N-glycan processing GO:0006491 10 9 0,000 4,32E-03 0,0124076 ! regulation of epidermal growth factor receptor activity GO:0007176 11 9 0,000 4,32E-03 0,01239784 ! actin-myosin filament sliding GO:0033275 11 9 0,000 4,32E-03 0,01238809 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! axon part GO:0033267 12 9 0,000 4,32E-03 0,01237836 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 10 9 0,000 4,32E-03 0,01236865 ! RNA methylation GO:0001510 9 9 0,000 4,32E-03 0,01235895 ! prostaglandin biosynthetic process GO:0001516 9 9 0,000 4,32E-03 0,01234926 GO:0046457|prostanoid biosynthetic process, ! negative regulation of gene-specific transcription GO:0032582 10 9 0,000 4,32E-03 0,01233959 ! artery development GO:0060840 9 9 0,000 4,32E-03 0,01232993 GO:0048844|artery morphogenesis, ! axonemal dynein complex GO:0005858 9 9 0,000 4,32E-03 0,01232029 ! regulation of postsynaptic membrane potential GO:0060078 11 9 0,000 4,32E-03 0,01231067 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 9 9 0,000 4,32E-03 0,01230106 ! auditory receptor cell differentiation GO:0042491 10 9 0,000 4,32E-03 0,01229146 ! positive regulation of heart contraction GO:0045823 11 9 0,000 4,32E-03 0,01228188 ! lipopolysaccharide binding GO:0001530 9 9 0,000 4,32E-03 0,01227232 ! regulated secretory pathway GO:0045055 10 9 0,000 4,32E-03 0,01226277 ! estrogen receptor binding GO:0030331 9 9 0,000 4,32E-03 0,01225323 ! inner mitochondrial membrane organization GO:0007007 10 9 0,000 4,32E-03 0,01224371 ! telomere maintenance via telomerase GO:0007004 20 9 0,000 4,32E-03 0,0122342 GO:0006278|RNA-dependent DNA replication, ! L-phenylalanine metabolic process GO:0006558 9 9 0,000 4,32E-03 0,01222471 GO:0006559|L-phenylalanine catabolic process, ! indolalkylamine metabolic process GO:0006586 9 9 0,000 4,32E-03 0,01221524 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 9 9 0,000 4,32E-03 0,01220577 ! urea metabolic process GO:0019627 19 9 0,000 4,32E-03 0,01219633 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! smooth endoplasmic reticulum GO:0005790 11 9 0,000 4,32E-03 0,01218689 ! autophagic vacuole GO:0005776 11 9 0,000 4,32E-03 0,01217748 ! Rac GTPase binding GO:0048365 10 9 0,000 4,32E-03 0,01216807 ! response to dietary excess GO:0002021 9 9 0,000 4,32E-03 0,01215868 ! regulation of sodium ion transport GO:0002028 10 9 0,000 4,32E-03 0,01214931 ! positive regulation of calcium ion transport into cytosol GO:0010524 13 9 0,000 4,32E-03 0,01213995 ! lens development in camera-type eye GO:0002088 9 9 0,000 4,32E-03 0,0121306 ! male sex determination GO:0030238 9 9 0,000 4,32E-03 0,01212127 ! positive regulation of vasodilation GO:0045909 19 9 0,000 4,32E-03 0,01211196 ! positive regulation of muscle contraction GO:0045933 11 9 0,000 4,32E-03 0,01210265 ! regulation of smoothened signaling pathway GO:0008589 11 9 0,000 4,32E-03 0,01209337 ! male germ cell nucleus GO:0001673 11 9 0,000 4,32E-03 0,01208409 ! negative regulation of foam cell differentiation GO:0010745 12 9 0,000 4,32E-03 0,01207483 ! copper ion homeostasis GO:0055070 9 9 0,000 4,32E-03 0,01206559 ! protein heterooligomerization GO:0051291 10 9 0,000 4,32E-03 0,01205635 ! spectrin GO:0008091 9 9 0,000 4,32E-03 0,01204714 ! cardiac muscle cell differentiation GO:0055007 12 9 0,000 4,32E-03 0,01203793 ! purine nucleoside triphosphate catabolic process GO:0009146 9 9 0,000 4,32E-03 0,01202874 ! synaptic vesicle exocytosis GO:0016079 10 9 0,000 4,32E-03 0,01201957 ! regulation of B cell differentiation GO:0045577 10 9 0,000 4,32E-03 0,01201041 ! cell differentiation in hindbrain GO:0021533 10 9 0,000 4,32E-03 0,01200126 ! neural tube patterning GO:0021532 10 9 0,000 4,32E-03 0,01199213 ! fucose catabolic process GO:0019317 10 9 0,000 4,32E-03 0,01198301 GO:0042355|L-fucose catabolic process, ! retinal ganglion cell axon guidance GO:0031290 10 9 0,000 4,32E-03 0,0119739 ! regulation of hormone metabolic process GO:0032350 12 9 0,000 4,32E-03 0,01196481 ! sterol catabolic process GO:0016127 10 9 0,000 4,32E-03 0,01195573 GO:0006707|cholesterol catabolic process, ! oligosaccharyl transferase activity GO:0004576 9 9 0,000 4,32E-03 0,01194667 ! clathrin coat of coated pit GO:0030132 11 9 0,000 4,32E-03 0,01193762 ! SNARE complex GO:0031201 11 9 0,000 4,32E-03 0,01192858 ! negative regulation of osteoclast differentiation GO:0045671 10 9 0,000 4,32E-03 0,01191956 ! negative regulation of glucose transport GO:0010829 10 9 0,000 4,32E-03 0,01191055 ! methionine biosynthetic process GO:0009086 11 9 0,000 4,32E-03 0,01190155 ! peptidoglycan binding GO:0042834 9 9 0,000 4,32E-03 0,01189257 ! serine family amino acid biosynthetic process GO:0009070 10 9 0,000 4,32E-03 0,0118836 ! somatic diversification of immunoglobulins during immune response GO:0002208 9 9 0,000 4,32E-03 0,01187465 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! nicotinamide nucleotide biosynthetic process GO:0019359 10 9 0,000 4,32E-03 0,0118657 ! intramolecular oxidoreductase activity, transposing S-S bonds GO:0016864 9 9 0,000 4,32E-03 0,01185678 GO:0003756|protein disulfide isomerase activity, ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor GO:0016884 9 9 0,000 4,32E-03 0,01184786 ! beta-1,3-galactosyltransferase activity GO:0048531 10 9 0,000 4,32E-03 0,01183896 ! detection of bacterium GO:0016045 10 9 0,000 4,32E-03 0,01183007 ! lymphocyte activation during immune response GO:0002285 9 9 0,000 4,32E-03 0,0118212 ! embryonic gut development GO:0048566 10 9 0,000 4,32E-03 0,01181234 ! hydrolase activity, acting on ether bonds GO:0016801 10 9 0,000 4,32E-03 0,01180349 ! desmosome GO:0030057 10 9 0,000 4,32E-03 0,01179465 ! long-chain-fatty-acid-CoA ligase activity GO:0004467 9 9 0,000 4,32E-03 0,01178583 ! T cell receptor signaling pathway GO:0050852 14 9 0,000 4,32E-03 0,01177702 ! positive regulation of calcium-mediated signaling GO:0050850 11 9 0,000 4,32E-03 0,01176823 ! actin filament polymerization GO:0030041 10 9 0,000 4,32E-03 0,01175944 ! negative regulation of B cell activation GO:0050869 10 9 0,000 4,32E-03 0,01175068 ! establishment of cell polarity GO:0030010 10 9 0,000 4,32E-03 0,01174192 ! regulation of synapse organization GO:0050807 10 9 0,000 4,32E-03 0,01173318 ! septin complex GO:0031105 10 9 0,000 4,32E-03 0,01172445 GO:0032156|septin cytoskeleton, ! cholesterol transporter activity GO:0017127 9 9 0,000 4,32E-03 0,01171573 ! anchoring collagen GO:0030934 9 9 0,000 4,32E-03 0,01170702 ! defense response to Gram-negative bacterium GO:0050829 10 9 0,000 4,32E-03 0,01169833 ! regulation of developmental growth GO:0048638 11 9 0,000 4,32E-03 0,01168966 ! negative regulation of smooth muscle cell proliferation GO:0048662 10 9 0,000 4,32E-03 0,01168099 ! GMP binding GO:0019002 11 9 0,000 4,32E-03 0,01167234 GO:0030553|cGMP binding, ! photoreceptor activity GO:0009881 10 9 0,000 4,32E-03 0,0116637 ! virus-host interaction GO:0019048 13 9 0,000 4,32E-03 0,01165507 ! pentose-phosphate shunt GO:0006098 11 9 0,000 4,32E-03 0,01164646 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 9 9 0,000 4,32E-03 0,01163785 ! negative regulation of lipid catabolic process GO:0050995 11 9 0,000 4,32E-03 0,01162927 ! non-recombinational repair GO:0000726 10 9 0,000 4,32E-03 0,01162069 GO:0006303|double-strand break repair via nonhomologous end joining, ! cell volume homeostasis GO:0006884 10 9 0,000 4,32E-03 0,01161213 ! nuclear telomere cap complex GO:0000783 10 9 0,000 4,32E-03 0,01160358 GO:0000782|telomere cap complex, ! activin binding GO:0048185 10 9 0,000 4,32E-03 0,01159504 ! social behavior GO:0035176 10 9 0,000 4,32E-03 0,01158651 ! regulation of positive chemotaxis GO:0050926 11 9 0,000 4,32E-03 0,011578 GO:0050927|positive regulation of positive chemotaxis, ! perikaryon GO:0043204 11 9 0,000 4,32E-03 0,0115695 ! nitric oxide biosynthetic process GO:0006809 10 9 0,000 4,32E-03 0,01156101 ! mating GO:0007618 11 9 0,000 4,32E-03 0,01155253 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 9 0,000 4,32E-03 0,01154407 ! rhythmic behavior GO:0007622 11 9 0,000 4,32E-03 0,01153562 ! phospholipid efflux GO:0033700 10 9 0,000 4,32E-03 0,01152718 ! cytoplasmic sequestering of transcription factor GO:0042994 9 9 0,000 4,32E-03 0,01151875 ! poly-purine tract binding GO:0070717 9 9 0,000 4,32E-03 0,01151034 ! T cell proliferation GO:0042098 10 9 0,000 4,32E-03 0,01150194 ! retinol dehydrogenase activity GO:0004745 9 9 0,000 4,32E-03 0,01149355 ! negative regulation of cell-matrix adhesion GO:0001953 10 9 0,000 4,32E-03 0,01148517 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 9 9 0,000 4,32E-03 0,01147681 ! interleukin-1 binding GO:0019966 10 9 0,000 4,32E-03 0,01146845 ! glucosyltransferase activity GO:0046527 9 9 0,000 4,32E-03 0,01146011 ! platelet-derived growth factor receptor signaling pathway GO:0048008 14 9 0,000 4,32E-03 0,01145178 ! cyclic nucleotide-dependent protein kinase activity GO:0004690 11 9 0,000 4,32E-03 0,01144347 ! ovulation GO:0030728 9 9 0,000 4,32E-03 0,01143516 ! acid phosphatase activity GO:0003993 18 9 0,000 4,32E-03 0,01142687 ! embryonic cranial skeleton morphogenesis GO:0048701 10 9 0,000 4,32E-03 0,01141859 ! ER overload response GO:0006983 11 9 0,000 4,32E-03 0,01141032 ! B cell proliferation GO:0042100 10 9 0,000 4,32E-03 0,01140207 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 11 9 0,000 4,32E-03 0,01139382 ! calcium-transporting ATPase activity GO:0005388 11 9 0,000 4,32E-03 0,01138559 ! mannose metabolic process GO:0006013 13 9 0,000 4,32E-03 0,01137737 ! lipid digestion GO:0044241 11 9 0,000 4,32E-03 0,01136916 ! tumor necrosis factor binding GO:0043120 9 9 0,000 4,32E-03 0,01136096 ! tRNA methyltransferase activity GO:0008175 9 9 0,000 4,32E-03 0,01135278 ! regulation of bone resorption GO:0045124 10 9 0,000 4,32E-03 0,0113446 ! brain morphogenesis GO:0048854 9 9 0,000 4,32E-03 0,01133644 ! positive regulation of alpha-beta T cell differentiation GO:0046638 10 9 0,000 4,32E-03 0,01132829 ! 1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 10 9 0,000 4,32E-03 0,01132015 ! synaptic vesicle membrane GO:0030672 9 9 0,000 4,32E-03 0,01131203 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 9 0,000 4,32E-03 0,01130391 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9 9 0,000 4,32E-03 0,01129581 ! kinesin binding GO:0019894 9 9 0,000 4,32E-03 0,01128772 ! multicellular organismal aging GO:0010259 18 9 0,000 4,32E-03 0,01127964 ! Ran GTPase binding GO:0008536 11 9 0,000 4,32E-03 0,01127157 ! ribosomal small subunit biogenesis GO:0042274 9 9 0,000 4,32E-03 0,01126351 ! protein import into peroxisome matrix GO:0016558 9 9 0,000 4,32E-03 0,01125547 ! mRNA polyadenylation GO:0006378 10 9 0,000 4,32E-03 0,01124743 ! neuropeptide Y receptor activity GO:0004983 10 9 0,000 4,32E-03 0,01123941 ! mannosyl-oligosaccharide mannosidase activity GO:0015924 14 9 0,000 4,32E-03 0,0112314 ! prostaglandin receptor activity GO:0004955 11 9 0,000 4,32E-03 0,0112234 ! caspase inhibitor activity GO:0043027 9 9 0,000 4,32E-03 0,01121541 ! adrenoceptor activity GO:0004935 12 9 0,000 4,32E-03 0,01120744 ! regulation of isotype switching GO:0045191 9 9 0,000 4,32E-03 0,01119947 ! positive regulation of leukocyte migration GO:0002687 10 9 0,000 4,32E-03 0,01119152 ! transmembrane receptor protein tyrosine kinase signaling protein activity GO:0005066 10 9 0,000 4,32E-03 0,01118357 ! positive regulation of ATPase activity GO:0032781 11 9 0,000 4,32E-03 0,01117564 ! nonprotein amino acid metabolic process GO:0019794 19 9 0,000 4,32E-03 0,01116772 ! ionotropic glutamate receptor complex GO:0008328 14 9 0,000 4,32E-03 0,01115981 ! Notch binding GO:0005112 10 9 0,000 4,32E-03 0,01115191 ! ATPase regulator activity GO:0060590 10 9 0,000 4,32E-03 0,01114403 ! gamma-tubulin complex GO:0000930 19 9 0,000 4,32E-03 0,01113615 ! pyrimidine base metabolic process GO:0006206 10 9 0,000 4,32E-03 0,01112829 ! establishment or maintenance of apical/basal cell polarity GO:0035088 10 9 0,000 4,32E-03 0,01112043 ! tubulin-tyrosine ligase activity GO:0004835 10 9 0,000 4,32E-03 0,01111259 ! alcohol dehydrogenase (NAD) activity GO:0004022 10 9 0,000 4,32E-03 0,01110476 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 12 10 0,000 4,798E-03 0,0123273 ! oligosaccharide biosynthetic process GO:0009312 10 10 0,000 4,798E-03 0,01231862 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 11 10 0,000 4,798E-03 0,01230996 ! sleep GO:0030431 11 10 0,000 4,798E-03 0,01230131 ! positive regulation of lipid biosynthetic process GO:0046889 10 10 0,000 4,798E-03 0,01229267 ! lipid particle GO:0005811 10 10 0,000 4,798E-03 0,01228405 ! filopodium assembly GO:0046847 14 10 0,000 4,798E-03 0,01227543 ! UTP metabolic process GO:0046051 12 10 0,000 4,798E-03 0,01226683 GO:0004550|nucleoside diphosphate kinase activity, GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! Wnt receptor signaling pathway through beta-catenin GO:0060070 13 10 0,000 4,798E-03 0,01225824 ! guanylate kinase activity GO:0004385 14 10 0,000 4,798E-03 0,01224966 ! integral to mitochondrial membrane GO:0032592 10 10 0,000 4,798E-03 0,01224109 ! COPI coating of Golgi vesicle GO:0048205 11 10 0,000 4,798E-03 0,01223254 GO:0048200|Golgi transport vesicle coating, ! platelet alpha granule membrane GO:0031092 11 10 0,000 4,798E-03 0,012224 ! macromolecule transmembrane transporter activity GO:0022884 11 10 0,000 4,798E-03 0,01221547 GO:0015450|P-P-bond-hydrolysis-driven protein transmembrane transporter activity, ! estradiol 17-beta-dehydrogenase activity GO:0004303 11 10 0,000 4,798E-03 0,01220695 ! thyroid hormone receptor coactivator activity GO:0030375 11 10 0,000 4,798E-03 0,01219844 GO:0010861|thyroid hormone receptor activator activity, ! regulation of receptor activity GO:0010469 12 10 0,000 4,798E-03 0,01218995 ! lung alveolus development GO:0048286 11 10 0,000 4,798E-03 0,01218147 ! regulation of chemokine biosynthetic process GO:0045073 11 10 0,000 4,798E-03 0,01217299 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 4,798E-03 0,01216453 ! negative regulation of striated muscle development GO:0045843 11 10 0,000 4,798E-03 0,01215609 ! oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GO:0050664 10 10 0,000 4,798E-03 0,01214765 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 11 10 0,000 4,798E-03 0,01213923 ! regulation of mRNA processing GO:0050684 12 10 0,000 4,798E-03 0,01213081 ! positive regulation of survival gene product expression GO:0045885 12 10 0,000 4,798E-03 0,01212241 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 11 10 0,000 4,798E-03 0,01211402 ! transforming growth factor beta binding GO:0050431 11 10 0,000 4,798E-03 0,01210565 ! histidine metabolic process GO:0006547 10 10 0,000 4,798E-03 0,01209728 GO:0009075|histidine family amino acid metabolic process, ! glucan biosynthetic process GO:0009250 10 10 0,000 4,798E-03 0,01208893 GO:0005978|glycogen biosynthetic process, ! endosome organization GO:0007032 13 10 0,000 4,798E-03 0,01208058 ! death receptor activity GO:0005035 11 10 0,000 4,798E-03 0,01207225 ! mitochondrial inner membrane presequence translocase complex GO:0005744 11 10 0,000 4,798E-03 0,01206393 ! entry into host cell GO:0030260 11 10 0,000 4,798E-03 0,01205562 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! protein kinase A binding GO:0051018 10 10 0,000 4,798E-03 0,01204733 ! filamentous actin GO:0031941 11 10 0,000 4,798E-03 0,01203904 ! behavioral fear response GO:0001662 12 10 0,000 4,798E-03 0,01203077 GO:0002209|behavioral defense response, ! bone mineralization GO:0030282 12 10 0,000 4,798E-03 0,0120225 ! negative regulation of ossification GO:0030279 12 10 0,000 4,798E-03 0,01201425 ! phosphatidylcholine biosynthetic process GO:0006656 11 10 0,000 4,798E-03 0,01200601 ! macrophage differentiation GO:0030225 11 10 0,000 4,798E-03 0,01199778 ! positive regulation of phagocytosis GO:0050766 11 10 0,000 4,798E-03 0,01198957 ! recycling endosome membrane GO:0055038 11 10 0,000 4,798E-03 0,01198136 ! regulation of fat cell differentiation GO:0045598 11 10 0,000 4,798E-03 0,01197316 ! snRNA metabolic process GO:0016073 10 10 0,000 4,798E-03 0,01196498 GO:0016180|snRNA processing, ! glycosphingolipid biosynthetic process GO:0006688 11 10 0,000 4,798E-03 0,01195681 ! regulation of mitochondrial membrane potential GO:0051881 11 10 0,000 4,798E-03 0,01194865 ! purine ribonucleotide catabolic process GO:0009154 10 10 0,000 4,798E-03 0,01194049 ! positive regulation of Ras GTPase activity GO:0032320 14 10 0,000 4,798E-03 0,01193236 ! immunoglobulin production during immune response GO:0002381 10 10 0,000 4,798E-03 0,01192423 ! nitric oxide metabolic process GO:0046209 20 10 0,000 4,798E-03 0,01191611 ! induction of an organ GO:0001759 12 10 0,000 4,798E-03 0,011908 ! response to estradiol stimulus GO:0032355 11 10 0,000 4,798E-03 0,01189991 ! synaptic vesicle endocytosis GO:0048488 12 10 0,000 4,798E-03 0,01189182 ! negative regulation of MAPKKK cascade GO:0043409 12 10 0,000 4,798E-03 0,01188375 ! positive regulation of interleukin-1 beta secretion GO:0050718 11 10 0,000 4,798E-03 0,01187569 ! MHC class II receptor activity GO:0032395 14 10 0,000 4,798E-03 0,01186764 ! peptidyl-lysine modification GO:0018205 11 10 0,000 4,798E-03 0,0118596 ! ribonuclease P activity GO:0004526 10 10 0,000 4,798E-03 0,01185157 ! COPI vesicle coat GO:0030126 12 10 0,000 4,798E-03 0,01184355 GO:0030663|COPI coated vesicle membrane, ! telomere maintenance via telomere lengthening GO:0010833 21 10 0,000 4,798E-03 0,01183554 ! vitamin transporter activity GO:0051183 12 10 0,000 4,798E-03 0,01182754 ! snRNA binding GO:0017069 11 10 0,000 4,798E-03 0,01181956 ! negative regulation of osteoblast differentiation GO:0045668 12 10 0,000 4,798E-03 0,01181158 ! heparan sulfate sulfotransferase activity GO:0034483 10 10 0,000 4,798E-03 0,01180362 ! fatty-acid ligase activity GO:0015645 10 10 0,000 4,798E-03 0,01179566 ! intramolecular transferase activity, phosphotransferases GO:0016868 11 10 0,000 4,798E-03 0,01178772 ! quaternary ammonium group transport GO:0015697 10 10 0,000 4,798E-03 0,01177979 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups GO:0016862 10 10 0,000 4,798E-03 0,01177187 ! metalloenzyme inhibitor activity GO:0048551 11 10 0,000 4,798E-03 0,01176396 GO:0008191|metalloendopeptidase inhibitor activity, GO:0010576|metalloenzyme regulator activity, ! anterior/posterior axis specification GO:0009948 14 10 0,000 4,798E-03 0,01175605 ! regulation of RNA splicing GO:0043484 13 10 0,000 4,798E-03 0,01174816 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0016813 10 10 0,000 4,798E-03 0,01174029 ! trophectodermal cell differentiation GO:0001829 11 10 0,000 4,798E-03 0,01173242 ! positive regulation of neuron apoptosis GO:0043525 11 10 0,000 4,798E-03 0,01172456 ! extracellular matrix binding GO:0050840 11 10 0,000 4,798E-03 0,01171671 ! regulation of synapse structure and activity GO:0050803 11 10 0,000 4,798E-03 0,01170887 ! autophagic vacuole formation GO:0000045 11 10 0,000 4,798E-03 0,01170105 ! clathrin-coated endocytic vesicle GO:0045334 10 10 0,000 4,798E-03 0,01169323 ! negative regulation of cell projection organization GO:0031345 14 10 0,000 4,798E-03 0,01168542 ! negative regulation of cellular catabolic process GO:0031330 11 10 0,000 4,798E-03 0,01167763 ! rough endoplasmic reticulum membrane GO:0030867 10 10 0,000 4,798E-03 0,01166984 ! thyroid gland development GO:0030878 12 10 0,000 4,798E-03 0,01166207 ! DNA bending activity GO:0008301 11 10 0,000 4,798E-03 0,0116543 ! regulation of phosphatase activity GO:0010921 10 10 0,000 4,798E-03 0,01164655 ! neutral lipid biosynthetic process GO:0046460 10 10 0,000 4,798E-03 0,01163881 GO:0046463|acylglycerol biosynthetic process, ! embryonic hindlimb morphogenesis GO:0035116 11 10 0,000 4,798E-03 0,01163107 ! embryonic forelimb morphogenesis GO:0035115 12 10 0,000 4,798E-03 0,01162335 ! regulation of glucan biosynthetic process GO:0010962 10 10 0,000 4,798E-03 0,01161564 GO:0005979|regulation of glycogen biosynthetic process, GO:0032885|regulation of polysaccharide biosynthetic process, ! secondary active sulfate transmembrane transporter activity GO:0008271 11 10 0,000 4,798E-03 0,01160793 ! regulation of glycolysis GO:0006110 11 10 0,000 4,798E-03 0,01160024 ! nucleotidase activity GO:0008252 10 10 0,000 4,798E-03 0,01159256 ! phosphatidylinositol phosphate kinase activity GO:0016307 11 10 0,000 4,798E-03 0,01158489 ! dipeptidyl-peptidase activity GO:0008239 12 10 0,000 4,798E-03 0,01157723 ! androgen metabolic process GO:0008209 11 10 0,000 4,798E-03 0,01156957 ! lateral plasma membrane GO:0016328 13 10 0,000 4,798E-03 0,01156193 ! MAP kinase kinase activity GO:0004708 12 10 0,000 4,798E-03 0,0115543 ! cation:amino acid symporter activity GO:0005416 12 10 0,000 4,798E-03 0,01154668 ! startle response GO:0001964 13 10 0,000 4,798E-03 0,01153907 ! amyloid precursor protein metabolic process GO:0042982 12 10 0,000 4,798E-03 0,01153147 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 12 10 0,000 4,798E-03 0,01152387 ! positive regulation of endothelial cell proliferation GO:0001938 13 10 0,000 4,798E-03 0,01151629 ! 3'-5'-exoribonuclease activity GO:0000175 10 10 0,000 4,798E-03 0,01150872 ! spinal cord patterning GO:0021511 12 10 0,000 4,798E-03 0,01150116 ! peptide or protein amino-terminal blocking GO:0018409 11 10 0,000 4,798E-03 0,01149361 ! MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017 10 10 0,000 4,798E-03 0,01148607 GO:0033549|MAP kinase phosphatase activity, ! response to X-ray GO:0010165 11 10 0,000 4,798E-03 0,01147853 ! embryonic eye morphogenesis GO:0048048 14 10 0,000 4,798E-03 0,01147101 ! sodium:potassium-exchanging ATPase activity GO:0005391 12 10 0,000 4,798E-03 0,0114635 ! zinc ion transmembrane transporter activity GO:0005385 13 10 0,000 4,798E-03 0,011456 ! positive regulation of glycogen metabolic process GO:0070875 11 10 0,000 4,798E-03 0,01144851 ! glucose transmembrane transporter activity GO:0005355 10 10 0,000 4,798E-03 0,01144102 ! regulation of intracellular pH GO:0051453 10 10 0,000 4,798E-03 0,01143355 ! retrograde transport, endosome to Golgi GO:0042147 12 10 0,000 4,798E-03 0,01142609 ! regulation of multicellular organismal metabolic process GO:0044246 11 10 0,000 4,798E-03 0,01141863 ! adult heart development GO:0007512 14 10 0,000 4,798E-03 0,01141119 ! neuromuscular junction development GO:0007528 12 10 0,000 4,798E-03 0,01140376 ! carbohydrate phosphatase activity GO:0019203 11 10 0,000 4,798E-03 0,01139633 ! O-methyltransferase activity GO:0008171 10 10 0,000 4,798E-03 0,01138892 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 10 10 0,000 4,798E-03 0,01138151 ! signalosome GO:0008180 10 10 0,000 4,798E-03 0,01137412 ! lysophospholipase activity GO:0004622 19 10 0,000 4,798E-03 0,01136673 ! prefoldin complex GO:0016272 10 10 0,000 4,798E-03 0,01135935 ! alpha-beta T cell differentiation GO:0046632 12 10 0,000 4,798E-03 0,01135199 ! negative regulation of insulin receptor signaling pathway GO:0046627 12 10 0,000 4,798E-03 0,01134463 ! positive regulation of T cell mediated immunity GO:0002711 10 10 0,000 4,798E-03 0,01133728 ! nucleoside bisphosphate metabolic process GO:0033865 10 10 0,000 4,798E-03 0,01132995 ! endocytic vesicle membrane GO:0030666 10 10 0,000 4,798E-03 0,01132262 ! gland morphogenesis GO:0022612 11 10 0,000 4,798E-03 0,0113153 ! icosanoid receptor activity GO:0004953 13 10 0,000 4,798E-03 0,01130799 GO:0004954|prostanoid receptor activity, ! regulation of macrophage activation GO:0043030 11 10 0,000 4,798E-03 0,01130069 ! peptide transporter activity GO:0015197 10 10 0,000 4,798E-03 0,0112934 ! proton-transporting ATP synthase complex, coupling factor F(o) GO:0045263 10 10 0,000 4,798E-03 0,01128612 ! regulation of leukocyte migration GO:0002685 11 10 0,000 4,798E-03 0,01127884 ! muscle maintenance GO:0046716 10 10 0,000 4,798E-03 0,01127158 ! acid secretion GO:0046717 12 10 0,000 4,798E-03 0,01126433 ! retinoid-X receptor activity GO:0004886 11 10 0,000 4,798E-03 0,01125708 ! catecholamine biosynthetic process GO:0042423 11 10 0,000 4,798E-03 0,01124985 ! thyroid hormone metabolic process GO:0042403 11 10 0,000 4,798E-03 0,01124262 ! GTPase inhibitor activity GO:0005095 21 10 0,000 4,798E-03 0,01123541 ! somatic recombination of immunoglobulin gene segments GO:0016447 10 10 0,000 4,798E-03 0,0112282 ! pattern recognition receptor activity GO:0008329 10 10 0,000 4,798E-03 0,011221 ! quinone cofactor metabolic process GO:0042375 11 10 0,000 4,798E-03 0,01121382 ! regulation of organic acid transport GO:0032890 12 10 0,000 4,798E-03 0,01120664 ! platelet-derived growth factor receptor binding GO:0005161 14 10 0,000 4,798E-03 0,01119947 ! C-acyltransferase activity GO:0016408 12 10 0,000 4,798E-03 0,01119231 ! cAMP-dependent protein kinase complex GO:0005952 12 10 0,000 4,798E-03 0,01118515 ! water channel activity GO:0015250 15 10 0,000 4,798E-03 0,01117801 ! phospholipase inhibitor activity GO:0004859 10 10 0,000 4,798E-03 0,01117088 ! regulation of embryonic development GO:0045995 12 10 0,000 4,798E-03 0,01116375 ! acrosome reaction GO:0007340 12 10 0,000 4,798E-03 0,01115664 ! mitochondrion localization GO:0051646 10 10 0,000 4,798E-03 0,01114953 ! cilium part GO:0044441 10 10 0,000 4,798E-03 0,01114244 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 12 11 0,000 5,277E-03 0,01224627 ! 'de novo' posttranslational protein folding GO:0051084 11 11 0,000 5,277E-03 0,01223848 ! negative regulation of blood pressure GO:0045776 13 11 0,000 5,277E-03 0,0122307 ! centriole GO:0005814 11 11 0,000 5,277E-03 0,01222294 ! cadmium ion binding GO:0046870 15 11 0,000 5,277E-03 0,01221518 ! hemoglobin complex GO:0005833 13 11 0,000 5,277E-03 0,01220744 ! CTP metabolic process GO:0046036 13 11 0,000 5,277E-03 0,0121997 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0009148|pyrimidine nucleoside triphosphate biosynthetic process, ! regulation of neurotransmitter secretion GO:0046928 12 11 0,000 5,277E-03 0,01219198 ! response to pain GO:0048265 12 11 0,000 5,277E-03 0,01218426 ! regulation of viral genome replication GO:0045069 13 11 0,000 5,277E-03 0,01217655 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 11 11 0,000 5,277E-03 0,01216886 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 12 11 0,000 5,277E-03 0,01216117 ! nucleotide-sugar metabolic process GO:0009225 13 11 0,000 5,277E-03 0,01215349 ! regulation of catecholamine secretion GO:0050433 12 11 0,000 5,277E-03 0,01214582 ! low-density lipoprotein receptor activity GO:0005041 11 11 0,000 5,277E-03 0,01213816 ! peptide antigen binding GO:0042605 14 11 0,000 5,277E-03 0,01213052 ! polyamine metabolic process GO:0006595 11 11 0,000 5,277E-03 0,01212288 ! lysosphingolipid and lysophosphatidic acid receptor activity GO:0001619 13 11 0,000 5,277E-03 0,01211525 GO:0045125|bioactive lipid receptor activity, ! nucleobase biosynthetic process GO:0046112 13 11 0,000 5,277E-03 0,01210763 ! regulation of calcium ion transport into cytosol GO:0010522 15 11 0,000 5,277E-03 0,01210002 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 12 11 0,000 5,277E-03 0,01209242 GO:0002717|positive regulation of natural killer cell mediated immunity, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 12 11 0,000 5,277E-03 0,01208483 ! protein homotetramerization GO:0051289 13 11 0,000 5,277E-03 0,01207725 ! regulation of gliogenesis GO:0014013 13 11 0,000 5,277E-03 0,01206967 GO:0045685|regulation of glial cell differentiation, ! oligodendrocyte development GO:0014003 11 11 0,000 5,277E-03 0,01206211 ! cytoskeletal adaptor activity GO:0008093 17 11 0,000 5,277E-03 0,01205456 ! regulation of circadian rhythm GO:0042752 11 11 0,000 5,277E-03 0,01204701 ! low-density lipoprotein receptor binding GO:0050750 11 11 0,000 5,277E-03 0,01203948 ! response to dsRNA GO:0043331 21 11 0,000 5,277E-03 0,01203196 ! response to amine stimulus GO:0014075 15 11 0,000 5,277E-03 0,01202444 GO:0010243|response to organic nitrogen, ! embryonic axis specification GO:0000578 14 11 0,000 5,277E-03 0,01201693 ! sphingomyelin metabolic process GO:0006684 13 11 0,000 5,277E-03 0,01200944 ! cell wall macromolecule catabolic process GO:0016998 14 11 0,000 5,277E-03 0,01200195 ! spinal cord motor neuron differentiation GO:0021522 12 11 0,000 5,277E-03 0,01199447 ! retinal binding GO:0016918 11 11 0,000 5,277E-03 0,011987 ! leukocyte activation during immune response GO:0002366 11 11 0,000 5,277E-03 0,01197955 GO:0002263|cell activation during immune response, ! regulation of sterol transport GO:0032371 12 11 0,000 5,277E-03 0,0119721 GO:0032374|regulation of cholesterol transport, ! beta-tubulin binding GO:0048487 14 11 0,000 5,277E-03 0,01196465 ! autonomic nervous system development GO:0048483 12 11 0,000 5,277E-03 0,01195722 ! negative regulation of lipid transport GO:0032369 12 11 0,000 5,277E-03 0,0119498 ! photoreceptor outer segment GO:0001750 12 11 0,000 5,277E-03 0,01194239 ! positive regulation of interleukin-1 secretion GO:0050716 12 11 0,000 5,277E-03 0,01193498 ! peptidyl-threonine modification GO:0018210 15 11 0,000 5,277E-03 0,01192759 ! clathrin coat of trans-Golgi network vesicle GO:0030130 15 11 0,000 5,277E-03 0,0119202 ! regulation of interleukin-1 beta secretion GO:0050706 12 11 0,000 5,277E-03 0,01191283 ! regulation of epidermis development GO:0045682 14 11 0,000 5,277E-03 0,01190546 ! positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 11 11 0,000 5,277E-03 0,0118981 ! midbrain development GO:0030901 12 11 0,000 5,277E-03 0,01189075 ! musculoskeletal movement GO:0050881 12 11 0,000 5,277E-03 0,01188341 GO:0050879|multicellular organismal movement, ! histone deacetylase binding GO:0042826 11 11 0,000 5,277E-03 0,01187608 ! regulation of RNA stability GO:0043487 13 11 0,000 5,277E-03 0,01186876 GO:0043488|regulation of mRNA stability, ! intramolecular oxidoreductase activity, transposing C=C bonds GO:0016863 11 11 0,000 5,277E-03 0,01186145 ! cell killing GO:0001906 13 11 0,000 5,277E-03 0,01185414 ! regulation of cellular carbohydrate catabolic process GO:0043471 13 11 0,000 5,277E-03 0,01184685 GO:0043470|regulation of carbohydrate catabolic process, ! oocyte development GO:0048599 12 11 0,000 5,277E-03 0,01183956 ! carbon-sulfur lyase activity GO:0016846 11 11 0,000 5,277E-03 0,01183229 ! cerebellar cortex morphogenesis GO:0021696 13 11 0,000 5,277E-03 0,01182502 ! regulation of blood vessel endothelial cell migration GO:0043535 13 11 0,000 5,277E-03 0,01181776 ! folic acid binding GO:0005542 12 11 0,000 5,277E-03 0,01181051 ! mRNA 3'-end processing GO:0031124 12 11 0,000 5,277E-03 0,01180327 ! regulation of calcium-mediated signaling GO:0050848 13 11 0,000 5,277E-03 0,01179603 ! positive regulation of protein polymerization GO:0032273 11 11 0,000 5,277E-03 0,01178881 ! microspike assembly GO:0030035 15 11 0,000 5,277E-03 0,0117816 ! lamellipodium assembly GO:0030032 22 11 0,000 5,277E-03 0,01177439 ! fibrillar collagen GO:0005583 12 11 0,000 5,277E-03 0,01176719 ! inner ear receptor cell differentiation GO:0060113 12 11 0,000 5,277E-03 0,01176001 ! cytoplasmic sequestering of protein GO:0051220 12 11 0,000 5,277E-03 0,01175283 ! negative regulation of muscle development GO:0048635 13 11 0,000 5,277E-03 0,01174566 ! very-long-chain fatty acid metabolic process GO:0000038 12 11 0,000 5,277E-03 0,01173849 ! synaptonemal complex GO:0000795 11 11 0,000 5,277E-03 0,01173134 ! reproductive cellular process GO:0048610 13 11 0,000 5,277E-03 0,0117242 ! cortical actin cytoskeleton organization GO:0030866 12 11 0,000 5,277E-03 0,01171706 ! Golgi vesicle budding GO:0048194 12 11 0,000 5,277E-03 0,01170993 ! response to cAMP GO:0051591 11 11 0,000 5,277E-03 0,01170281 ! detection of mechanical stimulus GO:0050982 13 11 0,000 5,277E-03 0,0116957 ! 1-phosphatidylinositol-3-kinase activity GO:0016303 13 11 0,000 5,277E-03 0,0116886 ! regulation of cell projection assembly GO:0060491 11 11 0,000 5,277E-03 0,01168151 ! negative regulation of transcription factor import into nucleus GO:0042992 11 11 0,000 5,277E-03 0,01167443 ! positive regulation of transcription factor import into nucleus GO:0042993 13 11 0,000 5,277E-03 0,01166735 ! macromolecular complex remodeling GO:0034367 11 11 0,000 5,277E-03 0,01166028 GO:0034368|protein-lipid complex remodeling, GO:0034369|plasma lipoprotein particle remodeling, ! protein serine/threonine/tyrosine kinase activity GO:0004712 13 11 0,000 5,277E-03 0,01165323 ! glycerol ether biosynthetic process GO:0046504 11 11 0,000 5,277E-03 0,01164618 ! drug transport GO:0015893 12 11 0,000 5,277E-03 0,01163913 ! FMN binding GO:0010181 12 11 0,000 5,277E-03 0,0116321 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 11 0,000 5,277E-03 0,01162508 ! water transporter activity GO:0005372 17 11 0,000 5,277E-03 0,01161806 ! regulation of glycogen metabolic process GO:0070873 12 11 0,000 5,277E-03 0,01161105 GO:0032881|regulation of polysaccharide metabolic process, ! substrate-bound cell migration GO:0006929 13 11 0,000 5,277E-03 0,01160406 ! multicellular organism growth GO:0035264 12 11 0,000 5,277E-03 0,01159707 ! integrator complex GO:0032039 11 11 0,000 5,277E-03 0,01159008 ! L-glutamate transmembrane transporter activity GO:0005313 13 11 0,000 5,277E-03 0,01158311 GO:0015172|acidic amino acid transmembrane transporter activity, ! DNA integration GO:0015074 11 11 0,000 5,277E-03 0,01157614 ! brush border membrane GO:0031526 12 11 0,000 5,277E-03 0,01156919 ! actin cytoskeleton reorganization GO:0031532 14 11 0,000 5,277E-03 0,01156224 ! negative regulation of caspase activity GO:0043154 12 11 0,000 5,277E-03 0,0115553 ! macroautophagy GO:0016236 12 11 0,000 5,277E-03 0,01154837 ! protein disulfide oxidoreductase activity GO:0015035 11 11 0,000 5,277E-03 0,01154144 ! neuromuscular junction GO:0031594 12 11 0,000 5,277E-03 0,01153453 ! positive regulation of peptide secretion GO:0002793 13 11 0,000 5,277E-03 0,01152762 ! positive regulation of alpha-beta T cell activation GO:0046635 12 11 0,000 5,277E-03 0,01152072 ! organic anion transmembrane transporter activity GO:0008514 11 11 0,000 5,277E-03 0,01151383 ! response to antibiotic GO:0046677 13 11 0,000 5,277E-03 0,01150695 ! protein-hormone receptor activity GO:0016500 12 11 0,000 5,277E-03 0,01150008 ! bile acid transmembrane transporter activity GO:0015125 13 11 0,000 5,277E-03 0,01149321 ! proteasome accessory complex GO:0022624 11 11 0,000 5,277E-03 0,01148635 ! neuroblast proliferation GO:0007405 13 11 0,000 5,277E-03 0,0114795 ! non-G-protein coupled 7TM receptor activity GO:0004926 14 11 0,000 5,277E-03 0,01147266 ! negative regulation of neurological system process GO:0031645 13 11 0,000 5,277E-03 0,01146583 ! nitric oxide mediated signal transduction GO:0007263 12 11 0,000 5,277E-03 0,01145901 ! protein kinase C binding GO:0005080 11 11 0,000 5,277E-03 0,01145219 ! transforming growth factor beta receptor, cytoplasmic mediator activity GO:0005072 12 11 0,000 5,277E-03 0,01144538 ! male genitalia development GO:0030539 15 11 0,000 5,277E-03 0,01143858 ! receptor inhibitor activity GO:0030547 12 11 0,000 5,277E-03 0,01143179 GO:0048019|receptor antagonist activity, ! estrogen receptor signaling pathway GO:0030520 12 11 0,000 5,277E-03 0,011425 ! L-fucose metabolic process GO:0042354 13 11 0,000 5,277E-03 0,01141823 ! palmitoyltransferase activity GO:0016409 11 11 0,000 5,277E-03 0,01141146 ! arylsulfatase activity GO:0004065 12 11 0,000 5,277E-03 0,0114047 ! sterol transporter activity GO:0015248 11 11 0,000 5,277E-03 0,01139794 ! response to nicotine GO:0035094 13 11 0,000 5,277E-03 0,0113912 ! adenylate cyclase activity GO:0004016 11 11 0,000 5,277E-03 0,01138446 ! rRNA transcription GO:0009303 12 12 0,000 5,756E-03 0,01240942 ! ER-associated protein catabolic process GO:0030433 14 12 0,000 5,756E-03 0,01240209 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of blood pressure GO:0045777 15 12 0,000 5,756E-03 0,01239477 ! superoxide anion generation GO:0042554 12 12 0,000 5,756E-03 0,01238746 ! pteridine and derivative biosynthetic process GO:0042559 22 12 0,000 5,756E-03 0,01238016 ! regulation of S phase GO:0033261 16 12 0,000 5,756E-03 0,01237286 ! regulation of chemokine production GO:0032642 13 12 0,000 5,756E-03 0,01236557 ! male meiosis GO:0007140 12 12 0,000 5,756E-03 0,0123583 ! signal complex assembly GO:0007172 15 12 0,000 5,756E-03 0,01235103 ! positive regulation of GTPase activity GO:0043547 17 12 0,000 5,756E-03 0,01234377 ! GTP metabolic process GO:0046039 14 12 0,000 5,756E-03 0,01233651 ! retina morphogenesis in camera-type eye GO:0060042 16 12 0,000 5,756E-03 0,01232927 ! hair follicle morphogenesis GO:0031069 14 12 0,000 5,756E-03 0,01232203 ! voltage-gated sodium channel complex GO:0001518 15 12 0,000 5,756E-03 0,01231481 GO:0034706|sodium channel complex, ! RNA polyadenylation GO:0043631 13 12 0,000 5,756E-03 0,01230759 ! cartilage condensation GO:0001502 14 12 0,000 5,756E-03 0,01230038 ! polysome GO:0005844 14 12 0,000 5,756E-03 0,01229318 ! hippocampus development GO:0021766 13 12 0,000 5,756E-03 0,01228598 ! lipoprotein receptor binding GO:0070325 13 12 0,000 5,756E-03 0,0122788 ! beta-amyloid binding GO:0001540 12 12 0,000 5,756E-03 0,01227162 ! negative regulation of endocytosis GO:0045806 15 12 0,000 5,756E-03 0,01226445 ! regulation of interferon-gamma biosynthetic process GO:0045072 15 12 0,000 5,756E-03 0,01225729 ! regulation of exit from mitosis GO:0007096 31 12 0,000 5,756E-03 0,01225014 ! chylomicron GO:0042627 13 12 0,000 5,756E-03 0,012243 ! T cell selection GO:0045058 22 12 0,000 5,756E-03 0,01223587 ! negative regulation of proteolysis GO:0045861 12 12 0,000 5,756E-03 0,01222874 ! glycolipid biosynthetic process GO:0009247 13 12 0,000 5,756E-03 0,01222162 ! WW domain binding GO:0050699 12 12 0,000 5,756E-03 0,01221451 ! methionine metabolic process GO:0006555 14 12 0,000 5,756E-03 0,01220741 ! nuclear heterochromatin GO:0005720 12 12 0,000 5,756E-03 0,01220032 ! glycine metabolic process GO:0006544 14 12 0,000 5,756E-03 0,01219323 ! plasma membrane organization GO:0007009 12 12 0,000 5,756E-03 0,01218616 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 5,756E-03 0,01217909 ! ribonucleotide catabolic process GO:0009261 12 12 0,000 5,756E-03 0,01217203 ! Golgi organization GO:0007030 15 12 0,000 5,756E-03 0,01216497 ! hydrogen ion transporting ATP synthase activity, rotational mechanism GO:0046933 12 12 0,000 5,756E-03 0,01215793 ! mitotic spindle organization GO:0007052 13 12 0,000 5,756E-03 0,01215089 ! integral to peroxisomal membrane GO:0005779 12 12 0,000 5,756E-03 0,01214387 ! integral to membrane of membrane fraction GO:0000299 13 12 0,000 5,756E-03 0,01213685 ! regulation of the force of heart contraction GO:0002026 13 12 0,000 5,756E-03 0,01212984 ! temperature homeostasis GO:0001659 13 12 0,000 5,756E-03 0,01212283 ! negative regulation of mitotic cell cycle GO:0045930 15 12 0,000 5,756E-03 0,01211584 ! acyl-CoA metabolic process GO:0006637 12 12 0,000 5,756E-03 0,01210885 ! lipoprotein receptor activity GO:0030228 12 12 0,000 5,756E-03 0,01210187 ! cotranslational protein targeting to membrane GO:0006613 14 12 0,000 5,756E-03 0,0120949 ! axon cargo transport GO:0008088 13 12 0,000 5,756E-03 0,01208794 ! regulation of phagocytosis GO:0050764 14 12 0,000 5,756E-03 0,01208098 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 14 12 0,000 5,756E-03 0,01207403 ! nucleoside triphosphate catabolic process GO:0009143 12 12 0,000 5,756E-03 0,0120671 ! transcription elongation factor complex GO:0008023 12 12 0,000 5,756E-03 0,01206016 ! basal lamina GO:0005605 12 12 0,000 5,756E-03 0,01205324 ! regulation of interleukin-1 secretion GO:0050704 13 12 0,000 5,756E-03 0,01204633 ! pancreatic ribonuclease activity GO:0004522 12 12 0,000 5,756E-03 0,01203942 ! tRNA-specific ribonuclease activity GO:0004549 12 12 0,000 5,756E-03 0,01203252 ! biomineral formation GO:0031214 14 12 0,000 5,756E-03 0,01202563 ! water homeostasis GO:0030104 12 12 0,000 5,756E-03 0,01201874 ! promoter binding GO:0010843 14 12 0,000 5,756E-03 0,01201187 ! regulation of erythrocyte differentiation GO:0045646 15 12 0,000 5,756E-03 0,012005 ! intestinal absorption GO:0050892 14 12 0,000 5,756E-03 0,01199814 ! pseudouridine synthase activity GO:0009982 12 12 0,000 5,756E-03 0,01199129 ! oocyte differentiation GO:0009994 13 12 0,000 5,756E-03 0,01198444 ! oxygen transport GO:0015671 13 12 0,000 5,756E-03 0,01197761 GO:0005344|oxygen transporter activity, ! cholesterol efflux GO:0033344 13 12 0,000 5,756E-03 0,01197078 ! digestive tract morphogenesis GO:0048546 14 12 0,000 5,756E-03 0,01196396 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! racemase and epimerase activity GO:0016854 13 12 0,000 5,756E-03 0,01195714 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 14 12 0,000 5,756E-03 0,01195034 ! tropomyosin binding GO:0005523 12 12 0,000 5,756E-03 0,01194354 ! blastocyst formation GO:0001825 13 12 0,000 5,756E-03 0,01193675 ! regulation of telomere maintenance GO:0032204 16 12 0,000 5,756E-03 0,01192997 ! internal side of plasma membrane GO:0009898 16 12 0,000 5,756E-03 0,01192319 ! mannose binding GO:0005537 13 12 0,000 5,756E-03 0,01191643 ! phosphoprotein binding GO:0051219 14 12 0,000 5,756E-03 0,01190967 ! defense response to fungus GO:0050832 12 12 0,000 5,756E-03 0,01190292 ! embryonic placenta development GO:0001892 16 12 0,000 5,756E-03 0,01189617 ! regulation of steroid biosynthetic process GO:0050810 12 12 0,000 5,756E-03 0,01188944 ! cell wall macromolecule metabolic process GO:0044036 15 12 0,000 5,756E-03 0,01188271 ! acyl-CoA binding GO:0000062 12 12 0,000 5,756E-03 0,01187599 ! cortical cytoskeleton organization GO:0030865 13 12 0,000 5,756E-03 0,01186927 ! regulation of nitric-oxide synthase activity GO:0050999 12 12 0,000 5,756E-03 0,01186257 ! copper ion transport GO:0006825 12 12 0,000 5,756E-03 0,01185587 ! calcium ion transport into cytosol GO:0060402 19 12 0,000 5,756E-03 0,01184918 ! inositol metabolic process GO:0006020 21 12 0,000 5,756E-03 0,0118425 ! vesicle targeting, to, from or within Golgi GO:0048199 13 12 0,000 5,756E-03 0,01183582 ! forelimb morphogenesis GO:0035136 15 12 0,000 5,756E-03 0,01182915 ! protein complex disassembly GO:0043241 15 12 0,000 5,756E-03 0,01182249 GO:0043624|cellular protein complex disassembly, ! ion channel inhibitor activity GO:0008200 15 12 0,000 5,756E-03 0,01181584 GO:0016248|channel inhibitor activity, ! low-density lipoprotein particle GO:0034362 13 12 0,000 5,756E-03 0,01180919 ! lipoprotein particle clearance GO:0034381 14 12 0,000 5,756E-03 0,01180256 ! receptor signaling protein tyrosine kinase activity GO:0004716 14 12 0,000 5,756E-03 0,01179592 ! endothelial cell differentiation GO:0045446 15 12 0,000 5,756E-03 0,0117893 ! exosome (RNase complex) GO:0000178 13 12 0,000 5,756E-03 0,01178269 ! DNA N-glycosylase activity GO:0019104 12 12 0,000 5,756E-03 0,01177608 ! endoderm development GO:0007492 13 12 0,000 5,756E-03 0,01176948 ! positive regulation of Ras protein signal transduction GO:0046579 25 12 0,000 5,756E-03 0,01176288 ! focal adhesion formation GO:0048041 16 12 0,000 5,756E-03 0,0117563 ! T cell receptor complex GO:0042101 31 12 0,000 5,756E-03 0,01174972 ! cellular carbohydrate catabolic process GO:0044275 25 12 0,000 5,756E-03 0,01174315 ! dicarboxylic acid transmembrane transporter activity GO:0005310 14 12 0,000 5,756E-03 0,01173658 ! CoA hydrolase activity GO:0016289 14 12 0,000 5,756E-03 0,01173003 ! histone acetyltransferase complex GO:0000123 14 12 0,000 5,756E-03 0,01172348 ! regulation of alpha-beta T cell differentiation GO:0046637 13 12 0,000 5,756E-03 0,01171693 ! alpha-beta T cell activation GO:0046631 14 12 0,000 5,756E-03 0,0117104 ! retinol binding GO:0019841 12 12 0,000 5,756E-03 0,01170387 ! regulation of organ growth GO:0046620 12 12 0,000 5,756E-03 0,01169735 ! regulation of natural killer cell mediated immunity GO:0002715 13 12 0,000 5,756E-03 0,01169084 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! vasoconstriction GO:0042310 13 12 0,000 5,756E-03 0,01168433 ! histone acetylation GO:0016573 13 12 0,000 5,756E-03 0,01167783 ! ribosome binding GO:0043022 13 12 0,000 5,756E-03 0,01167134 ! delayed rectifier potassium channel activity GO:0005251 14 12 0,000 5,756E-03 0,01166486 ! organic cation transmembrane transporter activity GO:0015101 12 12 0,000 5,756E-03 0,01165838 ! phosphate transmembrane transporter activity GO:0015114 14 12 0,000 5,756E-03 0,01165191 ! tissue regeneration GO:0042246 12 12 0,000 5,756E-03 0,01164545 ! sulfate transmembrane transporter activity GO:0015116 13 12 0,000 5,756E-03 0,01163899 ! adenylyltransferase activity GO:0070566 13 12 0,000 5,756E-03 0,01163255 ! germ cell nucleus GO:0043073 14 12 0,000 5,756E-03 0,0116261 ! trans-Golgi network transport vesicle membrane GO:0012510 16 12 0,000 5,756E-03 0,01161967 ! hexose transmembrane transporter activity GO:0015149 12 12 0,000 5,756E-03 0,01161324 ! hexosaminidase activity GO:0015929 12 12 0,000 5,756E-03 0,01160682 ! regulation of acute inflammatory response GO:0002673 12 12 0,000 5,756E-03 0,01160041 ! activation of NF-kappaB-inducing kinase activity GO:0007250 14 12 0,000 5,756E-03 0,01159401 ! transmembrane receptor protein serine/threonine kinase signaling protein activity GO:0005071 13 12 0,000 5,756E-03 0,01158761 ! dopamine metabolic process GO:0042417 15 12 0,000 5,756E-03 0,01158122 ! somatic diversification of immunoglobulins GO:0016445 12 12 0,000 5,756E-03 0,01157483 ! phosphoinositide 3-kinase activity GO:0035004 14 12 0,000 5,756E-03 0,01156845 ! insulin-like growth factor receptor binding GO:0005159 14 12 0,000 5,756E-03 0,01156208 ! bacterial binding GO:0008367 14 12 0,000 5,756E-03 0,01155572 ! steroid hydroxylase activity GO:0008395 12 12 0,000 5,756E-03 0,01154936 ! cardiac cell differentiation GO:0035051 16 12 0,000 5,756E-03 0,01154302 ! phosphoinositide 3-kinase complex GO:0005942 14 12 0,000 5,756E-03 0,01153667 ! localization within membrane GO:0051668 13 12 0,000 5,756E-03 0,01153034 ! microtubule-based flagellum GO:0009434 12 12 0,000 5,756E-03 0,01152401 ! axoneme part GO:0044447 12 12 0,000 5,756E-03 0,01151769 ! regulation of membrane protein ectodomain proteolysis GO:0051043 14 13 0,000 6,234E-03 0,01246799 ! neuron maturation GO:0042551 14 13 0,000 6,234E-03 0,01246116 ! positive regulation of small GTPase mediated signal transduction GO:0051057 26 13 0,000 6,234E-03 0,01245433 ! negative regulation of bone remodeling GO:0046851 15 13 0,000 6,234E-03 0,01244752 ! bone remodeling GO:0046849 14 13 0,000 6,234E-03 0,01244071 ! nicotinic acetylcholine-gated receptor-channel complex GO:0005892 13 13 0,000 6,234E-03 0,01243391 ! regulation of receptor-mediated endocytosis GO:0048259 15 13 0,000 6,234E-03 0,01242711 ! striated muscle thin filament GO:0005865 14 13 0,000 6,234E-03 0,01242033 ! patterning of blood vessels GO:0001569 15 13 0,000 6,234E-03 0,01241355 ! organelle fusion GO:0048284 16 13 0,000 6,234E-03 0,01240677 ! palate development GO:0060021 15 13 0,000 6,234E-03 0,01240001 ! induction of apoptosis via death domain receptors GO:0008625 16 13 0,000 6,234E-03 0,01239325 ! arginine metabolic process GO:0006525 14 13 0,000 6,234E-03 0,0123865 ! ER-Golgi intermediate compartment membrane GO:0033116 23 13 0,000 6,234E-03 0,01237976 ! tyrosine metabolic process GO:0006570 15 13 0,000 6,234E-03 0,01237302 ! response to retinoic acid GO:0032526 17 13 0,000 6,234E-03 0,01236629 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 15 13 0,000 6,234E-03 0,01235957 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lipase inhibitor activity GO:0055102 14 13 0,000 6,234E-03 0,01235286 ! negative regulation of endothelial cell migration GO:0010596 15 13 0,000 6,234E-03 0,01234615 ! fear response GO:0042596 15 13 0,000 6,234E-03 0,01233945 ! epithelial cell development GO:0002064 22 13 0,000 6,234E-03 0,01233276 ! branching involved in ureteric bud morphogenesis GO:0001658 14 13 0,000 6,234E-03 0,01232608 GO:0060675|ureteric bud morphogenesis, ! positive regulation of fatty acid metabolic process GO:0045923 14 13 0,000 6,234E-03 0,0123194 ! protein kinase activator activity GO:0030295 17 13 0,000 6,234E-03 0,01231273 ! heparan sulfate proteoglycan metabolic process GO:0030201 13 13 0,000 6,234E-03 0,01230607 ! positive regulation of foam cell differentiation GO:0010744 16 13 0,000 6,234E-03 0,01229941 ! protein targeting to peroxisome GO:0006625 13 13 0,000 6,234E-03 0,01229277 ! NLS-bearing substrate import into nucleus GO:0006607 15 13 0,000 6,234E-03 0,01228612 ! cranial nerve development GO:0021545 15 13 0,000 6,234E-03 0,01227949 ! eye photoreceptor cell differentiation GO:0001754 17 13 0,000 6,234E-03 0,01227286 GO:0042462|eye photoreceptor cell development, ! DNA-directed RNA polymerase II, core complex GO:0005665 14 13 0,000 6,234E-03 0,01226624 ! cerebellum morphogenesis GO:0021587 15 13 0,000 6,234E-03 0,01225963 ! MHC class I receptor activity GO:0032393 20 13 0,000 6,234E-03 0,01225303 ! exoribonuclease activity GO:0004532 13 13 0,000 6,234E-03 0,01224643 GO:0016896|exoribonuclease activity, producing 5'-phosphomonoesters, ! intrinsic to peroxisomal membrane GO:0031231 13 13 0,000 6,234E-03 0,01223984 ! COPI-coated vesicle GO:0030137 15 13 0,000 6,234E-03 0,01223325 ! cofactor transporter activity GO:0051184 15 13 0,000 6,234E-03 0,01222667 ! NADP metabolic process GO:0006739 15 13 0,000 6,234E-03 0,01222011 ! negative regulation of macrophage differentiation GO:0045650 16 13 0,000 6,234E-03 0,01221354 ! regulation of osteoclast differentiation GO:0045670 15 13 0,000 6,234E-03 0,01220699 ! aromatic amino acid family catabolic process GO:0009074 13 13 0,000 6,234E-03 0,01220044 ! eukaryotic cell surface binding GO:0043499 15 13 0,000 6,234E-03 0,0121939 ! proximal/distal pattern formation GO:0009954 15 13 0,000 6,234E-03 0,01218736 ! positive regulation of JNK cascade GO:0046330 17 13 0,000 6,234E-03 0,01218083 ! positive regulation of glucose import GO:0046326 16 13 0,000 6,234E-03 0,01217431 GO:0010828|positive regulation of glucose transport, ! epithelial to mesenchymal transition GO:0001837 13 13 0,000 6,234E-03 0,0121678 ! ADP binding GO:0043531 15 13 0,000 6,234E-03 0,01216129 ! defense response to Gram-positive bacterium GO:0050830 14 13 0,000 6,234E-03 0,01215479 ! mismatched DNA binding GO:0030983 13 13 0,000 6,234E-03 0,0121483 ! positive regulation of synaptic transmission GO:0050806 15 13 0,000 6,234E-03 0,01214181 ! neuron fate specification GO:0048665 25 13 0,000 6,234E-03 0,01213533 ! N-terminal protein amino acid modification GO:0031365 14 13 0,000 6,234E-03 0,01212886 ! dicarboxylic acid transport GO:0006835 15 13 0,000 6,234E-03 0,0121224 ! water transport GO:0006833 18 13 0,000 6,234E-03 0,01211594 GO:0042044|fluid transport, ! cytosolic calcium ion transport GO:0060401 20 13 0,000 6,234E-03 0,01210949 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 6,234E-03 0,01210304 ! inorganic anion exchanger activity GO:0005452 13 13 0,000 6,234E-03 0,0120966 ! negative regulation of ion transport GO:0043271 15 13 0,000 6,234E-03 0,01209017 ! retinoic acid receptor binding GO:0042974 14 13 0,000 6,234E-03 0,01208375 ! blood vessel remodeling GO:0001974 16 13 0,000 6,234E-03 0,01207733 ! myoblast differentiation GO:0045445 15 13 0,000 6,234E-03 0,01207092 ! ventral spinal cord development GO:0021517 16 13 0,000 6,234E-03 0,01206452 ! prenyltransferase activity GO:0004659 15 13 0,000 6,234E-03 0,01205812 ! activation of MAPKK activity GO:0000186 13 13 0,000 6,234E-03 0,01205173 ! protein histidine kinase activity GO:0004673 15 13 0,000 6,234E-03 0,01204535 GO:0000155|two-component sensor activity, ! cullin-RING ubiquitin ligase complex GO:0031461 13 13 0,000 6,234E-03 0,01203897 ! regulation of skeletal muscle fiber development GO:0048742 16 13 0,000 6,234E-03 0,0120326 ! acyl-CoA dehydrogenase activity GO:0003995 14 13 0,000 6,234E-03 0,01202624 ! exocrine system development GO:0035272 14 13 0,000 6,234E-03 0,01201988 ! membrane protein proteolysis GO:0033619 14 13 0,000 6,234E-03 0,01201353 GO:0006509|membrane protein ectodomain proteolysis, ! organic alcohol transport GO:0015850 17 13 0,000 6,234E-03 0,01200719 ! calcium ion transmembrane transporter activity GO:0015085 15 13 0,000 6,234E-03 0,01200085 ! L-glutamate transport GO:0015813 14 13 0,000 6,234E-03 0,01199452 GO:0015800|acidic amino acid transport, ! embryo implantation GO:0007566 17 13 0,000 6,234E-03 0,0119882 ! G1/S transition checkpoint GO:0031575 14 13 0,000 6,234E-03 0,01198188 ! immunoglobulin binding GO:0019865 14 13 0,000 6,234E-03 0,01197557 ! negative regulation of protein import into nucleus GO:0042308 13 13 0,000 6,234E-03 0,01196927 ! regulation of T cell mediated immunity GO:0002709 17 13 0,000 6,234E-03 0,01196297 ! genitalia development GO:0048806 18 13 0,000 6,234E-03 0,01195669 ! regulation of interleukin-8 production GO:0032677 15 13 0,000 6,234E-03 0,0119504 ! regulation of interleukin-12 production GO:0032655 13 13 0,000 6,234E-03 0,01194413 ! MHC class I protein binding GO:0042288 23 13 0,000 6,234E-03 0,01193786 ! histone deacetylation GO:0016575 14 13 0,000 6,234E-03 0,01193159 ! calcium channel regulator activity GO:0005246 16 13 0,000 6,234E-03 0,01192534 ! DNA methylation GO:0006306 15 13 0,000 6,234E-03 0,01191909 GO:0006305|DNA alkylation, ! mRNA splice site selection GO:0006376 17 13 0,000 6,234E-03 0,01191284 ! chromatin silencing GO:0006342 13 13 0,000 6,234E-03 0,0119066 ! serotonin receptor activity GO:0004993 16 13 0,000 6,234E-03 0,01190037 ! monosaccharide transmembrane transporter activity GO:0015145 13 13 0,000 6,234E-03 0,01189415 ! peptide biosynthetic process GO:0043043 14 13 0,000 6,234E-03 0,01188793 ! diacylglycerol kinase activity GO:0004143 15 13 0,000 6,234E-03 0,01188172 ! response to gamma radiation GO:0010332 14 13 0,000 6,234E-03 0,01187552 ! synaptic transmission, cholinergic GO:0007271 14 13 0,000 6,234E-03 0,01186932 ! retinoic acid receptor activity GO:0003708 15 13 0,000 6,234E-03 0,01186313 ! purine base metabolic process GO:0006144 15 13 0,000 6,234E-03 0,01185694 ! cAMP binding GO:0030552 15 13 0,000 6,234E-03 0,01185076 ! biogenic amine catabolic process GO:0042402 14 13 0,000 6,234E-03 0,01184459 ! negative regulation of BMP signaling pathway GO:0030514 14 13 0,000 6,234E-03 0,01183843 ! regulation of axon extension GO:0030516 16 13 0,000 6,234E-03 0,01183227 ! drug transporter activity GO:0015238 14 13 0,000 6,234E-03 0,01182611 ! regulation of NF-kappaB import into nucleus GO:0042345 14 13 0,000 6,234E-03 0,01181997 ! calcium-activated potassium channel activity GO:0015269 15 13 0,000 6,234E-03 0,01181383 ! response to cold GO:0009409 13 13 0,000 6,234E-03 0,01180769 ! cadherin binding GO:0045296 16 13 0,000 6,234E-03 0,01180156 ! nucleolar part GO:0044452 13 13 0,000 6,234E-03 0,01179544 ! tRNA modification GO:0006400 14 14 0,000 6,712E-03 0,01269349 ! cis-Golgi network GO:0005801 16 14 0,000 6,712E-03 0,01268691 ! negative regulation of hormone secretion GO:0046888 14 14 0,000 6,712E-03 0,01268034 ! 'de novo' protein folding GO:0006458 14 14 0,000 6,712E-03 0,01267378 ! organellar large ribosomal subunit GO:0000315 15 14 0,000 6,712E-03 0,01266722 GO:0005762|mitochondrial large ribosomal subunit, ! phosphoinositide phosphorylation GO:0046854 18 14 0,000 6,712E-03 0,01266067 ! peroxisomal transport GO:0043574 14 14 0,000 6,712E-03 0,01265413 ! cardiac muscle contraction GO:0060048 15 14 0,000 6,712E-03 0,01264759 ! dopamine receptor signaling pathway GO:0007212 19 14 0,000 6,712E-03 0,01264106 ! mechanoreceptor differentiation GO:0042490 16 14 0,000 6,712E-03 0,01263454 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 18 14 0,000 6,712E-03 0,01262802 ! negative regulation of peptidase activity GO:0010466 16 14 0,000 6,712E-03 0,01262152 ! pseudouridine synthesis GO:0001522 14 14 0,000 6,712E-03 0,01261501 ! positive regulation of cell growth GO:0030307 15 14 0,000 6,712E-03 0,01260852 ! caspase activator activity GO:0008656 16 14 0,000 6,712E-03 0,01260203 ! MHC class II protein complex GO:0042613 19 14 0,000 6,712E-03 0,01259554 ! regulation of defense response to virus GO:0050688 24 14 0,000 6,712E-03 0,01258907 ! cAMP-dependent protein kinase regulator activity GO:0008603 17 14 0,000 6,712E-03 0,0125826 ! cation:cation antiporter activity GO:0015491 14 14 0,000 6,712E-03 0,01257614 ! glycoprotein catabolic process GO:0006516 16 14 0,000 6,712E-03 0,01256968 ! protein polyubiquitination GO:0000209 15 14 0,000 6,712E-03 0,01256323 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 34 14 0,000 6,712E-03 0,01255679 ! cell-cell junction assembly GO:0007043 15 14 0,000 6,712E-03 0,01255035 ! response to vitamin A GO:0033189 18 14 0,000 6,712E-03 0,01254392 ! actin filament bundle formation GO:0051017 16 14 0,000 6,712E-03 0,0125375 ! regulation of lipoprotein lipase activity GO:0051004 15 14 0,000 6,712E-03 0,01253108 ! plasma membrane fusion GO:0045026 15 14 0,000 6,712E-03 0,01252467 ! purine nucleoside monophosphate metabolic process GO:0009126 15 14 0,000 6,712E-03 0,01251827 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of viral reproduction GO:0050792 16 14 0,000 6,712E-03 0,01251187 ! protein export from nucleus GO:0006611 14 14 0,000 6,712E-03 0,01250548 ! presynaptic membrane GO:0042734 14 14 0,000 6,712E-03 0,0124991 ! negative regulation of immune response GO:0050777 21 14 0,000 6,712E-03 0,01249272 ! gastrulation with mouth forming second GO:0001702 15 14 0,000 6,712E-03 0,01248635 ! neural crest cell migration GO:0001755 15 14 0,000 6,712E-03 0,01247999 ! anaphase-promoting complex GO:0005680 17 14 0,000 6,712E-03 0,01247363 ! positive regulation of oxidoreductase activity GO:0051353 14 14 0,000 6,712E-03 0,01246728 ! negative regulation of protein secretion GO:0050709 17 14 0,000 6,712E-03 0,01246094 ! cofactor transport GO:0051181 16 14 0,000 6,712E-03 0,0124546 ! C21-steroid hormone biosynthetic process GO:0006700 14 14 0,000 6,712E-03 0,01244827 ! protein-chromophore linkage GO:0018298 16 14 0,000 6,712E-03 0,01244194 ! cobalt ion binding GO:0050897 14 14 0,000 6,712E-03 0,01243562 ! glutamine family amino acid biosynthetic process GO:0009084 16 14 0,000 6,712E-03 0,01242931 ! positive regulation of transmission of nerve impulse GO:0051971 16 14 0,000 6,712E-03 0,012423 ! aspartate family amino acid biosynthetic process GO:0009067 17 14 0,000 6,712E-03 0,0124167 ! gas transport GO:0015669 15 14 0,000 6,712E-03 0,01241041 ! pyridine nucleotide biosynthetic process GO:0019363 15 14 0,000 6,712E-03 0,01240412 ! heme biosynthetic process GO:0006783 14 14 0,000 6,712E-03 0,01239784 ! release of cytochrome c from mitochondria GO:0001836 26 14 0,000 6,712E-03 0,01239157 ! cerebellar cortex development GO:0021695 16 14 0,000 6,712E-03 0,0123853 ! insulin secretion GO:0030073 17 14 0,000 6,712E-03 0,01237904 ! tRNA binding GO:0000049 16 14 0,000 6,712E-03 0,01237278 ! positive regulation of cell killing GO:0031343 16 14 0,000 6,712E-03 0,01236654 ! positive regulation of protein complex assembly GO:0031334 14 14 0,000 6,712E-03 0,01236029 ! G1 phase of mitotic cell cycle GO:0000080 15 14 0,000 6,712E-03 0,01235406 ! phosphatidylinositol metabolic process GO:0046488 15 14 0,000 6,712E-03 0,01234783 ! regulation of neuronal synaptic plasticity GO:0048168 24 14 0,000 6,712E-03 0,0123416 ! MAP kinase activity GO:0004707 16 14 0,000 6,712E-03 0,01233539 ! cytokine biosynthetic process GO:0042089 14 14 0,000 6,712E-03 0,01232917 ! mannosyltransferase activity GO:0000030 14 14 0,000 6,712E-03 0,01232297 ! isoprenoid biosynthetic process GO:0008299 17 14 0,000 6,712E-03 0,01231677 ! C-C chemokine binding GO:0019957 15 14 0,000 6,712E-03 0,01231058 GO:0016493|C-C chemokine receptor activity, ! cardiac muscle tissue development GO:0048738 16 14 0,000 6,712E-03 0,01230439 ! complement activation, alternative pathway GO:0006957 14 14 0,000 6,712E-03 0,01229821 ! response to osmotic stress GO:0006970 17 14 0,000 6,712E-03 0,01229204 ! fructose metabolic process GO:0006000 15 14 0,000 6,712E-03 0,01228587 ! telomeric DNA binding GO:0042162 17 14 0,000 6,712E-03 0,01227971 ! monoamine transport GO:0015844 15 14 0,000 6,712E-03 0,01227355 ! regulation of pathway-restricted SMAD protein phosphorylation GO:0060393 14 14 0,000 6,712E-03 0,0122674 ! nucleoside kinase activity GO:0019206 17 14 0,000 6,712E-03 0,01226126 ! dendritic spine GO:0043197 15 14 0,000 6,712E-03 0,01225512 ! stem cell development GO:0048864 14 14 0,000 6,712E-03 0,01224899 GO:0019827|stem cell maintenance, ! regulation of alpha-beta T cell activation GO:0046634 15 14 0,000 6,712E-03 0,01224287 ! regulation of insulin receptor signaling pathway GO:0046626 17 14 0,000 6,712E-03 0,01223675 ! regulation of cytokine production during immune response GO:0002718 15 14 0,000 6,712E-03 0,01223064 ! positive regulation of protein import into nucleus GO:0042307 16 14 0,000 6,712E-03 0,01222453 ! regulation of cellular pH GO:0030641 14 14 0,000 6,712E-03 0,01221843 ! regulation of monooxygenase activity GO:0032768 14 14 0,000 6,712E-03 0,01221234 ! intracellular ligand-gated ion channel activity GO:0005217 14 14 0,000 6,712E-03 0,01220625 ! sarcoplasmic reticulum membrane GO:0033017 16 14 0,000 6,712E-03 0,01220017 ! detection of biotic stimulus GO:0009595 16 14 0,000 6,712E-03 0,01219409 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity GO:0015932 16 14 0,000 6,712E-03 0,01218802 ! mannosidase activity GO:0015923 19 14 0,000 6,712E-03 0,01218196 ! calcium-dependent cysteine-type endopeptidase activity GO:0004198 17 14 0,000 6,712E-03 0,0121759 ! negative regulation of tissue remodeling GO:0034104 16 14 0,000 6,712E-03 0,01216985 ! positive regulation of bone mineralization GO:0030501 14 14 0,000 6,712E-03 0,0121638 ! neuromuscular synaptic transmission GO:0007274 15 14 0,000 6,712E-03 0,01215777 ! regulation of immunoglobulin production GO:0002637 15 14 0,000 6,712E-03 0,01215173 ! cAMP biosynthetic process GO:0006171 14 14 0,000 6,712E-03 0,0121457 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 16 14 0,000 6,712E-03 0,01213968 ! fucosyltransferase activity GO:0008417 16 14 0,000 6,712E-03 0,01213367 ! sperm-egg recognition GO:0035036 17 14 0,000 6,712E-03 0,01212766 GO:0007339|binding of sperm to zona pellucida, ! defense response to virus GO:0051607 21 14 0,000 6,712E-03 0,01212165 ! SWI/SNF-type complex GO:0070603 16 14 0,000 6,712E-03 0,01211566 GO:0016514|SWI/SNF complex, ! aldo-keto reductase activity GO:0004033 15 14 0,000 6,712E-03 0,01210966 ! positive regulation of translation GO:0045727 17 15 0,000 7,19E-03 0,01296546 ! transferase activity, transferring amino-acyl groups GO:0016755 15 15 0,000 7,19E-03 0,01295905 ! 2'-deoxyribonucleotide metabolic process GO:0009394 16 15 0,000 7,19E-03 0,01295265 GO:0019692|deoxyribose phosphate metabolic process, ! phospholipid catabolic process GO:0009395 26 15 0,000 7,19E-03 0,01294626 ! endothelial cell migration GO:0043542 16 15 0,000 7,19E-03 0,01293987 ! lipid phosphorylation GO:0046834 19 15 0,000 7,19E-03 0,01293349 ! negative regulation of nucleocytoplasmic transport GO:0046823 15 15 0,000 7,19E-03 0,01292712 ! response to vitamin GO:0033273 19 15 0,000 7,19E-03 0,01292075 ! gene silencing by RNA GO:0031047 17 15 0,000 7,19E-03 0,01291439 ! striated muscle thick filament GO:0005863 16 15 0,000 7,19E-03 0,01290803 GO:0032982|myosin filament, ! cellular response to hydrogen peroxide GO:0070301 15 15 0,000 7,19E-03 0,01290168 GO:0042744|hydrogen peroxide catabolic process, ! endocrine pancreas development GO:0031018 16 15 0,000 7,19E-03 0,01289534 ! regulation of interleukin-2 biosynthetic process GO:0045076 15 15 0,000 7,19E-03 0,012889 ! glutamate metabolic process GO:0006536 17 15 0,000 7,19E-03 0,01288267 ! pituitary gland development GO:0021983 16 15 0,000 7,19E-03 0,01287635 ! cholesterol binding GO:0015485 15 15 0,000 7,19E-03 0,01287003 ! NAD metabolic process GO:0019674 17 15 0,000 7,19E-03 0,01286372 ! protease binding GO:0002020 20 15 0,000 7,19E-03 0,01285741 ! regulation of heart rate GO:0002027 20 15 0,000 7,19E-03 0,01285111 ! actin filament bundle GO:0032432 18 15 0,000 7,19E-03 0,01284482 GO:0001725|stress fiber, ! Golgi cisterna GO:0031985 17 15 0,000 7,19E-03 0,01283853 ! regulation of exocytosis GO:0017157 16 15 0,000 7,19E-03 0,01283225 ! positive regulation of axonogenesis GO:0050772 16 15 0,000 7,19E-03 0,01282597 ! embryonic digit morphogenesis GO:0042733 17 15 0,000 7,19E-03 0,01281971 ! positive regulation of biomineral formation GO:0070169 15 15 0,000 7,19E-03 0,01281344 ! prostaglandin metabolic process GO:0006693 15 15 0,000 7,19E-03 0,01280719 GO:0006692|prostanoid metabolic process, ! postsynaptic density GO:0014069 20 15 0,000 7,19E-03 0,01280094 ! neuron recognition GO:0008038 18 15 0,000 7,19E-03 0,01279469 ! regulation of Rho GTPase activity GO:0032319 18 15 0,000 7,19E-03 0,01278845 ! hindbrain morphogenesis GO:0021575 18 15 0,000 7,19E-03 0,01278222 ! filopodium GO:0030175 17 15 0,000 7,19E-03 0,01277599 ! negative regulation of blood coagulation GO:0030195 18 15 0,000 7,19E-03 0,01276977 ! folic acid and derivative metabolic process GO:0006760 15 15 0,000 7,19E-03 0,01276356 ! positive regulation of neuron differentiation GO:0045666 27 15 0,000 7,19E-03 0,01275735 ! peptide hormone binding GO:0017046 16 15 0,000 7,19E-03 0,01275115 ! regulation of ATPase activity GO:0043462 17 15 0,000 7,19E-03 0,01274495 ! endoribonuclease activity, producing 3'-phosphomonoesters GO:0016892 16 15 0,000 7,19E-03 0,01273877 ! regulation of leukocyte mediated cytotoxicity GO:0001910 21 15 0,000 7,19E-03 0,01273258 ! acid-thiol ligase activity GO:0016878 16 15 0,000 7,19E-03 0,0127264 ! aromatic compound biosynthetic process GO:0019438 25 15 0,000 7,19E-03 0,01272023 ! positive regulation of calcium ion transport GO:0051928 20 15 0,000 7,19E-03 0,01271407 ! dystrophin-associated glycoprotein complex GO:0016010 17 15 0,000 7,19E-03 0,01270791 ! RNA 3'-end processing GO:0031123 16 15 0,000 7,19E-03 0,01270175 ! developmental induction GO:0031128 17 15 0,000 7,19E-03 0,0126956 GO:0045168|cell-cell signaling involved in cell fate specification, ! protein import into nucleus, docking GO:0000059 15 15 0,000 7,19E-03 0,01268946 ! regulation of skeletal muscle tissue development GO:0048641 18 15 0,000 7,19E-03 0,01268333 ! lactation GO:0007595 17 15 0,000 7,19E-03 0,0126772 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 16 15 0,000 7,19E-03 0,01267107 GO:0016444|somatic cell DNA recombination, ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 7,19E-03 0,01266495 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 7,19E-03 0,01265884 ! double-strand break repair via homologous recombination GO:0000724 36 15 0,000 7,19E-03 0,01265273 GO:0000725|recombinational repair, ! phosphatidylcholine metabolic process GO:0046470 16 15 0,000 7,19E-03 0,01264663 ! regulation of cell-cell adhesion GO:0022407 18 15 0,000 7,19E-03 0,01264054 ! sulfate transport GO:0008272 16 15 0,000 7,19E-03 0,01263445 ! hindlimb morphogenesis GO:0035137 17 15 0,000 7,19E-03 0,01262837 ! bile acid metabolic process GO:0008206 17 15 0,000 7,19E-03 0,01262229 ! very-low-density lipoprotein particle GO:0034361 16 15 0,000 7,19E-03 0,01261622 GO:0034385|triglyceride-rich lipoprotein particle, ! adult walking behavior GO:0007628 19 15 0,000 7,19E-03 0,01261015 ! 2 iron, 2 sulfur cluster binding GO:0051537 16 15 0,000 7,19E-03 0,01260409 ! heart looping GO:0001947 18 15 0,000 7,19E-03 0,01259804 ! protein kinase C activity GO:0004697 17 15 0,000 7,19E-03 0,01259199 ! oligodendrocyte differentiation GO:0048709 15 15 0,000 7,19E-03 0,01258595 ! regulation of striated muscle contraction GO:0006942 18 15 0,000 7,19E-03 0,01257991 ! pigmentation during development GO:0048066 17 15 0,000 7,19E-03 0,01257388 ! cytokine metabolic process GO:0042107 15 15 0,000 7,19E-03 0,01256786 ! vesicle coating GO:0006901 17 15 0,000 7,19E-03 0,01256184 ! disulfide oxidoreductase activity GO:0015036 16 15 0,000 7,19E-03 0,01255582 ! neutral amino acid transport GO:0015804 18 15 0,000 7,19E-03 0,01254982 ! L-amino acid transport GO:0015807 16 15 0,000 7,19E-03 0,01254382 ! microfilament motor activity GO:0000146 15 15 0,000 7,19E-03 0,01253782 ! carbonate dehydratase activity GO:0004089 18 15 0,000 7,19E-03 0,01253183 ! regulation of vasodilation GO:0042312 25 15 0,000 7,19E-03 0,01252584 ! taste receptor activity GO:0008527 15 15 0,000 7,19E-03 0,01251987 ! cellular pigmentation GO:0033059 16 15 0,000 7,19E-03 0,01251389 ! voltage-gated chloride channel activity GO:0005247 18 15 0,000 7,19E-03 0,01250792 ! voltage-gated sodium channel activity GO:0005248 18 15 0,000 7,19E-03 0,01250196 ! long-chain fatty acid transport GO:0015909 17 15 0,000 7,19E-03 0,01249601 ! positive regulation of neurological system process GO:0031646 18 15 0,000 7,19E-03 0,01249006 ! nerve-nerve synaptic transmission GO:0007270 17 15 0,000 7,19E-03 0,01248411 ! ARF guanyl-nucleotide exchange factor activity GO:0005086 17 15 0,000 7,19E-03 0,01247817 ! ion gated channel activity GO:0022839 17 15 0,000 7,19E-03 0,01247224 ! heterogeneous nuclear ribonucleoprotein complex GO:0030530 15 15 0,000 7,19E-03 0,01246631 ! receptor activator activity GO:0030546 17 15 0,000 7,19E-03 0,01246039 ! protein transmembrane transporter activity GO:0008320 16 15 0,000 7,19E-03 0,01245447 ! negative regulation of mast cell proliferation GO:0070667 16 15 0,000 7,19E-03 0,01244856 GO:0042130|negative regulation of T cell proliferation, ! acylglycerol O-acyltransferase activity GO:0016411 16 15 0,000 7,19E-03 0,01244266 ! triacylglycerol lipase activity GO:0004806 16 15 0,000 7,19E-03 0,01243676 ! peptide hormone processing GO:0016486 19 15 0,000 7,19E-03 0,01243086 ! phospholipid-translocating ATPase activity GO:0004012 16 15 0,000 7,19E-03 0,01242497 GO:0015247|aminophospholipid transporter activity, ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 19 16 0,000 7,668E-03 0,0132442 ! positive regulation of anti-apoptosis GO:0045768 16 16 0,000 7,668E-03 0,01323793 ! phosphotransferase activity, nitrogenous group as acceptor GO:0016775 18 16 0,000 7,668E-03 0,01323167 ! heterophilic cell adhesion GO:0007157 17 16 0,000 7,668E-03 0,01322541 ! gamma-aminobutyric acid signaling pathway GO:0007214 17 16 0,000 7,668E-03 0,01321916 ! kinesin complex GO:0005871 16 16 0,000 7,668E-03 0,01321292 ! photoreceptor cell development GO:0042461 22 16 0,000 7,668E-03 0,01320668 GO:0046530|photoreceptor cell differentiation, ! negative regulation of gene expression, epigenetic GO:0045814 16 16 0,000 7,668E-03 0,01320045 ! mitotic chromosome condensation GO:0007076 17 16 0,000 7,668E-03 0,01319422 ! centrosome cycle GO:0007098 26 16 0,000 7,668E-03 0,013188 ! negative regulation of epithelial cell proliferation GO:0050680 18 16 0,000 7,668E-03 0,01318179 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 16 0,000 7,668E-03 0,01317558 ! cerebral cortex development GO:0021987 16 16 0,000 7,668E-03 0,01316937 ! lysosomal transport GO:0007041 16 16 0,000 7,668E-03 0,01316318 ! transforming growth factor beta receptor activity GO:0005024 18 16 0,000 7,668E-03 0,01315698 GO:0004675|transmembrane receptor protein serine/threonine kinase activity, ! rough endoplasmic reticulum GO:0005791 16 16 0,000 7,668E-03 0,0131508 ! mitochondrial proton-transporting ATP synthase complex GO:0005753 16 16 0,000 7,668E-03 0,01314462 ! small nucleolar ribonucleoprotein complex GO:0005732 16 16 0,000 7,668E-03 0,01313845 ! myofibril assembly GO:0030239 17 16 0,000 7,668E-03 0,01313228 GO:0055002|striated muscle cell development, ! G1 phase GO:0051318 17 16 0,000 7,668E-03 0,01312611 ! receptor signaling complex scaffold activity GO:0030159 19 16 0,000 7,668E-03 0,01311996 ! negative regulation of inflammatory response GO:0050728 17 16 0,000 7,668E-03 0,01311381 ! clathrin vesicle coat GO:0030125 20 16 0,000 7,668E-03 0,01310766 ! endodeoxyribonuclease activity GO:0004520 43 16 0,000 7,668E-03 0,01310152 ! sphingolipid catabolic process GO:0030149 18 16 0,000 7,668E-03 0,01309539 GO:0046466|membrane lipid catabolic process, ! natural killer cell activation GO:0030101 17 16 0,000 7,668E-03 0,01308926 ! steroid catabolic process GO:0006706 18 16 0,000 7,668E-03 0,01308314 ! branched chain family amino acid metabolic process GO:0009081 18 16 0,000 7,668E-03 0,01307702 ! cell-cell recognition GO:0009988 19 16 0,000 7,668E-03 0,01307091 ! somatic diversification of immune receptors GO:0002200 17 16 0,000 7,668E-03 0,01306481 ! spleen development GO:0048536 19 16 0,000 7,668E-03 0,01305871 ! regulation of fatty acid oxidation GO:0046320 19 16 0,000 7,668E-03 0,01305261 ! neural tube closure GO:0001843 19 16 0,000 7,668E-03 0,01304653 GO:0060606|tube closure, ! antigen receptor-mediated signaling pathway GO:0050851 22 16 0,000 7,668E-03 0,01304044 ! regulation of protein ubiquitination GO:0031396 27 16 0,000 7,668E-03 0,01303437 ! regulation of glucose metabolic process GO:0010906 18 16 0,000 7,668E-03 0,0130283 ! regulation of lipid catabolic process GO:0050994 18 16 0,000 7,668E-03 0,01302223 ! viral genome replication GO:0019079 16 16 0,000 7,668E-03 0,01301617 ! regulation of neurotransmitter transport GO:0051588 19 16 0,000 7,668E-03 0,01301012 ! memory GO:0007613 18 16 0,000 7,668E-03 0,01300407 ! regulation of carbohydrate biosynthetic process GO:0043255 17 16 0,000 7,668E-03 0,01299802 ! positive regulation of ion transport GO:0043270 21 16 0,000 7,668E-03 0,01299199 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 18 16 0,000 7,668E-03 0,01298596 ! glycoprotein binding GO:0001948 19 16 0,000 7,668E-03 0,01297993 ! negative regulation of endothelial cell proliferation GO:0001937 17 16 0,000 7,668E-03 0,01297391 ! syntaxin binding GO:0019905 18 16 0,000 7,668E-03 0,0129679 ! myosin binding GO:0017022 17 16 0,000 7,668E-03 0,01296189 ! epidermis morphogenesis GO:0048730 18 16 0,000 7,668E-03 0,01295588 ! fucose metabolic process GO:0006004 18 16 0,000 7,668E-03 0,01294988 ! actin polymerization or depolymerization GO:0008154 18 16 0,000 7,668E-03 0,01294389 ! membrane budding GO:0006900 18 16 0,000 7,668E-03 0,0129379 ! preassembly of GPI anchor in ER membrane GO:0016254 18 16 0,000 7,668E-03 0,01293192 ! intermediate filament cytoskeleton organization GO:0045104 16 16 0,000 7,668E-03 0,01292595 ! behavioral interaction between organisms GO:0051705 19 16 0,000 7,668E-03 0,01291998 ! anchored to plasma membrane GO:0046658 20 16 0,000 7,668E-03 0,01291401 ! calcium activated cation channel activity GO:0005227 18 16 0,000 7,668E-03 0,01290805 ! DNA fragmentation involved in apoptosis GO:0006309 18 16 0,000 7,668E-03 0,0129021 ! apoptotic protease activator activity GO:0016505 18 16 0,000 7,668E-03 0,01289615 ! sulfuric ester hydrolase activity GO:0008484 18 16 0,000 7,668E-03 0,01289021 ! nicotinic acetylcholine-activated cation-selective channel activity GO:0004889 18 16 0,000 7,668E-03 0,01288427 ! purine nucleotide catabolic process GO:0006195 16 16 0,000 7,668E-03 0,01287834 ! RNA polymerase II transcription mediator activity GO:0016455 19 16 0,000 7,668E-03 0,01287241 ! axoneme GO:0005930 16 16 0,000 7,668E-03 0,01286649 ! negative regulation of homeostatic process GO:0032845 19 16 0,000 7,668E-03 0,01286057 ! anion exchanger activity GO:0015380 17 17 0,000 8,145E-03 0,01365516 ! positive regulation of hormone secretion GO:0046887 19 17 0,000 8,145E-03 0,01364889 ! skin development GO:0043588 20 17 0,000 8,145E-03 0,01364262 ! phosphotransferase activity, for other substituted phosphate groups GO:0016780 17 17 0,000 8,145E-03 0,01363636 ! transcription from RNA polymerase III promoter GO:0006383 18 17 0,000 8,145E-03 0,01363011 ! glial cell development GO:0021782 17 17 0,000 8,145E-03 0,01362386 ! limbic system development GO:0021761 18 17 0,000 8,145E-03 0,01361762 ! protein phosphatase type 2A regulator activity GO:0008601 19 17 0,000 8,145E-03 0,01361138 ! pyrimidine ribonucleotide metabolic process GO:0009218 20 17 0,000 8,145E-03 0,01360514 ! ephrin receptor activity GO:0005003 21 17 0,000 8,145E-03 0,01359892 ! acetylcholine receptor activity GO:0015464 18 17 0,000 8,145E-03 0,0135927 ! glutamine metabolic process GO:0006541 26 17 0,000 8,145E-03 0,01358648 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor GO:0016646 21 17 0,000 8,145E-03 0,01358027 ! oxidoreductase activity, acting on the CH-NH2 group of donors GO:0016638 37 17 0,000 8,145E-03 0,01357407 ! signal sequence binding GO:0005048 18 17 0,000 8,145E-03 0,01356787 ! cell-substrate junction assembly GO:0007044 21 17 0,000 8,145E-03 0,01356168 ! proton-transporting two-sector ATPase complex, catalytic domain GO:0033178 17 17 0,000 8,145E-03 0,01355549 ! organelle subcompartment GO:0031984 19 17 0,000 8,145E-03 0,01354931 ! regulation of dephosphorylation GO:0035303 20 17 0,000 8,145E-03 0,01354313 ! regulation of vasoconstriction GO:0019229 21 17 0,000 8,145E-03 0,01353696 ! membrane depolarization GO:0051899 19 17 0,000 8,145E-03 0,0135308 ! oogenesis GO:0048477 20 17 0,000 8,145E-03 0,01352464 ! nuclear outer membrane GO:0005640 21 17 0,000 8,145E-03 0,01351849 ! regulation of immunoglobulin mediated immune response GO:0002889 18 17 0,000 8,145E-03 0,01351234 GO:0002712|regulation of B cell mediated immunity, ! immunoglobulin production GO:0002377 21 17 0,000 8,145E-03 0,0135062 GO:0002440|production of molecular mediator of immune response, ! positive regulation of cellular carbohydrate metabolic process GO:0010676 18 17 0,000 8,145E-03 0,01350006 ! positive regulation of macrophage differentiation GO:0045651 21 17 0,000 8,145E-03 0,01349393 ! organic cation transport GO:0015695 17 17 0,000 8,145E-03 0,01348781 ! porphyrin biosynthetic process GO:0006779 17 17 0,000 8,145E-03 0,01348169 GO:0033014|tetrapyrrole biosynthetic process, ! phosphatidylinositol binding GO:0005545 21 17 0,000 8,145E-03 0,01347557 ! hyaluronic acid binding GO:0005540 19 17 0,000 8,145E-03 0,01346946 ! regulation of mitotic metaphase/anaphase transition GO:0030071 18 17 0,000 8,145E-03 0,01346336 ! negative regulation of coagulation GO:0050819 20 17 0,000 8,145E-03 0,01345726 ! cellular monovalent inorganic cation homeostasis GO:0030004 18 17 0,000 8,145E-03 0,01345117 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 23 17 0,000 8,145E-03 0,01344508 ! positive regulation of smooth muscle cell proliferation GO:0048661 20 17 0,000 8,145E-03 0,013439 ! negative regulation of defense response GO:0031348 19 17 0,000 8,145E-03 0,01343293 ! lipid localization GO:0010876 19 17 0,000 8,145E-03 0,01342686 GO:0019915|lipid storage, ! tube lumen formation GO:0035148 20 17 0,000 8,145E-03 0,01342079 ! negative regulation of cytokine biosynthetic process GO:0042036 18 17 0,000 8,145E-03 0,01341473 ! regulation of systemic arterial blood pressure by hormone GO:0001990 17 17 0,000 8,145E-03 0,01340868 GO:0050886|endocrine process, ! MAP kinase kinase kinase activity GO:0004709 19 17 0,000 8,145E-03 0,01340263 ! negative regulation of protein amino acid phosphorylation GO:0001933 19 17 0,000 8,145E-03 0,01339659 ! protein phosphatase type 2A complex GO:0000159 21 17 0,000 8,145E-03 0,01339055 ! polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 22 17 0,000 8,145E-03 0,01338452 ! response to hexose stimulus GO:0009746 20 17 0,000 8,145E-03 0,01337849 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! transmembrane receptor protein phosphatase activity GO:0019198 24 17 0,000 8,145E-03 0,01337247 GO:0005001|transmembrane receptor protein tyrosine phosphatase activity, ! positive regulation of nitric oxide biosynthetic process GO:0045429 18 17 0,000 8,145E-03 0,01336646 ! AMP binding GO:0016208 19 17 0,000 8,145E-03 0,01336045 ! UDP-galactosyltransferase activity GO:0035250 19 17 0,000 8,145E-03 0,01335444 ! receptor metabolic process GO:0043112 20 17 0,000 8,145E-03 0,01334844 ! neurotransmitter metabolic process GO:0042133 20 17 0,000 8,145E-03 0,01334245 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 23 17 0,000 8,145E-03 0,01333646 ! alcohol binding GO:0043178 20 17 0,000 8,145E-03 0,01333048 ! T cell differentiation in the thymus GO:0033077 28 17 0,000 8,145E-03 0,0133245 ! visual learning GO:0008542 31 17 0,000 8,145E-03 0,01331853 ! structural constituent of eye lens GO:0005212 20 17 0,000 8,145E-03 0,01331256 ! cellular amino acid derivative catabolic process GO:0042219 19 17 0,000 8,145E-03 0,0133066 ! neutrophil chemotaxis GO:0030593 17 17 0,000 8,145E-03 0,01330064 ! protein localization in mitochondrion GO:0070585 19 17 0,000 8,145E-03 0,01329469 GO:0006626|protein targeting to mitochondrion, ! aspartic-type endopeptidase activity GO:0004190 18 17 0,000 8,145E-03 0,01328875 GO:0070001|aspartic-type peptidase activity, ! neutral amino acid transmembrane transporter activity GO:0015175 19 17 0,000 8,145E-03 0,01328281 ! proton-transporting ATP synthase complex GO:0045259 17 17 0,000 8,145E-03 0,01327687 ! translation elongation factor activity GO:0003746 19 17 0,000 8,145E-03 0,01327094 ! histone binding GO:0042393 26 17 0,000 8,145E-03 0,01326502 ! cilium assembly GO:0042384 18 17 0,000 8,145E-03 0,0132591 ! transforming growth factor beta receptor binding GO:0005160 19 17 0,000 8,145E-03 0,01325318 ! positive regulation of homeostatic process GO:0032846 23 17 0,000 8,145E-03 0,01324727 ! solute:hydrogen antiporter activity GO:0015299 18 17 0,000 8,145E-03 0,01324137 ! protein secretion GO:0009306 19 18 0,000 8,622E-03 0,01401104 ! positive regulation of cell size GO:0045793 19 18 0,000 8,622E-03 0,0140048 ! positive regulation of ossification GO:0045778 19 18 0,000 8,622E-03 0,01399857 ! positive regulation of angiogenesis GO:0045766 19 18 0,000 8,622E-03 0,01399234 ! organellar small ribosomal subunit GO:0000314 18 18 0,000 8,622E-03 0,01398612 GO:0005763|mitochondrial small ribosomal subunit, ! protein amino acid deacetylation GO:0006476 19 18 0,000 8,622E-03 0,0139799 ! protein amino acid acetylation GO:0006473 21 18 0,000 8,622E-03 0,01397369 ! positive regulation of nucleocytoplasmic transport GO:0046824 20 18 0,000 8,622E-03 0,01396749 ! cAMP metabolic process GO:0046058 18 18 0,000 8,622E-03 0,01396129 ! regulation of muscle cell differentiation GO:0051147 21 18 0,000 8,622E-03 0,01395509 ! cornified envelope GO:0001533 22 18 0,000 8,622E-03 0,0139489 ! retinoid metabolic process GO:0001523 19 18 0,000 8,622E-03 0,01394272 GO:0016101|diterpenoid metabolic process, ! actomyosin GO:0042641 21 18 0,000 8,622E-03 0,01393654 ! positive regulation of proteolysis GO:0045862 20 18 0,000 8,622E-03 0,01393037 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628 21 18 0,000 8,622E-03 0,0139242 ! calcium-dependent protein binding GO:0048306 20 18 0,000 8,622E-03 0,01391804 ! proton-transporting ATPase activity, rotational mechanism GO:0046961 18 18 0,000 8,622E-03 0,01391189 ! proton-transporting V-type ATPase complex GO:0033176 18 18 0,000 8,622E-03 0,01390574 ! pyrimidine ribonucleoside metabolic process GO:0046131 23 18 0,000 8,622E-03 0,01389959 ! regulation of ion transmembrane transporter activity GO:0032412 21 18 0,000 8,622E-03 0,01389345 ! positive regulation of carbohydrate metabolic process GO:0045913 19 18 0,000 8,622E-03 0,01388732 ! primary neural tube formation GO:0014020 21 18 0,000 8,622E-03 0,01388119 ! recycling endosome GO:0055037 22 18 0,000 8,622E-03 0,01387507 ! muscle cell development GO:0055001 20 18 0,000 8,622E-03 0,01386895 ! kinase activator activity GO:0019209 22 18 0,000 8,622E-03 0,01386284 ! positive regulation of T cell differentiation GO:0045582 28 18 0,000 8,622E-03 0,01385673 ! cerebellum development GO:0021549 20 18 0,000 8,622E-03 0,01385063 ! positive regulation of multicellular organism growth GO:0040018 19 18 0,000 8,622E-03 0,01384453 ! somitogenesis GO:0001756 20 18 0,000 8,622E-03 0,01383844 ! transcription factor TFIID complex GO:0005669 19 18 0,000 8,622E-03 0,01383236 ! low-density lipoprotein binding GO:0030169 19 18 0,000 8,622E-03 0,01382628 ! positive regulation of cytokine secretion GO:0050715 21 18 0,000 8,622E-03 0,0138202 ! negative regulation of intracellular transport GO:0032387 20 18 0,000 8,622E-03 0,01381413 ! glutamine family amino acid catabolic process GO:0009065 21 18 0,000 8,622E-03 0,01380807 ! basal plasma membrane GO:0009925 21 18 0,000 8,622E-03 0,01380201 GO:0045178|basal part of cell, ! vitamin D receptor binding GO:0042809 20 18 0,000 8,622E-03 0,01379596 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters GO:0016894 19 18 0,000 8,622E-03 0,01378991 ! embryonic organ morphogenesis GO:0048562 22 18 0,000 8,622E-03 0,01378386 ! negative regulation of translation GO:0017148 31 18 0,000 8,622E-03 0,01377783 ! regulation of cell killing GO:0031341 24 18 0,000 8,622E-03 0,01377179 ! positive regulation of cellular catabolic process GO:0031331 20 18 0,000 8,622E-03 0,01376577 ! nuclear chromosome, telomeric region GO:0000784 30 18 0,000 8,622E-03 0,01375975 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 19 18 0,000 8,622E-03 0,01375373 ! intra-Golgi vesicle-mediated transport GO:0006891 20 18 0,000 8,622E-03 0,01374772 ! protein complex scaffold GO:0032947 22 18 0,000 8,622E-03 0,01374171 ! SNAP receptor activity GO:0005484 21 18 0,000 8,622E-03 0,01373571 ! dendrite development GO:0016358 22 18 0,000 8,622E-03 0,01372972 ! cell differentiation in spinal cord GO:0021515 21 18 0,000 8,622E-03 0,01372373 ! inactivation of MAPK activity GO:0000188 20 18 0,000 8,622E-03 0,01371774 ! calmodulin-dependent protein kinase activity GO:0004683 20 18 0,000 8,622E-03 0,01371176 ! D-ribose metabolic process GO:0006014 19 18 0,000 8,622E-03 0,01370579 ! nuclear ubiquitin ligase complex GO:0000152 31 18 0,000 8,622E-03 0,01369982 ! glucuronosyltransferase activity GO:0015020 18 18 0,000 8,622E-03 0,01369385 ! coreceptor activity GO:0015026 28 18 0,000 8,622E-03 0,01368789 ! response to fungus GO:0009620 18 18 0,000 8,622E-03 0,01368194 ! stem cell differentiation GO:0048863 18 18 0,000 8,622E-03 0,01367599 ! intermediate filament-based process GO:0045103 18 18 0,000 8,622E-03 0,01367005 ! heart process GO:0003015 19 18 0,000 8,622E-03 0,01366411 GO:0060047|heart contraction, ! mismatch repair GO:0006298 28 18 0,000 8,622E-03 0,01365818 ! vasodilation GO:0042311 20 18 0,000 8,622E-03 0,01365225 ! transport vesicle membrane GO:0030658 23 18 0,000 8,622E-03 0,01364632 ! MHC protein binding GO:0042287 30 18 0,000 8,622E-03 0,01364041 ! inward rectifier potassium channel activity GO:0005242 22 18 0,000 8,622E-03 0,01363449 ! chloride transmembrane transporter activity GO:0015108 19 18 0,000 8,622E-03 0,01362859 ! bicarbonate transmembrane transporter activity GO:0015106 18 18 0,000 8,622E-03 0,01362268 ! ionotropic glutamate receptor activity GO:0004970 22 18 0,000 8,622E-03 0,01361679 ! cell-cell adherens junction GO:0005913 20 18 0,000 8,622E-03 0,0136109 ! negative regulation of leukocyte proliferation GO:0070664 20 18 0,000 8,622E-03 0,01360501 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! ubiquitin-specific protease activity GO:0004843 19 18 0,000 8,622E-03 0,01359913 ! ATP-dependent RNA helicase activity GO:0004004 28 18 0,000 8,622E-03 0,01359325 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 24 19 0,000 9,1E-03 0,01433917 ! pteridine and derivative metabolic process GO:0042558 29 19 0,000 9,1E-03 0,01433298 ! proteasome core complex GO:0005839 20 19 0,000 9,1E-03 0,01432679 ! hydrolase activity, hydrolyzing N-glycosyl compounds GO:0016799 22 19 0,000 9,1E-03 0,01432061 ! anion:anion antiporter activity GO:0015301 19 19 0,000 9,1E-03 0,01431444 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 24 19 0,000 9,1E-03 0,01430827 ! regulation of transmembrane transporter activity GO:0022898 22 19 0,000 9,1E-03 0,0143021 GO:0032409|regulation of transporter activity, ! regulation of survival gene product expression GO:0045884 23 19 0,000 9,1E-03 0,01429594 ! activation of pro-apoptotic gene products GO:0008633 26 19 0,000 9,1E-03 0,01428979 ! deoxyribonucleotide metabolic process GO:0009262 20 19 0,000 9,1E-03 0,01428364 ! lysosome organization GO:0007040 20 19 0,000 9,1E-03 0,01427749 ! cellular macromolecular complex disassembly GO:0034623 23 19 0,000 9,1E-03 0,01427136 ! central nervous system neuron development GO:0021954 21 19 0,000 9,1E-03 0,01426522 ! threonine-type endopeptidase activity GO:0004298 20 19 0,000 9,1E-03 0,0142591 GO:0070003|threonine-type peptidase activity, ! chromosome condensation GO:0030261 20 19 0,000 9,1E-03 0,01425297 ! peptidyl-serine phosphorylation GO:0018105 26 19 0,000 9,1E-03 0,01424686 ! regulation of endothelial cell migration GO:0010594 22 19 0,000 9,1E-03 0,01424074 ! fatty acid beta-oxidation GO:0006635 21 19 0,000 9,1E-03 0,01423464 ! peptide cross-linking GO:0018149 23 19 0,000 9,1E-03 0,01422854 ! ventricular cardiac muscle morphogenesis GO:0055010 21 19 0,000 9,1E-03 0,01422244 ! beta-catenin binding GO:0008013 23 19 0,000 9,1E-03 0,01421635 ! positive regulation of locomotion GO:0040017 21 19 0,000 9,1E-03 0,01421026 GO:0050921|positive regulation of chemotaxis, ! cell projection membrane GO:0031253 21 19 0,000 9,1E-03 0,01420418 ! positive regulation of inflammatory response GO:0050729 19 19 0,000 9,1E-03 0,01419811 ! trans-Golgi network transport vesicle GO:0030140 26 19 0,000 9,1E-03 0,01419204 ! sphingolipid biosynthetic process GO:0030148 20 19 0,000 9,1E-03 0,01418597 ! vitamin transport GO:0051180 21 19 0,000 9,1E-03 0,01417991 ! positive regulation of osteoblast differentiation GO:0045669 22 19 0,000 9,1E-03 0,01417386 ! terpenoid metabolic process GO:0006721 20 19 0,000 9,1E-03 0,01416781 ! leukotriene biosynthetic process GO:0019370 20 19 0,000 9,1E-03 0,01416176 GO:0043450|alkene biosynthetic process, ! nerve development GO:0021675 24 19 0,000 9,1E-03 0,01415573 ! retinoid binding GO:0005501 19 19 0,000 9,1E-03 0,01414969 GO:0019840|isoprenoid binding, ! regulation of amine transport GO:0051952 23 19 0,000 9,1E-03 0,01414366 ! inositol or phosphatidylinositol phosphatase activity GO:0004437 22 19 0,000 9,1E-03 0,01413764 ! histone deacetylase activity GO:0004407 20 19 0,000 9,1E-03 0,01413162 GO:0033558|protein deacetylase activity, ! gluconeogenesis GO:0006094 23 19 0,000 9,1E-03 0,01412561 ! post-Golgi vesicle-mediated transport GO:0006892 23 19 0,000 9,1E-03 0,0141196 ! microtubule-based transport GO:0010970 20 19 0,000 9,1E-03 0,0141136 ! superoxide metabolic process GO:0006801 21 19 0,000 9,1E-03 0,0141076 ! C21-steroid hormone metabolic process GO:0008207 20 19 0,000 9,1E-03 0,0141016 ! protein amino acid alkylation GO:0008213 22 19 0,000 9,1E-03 0,01409562 GO:0006479|protein amino acid methylation, ! L-ascorbic acid binding GO:0031418 19 19 0,000 9,1E-03 0,01408963 ! regulation of DNA recombination GO:0000018 38 19 0,000 9,1E-03 0,01408366 ! photoreceptor cell maintenance GO:0045494 23 19 0,000 9,1E-03 0,01407768 ! positive regulation of cytoskeleton organization GO:0051495 22 19 0,000 9,1E-03 0,01407171 ! acetylcholine binding GO:0042166 20 19 0,000 9,1E-03 0,01406575 ! heme metabolic process GO:0042168 20 19 0,000 9,1E-03 0,01405979 ! SH2 domain binding GO:0042169 25 19 0,000 9,1E-03 0,01405384 ! neurotransmitter:sodium symporter activity GO:0005328 21 19 0,000 9,1E-03 0,01404789 ! negative regulation of protein catabolic process GO:0042177 19 19 0,000 9,1E-03 0,01404195 ! carbohydrate kinase activity GO:0019200 20 19 0,000 9,1E-03 0,01403602 ! RNA methyltransferase activity GO:0008173 19 19 0,000 9,1E-03 0,01403008 ! RNA-dependent ATPase activity GO:0008186 29 19 0,000 9,1E-03 0,01402416 ! body fluid secretion GO:0007589 21 19 0,000 9,1E-03 0,01401823 ! neuropeptide hormone activity GO:0005184 25 19 0,000 9,1E-03 0,01401232 ! secretory granule membrane GO:0030667 21 19 0,000 9,1E-03 0,0140064 ! extracellular-glutamate-gated ion channel activity GO:0005234 23 19 0,000 9,1E-03 0,0140005 ! ribonucleoprotein binding GO:0043021 20 19 0,000 9,1E-03 0,01399459 ! peptidase activator activity GO:0016504 21 19 0,000 9,1E-03 0,0139887 ! transcription elongation regulator activity GO:0003711 20 19 0,000 9,1E-03 0,0139828 ! small conjugating protein-specific protease activity GO:0019783 21 19 0,000 9,1E-03 0,01397692 ! regulation of BMP signaling pathway GO:0030510 20 19 0,000 9,1E-03 0,01397103 ! sialyltransferase activity GO:0008373 31 19 0,000 9,1E-03 0,01396516 ! ATP-dependent DNA helicase activity GO:0004003 30 19 0,000 9,1E-03 0,01395928 ! chaperone binding GO:0051087 21 20 0,000 9,576E-03 0,01468467 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 23 20 0,000 9,576E-03 0,0146785 ! regulation of anti-apoptosis GO:0045767 20 20 0,000 9,576E-03 0,01467233 ! reciprocal meiotic recombination GO:0007131 40 20 0,000 9,576E-03 0,01466617 ! protein amino acid ADP-ribosylation GO:0006471 23 20 0,000 9,576E-03 0,01466002 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016796 30 20 0,000 9,576E-03 0,01465387 ! retina development in camera-type eye GO:0060041 24 20 0,000 9,576E-03 0,01464773 ! negative regulation of lipid metabolic process GO:0045833 34 20 0,000 9,576E-03 0,01464159 ! ovarian follicle development GO:0001541 21 20 0,000 9,576E-03 0,01463545 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 33 20 0,000 9,576E-03 0,01462933 ! proton-transporting two-sector ATPase complex, proton-transporting domain GO:0033177 21 20 0,000 9,576E-03 0,0146232 ! hydrogen peroxide metabolic process GO:0042743 20 20 0,000 9,576E-03 0,01461708 ! diencephalon development GO:0021536 22 20 0,000 9,576E-03 0,01461097 ! nuclear inner membrane GO:0005637 21 20 0,000 9,576E-03 0,01460486 ! regulation of lipid transport GO:0032368 22 20 0,000 9,576E-03 0,01459876 ! response to glucocorticoid stimulus GO:0051384 22 20 0,000 9,576E-03 0,01459266 ! glutathione metabolic process GO:0006749 21 20 0,000 9,576E-03 0,01458657 ! transcriptional repressor complex GO:0017053 23 20 0,000 9,576E-03 0,01458048 ! vitamin A metabolic process GO:0006776 20 20 0,000 9,576E-03 0,0145744 ! positive regulation of lymphocyte differentiation GO:0045621 30 20 0,000 9,576E-03 0,01456832 ! negative regulation of cytokine production GO:0001818 23 20 0,000 9,576E-03 0,01456225 ! phosphorus-oxygen lyase activity GO:0016849 21 20 0,000 9,576E-03 0,01455618 ! peptide hormone secretion GO:0030072 25 20 0,000 9,576E-03 0,01455012 GO:0002790|peptide secretion, ! actin filament-based movement GO:0030048 22 20 0,000 9,576E-03 0,01454406 ! Rab GTPase binding GO:0017137 22 20 0,000 9,576E-03 0,01453801 ! initiation of viral infection GO:0019059 22 20 0,000 9,576E-03 0,01453196 ! voltage-gated anion channel activity GO:0008308 23 20 0,000 9,576E-03 0,01452592 ! heterochromatin GO:0000792 20 20 0,000 9,576E-03 0,01451988 ! aminoglycan catabolic process GO:0006026 22 20 0,000 9,576E-03 0,01451385 ! glycosaminoglycan biosynthetic process GO:0006024 21 20 0,000 9,576E-03 0,01450782 ! regulation of chemotaxis GO:0050920 22 20 0,000 9,576E-03 0,0145018 ! calcium-independent cell-cell adhesion GO:0016338 27 20 0,000 9,576E-03 0,01449578 ! high-density lipoprotein particle GO:0034364 30 20 0,000 9,576E-03 0,01448977 ! visual behavior GO:0007632 34 20 0,000 9,576E-03 0,01448376 ! regulation of cell-matrix adhesion GO:0001952 26 20 0,000 9,576E-03 0,01447776 GO:0010810|regulation of cell-substrate adhesion, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 23 20 0,000 9,576E-03 0,01447176 ! immune response-activating cell surface receptor signaling pathway GO:0002429 27 20 0,000 9,576E-03 0,01446577 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of nitric oxide biosynthetic process GO:0045428 21 20 0,000 9,576E-03 0,01445978 ! vesicle docking during exocytosis GO:0006904 21 20 0,000 9,576E-03 0,0144538 ! cell structure disassembly during apoptosis GO:0006921 31 20 0,000 9,576E-03 0,01444782 ! nucleotide kinase activity GO:0019201 26 20 0,000 9,576E-03 0,01444185 ! rRNA binding GO:0019843 22 20 0,000 9,576E-03 0,01443588 ! cytolysis GO:0019835 22 20 0,000 9,576E-03 0,01442992 ! renal system process GO:0003014 22 20 0,000 9,576E-03 0,01442396 ! specific transcriptional repressor activity GO:0016566 23 20 0,000 9,576E-03 0,01441801 ! fatty acid transport GO:0015908 23 20 0,000 9,576E-03 0,01441206 ! transaminase activity GO:0008483 22 20 0,000 9,576E-03 0,01440611 ! activation of JUN kinase activity GO:0007257 22 20 0,000 9,576E-03 0,01440018 ! collagen catabolic process GO:0030574 21 20 0,000 9,576E-03 0,01439424 ! microvillus GO:0005902 25 20 0,000 9,576E-03 0,01438831 ! tumor necrosis factor receptor binding GO:0005164 22 20 0,000 9,576E-03 0,01438239 ! connexon complex GO:0005922 23 20 0,000 9,576E-03 0,01437647 ! positive regulation of DNA replication GO:0045740 27 21 0,000 0,01005311 0,01508586 ! positive regulation of protein catabolic process GO:0045732 23 21 0,000 0,01005311 0,01507966 ! translational initiation GO:0006413 21 21 0,000 0,01005311 0,01507346 ! NF-kappaB binding GO:0051059 31 21 0,000 0,01005311 0,01506727 ! heterotrimeric G-protein complex GO:0005834 23 21 0,000 0,01005311 0,01506108 ! positive regulation of bone remodeling GO:0046852 22 21 0,000 0,01005311 0,0150549 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 25 21 0,000 0,01005311 0,01504872 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! transition metal ion transmembrane transporter activity GO:0046915 25 21 0,000 0,01005311 0,01504255 ! glutathione transferase activity GO:0004364 21 21 0,000 0,01005311 0,01503638 ! voltage-gated calcium channel complex GO:0005891 28 21 0,000 0,01005311 0,01503022 ! glutamate signaling pathway GO:0007215 23 21 0,000 0,01005311 0,01502406 ! regeneration GO:0031099 24 21 0,000 0,01005311 0,01501791 ! apoptotic mitochondrial changes GO:0008637 33 21 0,000 0,01005311 0,01501176 ! MHC class I protein complex GO:0042612 31 21 0,000 0,01005311 0,01500562 ! cellular response to starvation GO:0009267 22 21 0,000 0,01005311 0,01499948 ! peroxisome organization GO:0007031 22 21 0,000 0,01005311 0,01499335 ! vacuole organization GO:0007033 23 21 0,000 0,01005311 0,01498722 ! apoptotic nuclear changes GO:0030262 24 21 0,000 0,01005311 0,0149811 ! response to lipopolysaccharide GO:0032496 31 21 0,000 0,01005311 0,01497498 ! neural crest cell development GO:0014032 24 21 0,000 0,01005311 0,01496887 GO:0014033|neural crest cell differentiation, ! regulation of protein binding GO:0043393 25 21 0,000 0,01005311 0,01496276 ! nucleobase metabolic process GO:0009112 23 21 0,000 0,01005311 0,01495666 ! regulation of steroid metabolic process GO:0019218 23 21 0,000 0,01005311 0,01495057 ! ribonucleoside monophosphate metabolic process GO:0009161 26 21 0,000 0,01005311 0,01494447 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! monocarboxylic acid transmembrane transporter activity GO:0008028 25 21 0,000 0,01005311 0,01493839 ! pallium development GO:0021543 22 21 0,000 0,01005311 0,0149323 ! synaptic vesicle transport GO:0048489 25 21 0,000 0,01005311 0,01492623 ! negative regulation of Wnt receptor signaling pathway GO:0030178 22 21 0,000 0,01005311 0,01492015 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 21 21 0,000 0,01005311 0,01491409 ! negative regulation of neuron differentiation GO:0045665 22 21 0,000 0,01005311 0,01490802 ! cyclase activity GO:0009975 22 21 0,000 0,01005311 0,01490197 ! aspartate family amino acid metabolic process GO:0009066 24 21 0,000 0,01005311 0,01489591 ! gut development GO:0048565 23 21 0,000 0,01005311 0,01488986 ! calcium-dependent phospholipid binding GO:0005544 22 21 0,000 0,01005311 0,01488382 ! negative regulation of T cell activation GO:0050868 23 21 0,000 0,01005311 0,01487778 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,01005311 0,01487175 ! cortical actin cytoskeleton GO:0030864 21 21 0,000 0,01005311 0,01486572 ! cellular aldehyde metabolic process GO:0006081 22 21 0,000 0,01005311 0,0148597 ! membrane lipid biosynthetic process GO:0046467 22 21 0,000 0,01005311 0,01485368 ! axis specification GO:0009798 25 21 0,000 0,01005311 0,01484767 ! response to alkaloid GO:0043279 27 21 0,000 0,01005311 0,01484166 ! 4 iron, 4 sulfur cluster binding GO:0051539 24 21 0,000 0,01005311 0,01483565 ! response to ethanol GO:0045471 28 21 0,000 0,01005311 0,01482965 ! response to carbohydrate stimulus GO:0009743 24 21 0,000 0,01005311 0,01482366 ! smooth muscle contraction GO:0006939 25 21 0,000 0,01005311 0,01481767 ! ubiquitin binding GO:0043130 25 21 0,000 0,01005311 0,01481169 ! vesicle targeting GO:0006903 22 21 0,000 0,01005311 0,01480571 ! phospholipase A2 activity GO:0004623 32 21 0,000 0,01005311 0,01479973 ! SNARE binding GO:0000149 24 21 0,000 0,01005311 0,01479376 ! interaction with host GO:0051701 26 21 0,000 0,01005311 0,0147878 ! positive regulation of myeloid leukocyte differentiation GO:0002763 26 21 0,000 0,01005311 0,01478184 ! lymphocyte proliferation GO:0046651 24 21 0,000 0,01005311 0,01477588 ! regulation of tumor necrosis factor production GO:0032680 24 21 0,000 0,01005311 0,01476993 ! regulation of interleukin-2 production GO:0032663 21 21 0,000 0,01005311 0,01476398 ! negative regulation of angiogenesis GO:0016525 23 21 0,000 0,01005311 0,01475804 ! cell-cell junction organization GO:0045216 24 21 0,000 0,01005311 0,01475211 ! single-stranded RNA binding GO:0003727 22 21 0,000 0,01005311 0,01474617 ! cyclic nucleotide binding GO:0030551 25 21 0,000 0,01005311 0,01474025 ! caveola GO:0005901 25 21 0,000 0,01005311 0,01473433 ! water-soluble vitamin biosynthetic process GO:0042364 23 21 0,000 0,01005311 0,01472841 ! insulin receptor binding GO:0005158 25 21 0,000 0,01005311 0,0147225 ! pyrimidine nucleotide biosynthetic process GO:0006221 26 21 0,000 0,01005311 0,01471659 ! regulation of multi-organism process GO:0043900 32 21 0,000 0,01005311 0,01471068 ! mRNA export from nucleus GO:0006406 26 22 0,000 0,01052958 0,01540172 ! metencephalon development GO:0022037 25 22 0,000 0,01052958 0,01539555 ! regulation of interferon-gamma production GO:0032649 25 22 0,000 0,01052958 0,01538938 ! hormone secretion GO:0046879 28 22 0,000 0,01052958 0,01538322 ! vesicle docking GO:0048278 24 22 0,000 0,01052958 0,01537706 ! muscle myosin complex GO:0005859 23 22 0,000 0,01052958 0,01537091 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 24 22 0,000 0,01052958 0,01536476 ! actomyosin structure organization GO:0031032 24 22 0,000 0,01052958 0,01535862 ! microtubule organizing center organization GO:0031023 33 22 0,000 0,01052958 0,01535248 GO:0051297|centrosome organization, ! positive regulation of innate immune response GO:0045089 23 22 0,000 0,01052958 0,01534634 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 33 22 0,000 0,01052958 0,01534022 ! sperm motility GO:0030317 23 22 0,000 0,01052958 0,01533409 ! potassium channel regulator activity GO:0015459 29 22 0,000 0,01052958 0,01532797 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 24 22 0,000 0,01052958 0,01532186 ! vacuolar transport GO:0007034 22 22 0,000 0,01052958 0,01531575 ! oxidoreductase activity, acting on heme group of donors GO:0016675 23 22 0,000 0,01052958 0,01530965 GO:0016676|oxidoreductase activity, acting on heme group of donors, oxygen as acceptor, GO:0004129|cytochrome-c oxidase activity, GO:0015002|heme-copper terminal oxidase activity, ! central nervous system neuron differentiation GO:0021953 24 22 0,000 0,01052958 0,01530355 ! cellular response to reactive oxygen species GO:0034614 26 22 0,000 0,01052958 0,01529745 ! purine ribonucleoside metabolic process GO:0046128 24 22 0,000 0,01052958 0,01529136 GO:0042278|purine nucleoside metabolic process, ! G-protein chemoattractant receptor activity GO:0001637 24 22 0,000 0,01052958 0,01528528 GO:0004950|chemokine receptor activity, ! response to corticosteroid stimulus GO:0031960 25 22 0,000 0,01052958 0,0152792 ! PML body GO:0016605 25 22 0,000 0,01052958 0,01527312 ! barbed-end actin filament capping GO:0051016 24 22 0,000 0,01052958 0,01526705 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 27 22 0,000 0,01052958 0,01526099 ! regulation of foam cell differentiation GO:0010743 28 22 0,000 0,01052958 0,01525492 ! cyclic nucleotide biosynthetic process GO:0009190 23 22 0,000 0,01052958 0,01524887 ! leukotriene metabolic process GO:0006691 23 22 0,000 0,01052958 0,01524282 ! glycosphingolipid metabolic process GO:0006687 23 22 0,000 0,01052958 0,01523677 ! deacetylase activity GO:0019213 23 22 0,000 0,01052958 0,01523073 ! pentose metabolic process GO:0019321 23 22 0,000 0,01052958 0,01522469 ! collagen fibril organization GO:0030199 32 22 0,000 0,01052958 0,01521866 ! regulation of response to biotic stimulus GO:0002831 33 22 0,000 0,01052958 0,01521263 ! positive regulation of adaptive immune response GO:0002821 22 22 0,000 0,01052958 0,01520661 ! peptidyl-serine modification GO:0018209 30 22 0,000 0,01052958 0,01520059 ! DNA-directed RNA polymerase complex GO:0000428 23 22 0,000 0,01052958 0,01519458 GO:0055029|nuclear DNA-directed RNA polymerase complex, ! endoribonuclease activity, producing 5'-phosphomonoesters GO:0016891 32 22 0,000 0,01052958 0,01518857 ! positive regulation of behavior GO:0048520 24 22 0,000 0,01052958 0,01518257 ! regulation of generation of precursor metabolites and energy GO:0043467 25 22 0,000 0,01052958 0,01517657 ! aromatic compound catabolic process GO:0019439 23 22 0,000 0,01052958 0,01517058 ! embryonic epithelial tube formation GO:0001838 25 22 0,000 0,01052958 0,01516459 GO:0001841|neural tube formation, ! telomere organization GO:0032200 43 22 0,000 0,01052958 0,0151586 GO:0000723|telomere maintenance, ! acetyl-CoA catabolic process GO:0046356 24 22 0,000 0,01052958 0,01515262 GO:0006099|tricarboxylic acid cycle, ! protein tetramerization GO:0051262 25 22 0,000 0,01052958 0,01514665 ! DNA catabolic process, endonucleolytic GO:0000737 24 22 0,000 0,01052958 0,01514068 ! glycerol metabolic process GO:0006071 24 22 0,000 0,01052958 0,01513471 ! cellular component assembly involved in morphogenesis GO:0010927 23 22 0,000 0,01052958 0,01512875 ! nuclear chromatin GO:0000790 23 22 0,000 0,01052958 0,0151228 ! cellular iron ion homeostasis GO:0006879 25 22 0,000 0,01052958 0,01511684 ! aminoglycan biosynthetic process GO:0006023 23 22 0,000 0,01052958 0,0151109 ! positive regulation of JAK-STAT cascade GO:0046427 25 22 0,000 0,01052958 0,01510496 ! sterol binding GO:0032934 24 22 0,000 0,01052958 0,01509902 ! calcium-dependent cell-cell adhesion GO:0016339 23 22 0,000 0,01052958 0,01509308 ! digestive system process GO:0022600 25 22 0,000 0,01052958 0,01508716 ! neurotransmitter transporter activity GO:0005326 24 22 0,000 0,01052958 0,01508123 ! organic acid:sodium symporter activity GO:0005343 25 22 0,000 0,01052958 0,01507531 ! nonmotile primary cilium GO:0031513 24 22 0,000 0,01052958 0,0150694 ! negative regulation of myeloid leukocyte differentiation GO:0002762 26 22 0,000 0,01052958 0,01506349 ! base-excision repair GO:0006284 33 22 0,000 0,01052958 0,01505759 ! regulation of chromosome organization GO:0033044 27 22 0,000 0,01052958 0,01505169 ! DNA modification GO:0006304 25 22 0,000 0,01052958 0,01504579 ! detection of chemical stimulus GO:0009593 23 22 0,000 0,01052958 0,0150399 ! positive regulation of tissue remodeling GO:0034105 23 22 0,000 0,01052958 0,01503401 ! GABA-A receptor activity GO:0004890 27 22 0,000 0,01052958 0,01502813 ! response to cytokine stimulus GO:0034097 25 22 0,000 0,01052958 0,01502225 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0033764 24 22 0,000 0,01052958 0,01501638 ! pyrimidine nucleoside metabolic process GO:0006213 27 22 0,000 0,01052958 0,01501051 ! phosphoprotein phosphatase inhibitor activity GO:0004864 25 22 0,000 0,01052958 0,01500465 ! solute:cation antiporter activity GO:0015298 23 22 0,000 0,01052958 0,01499879 ! regulation of transmembrane transport GO:0034762 28 23 0,000 0,01100584 0,01567109 ! protein amino acid O-linked glycosylation GO:0006493 28 23 0,000 0,01100584 0,01566497 ! leukocyte adhesion GO:0007159 26 23 0,000 0,01100584 0,01565886 ! dicarboxylic acid metabolic process GO:0043648 27 23 0,000 0,01100584 0,01565276 ! odontogenesis of dentine-containing tooth GO:0042475 26 23 0,000 0,01100584 0,01564666 ! positive regulation of endocytosis GO:0045807 25 23 0,000 0,01100584 0,01564056 ! mitochondrial membrane organization GO:0007006 25 23 0,000 0,01100584 0,01563447 ! ureteric bud development GO:0001657 24 23 0,000 0,01100584 0,01562839 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 27 23 0,000 0,01100584 0,0156223 ! regulation of insulin secretion GO:0050796 27 23 0,000 0,01100584 0,01561623 ! vitamin biosynthetic process GO:0009110 25 23 0,000 0,01100584 0,01561016 ! negative regulation of neurogenesis GO:0050768 29 23 0,000 0,01100584 0,01560409 ! cholesterol biosynthetic process GO:0006695 29 23 0,000 0,01100584 0,01559803 ! deaminase activity GO:0019239 24 23 0,000 0,01100584 0,01559197 ! sensory perception of pain GO:0019233 26 23 0,000 0,01100584 0,01558592 ! lipid kinase activity GO:0001727 26 23 0,000 0,01100584 0,01557987 ! platelet activation GO:0030168 27 23 0,000 0,01100584 0,01557383 ! proteoglycan biosynthetic process GO:0030166 24 23 0,000 0,01100584 0,01556779 ! positive regulation of intracellular transport GO:0032388 26 23 0,000 0,01100584 0,01556175 ! regulation of blood coagulation GO:0030193 26 23 0,000 0,01100584 0,01555572 ! regulation of cytokine secretion GO:0050707 27 23 0,000 0,01100584 0,0155497 ! fat-soluble vitamin metabolic process GO:0006775 23 23 0,000 0,01100584 0,01554368 ! cellular alkene metabolic process GO:0043449 24 23 0,000 0,01100584 0,01553766 ! aromatic amino acid family metabolic process GO:0009072 25 23 0,000 0,01100584 0,01553165 ! cell surface binding GO:0043498 28 23 0,000 0,01100584 0,01552565 ! porphyrin metabolic process GO:0006778 24 23 0,000 0,01100584 0,01551965 GO:0033013|tetrapyrrole metabolic process, ! ligase activity, forming carbon-sulfur bonds GO:0016877 24 23 0,000 0,01100584 0,01551365 ! regulation of glucose import GO:0046324 28 23 0,000 0,01100584 0,01550766 ! insulin-like growth factor binding GO:0005520 27 23 0,000 0,01100584 0,01550167 ! alditol metabolic process GO:0019400 25 23 0,000 0,01100584 0,01549569 ! positive regulation of JUN kinase activity GO:0043507 25 23 0,000 0,01100584 0,01548971 ! pyruvate metabolic process GO:0006090 27 23 0,000 0,01100584 0,01548373 ! zinc ion transport GO:0006829 26 23 0,000 0,01100584 0,01547776 ! N-acetylglucosamine metabolic process GO:0006044 26 23 0,000 0,01100584 0,0154718 ! antigen processing and presentation of peptide antigen GO:0048002 30 23 0,000 0,01100584 0,01546584 ! sex determination GO:0007530 25 23 0,000 0,01100584 0,01545989 ! phosphate binding GO:0042301 25 23 0,000 0,01100584 0,01545393 ! positive regulation of leukocyte mediated immunity GO:0002705 24 23 0,000 0,01100584 0,01544799 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of interleukin-6 production GO:0032675 26 23 0,000 0,01100584 0,01544205 ! nuclear-transcribed mRNA catabolic process GO:0000956 26 23 0,000 0,01100584 0,01543611 ! 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 28 23 0,000 0,01100584 0,01543018 ! ubiquitin protein ligase binding GO:0031625 24 23 0,000 0,01100584 0,01542425 ! positive regulation of nuclear division GO:0051785 35 23 0,000 0,01100584 0,01541833 GO:0045840|positive regulation of mitosis, ! synaptogenesis GO:0007416 25 23 0,000 0,01100584 0,01541241 ! regulation of bone mineralization GO:0030500 23 23 0,000 0,01100584 0,01540649 ! neurotransmitter secretion GO:0007269 26 23 0,000 0,01100584 0,01540058 ! ethanolamine and derivative metabolic process GO:0042439 34 23 0,000 0,01100584 0,01539468 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 25 23 0,000 0,01100584 0,01538878 ! leukocyte proliferation GO:0070661 26 23 0,000 0,01100584 0,01538288 GO:0032943|mononuclear cell proliferation, ! myosin II complex GO:0016460 24 23 0,000 0,01100584 0,01537699 ! growth cone GO:0030426 27 24 0,000 0,01148191 0,01603599 ! oligosaccharide metabolic process GO:0009311 29 24 0,000 0,01148191 0,01602985 ! actin filament GO:0005884 26 24 0,000 0,01148191 0,01602372 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0016706 24 24 0,000 0,01148191 0,01601759 ! pancreas development GO:0031016 27 24 0,000 0,01148191 0,01601147 ! androgen receptor binding GO:0050681 34 24 0,000 0,01148191 0,01600535 ! calcium channel complex GO:0034704 31 24 0,000 0,01148191 0,01599924 ! coenzyme catabolic process GO:0009109 26 24 0,000 0,01148191 0,01599313 ! negative regulation of cell development GO:0010721 30 24 0,000 0,01148191 0,01598702 ! cardiac muscle tissue morphogenesis GO:0055008 27 24 0,000 0,01148191 0,01598092 GO:0060415|muscle tissue morphogenesis, ! phosphatase inhibitor activity GO:0019212 27 24 0,000 0,01148191 0,01597483 ! regulation of ARF GTPase activity GO:0032312 28 24 0,000 0,01148191 0,01596874 ! regulation of oxidoreductase activity GO:0051341 24 24 0,000 0,01148191 0,01596265 ! RNA splicing factor activity, transesterification mechanism GO:0031202 25 24 0,000 0,01148191 0,01595657 ! Rho GTPase binding GO:0017048 36 24 0,000 0,01148191 0,01595049 ! regulation of glucose transport GO:0010827 29 24 0,000 0,01148191 0,01594442 ! serine family amino acid metabolic process GO:0009069 27 24 0,000 0,01148191 0,01593836 ! intramolecular transferase activity GO:0016866 26 24 0,000 0,01148191 0,01593229 ! phosphoinositide phospholipase C activity GO:0004435 28 24 0,000 0,01148191 0,01592624 GO:0004434|inositol or phosphatidylinositol phosphodiesterase activity, ! Z disc GO:0030018 27 24 0,000 0,01148191 0,01592018 ! protein stabilization GO:0050821 24 24 0,000 0,01148191 0,01591413 ! protein import into nucleus, translocation GO:0000060 27 24 0,000 0,01148191 0,01590809 ! embryonic pattern specification GO:0009880 29 24 0,000 0,01148191 0,01590205 ! negative regulation of actin filament depolymerization GO:0030835 26 24 0,000 0,01148191 0,01589601 ! RNA polymerase complex GO:0030880 25 24 0,000 0,01148191 0,01588998 ! cellular polysaccharide biosynthetic process GO:0033692 24 24 0,000 0,01148191 0,01588396 ! glucosamine metabolic process GO:0006041 27 24 0,000 0,01148191 0,01587794 ! small conjugating protein binding GO:0032182 29 24 0,000 0,01148191 0,01587192 ! regulation of transcription factor import into nucleus GO:0042990 26 24 0,000 0,01148191 0,01586591 ! chemokine binding GO:0019956 26 24 0,000 0,01148191 0,0158599 ! catechol metabolic process GO:0009712 29 24 0,000 0,01148191 0,0158539 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! regulation of smooth muscle contraction GO:0006940 28 24 0,000 0,01148191 0,0158479 ! NAD+ ADP-ribosyltransferase activity GO:0003950 26 24 0,000 0,01148191 0,01584191 ! multicellular organismal response to stress GO:0033555 27 24 0,000 0,01148191 0,01583592 ! cell aging GO:0007569 47 24 0,000 0,01148191 0,01582993 ! immune response-activating signal transduction GO:0002757 31 24 0,000 0,01148191 0,01582395 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 26 24 0,000 0,01148191 0,01581798 ! fibroblast growth factor receptor signaling pathway GO:0008543 27 24 0,000 0,01148191 0,015812 ! voltage-gated calcium channel activity GO:0005245 31 24 0,000 0,01148191 0,01580604 ! cyclic-nucleotide phosphodiesterase activity GO:0004112 29 24 0,000 0,01148191 0,01580008 ! metallocarboxypeptidase activity GO:0004181 24 24 0,000 0,01148191 0,01579412 ! caspase regulator activity GO:0043028 26 24 0,000 0,01148191 0,01578816 ! 3'-5' exonuclease activity GO:0008408 43 24 0,000 0,01148191 0,01578222 ! small nuclear ribonucleoprotein complex GO:0030532 24 24 0,000 0,01148191 0,01577627 ! selenium binding GO:0008430 24 24 0,000 0,01148191 0,01577033 ! spindle pole GO:0000922 35 24 0,000 0,01148191 0,0157644 ! Rho GTPase activator activity GO:0005100 28 24 0,000 0,01148191 0,01575846 ! site of polarized growth GO:0030427 28 25 0,000 0,01195777 0,01640539 ! phenol metabolic process GO:0018958 31 25 0,000 0,01195777 0,01639922 ! regulation of lipid biosynthetic process GO:0046890 35 25 0,000 0,01195777 0,01639306 ! protein amino acid acylation GO:0043543 28 25 0,000 0,01195777 0,0163869 ! aromatase activity GO:0070330 28 25 0,000 0,01195777 0,01638075 ! cholesterol homeostasis GO:0042632 27 25 0,000 0,01195777 0,0163746 GO:0055092|sterol homeostasis, ! positive regulation of epithelial cell proliferation GO:0050679 29 25 0,000 0,01195777 0,01636846 ! oxidoreductase activity, acting on the CH-NH group of donors GO:0016645 29 25 0,000 0,01195777 0,01636232 ! response to starvation GO:0042594 26 25 0,000 0,01195777 0,01635618 ! dynein complex GO:0030286 28 25 0,000 0,01195777 0,01635005 ! ARF GTPase activator activity GO:0008060 29 25 0,000 0,01195777 0,01634392 ! regulation of behavior GO:0050795 27 25 0,000 0,01195777 0,0163378 ! regulation of biomineral formation GO:0070167 25 25 0,000 0,01195777 0,01633169 ! hexose biosynthetic process GO:0019319 31 25 0,000 0,01195777 0,01632557 ! group transfer coenzyme metabolic process GO:0006752 25 25 0,000 0,01195777 0,01631947 ! hormone transport GO:0009914 31 25 0,000 0,01195777 0,01631336 ! response to molecule of bacterial origin GO:0002237 35 25 0,000 0,01195777 0,01630726 ! cell adhesion molecule binding GO:0050839 29 25 0,000 0,01195777 0,01630117 ! regulation of coagulation GO:0050818 28 25 0,000 0,01195777 0,01629508 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,01195777 0,016289 ! myeloid leukocyte differentiation GO:0002573 28 25 0,000 0,01195777 0,01628292 ! acetyl-CoA metabolic process GO:0006084 27 25 0,000 0,01195777 0,01627684 ! chromosome, telomeric region GO:0000781 38 25 0,000 0,01195777 0,01627077 ! molting cycle process GO:0022404 28 25 0,000 0,01195777 0,0162647 GO:0022405|hair cycle process, GO:0001942|hair follicle development, ! collagen metabolic process GO:0032963 26 25 0,000 0,01195777 0,01625864 ! xenobiotic metabolic process GO:0006805 27 25 0,000 0,01195777 0,01625258 ! phototransduction GO:0007602 27 25 0,000 0,01195777 0,01624653 ! negative regulation of response to external stimulus GO:0032102 30 25 0,000 0,01195777 0,01624048 ! regulation of endothelial cell proliferation GO:0001936 29 25 0,000 0,01195777 0,01623444 ! protein phosphatase binding GO:0019903 27 25 0,000 0,01195777 0,0162284 ! negative regulation of DNA replication GO:0008156 31 25 0,000 0,01195777 0,01622236 ! multicellular organismal catabolic process GO:0044243 27 25 0,000 0,01195777 0,01621633 ! autophagy GO:0006914 28 25 0,000 0,01195777 0,01621031 ! steroid dehydrogenase activity GO:0016229 27 25 0,000 0,01195777 0,01620428 ! response to ionizing radiation GO:0010212 37 25 0,000 0,01195777 0,01619827 ! DNA-directed DNA polymerase activity GO:0003887 30 25 0,000 0,01195777 0,01619225 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 31 26 0,000 0,01243342 0,0168301 ! positive regulation of cell adhesion GO:0045785 34 26 0,000 0,01243342 0,01682386 ! epidermal growth factor receptor signaling pathway GO:0007173 32 26 0,000 0,01243342 0,01681762 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 29 26 0,000 0,01243342 0,01681139 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen GO:0016709 28 26 0,000 0,01243342 0,01680516 ! positive regulation of lipid metabolic process GO:0045834 27 26 0,000 0,01243342 0,01679894 ! hair cycle GO:0042633 29 26 0,000 0,01243342 0,01679272 GO:0042303|molting cycle, ! thyroid hormone receptor binding GO:0046966 30 26 0,000 0,01243342 0,0167865 ! polysaccharide catabolic process GO:0000272 39 26 0,000 0,01243342 0,01678029 ! peptidyl-tyrosine phosphorylation GO:0018108 30 26 0,000 0,01243342 0,01677408 ! early endosome membrane GO:0031901 31 26 0,000 0,01243342 0,01676788 ! negative regulation of protein kinase cascade GO:0010741 40 26 0,000 0,01243342 0,01676169 ! iron ion homeostasis GO:0055072 29 26 0,000 0,01243342 0,01675549 ! glycolipid metabolic process GO:0006664 36 26 0,000 0,01243342 0,01674931 ! GABA receptor activity GO:0016917 31 26 0,000 0,01243342 0,01674312 ! PDZ domain binding GO:0030165 28 26 0,000 0,01243342 0,01673695 ! positive regulation of protein secretion GO:0050714 29 26 0,000 0,01243342 0,01673077 ! regulation of cellular carbohydrate metabolic process GO:0010675 29 26 0,000 0,01243342 0,0167246 ! AP-type membrane coat adaptor complex GO:0030119 30 26 0,000 0,01243342 0,01671844 GO:0030131|clathrin adaptor complex, ! neuromuscular process controlling balance GO:0050885 32 26 0,000 0,01243342 0,01671228 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016893 45 26 0,000 0,01243342 0,01670612 ! fatty acid binding GO:0005504 28 26 0,000 0,01243342 0,01669997 ! blastocyst development GO:0001824 27 26 0,000 0,01243342 0,01669383 ! regulation of JUN kinase activity GO:0043506 28 26 0,000 0,01243342 0,01668768 ! lysine N-acetyltransferase activity GO:0004468 29 26 0,000 0,01243342 0,01668155 GO:0004402|histone acetyltransferase activity, ! negative regulation of protein polymerization GO:0032272 37 26 0,000 0,01243342 0,01667541 ! regulation of smooth muscle cell proliferation GO:0048660 30 26 0,000 0,01243342 0,01666929 ! regulation of actin filament depolymerization GO:0030834 28 26 0,000 0,01243342 0,01666316 ! positive regulation of cell projection organization GO:0031346 27 26 0,000 0,01243342 0,01665704 ! iron ion transport GO:0006826 33 26 0,000 0,01243342 0,01665093 ! regulation of synaptic plasticity GO:0048167 36 26 0,000 0,01243342 0,01664482 ! glucose transport GO:0015758 27 26 0,000 0,01243342 0,01663871 ! insulin receptor signaling pathway GO:0008286 34 26 0,000 0,01243342 0,01663261 ! spinal cord development GO:0021510 30 26 0,000 0,01243342 0,01662651 ! histone deacetylase complex GO:0000118 29 26 0,000 0,01243342 0,01662042 ! regulation of peptide secretion GO:0002791 30 26 0,000 0,01243342 0,01661433 ! regulation of production of molecular mediator of immune response GO:0002700 27 26 0,000 0,01243342 0,01660825 ! RNA helicase activity GO:0003724 46 26 0,000 0,01243342 0,01660217 ! brush border GO:0005903 30 26 0,000 0,01243342 0,01659609 ! gap junction GO:0005921 29 26 0,000 0,01243342 0,01659002 ! anion:cation symporter activity GO:0015296 29 26 0,000 0,01243342 0,01658396 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 39 27 0,000 0,01290887 0,01721183 ! RNA export from nucleus GO:0006405 31 27 0,000 0,01290887 0,01720554 ! mRNA catabolic process GO:0006402 31 27 0,000 0,01290887 0,01719926 ! myelination GO:0042552 31 27 0,000 0,01290887 0,01719298 ! trans-Golgi network GO:0005802 31 27 0,000 0,01290887 0,01718671 ! transferase activity, transferring nitrogenous groups GO:0016769 29 27 0,000 0,01290887 0,01718044 ! spliceosomal snRNP biogenesis GO:0000387 29 27 0,000 0,01290887 0,01717417 ! solute:solute antiporter activity GO:0015300 28 27 0,000 0,01290887 0,01716791 ! vasculogenesis GO:0001570 32 27 0,000 0,01290887 0,01716165 ! hexose transport GO:0008645 28 27 0,000 0,01290887 0,0171554 GO:0015749|monosaccharide transport, ! regulation of innate immune response GO:0045088 28 27 0,000 0,01290887 0,01714915 ! spindle organization GO:0007051 38 27 0,000 0,01290887 0,01714291 ! cellular response to oxidative stress GO:0034599 32 27 0,000 0,01290887 0,01713667 ! response to organic cyclic substance GO:0014070 34 27 0,000 0,01290887 0,01713044 ! cell fate determination GO:0001709 29 27 0,000 0,01290887 0,01712421 ! lipid oxidation GO:0034440 29 27 0,000 0,01290887 0,01711798 GO:0019395|fatty acid oxidation, ! fatty acid catabolic process GO:0009062 31 27 0,000 0,01290887 0,01711176 ! collagen binding GO:0005518 29 27 0,000 0,01290887 0,01710555 ! carboxy-lyase activity GO:0016831 27 27 0,000 0,01290887 0,01709934 ! phospholipid transporter activity GO:0005548 30 27 0,000 0,01290887 0,01709313 ! liver development GO:0001889 33 27 0,000 0,01290887 0,01708693 ! mitotic sister chromatid segregation GO:0000070 46 27 0,000 0,01290887 0,01708073 ! determination of bilateral symmetry GO:0009855 32 27 0,000 0,01290887 0,01707454 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! integrin complex GO:0008305 30 27 0,000 0,01290887 0,01706835 ! membrane docking GO:0022406 29 27 0,000 0,01290887 0,01706216 ! detection of light stimulus involved in sensory perception GO:0050962 29 27 0,000 0,01290887 0,01705598 GO:0050908|detection of light stimulus involved in visual perception, ! multicellular organismal macromolecule metabolic process GO:0044259 28 27 0,000 0,01290887 0,01704981 ! respiratory gaseous exchange GO:0007585 30 27 0,000 0,01290887 0,01704364 ! phospholipid transport GO:0015914 29 27 0,000 0,01290887 0,01703747 ! sarcoplasmic reticulum GO:0016529 29 27 0,000 0,01290887 0,01703131 ! aminopeptidase activity GO:0004177 33 27 0,000 0,01290887 0,01702515 ! cellular response to nutrient levels GO:0031669 28 27 0,000 0,01290887 0,017019 ! RNA polymerase II transcription factor activity, enhancer binding GO:0003705 33 27 0,000 0,01290887 0,01701285 ! biogenic amine biosynthetic process GO:0042401 29 27 0,000 0,01290887 0,01700671 ! negative regulation of transcription regulator activity GO:0090048 32 27 0,000 0,01290887 0,01700057 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of immune effector process GO:0002699 29 27 0,000 0,01290887 0,01699443 ! ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 31 28 0,000 0,01338412 0,01761374 ! Golgi stack GO:0005795 30 28 0,000 0,01338412 0,01760739 ! male gonad development GO:0008584 32 28 0,000 0,01338412 0,01760104 ! regulation of fatty acid metabolic process GO:0019217 41 28 0,000 0,01338412 0,0175947 ! lipoprotein binding GO:0008034 31 28 0,000 0,01338412 0,01758836 ! mesoderm formation GO:0001707 34 28 0,000 0,01338412 0,01758202 ! negative regulation of MAP kinase activity GO:0043407 30 28 0,000 0,01338412 0,01757569 ! peptidyl-tyrosine modification GO:0018212 32 28 0,000 0,01338412 0,01756937 ! deoxyribonuclease activity GO:0004536 56 28 0,000 0,01338412 0,01756305 ! nicotinamide metabolic process GO:0006769 32 28 0,000 0,01338412 0,01755673 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 31 28 0,000 0,01338412 0,01755042 ! regulation of osteoblast differentiation GO:0045667 33 28 0,000 0,01338412 0,01754412 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0016814 30 28 0,000 0,01338412 0,01753782 ! negative regulation of neuron apoptosis GO:0043524 39 28 0,000 0,01338412 0,01753152 ! tissue homeostasis GO:0001894 31 28 0,000 0,01338412 0,01752523 GO:0048871|multicellular organismal homeostasis, ! DNA damage checkpoint GO:0000077 48 28 0,000 0,01338412 0,01751894 ! negative regulation of protein complex assembly GO:0031333 39 28 0,000 0,01338412 0,01751265 ! regulation of carbohydrate metabolic process GO:0006109 31 28 0,000 0,01338412 0,01750638 ! sister chromatid segregation GO:0000819 49 28 0,000 0,01338412 0,0175001 ! post-embryonic development GO:0009791 32 28 0,000 0,01338412 0,01749383 ! complement activation, classical pathway GO:0006958 33 28 0,000 0,01338412 0,01748756 ! detection of visible light GO:0009584 30 28 0,000 0,01338412 0,0174813 ! calcium-mediated signaling GO:0019722 30 28 0,000 0,01338412 0,01747505 ! receptor regulator activity GO:0030545 31 28 0,000 0,01338412 0,01746879 ! acetylgalactosaminyltransferase activity GO:0008376 33 28 0,000 0,01338412 0,01746255 ! symbiosis, encompassing mutualism through parasitism GO:0044403 33 28 0,000 0,01338412 0,0174563 ! response to heat GO:0009408 33 28 0,000 0,01338412 0,01745006 ! response to xenobiotic stimulus GO:0009410 31 28 0,000 0,01338412 0,01744383 ! response to hydrogen peroxide GO:0042542 32 29 0,000 0,01385917 0,01805652 ! hormone binding GO:0042562 31 29 0,000 0,01385917 0,01805007 ! establishment or maintenance of cell polarity GO:0007163 34 29 0,000 0,01385917 0,01804363 ! striated muscle cell differentiation GO:0051146 42 29 0,000 0,01385917 0,01803719 ! NADP or NADPH binding GO:0050661 33 29 0,000 0,01385917 0,01803076 ! nucleotide receptor activity, G-protein coupled GO:0001608 31 29 0,000 0,01385917 0,01802433 GO:0045028|purinergic nucleotide receptor activity, G-protein coupled, ! mitochondrial intermembrane space GO:0005758 41 29 0,000 0,01385917 0,01801791 ! erythrocyte differentiation GO:0030218 35 29 0,000 0,01385917 0,01801149 ! ceramide metabolic process GO:0006672 29 29 0,000 0,01385917 0,01800507 ! camera-type eye morphogenesis GO:0048593 36 29 0,000 0,01385917 0,01799866 ! monosaccharide biosynthetic process GO:0046364 35 29 0,000 0,01385917 0,01799226 ! negative regulation of lymphocyte activation GO:0051250 32 29 0,000 0,01385917 0,01798586 ! alkaloid metabolic process GO:0009820 33 29 0,000 0,01385917 0,01797946 ! icosanoid biosynthetic process GO:0046456 30 29 0,000 0,01385917 0,01797307 ! regulation of pH GO:0006885 30 29 0,000 0,01385917 0,01796668 ! amino sugar metabolic process GO:0006040 41 29 0,000 0,01385917 0,0179603 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 34 29 0,000 0,01385917 0,01795392 ! phospholipase C activity GO:0004629 43 29 0,000 0,01385917 0,01794755 ! response to mechanical stimulus GO:0009612 33 29 0,000 0,01385917 0,01794118 ! clathrin coated vesicle membrane GO:0030665 33 29 0,000 0,01385917 0,01793482 ! sodium channel activity GO:0005272 33 29 0,000 0,01385917 0,01792846 ! sarcoplasm GO:0016528 31 29 0,000 0,01385917 0,0179221 ! detection of light stimulus GO:0009583 31 29 0,000 0,01385917 0,01791575 ! spermatid development GO:0007286 30 29 0,000 0,01385917 0,0179094 ! DNA polymerase activity GO:0034061 34 29 0,000 0,01385917 0,01790306 ! peptidyl-prolyl cis-trans isomerase activity GO:0003755 31 29 0,000 0,01385917 0,01789672 ! sarcolemma GO:0042383 30 29 0,000 0,01385917 0,01789039 ! tumor necrosis factor receptor superfamily binding GO:0032813 31 29 0,000 0,01385917 0,01788406 ! galactosyltransferase activity GO:0008378 33 29 0,000 0,01385917 0,01787774 ! establishment of vesicle localization GO:0051650 30 29 0,000 0,01385917 0,01787142 ! transforming growth factor beta receptor signaling pathway GO:0007179 34 30 0,000 0,01433401 0,0184772 ! mitochondrial nucleoid GO:0042645 44 30 0,000 0,01433401 0,01847067 GO:0009295|nucleoid, ! cholesterol transport GO:0030301 33 30 0,000 0,01433401 0,01846415 GO:0015918|sterol transport, ! histone-lysine N-methyltransferase activity GO:0018024 34 30 0,000 0,01433401 0,01845763 GO:0016278|lysine N-methyltransferase activity, GO:0016279|protein-lysine N-methyltransferase activity, ! cellular carbohydrate biosynthetic process GO:0034637 30 30 0,000 0,01433401 0,01845112 ! scavenger receptor activity GO:0005044 39 30 0,000 0,01433401 0,01844461 ! spliceosome assembly GO:0000245 34 30 0,000 0,01433401 0,01843811 ! oxidoreductase activity, acting on peroxide as acceptor GO:0016684 39 30 0,000 0,01433401 0,01843161 GO:0004601|peroxidase activity, ! mesoderm morphogenesis GO:0048332 37 30 0,000 0,01433401 0,01842511 ! metanephros development GO:0001656 31 30 0,000 0,01433401 0,01841862 ! glutamate receptor activity GO:0008066 35 30 0,000 0,01433401 0,01841214 ! cyclic nucleotide metabolic process GO:0009187 31 30 0,000 0,01433401 0,01840566 ! positive regulation of MAPKKK cascade GO:0043410 36 30 0,000 0,01433401 0,01839918 ! regulation of macrophage differentiation GO:0045649 37 30 0,000 0,01433401 0,01839271 ! positive regulation of myeloid cell differentiation GO:0045639 37 30 0,000 0,01433401 0,01838624 ! negative regulation of myeloid cell differentiation GO:0045638 35 30 0,000 0,01433401 0,01837978 ! cis-trans isomerase activity GO:0016859 32 30 0,000 0,01433401 0,01837332 ! myeloid leukocyte activation GO:0002274 36 30 0,000 0,01433401 0,01836687 ! negative regulation of protein transport GO:0051224 34 30 0,000 0,01433401 0,01836042 ! condensed nuclear chromosome GO:0000794 31 30 0,000 0,01433401 0,01835397 ! cortical cytoskeleton GO:0030863 33 30 0,000 0,01433401 0,01834753 ! protein-lipid complex GO:0032994 41 30 0,000 0,01433401 0,0183411 GO:0034358|plasma lipoprotein particle, ! circadian rhythm GO:0007623 37 30 0,000 0,01433401 0,01833467 ! negative regulation of protein modification process GO:0031400 34 30 0,000 0,01433401 0,01832824 ! phosphatase binding GO:0019902 34 30 0,000 0,01433401 0,01832182 ! acute-phase response GO:0006953 44 30 0,000 0,01433401 0,0183154 ! segmentation GO:0035282 37 30 0,000 0,01433401 0,01830899 ! response to toxin GO:0009636 33 30 0,000 0,01433401 0,01830258 ! cation-transporting ATPase activity GO:0019829 32 30 0,000 0,01433401 0,01829617 ! antigen binding GO:0003823 33 30 0,000 0,01433401 0,01828978 ! regulation of systemic arterial blood pressure GO:0003073 33 30 0,000 0,01433401 0,01828338 ! Golgi-associated vesicle membrane GO:0030660 37 30 0,000 0,01433401 0,01827699 ! ensheathment of neurons GO:0007272 35 30 0,000 0,01433401 0,0182706 GO:0008366|axon ensheathment, ! JAK-STAT cascade GO:0007259 43 30 0,000 0,01433401 0,01826422 ! vesicle localization GO:0051648 31 30 0,000 0,01433401 0,01825784 ! negative regulation of cell adhesion GO:0007162 34 31 0,000 0,01480865 0,01885583 ! maintenance of protein location in cell GO:0032507 32 31 0,000 0,01480865 0,01884925 ! acrosomal vesicle GO:0001669 34 31 0,000 0,01480865 0,01884267 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,01480865 0,0188361 ! protein targeting to membrane GO:0006612 35 31 0,000 0,01480865 0,01882954 ! regulation of axonogenesis GO:0050770 37 31 0,000 0,01480865 0,01882298 ! regulation of T cell differentiation GO:0045580 43 31 0,000 0,01480865 0,01881642 ! formation of primary germ layer GO:0001704 37 31 0,000 0,01480865 0,01880987 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0016903 33 31 0,000 0,01480865 0,01880332 ! endocytic vesicle GO:0030139 33 31 0,000 0,01480865 0,01879678 ! pyridine nucleotide metabolic process GO:0019362 35 31 0,000 0,01480865 0,01879024 ! spermatid differentiation GO:0048515 32 31 0,000 0,01480865 0,01878371 ! negative regulation of catabolic process GO:0009895 34 31 0,000 0,01480865 0,01877718 ! neuron fate commitment GO:0048663 44 31 0,000 0,01480865 0,01877066 ! regulation of cellular catabolic process GO:0031329 35 31 0,000 0,01480865 0,01876414 ! regulation of JAK-STAT cascade GO:0046425 37 31 0,000 0,01480865 0,01875762 ! morphogenesis of embryonic epithelium GO:0016331 36 31 0,000 0,01480865 0,01875111 ! macromolecular complex disassembly GO:0032984 37 31 0,000 0,01480865 0,0187446 ! cell junction assembly GO:0034329 36 31 0,000 0,01480865 0,0187381 ! drug binding GO:0008144 34 31 0,000 0,01480865 0,0187316 ! positive regulation of T cell proliferation GO:0042102 38 31 0,000 0,01480865 0,01872511 ! peptide transport GO:0015833 36 31 0,000 0,01480865 0,01871862 ! DNA integrity checkpoint GO:0031570 51 31 0,000 0,01480865 0,01871214 ! peripheral nervous system development GO:0007422 35 31 0,000 0,01480865 0,01870566 ! I band GO:0031674 34 31 0,000 0,01480865 0,01869919 ! BMP signaling pathway GO:0030509 33 31 0,000 0,01480865 0,01869272 ! adult locomotory behavior GO:0008344 37 31 0,000 0,01480865 0,01868625 ! gene silencing GO:0016458 33 31 0,000 0,01480865 0,01867979 ! negative regulation of adenylate cyclase activity GO:0007194 39 32 0,000 0,01528308 0,01927158 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of secretion GO:0051048 37 32 0,000 0,01528308 0,01926492 ! negative regulation of DNA metabolic process GO:0051053 38 32 0,000 0,01528308 0,01925827 ! phosphotransferase activity, phosphate group as acceptor GO:0016776 49 32 0,000 0,01528308 0,01925162 ! meiosis I GO:0007127 53 32 0,000 0,01528308 0,01924497 ! GPI anchor biosynthetic process GO:0006506 35 32 0,000 0,01528308 0,01923833 GO:0006505|GPI anchor metabolic process, ! unsaturated fatty acid biosynthetic process GO:0006636 33 32 0,000 0,01528308 0,0192317 ! sterol biosynthetic process GO:0016126 40 32 0,000 0,01528308 0,01922507 ! vesicle coat GO:0030120 39 32 0,000 0,01528308 0,01921844 ! cytokine production GO:0001816 32 32 0,000 0,01528308 0,01921182 ! regulation of calcium ion transport GO:0051924 37 32 0,000 0,01528308 0,0192052 ! proteoglycan metabolic process GO:0006029 34 32 0,000 0,01528308 0,01919858 ! sphingoid metabolic process GO:0046519 33 32 0,000 0,01528308 0,01919198 ! multicellular organismal metabolic process GO:0044236 35 32 0,000 0,01528308 0,01918537 ! oxygen binding GO:0019825 33 32 0,000 0,01528308 0,01917877 ! leukocyte chemotaxis GO:0030595 32 32 0,000 0,01528308 0,01917218 GO:0060326|cell chemotaxis, ! negative regulation of leukocyte activation GO:0002695 35 32 0,000 0,01528308 0,01916559 ! hormone biosynthetic process GO:0042446 32 32 0,000 0,01528308 0,019159 ! double-stranded RNA binding GO:0003725 35 32 0,000 0,01528308 0,01915242 ! microtubule organizing center part GO:0044450 46 32 0,000 0,01528308 0,01914584 ! platelet alpha granule lumen GO:0031093 35 33 0,000 0,01575732 0,01973316 ! DNA helicase activity GO:0003678 55 33 0,000 0,01575732 0,01972639 ! neural tube development GO:0021915 37 33 0,000 0,01575732 0,01971962 ! oxidoreductase activity, acting on sulfur group of donors GO:0016667 34 33 0,000 0,01575732 0,01971286 ! pigment biosynthetic process GO:0046148 35 33 0,000 0,01575732 0,0197061 ! organelle envelope lumen GO:0031970 46 33 0,000 0,01575732 0,01969934 ! regulation of cellular ketone metabolic process GO:0010565 46 33 0,000 0,01575732 0,0196926 ! negative regulation of DNA binding GO:0043392 39 33 0,000 0,01575732 0,01968585 ! NAD or NADH binding GO:0051287 36 33 0,000 0,01575732 0,01967911 ! nucleotide catabolic process GO:0009166 35 33 0,000 0,01575732 0,01967238 ! B cell differentiation GO:0030183 37 33 0,000 0,01575732 0,01966565 ! regulation of Wnt receptor signaling pathway GO:0030111 36 33 0,000 0,01575732 0,01965892 ! aerobic respiration GO:0009060 35 33 0,000 0,01575732 0,0196522 ! embryonic organ development GO:0048568 41 33 0,000 0,01575732 0,01964548 ! placenta development GO:0001890 39 33 0,000 0,01575732 0,01963877 ! protein serine/threonine phosphatase complex GO:0008287 37 33 0,000 0,01575732 0,01963207 ! tissue remodeling GO:0048771 37 33 0,000 0,01575732 0,01962536 ! flagellum GO:0019861 34 33 0,000 0,01575732 0,01961866 ! L-amino acid transmembrane transporter activity GO:0015179 37 33 0,000 0,01575732 0,01961197 ! Rho protein signal transduction GO:0007266 35 33 0,000 0,01575732 0,01960528 ! cysteine-type endopeptidase inhibitor activity GO:0004869 35 33 0,000 0,01575732 0,0195986 ! odontogenesis GO:0042476 39 34 0,000 0,01623135 0,0201813 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,01623135 0,02017443 ! lipid homeostasis GO:0055088 37 34 0,000 0,01623135 0,02016756 ! telencephalon development GO:0021537 36 34 0,000 0,01623135 0,02016069 ! negative regulation of hydrolase activity GO:0051346 36 34 0,000 0,01623135 0,02015383 ! clathrin coat GO:0030118 41 34 0,000 0,01623135 0,02014697 ! cell growth GO:0016049 36 34 0,000 0,01623135 0,02014012 ! protein polymerization GO:0051258 38 34 0,000 0,01623135 0,02013327 ! condensed chromosome kinetochore GO:0000777 52 34 0,000 0,01623135 0,02012643 ! learning GO:0007612 51 34 0,000 0,01623135 0,02011959 ! keratinization GO:0031424 40 34 0,000 0,01623135 0,02011275 ! ovulation cycle process GO:0022602 35 34 0,000 0,01623135 0,02010592 ! regulation of striated muscle tissue development GO:0016202 40 34 0,000 0,01623135 0,0200991 ! steroid hormone receptor binding GO:0035258 44 34 0,000 0,01623135 0,02009228 ! regulation of protein import into nucleus GO:0042306 36 34 0,000 0,01623135 0,02008546 ! erythrocyte homeostasis GO:0034101 40 34 0,000 0,01623135 0,02007865 ! amino acid binding GO:0016597 40 34 0,000 0,01623135 0,02007185 ! regulation of protein stability GO:0031647 35 34 0,000 0,01623135 0,02006504 ! specific RNA polymerase II transcription factor activity GO:0003704 41 34 0,000 0,01623135 0,02005825 ! glycogen metabolic process GO:0005977 48 34 0,000 0,01623135 0,02005145 ! pyrimidine nucleotide metabolic process GO:0006220 41 34 0,000 0,01623135 0,02004467 ! acetylglucosaminyltransferase activity GO:0008375 40 34 0,000 0,01623135 0,02003788 ! epithelial tube morphogenesis GO:0060562 38 34 0,000 0,01623135 0,02003111 ! positive regulation of transcription factor activity GO:0051091 49 35 0,000 0,01670517 0,02060888 GO:0090047|positive regulation of transcription regulator activity, ! positive regulation of DNA metabolic process GO:0051054 53 35 0,000 0,01670517 0,02060192 ! response to estrogen stimulus GO:0043627 48 35 0,000 0,01670517 0,02059495 ! inner ear morphogenesis GO:0042472 46 35 0,000 0,01670517 0,02058799 ! MHC protein complex GO:0042611 50 35 0,000 0,01670517 0,02058104 ! alcohol biosynthetic process GO:0046165 41 35 0,000 0,01670517 0,02057409 ! vesicle lumen GO:0031983 38 35 0,000 0,01670517 0,02056715 GO:0060205|cytoplasmic membrane-bounded vesicle lumen, ! female gonad development GO:0008585 37 35 0,000 0,01670517 0,02056021 ! mesenchymal cell development GO:0014031 40 35 0,000 0,01670517 0,02055328 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! neutral lipid metabolic process GO:0006638 47 35 0,000 0,01670517 0,02054635 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 37 35 0,000 0,01670517 0,02053942 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 41 35 0,000 0,01670517 0,0205325 ! regulation of proteolysis GO:0030162 37 35 0,000 0,01670517 0,02052559 ! ovulation cycle GO:0042698 37 35 0,000 0,01670517 0,02051868 ! intramolecular oxidoreductase activity GO:0016860 35 35 0,000 0,01670517 0,02051177 ! positive regulation of catabolic process GO:0009896 38 35 0,000 0,01670517 0,02050487 ! collagen GO:0005581 54 35 0,000 0,01670517 0,02049797 ! glucan metabolic process GO:0044042 49 35 0,000 0,01670517 0,02049108 GO:0006073|cellular glucan metabolic process, ! regulation of muscle development GO:0048634 42 35 0,000 0,01670517 0,02048419 ! ER to Golgi vesicle-mediated transport GO:0006888 43 35 0,000 0,01670517 0,02047731 ! histone methyltransferase activity GO:0042054 40 35 0,000 0,01670517 0,02047043 ! cation:sugar symporter activity GO:0005402 37 35 0,000 0,01670517 0,02046355 GO:0005351|sugar:hydrogen symporter activity, ! carbohydrate homeostasis GO:0033500 49 35 0,000 0,01670517 0,02045669 GO:0042593|glucose homeostasis, ! cytosolic small ribosomal subunit GO:0022627 36 35 0,000 0,01670517 0,02044982 ! maintenance of protein location GO:0045185 45 35 0,000 0,01670517 0,02044296 ! polyol metabolic process GO:0019751 46 35 0,000 0,01670517 0,0204361 ! androgen receptor signaling pathway GO:0030521 47 35 0,000 0,01670517 0,02042925 ! cytokinesis GO:0000910 38 35 0,000 0,01670517 0,02042241 ! O-acyltransferase activity GO:0008374 36 35 0,000 0,01670517 0,02041557 ! purinergic nucleotide receptor activity GO:0001614 40 36 0,000 0,01717879 0,02098736 GO:0016502|nucleotide receptor activity, ! mitochondrial respiratory chain complex I GO:0005747 37 36 0,000 0,01717879 0,02098033 GO:0030964|NADH dehydrogenase complex, GO:0045271|respiratory chain complex I, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 42 36 0,000 0,01717879 0,02097331 ! positive regulation of neurogenesis GO:0050769 38 36 0,000 0,01717879 0,02096629 ! SMAD binding GO:0046332 39 36 0,000 0,01717879 0,02095928 ! negative regulation of cell activation GO:0050866 40 36 0,000 0,01717879 0,02095227 ! inositol or phosphatidylinositol kinase activity GO:0004428 51 36 0,000 0,01717879 0,02094527 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 41 36 0,000 0,01717879 0,02093827 GO:0006956|complement activation, ! glial cell differentiation GO:0010001 38 36 0,000 0,01717879 0,02093128 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 36 0,000 0,01717879 0,02092429 ! hormone-mediated signaling GO:0009755 41 36 0,000 0,01717879 0,0209173 ! nucleus organization GO:0006997 42 36 0,000 0,01717879 0,02091032 ! protein tyrosine/serine/threonine phosphatase activity GO:0008138 44 36 0,000 0,01717879 0,02090335 ! di-, tri-valent inorganic cation transmembrane transporter activity GO:0015082 42 36 0,000 0,01717879 0,02089638 ! carboxypeptidase activity GO:0004180 37 36 0,000 0,01717879 0,02088941 ! energy coupled proton transport, down electrochemical gradient GO:0015985 37 36 0,000 0,01717879 0,02088245 GO:0015986|ATP synthesis coupled proton transport, ! female gamete generation GO:0007292 39 36 0,000 0,01717879 0,0208755 ! maintenance of location in cell GO:0051651 38 36 0,000 0,01717879 0,02086855 ! activation of adenylate cyclase activity GO:0007190 44 37 0,000 0,01765222 0,02143651 ! regulation of hormone secretion GO:0046883 43 37 0,000 0,01765222 0,02142938 ! sugar transmembrane transporter activity GO:0051119 39 37 0,000 0,01765222 0,02142225 GO:0015144|carbohydrate transmembrane transporter activity, ! regulation of Rab protein signal transduction GO:0032483 40 37 0,000 0,01765222 0,02141513 GO:0032313|regulation of Rab GTPase activity, ! regulation of action potential in neuron GO:0019228 44 37 0,000 0,01765222 0,02140801 ! glycerol ether metabolic process GO:0006662 49 37 0,000 0,01765222 0,02140089 ! endoribonuclease activity GO:0004521 48 37 0,000 0,01765222 0,02139378 ! hindbrain development GO:0030902 43 37 0,000 0,01765222 0,02138668 ! isoprenoid metabolic process GO:0006720 41 37 0,000 0,01765222 0,02137958 ! pigmentation GO:0043473 51 37 0,000 0,01765222 0,02137248 ! regulation of neuron projection development GO:0010975 43 37 0,000 0,01765222 0,02136539 ! condensed chromosome, centromeric region GO:0000779 55 37 0,000 0,01765222 0,0213583 ! metalloexopeptidase activity GO:0008235 39 37 0,000 0,01765222 0,02135122 ! monocarboxylic acid transport GO:0015718 43 37 0,000 0,01765222 0,02134414 ! sensory perception of taste GO:0050909 37 37 0,000 0,01765222 0,02133707 ! cell junction organization GO:0034330 44 37 0,000 0,01765222 0,02133 ! skeletal muscle fiber development GO:0048741 41 37 0,000 0,01765222 0,02132294 ! development of primary female sexual characteristics GO:0046545 40 37 0,000 0,01765222 0,02131588 GO:0046660|female sex differentiation, ! NADH dehydrogenase (ubiquinone) activity GO:0008137 38 37 0,000 0,01765222 0,02130883 GO:0050136|NADH dehydrogenase (quinone) activity, GO:0003954|NADH dehydrogenase activity, ! ion transmembrane transport GO:0034220 38 37 0,000 0,01765222 0,02130178 ! regulation of lymphocyte mediated immunity GO:0002706 43 37 0,000 0,01765222 0,02129474 ! coated pit GO:0005905 44 37 0,000 0,01765222 0,0212877 ! positive regulation of adenylate cyclase activity GO:0045762 45 38 0,000 0,01812543 0,02185115 ! regulation of translational initiation GO:0006446 50 38 0,000 0,01812543 0,02184393 ! negative regulation of binding GO:0051100 44 38 0,000 0,01812543 0,02183672 ! organic ether metabolic process GO:0018904 50 38 0,000 0,01812543 0,02182951 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 43 38 0,000 0,01812543 0,0218223 ! regulation of lymphocyte differentiation GO:0045619 51 38 0,000 0,01812543 0,0218151 ! carbon-carbon lyase activity GO:0016830 41 38 0,000 0,01812543 0,02180791 ! hydro-lyase activity GO:0016836 44 38 0,000 0,01812543 0,02180072 ! synapse organization GO:0050808 43 38 0,000 0,01812543 0,02179353 ! viral infectious cycle GO:0019058 40 38 0,000 0,01812543 0,02178635 ! phosphoinositide biosynthetic process GO:0046489 41 38 0,000 0,01812543 0,02177918 ! organic anion transport GO:0015711 42 38 0,000 0,01812543 0,02177201 ! non-membrane spanning protein tyrosine kinase activity GO:0004715 52 38 0,000 0,01812543 0,02176484 ! monosaccharide binding GO:0048029 41 38 0,000 0,01812543 0,02175768 ! muscle fiber development GO:0048747 42 38 0,000 0,01812543 0,02175052 ! development of primary male sexual characteristics GO:0046546 46 38 0,000 0,01812543 0,02174337 ! phagocytosis GO:0006909 44 38 0,000 0,01812543 0,02173622 ! regulation of ARF protein signal transduction GO:0032012 44 38 0,000 0,01812543 0,02172908 ! extrinsic to plasma membrane GO:0019897 43 38 0,000 0,01812543 0,02172194 ! cytosolic large ribosomal subunit GO:0022625 43 38 0,000 0,01812543 0,0217148 ! Rab GTPase activator activity GO:0005097 41 38 0,000 0,01812543 0,02170768 ! cellular response to insulin stimulus GO:0032869 47 38 0,000 0,01812543 0,02170055 ! monocarboxylic acid binding GO:0033293 44 39 0,000 0,01859845 0,02225956 ! induction of apoptosis by extracellular signals GO:0008624 44 39 0,000 0,01859845 0,02225226 ! heterocycle biosynthetic process GO:0018130 51 39 0,000 0,01859845 0,02224496 ! positive regulation of DNA binding GO:0043388 53 39 0,000 0,01859845 0,02223767 ! T cell differentiation GO:0030217 64 39 0,000 0,01859845 0,02223039 ! DNA-dependent ATPase activity GO:0008094 63 39 0,000 0,01859845 0,02222311 ! cell fate specification GO:0001708 55 39 0,000 0,01859845 0,02221583 ! positive regulation of cyclase activity GO:0031281 46 39 0,000 0,01859845 0,02220856 ! regulation of adaptive immune response GO:0002819 44 39 0,000 0,01859845 0,02220129 ! regulation of cell morphogenesis involved in differentiation GO:0010769 45 39 0,000 0,01859845 0,02219403 ! receptor-mediated endocytosis GO:0006898 44 39 0,000 0,01859845 0,02218677 ! regulation of metal ion transport GO:0010959 45 39 0,000 0,01859845 0,02217952 ! energy reserve metabolic process GO:0006112 53 39 0,000 0,01859845 0,02217227 ! amine receptor activity GO:0008227 48 39 0,000 0,01859845 0,02216502 ! cytoskeleton-dependent intracellular transport GO:0030705 42 39 0,000 0,01859845 0,02215779 ! embryonic skeletal system morphogenesis GO:0048704 46 39 0,000 0,01859845 0,02215055 ! neuropeptide receptor activity GO:0008188 41 39 0,000 0,01859845 0,02214332 ! double-strand break repair GO:0006302 70 39 0,000 0,01859845 0,0221361 ! pigment metabolic process GO:0042440 43 39 0,000 0,01859845 0,02212888 ! RNA modification GO:0009451 39 39 0,000 0,01859845 0,02212166 ! regulation of intracellular protein transport GO:0033157 43 40 0,000 0,01907126 0,02267665 ! peroxisomal membrane GO:0005778 44 40 0,000 0,01907126 0,02266926 GO:0031903|microbody membrane, ! actin filament binding GO:0051015 41 40 0,000 0,01907126 0,02266188 ! positive regulation of cell development GO:0010720 43 40 0,000 0,01907126 0,0226545 ! ribonucleoside metabolic process GO:0009119 47 40 0,000 0,01907126 0,02264712 ! biopolymer methylation GO:0043414 45 40 0,000 0,01907126 0,02263975 ! neuron migration GO:0001764 43 40 0,000 0,01907126 0,02263239 ! regulation of protein secretion GO:0050708 45 40 0,000 0,01907126 0,02262503 ! oxidoreduction coenzyme metabolic process GO:0006733 45 40 0,000 0,01907126 0,02261767 ! dorsal/ventral pattern formation GO:0009953 42 40 0,000 0,01907126 0,02261032 ! regulation of actin filament polymerization GO:0030833 53 40 0,000 0,01907126 0,02260298 ! positive regulation of defense response GO:0031349 41 40 0,000 0,01907126 0,02259564 ! mammary gland development GO:0030879 47 40 0,000 0,01907126 0,0225883 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 50 40 0,000 0,01907126 0,02258097 ! neuropeptide binding GO:0042923 42 40 0,000 0,01907126 0,02257364 ! regulation of tube size GO:0035150 44 40 0,000 0,01907126 0,02256632 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 42 40 0,000 0,01907126 0,022559 ! positive regulation of gene-specific transcription GO:0043193 46 40 0,000 0,01907126 0,02255169 ! regulation of leukocyte mediated immunity GO:0002703 46 40 0,000 0,01907126 0,02254438 ! inorganic anion transmembrane transporter activity GO:0015103 43 40 0,000 0,01907126 0,02253708 ! chromatin remodeling GO:0006338 44 40 0,000 0,01907126 0,02252978 ! solute:hydrogen symporter activity GO:0015295 44 40 0,000 0,01907126 0,02252249 ! protein amino acid N-linked glycosylation GO:0006487 46 41 0,000 0,01954387 0,02307315 ! Notch signaling pathway GO:0007219 46 41 0,000 0,01954387 0,02306569 ! keratin filament GO:0045095 44 41 0,000 0,01954387 0,02305823 ! peptide metabolic process GO:0006518 42 41 0,000 0,01954387 0,02305077 ! polysaccharide biosynthetic process GO:0000271 42 41 0,000 0,01954387 0,02304332 ! late endosome membrane GO:0031902 45 41 0,000 0,01954387 0,02303588 ! icosanoid metabolic process GO:0006690 51 41 0,000 0,01954387 0,02302844 ! positive regulation of lyase activity GO:0051349 48 41 0,000 0,01954387 0,023021 ! integral to endoplasmic reticulum membrane GO:0030176 43 41 0,000 0,01954387 0,02301357 ! lamellipodium GO:0030027 56 41 0,000 0,01954387 0,02300614 ! glycolysis GO:0006096 43 41 0,000 0,01954387 0,02299872 ! branching morphogenesis of a tube GO:0048754 54 41 0,000 0,01954387 0,02299131 ! nucleobase, nucleoside, nucleotide kinase activity GO:0019205 51 41 0,000 0,01954387 0,0229839 ! proton-transporting two-sector ATPase complex GO:0016469 42 41 0,000 0,01954387 0,02297649 ! response to reactive oxygen species GO:0000302 49 42 0,000 0,02001628 0,02352429 ! cellular amide metabolic process GO:0043603 56 42 0,000 0,02001628 0,02351671 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor GO:0016655 43 42 0,000 0,02001628 0,02350914 ! ER-Golgi intermediate compartment GO:0005793 52 42 0,000 0,02001628 0,02350157 ! regulation of multicellular organism growth GO:0040014 46 42 0,000 0,02001628 0,02349401 ! integral to Golgi membrane GO:0030173 55 42 0,000 0,02001628 0,02348645 ! nuclear export GO:0051168 46 42 0,000 0,02001628 0,0234789 ! developmental growth GO:0048589 45 42 0,000 0,02001628 0,02347136 ! structural constituent of muscle GO:0008307 46 42 0,000 0,02001628 0,02346381 ! mitochondrial transport GO:0006839 45 42 0,000 0,02001628 0,02345628 ! protein methyltransferase activity GO:0008276 49 42 0,000 0,02001628 0,02344874 ! metal cluster binding GO:0051540 47 42 0,000 0,02001628 0,02344122 GO:0051536|iron-sulfur cluster binding, ! feeding behavior GO:0007631 48 42 0,000 0,02001628 0,02343369 ! protein serine/threonine phosphatase activity GO:0004722 45 42 0,000 0,02001628 0,02342617 ! ribonucleoprotein complex assembly GO:0022618 47 42 0,000 0,02001628 0,02341866 ! RNA catabolic process GO:0006401 49 43 0,000 0,02048848 0,02396345 ! ear morphogenesis GO:0042471 56 43 0,000 0,02048848 0,02395577 ! cellular amino acid biosynthetic process GO:0008652 49 43 0,000 0,02048848 0,02394809 ! regulation of epithelial cell proliferation GO:0050678 50 43 0,000 0,02048848 0,02394042 ! positive regulation of growth GO:0045927 47 43 0,000 0,02048848 0,02393275 ! cell recognition GO:0008037 51 43 0,000 0,02048848 0,02392509 ! positive regulation of cytokine production GO:0001819 46 43 0,000 0,02048848 0,02391744 ! epithelial cell differentiation GO:0030855 56 43 0,000 0,02048848 0,02390979 ! gliogenesis GO:0042063 46 43 0,000 0,02048848 0,02390214 ! endosome transport GO:0016197 48 43 0,000 0,02048848 0,0238945 ! striated muscle contraction GO:0006941 45 43 0,000 0,02048848 0,02388686 ! positive regulation of cytokine biosynthetic process GO:0042108 48 43 0,000 0,02048848 0,02387923 ! antioxidant activity GO:0016209 53 43 0,000 0,02048848 0,0238716 ! sulfur compound biosynthetic process GO:0044272 47 43 0,000 0,02048848 0,02386398 ! activation of caspase activity GO:0006919 60 43 0,000 0,02048848 0,02385637 ! vascular process in circulatory system GO:0003018 48 43 0,000 0,02048848 0,02384875 ! histone modification GO:0016570 45 43 0,000 0,02048848 0,02384115 ! cellular amino acid derivative biosynthetic process GO:0042398 55 43 0,000 0,02048848 0,02383354 ! regulation of nucleocytoplasmic transport GO:0046822 46 44 0,000 0,02096049 0,02437484 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 50 44 0,000 0,02096049 0,02436707 ! negative regulation of cell migration GO:0030336 53 44 0,000 0,02096049 0,02435931 ! ATP synthesis coupled electron transport GO:0042773 45 44 0,000 0,02096049 0,02435155 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! nucleoside monophosphate biosynthetic process GO:0009124 50 44 0,000 0,02096049 0,02434379 ! chemokine activity GO:0008009 48 44 0,000 0,02096049 0,02433605 ! ruffle GO:0001726 50 44 0,000 0,02096049 0,0243283 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0015662 51 44 0,000 0,02096049 0,02432057 ! regulation of neuron apoptosis GO:0043523 58 44 0,000 0,02096049 0,02431283 ! cartilage development GO:0051216 48 44 0,000 0,02096049 0,0243051 ! membrane fusion GO:0006944 52 44 0,000 0,02096049 0,02429738 ! channel regulator activity GO:0016247 54 44 0,000 0,02096049 0,02428966 ! excretion GO:0007588 53 44 0,000 0,02096049 0,02428195 ! male sex differentiation GO:0046661 52 44 0,000 0,02096049 0,02427424 ! protein phosphatase regulator activity GO:0019888 50 44 0,000 0,02096049 0,02426654 ! amino acid activation GO:0043038 45 44 0,000 0,02096049 0,02425884 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! microbody part GO:0044438 48 44 0,000 0,02096049 0,02425114 GO:0044439|peroxisomal part, ! positive regulation of binding GO:0051099 59 45 0,000 0,02143229 0,02478915 ! solute:sodium symporter activity GO:0015370 51 45 0,000 0,02143229 0,0247813 ! transferase activity, transferring pentosyl groups GO:0016763 50 45 0,000 0,02143229 0,02477344 ! organellar ribosome GO:0000313 46 45 0,000 0,02143229 0,0247656 GO:0005761|mitochondrial ribosome, ! platelet alpha granule GO:0031091 49 45 0,000 0,02143229 0,02475775 ! intrinsic to Golgi membrane GO:0031228 60 45 0,000 0,02143229 0,02474992 ! transport vesicle GO:0030133 53 45 0,000 0,02143229 0,02474209 ! regulation of endocytosis GO:0030100 52 45 0,000 0,02143229 0,02473426 ! ligase activity, forming carbon-oxygen bonds GO:0016875 47 45 0,000 0,02143229 0,02472644 GO:0016876|ligase activity, forming aminoacyl-tRNA and related compounds, GO:0004812|aminoacyl-tRNA ligase activity, ! nuclear matrix GO:0016363 56 45 0,000 0,02143229 0,02471862 ! unsaturated fatty acid metabolic process GO:0033559 55 45 0,000 0,02143229 0,02471081 ! regulation of T cell proliferation GO:0042129 53 45 0,000 0,02143229 0,024703 ! regulation of myeloid leukocyte differentiation GO:0002761 54 45 0,000 0,02143229 0,0246952 ! coated vesicle membrane GO:0030662 52 45 0,000 0,02143229 0,0246874 ! covalent chromatin modification GO:0016569 47 45 0,000 0,02143229 0,02467961 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 51 45 0,000 0,02143229 0,02467182 ! synaptosome GO:0019717 50 45 0,000 0,02143229 0,02466403 ! chemokine receptor binding GO:0042379 50 45 0,000 0,02143229 0,02465626 ! regulation of action potential GO:0001508 56 46 0,000 0,02190389 0,02519085 ! immunoglobulin mediated immune response GO:0016064 51 46 0,000 0,02190389 0,02518291 ! phosphatase regulator activity GO:0019208 53 46 0,000 0,02190389 0,02517498 ! regulation of inflammatory response GO:0050727 49 46 0,000 0,02190389 0,02516705 ! eye morphogenesis GO:0048592 57 46 0,000 0,02190389 0,02515913 ! regulation of JNK cascade GO:0046328 53 46 0,000 0,02190389 0,02515121 ! methylation GO:0032259 51 46 0,000 0,02190389 0,02514329 ! positive regulation of protein transport GO:0051222 50 46 0,000 0,02190389 0,02513538 ! regulation of ion transport GO:0043269 54 46 0,000 0,02190389 0,02512748 ! leukocyte migration GO:0050900 49 46 0,000 0,02190389 0,02511958 ! neuromuscular process GO:0050905 56 46 0,000 0,02190389 0,02511169 ! sulfotransferase activity GO:0008146 54 46 0,000 0,02190389 0,0251038 ! JNK cascade GO:0007254 48 46 0,000 0,02190389 0,02509591 ! SH3/SH2 adaptor activity GO:0005070 52 46 0,000 0,02190389 0,02508803 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 54 47 0,000 0,02237528 0,02561991 ! auxiliary transport protein activity GO:0015457 58 47 0,000 0,02237528 0,02561187 ! regulation of actin polymerization or depolymerization GO:0008064 60 47 0,000 0,02237528 0,02560384 ! microtubule binding GO:0008017 61 47 0,000 0,02237528 0,02559581 ! morphogenesis of a branching structure GO:0001763 70 47 0,000 0,02237528 0,02558779 ! carbon-oxygen lyase activity GO:0016835 53 47 0,000 0,02237528 0,02557977 ! regulation of protein polymerization GO:0032271 60 47 0,000 0,02237528 0,02557175 ! viral reproductive process GO:0022415 53 47 0,000 0,02237528 0,02556375 ! negative regulation of immune system process GO:0002683 58 47 0,000 0,02237528 0,02555574 ! mRNA binding GO:0003729 65 47 0,000 0,02237528 0,02554774 ! response to insulin stimulus GO:0032868 57 47 0,000 0,02237528 0,02553975 ! axon GO:0030424 53 48 0,000 0,02284648 0,02606943 ! protein amino acid lipidation GO:0006497 53 48 0,000 0,02284648 0,02606127 ! stress-activated protein kinase signaling pathway GO:0031098 50 48 0,000 0,02284648 0,02605313 ! proteasome complex GO:0000502 50 48 0,000 0,02284648 0,02604499 ! glutamine family amino acid metabolic process GO:0009064 62 48 0,000 0,02284648 0,02603685 ! protein homooligomerization GO:0051260 63 48 0,000 0,02284648 0,02602872 ! regulation of cell projection organization GO:0031344 54 48 0,000 0,02284648 0,02602059 ! kinetochore GO:0000776 69 48 0,000 0,02284648 0,02601247 ! positive regulation of caspase activity GO:0043280 65 48 0,000 0,02284648 0,02600435 GO:0010952|positive regulation of peptidase activity, ! detection of stimulus involved in sensory perception GO:0050906 53 48 0,000 0,02284648 0,02599624 ! growth factor receptor binding GO:0070851 58 48 0,000 0,02284648 0,02598814 ! N-methyltransferase activity GO:0008170 53 48 0,000 0,02284648 0,02598004 ! inner ear development GO:0048839 60 48 0,000 0,02284648 0,02597194 ! excitatory extracellular ligand-gated ion channel activity GO:0005231 57 48 0,000 0,02284648 0,02596385 ! amino acid transmembrane transporter activity GO:0015171 53 48 0,000 0,02284648 0,02595576 ! chromatin remodeling complex GO:0016585 54 48 0,000 0,02284648 0,02594768 ! B cell mediated immunity GO:0019724 53 48 0,000 0,02284648 0,02593961 ! steroid hormone receptor activity GO:0003707 61 48 0,000 0,02284648 0,02593154 ! regulation of cell shape GO:0008360 55 48 0,000 0,02284648 0,02592347 ! establishment of organelle localization GO:0051656 58 48 0,000 0,02284648 0,02591541 ! cell cortex part GO:0044448 54 48 0,000 0,02284648 0,02590735 ! transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016765 52 49 0,000 0,02331747 0,02643323 ! regulation of neurotransmitter levels GO:0001505 55 49 0,000 0,02331747 0,02642502 ! oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 54 49 0,000 0,02331747 0,02641681 ! response to temperature stimulus GO:0009266 57 49 0,000 0,02331747 0,02640861 ! Golgi-associated vesicle GO:0005798 59 49 0,000 0,02331747 0,02640042 ! lipid modification GO:0030258 55 49 0,000 0,02331747 0,02639222 ! synaptic vesicle GO:0008021 56 49 0,000 0,02331747 0,02638404 ! regulation of gene expression, epigenetic GO:0040029 64 49 0,000 0,02331747 0,02637586 ! pyridoxal phosphate binding GO:0030170 63 49 0,000 0,02331747 0,02636768 GO:0070279|vitamin B6 binding, ! exonuclease activity GO:0004527 79 49 0,000 0,02331747 0,02635951 ! maintenance of location GO:0051235 62 49 0,000 0,02331747 0,02635134 ! negative regulation of cell motion GO:0051271 60 49 0,000 0,02331747 0,02634318 ! regulation of actin filament length GO:0030832 62 49 0,000 0,02331747 0,02633503 ! nuclear periphery GO:0034399 60 49 0,000 0,02331747 0,02632688 ! regulation of muscle contraction GO:0006937 57 49 0,000 0,02331747 0,02631873 ! respiratory electron transport chain GO:0022904 51 50 0,000 0,02378826 0,02684181 ! DNA damage response, signal transduction GO:0042770 84 50 0,000 0,02378826 0,02683351 ! cytokine-mediated signaling pathway GO:0019221 56 50 0,000 0,02378826 0,02682522 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016811 51 50 0,000 0,02378826 0,02681693 ! embryonic skeletal system development GO:0048706 59 50 0,000 0,02378826 0,02680865 ! glucose catabolic process GO:0006007 54 50 0,000 0,02378826 0,02680037 ! aging GO:0007568 92 50 0,000 0,02378826 0,02679209 ! generation of a signal involved in cell-cell signaling GO:0003001 59 50 0,000 0,02378826 0,02678382 ! heart morphogenesis GO:0003007 57 50 0,000 0,02378826 0,02677556 ! integrin binding GO:0005178 56 50 0,000 0,02378826 0,0267673 ! detection of abiotic stimulus GO:0009582 56 50 0,000 0,02378826 0,02675905 ! regulation of angiogenesis GO:0045765 56 51 0,000 0,02425885 0,02727999 ! positive regulation of cell migration GO:0030335 63 51 0,000 0,02425885 0,02727159 ! regulation of ossification GO:0030278 59 51 0,000 0,02425885 0,02726318 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 60 51 0,000 0,02425885 0,02725479 ! positive regulation of organelle organization GO:0010638 69 51 0,000 0,02425885 0,0272464 ! cellular polysaccharide metabolic process GO:0044264 65 51 0,000 0,02425885 0,02723801 ! endocrine system development GO:0035270 55 51 0,000 0,02425885 0,02722963 ! germ cell development GO:0007281 56 51 0,000 0,02425885 0,02722125 ! transferase activity, transferring sulfur-containing groups GO:0016782 60 52 0,000 0,02472924 0,02774055 ! regulation of cellular component size GO:0032535 66 52 0,000 0,02472924 0,02773202 ! carbohydrate transport GO:0008643 57 52 0,000 0,02472924 0,0277235 ! ubiquitin thiolesterase activity GO:0004221 64 52 0,000 0,02472924 0,02771498 ! nucleoside monophosphate metabolic process GO:0009123 58 52 0,000 0,02472924 0,02770647 ! cell maturation GO:0048469 68 52 0,000 0,02472924 0,02769796 ! regulation of intracellular transport GO:0032386 57 52 0,000 0,02472924 0,02768946 ! vesicle organization GO:0016050 59 52 0,000 0,02472924 0,02768097 ! kidney development GO:0001822 55 52 0,000 0,02472924 0,02767248 ! cellular component disassembly GO:0022411 69 52 0,000 0,02472924 0,02766399 ! cell redox homeostasis GO:0045454 57 52 0,000 0,02472924 0,02765551 ! lipoprotein biosynthetic process GO:0042158 57 52 0,000 0,02472924 0,02764703 ! lipid transporter activity GO:0005319 58 52 0,000 0,02472924 0,02763856 ! cytokine receptor activity GO:0004896 54 52 0,000 0,02472924 0,0276301 ! antiporter activity GO:0015297 53 52 0,000 0,02472924 0,02762164 ! embryonic limb morphogenesis GO:0030326 62 53 0,000 0,02519943 0,0281382 GO:0035113|embryonic appendage morphogenesis, ! glycosaminoglycan metabolic process GO:0030203 60 53 0,000 0,02519943 0,02812959 ! keratinocyte differentiation GO:0030216 60 53 0,000 0,02519943 0,02812099 ! N-acetyltransferase activity GO:0008080 59 53 0,000 0,02519943 0,02811239 ! basement membrane GO:0005604 55 53 0,000 0,02519943 0,02810379 ! water-soluble vitamin metabolic process GO:0006767 59 53 0,000 0,02519943 0,0280952 ! negative regulation of response to stimulus GO:0048585 68 53 0,000 0,02519943 0,02808662 ! viral reproduction GO:0016032 59 53 0,000 0,02519943 0,02807804 ! chloride transport GO:0006821 60 53 0,000 0,02519943 0,02806947 ! oxygen and reactive oxygen species metabolic process GO:0006800 58 53 0,000 0,02519943 0,0280609 ! regulation of protein catabolic process GO:0042176 56 53 0,000 0,02519943 0,02805234 ! regulation of DNA replication GO:0006275 75 53 0,000 0,02519943 0,02804378 ! heterocycle catabolic process GO:0046700 56 53 0,000 0,02519943 0,02803523 ! integrin-mediated signaling pathway GO:0007229 59 53 0,000 0,02519943 0,02802668 ! single fertilization GO:0007338 58 53 0,000 0,02519943 0,02801814 ! activation of phospholipase C activity GO:0007202 61 54 0,000 0,02566941 0,028532 GO:0010863|positive regulation of phospholipase C activity, ! double-stranded DNA binding GO:0003690 63 54 0,000 0,02566941 0,02852331 ! mitochondrial respiratory chain GO:0005746 55 54 0,000 0,02566941 0,02851462 ! nucleoside metabolic process GO:0009116 62 54 0,000 0,02566941 0,02850594 ! coated membrane GO:0048475 65 54 0,000 0,02566941 0,02849727 GO:0030117|membrane coat, ! nucleosome GO:0000786 59 54 0,000 0,02566941 0,0284886 ! regulation of protein complex assembly GO:0043254 67 54 0,000 0,02566941 0,02847993 ! cellular defense response GO:0006968 61 54 0,000 0,02566941 0,02847127 ! gastrulation GO:0007369 62 54 0,000 0,02566941 0,02846262 ! dendrite GO:0030425 60 55 0,000 0,0261392 0,02897471 ! regulation of mitosis GO:0007088 79 55 0,000 0,0261392 0,02896591 GO:0051783|regulation of nuclear division, ! positive regulation of phospholipase activity GO:0010518 62 55 0,000 0,0261392 0,02895712 ! respiratory chain GO:0070469 57 55 0,000 0,0261392 0,02894833 ! coenzyme biosynthetic process GO:0009108 68 55 0,000 0,0261392 0,02893954 ! extracellular matrix organization GO:0030198 77 55 0,000 0,0261392 0,02893076 ! positive regulation of cell motion GO:0051272 69 55 0,000 0,0261392 0,02892199 ! protein amino acid autophosphorylation GO:0046777 61 55 0,000 0,0261392 0,02891322 ! translation initiation factor activity GO:0003743 66 55 0,000 0,0261392 0,02890445 ! steroid hormone receptor signaling pathway GO:0030518 70 55 0,000 0,0261392 0,02889569 ! regulation of bone remodeling GO:0046850 64 56 0,000 0,02660878 0,02940588 ! heat shock protein binding GO:0031072 62 56 0,000 0,02660878 0,02939698 ! late endosome GO:0005770 60 56 0,000 0,02660878 0,02938808 ! regulation of phospholipase activity GO:0010517 63 56 0,000 0,02660878 0,02937918 ! sphingolipid metabolic process GO:0006665 60 56 0,000 0,02660878 0,02937029 ! intrinsic to endoplasmic reticulum membrane GO:0031227 61 56 0,000 0,02660878 0,02936141 ! ribonuclease activity GO:0004540 67 56 0,000 0,02660878 0,02935253 ! positive regulation of T cell activation GO:0050870 74 56 0,000 0,02660878 0,02934366 ! mesoderm development GO:0007498 67 56 0,000 0,02660878 0,02933479 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 61 56 0,000 0,02660878 0,02932593 ! antigen processing and presentation GO:0019882 73 56 0,000 0,02660878 0,02931707 ! proton transport GO:0015992 59 56 0,000 0,02660878 0,02930822 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 68 57 0,000 0,02707816 0,02981622 ! chromosome segregation GO:0007059 92 57 0,000 0,02707816 0,02980722 ! glycerophospholipid biosynthetic process GO:0046474 71 57 0,000 0,02707816 0,02979823 ! diacylglycerol binding GO:0019992 65 57 0,000 0,02707816 0,02978924 ! B cell activation GO:0042113 63 57 0,000 0,02707816 0,02978026 ! small ribosomal subunit GO:0015935 58 57 0,000 0,02707816 0,02977128 ! detection of external stimulus GO:0009581 64 57 0,000 0,02707816 0,02976231 ! occluding junction GO:0070160 75 58 0,000 0,02754734 0,03026888 GO:0005923|tight junction, ! epidermal cell differentiation GO:0009913 66 58 0,000 0,02754734 0,03025977 ! hydrogen transport GO:0006818 61 58 0,000 0,02754734 0,03025066 ! receptor signaling protein serine/threonine kinase activity GO:0004702 64 58 0,000 0,02754734 0,03024155 ! lymphocyte mediated immunity GO:0002449 65 58 0,000 0,02754734 0,03023246 ! response to nutrient GO:0007584 68 58 0,000 0,02754734 0,03022336 ! large ribosomal subunit GO:0015934 64 58 0,000 0,02754734 0,03021428 ! regulation of tissue remodeling GO:0034103 66 58 0,000 0,02754734 0,0302052 ! ligand-dependent nuclear receptor activity GO:0004879 72 58 0,000 0,02754734 0,03019612 ! myosin complex GO:0016459 64 58 0,000 0,02754734 0,03018705 ! regulation of gene-specific transcription GO:0032583 69 59 0,000 0,02801632 0,03069175 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 62 59 0,000 0,02801632 0,03068253 GO:0051213|dioxygenase activity, ! muscle cell differentiation GO:0042692 77 59 0,000 0,02801632 0,03067333 ! actin filament organization GO:0007015 65 59 0,000 0,02801632 0,03066412 ! regulation of heart contraction GO:0008016 71 59 0,000 0,02801632 0,03065493 ! hexose catabolic process GO:0019320 64 59 0,000 0,02801632 0,03064573 ! cellular amino acid catabolic process GO:0009063 63 59 0,000 0,02801632 0,03063655 ! response to steroid hormone stimulus GO:0048545 74 59 0,000 0,02801632 0,03062737 ! cell projection assembly GO:0030031 79 59 0,000 0,02801632 0,03061819 ! regulation of cellular response to stress GO:0080135 79 59 0,000 0,02801632 0,03060902 ! appendage morphogenesis GO:0035107 68 59 0,000 0,02801632 0,03059986 GO:0035108|limb morphogenesis, ! fertilization GO:0009566 65 59 0,000 0,02801632 0,0305907 ! Rho guanyl-nucleotide exchange factor activity GO:0005089 69 59 0,000 0,02801632 0,03058154 ! adult behavior GO:0030534 72 59 0,000 0,02801632 0,0305724 ! organelle localization GO:0051640 70 59 0,000 0,02801632 0,03056325 ! positive regulation of secretion GO:0051047 66 60 0,000 0,02848509 0,03106536 ! molecular adaptor activity GO:0060090 73 60 0,000 0,02848509 0,03105607 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GO:0016701 63 60 0,000 0,02848509 0,03104679 ! phosphoinositide metabolic process GO:0030384 68 60 0,000 0,02848509 0,03103752 ! copper ion binding GO:0005507 85 60 0,000 0,02848509 0,03102825 ! positive regulation of lipase activity GO:0060193 68 60 0,000 0,02848509 0,03101899 ! activation of immune response GO:0002253 72 60 0,000 0,02848509 0,03100973 ! cell cycle checkpoint GO:0000075 91 60 0,000 0,02848509 0,03100048 ! regulation of caspase activity GO:0043281 78 60 0,000 0,02848509 0,03099124 ! appendage development GO:0048736 69 60 0,000 0,02848509 0,030982 GO:0060173|limb development, ! regulation of vesicle-mediated transport GO:0060627 69 60 0,000 0,02848509 0,03097276 ! secondary metabolic process GO:0019748 67 60 0,000 0,02848509 0,03096353 ! cellular hormone metabolic process GO:0034754 64 61 0,000 0,02895367 0,0314635 ! ear development GO:0043583 76 61 0,000 0,02895367 0,03145414 ! ATPase activity, coupled to transmembrane movement of ions GO:0042625 68 61 0,000 0,02895367 0,03144477 ! learning or memory GO:0007611 79 61 0,000 0,02895367 0,03143541 ! Ras GTPase binding GO:0017016 78 61 0,000 0,02895367 0,03142606 ! camera-type eye development GO:0043010 69 61 0,000 0,02895367 0,03141671 ! regulation of transcription factor activity GO:0051090 80 62 0,000 0,02942204 0,03191544 GO:0090046|regulation of transcription regulator activity, ! lung development GO:0030324 90 62 0,000 0,02942204 0,03190595 ! lysosomal membrane GO:0005765 69 62 0,000 0,02942204 0,03189647 ! membrane lipid metabolic process GO:0006643 76 62 0,000 0,02942204 0,03188699 ! nuclear pore GO:0005643 79 62 0,000 0,02942204 0,03187752 ! transmembrane receptor protein tyrosine kinase activity GO:0004714 77 62 0,000 0,02942204 0,03186806 ! skeletal system morphogenesis GO:0048705 83 62 0,000 0,02942204 0,0318586 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 77 62 0,000 0,02942204 0,03184915 ! chloride channel activity GO:0005254 72 62 0,000 0,02942204 0,0318397 ! cell soma GO:0043025 68 62 0,000 0,02942204 0,03183025 ! microtubule motor activity GO:0003777 94 62 0,000 0,02942204 0,03182082 ! intracellular receptor-mediated signaling pathway GO:0030522 80 62 0,000 0,02942204 0,03181139 ! focal adhesion GO:0005925 72 62 0,000 0,02942204 0,03180196 ! protein maturation by peptide bond cleavage GO:0051605 69 62 0,000 0,02942204 0,03179254 ! FAD binding GO:0050660 71 63 0,000 0,02989022 0,03228887 ! regulation of endopeptidase activity GO:0052548 81 63 0,000 0,02989022 0,03227931 ! urogenital system development GO:0001655 75 63 0,000 0,02989022 0,03226976 ! regulation of synaptic transmission GO:0050804 79 63 0,000 0,02989022 0,03226021 ! aminoglycan metabolic process GO:0006022 70 63 0,000 0,02989022 0,03225067 ! cAMP-mediated signaling GO:0019933 75 63 0,000 0,02989022 0,03224114 ! amine transmembrane transporter activity GO:0005275 69 63 0,000 0,02989022 0,03223161 ! regulation of immune effector process GO:0002697 81 63 0,000 0,02989022 0,03222208 ! respiratory tube development GO:0030323 92 64 0,000 0,03035819 0,03271689 ! intracellular protein transmembrane transport GO:0065002 83 64 0,000 0,03035819 0,03270723 ! tRNA processing GO:0008033 73 64 0,000 0,03035819 0,03269758 ! negative regulation of ligase activity GO:0051352 79 64 0,000 0,03035819 0,03268792 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! regulation of myeloid cell differentiation GO:0045637 77 64 0,000 0,03035819 0,03267828 ! adaptive immune response GO:0002250 70 64 0,000 0,03035819 0,03266864 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! transition metal ion transport GO:0000041 74 64 0,000 0,03035819 0,03265901 ! neurotransmitter transport GO:0006836 72 64 0,000 0,03035819 0,03264938 ! regulation of actin cytoskeleton organization GO:0032956 93 64 0,000 0,03035819 0,03263976 ! nuclear hormone receptor binding GO:0035257 79 64 0,000 0,03035819 0,03263014 ! N-acyltransferase activity GO:0016410 70 64 0,000 0,03035819 0,03262053 ! multicellular organism reproduction GO:0032504 71 65 0,000 0,03082597 0,03311341 GO:0048609|reproductive process in a multicellular organism, ! lymphocyte differentiation GO:0030098 93 65 0,000 0,03082597 0,03310366 ! regulation of cytokine biosynthetic process GO:0042035 84 65 0,000 0,03082597 0,03309392 ! activation of MAPK activity GO:0000187 74 65 0,000 0,03082597 0,03308418 ! gonad development GO:0008406 71 65 0,000 0,03082597 0,03307445 ! acetyltransferase activity GO:0016407 73 65 0,000 0,03082597 0,03306472 ! protein import into nucleus GO:0006606 73 66 0,000 0,03129354 0,03355639 ! developmental maturation GO:0021700 85 66 0,000 0,03129354 0,03354653 ! myeloid cell differentiation GO:0030099 78 66 0,000 0,03129354 0,03353667 ! tubulin binding GO:0015631 92 66 0,000 0,03129354 0,03352682 ! leukocyte mediated immunity GO:0002443 73 66 0,000 0,03129354 0,03351698 ! tube morphogenesis GO:0035239 84 66 0,000 0,03129354 0,03350714 ! cysteine-type endopeptidase activity GO:0004197 73 66 0,000 0,03129354 0,03349731 ! cell-substrate adherens junction GO:0005924 76 66 0,000 0,03129354 0,03348748 ! regulation of peptidase activity GO:0052547 86 67 0,000 0,03176091 0,03397766 ! endoplasmic reticulum lumen GO:0005788 78 67 0,000 0,03176091 0,03396769 ! glycerolipid biosynthetic process GO:0045017 81 67 0,000 0,03176091 0,03395774 ! nuclear import GO:0051170 74 67 0,000 0,03176091 0,03394779 ! response to peptide hormone stimulus GO:0043434 79 67 0,000 0,03176091 0,03393785 ! activation of protein kinase activity GO:0032147 83 67 0,000 0,03176091 0,03392791 ! regulation of actin filament-based process GO:0032970 96 67 0,000 0,03176091 0,03391798 ! chloride ion binding GO:0031404 79 67 0,000 0,03176091 0,03390805 ! humoral immune response GO:0006959 75 67 0,000 0,03176091 0,03389813 ! amine binding GO:0043176 77 67 0,000 0,03176091 0,03388821 ! female pregnancy GO:0007565 78 67 0,000 0,03176091 0,03387831 ! extrinsic to membrane GO:0019898 75 67 0,000 0,03176091 0,0338684 ! anion channel activity GO:0005253 77 67 0,000 0,03176091 0,0338585 ! regulation of homeostatic process GO:0032844 88 67 0,000 0,03176091 0,03384861 ! regulation of adenylate cyclase activity GO:0045761 81 68 0,000 0,03222808 0,03433646 ! amine catabolic process GO:0009310 73 68 0,000 0,03222808 0,03432644 ! monosaccharide catabolic process GO:0046365 73 68 0,000 0,03222808 0,03431642 ! cell-substrate junction GO:0030055 78 68 0,000 0,03222808 0,0343064 ! respiratory system development GO:0060541 96 68 0,000 0,03222808 0,0342964 ! mRNA transport GO:0051028 88 69 0,000 0,03269505 0,03478319 ! fatty acid biosynthetic process GO:0006633 76 69 0,000 0,03269505 0,03477305 ! small GTPase binding GO:0031267 86 69 0,000 0,03269505 0,03476291 ! regulation of transmission of nerve impulse GO:0051969 87 69 0,000 0,03269505 0,03475278 ! sarcomere GO:0030017 74 69 0,000 0,03269505 0,03474266 ! exocytosis GO:0006887 76 69 0,000 0,03269505 0,03473254 ! skeletal muscle tissue development GO:0007519 75 69 0,000 0,03269505 0,03472243 GO:0060538|skeletal muscle organ development, ! extracellular ligand-gated ion channel activity GO:0005230 82 69 0,000 0,03269505 0,03471233 ! Ras guanyl-nucleotide exchange factor activity GO:0005088 79 69 0,000 0,03269505 0,03470223 ! amine biosynthetic process GO:0009309 78 70 0,000 0,03316182 0,03518742 ! thiolester hydrolase activity GO:0016790 84 70 0,000 0,03316182 0,03517718 ! early endosome GO:0005769 104 70 0,000 0,03316182 0,03516696 ! regulation of cyclase activity GO:0031279 83 70 0,000 0,03316182 0,03515674 ! regulation of lipase activity GO:0060191 78 70 0,000 0,03316182 0,03514652 ! amino acid transport GO:0006865 76 70 0,000 0,03316182 0,03513632 ! hormone receptor binding GO:0051427 85 70 0,000 0,03316182 0,03512611 ! calcium channel activity GO:0005262 86 70 0,000 0,03316182 0,03511592 ! axon guidance GO:0007411 87 70 0,000 0,03316182 0,03510573 ! cell cortex GO:0005938 77 70 0,000 0,03316182 0,03509554 ! oxidoreductase activity, acting on NADH or NADPH GO:0016651 73 71 0,000 0,0336284 0,035579 ! mitochondrial outer membrane GO:0005741 81 71 0,000 0,0336284 0,03556868 ! protein localization in nucleus GO:0034504 78 71 0,000 0,0336284 0,03555837 ! lipoprotein metabolic process GO:0042157 76 71 0,000 0,0336284 0,03554807 ! pore complex GO:0046930 89 72 0,000 0,03409477 0,03603062 ! response to hypoxia GO:0001666 84 72 0,000 0,03409477 0,03602019 ! steroid biosynthetic process GO:0006694 83 72 0,000 0,03409477 0,03600976 ! regulation of MAPKKK cascade GO:0043408 82 72 0,000 0,03409477 0,03599934 ! regulation of lyase activity GO:0051339 85 72 0,000 0,03409477 0,03598892 ! acute inflammatory response GO:0002526 91 72 0,000 0,03409477 0,03597851 ! apical junction complex GO:0043296 90 72 0,000 0,03409477 0,0359681 ! phospholipase activity GO:0004620 99 72 0,000 0,03409477 0,03595771 ! membrane raft GO:0045121 81 72 0,000 0,03409477 0,03594731 ! regulation of neurological system process GO:0031644 91 72 0,000 0,03409477 0,03593693 ! structural constituent of cytoskeleton GO:0005200 78 72 0,000 0,03409477 0,03592655 ! elevation of cytosolic calcium ion concentration GO:0007204 87 73 0,000 0,03456094 0,03640725 GO:0051480|cytosolic calcium ion homeostasis, ! response to drug GO:0042493 94 73 0,000 0,03456094 0,03639674 ! protein transporter activity GO:0008565 80 73 0,000 0,03456094 0,03638623 ! regulation of cAMP biosynthetic process GO:0030817 86 73 0,000 0,03456094 0,03637573 ! exopeptidase activity GO:0008238 81 73 0,000 0,03456094 0,03636524 ! digestion GO:0007586 81 73 0,000 0,03456094 0,03635476 ! regulation of Rho protein signal transduction GO:0035023 88 73 0,000 0,03456094 0,03634428 ! cell-matrix adhesion GO:0007160 102 74 0,000 0,03502691 0,03682368 ! response to oxygen levels GO:0070482 86 74 0,000 0,03502691 0,03681307 ! potassium channel complex GO:0034705 84 74 0,000 0,03502691 0,03680246 GO:0008076|voltage-gated potassium channel complex, ! GTPase binding GO:0051020 91 74 0,000 0,03502691 0,03679187 ! hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 85 74 0,000 0,03502691 0,03678128 ! one-carbon metabolic process GO:0006730 84 74 0,000 0,03502691 0,03677069 ! blood coagulation GO:0007596 90 74 0,000 0,03502691 0,03676011 GO:0050817|coagulation, ! reproductive structure development GO:0048608 89 74 0,000 0,03502691 0,03674954 ! apicolateral plasma membrane GO:0016327 92 74 0,000 0,03502691 0,03673898 ! phosphoinositide-mediated signaling GO:0048015 92 74 0,000 0,03502691 0,03672842 ! cellular lipid catabolic process GO:0044242 99 74 0,000 0,03502691 0,03671786 ! ubiquitin ligase complex GO:0000151 91 74 0,000 0,03502691 0,03670731 ! cell projection part GO:0044463 80 74 0,000 0,03502691 0,03669677 ! meiosis GO:0007126 108 75 0,000 0,03549268 0,03717407 GO:0051327|M phase of meiotic cell cycle, ! regulation of DNA binding GO:0051101 94 75 0,000 0,03549268 0,0371634 ! carboxylic acid transmembrane transporter activity GO:0046943 85 75 0,000 0,03549268 0,03715274 ! regulation of cell cycle process GO:0010564 113 75 0,000 0,03549268 0,03714208 ! regulation of cAMP metabolic process GO:0030814 88 75 0,000 0,03549268 0,03713143 ! regulation of blood pressure GO:0008217 82 75 0,000 0,03549268 0,03712078 ! Ras GTPase activator activity GO:0005099 83 75 0,000 0,03549268 0,03711014 ! neuropeptide signaling pathway GO:0007218 85 76 0,000 0,03595825 0,03758616 ! defense response to bacterium GO:0042742 81 76 0,000 0,03595825 0,03757539 ! regulation of lipid metabolic process GO:0019216 98 76 0,000 0,03595825 0,03756463 ! cell leading edge GO:0031252 97 76 0,000 0,03595825 0,03755388 ! meiotic cell cycle GO:0051321 109 76 0,000 0,03595825 0,03754313 ! regulation of neuron differentiation GO:0045664 96 76 0,000 0,03595825 0,03753239 ! condensed chromosome GO:0000793 106 76 0,000 0,03595825 0,03752165 ! organic acid transmembrane transporter activity GO:0005342 86 76 0,000 0,03595825 0,03751092 ! development of primary sexual characteristics GO:0045137 86 76 0,000 0,03595825 0,0375002 ! cytosolic ribosome GO:0022626 82 76 0,000 0,03595825 0,03748948 ! serine-type endopeptidase inhibitor activity GO:0004867 93 76 0,000 0,03595825 0,03747877 ! S-adenosylmethionine-dependent methyltransferase activity GO:0008757 84 77 0,000 0,03642362 0,03795297 ! alcohol catabolic process GO:0046164 84 77 0,000 0,03642362 0,03794214 ! vacuolar membrane GO:0005774 86 77 0,000 0,03642362 0,03793131 ! G-protein-coupled receptor binding GO:0001664 87 77 0,000 0,03642362 0,03792048 ! regulation of Ras GTPase activity GO:0032318 88 77 0,000 0,03642362 0,03790966 ! establishment of RNA localization GO:0051236 97 77 0,000 0,03642362 0,03789885 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! myofibril GO:0030016 82 77 0,000 0,03642362 0,03788804 ! protein oligomerization GO:0051259 93 77 0,000 0,03642362 0,03787724 ! phosphoric diester hydrolase activity GO:0008081 99 78 0,000 0,03688879 0,03835004 ! endonuclease activity GO:0004519 111 78 0,000 0,03688879 0,03833912 ! cofactor biosynthetic process GO:0051188 93 78 0,000 0,03688879 0,0383282 ! inorganic anion transport GO:0015698 87 78 0,000 0,03688879 0,03831729 ! regulation of protein transport GO:0051223 85 78 0,000 0,03688879 0,03830638 ! regulation of nucleotide biosynthetic process GO:0030808 91 78 0,000 0,03688879 0,03829548 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! transmembrane receptor protein kinase activity GO:0019199 95 78 0,000 0,03688879 0,03828458 ! carboxylesterase activity GO:0004091 93 78 0,000 0,03688879 0,03827369 ! protein ubiquitination GO:0016567 95 78 0,000 0,03688879 0,03826281 ! extracellular matrix structural constituent GO:0005201 96 78 0,000 0,03688879 0,03825194 ! contractile fiber part GO:0044449 83 78 0,000 0,03688879 0,03824106 ! RNA localization GO:0006403 99 79 0,000 0,03735376 0,03871208 ! positive regulation of MAP kinase activity GO:0043406 89 79 0,000 0,03735376 0,03870109 ! vitamin metabolic process GO:0006766 86 79 0,000 0,03735376 0,0386901 ! T cell activation GO:0042110 120 79 0,000 0,03735376 0,03867912 ! cellular response to hormone stimulus GO:0032870 94 79 0,000 0,03735376 0,03866814 ! phosphoinositide binding GO:0035091 99 79 0,000 0,03735376 0,03865717 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 88 80 0,000 0,03781853 0,03912706 ! eye development GO:0001654 93 80 0,000 0,03781853 0,03911597 ! ATP biosynthetic process GO:0006754 89 80 0,000 0,03781853 0,03910488 ! rhythmic process GO:0048511 90 80 0,000 0,03781853 0,0390938 ! regulation of catabolic process GO:0009894 87 80 0,000 0,03781853 0,03908272 ! SH3 domain binding GO:0017124 95 80 0,000 0,03781853 0,03907165 ! hemostasis GO:0007599 96 80 0,000 0,03781853 0,03906059 ! chromosome, centromeric region GO:0000775 119 80 0,000 0,03781853 0,03904954 ! regulation of cyclic nucleotide metabolic process GO:0030799 93 80 0,000 0,03781853 0,03903849 ! cell-substrate adhesion GO:0031589 109 80 0,000 0,03781853 0,03902744 ! rRNA processing GO:0006364 84 80 0,000 0,03781853 0,03901641 ! cholesterol metabolic process GO:0008203 91 81 0,000 0,03828311 0,03948453 ! vacuolar part GO:0044437 91 81 0,000 0,03828311 0,03947337 ! ossification GO:0001503 111 82 0,000 0,03874748 0,03994089 ! mitochondrion organization GO:0007005 104 82 0,000 0,03874748 0,03992961 ! biogenic amine metabolic process GO:0006576 99 82 0,000 0,03874748 0,03991833 ! forebrain development GO:0030900 93 82 0,000 0,03874748 0,03990706 ! external side of plasma membrane GO:0009897 105 82 0,000 0,03874748 0,0398958 ! cellular respiration GO:0045333 85 82 0,000 0,03874748 0,03988454 ! heparin binding GO:0008201 108 82 0,000 0,03874748 0,03987329 ! microtubule-based movement GO:0007018 119 83 0,000 0,03921165 0,04033957 ! nuclear speck GO:0016607 99 83 0,000 0,03921165 0,0403282 ! rRNA metabolic process GO:0016072 88 83 0,000 0,03921165 0,04031683 ! ATP-dependent helicase activity GO:0008026 107 83 0,000 0,03921165 0,04030547 GO:0070035|purine NTP-dependent helicase activity, ! regulation of cell adhesion GO:0030155 98 83 0,000 0,03921165 0,04029412 ! regulation of T cell activation GO:0050863 104 83 0,000 0,03921165 0,04028277 ! regulation of establishment of protein localization GO:0070201 90 83 0,000 0,03921165 0,04027143 ! oxidative phosphorylation GO:0006119 85 83 0,000 0,03921165 0,04026009 ! contractile fiber GO:0043292 88 83 0,000 0,03921165 0,04024877 ! bone development GO:0060348 112 83 0,000 0,03921165 0,04023744 ! regulation of nucleotide metabolic process GO:0006140 96 83 0,000 0,03921165 0,04022613 ! regulation of membrane potential GO:0042391 98 83 0,000 0,03921165 0,04021482 ! cilium GO:0005929 88 83 0,000 0,03921165 0,04020352 ! regulation of DNA metabolic process GO:0051052 139 84 0,000 0,03967563 0,0406678 ! regulation of defense response GO:0031347 98 84 0,000 0,03967563 0,04065637 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 94 84 0,000 0,03967563 0,04064496 ! nitrogen compound catabolic process GO:0044270 91 84 0,000 0,03967563 0,04063355 ! DNA recombination GO:0006310 147 84 0,000 0,03967563 0,04062214 ! phospholipid biosynthetic process GO:0008654 101 85 0,000 0,0401394 0,04108545 ! protein modification by small protein conjugation GO:0032446 103 85 0,000 0,0401394 0,04107393 ! monooxygenase activity GO:0004497 92 85 0,000 0,0401394 0,04106241 ! hydrogen ion transmembrane transporter activity GO:0015078 88 85 0,000 0,0401394 0,0410509 ! protein binding, bridging GO:0030674 104 85 0,000 0,0401394 0,04103939 ! negative regulation of transport GO:0051051 98 86 0,000 0,04060298 0,04150173 ! clathrin-coated vesicle GO:0030136 100 86 0,000 0,04060298 0,0414901 ! Golgi vesicle transport GO:0048193 98 86 0,000 0,04060298 0,04147849 ! lipase activity GO:0016298 114 86 0,000 0,04060298 0,04146687 ! voltage-gated potassium channel activity GO:0005249 105 86 0,000 0,04060298 0,04145527 ! adherens junction GO:0005912 100 86 0,000 0,04060298 0,04144367 ! microtubule cytoskeleton organization GO:0000226 113 87 0,000 0,04106636 0,04190492 ! leukocyte differentiation GO:0002521 118 87 0,000 0,04106636 0,0418932 ! pigment granule GO:0048770 101 87 0,000 0,04106636 0,04188149 GO:0042470|melanosome, ! regulation of cell morphogenesis GO:0022604 100 87 0,000 0,04106636 0,04186978 ! organelle outer membrane GO:0031968 102 88 0,000 0,04152954 0,04233019 ! carbohydrate biosynthetic process GO:0016051 95 88 0,000 0,04152954 0,04231837 ! growth factor binding GO:0019838 102 88 0,000 0,04152954 0,04230655 ! protein processing GO:0016485 100 88 0,000 0,04152954 0,04229474 ! protein tyrosine phosphatase activity GO:0004725 109 89 0,000 0,04199252 0,04275431 ! gland development GO:0048732 108 89 0,000 0,04199252 0,04274238 ! ATP metabolic process GO:0046034 100 90 0,000 0,0424553 0,04320137 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 101 90 0,000 0,0424553 0,04318933 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! peroxisome GO:0005777 100 90 0,000 0,0424553 0,04317728 GO:0042579|microbody, ! glycerophospholipid metabolic process GO:0006650 109 90 0,000 0,0424553 0,04316525 ! sterol metabolic process GO:0016125 102 90 0,000 0,0424553 0,04315322 ! negative regulation of multicellular organismal process GO:0051241 102 90 0,000 0,0424553 0,0431412 ! anion binding GO:0043168 104 90 0,000 0,0424553 0,04312919 ! amine transport GO:0015837 97 90 0,000 0,0424553 0,04311718 ! response to virus GO:0009615 109 90 0,000 0,0424553 0,04310518 ! outer membrane GO:0019867 104 90 0,000 0,0424553 0,04309319 ! extracellular matrix part GO:0044420 111 90 0,000 0,0424553 0,0430812 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 108 91 0,000 0,04291788 0,04353849 ! ribonucleoside triphosphate biosynthetic process GO:0009201 102 91 0,000 0,04291788 0,04352639 GO:0009142|nucleoside triphosphate biosynthetic process, ! positive regulation of immune response GO:0050778 104 91 0,000 0,04291788 0,04351429 ! sulfur metabolic process GO:0006790 98 91 0,000 0,04291788 0,0435022 ! sex differentiation GO:0007548 103 91 0,000 0,04291788 0,04349012 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 112 91 0,000 0,04291788 0,04347804 ! hormone metabolic process GO:0042445 107 91 0,000 0,04291788 0,04346597 ! regulation of protein localization GO:0032880 99 91 0,000 0,04291788 0,0434539 ! detection of stimulus GO:0051606 100 91 0,000 0,04291788 0,04344185 ! anatomical structure homeostasis GO:0060249 121 92 0,000 0,04338026 0,0438977 ! regulation of cellular component biogenesis GO:0044087 115 92 0,000 0,04338026 0,04388552 ! carboxylic acid catabolic process GO:0046395 100 92 0,000 0,04338026 0,04387336 GO:0016054|organic acid catabolic process, ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 111 92 0,000 0,04338026 0,0438612 ! regulation of GTPase activity GO:0043087 105 92 0,000 0,04338026 0,04384904 ! extracellular structure organization GO:0043062 119 92 0,000 0,04338026 0,0438369 ! protein import GO:0017038 102 93 0,000 0,04384245 0,04429168 ! neurotransmitter receptor activity GO:0030594 104 93 0,000 0,04384245 0,04427941 ! response to nutrient levels GO:0031667 105 93 0,000 0,04384245 0,04426716 ! Ras protein signal transduction GO:0007265 118 93 0,000 0,04384245 0,04425491 ! protein modification by small protein conjugation or removal GO:0070647 112 93 0,000 0,04384245 0,04424267 ! ATPase activity, coupled to transmembrane movement of substances GO:0042626 102 94 0,000 0,04430443 0,04469651 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 104 94 0,000 0,04430443 0,04468415 ! morphogenesis of an epithelium GO:0002009 113 94 0,000 0,04430443 0,0446718 GO:0060429|epithelium development, ! anchoring junction GO:0070161 108 94 0,000 0,04430443 0,04465946 ! neurotransmitter binding GO:0042165 105 94 0,000 0,04430443 0,04464712 ! homophilic cell adhesion GO:0007156 107 95 0,000 0,04476622 0,04510002 ! ATPase activity, coupled to movement of substances GO:0043492 104 95 0,000 0,04476622 0,04508757 ! anterior/posterior pattern formation GO:0009952 109 95 0,000 0,04476622 0,04507512 ! protein localization in organelle GO:0033365 104 95 0,000 0,04476622 0,04506269 ! Wnt receptor signaling pathway GO:0016055 121 95 0,000 0,04476622 0,04505025 ! immune effector process GO:0002252 110 95 0,000 0,04476622 0,04503783 ! apical plasma membrane GO:0016324 105 95 0,000 0,04476622 0,04502541 ! translational elongation GO:0006414 104 96 0,000 0,04522781 0,04547714 ! hydrolase activity, acting on glycosyl bonds GO:0016798 109 96 0,000 0,04522781 0,0454646 ! carbohydrate catabolic process GO:0016052 116 96 0,000 0,04522781 0,04545208 ! receptor complex GO:0043235 131 96 0,000 0,04522781 0,04543956 ! regulation of response to external stimulus GO:0032101 109 96 0,000 0,04522781 0,04542705 ! monovalent inorganic cation transmembrane transporter activity GO:0015077 100 96 0,000 0,04522781 0,04541455 ! electron transport chain GO:0022900 104 97 0,000 0,0456892 0,04586522 ! metalloendopeptidase activity GO:0004222 126 97 0,000 0,0456892 0,0458526 ! perinuclear region of cytoplasm GO:0048471 125 97 0,000 0,0456892 0,04583999 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016820 105 97 0,000 0,0456892 0,04582739 ! carboxylic acid binding GO:0031406 108 97 0,000 0,0456892 0,04581479 ! protein maturation GO:0051604 109 97 0,000 0,0456892 0,0458022 ! intermediate filament GO:0005882 102 98 0,000 0,04615039 0,04625182 GO:0045111|intermediate filament cytoskeleton, ! UDP-glycosyltransferase activity GO:0008194 120 98 0,000 0,04615039 0,04623912 ! cell fate commitment GO:0045165 118 98 0,000 0,04615039 0,04622642 ! hormone activity GO:0005179 113 99 0,000 0,04661139 0,04667536 ! solute:cation symporter activity GO:0015294 110 99 0,000 0,04661139 0,04666255 ! unfolded protein binding GO:0051082 118 100 0,000 0,04707219 0,04711093 ! regulation of neurogenesis GO:0050767 123 100 0,000 0,04707219 0,04709801 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016810 105 100 0,000 0,04707219 0,04708509 ! peptide receptor activity, G-protein coupled GO:0008528 107 100 0,000 0,04707219 0,04707219