pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a1/out-0.05-06-0.01-300-run-a1//th1-pval-1e-02-02-th2-pval-1e-01-11-th3-pval-1e-01-01-run-a1/go_data/23512-2-real-Loi_GPL570-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 6,416E-14 1,567E-10 ! response to UV GO:0009411 120 55 4,000 2,185E-11 2,668E-08 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 3,000 3,315E-09 2,7E-06 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 2,000 3,4E-09 2,077E-06 ! phosphoinositide-mediated signaling GO:0048015 141 75 3,000 2,452E-08 1,198E-05 ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 6,901E-08 2,81E-05 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 7,245E-08 2,528E-05 ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 8,536E-07 2,607E-04 ! positive regulation of cell cycle GO:0045787 96 48 2,000 1,04E-06 2,822E-04 ! positive regulation of growth GO:0045927 96 53 2,000 1,406E-06 3,436E-04 ! anagen GO:0042640 7 5 1,000 1,661E-06 3,689E-04 ! response to food GO:0032094 6 5 1,000 1,661E-06 3,382E-04 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 1,000 1,661E-06 3,121E-04 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 2,491E-06 4,347E-04 ! hair follicle maturation GO:0048820 8 6 1,000 2,491E-06 4,057E-04 ! negative regulation of cell size GO:0045792 144 69 2,000 3,133E-06 4,783E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 2,000 3,133E-06 4,502E-04 ! negative regulation of kinase activity GO:0033673 145 70 2,000 3,272E-06 4,441E-04 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 3,486E-06 4,483E-04 ! histone ubiquitination GO:0016574 9 7 1,000 3,486E-06 4,259E-04 ! negative regulation of transferase activity GO:0051348 155 74 2,000 3,871E-06 4,503E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 5,974E-06 6,634E-04 ! mitochondrion organization GO:0007005 159 87 2,000 6,309E-06 6,701E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 7,466E-06 7,599E-04 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 7,466E-06 7,295E-04 ! glucan biosynthetic process GO:0009250 14 10 1,000 7,466E-06 7,015E-04 GO:0005978|glycogen biosynthetic process, ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 9,122E-06 8,254E-04 ! keratinocyte proliferation GO:0043616 19 11 1,000 9,122E-06 7,959E-04 ! UV protection GO:0009650 20 11 1,000 9,122E-06 7,685E-04 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 1,094E-05 8,912E-04 ! regulation of B cell proliferation GO:0030888 22 12 1,000 1,094E-05 8,625E-04 ! T cell homeostasis GO:0043029 28 12 1,000 1,094E-05 8,355E-04 ! positive regulation of cell growth GO:0030307 24 13 1,000 1,293E-05 9,573E-04 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 1,293E-05 9,291E-04 ! histone methylation GO:0016571 29 13 1,000 1,293E-05 9,026E-04 ! negative regulation of caspase activity GO:0043154 23 14 1,000 1,508E-05 1,024E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 1,508E-05 9,958E-04 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 1,74E-05 1,119E-03 ! lymphocyte homeostasis GO:0002260 33 15 1,000 1,74E-05 1,09E-03 ! positive regulation of cell size GO:0045793 29 16 1,000 1,988E-05 1,214E-03 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 1,000 1,988E-05 1,185E-03 ! negative regulation of peptidase activity GO:0010466 28 17 1,000 2,252E-05 1,31E-03 ! regulation of survival gene product expression GO:0045884 38 17 1,000 2,252E-05 1,28E-03 ! positive regulation of proteolysis GO:0045862 36 18 1,000 2,533E-05 1,407E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 2,533E-05 1,375E-03 ! skin development GO:0043588 42 20 1,000 3,144E-05 1,67E-03 ! cellular response to unfolded protein GO:0034620 35 20 1,000 3,144E-05 1,634E-03 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 3,144E-05 1,6E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 3,475E-05 1,732E-03 ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 3,821E-05 1,867E-03 ! peptidyl-serine modification GO:0018209 50 22 1,000 3,821E-05 1,83E-03 ! positive regulation of B cell activation GO:0050871 42 22 1,000 3,821E-05 1,795E-03 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 4,184E-05 1,929E-03 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 4,563E-05 2,064E-03 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 4,563E-05 2,027E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 4,563E-05 1,991E-03 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 4,959E-05 2,125E-03 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 4,959E-05 2,089E-03 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 4,959E-05 2,053E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 4,959E-05 2,019E-03 ! leukocyte homeostasis GO:0001776 50 25 1,000 4,959E-05 1,986E-03 ! molting cycle process GO:0022404 52 26 1,000 5,371E-05 2,116E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! protein amino acid alkylation GO:0008213 59 26 1,000 5,371E-05 2,083E-03 GO:0006479|protein amino acid methylation, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 5,371E-05 2,05E-03 GO:0045936|negative regulation of phosphate metabolic process, ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 5,371E-05 2,019E-03 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 1,000 5,799E-05 2,147E-03 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 5,799E-05 2,114E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 6,244E-05 2,243E-03 ! fat cell differentiation GO:0045444 57 28 1,000 6,244E-05 2,211E-03 ! base-excision repair GO:0006284 41 28 1,000 6,244E-05 2,179E-03 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 6,704E-05 2,307E-03 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 7,182E-05 2,437E-03 ! regulation of B cell activation GO:0050864 55 30 1,000 7,182E-05 2,403E-03 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 7,675E-05 2,534E-03 ! response to heat GO:0009408 54 31 1,000 7,675E-05 2,5E-03 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 1,000 8,185E-05 2,631E-03 ! spindle organization GO:0007051 50 32 1,000 8,185E-05 2,597E-03 ! positive regulation of catabolic process GO:0009896 72 32 1,000 8,185E-05 2,563E-03 ! placenta development GO:0001890 53 35 1,000 9,811E-05 3,034E-03 ! regulation of proteolysis GO:0030162 77 36 1,000 1,039E-04 3,172E-03 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 1,039E-04 3,132E-03 ! meiosis I GO:0007127 74 38 1,000 1,158E-04 3,451E-03 ! glycogen metabolic process GO:0005977 63 38 1,000 1,158E-04 3,409E-03 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 1,158E-04 3,369E-03 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 1,221E-04 3,508E-03 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 1,000 1,221E-04 3,468E-03 GO:0006073|cellular glucan metabolic process, ! glucose transport GO:0015758 66 43 1,000 1,486E-04 4,173E-03 ! energy reserve metabolic process GO:0006112 76 44 1,000 1,556E-04 4,321E-03 ! hexose transport GO:0008645 68 44 1,000 1,556E-04 4,272E-03 GO:0015749|monosaccharide transport, ! double-strand break repair GO:0006302 85 44 1,000 1,556E-04 4,225E-03 ! keratinocyte differentiation GO:0030216 81 45 1,000 1,628E-04 4,372E-03 ! biopolymer methylation GO:0043414 91 45 1,000 1,628E-04 4,324E-03 ! developmental growth GO:0048589 88 45 1,000 1,628E-04 4,278E-03 ! polysaccharide biosynthetic process GO:0000271 79 46 1,000 1,702E-04 4,424E-03 ! response to insulin stimulus GO:0032868 98 47 1,000 1,777E-04 4,57E-03 ! methylation GO:0032259 97 48 1,000 1,854E-04 4,718E-03 ! response to calcium ion GO:0051592 94 49 1,000 1,933E-04 4,867E-03 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 1,933E-04 4,818E-03 ! epidermal cell differentiation GO:0009913 87 50 1,000 2,013E-04 4,966E-03 ! response to temperature stimulus GO:0009266 84 51 1,000 2,094E-04 5,116E-03 ! histone modification GO:0016570 104 52 1,000 2,177E-04 5,267E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 2,262E-04 5,418E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! covalent chromatin modification GO:0016569 115 54 1,000 2,349E-04 5,571E-03 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 2,437E-04 5,724E-03 ! regulation of protein catabolic process GO:0042176 126 56 1,000 2,526E-04 5,878E-03 ! regulation of DNA replication GO:0006275 105 56 1,000 2,526E-04 5,823E-03 ! nucleotide-excision repair GO:0006289 91 57 1,000 2,618E-04 5,977E-03 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 2,71E-04 6,131E-03 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 3,098E-04 6,943E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 1,000 3,301E-04 7,331E-03 ! response to peptide hormone stimulus GO:0043434 129 64 1,000 3,301E-04 7,265E-03 ! negative regulation of cell growth GO:0030308 142 67 1,000 3,617E-04 7,891E-03 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 3,726E-04 8,056E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 3,836E-04 8,222E-03 ! homeostasis of number of cells GO:0048872 131 69 1,000 3,836E-04 8,15E-03 ! developmental maturation GO:0021700 128 69 1,000 3,836E-04 8,08E-03 ! germ cell development GO:0007281 133 70 1,000 3,948E-04 8,244E-03 ! carbohydrate transport GO:0008643 114 72 1,000 4,177E-04 8,647E-03 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 4,177E-04 8,575E-03 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 1,000 4,177E-04 8,503E-03 ! regulation of caspase activity GO:0043281 136 74 1,000 4,412E-04 8,907E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 4,412E-04 8,834E-03 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 4,776E-04 9,485E-03 ! positive regulation of ligase activity GO:0051351 130 77 1,000 4,776E-04 9,409E-03 ! regulation of catabolic process GO:0009894 173 77 1,000 4,776E-04 9,334E-03 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 4,9E-04 9,501E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 5,026E-04 9,668E-03 ! meiosis GO:0007126 143 81 1,000 5,283E-04 0,01008308 GO:0051327|M phase of meiotic cell cycle, ! positive regulation of phosphorylation GO:0042327 149 81 1,000 5,283E-04 0,01000492 ! regulation of peptidase activity GO:0052547 150 82 1,000 5,414E-04 0,01017368 ! protein import into nucleus GO:0006606 174 82 1,000 5,414E-04 0,01009602 ! meiotic cell cycle GO:0051321 144 82 1,000 5,414E-04 0,01001953 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 5,546E-04 0,01018725 GO:0045937|positive regulation of phosphate metabolic process, ! nuclear import GO:0051170 177 83 1,000 5,546E-04 0,01011123 ! response to metal ion GO:0010038 158 84 1,000 5,68E-04 0,01027861 ! regulation of ligase activity GO:0051340 147 84 1,000 5,68E-04 0,01020303 ! negative regulation of growth GO:0045926 168 85 1,000 5,815E-04 0,01037009 ! cellular response to hormone stimulus GO:0032870 182 85 1,000 5,815E-04 0,01029495 ! positive regulation of cell activation GO:0050867 161 86 1,000 5,952E-04 0,01046169 GO:0002696|positive regulation of leukocyte activation, ! one-carbon metabolic process GO:0006730 167 88 1,000 6,231E-04 0,0108733 ! protein localization in nucleus GO:0034504 192 89 1,000 6,373E-04 0,01104168 ! response to inorganic substance GO:0010035 173 90 1,000 6,516E-04 0,01121037 ! positive regulation of protein modification process GO:0031401 156 90 1,000 6,516E-04 0,01113198 ! response to unfolded protein GO:0006986 139 90 1,000 6,516E-04 0,01105467 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 6,955E-04 0,01171821 GO:0010498|proteasomal protein catabolic process, ! carbohydrate biosynthetic process GO:0016051 158 94 1,000 7,105E-04 0,01188805 ! response to protein stimulus GO:0051789 158 96 1,000 7,408E-04 0,01231171 ! regulation of DNA metabolic process GO:0051052 188 97 1,000 7,562E-04 0,01248293 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 2,108E-03 0,03456926 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 2,108E-03 0,03433879 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 2,108E-03 0,03411138 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 2,108E-03 0,03388697 ! positive regulation of helicase activity GO:0051096 12 5 0,000 2,108E-03 0,03366548 ! neuron fate determination GO:0048664 7 5 0,000 2,108E-03 0,03344688 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 2,108E-03 0,03323109 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 2,108E-03 0,03301807 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 2,108E-03 0,03280776 ! polyol transport GO:0015791 12 5 0,000 2,108E-03 0,03260012 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 2,108E-03 0,03239509 ! response to superoxide GO:0000303 10 5 0,000 2,108E-03 0,03219262 ! negative regulation of bone resorption GO:0045779 10 5 0,000 2,108E-03 0,03199266 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 2,108E-03 0,03179518 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 2,108E-03 0,03160012 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 2,108E-03 0,03140743 ! female meiosis GO:0007143 10 5 0,000 2,108E-03 0,03121709 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 2,108E-03 0,03102903 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 2,108E-03 0,03084323 ! hypothalamus development GO:0021854 9 5 0,000 2,108E-03 0,03065964 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 2,108E-03 0,03047822 ! cobalt ion transport GO:0006824 11 5 0,000 2,108E-03 0,03029894 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 2,108E-03 0,03012175 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 2,108E-03 0,02994662 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 2,108E-03 0,02977352 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 2,108E-03 0,02960241 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 2,108E-03 0,02943325 ! embryonic camera-type eye development GO:0031076 12 5 0,000 2,108E-03 0,02926602 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 2,108E-03 0,02910067 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 2,108E-03 0,02893719 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 2,108E-03 0,02877553 ! transposition GO:0032196 9 5 0,000 2,108E-03 0,02861566 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 2,108E-03 0,02845756 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 2,108E-03 0,0283012 ! negative chemotaxis GO:0050919 16 5 0,000 2,108E-03 0,02814655 ! positive regulation of histone modification GO:0031058 6 5 0,000 2,108E-03 0,02799358 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 2,108E-03 0,02784227 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 2,108E-03 0,02769258 ! behavioral response to pain GO:0048266 10 5 0,000 2,108E-03 0,02754449 ! clathrin coat assembly GO:0048268 15 5 0,000 2,108E-03 0,02739797 ! Notch receptor processing GO:0007220 11 5 0,000 2,108E-03 0,02725301 ! regulation of dopamine uptake GO:0051584 9 5 0,000 2,108E-03 0,02710957 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 2,108E-03 0,02696764 ! micturition GO:0060073 9 5 0,000 2,108E-03 0,02682718 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 2,108E-03 0,02668818 ! copulation GO:0007620 9 5 0,000 2,108E-03 0,02655061 ! glial cell fate commitment GO:0021781 14 5 0,000 2,108E-03 0,02641446 ! protein maturation by protein folding GO:0022417 14 5 0,000 2,108E-03 0,02627969 ! bioluminescence GO:0008218 9 5 0,000 2,108E-03 0,02614629 ! spermidine metabolic process GO:0008216 7 5 0,000 2,108E-03 0,02601424 ! regulation of potassium ion transport GO:0043266 10 5 0,000 2,108E-03 0,02588351 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 2,108E-03 0,0257541 ! apoptotic cell clearance GO:0043277 23 5 0,000 2,108E-03 0,02562597 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 2,108E-03 0,0254991 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 2,108E-03 0,02537349 ! lipoprotein particle clearance GO:0034381 10 5 0,000 2,108E-03 0,02524911 ! grooming behavior GO:0007625 6 5 0,000 2,108E-03 0,02512595 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 2,108E-03 0,02500398 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 2,108E-03 0,02488318 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 2,108E-03 0,02476355 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 2,108E-03 0,02464507 ! response to protozoan GO:0001562 13 5 0,000 2,108E-03 0,02452771 ! positive regulation of glycolysis GO:0045821 13 5 0,000 2,108E-03 0,02441146 ! lymph vessel development GO:0001945 10 5 0,000 2,108E-03 0,02429632 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 2,108E-03 0,02418225 ! endochondral ossification GO:0001958 17 5 0,000 2,108E-03 0,02406925 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 2,108E-03 0,0239573 ! single strand break repair GO:0000012 8 5 0,000 2,108E-03 0,02384638 ! parathyroid gland development GO:0060017 14 5 0,000 2,108E-03 0,02373649 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 2,108E-03 0,02362761 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 2,108E-03 0,02351972 ! cytokine secretion GO:0050663 15 5 0,000 2,108E-03 0,02341281 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 2,108E-03 0,02330687 ! ceramide catabolic process GO:0046514 7 5 0,000 2,108E-03 0,02320189 ! skeletal myofibril assembly GO:0014866 12 5 0,000 2,108E-03 0,02309784 ! smooth muscle tissue development GO:0048745 32 5 0,000 2,108E-03 0,02299473 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 2,108E-03 0,02289253 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 2,108E-03 0,02279123 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 2,108E-03 0,02269083 ! cardiac muscle fiber development GO:0048739 12 5 0,000 2,108E-03 0,02259131 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 2,108E-03 0,02249266 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 2,108E-03 0,02239487 ! neutrophil mediated immunity GO:0002446 7 5 0,000 2,108E-03 0,02229792 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 2,108E-03 0,02220181 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 2,108E-03 0,02210652 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 2,108E-03 0,02201205 ! glycine biosynthetic process GO:0006545 7 5 0,000 2,108E-03 0,02191838 ! microvillus organization GO:0032528 8 5 0,000 2,108E-03 0,0218255 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 2,108E-03 0,02173341 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 2,108E-03 0,0216421 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 2,108E-03 0,02155154 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 2,108E-03 0,02146175 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 2,108E-03 0,02137269 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 2,108E-03 0,02128438 ! polyol catabolic process GO:0046174 9 5 0,000 2,108E-03 0,02119679 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 2,108E-03 0,02110991 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 2,108E-03 0,02102375 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 2,108E-03 0,02093829 ! muscle cell migration GO:0014812 8 5 0,000 2,108E-03 0,02085352 ! mitochondrial fission GO:0000266 8 5 0,000 2,108E-03 0,02076943 ! sister chromatid cohesion GO:0007062 15 5 0,000 2,108E-03 0,02068602 ! response to tumor necrosis factor GO:0034612 10 5 0,000 2,108E-03 0,02060328 ! mRNA transcription GO:0009299 10 5 0,000 2,108E-03 0,02052119 ! nerve growth factor processing GO:0032455 9 5 0,000 2,108E-03 0,02043976 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 2,108E-03 0,02035897 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 2,108E-03 0,02027882 ! anaerobic glycolysis GO:0019642 6 5 0,000 2,108E-03 0,02019929 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 2,108E-03 0,02012039 ! monocyte activation GO:0042117 10 5 0,000 2,108E-03 0,0200421 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 2,108E-03 0,01996441 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 2,108E-03 0,01988733 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 2,108E-03 0,01981084 ! positive regulation of transporter activity GO:0032411 8 5 0,000 2,108E-03 0,01973494 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 2,108E-03 0,01965961 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 2,108E-03 0,01958486 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 2,108E-03 0,01951068 ! forebrain neuron development GO:0021884 13 5 0,000 2,108E-03 0,01943705 ! lipoprotein catabolic process GO:0042159 11 5 0,000 2,108E-03 0,01936398 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 2,108E-03 0,01929146 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 2,108E-03 0,01921947 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 2,108E-03 0,01914803 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 2,108E-03 0,01907711 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 2,108E-03 0,01900671 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 2,108E-03 0,01893683 ! lipid glycosylation GO:0030259 7 5 0,000 2,108E-03 0,01886747 ! nucleobase transport GO:0015851 6 5 0,000 2,108E-03 0,01879861 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 2,108E-03 0,01873025 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 2,108E-03 0,01866239 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 2,108E-03 0,01859501 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 2,108E-03 0,01852813 ! basic amino acid transport GO:0015802 12 5 0,000 2,108E-03 0,01846172 ! cellular glucose homeostasis GO:0001678 6 5 0,000 2,108E-03 0,01839578 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 2,108E-03 0,01833032 ! actin nucleation GO:0045010 11 5 0,000 2,108E-03 0,01826532 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 2,108E-03 0,01820077 ! depurination GO:0045007 5 5 0,000 2,108E-03 0,01813669 ! depyrimidination GO:0045008 10 5 0,000 2,108E-03 0,01807305 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 2,108E-03 0,01800986 ! regulation of centrosome cycle GO:0046605 7 5 0,000 2,108E-03 0,0179471 ! G2/M transition checkpoint GO:0031576 8 5 0,000 2,108E-03 0,01788479 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 2,108E-03 0,0178229 ! zinc ion homeostasis GO:0055069 9 5 0,000 2,108E-03 0,01776144 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 2,108E-03 0,01770041 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 2,108E-03 0,01763979 ! forebrain morphogenesis GO:0048853 13 5 0,000 2,108E-03 0,01757959 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 2,108E-03 0,01751979 ! activated T cell proliferation GO:0050798 16 5 0,000 2,108E-03 0,0174604 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 2,108E-03 0,01740142 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 2,108E-03 0,01734283 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 2,108E-03 0,01728463 ! positive regulation of organ growth GO:0046622 6 5 0,000 2,108E-03 0,01722682 ! gamma-delta T cell activation GO:0046629 6 5 0,000 2,108E-03 0,0171694 ! response to arsenic GO:0046685 11 5 0,000 2,108E-03 0,01711236 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 2,108E-03 0,01705569 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 2,108E-03 0,0169994 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 2,108E-03 0,01694348 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 2,108E-03 0,01688793 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 2,108E-03 0,01683274 ! response to mercury ion GO:0046689 8 5 0,000 2,108E-03 0,01677791 ! response to cadmium ion GO:0046686 7 5 0,000 2,108E-03 0,01672344 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 2,108E-03 0,01666932 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 2,108E-03 0,01661555 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 2,108E-03 0,01656212 ! bile acid biosynthetic process GO:0006699 7 5 0,000 2,108E-03 0,01650904 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 2,108E-03 0,01645629 ! ganglioside catabolic process GO:0006689 12 5 0,000 2,108E-03 0,01640388 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 2,108E-03 0,01635181 ! decidualization GO:0046697 11 5 0,000 2,108E-03 0,01630006 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 2,108E-03 0,01624864 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 2,108E-03 0,01619754 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 2,108E-03 0,01614677 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 2,108E-03 0,01609631 ! embryonic cleavage GO:0040016 6 5 0,000 2,108E-03 0,01604617 ! peroxisome fission GO:0016559 5 5 0,000 2,108E-03 0,01599633 ! histone demethylation GO:0016577 13 5 0,000 2,108E-03 0,01594681 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 2,108E-03 0,01589759 ! mitotic recombination GO:0006312 9 5 0,000 2,108E-03 0,01584867 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 2,108E-03 0,01580006 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 2,108E-03 0,01575174 ! metaphase plate congression GO:0051310 7 5 0,000 2,108E-03 0,01570372 ! regulation of sterol transport GO:0032371 7 5 0,000 2,108E-03 0,01565598 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 2,108E-03 0,01560854 ! enteric nervous system development GO:0048484 8 5 0,000 2,108E-03 0,01556139 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 2,108E-03 0,01551452 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 2,108E-03 0,01546793 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 2,108E-03 0,01542161 ! muscle cell proliferation GO:0033002 12 5 0,000 2,108E-03 0,01537558 ! skeletal muscle regeneration GO:0043403 8 5 0,000 2,108E-03 0,01532982 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 2,108E-03 0,01528433 ! B cell homeostasis GO:0001782 13 5 0,000 2,108E-03 0,01523911 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 2,108E-03 0,01519416 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 2,108E-03 0,01514947 ! metaphase GO:0051323 11 5 0,000 2,108E-03 0,01510504 ! melatonin biosynthetic process GO:0030187 7 5 0,000 2,108E-03 0,01506087 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 2,108E-03 0,01501697 ! cellular response to nutrient GO:0031670 8 5 0,000 2,108E-03 0,01497331 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 2,108E-03 0,01492991 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 2,108E-03 0,01488676 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 2,108E-03 0,01484386 ! regulation of hair follicle development GO:0051797 10 5 0,000 2,108E-03 0,0148012 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 2,108E-03 0,01475879 ! response to redox state GO:0051775 6 5 0,000 2,108E-03 0,01471663 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 2,108E-03 0,0146747 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 2,108E-03 0,01463301 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 2,108E-03 0,01459156 ! brown fat cell differentiation GO:0050873 7 5 0,000 2,108E-03 0,01455034 ! regulation of telomerase activity GO:0051972 7 5 0,000 2,108E-03 0,01450935 ! galactolipid metabolic process GO:0019374 7 5 0,000 2,108E-03 0,01446859 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 2,108E-03 0,01442806 ! porphyrin catabolic process GO:0006787 12 5 0,000 2,108E-03 0,01438776 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 2,108E-03 0,01434769 ! striatum development GO:0021756 14 5 0,000 2,108E-03 0,01430783 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 2,108E-03 0,0142682 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 2,108E-03 0,01422878 ! glial cell migration GO:0008347 10 5 0,000 2,108E-03 0,01418958 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 2,108E-03 0,0141506 ! neural plate morphogenesis GO:0001839 7 5 0,000 2,108E-03 0,01411183 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 2,108E-03 0,01407328 ! somatic stem cell maintenance GO:0035019 15 5 0,000 2,108E-03 0,01403493 ! T cell activation during immune response GO:0002286 9 5 0,000 2,108E-03 0,01399679 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 2,108E-03 0,01395886 ! negative regulation of lipase activity GO:0060192 8 5 0,000 2,108E-03 0,01392113 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 2,108E-03 0,01388361 ! neuroprotection GO:0043526 8 5 0,000 2,108E-03 0,01384629 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 2,108E-03 0,01380917 ! regulation of sensory perception GO:0051931 8 5 0,000 2,108E-03 0,01377224 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 2,108E-03 0,01373552 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 2,108E-03 0,01369899 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 2,108E-03 0,01366265 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 2,108E-03 0,01362651 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 2,108E-03 0,01359055 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 2,108E-03 0,01355479 ! sequestering of calcium ion GO:0051208 7 5 0,000 2,108E-03 0,01351921 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 2,108E-03 0,01348382 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 2,108E-03 0,01344861 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 2,108E-03 0,01341359 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 2,108E-03 0,01337875 ! spindle assembly GO:0051225 6 5 0,000 2,108E-03 0,01334409 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 2,108E-03 0,01330961 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 2,108E-03 0,01327531 ! protein palmitoylation GO:0018345 12 5 0,000 2,108E-03 0,01324118 ! drug metabolic process GO:0017144 7 5 0,000 2,108E-03 0,01320723 ! stem cell division GO:0017145 11 5 0,000 2,108E-03 0,01317345 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 2,108E-03 0,01313984 ! organ regeneration GO:0031100 7 5 0,000 2,108E-03 0,01310641 ! carnitine metabolic process GO:0009437 8 5 0,000 2,108E-03 0,01307314 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 2,108E-03 0,01304005 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 2,53E-03 0,01560547 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 2,53E-03 0,01556616 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 2,53E-03 0,01552705 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 2,53E-03 0,01548813 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 2,53E-03 0,01544941 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 2,53E-03 0,01541089 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 2,53E-03 0,01537255 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 2,53E-03 0,01533441 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 2,53E-03 0,01529645 ! response to oxygen radical GO:0000305 11 6 0,000 2,53E-03 0,01525868 ! positive regulation of axon extension GO:0045773 13 6 0,000 2,53E-03 0,0152211 ! myoblast cell fate commitment GO:0048625 18 6 0,000 2,53E-03 0,0151837 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 2,53E-03 0,01514648 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 2,53E-03 0,01510945 ! regulation of interferon-beta production GO:0032648 8 6 0,000 2,53E-03 0,0150726 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 2,53E-03 0,01503593 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 2,53E-03 0,01499943 ! forebrain regionalization GO:0021871 9 6 0,000 2,53E-03 0,01496311 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 2,53E-03 0,01492697 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 2,53E-03 0,014891 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 2,53E-03 0,01485521 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 2,53E-03 0,01481958 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 2,53E-03 0,01478413 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 2,53E-03 0,01474884 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 2,53E-03 0,01471373 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 2,53E-03 0,01467878 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 2,53E-03 0,01464399 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 2,53E-03 0,01460938 ! malate metabolic process GO:0006108 13 6 0,000 2,53E-03 0,01457492 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 2,53E-03 0,01454063 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 2,53E-03 0,01450649 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 2,53E-03 0,01447252 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 2,53E-03 0,01443871 ! protein refolding GO:0042026 15 6 0,000 2,53E-03 0,01440505 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 2,53E-03 0,01437155 ! opsonization GO:0008228 8 6 0,000 2,53E-03 0,0143382 ! mating behavior GO:0007617 7 6 0,000 2,53E-03 0,01430501 ! erythrocyte maturation GO:0043249 8 6 0,000 2,53E-03 0,01427198 ! embryonic hemopoiesis GO:0035162 16 6 0,000 2,53E-03 0,01423909 ! protein amino acid dealkylation GO:0008214 15 6 0,000 2,53E-03 0,01420636 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 2,53E-03 0,01417377 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 2,53E-03 0,01414134 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 2,53E-03 0,01410905 ! response to interferon-gamma GO:0034341 16 6 0,000 2,53E-03 0,01407692 ! toxin metabolic process GO:0009404 11 6 0,000 2,53E-03 0,01404492 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 2,53E-03 0,01401307 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 2,53E-03 0,01398137 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 2,53E-03 0,01394981 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 2,53E-03 0,01391839 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 2,53E-03 0,01388711 ! cGMP-mediated signaling GO:0019934 14 6 0,000 2,53E-03 0,01385598 ! dorsal spinal cord development GO:0021516 10 6 0,000 2,53E-03 0,01382498 ! activation of MAPKKK activity GO:0000185 12 6 0,000 2,53E-03 0,01379412 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 2,53E-03 0,0137634 ! thymic T cell selection GO:0045061 16 6 0,000 2,53E-03 0,01373281 ! sphingoid catabolic process GO:0046521 8 6 0,000 2,53E-03 0,01370236 ! protein lipoylation GO:0009249 10 6 0,000 2,53E-03 0,01367205 ! transepithelial chloride transport GO:0030321 12 6 0,000 2,53E-03 0,01364187 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 2,53E-03 0,01361182 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 2,53E-03 0,0135819 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 2,53E-03 0,01355212 ! glutamate catabolic process GO:0006538 12 6 0,000 2,53E-03 0,01352246 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 2,53E-03 0,01349294 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 2,53E-03 0,01346354 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 2,53E-03 0,01343427 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 2,53E-03 0,01340513 ! hyperosmotic response GO:0006972 10 6 0,000 2,53E-03 0,01337612 ! L-serine biosynthetic process GO:0006564 7 6 0,000 2,53E-03 0,01334723 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 2,53E-03 0,01331846 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 2,53E-03 0,01328982 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 2,53E-03 0,0132613 ! urea metabolic process GO:0019627 7 6 0,000 2,53E-03 0,0132329 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 2,53E-03 0,01320463 ! neutrophil activation GO:0042119 7 6 0,000 2,53E-03 0,01317647 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 2,53E-03 0,01314844 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 2,53E-03 0,01312052 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 2,53E-03 0,01309272 ! paraxial mesoderm development GO:0048339 16 6 0,000 2,53E-03 0,01306504 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 2,53E-03 0,01303748 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 2,53E-03 0,01301003 ! neuron apoptosis GO:0051402 15 6 0,000 2,53E-03 0,0129827 ! T cell mediated immunity GO:0002456 17 6 0,000 2,53E-03 0,01295548 ! negative regulation of platelet activation GO:0010544 9 6 0,000 2,53E-03 0,01292838 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 2,53E-03 0,01290139 ! carnitine transport GO:0015879 10 6 0,000 2,53E-03 0,01287451 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 2,53E-03 0,01284775 ! positive regulation of exocytosis GO:0045921 11 6 0,000 2,53E-03 0,01282109 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 2,53E-03 0,01279455 ! early endosome to late endosome transport GO:0045022 16 6 0,000 2,53E-03 0,01276811 ! 5S class rRNA transcription GO:0042791 13 6 0,000 2,53E-03 0,01274179 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 2,53E-03 0,01271557 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 2,53E-03 0,01268946 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 2,53E-03 0,01266345 ! sodium ion homeostasis GO:0055078 12 6 0,000 2,53E-03 0,01263756 ! establishment of spindle localization GO:0051293 16 6 0,000 2,53E-03 0,01261177 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 2,53E-03 0,01258608 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 2,53E-03 0,0125605 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 2,53E-03 0,01253502 ! response to UV-C GO:0010225 14 6 0,000 2,53E-03 0,01250965 ! astrocyte development GO:0014002 16 6 0,000 2,53E-03 0,01248438 ! protein targeting to lysosome GO:0006622 12 6 0,000 2,53E-03 0,01245921 ! purine base biosynthetic process GO:0009113 17 6 0,000 2,53E-03 0,01243414 ! interaction with symbiont GO:0051702 14 6 0,000 2,53E-03 0,01240917 ! regulation of dendrite development GO:0050773 16 6 0,000 2,53E-03 0,0123843 ! peptidyl-arginine modification GO:0018195 13 6 0,000 2,53E-03 0,01235953 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 2,53E-03 0,01233486 ! response to copper ion GO:0046688 10 6 0,000 2,53E-03 0,01231029 ! response to exogenous dsRNA GO:0043330 13 6 0,000 2,53E-03 0,01228582 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 2,53E-03 0,01226144 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 2,53E-03 0,01223716 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 2,53E-03 0,01221298 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 2,53E-03 0,01218889 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 2,53E-03 0,01216489 ! regulation of dopamine secretion GO:0014059 14 6 0,000 2,53E-03 0,01214099 ! nucleoside catabolic process GO:0009164 10 6 0,000 2,53E-03 0,01211719 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 2,53E-03 0,01209348 ! Schwann cell development GO:0014044 15 6 0,000 2,53E-03 0,01206986 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 2,53E-03 0,01204633 ! response to pheromone GO:0019236 6 6 0,000 2,53E-03 0,01202289 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 2,53E-03 0,01199955 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 2,53E-03 0,01197629 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 2,53E-03 0,01195313 ! base conversion or substitution editing GO:0016553 6 6 0,000 2,53E-03 0,01193005 ! subpallium development GO:0021544 15 6 0,000 2,53E-03 0,01190706 ! neural tube patterning GO:0021532 8 6 0,000 2,53E-03 0,01188416 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 2,53E-03 0,01186135 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 2,53E-03 0,01183863 ! maintenance of organ identity GO:0048496 9 6 0,000 2,53E-03 0,011816 ! G2 phase GO:0051319 16 6 0,000 2,53E-03 0,01179345 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 2,53E-03 0,01177098 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 2,53E-03 0,0117486 ! oxygen homeostasis GO:0032364 10 6 0,000 2,53E-03 0,01172631 ! establishment of planar polarity GO:0001736 7 6 0,000 2,53E-03 0,0117041 ! regulation of mast cell activation GO:0033003 13 6 0,000 2,53E-03 0,01168198 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 2,53E-03 0,01165994 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 2,53E-03 0,01163798 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 2,53E-03 0,0116161 ! receptor internalization GO:0031623 11 6 0,000 2,53E-03 0,01159431 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 2,53E-03 0,0115726 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 2,53E-03 0,01155096 ! neutrophil homeostasis GO:0001780 11 6 0,000 2,53E-03 0,01152941 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 2,53E-03 0,01150794 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 2,53E-03 0,01148655 ! protein deubiquitination GO:0016579 16 6 0,000 2,53E-03 0,01146524 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 2,53E-03 0,01144401 ! protein destabilization GO:0031648 9 6 0,000 2,53E-03 0,01142286 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 2,53E-03 0,01140178 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 2,53E-03 0,01138078 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 2,53E-03 0,01135986 ! regulation of viral transcription GO:0046782 11 6 0,000 2,53E-03 0,01133902 ! progesterone metabolic process GO:0042448 12 6 0,000 2,53E-03 0,01131825 ! negative regulation of axon extension GO:0030517 24 6 0,000 2,53E-03 0,01129756 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 2,53E-03 0,01127694 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 2,53E-03 0,0112564 ! triglyceride catabolic process GO:0019433 10 6 0,000 2,53E-03 0,01123594 ! determination of adult lifespan GO:0008340 17 6 0,000 2,53E-03 0,01121555 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 2,53E-03 0,01119523 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 2,53E-03 0,01117498 ! neural plate development GO:0001840 9 6 0,000 2,53E-03 0,01115481 ! catecholamine transport GO:0051937 9 6 0,000 2,53E-03 0,01113471 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 2,53E-03 0,01111469 ! sensory cilium assembly GO:0035058 10 6 0,000 2,53E-03 0,01109473 ! organ or tissue specific immune response GO:0002251 8 6 0,000 2,53E-03 0,01107485 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 2,53E-03 0,01105504 ! maternal placenta development GO:0001893 12 6 0,000 2,53E-03 0,0110353 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 2,53E-03 0,01101563 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 2,53E-03 0,01099602 ! negative regulation of B cell activation GO:0050869 14 6 0,000 2,53E-03 0,01097649 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 2,53E-03 0,01095703 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 2,53E-03 0,01093764 ! positive regulation of coagulation GO:0050820 13 6 0,000 2,53E-03 0,01091831 ! cellular anion homeostasis GO:0030002 11 6 0,000 2,53E-03 0,01089906 GO:0055081|anion homeostasis, ! tRNA transcription GO:0009304 17 7 0,000 2,951E-03 0,01269068 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 2,951E-03 0,01266838 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 2,951E-03 0,01264615 ! behavioral response to cocaine GO:0048148 14 7 0,000 2,951E-03 0,01262401 ! regulation of helicase activity GO:0051095 16 7 0,000 2,951E-03 0,01260194 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 2,951E-03 0,01257994 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 2,951E-03 0,01255803 ! sleep GO:0030431 16 7 0,000 2,951E-03 0,01253619 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 2,951E-03 0,01251442 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 2,951E-03 0,01249273 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 2,951E-03 0,01247112 ! prostate gland development GO:0030850 14 7 0,000 2,951E-03 0,01244958 ! nucleotide-sugar transport GO:0015780 11 7 0,000 2,951E-03 0,01242812 ! synaptonemal complex assembly GO:0007130 10 7 0,000 2,951E-03 0,01240672 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 2,951E-03 0,01238541 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 2,951E-03 0,01236416 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 2,951E-03 0,01234299 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 2,951E-03 0,01232189 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 2,951E-03 0,01230087 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 2,951E-03 0,01227991 ! SMAD protein complex assembly GO:0007183 13 7 0,000 2,951E-03 0,01225903 ! glycolipid transport GO:0046836 11 7 0,000 2,951E-03 0,01223821 ! protein amino acid sulfation GO:0006477 10 7 0,000 2,951E-03 0,01221747 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 2,951E-03 0,0121968 ! neuron adhesion GO:0007158 14 7 0,000 2,951E-03 0,01217619 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 2,951E-03 0,01215566 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 2,951E-03 0,0121352 ! establishment of tissue polarity GO:0007164 8 7 0,000 2,951E-03 0,0121148 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 2,951E-03 0,01209448 ! mRNA stabilization GO:0048255 18 7 0,000 2,951E-03 0,01207422 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 2,951E-03 0,01205403 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 2,951E-03 0,0120339 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 2,951E-03 0,01201385 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 2,951E-03 0,01199386 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 2,951E-03 0,01197393 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 2,951E-03 0,01195407 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 2,951E-03 0,01193428 ! lipoprotein transport GO:0042953 14 7 0,000 2,951E-03 0,01191456 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 2,951E-03 0,0118949 ! rhythmic behavior GO:0007622 17 7 0,000 2,951E-03 0,0118753 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 2,951E-03 0,01185577 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 2,951E-03 0,0118363 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 2,951E-03 0,0118169 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 2,951E-03 0,01179756 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 2,951E-03 0,01177828 ! regulation of odontogenesis GO:0042481 14 7 0,000 2,951E-03 0,01175907 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 2,951E-03 0,01173991 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 2,951E-03 0,01172082 ! mechanosensory behavior GO:0007638 16 7 0,000 2,951E-03 0,0117018 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 2,951E-03 0,01168283 ! positive regulation of isotype switching GO:0045830 17 7 0,000 2,951E-03 0,01166393 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 2,951E-03 0,01164508 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 2,951E-03 0,0116263 ! protein-cofactor linkage GO:0018065 13 7 0,000 2,951E-03 0,01160758 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 2,951E-03 0,01158892 ! spinal cord patterning GO:0021511 14 7 0,000 2,951E-03 0,01157032 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 2,951E-03 0,01155177 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 2,951E-03 0,01153329 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 2,951E-03 0,01151487 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 2,951E-03 0,0114965 ! adrenal gland development GO:0030325 17 7 0,000 2,951E-03 0,0114782 ! cysteine metabolic process GO:0006534 13 7 0,000 2,951E-03 0,01145995 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 2,951E-03 0,01144176 ! ovulation GO:0030728 10 7 0,000 2,951E-03 0,01142362 ! adenohypophysis development GO:0021984 11 7 0,000 2,951E-03 0,01140555 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 2,951E-03 0,01138753 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 2,951E-03 0,01136957 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 2,951E-03 0,01135166 ! microtubule nucleation GO:0007020 21 7 0,000 2,951E-03 0,01133382 ! proline biosynthetic process GO:0006561 10 7 0,000 2,951E-03 0,01131602 ! tryptophan metabolic process GO:0006568 11 7 0,000 2,951E-03 0,01129829 ! thyroid hormone generation GO:0006590 13 7 0,000 2,951E-03 0,01128061 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 2,951E-03 0,01126298 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 2,951E-03 0,01124541 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 2,951E-03 0,01122789 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 2,951E-03 0,01121043 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 2,951E-03 0,01119302 ! galactose metabolic process GO:0006012 13 7 0,000 2,951E-03 0,01117567 ! vesicle fusion GO:0006906 20 7 0,000 2,951E-03 0,01115837 ! response to dietary excess GO:0002021 8 7 0,000 2,951E-03 0,01114112 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 2,951E-03 0,01112393 ! intracellular pH reduction GO:0051452 13 7 0,000 2,951E-03 0,01110679 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 2,951E-03 0,0110897 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 2,951E-03 0,01107267 ! organ growth GO:0035265 15 7 0,000 2,951E-03 0,01105569 ! nucleoside transport GO:0015858 11 7 0,000 2,951E-03 0,01103876 ! nucleoside salvage GO:0043174 11 7 0,000 2,951E-03 0,01102188 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 2,951E-03 0,01100505 ! male sex determination GO:0030238 15 7 0,000 2,951E-03 0,01098827 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 2,951E-03 0,01097155 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 2,951E-03 0,01095487 ! parturition GO:0007567 16 7 0,000 2,951E-03 0,01093825 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 2,951E-03 0,01092168 ! rRNA modification GO:0000154 14 7 0,000 2,951E-03 0,01090515 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 2,951E-03 0,01088868 ! spindle checkpoint GO:0031577 16 7 0,000 2,951E-03 0,01087226 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 2,951E-03 0,01085588 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 2,951E-03 0,01083956 ! monocyte differentiation GO:0030224 16 7 0,000 2,951E-03 0,01082328 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 2,951E-03 0,01080706 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 2,951E-03 0,01079088 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 2,951E-03 0,01077475 ! hyaluronan metabolic process GO:0030212 9 7 0,000 2,951E-03 0,01075867 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 2,951E-03 0,01074263 ! anterograde axon cargo transport GO:0008089 18 7 0,000 2,951E-03 0,01072665 ! fibrinolysis GO:0042730 11 7 0,000 2,951E-03 0,01071071 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 2,951E-03 0,01069482 ! skeletal muscle contraction GO:0003009 8 7 0,000 2,951E-03 0,01067897 ! eating behavior GO:0042755 8 7 0,000 2,951E-03 0,01066318 ! B cell lineage commitment GO:0002326 21 7 0,000 2,951E-03 0,01064743 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 2,951E-03 0,01063172 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 2,951E-03 0,01061606 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 2,951E-03 0,01060045 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 2,951E-03 0,01058489 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 2,951E-03 0,01056937 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 2,951E-03 0,01055389 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 2,951E-03 0,01053846 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 2,951E-03 0,01052308 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 2,951E-03 0,01050774 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 2,951E-03 0,01049244 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 2,951E-03 0,01047719 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 2,951E-03 0,01046198 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 2,951E-03 0,01044682 ! regulation of meiosis GO:0040020 12 7 0,000 2,951E-03 0,0104317 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 2,951E-03 0,01041663 ! T cell lineage commitment GO:0002360 16 7 0,000 2,951E-03 0,0104016 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 2,951E-03 0,01038661 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 2,951E-03 0,01037166 ! membrane to membrane docking GO:0022614 14 7 0,000 2,951E-03 0,01035676 ! transcription termination GO:0006353 14 7 0,000 2,951E-03 0,0103419 ! coenzyme A metabolic process GO:0015936 12 7 0,000 2,951E-03 0,01032709 ! anaphase GO:0051322 18 7 0,000 2,951E-03 0,01031231 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 2,951E-03 0,01029758 ! axonal fasciculation GO:0007413 19 7 0,000 2,951E-03 0,01028289 ! negative regulation of nuclear division GO:0051784 15 7 0,000 2,951E-03 0,01026824 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 2,951E-03 0,01025364 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 2,951E-03 0,01023907 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 2,951E-03 0,01022455 ! diuresis GO:0030146 12 7 0,000 2,951E-03 0,01021007 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 2,951E-03 0,01019563 ! thiamin metabolic process GO:0006772 7 7 0,000 2,951E-03 0,01018122 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 2,951E-03 0,01016686 ! antibiotic transport GO:0042891 9 7 0,000 2,951E-03 0,01015255 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 2,951E-03 0,01013827 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 2,951E-03 0,01012403 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 2,951E-03 0,01010983 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 2,951E-03 0,01009567 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 2,951E-03 0,01008155 ! melanin biosynthetic process GO:0042438 10 7 0,000 2,951E-03 0,01006747 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 2,951E-03 0,01005343 ! dopamine biosynthetic process GO:0042416 18 7 0,000 2,951E-03 0,01003942 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 2,951E-03 0,01002546 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 2,951E-03 0,01001154 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 2,951E-03 9,998E-03 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 2,951E-03 9,984E-03 ! endosome to lysosome transport GO:0008333 12 7 0,000 2,951E-03 9,97E-03 ! protein modification by small protein removal GO:0070646 19 7 0,000 2,951E-03 9,956E-03 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 2,951E-03 9,942E-03 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 2,951E-03 9,929E-03 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 2,951E-03 9,915E-03 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 2,951E-03 9,902E-03 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 2,951E-03 9,888E-03 ! muscle adaptation GO:0043500 13 7 0,000 2,951E-03 9,874E-03 ! embryonic heart tube development GO:0035050 14 7 0,000 2,951E-03 9,861E-03 ! retina homeostasis GO:0001895 12 7 0,000 2,951E-03 9,847E-03 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 2,951E-03 9,834E-03 ! protein amino acid prenylation GO:0018346 19 7 0,000 2,951E-03 9,821E-03 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 2,951E-03 9,807E-03 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 2,951E-03 9,794E-03 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 3,371E-03 0,01117564 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 3,371E-03 0,01116049 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 3,371E-03 0,01114539 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 3,371E-03 0,01113033 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 3,371E-03 0,01111531 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 3,371E-03 0,01110033 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 3,371E-03 0,01108539 ! male meiosis GO:0007140 9 8 0,000 3,371E-03 0,01107049 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 3,371E-03 0,01105563 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 3,371E-03 0,01104081 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 3,371E-03 0,01102603 ! meiotic prophase I GO:0007128 14 8 0,000 3,371E-03 0,01101129 ! response to zinc ion GO:0010043 12 8 0,000 3,371E-03 0,01099659 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 3,371E-03 0,01098192 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 3,371E-03 0,0109673 ! oligopeptide transport GO:0006857 16 8 0,000 3,371E-03 0,01095272 ! actin-myosin filament sliding GO:0033275 13 8 0,000 3,371E-03 0,01093817 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 3,371E-03 0,01092366 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 3,371E-03 0,0109092 ! signal peptide processing GO:0006465 12 8 0,000 3,371E-03 0,01089477 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 3,371E-03 0,01088037 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 3,371E-03 0,01086602 ! macrophage chemotaxis GO:0048246 12 8 0,000 3,371E-03 0,0108517 ! succinate metabolic process GO:0006105 17 8 0,000 3,371E-03 0,01083743 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 3,371E-03 0,01082318 ! membrane hyperpolarization GO:0060081 11 8 0,000 3,371E-03 0,01080898 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 3,371E-03 0,01079481 ! estrogen metabolic process GO:0008210 17 8 0,000 3,371E-03 0,01078068 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 3,371E-03 0,01076659 ! T-helper 1 type immune response GO:0042088 12 8 0,000 3,371E-03 0,01075254 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 3,371E-03 0,01073852 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 3,371E-03 0,01072454 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 3,371E-03 0,01071059 ! reflex GO:0060004 17 8 0,000 3,371E-03 0,01069668 ! endothelial cell differentiation GO:0045446 17 8 0,000 3,371E-03 0,01068281 ! glycerolipid catabolic process GO:0046503 14 8 0,000 3,371E-03 0,01066897 ! hemoglobin metabolic process GO:0020027 14 8 0,000 3,371E-03 0,01065517 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 3,371E-03 0,0106414 ! pigment granule organization GO:0048753 17 8 0,000 3,371E-03 0,01062767 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 3,371E-03 0,01061397 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 3,371E-03 0,01060031 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 3,371E-03 0,01058669 ! astrocyte differentiation GO:0048708 19 8 0,000 3,371E-03 0,0105731 ! histidine catabolic process GO:0006548 10 8 0,000 3,371E-03 0,01055954 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 3,371E-03 0,01054602 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 3,371E-03 0,01053254 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 3,371E-03 0,01051908 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 3,371E-03 0,01050567 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 3,371E-03 0,01049228 ! regulation of pigmentation during development GO:0048070 25 8 0,000 3,371E-03 0,01047894 ! melanin metabolic process GO:0006582 17 8 0,000 3,371E-03 0,01046562 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 3,371E-03 0,01045234 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 3,371E-03 0,01043909 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 3,371E-03 0,01042588 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 3,371E-03 0,0104127 ! macrophage activation GO:0042116 13 8 0,000 3,371E-03 0,01039955 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 3,371E-03 0,01038644 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 3,371E-03 0,01037335 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 3,371E-03 0,01036031 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 3,371E-03 0,01034729 ! purine salvage GO:0043101 12 8 0,000 3,371E-03 0,01033431 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 3,371E-03 0,01032136 ! regulation of vascular permeability GO:0043114 12 8 0,000 3,371E-03 0,01030844 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 3,371E-03 0,01029555 ! osteoblast development GO:0002076 17 8 0,000 3,371E-03 0,0102827 ! positive regulation of vasodilation GO:0045909 14 8 0,000 3,371E-03 0,01026988 ! negative regulation of translational initiation GO:0045947 12 8 0,000 3,371E-03 0,01025709 ! Schwann cell differentiation GO:0014037 21 8 0,000 3,371E-03 0,01024433 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 3,371E-03 0,01023161 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 3,371E-03 0,01021891 ! response to UV-B GO:0010224 17 8 0,000 3,371E-03 0,01020625 ! protein targeting to vacuole GO:0006623 14 8 0,000 3,371E-03 0,01019362 ! protein retention in ER lumen GO:0006621 14 8 0,000 3,371E-03 0,01018102 ! intermediate filament organization GO:0045109 12 8 0,000 3,371E-03 0,01016845 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 3,371E-03 0,01015591 ! cellular extravasation GO:0045123 13 8 0,000 3,371E-03 0,0101434 ! cardiac muscle cell development GO:0055013 14 8 0,000 3,371E-03 0,01013093 ! response to antibiotic GO:0046677 11 8 0,000 3,371E-03 0,01011848 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 3,371E-03 0,01010607 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 3,371E-03 0,01009368 ! DNA topological change GO:0006265 12 8 0,000 3,371E-03 0,01008133 ! response to tropane GO:0014073 15 8 0,000 3,371E-03 0,010069 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 3,371E-03 0,01005671 ! melanosome transport GO:0032402 13 8 0,000 3,371E-03 0,01004444 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 0,000 3,371E-03 0,01003221 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 3,371E-03 0,01002 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 3,371E-03 0,01000783 ! mast cell activation GO:0045576 14 8 0,000 3,371E-03 9,996E-03 ! multicellular organismal aging GO:0010259 20 8 0,000 3,371E-03 9,984E-03 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 3,371E-03 9,971E-03 ! gas homeostasis GO:0033483 14 8 0,000 3,371E-03 9,959E-03 ! dendrite morphogenesis GO:0048813 14 8 0,000 3,371E-03 9,947E-03 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 3,371E-03 9,935E-03 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 3,371E-03 9,923E-03 ! nucleosome disassembly GO:0006337 14 8 0,000 3,371E-03 9,911E-03 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 3,371E-03 9,9E-03 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 3,371E-03 9,888E-03 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 3,371E-03 9,876E-03 ! establishment of chromosome localization GO:0051303 14 8 0,000 3,371E-03 9,864E-03 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 3,371E-03 9,852E-03 ! intracellular lipid transport GO:0032365 16 8 0,000 3,371E-03 9,84E-03 ! response to tumor cell GO:0002347 16 8 0,000 3,371E-03 9,829E-03 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 3,371E-03 9,817E-03 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 3,371E-03 9,805E-03 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 3,371E-03 9,794E-03 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 3,371E-03 9,782E-03 ! positive regulation of epidermis development GO:0045684 13 8 0,000 3,371E-03 9,77E-03 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 3,371E-03 9,759E-03 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 3,371E-03 9,747E-03 ! hormone catabolic process GO:0042447 17 8 0,000 3,371E-03 9,736E-03 ! glycolipid catabolic process GO:0019377 16 8 0,000 3,371E-03 9,724E-03 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 3,371E-03 9,713E-03 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 3,371E-03 9,701E-03 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 3,371E-03 9,69E-03 ! positive regulation of glucose import GO:0046326 8 8 0,000 3,371E-03 9,679E-03 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 3,371E-03 9,667E-03 ! adult feeding behavior GO:0008343 10 8 0,000 3,371E-03 9,656E-03 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 3,371E-03 9,645E-03 ! ATP catabolic process GO:0006200 11 8 0,000 3,371E-03 9,633E-03 ! blastocyst growth GO:0001832 19 8 0,000 3,371E-03 9,622E-03 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 3,371E-03 9,611E-03 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 3,371E-03 9,6E-03 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 3,371E-03 9,588E-03 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 3,371E-03 9,577E-03 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 3,371E-03 9,566E-03 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 3,371E-03 9,555E-03 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 3,371E-03 9,544E-03 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 3,371E-03 9,533E-03 ! amino sugar catabolic process GO:0046348 11 8 0,000 3,371E-03 9,522E-03 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 3,371E-03 9,511E-03 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 3,371E-03 9,5E-03 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 3,371E-03 9,489E-03 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 3,371E-03 9,478E-03 ! behavioral response to nicotine GO:0035095 12 8 0,000 3,371E-03 9,467E-03 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 3,371E-03 9,456E-03 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 3,371E-03 9,445E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 3,371E-03 9,435E-03 ! NAD biosynthetic process GO:0009435 17 8 0,000 3,371E-03 9,424E-03 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 3,371E-03 9,413E-03 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 3,371E-03 9,402E-03 ! axon extension GO:0048675 16 9 0,000 3,792E-03 0,01056348 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 3,792E-03 0,01055145 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 3,792E-03 0,01053945 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 3,792E-03 0,01052747 ! pentose-phosphate shunt GO:0006098 16 9 0,000 3,792E-03 0,01051552 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 3,792E-03 0,0105036 ! cell proliferation in forebrain GO:0021846 18 9 0,000 3,792E-03 0,0104917 ! neutral lipid catabolic process GO:0046461 14 9 0,000 3,792E-03 0,01047984 ! reproductive behavior GO:0019098 22 9 0,000 3,792E-03 0,01046799 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 3,792E-03 0,01045618 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 3,792E-03 0,01044439 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 3,792E-03 0,01043263 ! UTP metabolic process GO:0046051 10 9 0,000 3,792E-03 0,01042089 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 3,792E-03 0,01040918 ! induction of positive chemotaxis GO:0050930 17 9 0,000 3,792E-03 0,0103975 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 3,792E-03 0,01038585 ! artery development GO:0060840 25 9 0,000 3,792E-03 0,01037422 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 3,792E-03 0,01036261 ! regulation of glycolysis GO:0006110 20 9 0,000 3,792E-03 0,01035103 ! cerebral cortex cell migration GO:0021795 18 9 0,000 3,792E-03 0,01033948 ! equilibrioception GO:0050957 20 9 0,000 3,792E-03 0,01032795 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 3,792E-03 0,01031645 ! chemosensory behavior GO:0007635 21 9 0,000 3,792E-03 0,01030498 ! microtubule bundle formation GO:0001578 22 9 0,000 3,792E-03 0,01029353 ! middle ear morphogenesis GO:0042474 14 9 0,000 3,792E-03 0,0102821 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 3,792E-03 0,0102707 ! leukocyte degranulation GO:0043299 16 9 0,000 3,792E-03 0,01025933 ! ganglioside metabolic process GO:0001573 22 9 0,000 3,792E-03 0,01024798 ! negative regulation of endocytosis GO:0045806 12 9 0,000 3,792E-03 0,01023666 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 3,792E-03 0,01022536 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 3,792E-03 0,01021408 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 3,792E-03 0,01020284 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 3,792E-03 0,01019161 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 3,792E-03 0,01018041 ! protein targeting to ER GO:0045047 25 9 0,000 3,792E-03 0,01016924 ! ceramide biosynthetic process GO:0046513 20 9 0,000 3,792E-03 0,01015809 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 3,792E-03 0,01014696 ! T cell selection GO:0045058 27 9 0,000 3,792E-03 0,01013586 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 3,792E-03 0,01012478 ! glycine catabolic process GO:0006546 15 9 0,000 3,792E-03 0,01011373 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 3,792E-03 0,0101027 ! endosome organization GO:0007032 20 9 0,000 3,792E-03 0,01009169 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 3,792E-03 0,01008071 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 3,792E-03 0,01006975 ! regulation of type I interferon production GO:0032479 12 9 0,000 3,792E-03 0,01005882 ! mannose metabolic process GO:0006013 13 9 0,000 3,792E-03 0,01004791 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 3,792E-03 0,01003703 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 3,792E-03 0,01002616 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 3,792E-03 0,01001532 ! Rac protein signal transduction GO:0016601 20 9 0,000 3,792E-03 0,01000451 ! receptor clustering GO:0043113 20 9 0,000 3,792E-03 9,994E-03 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 3,792E-03 9,983E-03 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 3,792E-03 9,972E-03 ! retinol metabolic process GO:0042572 20 9 0,000 3,792E-03 9,961E-03 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 3,792E-03 9,951E-03 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 3,792E-03 9,94E-03 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 3,792E-03 9,929E-03 ! macrophage differentiation GO:0030225 15 9 0,000 3,792E-03 9,919E-03 ! oligodendrocyte development GO:0014003 11 9 0,000 3,792E-03 9,908E-03 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 3,792E-03 9,898E-03 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 3,792E-03 9,887E-03 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 3,792E-03 9,877E-03 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 3,792E-03 9,866E-03 ! response to amine stimulus GO:0014075 13 9 0,000 3,792E-03 9,856E-03 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 3,792E-03 9,845E-03 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 3,792E-03 9,835E-03 ! erythrocyte development GO:0048821 17 9 0,000 3,792E-03 9,824E-03 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 3,792E-03 9,814E-03 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 3,792E-03 9,803E-03 ! renal water homeostasis GO:0003091 15 9 0,000 3,792E-03 9,793E-03 ! postreplication repair GO:0006301 25 9 0,000 3,792E-03 9,783E-03 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 3,792E-03 9,772E-03 ! icosanoid secretion GO:0032309 15 9 0,000 3,792E-03 9,762E-03 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 3,792E-03 9,752E-03 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 3,792E-03 9,742E-03 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 3,792E-03 9,731E-03 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 3,792E-03 9,721E-03 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 3,792E-03 9,711E-03 ! sterol catabolic process GO:0016127 14 9 0,000 3,792E-03 9,701E-03 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 3,792E-03 9,691E-03 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 3,792E-03 9,68E-03 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 3,792E-03 9,67E-03 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 3,792E-03 9,66E-03 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 3,792E-03 9,65E-03 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 3,792E-03 9,64E-03 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 3,792E-03 9,63E-03 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 3,792E-03 9,62E-03 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 3,792E-03 9,61E-03 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 3,792E-03 9,6E-03 ! regulation of synaptogenesis GO:0051963 15 9 0,000 3,792E-03 9,59E-03 ! purine base metabolic process GO:0006144 25 9 0,000 3,792E-03 9,58E-03 ! pigment granule transport GO:0051904 17 9 0,000 3,792E-03 9,57E-03 ! regulation of telomere maintenance GO:0032204 17 9 0,000 3,792E-03 9,561E-03 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 3,792E-03 9,551E-03 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 3,792E-03 9,541E-03 ! regulation of muscle adaptation GO:0043502 14 9 0,000 3,792E-03 9,531E-03 ! regulation of amino acid transport GO:0051955 12 9 0,000 3,792E-03 9,521E-03 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 3,792E-03 9,511E-03 ! mitochondrion localization GO:0051646 18 9 0,000 3,792E-03 9,502E-03 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 4,213E-03 0,01054457 ! regulation of developmental growth GO:0048638 16 10 0,000 4,213E-03 0,01053378 ! autophagic vacuole formation GO:0000045 17 10 0,000 4,213E-03 0,01052301 ! negative regulation of blood pressure GO:0045776 26 10 0,000 4,213E-03 0,01051226 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 4,213E-03 0,01050153 ! associative learning GO:0008306 21 10 0,000 4,213E-03 0,01049083 ! regulation of phosphatase activity GO:0010921 28 10 0,000 4,213E-03 0,01048014 ! phosphate transport GO:0006817 24 10 0,000 4,213E-03 0,01046948 ! cell volume homeostasis GO:0006884 17 10 0,000 4,213E-03 0,01045884 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 4,213E-03 0,01044822 ! CTP metabolic process GO:0046036 11 10 0,000 4,213E-03 0,01043763 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 4,213E-03 0,01042705 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 4,213E-03 0,0104165 ! GTP metabolic process GO:0046039 11 10 0,000 4,213E-03 0,01040597 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 4,213E-03 0,01039546 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 4,213E-03 0,01038497 ! social behavior GO:0035176 29 10 0,000 4,213E-03 0,0103745 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 4,213E-03 0,01036405 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 4,213E-03 0,01035362 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 4,213E-03 0,01034322 ! androgen metabolic process GO:0008209 17 10 0,000 4,213E-03 0,01033283 ! phospholipid efflux GO:0033700 19 10 0,000 4,213E-03 0,01032247 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 4,213E-03 0,01031212 ! bile acid and bile salt transport GO:0015721 15 10 0,000 4,213E-03 0,0103018 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 4,213E-03 0,0102915 ! positive regulation of heart contraction GO:0045823 17 10 0,000 4,213E-03 0,01028122 ! lung alveolus development GO:0048286 26 10 0,000 4,213E-03 0,01027096 ! pathogenesis GO:0009405 17 10 0,000 4,213E-03 0,01026072 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 4,213E-03 0,0102505 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 4,213E-03 0,0102403 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 4,213E-03 0,01023012 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 4,213E-03 0,01021996 ! endoderm development GO:0007492 18 10 0,000 4,213E-03 0,01020982 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 4,213E-03 0,0101997 ! arginine catabolic process GO:0006527 17 10 0,000 4,213E-03 0,0101896 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 4,213E-03 0,01017953 ! proline metabolic process GO:0006560 13 10 0,000 4,213E-03 0,01016947 ! phosphagen metabolic process GO:0006599 17 10 0,000 4,213E-03 0,01015943 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 4,213E-03 0,01014941 ! V(D)J recombination GO:0033151 34 10 0,000 4,213E-03 0,01013941 ! reverse cholesterol transport GO:0043691 19 10 0,000 4,213E-03 0,01012943 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 4,213E-03 0,01011947 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 4,213E-03 0,01010953 ! B cell proliferation GO:0042100 19 10 0,000 4,213E-03 0,01009961 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 4,213E-03 0,01008971 ! regulation of sodium ion transport GO:0002028 26 10 0,000 4,213E-03 0,01007982 ! multicellular organism growth GO:0035264 19 10 0,000 4,213E-03 0,01006996 ! phagocytosis, engulfment GO:0006911 33 10 0,000 4,213E-03 0,01006012 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 4,213E-03 0,01005029 ! ruffle organization GO:0031529 17 10 0,000 4,213E-03 0,01004049 ! epithelial cell development GO:0002064 21 10 0,000 4,213E-03 0,0100307 ! lens development in camera-type eye GO:0002088 17 10 0,000 4,213E-03 0,01002094 ! retinoic acid metabolic process GO:0042573 14 10 0,000 4,213E-03 0,01001119 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 4,213E-03 0,01000146 ! positive regulation of translational initiation GO:0045948 12 10 0,000 4,213E-03 9,992E-03 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 4,213E-03 9,982E-03 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 4,213E-03 9,972E-03 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 4,213E-03 9,963E-03 ! motor axon guidance GO:0008045 22 10 0,000 4,213E-03 9,953E-03 ! copper ion homeostasis GO:0055070 13 10 0,000 4,213E-03 9,943E-03 ! regulation of bone resorption GO:0045124 25 10 0,000 4,213E-03 9,934E-03 ! protein heterooligomerization GO:0051291 17 10 0,000 4,213E-03 9,924E-03 ! regulation of gliogenesis GO:0014013 23 10 0,000 4,213E-03 9,915E-03 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 4,213E-03 9,905E-03 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 4,213E-03 9,896E-03 ! segment specification GO:0007379 15 10 0,000 4,213E-03 9,886E-03 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 4,213E-03 9,877E-03 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 4,213E-03 9,867E-03 ! blastoderm segmentation GO:0007350 19 10 0,000 4,213E-03 9,858E-03 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 4,213E-03 9,848E-03 ! response to dsRNA GO:0043331 23 10 0,000 4,213E-03 9,839E-03 ! DNA ligation GO:0006266 18 10 0,000 4,213E-03 9,83E-03 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 4,213E-03 9,82E-03 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 4,213E-03 9,811E-03 ! melanosome localization GO:0032400 16 10 0,000 4,213E-03 9,801E-03 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 4,213E-03 9,792E-03 ! regulation of B cell differentiation GO:0045577 24 10 0,000 4,213E-03 9,783E-03 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 4,213E-03 9,774E-03 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 4,213E-03 9,764E-03 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 4,213E-03 9,755E-03 ! induction of an organ GO:0001759 17 10 0,000 4,213E-03 9,746E-03 ! leukocyte activation during immune response GO:0002366 15 10 0,000 4,213E-03 9,737E-03 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 4,213E-03 9,727E-03 ! protein sumoylation GO:0016925 17 10 0,000 4,213E-03 9,718E-03 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 4,213E-03 9,709E-03 ! hindbrain morphogenesis GO:0021575 19 10 0,000 4,213E-03 9,7E-03 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 4,213E-03 9,691E-03 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 4,213E-03 9,682E-03 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 4,213E-03 9,672E-03 ! salivary gland development GO:0007431 28 10 0,000 4,213E-03 9,663E-03 ! ubiquinone metabolic process GO:0006743 17 10 0,000 4,213E-03 9,654E-03 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 4,213E-03 9,645E-03 ! midbrain development GO:0030901 14 10 0,000 4,213E-03 9,636E-03 ! musculoskeletal movement GO:0050881 16 10 0,000 4,213E-03 9,627E-03 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 4,213E-03 9,618E-03 ! methionine biosynthetic process GO:0009086 21 10 0,000 4,213E-03 9,609E-03 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 4,213E-03 9,6E-03 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 4,213E-03 9,591E-03 ! quaternary ammonium group transport GO:0015697 22 10 0,000 4,213E-03 9,582E-03 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 4,213E-03 9,573E-03 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 4,213E-03 9,565E-03 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 4,213E-03 9,556E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 4,213E-03 9,547E-03 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 4,213E-03 9,538E-03 ! establishment of pigment granule localization GO:0051905 18 10 0,000 4,213E-03 9,529E-03 ! blastocyst formation GO:0001825 18 10 0,000 4,213E-03 9,52E-03 ! regulation of fibrinolysis GO:0051917 20 10 0,000 4,213E-03 9,512E-03 ! cerebellar cortex development GO:0021695 16 10 0,000 4,213E-03 9,503E-03 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 4,213E-03 9,494E-03 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 4,213E-03 9,485E-03 ! response to nicotine GO:0035094 20 10 0,000 4,213E-03 9,477E-03 ! negative regulation of immune effector process GO:0002698 23 10 0,000 4,213E-03 9,468E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 4,213E-03 9,459E-03 ! negative regulation of muscle development GO:0048635 27 11 0,000 4,633E-03 0,01039341 ! respiratory burst GO:0045730 17 11 0,000 4,633E-03 0,01038387 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 4,633E-03 0,01037436 ! neuron fate specification GO:0048665 18 11 0,000 4,633E-03 0,01036486 ! telencephalon cell migration GO:0022029 23 11 0,000 4,633E-03 0,01035537 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 4,633E-03 0,01034591 ! thyroid gland development GO:0030878 26 11 0,000 4,633E-03 0,01033646 ! synapsis GO:0007129 14 11 0,000 4,633E-03 0,01032703 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 4,633E-03 0,01031761 ! Golgi vesicle budding GO:0048194 26 11 0,000 4,633E-03 0,01030822 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 4,633E-03 0,01029884 ! response to pain GO:0048265 27 11 0,000 4,633E-03 0,01028947 ! detection of mechanical stimulus GO:0050982 22 11 0,000 4,633E-03 0,01028013 ! blood vessel remodeling GO:0001974 30 11 0,000 4,633E-03 0,0102708 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 4,633E-03 0,01026149 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 4,633E-03 0,01025219 ! bone resorption GO:0045453 16 11 0,000 4,633E-03 0,01024292 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 4,633E-03 0,01023365 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 4,633E-03 0,01022441 ! negative regulation of proteolysis GO:0045861 25 11 0,000 4,633E-03 0,01021518 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 4,633E-03 0,01020597 ! melanocyte differentiation GO:0030318 20 11 0,000 4,633E-03 0,01019678 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 4,633E-03 0,0101876 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 4,633E-03 0,01017844 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 4,633E-03 0,01016929 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 4,633E-03 0,01016016 ! regulation of intracellular pH GO:0051453 21 11 0,000 4,633E-03 0,01015105 ! substrate-bound cell migration GO:0006929 14 11 0,000 4,633E-03 0,01014196 ! adult heart development GO:0007512 16 11 0,000 4,633E-03 0,01013288 ! chondrocyte differentiation GO:0002062 27 11 0,000 4,633E-03 0,01012381 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 4,633E-03 0,01011477 ! macroautophagy GO:0016236 19 11 0,000 4,633E-03 0,01010573 ! temperature homeostasis GO:0001659 18 11 0,000 4,633E-03 0,01009672 ! behavioral fear response GO:0001662 27 11 0,000 4,633E-03 0,01008772 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 4,633E-03 0,01007874 ! negative regulation of ossification GO:0030279 27 11 0,000 4,633E-03 0,01006977 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 4,633E-03 0,01006082 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 4,633E-03 0,01005188 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 4,633E-03 0,01004297 ! alpha-beta T cell activation GO:0046631 26 11 0,000 4,633E-03 0,01003406 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 4,633E-03 0,01002517 ! regulation of organ growth GO:0046620 14 11 0,000 4,633E-03 0,0100163 ! pigment granule localization GO:0051875 20 11 0,000 4,633E-03 0,01000745 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 4,633E-03 9,999E-03 ! vasoconstriction GO:0042310 20 11 0,000 4,633E-03 9,99E-03 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 4,633E-03 9,981E-03 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 4,633E-03 9,972E-03 ! embryonic axis specification GO:0000578 19 11 0,000 4,633E-03 9,963E-03 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 4,633E-03 9,955E-03 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 4,633E-03 9,946E-03 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 4,633E-03 9,937E-03 ! nitric oxide metabolic process GO:0046209 17 11 0,000 4,633E-03 9,928E-03 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 4,633E-03 9,92E-03 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 4,633E-03 9,911E-03 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 4,633E-03 9,902E-03 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 4,633E-03 9,894E-03 ! prophase GO:0051324 17 11 0,000 4,633E-03 9,885E-03 ! neuroblast proliferation GO:0007405 25 11 0,000 4,633E-03 9,876E-03 ! nucleosome positioning GO:0016584 15 11 0,000 4,633E-03 9,868E-03 ! regulation of isotype switching GO:0045191 24 11 0,000 4,633E-03 9,859E-03 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 4,633E-03 9,851E-03 ! negative regulation of neurological system process GO:0031645 21 11 0,000 4,633E-03 9,842E-03 ! apical protein localization GO:0045176 18 11 0,000 4,633E-03 9,834E-03 ! acid secretion GO:0046717 20 11 0,000 4,633E-03 9,825E-03 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 4,633E-03 9,816E-03 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 4,633E-03 9,808E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 4,633E-03 9,799E-03 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 4,633E-03 9,791E-03 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 4,633E-03 9,783E-03 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 4,633E-03 9,774E-03 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 4,633E-03 9,766E-03 ! cholesterol efflux GO:0033344 21 11 0,000 4,633E-03 9,757E-03 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 4,633E-03 9,749E-03 ! oocyte development GO:0048599 20 11 0,000 4,633E-03 9,74E-03 ! negative regulation of glucose import GO:0046325 18 11 0,000 4,633E-03 9,732E-03 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 4,633E-03 9,724E-03 ! embryonic gut development GO:0048566 19 11 0,000 4,633E-03 9,715E-03 ! regulation of organic acid transport GO:0032890 19 11 0,000 4,633E-03 9,707E-03 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 4,633E-03 9,699E-03 ! activation of innate immune response GO:0002218 16 11 0,000 4,633E-03 9,69E-03 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 4,633E-03 9,682E-03 ! cardiac cell differentiation GO:0035051 36 11 0,000 4,633E-03 9,674E-03 ! lysogeny GO:0030069 22 11 0,000 4,633E-03 9,666E-03 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 4,633E-03 9,657E-03 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 4,633E-03 9,649E-03 ! sequestering of metal ion GO:0051238 15 11 0,000 4,633E-03 9,641E-03 ! regulation of embryonic development GO:0045995 35 11 0,000 4,633E-03 9,633E-03 ! nucleus localization GO:0051647 22 11 0,000 4,633E-03 9,625E-03 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 5,053E-03 0,01048848 ! positive regulation of blood pressure GO:0045777 18 12 0,000 5,053E-03 0,01047957 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 5,053E-03 0,01047069 ! virus-host interaction GO:0019048 30 12 0,000 5,053E-03 0,01046181 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 5,053E-03 0,01045295 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 5,053E-03 0,01044411 ! protein complex disassembly GO:0043241 28 12 0,000 5,053E-03 0,01043528 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 5,053E-03 0,01042647 ! regulation of cell projection assembly GO:0060491 33 12 0,000 5,053E-03 0,01041767 ! hippocampus development GO:0021766 29 12 0,000 5,053E-03 0,01040889 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 5,053E-03 0,01040012 ! cytokine biosynthetic process GO:0042089 23 12 0,000 5,053E-03 0,01039136 ! T cell proliferation GO:0042098 32 12 0,000 5,053E-03 0,01038262 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 5,053E-03 0,0103739 ! regulation of exit from mitosis GO:0007096 19 12 0,000 5,053E-03 0,01036519 ! ventral spinal cord development GO:0021517 25 12 0,000 5,053E-03 0,01035649 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 5,053E-03 0,01034781 ! drug transport GO:0015893 16 12 0,000 5,053E-03 0,01033914 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 5,053E-03 0,01033049 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 5,053E-03 0,01032186 ! tyrosine metabolic process GO:0006570 19 12 0,000 5,053E-03 0,01031323 ! polyamine metabolic process GO:0006595 18 12 0,000 5,053E-03 0,01030462 ! focal adhesion formation GO:0048041 37 12 0,000 5,053E-03 0,01029603 ! mitotic spindle organization GO:0007052 23 12 0,000 5,053E-03 0,01028745 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 5,053E-03 0,01027888 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 5,053E-03 0,01027033 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 5,053E-03 0,01026179 ! lipid digestion GO:0044241 21 12 0,000 5,053E-03 0,01025327 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 5,053E-03 0,01024476 ! entry into host cell GO:0030260 34 12 0,000 5,053E-03 0,01023627 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 5,053E-03 0,01022779 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 5,053E-03 0,01021932 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 5,053E-03 0,01021087 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 5,053E-03 0,01020243 ! protein targeting to peroxisome GO:0006625 27 12 0,000 5,053E-03 0,010194 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 5,053E-03 0,01018559 ! regulation of phagocytosis GO:0050764 17 12 0,000 5,053E-03 0,0101772 ! snRNA metabolic process GO:0016073 30 12 0,000 5,053E-03 0,01016881 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 5,053E-03 0,01016044 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 5,053E-03 0,01015209 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 5,053E-03 0,01014375 ! cranial nerve development GO:0021545 23 12 0,000 5,053E-03 0,01013542 ! fucose catabolic process GO:0019317 25 12 0,000 5,053E-03 0,0101271 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 5,053E-03 0,0101188 ! histone acetylation GO:0016573 27 12 0,000 5,053E-03 0,01011052 ! mRNA polyadenylation GO:0006378 24 12 0,000 5,053E-03 0,01010224 ! autonomic nervous system development GO:0048483 24 12 0,000 5,053E-03 0,01009398 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 5,053E-03 0,01008573 ! zymogen activation GO:0031638 18 12 0,000 5,053E-03 0,0100775 ! peptidyl-lysine modification GO:0018205 21 12 0,000 5,053E-03 0,01006928 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 5,053E-03 0,01006107 ! glutathione biosynthetic process GO:0006750 15 12 0,000 5,053E-03 0,01005288 ! regulation of leukocyte migration GO:0002685 29 12 0,000 5,053E-03 0,0100447 ! oocyte differentiation GO:0009994 21 12 0,000 5,053E-03 0,01003654 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 5,053E-03 0,01002838 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 5,053E-03 0,01002024 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 5,053E-03 0,01001212 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 5,053E-03 0,010004 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 5,053E-03 9,996E-03 ! defense response to fungus GO:0050832 15 12 0,000 5,053E-03 9,988E-03 ! developmental induction GO:0031128 22 12 0,000 5,053E-03 9,98E-03 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 5,053E-03 9,972E-03 ! lamellipodium assembly GO:0030032 24 12 0,000 5,053E-03 9,964E-03 ! response to cold GO:0009409 17 12 0,000 5,053E-03 9,956E-03 ! establishment of cell polarity GO:0030010 21 12 0,000 5,053E-03 9,948E-03 ! regulation of synapse organization GO:0050807 18 12 0,000 5,053E-03 9,94E-03 ! localization within membrane GO:0051668 26 12 0,000 5,053E-03 9,932E-03 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 5,473E-03 0,01074843 ! cGMP metabolic process GO:0046068 18 13 0,000 5,473E-03 0,0107398 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 5,473E-03 0,01073118 ! regulation of chemokine production GO:0032642 18 13 0,000 5,473E-03 0,01072258 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 5,473E-03 0,01071398 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 5,473E-03 0,01070541 ! peroxisomal transport GO:0043574 28 13 0,000 5,473E-03 0,01069684 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 5,473E-03 0,01068829 ! cartilage condensation GO:0001502 22 13 0,000 5,473E-03 0,01067975 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 5,473E-03 0,01067123 ! organelle fusion GO:0048284 36 13 0,000 5,473E-03 0,01066272 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 5,473E-03 0,01065422 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 5,473E-03 0,01064574 ! pseudouridine synthesis GO:0001522 19 13 0,000 5,473E-03 0,01063727 ! endocrine pancreas development GO:0031018 25 13 0,000 5,473E-03 0,01062882 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 5,473E-03 0,01062037 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 5,473E-03 0,01061195 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 5,473E-03 0,01060353 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 5,473E-03 0,01059513 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 5,473E-03 0,01058674 ! methionine metabolic process GO:0006555 31 13 0,000 5,473E-03 0,01057836 ! plasma membrane organization GO:0007009 27 13 0,000 5,473E-03 0,01057 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 5,473E-03 0,01056165 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 5,473E-03 0,01055332 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 5,473E-03 0,01054499 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 5,473E-03 0,01053668 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 5,473E-03 0,01052839 ! cytokine metabolic process GO:0042107 24 13 0,000 5,473E-03 0,0105201 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 5,473E-03 0,01051183 ! exocrine system development GO:0035272 34 13 0,000 5,473E-03 0,01050358 ! asymmetric protein localization GO:0008105 24 13 0,000 5,473E-03 0,01049533 ! membrane protein proteolysis GO:0033619 33 13 0,000 5,473E-03 0,0104871 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 5,473E-03 0,01047888 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 5,473E-03 0,01047067 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 5,473E-03 0,01046248 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 5,473E-03 0,0104543 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 5,473E-03 0,01044613 ! protein homotetramerization GO:0051289 24 13 0,000 5,473E-03 0,01043798 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 5,473E-03 0,01042984 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 5,473E-03 0,01042171 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 5,473E-03 0,01041359 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 5,473E-03 0,01040549 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 5,473E-03 0,0103974 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 5,473E-03 0,01038932 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 5,473E-03 0,01038125 ! chromatin silencing GO:0006342 29 13 0,000 5,473E-03 0,0103732 ! gland morphogenesis GO:0022612 31 13 0,000 5,473E-03 0,01036516 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 5,473E-03 0,01035713 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 5,473E-03 0,01034911 ! regulation of epidermis development GO:0045682 19 13 0,000 5,473E-03 0,01034111 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 5,473E-03 0,01033312 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 5,473E-03 0,01032514 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 5,473E-03 0,01031717 ! spleen development GO:0048536 24 13 0,000 5,473E-03 0,01030921 ! regulation of mRNA stability GO:0043488 32 13 0,000 5,473E-03 0,01030127 ! digestive tract morphogenesis GO:0048546 31 13 0,000 5,473E-03 0,01029334 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 5,473E-03 0,01028542 ! anterior/posterior axis specification GO:0009948 22 13 0,000 5,473E-03 0,01027752 ! regulation of RNA splicing GO:0043484 22 13 0,000 5,473E-03 0,01026962 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 5,473E-03 0,01026174 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 5,473E-03 0,01025387 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 5,473E-03 0,01024602 ! mRNA 3'-end processing GO:0031124 25 13 0,000 5,473E-03 0,01023817 ! insulin secretion GO:0030073 24 13 0,000 5,473E-03 0,01023034 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 5,473E-03 0,01022252 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 5,473E-03 0,01021471 ! acrosome reaction GO:0007340 19 13 0,000 5,473E-03 0,01020691 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 5,473E-03 0,01019912 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 5,473E-03 0,01019135 ! rRNA transcription GO:0009303 28 14 0,000 5,893E-03 0,01096478 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 5,893E-03 0,01095644 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 5,893E-03 0,01094811 ! water transport GO:0006833 21 14 0,000 5,893E-03 0,01093979 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 5,893E-03 0,01093148 ! non-recombinational repair GO:0000726 29 14 0,000 5,893E-03 0,01092319 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 5,893E-03 0,0109149 ! retina development in camera-type eye GO:0060041 28 14 0,000 5,893E-03 0,01090664 ! hair follicle morphogenesis GO:0031069 27 14 0,000 5,893E-03 0,01089838 ! RNA polyadenylation GO:0043631 32 14 0,000 5,893E-03 0,01089014 ! lipid localization GO:0010876 32 14 0,000 5,893E-03 0,0108819 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 5,893E-03 0,01087369 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 5,893E-03 0,01086548 ! regulated secretory pathway GO:0045055 24 14 0,000 5,893E-03 0,01085728 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 5,893E-03 0,0108491 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 5,893E-03 0,01084093 ! arginine metabolic process GO:0006525 21 14 0,000 5,893E-03 0,01083278 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 5,893E-03 0,01082463 ! cell-cell junction assembly GO:0007043 32 14 0,000 5,893E-03 0,0108165 ! regulation of heart rate GO:0002027 25 14 0,000 5,893E-03 0,01080838 ! fear response GO:0042596 34 14 0,000 5,893E-03 0,01080027 ! organic alcohol transport GO:0015850 29 14 0,000 5,893E-03 0,01079217 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 5,893E-03 0,01078409 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 5,893E-03 0,01077602 ! neutral amino acid transport GO:0015804 28 14 0,000 5,893E-03 0,01076796 ! bone mineralization GO:0030282 18 14 0,000 5,893E-03 0,01075991 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 5,893E-03 0,01075187 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 5,893E-03 0,01074385 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 5,893E-03 0,01073584 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 5,893E-03 0,01072784 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 5,893E-03 0,01071985 ! regulation of cellular pH GO:0030641 27 14 0,000 5,893E-03 0,01071187 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 5,893E-03 0,01070391 ! ribosome assembly GO:0042255 18 14 0,000 5,893E-03 0,01069596 ! cerebellum development GO:0021549 23 14 0,000 5,893E-03 0,01068802 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 5,893E-03 0,01068009 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 5,893E-03 0,01067217 ! negative regulation of protein secretion GO:0050709 30 14 0,000 5,893E-03 0,01066427 ! response to gamma radiation GO:0010332 30 14 0,000 5,893E-03 0,01065637 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 5,893E-03 0,01064849 ! NADP metabolic process GO:0006739 24 14 0,000 5,893E-03 0,01064062 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 5,893E-03 0,01063276 ! oxygen transport GO:0015671 22 14 0,000 5,893E-03 0,01062491 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 5,893E-03 0,01061708 ! male genitalia development GO:0030539 26 14 0,000 5,893E-03 0,01060926 ! regulation of RNA stability GO:0043487 33 14 0,000 5,893E-03 0,01060144 ! regulation of axon extension GO:0030516 43 14 0,000 5,893E-03 0,01059364 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 5,893E-03 0,01058585 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 5,893E-03 0,01057807 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 6,313E-03 0,0113231 ! lactation GO:0007595 30 15 0,000 6,313E-03 0,01131479 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 6,313E-03 0,0113065 ! reproductive cellular process GO:0048610 22 15 0,000 6,313E-03 0,01129821 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 6,313E-03 0,01128994 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 6,313E-03 0,01128169 ! superoxide anion generation GO:0042554 22 15 0,000 6,313E-03 0,01127344 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 6,313E-03 0,0112652 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 6,313E-03 0,01125698 ! phospholipid catabolic process GO:0009395 27 15 0,000 6,313E-03 0,01124877 ! copper ion transport GO:0006825 22 15 0,000 6,313E-03 0,01124057 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 6,313E-03 0,01123238 ! cardiac muscle contraction GO:0060048 28 15 0,000 6,313E-03 0,01122421 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 6,313E-03 0,01121605 ! sulfate transport GO:0008272 27 15 0,000 6,313E-03 0,01120789 ! response to cAMP GO:0051591 25 15 0,000 6,313E-03 0,01119976 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 6,313E-03 0,01119163 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 6,313E-03 0,01118351 ! regulation of mRNA processing GO:0050684 26 15 0,000 6,313E-03 0,01117541 ! response to hexose stimulus GO:0009746 25 15 0,000 6,313E-03 0,01116732 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 6,313E-03 0,01115924 ! glycoprotein catabolic process GO:0006516 33 15 0,000 6,313E-03 0,01115117 ! vesicle coating GO:0006901 38 15 0,000 6,313E-03 0,01114311 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 6,313E-03 0,01113506 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 6,313E-03 0,01112703 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 6,313E-03 0,01111901 ! regulation of exocytosis GO:0017157 26 15 0,000 6,313E-03 0,011111 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 6,313E-03 0,011103 ! G1/S transition checkpoint GO:0031575 37 15 0,000 6,313E-03 0,01109501 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 6,313E-03 0,01108703 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 6,313E-03 0,01107907 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 6,313E-03 0,01107112 ! regulation of vasodilation GO:0042312 27 15 0,000 6,313E-03 0,01106317 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 6,313E-03 0,01105524 ! histone deacetylation GO:0016575 24 15 0,000 6,313E-03 0,01104732 ! water homeostasis GO:0030104 28 15 0,000 6,313E-03 0,01103942 ! cofactor transport GO:0051181 30 15 0,000 6,313E-03 0,01103152 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 6,313E-03 0,01102363 ! muscle maintenance GO:0046716 26 15 0,000 6,313E-03 0,01101576 ! protein-chromophore linkage GO:0018298 25 15 0,000 6,313E-03 0,0110079 ! intestinal absorption GO:0050892 31 15 0,000 6,313E-03 0,01100005 ! dopamine metabolic process GO:0042417 35 15 0,000 6,313E-03 0,0109922 ! cAMP biosynthetic process GO:0006171 25 15 0,000 6,313E-03 0,01098438 ! heme biosynthetic process GO:0006783 33 15 0,000 6,313E-03 0,01097656 ! cell killing GO:0001906 32 15 0,000 6,313E-03 0,01096875 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 6,313E-03 0,01096095 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 6,313E-03 0,01095317 ! L-fucose metabolic process GO:0042354 33 15 0,000 6,313E-03 0,0109454 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 6,313E-03 0,01093763 ! actin filament polymerization GO:0030041 27 15 0,000 6,313E-03 0,01092988 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 6,313E-03 0,01092214 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 6,732E-03 0,01163975 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 6,732E-03 0,01163152 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 6,732E-03 0,0116233 ! dicarboxylic acid transport GO:0006835 47 16 0,000 6,732E-03 0,01161509 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 6,732E-03 0,01160689 ! bone remodeling GO:0046849 28 16 0,000 6,732E-03 0,0115987 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 6,732E-03 0,01159053 ! heterophilic cell adhesion GO:0007157 43 16 0,000 6,732E-03 0,01158237 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 6,732E-03 0,01157422 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 6,732E-03 0,01156608 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 6,732E-03 0,01155795 ! positive regulation of ion transport GO:0043270 23 16 0,000 6,732E-03 0,01154983 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 6,732E-03 0,01154173 ! startle response GO:0001964 28 16 0,000 6,732E-03 0,01153363 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 6,732E-03 0,01152555 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 6,732E-03 0,01151748 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 6,732E-03 0,01150942 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 6,732E-03 0,01150137 ! protein polyubiquitination GO:0000209 41 16 0,000 6,732E-03 0,01149334 ! glutamate metabolic process GO:0006536 25 16 0,000 6,732E-03 0,01148531 ! pituitary gland development GO:0021983 30 16 0,000 6,732E-03 0,01147729 ! response to osmotic stress GO:0006970 27 16 0,000 6,732E-03 0,01146929 ! lysosomal transport GO:0007041 31 16 0,000 6,732E-03 0,0114613 ! fructose metabolic process GO:0006000 25 16 0,000 6,732E-03 0,01145332 ! L-amino acid transport GO:0015807 33 16 0,000 6,732E-03 0,01144535 ! stem cell development GO:0048864 46 16 0,000 6,732E-03 0,01143739 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 6,732E-03 0,01142944 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 6,732E-03 0,0114215 ! intermediate filament-based process GO:0045103 36 16 0,000 6,732E-03 0,01141358 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 6,732E-03 0,01140566 ! negative regulation of immune response GO:0050777 38 16 0,000 6,732E-03 0,01139776 ! axon cargo transport GO:0008088 46 16 0,000 6,732E-03 0,01138986 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 6,732E-03 0,01138198 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 6,732E-03 0,01137411 ! DNA replication initiation GO:0006270 28 16 0,000 6,732E-03 0,01136625 ! neuron recognition GO:0008038 40 16 0,000 6,732E-03 0,0113584 ! mRNA splice site selection GO:0006376 44 16 0,000 6,732E-03 0,01135056 ! tissue regeneration GO:0042246 27 16 0,000 6,732E-03 0,01134273 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 6,732E-03 0,01133492 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 6,732E-03 0,01132711 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 6,732E-03 0,01131931 ! biomineral formation GO:0031214 22 16 0,000 6,732E-03 0,01131153 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 6,732E-03 0,01130375 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 6,732E-03 0,01129599 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 6,732E-03 0,01128824 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 6,732E-03 0,0112805 ! regulation of ATPase activity GO:0043462 26 16 0,000 6,732E-03 0,01127276 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 6,732E-03 0,01126504 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 6,732E-03 0,01125733 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 6,732E-03 0,01124963 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 6,732E-03 0,01124194 ! peptide hormone processing GO:0016486 27 16 0,000 6,732E-03 0,01123426 ! positive regulation of cell killing GO:0031343 36 17 0,000 7,152E-03 0,01192591 ! metencephalon development GO:0022037 32 17 0,000 7,152E-03 0,01191778 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 7,152E-03 0,01190965 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 7,152E-03 0,01190154 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 7,152E-03 0,01189344 ! signal complex assembly GO:0007172 47 17 0,000 7,152E-03 0,01188535 ! filopodium assembly GO:0046847 42 17 0,000 7,152E-03 0,01187727 ! endothelial cell migration GO:0043542 31 17 0,000 7,152E-03 0,0118692 ! gene silencing by RNA GO:0031047 38 17 0,000 7,152E-03 0,01186114 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 7,152E-03 0,01185309 ! glial cell development GO:0021782 28 17 0,000 7,152E-03 0,01184506 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 7,152E-03 0,01183703 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 7,152E-03 0,01182902 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 7,152E-03 0,01182101 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 7,152E-03 0,01181302 ! myoblast differentiation GO:0045445 50 17 0,000 7,152E-03 0,01180504 ! activation of MAPKK activity GO:0000186 43 17 0,000 7,152E-03 0,01179707 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 7,152E-03 0,01178911 ! cardiac muscle tissue development GO:0048738 34 17 0,000 7,152E-03 0,01178116 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 7,152E-03 0,01177322 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 7,152E-03 0,01176529 ! complement activation, alternative pathway GO:0006957 19 17 0,000 7,152E-03 0,01175738 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 7,152E-03 0,01174947 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 7,152E-03 0,01174157 ! membrane budding GO:0006900 42 17 0,000 7,152E-03 0,01173369 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 7,152E-03 0,01172581 ! regulation of protein binding GO:0043393 33 17 0,000 7,152E-03 0,01171795 ! nucleobase metabolic process GO:0009112 43 17 0,000 7,152E-03 0,01171009 ! DNA unwinding during replication GO:0006268 26 17 0,000 7,152E-03 0,01170225 ! genitalia development GO:0048806 32 17 0,000 7,152E-03 0,01169442 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 7,152E-03 0,01168659 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 7,152E-03 0,01167878 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 7,152E-03 0,01167098 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 7,152E-03 0,01166319 ! neutrophil chemotaxis GO:0030593 29 17 0,000 7,152E-03 0,01165541 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 7,152E-03 0,01164764 ! steroid catabolic process GO:0006706 34 17 0,000 7,152E-03 0,01163988 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 7,152E-03 0,01163213 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 7,152E-03 0,01162439 ! gas transport GO:0015669 26 17 0,000 7,152E-03 0,01161666 ! organic cation transport GO:0015695 32 17 0,000 7,152E-03 0,01160894 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 7,152E-03 0,01160123 ! RNA 3'-end processing GO:0031123 37 17 0,000 7,152E-03 0,01159354 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 7,152E-03 0,01158585 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 7,571E-03 0,01225683 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 7,571E-03 0,01224871 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 7,571E-03 0,0122406 ! limbic system development GO:0021761 40 18 0,000 7,571E-03 0,01223251 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 7,571E-03 0,01222442 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 7,571E-03 0,01221635 ! adult walking behavior GO:0007628 36 18 0,000 7,571E-03 0,01220828 ! patterning of blood vessels GO:0001569 43 18 0,000 7,571E-03 0,01220023 ! heart looping GO:0001947 34 18 0,000 7,571E-03 0,01219219 ! ciliary or flagellar motility GO:0001539 32 18 0,000 7,571E-03 0,01218416 ! regulation of viral genome replication GO:0045069 30 18 0,000 7,571E-03 0,01217614 ! centrosome cycle GO:0007098 26 18 0,000 7,571E-03 0,01216813 ! regulation of defense response to virus GO:0050688 35 18 0,000 7,571E-03 0,01216013 ! epidermis morphogenesis GO:0048730 43 18 0,000 7,571E-03 0,01215214 ! glycine metabolic process GO:0006544 30 18 0,000 7,571E-03 0,01214416 ! glutamine metabolic process GO:0006541 29 18 0,000 7,571E-03 0,01213619 ! response to retinoic acid GO:0032526 31 18 0,000 7,571E-03 0,01212823 ! cell-substrate junction assembly GO:0007044 56 18 0,000 7,571E-03 0,01212028 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 7,571E-03 0,01211235 ! DNA integration GO:0015074 32 18 0,000 7,571E-03 0,01210442 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 7,571E-03 0,0120965 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 7,571E-03 0,0120886 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 7,571E-03 0,0120807 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 7,571E-03 0,01207281 ! neural crest cell migration GO:0001755 41 18 0,000 7,571E-03 0,01206494 ! long-chain fatty acid transport GO:0015909 32 18 0,000 7,571E-03 0,01205707 ! sphingolipid catabolic process GO:0030149 32 18 0,000 7,571E-03 0,01204922 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 7,571E-03 0,01204137 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 7,571E-03 0,01203354 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 7,571E-03 0,01202572 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 7,571E-03 0,0120179 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 7,571E-03 0,0120101 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 7,571E-03 0,0120023 ! detection of bacterium GO:0016045 22 18 0,000 7,571E-03 0,01199452 ! nerve development GO:0021675 34 18 0,000 7,571E-03 0,01198675 ! defense response to virus GO:0051607 43 18 0,000 7,571E-03 0,01197898 ! microspike assembly GO:0030035 46 18 0,000 7,571E-03 0,01197123 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 7,571E-03 0,01196349 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 7,571E-03 0,01195575 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 7,99E-03 0,01260933 ! positive regulation of translation GO:0045727 31 19 0,000 7,99E-03 0,01260119 ! negative regulation of defense response GO:0031348 27 19 0,000 7,99E-03 0,01259306 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 7,99E-03 0,01258494 ! neuron maturation GO:0042551 46 19 0,000 7,99E-03 0,01257683 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 7,99E-03 0,01256873 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 7,99E-03 0,01256064 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 7,99E-03 0,01255257 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 7,99E-03 0,0125445 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 7,99E-03 0,01253644 ! inositol metabolic process GO:0006020 33 19 0,000 7,99E-03 0,0125284 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 7,99E-03 0,01252036 ! memory GO:0007613 34 19 0,000 7,99E-03 0,01251233 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 7,99E-03 0,01250432 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 7,99E-03 0,01249631 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 7,99E-03 0,01248832 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 7,99E-03 0,01248033 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 7,99E-03 0,01247236 ! cerebral cortex development GO:0021987 40 19 0,000 7,99E-03 0,01246439 ! pigmentation during development GO:0048066 42 19 0,000 7,99E-03 0,01245644 ! response to vitamin A GO:0033189 32 19 0,000 7,99E-03 0,0124485 ! heme metabolic process GO:0042168 40 19 0,000 7,99E-03 0,01244056 ! neuromuscular junction development GO:0007528 43 19 0,000 7,99E-03 0,01243264 ! response to lipopolysaccharide GO:0032496 34 19 0,000 7,99E-03 0,01242472 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 7,99E-03 0,01241682 ! response to fungus GO:0009620 26 19 0,000 7,99E-03 0,01240893 ! peptide cross-linking GO:0018149 39 19 0,000 7,99E-03 0,01240104 ! protein export from nucleus GO:0006611 40 19 0,000 7,99E-03 0,01239317 ! heart process GO:0003015 32 19 0,000 7,99E-03 0,0123853 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 7,99E-03 0,01237745 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 7,99E-03 0,01236961 ! visual learning GO:0008542 38 19 0,000 7,99E-03 0,01236177 ! cellular pigmentation GO:0033059 37 19 0,000 7,99E-03 0,01235395 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 7,99E-03 0,01234614 ! peptide biosynthetic process GO:0043043 26 19 0,000 7,99E-03 0,01233833 ! vitamin transport GO:0051180 31 19 0,000 7,99E-03 0,01233054 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 7,99E-03 0,01232275 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 7,99E-03 0,01231498 ! proximal/distal pattern formation GO:0009954 33 19 0,000 7,99E-03 0,01230721 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 7,99E-03 0,01229946 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 7,99E-03 0,01229171 ! cilium assembly GO:0042384 38 19 0,000 7,99E-03 0,01228398 ! peptide hormone secretion GO:0030072 32 19 0,000 7,99E-03 0,01227625 ! protein secretion GO:0009306 45 20 0,000 8,409E-03 0,01291171 ! protein import into nucleus, docking GO:0000059 42 20 0,000 8,409E-03 0,0129036 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 8,409E-03 0,0128955 ! positive regulation of ossification GO:0045778 50 20 0,000 8,409E-03 0,01288741 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 8,409E-03 0,01287933 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 8,409E-03 0,01287126 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 8,409E-03 0,0128632 ! protein amino acid deacetylation GO:0006476 34 20 0,000 8,409E-03 0,01285515 ! protein amino acid acetylation GO:0006473 41 20 0,000 8,409E-03 0,01284711 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 8,409E-03 0,01283908 ! aminoglycan catabolic process GO:0006026 25 20 0,000 8,409E-03 0,01283106 ! response to vitamin GO:0033273 36 20 0,000 8,409E-03 0,01282305 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 8,409E-03 0,01281505 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 8,409E-03 0,01280706 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 8,409E-03 0,01279908 ! bile acid metabolic process GO:0008206 34 20 0,000 8,409E-03 0,01279111 ! response to alkaloid GO:0043279 38 20 0,000 8,409E-03 0,01278315 ! retinoid metabolic process GO:0001523 34 20 0,000 8,409E-03 0,0127752 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 8,409E-03 0,01276726 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 8,409E-03 0,01275933 ! DNA duplex unwinding GO:0032508 30 20 0,000 8,409E-03 0,01275141 GO:0032392|DNA geometric change, ! actin filament bundle formation GO:0051017 47 20 0,000 8,409E-03 0,0127435 ! body fluid secretion GO:0007589 33 20 0,000 8,409E-03 0,0127356 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 8,409E-03 0,01272771 ! peptide secretion GO:0002790 38 20 0,000 8,409E-03 0,01271983 ! behavioral interaction between organisms GO:0051705 47 20 0,000 8,409E-03 0,01271196 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 8,409E-03 0,0127041 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 8,409E-03 0,01269625 ! protein localization in mitochondrion GO:0070585 39 20 0,000 8,409E-03 0,0126884 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 8,409E-03 0,01268057 ! cell-cell junction organization GO:0045216 43 20 0,000 8,409E-03 0,01267275 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 8,409E-03 0,01266494 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 8,409E-03 0,01265713 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 8,409E-03 0,01264934 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 8,409E-03 0,01264155 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 8,409E-03 0,01263378 ! regulation of glucose import GO:0046324 30 20 0,000 8,409E-03 0,01262601 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 8,409E-03 0,01261826 ! negative regulation of T cell activation GO:0050868 41 20 0,000 8,409E-03 0,01261051 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 8,409E-03 0,01260278 ! negative regulation of translation GO:0017148 32 20 0,000 8,409E-03 0,01259505 ! negative regulation of coagulation GO:0050819 30 20 0,000 8,409E-03 0,01258733 ! regulation of cell killing GO:0031341 46 21 0,000 8,827E-03 0,01320601 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 8,827E-03 0,01319792 ! hormone secretion GO:0046879 39 21 0,000 8,827E-03 0,01318985 ! lipid phosphorylation GO:0046834 43 21 0,000 8,827E-03 0,01318179 ! cAMP metabolic process GO:0046058 41 21 0,000 8,827E-03 0,01317374 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 8,827E-03 0,01316569 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 8,827E-03 0,01315766 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 8,827E-03 0,01314964 ! ovarian follicle development GO:0001541 39 21 0,000 8,827E-03 0,01314163 ! smooth muscle contraction GO:0006939 48 21 0,000 8,827E-03 0,01313362 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 8,827E-03 0,01312563 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 8,827E-03 0,01311764 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 8,827E-03 0,01310967 ! plasma membrane fusion GO:0045026 33 21 0,000 8,827E-03 0,01310171 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 8,827E-03 0,01309375 ! prostaglandin metabolic process GO:0006693 43 21 0,000 8,827E-03 0,01308581 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 8,827E-03 0,01307787 ! sensory perception of pain GO:0019233 33 21 0,000 8,827E-03 0,01306994 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 8,827E-03 0,01306203 ! diencephalon development GO:0021536 36 21 0,000 8,827E-03 0,01305412 ! collagen fibril organization GO:0030199 62 21 0,000 8,827E-03 0,01304622 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 8,827E-03 0,01303834 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 8,827E-03 0,01303046 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 8,827E-03 0,01302259 ! vitamin A metabolic process GO:0006776 35 21 0,000 8,827E-03 0,01301473 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 8,827E-03 0,01300688 ! collagen catabolic process GO:0030574 29 21 0,000 8,827E-03 0,01299904 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 8,827E-03 0,01299121 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 8,827E-03 0,01298339 ! sperm-egg recognition GO:0035036 23 21 0,000 8,827E-03 0,01297558 ! actin filament-based movement GO:0030048 47 21 0,000 8,827E-03 0,01296777 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 8,827E-03 0,01295998 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 9,246E-03 0,0135663 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 9,246E-03 0,01355816 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 9,246E-03 0,01355002 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 9,246E-03 0,0135419 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 9,246E-03 0,01353378 ! microtubule-based transport GO:0010970 59 22 0,000 9,246E-03 0,01352568 ! hindlimb morphogenesis GO:0035137 47 22 0,000 9,246E-03 0,01351759 ! glutamate signaling pathway GO:0007215 48 22 0,000 9,246E-03 0,0135095 ! inactivation of MAPK activity GO:0000188 45 22 0,000 9,246E-03 0,01350143 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 9,246E-03 0,01349336 ! cellular response to starvation GO:0009267 37 22 0,000 9,246E-03 0,01348531 ! vacuolar transport GO:0007034 41 22 0,000 9,246E-03 0,01347726 ! central nervous system neuron development GO:0021954 47 22 0,000 9,246E-03 0,01346922 ! fucose metabolic process GO:0006004 44 22 0,000 9,246E-03 0,0134612 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 9,246E-03 0,01345318 ! D-ribose metabolic process GO:0006014 36 22 0,000 9,246E-03 0,01344517 ! apoptotic nuclear changes GO:0030262 34 22 0,000 9,246E-03 0,01343717 ! ureteric bud development GO:0001657 50 22 0,000 9,246E-03 0,01342918 ! cell aging GO:0007569 48 22 0,000 9,246E-03 0,0134212 ! stem cell differentiation GO:0048863 57 22 0,000 9,246E-03 0,01341323 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 9,246E-03 0,01340527 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 9,246E-03 0,01339732 ! cytolysis GO:0019835 27 22 0,000 9,246E-03 0,01338938 ! renal system process GO:0003014 42 22 0,000 9,246E-03 0,01338145 ! vasodilation GO:0042311 40 22 0,000 9,246E-03 0,01337353 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 9,246E-03 0,01336561 ! positive regulation of locomotion GO:0040017 44 22 0,000 9,246E-03 0,01335771 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 9,246E-03 0,01334981 ! detection of chemical stimulus GO:0009593 42 22 0,000 9,246E-03 0,01334193 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 9,246E-03 0,01333405 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 9,246E-03 0,01332619 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 9,246E-03 0,01331833 ! regulation of cytokine secretion GO:0050707 41 22 0,000 9,246E-03 0,01331048 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 9,246E-03 0,01330264 ! sarcomere organization GO:0045214 32 22 0,000 9,246E-03 0,01329481 ! response to cytokine stimulus GO:0034097 69 22 0,000 9,246E-03 0,01328699 ! activation of JUN kinase activity GO:0007257 47 22 0,000 9,246E-03 0,01327918 ! terpenoid metabolic process GO:0006721 40 22 0,000 9,246E-03 0,01327138 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 9,246E-03 0,01326359 ! gut development GO:0048565 44 22 0,000 9,246E-03 0,0132558 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 9,246E-03 0,01324803 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 9,246E-03 0,01324026 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 9,246E-03 0,01323251 ! protein stabilization GO:0050821 41 22 0,000 9,246E-03 0,01322476 ! positive regulation of DNA replication GO:0045740 44 23 0,000 9,664E-03 0,01381507 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 9,664E-03 0,013807 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 9,664E-03 0,01379893 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 9,664E-03 0,01379087 ! gluconeogenesis GO:0006094 38 23 0,000 9,664E-03 0,01378282 ! glycerol metabolic process GO:0006071 40 23 0,000 9,664E-03 0,01377477 ! viral genome replication GO:0019079 44 23 0,000 9,664E-03 0,01376674 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 9,664E-03 0,01375872 ! glucosamine metabolic process GO:0006041 31 23 0,000 9,664E-03 0,01375071 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 9,664E-03 0,0137427 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 9,664E-03 0,01373471 ! regeneration GO:0031099 42 23 0,000 9,664E-03 0,01372672 ! axis specification GO:0009798 43 23 0,000 9,664E-03 0,01371875 ! visual behavior GO:0007632 46 23 0,000 9,664E-03 0,01371078 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 9,664E-03 0,01370282 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 9,664E-03 0,01369487 ! response to ethanol GO:0045471 47 23 0,000 9,664E-03 0,01368693 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 9,664E-03 0,01367901 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 9,664E-03 0,01367108 ! peroxisome organization GO:0007031 43 23 0,000 9,664E-03 0,01366317 ! lysosome organization GO:0007040 47 23 0,000 9,664E-03 0,01365527 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 9,664E-03 0,01364738 ! vesicle targeting GO:0006903 49 23 0,000 9,664E-03 0,01363949 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 9,664E-03 0,01363162 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 9,664E-03 0,01362375 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 9,664E-03 0,0136159 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 9,664E-03 0,01360805 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 9,664E-03 0,01360021 ! DNA modification GO:0006304 36 23 0,000 9,664E-03 0,01359238 ! fatty acid transport GO:0015908 47 23 0,000 9,664E-03 0,01358456 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 9,664E-03 0,01357675 ! regulation of bone mineralization GO:0030500 54 23 0,000 9,664E-03 0,01356894 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 9,664E-03 0,01356115 ! hormone transport GO:0009914 41 23 0,000 9,664E-03 0,01355337 ! cell-cell recognition GO:0009988 28 23 0,000 9,664E-03 0,01354559 ! negative regulation of cytokine production GO:0001818 41 23 0,000 9,664E-03 0,01353782 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 9,664E-03 0,01353006 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 9,664E-03 0,01352232 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,01008254 0,01409939 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,01008254 0,01409132 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,01008254 0,01408327 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,01008254 0,01407522 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,01008254 0,01406718 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,01008254 0,01405915 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,01008254 0,01405113 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,01008254 0,01404312 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,01008254 0,01403512 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,01008254 0,01402713 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 0,000 0,01008254 0,01401914 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,01008254 0,01401117 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,01008254 0,0140032 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,01008254 0,01399525 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,01008254 0,0139873 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,01008254 0,01397936 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,01008254 0,01397143 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,01008254 0,01396351 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,01008254 0,0139556 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,01008254 0,0139477 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,01008254 0,01393981 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,01008254 0,01393192 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,01008254 0,01392405 ! membrane depolarization GO:0051899 45 24 0,000 0,01008254 0,01391618 ! pallium development GO:0021543 56 24 0,000 0,01008254 0,01390832 ! oogenesis GO:0048477 44 24 0,000 0,01008254 0,01390047 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,01008254 0,01389263 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,01008254 0,0138848 ! platelet activation GO:0030168 41 24 0,000 0,01008254 0,01387698 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,01008254 0,01386916 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,01008254 0,01386136 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,01008254 0,01385356 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,01008254 0,01384578 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,01008254 0,013838 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,01008254 0,01383023 ! regulation of amine transport GO:0051952 41 24 0,000 0,01008254 0,01382247 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,01008254 0,01381471 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,01050058 0,01437943 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,01050058 0,01437138 ! leukocyte adhesion GO:0007159 55 25 0,000 0,01050058 0,01436333 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,01050058 0,01435529 ! phototransduction GO:0007602 37 25 0,000 0,01050058 0,01434726 ! keratinization GO:0031424 37 25 0,000 0,01050058 0,01433924 ! vasculogenesis GO:0001570 49 25 0,000 0,01050058 0,01433123 ! vacuole organization GO:0007033 49 25 0,000 0,01050058 0,01432323 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,01050058 0,01431524 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,01050058 0,01430725 ! receptor metabolic process GO:0043112 53 25 0,000 0,01050058 0,01429928 ! chromosome condensation GO:0030261 48 25 0,000 0,01050058 0,01429131 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,01050058 0,01428336 ! regulation of behavior GO:0050795 48 25 0,000 0,01050058 0,01427541 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,01050058 0,01426747 ! interaction with host GO:0051701 66 25 0,000 0,01050058 0,01425954 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,01050058 0,01425161 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,01050058 0,0142437 ! immunoglobulin production GO:0002377 62 25 0,000 0,01050058 0,0142358 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,01050058 0,0142279 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,01050058 0,01422001 ! liver development GO:0001889 55 25 0,000 0,01050058 0,01421214 ! protein tetramerization GO:0051262 57 25 0,000 0,01050058 0,01420427 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,01091845 0,01476136 ! myelination GO:0042552 50 26 0,000 0,01091845 0,01475319 ! initiation of viral infection GO:0019059 60 26 0,000 0,01091845 0,01474504 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,01091845 0,01473689 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,01091845 0,01472875 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,01091845 0,01472063 ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,01091845 0,01471251 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,01091845 0,0147044 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,01091845 0,01469629 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,01091845 0,0146882 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,01091845 0,01468012 ! digestive system process GO:0022600 49 26 0,000 0,01091845 0,01467204 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,01091845 0,01466398 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,01091845 0,01465592 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,01091845 0,01464787 ! osteoblast differentiation GO:0001649 63 26 0,000 0,01091845 0,01463983 ! neural crest cell development GO:0014032 59 26 0,000 0,01091845 0,0146318 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,01091845 0,01462378 ! negative regulation of cell development GO:0010721 83 26 0,000 0,01091845 0,01461577 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,01091845 0,01460776 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,01091845 0,01459977 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,01091845 0,01459178 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,01091845 0,0145838 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,01091845 0,01457583 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,01091845 0,01456787 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,01091845 0,01455992 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,01091845 0,01455198 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,01091845 0,01454404 ! blastocyst development GO:0001824 50 26 0,000 0,01091845 0,01453612 ! telomere organization GO:0032200 46 26 0,000 0,01091845 0,0145282 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,01091845 0,01452029 ! neural tube closure GO:0001843 58 26 0,000 0,01091845 0,01451239 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,01091845 0,0145045 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,01091845 0,01449662 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,01091845 0,01448874 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,01133616 0,01503487 ! embryonic pattern specification GO:0009880 49 27 0,000 0,01133616 0,01502672 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,01133616 0,01501857 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,01133616 0,01501043 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,01133616 0,0150023 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,01133616 0,01499417 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,01133616 0,01498606 ! iron ion transport GO:0006826 65 27 0,000 0,01133616 0,01497796 ! superoxide metabolic process GO:0006801 41 27 0,000 0,01133616 0,01496986 ! tube lumen formation GO:0035148 59 27 0,000 0,01133616 0,01496177 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,01133616 0,01495369 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,01133616 0,01494562 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,01133616 0,01493756 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,01133616 0,01492951 ! response to starvation GO:0042594 47 27 0,000 0,01133616 0,01492147 ! response to toxin GO:0009636 49 27 0,000 0,01133616 0,01491343 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,01133616 0,0149054 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,01133616 0,01489739 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,01133616 0,01488938 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,01133616 0,01488138 ! leukocyte proliferation GO:0070661 59 27 0,000 0,01133616 0,01487338 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,01133616 0,0148654 ! neuron fate commitment GO:0048663 52 28 0,000 0,01175371 0,01540467 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,01175371 0,01539641 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,01175371 0,01538816 ! protein amino acid acylation GO:0043543 59 28 0,000 0,01175371 0,01537992 ! vesicle docking GO:0048278 55 28 0,000 0,01175371 0,01537168 ! circadian rhythm GO:0007623 56 28 0,000 0,01175371 0,01536346 ! dendrite development GO:0016358 67 28 0,000 0,01175371 0,01535524 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,01175371 0,01534704 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,01175371 0,01533884 ! sperm motility GO:0030317 37 28 0,000 0,01175371 0,01533065 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,01175371 0,01532247 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,01175371 0,01531429 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,01175371 0,01530613 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,01175371 0,01529798 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,01175371 0,01528983 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,01175371 0,01528169 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,01175371 0,01527357 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,01175371 0,01526545 ! glutathione metabolic process GO:0006749 42 28 0,000 0,01175371 0,01525733 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,01175371 0,01524923 ! lipid oxidation GO:0034440 48 28 0,000 0,01175371 0,01524114 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,01175371 0,01523305 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,01175371 0,01522498 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,01217109 0,01575727 ! translational initiation GO:0006413 66 29 0,000 0,01217109 0,01574892 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,01217109 0,01574058 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,01217109 0,01573226 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,01217109 0,01572394 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,01217109 0,01571563 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,01217109 0,01570732 ! primary neural tube formation GO:0014020 61 29 0,000 0,01217109 0,01569903 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,01217109 0,01569075 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,01217109 0,01568247 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,01217109 0,0156742 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,01217109 0,01566595 ! somitogenesis GO:0001756 52 29 0,000 0,01217109 0,0156577 ! synaptogenesis GO:0007416 46 29 0,000 0,01217109 0,01564945 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,01217109 0,01564122 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,01217109 0,015633 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,01217109 0,01562478 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,01217109 0,01561658 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,0125883 0,01614342 ! phenol metabolic process GO:0018958 56 30 0,000 0,0125883 0,01613495 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,0125883 0,01612649 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,0125883 0,01611804 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,0125883 0,0161096 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,0125883 0,01610116 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,0125883 0,01609274 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,0125883 0,01608432 ! acute-phase response GO:0006953 50 30 0,000 0,0125883 0,01607591 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,0125883 0,01606751 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,0125883 0,01605912 ! myofibril assembly GO:0030239 50 30 0,000 0,0125883 0,01605074 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,0125883 0,01604237 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,0125883 0,01603401 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,0125883 0,01602565 ! cell fate determination GO:0001709 64 30 0,000 0,0125883 0,0160173 ! phospholipid transport GO:0015914 65 30 0,000 0,0125883 0,01600897 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,0125883 0,01600064 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,0125883 0,01599232 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,0125883 0,015984 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,0125883 0,0159757 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,0125883 0,01596741 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 0,000 0,0125883 0,01595912 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,01300535 0,01647929 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,01300535 0,01647075 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,01300535 0,01646222 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,01300535 0,01645369 ! cell junction assembly GO:0034329 85 31 0,000 0,01300535 0,01644518 ! regulation of innate immune response GO:0045088 57 31 0,000 0,01300535 0,01643667 ! ovulation cycle process GO:0022602 55 31 0,000 0,01300535 0,01642817 ! peptide transport GO:0015833 60 31 0,000 0,01300535 0,01641968 ! male gonad development GO:0008584 56 31 0,000 0,01300535 0,0164112 ! iron ion homeostasis GO:0055072 60 31 0,000 0,01300535 0,01640273 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,01300535 0,01639426 ! detection of light stimulus GO:0009583 44 31 0,000 0,01300535 0,01638581 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,01300535 0,01637736 ! natural killer cell activation GO:0030101 50 31 0,000 0,01300535 0,01636892 ! ensheathment of neurons GO:0007272 64 31 0,000 0,01300535 0,01636049 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,01300535 0,01635207 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,01300535 0,01634366 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,01300535 0,01633526 ! eye morphogenesis GO:0048592 65 31 0,000 0,01300535 0,01632687 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,01300535 0,01631848 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,01342224 0,01683292 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,01342224 0,01682429 ! collagen metabolic process GO:0032963 49 32 0,000 0,01342224 0,01681566 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,01342224 0,01680704 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,01342224 0,01679843 ! metanephros development GO:0001656 81 32 0,000 0,01342224 0,01678983 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,01342224 0,01678124 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,01342224 0,01677265 ! muscle cell development GO:0055001 52 32 0,000 0,01342224 0,01676408 ! mesoderm formation GO:0001707 73 32 0,000 0,01342224 0,01675551 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,01342224 0,01674695 ! ovulation cycle GO:0042698 57 32 0,000 0,01342224 0,01673841 ! peripheral nervous system development GO:0007422 68 32 0,000 0,01342224 0,01672987 ! BMP signaling pathway GO:0030509 71 32 0,000 0,01342224 0,01672133 ! hindbrain development GO:0030902 65 32 0,000 0,01342224 0,01671281 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,01342224 0,0167043 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,01342224 0,01669579 ! gene silencing GO:0016458 71 32 0,000 0,01342224 0,0166873 ! regulation of pH GO:0006885 56 33 0,000 0,01383896 0,01719664 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,01383896 0,0171879 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,01383896 0,01717916 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,01383896 0,01717044 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,01383896 0,01716172 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,01383896 0,01715301 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,01383896 0,01714432 ! response to ionizing radiation GO:0010212 74 33 0,000 0,01383896 0,01713563 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,01383896 0,01712695 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,01383896 0,01711827 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,01383896 0,01710961 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,01383896 0,01710096 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,01383896 0,01709231 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,01383896 0,01708367 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,01383896 0,01707505 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,01425552 0,01758013 ! glial cell differentiation GO:0010001 67 34 0,000 0,01425552 0,01757126 ! post-embryonic development GO:0009791 76 34 0,000 0,01425552 0,0175624 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,01425552 0,01755355 ! cholesterol transport GO:0030301 62 34 0,000 0,01425552 0,01754471 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,01425552 0,01753587 ! spliceosome assembly GO:0000245 75 34 0,000 0,01425552 0,01752705 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,01425552 0,01751823 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,01425552 0,01750942 ! formation of primary germ layer GO:0001704 76 34 0,000 0,01425552 0,01750062 ! cell fate specification GO:0001708 56 34 0,000 0,01425552 0,01749184 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,01425552 0,01748305 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,01425552 0,01747428 ! adult locomotory behavior GO:0008344 62 34 0,000 0,01425552 0,01746552 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,01425552 0,01745676 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,01467192 0,01795766 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,01467192 0,01794867 ! negative regulation of secretion GO:0051048 68 35 0,000 0,01467192 0,01793969 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,01467192 0,01793071 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,01467192 0,01792175 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,01467192 0,01791279 ! membrane docking GO:0022406 69 35 0,000 0,01467192 0,01790384 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,01467192 0,01789491 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,01467192 0,01788598 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,01467192 0,01787705 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,01467192 0,01786814 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,01467192 0,01785924 ! ceramide metabolic process GO:0006672 72 35 0,000 0,01467192 0,01785035 ! telencephalon development GO:0021537 81 35 0,000 0,01467192 0,01784146 ! sterol transport GO:0015918 63 35 0,000 0,01467192 0,01783258 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,01467192 0,01782372 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,01467192 0,01781486 ! vesicle localization GO:0051648 70 35 0,000 0,01467192 0,01780601 ! regulation of muscle development GO:0048634 82 36 0,000 0,01508815 0,01830206 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,01508815 0,01829298 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,01508815 0,0182839 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,01508815 0,01827484 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,01508815 0,01826578 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,01508815 0,01825673 ! positive regulation of cell development GO:0010720 85 36 0,000 0,01508815 0,0182477 ! protein targeting to membrane GO:0006612 75 36 0,000 0,01508815 0,01823867 ! aerobic respiration GO:0009060 56 36 0,000 0,01508815 0,01822965 ! cytokine production GO:0001816 68 36 0,000 0,01508815 0,01822064 ! embryonic organ development GO:0048568 67 36 0,000 0,01508815 0,01821163 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,01508815 0,01820264 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,01508815 0,01819366 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,01550421 0,01868613 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,01550421 0,01867692 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,01550421 0,01866772 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,01550421 0,01865852 ! sister chromatid segregation GO:0000819 65 37 0,000 0,01550421 0,01864933 ! odontogenesis GO:0042476 74 37 0,000 0,01550421 0,01864016 ! actomyosin structure organization GO:0031032 68 37 0,000 0,01550421 0,01863099 ! cell junction organization GO:0034330 96 37 0,000 0,01550421 0,01862183 ! tissue remodeling GO:0048771 78 37 0,000 0,01550421 0,01861268 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,01550421 0,01860353 ! female gonad development GO:0008585 71 37 0,000 0,01550421 0,0185944 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,01550421 0,01858528 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,01550421 0,01857616 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,01550421 0,01856706 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,01550421 0,01855796 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,01592012 0,01904645 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,01592012 0,01903712 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,01592012 0,01902781 ! organic anion transport GO:0015711 82 38 0,000 0,01592012 0,01901851 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,01592012 0,01900921 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,01592012 0,01899992 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,01592012 0,01899065 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,01592012 0,01898138 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,01592012 0,01897212 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,01592012 0,01896287 ! regulation of protein stability GO:0031647 77 38 0,000 0,01592012 0,01895363 ! spermatid development GO:0007286 69 38 0,000 0,01592012 0,0189444 ! pigment metabolic process GO:0042440 87 38 0,000 0,01592012 0,01893517 ! neural tube formation GO:0001841 79 38 0,000 0,01592012 0,01892596 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,01633585 0,01941075 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,01633585 0,01940131 ! negative regulation of binding GO:0051100 71 39 0,000 0,01633585 0,01939188 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,01633585 0,01938246 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,01633585 0,01937305 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,01633585 0,01936365 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,01633585 0,01935426 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,01633585 0,01934488 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,01633585 0,01933551 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,01633585 0,01932615 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,01675143 0,0198082 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,01675143 0,01979862 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,01675143 0,01978904 ! learning GO:0007612 82 40 0,000 0,01675143 0,01977948 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,01675143 0,01976992 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,01675143 0,01976038 ! lipid homeostasis GO:0055088 75 40 0,000 0,01675143 0,01975084 ! mismatch repair GO:0006298 58 40 0,000 0,01675143 0,01974131 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,01675143 0,01973179 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,01675143 0,01972228 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,01675143 0,01971278 ! RNA export from nucleus GO:0006405 61 41 0,000 0,01716684 0,02019191 ! mRNA catabolic process GO:0006402 79 41 0,000 0,01716684 0,02018219 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,01716684 0,02017248 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,01716684 0,02016278 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,01716684 0,02015309 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,01716684 0,02014341 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,01716684 0,02013374 ! gliogenesis GO:0042063 91 41 0,000 0,01716684 0,02012408 ! feeding behavior GO:0007631 69 41 0,000 0,01716684 0,02011443 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,01716684 0,02010479 ! mesenchymal cell development GO:0014031 94 41 0,000 0,01716684 0,02009515 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,01716684 0,02008553 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,01716684 0,02007592 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,01716684 0,02006631 ! spermatid differentiation GO:0048515 73 41 0,000 0,01716684 0,02005671 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,01716684 0,02004713 ! RNA modification GO:0009451 64 41 0,000 0,01716684 0,02003755 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,01758209 0,02051243 ! ear morphogenesis GO:0042471 64 42 0,000 0,01758209 0,02050264 ! organic ether metabolic process GO:0018904 59 42 0,000 0,01758209 0,02049286 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,01758209 0,02048309 ! regulation of intracellular protein transport GO:0033157 86 42 0,000 0,01758209 0,02047332 ! T cell differentiation GO:0030217 93 42 0,000 0,01758209 0,02046357 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,01758209 0,02045383 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,01758209 0,02044409 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,01758209 0,02043436 ! regulation of protein secretion GO:0050708 77 42 0,000 0,01758209 0,02042465 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,01758209 0,02041494 ! cytokinesis GO:0000910 84 42 0,000 0,01758209 0,02040524 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,01758209 0,02039555 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,01799717 0,02086715 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 0,000 0,01799717 0,02085725 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,01799717 0,02084736 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,01799717 0,02083748 ! regulation of tube size GO:0035150 76 43 0,000 0,01799717 0,02082761 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,01799717 0,02081775 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,01799717 0,0208079 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,01799717 0,02079805 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,01799717 0,02078822 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,01799717 0,02077839 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,01799717 0,02076858 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,01799717 0,02075877 ! segmentation GO:0035282 78 43 0,000 0,01799717 0,02074898 ! ion transmembrane transport GO:0034220 79 43 0,000 0,01799717 0,02073919 ! neuron migration GO:0001764 85 43 0,000 0,01799717 0,02072941 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,01799717 0,02071964 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,01841209 0,02118734 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,01841209 0,02117737 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,01841209 0,0211674 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,01841209 0,02115745 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,01841209 0,0211475 ! striated muscle contraction GO:0006941 85 44 0,000 0,01841209 0,02113756 ! phagocytosis GO:0006909 105 44 0,000 0,01841209 0,02112763 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,01841209 0,02111771 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,01882684 0,02158328 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,01882684 0,02157316 ! regulation of epithelial cell proliferation GO:0050678 122 45 0,000 0,01882684 0,02156305 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,01882684 0,02155294 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! B cell differentiation GO:0030183 124 45 0,000 0,01882684 0,02154285 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,01882684 0,02153276 ! female gamete generation GO:0007292 71 45 0,000 0,01882684 0,02152268 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,01882684 0,02151262 ! polyol metabolic process GO:0019751 77 45 0,000 0,01882684 0,02150256 ! maintenance of location in cell GO:0051651 101 45 0,000 0,01882684 0,02149251 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,01924143 0,02195555 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,01924143 0,0219453 ! glycolysis GO:0006096 71 46 0,000 0,01924143 0,02193506 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 0,000 0,01924143 0,02192483 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,01924143 0,0219146 ! leukocyte migration GO:0050900 75 46 0,000 0,01924143 0,02190439 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,01924143 0,02189419 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,01924143 0,021884 ! pigmentation GO:0043473 103 46 0,000 0,01924143 0,02187381 ! cell growth GO:0016049 90 46 0,000 0,01924143 0,02186364 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,01924143 0,02185348 ! neural tube development GO:0021915 91 47 0,000 0,01965586 0,02231379 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,01965586 0,02230342 ! positive regulation of defense response GO:0031349 88 48 0,000 0,02007013 0,02276292 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,02007013 0,02275235 ! mitochondrial transport GO:0006839 94 48 0,000 0,02007013 0,0227418 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,02007013 0,02273126 ! cellular component disassembly GO:0022411 89 48 0,000 0,02007013 0,02272072 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,02007013 0,0227102 ! endosome transport GO:0016197 127 48 0,000 0,02007013 0,02269969 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,02007013 0,02268918 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,02007013 0,02267869 ! male sex differentiation GO:0046661 93 48 0,000 0,02007013 0,0226682 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,02007013 0,02265773 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,02007013 0,02264726 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,02007013 0,02263681 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,02007013 0,02262636 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,02048423 0,02308255 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,02048423 0,02307191 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,02048423 0,02306128 ! JNK cascade GO:0007254 106 49 0,000 0,02048423 0,02305066 ! protein homooligomerization GO:0051260 84 49 0,000 0,02048423 0,02304004 ! regulation of action potential GO:0001508 102 50 0,000 0,02089817 0,02349481 ! regulation of ion transport GO:0043269 86 50 0,000 0,02089817 0,023484 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,02089817 0,02347321 ! endocrine system development GO:0035270 109 50 0,000 0,02089817 0,02346242 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,02089817 0,02345164 ! activation of caspase activity GO:0006919 95 50 0,000 0,02089817 0,02344087 ! regulation of ossification GO:0030278 123 50 0,000 0,02089817 0,02343012 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,02089817 0,02341937 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,02089817 0,02340863 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,02089817 0,0233979 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,02089817 0,02338718 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,02131194 0,02383932 ! viral infectious cycle GO:0019058 104 51 0,000 0,02131194 0,02382841 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,02131194 0,02381751 ! peptide metabolic process GO:0006518 80 51 0,000 0,02131194 0,02380662 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,02131194 0,02379574 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,02131194 0,02378487 ! positive regulation of binding GO:0051099 88 52 0,000 0,02172555 0,0242354 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,02172555 0,02422434 ! Notch signaling pathway GO:0007219 111 52 0,000 0,02172555 0,02421329 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,02172555 0,02420225 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,02172555 0,02419122 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,02172555 0,0241802 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,02172555 0,02416918 ! excretion GO:0007588 87 52 0,000 0,02172555 0,02415818 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,02172555 0,02414719 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,02172555 0,02413621 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,02172555 0,02412524 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,02172555 0,02411428 ! amino acid activation GO:0043038 98 52 0,000 0,02172555 0,02410333 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,022139 0,02455088 ! inner ear development GO:0048839 89 53 0,000 0,022139 0,02453974 ! chromatin remodeling GO:0006338 122 53 0,000 0,022139 0,02452861 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,022139 0,02451749 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,022139 0,02450638 ! vesicle organization GO:0016050 127 53 0,000 0,022139 0,02449528 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,022139 0,02448419 ! cartilage development GO:0051216 99 53 0,000 0,022139 0,02447312 ! synapse organization GO:0050808 102 53 0,000 0,022139 0,02446205 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,02255229 0,02490743 ! regulation of translational initiation GO:0006446 87 54 0,000 0,02255229 0,02489618 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,02255229 0,02488493 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,02255229 0,0248737 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,02255229 0,02486247 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,02255229 0,02485126 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,02255229 0,02484005 ! membrane fusion GO:0006944 122 54 0,000 0,02255229 0,02482886 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,02255229 0,02481768 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,02255229 0,0248065 ! regulation of cell shape GO:0008360 142 54 0,000 0,02255229 0,02479534 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,02255229 0,02478418 ! RNA catabolic process GO:0006401 103 55 0,000 0,02296541 0,02522684 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,02296541 0,02521551 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,02296541 0,02520418 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,02296541 0,02519286 ! cell recognition GO:0008037 98 55 0,000 0,02296541 0,02518155 ! cell maturation GO:0048469 107 55 0,000 0,02296541 0,02517026 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,02296541 0,02515897 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,02296541 0,02514769 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,02337837 0,02558842 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,02337837 0,02557696 ! glucose catabolic process GO:0006007 88 56 0,000 0,02337837 0,02556551 ! RNA elongation GO:0006354 90 56 0,000 0,02337837 0,02555408 ! chloride transport GO:0006821 102 57 0,000 0,02379117 0,02599366 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,02379117 0,02598204 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,02379117 0,02597043 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 0,000 0,02379117 0,02595883 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,02379117 0,02594724 ! heart morphogenesis GO:0003007 105 57 0,000 0,02379117 0,02593566 ! regulation of intracellular transport GO:0032386 108 57 0,000 0,02379117 0,0259241 ! regulation of actin filament length GO:0030832 118 58 0,000 0,0242038 0,02636196 ! positive regulation of cell migration GO:0030335 137 58 0,000 0,0242038 0,02635022 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,0242038 0,02633848 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,0242038 0,02632675 ! aging GO:0007568 112 58 0,000 0,0242038 0,02631504 ! gastrulation GO:0007369 122 58 0,000 0,0242038 0,02630333 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,0242038 0,02629163 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,0242038 0,02627995 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,0242038 0,02626827 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,0242038 0,02625661 ! maintenance of location GO:0051235 124 58 0,000 0,0242038 0,02624496 ! nuclear export GO:0051168 110 59 0,000 0,02461627 0,02668037 ! establishment of organelle localization GO:0051656 122 59 0,000 0,02461627 0,02666854 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,02502858 0,0271032 ! lipid modification GO:0030258 112 60 0,000 0,02502858 0,02709119 ! DNA catabolic process GO:0006308 94 60 0,000 0,02502858 0,02707919 ! regulation of endocytosis GO:0030100 104 60 0,000 0,02502858 0,02706721 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,02502858 0,02705523 ! adult behavior GO:0030534 104 60 0,000 0,02502858 0,02704326 ! kidney development GO:0001822 133 60 0,000 0,02502858 0,02703131 ! positive regulation of secretion GO:0051047 110 61 0,000 0,02544073 0,02746429 ! regulation of cellular component size GO:0032535 125 61 0,000 0,02544073 0,02745216 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,02544073 0,02744004 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,02544073 0,02742793 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,02544073 0,02741583 ! regulation of heart contraction GO:0008016 123 61 0,000 0,02544073 0,02740374 ! camera-type eye development GO:0043010 126 61 0,000 0,02544073 0,02739167 ! proton transport GO:0015992 117 61 0,000 0,02544073 0,0273796 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,02544073 0,02736754 ! viral reproductive process GO:0022415 132 62 0,000 0,02585271 0,02779849 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,02585271 0,02778626 ! tRNA processing GO:0008033 102 62 0,000 0,02585271 0,02777404 ! regulation of homeostatic process GO:0032844 148 62 0,000 0,02585271 0,02776183 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,02626453 0,02819167 ! regulation of mitosis GO:0007088 112 63 0,000 0,02626453 0,02817929 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,02626453 0,02816692 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,02626453 0,02815456 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,02626453 0,02814221 ! hydrogen transport GO:0006818 121 64 0,000 0,02667619 0,02857077 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,02667619 0,02855825 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,02667619 0,02854574 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,02708768 0,02897338 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,02708768 0,0289607 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,02708768 0,02894803 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,02708768 0,02893538 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,02708768 0,02892273 ! positive regulation of cell motion GO:0051272 157 65 0,000 0,02708768 0,02891009 ! ear development GO:0043583 114 66 0,000 0,02749901 0,02933629 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,02749901 0,02932348 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,02749901 0,02931069 ! gonad development GO:0008406 115 66 0,000 0,02749901 0,0292979 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,02749901 0,02928513 ! activation of MAPK activity GO:0000187 124 67 0,000 0,02791019 0,02971006 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,02791019 0,02969712 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,02791019 0,02968419 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,02791019 0,02967127 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,02791019 0,02965837 ! secondary metabolic process GO:0019748 125 67 0,000 0,02791019 0,02964547 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,02791019 0,02963259 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,02832119 0,0300559 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,02832119 0,03004285 ! hexose catabolic process GO:0019320 113 68 0,000 0,02832119 0,03002981 ! extracellular matrix organization GO:0030198 146 68 0,000 0,02832119 0,03001678 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,02832119 0,03000376 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,02832119 0,02999076 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,02832119 0,02997776 ! viral reproduction GO:0016032 142 68 0,000 0,02832119 0,02996478 ! regulation of lipase activity GO:0060191 137 68 0,000 0,02832119 0,02995181 ! adaptive immune response GO:0002250 126 68 0,000 0,02832119 0,02993885 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 0,000 0,02832119 0,0299259 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,02873204 0,0303469 ! lung development GO:0030324 165 69 0,000 0,02873204 0,03033378 ! urogenital system development GO:0001655 149 69 0,000 0,02873204 0,03032068 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 0,000 0,02873204 0,03030759 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,02873204 0,03029451 ! single fertilization GO:0007338 83 69 0,000 0,02873204 0,03028144 ! cell redox homeostasis GO:0045454 114 70 0,000 0,02914272 0,03070102 ! activation of immune response GO:0002253 120 70 0,000 0,02914272 0,03068779 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,02914272 0,03067457 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,02955325 0,03109327 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,02955325 0,03107989 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,02955325 0,03106652 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,02955325 0,03105315 ! appendage morphogenesis GO:0035107 150 72 0,000 0,02996361 0,0314708 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 171 72 0,000 0,02996361 0,03145728 ! actin filament organization GO:0007015 167 72 0,000 0,02996361 0,03144377 ! B cell activation GO:0042113 179 72 0,000 0,02996361 0,03143027 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,02996361 0,03141678 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,02996361 0,0314033 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,02996361 0,03138983 ! appendage development GO:0048736 151 73 0,000 0,0303738 0,03180592 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,0303738 0,03179229 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,0303738 0,03177867 ! regulation of immune effector process GO:0002697 156 73 0,000 0,0303738 0,03176507 ! acute inflammatory response GO:0002526 118 74 0,000 0,03078384 0,03218011 ! amino acid transport GO:0006865 148 74 0,000 0,03078384 0,03216635 ! respiratory system development GO:0060541 175 74 0,000 0,03078384 0,0321526 ! organelle localization GO:0051640 155 74 0,000 0,03078384 0,03213886 ! regulation of transcription factor activity GO:0051090 137 75 0,000 0,03119372 0,03255286 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 143 75 0,000 0,03119372 0,03253896 ! reproductive structure development GO:0048608 131 75 0,000 0,03119372 0,03252507 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,03119372 0,0325112 ! eye development GO:0001654 155 75 0,000 0,03119372 0,03249733 ! axon guidance GO:0007411 162 75 0,000 0,03119372 0,03248348 ! rhythmic process GO:0048511 142 75 0,000 0,03119372 0,03246964 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,03160343 0,0328821 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,03160343 0,0328681 ! learning or memory GO:0007611 161 76 0,000 0,03160343 0,03285412 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,03160343 0,03284014 ! regulation of blood pressure GO:0008217 134 76 0,000 0,03160343 0,03282618 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,03160343 0,03281223 ! amine catabolic process GO:0009310 136 77 0,000 0,03201298 0,03322332 ! neurotransmitter transport GO:0006836 142 77 0,000 0,03201298 0,03320922 ! phosphoinositide metabolic process GO:0030384 146 77 0,000 0,03201298 0,03319512 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,03201298 0,03318104 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,03201298 0,03316697 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,03201298 0,03315291 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,03242237 0,03356265 ! antigen processing and presentation GO:0019882 117 78 0,000 0,03242237 0,03354843 ! fertilization GO:0009566 99 78 0,000 0,03242237 0,03353423 ! blood coagulation GO:0007596 151 79 0,000 0,0328316 0,03394312 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,0328316 0,03392876 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,0328316 0,03391441 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,0328316 0,03390008 ! protein oligomerization GO:0051259 149 79 0,000 0,0328316 0,03388576 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,0328316 0,03387145 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,03324066 0,03427899 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,03324066 0,03426453 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,03324066 0,03425008 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,03324066 0,03423564 ! muscle cell differentiation GO:0042692 178 81 0,000 0,03364957 0,03464218 ! response to hypoxia GO:0001666 178 81 0,000 0,03364957 0,03462759 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,03364957 0,03461301 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,03405831 0,03501871 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,03446689 0,0354239 ! exocytosis GO:0006887 153 83 0,000 0,03446689 0,035409 ! response to drug GO:0042493 149 83 0,000 0,03446689 0,03539412 ! response to oxygen levels GO:0070482 183 83 0,000 0,03446689 0,03537925 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,03446689 0,03536439 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,03446689 0,03534954 ! inorganic anion transport GO:0015698 156 83 0,000 0,03446689 0,03533471 ! T cell activation GO:0042110 189 84 0,000 0,03487531 0,03573842 ! response to nutrient GO:0007584 135 84 0,000 0,03487531 0,03572343 ! digestion GO:0007586 130 84 0,000 0,03487531 0,03570846 ! hemostasis GO:0007599 165 85 0,000 0,03528357 0,03611134 ! negative regulation of transport GO:0051051 164 85 0,000 0,03528357 0,03609622 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,03528357 0,03608111 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,03528357 0,03606601 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,03528357 0,03605093 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,03528357 0,03603585 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,03569167 0,03643742 ! regulation of lyase activity GO:0051339 169 86 0,000 0,03569167 0,0364222 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,0360996 0,0368231 ! alcohol catabolic process GO:0046164 142 87 0,000 0,0360996 0,03680774 ! nucleosome assembly GO:0006334 126 87 0,000 0,0360996 0,03679238 ! regulation of protein transport GO:0051223 165 87 0,000 0,0360996 0,03677704 GO:0070201|regulation of establishment of protein localization, ! cellular respiration GO:0045333 143 88 0,000 0,03650738 0,03717696 ! amine biosynthetic process GO:0009309 146 88 0,000 0,03650738 0,03716147 ! sensory perception of smell GO:0007608 117 88 0,000 0,03650738 0,03714599 ! chromatin assembly GO:0031497 128 88 0,000 0,03650738 0,03713053 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,036915 0,03752948 ! regulation of DNA binding GO:0051101 167 89 0,000 0,036915 0,03751387 ! tube morphogenesis GO:0035239 194 89 0,000 0,036915 0,03749827 ! cellular defense response GO:0006968 123 89 0,000 0,036915 0,03748268 ! regulation of neurological system process GO:0031644 175 89 0,000 0,036915 0,03746711 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,03732245 0,03786493 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,03732245 0,03784921 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,03772974 0,03824637 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,03772974 0,03823051 ! gland development GO:0048732 220 91 0,000 0,03772974 0,03821466 ! defense response to bacterium GO:0042742 112 91 0,000 0,03772974 0,03819882 ! bone development GO:0060348 206 92 0,000 0,03813687 0,03859502 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,03813687 0,03857904 ! regulation of cell adhesion GO:0030155 241 92 0,000 0,03813687 0,03856307 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,03854385 0,03895847 ! amine transport GO:0015837 181 93 0,000 0,03854385 0,03894236 ! positive regulation of MAP kinase activity GO:0043406 174 93 0,000 0,03854385 0,03892626 ! vitamin metabolic process GO:0006766 153 93 0,000 0,03854385 0,03891017 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,03895066 0,03930461 ! female pregnancy GO:0007565 166 94 0,000 0,03895066 0,03928838 ! sterol metabolic process GO:0016125 166 94 0,000 0,03895066 0,03927216 ! regulation of membrane potential GO:0042391 179 94 0,000 0,03895066 0,03925596 ! regulation of defense response GO:0031347 171 95 0,000 0,03935731 0,03964944 ! nucleosome organization GO:0034728 143 95 0,000 0,03935731 0,0396331 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,03935731 0,03961677 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,03935731 0,03960045 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,03935731 0,03958415 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,03935731 0,03956786 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,03935731 0,03955158 ! sex differentiation GO:0007548 171 96 0,000 0,0397638 0,03994365 ! regulation of T cell activation GO:0050863 175 96 0,000 0,0397638 0,03992723 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,04017012 0,04031866 ! transcription initiation GO:0006352 171 97 0,000 0,04017012 0,0403021 ! regulation of protein localization GO:0032880 188 97 0,000 0,04017012 0,04028556 ! leukocyte differentiation GO:0002521 232 98 0,000 0,04057629 0,04067619 ! forebrain development GO:0030900 210 98 0,000 0,04057629 0,04065951 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,04057629 0,04064284 ! skeletal muscle tissue development GO:0007519 223 100 0,000 0,04138815 0,04143904 GO:0060538|skeletal muscle organ development, ! mRNA transport GO:0051028 185 100 0,000 0,04138815 0,04142206 ! positive regulation of immune response GO:0050778 175 100 0,000 0,04138815 0,0414051 ! hormone metabolic process GO:0042445 171 100 0,000 0,04138815 0,04138815