pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a1/out-0.05-06-0.01-300-run-a1//th1-pval-1e-02-02-th2-pval-1e-01-11-th3-pval-1e-01-01-run-a1/go_data/5339-6-real-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 1,948E-09 4,48E-06 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 2,000 2,172E-08 2,498E-05 ! nucleoside diphosphate metabolic process GO:0009132 8 7 2,000 3,799E-08 2,912E-05 ! deoxyribonucleotide metabolic process GO:0009262 27 21 2,000 1,43E-06 8,221E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 1,048E-05 4,822E-03 ! negative regulation of protein ubiquitination GO:0031397 7 5 1,000 1,117E-05 4,282E-03 ! positive regulation of Rho GTPase activity GO:0032321 9 5 1,000 1,117E-05 3,67E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 1,307E-05 3,757E-03 ! response to UV GO:0009411 75 46 2,000 1,604E-05 4,099E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 2,343E-05 5,388E-03 ! regulation of focal adhesion formation GO:0051893 17 7 1,000 2,343E-05 4,898E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 3,069E-05 5,882E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 3,121E-05 5,522E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 3,121E-05 5,128E-03 ! keratinocyte proliferation GO:0043616 12 8 1,000 3,121E-05 4,786E-03 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 3,121E-05 4,487E-03 ! negative regulation of kinase activity GO:0033673 100 58 2,000 3,234E-05 4,375E-03 ! negative regulation of transferase activity GO:0051348 105 61 2,000 3,764E-05 4,81E-03 ! positive regulation of GTPase activity GO:0043547 21 9 1,000 4,011E-05 4,855E-03 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 1,000 4,011E-05 4,612E-03 ! regulation of stress fiber formation GO:0051492 20 9 1,000 4,011E-05 4,392E-03 ! protein oligomerization GO:0051259 100 65 2,000 4,556E-05 4,763E-03 ! regulation of B cell proliferation GO:0030888 15 10 1,000 5,01E-05 5,01E-03 ! regulation of phosphatase activity GO:0010921 21 10 1,000 5,01E-05 4,801E-03 ! regulation of actin filament bundle formation GO:0032231 21 10 1,000 5,01E-05 4,609E-03 ! regulation of Rho GTPase activity GO:0032319 18 11 1,000 6,119E-05 5,413E-03 ! positive regulation of cell growth GO:0030307 16 12 1,000 7,338E-05 6,251E-03 ! negative regulation of caspase activity GO:0043154 20 14 1,000 1,01E-04 8,3E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,01E-04 8,014E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 1,052E-04 8,066E-03 ! interphase GO:0051325 159 88 2,000 1,127E-04 8,359E-03 ! regulation of protein ubiquitination GO:0031396 19 15 1,000 1,165E-04 8,375E-03 ! positive regulation of cell size GO:0045793 20 15 1,000 1,165E-04 8,121E-03 ! skin development GO:0043588 25 15 1,000 1,165E-04 7,882E-03 ! cellular response to unfolded protein GO:0034620 19 16 1,000 1,331E-04 8,745E-03 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of dephosphorylation GO:0035303 33 16 1,000 1,331E-04 8,502E-03 ! negative regulation of translation GO:0017148 22 16 1,000 1,331E-04 8,272E-03 ! response to light stimulus GO:0009416 153 96 2,000 1,459E-04 8,83E-03 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 1,507E-04 8,889E-03 ! regulation of translation GO:0006417 151 100 2,000 1,646E-04 9,467E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 1,695E-04 9,506E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 1,893E-04 0,01036469 ! positive regulation of B cell activation GO:0050871 31 20 1,000 2,102E-04 0,01124122 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 2,321E-04 0,01213426 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 2,321E-04 0,01186461 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 2,321E-04 0,01160668 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 2,552E-04 0,01248761 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 2,552E-04 0,01222745 GO:0010810|regulation of cell-substrate adhesion, ! positive regulation of cell adhesion GO:0045785 37 23 1,000 2,793E-04 0,01311017 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 2,793E-04 0,01284796 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 2,793E-04 0,01259604 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 2,793E-04 0,01235381 ! fat cell differentiation GO:0045444 37 24 1,000 3,045E-04 0,01321404 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 3,308E-04 0,01408797 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of protein modification process GO:0031400 50 26 1,000 3,581E-04 0,01497477 ! regulation of B cell activation GO:0050864 42 28 1,000 4,159E-04 0,01708364 ! spindle organization GO:0007051 37 30 1,000 4,781E-04 0,01928982 ! meiosis I GO:0007127 52 32 1,000 5,444E-04 0,02158762 ! RNA export from nucleus GO:0006405 44 33 1,000 5,791E-04 0,02257625 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 5,791E-04 0,02219997 ! keratinocyte differentiation GO:0030216 47 35 1,000 6,518E-04 0,02457504 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 6,518E-04 0,02417867 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! response to calcium ion GO:0051592 58 40 1,000 8,517E-04 0,03109244 ! epidermal cell differentiation GO:0009913 53 40 1,000 8,517E-04 0,03060662 ! response to insulin stimulus GO:0032868 63 43 1,000 9,84E-04 0,03482021 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 1,03E-03 0,03590235 ! positive regulation of cell cycle GO:0045787 77 45 1,000 1,077E-03 0,03698749 ! regulation of translational initiation GO:0006446 64 45 1,000 1,077E-03 0,03644356 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 1,175E-03 0,03916596 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! nuclear export GO:0051168 69 48 1,000 1,225E-03 0,04025891 ! positive regulation of growth GO:0045927 67 50 1,000 1,329E-03 0,04304933 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 1,664E-03 0,05316063 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 1,724E-03 0,05430388 ! meiosis GO:0007126 96 61 1,000 1,971E-03 0,0612655 GO:0051327|M phase of meiotic cell cycle, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 1,971E-03 0,06044863 ! negative regulation of cell growth GO:0030308 106 62 1,000 2,036E-03 0,06160182 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 2,036E-03 0,0608018 ! meiotic cell cycle GO:0051321 97 62 1,000 2,036E-03 0,06002229 ! negative regulation of cell size GO:0045792 108 64 1,000 2,167E-03 0,06309821 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 2,167E-03 0,06230948 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 2,167E-03 0,06154023 ! regulation of caspase activity GO:0043281 97 65 1,000 2,235E-03 0,062679 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 2,235E-03 0,06192383 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 2,235E-03 0,06118665 ! regulation of actin filament-based process GO:0032970 99 66 1,000 2,303E-03 0,06231606 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 2,303E-03 0,06159145 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 2,372E-03 0,06271626 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 2,443E-03 0,06384116 ! positive regulation of ligase activity GO:0051351 99 69 1,000 2,514E-03 0,06496609 ! response to metal ion GO:0010038 103 70 1,000 2,586E-03 0,06609102 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 2,586E-03 0,06536474 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 2,659E-03 0,06648527 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 2,659E-03 0,06577038 ! regulation of peptidase activity GO:0052547 106 72 1,000 2,734E-03 0,06688658 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 2,734E-03 0,06618251 GO:0045937|positive regulation of phosphate metabolic process, ! mitochondrion organization GO:0007005 104 73 1,000 2,809E-03 0,06729444 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 2,885E-03 0,06840645 ! response to inorganic substance GO:0010035 115 75 1,000 2,962E-03 0,06951847 ! negative regulation of growth GO:0045926 123 75 1,000 2,962E-03 0,06881626 ! regulation of ligase activity GO:0051340 114 75 1,000 2,962E-03 0,0681281 ! response to unfolded protein GO:0006986 99 76 1,000 3,04E-03 0,06923185 ! positive regulation of protein modification process GO:0031401 107 78 1,000 3,199E-03 0,07213996 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 3,362E-03 0,07507735 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 1,000 3,362E-03 0,07435545 ! response to protein stimulus GO:0051789 111 81 1,000 3,445E-03 0,07546298 ! positive regulation of cell activation GO:0050867 120 81 1,000 3,445E-03 0,07475107 GO:0002696|positive regulation of leukocyte activation, ! regulation of cell adhesion GO:0030155 159 83 1,000 3,614E-03 0,07767743 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 3,699E-03 0,07878427 ! cell cycle arrest GO:0007050 150 86 1,000 3,874E-03 0,08174012 ! establishment of RNA localization GO:0051236 128 88 1,000 4,052E-03 0,08472121 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! RNA localization GO:0006403 135 91 1,000 4,326E-03 0,08963997 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 4,514E-03 0,09268985 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 4,802E-03 0,09773584 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 4,802E-03 0,09687851 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 5,098E-03 0,10196686 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 5,423E-03 0,10752462 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 5,423E-03 0,1066056 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 5,423E-03 0,10570217 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 5,423E-03 0,10481391 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 5,423E-03 0,10394046 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 5,423E-03 0,10308145 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 5,423E-03 0,10223652 ! sleep GO:0030431 11 5 0,000 5,423E-03 0,10140533 ! negative regulation of bone resorption GO:0045779 10 5 0,000 5,423E-03 0,10058755 ! nucleotide-sugar transport GO:0015780 8 5 0,000 5,423E-03 0,09978285 ! regulation of interferon-beta production GO:0032648 5 5 0,000 5,423E-03 0,09899092 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 5,423E-03 0,09821146 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 5,423E-03 0,09744419 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 5,423E-03 0,0966888 ! tongue development GO:0043586 6 5 0,000 5,423E-03 0,09594504 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 5,423E-03 0,09521264 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 5,423E-03 0,09449133 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 5,423E-03 0,09378087 ! cobalt ion transport GO:0006824 9 5 0,000 5,423E-03 0,09308101 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 5,423E-03 0,09239152 ! SMAD protein complex assembly GO:0007183 9 5 0,000 5,423E-03 0,09171217 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 5,423E-03 0,09104274 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 5,423E-03 0,09038301 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 5,423E-03 0,08973277 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 5,423E-03 0,08909183 ! embryonic camera-type eye development GO:0031076 8 5 0,000 5,423E-03 0,08845997 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 5,423E-03 0,08783701 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 5,423E-03 0,08722277 ! adaptation of signaling pathway GO:0022401 7 5 0,000 5,423E-03 0,08661705 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 5,423E-03 0,08601969 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 5,423E-03 0,08543052 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 5,423E-03 0,08484936 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 5,423E-03 0,08427605 ! positive regulation of histone modification GO:0031058 5 5 0,000 5,423E-03 0,08371044 ! malate metabolic process GO:0006108 7 5 0,000 5,423E-03 0,08315237 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 5,423E-03 0,08260169 ! behavioral response to pain GO:0048266 7 5 0,000 5,423E-03 0,08205826 ! clathrin coat assembly GO:0048268 11 5 0,000 5,423E-03 0,08152193 ! phototransduction, visible light GO:0007603 6 5 0,000 5,423E-03 0,08099257 ! regulation of dopamine uptake GO:0051584 9 5 0,000 5,423E-03 0,08047004 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 5,423E-03 0,0799542 ! mating behavior GO:0007617 6 5 0,000 5,423E-03 0,07944494 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 5,423E-03 0,07894212 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 5,423E-03 0,07844563 ! rhythmic behavior GO:0007622 12 5 0,000 5,423E-03 0,07795535 ! copulation GO:0007620 7 5 0,000 5,423E-03 0,07747115 ! glial cell fate commitment GO:0021781 12 5 0,000 5,423E-03 0,07699294 ! protein maturation by protein folding GO:0022417 12 5 0,000 5,423E-03 0,07652059 ! embryonic hemopoiesis GO:0035162 10 5 0,000 5,423E-03 0,076054 ! regulation of potassium ion transport GO:0043266 9 5 0,000 5,423E-03 0,07559306 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 5,423E-03 0,07513768 ! apoptotic cell clearance GO:0043277 13 5 0,000 5,423E-03 0,07468776 ! lipoprotein particle clearance GO:0034381 9 5 0,000 5,423E-03 0,07424319 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 5,423E-03 0,07380388 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 5,423E-03 0,07336974 ! response to protozoan GO:0001562 9 5 0,000 5,423E-03 0,07294068 ! positive regulation of glycolysis GO:0045821 11 5 0,000 5,423E-03 0,0725166 ! lymph vessel development GO:0001945 7 5 0,000 5,423E-03 0,07209743 ! endochondral ossification GO:0001958 12 5 0,000 5,423E-03 0,07168308 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 5,423E-03 0,07127346 ! parathyroid gland development GO:0060017 8 5 0,000 5,423E-03 0,0708685 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 5,423E-03 0,07046811 ! anagen GO:0042640 6 5 0,000 5,423E-03 0,07007222 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 5,423E-03 0,06968076 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 5,423E-03 0,06929364 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 5,423E-03 0,0689108 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 5,423E-03 0,06853217 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 5,423E-03 0,06815768 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 5,423E-03 0,06778726 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 5,423E-03 0,06742084 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 5,423E-03 0,06705836 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 5,423E-03 0,06669976 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 5,423E-03 0,06634498 ! cardiac muscle fiber development GO:0048739 7 5 0,000 5,423E-03 0,06599395 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 5,423E-03 0,06564661 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 5,423E-03 0,06530291 ! neutrophil mediated immunity GO:0002446 6 5 0,000 5,423E-03 0,06496279 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 5,423E-03 0,0646262 ! ovulation GO:0030728 6 5 0,000 5,423E-03 0,06429307 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 5,423E-03 0,06396336 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 5,423E-03 0,06363702 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 5,423E-03 0,06331399 ! response to pH GO:0009268 9 5 0,000 5,423E-03 0,06299422 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 5,423E-03 0,06267767 ! proline biosynthetic process GO:0006561 6 5 0,000 5,423E-03 0,06236428 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 5,423E-03 0,06205401 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 5,423E-03 0,06174681 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 5,423E-03 0,06144264 ! polyol catabolic process GO:0046174 7 5 0,000 5,423E-03 0,06114145 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 5,423E-03 0,0608432 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 5,423E-03 0,06054784 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 5,423E-03 0,06025534 ! sister chromatid cohesion GO:0007062 9 5 0,000 5,423E-03 0,05996565 ! nerve growth factor processing GO:0032455 7 5 0,000 5,423E-03 0,05967874 ! urea metabolic process GO:0019627 6 5 0,000 5,423E-03 0,05939455 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 5,423E-03 0,05911306 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 5,423E-03 0,05883422 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 5,423E-03 0,05855801 ! neutrophil activation GO:0042119 5 5 0,000 5,423E-03 0,05828437 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 5,423E-03 0,05801328 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 5,423E-03 0,0577447 ! response to food GO:0032094 5 5 0,000 5,423E-03 0,0574786 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 5,423E-03 0,05721493 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 5,423E-03 0,05695368 ! paraxial mesoderm development GO:0048339 9 5 0,000 5,423E-03 0,0566948 ! forebrain neuron development GO:0021884 7 5 0,000 5,423E-03 0,05643826 ! melanosome organization GO:0032438 7 5 0,000 5,423E-03 0,05618403 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 5,423E-03 0,05593209 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 5,423E-03 0,05568239 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 5,423E-03 0,05543491 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 5,423E-03 0,05518963 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 5,423E-03 0,0549465 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 5,423E-03 0,05470551 ! nucleoside transport GO:0015858 6 5 0,000 5,423E-03 0,05446662 ! nucleoside salvage GO:0043174 7 5 0,000 5,423E-03 0,05422981 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 5,423E-03 0,05399505 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 5,423E-03 0,05376231 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 5,423E-03 0,05353157 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 5,423E-03 0,0533028 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 5,423E-03 0,05307598 ! early endosome to late endosome transport GO:0045022 11 5 0,000 5,423E-03 0,05285108 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 5,423E-03 0,05262808 ! depyrimidination GO:0045008 8 5 0,000 5,423E-03 0,05240696 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 5,423E-03 0,05218768 ! 5S class rRNA transcription GO:0042791 8 5 0,000 5,423E-03 0,05197023 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 5,423E-03 0,05175459 ! regulation of centrosome cycle GO:0046605 7 5 0,000 5,423E-03 0,05154073 ! neuronal ion channel clustering GO:0045161 7 5 0,000 5,423E-03 0,05132862 ! sodium ion homeostasis GO:0055078 6 5 0,000 5,423E-03 0,05111826 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 5,423E-03 0,05090962 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 5,423E-03 0,05070267 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 5,423E-03 0,05049739 ! monocyte differentiation GO:0030224 8 5 0,000 5,423E-03 0,05029377 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 5,423E-03 0,05009179 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 5,423E-03 0,04989142 ! centrosome duplication GO:0051298 5 5 0,000 5,423E-03 0,04969265 ! response to UV-C GO:0010225 6 5 0,000 5,423E-03 0,04949546 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 5,423E-03 0,04929982 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 5,423E-03 0,04910573 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 5,423E-03 0,04891316 ! regulation of dendrite development GO:0050773 12 5 0,000 5,423E-03 0,04872209 ! peptidyl-arginine modification GO:0018195 7 5 0,000 5,423E-03 0,04853251 ! positive regulation of organ growth GO:0046622 6 5 0,000 5,423E-03 0,0483444 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 5,423E-03 0,04815774 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 5,423E-03 0,04797252 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 5,423E-03 0,04778872 ! regulation of dopamine secretion GO:0014059 12 5 0,000 5,423E-03 0,04760632 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 5,423E-03 0,04742531 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 5,423E-03 0,04724567 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 5,423E-03 0,04706738 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 5,423E-03 0,04689043 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 5,423E-03 0,04671482 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 5,423E-03 0,04654051 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 5,423E-03 0,04636749 ! neural tube patterning GO:0021532 6 5 0,000 5,423E-03 0,04619576 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 5,423E-03 0,0460253 ! histone demethylation GO:0016577 9 5 0,000 5,423E-03 0,04585609 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 5,423E-03 0,04568812 ! regulation of sterol transport GO:0032371 7 5 0,000 5,423E-03 0,04552137 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 5,423E-03 0,04535584 ! enteric nervous system development GO:0048484 8 5 0,000 5,423E-03 0,04519151 ! establishment of planar polarity GO:0001736 6 5 0,000 5,423E-03 0,04502836 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 5,423E-03 0,04486639 ! muscle cell proliferation GO:0033002 8 5 0,000 5,423E-03 0,04470558 ! transcription termination GO:0006353 8 5 0,000 5,423E-03 0,04454591 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 5,423E-03 0,04438739 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 5,423E-03 0,04422998 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 5,423E-03 0,0440737 ! regulation of respiratory burst GO:0060263 8 5 0,000 5,423E-03 0,04391851 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 5,423E-03 0,04376441 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 5,423E-03 0,04361138 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 5,423E-03 0,04345943 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 5,423E-03 0,04330853 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 5,423E-03 0,04315867 ! apical protein localization GO:0045176 6 5 0,000 5,423E-03 0,04300985 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 5,423E-03 0,04286205 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 5,423E-03 0,04271526 ! galactolipid metabolic process GO:0019374 7 5 0,000 5,423E-03 0,04256947 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 5,423E-03 0,04242468 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 5,423E-03 0,04228087 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 5,423E-03 0,04213803 ! triglyceride catabolic process GO:0019433 6 5 0,000 5,423E-03 0,04199615 ! glial cell migration GO:0008347 10 5 0,000 5,423E-03 0,04185522 ! determination of adult lifespan GO:0008340 8 5 0,000 5,423E-03 0,04171524 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 5,423E-03 0,04157619 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 5,423E-03 0,04143806 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 5,423E-03 0,04130085 ! somatic stem cell maintenance GO:0035019 13 5 0,000 5,423E-03 0,04116454 ! cerebellar cortex formation GO:0021697 6 5 0,000 5,423E-03 0,04102913 ! neural plate development GO:0001840 6 5 0,000 5,423E-03 0,04089461 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 5,423E-03 0,04076097 ! regulation of sensory perception GO:0051931 6 5 0,000 5,423E-03 0,04062819 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 5,423E-03 0,04049628 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 5,423E-03 0,04036523 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 5,423E-03 0,04023502 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 5,423E-03 0,04010565 ! sensory cilium assembly GO:0035058 6 5 0,000 5,423E-03 0,0399771 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 5,423E-03 0,03984938 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 5,423E-03 0,03972247 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 5,423E-03 0,03959637 ! spindle assembly GO:0051225 5 5 0,000 5,423E-03 0,03947106 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 5,423E-03 0,03934655 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 5,423E-03 0,03922282 ! protein amino acid prenylation GO:0018346 9 5 0,000 5,423E-03 0,03909986 ! organ regeneration GO:0031100 7 5 0,000 5,423E-03 0,03897767 ! NAD biosynthetic process GO:0009435 7 5 0,000 5,423E-03 0,03885625 ! carnitine metabolic process GO:0009437 5 5 0,000 5,423E-03 0,03873558 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 5,423E-03 0,03861565 ! cellular anion homeostasis GO:0030002 6 5 0,000 5,423E-03 0,03849647 GO:0055081|anion homeostasis, ! tRNA transcription GO:0009304 11 6 0,000 6,504E-03 0,04602992 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 6,504E-03 0,04588873 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 6,504E-03 0,04574839 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 6,504E-03 0,04560892 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 6,504E-03 0,04547029 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 6,504E-03 0,0453325 ! regulation of helicase activity GO:0051095 11 6 0,000 6,504E-03 0,04519554 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 6,504E-03 0,04505941 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 6,504E-03 0,0449241 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 6,504E-03 0,0447896 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 6,504E-03 0,0446559 ! positive regulation of axon extension GO:0045773 8 6 0,000 6,504E-03 0,04452299 ! prostate gland development GO:0030850 9 6 0,000 6,504E-03 0,04439088 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 6,504E-03 0,04425954 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 6,504E-03 0,04412898 ! forebrain neuron differentiation GO:0021879 9 6 0,000 6,504E-03 0,04399919 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 6,504E-03 0,04387016 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 6,504E-03 0,04374189 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 6,504E-03 0,04361436 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 6,504E-03 0,04348757 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 6,504E-03 0,04336152 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 6,504E-03 0,0432362 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 6,504E-03 0,0431116 ! neuron adhesion GO:0007158 9 6 0,000 6,504E-03 0,04298772 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 6,504E-03 0,04286454 ! establishment of tissue polarity GO:0007164 7 6 0,000 6,504E-03 0,04274207 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 6,504E-03 0,0426203 ! signal peptide processing GO:0006465 8 6 0,000 6,504E-03 0,04249922 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 6,504E-03 0,04237882 ! mRNA stabilization GO:0048255 15 6 0,000 6,504E-03 0,04225911 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 6,504E-03 0,04214007 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 6,504E-03 0,0420217 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 6,504E-03 0,04190399 ! opsonization GO:0008228 8 6 0,000 6,504E-03 0,04178694 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 6,504E-03 0,04167054 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 6,504E-03 0,04155479 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 6,504E-03 0,04143968 ! protein amino acid dealkylation GO:0008214 11 6 0,000 6,504E-03 0,04132521 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 6,504E-03 0,04121136 ! photoreceptor cell development GO:0042461 10 6 0,000 6,504E-03 0,04109815 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 6,504E-03 0,04098555 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 6,504E-03 0,04087357 ! mechanosensory behavior GO:0007638 8 6 0,000 6,504E-03 0,04076219 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 6,504E-03 0,04065143 ! negative regulation of endocytosis GO:0045806 8 6 0,000 6,504E-03 0,04054126 ! response to interferon-gamma GO:0034341 12 6 0,000 6,504E-03 0,04043169 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 6,504E-03 0,04032271 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 6,504E-03 0,04021431 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 6,504E-03 0,0401065 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 6,504E-03 0,03999926 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 6,504E-03 0,0398926 ! cGMP-mediated signaling GO:0019934 10 6 0,000 6,504E-03 0,0397865 ! activation of MAPKKK activity GO:0000185 10 6 0,000 6,504E-03 0,03968097 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 6,504E-03 0,03957599 ! thymic T cell selection GO:0045061 12 6 0,000 6,504E-03 0,03947157 ! protein lipoylation GO:0009249 10 6 0,000 6,504E-03 0,0393677 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 6,504E-03 0,03926437 ! pigment granule organization GO:0048753 11 6 0,000 6,504E-03 0,03916158 ! drug transport GO:0015893 6 6 0,000 6,504E-03 0,03905933 ! cysteine metabolic process GO:0006534 7 6 0,000 6,504E-03 0,03895762 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 6,504E-03 0,03885643 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 6,504E-03 0,03875576 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 6,504E-03 0,03865562 ! histidine metabolic process GO:0006547 6 6 0,000 6,504E-03 0,03855599 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 6,504E-03 0,03845688 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 6,504E-03 0,03835827 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 6,504E-03 0,03826017 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 6,504E-03 0,03816256 ! adenohypophysis development GO:0021984 10 6 0,000 6,504E-03 0,03806546 ! hyperosmotic response GO:0006972 8 6 0,000 6,504E-03 0,03796885 ! microtubule nucleation GO:0007020 10 6 0,000 6,504E-03 0,03787272 ! ER overload response GO:0006983 7 6 0,000 6,504E-03 0,03777708 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 6,504E-03 0,03768193 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 6,504E-03 0,03758725 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 6,504E-03 0,03749305 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 6,504E-03 0,03739931 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 6,504E-03 0,03730605 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 6,504E-03 0,03721325 ! response to dietary excess GO:0002021 7 6 0,000 6,504E-03 0,03712091 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 6,504E-03 0,03702902 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 6,504E-03 0,03693759 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 6,504E-03 0,03684661 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 6,504E-03 0,03675608 ! glycerol ether catabolic process GO:0044269 8 6 0,000 6,504E-03 0,03666599 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 6,504E-03 0,03657634 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 6,504E-03 0,03648713 ! neuron apoptosis GO:0051402 8 6 0,000 6,504E-03 0,03639836 ! organic alcohol transport GO:0015850 9 6 0,000 6,504E-03 0,03631001 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 6,504E-03 0,03622209 ! T cell mediated immunity GO:0002456 12 6 0,000 6,504E-03 0,0361346 ! male sex determination GO:0030238 9 6 0,000 6,504E-03 0,03604753 ! carnitine transport GO:0015879 8 6 0,000 6,504E-03 0,03596088 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 6,504E-03 0,03587464 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 6,504E-03 0,03578882 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 6,504E-03 0,0357034 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 6,504E-03 0,03561839 ! positive regulation of exocytosis GO:0045921 6 6 0,000 6,504E-03 0,03553379 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 6,504E-03 0,03544959 ! parturition GO:0007567 12 6 0,000 6,504E-03 0,03536578 ! negative regulation of translational initiation GO:0045947 7 6 0,000 6,504E-03 0,03528237 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 6,504E-03 0,03519935 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 6,504E-03 0,03511673 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 6,504E-03 0,03503448 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 6,504E-03 0,03495263 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 6,504E-03 0,03487115 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 6,504E-03 0,03479006 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 6,504E-03 0,03470934 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 6,504E-03 0,03462899 ! macrophage differentiation GO:0030225 10 6 0,000 6,504E-03 0,03454902 ! astrocyte development GO:0014002 14 6 0,000 6,504E-03 0,03446941 ! hyaluronan metabolic process GO:0030212 6 6 0,000 6,504E-03 0,03439017 ! purine base biosynthetic process GO:0009113 14 6 0,000 6,504E-03 0,0343113 ! interaction with symbiont GO:0051702 8 6 0,000 6,504E-03 0,03423278 ! anterograde axon cargo transport GO:0008089 8 6 0,000 6,504E-03 0,03415462 ! skeletal muscle contraction GO:0003009 6 6 0,000 6,504E-03 0,03407682 ! eating behavior GO:0042755 6 6 0,000 6,504E-03 0,03399938 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 6,504E-03 0,03392228 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 6,504E-03 0,03384553 ! response to copper ion GO:0046688 9 6 0,000 6,504E-03 0,03376913 ! DNA topological change GO:0006265 8 6 0,000 6,504E-03 0,03369307 ! response to exogenous dsRNA GO:0043330 8 6 0,000 6,504E-03 0,03361736 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 6,504E-03 0,03354198 ! establishment of melanosome localization GO:0032401 9 6 0,000 6,504E-03 0,03346695 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 6,504E-03 0,03339224 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 6,504E-03 0,03331787 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 6,504E-03 0,03324383 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 6,504E-03 0,03317012 ! nucleoside catabolic process GO:0009164 6 6 0,000 6,504E-03 0,03309674 ! gas homeostasis GO:0033483 11 6 0,000 6,504E-03 0,03302368 ! hair follicle maturation GO:0048820 7 6 0,000 6,504E-03 0,03295094 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 6,504E-03 0,03287852 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 6,504E-03 0,03280641 ! Schwann cell development GO:0014044 14 6 0,000 6,504E-03 0,03273463 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 6,504E-03 0,03266316 ! dendrite morphogenesis GO:0048813 9 6 0,000 6,504E-03 0,03259199 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 6,504E-03 0,03252114 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 6,504E-03 0,0324506 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 6,504E-03 0,03238036 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 6,504E-03 0,03231042 ! histone ubiquitination GO:0016574 7 6 0,000 6,504E-03 0,03224079 ! regulation of meiosis GO:0040020 10 6 0,000 6,504E-03 0,03217145 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 6,504E-03 0,03210241 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 6,504E-03 0,03203367 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 6,504E-03 0,03196522 ! regulation of mast cell activation GO:0033003 6 6 0,000 6,504E-03 0,03189707 ! membrane to membrane docking GO:0022614 12 6 0,000 6,504E-03 0,0318292 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 6,504E-03 0,03176162 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 6,504E-03 0,03169433 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 6,504E-03 0,03162733 ! receptor internalization GO:0031623 9 6 0,000 6,504E-03 0,0315606 ! neutrophil homeostasis GO:0001780 6 6 0,000 6,504E-03 0,03149416 ! coenzyme A metabolic process GO:0015936 9 6 0,000 6,504E-03 0,03142799 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 6,504E-03 0,03136211 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 6,504E-03 0,0312965 ! protein deubiquitination GO:0016579 8 6 0,000 6,504E-03 0,03123116 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 6,504E-03 0,03116609 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 6,504E-03 0,0311013 ! peptidyl-histidine modification GO:0018202 9 6 0,000 6,504E-03 0,03103677 ! axonal fasciculation GO:0007413 9 6 0,000 6,504E-03 0,03097252 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 6,504E-03 0,03090852 ! thiamin metabolic process GO:0006772 6 6 0,000 6,504E-03 0,03084479 ! midbrain development GO:0030901 6 6 0,000 6,504E-03 0,03078133 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 6,504E-03 0,03071812 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 6,504E-03 0,03065517 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 6,504E-03 0,03059248 ! progesterone metabolic process GO:0042448 8 6 0,000 6,504E-03 0,03053005 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 6,504E-03 0,03046787 ! glycolipid catabolic process GO:0019377 13 6 0,000 6,504E-03 0,03040595 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 6,504E-03 0,03034427 ! positive regulation of glucose import GO:0046326 6 6 0,000 6,504E-03 0,03028284 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 6,504E-03 0,03022167 ! adult feeding behavior GO:0008343 6 6 0,000 6,504E-03 0,03016074 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 6,504E-03 0,03010005 ! blastocyst growth GO:0001832 15 6 0,000 6,504E-03 0,03003961 ! pigment granule transport GO:0051904 12 6 0,000 6,504E-03 0,02997941 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 6,504E-03 0,02991945 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 6,504E-03 0,02985973 ! catecholamine transport GO:0051937 7 6 0,000 6,504E-03 0,02980025 ! organ or tissue specific immune response GO:0002251 7 6 0,000 6,504E-03 0,029741 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 6,504E-03 0,02968199 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 6,504E-03 0,02962322 ! negative regulation of B cell activation GO:0050869 9 6 0,000 6,504E-03 0,02956467 ! protein prenylation GO:0018342 10 6 0,000 6,504E-03 0,02950636 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 6,504E-03 0,02944828 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 6,504E-03 0,02939042 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 6,504E-03 0,02933279 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 6,504E-03 0,02927539 ! positive regulation of coagulation GO:0050820 11 6 0,000 6,504E-03 0,02921821 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 7,584E-03 0,03400396 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 7,584E-03 0,03393781 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 7,584E-03 0,03387191 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 7,584E-03 0,03380627 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 7,584E-03 0,03374088 ! synaptonemal complex assembly GO:0007130 10 7 0,000 7,584E-03 0,03367574 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 7,584E-03 0,03361085 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 7,584E-03 0,03354622 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 7,584E-03 0,03348183 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 7,584E-03 0,03341769 ! reproductive behavior GO:0019098 12 7 0,000 7,584E-03 0,03335379 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 7,584E-03 0,03329014 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 7,584E-03 0,03322673 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 7,584E-03 0,03316356 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 7,584E-03 0,03310063 ! oligopeptide transport GO:0006857 11 7 0,000 7,584E-03 0,03303794 ! protein amino acid sulfation GO:0006477 9 7 0,000 7,584E-03 0,03297549 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 7,584E-03 0,03291327 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 7,584E-03 0,03285129 ! RNA methylation GO:0001510 11 7 0,000 7,584E-03 0,03278954 ! pericardium development GO:0060039 8 7 0,000 7,584E-03 0,03272802 ! macrophage chemotaxis GO:0048246 10 7 0,000 7,584E-03 0,03266673 ! fibril organization GO:0043206 13 7 0,000 7,584E-03 0,03260567 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 7,584E-03 0,03254484 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 7,584E-03 0,03248423 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 7,584E-03 0,03242385 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 7,584E-03 0,0323637 ! lipoprotein transport GO:0042953 9 7 0,000 7,584E-03 0,03230376 ! cerebral cortex cell migration GO:0021795 11 7 0,000 7,584E-03 0,03224405 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 7,584E-03 0,03218456 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 7,584E-03 0,03212529 ! estrogen metabolic process GO:0008210 14 7 0,000 7,584E-03 0,03206624 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 7,584E-03 0,0320074 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 7,584E-03 0,03194878 ! chemosensory behavior GO:0007635 9 7 0,000 7,584E-03 0,03189037 ! microtubule bundle formation GO:0001578 8 7 0,000 7,584E-03 0,03183218 ! T-helper 1 type immune response GO:0042088 11 7 0,000 7,584E-03 0,03177419 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 7,584E-03 0,03171642 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 7,584E-03 0,03165886 ! leukocyte degranulation GO:0043299 10 7 0,000 7,584E-03 0,03160151 ! bile acid and bile salt transport GO:0015721 9 7 0,000 7,584E-03 0,03154436 ! reflex GO:0060004 12 7 0,000 7,584E-03 0,03148742 ! positive regulation of isotype switching GO:0045830 15 7 0,000 7,584E-03 0,03143069 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 7,584E-03 0,03137416 ! protein-cofactor linkage GO:0018065 13 7 0,000 7,584E-03 0,03131783 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 7,584E-03 0,03126171 ! glycerolipid catabolic process GO:0046503 9 7 0,000 7,584E-03 0,03120578 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 7,584E-03 0,03115006 ! spinal cord patterning GO:0021511 7 7 0,000 7,584E-03 0,03109453 ! hemoglobin metabolic process GO:0020027 10 7 0,000 7,584E-03 0,0310392 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 7,584E-03 0,03098407 ! adrenal gland development GO:0030325 17 7 0,000 7,584E-03 0,03092914 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 7,584E-03 0,03087439 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 7,584E-03 0,03081985 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 7,584E-03 0,03076549 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 7,584E-03 0,03071133 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 7,584E-03 0,03065735 ! endosome organization GO:0007032 10 7 0,000 7,584E-03 0,03060357 ! thyroid hormone generation GO:0006590 11 7 0,000 7,584E-03 0,03054997 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 7,584E-03 0,03049656 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 7,584E-03 0,03044334 ! regulation of pigmentation during development GO:0048070 15 7 0,000 7,584E-03 0,0303903 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 7,584E-03 0,03033745 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 7,584E-03 0,03028478 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 7,584E-03 0,03023229 ! galactose metabolic process GO:0006012 10 7 0,000 7,584E-03 0,03017999 ! vesicle fusion GO:0006906 15 7 0,000 7,584E-03 0,03012786 ! intracellular pH reduction GO:0051452 10 7 0,000 7,584E-03 0,03007592 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 7,584E-03 0,03002415 ! organ growth GO:0035265 11 7 0,000 7,584E-03 0,02997257 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 7,584E-03 0,02992115 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 7,584E-03 0,02986992 ! Rac protein signal transduction GO:0016601 7 7 0,000 7,584E-03 0,02981886 ! retinol metabolic process GO:0042572 9 7 0,000 7,584E-03 0,02976797 ! behavioral fear response GO:0001662 13 7 0,000 7,584E-03 0,02971726 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 7,584E-03 0,02966672 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 7,584E-03 0,02961635 ! rRNA modification GO:0000154 12 7 0,000 7,584E-03 0,02956616 ! protein heterooligomerization GO:0051291 10 7 0,000 7,584E-03 0,02951613 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 7,584E-03 0,02946627 ! response to UV-B GO:0010224 11 7 0,000 7,584E-03 0,02941658 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 7,584E-03 0,02936706 ! protein retention in ER lumen GO:0006621 12 7 0,000 7,584E-03 0,0293177 ! intermediate filament organization GO:0045109 11 7 0,000 7,584E-03 0,02926851 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 7,584E-03 0,02921949 ! cardiac muscle cell development GO:0055013 9 7 0,000 7,584E-03 0,02917062 ! fibrinolysis GO:0042730 9 7 0,000 7,584E-03 0,02912192 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 7,584E-03 0,02907339 ! regulation of circadian rhythm GO:0042752 11 7 0,000 7,584E-03 0,02902501 ! B cell lineage commitment GO:0002326 17 7 0,000 7,584E-03 0,0289768 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 7,584E-03 0,02892874 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 7,584E-03 0,02888085 ! response to tropane GO:0014073 13 7 0,000 7,584E-03 0,02883311 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 7,584E-03 0,02878553 ! melanosome localization GO:0032400 10 7 0,000 7,584E-03 0,02873811 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 7,584E-03 0,02869084 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 7,584E-03 0,02864373 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 7,584E-03 0,02859678 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 7,584E-03 0,02854997 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 7,584E-03 0,02850332 ! mast cell activation GO:0045576 9 7 0,000 7,584E-03 0,02845682 ! multicellular organismal aging GO:0010259 11 7 0,000 7,584E-03 0,02841048 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 7,584E-03 0,02836428 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 7,584E-03 0,02831824 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 7,584E-03 0,02827234 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 7,584E-03 0,02822659 ! establishment of nucleus localization GO:0040023 13 7 0,000 7,584E-03 0,02818099 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 7,584E-03 0,02813554 ! T cell lineage commitment GO:0002360 12 7 0,000 7,584E-03 0,02809023 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 7,584E-03 0,02804507 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 7,584E-03 0,02800005 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 7,584E-03 0,02795518 ! regulation of lipid transport GO:0032368 13 7 0,000 7,584E-03 0,02791045 ! response to tumor cell GO:0002347 12 7 0,000 7,584E-03 0,02786587 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 7,584E-03 0,02782142 ! neuroblast proliferation GO:0007405 13 7 0,000 7,584E-03 0,02777712 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 7,584E-03 0,02773296 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 7,584E-03 0,02768894 ! peptidyl-threonine modification GO:0018210 18 7 0,000 7,584E-03 0,02764506 ! diuresis GO:0030146 12 7 0,000 7,584E-03 0,02760132 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 7,584E-03 0,02755771 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 7,584E-03 0,02751425 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 7,584E-03 0,02747092 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 7,584E-03 0,02742772 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 7,584E-03 0,02738467 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 7,584E-03 0,02734174 ! melanin biosynthetic process GO:0042438 8 7 0,000 7,584E-03 0,02729896 ! regulation of synaptogenesis GO:0051963 10 7 0,000 7,584E-03 0,0272563 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 7,584E-03 0,02721378 ! dopamine biosynthetic process GO:0042416 15 7 0,000 7,584E-03 0,02717139 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 7,584E-03 0,02712913 ! lymph node development GO:0048535 9 7 0,000 7,584E-03 0,02708701 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 7,584E-03 0,02704501 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 7,584E-03 0,02700315 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 7,584E-03 0,02696141 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 7,584E-03 0,0269198 ! endosome to lysosome transport GO:0008333 10 7 0,000 7,584E-03 0,02687833 ! ATP catabolic process GO:0006200 10 7 0,000 7,584E-03 0,02683697 ! establishment of pigment granule localization GO:0051905 13 7 0,000 7,584E-03 0,02679575 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 7,584E-03 0,02675465 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 7,584E-03 0,02671368 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 7,584E-03 0,02667283 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 7,584E-03 0,02663211 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 7,584E-03 0,02659151 ! muscle adaptation GO:0043500 12 7 0,000 7,584E-03 0,02655104 ! amino sugar catabolic process GO:0046348 9 7 0,000 7,584E-03 0,02651069 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 7,584E-03 0,02647046 ! retina homeostasis GO:0001895 9 7 0,000 7,584E-03 0,02643035 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 7,584E-03 0,02639037 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 7,584E-03 0,0263505 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 7,584E-03 0,02631076 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 7,584E-03 0,02627113 ! behavioral response to nicotine GO:0035095 11 7 0,000 7,584E-03 0,02623163 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 7,584E-03 0,02619224 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 7,584E-03 0,02615297 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 8,663E-03 0,02982901 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 8,663E-03 0,02978443 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 8,663E-03 0,02973997 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 8,663E-03 0,02969565 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 8,663E-03 0,02965146 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 8,663E-03 0,0296074 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 8,663E-03 0,02956347 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 8,663E-03 0,02951968 ! cell proliferation in forebrain GO:0021846 10 8 0,000 8,663E-03 0,02947601 ! phosphate transport GO:0006817 10 8 0,000 8,663E-03 0,02943247 ! N-glycan processing GO:0006491 12 8 0,000 8,663E-03 0,02938906 ! Golgi to endosome transport GO:0006895 16 8 0,000 8,663E-03 0,02934578 ! UTP metabolic process GO:0046051 8 8 0,000 8,663E-03 0,02930262 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 8,663E-03 0,02925959 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 8,663E-03 0,02921669 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 8,663E-03 0,02917391 ! neurotransmitter uptake GO:0001504 10 8 0,000 8,663E-03 0,02913126 ! succinate metabolic process GO:0006105 14 8 0,000 8,663E-03 0,02908873 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 8,663E-03 0,02904633 ! smoothened signaling pathway GO:0007224 8 8 0,000 8,663E-03 0,02900405 ! membrane hyperpolarization GO:0060081 10 8 0,000 8,663E-03 0,02896189 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 8,663E-03 0,02891986 ! middle ear morphogenesis GO:0042474 9 8 0,000 8,663E-03 0,02887794 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 8,663E-03 0,02883615 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 8,663E-03 0,02879448 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 8,663E-03 0,02875293 ! ganglioside metabolic process GO:0001573 15 8 0,000 8,663E-03 0,0287115 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 8,663E-03 0,02867019 ! pseudouridine synthesis GO:0001522 9 8 0,000 8,663E-03 0,028629 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 8,663E-03 0,02858792 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 8,663E-03 0,02854697 ! endothelial cell differentiation GO:0045446 14 8 0,000 8,663E-03 0,02850613 ! ceramide biosynthetic process GO:0046513 9 8 0,000 8,663E-03 0,0284654 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 8,663E-03 0,0284248 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 8,663E-03 0,0283843 ! astrocyte differentiation GO:0048708 16 8 0,000 8,663E-03 0,02834393 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 8,663E-03 0,02830367 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 8,663E-03 0,02826352 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 8,663E-03 0,02822349 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 8,663E-03 0,02818357 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 8,663E-03 0,02814376 ! melanin metabolic process GO:0006582 12 8 0,000 8,663E-03 0,02810406 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 8,663E-03 0,02806448 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 8,663E-03 0,02802501 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 8,663E-03 0,02798565 ! macrophage activation GO:0042116 12 8 0,000 8,663E-03 0,0279464 ! regulation of type I interferon production GO:0032479 8 8 0,000 8,663E-03 0,02790726 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 8,663E-03 0,02786823 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 8,663E-03 0,0278293 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 8,663E-03 0,02779049 ! regulation of vascular permeability GO:0043114 12 8 0,000 8,663E-03 0,02775179 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 8,663E-03 0,02771319 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 8,663E-03 0,0276747 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 8,663E-03 0,02763631 ! ruffle organization GO:0031529 11 8 0,000 8,663E-03 0,02759804 ! osteoblast development GO:0002076 13 8 0,000 8,663E-03 0,02755986 ! lens development in camera-type eye GO:0002088 10 8 0,000 8,663E-03 0,0275218 ! positive regulation of vasodilation GO:0045909 12 8 0,000 8,663E-03 0,02748384 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 8,663E-03 0,02744598 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 8,663E-03 0,02740823 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 8,663E-03 0,02737058 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 8,663E-03 0,02733303 ! Schwann cell differentiation GO:0014037 17 8 0,000 8,663E-03 0,02729559 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 8,663E-03 0,02725825 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 8,663E-03 0,02722101 ! regulation of gliogenesis GO:0014013 20 8 0,000 8,663E-03 0,02718388 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 8,663E-03 0,02714684 ! oligodendrocyte development GO:0014003 8 8 0,000 8,663E-03 0,02710991 ! segment specification GO:0007379 10 8 0,000 8,663E-03 0,02707307 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 8,663E-03 0,02703634 ! cellular extravasation GO:0045123 11 8 0,000 8,663E-03 0,0269997 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 8,663E-03 0,02696317 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 8,663E-03 0,02692673 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 8,663E-03 0,02689039 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 8,663E-03 0,02685415 ! snRNA metabolic process GO:0016073 10 8 0,000 8,663E-03 0,02681801 GO:0016180|snRNA processing, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 0,000 8,663E-03 0,02678196 ! regulation of interleukin-4 production GO:0032673 16 8 0,000 8,663E-03 0,02674602 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 8,663E-03 0,02671016 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 8,663E-03 0,02667441 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 8,663E-03 0,02663875 ! nucleosome disassembly GO:0006337 12 8 0,000 8,663E-03 0,02660318 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 8,663E-03 0,02656771 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 8,663E-03 0,02653233 ! icosanoid secretion GO:0032309 12 8 0,000 8,663E-03 0,02649705 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 8,663E-03 0,02646186 ! leukocyte activation during immune response GO:0002366 13 8 0,000 8,663E-03 0,02642677 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 8,663E-03 0,02639176 ! cerebellum morphogenesis GO:0021587 9 8 0,000 8,663E-03 0,02635685 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 8,663E-03 0,02632204 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 8,663E-03 0,02628731 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 8,663E-03 0,02625268 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 8,663E-03 0,02621813 ! sterol catabolic process GO:0016127 9 8 0,000 8,663E-03 0,02618368 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 8,663E-03 0,02614932 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 8,663E-03 0,02611505 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 8,663E-03 0,02608087 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 8,663E-03 0,02604677 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 8,663E-03 0,02601277 ! prophase GO:0051324 11 8 0,000 8,663E-03 0,02597886 ! S phase GO:0051320 8 8 0,000 8,663E-03 0,02594503 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 8,663E-03 0,02591129 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 8,663E-03 0,02587764 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 8,663E-03 0,02584408 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 8,663E-03 0,0258106 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 8,663E-03 0,02577721 ! hormone catabolic process GO:0042447 13 8 0,000 8,663E-03 0,0257439 ! quaternary ammonium group transport GO:0015697 10 8 0,000 8,663E-03 0,02571069 ! myeloid cell homeostasis GO:0002262 8 8 0,000 8,663E-03 0,02567755 ! regulation of fibrinolysis GO:0051917 13 8 0,000 8,663E-03 0,02564451 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 8,663E-03 0,02561154 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 8,663E-03 0,02557867 ! regulation of telomere maintenance GO:0032204 10 8 0,000 8,663E-03 0,02554587 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 8,663E-03 0,02551317 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 8,663E-03 0,02548054 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 8,663E-03 0,025448 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 8,663E-03 0,02541554 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 8,663E-03 0,02538316 ! lamellipodium assembly GO:0030032 9 8 0,000 8,663E-03 0,02535087 ! regulation of embryonic development GO:0045995 16 8 0,000 8,663E-03 0,02531866 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 8,663E-03 0,02528653 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 8,663E-03 0,02525448 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 8,663E-03 0,02522251 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 9,741E-03 0,02832487 ! regulation of developmental growth GO:0048638 13 9 0,000 9,741E-03 0,02828911 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 9,741E-03 0,02825344 ! telencephalon cell migration GO:0022029 16 9 0,000 9,741E-03 0,02821785 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 9,741E-03 0,02818236 ! pentose-phosphate shunt GO:0006098 12 9 0,000 9,741E-03 0,02814695 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 9,741E-03 0,02811164 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 9,741E-03 0,02807641 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 9,741E-03 0,02804127 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 9,741E-03 0,02800622 ! GTP metabolic process GO:0046039 9 9 0,000 9,741E-03 0,02797125 ! elastic fiber assembly GO:0048251 13 9 0,000 9,741E-03 0,02793638 ! social behavior GO:0035176 14 9 0,000 9,741E-03 0,02790159 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 9,741E-03 0,02786688 ! artery development GO:0060840 19 9 0,000 9,741E-03 0,02783227 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 9,741E-03 0,02779774 ! regulation of glycolysis GO:0006110 15 9 0,000 9,741E-03 0,02776329 ! response to pain GO:0048265 16 9 0,000 9,741E-03 0,02772893 ! protein complex disassembly GO:0043241 17 9 0,000 9,741E-03 0,02769465 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 9,741E-03 0,02766046 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 9,741E-03 0,02762636 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 9,741E-03 0,02759233 ! lung alveolus development GO:0048286 17 9 0,000 9,741E-03 0,02755839 ! ciliary or flagellar motility GO:0001539 10 9 0,000 9,741E-03 0,02752454 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 9,741E-03 0,02749077 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 9,741E-03 0,02745708 ! regulation of exit from mitosis GO:0007096 12 9 0,000 9,741E-03 0,02742347 ! ventral spinal cord development GO:0021517 11 9 0,000 9,741E-03 0,02738994 ! protein targeting to ER GO:0045047 19 9 0,000 9,741E-03 0,0273565 ! T cell selection GO:0045058 18 9 0,000 9,741E-03 0,02732314 ! endoderm development GO:0007492 12 9 0,000 9,741E-03 0,02728986 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 9,741E-03 0,02725666 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 9,741E-03 0,02722354 ! arginine catabolic process GO:0006527 10 9 0,000 9,741E-03 0,0271905 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 9,741E-03 0,02715754 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 9,741E-03 0,02712467 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 9,741E-03 0,02709187 ! phosphagen metabolic process GO:0006599 12 9 0,000 9,741E-03 0,02705915 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 9,741E-03 0,02702651 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 9,741E-03 0,02699395 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 9,741E-03 0,02696146 ! mannose metabolic process GO:0006013 9 9 0,000 9,741E-03 0,02692906 ! substrate-bound cell migration GO:0006929 10 9 0,000 9,741E-03 0,02689673 ! receptor clustering GO:0043113 15 9 0,000 9,741E-03 0,02686448 ! epithelial cell development GO:0002064 10 9 0,000 9,741E-03 0,0268323 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 9,741E-03 0,02680021 ! retinoic acid metabolic process GO:0042573 11 9 0,000 9,741E-03 0,02676819 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 9,741E-03 0,02673625 ! positive regulation of translational initiation GO:0045948 10 9 0,000 9,741E-03 0,02670438 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 9,741E-03 0,02667259 ! motor axon guidance GO:0008045 14 9 0,000 9,741E-03 0,02664087 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 9,741E-03 0,02660923 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 9,741E-03 0,02657767 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 9,741E-03 0,02654618 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 9,741E-03 0,02651476 ! blastoderm segmentation GO:0007350 11 9 0,000 9,741E-03 0,02648342 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 9,741E-03 0,02645215 ! DNA ligation GO:0006266 14 9 0,000 9,741E-03 0,02642096 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 9,741E-03 0,02638984 ! response to amine stimulus GO:0014075 13 9 0,000 9,741E-03 0,02635879 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 9,741E-03 0,02632782 ! erythrocyte development GO:0048821 11 9 0,000 9,741E-03 0,02629692 ! renal water homeostasis GO:0003091 14 9 0,000 9,741E-03 0,02626609 ! postreplication repair GO:0006301 11 9 0,000 9,741E-03 0,02623533 ! mRNA cleavage GO:0006379 13 9 0,000 9,741E-03 0,02620465 ! hindbrain morphogenesis GO:0021575 12 9 0,000 9,741E-03 0,02617404 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 9,741E-03 0,02614349 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 9,741E-03 0,02611302 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 9,741E-03 0,02608262 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 9,741E-03 0,0260523 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 9,741E-03 0,02602204 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 9,741E-03 0,02599185 ! acid secretion GO:0046717 14 9 0,000 9,741E-03 0,02596173 ! musculoskeletal movement GO:0050881 11 9 0,000 9,741E-03 0,02593168 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 9,741E-03 0,0259017 ! methionine biosynthetic process GO:0009086 10 9 0,000 9,741E-03 0,02587179 ! purine base metabolic process GO:0006144 18 9 0,000 9,741E-03 0,02584195 ! oocyte differentiation GO:0009994 12 9 0,000 9,741E-03 0,02581218 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 9,741E-03 0,02578248 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 9,741E-03 0,02575284 ! spleen development GO:0048536 15 9 0,000 9,741E-03 0,02572328 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 9,741E-03 0,02569378 ! anterior/posterior axis specification GO:0009948 11 9 0,000 9,741E-03 0,02566435 ! regulation of RNA splicing GO:0043484 14 9 0,000 9,741E-03 0,02563498 ! detection of calcium ion GO:0005513 13 9 0,000 9,741E-03 0,02560569 ! blastocyst formation GO:0001825 12 9 0,000 9,741E-03 0,02557645 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 9,741E-03 0,02554729 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 9,741E-03 0,02551819 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 9,741E-03 0,02548916 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 9,741E-03 0,0254602 ! regulation of amino acid transport GO:0051955 11 9 0,000 9,741E-03 0,0254313 ! positive regulation of amine transport GO:0051954 15 9 0,000 9,741E-03 0,02540247 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 9,741E-03 0,0253737 ! prepulse inhibition GO:0060134 14 9 0,000 9,741E-03 0,02534499 ! embryonic placenta development GO:0001892 12 9 0,000 9,741E-03 0,02531636 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 9,741E-03 0,02528778 ! insulin secretion GO:0030073 17 9 0,000 9,741E-03 0,02525927 ! sequestering of metal ion GO:0051238 11 9 0,000 9,741E-03 0,02523083 ! response to nicotine GO:0035094 16 9 0,000 9,741E-03 0,02520245 ! establishment of cell polarity GO:0030010 12 9 0,000 9,741E-03 0,02517413 ! nucleus localization GO:0051647 15 9 0,000 9,741E-03 0,02514587 ! regulation of synapse organization GO:0050807 12 9 0,000 9,741E-03 0,02511768 ! localization within membrane GO:0051668 15 9 0,000 9,741E-03 0,02508956 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,01081809 0,02783178 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,01081809 0,02780068 ! neuron fate specification GO:0048665 11 10 0,000 0,01081809 0,02776966 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,01081809 0,0277387 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,01081809 0,02770781 ! thyroid gland development GO:0030878 19 10 0,000 0,01081809 0,02767699 ! synapsis GO:0007129 13 10 0,000 0,01081809 0,02764624 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,01081809 0,02761555 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,01081809 0,02758494 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,01081809 0,02755439 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,01081809 0,02752391 ! sulfate transport GO:0008272 12 10 0,000 0,01081809 0,0274935 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,01081809 0,02746315 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,01081809 0,02743287 ! androgen metabolic process GO:0008209 13 10 0,000 0,01081809 0,02740266 ! phospholipid efflux GO:0033700 16 10 0,000 0,01081809 0,02737251 ! hippocampus development GO:0021766 19 10 0,000 0,01081809 0,02734243 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,01081809 0,02731242 ! blood vessel remodeling GO:0001974 21 10 0,000 0,01081809 0,02728247 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,01081809 0,02725259 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,01081809 0,02722277 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,01081809 0,02719302 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,01081809 0,02716333 ! pathogenesis GO:0009405 13 10 0,000 0,01081809 0,02713371 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,01081809 0,02710415 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,01081809 0,02707466 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,01081809 0,02704523 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,01081809 0,02701587 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,01081809 0,02698657 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,01081809 0,02695733 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,01081809 0,02692815 ! melanocyte differentiation GO:0030318 15 10 0,000 0,01081809 0,02689904 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,01081809 0,02686999 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,01081809 0,02684101 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,01081809 0,02681208 ! response to X-ray GO:0010165 16 10 0,000 0,01081809 0,02678322 ! B cell proliferation GO:0042100 14 10 0,000 0,01081809 0,02675442 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,01081809 0,02672569 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,01081809 0,02669701 ! forebrain cell migration GO:0021885 17 10 0,000 0,01081809 0,0266684 ! lipid digestion GO:0044241 15 10 0,000 0,01081809 0,02663984 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,01081809 0,02661135 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,01081809 0,02658292 ! UV protection GO:0009650 14 10 0,000 0,01081809 0,02655455 ! entry into host cell GO:0030260 20 10 0,000 0,01081809 0,02652624 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,01081809 0,02649799 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,01081809 0,0264698 ! negative regulation of ossification GO:0030279 19 10 0,000 0,01081809 0,02644167 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,01081809 0,0264136 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,01081809 0,02638559 ! regulation of bone resorption GO:0045124 24 10 0,000 0,01081809 0,02635764 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,01081809 0,02632975 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,01081809 0,02630192 ! regulation of organ growth GO:0046620 11 10 0,000 0,01081809 0,02627414 ! response to dsRNA GO:0043331 18 10 0,000 0,01081809 0,02624643 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,01081809 0,02621877 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,01081809 0,02619117 ! embryonic axis specification GO:0000578 12 10 0,000 0,01081809 0,02616363 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,01081809 0,02613615 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,01081809 0,02610872 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,01081809 0,02608136 ! cranial nerve development GO:0021545 12 10 0,000 0,01081809 0,02605405 ! fucose catabolic process GO:0019317 16 10 0,000 0,01081809 0,02602679 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,01081809 0,0259996 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,01081809 0,02597246 ! protein sumoylation GO:0016925 12 10 0,000 0,01081809 0,02594537 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,01081809 0,02591835 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,01081809 0,02589138 ! zymogen activation GO:0031638 14 10 0,000 0,01081809 0,02586446 ! salivary gland development GO:0007431 22 10 0,000 0,01081809 0,0258376 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,01081809 0,0258108 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,01081809 0,02578405 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,01081809 0,02575736 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,01081809 0,02573073 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,01081809 0,02570415 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,01081809 0,02567762 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,01081809 0,02565115 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,01081809 0,02562473 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,01081809 0,02559837 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,01081809 0,02557206 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,01081809 0,0255458 ! detection of bacterium GO:0016045 10 10 0,000 0,01081809 0,0255196 ! embryonic gut development GO:0048566 11 10 0,000 0,01081809 0,02549346 ! activation of innate immune response GO:0002218 10 10 0,000 0,01081809 0,02546736 GO:0002758|innate immune response-activating signal transduction, ! cardiac cell differentiation GO:0035051 16 10 0,000 0,01081809 0,02544132 ! developmental induction GO:0031128 13 10 0,000 0,01081809 0,02541534 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,01081809 0,0253894 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,01081809 0,02536352 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,01081809 0,02533769 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,01081809 0,02531192 ! rRNA transcription GO:0009303 17 11 0,000 0,01189378 0,02780051 ! respiratory burst GO:0045730 14 11 0,000 0,01189378 0,02777228 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,01189378 0,02774412 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,01189378 0,02771601 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,01189378 0,02768796 ! virus-host interaction GO:0019048 17 11 0,000 0,01189378 0,02765996 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,01189378 0,02763202 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,01189378 0,02760414 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,01189378 0,02757631 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,01189378 0,02754854 ! RNA polyadenylation GO:0043631 19 11 0,000 0,01189378 0,02752083 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,01189378 0,02749317 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,01189378 0,02746556 ! mating GO:0007618 14 11 0,000 0,01189378 0,02743801 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,01189378 0,02741052 ! T cell proliferation GO:0042098 20 11 0,000 0,01189378 0,02738308 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,01189378 0,0273557 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,01189378 0,02732837 ! bone resorption GO:0045453 16 11 0,000 0,01189378 0,0273011 ! regulated secretory pathway GO:0045055 14 11 0,000 0,01189378 0,02727388 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,01189378 0,02724671 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,01189378 0,0272196 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,01189378 0,02719254 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,01189378 0,02716554 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,01189378 0,02713859 ! syncytium formation GO:0006949 15 11 0,000 0,01189378 0,02711169 ! plasma membrane organization GO:0007009 18 11 0,000 0,01189378 0,02708485 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,01189378 0,02705806 ! focal adhesion formation GO:0048041 24 11 0,000 0,01189378 0,02703132 ! mitotic spindle organization GO:0007052 15 11 0,000 0,01189378 0,02700464 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,01189378 0,02697801 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,01189378 0,02695143 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,01189378 0,0269249 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,01189378 0,02689843 ! adult heart development GO:0007512 11 11 0,000 0,01189378 0,026872 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,01189378 0,02684563 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,01189378 0,02681931 ! temperature homeostasis GO:0001659 16 11 0,000 0,01189378 0,02679305 ! L-glutamate transport GO:0015813 16 11 0,000 0,01189378 0,02676683 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,01189378 0,02674066 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,01189378 0,02671455 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,01189378 0,02668849 ! stem cell development GO:0048864 29 11 0,000 0,01189378 0,02666248 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,01189378 0,02663651 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,01189378 0,0266106 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,01189378 0,02658474 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,01189378 0,02655893 ! vasoconstriction GO:0042310 15 11 0,000 0,01189378 0,02653317 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,01189378 0,02650746 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,01189378 0,0264818 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,01189378 0,02645619 ! ribosome assembly GO:0042255 13 11 0,000 0,01189378 0,02643063 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,01189378 0,02640512 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,01189378 0,02637965 ! chromatin silencing GO:0006342 19 11 0,000 0,01189378 0,02635424 ! nucleosome positioning GO:0016584 13 11 0,000 0,01189378 0,02632887 ! T cell homeostasis GO:0043029 20 11 0,000 0,01189378 0,02630356 ! regulation of isotype switching GO:0045191 19 11 0,000 0,01189378 0,02627829 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,01189378 0,02625307 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,01189378 0,0262279 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,01189378 0,02620278 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,01189378 0,0261777 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,01189378 0,02615268 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,01189378 0,0261277 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,01189378 0,02610277 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,01189378 0,02607788 ! male genitalia development GO:0030539 13 11 0,000 0,01189378 0,02605305 ! cholesterol efflux GO:0033344 19 11 0,000 0,01189378 0,02602826 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,01189378 0,02600352 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,01189378 0,02597882 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,01189378 0,02595417 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,01189378 0,02592957 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,01189378 0,02590502 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,01189378 0,02588051 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,01189378 0,02585605 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,01189378 0,02583163 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,01189378 0,02580726 ! lysogeny GO:0030069 18 11 0,000 0,01189378 0,02578294 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,01189378 0,02575866 ! acrosome reaction GO:0007340 13 11 0,000 0,01189378 0,02573443 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,01189378 0,02571024 ! lactation GO:0007595 20 12 0,000 0,01296836 0,0280068 ! reproductive cellular process GO:0048610 14 12 0,000 0,01296836 0,02798052 ! tRNA modification GO:0006400 14 12 0,000 0,01296836 0,0279543 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,01296836 0,02792813 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,01296836 0,027902 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,01296836 0,02787592 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,01296836 0,0278499 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,01296836 0,02782392 ! non-recombinational repair GO:0000726 19 12 0,000 0,01296836 0,02779799 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,01296836 0,0277721 ! peroxisomal transport GO:0043574 21 12 0,000 0,01296836 0,02774627 ! cartilage condensation GO:0001502 18 12 0,000 0,01296836 0,02772048 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,01296836 0,02769474 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,01296836 0,02766905 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,01296836 0,02764341 ! heart looping GO:0001947 15 12 0,000 0,01296836 0,02761781 ! palate development GO:0060021 15 12 0,000 0,01296836 0,02759226 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,01296836 0,02756676 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,01296836 0,02754131 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,01296836 0,0275159 ! arginine metabolic process GO:0006525 13 12 0,000 0,01296836 0,02749054 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,01296836 0,02746523 ! methionine metabolic process GO:0006555 13 12 0,000 0,01296836 0,02743996 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,01296836 0,02741474 ! Golgi organization GO:0007030 18 12 0,000 0,01296836 0,02738957 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,01296836 0,02736444 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,01296836 0,02733936 ! monoamine transport GO:0015844 13 12 0,000 0,01296836 0,02731432 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,01296836 0,02728933 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,01296836 0,02726439 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,01296836 0,02723949 ! L-amino acid transport GO:0015807 20 12 0,000 0,01296836 0,02721463 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,01296836 0,02718983 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,01296836 0,02716506 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,01296836 0,02714034 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,01296836 0,02711567 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,01296836 0,02709104 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,01296836 0,02706646 ! cerebellum development GO:0021549 13 12 0,000 0,01296836 0,02704192 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,01296836 0,02701743 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,01296836 0,02699298 ! histone acetylation GO:0016573 23 12 0,000 0,01296836 0,02696857 ! histone methylation GO:0016571 15 12 0,000 0,01296836 0,02694421 ! autonomic nervous system development GO:0048483 23 12 0,000 0,01296836 0,02691989 ! gland morphogenesis GO:0022612 23 12 0,000 0,01296836 0,02689562 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,01296836 0,02687139 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,01296836 0,0268472 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,01296836 0,02682306 ! response to gamma radiation GO:0010332 20 12 0,000 0,01296836 0,02679896 ! regulation of epidermis development GO:0045682 17 12 0,000 0,01296836 0,0267749 ! intestinal absorption GO:0050892 19 12 0,000 0,01296836 0,02675089 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,01296836 0,02672692 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,01296836 0,02670299 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,01296836 0,0266791 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,01296836 0,02665526 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,01296836 0,02663146 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,01296836 0,02660771 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,01296836 0,02658399 ! microspike assembly GO:0030035 23 12 0,000 0,01296836 0,02656032 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,01296836 0,02653669 ! response to cold GO:0009409 14 12 0,000 0,01296836 0,0265131 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,01404184 0,02868226 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,01404184 0,02865681 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,01404184 0,02863141 ! cGMP metabolic process GO:0046068 16 13 0,000 0,01404184 0,02860605 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,01404184 0,02858073 ! water transport GO:0006833 17 13 0,000 0,01404184 0,02855546 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,01404184 0,02853024 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,01404184 0,02850506 ! lipid localization GO:0010876 24 13 0,000 0,01404184 0,02847992 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,01404184 0,02845483 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,01404184 0,02842978 ! organelle fusion GO:0048284 28 13 0,000 0,01404184 0,02840478 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,01404184 0,02837982 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,01404184 0,0283549 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,01404184 0,02833003 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,01404184 0,0283052 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,01404184 0,02828041 ! response to hexose stimulus GO:0009746 19 13 0,000 0,01404184 0,02825567 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,01404184 0,02823097 ! glutamate metabolic process GO:0006536 18 13 0,000 0,01404184 0,02820631 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,01404184 0,0281817 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,01404184 0,02815713 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,01404184 0,0281326 ! NAD metabolic process GO:0019674 21 13 0,000 0,01404184 0,02810812 ! exocrine system development GO:0035272 27 13 0,000 0,01404184 0,02808368 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,01404184 0,02805928 ! bone mineralization GO:0030282 15 13 0,000 0,01404184 0,02803492 ! regulation of exocytosis GO:0017157 17 13 0,000 0,01404184 0,02801061 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,01404184 0,02798633 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,01404184 0,0279621 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,01404184 0,02793791 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,01404184 0,02791377 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,01404184 0,02788966 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,01404184 0,0278656 ! genitalia development GO:0048806 15 13 0,000 0,01404184 0,02784158 ! regulation of cellular pH GO:0030641 20 13 0,000 0,01404184 0,0278176 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,01404184 0,02779366 ! cellular pigmentation GO:0033059 24 13 0,000 0,01404184 0,02776976 ! tissue regeneration GO:0042246 21 13 0,000 0,01404184 0,0277459 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,01404184 0,02772209 ! cofactor transport GO:0051181 19 13 0,000 0,01404184 0,02769831 ! NADP metabolic process GO:0006739 18 13 0,000 0,01404184 0,02767458 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,01404184 0,02765088 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,01404184 0,02762723 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,01404184 0,02760362 ! gas transport GO:0015669 18 13 0,000 0,01404184 0,02758004 ! regulation of RNA stability GO:0043487 28 13 0,000 0,01404184 0,02755651 ! heme biosynthetic process GO:0006783 20 13 0,000 0,01404184 0,02753302 ! regulation of axon extension GO:0030516 23 13 0,000 0,01404184 0,02750957 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,01404184 0,02748615 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,01404184 0,02746278 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,01404184 0,02743945 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,01404184 0,02741615 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,01404184 0,0273929 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,01404184 0,02736969 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,01511421 0,02943495 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,01511421 0,02941005 ! superoxide anion generation GO:0042554 18 14 0,000 0,01511421 0,02938519 ! neuron maturation GO:0042551 21 14 0,000 0,01511421 0,02936037 ! regulation of S phase GO:0033261 18 14 0,000 0,01511421 0,02933559 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,01511421 0,02931086 ! myotube differentiation GO:0014902 21 14 0,000 0,01511421 0,02928616 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,01511421 0,02926151 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,01511421 0,0292369 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,01511421 0,02921233 ! inositol metabolic process GO:0006020 20 14 0,000 0,01511421 0,02918781 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,01511421 0,02916332 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,01511421 0,02913887 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,01511421 0,02911447 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,01511421 0,02909011 ! gene silencing by RNA GO:0031047 20 14 0,000 0,01511421 0,02906578 ! response to cAMP GO:0051591 19 14 0,000 0,01511421 0,0290415 ! limbic system development GO:0021761 25 14 0,000 0,01511421 0,02901726 ! startle response GO:0001964 21 14 0,000 0,01511421 0,02899306 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,01511421 0,0289689 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,01511421 0,02894478 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,01511421 0,0289207 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,01511421 0,02889666 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,01511421 0,02887266 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,01511421 0,02884869 ! glycine metabolic process GO:0006544 22 14 0,000 0,01511421 0,02882477 ! pituitary gland development GO:0021983 23 14 0,000 0,01511421 0,02880089 ! cellular response to starvation GO:0009267 21 14 0,000 0,01511421 0,02877705 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,01511421 0,02875325 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,01511421 0,02872949 ! regulation of heart rate GO:0002027 23 14 0,000 0,01511421 0,02870576 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,01511421 0,02868208 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,01511421 0,02865843 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,01511421 0,02863482 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,01511421 0,02861126 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,01511421 0,02858773 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,01511421 0,02856424 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,01511421 0,02854079 ! axon cargo transport GO:0008088 27 14 0,000 0,01511421 0,02851737 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,01511421 0,028494 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,01511421 0,02847066 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,01511421 0,02844736 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,01511421 0,0284241 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,01511421 0,02840088 ! mRNA splice site selection GO:0006376 26 14 0,000 0,01511421 0,0283777 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,01511421 0,02835455 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,01511421 0,02833144 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,01511421 0,02830837 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,01511421 0,02828534 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,01511421 0,02826234 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,01511421 0,02823938 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,01511421 0,02821646 ! muscle maintenance GO:0046716 19 14 0,000 0,01511421 0,02819357 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,01511421 0,02817073 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,01511421 0,02814792 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,01511421 0,02812514 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,01511421 0,02810241 ! cell killing GO:0001906 20 14 0,000 0,01511421 0,02807971 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,01511421 0,02805704 ! cilium assembly GO:0042384 20 14 0,000 0,01511421 0,02803442 ! peptide hormone secretion GO:0030072 23 14 0,000 0,01511421 0,02801183 ! metencephalon development GO:0022037 19 15 0,000 0,01618547 0,02997309 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,01618547 0,02994898 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,01618547 0,02992491 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,01618547 0,02990087 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,01618547 0,02987687 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,01618547 0,02985291 ! lipid phosphorylation GO:0046834 23 15 0,000 0,01618547 0,02982899 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,01618547 0,02980511 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,01618547 0,02978127 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,01618547 0,02975746 ! bile acid metabolic process GO:0008206 22 15 0,000 0,01618547 0,02973369 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,01618547 0,02970996 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,01618547 0,02968627 ! adult walking behavior GO:0007628 25 15 0,000 0,01618547 0,02966262 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,01618547 0,029639 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,01618547 0,02961542 ! myoblast differentiation GO:0045445 27 15 0,000 0,01618547 0,02959188 ! centrosome cycle GO:0007098 16 15 0,000 0,01618547 0,02956837 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,01618547 0,02954491 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,01618547 0,02952148 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,01618547 0,02949808 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,01618547 0,02947473 ! cerebral cortex development GO:0021987 29 15 0,000 0,01618547 0,02945141 ! response to osmotic stress GO:0006970 22 15 0,000 0,01618547 0,02942813 ! vesicle coating GO:0006901 25 15 0,000 0,01618547 0,02940488 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,01618547 0,02938168 ! DNA integration GO:0015074 22 15 0,000 0,01618547 0,0293585 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,01618547 0,02933537 ! peptide secretion GO:0002790 27 15 0,000 0,01618547 0,02931227 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,01618547 0,02928921 ! regulation of vasodilation GO:0042312 24 15 0,000 0,01618547 0,02926618 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,01618547 0,02924319 ! neuron recognition GO:0008038 22 15 0,000 0,01618547 0,02922024 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,01618547 0,02919732 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,01618547 0,02917444 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,01618547 0,02915159 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,01618547 0,02912878 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,01618547 0,02910601 ! biomineral formation GO:0031214 18 15 0,000 0,01618547 0,02908327 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,01618547 0,02906056 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,01618547 0,0290379 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,01618547 0,02901526 ! dopamine metabolic process GO:0042417 30 15 0,000 0,01618547 0,02899267 ! organic cation transport GO:0015695 19 15 0,000 0,01618547 0,0289701 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,01618547 0,02894758 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,01618547 0,02892508 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,01618547 0,02890263 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,01618547 0,0288802 ! defense response to virus GO:0051607 27 15 0,000 0,01618547 0,02885782 ! peptide hormone processing GO:0016486 19 15 0,000 0,01618547 0,02883546 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,01618547 0,02881314 ! protein secretion GO:0009306 27 16 0,000 0,01725563 0,03069447 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,01725563 0,03067075 ! hormone secretion GO:0046879 25 16 0,000 0,01725563 0,03064707 ! bone remodeling GO:0046849 24 16 0,000 0,01725563 0,03062342 ! endothelial cell migration GO:0043542 22 16 0,000 0,01725563 0,03059981 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,01725563 0,03057623 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,01725563 0,03055269 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,01725563 0,03052919 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,01725563 0,03050573 ! glial cell development GO:0021782 24 16 0,000 0,01725563 0,0304823 ! patterning of blood vessels GO:0001569 24 16 0,000 0,01725563 0,0304589 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,01725563 0,03043554 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,01725563 0,03041222 ! protein polyubiquitination GO:0000209 26 16 0,000 0,01725563 0,03038894 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,01725563 0,03036568 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,01725563 0,03034247 ! fructose metabolic process GO:0006000 20 16 0,000 0,01725563 0,03031929 ! regulation of protein binding GO:0043393 27 16 0,000 0,01725563 0,03029615 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,01725563 0,03027304 ! protein export from nucleus GO:0006611 24 16 0,000 0,01725563 0,03024996 ! negative regulation of immune response GO:0050777 28 16 0,000 0,01725563 0,03022692 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,01725563 0,03020392 ! DNA replication initiation GO:0006270 25 16 0,000 0,01725563 0,03018095 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,01725563 0,03015802 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,01725563 0,03013512 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,01725563 0,03011225 ! diencephalon development GO:0021536 25 16 0,000 0,01725563 0,03008942 ! oogenesis GO:0048477 23 16 0,000 0,01725563 0,03006663 ! neural crest cell migration GO:0001755 24 16 0,000 0,01725563 0,03004387 ! G1 phase GO:0051318 27 16 0,000 0,01725563 0,03002114 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,01725563 0,02999845 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,01725563 0,02997579 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,01725563 0,02995317 ! steroid catabolic process GO:0006706 22 16 0,000 0,01725563 0,02993058 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,01725563 0,02990803 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,01725563 0,0298855 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,01725563 0,02986302 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,01725563 0,02984056 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,01725563 0,02981814 ! sperm-egg recognition GO:0035036 16 16 0,000 0,01725563 0,02979576 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,01725563 0,02977341 ! nerve development GO:0021675 18 16 0,000 0,01725563 0,02975109 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,01725563 0,0297288 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,01725563 0,02970655 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,01832469 0,0315234 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,01832469 0,03149984 ! negative regulation of defense response GO:0031348 19 17 0,000 0,01832469 0,03147631 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,01832469 0,03145282 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,01832469 0,03142937 ! glycerol metabolic process GO:0006071 20 17 0,000 0,01832469 0,03140595 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,01832469 0,03138256 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,01832469 0,03135921 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,01832469 0,0313359 ! signal complex assembly GO:0007172 29 17 0,000 0,01832469 0,03131262 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,01832469 0,03128937 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,01832469 0,03126616 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,01832469 0,03124298 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,01832469 0,03121984 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,01832469 0,03119673 ! memory GO:0007613 25 17 0,000 0,01832469 0,03117365 ! keratinization GO:0031424 17 17 0,000 0,01832469 0,03115061 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,01832469 0,03112761 ! retinoid metabolic process GO:0001523 22 17 0,000 0,01832469 0,03110463 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,01832469 0,0310817 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,01832469 0,03105879 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,01832469 0,03103592 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,01832469 0,03101308 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,01832469 0,03099028 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,01832469 0,03096751 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,01832469 0,03094477 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,01832469 0,03092207 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,01832469 0,0308994 ! membrane budding GO:0006900 29 17 0,000 0,01832469 0,03087676 ! heme metabolic process GO:0042168 27 17 0,000 0,01832469 0,03085416 ! actin filament bundle formation GO:0051017 26 17 0,000 0,01832469 0,03083159 ! neuromuscular junction development GO:0007528 23 17 0,000 0,01832469 0,03080905 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,01832469 0,03078655 ! body fluid secretion GO:0007589 27 17 0,000 0,01832469 0,03076407 ! stem cell differentiation GO:0048863 36 17 0,000 0,01832469 0,03074163 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,01832469 0,03071923 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,01832469 0,03069685 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,01832469 0,03067451 ! sensory perception of pain GO:0019233 23 17 0,000 0,01832469 0,0306522 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,01832469 0,03062993 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,01832469 0,03060768 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,01832469 0,03058547 ! synaptogenesis GO:0007416 24 17 0,000 0,01832469 0,03056329 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,01832469 0,03054115 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,01832469 0,03051903 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,01832469 0,03049695 ! cell-cell junction organization GO:0045216 25 17 0,000 0,01832469 0,0304749 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,01832469 0,03045288 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,01832469 0,03043089 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,01832469 0,03040893 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,01832469 0,03038701 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,01832469 0,03036512 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,01832469 0,03034325 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,01939264 0,03208854 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,01939264 0,03206548 ! positive regulation of translation GO:0045727 28 18 0,000 0,01939264 0,03204244 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,01939264 0,03201944 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,01939264 0,03199647 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,01939264 0,03197353 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,01939264 0,03195063 ! cAMP metabolic process GO:0046058 33 18 0,000 0,01939264 0,03192776 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,01939264 0,03190492 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,01939264 0,03188211 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,01939264 0,03185934 ! axis specification GO:0009798 26 18 0,000 0,01939264 0,0318366 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,01939264 0,03181389 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,01939264 0,03179122 ! pancreas development GO:0031016 26 18 0,000 0,01939264 0,03176857 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,01939264 0,03174596 ! glutamine metabolic process GO:0006541 23 18 0,000 0,01939264 0,03172338 ! response to retinoic acid GO:0032526 25 18 0,000 0,01939264 0,03170084 ! pigmentation during development GO:0048066 31 18 0,000 0,01939264 0,03167832 ! central nervous system neuron development GO:0021954 30 18 0,000 0,01939264 0,03165584 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,01939264 0,03163339 ! fucose metabolic process GO:0006004 26 18 0,000 0,01939264 0,03161097 ! response to fungus GO:0009620 19 18 0,000 0,01939264 0,03158858 ! peptide cross-linking GO:0018149 31 18 0,000 0,01939264 0,03156623 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,01939264 0,0315439 ! heart process GO:0003015 27 18 0,000 0,01939264 0,03152161 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,01939264 0,03149935 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,01939264 0,03147712 ! visual learning GO:0008542 35 18 0,000 0,01939264 0,03145492 ! somitogenesis GO:0001756 24 18 0,000 0,01939264 0,03143275 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,01939264 0,03141062 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,01939264 0,03138851 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,01939264 0,03136644 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,01939264 0,0313444 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,01939264 0,03132239 ! vitamin transport GO:0051180 24 18 0,000 0,01939264 0,0313004 ! hormone transport GO:0009914 27 18 0,000 0,01939264 0,03127845 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,01939264 0,03125654 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,01939264 0,03123465 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,01939264 0,03121279 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,01939264 0,03119096 ! cell-cell recognition GO:0009988 20 18 0,000 0,01939264 0,03116917 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,01939264 0,0311474 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,01939264 0,03112566 ! regulation of glucose import GO:0046324 21 18 0,000 0,01939264 0,03110396 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,01939264 0,03108228 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,01939264 0,03106064 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,01939264 0,03103902 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,01939264 0,03101744 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,0204595 0,03270107 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,0204595 0,03267836 ! positive regulation of ossification GO:0045778 30 19 0,000 0,0204595 0,03265568 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,0204595 0,03263304 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,0204595 0,03261042 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,0204595 0,03258784 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,0204595 0,03256529 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,0204595 0,03254277 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,0204595 0,03252028 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,0204595 0,03249782 ! regeneration GO:0031099 32 19 0,000 0,0204595 0,03247539 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,0204595 0,03245299 ! response to alkaloid GO:0043279 32 19 0,000 0,0204595 0,03243063 ! sensory perception of taste GO:0050909 23 19 0,000 0,0204595 0,03240829 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,0204595 0,03238599 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,0204595 0,03236371 ! smooth muscle contraction GO:0006939 36 19 0,000 0,0204595 0,03234147 ! peroxisome organization GO:0007031 29 19 0,000 0,0204595 0,03231926 ! digestive system process GO:0022600 30 19 0,000 0,0204595 0,03229708 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,0204595 0,03227493 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,0204595 0,0322528 ! response to vitamin A GO:0033189 26 19 0,000 0,0204595 0,03223071 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,0204595 0,03220865 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,0204595 0,03218662 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,0204595 0,03216462 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,0204595 0,03214265 ! response to starvation GO:0042594 30 19 0,000 0,0204595 0,03212071 ! sex determination GO:0007530 29 19 0,000 0,0204595 0,0320988 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,0204595 0,03207692 ! plasma membrane fusion GO:0045026 23 19 0,000 0,0204595 0,03205507 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,0204595 0,03203325 ! cytolysis GO:0019835 20 19 0,000 0,0204595 0,03201146 ! renal system process GO:0003014 35 19 0,000 0,0204595 0,03198969 ! vasodilation GO:0042311 33 19 0,000 0,0204595 0,03196796 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,0204595 0,03194626 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,0204595 0,03192459 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,0204595 0,03190294 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,0204595 0,03188133 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,0204595 0,03185974 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,0204595 0,03183819 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,0204595 0,03181666 ! sarcomere organization GO:0045214 23 19 0,000 0,0204595 0,03179516 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,0204595 0,03177369 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,0204595 0,03175225 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,0204595 0,03173084 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,0204595 0,03170946 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,0204595 0,03168811 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,0204595 0,03166678 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,0204595 0,03164549 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,0204595 0,03162422 ! protein stabilization GO:0050821 26 19 0,000 0,0204595 0,03160298 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,02152525 0,0332269 ! iron ion transport GO:0006826 37 20 0,000 0,02152525 0,03320461 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,02152525 0,03318236 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,02152525 0,03316013 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,02152525 0,03313794 ! response to vitamin GO:0033273 29 20 0,000 0,02152525 0,03311577 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,02152525 0,03309363 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,02152525 0,03307153 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,02152525 0,03304945 ! spinal cord development GO:0021510 31 20 0,000 0,02152525 0,0330274 ! response to ethanol GO:0045471 37 20 0,000 0,02152525 0,03300538 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,02152525 0,0329834 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,02152525 0,03296144 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,02152525 0,0329395 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,02152525 0,0329176 ! chromosome condensation GO:0030261 31 20 0,000 0,02152525 0,03289573 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,02152525 0,03287389 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,02152525 0,03285207 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,02152525 0,03283029 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,02152525 0,03280853 ! pallium development GO:0021543 38 20 0,000 0,02152525 0,03278681 ! DNA modification GO:0006304 28 20 0,000 0,02152525 0,03276511 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,02152525 0,03274344 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,02152525 0,0327218 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,02152525 0,03270018 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,02152525 0,0326786 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,02152525 0,03265704 ! collagen catabolic process GO:0030574 25 20 0,000 0,02152525 0,03263551 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,02152525 0,03261402 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,02152525 0,03259255 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,02152525 0,0325711 ! alditol metabolic process GO:0019400 24 20 0,000 0,02152525 0,03254969 ! actin filament-based movement GO:0030048 34 20 0,000 0,02152525 0,0325283 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,02258991 0,03411476 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,02258991 0,03409238 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,02258991 0,03407002 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,02258991 0,0340477 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,02258991 0,0340254 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,02258991 0,03400313 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,02258991 0,03398089 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,02258991 0,03395868 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,02258991 0,0339365 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,02258991 0,03391435 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,02258991 0,03389223 ! protein amino acid acylation GO:0043543 37 21 0,000 0,02258991 0,03387013 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,02258991 0,03384807 ! vesicle docking GO:0048278 27 21 0,000 0,02258991 0,03382603 ! phototransduction GO:0007602 25 21 0,000 0,02258991 0,03380402 ! dendrite development GO:0016358 35 21 0,000 0,02258991 0,03378204 ! visual behavior GO:0007632 39 21 0,000 0,02258991 0,03376009 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,02258991 0,03373817 ! ovarian follicle development GO:0001541 30 21 0,000 0,02258991 0,03371628 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,02258991 0,03369441 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,02258991 0,03367258 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,02258991 0,03365077 ! cell aging GO:0007569 32 21 0,000 0,02258991 0,03362899 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,02258991 0,03360723 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,02258991 0,03358551 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,02258991 0,03356381 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,02258991 0,03354215 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,02258991 0,03352051 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,02258991 0,03349889 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,02258991 0,03347731 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,02258991 0,03345575 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,02258991 0,03343422 ! fatty acid transport GO:0015908 30 21 0,000 0,02258991 0,03341272 ! immunoglobulin production GO:0002377 33 21 0,000 0,02258991 0,03339125 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,02258991 0,0333698 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,02258991 0,03334839 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,02258991 0,03332699 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,02258991 0,03330563 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,02258991 0,03328429 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,02258991 0,03326299 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,02258991 0,0332417 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,02258991 0,03322045 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,02258991 0,03319922 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,02258991 0,03317802 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,02258991 0,03315685 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,02258991 0,0331357 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,02258991 0,03311459 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,02258991 0,03309349 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,02365346 0,03462952 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,02365346 0,03460749 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,02365346 0,03458549 ! viral genome replication GO:0019079 29 22 0,000 0,02365346 0,03456351 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,02365346 0,03454157 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,02365346 0,03451965 ! leukocyte adhesion GO:0007159 38 22 0,000 0,02365346 0,03449776 ! molting cycle process GO:0022404 40 22 0,000 0,02365346 0,0344759 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,02365346 0,03445406 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,02365346 0,03443226 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,02365346 0,03441048 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,02365346 0,03438873 ! vasculogenesis GO:0001570 33 22 0,000 0,02365346 0,034367 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,02365346 0,03434531 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,02365346 0,03432364 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,02365346 0,034302 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,02365346 0,03428038 ! lysosome organization GO:0007040 37 22 0,000 0,02365346 0,0342588 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,02365346 0,03423724 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,02365346 0,0342157 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,02365346 0,0341942 ! regulation of behavior GO:0050795 38 22 0,000 0,02365346 0,03417272 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,02365346 0,03415127 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,02365346 0,03412984 ! membrane depolarization GO:0051899 35 22 0,000 0,02365346 0,03410844 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,02365346 0,03408707 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,02365346 0,03406573 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,02365346 0,03404441 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,02365346 0,03402312 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,02365346 0,03400186 ! blastocyst development GO:0001824 37 22 0,000 0,02365346 0,03398062 ! neural tube closure GO:0001843 33 22 0,000 0,02365346 0,03395941 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,02365346 0,03393822 ! protein tetramerization GO:0051262 39 22 0,000 0,02365346 0,03391706 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,02471593 0,03541846 ! neuron fate commitment GO:0048663 32 23 0,000 0,02471593 0,03539641 ! embryonic pattern specification GO:0009880 31 23 0,000 0,02471593 0,03537438 ! myelination GO:0042552 35 23 0,000 0,02471593 0,03535238 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,02471593 0,03533041 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,02471593 0,03530847 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,02471593 0,03528655 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,02471593 0,03526466 ! vesicle targeting GO:0006903 32 23 0,000 0,02471593 0,0352428 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,02471593 0,03522096 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,02471593 0,03519915 ! osteoblast differentiation GO:0001649 40 23 0,000 0,02471593 0,03517737 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,02471593 0,03515562 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,02471593 0,03513389 ! interaction with host GO:0051701 37 23 0,000 0,02471593 0,03511219 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,02471593 0,03509051 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,02471593 0,03506887 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,02471593 0,03504724 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,02471593 0,03502565 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,02471593 0,03500408 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,02471593 0,03498254 ! cell fate determination GO:0001709 45 23 0,000 0,02471593 0,03496103 ! pentose metabolic process GO:0019321 31 23 0,000 0,02471593 0,03493954 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,02471593 0,03491808 ! spermatid development GO:0007286 33 23 0,000 0,02471593 0,03489664 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,02471593 0,03487523 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,02471593 0,03485385 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,02471593 0,03483249 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,02471593 0,03481116 ! telomere organization GO:0032200 32 23 0,000 0,02471593 0,03478986 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,02471593 0,03476858 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,02471593 0,03474733 ! regulation of amine transport GO:0051952 38 23 0,000 0,02471593 0,0347261 ! liver development GO:0001889 40 23 0,000 0,02471593 0,0347049 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,02577729 0,03617314 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,02577729 0,03615108 ! initiation of viral infection GO:0019059 42 24 0,000 0,02577729 0,03612905 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,02577729 0,03610705 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,02577729 0,03608507 ! superoxide metabolic process GO:0006801 32 24 0,000 0,02577729 0,03606312 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,02577729 0,0360412 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,02577729 0,0360193 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,02577729 0,03599743 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,02577729 0,03597559 ! sperm motility GO:0030317 27 24 0,000 0,02577729 0,03595377 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,02577729 0,03593198 ! vacuole organization GO:0007033 39 24 0,000 0,02577729 0,03591022 ! receptor metabolic process GO:0043112 37 24 0,000 0,02577729 0,03588848 ! neural crest cell development GO:0014032 39 24 0,000 0,02577729 0,03586677 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,02577729 0,03584509 ! primary neural tube formation GO:0014020 35 24 0,000 0,02577729 0,03582343 ! negative regulation of cell development GO:0010721 56 24 0,000 0,02577729 0,0358018 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,02577729 0,03578019 ! base-excision repair GO:0006284 31 24 0,000 0,02577729 0,03575861 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,02577729 0,03573705 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,02577729 0,03571553 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,02577729 0,03569402 ! glutathione metabolic process GO:0006749 29 24 0,000 0,02577729 0,03567255 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,02577729 0,0356511 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,02577729 0,03562967 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,02577729 0,03560827 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,02683757 0,03705066 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,02683757 0,03702843 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,02683757 0,03700623 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,02683757 0,03698406 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,02683757 0,03696192 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,02683757 0,0369398 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,02683757 0,0369177 ! peptide transport GO:0015833 43 25 0,000 0,02683757 0,03689564 ! male gonad development GO:0008584 33 25 0,000 0,02683757 0,0368736 ! iron ion homeostasis GO:0055072 39 25 0,000 0,02683757 0,03685158 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,02683757 0,03682959 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,02683757 0,03680763 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,02683757 0,0367857 ! phospholipid transport GO:0015914 35 25 0,000 0,02683757 0,03676379 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,02683757 0,0367419 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,02683757 0,03672005 ! detection of light stimulus GO:0009583 30 25 0,000 0,02683757 0,03669822 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,02683757 0,03667641 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,02683757 0,03665463 ! leukocyte proliferation GO:0070661 39 25 0,000 0,02683757 0,03663288 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,02683757 0,03661115 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,02789674 0,0380335 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,02789674 0,03801097 ! translational initiation GO:0006413 43 26 0,000 0,02789674 0,03798846 ! regulation of pH GO:0006885 36 26 0,000 0,02789674 0,03796598 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,02789674 0,03794353 ! circadian rhythm GO:0007623 42 26 0,000 0,02789674 0,03792111 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,02789674 0,03789871 ! post-embryonic development GO:0009791 42 26 0,000 0,02789674 0,03787633 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,02789674 0,03785399 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,02789674 0,03783167 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,02789674 0,03780938 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,02789674 0,03778711 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,02789674 0,03776487 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,02789674 0,03774265 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,02789674 0,03772047 ! regulation of coagulation GO:0050818 39 26 0,000 0,02789674 0,0376983 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,02895483 0,03910517 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,02895483 0,03908222 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,02895483 0,0390593 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,02895483 0,03903641 ! membrane docking GO:0022406 39 27 0,000 0,02895483 0,03901354 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,02895483 0,0389907 ! catechol metabolic process GO:0009712 43 27 0,000 0,02895483 0,03896788 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,02895483 0,03894509 ! acute-phase response GO:0006953 42 27 0,000 0,02895483 0,03892233 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,02895483 0,0388996 ! myofibril assembly GO:0030239 36 27 0,000 0,02895483 0,03887689 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,02895483 0,03885421 ! response to ionizing radiation GO:0010212 47 27 0,000 0,02895483 0,03883155 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,02895483 0,03880892 ! natural killer cell activation GO:0030101 35 27 0,000 0,02895483 0,03878632 ! lipid oxidation GO:0034440 38 27 0,000 0,02895483 0,03876374 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,02895483 0,03874119 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,02895483 0,03871867 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,02895483 0,03869617 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,02895483 0,0386737 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,02895483 0,03865125 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,02895483 0,03862883 ! gene silencing GO:0016458 41 27 0,000 0,02895483 0,03860644 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,03001183 0,03999258 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,03001183 0,03996943 ! phenol metabolic process GO:0018958 44 28 0,000 0,03001183 0,0399463 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,03001183 0,03992319 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,03001183 0,03990012 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,03001183 0,03987707 ! cell junction assembly GO:0034329 56 28 0,000 0,03001183 0,03985404 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,03001183 0,03983104 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,03001183 0,03980807 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,03001183 0,03978513 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,03001183 0,03976221 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,03001183 0,03973932 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,03001183 0,03971646 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,03001183 0,03969362 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,03001183 0,0396708 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,03001183 0,03964802 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,03001183 0,03962526 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,03001183 0,03960252 ! mesoderm formation GO:0001707 46 28 0,000 0,03001183 0,03957982 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,03001183 0,03955713 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,03001183 0,03953448 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,03001183 0,03951185 ! ensheathment of neurons GO:0007272 43 28 0,000 0,03001183 0,03948925 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,03001183 0,03946667 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,03001183 0,03944411 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,03001183 0,03942159 ! neural tube formation GO:0001841 41 28 0,000 0,03001183 0,03939909 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,03001183 0,03937661 ! placenta development GO:0001890 37 28 0,000 0,03001183 0,03935416 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,03106773 0,04071555 ! regulation of innate immune response GO:0045088 38 29 0,000 0,03106773 0,04069236 ! ovulation cycle process GO:0022602 41 29 0,000 0,03106773 0,0406692 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,03106773 0,04064607 ! protein targeting to membrane GO:0006612 53 29 0,000 0,03106773 0,04062296 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,03106773 0,04059988 ! mismatch repair GO:0006298 34 29 0,000 0,03106773 0,04057682 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,03106773 0,04055379 ! muscle cell development GO:0055001 38 29 0,000 0,03106773 0,04053079 ! formation of primary germ layer GO:0001704 48 29 0,000 0,03106773 0,04050781 ! telencephalon development GO:0021537 52 29 0,000 0,03106773 0,04048486 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,03106773 0,04046194 ! eye morphogenesis GO:0048592 51 29 0,000 0,03106773 0,04043904 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,03106773 0,04041617 ! tissue homeostasis GO:0001894 42 29 0,000 0,03106773 0,04039332 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,03212255 0,04174116 ! collagen metabolic process GO:0032963 40 30 0,000 0,03212255 0,0417176 ! organic anion transport GO:0015711 51 30 0,000 0,03212255 0,04169405 ! cholesterol transport GO:0030301 46 30 0,000 0,03212255 0,04167054 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,03212255 0,04164705 ! spliceosome assembly GO:0000245 49 30 0,000 0,03212255 0,04162358 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,03212255 0,04160015 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,03212255 0,04157674 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,03212255 0,04155335 ! ceramide metabolic process GO:0006672 43 30 0,000 0,03212255 0,04153 ! ovulation cycle GO:0042698 43 30 0,000 0,03212255 0,04150666 ! hindbrain development GO:0030902 45 30 0,000 0,03212255 0,04148336 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,03212255 0,04146008 ! adult locomotory behavior GO:0008344 47 30 0,000 0,03212255 0,04143683 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,03212255 0,0414136 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,03212255 0,0413904 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,03212255 0,04136722 ! response to heat GO:0009408 41 30 0,000 0,03212255 0,04134407 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,03212255 0,04132095 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,03212255 0,04129785 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,03317628 0,04262874 ! negative regulation of secretion GO:0051048 49 31 0,000 0,03317628 0,04260493 ! mammary gland development GO:0030879 57 31 0,000 0,03317628 0,04258116 ! glial cell differentiation GO:0010001 55 31 0,000 0,03317628 0,04255741 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,03317628 0,04253369 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,03317628 0,04250999 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,03317628 0,04248632 ! odontogenesis GO:0042476 50 31 0,000 0,03317628 0,04246268 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,03317628 0,04243906 ! segmentation GO:0035282 41 31 0,000 0,03317628 0,04241547 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,03317628 0,04239191 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,03317628 0,04236837 ! metanephros development GO:0001656 58 31 0,000 0,03317628 0,04234486 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,03317628 0,04232137 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,03317628 0,04229791 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,03317628 0,04227448 ! cell fate specification GO:0001708 37 31 0,000 0,03317628 0,04225107 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,03317628 0,04222769 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,03317628 0,04220433 ! RNA modification GO:0009451 40 31 0,000 0,03317628 0,042181 ! regulation of muscle development GO:0048634 48 32 0,000 0,03422892 0,04349531 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,03422892 0,04347129 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,03422892 0,0434473 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,03422892 0,04342334 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,03422892 0,0433994 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,03422892 0,04337549 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,03422892 0,0433516 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,03422892 0,04332775 ! peripheral nervous system development GO:0007422 53 32 0,000 0,03422892 0,04330391 ! regulation of protein stability GO:0031647 48 32 0,000 0,03422892 0,04328011 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,03422892 0,04325633 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,03422892 0,04323257 ! cytokine production GO:0001816 44 32 0,000 0,03422892 0,04320884 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,03422892 0,04318514 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,03422892 0,04316147 ! vesicle localization GO:0051648 47 32 0,000 0,03422892 0,04313782 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,03528047 0,04443871 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,03528047 0,04441439 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,03528047 0,04439009 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,03528047 0,04436582 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,03528047 0,04434158 ! sister chromatid segregation GO:0000819 46 33 0,000 0,03528047 0,04431736 ! ear morphogenesis GO:0042471 42 33 0,000 0,03528047 0,04429317 ! actomyosin structure organization GO:0031032 43 33 0,000 0,03528047 0,04426901 ! cell junction organization GO:0034330 63 33 0,000 0,03528047 0,04424487 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,03528047 0,04422076 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,03528047 0,04419667 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,03528047 0,04417261 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,03528047 0,04414858 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,03528047 0,04412457 ! female gonad development GO:0008585 49 33 0,000 0,03528047 0,04410059 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,03528047 0,04407664 ! positive regulation of cell development GO:0010720 54 33 0,000 0,03528047 0,04405271 ! lipid homeostasis GO:0055088 55 33 0,000 0,03528047 0,04402881 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,03528047 0,04400493 ! regulation of proteolysis GO:0030162 50 33 0,000 0,03528047 0,04398108 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,03528047 0,04395725 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,03528047 0,04393346 ! cytokinesis GO:0000910 52 33 0,000 0,03528047 0,04390968 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,03528047 0,04388593 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,03633095 0,0451682 ! mRNA catabolic process GO:0006402 48 34 0,000 0,03633095 0,0451438 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,03633095 0,04511943 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,03633095 0,04509508 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,03633095 0,04507075 ! feeding behavior GO:0007631 45 34 0,000 0,03633095 0,04504646 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,03633095 0,04502218 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,03633095 0,04499794 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,03633095 0,04497372 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,03633095 0,04494953 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,03633095 0,04492536 ! neuron migration GO:0001764 46 34 0,000 0,03633095 0,04490122 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,03633095 0,04487711 ! female gamete generation GO:0007292 43 34 0,000 0,03633095 0,04485302 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,03633095 0,04482896 ! polyol metabolic process GO:0019751 44 34 0,000 0,03633095 0,04480492 ! aerobic respiration GO:0009060 47 34 0,000 0,03633095 0,04478091 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,03633095 0,04475692 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,03633095 0,04473296 ! embryonic organ development GO:0048568 45 34 0,000 0,03633095 0,04470903 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,03633095 0,04468512 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,03738033 0,04595124 ! Notch signaling pathway GO:0007219 56 35 0,000 0,03738033 0,04592669 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,03738033 0,04590217 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,03738033 0,04587768 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,03738033 0,04585321 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,03738033 0,04582877 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,03738033 0,04580435 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,03738033 0,04577996 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,03738033 0,0457556 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,03738033 0,04573126 ! glycogen metabolic process GO:0005977 48 35 0,000 0,03738033 0,04570695 ! pigment metabolic process GO:0042440 61 35 0,000 0,03738033 0,04568266 ! protein homooligomerization GO:0051260 52 35 0,000 0,03738033 0,0456584 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,03842864 0,04691394 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,03842864 0,04688905 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,03842864 0,04686419 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,03842864 0,04683936 ! negative regulation of binding GO:0051100 58 36 0,000 0,03842864 0,04681455 ! organic ether metabolic process GO:0018904 46 36 0,000 0,03842864 0,04678977 ! tissue remodeling GO:0048771 62 36 0,000 0,03842864 0,04676501 ! neural tube development GO:0021915 50 36 0,000 0,03842864 0,04674028 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,03842864 0,04671557 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,03842864 0,0466909 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,03842864 0,04666624 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,03842864 0,04664162 ! glucan metabolic process GO:0044042 49 36 0,000 0,03842864 0,04661702 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,03947586 0,04786214 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,03947586 0,04783692 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,03947586 0,04781173 ! learning GO:0007612 67 37 0,000 0,03947586 0,04778657 ! ion transmembrane transport GO:0034220 56 37 0,000 0,03947586 0,04776143 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,03947586 0,04773632 ! regulation of protein secretion GO:0050708 51 37 0,000 0,03947586 0,04771124 ! amino acid activation GO:0043038 52 37 0,000 0,03947586 0,04768618 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,03947586 0,04766114 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,040522 0,04889854 ! gliogenesis GO:0042063 71 38 0,000 0,040522 0,04887289 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,040522 0,04884728 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,040522 0,04882169 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,040522 0,04879613 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,040522 0,0487706 ! phagocytosis GO:0006909 60 38 0,000 0,040522 0,04874509 ! mesenchymal cell development GO:0014031 64 38 0,000 0,040522 0,04871961 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,040522 0,04869415 ! maintenance of location in cell GO:0051651 69 38 0,000 0,040522 0,04866873 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,04156707 0,04989784 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,04156707 0,04987181 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,04156707 0,04984581 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,04156707 0,04981983 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,04156707 0,04979388 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,04156707 0,04976796 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,04156707 0,04974207 ! male sex differentiation GO:0046661 53 39 0,000 0,04156707 0,0497162 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,04156707 0,04969036 ! chromatin remodeling GO:0006338 68 39 0,000 0,04156707 0,04966455 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,04156707 0,04963876 ! JNK cascade GO:0007254 54 39 0,000 0,04156707 0,049613 ! developmental growth GO:0048589 62 39 0,000 0,04156707 0,04958727 ! cell growth GO:0016049 61 39 0,000 0,04156707 0,04956156 ! synapse organization GO:0050808 55 39 0,000 0,04156707 0,04953588 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,04261105 0,05075371 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,04261105 0,05072744 ! regulation of tube size GO:0035150 60 40 0,000 0,04261105 0,0507012 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,04261105 0,05067498 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,04261105 0,0506488 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,04261105 0,05062263 ! peptide metabolic process GO:0006518 56 40 0,000 0,04261105 0,0505965 ! inner ear development GO:0048839 57 40 0,000 0,04261105 0,05057039 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,04261105 0,05054431 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,04261105 0,05051826 ! double-strand break repair GO:0006302 67 40 0,000 0,04261105 0,05049223 ! B cell differentiation GO:0030183 62 40 0,000 0,04261105 0,05046623 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,04261105 0,05044026 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,04261105 0,05041431 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,04261105 0,05038839 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,04365396 0,05159512 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,04365396 0,05156862 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,04365396 0,05154215 ! glucose transport GO:0015758 52 41 0,000 0,04365396 0,0515157 ! endosome transport GO:0016197 71 41 0,000 0,04365396 0,05148929 ! striated muscle contraction GO:0006941 62 41 0,000 0,04365396 0,05146289 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,04365396 0,05143653 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,04365396 0,05141019 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,04365396 0,05138388 ! biopolymer methylation GO:0043414 62 41 0,000 0,04365396 0,0513576 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,04365396 0,05133134 ! mitochondrial transport GO:0006839 60 42 0,000 0,04469579 0,05252954 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,04469579 0,05250272 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,04469579 0,05247591 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,04469579 0,05244914 ! cellular component disassembly GO:0022411 64 42 0,000 0,04469579 0,0524224 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,04469579 0,05239568 ! hexose transport GO:0008645 54 42 0,000 0,04469579 0,05236898 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,04469579 0,05234232 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,04469579 0,05231568 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,04469579 0,05228907 ! excretion GO:0007588 63 42 0,000 0,04469579 0,05226249 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,04469579 0,05223593 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,04469579 0,0522094 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,04469579 0,0521829 ! regulation of cell shape GO:0008360 78 42 0,000 0,04469579 0,05215643 ! positive regulation of binding GO:0051099 59 43 0,000 0,04573655 0,05334384 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,04573655 0,0533168 ! leukocyte migration GO:0050900 60 43 0,000 0,04573655 0,0532898 ! neuromuscular process GO:0050905 79 43 0,000 0,04573655 0,05326281 ! activation of caspase activity GO:0006919 65 43 0,000 0,04573655 0,05323586 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,04573655 0,05320893 ! tRNA processing GO:0008033 49 43 0,000 0,04573655 0,05318203 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,04573655 0,05315516 ! vesicle organization GO:0016050 79 43 0,000 0,04573655 0,05312831 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,04573655 0,05310149 ! methylation GO:0032259 64 43 0,000 0,04573655 0,0530747 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,04677623 0,05425382 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,04677623 0,05422647 ! glycolysis GO:0006096 53 44 0,000 0,04677623 0,05419916 ! regulation of action potential GO:0001508 71 44 0,000 0,04677623 0,05417186 ! regulation of ion transport GO:0043269 57 44 0,000 0,04677623 0,0541446 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,04677623 0,05411737 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,04677623 0,05409016 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,04677623 0,05406298 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,04677623 0,05403582 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,04677623 0,0540087 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,04677623 0,0539816 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,04677623 0,05395453 ! RNA catabolic process GO:0006401 64 45 0,000 0,04781484 0,05512487 ! positive regulation of defense response GO:0031349 59 45 0,000 0,04781484 0,05509726 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,04781484 0,05506967 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,04781484 0,0550421 ! cell recognition GO:0008037 58 45 0,000 0,04781484 0,05501457 ! cell maturation GO:0048469 60 45 0,000 0,04781484 0,05498706 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,04781484 0,05495958 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,04885237 0,0561241 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,04885237 0,05609608 ! cell redox homeostasis GO:0045454 63 46 0,000 0,04885237 0,05606809 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,04885237 0,05604013 ! regulation of ossification GO:0030278 71 46 0,000 0,04885237 0,05601219 ! histone modification GO:0016570 68 46 0,000 0,04885237 0,05598428 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,04885237 0,0559564 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,04988884 0,05711514 ! viral infectious cycle GO:0019058 71 47 0,000 0,04988884 0,05708673 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,04988884 0,05705834 ! endocrine system development GO:0035270 83 47 0,000 0,04988884 0,05702998 ! covalent chromatin modification GO:0016569 75 47 0,000 0,04988884 0,05700165 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,04988884 0,05697335 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,04988884 0,05694507 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,04988884 0,05691683 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,04988884 0,05688861 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,04988884 0,05686042 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,04988884 0,05683226 ! chloride transport GO:0006821 67 48 0,000 0,05092423 0,05798304 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,05092423 0,05795435 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,05092423 0,05792568 ! response to temperature stimulus GO:0009266 62 48 0,000 0,05092423 0,05789705 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,05092423 0,05786845 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,05092423 0,05783987 ! gastrulation GO:0007369 73 48 0,000 0,05092423 0,05781132 ! heart morphogenesis GO:0003007 65 48 0,000 0,05092423 0,0577828 ! regulation of DNA replication GO:0006275 75 48 0,000 0,05092423 0,05775431 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,05092423 0,05772584 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,05092423 0,05769741 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,05092423 0,057669 ! regulation of endocytosis GO:0030100 63 48 0,000 0,05092423 0,05764062 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,05092423 0,05761226 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,05092423 0,05758394 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,05195856 0,05872466 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,05195856 0,05869582 ! sensory perception of smell GO:0007608 61 49 0,000 0,05195856 0,058667 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,05195856 0,05863822 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,05195856 0,05860946 ! RNA elongation GO:0006354 62 49 0,000 0,05195856 0,05858073 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,05195856 0,05855203 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,05195856 0,05852335 ! germ cell development GO:0007281 68 49 0,000 0,05195856 0,05849471 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,05195856 0,05846609 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,05195856 0,0584375 ! cartilage development GO:0051216 70 49 0,000 0,05195856 0,05840894 ! maintenance of location GO:0051235 84 49 0,000 0,05195856 0,0583804 ! regulation of actin filament length GO:0030832 72 50 0,000 0,05299182 0,05951229 ! ear development GO:0043583 72 50 0,000 0,05299182 0,05948325 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,05299182 0,05945423 ! membrane fusion GO:0006944 80 50 0,000 0,05299182 0,05942524 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,05299182 0,05939628 ! lipid modification GO:0030258 73 50 0,000 0,05299182 0,05936735 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,05299182 0,05933845 ! proton transport GO:0015992 75 50 0,000 0,05299182 0,05930958 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,05299182 0,05928073 ! positive regulation of secretion GO:0051047 71 51 0,000 0,05402401 0,06040604 ! hydrogen transport GO:0006818 77 51 0,000 0,05402401 0,06037668 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,05402401 0,06034736 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,05402401 0,06031807 ! positive regulation of cell migration GO:0030335 92 51 0,000 0,05402401 0,0602888 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,05402401 0,06025956 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,05402401 0,06023035 ! adult behavior GO:0030534 80 51 0,000 0,05402401 0,06020117 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,05402401 0,06017202 ! transition metal ion transport GO:0000041 74 52 0,000 0,05505513 0,06129081 ! regulation of cellular component size GO:0032535 74 52 0,000 0,05505513 0,06126115 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,05505513 0,06123153 ! aging GO:0007568 79 52 0,000 0,05505513 0,06120194 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,05505513 0,06117237 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,05505513 0,06114283 ! establishment of organelle localization GO:0051656 85 52 0,000 0,05505513 0,06111332 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,05608519 0,0622267 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,05608519 0,06219669 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,05608519 0,06216672 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,05608519 0,06213677 ! kidney development GO:0001822 90 53 0,000 0,05608519 0,06210686 ! single fertilization GO:0007338 59 53 0,000 0,05608519 0,06207697 ! cell projection assembly GO:0030031 76 53 0,000 0,05608519 0,06204711 ! amino acid transport GO:0006865 84 54 0,000 0,05711419 0,06315511 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,05711419 0,06312476 ! regulation of mitosis GO:0007088 84 54 0,000 0,05711419 0,06309445 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,05711419 0,06306416 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,05711419 0,06303389 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,05711419 0,06300366 ! DNA catabolic process GO:0006308 67 54 0,000 0,05711419 0,06297346 ! detection of external stimulus GO:0009581 66 54 0,000 0,05711419 0,06294328 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,05711419 0,06291314 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,05711419 0,06288302 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,05711419 0,06285294 ! exocytosis GO:0006887 74 55 0,000 0,05814212 0,06395355 ! mesoderm development GO:0007498 76 55 0,000 0,05814212 0,06392298 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,05814212 0,06389244 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,05814212 0,06386193 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,059169 0,0649588 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,059169 0,06492781 ! positive regulation of cell motion GO:0051272 99 56 0,000 0,059169 0,06489685 ! carbohydrate transport GO:0008643 74 57 0,000 0,06019481 0,06599049 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,06019481 0,06595905 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,06019481 0,06592765 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,06019481 0,06589627 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,06019481 0,06586492 ! camera-type eye development GO:0043010 88 57 0,000 0,06019481 0,0658336 ! secondary metabolic process GO:0019748 84 57 0,000 0,06019481 0,06580231 ! developmental maturation GO:0021700 75 57 0,000 0,06019481 0,06577105 ! gonad development GO:0008406 79 57 0,000 0,06019481 0,06573982 ! viral reproductive process GO:0022415 87 58 0,000 0,06121956 0,06682723 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,06121956 0,06679553 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,06121956 0,06676386 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,06121956 0,06673222 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,06224325 0,06781595 ! activation of MAPK activity GO:0000187 84 59 0,000 0,06224325 0,06778384 ! lung development GO:0030324 94 59 0,000 0,06224325 0,06775176 ! actin filament organization GO:0007015 95 59 0,000 0,06224325 0,06771972 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,06224325 0,0676877 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,06224325 0,06765571 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,06326589 0,06873478 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,06326589 0,06870233 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,06326589 0,06866991 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,06326589 0,06863752 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,06326589 0,06860516 ! regulation of heart contraction GO:0008016 91 60 0,000 0,06326589 0,06857283 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,06326589 0,06854053 ! fertilization GO:0009566 68 60 0,000 0,06326589 0,06850826 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,06326589 0,06847602 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,06428747 0,069549 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,06428747 0,0695163 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,06428747 0,06948363 ! urogenital system development GO:0001655 101 61 0,000 0,06428747 0,069451 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,06428747 0,06941839 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,06428747 0,06938581 ! extracellular matrix organization GO:0030198 103 61 0,000 0,06428747 0,06935327 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,06428747 0,06932076 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,06530799 0,07038818 ! neurotransmitter transport GO:0006836 81 62 0,000 0,06530799 0,07035521 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,06530799 0,07032227 ! respiratory tube development GO:0030323 99 62 0,000 0,06530799 0,07028937 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,06530799 0,07025649 ! organelle localization GO:0051640 96 62 0,000 0,06530799 0,07022364 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,06632746 0,07128652 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,06632746 0,07125322 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,06632746 0,07121996 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,06632746 0,07118673 ! viral reproduction GO:0016032 92 63 0,000 0,06632746 0,07115352 ! regulation of lipase activity GO:0060191 109 63 0,000 0,06632746 0,07112035 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,06734587 0,07217871 ! appendage morphogenesis GO:0035107 93 64 0,000 0,06734587 0,07214509 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,06734587 0,0721115 ! hexose catabolic process GO:0019320 82 64 0,000 0,06734587 0,07207795 ! respiratory system development GO:0060541 100 64 0,000 0,06734587 0,07204442 ! adaptive immune response GO:0002250 94 64 0,000 0,06734587 0,07201093 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,06836324 0,0730648 ! appendage development GO:0048736 94 65 0,000 0,06836324 0,07303086 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,06836324 0,07299696 ! defense response to bacterium GO:0042742 73 65 0,000 0,06836324 0,07296308 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,06836324 0,07292924 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,06836324 0,07289543 ! activation of immune response GO:0002253 83 65 0,000 0,06836324 0,07286165 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,06937955 0,07391059 ! antigen processing and presentation GO:0019882 96 66 0,000 0,06937955 0,07387637 ! axon guidance GO:0007411 99 66 0,000 0,06937955 0,07384218 ! regulation of immune effector process GO:0002697 101 66 0,000 0,06937955 0,07380803 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,07039481 0,07485347 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,07039481 0,07481888 ! acute inflammatory response GO:0002526 92 68 0,000 0,07140902 0,07586178 ! learning or memory GO:0007611 123 68 0,000 0,07140902 0,07582675 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,07140902 0,07579176 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,07140902 0,0757568 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,07140902 0,07572188 ! rhythmic process GO:0048511 105 68 0,000 0,07140902 0,07568698 ! inorganic anion transport GO:0015698 93 68 0,000 0,07140902 0,07565212 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,07242218 0,07669016 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,07242218 0,07665487 ! response to drug GO:0042493 108 69 0,000 0,07242218 0,07661961 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,0734343 0,07765466 ! humoral immune response GO:0006959 86 70 0,000 0,0734343 0,07761898 ! eye development GO:0001654 111 70 0,000 0,0734343 0,07758332 ! amine transport GO:0015837 101 70 0,000 0,0734343 0,0775477 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,0734343 0,07751211 ! regulation of catabolic process GO:0009894 106 70 0,000 0,0734343 0,07747656 ! muscle cell differentiation GO:0042692 104 71 0,000 0,07444537 0,07850727 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,07444537 0,07847129 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,07444537 0,07843534 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,07444537 0,07839943 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,07444537 0,07836355 ! response to hypoxia GO:0001666 132 72 0,000 0,0754554 0,0793904 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,0754554 0,0793541 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,0754554 0,07931783 ! negative regulation of transport GO:0051051 116 73 0,000 0,07646438 0,08034174 ! regulation of blood pressure GO:0008217 107 73 0,000 0,07646438 0,08030505 ! tube morphogenesis GO:0035239 118 73 0,000 0,07646438 0,0802684 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,07646438 0,08023178 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,07646438 0,0801952 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,07747231 0,08121528 ! response to oxygen levels GO:0070482 137 74 0,000 0,07747231 0,08117828 ! digestion GO:0007586 97 74 0,000 0,07747231 0,08114131 ! protein import into nucleus GO:0006606 118 74 0,000 0,07747231 0,08110438 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,07747231 0,08106748 ! blood coagulation GO:0007596 116 75 0,000 0,07847921 0,08208375 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 0,000 0,07847921 0,08204644 ! nuclear import GO:0051170 121 75 0,000 0,07847921 0,08200917 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,07847921 0,08197192 ! amine biosynthetic process GO:0009309 97 76 0,000 0,07948506 0,08298486 ! tRNA metabolic process GO:0006399 95 76 0,000 0,07948506 0,08294721 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,07948506 0,08290959 ! regulation of protein transport GO:0051223 114 76 0,000 0,07948506 0,082872 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,08048987 0,08388161 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,08048987 0,08384362 ! regulation of DNA binding GO:0051101 119 77 0,000 0,08048987 0,08380566 ! gland development GO:0048732 148 77 0,000 0,08048987 0,08376774 ! sex differentiation GO:0007548 105 77 0,000 0,08048987 0,08372986 ! protein ubiquitination GO:0016567 125 77 0,000 0,08048987 0,083692 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,08048987 0,08365419 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,08048987 0,0836164 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,08048987 0,08357865 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,08149365 0,08458276 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,08149365 0,08454461 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,08249639 0,0855463 ! cellular respiration GO:0045333 107 79 0,000 0,08249639 0,08550774 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,08249639 0,08546923 ! T cell activation GO:0042110 134 79 0,000 0,08249639 0,08543075 ! regulation of lyase activity GO:0051339 133 79 0,000 0,08249639 0,0853923 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,08249639 0,08535388 ! chromatin assembly GO:0031497 102 80 0,000 0,08349808 0,08635144 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,08349808 0,08631263 ! protein localization in nucleus GO:0034504 133 80 0,000 0,08349808 0,08627385 ! forebrain development GO:0030900 131 80 0,000 0,08349808 0,08623511 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,08449875 0,08722941 ! hemostasis GO:0007599 125 81 0,000 0,08449875 0,08719027 ! mRNA transport GO:0051028 121 81 0,000 0,08449875 0,08715117 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,08449875 0,08711211 ! regulation of neurological system process GO:0031644 122 81 0,000 0,08449875 0,08707308 ! vitamin metabolic process GO:0006766 103 81 0,000 0,08449875 0,08703409 ! ossification GO:0001503 134 82 0,000 0,08549837 0,08802429 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,08549837 0,0879849 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,08649697 0,08897273 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,08649697 0,08893296 ! regulation of defense response GO:0031347 117 84 0,000 0,08749453 0,08991842 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,08749453 0,08987826 ! sterol metabolic process GO:0016125 120 84 0,000 0,08749453 0,08983813 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,08849106 0,09082081 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,08849106 0,0907803 ! rRNA metabolic process GO:0016072 107 85 0,000 0,08849106 0,09073983 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 0,000 0,08849106 0,09069939 ! transcription initiation GO:0006352 118 85 0,000 0,08849106 0,09065899 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,08849106 0,09061863 ! regulation of protein localization GO:0032880 132 85 0,000 0,08849106 0,0905783 ! regulation of membrane potential GO:0042391 128 85 0,000 0,08849106 0,090538 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,08849106 0,09049775 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,08948656 0,09147515 ! nucleosome organization GO:0034728 114 87 0,000 0,09048102 0,09245062 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,09048102 0,09240957 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,09048102 0,09236855 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,09048102 0,09232757 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,09048102 0,09228663 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,09048102 0,09224572 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,09147446 0,09321722 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,09147446 0,09317593 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,09147446 0,09313469 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,09147446 0,09309348 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,09246687 0,09406183 ! reproductive developmental process GO:0003006 127 89 0,000 0,09246687 0,09402025 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,09246687 0,0939787 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,09246687 0,09393719 ! regulation of T cell activation GO:0050863 128 89 0,000 0,09246687 0,09389572 ! leukocyte differentiation GO:0002521 143 90 0,000 0,09345825 0,09486054 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,09345825 0,0948187 ! hormone metabolic process GO:0042445 121 90 0,000 0,09345825 0,09477689 ! ATP metabolic process GO:0046034 137 91 0,000 0,09444861 0,09573901 ! response to virus GO:0009615 122 91 0,000 0,09444861 0,09569683 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,09543794 0,09665666 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,09543794 0,09661412 ! cell fate commitment GO:0045165 141 92 0,000 0,09543794 0,09657161 ! positive regulation of immune response GO:0050778 121 92 0,000 0,09543794 0,09652914 ! DNA recombination GO:0006310 146 92 0,000 0,09543794 0,09648671 ! sulfur metabolic process GO:0006790 118 92 0,000 0,09543794 0,09644432 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,09642625 0,09740025 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,09642625 0,0973575 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,09642625 0,09731478 ! electron transport chain GO:0022900 123 94 0,000 0,09741354 0,09826804 ! response to oxidative stress GO:0006979 141 94 0,000 0,09741354 0,09822496 ! regulation of binding GO:0051098 151 95 0,000 0,0983998 0,09917596 ! angiogenesis GO:0001525 149 95 0,000 0,0983998 0,09913252 ! carboxylic acid transport GO:0046942 147 95 0,000 0,0983998 0,09908912 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,09938504 0,10003746 ! in utero embryonic development GO:0001701 147 96 0,000 0,09938504 0,0999937 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,09938504 0,09994998 ! protein maturation GO:0051604 129 96 0,000 0,09938504 0,09990629 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,10036926 0,1008516 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,10036926 0,10080756 ! calcium ion transport GO:0006816 167 99 0,000 0,10233465 0,10273667 ! extracellular structure organization GO:0043062 156 99 0,000 0,10233465 0,10269184 ! protein import GO:0017038 156 99 0,000 0,10233465 0,10264706 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,10331582 0,10358604 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,10331582 0,10354091 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,10331582 0,10349581 ! divalent metal ion transport GO:0070838 171 100 0,000 0,10331582 0,10345076 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,10331582 0,10340574 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,10331582 0,10336076 ! protein localization in organelle GO:0033365 161 100 0,000 0,10331582 0,10331582