pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a1/out-0.05-06-0.01-300-run-a1//th1-pval-1e-02-02-th2-pval-1e-01-11-th3-pval-1e-01-01-run-a1/go_data/3251-4-real-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! spindle assembly GO:0051225 5 5 3,000 7,686E-12 1,768E-08 ! natural killer cell mediated immunity GO:0002228 13 9 3,000 1,931E-10 2,22E-07 GO:0042267|natural killer cell mediated cytotoxicity, ! leukocyte mediated cytotoxicity GO:0001909 17 11 3,000 5,049E-10 3,871E-07 ! cell killing GO:0001906 20 14 3,000 1,528E-09 8,786E-07 ! spindle organization GO:0007051 37 30 3,000 4,131E-08 1,9E-05 ! lymphocyte mediated immunity GO:0002449 88 62 3,000 8,203E-07 3,144E-04 ! leukocyte mediated immunity GO:0002443 99 71 3,000 1,419E-06 4,662E-04 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 2,789E-06 8,018E-04 ! negative regulation of protein ubiquitination GO:0031397 7 5 1,000 1,371E-05 3,505E-03 ! positive regulation of viral genome replication GO:0045070 8 5 1,000 1,371E-05 3,154E-03 ! regulation of retroviral genome replication GO:0045091 6 5 1,000 1,371E-05 2,867E-03 ! nucleoside salvage GO:0043174 7 5 1,000 1,371E-05 2,628E-03 GO:0006166|purine ribonucleoside salvage, ! positive regulation of Rho GTPase activity GO:0032321 9 5 1,000 1,371E-05 2,426E-03 ! response to insulin stimulus GO:0032868 63 43 2,000 1,787E-05 2,937E-03 ! regulation of dopamine metabolic process GO:0042053 9 6 1,000 2,056E-05 3,152E-03 GO:0042069|regulation of catecholamine metabolic process, ! purine salvage GO:0043101 8 6 1,000 2,056E-05 2,955E-03 ! DNA topological change GO:0006265 8 6 1,000 2,056E-05 2,781E-03 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 1,000 2,056E-05 2,627E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 2,876E-05 3,481E-03 ! regulation of cellular amine metabolic process GO:0033238 10 7 1,000 2,876E-05 3,307E-03 ! regulation of focal adhesion formation GO:0051893 17 7 1,000 2,876E-05 3,15E-03 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 1,000 2,876E-05 3,006E-03 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 3,831E-05 3,831E-03 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 4,192E-05 4,018E-03 ! positive regulation of GTPase activity GO:0043547 21 9 1,000 4,923E-05 4,529E-03 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 1,000 4,923E-05 4,355E-03 ! regulation of stress fiber formation GO:0051492 20 9 1,000 4,923E-05 4,193E-03 ! DNA ligation GO:0006266 14 9 1,000 4,923E-05 4,044E-03 ! cellular metabolic compound salvage GO:0043094 11 9 1,000 4,923E-05 3,904E-03 ! purine base metabolic process GO:0006144 18 9 1,000 4,923E-05 3,774E-03 ! regulation of phosphatase activity GO:0010921 21 10 1,000 6,149E-05 4,562E-03 ! positive regulation of viral reproduction GO:0048524 15 10 1,000 6,149E-05 4,419E-03 ! regulation of actin filament bundle formation GO:0032231 21 10 1,000 6,149E-05 4,285E-03 ! protein homotetramerization GO:0051289 18 11 1,000 7,51E-05 5,08E-03 ! regulation of Rho GTPase activity GO:0032319 18 11 1,000 7,51E-05 4,935E-03 ! regulation of protein ubiquitination GO:0031396 19 15 1,000 1,43E-04 9,133E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 1,434E-04 8,913E-03 ! interphase GO:0051325 159 88 2,000 1,535E-04 9,291E-03 ! cellular response to unfolded protein GO:0034620 19 16 1,000 1,633E-04 9,628E-03 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of dephosphorylation GO:0035303 33 16 1,000 1,633E-04 9,387E-03 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 1,000 1,633E-04 9,158E-03 ! negative regulation of translation GO:0017148 22 16 1,000 1,633E-04 8,94E-03 ! regulation of viral genome replication GO:0045069 24 17 1,000 1,849E-04 9,889E-03 ! nucleobase metabolic process GO:0009112 31 17 1,000 1,849E-04 9,665E-03 ! synaptic vesicle transport GO:0048489 33 18 1,000 2,078E-04 0,0106234 ! apoptotic nuclear changes GO:0030262 24 19 1,000 2,321E-04 0,01160668 ! chromosome condensation GO:0030261 31 20 1,000 2,577E-04 0,01261279 ! microtubule-based transport GO:0010970 37 20 1,000 2,577E-04 0,01235002 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 2,847E-04 0,01336177 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 2,847E-04 0,01309453 ! purine ribonucleoside metabolic process GO:0046128 28 21 1,000 2,847E-04 0,01283778 GO:0042278|purine nucleoside metabolic process, ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 2,847E-04 0,0125909 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 3,129E-04 0,01357883 GO:0010810|regulation of cell-substrate adhesion, ! protein tetramerization GO:0051262 39 22 1,000 3,129E-04 0,01332737 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 3,425E-04 0,01432087 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 3,425E-04 0,01406514 ! regulation of viral reproduction GO:0050792 32 23 1,000 3,425E-04 0,01381839 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 3,425E-04 0,01358014 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 3,733E-04 0,01455306 ! fat cell differentiation GO:0045444 37 24 1,000 3,733E-04 0,01431051 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 4,055E-04 0,01528883 GO:0045936|negative regulation of phosphate metabolic process, ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 4,39E-04 0,01628395 ! negative regulation of protein modification process GO:0031400 50 26 1,000 4,39E-04 0,01602548 ! RNA export from nucleus GO:0006405 44 33 1,000 7,095E-04 0,02549889 ! nucleus organization GO:0006997 49 33 1,000 7,095E-04 0,0251066 ! female gamete generation GO:0007292 43 34 1,000 7,533E-04 0,02625258 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 7,533E-04 0,02586075 ! protein homooligomerization GO:0051260 52 35 1,000 7,984E-04 0,02700516 ! ribonucleoside metabolic process GO:0009119 48 37 1,000 8,924E-04 0,02974645 ! response to calcium ion GO:0051592 58 40 1,000 1,043E-03 0,03426603 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 1,043E-03 0,03378341 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 1,15E-03 0,03672057 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 1,205E-03 0,03795679 ! positive regulation of cell cycle GO:0045787 77 45 1,000 1,319E-03 0,04099205 ! response to UV GO:0009411 75 46 1,000 1,378E-03 0,04225334 ! negative regulation of immune system process GO:0002683 73 47 1,000 1,438E-03 0,0435191 ! nuclear export GO:0051168 69 48 1,000 1,499E-03 0,04478907 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 1,691E-03 0,04986858 ! nucleoside metabolic process GO:0009116 69 55 1,000 1,964E-03 0,05718137 ! chromosome segregation GO:0007059 83 57 1,000 2,108E-03 0,06059965 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 2,41E-03 0,06842857 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 2,488E-03 0,06979674 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 2,649E-03 0,07340778 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 2,649E-03 0,07253388 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 2,731E-03 0,07390268 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 2,731E-03 0,07304335 ! protein oligomerization GO:0051259 100 65 1,000 2,731E-03 0,07220377 ! regulation of actin filament-based process GO:0032970 99 66 1,000 2,815E-03 0,07356082 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 2,815E-03 0,07273429 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 2,985E-03 0,07627557 ! positive regulation of ligase activity GO:0051351 99 69 1,000 3,072E-03 0,07763313 ! response to metal ion GO:0010038 103 70 1,000 3,16E-03 0,0789907 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 3,16E-03 0,07814134 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 3,249E-03 0,07949346 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 3,249E-03 0,07865669 ! steroid biosynthetic process GO:0006694 94 71 1,000 3,249E-03 0,07783735 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 3,339E-03 0,07917868 GO:0045937|positive regulation of phosphate metabolic process, ! protein import into nucleus GO:0006606 118 74 1,000 3,524E-03 0,08269708 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 3,524E-03 0,08186175 ! regulation of ligase activity GO:0051340 114 75 1,000 3,618E-03 0,08320337 ! response to inorganic substance GO:0010035 115 75 1,000 3,618E-03 0,08237957 ! nuclear import GO:0051170 121 75 1,000 3,618E-03 0,08157193 ! response to unfolded protein GO:0006986 99 76 1,000 3,713E-03 0,08290331 ! positive regulation of protein modification process GO:0031401 107 78 1,000 3,906E-03 0,08638908 ! T cell activation GO:0042110 134 79 1,000 4,005E-03 0,08772545 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 4,105E-03 0,08906166 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 4,105E-03 0,08822931 ! regulation of GTPase activity GO:0043087 129 80 1,000 4,105E-03 0,08741237 ! response to protein stimulus GO:0051789 111 81 1,000 4,205E-03 0,08873899 ! regulation of cell adhesion GO:0030155 159 83 1,000 4,411E-03 0,09222274 ! establishment of RNA localization GO:0051236 128 88 1,000 4,944E-03 0,10243539 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! RNA localization GO:0006403 135 91 1,000 5,277E-03 0,10836687 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 5,505E-03 0,11204593 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 5,855E-03 0,11812819 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 5,855E-03 0,11710099 ! response to light stimulus GO:0009416 153 96 1,000 5,855E-03 0,1160915 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 5,992E-03 0,11780029 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 5,992E-03 0,11680198 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 5,992E-03 0,11582045 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 5,992E-03 0,11485528 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 5,992E-03 0,11390606 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 5,992E-03 0,11297241 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 5,992E-03 0,11205393 ! sleep GO:0030431 11 5 0,000 5,992E-03 0,11115027 ! negative regulation of bone resorption GO:0045779 10 5 0,000 5,992E-03 0,11026107 ! nucleotide-sugar transport GO:0015780 8 5 0,000 5,992E-03 0,10938598 ! regulation of interferon-beta production GO:0032648 5 5 0,000 5,992E-03 0,10852467 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 5,992E-03 0,10767682 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 5,992E-03 0,10684212 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 5,992E-03 0,10602026 ! tongue development GO:0043586 6 5 0,000 5,992E-03 0,10521094 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 5,992E-03 0,10441389 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 5,992E-03 0,10362882 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 5,992E-03 0,10285547 ! cobalt ion transport GO:0006824 9 5 0,000 5,992E-03 0,10209358 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 5,992E-03 0,10134289 ! SMAD protein complex assembly GO:0007183 9 5 0,000 5,992E-03 0,10060316 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 5,992E-03 0,09987416 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 5,992E-03 0,09915564 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 5,992E-03 0,09844738 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 5,992E-03 0,09774917 ! embryonic camera-type eye development GO:0031076 8 5 0,000 5,992E-03 0,0970608 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 5,992E-03 0,09638205 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 5,992E-03 0,09571273 ! adaptation of signaling pathway GO:0022401 7 5 0,000 5,992E-03 0,09505265 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 5,992E-03 0,0944016 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 5,992E-03 0,09375941 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 5,992E-03 0,0931259 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 5,992E-03 0,0925009 ! positive regulation of histone modification GO:0031058 5 5 0,000 5,992E-03 0,09188422 ! malate metabolic process GO:0006108 7 5 0,000 5,992E-03 0,09127572 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 5,992E-03 0,09067522 ! behavioral response to pain GO:0048266 7 5 0,000 5,992E-03 0,09008257 ! clathrin coat assembly GO:0048268 11 5 0,000 5,992E-03 0,08949762 ! phototransduction, visible light GO:0007603 6 5 0,000 5,992E-03 0,08892022 ! regulation of dopamine uptake GO:0051584 9 5 0,000 5,992E-03 0,08835022 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 5,992E-03 0,08778748 ! mating behavior GO:0007617 6 5 0,000 5,992E-03 0,08723186 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 5,992E-03 0,08668323 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 5,992E-03 0,08614146 ! rhythmic behavior GO:0007622 12 5 0,000 5,992E-03 0,08560642 ! copulation GO:0007620 7 5 0,000 5,992E-03 0,08507799 ! glial cell fate commitment GO:0021781 12 5 0,000 5,992E-03 0,08455603 ! protein maturation by protein folding GO:0022417 12 5 0,000 5,992E-03 0,08404045 ! embryonic hemopoiesis GO:0035162 10 5 0,000 5,992E-03 0,08353111 ! regulation of potassium ion transport GO:0043266 9 5 0,000 5,992E-03 0,08302791 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 5,992E-03 0,08253074 ! apoptotic cell clearance GO:0043277 13 5 0,000 5,992E-03 0,08203949 ! lipoprotein particle clearance GO:0034381 9 5 0,000 5,992E-03 0,08155404 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 5,992E-03 0,08107432 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 5,992E-03 0,0806002 ! response to protozoan GO:0001562 9 5 0,000 5,992E-03 0,08013159 ! positive regulation of glycolysis GO:0045821 11 5 0,000 5,992E-03 0,0796684 ! lymph vessel development GO:0001945 7 5 0,000 5,992E-03 0,07921054 ! endochondral ossification GO:0001958 12 5 0,000 5,992E-03 0,07875791 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 5,992E-03 0,07831042 ! parathyroid gland development GO:0060017 8 5 0,000 5,992E-03 0,07786799 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 5,992E-03 0,07743053 ! anagen GO:0042640 6 5 0,000 5,992E-03 0,07699795 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 5,992E-03 0,07657019 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 5,992E-03 0,07614715 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 5,992E-03 0,07572876 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 5,992E-03 0,07531494 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 5,992E-03 0,07490562 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 5,992E-03 0,07450072 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 5,992E-03 0,07410018 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 5,992E-03 0,07370392 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 5,992E-03 0,07331188 ! cardiac muscle fiber development GO:0048739 7 5 0,000 5,992E-03 0,07292399 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 5,992E-03 0,07254018 ! neutrophil mediated immunity GO:0002446 6 5 0,000 5,992E-03 0,07216039 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 5,992E-03 0,07178455 ! ovulation GO:0030728 6 5 0,000 5,992E-03 0,07141261 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 5,992E-03 0,0710445 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 5,992E-03 0,07068017 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 5,992E-03 0,07031956 ! response to pH GO:0009268 9 5 0,000 5,992E-03 0,06996261 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 5,992E-03 0,06960926 ! proline biosynthetic process GO:0006561 6 5 0,000 5,992E-03 0,06925947 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 5,992E-03 0,06891317 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 5,992E-03 0,06857032 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 5,992E-03 0,06823086 ! polyol catabolic process GO:0046174 7 5 0,000 5,992E-03 0,06789475 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 5,992E-03 0,06756193 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 5,992E-03 0,06723236 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 5,992E-03 0,06690599 ! sister chromatid cohesion GO:0007062 9 5 0,000 5,992E-03 0,06658277 ! nerve growth factor processing GO:0032455 7 5 0,000 5,992E-03 0,06626266 ! urea metabolic process GO:0019627 6 5 0,000 5,992E-03 0,06594562 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 5,992E-03 0,06563159 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 5,992E-03 0,06532054 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 5,992E-03 0,06501242 ! neutrophil activation GO:0042119 5 5 0,000 5,992E-03 0,0647072 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 5,992E-03 0,06440483 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 5,992E-03 0,06410527 ! response to food GO:0032094 5 5 0,000 5,992E-03 0,06380849 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 5,992E-03 0,06351444 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 5,992E-03 0,06322309 ! paraxial mesoderm development GO:0048339 9 5 0,000 5,992E-03 0,0629344 ! forebrain neuron development GO:0021884 7 5 0,000 5,992E-03 0,06264833 ! melanosome organization GO:0032438 7 5 0,000 5,992E-03 0,06236486 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 5,992E-03 0,06208394 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 5,992E-03 0,06180553 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 5,992E-03 0,06152961 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 5,992E-03 0,06125615 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 5,992E-03 0,0609851 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 5,992E-03 0,06071645 ! nucleoside transport GO:0015858 6 5 0,000 5,992E-03 0,06045015 ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 5,992E-03 0,06018617 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 5,992E-03 0,05992449 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 5,992E-03 0,05966508 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 5,992E-03 0,0594079 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 5,992E-03 0,05915293 ! early endosome to late endosome transport GO:0045022 11 5 0,000 5,992E-03 0,05890014 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 5,992E-03 0,0586495 ! depyrimidination GO:0045008 8 5 0,000 5,992E-03 0,05840099 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 5,992E-03 0,05815457 ! 5S class rRNA transcription GO:0042791 8 5 0,000 5,992E-03 0,05791023 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 5,992E-03 0,05766792 ! regulation of centrosome cycle GO:0046605 7 5 0,000 5,992E-03 0,05742764 ! neuronal ion channel clustering GO:0045161 7 5 0,000 5,992E-03 0,05718935 ! sodium ion homeostasis GO:0055078 6 5 0,000 5,992E-03 0,05695303 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 5,992E-03 0,05671866 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 5,992E-03 0,0564862 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 5,992E-03 0,05625565 ! monocyte differentiation GO:0030224 8 5 0,000 5,992E-03 0,05602697 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 5,992E-03 0,05580014 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 5,992E-03 0,05557514 ! centrosome duplication GO:0051298 5 5 0,000 5,992E-03 0,05535194 ! response to UV-C GO:0010225 6 5 0,000 5,992E-03 0,05513053 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 5,992E-03 0,05491089 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 5,992E-03 0,05469299 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 5,992E-03 0,05447681 ! regulation of dendrite development GO:0050773 12 5 0,000 5,992E-03 0,05426234 ! peptidyl-arginine modification GO:0018195 7 5 0,000 5,992E-03 0,05404954 ! positive regulation of organ growth GO:0046622 6 5 0,000 5,992E-03 0,05383841 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 5,992E-03 0,05362892 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 5,992E-03 0,05342106 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 5,992E-03 0,0532148 ! regulation of dopamine secretion GO:0014059 12 5 0,000 5,992E-03 0,05301013 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 5,992E-03 0,05280703 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 5,992E-03 0,05260547 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 5,992E-03 0,05240545 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 5,992E-03 0,05220695 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 5,992E-03 0,05200994 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 5,992E-03 0,05181441 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 5,992E-03 0,05162035 ! neural tube patterning GO:0021532 6 5 0,000 5,992E-03 0,05142774 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 5,992E-03 0,05123656 ! histone demethylation GO:0016577 9 5 0,000 5,992E-03 0,05104679 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 5,992E-03 0,05085843 ! regulation of sterol transport GO:0032371 7 5 0,000 5,992E-03 0,05067145 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 5,992E-03 0,05048584 ! enteric nervous system development GO:0048484 8 5 0,000 5,992E-03 0,05030158 ! establishment of planar polarity GO:0001736 6 5 0,000 5,992E-03 0,05011867 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 5,992E-03 0,04993708 ! muscle cell proliferation GO:0033002 8 5 0,000 5,992E-03 0,0497568 ! transcription termination GO:0006353 8 5 0,000 5,992E-03 0,04957782 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 5,992E-03 0,04940012 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 5,992E-03 0,04922369 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 5,992E-03 0,04904852 ! regulation of respiratory burst GO:0060263 8 5 0,000 5,992E-03 0,04887459 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 5,992E-03 0,04870189 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 5,992E-03 0,0485304 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 5,992E-03 0,04836012 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 5,992E-03 0,04819103 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 5,992E-03 0,04802311 ! apical protein localization GO:0045176 6 5 0,000 5,992E-03 0,04785637 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 5,992E-03 0,04769077 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 5,992E-03 0,04752632 ! galactolipid metabolic process GO:0019374 7 5 0,000 5,992E-03 0,047363 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 5,992E-03 0,0472008 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 5,992E-03 0,04703971 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 5,992E-03 0,04687971 ! triglyceride catabolic process GO:0019433 6 5 0,000 5,992E-03 0,04672079 ! glial cell migration GO:0008347 10 5 0,000 5,992E-03 0,04656295 ! determination of adult lifespan GO:0008340 8 5 0,000 5,992E-03 0,04640617 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 5,992E-03 0,04625045 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 5,992E-03 0,04609576 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 5,992E-03 0,04594211 ! somatic stem cell maintenance GO:0035019 13 5 0,000 5,992E-03 0,04578948 ! cerebellar cortex formation GO:0021697 6 5 0,000 5,992E-03 0,04563786 ! neural plate development GO:0001840 6 5 0,000 5,992E-03 0,04548724 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 5,992E-03 0,04533761 ! regulation of sensory perception GO:0051931 6 5 0,000 5,992E-03 0,04518896 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 5,992E-03 0,04504129 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 5,992E-03 0,04489457 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 5,992E-03 0,04474881 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 5,992E-03 0,04460399 ! sensory cilium assembly GO:0035058 6 5 0,000 5,992E-03 0,04446011 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 5,992E-03 0,04431715 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 5,992E-03 0,04417511 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 5,992E-03 0,04403397 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 5,992E-03 0,04389374 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 5,992E-03 0,04375439 ! protein amino acid prenylation GO:0018346 9 5 0,000 5,992E-03 0,04361593 ! organ regeneration GO:0031100 7 5 0,000 5,992E-03 0,04347834 ! NAD biosynthetic process GO:0009435 7 5 0,000 5,992E-03 0,04334162 ! carnitine metabolic process GO:0009437 5 5 0,000 5,992E-03 0,04320575 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 5,992E-03 0,04307073 ! cellular anion homeostasis GO:0030002 6 5 0,000 5,992E-03 0,04293655 GO:0055081|anion homeostasis, ! protein import GO:0017038 156 99 1,000 6,215E-03 0,04439447 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 6,215E-03 0,04425703 ! regulation of translation GO:0006417 151 100 1,000 6,337E-03 0,04498838 ! Ras protein signal transduction GO:0007265 162 100 1,000 6,337E-03 0,04484996 ! protein localization in organelle GO:0033365 161 100 1,000 6,337E-03 0,04471238 ! tRNA transcription GO:0009304 11 6 0,000 7,187E-03 0,05054956 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 7,187E-03 0,05039544 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 7,187E-03 0,05024226 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 7,187E-03 0,05009001 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 7,187E-03 0,04993869 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 7,187E-03 0,04978827 ! regulation of helicase activity GO:0051095 11 6 0,000 7,187E-03 0,04963875 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 7,187E-03 0,04949013 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 7,187E-03 0,0493424 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 7,187E-03 0,04919555 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 7,187E-03 0,04904957 ! positive regulation of axon extension GO:0045773 8 6 0,000 7,187E-03 0,04890445 ! prostate gland development GO:0030850 9 6 0,000 7,187E-03 0,04876019 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 7,187E-03 0,04861678 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 7,187E-03 0,04847421 ! forebrain neuron differentiation GO:0021879 9 6 0,000 7,187E-03 0,04833247 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 7,187E-03 0,04819156 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 7,187E-03 0,04805147 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 7,187E-03 0,04791219 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 7,187E-03 0,04777371 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 7,187E-03 0,04763604 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 7,187E-03 0,04749915 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 7,187E-03 0,04736305 ! neuron adhesion GO:0007158 9 6 0,000 7,187E-03 0,04722773 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 7,187E-03 0,04709318 ! establishment of tissue polarity GO:0007164 7 6 0,000 7,187E-03 0,04695939 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 7,187E-03 0,04682636 ! signal peptide processing GO:0006465 8 6 0,000 7,187E-03 0,04669408 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 7,187E-03 0,04656255 ! mRNA stabilization GO:0048255 15 6 0,000 7,187E-03 0,04643176 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 7,187E-03 0,04630169 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 7,187E-03 0,04617236 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 7,187E-03 0,04604375 ! opsonization GO:0008228 8 6 0,000 7,187E-03 0,04591585 ! erythrocyte maturation GO:0043249 6 6 0,000 7,187E-03 0,04578866 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 7,187E-03 0,04566217 ! protein amino acid dealkylation GO:0008214 11 6 0,000 7,187E-03 0,04553638 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 7,187E-03 0,04541128 ! photoreceptor cell development GO:0042461 10 6 0,000 7,187E-03 0,04528686 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 7,187E-03 0,04516313 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 7,187E-03 0,04504007 ! mechanosensory behavior GO:0007638 8 6 0,000 7,187E-03 0,04491768 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 7,187E-03 0,04479595 ! negative regulation of endocytosis GO:0045806 8 6 0,000 7,187E-03 0,04467488 ! response to interferon-gamma GO:0034341 12 6 0,000 7,187E-03 0,04455446 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 7,187E-03 0,04443469 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 7,187E-03 0,04431556 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 7,187E-03 0,04419707 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 7,187E-03 0,04407921 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 7,187E-03 0,04396198 ! cGMP-mediated signaling GO:0019934 10 6 0,000 7,187E-03 0,04384537 ! activation of MAPKKK activity GO:0000185 10 6 0,000 7,187E-03 0,04372938 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 7,187E-03 0,043614 ! thymic T cell selection GO:0045061 12 6 0,000 7,187E-03 0,04349922 ! protein lipoylation GO:0009249 10 6 0,000 7,187E-03 0,04338505 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 7,187E-03 0,04327148 ! pigment granule organization GO:0048753 11 6 0,000 7,187E-03 0,0431585 ! drug transport GO:0015893 6 6 0,000 7,187E-03 0,04304611 ! cysteine metabolic process GO:0006534 7 6 0,000 7,187E-03 0,0429343 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 7,187E-03 0,04282307 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 7,187E-03 0,04271242 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 7,187E-03 0,04260233 ! histidine metabolic process GO:0006547 6 6 0,000 7,187E-03 0,04249281 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 7,187E-03 0,04238386 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 7,187E-03 0,04227546 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 7,187E-03 0,04216761 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 7,187E-03 0,04206032 ! adenohypophysis development GO:0021984 10 6 0,000 7,187E-03 0,04195357 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 7,187E-03 0,04184735 ! hyperosmotic response GO:0006972 8 6 0,000 7,187E-03 0,04174168 ! microtubule nucleation GO:0007020 10 6 0,000 7,187E-03 0,04163654 ! ER overload response GO:0006983 7 6 0,000 7,187E-03 0,04153192 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 7,187E-03 0,04142783 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 7,187E-03 0,04132426 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 7,187E-03 0,04122121 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 7,187E-03 0,04111867 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 7,187E-03 0,04101664 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 7,187E-03 0,04091511 ! response to dietary excess GO:0002021 7 6 0,000 7,187E-03 0,04081409 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 7,187E-03 0,04071356 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 7,187E-03 0,04061353 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 7,187E-03 0,04051398 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 7,187E-03 0,04041493 ! glycerol ether catabolic process GO:0044269 8 6 0,000 7,187E-03 0,04031635 GO:0046464|acylglycerol catabolic process, ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 7,187E-03 0,04021826 ! neuron apoptosis GO:0051402 8 6 0,000 7,187E-03 0,04012064 ! organic alcohol transport GO:0015850 9 6 0,000 7,187E-03 0,0400235 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 7,187E-03 0,03992682 ! T cell mediated immunity GO:0002456 12 6 0,000 7,187E-03 0,03983061 ! male sex determination GO:0030238 9 6 0,000 7,187E-03 0,03973487 ! carnitine transport GO:0015879 8 6 0,000 7,187E-03 0,03963958 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 7,187E-03 0,03954475 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 7,187E-03 0,03945037 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 7,187E-03 0,03935644 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 7,187E-03 0,03926296 ! positive regulation of exocytosis GO:0045921 6 6 0,000 7,187E-03 0,03916992 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 7,187E-03 0,03907732 ! parturition GO:0007567 12 6 0,000 7,187E-03 0,03898515 ! negative regulation of translational initiation GO:0045947 7 6 0,000 7,187E-03 0,03889342 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 7,187E-03 0,03880212 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 7,187E-03 0,03871125 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 7,187E-03 0,03862081 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 7,187E-03 0,03853078 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 7,187E-03 0,03844117 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 7,187E-03 0,03835198 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 7,187E-03 0,03826321 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 7,187E-03 0,03817484 ! macrophage differentiation GO:0030225 10 6 0,000 7,187E-03 0,03808688 ! astrocyte development GO:0014002 14 6 0,000 7,187E-03 0,03799932 ! hyaluronan metabolic process GO:0030212 6 6 0,000 7,187E-03 0,03791217 ! purine base biosynthetic process GO:0009113 14 6 0,000 7,187E-03 0,03782541 ! interaction with symbiont GO:0051702 8 6 0,000 7,187E-03 0,03773905 ! anterograde axon cargo transport GO:0008089 8 6 0,000 7,187E-03 0,03765309 ! skeletal muscle contraction GO:0003009 6 6 0,000 7,187E-03 0,03756751 ! eating behavior GO:0042755 6 6 0,000 7,187E-03 0,03748232 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 7,187E-03 0,03739752 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 7,187E-03 0,0373131 ! response to copper ion GO:0046688 9 6 0,000 7,187E-03 0,03722907 ! response to exogenous dsRNA GO:0043330 8 6 0,000 7,187E-03 0,0371454 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 7,187E-03 0,03706212 ! establishment of melanosome localization GO:0032401 9 6 0,000 7,187E-03 0,03697921 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 7,187E-03 0,03689666 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 7,187E-03 0,03681449 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 7,187E-03 0,03673268 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 7,187E-03 0,03665123 ! nucleoside catabolic process GO:0009164 6 6 0,000 7,187E-03 0,03657014 ! gas homeostasis GO:0033483 11 6 0,000 7,187E-03 0,03648941 ! hair follicle maturation GO:0048820 7 6 0,000 7,187E-03 0,03640904 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 7,187E-03 0,03632902 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 7,187E-03 0,03624935 ! Schwann cell development GO:0014044 14 6 0,000 7,187E-03 0,03617003 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 7,187E-03 0,03609106 ! dendrite morphogenesis GO:0048813 9 6 0,000 7,187E-03 0,03601243 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 7,187E-03 0,03593414 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 7,187E-03 0,03585619 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 7,187E-03 0,03577858 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 7,187E-03 0,03570131 ! histone ubiquitination GO:0016574 7 6 0,000 7,187E-03 0,03562436 ! regulation of meiosis GO:0040020 10 6 0,000 7,187E-03 0,03554775 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 7,187E-03 0,03547147 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 7,187E-03 0,03539551 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 7,187E-03 0,03531988 ! regulation of mast cell activation GO:0033003 6 6 0,000 7,187E-03 0,03524457 ! membrane to membrane docking GO:0022614 12 6 0,000 7,187E-03 0,03516958 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 7,187E-03 0,03509491 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 7,187E-03 0,03502056 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 7,187E-03 0,03494652 ! receptor internalization GO:0031623 9 6 0,000 7,187E-03 0,0348728 ! neutrophil homeostasis GO:0001780 6 6 0,000 7,187E-03 0,03479938 ! coenzyme A metabolic process GO:0015936 9 6 0,000 7,187E-03 0,03472627 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 7,187E-03 0,03465347 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 7,187E-03 0,03458097 ! protein deubiquitination GO:0016579 8 6 0,000 7,187E-03 0,03450878 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 7,187E-03 0,03443689 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 7,187E-03 0,03436529 ! peptidyl-histidine modification GO:0018202 9 6 0,000 7,187E-03 0,03429399 ! axonal fasciculation GO:0007413 9 6 0,000 7,187E-03 0,03422299 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 7,187E-03 0,03415228 ! thiamin metabolic process GO:0006772 6 6 0,000 7,187E-03 0,03408187 ! midbrain development GO:0030901 6 6 0,000 7,187E-03 0,03401174 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 7,187E-03 0,0339419 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 7,187E-03 0,03387235 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 7,187E-03 0,03380308 ! progesterone metabolic process GO:0042448 8 6 0,000 7,187E-03 0,03373409 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 7,187E-03 0,03366539 ! glycolipid catabolic process GO:0019377 13 6 0,000 7,187E-03 0,03359696 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 7,187E-03 0,03352881 ! positive regulation of glucose import GO:0046326 6 6 0,000 7,187E-03 0,03346094 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 7,187E-03 0,03339334 ! adult feeding behavior GO:0008343 6 6 0,000 7,187E-03 0,03332602 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 7,187E-03 0,03325896 ! blastocyst growth GO:0001832 15 6 0,000 7,187E-03 0,03319218 ! pigment granule transport GO:0051904 12 6 0,000 7,187E-03 0,03312566 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 7,187E-03 0,03305941 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 7,187E-03 0,03299342 ! catecholamine transport GO:0051937 7 6 0,000 7,187E-03 0,0329277 ! organ or tissue specific immune response GO:0002251 7 6 0,000 7,187E-03 0,03286224 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 7,187E-03 0,03279703 ! negative regulation of B cell activation GO:0050869 9 6 0,000 7,187E-03 0,03273209 ! protein prenylation GO:0018342 10 6 0,000 7,187E-03 0,0326674 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 7,187E-03 0,03260297 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 7,187E-03 0,03253879 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 7,187E-03 0,03247486 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 7,187E-03 0,03241119 ! positive regulation of coagulation GO:0050820 11 6 0,000 7,187E-03 0,03234776 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 8,38E-03 0,03764381 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 8,38E-03 0,03757043 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 8,38E-03 0,03749734 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 8,38E-03 0,03742453 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 8,38E-03 0,037352 ! synaptonemal complex assembly GO:0007130 10 7 0,000 8,38E-03 0,03727975 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 8,38E-03 0,03720778 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 8,38E-03 0,03713609 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 8,38E-03 0,03706468 ! reproductive behavior GO:0019098 12 7 0,000 8,38E-03 0,03699354 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 8,38E-03 0,03692267 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 8,38E-03 0,03685207 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 8,38E-03 0,03678174 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 8,38E-03 0,03671168 ! oligopeptide transport GO:0006857 11 7 0,000 8,38E-03 0,03664189 ! protein amino acid sulfation GO:0006477 9 7 0,000 8,38E-03 0,03657236 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 8,38E-03 0,03650309 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 8,38E-03 0,03643409 ! RNA methylation GO:0001510 11 7 0,000 8,38E-03 0,03636534 ! pericardium development GO:0060039 8 7 0,000 8,38E-03 0,03629686 ! macrophage chemotaxis GO:0048246 10 7 0,000 8,38E-03 0,03622863 ! fibril organization GO:0043206 13 7 0,000 8,38E-03 0,03616066 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 8,38E-03 0,03609294 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 8,38E-03 0,03602548 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 8,38E-03 0,03595827 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 8,38E-03 0,03589131 ! lipoprotein transport GO:0042953 9 7 0,000 8,38E-03 0,0358246 ! cerebral cortex cell migration GO:0021795 11 7 0,000 8,38E-03 0,03575813 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 8,38E-03 0,03569191 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 8,38E-03 0,03562594 ! estrogen metabolic process GO:0008210 14 7 0,000 8,38E-03 0,03556021 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 8,38E-03 0,03549472 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 8,38E-03 0,03542947 ! chemosensory behavior GO:0007635 9 7 0,000 8,38E-03 0,03536446 ! microtubule bundle formation GO:0001578 8 7 0,000 8,38E-03 0,03529969 ! T-helper 1 type immune response GO:0042088 11 7 0,000 8,38E-03 0,03523516 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 8,38E-03 0,03517086 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 8,38E-03 0,0351068 ! leukocyte degranulation GO:0043299 10 7 0,000 8,38E-03 0,03504297 ! bile acid and bile salt transport GO:0015721 9 7 0,000 8,38E-03 0,03497937 ! reflex GO:0060004 12 7 0,000 8,38E-03 0,034916 ! positive regulation of isotype switching GO:0045830 15 7 0,000 8,38E-03 0,03485286 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 8,38E-03 0,03478995 ! protein-cofactor linkage GO:0018065 13 7 0,000 8,38E-03 0,03472727 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 8,38E-03 0,03466481 ! glycerolipid catabolic process GO:0046503 9 7 0,000 8,38E-03 0,03460257 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 8,38E-03 0,03454056 ! spinal cord patterning GO:0021511 7 7 0,000 8,38E-03 0,03447877 ! hemoglobin metabolic process GO:0020027 10 7 0,000 8,38E-03 0,0344172 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 8,38E-03 0,03435585 ! adrenal gland development GO:0030325 17 7 0,000 8,38E-03 0,03429472 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 8,38E-03 0,03423381 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 8,38E-03 0,03417311 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 8,38E-03 0,03411262 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 8,38E-03 0,03405235 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 8,38E-03 0,0339923 ! endosome organization GO:0007032 10 7 0,000 8,38E-03 0,03393245 ! thyroid hormone generation GO:0006590 11 7 0,000 8,38E-03 0,03387282 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 8,38E-03 0,03381339 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 8,38E-03 0,03375417 ! regulation of pigmentation during development GO:0048070 15 7 0,000 8,38E-03 0,03369516 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 8,38E-03 0,03363636 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 8,38E-03 0,03357776 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 8,38E-03 0,03351936 ! galactose metabolic process GO:0006012 10 7 0,000 8,38E-03 0,03346117 ! vesicle fusion GO:0006906 15 7 0,000 8,38E-03 0,03340318 ! intracellular pH reduction GO:0051452 10 7 0,000 8,38E-03 0,03334538 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 8,38E-03 0,03328779 ! organ growth GO:0035265 11 7 0,000 8,38E-03 0,0332304 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 8,38E-03 0,03317321 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 8,38E-03 0,03311621 ! Rac protein signal transduction GO:0016601 7 7 0,000 8,38E-03 0,0330594 ! retinol metabolic process GO:0042572 9 7 0,000 8,38E-03 0,0330028 ! behavioral fear response GO:0001662 13 7 0,000 8,38E-03 0,03294638 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 8,38E-03 0,03289016 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 8,38E-03 0,03283413 ! rRNA modification GO:0000154 12 7 0,000 8,38E-03 0,03277829 ! protein heterooligomerization GO:0051291 10 7 0,000 8,38E-03 0,03272264 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 8,38E-03 0,03266717 ! response to UV-B GO:0010224 11 7 0,000 8,38E-03 0,0326119 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 8,38E-03 0,03255681 ! protein retention in ER lumen GO:0006621 12 7 0,000 8,38E-03 0,03250191 ! intermediate filament organization GO:0045109 11 7 0,000 8,38E-03 0,03244719 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 8,38E-03 0,03239266 ! cardiac muscle cell development GO:0055013 9 7 0,000 8,38E-03 0,03233831 ! fibrinolysis GO:0042730 9 7 0,000 8,38E-03 0,03228414 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 8,38E-03 0,03223015 ! regulation of circadian rhythm GO:0042752 11 7 0,000 8,38E-03 0,03217635 ! B cell lineage commitment GO:0002326 17 7 0,000 8,38E-03 0,03212272 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 8,38E-03 0,03206927 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 8,38E-03 0,032016 ! response to tropane GO:0014073 13 7 0,000 8,38E-03 0,03196291 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 8,38E-03 0,03190999 ! melanosome localization GO:0032400 10 7 0,000 8,38E-03 0,03185724 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 8,38E-03 0,03180467 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 8,38E-03 0,03175228 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 8,38E-03 0,03170005 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 8,38E-03 0,031648 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 8,38E-03 0,03159612 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 8,38E-03 0,03154441 ! mast cell activation GO:0045576 9 7 0,000 8,38E-03 0,03149286 ! multicellular organismal aging GO:0010259 11 7 0,000 8,38E-03 0,03144149 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 8,38E-03 0,03139028 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 8,38E-03 0,03133924 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 8,38E-03 0,03128836 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 8,38E-03 0,03123765 ! establishment of nucleus localization GO:0040023 13 7 0,000 8,38E-03 0,03118711 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 8,38E-03 0,03113672 ! T cell lineage commitment GO:0002360 12 7 0,000 8,38E-03 0,0310865 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 8,38E-03 0,03103644 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 8,38E-03 0,03098655 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 8,38E-03 0,03093681 ! regulation of lipid transport GO:0032368 13 7 0,000 8,38E-03 0,03088723 ! response to tumor cell GO:0002347 12 7 0,000 8,38E-03 0,03083781 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 8,38E-03 0,03078855 ! neuroblast proliferation GO:0007405 13 7 0,000 8,38E-03 0,03073945 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 8,38E-03 0,0306905 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 8,38E-03 0,0306417 ! peptidyl-threonine modification GO:0018210 18 7 0,000 8,38E-03 0,03059307 ! diuresis GO:0030146 12 7 0,000 8,38E-03 0,03054458 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 8,38E-03 0,03049625 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 8,38E-03 0,03044808 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 8,38E-03 0,03040005 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 8,38E-03 0,03035218 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 8,38E-03 0,03030445 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 8,38E-03 0,03025688 ! melanin biosynthetic process GO:0042438 8 7 0,000 8,38E-03 0,03020946 ! regulation of synaptogenesis GO:0051963 10 7 0,000 8,38E-03 0,03016218 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 8,38E-03 0,03011505 ! dopamine biosynthetic process GO:0042416 15 7 0,000 8,38E-03 0,03006807 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 8,38E-03 0,03002123 ! lymph node development GO:0048535 9 7 0,000 8,38E-03 0,02997454 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 8,38E-03 0,029928 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 8,38E-03 0,0298816 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 8,38E-03 0,02983534 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 8,38E-03 0,02978923 ! endosome to lysosome transport GO:0008333 10 7 0,000 8,38E-03 0,02974326 ! ATP catabolic process GO:0006200 10 7 0,000 8,38E-03 0,02969743 ! establishment of pigment granule localization GO:0051905 13 7 0,000 8,38E-03 0,02965174 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 8,38E-03 0,02960619 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 8,38E-03 0,02956079 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 8,38E-03 0,02951552 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 8,38E-03 0,02947039 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 8,38E-03 0,02942539 ! muscle adaptation GO:0043500 12 7 0,000 8,38E-03 0,02938054 ! amino sugar catabolic process GO:0046348 9 7 0,000 8,38E-03 0,02933582 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 8,38E-03 0,02929123 ! retina homeostasis GO:0001895 9 7 0,000 8,38E-03 0,02924679 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 8,38E-03 0,02920247 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 8,38E-03 0,02915829 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 8,38E-03 0,02911425 ! behavioral response to nicotine GO:0035095 11 7 0,000 8,38E-03 0,02907034 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 8,38E-03 0,02902655 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 8,38E-03 0,02898291 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 9,571E-03 0,03305468 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 9,571E-03 0,03300513 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 9,571E-03 0,03295572 ! axon extension GO:0048675 11 8 0,000 9,571E-03 0,03290646 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 9,571E-03 0,03285734 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 9,571E-03 0,03280837 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 9,571E-03 0,03275955 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 9,571E-03 0,03271088 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 9,571E-03 0,03266234 ! cell proliferation in forebrain GO:0021846 10 8 0,000 9,571E-03 0,03261395 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 9,571E-03 0,03256571 ! phosphate transport GO:0006817 10 8 0,000 9,571E-03 0,03251761 ! N-glycan processing GO:0006491 12 8 0,000 9,571E-03 0,03246965 ! Golgi to endosome transport GO:0006895 16 8 0,000 9,571E-03 0,03242183 ! UTP metabolic process GO:0046051 8 8 0,000 9,571E-03 0,03237415 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 9,571E-03 0,03232661 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 9,571E-03 0,03227921 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 9,571E-03 0,03223195 ! neurotransmitter uptake GO:0001504 10 8 0,000 9,571E-03 0,03218482 ! succinate metabolic process GO:0006105 14 8 0,000 9,571E-03 0,03213784 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 9,571E-03 0,03209099 ! smoothened signaling pathway GO:0007224 8 8 0,000 9,571E-03 0,03204428 ! membrane hyperpolarization GO:0060081 10 8 0,000 9,571E-03 0,0319977 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 9,571E-03 0,03195126 ! keratinocyte proliferation GO:0043616 12 8 0,000 9,571E-03 0,03190496 ! middle ear morphogenesis GO:0042474 9 8 0,000 9,571E-03 0,03185878 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 9,571E-03 0,03181274 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 9,571E-03 0,03176684 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 9,571E-03 0,03172107 ! ganglioside metabolic process GO:0001573 15 8 0,000 9,571E-03 0,03167542 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 9,571E-03 0,03162991 ! pseudouridine synthesis GO:0001522 9 8 0,000 9,571E-03 0,03158453 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 9,571E-03 0,03153928 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 9,571E-03 0,03149416 ! endothelial cell differentiation GO:0045446 14 8 0,000 9,571E-03 0,03144917 ! ceramide biosynthetic process GO:0046513 9 8 0,000 9,571E-03 0,03140431 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 9,571E-03 0,03135957 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 9,571E-03 0,03131496 ! astrocyte differentiation GO:0048708 16 8 0,000 9,571E-03 0,03127048 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 9,571E-03 0,03122613 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 9,571E-03 0,0311819 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 9,571E-03 0,03113779 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 9,571E-03 0,03109381 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 9,571E-03 0,03104996 ! melanin metabolic process GO:0006582 12 8 0,000 9,571E-03 0,03100622 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 9,571E-03 0,03096262 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 9,571E-03 0,03091913 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 9,571E-03 0,03087576 ! macrophage activation GO:0042116 12 8 0,000 9,571E-03 0,03083252 ! regulation of type I interferon production GO:0032479 8 8 0,000 9,571E-03 0,0307894 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 9,571E-03 0,0307464 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 9,571E-03 0,03070351 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 9,571E-03 0,03066075 ! regulation of vascular permeability GO:0043114 12 8 0,000 9,571E-03 0,03061811 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 9,571E-03 0,03057558 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 9,571E-03 0,03053318 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 9,571E-03 0,03049089 ! ruffle organization GO:0031529 11 8 0,000 9,571E-03 0,03044871 ! osteoblast development GO:0002076 13 8 0,000 9,571E-03 0,03040666 ! lens development in camera-type eye GO:0002088 10 8 0,000 9,571E-03 0,03036472 ! positive regulation of vasodilation GO:0045909 12 8 0,000 9,571E-03 0,03032289 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 9,571E-03 0,03028118 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 9,571E-03 0,03023959 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 9,571E-03 0,03019811 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 9,571E-03 0,03015674 ! Schwann cell differentiation GO:0014037 17 8 0,000 9,571E-03 0,03011548 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 9,571E-03 0,03007434 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 9,571E-03 0,03003331 ! regulation of gliogenesis GO:0014013 20 8 0,000 9,571E-03 0,0299924 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 9,571E-03 0,02995159 ! oligodendrocyte development GO:0014003 8 8 0,000 9,571E-03 0,0299109 ! segment specification GO:0007379 10 8 0,000 9,571E-03 0,02987031 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 9,571E-03 0,02982984 ! cellular extravasation GO:0045123 11 8 0,000 9,571E-03 0,02978947 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 9,571E-03 0,02974922 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 9,571E-03 0,02970907 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 9,571E-03 0,02966903 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 9,571E-03 0,0296291 ! snRNA metabolic process GO:0016073 10 8 0,000 9,571E-03 0,02958927 GO:0016180|snRNA processing, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 0,000 9,571E-03 0,02954956 ! regulation of interleukin-4 production GO:0032673 16 8 0,000 9,571E-03 0,02950995 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 9,571E-03 0,02947044 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 9,571E-03 0,02943104 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 9,571E-03 0,02939175 ! nucleosome disassembly GO:0006337 12 8 0,000 9,571E-03 0,02935256 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 9,571E-03 0,02931347 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 9,571E-03 0,02927449 ! icosanoid secretion GO:0032309 12 8 0,000 9,571E-03 0,02923562 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 9,571E-03 0,02919684 ! leukocyte activation during immune response GO:0002366 13 8 0,000 9,571E-03 0,02915817 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 9,571E-03 0,0291196 ! cerebellum morphogenesis GO:0021587 9 8 0,000 9,571E-03 0,02908114 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 9,571E-03 0,02904277 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 9,571E-03 0,02900451 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 9,571E-03 0,02896634 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 9,571E-03 0,02892828 ! sterol catabolic process GO:0016127 9 8 0,000 9,571E-03 0,02889031 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 9,571E-03 0,02885245 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 9,571E-03 0,02881469 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 9,571E-03 0,02877702 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 9,571E-03 0,02873945 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 9,571E-03 0,02870198 ! prophase GO:0051324 11 8 0,000 9,571E-03 0,02866461 ! S phase GO:0051320 8 8 0,000 9,571E-03 0,02862733 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 9,571E-03 0,02859016 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 9,571E-03 0,02855307 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 9,571E-03 0,02851609 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 9,571E-03 0,0284792 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 9,571E-03 0,0284424 ! hormone catabolic process GO:0042447 13 8 0,000 9,571E-03 0,0284057 ! quaternary ammonium group transport GO:0015697 10 8 0,000 9,571E-03 0,0283691 ! myeloid cell homeostasis GO:0002262 8 8 0,000 9,571E-03 0,02833259 ! regulation of fibrinolysis GO:0051917 13 8 0,000 9,571E-03 0,02829617 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 9,571E-03 0,02825985 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 9,571E-03 0,02822361 ! regulation of telomere maintenance GO:0032204 10 8 0,000 9,571E-03 0,02818748 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 9,571E-03 0,02815143 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 9,571E-03 0,02811548 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 9,571E-03 0,02807962 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 9,571E-03 0,02804385 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 9,571E-03 0,02800817 ! lamellipodium assembly GO:0030032 9 8 0,000 9,571E-03 0,02797258 ! regulation of embryonic development GO:0045995 16 8 0,000 9,571E-03 0,02793708 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 9,571E-03 0,02790167 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 9,571E-03 0,02786635 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 9,571E-03 0,02783112 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,01076177 0,03125261 ! regulation of developmental growth GO:0048638 13 9 0,000 0,01076177 0,0312132 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,01076177 0,03117389 ! telencephalon cell migration GO:0022029 16 9 0,000 0,01076177 0,03113468 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,01076177 0,03109556 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,01076177 0,03105655 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,01076177 0,03101763 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,01076177 0,03097881 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,01076177 0,03094009 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,01076177 0,03090146 ! GTP metabolic process GO:0046039 9 9 0,000 0,01076177 0,03086293 ! elastic fiber assembly GO:0048251 13 9 0,000 0,01076177 0,03082449 ! social behavior GO:0035176 14 9 0,000 0,01076177 0,03078616 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,01076177 0,03074791 ! artery development GO:0060840 19 9 0,000 0,01076177 0,03070976 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,01076177 0,03067171 ! regulation of glycolysis GO:0006110 15 9 0,000 0,01076177 0,03063375 ! response to pain GO:0048265 16 9 0,000 0,01076177 0,03059588 ! protein complex disassembly GO:0043241 17 9 0,000 0,01076177 0,03055811 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,01076177 0,03052043 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,01076177 0,03048284 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,01076177 0,03044535 ! lung alveolus development GO:0048286 17 9 0,000 0,01076177 0,03040795 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,01076177 0,03037064 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,01076177 0,03033342 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,01076177 0,03029629 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,01076177 0,03025925 ! ventral spinal cord development GO:0021517 11 9 0,000 0,01076177 0,03022231 ! protein targeting to ER GO:0045047 19 9 0,000 0,01076177 0,03018545 ! T cell selection GO:0045058 18 9 0,000 0,01076177 0,03014868 ! endoderm development GO:0007492 12 9 0,000 0,01076177 0,03011201 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,01076177 0,03007542 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,01076177 0,03003892 ! arginine catabolic process GO:0006527 10 9 0,000 0,01076177 0,03000251 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,01076177 0,02996619 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,01076177 0,02992995 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,01076177 0,0298938 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,01076177 0,02985774 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,01076177 0,02982177 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,01076177 0,02978588 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,01076177 0,02975008 ! mannose metabolic process GO:0006013 9 9 0,000 0,01076177 0,02971437 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,01076177 0,02967874 ! receptor clustering GO:0043113 15 9 0,000 0,01076177 0,0296432 ! epithelial cell development GO:0002064 10 9 0,000 0,01076177 0,02960774 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,01076177 0,02957236 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,01076177 0,02953708 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,01076177 0,02950187 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,01076177 0,02946675 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,01076177 0,02943171 ! motor axon guidance GO:0008045 14 9 0,000 0,01076177 0,02939676 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,01076177 0,02936189 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,01076177 0,0293271 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,01076177 0,02929239 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,01076177 0,02925777 ! blastoderm segmentation GO:0007350 11 9 0,000 0,01076177 0,02922322 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,01076177 0,02918876 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,01076177 0,02915438 ! response to amine stimulus GO:0014075 13 9 0,000 0,01076177 0,02912008 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,01076177 0,02908586 ! erythrocyte development GO:0048821 11 9 0,000 0,01076177 0,02905172 ! renal water homeostasis GO:0003091 14 9 0,000 0,01076177 0,02901767 ! postreplication repair GO:0006301 11 9 0,000 0,01076177 0,02898369 ! mRNA cleavage GO:0006379 13 9 0,000 0,01076177 0,02894979 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,01076177 0,02891597 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,01076177 0,02888223 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,01076177 0,02884857 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,01076177 0,02881498 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,01076177 0,02878148 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,01076177 0,02874805 ! acid secretion GO:0046717 14 9 0,000 0,01076177 0,0287147 ! musculoskeletal movement GO:0050881 11 9 0,000 0,01076177 0,02868142 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,01076177 0,02864823 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,01076177 0,02861511 ! oocyte differentiation GO:0009994 12 9 0,000 0,01076177 0,02858207 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,01076177 0,0285491 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,01076177 0,02851621 ! spleen development GO:0048536 15 9 0,000 0,01076177 0,02848339 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,01076177 0,02845065 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,01076177 0,02841799 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,01076177 0,0283854 ! detection of calcium ion GO:0005513 13 9 0,000 0,01076177 0,02835289 ! blastocyst formation GO:0001825 12 9 0,000 0,01076177 0,02832045 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,01076177 0,02828808 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,01076177 0,02825579 ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,01076177 0,02822357 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,01076177 0,02819142 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,01076177 0,02815935 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,01076177 0,02812735 ! prepulse inhibition GO:0060134 14 9 0,000 0,01076177 0,02809543 ! embryonic placenta development GO:0001892 12 9 0,000 0,01076177 0,02806357 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,01076177 0,02803179 ! insulin secretion GO:0030073 17 9 0,000 0,01076177 0,02800008 ! sequestering of metal ion GO:0051238 11 9 0,000 0,01076177 0,02796844 ! response to nicotine GO:0035094 16 9 0,000 0,01076177 0,02793687 ! establishment of cell polarity GO:0030010 12 9 0,000 0,01076177 0,02790538 ! nucleus localization GO:0051647 15 9 0,000 0,01076177 0,02787395 ! regulation of synapse organization GO:0050807 12 9 0,000 0,01076177 0,0278426 ! localization within membrane GO:0051668 15 9 0,000 0,01076177 0,02781131 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,01195069 0,03084914 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,01195069 0,03081456 ! neuron fate specification GO:0048665 11 10 0,000 0,01195069 0,03078005 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,01195069 0,03074562 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,01195069 0,03071127 ! thyroid gland development GO:0030878 19 10 0,000 0,01195069 0,03067699 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,01195069 0,03064279 ! synapsis GO:0007129 13 10 0,000 0,01195069 0,03060867 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,01195069 0,03057462 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,01195069 0,03054065 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,01195069 0,03050675 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,01195069 0,03047293 ! sulfate transport GO:0008272 12 10 0,000 0,01195069 0,03043919 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,01195069 0,03040552 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,01195069 0,03037192 ! androgen metabolic process GO:0008209 13 10 0,000 0,01195069 0,0303384 ! phospholipid efflux GO:0033700 16 10 0,000 0,01195069 0,03030495 ! hippocampus development GO:0021766 19 10 0,000 0,01195069 0,03027157 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,01195069 0,03023827 ! blood vessel remodeling GO:0001974 21 10 0,000 0,01195069 0,03020504 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,01195069 0,03017188 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,01195069 0,0301388 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,01195069 0,03010579 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,01195069 0,03007285 ! pathogenesis GO:0009405 13 10 0,000 0,01195069 0,03003998 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,01195069 0,03000719 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,01195069 0,02997447 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,01195069 0,02994181 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,01195069 0,02990923 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,01195069 0,02987672 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,01195069 0,02984428 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,01195069 0,02981192 ! melanocyte differentiation GO:0030318 15 10 0,000 0,01195069 0,02977962 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,01195069 0,02974739 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,01195069 0,02971523 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,01195069 0,02968314 ! response to X-ray GO:0010165 16 10 0,000 0,01195069 0,02965112 ! B cell proliferation GO:0042100 14 10 0,000 0,01195069 0,02961917 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,01195069 0,02958728 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,01195069 0,02955547 ! forebrain cell migration GO:0021885 17 10 0,000 0,01195069 0,02952372 ! lipid digestion GO:0044241 15 10 0,000 0,01195069 0,02949204 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,01195069 0,02946044 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,01195069 0,02942889 ! UV protection GO:0009650 14 10 0,000 0,01195069 0,02939742 ! entry into host cell GO:0030260 20 10 0,000 0,01195069 0,02936601 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,01195069 0,02933467 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,01195069 0,0293034 ! negative regulation of ossification GO:0030279 19 10 0,000 0,01195069 0,02927219 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,01195069 0,02924105 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,01195069 0,02920997 ! regulation of bone resorption GO:0045124 24 10 0,000 0,01195069 0,02917897 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,01195069 0,02914802 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,01195069 0,02911715 ! regulation of organ growth GO:0046620 11 10 0,000 0,01195069 0,02908633 ! response to dsRNA GO:0043331 18 10 0,000 0,01195069 0,02905559 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,01195069 0,02902491 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,01195069 0,02899429 ! embryonic axis specification GO:0000578 12 10 0,000 0,01195069 0,02896374 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,01195069 0,02893325 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,01195069 0,02890282 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,01195069 0,02887246 ! cranial nerve development GO:0021545 12 10 0,000 0,01195069 0,02884217 ! fucose catabolic process GO:0019317 16 10 0,000 0,01195069 0,02881193 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,01195069 0,02878177 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,01195069 0,02875166 ! protein sumoylation GO:0016925 12 10 0,000 0,01195069 0,02872162 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,01195069 0,02869163 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,01195069 0,02866172 ! zymogen activation GO:0031638 14 10 0,000 0,01195069 0,02863186 ! salivary gland development GO:0007431 22 10 0,000 0,01195069 0,02860207 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,01195069 0,02857233 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,01195069 0,02854266 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,01195069 0,02851306 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,01195069 0,02848351 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,01195069 0,02845402 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,01195069 0,0284246 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,01195069 0,02839523 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,01195069 0,02836593 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,01195069 0,02833669 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,01195069 0,0283075 ! detection of bacterium GO:0016045 10 10 0,000 0,01195069 0,02827838 ! embryonic gut development GO:0048566 11 10 0,000 0,01195069 0,02824932 ! activation of innate immune response GO:0002218 10 10 0,000 0,01195069 0,02822031 GO:0002758|innate immune response-activating signal transduction, ! cardiac cell differentiation GO:0035051 16 10 0,000 0,01195069 0,02819137 ! developmental induction GO:0031128 13 10 0,000 0,01195069 0,02816249 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,01195069 0,02813366 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,01195069 0,02810489 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,01195069 0,02807619 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,01195069 0,02804754 ! rRNA transcription GO:0009303 17 11 0,000 0,01313825 0,03080323 ! respiratory burst GO:0045730 14 11 0,000 0,01313825 0,03077187 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,01313825 0,03074056 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,01313825 0,03070932 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,01313825 0,03067814 ! virus-host interaction GO:0019048 17 11 0,000 0,01313825 0,03064703 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,01313825 0,03061598 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,01313825 0,03058499 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,01313825 0,03055407 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,01313825 0,0305232 ! RNA polyadenylation GO:0043631 19 11 0,000 0,01313825 0,0304924 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,01313825 0,03046167 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,01313825 0,03043099 ! mating GO:0007618 14 11 0,000 0,01313825 0,03040037 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,01313825 0,03036982 ! T cell proliferation GO:0042098 20 11 0,000 0,01313825 0,03033933 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,01313825 0,0303089 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,01313825 0,03027853 ! bone resorption GO:0045453 16 11 0,000 0,01313825 0,03024822 ! regulated secretory pathway GO:0045055 14 11 0,000 0,01313825 0,03021797 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,01313825 0,03018778 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,01313825 0,03015766 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,01313825 0,03012759 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,01313825 0,03009758 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,01313825 0,03006763 ! syncytium formation GO:0006949 15 11 0,000 0,01313825 0,03003775 ! plasma membrane organization GO:0007009 18 11 0,000 0,01313825 0,03000792 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,01313825 0,02997815 ! focal adhesion formation GO:0048041 24 11 0,000 0,01313825 0,02994844 ! mitotic spindle organization GO:0007052 15 11 0,000 0,01313825 0,02991878 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,01313825 0,02988919 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,01313825 0,02985966 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,01313825 0,02983018 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,01313825 0,02980076 ! adult heart development GO:0007512 11 11 0,000 0,01313825 0,0297714 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,01313825 0,0297421 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,01313825 0,02971285 ! temperature homeostasis GO:0001659 16 11 0,000 0,01313825 0,02968367 ! L-glutamate transport GO:0015813 16 11 0,000 0,01313825 0,02965454 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,01313825 0,02962546 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,01313825 0,02959645 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,01313825 0,02956749 ! stem cell development GO:0048864 29 11 0,000 0,01313825 0,02953858 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,01313825 0,02950974 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,01313825 0,02948095 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,01313825 0,02945221 ! vasoconstriction GO:0042310 15 11 0,000 0,01313825 0,02942354 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,01313825 0,02939491 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,01313825 0,02936635 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,01313825 0,02933784 ! ribosome assembly GO:0042255 13 11 0,000 0,01313825 0,02930938 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,01313825 0,02928098 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,01313825 0,02925264 ! chromatin silencing GO:0006342 19 11 0,000 0,01313825 0,02922434 ! nucleosome positioning GO:0016584 13 11 0,000 0,01313825 0,02919611 ! T cell homeostasis GO:0043029 20 11 0,000 0,01313825 0,02916793 ! regulation of isotype switching GO:0045191 19 11 0,000 0,01313825 0,0291398 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,01313825 0,02911173 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,01313825 0,02908371 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,01313825 0,02905574 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,01313825 0,02902783 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,01313825 0,02899997 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,01313825 0,02897217 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,01313825 0,02894442 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,01313825 0,02891672 ! male genitalia development GO:0030539 13 11 0,000 0,01313825 0,02888907 ! cholesterol efflux GO:0033344 19 11 0,000 0,01313825 0,02886148 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,01313825 0,02883394 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,01313825 0,02880646 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,01313825 0,02877902 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,01313825 0,02875164 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,01313825 0,02872431 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,01313825 0,02869703 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,01313825 0,0286698 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,01313825 0,02864263 ! lysogeny GO:0030069 18 11 0,000 0,01313825 0,0286155 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,01313825 0,02858843 ! acrosome reaction GO:0007340 13 11 0,000 0,01313825 0,02856141 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,01313825 0,02853444 ! lactation GO:0007595 20 12 0,000 0,01432445 0,03108135 ! reproductive cellular process GO:0048610 14 12 0,000 0,01432445 0,03105206 ! tRNA modification GO:0006400 14 12 0,000 0,01432445 0,03102282 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,01432445 0,03099363 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,01432445 0,0309645 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,01432445 0,03093543 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,01432445 0,03090641 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,01432445 0,03087744 ! non-recombinational repair GO:0000726 19 12 0,000 0,01432445 0,03084853 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,01432445 0,03081967 ! peroxisomal transport GO:0043574 21 12 0,000 0,01432445 0,03079087 ! cartilage condensation GO:0001502 18 12 0,000 0,01432445 0,03076212 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,01432445 0,03073343 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,01432445 0,03070478 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,01432445 0,03067619 ! heart looping GO:0001947 15 12 0,000 0,01432445 0,03064766 ! palate development GO:0060021 15 12 0,000 0,01432445 0,03061917 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,01432445 0,03059074 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,01432445 0,03056237 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,01432445 0,03053404 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,01432445 0,03050577 ! arginine metabolic process GO:0006525 13 12 0,000 0,01432445 0,03047755 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,01432445 0,03044938 ! methionine metabolic process GO:0006555 13 12 0,000 0,01432445 0,03042127 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,01432445 0,0303932 ! Golgi organization GO:0007030 18 12 0,000 0,01432445 0,03036519 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,01432445 0,03033723 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,01432445 0,03030932 ! monoamine transport GO:0015844 13 12 0,000 0,01432445 0,03028146 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,01432445 0,03025366 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,01432445 0,0302259 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,01432445 0,0301982 ! L-amino acid transport GO:0015807 20 12 0,000 0,01432445 0,03017054 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,01432445 0,03014294 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,01432445 0,03011539 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,01432445 0,03008788 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,01432445 0,03006043 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,01432445 0,03003303 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,01432445 0,03000568 ! cerebellum development GO:0021549 13 12 0,000 0,01432445 0,02997837 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,01432445 0,02995112 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,01432445 0,02992392 ! histone acetylation GO:0016573 23 12 0,000 0,01432445 0,02989676 ! histone methylation GO:0016571 15 12 0,000 0,01432445 0,02986966 ! autonomic nervous system development GO:0048483 23 12 0,000 0,01432445 0,0298426 ! gland morphogenesis GO:0022612 23 12 0,000 0,01432445 0,02981559 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,01432445 0,02978864 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,01432445 0,02976173 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,01432445 0,02973487 ! response to gamma radiation GO:0010332 20 12 0,000 0,01432445 0,02970805 ! regulation of epidermis development GO:0045682 17 12 0,000 0,01432445 0,02968129 ! intestinal absorption GO:0050892 19 12 0,000 0,01432445 0,02965457 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,01432445 0,02962791 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,01432445 0,02960129 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,01432445 0,02957471 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,01432445 0,02954819 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,01432445 0,02952171 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,01432445 0,02949528 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,01432445 0,0294689 ! microspike assembly GO:0030035 23 12 0,000 0,01432445 0,02944257 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,01432445 0,02941628 ! response to cold GO:0009409 14 12 0,000 0,01432445 0,02939004 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,01550929 0,03179266 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,01550929 0,03176435 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,01550929 0,03173609 ! cGMP metabolic process GO:0046068 16 13 0,000 0,01550929 0,03170788 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,01550929 0,03167972 ! water transport GO:0006833 17 13 0,000 0,01550929 0,03165161 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,01550929 0,03162355 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,01550929 0,03159554 ! lipid localization GO:0010876 24 13 0,000 0,01550929 0,03156758 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,01550929 0,03153967 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,01550929 0,03151181 ! organelle fusion GO:0048284 28 13 0,000 0,01550929 0,031484 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,01550929 0,03145623 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,01550929 0,03142852 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,01550929 0,03140085 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,01550929 0,03137323 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,01550929 0,03134567 ! response to hexose stimulus GO:0009746 19 13 0,000 0,01550929 0,03131815 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,01550929 0,03129067 ! glutamate metabolic process GO:0006536 18 13 0,000 0,01550929 0,03126325 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,01550929 0,03123587 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,01550929 0,03120855 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,01550929 0,03118127 ! NAD metabolic process GO:0019674 21 13 0,000 0,01550929 0,03115403 ! exocrine system development GO:0035272 27 13 0,000 0,01550929 0,03112685 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,01550929 0,03109971 ! bone mineralization GO:0030282 15 13 0,000 0,01550929 0,03107262 ! regulation of exocytosis GO:0017157 17 13 0,000 0,01550929 0,03104558 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,01550929 0,03101858 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,01550929 0,03099163 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,01550929 0,03096473 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,01550929 0,03093787 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,01550929 0,03091106 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,01550929 0,0308843 ! genitalia development GO:0048806 15 13 0,000 0,01550929 0,03085758 ! regulation of cellular pH GO:0030641 20 13 0,000 0,01550929 0,03083091 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,01550929 0,03080429 ! cellular pigmentation GO:0033059 24 13 0,000 0,01550929 0,03077771 ! tissue regeneration GO:0042246 21 13 0,000 0,01550929 0,03075118 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,01550929 0,03072469 ! cofactor transport GO:0051181 19 13 0,000 0,01550929 0,03069825 ! NADP metabolic process GO:0006739 18 13 0,000 0,01550929 0,03067186 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,01550929 0,03064551 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,01550929 0,0306192 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,01550929 0,03059294 ! gas transport GO:0015669 18 13 0,000 0,01550929 0,03056672 ! regulation of RNA stability GO:0043487 28 13 0,000 0,01550929 0,03054055 ! heme biosynthetic process GO:0006783 20 13 0,000 0,01550929 0,03051443 ! regulation of axon extension GO:0030516 23 13 0,000 0,01550929 0,03048835 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,01550929 0,03046231 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,01550929 0,03043632 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,01550929 0,03041037 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,01550929 0,03038447 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,01550929 0,03035861 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,01550929 0,0303328 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,01669278 0,0326197 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,01669278 0,03259201 ! superoxide anion generation GO:0042554 18 14 0,000 0,01669278 0,03256436 ! neuron maturation GO:0042551 21 14 0,000 0,01669278 0,03253677 ! regulation of S phase GO:0033261 18 14 0,000 0,01669278 0,03250922 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,01669278 0,03248171 ! myotube differentiation GO:0014902 21 14 0,000 0,01669278 0,03245426 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,01669278 0,03242684 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,01669278 0,03239948 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,01669278 0,03237216 ! inositol metabolic process GO:0006020 20 14 0,000 0,01669278 0,03234489 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,01669278 0,03231766 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,01669278 0,03229048 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,01669278 0,03226335 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,01669278 0,03223626 ! gene silencing by RNA GO:0031047 20 14 0,000 0,01669278 0,03220921 ! response to cAMP GO:0051591 19 14 0,000 0,01669278 0,03218222 ! limbic system development GO:0021761 25 14 0,000 0,01669278 0,03215526 ! startle response GO:0001964 21 14 0,000 0,01669278 0,03212835 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,01669278 0,03210149 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,01669278 0,03207467 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,01669278 0,0320479 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,01669278 0,03202117 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,01669278 0,03199449 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,01669278 0,03196785 ! glycine metabolic process GO:0006544 22 14 0,000 0,01669278 0,03194125 ! pituitary gland development GO:0021983 23 14 0,000 0,01669278 0,0319147 ! cellular response to starvation GO:0009267 21 14 0,000 0,01669278 0,03188819 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,01669278 0,03186173 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,01669278 0,03183531 ! regulation of heart rate GO:0002027 23 14 0,000 0,01669278 0,03180893 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,01669278 0,0317826 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,01669278 0,03175631 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,01669278 0,03173007 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,01669278 0,03170387 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,01669278 0,03167771 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,01669278 0,03165159 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,01669278 0,03162552 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,01669278 0,03159949 ! axon cargo transport GO:0008088 27 14 0,000 0,01669278 0,03157351 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,01669278 0,03154756 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,01669278 0,03152166 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,01669278 0,0314958 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,01669278 0,03146999 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,01669278 0,03144421 ! mRNA splice site selection GO:0006376 26 14 0,000 0,01669278 0,03141848 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,01669278 0,03139279 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,01669278 0,03136714 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,01669278 0,03134154 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,01669278 0,03131597 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,01669278 0,03129045 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,01669278 0,03126497 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,01669278 0,03123953 ! muscle maintenance GO:0046716 19 14 0,000 0,01669278 0,03121413 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,01669278 0,03118878 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,01669278 0,03116346 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,01669278 0,03113819 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,01669278 0,03111295 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,01669278 0,03108776 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,01669278 0,03106261 ! cilium assembly GO:0042384 20 14 0,000 0,01669278 0,0310375 ! peptide hormone secretion GO:0030072 23 14 0,000 0,01669278 0,03101243 ! positive regulation of cell size GO:0045793 20 15 0,000 0,01787491 0,03318183 ! metencephalon development GO:0022037 19 15 0,000 0,01787491 0,03315507 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,01787491 0,03312835 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,01787491 0,03310168 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,01787491 0,03307505 ! skin development GO:0043588 25 15 0,000 0,01787491 0,03304846 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,01787491 0,03302191 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,01787491 0,03299541 ! lipid phosphorylation GO:0046834 23 15 0,000 0,01787491 0,03296895 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,01787491 0,03294254 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,01787491 0,03291616 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,01787491 0,03288983 ! bile acid metabolic process GO:0008206 22 15 0,000 0,01787491 0,03286354 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,01787491 0,03283729 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,01787491 0,03281108 ! adult walking behavior GO:0007628 25 15 0,000 0,01787491 0,03278492 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,01787491 0,03275879 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,01787491 0,03273271 ! myoblast differentiation GO:0045445 27 15 0,000 0,01787491 0,03270667 ! centrosome cycle GO:0007098 16 15 0,000 0,01787491 0,03268067 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,01787491 0,03265471 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,01787491 0,0326288 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,01787491 0,03260292 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,01787491 0,03257709 ! cerebral cortex development GO:0021987 29 15 0,000 0,01787491 0,03255129 ! response to osmotic stress GO:0006970 22 15 0,000 0,01787491 0,03252554 ! vesicle coating GO:0006901 25 15 0,000 0,01787491 0,03249983 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,01787491 0,03247416 ! DNA integration GO:0015074 22 15 0,000 0,01787491 0,03244853 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,01787491 0,03242294 ! peptide secretion GO:0002790 27 15 0,000 0,01787491 0,03239739 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,01787491 0,03237188 ! regulation of vasodilation GO:0042312 24 15 0,000 0,01787491 0,03234641 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,01787491 0,03232098 ! neuron recognition GO:0008038 22 15 0,000 0,01787491 0,03229559 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,01787491 0,03227024 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,01787491 0,03224493 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,01787491 0,03221966 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,01787491 0,03219443 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,01787491 0,03216924 ! biomineral formation GO:0031214 18 15 0,000 0,01787491 0,03214408 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,01787491 0,03211897 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,01787491 0,0320939 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,01787491 0,03206886 ! dopamine metabolic process GO:0042417 30 15 0,000 0,01787491 0,03204387 ! organic cation transport GO:0015695 19 15 0,000 0,01787491 0,03201891 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,01787491 0,031994 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,01787491 0,03196912 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,01787491 0,03194428 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,01787491 0,03191948 ! defense response to virus GO:0051607 27 15 0,000 0,01787491 0,03189471 ! peptide hormone processing GO:0016486 19 15 0,000 0,01787491 0,03186999 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,01787491 0,0318453 ! protein secretion GO:0009306 27 16 0,000 0,01905568 0,03392266 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,01905568 0,03389642 ! hormone secretion GO:0046879 25 16 0,000 0,01905568 0,03387022 ! bone remodeling GO:0046849 24 16 0,000 0,01905568 0,03384407 ! endothelial cell migration GO:0043542 22 16 0,000 0,01905568 0,03381796 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,01905568 0,03379188 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,01905568 0,03376585 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,01905568 0,03373985 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,01905568 0,0337139 ! glial cell development GO:0021782 24 16 0,000 0,01905568 0,03368799 ! patterning of blood vessels GO:0001569 24 16 0,000 0,01905568 0,03366211 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,01905568 0,03363628 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,01905568 0,03361048 ! protein polyubiquitination GO:0000209 26 16 0,000 0,01905568 0,03358473 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,01905568 0,03355901 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,01905568 0,03353334 ! fructose metabolic process GO:0006000 20 16 0,000 0,01905568 0,0335077 ! regulation of protein binding GO:0043393 27 16 0,000 0,01905568 0,0334821 ! protein export from nucleus GO:0006611 24 16 0,000 0,01905568 0,03345654 ! negative regulation of immune response GO:0050777 28 16 0,000 0,01905568 0,03343102 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,01905568 0,03340554 ! DNA replication initiation GO:0006270 25 16 0,000 0,01905568 0,0333801 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,01905568 0,0333547 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,01905568 0,03332933 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,01905568 0,033304 ! diencephalon development GO:0021536 25 16 0,000 0,01905568 0,03327872 ! oogenesis GO:0048477 23 16 0,000 0,01905568 0,03325347 ! neural crest cell migration GO:0001755 24 16 0,000 0,01905568 0,03322826 ! G1 phase GO:0051318 27 16 0,000 0,01905568 0,03320308 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,01905568 0,03317795 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,01905568 0,03315285 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,01905568 0,03312779 ! steroid catabolic process GO:0006706 22 16 0,000 0,01905568 0,03310277 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,01905568 0,03307779 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,01905568 0,03305284 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,01905568 0,03302794 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,01905568 0,03300306 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,01905568 0,03297823 ! sperm-egg recognition GO:0035036 16 16 0,000 0,01905568 0,03295344 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,01905568 0,03292868 ! nerve development GO:0021675 18 16 0,000 0,01905568 0,03290396 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,01905568 0,03287927 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,01905568 0,03285463 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,02023511 0,03486198 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,02023511 0,03483589 ! negative regulation of defense response GO:0031348 19 17 0,000 0,02023511 0,03480983 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,02023511 0,03478382 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,02023511 0,03475784 ! glycerol metabolic process GO:0006071 20 17 0,000 0,02023511 0,0347319 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,02023511 0,034706 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,02023511 0,03468014 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,02023511 0,03465432 ! signal complex assembly GO:0007172 29 17 0,000 0,02023511 0,03462853 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,02023511 0,03460279 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,02023511 0,03457708 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,02023511 0,03455141 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,02023511 0,03452578 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,02023511 0,03450018 ! memory GO:0007613 25 17 0,000 0,02023511 0,03447463 ! keratinization GO:0031424 17 17 0,000 0,02023511 0,03444911 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,02023511 0,03442363 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,02023511 0,03439819 ! retinoid metabolic process GO:0001523 22 17 0,000 0,02023511 0,03437278 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,02023511 0,03434741 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,02023511 0,03432208 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,02023511 0,03429679 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,02023511 0,03427154 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,02023511 0,03424632 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,02023511 0,03422114 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,02023511 0,03419599 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,02023511 0,03417089 ! membrane budding GO:0006900 29 17 0,000 0,02023511 0,03414582 ! heme metabolic process GO:0042168 27 17 0,000 0,02023511 0,03412078 ! actin filament bundle formation GO:0051017 26 17 0,000 0,02023511 0,03409579 ! neuromuscular junction development GO:0007528 23 17 0,000 0,02023511 0,03407082 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,02023511 0,0340459 ! body fluid secretion GO:0007589 27 17 0,000 0,02023511 0,03402101 ! stem cell differentiation GO:0048863 36 17 0,000 0,02023511 0,03399616 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,02023511 0,03397135 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,02023511 0,03394657 ! sensory perception of pain GO:0019233 23 17 0,000 0,02023511 0,03392183 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,02023511 0,03389712 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,02023511 0,03387245 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,02023511 0,03384782 ! synaptogenesis GO:0007416 24 17 0,000 0,02023511 0,03382322 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,02023511 0,03379865 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,02023511 0,03377413 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,02023511 0,03374964 ! cell-cell junction organization GO:0045216 25 17 0,000 0,02023511 0,03372518 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,02023511 0,03370076 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,02023511 0,03367637 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,02023511 0,03365202 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,02023511 0,03362771 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,02023511 0,03360343 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,02023511 0,03357918 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,02141318 0,03550852 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,02141318 0,03548294 ! positive regulation of translation GO:0045727 28 18 0,000 0,02141318 0,03545739 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,02141318 0,03543188 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,02141318 0,03540641 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,02141318 0,03538097 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,02141318 0,03535558 ! cAMP metabolic process GO:0046058 33 18 0,000 0,02141318 0,03533021 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,02141318 0,03530489 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,02141318 0,0352796 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,02141318 0,03525434 ! axis specification GO:0009798 26 18 0,000 0,02141318 0,03522913 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,02141318 0,03520394 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,02141318 0,0351788 ! pancreas development GO:0031016 26 18 0,000 0,02141318 0,03515369 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,02141318 0,03512861 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,02141318 0,03510358 ! glutamine metabolic process GO:0006541 23 18 0,000 0,02141318 0,03507857 ! response to retinoic acid GO:0032526 25 18 0,000 0,02141318 0,03505361 ! pigmentation during development GO:0048066 31 18 0,000 0,02141318 0,03502868 ! central nervous system neuron development GO:0021954 30 18 0,000 0,02141318 0,03500378 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,02141318 0,03497892 ! fucose metabolic process GO:0006004 26 18 0,000 0,02141318 0,03495409 ! response to fungus GO:0009620 19 18 0,000 0,02141318 0,0349293 ! peptide cross-linking GO:0018149 31 18 0,000 0,02141318 0,03490455 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,02141318 0,03487983 ! heart process GO:0003015 27 18 0,000 0,02141318 0,03485514 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,02141318 0,03483049 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,02141318 0,03480588 ! visual learning GO:0008542 35 18 0,000 0,02141318 0,0347813 ! somitogenesis GO:0001756 24 18 0,000 0,02141318 0,03475675 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,02141318 0,03473224 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,02141318 0,03470776 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,02141318 0,03468332 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,02141318 0,03465891 ! vitamin transport GO:0051180 24 18 0,000 0,02141318 0,03463454 ! hormone transport GO:0009914 27 18 0,000 0,02141318 0,0346102 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,02141318 0,0345859 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,02141318 0,03456163 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,02141318 0,03453739 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,02141318 0,03451319 ! cell-cell recognition GO:0009988 20 18 0,000 0,02141318 0,03448902 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,02141318 0,03446488 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,02141318 0,03444078 ! regulation of glucose import GO:0046324 21 18 0,000 0,02141318 0,03441671 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,02141318 0,03439268 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,02141318 0,03436868 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,02141318 0,03434471 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,02141318 0,03432078 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,02258991 0,0361816 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,02258991 0,03615643 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,02258991 0,03613128 ! positive regulation of ossification GO:0045778 30 19 0,000 0,02258991 0,03610617 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,02258991 0,0360811 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,02258991 0,03605606 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,02258991 0,03603106 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,02258991 0,03600609 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,02258991 0,03598115 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,02258991 0,03595625 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,02258991 0,03593139 ! regeneration GO:0031099 32 19 0,000 0,02258991 0,03590655 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,02258991 0,03588176 ! response to alkaloid GO:0043279 32 19 0,000 0,02258991 0,03585699 ! sensory perception of taste GO:0050909 23 19 0,000 0,02258991 0,03583227 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,02258991 0,03580757 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,02258991 0,03578291 ! smooth muscle contraction GO:0006939 36 19 0,000 0,02258991 0,03575828 ! peroxisome organization GO:0007031 29 19 0,000 0,02258991 0,03573369 ! digestive system process GO:0022600 30 19 0,000 0,02258991 0,03570913 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,02258991 0,0356846 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,02258991 0,03566011 ! response to vitamin A GO:0033189 26 19 0,000 0,02258991 0,03563565 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,02258991 0,03561123 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,02258991 0,03558684 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,02258991 0,03556248 ! response to starvation GO:0042594 30 19 0,000 0,02258991 0,03553816 ! sex determination GO:0007530 29 19 0,000 0,02258991 0,03551386 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,02258991 0,03548961 ! plasma membrane fusion GO:0045026 23 19 0,000 0,02258991 0,03546538 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,02258991 0,03544119 ! cytolysis GO:0019835 20 19 0,000 0,02258991 0,03541703 ! renal system process GO:0003014 35 19 0,000 0,02258991 0,0353929 ! vasodilation GO:0042311 33 19 0,000 0,02258991 0,03536881 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,02258991 0,03534475 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,02258991 0,03532072 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,02258991 0,03529673 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,02258991 0,03527277 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,02258991 0,03524884 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,02258991 0,03522494 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,02258991 0,03520107 ! sarcomere organization GO:0045214 23 19 0,000 0,02258991 0,03517724 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,02258991 0,03515344 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,02258991 0,03512967 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,02258991 0,03510594 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,02258991 0,03508223 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,02258991 0,03505856 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,02258991 0,03503492 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,02258991 0,03501131 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,02258991 0,03498773 ! protein stabilization GO:0050821 26 19 0,000 0,02258991 0,03496419 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,02376528 0,03675868 ! iron ion transport GO:0006826 37 20 0,000 0,02376528 0,03673397 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,02376528 0,0367093 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,02376528 0,03668467 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,02376528 0,03666006 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,02376528 0,03663549 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,02376528 0,03661095 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,02376528 0,03658645 ! spinal cord development GO:0021510 31 20 0,000 0,02376528 0,03656197 ! response to ethanol GO:0045471 37 20 0,000 0,02376528 0,03653753 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,02376528 0,03651313 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,02376528 0,03648875 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,02376528 0,03646441 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,02376528 0,0364401 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,02376528 0,03641582 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,02376528 0,03639158 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,02376528 0,03636737 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,02376528 0,03634319 ! pallium development GO:0021543 38 20 0,000 0,02376528 0,03631904 ! DNA modification GO:0006304 28 20 0,000 0,02376528 0,03629492 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,02376528 0,03627084 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,02376528 0,03624679 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,02376528 0,03622276 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,02376528 0,03619878 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,02376528 0,03617482 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,02376528 0,03615089 ! collagen catabolic process GO:0030574 25 20 0,000 0,02376528 0,036127 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,02376528 0,03610314 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,02376528 0,03607931 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,02376528 0,03605551 ! alditol metabolic process GO:0019400 24 20 0,000 0,02376528 0,03603174 ! actin filament-based movement GO:0030048 34 20 0,000 0,02376528 0,03600801 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,02493931 0,03776196 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,02493931 0,03773712 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,02493931 0,03771231 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,02493931 0,03768753 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,02493931 0,03766279 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,02493931 0,03763807 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,02493931 0,03761339 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,02493931 0,03758874 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,02493931 0,03756413 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,02493931 0,03753954 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,02493931 0,03751499 ! protein amino acid acylation GO:0043543 37 21 0,000 0,02493931 0,03749047 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,02493931 0,03746599 ! vesicle docking GO:0048278 27 21 0,000 0,02493931 0,03744153 ! phototransduction GO:0007602 25 21 0,000 0,02493931 0,03741711 ! dendrite development GO:0016358 35 21 0,000 0,02493931 0,03739271 ! visual behavior GO:0007632 39 21 0,000 0,02493931 0,03736835 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,02493931 0,03734403 ! ovarian follicle development GO:0001541 30 21 0,000 0,02493931 0,03731973 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,02493931 0,03729546 ! autophagy GO:0006914 28 21 0,000 0,02493931 0,03727123 ! cell aging GO:0007569 32 21 0,000 0,02493931 0,03724703 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,02493931 0,03722286 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,02493931 0,03719872 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,02493931 0,03717461 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,02493931 0,03715053 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,02493931 0,03712649 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,02493931 0,03710247 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,02493931 0,03707849 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,02493931 0,03705454 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,02493931 0,03703062 ! fatty acid transport GO:0015908 30 21 0,000 0,02493931 0,03700672 ! immunoglobulin production GO:0002377 33 21 0,000 0,02493931 0,03698286 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,02493931 0,03695904 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,02493931 0,03693524 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,02493931 0,03691147 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,02493931 0,03688773 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,02493931 0,03686403 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,02493931 0,03684035 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,02493931 0,0368167 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,02493931 0,03679309 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,02493931 0,0367695 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,02493931 0,03674595 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,02493931 0,03672242 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,02493931 0,03669893 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,02493931 0,03667546 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,02493931 0,03665203 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,02493931 0,03662862 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,026112 0,03832648 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,026112 0,03830204 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,026112 0,03827763 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,026112 0,03825325 ! viral genome replication GO:0019079 29 22 0,000 0,026112 0,0382289 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,026112 0,03820458 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,026112 0,03818029 ! leukocyte adhesion GO:0007159 38 22 0,000 0,026112 0,03815604 ! molting cycle process GO:0022404 40 22 0,000 0,026112 0,03813181 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,026112 0,03810762 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,026112 0,03808345 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,026112 0,03805932 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,026112 0,03803521 ! vasculogenesis GO:0001570 33 22 0,000 0,026112 0,03801114 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,026112 0,0379871 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,026112 0,03796309 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,026112 0,0379391 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,026112 0,03791515 ! lysosome organization GO:0007040 37 22 0,000 0,026112 0,03789123 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,026112 0,03786734 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,026112 0,03784348 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,026112 0,03781965 ! regulation of behavior GO:0050795 38 22 0,000 0,026112 0,03779585 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,026112 0,03777208 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,026112 0,03774834 ! membrane depolarization GO:0051899 35 22 0,000 0,026112 0,03772462 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,026112 0,03770094 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,026112 0,03767729 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,026112 0,03765367 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,026112 0,03763008 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,026112 0,03760651 ! blastocyst development GO:0001824 37 22 0,000 0,026112 0,03758298 ! neural tube closure GO:0001843 33 22 0,000 0,026112 0,03755948 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,026112 0,037536 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,02728334 0,03919531 ! neuron fate commitment GO:0048663 32 23 0,000 0,02728334 0,03917084 ! embryonic pattern specification GO:0009880 31 23 0,000 0,02728334 0,03914641 ! myelination GO:0042552 35 23 0,000 0,02728334 0,039122 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,02728334 0,03909763 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,02728334 0,03907328 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,02728334 0,03904897 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,02728334 0,03902468 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,02728334 0,03900043 ! vesicle targeting GO:0006903 32 23 0,000 0,02728334 0,03897621 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,02728334 0,03895201 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,02728334 0,03892785 ! osteoblast differentiation GO:0001649 40 23 0,000 0,02728334 0,03890371 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,02728334 0,03887961 ! interaction with host GO:0051701 37 23 0,000 0,02728334 0,03885554 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,02728334 0,03883149 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,02728334 0,03880748 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,02728334 0,03878349 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,02728334 0,03875954 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,02728334 0,03873561 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,02728334 0,03871172 ! cell fate determination GO:0001709 45 23 0,000 0,02728334 0,03868785 ! pentose metabolic process GO:0019321 31 23 0,000 0,02728334 0,03866401 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,02728334 0,0386402 ! spermatid development GO:0007286 33 23 0,000 0,02728334 0,03861642 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,02728334 0,03859268 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,02728334 0,03856896 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,02728334 0,03854526 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,02728334 0,0385216 ! telomere organization GO:0032200 32 23 0,000 0,02728334 0,03849797 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,02728334 0,03847437 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,02728334 0,03845079 ! regulation of amine transport GO:0051952 38 23 0,000 0,02728334 0,03842724 ! liver development GO:0001889 40 23 0,000 0,02728334 0,03840373 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,02845334 0,04002611 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,02845334 0,04000165 ! initiation of viral infection GO:0019059 42 24 0,000 0,02845334 0,03997721 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,02845334 0,0399528 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,02845334 0,03992843 ! superoxide metabolic process GO:0006801 32 24 0,000 0,02845334 0,03990408 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,02845334 0,03987976 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,02845334 0,03985548 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,02845334 0,03983122 ! sperm motility GO:0030317 27 24 0,000 0,02845334 0,03980699 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,02845334 0,03978279 ! vacuole organization GO:0007033 39 24 0,000 0,02845334 0,03975862 ! receptor metabolic process GO:0043112 37 24 0,000 0,02845334 0,03973448 ! neural crest cell development GO:0014032 39 24 0,000 0,02845334 0,03971037 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,02845334 0,03968629 ! primary neural tube formation GO:0014020 35 24 0,000 0,02845334 0,03966224 ! negative regulation of cell development GO:0010721 56 24 0,000 0,02845334 0,03963821 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,02845334 0,03961422 ! base-excision repair GO:0006284 31 24 0,000 0,02845334 0,03959026 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,02845334 0,03956632 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,02845334 0,03954241 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,02845334 0,03951853 ! glutathione metabolic process GO:0006749 29 24 0,000 0,02845334 0,03949468 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,02845334 0,03947086 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,02845334 0,03944707 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,02845334 0,03942331 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,02962201 0,04101783 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,02962201 0,04099315 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,02962201 0,0409685 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,02962201 0,04094388 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,02962201 0,04091929 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,02962201 0,04089473 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,02962201 0,04087019 ! peptide transport GO:0015833 43 25 0,000 0,02962201 0,04084569 ! male gonad development GO:0008584 33 25 0,000 0,02962201 0,04082122 ! iron ion homeostasis GO:0055072 39 25 0,000 0,02962201 0,04079677 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,02962201 0,04077236 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,02962201 0,04074797 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,02962201 0,04072362 ! phospholipid transport GO:0015914 35 25 0,000 0,02962201 0,04069929 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,02962201 0,04067499 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,02962201 0,04065072 ! detection of light stimulus GO:0009583 30 25 0,000 0,02962201 0,04062648 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,02962201 0,04060227 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,02962201 0,04057809 ! leukocyte proliferation GO:0070661 39 25 0,000 0,02962201 0,04055394 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,02962201 0,04052981 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,03078933 0,04210193 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,03078933 0,04207692 ! translational initiation GO:0006413 43 26 0,000 0,03078933 0,04205193 ! regulation of pH GO:0006885 36 26 0,000 0,03078933 0,04202698 ! circadian rhythm GO:0007623 42 26 0,000 0,03078933 0,04200205 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,03078933 0,04197715 ! post-embryonic development GO:0009791 42 26 0,000 0,03078933 0,04195228 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,03078933 0,04192744 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,03078933 0,04190263 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,03078933 0,04187786 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,03078933 0,0418531 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,03078933 0,04182838 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,03078933 0,04180369 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,03078933 0,04177903 ! regulation of coagulation GO:0050818 39 26 0,000 0,03078933 0,04175439 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,03195531 0,04331009 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,03195531 0,04328458 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,03195531 0,0432591 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,03195531 0,04323366 ! membrane docking GO:0022406 39 27 0,000 0,03195531 0,04320824 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,03195531 0,04318285 ! catechol metabolic process GO:0009712 43 27 0,000 0,03195531 0,0431575 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,03195531 0,04313217 ! acute-phase response GO:0006953 42 27 0,000 0,03195531 0,04310687 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,03195531 0,0430816 ! myofibril assembly GO:0030239 36 27 0,000 0,03195531 0,04305637 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,03195531 0,04303116 ! response to ionizing radiation GO:0010212 47 27 0,000 0,03195531 0,04300598 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,03195531 0,04298083 ! natural killer cell activation GO:0030101 35 27 0,000 0,03195531 0,04295571 ! lipid oxidation GO:0034440 38 27 0,000 0,03195531 0,04293062 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,03195531 0,04290556 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,03195531 0,04288052 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,03195531 0,04285552 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,03195531 0,04283055 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,03195531 0,0428056 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,03195531 0,04278069 ! gene silencing GO:0016458 41 27 0,000 0,03195531 0,0427558 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,03311996 0,04428832 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,03311996 0,04426258 ! phenol metabolic process GO:0018958 44 28 0,000 0,03311996 0,04423688 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,03311996 0,04421121 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,03311996 0,04418556 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,03311996 0,04415995 ! cell junction assembly GO:0034329 56 28 0,000 0,03311996 0,04413436 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,03311996 0,04410881 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,03311996 0,04408328 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,03311996 0,04405778 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,03311996 0,04403232 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,03311996 0,04400688 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,03311996 0,04398147 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,03311996 0,04395609 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,03311996 0,04393074 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,03311996 0,04390542 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,03311996 0,04388013 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,03311996 0,04385487 ! mesoderm formation GO:0001707 46 28 0,000 0,03311996 0,04382964 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,03311996 0,04380443 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,03311996 0,04377926 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,03311996 0,04375411 ! ensheathment of neurons GO:0007272 43 28 0,000 0,03311996 0,04372899 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,03311996 0,04370391 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,03311996 0,04367885 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,03311996 0,04365382 ! neural tube formation GO:0001841 41 28 0,000 0,03311996 0,04362881 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,03311996 0,04360384 ! placenta development GO:0001890 37 28 0,000 0,03311996 0,0435789 ! regulation of B cell activation GO:0050864 42 28 0,000 0,03311996 0,04355398 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,03428327 0,04505802 ! regulation of innate immune response GO:0045088 38 29 0,000 0,03428327 0,04503228 ! ovulation cycle process GO:0022602 41 29 0,000 0,03428327 0,04500658 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,03428327 0,04498091 ! protein targeting to membrane GO:0006612 53 29 0,000 0,03428327 0,04495526 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,03428327 0,04492965 ! mismatch repair GO:0006298 34 29 0,000 0,03428327 0,04490406 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,03428327 0,0448785 ! muscle cell development GO:0055001 38 29 0,000 0,03428327 0,04485298 ! formation of primary germ layer GO:0001704 48 29 0,000 0,03428327 0,04482748 ! telencephalon development GO:0021537 52 29 0,000 0,03428327 0,04480201 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,03428327 0,04477656 ! eye morphogenesis GO:0048592 51 29 0,000 0,03428327 0,04475115 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,03428327 0,04472577 ! tissue homeostasis GO:0001894 42 29 0,000 0,03428327 0,04470041 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,03544525 0,04618928 ! collagen metabolic process GO:0032963 40 30 0,000 0,03544525 0,04616313 ! organic anion transport GO:0015711 51 30 0,000 0,03544525 0,046137 ! cholesterol transport GO:0030301 46 30 0,000 0,03544525 0,04611091 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,03544525 0,04608484 ! spliceosome assembly GO:0000245 49 30 0,000 0,03544525 0,04605881 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,03544525 0,0460328 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,03544525 0,04600682 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,03544525 0,04598087 ! ceramide metabolic process GO:0006672 43 30 0,000 0,03544525 0,04595495 ! ovulation cycle GO:0042698 43 30 0,000 0,03544525 0,04592906 ! hindbrain development GO:0030902 45 30 0,000 0,03544525 0,0459032 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,03544525 0,04587737 ! adult locomotory behavior GO:0008344 47 30 0,000 0,03544525 0,04585157 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,03544525 0,04582579 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,03544525 0,04580005 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,03544525 0,04577433 ! response to heat GO:0009408 41 30 0,000 0,03544525 0,04574865 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,03544525 0,04572299 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,03544525 0,04569736 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,0366059 0,04716727 ! negative regulation of secretion GO:0051048 49 31 0,000 0,0366059 0,04714086 ! mammary gland development GO:0030879 57 31 0,000 0,0366059 0,04711448 ! glial cell differentiation GO:0010001 55 31 0,000 0,0366059 0,04708813 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,0366059 0,04706181 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,0366059 0,04703552 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,0366059 0,04700926 ! odontogenesis GO:0042476 50 31 0,000 0,0366059 0,04698302 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,0366059 0,04695682 ! segmentation GO:0035282 41 31 0,000 0,0366059 0,04693065 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,0366059 0,0469045 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,0366059 0,04687839 ! metanephros development GO:0001656 58 31 0,000 0,0366059 0,0468523 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,0366059 0,04682624 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,0366059 0,04680021 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,0366059 0,04677421 ! cell fate specification GO:0001708 37 31 0,000 0,0366059 0,04674824 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,0366059 0,0467223 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,0366059 0,04669638 ! RNA modification GO:0009451 40 31 0,000 0,0366059 0,0466705 ! regulation of muscle development GO:0048634 48 32 0,000 0,03776522 0,04812189 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,03776522 0,04809525 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,03776522 0,04806863 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,03776522 0,04804204 ! meiosis I GO:0007127 52 32 0,000 0,03776522 0,04801549 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,03776522 0,04798896 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,03776522 0,04796246 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,03776522 0,04793599 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,03776522 0,04790955 ! peripheral nervous system development GO:0007422 53 32 0,000 0,03776522 0,04788314 ! regulation of protein stability GO:0031647 48 32 0,000 0,03776522 0,04785676 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,03776522 0,0478304 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,03776522 0,04780408 ! cytokine production GO:0001816 44 32 0,000 0,03776522 0,04777779 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,03776522 0,04775152 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,03776522 0,04772528 ! vesicle localization GO:0051648 47 32 0,000 0,03776522 0,04769907 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,03892321 0,04913468 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,03892321 0,04910773 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,03892321 0,04908081 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,03892321 0,04905391 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,03892321 0,04902705 ! sister chromatid segregation GO:0000819 46 33 0,000 0,03892321 0,04900021 ! ear morphogenesis GO:0042471 42 33 0,000 0,03892321 0,04897341 ! actomyosin structure organization GO:0031032 43 33 0,000 0,03892321 0,04894663 ! cell junction organization GO:0034330 63 33 0,000 0,03892321 0,04891989 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,03892321 0,04889317 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,03892321 0,04886648 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,03892321 0,04883982 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,03892321 0,04881319 ! female gonad development GO:0008585 49 33 0,000 0,03892321 0,04878659 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,03892321 0,04876002 ! positive regulation of cell development GO:0010720 54 33 0,000 0,03892321 0,04873347 ! lipid homeostasis GO:0055088 55 33 0,000 0,03892321 0,04870696 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,03892321 0,04868047 ! regulation of proteolysis GO:0030162 50 33 0,000 0,03892321 0,04865402 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,03892321 0,04862759 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,03892321 0,04860119 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,03892321 0,04857482 ! cytokinesis GO:0000910 52 33 0,000 0,03892321 0,04854848 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,03892321 0,04852216 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,04007988 0,04993701 ! mRNA catabolic process GO:0006402 48 34 0,000 0,04007988 0,04990997 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,04007988 0,04988296 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,04007988 0,04985598 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,04007988 0,04982904 ! feeding behavior GO:0007631 45 34 0,000 0,04007988 0,04980212 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,04007988 0,04977522 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,04007988 0,04974836 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,04007988 0,04972153 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,04007988 0,04969473 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,04007988 0,04966795 ! neuron migration GO:0001764 46 34 0,000 0,04007988 0,0496412 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,04007988 0,04961449 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,04007988 0,0495878 ! polyol metabolic process GO:0019751 44 34 0,000 0,04007988 0,04956114 ! aerobic respiration GO:0009060 47 34 0,000 0,04007988 0,04953451 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,04007988 0,0495079 ! embryonic organ development GO:0048568 45 34 0,000 0,04007988 0,04948133 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,04007988 0,04945478 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,04123521 0,05085308 ! Notch signaling pathway GO:0007219 56 35 0,000 0,04123521 0,05082583 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,04123521 0,0507986 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,04123521 0,05077141 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,04123521 0,05074424 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,04123521 0,05071711 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,04123521 0,05069 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,04123521 0,05066292 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,04123521 0,05063587 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,04123521 0,05060885 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,04123521 0,05058186 ! glycogen metabolic process GO:0005977 48 35 0,000 0,04123521 0,0505549 ! pigment metabolic process GO:0042440 61 35 0,000 0,04123521 0,05052797 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,04123521 0,05050106 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,04238923 0,05188676 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,04238923 0,05185916 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,04238923 0,05183159 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,04238923 0,05180405 ! negative regulation of binding GO:0051100 58 36 0,000 0,04238923 0,05177654 ! organic ether metabolic process GO:0018904 46 36 0,000 0,04238923 0,05174906 ! tissue remodeling GO:0048771 62 36 0,000 0,04238923 0,0517216 ! neural tube development GO:0021915 50 36 0,000 0,04238923 0,05169418 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,04238923 0,05166678 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,04238923 0,05163942 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,04238923 0,05161208 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,04238923 0,05158477 ! glucan metabolic process GO:0044042 49 36 0,000 0,04238923 0,05155749 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,04354192 0,0529315 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,04354192 0,05290354 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,04354192 0,05287561 ! learning GO:0007612 67 37 0,000 0,04354192 0,05284771 ! ion transmembrane transport GO:0034220 56 37 0,000 0,04354192 0,05281983 ! regulation of protein secretion GO:0050708 51 37 0,000 0,04354192 0,05279199 ! amino acid activation GO:0043038 52 37 0,000 0,04354192 0,05276418 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,04354192 0,05273639 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,04469328 0,0541024 ! gliogenesis GO:0042063 71 38 0,000 0,04469328 0,05407394 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,04469328 0,05404551 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,04469328 0,05401711 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,04469328 0,05398874 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,04469328 0,0539604 ! phagocytosis GO:0006909 60 38 0,000 0,04469328 0,05393209 ! mesenchymal cell development GO:0014031 64 38 0,000 0,04469328 0,0539038 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,04469328 0,05387555 ! maintenance of location in cell GO:0051651 69 38 0,000 0,04469328 0,05384733 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,04584333 0,05520401 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,04584333 0,05517513 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,04584333 0,05514627 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,04584333 0,05511744 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,04584333 0,05508864 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,04584333 0,05505988 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,04584333 0,05503114 ! male sex differentiation GO:0046661 53 39 0,000 0,04584333 0,05500243 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,04584333 0,05497376 ! chromatin remodeling GO:0006338 68 39 0,000 0,04584333 0,05494511 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,04584333 0,05491649 ! JNK cascade GO:0007254 54 39 0,000 0,04584333 0,0548879 ! developmental growth GO:0048589 62 39 0,000 0,04584333 0,05485935 ! cell growth GO:0016049 61 39 0,000 0,04584333 0,05483082 ! synapse organization GO:0050808 55 39 0,000 0,04584333 0,05480232 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,04699206 0,05614636 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,04699206 0,05611721 ! regulation of tube size GO:0035150 60 40 0,000 0,04699206 0,05608809 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,04699206 0,056059 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,04699206 0,05602993 ! peptide metabolic process GO:0006518 56 40 0,000 0,04699206 0,0560009 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,04699206 0,0559719 ! inner ear development GO:0048839 57 40 0,000 0,04699206 0,05594293 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,04699206 0,05591399 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,04699206 0,05588508 ! double-strand break repair GO:0006302 67 40 0,000 0,04699206 0,0558562 ! B cell differentiation GO:0030183 62 40 0,000 0,04699206 0,05582735 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,04699206 0,05579853 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,04699206 0,05576973 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,04699206 0,05574097 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,04699206 0,05571224 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,04813947 0,05704317 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,04813947 0,0570138 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,04813947 0,05698445 ! glucose transport GO:0015758 52 41 0,000 0,04813947 0,05695514 ! endosome transport GO:0016197 71 41 0,000 0,04813947 0,05692586 ! striated muscle contraction GO:0006941 62 41 0,000 0,04813947 0,0568966 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,04813947 0,05686738 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,04813947 0,05683819 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,04813947 0,05680903 ! biopolymer methylation GO:0043414 62 41 0,000 0,04813947 0,05677989 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,04813947 0,05675079 ! mitochondrial transport GO:0006839 60 42 0,000 0,04928557 0,05807214 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,04928557 0,0580424 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,04928557 0,0580127 ! cellular component disassembly GO:0022411 64 42 0,000 0,04928557 0,05798302 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,04928557 0,05795338 ! hexose transport GO:0008645 54 42 0,000 0,04928557 0,05792377 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,04928557 0,05789418 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,04928557 0,05786463 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,04928557 0,05783511 ! excretion GO:0007588 63 42 0,000 0,04928557 0,05780562 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,04928557 0,05777615 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,04928557 0,05774672 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,04928557 0,05771732 ! regulation of cell shape GO:0008360 78 42 0,000 0,04928557 0,05768795 ! positive regulation of binding GO:0051099 59 43 0,000 0,05043035 0,05899787 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,05043035 0,05896788 ! leukocyte migration GO:0050900 60 43 0,000 0,05043035 0,05893791 ! neuromuscular process GO:0050905 79 43 0,000 0,05043035 0,05890798 ! activation of caspase activity GO:0006919 65 43 0,000 0,05043035 0,05887808 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,05043035 0,05884821 ! tRNA processing GO:0008033 49 43 0,000 0,05043035 0,05881836 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,05043035 0,05878855 ! vesicle organization GO:0016050 79 43 0,000 0,05043035 0,05875877 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,05043035 0,05872902 ! methylation GO:0032259 64 43 0,000 0,05043035 0,0586993 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,05157382 0,0599999 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,05157382 0,05996956 ! glycolysis GO:0006096 53 44 0,000 0,05157382 0,05993926 ! regulation of action potential GO:0001508 71 44 0,000 0,05157382 0,05990899 ! regulation of ion transport GO:0043269 57 44 0,000 0,05157382 0,05987874 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,05157382 0,05984853 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,05157382 0,05981835 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,05157382 0,0597882 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,05157382 0,05975808 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,05157382 0,05972799 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,05157382 0,05969793 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,05157382 0,0596679 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,05157382 0,0596379 ! RNA catabolic process GO:0006401 64 45 0,000 0,05271598 0,06092802 ! positive regulation of defense response GO:0031349 59 45 0,000 0,05271598 0,06089742 ! regulation of translational initiation GO:0006446 64 45 0,000 0,05271598 0,06086685 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,05271598 0,0608363 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,05271598 0,0608058 ! cell recognition GO:0008037 58 45 0,000 0,05271598 0,06077532 ! cell maturation GO:0048469 60 45 0,000 0,05271598 0,06074487 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,05271598 0,06071445 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,05385683 0,06199735 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,05385683 0,06196634 ! cell redox homeostasis GO:0045454 63 46 0,000 0,05385683 0,06193535 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,05385683 0,0619044 ! regulation of ossification GO:0030278 71 46 0,000 0,05385683 0,06187348 ! histone modification GO:0016570 68 46 0,000 0,05385683 0,06184259 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,05385683 0,06181173 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,05499637 0,0630881 ! viral infectious cycle GO:0019058 71 47 0,000 0,05499637 0,06305665 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,05499637 0,06302523 ! endocrine system development GO:0035270 83 47 0,000 0,05499637 0,06299385 ! covalent chromatin modification GO:0016569 75 47 0,000 0,05499637 0,06296249 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,05499637 0,06293117 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,05499637 0,06289987 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,05499637 0,06286861 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,05499637 0,06283738 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,05499637 0,06280618 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,05499637 0,06277501 ! chloride transport GO:0006821 67 48 0,000 0,0561346 0,06404245 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,0561346 0,0640107 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,0561346 0,06397898 ! response to temperature stimulus GO:0009266 62 48 0,000 0,0561346 0,06394729 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,0561346 0,06391563 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,0561346 0,06388401 ! gastrulation GO:0007369 73 48 0,000 0,0561346 0,06385241 ! heart morphogenesis GO:0003007 65 48 0,000 0,0561346 0,06382085 ! regulation of DNA replication GO:0006275 75 48 0,000 0,0561346 0,06378932 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,0561346 0,06375782 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,0561346 0,06372635 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,0561346 0,06369491 ! regulation of endocytosis GO:0030100 63 48 0,000 0,0561346 0,0636635 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,0561346 0,06363212 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,0561346 0,06360078 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,05727153 0,06485697 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,05727153 0,06482505 ! sensory perception of smell GO:0007608 61 49 0,000 0,05727153 0,06479317 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,05727153 0,06476131 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,05727153 0,06472949 ! RNA elongation GO:0006354 62 49 0,000 0,05727153 0,0646977 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,05727153 0,06466594 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,05727153 0,06463421 ! germ cell development GO:0007281 68 49 0,000 0,05727153 0,06460251 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,05727153 0,06457084 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,05727153 0,0645392 ! cartilage development GO:0051216 70 49 0,000 0,05727153 0,0645076 ! maintenance of location GO:0051235 84 49 0,000 0,05727153 0,06447602 ! regulation of actin filament length GO:0030832 72 50 0,000 0,05840715 0,06572233 ! ear development GO:0043583 72 50 0,000 0,05840715 0,06569019 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,05840715 0,06565808 ! membrane fusion GO:0006944 80 50 0,000 0,05840715 0,06562601 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,05840715 0,06559397 ! lipid modification GO:0030258 73 50 0,000 0,05840715 0,06556195 ! positive regulation of growth GO:0045927 67 50 0,000 0,05840715 0,06552997 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,05840715 0,06549802 ! proton transport GO:0015992 75 50 0,000 0,05840715 0,0654661 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,05840715 0,06543421 ! positive regulation of secretion GO:0051047 71 51 0,000 0,05954147 0,06667253 ! hydrogen transport GO:0006818 77 51 0,000 0,05954147 0,06664009 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,05954147 0,06660767 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,05954147 0,06657529 ! positive regulation of cell migration GO:0030335 92 51 0,000 0,05954147 0,06654294 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,05954147 0,06651062 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,05954147 0,06647834 ! adult behavior GO:0030534 80 51 0,000 0,05954147 0,06644608 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,05954147 0,06641386 ! transition metal ion transport GO:0000041 74 52 0,000 0,06067448 0,06764485 ! regulation of cellular component size GO:0032535 74 52 0,000 0,06067448 0,06761207 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,06067448 0,06757933 ! aging GO:0007568 79 52 0,000 0,06067448 0,06754662 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,06067448 0,06751394 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,06067448 0,06748129 ! establishment of organelle localization GO:0051656 85 52 0,000 0,06067448 0,06744868 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,0618062 0,06867356 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,0618062 0,0686404 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,0618062 0,06860727 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,0618062 0,06857418 ! kidney development GO:0001822 90 53 0,000 0,0618062 0,06854111 ! single fertilization GO:0007338 59 53 0,000 0,0618062 0,06850808 ! cell projection assembly GO:0030031 76 53 0,000 0,0618062 0,06847508 ! amino acid transport GO:0006865 84 54 0,000 0,06293662 0,0696939 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,06293662 0,06966036 ! regulation of mitosis GO:0007088 84 54 0,000 0,06293662 0,06962685 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,06293662 0,06959338 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,06293662 0,06955994 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,06293662 0,06952653 ! DNA catabolic process GO:0006308 67 54 0,000 0,06293662 0,06949315 ! detection of external stimulus GO:0009581 66 54 0,000 0,06293662 0,0694598 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,06293662 0,06942649 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,06293662 0,06939321 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,06293662 0,06935996 ! exocytosis GO:0006887 74 55 0,000 0,06406574 0,0705705 ! mesoderm development GO:0007498 76 55 0,000 0,06406574 0,07053672 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,06406574 0,07050297 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,06519357 0,07170981 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,06519357 0,07167553 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,06519357 0,07164128 ! positive regulation of cell motion GO:0051272 99 56 0,000 0,06519357 0,07160707 ! negative regulation of protein kinase activity GO:0006469 99 57 0,000 0,0663201 0,07280966 ! carbohydrate transport GO:0008643 74 57 0,000 0,0663201 0,07277492 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,0663201 0,07274021 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,0663201 0,07270554 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,0663201 0,07267091 ! camera-type eye development GO:0043010 88 57 0,000 0,0663201 0,0726363 ! secondary metabolic process GO:0019748 84 57 0,000 0,0663201 0,07260173 ! developmental maturation GO:0021700 75 57 0,000 0,0663201 0,07256719 ! gonad development GO:0008406 79 57 0,000 0,0663201 0,07253268 ! negative regulation of kinase activity GO:0033673 100 58 0,000 0,06744534 0,07372827 ! viral reproductive process GO:0022415 87 58 0,000 0,06744534 0,07369324 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,06744534 0,07365825 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,06744534 0,07362329 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,06744534 0,07358837 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,06856928 0,07477921 ! activation of MAPK activity GO:0000187 84 59 0,000 0,06856928 0,07474377 ! lung development GO:0030324 94 59 0,000 0,06856928 0,07470836 ! actin filament organization GO:0007015 95 59 0,000 0,06856928 0,07467299 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,06856928 0,07463765 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,06856928 0,07460234 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,06969194 0,07578793 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,06969194 0,07575211 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,06969194 0,07571633 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,06969194 0,07568058 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,06969194 0,07564486 ! regulation of heart contraction GO:0008016 91 60 0,000 0,06969194 0,07560918 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,06969194 0,07557353 ! fertilization GO:0009566 68 60 0,000 0,06969194 0,07553792 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,06969194 0,07550234 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,07081331 0,07668108 ! meiosis GO:0007126 96 61 0,000 0,07081331 0,07664499 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,07081331 0,07660894 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,07081331 0,07657292 ! urogenital system development GO:0001655 101 61 0,000 0,07081331 0,07653694 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,07081331 0,07650099 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,07081331 0,07646508 ! extracellular matrix organization GO:0030198 103 61 0,000 0,07081331 0,07642919 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,07081331 0,07639334 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 0,000 0,07081331 0,07635753 ! amine catabolic process GO:0009310 90 62 0,000 0,07193339 0,07752896 ! neurotransmitter transport GO:0006836 81 62 0,000 0,07193339 0,07749264 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,07193339 0,07745637 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,07193339 0,07742012 ! respiratory tube development GO:0030323 99 62 0,000 0,07193339 0,07738391 ! meiotic cell cycle GO:0051321 97 62 0,000 0,07193339 0,07734773 ! organelle localization GO:0051640 96 62 0,000 0,07193339 0,07731159 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,07305218 0,07847736 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,07305218 0,07844072 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,07305218 0,07840412 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,07305218 0,07836755 ! viral reproduction GO:0016032 92 63 0,000 0,07305218 0,07833101 ! regulation of lipase activity GO:0060191 109 63 0,000 0,07305218 0,07829451 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,07416969 0,07945519 ! negative regulation of cell size GO:0045792 108 64 0,000 0,07416969 0,0794182 ! appendage morphogenesis GO:0035107 93 64 0,000 0,07416969 0,07938125 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,07416969 0,07934432 ! hexose catabolic process GO:0019320 82 64 0,000 0,07416969 0,07930744 ! respiratory system development GO:0060541 100 64 0,000 0,07416969 0,07927058 ! adaptive immune response GO:0002250 94 64 0,000 0,07416969 0,07923377 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,07528592 0,08038887 ! regulation of caspase activity GO:0043281 97 65 0,000 0,07528592 0,08035156 ! appendage development GO:0048736 94 65 0,000 0,07528592 0,08031429 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,07528592 0,08027706 ! defense response to bacterium GO:0042742 73 65 0,000 0,07528592 0,08023986 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,07528592 0,08020269 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,07528592 0,08016556 ! activation of immune response GO:0002253 83 65 0,000 0,07528592 0,08012847 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,07640087 0,08127752 ! antigen processing and presentation GO:0019882 96 66 0,000 0,07640087 0,08123994 ! axon guidance GO:0007411 99 66 0,000 0,07640087 0,0812024 ! regulation of immune effector process GO:0002697 101 66 0,000 0,07640087 0,08116489 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,07751453 0,08230998 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,07751453 0,082272 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,07751453 0,08223405 ! acute inflammatory response GO:0002526 92 68 0,000 0,07862692 0,08337571 ! learning or memory GO:0007611 123 68 0,000 0,07862692 0,08333728 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,07862692 0,0832989 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,07862692 0,08326055 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,07862692 0,08322223 ! rhythmic process GO:0048511 105 68 0,000 0,07862692 0,08318395 ! inorganic anion transport GO:0015698 93 68 0,000 0,07862692 0,0831457 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,07973802 0,08428192 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,07973802 0,0842432 ! response to drug GO:0042493 108 69 0,000 0,07973802 0,08420452 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,08084786 0,08533734 ! humoral immune response GO:0006959 86 70 0,000 0,08084786 0,0852982 ! eye development GO:0001654 111 70 0,000 0,08084786 0,08525909 ! amine transport GO:0015837 101 70 0,000 0,08084786 0,08522001 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,08084786 0,08518097 ! regulation of catabolic process GO:0009894 106 70 0,000 0,08084786 0,08514197 ! muscle cell differentiation GO:0042692 104 71 0,000 0,08195641 0,08626991 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,08195641 0,08623044 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,08195641 0,08619101 ! regulation of peptidase activity GO:0052547 106 72 0,000 0,0830637 0,08731559 ! response to hypoxia GO:0001666 132 72 0,000 0,0830637 0,0872757 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,0830637 0,08723585 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,0830637 0,08719603 ! negative regulation of transport GO:0051051 116 73 0,000 0,08416971 0,08831676 ! regulation of blood pressure GO:0008217 107 73 0,000 0,08416971 0,08827648 ! tube morphogenesis GO:0035239 118 73 0,000 0,08416971 0,08823625 ! mitochondrion organization GO:0007005 104 73 0,000 0,08416971 0,08819605 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,08416971 0,08815589 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,08416971 0,08811576 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,08527445 0,08923168 ! response to oxygen levels GO:0070482 137 74 0,000 0,08527445 0,0891911 ! digestion GO:0007586 97 74 0,000 0,08527445 0,08915056 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,08527445 0,08911006 ! blood coagulation GO:0007596 116 75 0,000 0,08637792 0,09022217 GO:0050817|coagulation, ! negative regulation of growth GO:0045926 123 75 0,000 0,08637792 0,09018122 ! response to nutrient GO:0007584 104 75 0,000 0,08637792 0,0901403 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,08637792 0,09009942 ! amine biosynthetic process GO:0009309 97 76 0,000 0,08748012 0,09120775 ! tRNA metabolic process GO:0006399 95 76 0,000 0,08748012 0,09116642 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,08748012 0,09112513 ! regulation of protein transport GO:0051223 114 76 0,000 0,08748012 0,09108388 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,08858106 0,09218844 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,08858106 0,09214674 ! regulation of DNA binding GO:0051101 119 77 0,000 0,08858106 0,09210508 ! gland development GO:0048732 148 77 0,000 0,08858106 0,09206346 ! sex differentiation GO:0007548 105 77 0,000 0,08858106 0,09202188 ! protein ubiquitination GO:0016567 125 77 0,000 0,08858106 0,09198034 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,08858106 0,09193883 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,08858106 0,09189736 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,08858106 0,09185593 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,08968073 0,09295434 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,08968073 0,09291247 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,09077914 0,09400812 ! cellular respiration GO:0045333 107 79 0,000 0,09077914 0,09396581 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,09077914 0,09392354 ! regulation of lyase activity GO:0051339 133 79 0,000 0,09077914 0,09388131 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,09077914 0,09383911 ! chromatin assembly GO:0031497 102 80 0,000 0,09187629 0,09493058 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,09187629 0,09488795 ! forebrain development GO:0030900 131 80 0,000 0,09187629 0,09484536 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,09297217 0,0959336 ! hemostasis GO:0007599 125 81 0,000 0,09297217 0,09589058 ! mRNA transport GO:0051028 121 81 0,000 0,09297217 0,0958476 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,09297217 0,09580466 ! regulation of neurological system process GO:0031644 122 81 0,000 0,09297217 0,09576176 ! vitamin metabolic process GO:0006766 103 81 0,000 0,09297217 0,09571889 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,09297217 0,09567606 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,0940668 0,09675923 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,0940668 0,09671598 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,09516017 0,09779642 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,09516017 0,09775274 ! regulation of defense response GO:0031347 117 84 0,000 0,09625228 0,09883047 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,09625228 0,09878636 ! sterol metabolic process GO:0016125 120 84 0,000 0,09625228 0,0987423 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,09734313 0,09981686 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,09734313 0,09977237 ! rRNA metabolic process GO:0016072 107 85 0,000 0,09734313 0,09972793 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 0,000 0,09734313 0,09968353 ! transcription initiation GO:0006352 118 85 0,000 0,09734313 0,09963917 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,09734313 0,09959484 ! regulation of protein localization GO:0032880 132 85 0,000 0,09734313 0,09955056 ! regulation of membrane potential GO:0042391 128 85 0,000 0,09734313 0,09950632 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,09734313 0,09946211 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,09843274 0,10053077 ! cell cycle arrest GO:0007050 150 86 0,000 0,09843274 0,10048615 ! nucleosome organization GO:0034728 114 87 0,000 0,09952108 0,10155213 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,09952108 0,10150709 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,09952108 0,1014621 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,09952108 0,10141714 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,09952108 0,10137223 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,09952108 0,10132735 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,10060818 0,10238886 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,10060818 0,10234357 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,10060818 0,10229833 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,10060818 0,10225312 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,10169403 0,10331107 ! reproductive developmental process GO:0003006 127 89 0,000 0,10169403 0,10326546 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,10169403 0,10321989 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,10169403 0,10317436 ! regulation of T cell activation GO:0050863 128 89 0,000 0,10169403 0,10312887 ! leukocyte differentiation GO:0002521 143 90 0,000 0,10277863 0,10418283 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,10277863 0,10413694 ! hormone metabolic process GO:0042445 121 90 0,000 0,10277863 0,10409108 ! ATP metabolic process GO:0046034 137 91 0,000 0,10386198 0,10514197 ! response to virus GO:0009615 122 91 0,000 0,10386198 0,10509571 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,10494408 0,10614397 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,10494408 0,10609732 ! cell fate commitment GO:0045165 141 92 0,000 0,10494408 0,1060507 ! positive regulation of immune response GO:0050778 121 92 0,000 0,10494408 0,10600413 ! DNA recombination GO:0006310 146 92 0,000 0,10494408 0,10595759 ! sulfur metabolic process GO:0006790 118 92 0,000 0,10494408 0,1059111 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,10602495 0,10695499 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,10602495 0,1069081 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,10602495 0,10686125 ! electron transport chain GO:0022900 123 94 0,000 0,10710456 0,1079021 ! response to oxidative stress GO:0006979 141 94 0,000 0,10710456 0,10785486 ! regulation of binding GO:0051098 151 95 0,000 0,10818294 0,10889311 ! angiogenesis GO:0001525 149 95 0,000 0,10818294 0,10884548 ! carboxylic acid transport GO:0046942 147 95 0,000 0,10818294 0,10879788 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,10926008 0,10983312 ! in utero embryonic development GO:0001701 147 96 0,000 0,10926008 0,10978514 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,10926008 0,10973719 ! protein maturation GO:0051604 129 96 0,000 0,10926008 0,10968929 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,11033597 0,11072109 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,11033597 0,1106728 ! calcium ion transport GO:0006816 167 99 0,000 0,11248405 0,11277826 ! extracellular structure organization GO:0043062 156 99 0,000 0,11248405 0,11272912 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,11355624 0,11375407 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,11355624 0,11370455 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,11355624 0,11365507 ! divalent metal ion transport GO:0070838 171 100 0,000 0,11355624 0,11360563 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,11355624 0,11355624