pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a1/out-0.05-06-0.01-300-run-a1//th1-pval-1e-02-02-th2-pval-1e-01-11-th3-pval-1e-01-01-run-a1/go_data/5155-5-real-Sotiriou-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of protein ubiquitination GO:0031397 7 5 1,000 1,652E-05 0,03799068 ! positive regulation of Rho GTPase activity GO:0032321 9 5 1,000 1,652E-05 0,01899534 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 1,652E-05 0,01266356 ! photoreceptor cell development GO:0042461 10 6 1,000 2,476E-05 0,0142351 GO:0046530|photoreceptor cell differentiation, ! regulation of Rac protein signal transduction GO:0035020 8 6 1,000 2,476E-05 0,01138808 ! glycolysis GO:0006096 53 44 2,000 2,543E-05 9,75E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 3,463E-05 0,01137896 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 3,463E-05 9,957E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 3,463E-05 8,85E-03 ! regulation of focal adhesion formation GO:0051893 17 7 1,000 3,463E-05 7,965E-03 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 1,000 3,463E-05 7,241E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 3,975E-05 7,619E-03 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 1,000 4,614E-05 8,163E-03 GO:0046579|positive regulation of Ras protein signal transduction, ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 4,614E-05 7,58E-03 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 4,614E-05 7,075E-03 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 1,000 4,614E-05 6,632E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 4,614E-05 6,242E-03 ! glucose catabolic process GO:0006007 66 54 2,000 4,723E-05 6,034E-03 ! positive regulation of GTPase activity GO:0043547 21 9 1,000 5,927E-05 7,175E-03 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 1,000 5,927E-05 6,816E-03 ! regulation of stress fiber formation GO:0051492 20 9 1,000 5,927E-05 6,492E-03 ! substrate-bound cell migration GO:0006929 10 9 1,000 5,927E-05 6,197E-03 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 1,000 5,927E-05 5,927E-03 ! establishment of cell polarity GO:0030010 12 9 1,000 5,927E-05 5,68E-03 ! regulation of phosphatase activity GO:0010921 21 10 1,000 7,403E-05 6,811E-03 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 7,403E-05 6,549E-03 ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 7,403E-05 6,306E-03 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 7,403E-05 6,081E-03 ! regulation of actin filament bundle formation GO:0032231 21 10 1,000 7,403E-05 5,872E-03 ! hexose catabolic process GO:0019320 82 64 2,000 7,865E-05 6,03E-03 ! Golgi vesicle budding GO:0048194 17 11 1,000 9,041E-05 6,708E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 9,041E-05 6,498E-03 ! regulation of Rho GTPase activity GO:0032319 18 11 1,000 9,041E-05 6,301E-03 ! monosaccharide catabolic process GO:0046365 91 71 2,000 1,072E-04 7,255E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 1,084E-04 7,124E-03 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 1,492E-04 9,534E-03 ! negative regulation of blood coagulation GO:0030195 19 14 1,000 1,492E-04 9,277E-03 ! alcohol catabolic process GO:0046164 104 80 2,000 1,53E-04 9,259E-03 ! regulation of cell adhesion GO:0030155 159 83 2,000 1,706E-04 0,01006341 ! regulation of protein ubiquitination GO:0031396 19 15 1,000 1,721E-04 9,893E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 1,831E-04 0,0102726 ! cellular response to unfolded protein GO:0034620 19 16 1,000 1,965E-04 0,01075928 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of dephosphorylation GO:0035303 33 16 1,000 1,965E-04 0,01050906 ! negative regulation of translation GO:0017148 22 16 1,000 1,965E-04 0,01027022 ! membrane budding GO:0006900 29 17 1,000 2,225E-04 0,01137182 ! cell-cell junction organization GO:0045216 25 17 1,000 2,225E-04 0,0111246 ! negative regulation of coagulation GO:0050819 23 17 1,000 2,225E-04 0,01088791 ! carbohydrate catabolic process GO:0016052 121 93 2,000 2,389E-04 0,01144931 ! positive regulation of DNA replication GO:0045740 29 18 1,000 2,501E-04 0,01173954 ! visual learning GO:0008542 35 18 1,000 2,501E-04 0,01150475 ! response to light stimulus GO:0009416 153 96 2,000 2,624E-04 0,01183432 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 2,793E-04 0,01235381 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 2,793E-04 0,01212072 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 2,793E-04 0,01189626 ! Ras protein signal transduction GO:0007265 162 100 2,000 2,96E-04 0,01237656 ! positive regulation of locomotion GO:0040017 35 20 1,000 3,101E-04 0,0127358 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 1,000 3,425E-04 0,01381839 ! visual behavior GO:0007632 39 21 1,000 3,425E-04 0,01358014 ! cell aging GO:0007569 32 21 1,000 3,425E-04 0,01334997 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 3,425E-04 0,01312747 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 3,425E-04 0,01291226 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 3,764E-04 0,01396322 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 3,764E-04 0,01374158 GO:0010810|regulation of cell-substrate adhesion, ! regulation of behavior GO:0050795 38 22 1,000 3,764E-04 0,01352687 ! regulation of blood coagulation GO:0030193 34 22 1,000 3,764E-04 0,01331876 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 4,119E-04 0,01435471 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 4,119E-04 0,01414046 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 4,119E-04 0,01393251 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 4,49E-04 0,01496684 ! fat cell differentiation GO:0045444 37 24 1,000 4,49E-04 0,01475303 ! negative regulation of protein modification process GO:0031400 50 26 1,000 5,279E-04 0,01710016 ! regulation of coagulation GO:0050818 39 26 1,000 5,279E-04 0,01686266 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 5,696E-04 0,01794783 ! protein targeting to membrane GO:0006612 53 29 1,000 6,579E-04 0,02044688 ! eye morphogenesis GO:0048592 51 29 1,000 6,579E-04 0,02017426 ! spindle organization GO:0007051 37 30 1,000 7,043E-04 0,0213138 ! negative regulation of cell activation GO:0050866 44 30 1,000 7,043E-04 0,021037 ! meiosis I GO:0007127 52 32 1,000 8,018E-04 0,02364164 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 8,018E-04 0,02334238 ! RNA export from nucleus GO:0006405 44 33 1,000 8,528E-04 0,02451812 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 8,528E-04 0,02421542 ! cell junction organization GO:0034330 63 33 1,000 8,528E-04 0,02392011 ! establishment or maintenance of cell polarity GO:0007163 61 34 1,000 9,054E-04 0,02508884 ! keratinocyte differentiation GO:0030216 47 35 1,000 9,595E-04 0,02627158 ! learning GO:0007612 67 37 1,000 1,072E-03 0,0290141 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 1,131E-03 0,03024569 ! striated muscle cell differentiation GO:0051146 54 38 1,000 1,131E-03 0,02989804 ! cell growth GO:0016049 61 39 1,000 1,191E-03 0,03113113 ! response to calcium ion GO:0051592 58 40 1,000 1,253E-03 0,03237552 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 1,253E-03 0,03201579 ! epidermal cell differentiation GO:0009913 53 40 1,000 1,253E-03 0,03166397 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 1,447E-03 0,03617183 ! vesicle organization GO:0016050 79 43 1,000 1,447E-03 0,03578289 ! response to insulin stimulus GO:0032868 63 43 1,000 1,447E-03 0,03540222 ! negative regulation of cell migration GO:0030336 92 44 1,000 1,515E-03 0,03666832 ! positive regulation of cell cycle GO:0045787 77 45 1,000 1,584E-03 0,03794375 ! response to UV GO:0009411 75 46 1,000 1,654E-03 0,03922815 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 1,727E-03 0,04052115 ! regulation of DNA replication GO:0006275 75 48 1,000 1,8E-03 0,0418224 ! nuclear export GO:0051168 69 48 1,000 1,8E-03 0,04140418 ! positive regulation of cell migration GO:0030335 92 51 1,000 2,03E-03 0,04622563 ! negative regulation of cell motion GO:0051271 104 51 1,000 2,03E-03 0,04577243 ! aging GO:0007568 79 52 1,000 2,109E-03 0,04710351 ! cell projection assembly GO:0030031 76 53 1,000 2,19E-03 0,04844131 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 2,442E-03 0,05349223 ! positive regulation of cell motion GO:0051272 99 56 1,000 2,442E-03 0,05298759 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 2,529E-03 0,05435775 ! actin filament organization GO:0007015 95 59 1,000 2,707E-03 0,05764279 ! meiosis GO:0007126 96 61 1,000 2,89E-03 0,06098874 GO:0051327|M phase of meiotic cell cycle, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 2,89E-03 0,0604343 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 2,984E-03 0,06183678 ! meiotic cell cycle GO:0051321 97 62 1,000 2,984E-03 0,06128467 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 3,08E-03 0,06268381 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 3,176E-03 0,06408708 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 3,176E-03 0,0635298 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 3,275E-03 0,06492971 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 3,275E-03 0,06437475 ! regulation of actin filament-based process GO:0032970 99 66 1,000 3,374E-03 0,06577134 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 3,374E-03 0,06521864 ! learning or memory GO:0007611 123 68 1,000 3,578E-03 0,06857575 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 3,578E-03 0,06800901 ! positive regulation of ligase activity GO:0051351 99 69 1,000 3,682E-03 0,06940962 ! response to metal ion GO:0010038 103 70 1,000 3,787E-03 0,07081363 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 3,787E-03 0,07024255 ! eye development GO:0001654 111 70 1,000 3,787E-03 0,06968061 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 3,787E-03 0,06912759 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 3,894E-03 0,07051491 ! muscle cell differentiation GO:0042692 104 71 1,000 3,894E-03 0,06996401 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 3,894E-03 0,06942165 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 4,002E-03 0,07079934 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 1,000 4,002E-03 0,07025888 ! regulation of synaptic transmission GO:0050804 109 72 1,000 4,002E-03 0,06972662 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 4,111E-03 0,07109497 ! response to oxygen levels GO:0070482 137 74 1,000 4,222E-03 0,07246669 ! response to inorganic substance GO:0010035 115 75 1,000 4,334E-03 0,07384164 ! regulation of ligase activity GO:0051340 114 75 1,000 4,334E-03 0,07329869 ! response to unfolded protein GO:0006986 99 76 1,000 4,448E-03 0,07467065 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 4,563E-03 0,07604565 ! positive regulation of protein modification process GO:0031401 107 78 1,000 4,679E-03 0,07742358 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 4,916E-03 0,08076049 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 1,000 4,916E-03 0,08018772 ! response to protein stimulus GO:0051789 111 81 1,000 5,036E-03 0,0815737 ! regulation of neurological system process GO:0031644 122 81 1,000 5,036E-03 0,08100326 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 5,406E-03 0,08634146 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 5,532E-03 0,08774217 ! Golgi vesicle transport GO:0048193 138 85 1,000 5,532E-03 0,0871412 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 5,532E-03 0,0865484 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 5,659E-03 0,08794022 ! interphase GO:0051325 159 88 1,000 5,917E-03 0,09133875 ! establishment of RNA localization GO:0051236 128 88 1,000 5,917E-03 0,09072983 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! RNA localization GO:0006403 135 91 1,000 6,315E-03 0,0961851 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 6,562E-03 0,09928823 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 6,562E-03 0,09863929 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 6,562E-03 0,09799878 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 6,562E-03 0,09736653 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 6,562E-03 0,09674238 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 6,562E-03 0,09612619 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 6,562E-03 0,09551779 ! sleep GO:0030431 11 5 0,000 6,562E-03 0,09491705 ! negative regulation of bone resorption GO:0045779 10 5 0,000 6,562E-03 0,09432382 ! nucleotide-sugar transport GO:0015780 8 5 0,000 6,562E-03 0,09373796 ! regulation of interferon-beta production GO:0032648 5 5 0,000 6,562E-03 0,09315933 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 6,562E-03 0,0925878 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 6,562E-03 0,09202324 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 6,562E-03 0,09146552 ! tongue development GO:0043586 6 5 0,000 6,562E-03 0,09091453 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 6,562E-03 0,09037013 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 6,562E-03 0,08983221 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 6,562E-03 0,08930066 ! cobalt ion transport GO:0006824 9 5 0,000 6,562E-03 0,08877536 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 6,562E-03 0,08825621 ! SMAD protein complex assembly GO:0007183 9 5 0,000 6,562E-03 0,08774309 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 6,562E-03 0,0872359 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 6,562E-03 0,08673455 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 6,562E-03 0,08623892 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 6,562E-03 0,08574893 ! embryonic camera-type eye development GO:0031076 8 5 0,000 6,562E-03 0,08526447 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 6,562E-03 0,08478546 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 6,562E-03 0,0843118 ! adaptation of signaling pathway GO:0022401 7 5 0,000 6,562E-03 0,0838434 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 6,562E-03 0,08338017 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 6,562E-03 0,08292204 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 6,562E-03 0,08246892 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 6,562E-03 0,08202071 ! positive regulation of histone modification GO:0031058 5 5 0,000 6,562E-03 0,08157736 ! malate metabolic process GO:0006108 7 5 0,000 6,562E-03 0,08113877 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 6,562E-03 0,08070487 ! behavioral response to pain GO:0048266 7 5 0,000 6,562E-03 0,08027559 ! clathrin coat assembly GO:0048268 11 5 0,000 6,562E-03 0,07985085 ! phototransduction, visible light GO:0007603 6 5 0,000 6,562E-03 0,07943059 ! regulation of dopamine uptake GO:0051584 9 5 0,000 6,562E-03 0,07901472 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 6,562E-03 0,07860318 ! mating behavior GO:0007617 6 5 0,000 6,562E-03 0,07819591 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 6,562E-03 0,07779284 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 6,562E-03 0,0773939 ! rhythmic behavior GO:0007622 12 5 0,000 6,562E-03 0,07699904 ! copulation GO:0007620 7 5 0,000 6,562E-03 0,07660818 ! glial cell fate commitment GO:0021781 12 5 0,000 6,562E-03 0,07622127 ! protein maturation by protein folding GO:0022417 12 5 0,000 6,562E-03 0,07583825 ! embryonic hemopoiesis GO:0035162 10 5 0,000 6,562E-03 0,07545906 ! regulation of potassium ion transport GO:0043266 9 5 0,000 6,562E-03 0,07508364 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 6,562E-03 0,07471194 ! apoptotic cell clearance GO:0043277 13 5 0,000 6,562E-03 0,0743439 ! lipoprotein particle clearance GO:0034381 9 5 0,000 6,562E-03 0,07397947 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 6,562E-03 0,07361859 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 6,562E-03 0,07326122 ! response to protozoan GO:0001562 9 5 0,000 6,562E-03 0,0729073 ! positive regulation of glycolysis GO:0045821 11 5 0,000 6,562E-03 0,07255679 ! lymph vessel development GO:0001945 7 5 0,000 6,562E-03 0,07220962 ! endochondral ossification GO:0001958 12 5 0,000 6,562E-03 0,07186577 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 6,562E-03 0,07152517 ! parathyroid gland development GO:0060017 8 5 0,000 6,562E-03 0,07118779 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 6,562E-03 0,07085357 ! anagen GO:0042640 6 5 0,000 6,562E-03 0,07052248 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 6,562E-03 0,07019447 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 6,562E-03 0,0698695 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 6,562E-03 0,06954752 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 6,562E-03 0,06922849 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 6,562E-03 0,06891238 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 6,562E-03 0,06859914 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 6,562E-03 0,06828874 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 6,562E-03 0,06798113 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 6,562E-03 0,06767628 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 6,562E-03 0,06737416 ! cardiac muscle fiber development GO:0048739 7 5 0,000 6,562E-03 0,06707472 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 6,562E-03 0,06677793 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 6,562E-03 0,06648375 ! neutrophil mediated immunity GO:0002446 6 5 0,000 6,562E-03 0,06619216 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 6,562E-03 0,06590311 ! ovulation GO:0030728 6 5 0,000 6,562E-03 0,06561657 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 6,562E-03 0,06533252 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 6,562E-03 0,06505091 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 6,562E-03 0,06477172 ! response to pH GO:0009268 9 5 0,000 6,562E-03 0,06449492 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 6,562E-03 0,06422047 ! proline biosynthetic process GO:0006561 6 5 0,000 6,562E-03 0,06394835 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 6,562E-03 0,06367853 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 6,562E-03 0,06341097 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 6,562E-03 0,06314565 ! polyol catabolic process GO:0046174 7 5 0,000 6,562E-03 0,06288255 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 6,562E-03 0,06262162 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 6,562E-03 0,06236286 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 6,562E-03 0,06210622 ! sister chromatid cohesion GO:0007062 9 5 0,000 6,562E-03 0,06185169 ! nerve growth factor processing GO:0032455 7 5 0,000 6,562E-03 0,06159923 ! urea metabolic process GO:0019627 6 5 0,000 6,562E-03 0,06134883 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 6,562E-03 0,06110045 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 6,562E-03 0,06085408 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 6,562E-03 0,06060968 ! neutrophil activation GO:0042119 5 5 0,000 6,562E-03 0,06036725 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 6,562E-03 0,06012674 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 6,562E-03 0,05988814 ! response to food GO:0032094 5 5 0,000 6,562E-03 0,05965143 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 6,562E-03 0,05941658 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 6,562E-03 0,05918357 ! paraxial mesoderm development GO:0048339 9 5 0,000 6,562E-03 0,05895239 ! forebrain neuron development GO:0021884 7 5 0,000 6,562E-03 0,058723 ! melanosome organization GO:0032438 7 5 0,000 6,562E-03 0,05849539 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 6,562E-03 0,05826954 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 6,562E-03 0,05804543 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 6,562E-03 0,05782303 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 6,562E-03 0,05760233 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 6,562E-03 0,05738331 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 6,562E-03 0,05716595 ! nucleoside transport GO:0015858 6 5 0,000 6,562E-03 0,05695023 ! nucleoside salvage GO:0043174 7 5 0,000 6,562E-03 0,05673613 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 6,562E-03 0,05652364 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 6,562E-03 0,05631273 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 6,562E-03 0,05610339 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 6,562E-03 0,0558956 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 6,562E-03 0,05568934 ! early endosome to late endosome transport GO:0045022 11 5 0,000 6,562E-03 0,0554846 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 6,562E-03 0,05528136 ! depyrimidination GO:0045008 8 5 0,000 6,562E-03 0,0550796 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 6,562E-03 0,05487931 ! 5S class rRNA transcription GO:0042791 8 5 0,000 6,562E-03 0,05468048 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 6,562E-03 0,05448307 ! regulation of centrosome cycle GO:0046605 7 5 0,000 6,562E-03 0,05428709 ! neuronal ion channel clustering GO:0045161 7 5 0,000 6,562E-03 0,05409251 ! sodium ion homeostasis GO:0055078 6 5 0,000 6,562E-03 0,05389933 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 6,562E-03 0,05370751 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 6,562E-03 0,05351706 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 6,562E-03 0,05332796 ! monocyte differentiation GO:0030224 8 5 0,000 6,562E-03 0,05314018 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 6,562E-03 0,05295372 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 6,562E-03 0,05276857 ! centrosome duplication GO:0051298 5 5 0,000 6,562E-03 0,05258471 ! response to UV-C GO:0010225 6 5 0,000 6,562E-03 0,05240212 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 6,562E-03 0,0522208 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 6,562E-03 0,05204073 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 6,562E-03 0,0518619 ! regulation of dendrite development GO:0050773 12 5 0,000 6,562E-03 0,05168429 ! peptidyl-arginine modification GO:0018195 7 5 0,000 6,562E-03 0,05150789 ! positive regulation of organ growth GO:0046622 6 5 0,000 6,562E-03 0,05133269 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 6,562E-03 0,05115868 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 6,562E-03 0,05098585 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 6,562E-03 0,05081418 ! regulation of dopamine secretion GO:0014059 12 5 0,000 6,562E-03 0,05064366 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 6,562E-03 0,05047429 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 6,562E-03 0,05030604 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 6,562E-03 0,05013891 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 6,562E-03 0,04997289 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 6,562E-03 0,04980796 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 6,562E-03 0,04964412 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 6,562E-03 0,04948135 ! neural tube patterning GO:0021532 6 5 0,000 6,562E-03 0,04931965 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 6,562E-03 0,04915899 ! histone demethylation GO:0016577 9 5 0,000 6,562E-03 0,04899939 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 6,562E-03 0,04884081 ! regulation of sterol transport GO:0032371 7 5 0,000 6,562E-03 0,04868326 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 6,562E-03 0,04852672 ! enteric nervous system development GO:0048484 8 5 0,000 6,562E-03 0,04837119 ! establishment of planar polarity GO:0001736 6 5 0,000 6,562E-03 0,04821665 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 6,562E-03 0,04806309 ! muscle cell proliferation GO:0033002 8 5 0,000 6,562E-03 0,04791051 ! transcription termination GO:0006353 8 5 0,000 6,562E-03 0,0477589 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 6,562E-03 0,04760824 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 6,562E-03 0,04745853 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 6,562E-03 0,04730975 ! regulation of respiratory burst GO:0060263 8 5 0,000 6,562E-03 0,04716191 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 6,562E-03 0,04701499 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 6,562E-03 0,04686898 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 6,562E-03 0,04672387 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 6,562E-03 0,04657967 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 6,562E-03 0,04643634 ! apical protein localization GO:0045176 6 5 0,000 6,562E-03 0,0462939 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 6,562E-03 0,04615233 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 6,562E-03 0,04601162 ! galactolipid metabolic process GO:0019374 7 5 0,000 6,562E-03 0,04587177 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 6,562E-03 0,04573276 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 6,562E-03 0,0455946 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 6,562E-03 0,04545726 ! triglyceride catabolic process GO:0019433 6 5 0,000 6,562E-03 0,04532076 ! glial cell migration GO:0008347 10 5 0,000 6,562E-03 0,04518506 ! determination of adult lifespan GO:0008340 8 5 0,000 6,562E-03 0,04505018 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 6,562E-03 0,04491611 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 6,562E-03 0,04478282 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 6,562E-03 0,04465033 ! somatic stem cell maintenance GO:0035019 13 5 0,000 6,562E-03 0,04451862 ! cerebellar cortex formation GO:0021697 6 5 0,000 6,562E-03 0,04438768 ! neural plate development GO:0001840 6 5 0,000 6,562E-03 0,04425751 ! regulation of sensory perception GO:0051931 6 5 0,000 6,562E-03 0,0441281 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 6,562E-03 0,04399945 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 6,562E-03 0,04387154 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 6,562E-03 0,04374438 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 6,562E-03 0,04361795 ! sensory cilium assembly GO:0035058 6 5 0,000 6,562E-03 0,04349225 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 6,562E-03 0,04336727 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 6,562E-03 0,04324301 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 6,562E-03 0,04311946 ! spindle assembly GO:0051225 5 5 0,000 6,562E-03 0,04299661 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 6,562E-03 0,04287446 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 6,562E-03 0,04275301 ! protein amino acid prenylation GO:0018346 9 5 0,000 6,562E-03 0,04263224 ! organ regeneration GO:0031100 7 5 0,000 6,562E-03 0,04251214 ! NAD biosynthetic process GO:0009435 7 5 0,000 6,562E-03 0,04239273 ! carnitine metabolic process GO:0009437 5 5 0,000 6,562E-03 0,04227398 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 6,562E-03 0,0421559 ! cellular anion homeostasis GO:0030002 6 5 0,000 6,562E-03 0,04203847 GO:0055081|anion homeostasis, ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 6,586E-03 0,04208011 ! response to oxidative stress GO:0006979 141 94 1,000 6,724E-03 0,04284164 ! regulation of response to external stimulus GO:0032101 139 96 1,000 7,004E-03 0,04449965 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 7,004E-03 0,04437706 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 7,004E-03 0,04425514 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 7,433E-03 0,04683824 ! regulation of translation GO:0006417 151 100 1,000 7,579E-03 0,04762559 ! tRNA transcription GO:0009304 11 6 0,000 7,869E-03 0,04931549 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 7,869E-03 0,04918148 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 7,869E-03 0,0490482 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 7,869E-03 0,04891564 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 7,869E-03 0,04878379 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 7,869E-03 0,04865265 ! regulation of helicase activity GO:0051095 11 6 0,000 7,869E-03 0,04852221 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 7,869E-03 0,04839248 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 7,869E-03 0,04826343 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 7,869E-03 0,04813507 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 7,869E-03 0,04800739 ! positive regulation of axon extension GO:0045773 8 6 0,000 7,869E-03 0,04788039 ! prostate gland development GO:0030850 9 6 0,000 7,869E-03 0,04775405 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 7,869E-03 0,04762838 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 7,869E-03 0,04750337 ! forebrain neuron differentiation GO:0021879 9 6 0,000 7,869E-03 0,04737902 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 7,869E-03 0,04725532 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 7,869E-03 0,04713225 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 7,869E-03 0,04700983 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 7,869E-03 0,04688805 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 7,869E-03 0,04676689 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 7,869E-03 0,04664635 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 7,869E-03 0,04652644 ! neuron adhesion GO:0007158 9 6 0,000 7,869E-03 0,04640714 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 7,869E-03 0,04628845 ! establishment of tissue polarity GO:0007164 7 6 0,000 7,869E-03 0,04617037 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 7,869E-03 0,04605289 ! signal peptide processing GO:0006465 8 6 0,000 7,869E-03 0,045936 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 7,869E-03 0,04581971 ! mRNA stabilization GO:0048255 15 6 0,000 7,869E-03 0,045704 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 7,869E-03 0,04558888 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 7,869E-03 0,04547434 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 7,869E-03 0,04536037 ! opsonization GO:0008228 8 6 0,000 7,869E-03 0,04524696 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 7,869E-03 0,04513413 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 7,869E-03 0,04502185 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 7,869E-03 0,04491014 ! protein amino acid dealkylation GO:0008214 11 6 0,000 7,869E-03 0,04479897 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 7,869E-03 0,04468836 ! regulation of odontogenesis GO:0042481 8 6 0,000 7,869E-03 0,04457829 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 7,869E-03 0,04446876 ! mechanosensory behavior GO:0007638 8 6 0,000 7,869E-03 0,04435977 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 7,869E-03 0,04425131 ! negative regulation of endocytosis GO:0045806 8 6 0,000 7,869E-03 0,04414338 ! response to interferon-gamma GO:0034341 12 6 0,000 7,869E-03 0,04403597 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 7,869E-03 0,04392909 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 7,869E-03 0,04382273 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 7,869E-03 0,04371687 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 7,869E-03 0,04361153 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 7,869E-03 0,0435067 ! cGMP-mediated signaling GO:0019934 10 6 0,000 7,869E-03 0,04340236 ! activation of MAPKKK activity GO:0000185 10 6 0,000 7,869E-03 0,04329853 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 7,869E-03 0,04319519 ! thymic T cell selection GO:0045061 12 6 0,000 7,869E-03 0,04309235 ! protein lipoylation GO:0009249 10 6 0,000 7,869E-03 0,04298999 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 7,869E-03 0,04288812 ! pigment granule organization GO:0048753 11 6 0,000 7,869E-03 0,04278673 ! drug transport GO:0015893 6 6 0,000 7,869E-03 0,04268582 ! cysteine metabolic process GO:0006534 7 6 0,000 7,869E-03 0,04258538 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 7,869E-03 0,04248541 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 7,869E-03 0,04238591 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 7,869E-03 0,04228688 ! histidine metabolic process GO:0006547 6 6 0,000 7,869E-03 0,04218831 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 7,869E-03 0,0420902 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 7,869E-03 0,04199254 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 7,869E-03 0,04189534 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 7,869E-03 0,04179858 ! adenohypophysis development GO:0021984 10 6 0,000 7,869E-03 0,04170227 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 7,869E-03 0,0416064 ! hyperosmotic response GO:0006972 8 6 0,000 7,869E-03 0,04151098 ! microtubule nucleation GO:0007020 10 6 0,000 7,869E-03 0,04141599 ! ER overload response GO:0006983 7 6 0,000 7,869E-03 0,04132143 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 7,869E-03 0,0412273 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 7,869E-03 0,0411336 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 7,869E-03 0,04104033 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 7,869E-03 0,04094748 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 7,869E-03 0,04085505 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 7,869E-03 0,04076303 ! response to dietary excess GO:0002021 7 6 0,000 7,869E-03 0,04067143 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 7,869E-03 0,04058024 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 7,869E-03 0,04048945 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 7,869E-03 0,04039908 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 7,869E-03 0,0403091 ! glycerol ether catabolic process GO:0044269 8 6 0,000 7,869E-03 0,04021952 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 7,869E-03 0,04013035 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 7,869E-03 0,04004156 ! neuron apoptosis GO:0051402 8 6 0,000 7,869E-03 0,03995317 ! organic alcohol transport GO:0015850 9 6 0,000 7,869E-03 0,03986517 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 7,869E-03 0,03977755 ! T cell mediated immunity GO:0002456 12 6 0,000 7,869E-03 0,03969032 ! male sex determination GO:0030238 9 6 0,000 7,869E-03 0,03960347 ! carnitine transport GO:0015879 8 6 0,000 7,869E-03 0,039517 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 7,869E-03 0,03943091 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 7,869E-03 0,03934519 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 7,869E-03 0,03925984 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 7,869E-03 0,03917486 ! positive regulation of exocytosis GO:0045921 6 6 0,000 7,869E-03 0,03909025 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 7,869E-03 0,039006 ! parturition GO:0007567 12 6 0,000 7,869E-03 0,03892212 ! negative regulation of translational initiation GO:0045947 7 6 0,000 7,869E-03 0,0388386 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 7,869E-03 0,03875543 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 7,869E-03 0,03867262 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 7,869E-03 0,03859016 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 7,869E-03 0,03850805 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 7,869E-03 0,0384263 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 7,869E-03 0,03834488 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 7,869E-03 0,03826382 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 7,869E-03 0,03818309 ! macrophage differentiation GO:0030225 10 6 0,000 7,869E-03 0,03810271 ! astrocyte development GO:0014002 14 6 0,000 7,869E-03 0,03802266 ! hyaluronan metabolic process GO:0030212 6 6 0,000 7,869E-03 0,03794295 ! purine base biosynthetic process GO:0009113 14 6 0,000 7,869E-03 0,03786357 ! interaction with symbiont GO:0051702 8 6 0,000 7,869E-03 0,03778452 ! anterograde axon cargo transport GO:0008089 8 6 0,000 7,869E-03 0,0377058 ! skeletal muscle contraction GO:0003009 6 6 0,000 7,869E-03 0,03762741 ! eating behavior GO:0042755 6 6 0,000 7,869E-03 0,03754935 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 7,869E-03 0,03747161 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 7,869E-03 0,03739419 ! response to copper ion GO:0046688 9 6 0,000 7,869E-03 0,03731708 ! DNA topological change GO:0006265 8 6 0,000 7,869E-03 0,0372403 ! response to exogenous dsRNA GO:0043330 8 6 0,000 7,869E-03 0,03716383 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 7,869E-03 0,03708768 ! establishment of melanosome localization GO:0032401 9 6 0,000 7,869E-03 0,03701183 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 7,869E-03 0,0369363 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 7,869E-03 0,03686107 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 7,869E-03 0,03678615 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 7,869E-03 0,03671153 ! nucleoside catabolic process GO:0009164 6 6 0,000 7,869E-03 0,03663722 ! gas homeostasis GO:0033483 11 6 0,000 7,869E-03 0,0365632 ! hair follicle maturation GO:0048820 7 6 0,000 7,869E-03 0,03648949 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 7,869E-03 0,03641607 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 7,869E-03 0,03634294 ! Schwann cell development GO:0014044 14 6 0,000 7,869E-03 0,03627011 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 7,869E-03 0,03619757 ! dendrite morphogenesis GO:0048813 9 6 0,000 7,869E-03 0,03612532 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 7,869E-03 0,03605336 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 7,869E-03 0,03598168 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 7,869E-03 0,03591029 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 7,869E-03 0,03583918 ! histone ubiquitination GO:0016574 7 6 0,000 7,869E-03 0,03576835 ! regulation of meiosis GO:0040020 10 6 0,000 7,869E-03 0,0356978 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 7,869E-03 0,03562753 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 7,869E-03 0,03555754 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 7,869E-03 0,03548782 ! regulation of mast cell activation GO:0033003 6 6 0,000 7,869E-03 0,03541837 ! membrane to membrane docking GO:0022614 12 6 0,000 7,869E-03 0,03534919 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 7,869E-03 0,03528028 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 7,869E-03 0,03521165 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 7,869E-03 0,03514327 ! receptor internalization GO:0031623 9 6 0,000 7,869E-03 0,03507517 ! neutrophil homeostasis GO:0001780 6 6 0,000 7,869E-03 0,03500732 ! coenzyme A metabolic process GO:0015936 9 6 0,000 7,869E-03 0,03493974 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 7,869E-03 0,03487242 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 7,869E-03 0,03480536 ! protein deubiquitination GO:0016579 8 6 0,000 7,869E-03 0,03473855 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 7,869E-03 0,034672 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 7,869E-03 0,03460571 ! peptidyl-histidine modification GO:0018202 9 6 0,000 7,869E-03 0,03453967 ! axonal fasciculation GO:0007413 9 6 0,000 7,869E-03 0,03447388 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 7,869E-03 0,03440834 ! thiamin metabolic process GO:0006772 6 6 0,000 7,869E-03 0,03434305 ! midbrain development GO:0030901 6 6 0,000 7,869E-03 0,034278 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 7,869E-03 0,03421321 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 7,869E-03 0,03414865 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 7,869E-03 0,03408434 ! progesterone metabolic process GO:0042448 8 6 0,000 7,869E-03 0,03402027 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 7,869E-03 0,03395645 ! glycolipid catabolic process GO:0019377 13 6 0,000 7,869E-03 0,03389286 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 7,869E-03 0,03382951 ! positive regulation of glucose import GO:0046326 6 6 0,000 7,869E-03 0,03376639 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 7,869E-03 0,03370351 ! adult feeding behavior GO:0008343 6 6 0,000 7,869E-03 0,03364087 ! blastocyst growth GO:0001832 15 6 0,000 7,869E-03 0,03357845 ! pigment granule transport GO:0051904 12 6 0,000 7,869E-03 0,03351627 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 7,869E-03 0,03345432 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 7,869E-03 0,03339259 ! catecholamine transport GO:0051937 7 6 0,000 7,869E-03 0,0333311 ! organ or tissue specific immune response GO:0002251 7 6 0,000 7,869E-03 0,03326983 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 7,869E-03 0,03320878 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 7,869E-03 0,03314796 ! negative regulation of B cell activation GO:0050869 9 6 0,000 7,869E-03 0,03308736 ! protein prenylation GO:0018342 10 6 0,000 7,869E-03 0,03302698 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 7,869E-03 0,03296682 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 7,869E-03 0,03290688 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 7,869E-03 0,03284716 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 7,869E-03 0,03278766 ! positive regulation of coagulation GO:0050820 11 6 0,000 7,869E-03 0,03272836 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 9,175E-03 0,03809021 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 9,175E-03 0,03802158 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 9,175E-03 0,03795319 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 9,175E-03 0,03788505 ! synaptonemal complex assembly GO:0007130 10 7 0,000 9,175E-03 0,03781716 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 9,175E-03 0,03774951 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 9,175E-03 0,0376821 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 9,175E-03 0,03761493 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 9,175E-03 0,037548 ! reproductive behavior GO:0019098 12 7 0,000 9,175E-03 0,0374813 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 9,175E-03 0,03741485 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 9,175E-03 0,03734863 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 9,175E-03 0,03728264 ! oligopeptide transport GO:0006857 11 7 0,000 9,175E-03 0,03721689 ! protein amino acid sulfation GO:0006477 9 7 0,000 9,175E-03 0,03715136 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 9,175E-03 0,03708607 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 9,175E-03 0,03702101 ! RNA methylation GO:0001510 11 7 0,000 9,175E-03 0,03695617 ! pericardium development GO:0060039 8 7 0,000 9,175E-03 0,03689156 ! macrophage chemotaxis GO:0048246 10 7 0,000 9,175E-03 0,03682718 ! fibril organization GO:0043206 13 7 0,000 9,175E-03 0,03676302 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 9,175E-03 0,03669909 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 9,175E-03 0,03663537 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 9,175E-03 0,03657188 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 9,175E-03 0,03650861 ! lipoprotein transport GO:0042953 9 7 0,000 9,175E-03 0,03644555 ! cerebral cortex cell migration GO:0021795 11 7 0,000 9,175E-03 0,03638271 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 9,175E-03 0,03632009 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 9,175E-03 0,03625769 ! estrogen metabolic process GO:0008210 14 7 0,000 9,175E-03 0,0361955 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 9,175E-03 0,03613352 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 9,175E-03 0,03607175 ! chemosensory behavior GO:0007635 9 7 0,000 9,175E-03 0,0360102 ! microtubule bundle formation GO:0001578 8 7 0,000 9,175E-03 0,03594885 ! T-helper 1 type immune response GO:0042088 11 7 0,000 9,175E-03 0,03588771 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 9,175E-03 0,03582678 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 9,175E-03 0,03576606 ! leukocyte degranulation GO:0043299 10 7 0,000 9,175E-03 0,03570554 ! bile acid and bile salt transport GO:0015721 9 7 0,000 9,175E-03 0,03564523 ! reflex GO:0060004 12 7 0,000 9,175E-03 0,03558512 ! positive regulation of isotype switching GO:0045830 15 7 0,000 9,175E-03 0,03552521 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 9,175E-03 0,0354655 ! protein-cofactor linkage GO:0018065 13 7 0,000 9,175E-03 0,035406 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 9,175E-03 0,03534669 ! glycerolipid catabolic process GO:0046503 9 7 0,000 9,175E-03 0,03528758 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 9,175E-03 0,03522867 ! spinal cord patterning GO:0021511 7 7 0,000 9,175E-03 0,03516996 ! hemoglobin metabolic process GO:0020027 10 7 0,000 9,175E-03 0,03511144 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 9,175E-03 0,03505311 ! adrenal gland development GO:0030325 17 7 0,000 9,175E-03 0,03499498 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 9,175E-03 0,03493704 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 9,175E-03 0,0348793 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 9,175E-03 0,03482174 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 9,175E-03 0,03476437 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 9,175E-03 0,03470719 ! endosome organization GO:0007032 10 7 0,000 9,175E-03 0,0346502 ! thyroid hormone generation GO:0006590 11 7 0,000 9,175E-03 0,0345934 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 9,175E-03 0,03453678 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 9,175E-03 0,03448035 ! regulation of pigmentation during development GO:0048070 15 7 0,000 9,175E-03 0,0344241 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 9,175E-03 0,03436804 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 9,175E-03 0,03431215 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 9,175E-03 0,03425645 ! galactose metabolic process GO:0006012 10 7 0,000 9,175E-03 0,03420093 ! vesicle fusion GO:0006906 15 7 0,000 9,175E-03 0,03414559 ! intracellular pH reduction GO:0051452 10 7 0,000 9,175E-03 0,03409043 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 9,175E-03 0,03403544 ! organ growth GO:0035265 11 7 0,000 9,175E-03 0,03398064 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 9,175E-03 0,033926 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 9,175E-03 0,03387155 ! Rac protein signal transduction GO:0016601 7 7 0,000 9,175E-03 0,03381727 ! retinol metabolic process GO:0042572 9 7 0,000 9,175E-03 0,03376316 ! behavioral fear response GO:0001662 13 7 0,000 9,175E-03 0,03370922 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 9,175E-03 0,03365546 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 9,175E-03 0,03360187 ! rRNA modification GO:0000154 12 7 0,000 9,175E-03 0,03354845 ! protein heterooligomerization GO:0051291 10 7 0,000 9,175E-03 0,0334952 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 9,175E-03 0,03344211 ! response to UV-B GO:0010224 11 7 0,000 9,175E-03 0,0333892 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 9,175E-03 0,03333645 ! protein retention in ER lumen GO:0006621 12 7 0,000 9,175E-03 0,03328387 ! intermediate filament organization GO:0045109 11 7 0,000 9,175E-03 0,03323146 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 9,175E-03 0,03317921 ! cardiac muscle cell development GO:0055013 9 7 0,000 9,175E-03 0,03312712 ! fibrinolysis GO:0042730 9 7 0,000 9,175E-03 0,0330752 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 9,175E-03 0,03302343 ! regulation of circadian rhythm GO:0042752 11 7 0,000 9,175E-03 0,03297184 ! B cell lineage commitment GO:0002326 17 7 0,000 9,175E-03 0,0329204 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 9,175E-03 0,03286912 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 9,175E-03 0,032818 ! response to tropane GO:0014073 13 7 0,000 9,175E-03 0,03276704 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 9,175E-03 0,03271624 ! melanosome localization GO:0032400 10 7 0,000 9,175E-03 0,0326656 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 9,175E-03 0,03261511 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 9,175E-03 0,03256478 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 9,175E-03 0,0325146 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 9,175E-03 0,03246458 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 9,175E-03 0,03241471 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 9,175E-03 0,03236499 ! mast cell activation GO:0045576 9 7 0,000 9,175E-03 0,03231543 ! multicellular organismal aging GO:0010259 11 7 0,000 9,175E-03 0,03226602 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 9,175E-03 0,03221675 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 9,175E-03 0,03216764 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 9,175E-03 0,03211868 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 9,175E-03 0,03206987 ! establishment of nucleus localization GO:0040023 13 7 0,000 9,175E-03 0,03202121 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 9,175E-03 0,03197269 ! T cell lineage commitment GO:0002360 12 7 0,000 9,175E-03 0,03192432 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 9,175E-03 0,03187609 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 9,175E-03 0,03182802 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 9,175E-03 0,03178008 ! regulation of lipid transport GO:0032368 13 7 0,000 9,175E-03 0,03173229 ! response to tumor cell GO:0002347 12 7 0,000 9,175E-03 0,03168465 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 9,175E-03 0,03163714 ! neuroblast proliferation GO:0007405 13 7 0,000 9,175E-03 0,03158978 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 9,175E-03 0,03154256 ! peptidyl-threonine modification GO:0018210 18 7 0,000 9,175E-03 0,03149548 ! diuresis GO:0030146 12 7 0,000 9,175E-03 0,03144855 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 9,175E-03 0,03140175 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 9,175E-03 0,03135509 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 9,175E-03 0,03130857 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 9,175E-03 0,03126218 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 9,175E-03 0,03121594 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 9,175E-03 0,03116983 ! melanin biosynthetic process GO:0042438 8 7 0,000 9,175E-03 0,03112386 ! regulation of synaptogenesis GO:0051963 10 7 0,000 9,175E-03 0,03107802 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 9,175E-03 0,03103232 ! dopamine biosynthetic process GO:0042416 15 7 0,000 9,175E-03 0,03098675 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 9,175E-03 0,03094131 ! lymph node development GO:0048535 9 7 0,000 9,175E-03 0,03089601 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 9,175E-03 0,03085084 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 9,175E-03 0,0308058 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 9,175E-03 0,0307609 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 9,175E-03 0,03071612 ! endosome to lysosome transport GO:0008333 10 7 0,000 9,175E-03 0,03067147 ! ATP catabolic process GO:0006200 10 7 0,000 9,175E-03 0,03062696 ! establishment of pigment granule localization GO:0051905 13 7 0,000 9,175E-03 0,03058257 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 9,175E-03 0,03053831 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 9,175E-03 0,03049418 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 9,175E-03 0,03045018 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 9,175E-03 0,0304063 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 9,175E-03 0,03036255 ! muscle adaptation GO:0043500 12 7 0,000 9,175E-03 0,03031893 ! amino sugar catabolic process GO:0046348 9 7 0,000 9,175E-03 0,03027543 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 9,175E-03 0,03023206 ! retina homeostasis GO:0001895 9 7 0,000 9,175E-03 0,0301888 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 9,175E-03 0,03014568 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 9,175E-03 0,03010267 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 9,175E-03 0,03005979 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 9,175E-03 0,03001703 ! behavioral response to nicotine GO:0035095 11 7 0,000 9,175E-03 0,0299744 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 9,175E-03 0,02993188 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 9,175E-03 0,02988948 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,01047886 0,03408965 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,01047886 0,0340415 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,01047886 0,03399349 ! axon extension GO:0048675 11 8 0,000 0,01047886 0,03394561 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,01047886 0,03389787 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,01047886 0,03385026 ! associative learning GO:0008306 15 8 0,000 0,01047886 0,03380278 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,01047886 0,03375544 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,01047886 0,03370823 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,01047886 0,03366115 ! phosphate transport GO:0006817 10 8 0,000 0,01047886 0,0336142 ! N-glycan processing GO:0006491 12 8 0,000 0,01047886 0,03356739 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,01047886 0,0335207 ! UTP metabolic process GO:0046051 8 8 0,000 0,01047886 0,03347414 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,01047886 0,03342771 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,01047886 0,03338142 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,01047886 0,03333525 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,01047886 0,0332892 ! succinate metabolic process GO:0006105 14 8 0,000 0,01047886 0,03324329 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,01047886 0,0331975 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,01047886 0,03315183 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,01047886 0,03310629 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,01047886 0,03306088 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,01047886 0,03301559 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,01047886 0,03297043 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,01047886 0,03292539 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,01047886 0,03288047 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01047886 0,03283567 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,01047886 0,032791 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,01047886 0,03274644 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,01047886 0,03270201 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,01047886 0,0326577 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,01047886 0,03261351 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,01047886 0,03256944 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,01047886 0,03252548 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,01047886 0,03248165 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,01047886 0,03243793 ! astrocyte differentiation GO:0048708 16 8 0,000 0,01047886 0,03239433 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,01047886 0,03235085 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,01047886 0,03230748 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,01047886 0,03226423 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,01047886 0,0322211 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,01047886 0,03217808 ! melanin metabolic process GO:0006582 12 8 0,000 0,01047886 0,03213518 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,01047886 0,03209239 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,01047886 0,03204971 ! macrophage activation GO:0042116 12 8 0,000 0,01047886 0,03200715 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,01047886 0,0319647 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,01047886 0,03192236 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,01047886 0,03188014 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,01047886 0,03183802 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01047886 0,03179602 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,01047886 0,03175413 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,01047886 0,03171235 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,01047886 0,03167067 ! ruffle organization GO:0031529 11 8 0,000 0,01047886 0,03162911 ! osteoblast development GO:0002076 13 8 0,000 0,01047886 0,03158766 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,01047886 0,03154631 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,01047886 0,03150508 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,01047886 0,03146395 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,01047886 0,03142292 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,01047886 0,03138201 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,01047886 0,0313412 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,01047886 0,0313005 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,01047886 0,0312599 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,01047886 0,03121941 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,01047886 0,03117902 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,01047886 0,03113874 ! oligodendrocyte development GO:0014003 8 8 0,000 0,01047886 0,03109856 ! segment specification GO:0007379 10 8 0,000 0,01047886 0,03105848 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,01047886 0,03101851 ! cellular extravasation GO:0045123 11 8 0,000 0,01047886 0,03097864 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,01047886 0,03093887 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,01047886 0,03089921 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,01047886 0,03085964 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,01047886 0,03082018 ! snRNA metabolic process GO:0016073 10 8 0,000 0,01047886 0,03078082 GO:0016180|snRNA processing, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 0,000 0,01047886 0,03074156 ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,01047886 0,0307024 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,01047886 0,03066334 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,01047886 0,03062437 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,01047886 0,03058551 ! nucleosome disassembly GO:0006337 12 8 0,000 0,01047886 0,03054675 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,01047886 0,03050808 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,01047886 0,03046951 ! icosanoid secretion GO:0032309 12 8 0,000 0,01047886 0,03043104 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,01047886 0,03039266 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,01047886 0,03035439 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,01047886 0,0303162 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,01047886 0,03027812 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,01047886 0,03024013 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,01047886 0,03020223 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,01047886 0,03016443 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,01047886 0,03012673 ! sterol catabolic process GO:0016127 9 8 0,000 0,01047886 0,03008912 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,01047886 0,0300516 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,01047886 0,03001417 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,01047886 0,02997684 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,01047886 0,02993961 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,01047886 0,02990246 ! prophase GO:0051324 11 8 0,000 0,01047886 0,02986541 ! S phase GO:0051320 8 8 0,000 0,01047886 0,02982844 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,01047886 0,02979157 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,01047886 0,02975479 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,01047886 0,0297181 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,01047886 0,02968151 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,01047886 0,029645 ! hormone catabolic process GO:0042447 13 8 0,000 0,01047886 0,02960858 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,01047886 0,02957225 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,01047886 0,02953601 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,01047886 0,02949986 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,01047886 0,02946379 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,01047886 0,02942782 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,01047886 0,02939193 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,01047886 0,02935613 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,01047886 0,02932042 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,01047886 0,02928479 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,01047886 0,02924925 ! lamellipodium assembly GO:0030032 9 8 0,000 0,01047886 0,0292138 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,01047886 0,02917843 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,01047886 0,02914315 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,01047886 0,02910795 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,01178131 0,03268639 ! regulation of developmental growth GO:0048638 13 9 0,000 0,01178131 0,03264701 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,01178131 0,03260772 ! telencephalon cell migration GO:0022029 16 9 0,000 0,01178131 0,03256853 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,01178131 0,03252943 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,01178131 0,03249042 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,01178131 0,03245151 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,01178131 0,0324127 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,01178131 0,03237397 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,01178131 0,03233534 ! GTP metabolic process GO:0046039 9 9 0,000 0,01178131 0,0322968 ! elastic fiber assembly GO:0048251 13 9 0,000 0,01178131 0,03225835 ! social behavior GO:0035176 14 9 0,000 0,01178131 0,03221999 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,01178131 0,03218173 ! artery development GO:0060840 19 9 0,000 0,01178131 0,03214355 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,01178131 0,03210547 ! regulation of glycolysis GO:0006110 15 9 0,000 0,01178131 0,03206747 ! response to pain GO:0048265 16 9 0,000 0,01178131 0,03202957 ! protein complex disassembly GO:0043241 17 9 0,000 0,01178131 0,03199175 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,01178131 0,03195403 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,01178131 0,03191639 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,01178131 0,03187884 ! lung alveolus development GO:0048286 17 9 0,000 0,01178131 0,03184138 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,01178131 0,03180401 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,01178131 0,03176672 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,01178131 0,03172952 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,01178131 0,03169241 ! ventral spinal cord development GO:0021517 11 9 0,000 0,01178131 0,03165539 ! protein targeting to ER GO:0045047 19 9 0,000 0,01178131 0,03161845 ! T cell selection GO:0045058 18 9 0,000 0,01178131 0,0315816 ! endoderm development GO:0007492 12 9 0,000 0,01178131 0,03154484 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,01178131 0,03150816 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,01178131 0,03147156 ! arginine catabolic process GO:0006527 10 9 0,000 0,01178131 0,03143505 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,01178131 0,03139863 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,01178131 0,03136228 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,01178131 0,03132603 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,01178131 0,03128985 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,01178131 0,03125376 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,01178131 0,03121776 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,01178131 0,03118183 ! mannose metabolic process GO:0006013 9 9 0,000 0,01178131 0,03114599 ! receptor clustering GO:0043113 15 9 0,000 0,01178131 0,03111023 ! epithelial cell development GO:0002064 10 9 0,000 0,01178131 0,03107456 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,01178131 0,03103896 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,01178131 0,03100345 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,01178131 0,03096802 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,01178131 0,03093266 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,01178131 0,03089739 ! motor axon guidance GO:0008045 14 9 0,000 0,01178131 0,0308622 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,01178131 0,03082709 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,01178131 0,03079206 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,01178131 0,03075711 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,01178131 0,03072224 ! blastoderm segmentation GO:0007350 11 9 0,000 0,01178131 0,03068745 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,01178131 0,03065273 ! DNA ligation GO:0006266 14 9 0,000 0,01178131 0,0306181 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,01178131 0,03058354 ! response to amine stimulus GO:0014075 13 9 0,000 0,01178131 0,03054906 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,01178131 0,03051466 ! erythrocyte development GO:0048821 11 9 0,000 0,01178131 0,03048033 ! renal water homeostasis GO:0003091 14 9 0,000 0,01178131 0,03044608 ! postreplication repair GO:0006301 11 9 0,000 0,01178131 0,03041191 ! mRNA cleavage GO:0006379 13 9 0,000 0,01178131 0,03037782 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,01178131 0,0303438 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,01178131 0,03030986 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,01178131 0,03027599 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,01178131 0,0302422 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,01178131 0,03020849 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,01178131 0,03017485 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,01178131 0,03014128 ! acid secretion GO:0046717 14 9 0,000 0,01178131 0,03010779 ! musculoskeletal movement GO:0050881 11 9 0,000 0,01178131 0,03007438 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,01178131 0,03004104 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,01178131 0,03000777 ! purine base metabolic process GO:0006144 18 9 0,000 0,01178131 0,02997457 ! oocyte differentiation GO:0009994 12 9 0,000 0,01178131 0,02994145 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,01178131 0,0299084 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,01178131 0,02987543 ! spleen development GO:0048536 15 9 0,000 0,01178131 0,02984253 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,01178131 0,0298097 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,01178131 0,02977694 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,01178131 0,02974425 ! detection of calcium ion GO:0005513 13 9 0,000 0,01178131 0,02971164 ! blastocyst formation GO:0001825 12 9 0,000 0,01178131 0,0296791 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,01178131 0,02964662 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,01178131 0,02961422 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,01178131 0,02958189 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,01178131 0,02954963 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,01178131 0,02951744 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,01178131 0,02948533 ! prepulse inhibition GO:0060134 14 9 0,000 0,01178131 0,02945328 ! embryonic placenta development GO:0001892 12 9 0,000 0,01178131 0,0294213 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,01178131 0,02938939 ! insulin secretion GO:0030073 17 9 0,000 0,01178131 0,02935755 ! sequestering of metal ion GO:0051238 11 9 0,000 0,01178131 0,02932577 ! response to nicotine GO:0035094 16 9 0,000 0,01178131 0,02929407 ! nucleus localization GO:0051647 15 9 0,000 0,01178131 0,02926243 ! regulation of synapse organization GO:0050807 12 9 0,000 0,01178131 0,02923087 ! localization within membrane GO:0051668 15 9 0,000 0,01178131 0,02919937 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,01308212 0,03238845 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,01308212 0,03235363 ! neuron fate specification GO:0048665 11 10 0,000 0,01308212 0,03231888 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,01308212 0,0322842 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,01308212 0,0322496 ! thyroid gland development GO:0030878 19 10 0,000 0,01308212 0,03221507 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,01308212 0,03218061 ! synapsis GO:0007129 13 10 0,000 0,01308212 0,03214623 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,01308212 0,03211193 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,01308212 0,03207769 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,01308212 0,03204353 ! sulfate transport GO:0008272 12 10 0,000 0,01308212 0,03200944 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,01308212 0,03197542 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,01308212 0,03194148 ! androgen metabolic process GO:0008209 13 10 0,000 0,01308212 0,03190761 ! phospholipid efflux GO:0033700 16 10 0,000 0,01308212 0,03187381 ! hippocampus development GO:0021766 19 10 0,000 0,01308212 0,03184008 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,01308212 0,03180642 ! blood vessel remodeling GO:0001974 21 10 0,000 0,01308212 0,03177283 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,01308212 0,03173932 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,01308212 0,03170587 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,01308212 0,0316725 GO:0010812|negative regulation of cell-substrate adhesion, ! pathogenesis GO:0009405 13 10 0,000 0,01308212 0,03163919 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,01308212 0,03160596 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,01308212 0,0315728 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,01308212 0,0315397 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,01308212 0,03150667 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,01308212 0,03147372 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,01308212 0,03144083 ! melanocyte differentiation GO:0030318 15 10 0,000 0,01308212 0,03140801 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,01308212 0,03137526 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,01308212 0,03134258 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,01308212 0,03130996 ! response to X-ray GO:0010165 16 10 0,000 0,01308212 0,03127742 ! B cell proliferation GO:0042100 14 10 0,000 0,01308212 0,03124494 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,01308212 0,03121253 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,01308212 0,03118018 ! forebrain cell migration GO:0021885 17 10 0,000 0,01308212 0,0311479 ! lipid digestion GO:0044241 15 10 0,000 0,01308212 0,03111569 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,01308212 0,03108355 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,01308212 0,03105147 ! UV protection GO:0009650 14 10 0,000 0,01308212 0,03101946 ! entry into host cell GO:0030260 20 10 0,000 0,01308212 0,03098751 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,01308212 0,03095563 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,01308212 0,03092382 ! negative regulation of ossification GO:0030279 19 10 0,000 0,01308212 0,03089207 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,01308212 0,03086038 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,01308212 0,03082876 ! regulation of bone resorption GO:0045124 24 10 0,000 0,01308212 0,03079721 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,01308212 0,03076572 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,01308212 0,03073429 ! regulation of organ growth GO:0046620 11 10 0,000 0,01308212 0,03070293 ! response to dsRNA GO:0043331 18 10 0,000 0,01308212 0,03067164 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,01308212 0,0306404 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,01308212 0,03060923 ! embryonic axis specification GO:0000578 12 10 0,000 0,01308212 0,03057812 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,01308212 0,03054708 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,01308212 0,0305161 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,01308212 0,03048518 ! cranial nerve development GO:0021545 12 10 0,000 0,01308212 0,03045433 ! fucose catabolic process GO:0019317 16 10 0,000 0,01308212 0,03042353 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,01308212 0,0303928 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,01308212 0,03036213 ! protein sumoylation GO:0016925 12 10 0,000 0,01308212 0,03033153 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,01308212 0,03030098 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,01308212 0,0302705 ! zymogen activation GO:0031638 14 10 0,000 0,01308212 0,03024007 ! salivary gland development GO:0007431 22 10 0,000 0,01308212 0,03020971 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,01308212 0,03017941 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,01308212 0,03014917 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,01308212 0,03011899 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,01308212 0,03008887 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,01308212 0,03005882 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,01308212 0,03002882 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,01308212 0,02999888 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,01308212 0,029969 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,01308212 0,02993918 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,01308212 0,02990942 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,01308212 0,02987972 ! detection of bacterium GO:0016045 10 10 0,000 0,01308212 0,02985007 ! embryonic gut development GO:0048566 11 10 0,000 0,01308212 0,02982049 ! activation of innate immune response GO:0002218 10 10 0,000 0,01308212 0,02979096 GO:0002758|innate immune response-activating signal transduction, ! cardiac cell differentiation GO:0035051 16 10 0,000 0,01308212 0,0297615 ! developmental induction GO:0031128 13 10 0,000 0,01308212 0,02973209 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,01308212 0,02970274 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,01308212 0,02967345 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,01308212 0,02964421 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,01308212 0,02961503 ! rRNA transcription GO:0009303 17 11 0,000 0,01438129 0,03252406 ! respiratory burst GO:0045730 14 11 0,000 0,01438129 0,03249211 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,01438129 0,03246022 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,01438129 0,0324284 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,01438129 0,03239664 ! virus-host interaction GO:0019048 17 11 0,000 0,01438129 0,03236494 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,01438129 0,0323333 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,01438129 0,03230173 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,01438129 0,03227021 ! RNA polyadenylation GO:0043631 19 11 0,000 0,01438129 0,03223876 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,01438129 0,03220737 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,01438129 0,03217604 ! mating GO:0007618 14 11 0,000 0,01438129 0,03214477 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,01438129 0,03211356 ! T cell proliferation GO:0042098 20 11 0,000 0,01438129 0,03208241 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,01438129 0,03205132 ! bone resorption GO:0045453 16 11 0,000 0,01438129 0,0320203 ! regulated secretory pathway GO:0045055 14 11 0,000 0,01438129 0,03198933 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,01438129 0,03195842 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,01438129 0,03192757 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,01438129 0,03189679 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,01438129 0,03186606 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,01438129 0,03183539 ! syncytium formation GO:0006949 15 11 0,000 0,01438129 0,03180478 ! plasma membrane organization GO:0007009 18 11 0,000 0,01438129 0,03177422 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,01438129 0,03174373 ! focal adhesion formation GO:0048041 24 11 0,000 0,01438129 0,0317133 ! mitotic spindle organization GO:0007052 15 11 0,000 0,01438129 0,03168292 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,01438129 0,0316526 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,01438129 0,03162234 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,01438129 0,03159214 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,01438129 0,03156199 ! adult heart development GO:0007512 11 11 0,000 0,01438129 0,0315319 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,01438129 0,03150187 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,01438129 0,0314719 ! temperature homeostasis GO:0001659 16 11 0,000 0,01438129 0,03144198 ! L-glutamate transport GO:0015813 16 11 0,000 0,01438129 0,03141212 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,01438129 0,03138232 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,01438129 0,03135258 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,01438129 0,03132289 ! stem cell development GO:0048864 29 11 0,000 0,01438129 0,03129325 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,01438129 0,03126367 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,01438129 0,03123415 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,01438129 0,03120469 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,01438129 0,03117528 ! vasoconstriction GO:0042310 15 11 0,000 0,01438129 0,03114592 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,01438129 0,03111662 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,01438129 0,03108737 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,01438129 0,03105818 ! ribosome assembly GO:0042255 13 11 0,000 0,01438129 0,03102905 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,01438129 0,03099997 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,01438129 0,03097094 ! chromatin silencing GO:0006342 19 11 0,000 0,01438129 0,03094197 ! nucleosome positioning GO:0016584 13 11 0,000 0,01438129 0,03091305 ! T cell homeostasis GO:0043029 20 11 0,000 0,01438129 0,03088419 ! regulation of isotype switching GO:0045191 19 11 0,000 0,01438129 0,03085538 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,01438129 0,03082662 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,01438129 0,03079792 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,01438129 0,03076927 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,01438129 0,03074068 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,01438129 0,03071213 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,01438129 0,03068364 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,01438129 0,03065521 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,01438129 0,03062682 ! male genitalia development GO:0030539 13 11 0,000 0,01438129 0,03059849 ! cholesterol efflux GO:0033344 19 11 0,000 0,01438129 0,03057021 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,01438129 0,03054198 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,01438129 0,03051381 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,01438129 0,03048568 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,01438129 0,03045761 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,01438129 0,03042959 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,01438129 0,03040162 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,01438129 0,03037371 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,01438129 0,03034584 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,01438129 0,03031803 ! lysogeny GO:0030069 18 11 0,000 0,01438129 0,03029026 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,01438129 0,03026255 ! acrosome reaction GO:0007340 13 11 0,000 0,01438129 0,03023489 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,01438129 0,03020728 ! lactation GO:0007595 20 12 0,000 0,01567882 0,03290264 ! reproductive cellular process GO:0048610 14 12 0,000 0,01567882 0,03287265 ! tRNA modification GO:0006400 14 12 0,000 0,01567882 0,03284271 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,01567882 0,03281283 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,01567882 0,032783 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,01567882 0,03275322 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,01567882 0,0327235 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,01567882 0,03269383 ! non-recombinational repair GO:0000726 19 12 0,000 0,01567882 0,03266422 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,01567882 0,03263466 ! peroxisomal transport GO:0043574 21 12 0,000 0,01567882 0,03260515 ! cartilage condensation GO:0001502 18 12 0,000 0,01567882 0,0325757 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,01567882 0,0325463 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,01567882 0,03251695 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,01567882 0,03248765 ! heart looping GO:0001947 15 12 0,000 0,01567882 0,03245841 ! palate development GO:0060021 15 12 0,000 0,01567882 0,03242922 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,01567882 0,03240009 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,01567882 0,032371 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,01567882 0,03234197 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,01567882 0,03231299 ! arginine metabolic process GO:0006525 13 12 0,000 0,01567882 0,03228406 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,01567882 0,03225519 ! methionine metabolic process GO:0006555 13 12 0,000 0,01567882 0,03222636 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,01567882 0,03219759 ! Golgi organization GO:0007030 18 12 0,000 0,01567882 0,03216886 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,01567882 0,03214019 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,01567882 0,03211157 ! monoamine transport GO:0015844 13 12 0,000 0,01567882 0,032083 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,01567882 0,03205449 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,01567882 0,03202602 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,01567882 0,0319976 ! L-amino acid transport GO:0015807 20 12 0,000 0,01567882 0,03196923 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,01567882 0,03194092 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,01567882 0,03191265 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,01567882 0,03188444 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,01567882 0,03185627 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,01567882 0,03182815 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,01567882 0,03180009 ! cerebellum development GO:0021549 13 12 0,000 0,01567882 0,03177207 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,01567882 0,0317441 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,01567882 0,03171618 ! histone acetylation GO:0016573 23 12 0,000 0,01567882 0,03168831 ! histone methylation GO:0016571 15 12 0,000 0,01567882 0,03166049 ! autonomic nervous system development GO:0048483 23 12 0,000 0,01567882 0,03163272 ! gland morphogenesis GO:0022612 23 12 0,000 0,01567882 0,03160499 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,01567882 0,03157732 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,01567882 0,03154969 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,01567882 0,03152211 ! response to gamma radiation GO:0010332 20 12 0,000 0,01567882 0,03149458 ! regulation of epidermis development GO:0045682 17 12 0,000 0,01567882 0,0314671 ! intestinal absorption GO:0050892 19 12 0,000 0,01567882 0,03143967 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,01567882 0,03141228 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,01567882 0,03138494 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,01567882 0,03135765 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,01567882 0,03133041 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,01567882 0,03130321 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,01567882 0,03127606 ! microspike assembly GO:0030035 23 12 0,000 0,01567882 0,03124896 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,01567882 0,0312219 ! response to cold GO:0009409 14 12 0,000 0,01567882 0,03119489 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,01697473 0,03374405 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,01697473 0,03371491 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,01697473 0,03368582 ! cGMP metabolic process GO:0046068 16 13 0,000 0,01697473 0,03365678 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,01697473 0,03362779 ! water transport GO:0006833 17 13 0,000 0,01697473 0,03359885 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,01697473 0,03356996 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,01697473 0,03354112 ! lipid localization GO:0010876 24 13 0,000 0,01697473 0,03351233 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,01697473 0,03348359 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,01697473 0,0334549 ! organelle fusion GO:0048284 28 13 0,000 0,01697473 0,03342626 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,01697473 0,03339766 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,01697473 0,03336912 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,01697473 0,03334062 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,01697473 0,03331217 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,01697473 0,03328378 ! response to hexose stimulus GO:0009746 19 13 0,000 0,01697473 0,03325542 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,01697473 0,03322712 ! glutamate metabolic process GO:0006536 18 13 0,000 0,01697473 0,03319887 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,01697473 0,03317066 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,01697473 0,0331425 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,01697473 0,03311439 ! NAD metabolic process GO:0019674 21 13 0,000 0,01697473 0,03308633 ! exocrine system development GO:0035272 27 13 0,000 0,01697473 0,03305831 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,01697473 0,03303035 ! bone mineralization GO:0030282 15 13 0,000 0,01697473 0,03300242 ! regulation of exocytosis GO:0017157 17 13 0,000 0,01697473 0,03297455 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,01697473 0,03294672 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,01697473 0,03291894 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,01697473 0,03289121 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,01697473 0,03286353 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,01697473 0,03283589 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,01697473 0,03280829 ! genitalia development GO:0048806 15 13 0,000 0,01697473 0,03278075 ! regulation of cellular pH GO:0030641 20 13 0,000 0,01697473 0,03275325 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,01697473 0,03272579 ! cellular pigmentation GO:0033059 24 13 0,000 0,01697473 0,03269838 ! tissue regeneration GO:0042246 21 13 0,000 0,01697473 0,03267102 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,01697473 0,0326437 ! cofactor transport GO:0051181 19 13 0,000 0,01697473 0,03261643 ! NADP metabolic process GO:0006739 18 13 0,000 0,01697473 0,03258921 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,01697473 0,03256203 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,01697473 0,03253489 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,01697473 0,0325078 ! gas transport GO:0015669 18 13 0,000 0,01697473 0,03248076 ! regulation of RNA stability GO:0043487 28 13 0,000 0,01697473 0,03245376 ! heme biosynthetic process GO:0006783 20 13 0,000 0,01697473 0,0324268 ! regulation of axon extension GO:0030516 23 13 0,000 0,01697473 0,03239989 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,01697473 0,03237303 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,01697473 0,0323462 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,01697473 0,03231943 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,01697473 0,0322927 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,01697473 0,03226601 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,01697473 0,03223936 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,01826899 0,03466888 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,01826899 0,0346403 ! superoxide anion generation GO:0042554 18 14 0,000 0,01826899 0,03461177 ! neuron maturation GO:0042551 21 14 0,000 0,01826899 0,03458328 ! regulation of S phase GO:0033261 18 14 0,000 0,01826899 0,03455484 ! myotube differentiation GO:0014902 21 14 0,000 0,01826899 0,03452645 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,01826899 0,0344981 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,01826899 0,0344698 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,01826899 0,03444155 ! inositol metabolic process GO:0006020 20 14 0,000 0,01826899 0,03441334 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,01826899 0,03438518 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,01826899 0,03435706 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,01826899 0,03432899 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,01826899 0,03430097 ! gene silencing by RNA GO:0031047 20 14 0,000 0,01826899 0,03427299 ! response to cAMP GO:0051591 19 14 0,000 0,01826899 0,03424506 ! limbic system development GO:0021761 25 14 0,000 0,01826899 0,03421717 ! startle response GO:0001964 21 14 0,000 0,01826899 0,03418933 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,01826899 0,03416153 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,01826899 0,03413378 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,01826899 0,03410608 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,01826899 0,03407842 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,01826899 0,0340508 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,01826899 0,03402323 ! glycine metabolic process GO:0006544 22 14 0,000 0,01826899 0,0339957 ! pituitary gland development GO:0021983 23 14 0,000 0,01826899 0,03396822 ! cellular response to starvation GO:0009267 21 14 0,000 0,01826899 0,03394078 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,01826899 0,03391339 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,01826899 0,03388604 ! regulation of heart rate GO:0002027 23 14 0,000 0,01826899 0,03385873 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,01826899 0,03383147 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,01826899 0,03380425 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,01826899 0,03377708 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,01826899 0,03374995 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,01826899 0,03372286 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,01826899 0,03369582 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,01826899 0,03366882 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,01826899 0,03364186 ! axon cargo transport GO:0008088 27 14 0,000 0,01826899 0,03361495 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,01826899 0,03358808 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,01826899 0,03356125 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,01826899 0,03353447 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,01826899 0,03350772 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,01826899 0,03348103 ! mRNA splice site selection GO:0006376 26 14 0,000 0,01826899 0,03345437 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,01826899 0,03342775 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,01826899 0,03340118 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,01826899 0,03337465 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,01826899 0,03334816 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,01826899 0,03332172 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,01826899 0,03329531 ! muscle maintenance GO:0046716 19 14 0,000 0,01826899 0,03326895 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,01826899 0,03324263 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,01826899 0,03321635 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,01826899 0,03319012 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,01826899 0,03316392 ! cell killing GO:0001906 20 14 0,000 0,01826899 0,03313777 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,01826899 0,03311165 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,01826899 0,03308558 ! cilium assembly GO:0042384 20 14 0,000 0,01826899 0,03305955 ! peptide hormone secretion GO:0030072 23 14 0,000 0,01826899 0,03303356 ! positive regulation of cell size GO:0045793 20 15 0,000 0,01956163 0,03534309 ! metencephalon development GO:0022037 19 15 0,000 0,01956163 0,03531535 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,01956163 0,03528765 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,01956163 0,03526 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,01956163 0,03523239 ! skin development GO:0043588 25 15 0,000 0,01956163 0,03520482 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,01956163 0,03517729 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,01956163 0,03514981 ! lipid phosphorylation GO:0046834 23 15 0,000 0,01956163 0,03512237 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,01956163 0,03509497 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,01956163 0,03506762 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,01956163 0,03504031 ! bile acid metabolic process GO:0008206 22 15 0,000 0,01956163 0,03501304 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,01956163 0,03498581 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,01956163 0,03495863 ! adult walking behavior GO:0007628 25 15 0,000 0,01956163 0,03493149 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,01956163 0,03490439 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,01956163 0,03487733 ! myoblast differentiation GO:0045445 27 15 0,000 0,01956163 0,03485031 ! centrosome cycle GO:0007098 16 15 0,000 0,01956163 0,03482334 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,01956163 0,03479641 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,01956163 0,03476952 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,01956163 0,03474267 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,01956163 0,03471586 ! cerebral cortex development GO:0021987 29 15 0,000 0,01956163 0,03468909 ! response to osmotic stress GO:0006970 22 15 0,000 0,01956163 0,03466237 ! vesicle coating GO:0006901 25 15 0,000 0,01956163 0,03463569 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,01956163 0,03460904 ! DNA integration GO:0015074 22 15 0,000 0,01956163 0,03458244 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,01956163 0,03455588 ! peptide secretion GO:0002790 27 15 0,000 0,01956163 0,03452936 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,01956163 0,03450288 ! regulation of vasodilation GO:0042312 24 15 0,000 0,01956163 0,03447644 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,01956163 0,03445004 ! neuron recognition GO:0008038 22 15 0,000 0,01956163 0,03442368 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,01956163 0,03439737 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,01956163 0,03437109 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,01956163 0,03434485 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,01956163 0,03431865 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,01956163 0,0342925 ! biomineral formation GO:0031214 18 15 0,000 0,01956163 0,03426638 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,01956163 0,0342403 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,01956163 0,03421426 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,01956163 0,03418826 ! dopamine metabolic process GO:0042417 30 15 0,000 0,01956163 0,03416231 ! organic cation transport GO:0015695 19 15 0,000 0,01956163 0,03413639 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,01956163 0,0341105 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,01956163 0,03408466 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,01956163 0,03405886 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,01956163 0,0340331 ! defense response to virus GO:0051607 27 15 0,000 0,01956163 0,03400737 ! peptide hormone processing GO:0016486 19 15 0,000 0,01956163 0,03398169 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,01956163 0,03395604 ! protein secretion GO:0009306 27 16 0,000 0,02085264 0,03616974 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,02085264 0,03614249 ! hormone secretion GO:0046879 25 16 0,000 0,02085264 0,03611527 ! bone remodeling GO:0046849 24 16 0,000 0,02085264 0,0360881 ! endothelial cell migration GO:0043542 22 16 0,000 0,02085264 0,03606096 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,02085264 0,03603387 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,02085264 0,03600682 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,02085264 0,03597981 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,02085264 0,03595283 ! glial cell development GO:0021782 24 16 0,000 0,02085264 0,0359259 ! patterning of blood vessels GO:0001569 24 16 0,000 0,02085264 0,03589901 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,02085264 0,03587216 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,02085264 0,03584535 ! protein polyubiquitination GO:0000209 26 16 0,000 0,02085264 0,03581858 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,02085264 0,03579185 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,02085264 0,03576516 ! fructose metabolic process GO:0006000 20 16 0,000 0,02085264 0,03573851 ! regulation of protein binding GO:0043393 27 16 0,000 0,02085264 0,0357119 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,02085264 0,03568533 ! protein export from nucleus GO:0006611 24 16 0,000 0,02085264 0,0356588 ! negative regulation of immune response GO:0050777 28 16 0,000 0,02085264 0,0356323 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,02085264 0,03560585 ! DNA replication initiation GO:0006270 25 16 0,000 0,02085264 0,03557944 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,02085264 0,03555306 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,02085264 0,03552673 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,02085264 0,03550043 ! diencephalon development GO:0021536 25 16 0,000 0,02085264 0,03547417 ! oogenesis GO:0048477 23 16 0,000 0,02085264 0,03544795 ! neural crest cell migration GO:0001755 24 16 0,000 0,02085264 0,03542177 ! G1 phase GO:0051318 27 16 0,000 0,02085264 0,03539563 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,02085264 0,03536953 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,02085264 0,03534346 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,02085264 0,03531744 ! steroid catabolic process GO:0006706 22 16 0,000 0,02085264 0,03529145 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,02085264 0,0352655 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,02085264 0,03523959 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,02085264 0,03521372 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,02085264 0,03518788 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,02085264 0,03516208 ! sperm-egg recognition GO:0035036 16 16 0,000 0,02085264 0,03513632 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,02085264 0,0351106 ! nerve development GO:0021675 18 16 0,000 0,02085264 0,03508492 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,02085264 0,03505927 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,02085264 0,03503366 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,02214203 0,03717275 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,02214203 0,03714563 ! negative regulation of defense response GO:0031348 19 17 0,000 0,02214203 0,03711856 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,02214203 0,03709153 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,02214203 0,03706453 ! glycerol metabolic process GO:0006071 20 17 0,000 0,02214203 0,03703757 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,02214203 0,03701066 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,02214203 0,03698378 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,02214203 0,03695694 ! signal complex assembly GO:0007172 29 17 0,000 0,02214203 0,03693014 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,02214203 0,03690338 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,02214203 0,03687666 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,02214203 0,03684997 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,02214203 0,03682333 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,02214203 0,03679672 ! memory GO:0007613 25 17 0,000 0,02214203 0,03677015 ! keratinization GO:0031424 17 17 0,000 0,02214203 0,03674363 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,02214203 0,03671713 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,02214203 0,03669068 ! retinoid metabolic process GO:0001523 22 17 0,000 0,02214203 0,03666427 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,02214203 0,03663789 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,02214203 0,03661155 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,02214203 0,03658525 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,02214203 0,03655898 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,02214203 0,03653276 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,02214203 0,03650657 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,02214203 0,03648042 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,02214203 0,03645431 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,02214203 0,03642823 ! heme metabolic process GO:0042168 27 17 0,000 0,02214203 0,03640219 ! actin filament bundle formation GO:0051017 26 17 0,000 0,02214203 0,03637619 ! neuromuscular junction development GO:0007528 23 17 0,000 0,02214203 0,03635022 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,02214203 0,0363243 ! body fluid secretion GO:0007589 27 17 0,000 0,02214203 0,03629841 ! stem cell differentiation GO:0048863 36 17 0,000 0,02214203 0,03627255 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,02214203 0,03624674 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,02214203 0,03622096 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,02214203 0,03619521 ! sensory perception of pain GO:0019233 23 17 0,000 0,02214203 0,03616951 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,02214203 0,03614384 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,02214203 0,0361182 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,02214203 0,0360926 ! synaptogenesis GO:0007416 24 17 0,000 0,02214203 0,03606704 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,02214203 0,03604152 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,02214203 0,03601603 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,02214203 0,03599058 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,02214203 0,03596516 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,02214203 0,03593978 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,02214203 0,03591443 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,02214203 0,03588912 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,02214203 0,03586385 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,02342979 0,03792295 ! positive regulation of translation GO:0045727 28 18 0,000 0,02342979 0,03789628 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,02342979 0,03786965 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,02342979 0,03784306 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,02342979 0,0378165 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,02342979 0,03778998 ! cAMP metabolic process GO:0046058 33 18 0,000 0,02342979 0,0377635 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,02342979 0,03773705 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,02342979 0,03771065 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,02342979 0,03768428 ! axis specification GO:0009798 26 18 0,000 0,02342979 0,03765794 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,02342979 0,03763164 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,02342979 0,03760538 ! pancreas development GO:0031016 26 18 0,000 0,02342979 0,03757916 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,02342979 0,03755297 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,02342979 0,03752682 ! glutamine metabolic process GO:0006541 23 18 0,000 0,02342979 0,03750071 ! response to retinoic acid GO:0032526 25 18 0,000 0,02342979 0,03747463 ! pigmentation during development GO:0048066 31 18 0,000 0,02342979 0,03744858 ! central nervous system neuron development GO:0021954 30 18 0,000 0,02342979 0,03742258 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,02342979 0,03739661 ! fucose metabolic process GO:0006004 26 18 0,000 0,02342979 0,03737067 ! response to fungus GO:0009620 19 18 0,000 0,02342979 0,03734478 ! peptide cross-linking GO:0018149 31 18 0,000 0,02342979 0,03731892 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,02342979 0,03729309 ! heart process GO:0003015 27 18 0,000 0,02342979 0,0372673 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,02342979 0,03724154 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,02342979 0,03721582 ! somitogenesis GO:0001756 24 18 0,000 0,02342979 0,03719014 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,02342979 0,03716449 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,02342979 0,03713888 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,02342979 0,0371133 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,02342979 0,03708776 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,02342979 0,03706225 ! vitamin transport GO:0051180 24 18 0,000 0,02342979 0,03703678 ! hormone transport GO:0009914 27 18 0,000 0,02342979 0,03701134 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,02342979 0,03698594 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,02342979 0,03696057 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,02342979 0,03693524 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,02342979 0,03690994 ! cell-cell recognition GO:0009988 20 18 0,000 0,02342979 0,03688468 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,02342979 0,03685945 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,02342979 0,03683425 ! regulation of glucose import GO:0046324 21 18 0,000 0,02342979 0,03680909 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,02342979 0,03678397 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,02342979 0,03675888 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,02342979 0,03673382 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,02342979 0,0367088 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,02471593 0,0386975 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,02471593 0,03867118 ! positive regulation of ossification GO:0045778 30 19 0,000 0,02471593 0,03864489 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,02471593 0,03861864 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,02471593 0,03859242 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,02471593 0,03856624 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,02471593 0,03854009 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,02471593 0,03851398 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,02471593 0,0384879 ! regeneration GO:0031099 32 19 0,000 0,02471593 0,03846186 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,02471593 0,03843586 ! response to alkaloid GO:0043279 32 19 0,000 0,02471593 0,03840989 ! sensory perception of taste GO:0050909 23 19 0,000 0,02471593 0,03838395 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,02471593 0,03835805 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,02471593 0,03833219 ! smooth muscle contraction GO:0006939 36 19 0,000 0,02471593 0,03830635 ! peroxisome organization GO:0007031 29 19 0,000 0,02471593 0,03828056 ! digestive system process GO:0022600 30 19 0,000 0,02471593 0,0382548 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,02471593 0,03822907 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,02471593 0,03820338 ! response to vitamin A GO:0033189 26 19 0,000 0,02471593 0,03817772 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,02471593 0,0381521 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,02471593 0,03812651 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,02471593 0,03810096 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,02471593 0,03807544 ! response to starvation GO:0042594 30 19 0,000 0,02471593 0,03804995 ! sex determination GO:0007530 29 19 0,000 0,02471593 0,0380245 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,02471593 0,03799908 ! plasma membrane fusion GO:0045026 23 19 0,000 0,02471593 0,0379737 ! cytolysis GO:0019835 20 19 0,000 0,02471593 0,03794835 ! renal system process GO:0003014 35 19 0,000 0,02471593 0,03792304 ! vasodilation GO:0042311 33 19 0,000 0,02471593 0,03789775 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,02471593 0,03787251 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,02471593 0,03784729 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,02471593 0,03782211 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,02471593 0,03779696 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,02471593 0,03777185 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,02471593 0,03774677 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,02471593 0,03772172 ! sarcomere organization GO:0045214 23 19 0,000 0,02471593 0,0376967 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,02471593 0,03767172 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,02471593 0,03764678 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,02471593 0,03762186 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,02471593 0,03759698 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,02471593 0,03757213 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,02471593 0,03754731 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,02471593 0,03752253 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,02471593 0,03749778 ! protein stabilization GO:0050821 26 19 0,000 0,02471593 0,03747306 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,02600044 0,03939461 ! iron ion transport GO:0006826 37 20 0,000 0,02600044 0,03936868 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,02600044 0,03934278 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,02600044 0,03931691 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,02600044 0,03929108 ! response to vitamin GO:0033273 29 20 0,000 0,02600044 0,03926528 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,02600044 0,03923952 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,02600044 0,03921378 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,02600044 0,03918809 ! spinal cord development GO:0021510 31 20 0,000 0,02600044 0,03916242 ! response to ethanol GO:0045471 37 20 0,000 0,02600044 0,03913679 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,02600044 0,0391112 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,02600044 0,03908564 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,02600044 0,03906011 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,02600044 0,03903461 ! chromosome condensation GO:0030261 31 20 0,000 0,02600044 0,03900915 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,02600044 0,03898372 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,02600044 0,03895832 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,02600044 0,03893296 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,02600044 0,03890763 ! pallium development GO:0021543 38 20 0,000 0,02600044 0,03888233 ! DNA modification GO:0006304 28 20 0,000 0,02600044 0,03885706 ! collagen fibril organization GO:0030199 45 20 0,000 0,02600044 0,03883183 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,02600044 0,03880663 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,02600044 0,03878147 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,02600044 0,03875633 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,02600044 0,03873123 ! collagen catabolic process GO:0030574 25 20 0,000 0,02600044 0,03870616 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,02600044 0,03868113 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,02600044 0,03865612 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,02600044 0,03863115 ! alditol metabolic process GO:0019400 24 20 0,000 0,02600044 0,03860621 ! actin filament-based movement GO:0030048 34 20 0,000 0,02600044 0,0385813 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,02728334 0,04045886 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,02728334 0,04043279 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,02728334 0,04040675 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,02728334 0,04038075 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,02728334 0,04035478 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,02728334 0,04032885 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,02728334 0,04030295 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,02728334 0,04027708 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,02728334 0,04025124 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,02728334 0,04022544 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,02728334 0,04019967 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,02728334 0,04017394 ! protein amino acid acylation GO:0043543 37 21 0,000 0,02728334 0,04014823 ! vesicle docking GO:0048278 27 21 0,000 0,02728334 0,04012256 ! phototransduction GO:0007602 25 21 0,000 0,02728334 0,04009693 ! dendrite development GO:0016358 35 21 0,000 0,02728334 0,04007132 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,02728334 0,04004575 ! ovarian follicle development GO:0001541 30 21 0,000 0,02728334 0,04002021 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,02728334 0,0399947 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,02728334 0,03996923 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,02728334 0,03994379 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,02728334 0,03991838 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,02728334 0,039893 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,02728334 0,03986766 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,02728334 0,03984234 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,02728334 0,03981706 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,02728334 0,03979181 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,02728334 0,0397666 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,02728334 0,03974141 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,02728334 0,03971626 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,02728334 0,03969114 ! fatty acid transport GO:0015908 30 21 0,000 0,02728334 0,03966605 ! immunoglobulin production GO:0002377 33 21 0,000 0,02728334 0,03964099 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,02728334 0,03961597 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,02728334 0,03959097 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,02728334 0,03956601 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,02728334 0,03954108 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,02728334 0,03951618 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,02728334 0,03949131 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,02728334 0,03946647 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,02728334 0,03944167 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,02728334 0,03941689 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,02728334 0,03939215 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,02728334 0,03936743 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,02728334 0,03934275 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,02728334 0,0393181 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,02728334 0,03929348 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,02856463 0,04111304 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,02856463 0,04108733 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,02856463 0,04106165 ! viral genome replication GO:0019079 29 22 0,000 0,02856463 0,041036 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,02856463 0,04101039 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,02856463 0,0409848 ! leukocyte adhesion GO:0007159 38 22 0,000 0,02856463 0,04095925 ! molting cycle process GO:0022404 40 22 0,000 0,02856463 0,04093373 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,02856463 0,04090824 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,02856463 0,04088279 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,02856463 0,04085736 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,02856463 0,04083197 ! vasculogenesis GO:0001570 33 22 0,000 0,02856463 0,04080661 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,02856463 0,04078128 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,02856463 0,04075598 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,02856463 0,04073071 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,02856463 0,04070548 ! lysosome organization GO:0007040 37 22 0,000 0,02856463 0,04068027 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,02856463 0,0406551 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,02856463 0,04062996 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,02856463 0,04060485 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,02856463 0,04057977 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,02856463 0,04055472 ! membrane depolarization GO:0051899 35 22 0,000 0,02856463 0,0405297 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,02856463 0,04050471 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,02856463 0,04047975 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,02856463 0,04045483 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,02856463 0,04042993 ! blastocyst development GO:0001824 37 22 0,000 0,02856463 0,04040507 ! neural tube closure GO:0001843 33 22 0,000 0,02856463 0,04038023 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,02856463 0,04035543 ! protein tetramerization GO:0051262 39 22 0,000 0,02856463 0,04033066 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,0298443 0,04211158 ! neuron fate commitment GO:0048663 32 23 0,000 0,0298443 0,04208576 ! embryonic pattern specification GO:0009880 31 23 0,000 0,0298443 0,04205997 ! myelination GO:0042552 35 23 0,000 0,0298443 0,04203422 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,0298443 0,04200849 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,0298443 0,0419828 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,0298443 0,04195714 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,0298443 0,04193151 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,0298443 0,04190591 ! vesicle targeting GO:0006903 32 23 0,000 0,0298443 0,04188034 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,0298443 0,0418548 ! osteoblast differentiation GO:0001649 40 23 0,000 0,0298443 0,0418293 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,0298443 0,04180382 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,0298443 0,04177838 ! interaction with host GO:0051701 37 23 0,000 0,0298443 0,04175297 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,0298443 0,04172759 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,0298443 0,04170224 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,0298443 0,04167692 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,0298443 0,04165163 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,0298443 0,04162637 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,0298443 0,04160114 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,0298443 0,04157594 ! cell fate determination GO:0001709 45 23 0,000 0,0298443 0,04155077 ! pentose metabolic process GO:0019321 31 23 0,000 0,0298443 0,04152564 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,0298443 0,04150053 ! spermatid development GO:0007286 33 23 0,000 0,0298443 0,04147546 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,0298443 0,04145041 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,0298443 0,04142539 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,0298443 0,04140041 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,0298443 0,04137545 ! telomere organization GO:0032200 32 23 0,000 0,0298443 0,04135053 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,0298443 0,04132563 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,0298443 0,04130077 ! regulation of amine transport GO:0051952 38 23 0,000 0,0298443 0,04127593 ! liver development GO:0001889 40 23 0,000 0,0298443 0,04125113 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,03112235 0,04299184 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,03112235 0,04296603 ! initiation of viral infection GO:0019059 42 24 0,000 0,03112235 0,04294026 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,03112235 0,04291451 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,03112235 0,0428888 ! superoxide metabolic process GO:0006801 32 24 0,000 0,03112235 0,04286312 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,03112235 0,04283747 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,03112235 0,04281185 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,03112235 0,04278626 ! sperm motility GO:0030317 27 24 0,000 0,03112235 0,0427607 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,03112235 0,04273517 ! vacuole organization GO:0007033 39 24 0,000 0,03112235 0,04270967 ! receptor metabolic process GO:0043112 37 24 0,000 0,03112235 0,0426842 ! neural crest cell development GO:0014032 39 24 0,000 0,03112235 0,04265877 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,03112235 0,04263336 ! primary neural tube formation GO:0014020 35 24 0,000 0,03112235 0,04260798 ! negative regulation of cell development GO:0010721 56 24 0,000 0,03112235 0,04258263 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,03112235 0,04255732 ! base-excision repair GO:0006284 31 24 0,000 0,03112235 0,04253203 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,03112235 0,04250677 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,03112235 0,04248155 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,03112235 0,04245635 ! glutathione metabolic process GO:0006749 29 24 0,000 0,03112235 0,04243118 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,03112235 0,04240605 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,03112235 0,04238094 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,03112235 0,04235586 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,0323988 0,04406696 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,0323988 0,04404092 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,0323988 0,0440149 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,0323988 0,04398892 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,0323988 0,04396297 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,0323988 0,04393705 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,0323988 0,04391116 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,0323988 0,0438853 ! peptide transport GO:0015833 43 25 0,000 0,0323988 0,04385947 ! male gonad development GO:0008584 33 25 0,000 0,0323988 0,04383367 ! iron ion homeostasis GO:0055072 39 25 0,000 0,0323988 0,0438079 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,0323988 0,04378216 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,0323988 0,04375645 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,0323988 0,04373077 ! phospholipid transport GO:0015914 35 25 0,000 0,0323988 0,04370512 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,0323988 0,0436795 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,0323988 0,04365391 ! detection of light stimulus GO:0009583 30 25 0,000 0,0323988 0,04362836 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,0323988 0,04360283 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,0323988 0,04357733 ! leukocyte proliferation GO:0070661 39 25 0,000 0,0323988 0,04355186 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,0323988 0,04352642 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,03367363 0,0452127 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,03367363 0,04518632 ! translational initiation GO:0006413 43 26 0,000 0,03367363 0,04515998 ! regulation of pH GO:0006885 36 26 0,000 0,03367363 0,04513366 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,03367363 0,04510737 ! circadian rhythm GO:0007623 42 26 0,000 0,03367363 0,04508112 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,03367363 0,04505489 ! post-embryonic development GO:0009791 42 26 0,000 0,03367363 0,0450287 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,03367363 0,04500253 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,03367363 0,0449764 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,03367363 0,04495029 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,03367363 0,04492422 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,03367363 0,04489818 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,03367363 0,04487217 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,03367363 0,04484618 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,03494686 0,04651492 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,03494686 0,04648802 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,03494686 0,04646115 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,03494686 0,04643431 ! membrane docking GO:0022406 39 27 0,000 0,03494686 0,0464075 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,03494686 0,04638072 ! catechol metabolic process GO:0009712 43 27 0,000 0,03494686 0,04635397 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,03494686 0,04632725 ! acute-phase response GO:0006953 42 27 0,000 0,03494686 0,04630057 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,03494686 0,04627391 ! myofibril assembly GO:0030239 36 27 0,000 0,03494686 0,04624729 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,03494686 0,04622069 ! response to ionizing radiation GO:0010212 47 27 0,000 0,03494686 0,04619413 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,03494686 0,0461676 ! natural killer cell activation GO:0030101 35 27 0,000 0,03494686 0,04614109 ! lipid oxidation GO:0034440 38 27 0,000 0,03494686 0,04611462 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,03494686 0,04608818 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,03494686 0,04606177 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,03494686 0,04603539 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,03494686 0,04600904 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,03494686 0,04598272 ! gene silencing GO:0016458 41 27 0,000 0,03494686 0,04595642 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,03621849 0,04760144 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,03621849 0,04757426 ! phenol metabolic process GO:0018958 44 28 0,000 0,03621849 0,0475471 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,03621849 0,04751998 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,03621849 0,04749289 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,03621849 0,04746583 ! cell junction assembly GO:0034329 56 28 0,000 0,03621849 0,0474388 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,03621849 0,0474118 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,03621849 0,04738483 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,03621849 0,04735789 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,03621849 0,04733098 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,03621849 0,0473041 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,03621849 0,04727726 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,03621849 0,04725044 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,03621849 0,04722365 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,03621849 0,0471969 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,03621849 0,04717017 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,03621849 0,04714348 ! mesoderm formation GO:0001707 46 28 0,000 0,03621849 0,04711681 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,03621849 0,04709018 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,03621849 0,04706357 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,03621849 0,047037 ! ensheathment of neurons GO:0007272 43 28 0,000 0,03621849 0,04701045 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,03621849 0,04698394 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,03621849 0,04695746 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,03621849 0,046931 ! neural tube formation GO:0001841 41 28 0,000 0,03621849 0,04690458 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,03621849 0,04687818 ! placenta development GO:0001890 37 28 0,000 0,03621849 0,04685181 ! regulation of B cell activation GO:0050864 42 28 0,000 0,03621849 0,04682548 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,03748851 0,04844021 ! regulation of innate immune response GO:0045088 38 29 0,000 0,03748851 0,04841301 ! ovulation cycle process GO:0022602 41 29 0,000 0,03748851 0,04838585 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,03748851 0,04835871 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,03748851 0,0483316 ! mismatch repair GO:0006298 34 29 0,000 0,03748851 0,04830453 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,03748851 0,04827748 ! muscle cell development GO:0055001 38 29 0,000 0,03748851 0,04825046 ! formation of primary germ layer GO:0001704 48 29 0,000 0,03748851 0,04822348 ! telencephalon development GO:0021537 52 29 0,000 0,03748851 0,04819652 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,03748851 0,0481696 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,03748851 0,0481427 ! tissue homeostasis GO:0001894 42 29 0,000 0,03748851 0,04811584 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,03875693 0,04971609 ! collagen metabolic process GO:0032963 40 30 0,000 0,03875693 0,04968838 ! organic anion transport GO:0015711 51 30 0,000 0,03875693 0,0496607 ! cholesterol transport GO:0030301 46 30 0,000 0,03875693 0,04963304 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,03875693 0,04960542 ! spliceosome assembly GO:0000245 49 30 0,000 0,03875693 0,04957784 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,03875693 0,04955028 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,03875693 0,04952275 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,03875693 0,04949525 ! ceramide metabolic process GO:0006672 43 30 0,000 0,03875693 0,04946778 ! ovulation cycle GO:0042698 43 30 0,000 0,03875693 0,04944035 ! hindbrain development GO:0030902 45 30 0,000 0,03875693 0,04941294 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,03875693 0,04938557 ! adult locomotory behavior GO:0008344 47 30 0,000 0,03875693 0,04935822 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,03875693 0,04933091 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,03875693 0,04930362 ! response to heat GO:0009408 41 30 0,000 0,03875693 0,04927637 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,03875693 0,04924914 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,03875693 0,04922195 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,04002376 0,05080278 ! negative regulation of secretion GO:0051048 49 31 0,000 0,04002376 0,05077476 ! mammary gland development GO:0030879 57 31 0,000 0,04002376 0,05074677 ! glial cell differentiation GO:0010001 55 31 0,000 0,04002376 0,05071881 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,04002376 0,05069088 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,04002376 0,05066298 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,04002376 0,05063512 ! odontogenesis GO:0042476 50 31 0,000 0,04002376 0,05060728 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,04002376 0,05057947 ! segmentation GO:0035282 41 31 0,000 0,04002376 0,0505517 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,04002376 0,05052395 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,04002376 0,05049624 ! metanephros development GO:0001656 58 31 0,000 0,04002376 0,05046855 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,04002376 0,0504409 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,04002376 0,05041327 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,04002376 0,05038568 ! cell fate specification GO:0001708 37 31 0,000 0,04002376 0,05035812 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,04002376 0,05033058 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,04002376 0,05030308 ! RNA modification GO:0009451 40 31 0,000 0,04002376 0,05027561 ! regulation of muscle development GO:0048634 48 32 0,000 0,04128898 0,0518366 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,04128898 0,05180832 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,04128898 0,05178008 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,04128898 0,05175186 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,04128898 0,05172367 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,04128898 0,05169551 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,04128898 0,05166739 ! peripheral nervous system development GO:0007422 53 32 0,000 0,04128898 0,05163929 ! regulation of protein stability GO:0031647 48 32 0,000 0,04128898 0,05161123 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,04128898 0,05158319 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,04128898 0,05155519 ! cytokine production GO:0001816 44 32 0,000 0,04128898 0,05152722 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,04128898 0,05149927 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,04128898 0,05147136 ! vesicle localization GO:0051648 47 32 0,000 0,04128898 0,05144348 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,04255261 0,05298918 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,04255261 0,0529605 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,04255261 0,05293186 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,04255261 0,05290325 ! sister chromatid segregation GO:0000819 46 33 0,000 0,04255261 0,05287467 ! ear morphogenesis GO:0042471 42 33 0,000 0,04255261 0,05284612 ! actomyosin structure organization GO:0031032 43 33 0,000 0,04255261 0,0528176 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,04255261 0,05278911 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,04255261 0,05276065 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,04255261 0,05273222 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,04255261 0,05270383 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,04255261 0,05267546 ! female gonad development GO:0008585 49 33 0,000 0,04255261 0,05264713 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,04255261 0,05261882 ! positive regulation of cell development GO:0010720 54 33 0,000 0,04255261 0,05259055 ! lipid homeostasis GO:0055088 55 33 0,000 0,04255261 0,0525623 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,04255261 0,05253409 ! regulation of proteolysis GO:0030162 50 33 0,000 0,04255261 0,05250591 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,04255261 0,05247775 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,04255261 0,05244963 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,04255261 0,05242154 ! cytokinesis GO:0000910 52 33 0,000 0,04255261 0,05239347 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,04255261 0,05236544 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,04381465 0,05388968 ! mRNA catabolic process GO:0006402 48 34 0,000 0,04381465 0,05386087 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,04381465 0,0538321 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,04381465 0,05380336 ! feeding behavior GO:0007631 45 34 0,000 0,04381465 0,05377465 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,04381465 0,05374597 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,04381465 0,05371732 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,04381465 0,0536887 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,04381465 0,05366011 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,04381465 0,05363156 ! neuron migration GO:0001764 46 34 0,000 0,04381465 0,05360303 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,04381465 0,05357453 ! female gamete generation GO:0007292 43 34 0,000 0,04381465 0,05354607 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,04381465 0,05351763 ! polyol metabolic process GO:0019751 44 34 0,000 0,04381465 0,05348922 ! aerobic respiration GO:0009060 47 34 0,000 0,04381465 0,05346085 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,04381465 0,0534325 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,04381465 0,05340418 ! embryonic organ development GO:0048568 45 34 0,000 0,04381465 0,0533759 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,04381465 0,05334764 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,0450751 0,05485329 ! Notch signaling pathway GO:0007219 56 35 0,000 0,0450751 0,05482428 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,0450751 0,05479531 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,0450751 0,05476636 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,0450751 0,05473745 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,0450751 0,05470856 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,0450751 0,05467971 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,0450751 0,05465088 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,0450751 0,05462209 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,0450751 0,05459332 ! glycogen metabolic process GO:0005977 48 35 0,000 0,0450751 0,05456459 ! pigment metabolic process GO:0042440 61 35 0,000 0,0450751 0,05453589 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,0450751 0,05450721 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,0450751 0,05447857 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,04633395 0,05597064 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,04633395 0,05594126 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,04633395 0,05591191 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,04633395 0,05588259 ! negative regulation of binding GO:0051100 58 36 0,000 0,04633395 0,0558533 ! organic ether metabolic process GO:0018904 46 36 0,000 0,04633395 0,05582404 ! tissue remodeling GO:0048771 62 36 0,000 0,04633395 0,05579481 ! neural tube development GO:0021915 50 36 0,000 0,04633395 0,05576562 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,04633395 0,05573645 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,04633395 0,05570731 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,04633395 0,05567821 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,04633395 0,05564913 ! glucan metabolic process GO:0044042 49 36 0,000 0,04633395 0,05562009 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,04759122 0,05709954 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,04759122 0,05706977 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,04759122 0,05704003 ! ion transmembrane transport GO:0034220 56 37 0,000 0,04759122 0,05701032 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,04759122 0,05698064 ! regulation of protein secretion GO:0050708 51 37 0,000 0,04759122 0,05695099 ! amino acid activation GO:0043038 52 37 0,000 0,04759122 0,05692138 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,04759122 0,05689179 ! gliogenesis GO:0042063 71 38 0,000 0,04884691 0,05836254 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,04884691 0,05833223 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,04884691 0,05830196 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,04884691 0,05827172 ! phagocytosis GO:0006909 60 38 0,000 0,04884691 0,05824152 ! mesenchymal cell development GO:0014031 64 38 0,000 0,04884691 0,05821134 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,04884691 0,05818119 ! maintenance of location in cell GO:0051651 69 38 0,000 0,04884691 0,05815108 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,05010101 0,0596132 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,05010101 0,05958238 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,05010101 0,05955158 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,05010101 0,05952082 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,05010101 0,05949009 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,05010101 0,0594594 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,05010101 0,05942873 ! male sex differentiation GO:0046661 53 39 0,000 0,05010101 0,0593981 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,05010101 0,0593675 ! chromatin remodeling GO:0006338 68 39 0,000 0,05010101 0,05933693 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,05010101 0,05930639 ! JNK cascade GO:0007254 54 39 0,000 0,05010101 0,05927588 ! developmental growth GO:0048589 62 39 0,000 0,05010101 0,05924541 ! synapse organization GO:0050808 55 39 0,000 0,05010101 0,05921496 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,05135352 0,06066415 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,05135352 0,06063301 ! regulation of tube size GO:0035150 60 40 0,000 0,05135352 0,0606019 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,05135352 0,06057082 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,05135352 0,06053978 ! peptide metabolic process GO:0006518 56 40 0,000 0,05135352 0,06050876 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,05135352 0,06047778 ! inner ear development GO:0048839 57 40 0,000 0,05135352 0,06044683 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,05135352 0,06041591 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,05135352 0,06038502 ! double-strand break repair GO:0006302 67 40 0,000 0,05135352 0,06035417 ! B cell differentiation GO:0030183 62 40 0,000 0,05135352 0,06032334 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,05135352 0,06029255 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,05135352 0,06026179 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,05135352 0,06023106 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,05260446 0,0616668 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,05260446 0,06163539 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,05260446 0,061604 ! glucose transport GO:0015758 52 41 0,000 0,05260446 0,06157265 ! endosome transport GO:0016197 71 41 0,000 0,05260446 0,06154133 ! striated muscle contraction GO:0006941 62 41 0,000 0,05260446 0,06151005 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,05260446 0,06147879 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,05260446 0,06144757 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,05260446 0,06141638 ! biopolymer methylation GO:0043414 62 41 0,000 0,05260446 0,06138522 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,05260446 0,06135409 ! mitochondrial transport GO:0006839 60 42 0,000 0,05385382 0,06277942 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,05385382 0,06274762 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,05385382 0,06271584 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,05385382 0,06268411 ! cellular component disassembly GO:0022411 64 42 0,000 0,05385382 0,0626524 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,05385382 0,06262072 ! hexose transport GO:0008645 54 42 0,000 0,05385382 0,06258908 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,05385382 0,06255747 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,05385382 0,06252589 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,05385382 0,06249435 ! excretion GO:0007588 63 42 0,000 0,05385382 0,06246283 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,05385382 0,06243135 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,05385382 0,0623999 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,05385382 0,06236848 ! regulation of cell shape GO:0008360 78 42 0,000 0,05385382 0,06233709 ! positive regulation of binding GO:0051099 59 43 0,000 0,05510161 0,06374934 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,05510161 0,06371729 ! leukocyte migration GO:0050900 60 43 0,000 0,05510161 0,06368528 ! neuromuscular process GO:0050905 79 43 0,000 0,05510161 0,06365329 ! activation of caspase activity GO:0006919 65 43 0,000 0,05510161 0,06362133 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,05510161 0,06358941 ! tRNA processing GO:0008033 49 43 0,000 0,05510161 0,06355752 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,05510161 0,06352566 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,05510161 0,06349384 ! methylation GO:0032259 64 43 0,000 0,05510161 0,06346204 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,05634782 0,06486486 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,05634782 0,06483241 ! regulation of action potential GO:0001508 71 44 0,000 0,05634782 0,06479999 ! regulation of ion transport GO:0043269 57 44 0,000 0,05634782 0,06476761 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,05634782 0,06473526 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,05634782 0,06470294 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,05634782 0,06467065 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,05634782 0,06463839 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,05634782 0,06460617 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,05634782 0,06457398 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,05634782 0,06454182 ! RNA catabolic process GO:0006401 64 45 0,000 0,05759246 0,06593462 ! positive regulation of defense response GO:0031349 59 45 0,000 0,05759246 0,06590182 ! regulation of translational initiation GO:0006446 64 45 0,000 0,05759246 0,06586904 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,05759246 0,06583631 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,05759246 0,0658036 ! cell recognition GO:0008037 58 45 0,000 0,05759246 0,06577093 ! cell maturation GO:0048469 60 45 0,000 0,05759246 0,06573829 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,05759246 0,06570568 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,05883552 0,06709058 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,05883552 0,06705734 ! cell redox homeostasis GO:0045454 63 46 0,000 0,05883552 0,06702412 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,05883552 0,06699094 ! regulation of ossification GO:0030278 71 46 0,000 0,05883552 0,0669578 ! histone modification GO:0016570 68 46 0,000 0,05883552 0,06692468 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,05883552 0,0668916 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,06007702 0,06826934 ! viral infectious cycle GO:0019058 71 47 0,000 0,06007702 0,06823563 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,06007702 0,06820195 ! endocrine system development GO:0035270 83 47 0,000 0,06007702 0,0681683 ! covalent chromatin modification GO:0016569 75 47 0,000 0,06007702 0,06813469 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,06007702 0,06810111 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,06007702 0,06806756 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,06007702 0,06803405 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,06007702 0,06800057 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,06007702 0,06796712 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of protein polymerization GO:0032271 71 47 0,000 0,06007702 0,0679337 ! chloride transport GO:0006821 67 48 0,000 0,06131696 0,06930172 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,06131696 0,06926768 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,06131696 0,06923368 ! response to temperature stimulus GO:0009266 62 48 0,000 0,06131696 0,06919971 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,06131696 0,06916577 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,06131696 0,06913186 ! gastrulation GO:0007369 73 48 0,000 0,06131696 0,06909799 ! heart morphogenesis GO:0003007 65 48 0,000 0,06131696 0,06906415 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,06131696 0,06903035 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,06131696 0,06899658 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,06131696 0,06896284 ! regulation of endocytosis GO:0030100 63 48 0,000 0,06131696 0,06892913 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,06131696 0,06889546 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,06131696 0,06886182 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,06255532 0,07021828 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,06255532 0,07018402 ! sensory perception of smell GO:0007608 61 49 0,000 0,06255532 0,0701498 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,06255532 0,07011562 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,06255532 0,07008146 ! RNA elongation GO:0006354 62 49 0,000 0,06255532 0,07004734 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,06255532 0,07001326 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,06255532 0,06997921 ! germ cell development GO:0007281 68 49 0,000 0,06255532 0,06994519 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,06255532 0,0699112 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,06255532 0,06987724 ! cartilage development GO:0051216 70 49 0,000 0,06255532 0,06984332 ! maintenance of location GO:0051235 84 49 0,000 0,06255532 0,06980944 ! regulation of actin filament length GO:0030832 72 50 0,000 0,06379213 0,07115514 ! ear development GO:0043583 72 50 0,000 0,06379213 0,07112065 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,06379213 0,07108619 ! membrane fusion GO:0006944 80 50 0,000 0,06379213 0,07105177 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,06379213 0,07101738 ! lipid modification GO:0030258 73 50 0,000 0,06379213 0,07098302 ! positive regulation of growth GO:0045927 67 50 0,000 0,06379213 0,07094869 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,06379213 0,0709144 ! proton transport GO:0015992 75 50 0,000 0,06379213 0,07088014 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,06379213 0,07084592 ! positive regulation of secretion GO:0051047 71 51 0,000 0,06502737 0,0721829 ! hydrogen transport GO:0006818 77 51 0,000 0,06502737 0,07214808 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,06502737 0,07211329 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,06502737 0,07207854 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,06502737 0,07204382 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,06502737 0,07200913 ! adult behavior GO:0030534 80 51 0,000 0,06502737 0,07197448 ! transition metal ion transport GO:0000041 74 52 0,000 0,06626106 0,07330468 ! regulation of cellular component size GO:0032535 74 52 0,000 0,06626106 0,07326944 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,06626106 0,07323423 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,06626106 0,07319906 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,06626106 0,07316392 ! establishment of organelle localization GO:0051656 85 52 0,000 0,06626106 0,07312881 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,06749319 0,07445292 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,06749319 0,07441723 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,06749319 0,07438157 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,06749319 0,07434594 ! kidney development GO:0001822 90 53 0,000 0,06749319 0,07431036 ! single fertilization GO:0007338 59 53 0,000 0,06749319 0,0742748 ! amino acid transport GO:0006865 84 54 0,000 0,06872376 0,07559285 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,06872376 0,07555672 ! regulation of mitosis GO:0007088 84 54 0,000 0,06872376 0,07552062 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,06872376 0,07548455 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,06872376 0,07544852 ! DNA catabolic process GO:0006308 67 54 0,000 0,06872376 0,07541252 ! detection of external stimulus GO:0009581 66 54 0,000 0,06872376 0,07537656 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,06872376 0,07534063 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,06872376 0,07530474 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,06872376 0,07526888 ! exocytosis GO:0006887 74 55 0,000 0,06995278 0,07657848 ! mesoderm development GO:0007498 76 55 0,000 0,06995278 0,07654205 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,06995278 0,07650566 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,06995278 0,07646929 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,07118025 0,07777414 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,07118025 0,07773721 ! negative regulation of protein kinase activity GO:0006469 99 57 0,000 0,07240617 0,07903853 ! carbohydrate transport GO:0008643 74 57 0,000 0,07240617 0,07900104 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,07240617 0,07896358 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,07240617 0,07892615 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,07240617 0,07888877 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,07240617 0,07885141 ! camera-type eye development GO:0043010 88 57 0,000 0,07240617 0,0788141 ! secondary metabolic process GO:0019748 84 57 0,000 0,07240617 0,07877681 ! developmental maturation GO:0021700 75 57 0,000 0,07240617 0,07873957 ! gonad development GO:0008406 79 57 0,000 0,07240617 0,07870236 ! negative regulation of kinase activity GO:0033673 100 58 0,000 0,07363054 0,07999539 ! viral reproductive process GO:0022415 87 58 0,000 0,07363054 0,07995762 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,07363054 0,07991988 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,07363054 0,07988219 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,07363054 0,07984452 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,07485336 0,0811323 ! activation of MAPK activity GO:0000187 84 59 0,000 0,07485336 0,08109408 ! lung development GO:0030324 94 59 0,000 0,07485336 0,0810559 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,07485336 0,08101776 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,07485336 0,08097965 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,07607464 0,08226219 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,07607464 0,08222353 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,07607464 0,08218491 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,07607464 0,08214633 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,07607464 0,08210778 ! regulation of heart contraction GO:0008016 91 60 0,000 0,07607464 0,08206927 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,07607464 0,08203079 ! fertilization GO:0009566 68 60 0,000 0,07607464 0,08199235 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,07607464 0,08195395 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,07729438 0,08322897 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,07729438 0,08319002 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,07729438 0,08315111 ! urogenital system development GO:0001655 101 61 0,000 0,07729438 0,08311224 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,07729438 0,0830734 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,07729438 0,0830346 ! extracellular matrix organization GO:0030198 103 61 0,000 0,07729438 0,08299583 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,07729438 0,08295711 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 0,000 0,07729438 0,08291841 ! amine catabolic process GO:0009310 90 62 0,000 0,07851258 0,08418598 ! neurotransmitter transport GO:0006836 81 62 0,000 0,07851258 0,08414675 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,07851258 0,08410756 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,07851258 0,0840684 ! respiratory tube development GO:0030323 99 62 0,000 0,07851258 0,08402928 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,07851258 0,0839902 ! organelle localization GO:0051640 96 62 0,000 0,07851258 0,08395115 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,07972924 0,08521248 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,07972924 0,0851729 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,07972924 0,08513336 ! viral reproduction GO:0016032 92 63 0,000 0,07972924 0,08509385 ! regulation of lipase activity GO:0060191 109 63 0,000 0,07972924 0,08505438 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,08094436 0,08631063 ! negative regulation of cell size GO:0045792 108 64 0,000 0,08094436 0,08627064 ! appendage morphogenesis GO:0035107 93 64 0,000 0,08094436 0,08623068 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,08094436 0,08619076 ! respiratory system development GO:0060541 100 64 0,000 0,08094436 0,08615087 ! adaptive immune response GO:0002250 94 64 0,000 0,08094436 0,08611102 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,08215795 0,08736167 ! regulation of caspase activity GO:0043281 97 65 0,000 0,08215795 0,0873213 ! appendage development GO:0048736 94 65 0,000 0,08215795 0,08728096 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,08215795 0,08724067 ! defense response to bacterium GO:0042742 73 65 0,000 0,08215795 0,08720041 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,08215795 0,08716019 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,08215795 0,08712 ! activation of immune response GO:0002253 83 65 0,000 0,08215795 0,08707986 ! protein oligomerization GO:0051259 100 65 0,000 0,08215795 0,08703974 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,08337001 0,08828316 ! antigen processing and presentation GO:0019882 96 66 0,000 0,08337001 0,08824253 ! axon guidance GO:0007411 99 66 0,000 0,08337001 0,08820194 ! regulation of immune effector process GO:0002697 101 66 0,000 0,08337001 0,08816139 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,08458053 0,08940038 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,08458053 0,08935931 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,08458053 0,08931828 ! acute inflammatory response GO:0002526 92 68 0,000 0,08578952 0,09055342 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,08578952 0,09051188 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,08578952 0,09047038 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,08578952 0,09042892 ! rhythmic process GO:0048511 105 68 0,000 0,08578952 0,0903875 ! inorganic anion transport GO:0015698 93 68 0,000 0,08578952 0,09034611 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,08699699 0,09157578 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,08699699 0,09153389 ! response to drug GO:0042493 108 69 0,000 0,08699699 0,09149204 ! humoral immune response GO:0006959 86 70 0,000 0,08820293 0,09271789 ! amine transport GO:0015837 101 70 0,000 0,08820293 0,09267554 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,08820293 0,09263322 ! regulation of catabolic process GO:0009894 106 70 0,000 0,08820293 0,09259094 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,08940735 0,09381246 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,08940735 0,09376968 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,08940735 0,09372694 ! regulation of peptidase activity GO:0052547 106 72 0,000 0,09061025 0,09494468 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,09061025 0,09490145 ! negative regulation of transport GO:0051051 116 73 0,000 0,09181163 0,09611595 ! regulation of blood pressure GO:0008217 107 73 0,000 0,09181163 0,09607222 ! tube morphogenesis GO:0035239 118 73 0,000 0,09181163 0,09602853 ! mitochondrion organization GO:0007005 104 73 0,000 0,09181163 0,09598488 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,09181163 0,09594127 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,09301148 0,09715096 ! digestion GO:0007586 97 74 0,000 0,09301148 0,09710686 ! protein import into nucleus GO:0006606 118 74 0,000 0,09301148 0,0970628 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,09301148 0,09701878 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,09301148 0,0969748 ! blood coagulation GO:0007596 116 75 0,000 0,09420983 0,0981797 GO:0050817|coagulation, ! negative regulation of growth GO:0045926 123 75 0,000 0,09420983 0,09813524 ! response to nutrient GO:0007584 104 75 0,000 0,09420983 0,09809081 ! nuclear import GO:0051170 121 75 0,000 0,09420983 0,09804643 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,09420983 0,09800208 ! amine biosynthetic process GO:0009309 97 76 0,000 0,09540665 0,09920222 ! tRNA metabolic process GO:0006399 95 76 0,000 0,09540665 0,09915739 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,09540665 0,0991126 ! regulation of protein transport GO:0051223 114 76 0,000 0,09540665 0,09906786 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,09660197 0,10026378 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,09660197 0,10021855 ! regulation of DNA binding GO:0051101 119 77 0,000 0,09660197 0,10017337 ! gland development GO:0048732 148 77 0,000 0,09660197 0,10012822 ! sex differentiation GO:0007548 105 77 0,000 0,09660197 0,10008312 ! protein ubiquitination GO:0016567 125 77 0,000 0,09660197 0,10003806 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,09660197 0,09999304 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,09660197 0,09994806 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,09779577 0,10113771 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,09779577 0,10109226 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,09898807 0,10227877 ! cellular respiration GO:0045333 107 79 0,000 0,09898807 0,10223285 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,09898807 0,10218696 ! T cell activation GO:0042110 134 79 0,000 0,09898807 0,10214112 ! regulation of lyase activity GO:0051339 133 79 0,000 0,09898807 0,10209532 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,09898807 0,10204955 ! chromatin assembly GO:0031497 102 80 0,000 0,10017885 0,1032309 GO:0006334|nucleosome assembly, ! protein localization in nucleus GO:0034504 133 80 0,000 0,10017885 0,10318467 ! forebrain development GO:0030900 131 80 0,000 0,10017885 0,10313848 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,10136814 0,1043162 ! hemostasis GO:0007599 125 81 0,000 0,10136814 0,10426955 ! mRNA transport GO:0051028 121 81 0,000 0,10136814 0,10422294 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,10136814 0,10417637 ! vitamin metabolic process GO:0006766 103 81 0,000 0,10136814 0,10412984 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,10136814 0,10408335 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,10255591 0,10525596 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,10255591 0,10520901 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,10374219 0,10637853 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,10374219 0,10633112 ! regulation of defense response GO:0031347 117 84 0,000 0,10492697 0,10749756 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,10492697 0,1074497 ! sterol metabolic process GO:0016125 120 84 0,000 0,10492697 0,10740188 ! rRNA metabolic process GO:0016072 107 85 0,000 0,10611025 0,10856475 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,10611025 0,10851648 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,10611025 0,10846825 ! regulation of protein localization GO:0032880 132 85 0,000 0,10611025 0,10842007 ! regulation of membrane potential GO:0042391 128 85 0,000 0,10611025 0,10837192 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,10729203 0,10953026 ! cell cycle arrest GO:0007050 150 86 0,000 0,10729203 0,10948166 ! nucleosome organization GO:0034728 114 87 0,000 0,10847232 0,11063695 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,10847232 0,11058791 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,10847232 0,11053891 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,10847232 0,11048996 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,10847232 0,11044105 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,10847232 0,11039218 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,10965111 0,11154248 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,10965111 0,11149317 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,10965111 0,1114439 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,10965111 0,11139468 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,11082841 0,112541 ! reproductive developmental process GO:0003006 127 89 0,000 0,11082841 0,11249133 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,11082841 0,11244171 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,11082841 0,11239213 ! regulation of T cell activation GO:0050863 128 89 0,000 0,11082841 0,1123426 ! leukocyte differentiation GO:0002521 143 90 0,000 0,11200423 0,11348446 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,11200423 0,11343449 ! hormone metabolic process GO:0042445 121 90 0,000 0,11200423 0,11338456 ! ATP metabolic process GO:0046034 137 91 0,000 0,11317856 0,11452296 ! response to virus GO:0009615 122 91 0,000 0,11317856 0,1144726 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,1143514 0,11560801 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,1143514 0,11555721 ! cell fate commitment GO:0045165 141 92 0,000 0,1143514 0,11550646 ! positive regulation of immune response GO:0050778 121 92 0,000 0,1143514 0,11545576 ! DNA recombination GO:0006310 146 92 0,000 0,1143514 0,1154051 ! sulfur metabolic process GO:0006790 118 92 0,000 0,1143514 0,11535448 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,11552276 0,11648502 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,11552276 0,11643398 ! electron transport chain GO:0022900 123 94 0,000 0,11669263 0,11756157 ! regulation of binding GO:0051098 151 95 0,000 0,11786103 0,11868668 ! angiogenesis GO:0001525 149 95 0,000 0,11786103 0,11863473 ! carboxylic acid transport GO:0046942 147 95 0,000 0,11786103 0,11858284 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,11902795 0,11970454 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,11902795 0,11965222 ! protein maturation GO:0051604 129 96 0,000 0,11902795 0,11959995 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,12019339 0,12071825 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,12019339 0,12066556 ! calcium ion transport GO:0006816 167 99 0,000 0,12251985 0,12294749 ! extracellular structure organization GO:0043062 156 99 0,000 0,12251985 0,12289387 ! protein import GO:0017038 156 99 0,000 0,12251985 0,1228403 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,12368087 0,12395033 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,12368087 0,12389634 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,12368087 0,1238424 ! divalent metal ion transport GO:0070838 171 100 0,000 0,12368087 0,12378851 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,12368087 0,12373467 ! protein localization in organelle GO:0033365 161 100 0,000 0,12368087 0,12368087