pValThreshold = 0.5 scoreFile = /home/data/iti/output/run-a1/out-0.05-06-0.01-300-run-a1//th1-pval-1e-02-02-th2-pval-1e-01-11-th3-pval-1e-01-01-run-a1/go_data/2068-2-real-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 8,783E-09 2,02E-05 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 2,000 5,152E-08 5,925E-05 ! nucleoside diphosphate metabolic process GO:0009132 8 7 2,000 9,008E-08 6,906E-05 ! response to UV GO:0009411 75 46 3,000 5,096E-07 2,93E-04 ! deoxyribonucleotide metabolic process GO:0009262 27 21 2,000 3,378E-06 1,554E-03 ! response to light stimulus GO:0009416 153 96 3,000 9,887E-06 3,79E-03 ! negative regulation of protein ubiquitination GO:0031397 7 5 1,000 1,958E-05 6,434E-03 ! positive regulation of Rho GTPase activity GO:0032321 9 5 1,000 1,958E-05 5,63E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 2,465E-05 6,299E-03 ! epidermal cell differentiation GO:0009913 53 40 2,000 2,465E-05 5,669E-03 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 1,000 2,935E-05 6,136E-03 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 1,000 2,935E-05 5,625E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 3,07E-05 5,431E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 4,105E-05 6,744E-03 ! regulation of focal adhesion formation GO:0051893 17 7 1,000 4,105E-05 6,294E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 5,468E-05 7,861E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 5,468E-05 7,399E-03 ! keratinocyte proliferation GO:0043616 12 8 1,000 5,468E-05 6,987E-03 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 5,468E-05 6,62E-03 ! positive regulation of GTPase activity GO:0043547 21 9 1,000 7,025E-05 8,078E-03 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 1,000 7,025E-05 7,694E-03 ! regulation of stress fiber formation GO:0051492 20 9 1,000 7,025E-05 7,344E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 7,183E-05 7,183E-03 ! negative regulation of kinase activity GO:0033673 100 58 2,000 7,568E-05 7,253E-03 ! regulation of B cell proliferation GO:0030888 15 10 1,000 8,773E-05 8,071E-03 ! regulation of phosphatase activity GO:0010921 21 10 1,000 8,773E-05 7,761E-03 ! UV protection GO:0009650 14 10 1,000 8,773E-05 7,473E-03 ! regulation of actin filament bundle formation GO:0032231 21 10 1,000 8,773E-05 7,207E-03 ! negative regulation of transferase activity GO:0051348 105 61 2,000 8,802E-05 6,981E-03 ! protein oligomerization GO:0051259 100 65 2,000 1,064E-04 8,159E-03 ! regulation of Rho GTPase activity GO:0032319 18 11 1,000 1,071E-04 7,949E-03 ! positive regulation of cell growth GO:0030307 16 12 1,000 1,284E-04 9,232E-03 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 1,768E-04 0,01232189 GO:0031114|regulation of microtubule depolymerization, ! negative regulation of caspase activity GO:0043154 20 14 1,000 1,768E-04 0,01195948 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,768E-04 0,01161778 ! regulation of protein ubiquitination GO:0031396 19 15 1,000 2,038E-04 0,01302134 ! positive regulation of cell size GO:0045793 20 15 1,000 2,038E-04 0,01266942 ! skin development GO:0043588 25 15 1,000 2,038E-04 0,01233601 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 2,038E-04 0,0120197 ! cellular response to unfolded protein GO:0034620 19 16 1,000 2,327E-04 0,01338164 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of dephosphorylation GO:0035303 33 16 1,000 2,327E-04 0,01305526 ! negative regulation of translation GO:0017148 22 16 1,000 2,327E-04 0,01274442 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 2,445E-04 0,01307575 ! interphase GO:0051325 159 88 2,000 2,616E-04 0,01367625 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 2,635E-04 0,01346895 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 2,962E-04 0,01481018 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 3,079E-04 0,01506905 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 3,308E-04 0,01584896 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 3,308E-04 0,01552552 ! positive regulation of B cell activation GO:0050871 31 20 1,000 3,672E-04 0,01689075 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 3,701E-04 0,01669082 ! regulation of translation GO:0006417 151 100 2,000 3,812E-04 0,01686022 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 4,055E-04 0,01759657 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 4,055E-04 0,01727071 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 4,055E-04 0,0169567 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 4,055E-04 0,0166539 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 4,055E-04 0,01636173 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 4,456E-04 0,01767209 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 4,456E-04 0,01737257 GO:0010810|regulation of cell-substrate adhesion, ! positive regulation of cell adhesion GO:0045785 37 23 1,000 4,877E-04 0,01869359 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 4,877E-04 0,01838714 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 4,877E-04 0,01809057 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 4,877E-04 0,01780342 ! fat cell differentiation GO:0045444 37 24 1,000 5,315E-04 0,0191017 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 5,772E-04 0,02042538 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of protein modification process GO:0031400 50 26 1,000 6,248E-04 0,02177314 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 6,248E-04 0,02144817 ! regulation of B cell activation GO:0050864 42 28 1,000 7,254E-04 0,02453599 ! spindle organization GO:0007051 37 30 1,000 8,333E-04 0,02777794 ! regulation of microtubule-based process GO:0032886 58 30 1,000 8,333E-04 0,02738111 ! meiosis I GO:0007127 52 32 1,000 9,485E-04 0,03072716 ! RNA export from nucleus GO:0006405 44 33 1,000 1,009E-03 0,03222702 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 1,009E-03 0,03178555 ! keratinocyte differentiation GO:0030216 47 35 1,000 1,135E-03 0,03527307 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 1,135E-03 0,03480276 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 1,408E-03 0,04262277 ! response to calcium ion GO:0051592 58 40 1,000 1,481E-03 0,04424465 ! response to insulin stimulus GO:0032868 63 43 1,000 1,71E-03 0,05043241 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 1,79E-03 0,05211953 ! positive regulation of cell cycle GO:0045787 77 45 1,000 1,872E-03 0,05381479 ! regulation of translational initiation GO:0006446 64 45 1,000 1,872E-03 0,05315041 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 1,955E-03 0,05484069 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 2,04E-03 0,05653847 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 2,04E-03 0,05586539 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! nuclear export GO:0051168 69 48 1,000 2,127E-03 0,05755812 ! RNA elongation GO:0006354 62 49 1,000 2,216E-03 0,05925778 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 2,306E-03 0,060964 ! positive regulation of growth GO:0045927 67 50 1,000 2,306E-03 0,06027122 ! nucleotide-excision repair GO:0006289 64 52 1,000 2,492E-03 0,06439474 ! DNA catabolic process GO:0006308 67 54 1,000 2,684E-03 0,06860161 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 2,884E-03 0,07288816 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 2,986E-03 0,07465227 ! meiosis GO:0007126 96 61 1,000 3,412E-03 0,08438153 GO:0051327|M phase of meiotic cell cycle, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 3,412E-03 0,08348386 ! negative regulation of cell growth GO:0030308 106 62 1,000 3,523E-03 0,08528401 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 3,523E-03 0,08439563 ! meiotic cell cycle GO:0051321 97 62 1,000 3,523E-03 0,08352557 ! cell cycle checkpoint GO:0000075 108 64 1,000 3,749E-03 0,08798427 ! negative regulation of cell size GO:0045792 108 64 1,000 3,749E-03 0,08709554 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 3,749E-03 0,08622458 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 3,749E-03 0,08537087 ! regulation of caspase activity GO:0043281 97 65 1,000 3,865E-03 0,08714133 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 3,865E-03 0,0862953 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 3,865E-03 0,08546554 ! regulation of actin filament-based process GO:0032970 99 66 1,000 3,982E-03 0,0872207 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 3,982E-03 0,08639786 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 4,101E-03 0,0881469 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 4,221E-03 0,08989853 ! positive regulation of ligase activity GO:0051351 99 69 1,000 4,344E-03 0,09165259 ! response to metal ion GO:0010038 103 70 1,000 4,467E-03 0,09340891 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 4,467E-03 0,09256739 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 4,467E-03 0,09174089 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 4,593E-03 0,09348295 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 4,593E-03 0,09266293 ! regulation of peptidase activity GO:0052547 106 72 1,000 4,72E-03 0,09439917 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 4,72E-03 0,09358538 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 4,72E-03 0,0927855 ! mitochondrion organization GO:0007005 104 73 1,000 4,849E-03 0,09450813 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 4,979E-03 0,09623303 ! response to inorganic substance GO:0010035 115 75 1,000 5,111E-03 0,09796006 ! negative regulation of growth GO:0045926 123 75 1,000 5,111E-03 0,09715047 ! regulation of ligase activity GO:0051340 114 75 1,000 5,111E-03 0,09635416 ! response to unfolded protein GO:0006986 99 76 1,000 5,245E-03 0,09806811 ! positive regulation of protein modification process GO:0031401 107 78 1,000 5,516E-03 0,10232066 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 5,795E-03 0,10662241 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 1,000 5,795E-03 0,1057762 ! response to protein stimulus GO:0051789 111 81 1,000 5,936E-03 0,10750623 ! positive regulation of cell activation GO:0050867 120 81 1,000 5,936E-03 0,10666633 GO:0002696|positive regulation of leukocyte activation, ! regulation of cell adhesion GO:0030155 159 83 1,000 6,224E-03 0,11097022 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 6,37E-03 0,11270398 ! transcription initiation GO:0006352 118 85 1,000 6,518E-03 0,11443876 ! cell cycle arrest GO:0007050 150 86 1,000 6,667E-03 0,11617447 ! establishment of RNA localization GO:0051236 128 88 1,000 6,971E-03 0,12054791 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 7,131E-03 0,12239097 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 7,131E-03 0,12148437 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 7,131E-03 0,1205911 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 7,131E-03 0,11971087 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 7,131E-03 0,1188434 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 7,131E-03 0,11798841 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 7,131E-03 0,11714564 ! sleep GO:0030431 11 5 0,000 7,131E-03 0,11631482 ! negative regulation of bone resorption GO:0045779 10 5 0,000 7,131E-03 0,1154957 ! nucleotide-sugar transport GO:0015780 8 5 0,000 7,131E-03 0,11468804 ! regulation of interferon-beta production GO:0032648 5 5 0,000 7,131E-03 0,11389159 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 7,131E-03 0,11310613 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 7,131E-03 0,11233144 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 7,131E-03 0,11156728 ! tongue development GO:0043586 6 5 0,000 7,131E-03 0,11081344 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 7,131E-03 0,11006973 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 7,131E-03 0,10933593 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 7,131E-03 0,10861185 ! cobalt ion transport GO:0006824 9 5 0,000 7,131E-03 0,1078973 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 7,131E-03 0,10719209 ! SMAD protein complex assembly GO:0007183 9 5 0,000 7,131E-03 0,10649604 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 7,131E-03 0,10580896 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 7,131E-03 0,1051307 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 7,131E-03 0,10446108 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 7,131E-03 0,10379993 ! embryonic camera-type eye development GO:0031076 8 5 0,000 7,131E-03 0,1031471 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 7,131E-03 0,10250243 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 7,131E-03 0,10186577 ! adaptation of signaling pathway GO:0022401 7 5 0,000 7,131E-03 0,10123697 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 7,131E-03 0,10061589 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 7,131E-03 0,10000238 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 7,131E-03 0,0993963 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 7,131E-03 0,09879753 ! positive regulation of histone modification GO:0031058 5 5 0,000 7,131E-03 0,09820593 ! malate metabolic process GO:0006108 7 5 0,000 7,131E-03 0,09762137 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 7,131E-03 0,09704372 ! behavioral response to pain GO:0048266 7 5 0,000 7,131E-03 0,09647288 ! clathrin coat assembly GO:0048268 11 5 0,000 7,131E-03 0,09590871 ! phototransduction, visible light GO:0007603 6 5 0,000 7,131E-03 0,0953511 ! regulation of dopamine uptake GO:0051584 9 5 0,000 7,131E-03 0,09479994 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 7,131E-03 0,09425511 ! mating behavior GO:0007617 6 5 0,000 7,131E-03 0,09371651 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 7,131E-03 0,09318403 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 7,131E-03 0,09265757 ! rhythmic behavior GO:0007622 12 5 0,000 7,131E-03 0,09213702 ! copulation GO:0007620 7 5 0,000 7,131E-03 0,09162229 ! glial cell fate commitment GO:0021781 12 5 0,000 7,131E-03 0,09111328 ! protein maturation by protein folding GO:0022417 12 5 0,000 7,131E-03 0,09060989 ! embryonic hemopoiesis GO:0035162 10 5 0,000 7,131E-03 0,09011203 ! regulation of potassium ion transport GO:0043266 9 5 0,000 7,131E-03 0,08961961 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 7,131E-03 0,08913255 ! apoptotic cell clearance GO:0043277 13 5 0,000 7,131E-03 0,08865075 ! lipoprotein particle clearance GO:0034381 9 5 0,000 7,131E-03 0,08817414 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 7,131E-03 0,08770262 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 7,131E-03 0,08723611 ! response to protozoan GO:0001562 9 5 0,000 7,131E-03 0,08677455 ! positive regulation of glycolysis GO:0045821 11 5 0,000 7,131E-03 0,08631784 ! lymph vessel development GO:0001945 7 5 0,000 7,131E-03 0,08586591 ! endochondral ossification GO:0001958 12 5 0,000 7,131E-03 0,0854187 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 7,131E-03 0,08497611 ! parathyroid gland development GO:0060017 8 5 0,000 7,131E-03 0,08453809 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 7,131E-03 0,08410456 ! anagen GO:0042640 6 5 0,000 7,131E-03 0,08367546 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 7,131E-03 0,08325071 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 7,131E-03 0,08283025 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 7,131E-03 0,08241402 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 7,131E-03 0,08200195 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 7,131E-03 0,08159398 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 7,131E-03 0,08119005 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 7,131E-03 0,0807901 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 7,131E-03 0,08039407 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 7,131E-03 0,0800019 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 7,131E-03 0,07961354 ! cardiac muscle fiber development GO:0048739 7 5 0,000 7,131E-03 0,07922893 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 7,131E-03 0,07884803 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 7,131E-03 0,07847076 ! neutrophil mediated immunity GO:0002446 6 5 0,000 7,131E-03 0,07809709 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 7,131E-03 0,07772696 ! ovulation GO:0030728 6 5 0,000 7,131E-03 0,07736033 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 7,131E-03 0,07699713 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 7,131E-03 0,07663733 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 7,131E-03 0,07628088 ! response to pH GO:0009268 9 5 0,000 7,131E-03 0,07592773 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 7,131E-03 0,07557783 ! proline biosynthetic process GO:0006561 6 5 0,000 7,131E-03 0,07523114 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 7,131E-03 0,07488762 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 7,131E-03 0,07454723 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 7,131E-03 0,07420991 ! polyol catabolic process GO:0046174 7 5 0,000 7,131E-03 0,07387563 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 7,131E-03 0,07354435 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 7,131E-03 0,07321602 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 7,131E-03 0,07289062 ! sister chromatid cohesion GO:0007062 9 5 0,000 7,131E-03 0,0725681 ! nerve growth factor processing GO:0032455 7 5 0,000 7,131E-03 0,07224841 ! urea metabolic process GO:0019627 6 5 0,000 7,131E-03 0,07193153 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 7,131E-03 0,07161742 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 7,131E-03 0,07130604 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 7,131E-03 0,07099736 ! neutrophil activation GO:0042119 5 5 0,000 7,131E-03 0,07069133 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 7,131E-03 0,07038794 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 7,131E-03 0,07008713 ! response to food GO:0032094 5 5 0,000 7,131E-03 0,06978889 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 7,131E-03 0,06949318 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 7,131E-03 0,06919996 ! paraxial mesoderm development GO:0048339 9 5 0,000 7,131E-03 0,0689092 ! forebrain neuron development GO:0021884 7 5 0,000 7,131E-03 0,06862088 ! melanosome organization GO:0032438 7 5 0,000 7,131E-03 0,06833496 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 7,131E-03 0,06805141 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 7,131E-03 0,0677702 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 7,131E-03 0,06749131 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 7,131E-03 0,06721471 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 7,131E-03 0,06694037 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 7,131E-03 0,06666825 ! nucleoside transport GO:0015858 6 5 0,000 7,131E-03 0,06639834 ! nucleoside salvage GO:0043174 7 5 0,000 7,131E-03 0,0661306 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 7,131E-03 0,06586502 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 7,131E-03 0,06560156 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 7,131E-03 0,0653402 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 7,131E-03 0,06508091 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 7,131E-03 0,06482367 ! early endosome to late endosome transport GO:0045022 11 5 0,000 7,131E-03 0,06456846 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 7,131E-03 0,06431525 ! depyrimidination GO:0045008 8 5 0,000 7,131E-03 0,06406402 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 7,131E-03 0,06381475 ! 5S class rRNA transcription GO:0042791 8 5 0,000 7,131E-03 0,0635674 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 7,131E-03 0,06332197 ! regulation of centrosome cycle GO:0046605 7 5 0,000 7,131E-03 0,06307842 ! neuronal ion channel clustering GO:0045161 7 5 0,000 7,131E-03 0,06283674 ! sodium ion homeostasis GO:0055078 6 5 0,000 7,131E-03 0,06259691 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 7,131E-03 0,0623589 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 7,131E-03 0,06212269 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 7,131E-03 0,06188826 ! monocyte differentiation GO:0030224 8 5 0,000 7,131E-03 0,0616556 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 7,131E-03 0,06142468 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 7,131E-03 0,06119548 ! centrosome duplication GO:0051298 5 5 0,000 7,131E-03 0,06096799 ! response to UV-C GO:0010225 6 5 0,000 7,131E-03 0,06074218 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 7,131E-03 0,06051804 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 7,131E-03 0,06029555 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 7,131E-03 0,06007469 ! regulation of dendrite development GO:0050773 12 5 0,000 7,131E-03 0,05985544 ! peptidyl-arginine modification GO:0018195 7 5 0,000 7,131E-03 0,05963778 ! positive regulation of organ growth GO:0046622 6 5 0,000 7,131E-03 0,0594217 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 7,131E-03 0,05920718 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 7,131E-03 0,05899421 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 7,131E-03 0,05878276 ! regulation of dopamine secretion GO:0014059 12 5 0,000 7,131E-03 0,05857282 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 7,131E-03 0,05836438 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 7,131E-03 0,05815741 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 7,131E-03 0,05795191 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 7,131E-03 0,05774785 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 7,131E-03 0,05754523 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 7,131E-03 0,05734402 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 7,131E-03 0,05714421 ! neural tube patterning GO:0021532 6 5 0,000 7,131E-03 0,0569458 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 7,131E-03 0,05674875 ! histone demethylation GO:0016577 9 5 0,000 7,131E-03 0,05655307 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 7,131E-03 0,05635873 ! regulation of sterol transport GO:0032371 7 5 0,000 7,131E-03 0,05616572 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 7,131E-03 0,05597403 ! enteric nervous system development GO:0048484 8 5 0,000 7,131E-03 0,05578364 ! establishment of planar polarity GO:0001736 6 5 0,000 7,131E-03 0,05559454 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 7,131E-03 0,05540672 ! muscle cell proliferation GO:0033002 8 5 0,000 7,131E-03 0,05522017 ! transcription termination GO:0006353 8 5 0,000 7,131E-03 0,05503486 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 7,131E-03 0,0548508 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 7,131E-03 0,05466797 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 7,131E-03 0,05448634 ! regulation of respiratory burst GO:0060263 8 5 0,000 7,131E-03 0,05430593 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 7,131E-03 0,0541267 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 7,131E-03 0,05394865 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 7,131E-03 0,05377177 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 7,131E-03 0,05359604 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 7,131E-03 0,05342146 ! apical protein localization GO:0045176 6 5 0,000 7,131E-03 0,05324802 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 7,131E-03 0,05307569 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 7,131E-03 0,05290448 ! galactolipid metabolic process GO:0019374 7 5 0,000 7,131E-03 0,05273437 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 7,131E-03 0,05256535 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 7,131E-03 0,05239741 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 7,131E-03 0,05223054 ! triglyceride catabolic process GO:0019433 6 5 0,000 7,131E-03 0,05206473 ! glial cell migration GO:0008347 10 5 0,000 7,131E-03 0,05189997 ! determination of adult lifespan GO:0008340 8 5 0,000 7,131E-03 0,05173624 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 7,131E-03 0,05157355 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 7,131E-03 0,05141188 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 7,131E-03 0,05125122 ! somatic stem cell maintenance GO:0035019 13 5 0,000 7,131E-03 0,05109156 ! cerebellar cortex formation GO:0021697 6 5 0,000 7,131E-03 0,05093289 ! neural plate development GO:0001840 6 5 0,000 7,131E-03 0,0507752 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 7,131E-03 0,05061849 ! regulation of sensory perception GO:0051931 6 5 0,000 7,131E-03 0,05046274 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 7,131E-03 0,05030794 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 7,131E-03 0,0501541 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 7,131E-03 0,05000119 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 7,131E-03 0,04984921 ! sensory cilium assembly GO:0035058 6 5 0,000 7,131E-03 0,04969815 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 7,131E-03 0,049548 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 7,131E-03 0,04939876 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 7,131E-03 0,04925042 ! spindle assembly GO:0051225 5 5 0,000 7,131E-03 0,04910296 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 7,131E-03 0,04895639 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 7,131E-03 0,04881068 ! protein amino acid prenylation GO:0018346 9 5 0,000 7,131E-03 0,04866584 ! organ regeneration GO:0031100 7 5 0,000 7,131E-03 0,04852186 ! NAD biosynthetic process GO:0009435 7 5 0,000 7,131E-03 0,04837873 ! carnitine metabolic process GO:0009437 5 5 0,000 7,131E-03 0,04823644 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 7,131E-03 0,04809498 ! cellular anion homeostasis GO:0030002 6 5 0,000 7,131E-03 0,04795436 GO:0055081|anion homeostasis, ! RNA localization GO:0006403 135 91 1,000 7,438E-03 0,04987267 ! response to oxidative stress GO:0006979 141 94 1,000 7,918E-03 0,0529406 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 8,246E-03 0,05497368 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 8,246E-03 0,0548148 ! tRNA transcription GO:0009304 11 6 0,000 8,551E-03 0,05667714 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 8,551E-03 0,05651428 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 8,551E-03 0,05635234 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 8,551E-03 0,05619134 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 8,551E-03 0,05603125 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 8,551E-03 0,05587207 ! regulation of helicase activity GO:0051095 11 6 0,000 8,551E-03 0,05571379 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 8,551E-03 0,05555641 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 8,551E-03 0,05539991 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 8,551E-03 0,05524429 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 8,551E-03 0,05508955 ! positive regulation of axon extension GO:0045773 8 6 0,000 8,551E-03 0,05493566 ! prostate gland development GO:0030850 9 6 0,000 8,551E-03 0,05478264 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 8,551E-03 0,05463047 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 8,551E-03 0,05447914 ! forebrain neuron differentiation GO:0021879 9 6 0,000 8,551E-03 0,05432864 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 8,551E-03 0,05417897 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 8,551E-03 0,05403013 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 8,551E-03 0,0538821 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 8,551E-03 0,05373488 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 8,551E-03 0,05358847 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 8,551E-03 0,05344285 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 8,551E-03 0,05329802 ! neuron adhesion GO:0007158 9 6 0,000 8,551E-03 0,05315397 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 8,551E-03 0,0530107 ! establishment of tissue polarity GO:0007164 7 6 0,000 8,551E-03 0,05286819 ! signal peptide processing GO:0006465 8 6 0,000 8,551E-03 0,05272646 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 8,551E-03 0,05258548 ! mRNA stabilization GO:0048255 15 6 0,000 8,551E-03 0,05244525 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 8,551E-03 0,05230577 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 8,551E-03 0,05216702 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 8,551E-03 0,05202902 ! opsonization GO:0008228 8 6 0,000 8,551E-03 0,05189174 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 8,551E-03 0,05175518 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 8,551E-03 0,05161934 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 8,551E-03 0,05148421 ! protein amino acid dealkylation GO:0008214 11 6 0,000 8,551E-03 0,05134979 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 8,551E-03 0,05121606 ! photoreceptor cell development GO:0042461 10 6 0,000 8,551E-03 0,05108303 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 8,551E-03 0,05095069 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 8,551E-03 0,05081904 ! mechanosensory behavior GO:0007638 8 6 0,000 8,551E-03 0,05068806 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 8,551E-03 0,05055776 ! negative regulation of endocytosis GO:0045806 8 6 0,000 8,551E-03 0,05042812 ! response to interferon-gamma GO:0034341 12 6 0,000 8,551E-03 0,05029915 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 8,551E-03 0,05017084 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 8,551E-03 0,05004318 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 8,551E-03 0,04991616 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 8,551E-03 0,04978979 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 8,551E-03 0,04966406 ! cGMP-mediated signaling GO:0019934 10 6 0,000 8,551E-03 0,04953896 ! activation of MAPKKK activity GO:0000185 10 6 0,000 8,551E-03 0,04941449 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 8,551E-03 0,04929065 ! thymic T cell selection GO:0045061 12 6 0,000 8,551E-03 0,04916742 ! protein lipoylation GO:0009249 10 6 0,000 8,551E-03 0,04904481 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 8,551E-03 0,04892281 ! pigment granule organization GO:0048753 11 6 0,000 8,551E-03 0,04880141 ! drug transport GO:0015893 6 6 0,000 8,551E-03 0,04868061 ! cysteine metabolic process GO:0006534 7 6 0,000 8,551E-03 0,04856041 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 8,551E-03 0,04844081 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 8,551E-03 0,04832179 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 8,551E-03 0,04820335 ! histidine metabolic process GO:0006547 6 6 0,000 8,551E-03 0,0480855 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 8,551E-03 0,04796821 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 8,551E-03 0,0478515 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 8,551E-03 0,04773536 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 8,551E-03 0,04761978 ! adenohypophysis development GO:0021984 10 6 0,000 8,551E-03 0,04750475 ! hyperosmotic response GO:0006972 8 6 0,000 8,551E-03 0,04739028 ! microtubule nucleation GO:0007020 10 6 0,000 8,551E-03 0,04727637 ! ER overload response GO:0006983 7 6 0,000 8,551E-03 0,04716299 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 8,551E-03 0,04705016 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 8,551E-03 0,04693787 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 8,551E-03 0,04682611 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 8,551E-03 0,04671489 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 8,551E-03 0,04660419 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 8,551E-03 0,04649401 ! response to dietary excess GO:0002021 7 6 0,000 8,551E-03 0,04638436 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 8,551E-03 0,04627522 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 8,551E-03 0,04616659 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 8,551E-03 0,04605847 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 8,551E-03 0,04595086 ! glycerol ether catabolic process GO:0044269 8 6 0,000 8,551E-03 0,04584375 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 8,551E-03 0,04573713 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 8,551E-03 0,04563102 ! neuron apoptosis GO:0051402 8 6 0,000 8,551E-03 0,04552539 ! organic alcohol transport GO:0015850 9 6 0,000 8,551E-03 0,04542025 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 8,551E-03 0,04531559 ! T cell mediated immunity GO:0002456 12 6 0,000 8,551E-03 0,04521142 ! male sex determination GO:0030238 9 6 0,000 8,551E-03 0,04510772 ! carnitine transport GO:0015879 8 6 0,000 8,551E-03 0,0450045 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 8,551E-03 0,04490175 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 8,551E-03 0,04479947 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 8,551E-03 0,04469765 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 8,551E-03 0,0445963 ! positive regulation of exocytosis GO:0045921 6 6 0,000 8,551E-03 0,0444954 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 8,551E-03 0,04439496 ! parturition GO:0007567 12 6 0,000 8,551E-03 0,04429497 ! negative regulation of translational initiation GO:0045947 7 6 0,000 8,551E-03 0,04419543 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 8,551E-03 0,04409634 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 8,551E-03 0,04399769 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 8,551E-03 0,04389948 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 8,551E-03 0,04380171 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 8,551E-03 0,04370437 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 8,551E-03 0,04360747 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 8,551E-03 0,04351099 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 8,551E-03 0,04341494 ! macrophage differentiation GO:0030225 10 6 0,000 8,551E-03 0,04331931 ! astrocyte development GO:0014002 14 6 0,000 8,551E-03 0,04322411 ! hyaluronan metabolic process GO:0030212 6 6 0,000 8,551E-03 0,04312932 ! purine base biosynthetic process GO:0009113 14 6 0,000 8,551E-03 0,04303494 ! interaction with symbiont GO:0051702 8 6 0,000 8,551E-03 0,04294098 ! anterograde axon cargo transport GO:0008089 8 6 0,000 8,551E-03 0,04284742 ! skeletal muscle contraction GO:0003009 6 6 0,000 8,551E-03 0,04275428 ! eating behavior GO:0042755 6 6 0,000 8,551E-03 0,04266154 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 8,551E-03 0,04256919 ! response to copper ion GO:0046688 9 6 0,000 8,551E-03 0,04247725 ! DNA topological change GO:0006265 8 6 0,000 8,551E-03 0,04238571 ! response to exogenous dsRNA GO:0043330 8 6 0,000 8,551E-03 0,04229455 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 8,551E-03 0,04220379 ! establishment of melanosome localization GO:0032401 9 6 0,000 8,551E-03 0,04211342 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 8,551E-03 0,04202344 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 8,551E-03 0,04193383 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 8,551E-03 0,04184461 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 8,551E-03 0,04175577 ! nucleoside catabolic process GO:0009164 6 6 0,000 8,551E-03 0,0416673 ! gas homeostasis GO:0033483 11 6 0,000 8,551E-03 0,04157921 ! hair follicle maturation GO:0048820 7 6 0,000 8,551E-03 0,04149149 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 8,551E-03 0,04140414 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 8,551E-03 0,04131716 ! Schwann cell development GO:0014044 14 6 0,000 8,551E-03 0,04123054 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 8,551E-03 0,04114428 ! dendrite morphogenesis GO:0048813 9 6 0,000 8,551E-03 0,04105839 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 8,551E-03 0,04097285 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 8,551E-03 0,04088767 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 8,551E-03 0,04080284 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 8,551E-03 0,04071836 ! histone ubiquitination GO:0016574 7 6 0,000 8,551E-03 0,04063423 ! regulation of meiosis GO:0040020 10 6 0,000 8,551E-03 0,04055045 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 8,551E-03 0,04046701 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 8,551E-03 0,04038392 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 8,551E-03 0,04030116 ! regulation of mast cell activation GO:0033003 6 6 0,000 8,551E-03 0,04021875 ! membrane to membrane docking GO:0022614 12 6 0,000 8,551E-03 0,04013667 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 8,551E-03 0,04005492 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 8,551E-03 0,03997351 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 8,551E-03 0,03989243 ! receptor internalization GO:0031623 9 6 0,000 8,551E-03 0,03981168 ! neutrophil homeostasis GO:0001780 6 6 0,000 8,551E-03 0,03973125 ! coenzyme A metabolic process GO:0015936 9 6 0,000 8,551E-03 0,03965114 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 8,551E-03 0,03957136 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 8,551E-03 0,0394919 ! protein deubiquitination GO:0016579 8 6 0,000 8,551E-03 0,03941276 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 8,551E-03 0,03933394 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 8,551E-03 0,03925542 ! peptidyl-histidine modification GO:0018202 9 6 0,000 8,551E-03 0,03917723 ! axonal fasciculation GO:0007413 9 6 0,000 8,551E-03 0,03909934 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 8,551E-03 0,03902176 ! thiamin metabolic process GO:0006772 6 6 0,000 8,551E-03 0,03894449 ! midbrain development GO:0030901 6 6 0,000 8,551E-03 0,03886753 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 8,551E-03 0,03879086 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 8,551E-03 0,0387145 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 8,551E-03 0,03863844 ! progesterone metabolic process GO:0042448 8 6 0,000 8,551E-03 0,03856268 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 8,551E-03 0,03848722 ! glycolipid catabolic process GO:0019377 13 6 0,000 8,551E-03 0,03841205 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 8,551E-03 0,03833717 ! positive regulation of glucose import GO:0046326 6 6 0,000 8,551E-03 0,03826258 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 8,551E-03 0,03818829 ! adult feeding behavior GO:0008343 6 6 0,000 8,551E-03 0,03811428 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 8,551E-03 0,03804056 ! blastocyst growth GO:0001832 15 6 0,000 8,551E-03 0,03796712 ! pigment granule transport GO:0051904 12 6 0,000 8,551E-03 0,03789397 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 8,551E-03 0,03782109 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 8,551E-03 0,0377485 ! catecholamine transport GO:0051937 7 6 0,000 8,551E-03 0,03767618 ! organ or tissue specific immune response GO:0002251 7 6 0,000 8,551E-03 0,03760415 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 8,551E-03 0,03753238 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 8,551E-03 0,03746089 ! negative regulation of B cell activation GO:0050869 9 6 0,000 8,551E-03 0,03738967 ! protein prenylation GO:0018342 10 6 0,000 8,551E-03 0,03731872 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 8,551E-03 0,03724805 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 8,551E-03 0,03717763 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 8,551E-03 0,03710749 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 8,551E-03 0,0370376 ! positive regulation of coagulation GO:0050820 11 6 0,000 8,551E-03 0,03696798 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 9,969E-03 0,04301887 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 9,969E-03 0,04293832 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 9,969E-03 0,04285806 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 9,969E-03 0,0427781 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 9,969E-03 0,04269844 ! synaptonemal complex assembly GO:0007130 10 7 0,000 9,969E-03 0,04261907 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 9,969E-03 0,04254 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 9,969E-03 0,04246122 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 9,969E-03 0,04238274 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 9,969E-03 0,04230454 ! reproductive behavior GO:0019098 12 7 0,000 9,969E-03 0,04222663 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 9,969E-03 0,04214901 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 9,969E-03 0,04207167 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 9,969E-03 0,04199462 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 9,969E-03 0,04191784 ! oligopeptide transport GO:0006857 11 7 0,000 9,969E-03 0,04184135 ! protein amino acid sulfation GO:0006477 9 7 0,000 9,969E-03 0,04176514 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 9,969E-03 0,0416892 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 9,969E-03 0,04161354 ! RNA methylation GO:0001510 11 7 0,000 9,969E-03 0,04153815 ! pericardium development GO:0060039 8 7 0,000 9,969E-03 0,04146304 ! macrophage chemotaxis GO:0048246 10 7 0,000 9,969E-03 0,0413882 ! fibril organization GO:0043206 13 7 0,000 9,969E-03 0,04131362 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 9,969E-03 0,04123932 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 9,969E-03 0,04116528 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 9,969E-03 0,04109151 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 9,969E-03 0,041018 ! lipoprotein transport GO:0042953 9 7 0,000 9,969E-03 0,04094475 ! cerebral cortex cell migration GO:0021795 11 7 0,000 9,969E-03 0,04087177 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 9,969E-03 0,04079904 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 9,969E-03 0,04072657 ! estrogen metabolic process GO:0008210 14 7 0,000 9,969E-03 0,04065436 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 9,969E-03 0,04058241 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 9,969E-03 0,04051071 ! chemosensory behavior GO:0007635 9 7 0,000 9,969E-03 0,04043926 ! microtubule bundle formation GO:0001578 8 7 0,000 9,969E-03 0,04036806 ! T-helper 1 type immune response GO:0042088 11 7 0,000 9,969E-03 0,04029712 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 9,969E-03 0,04022642 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 9,969E-03 0,04015597 ! leukocyte degranulation GO:0043299 10 7 0,000 9,969E-03 0,04008577 ! bile acid and bile salt transport GO:0015721 9 7 0,000 9,969E-03 0,04001581 ! reflex GO:0060004 12 7 0,000 9,969E-03 0,0399461 ! positive regulation of isotype switching GO:0045830 15 7 0,000 9,969E-03 0,03987663 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 9,969E-03 0,0398074 ! protein-cofactor linkage GO:0018065 13 7 0,000 9,969E-03 0,03973841 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 9,969E-03 0,03966965 ! glycerolipid catabolic process GO:0046503 9 7 0,000 9,969E-03 0,03960114 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 9,969E-03 0,03953286 ! spinal cord patterning GO:0021511 7 7 0,000 9,969E-03 0,03946482 ! hemoglobin metabolic process GO:0020027 10 7 0,000 9,969E-03 0,03939701 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 9,969E-03 0,03932943 ! adrenal gland development GO:0030325 17 7 0,000 9,969E-03 0,03926209 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 9,969E-03 0,03919497 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 9,969E-03 0,03912809 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 9,969E-03 0,03906143 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 9,969E-03 0,038995 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 9,969E-03 0,03892879 ! endosome organization GO:0007032 10 7 0,000 9,969E-03 0,03886281 ! thyroid hormone generation GO:0006590 11 7 0,000 9,969E-03 0,03879706 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 9,969E-03 0,03873152 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 9,969E-03 0,03866621 ! regulation of pigmentation during development GO:0048070 15 7 0,000 9,969E-03 0,03860111 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 9,969E-03 0,03853624 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 9,969E-03 0,03847158 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 9,969E-03 0,03840714 ! galactose metabolic process GO:0006012 10 7 0,000 9,969E-03 0,03834291 ! vesicle fusion GO:0006906 15 7 0,000 9,969E-03 0,0382789 ! intracellular pH reduction GO:0051452 10 7 0,000 9,969E-03 0,0382151 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 9,969E-03 0,03815151 ! organ growth GO:0035265 11 7 0,000 9,969E-03 0,03808814 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 9,969E-03 0,03802498 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 9,969E-03 0,03796202 ! Rac protein signal transduction GO:0016601 7 7 0,000 9,969E-03 0,03789927 ! retinol metabolic process GO:0042572 9 7 0,000 9,969E-03 0,03783673 ! behavioral fear response GO:0001662 13 7 0,000 9,969E-03 0,0377744 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 9,969E-03 0,03771227 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 9,969E-03 0,03765035 ! rRNA modification GO:0000154 12 7 0,000 9,969E-03 0,03758862 ! protein heterooligomerization GO:0051291 10 7 0,000 9,969E-03 0,0375271 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 9,969E-03 0,03746578 ! response to UV-B GO:0010224 11 7 0,000 9,969E-03 0,03740467 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 9,969E-03 0,03734375 ! protein retention in ER lumen GO:0006621 12 7 0,000 9,969E-03 0,03728302 ! intermediate filament organization GO:0045109 11 7 0,000 9,969E-03 0,0372225 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 9,969E-03 0,03716217 ! cardiac muscle cell development GO:0055013 9 7 0,000 9,969E-03 0,03710204 ! fibrinolysis GO:0042730 9 7 0,000 9,969E-03 0,0370421 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 9,969E-03 0,03698236 ! regulation of circadian rhythm GO:0042752 11 7 0,000 9,969E-03 0,0369228 ! B cell lineage commitment GO:0002326 17 7 0,000 9,969E-03 0,03686344 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 9,969E-03 0,03680427 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 9,969E-03 0,03674529 ! response to tropane GO:0014073 13 7 0,000 9,969E-03 0,0366865 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 9,969E-03 0,03662789 ! melanosome localization GO:0032400 10 7 0,000 9,969E-03 0,03656947 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 9,969E-03 0,03651124 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 9,969E-03 0,0364532 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 9,969E-03 0,03639533 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 9,969E-03 0,03633765 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 9,969E-03 0,03628016 ! mast cell activation GO:0045576 9 7 0,000 9,969E-03 0,03622284 ! multicellular organismal aging GO:0010259 11 7 0,000 9,969E-03 0,03616571 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 9,969E-03 0,03610876 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 9,969E-03 0,03605198 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 9,969E-03 0,03599538 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 9,969E-03 0,03593897 ! establishment of nucleus localization GO:0040023 13 7 0,000 9,969E-03 0,03588272 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 9,969E-03 0,03582666 ! T cell lineage commitment GO:0002360 12 7 0,000 9,969E-03 0,03577076 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 9,969E-03 0,03571505 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 9,969E-03 0,0356595 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 9,969E-03 0,03560413 ! regulation of lipid transport GO:0032368 13 7 0,000 9,969E-03 0,03554893 ! response to tumor cell GO:0002347 12 7 0,000 9,969E-03 0,0354939 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 9,969E-03 0,03543904 ! neuroblast proliferation GO:0007405 13 7 0,000 9,969E-03 0,03538435 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 9,969E-03 0,03532983 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 9,969E-03 0,03527548 ! peptidyl-threonine modification GO:0018210 18 7 0,000 9,969E-03 0,03522129 ! diuresis GO:0030146 12 7 0,000 9,969E-03 0,03516727 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 9,969E-03 0,03511342 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 9,969E-03 0,03505973 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 9,969E-03 0,0350062 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 9,969E-03 0,03495284 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 9,969E-03 0,03489964 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 9,969E-03 0,0348466 ! melanin biosynthetic process GO:0042438 8 7 0,000 9,969E-03 0,03479372 ! regulation of synaptogenesis GO:0051963 10 7 0,000 9,969E-03 0,034741 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 9,969E-03 0,03468844 ! dopamine biosynthetic process GO:0042416 15 7 0,000 9,969E-03 0,03463604 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 9,969E-03 0,0345838 ! lymph node development GO:0048535 9 7 0,000 9,969E-03 0,03453172 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 9,969E-03 0,03447979 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 9,969E-03 0,03442802 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 9,969E-03 0,0343764 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 9,969E-03 0,03432494 ! endosome to lysosome transport GO:0008333 10 7 0,000 9,969E-03 0,03427363 ! ATP catabolic process GO:0006200 10 7 0,000 9,969E-03 0,03422248 ! establishment of pigment granule localization GO:0051905 13 7 0,000 9,969E-03 0,03417148 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 9,969E-03 0,03412063 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 9,969E-03 0,03406993 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 9,969E-03 0,03401938 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 9,969E-03 0,03396898 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 9,969E-03 0,03391873 ! muscle adaptation GO:0043500 12 7 0,000 9,969E-03 0,03386863 ! amino sugar catabolic process GO:0046348 9 7 0,000 9,969E-03 0,03381867 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 9,969E-03 0,03376887 ! retina homeostasis GO:0001895 9 7 0,000 9,969E-03 0,03371921 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 9,969E-03 0,03366969 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 9,969E-03 0,03362032 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 9,969E-03 0,0335711 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 9,969E-03 0,03352202 ! behavioral response to nicotine GO:0035095 11 7 0,000 9,969E-03 0,03347308 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 9,969E-03 0,03342429 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 9,969E-03 0,03337563 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,01138551 0,03806202 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,01138551 0,03800678 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,01138551 0,0379517 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,01138551 0,03789678 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,01138551 0,03784201 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,01138551 0,03778741 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,01138551 0,03773296 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,01138551 0,03767867 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,01138551 0,03762453 ! phosphate transport GO:0006817 10 8 0,000 0,01138551 0,03757055 ! N-glycan processing GO:0006491 12 8 0,000 0,01138551 0,03751672 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,01138551 0,03746305 ! UTP metabolic process GO:0046051 8 8 0,000 0,01138551 0,03740953 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,01138551 0,03735617 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,01138551 0,03730295 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,01138551 0,03724989 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,01138551 0,03719698 ! succinate metabolic process GO:0006105 14 8 0,000 0,01138551 0,03714422 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,01138551 0,0370916 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,01138551 0,03703914 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,01138551 0,03698683 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,01138551 0,03693466 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,01138551 0,03688264 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,01138551 0,03683076 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,01138551 0,03677903 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01138551 0,03672745 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,01138551 0,03667601 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,01138551 0,03662472 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,01138551 0,03657356 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,01138551 0,03652256 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,01138551 0,03647169 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,01138551 0,03642096 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,01138551 0,03637038 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,01138551 0,03631993 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,01138551 0,03626963 ! astrocyte differentiation GO:0048708 16 8 0,000 0,01138551 0,03621946 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,01138551 0,03616944 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,01138551 0,03611955 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,01138551 0,0360698 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,01138551 0,03602018 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,01138551 0,0359707 ! melanin metabolic process GO:0006582 12 8 0,000 0,01138551 0,03592136 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,01138551 0,03587215 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,01138551 0,03582308 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,01138551 0,03577414 ! macrophage activation GO:0042116 12 8 0,000 0,01138551 0,03572534 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,01138551 0,03567667 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,01138551 0,03562813 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,01138551 0,03557972 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,01138551 0,03553144 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01138551 0,0354833 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,01138551 0,03543528 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,01138551 0,0353874 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,01138551 0,03533964 ! ruffle organization GO:0031529 11 8 0,000 0,01138551 0,03529201 ! osteoblast development GO:0002076 13 8 0,000 0,01138551 0,03524451 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,01138551 0,03519714 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,01138551 0,0351499 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,01138551 0,03510278 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,01138551 0,03505579 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,01138551 0,03500892 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,01138551 0,03496218 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,01138551 0,03491556 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,01138551 0,03486907 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,01138551 0,0348227 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,01138551 0,03477646 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,01138551 0,03473033 ! oligodendrocyte development GO:0014003 8 8 0,000 0,01138551 0,03468433 ! segment specification GO:0007379 10 8 0,000 0,01138551 0,03463846 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,01138551 0,0345927 ! cellular extravasation GO:0045123 11 8 0,000 0,01138551 0,03454706 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,01138551 0,03450154 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,01138551 0,03445615 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,01138551 0,03441087 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,01138551 0,03436571 ! snRNA metabolic process GO:0016073 10 8 0,000 0,01138551 0,03432067 GO:0016180|snRNA processing, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 0,000 0,01138551 0,03427575 ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,01138551 0,03423094 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,01138551 0,03418626 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,01138551 0,03414169 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,01138551 0,03409723 ! nucleosome disassembly GO:0006337 12 8 0,000 0,01138551 0,03405289 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,01138551 0,03400867 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,01138551 0,03396456 ! icosanoid secretion GO:0032309 12 8 0,000 0,01138551 0,03392056 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,01138551 0,03387668 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,01138551 0,03383291 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,01138551 0,03378925 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,01138551 0,03374571 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,01138551 0,03370228 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,01138551 0,03365896 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,01138551 0,03361575 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,01138551 0,03357266 ! sterol catabolic process GO:0016127 9 8 0,000 0,01138551 0,03352967 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,01138551 0,03348679 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,01138551 0,03344403 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,01138551 0,03340137 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,01138551 0,03335882 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,01138551 0,03331638 ! prophase GO:0051324 11 8 0,000 0,01138551 0,03327404 ! S phase GO:0051320 8 8 0,000 0,01138551 0,03323182 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,01138551 0,0331897 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,01138551 0,03314769 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,01138551 0,03310578 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,01138551 0,03306398 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,01138551 0,03302229 ! hormone catabolic process GO:0042447 13 8 0,000 0,01138551 0,0329807 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,01138551 0,03293921 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,01138551 0,03289783 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,01138551 0,03285655 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,01138551 0,03281538 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,01138551 0,03277431 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,01138551 0,03273334 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,01138551 0,03269247 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,01138551 0,03265171 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,01138551 0,03261105 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,01138551 0,03257049 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,01138551 0,03253003 ! lamellipodium assembly GO:0030032 9 8 0,000 0,01138551 0,03248967 ! regulation of embryonic development GO:0045995 16 8 0,000 0,01138551 0,03244941 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,01138551 0,03240925 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,01138551 0,03236919 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,01138551 0,03232923 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,01279992 0,03630063 ! regulation of developmental growth GO:0048638 13 9 0,000 0,01279992 0,03625592 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,01279992 0,03621133 ! telencephalon cell migration GO:0022029 16 9 0,000 0,01279992 0,03616684 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,01279992 0,03612247 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,01279992 0,0360782 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,01279992 0,03603404 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,01279992 0,03598999 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,01279992 0,03594604 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,01279992 0,03590221 ! GTP metabolic process GO:0046039 9 9 0,000 0,01279992 0,03585848 ! elastic fiber assembly GO:0048251 13 9 0,000 0,01279992 0,03581485 ! social behavior GO:0035176 14 9 0,000 0,01279992 0,03577134 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,01279992 0,03572793 ! artery development GO:0060840 19 9 0,000 0,01279992 0,03568462 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,01279992 0,03564142 ! regulation of glycolysis GO:0006110 15 9 0,000 0,01279992 0,03559832 ! response to pain GO:0048265 16 9 0,000 0,01279992 0,03555533 ! protein complex disassembly GO:0043241 17 9 0,000 0,01279992 0,03551244 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,01279992 0,03546965 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,01279992 0,03542697 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,01279992 0,03538439 ! lung alveolus development GO:0048286 17 9 0,000 0,01279992 0,03534191 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,01279992 0,03529953 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,01279992 0,03525726 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,01279992 0,03521508 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,01279992 0,03517301 ! ventral spinal cord development GO:0021517 11 9 0,000 0,01279992 0,03513104 ! protein targeting to ER GO:0045047 19 9 0,000 0,01279992 0,03508917 ! T cell selection GO:0045058 18 9 0,000 0,01279992 0,03504739 ! endoderm development GO:0007492 12 9 0,000 0,01279992 0,03500572 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,01279992 0,03496415 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,01279992 0,03492267 ! arginine catabolic process GO:0006527 10 9 0,000 0,01279992 0,03488129 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,01279992 0,03484001 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,01279992 0,03479883 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,01279992 0,03475775 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,01279992 0,03471676 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,01279992 0,03467587 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,01279992 0,03463507 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,01279992 0,03459437 ! mannose metabolic process GO:0006013 9 9 0,000 0,01279992 0,03455377 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,01279992 0,03451326 ! receptor clustering GO:0043113 15 9 0,000 0,01279992 0,03447285 ! epithelial cell development GO:0002064 10 9 0,000 0,01279992 0,03443253 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,01279992 0,0343923 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,01279992 0,03435217 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,01279992 0,03431213 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,01279992 0,03427219 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,01279992 0,03423234 ! motor axon guidance GO:0008045 14 9 0,000 0,01279992 0,03419258 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,01279992 0,03415291 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,01279992 0,03411334 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,01279992 0,03407385 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,01279992 0,03403446 ! blastoderm segmentation GO:0007350 11 9 0,000 0,01279992 0,03399516 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,01279992 0,03395595 ! DNA ligation GO:0006266 14 9 0,000 0,01279992 0,03391683 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,01279992 0,0338778 ! response to amine stimulus GO:0014075 13 9 0,000 0,01279992 0,03383886 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,01279992 0,03380001 ! erythrocyte development GO:0048821 11 9 0,000 0,01279992 0,03376125 ! renal water homeostasis GO:0003091 14 9 0,000 0,01279992 0,03372258 ! postreplication repair GO:0006301 11 9 0,000 0,01279992 0,03368399 ! mRNA cleavage GO:0006379 13 9 0,000 0,01279992 0,0336455 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,01279992 0,03360709 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,01279992 0,03356877 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,01279992 0,03353054 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,01279992 0,03349239 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,01279992 0,03345433 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,01279992 0,03341636 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,01279992 0,03337847 ! acid secretion GO:0046717 14 9 0,000 0,01279992 0,03334067 ! musculoskeletal movement GO:0050881 11 9 0,000 0,01279992 0,03330295 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,01279992 0,03326532 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,01279992 0,03322778 ! purine base metabolic process GO:0006144 18 9 0,000 0,01279992 0,03319032 ! oocyte differentiation GO:0009994 12 9 0,000 0,01279992 0,03315294 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,01279992 0,03311565 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,01279992 0,03307844 ! spleen development GO:0048536 15 9 0,000 0,01279992 0,03304131 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,01279992 0,03300427 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,01279992 0,03296731 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,01279992 0,03293044 ! detection of calcium ion GO:0005513 13 9 0,000 0,01279992 0,03289364 ! blastocyst formation GO:0001825 12 9 0,000 0,01279992 0,03285693 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,01279992 0,0328203 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,01279992 0,03278375 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,01279992 0,03274729 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,01279992 0,0327109 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,01279992 0,0326746 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,01279992 0,03263837 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,01279992 0,03260223 ! prepulse inhibition GO:0060134 14 9 0,000 0,01279992 0,03256616 ! embryonic placenta development GO:0001892 12 9 0,000 0,01279992 0,03253018 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,01279992 0,03249427 ! insulin secretion GO:0030073 17 9 0,000 0,01279992 0,03245845 ! sequestering of metal ion GO:0051238 11 9 0,000 0,01279992 0,0324227 ! response to nicotine GO:0035094 16 9 0,000 0,01279992 0,03238703 ! establishment of cell polarity GO:0030010 12 9 0,000 0,01279992 0,03235144 ! nucleus localization GO:0051647 15 9 0,000 0,01279992 0,03231593 ! regulation of synapse organization GO:0050807 12 9 0,000 0,01279992 0,03228049 ! localization within membrane GO:0051668 15 9 0,000 0,01279992 0,03224514 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,01421238 0,0357642 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,01421238 0,03572511 ! neuron fate specification GO:0048665 11 10 0,000 0,01421238 0,03568611 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,01421238 0,0356472 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,01421238 0,03560837 ! thyroid gland development GO:0030878 19 10 0,000 0,01421238 0,03556962 ! synapsis GO:0007129 13 10 0,000 0,01421238 0,03553096 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,01421238 0,03549238 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,01421238 0,03545388 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,01421238 0,03541547 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,01421238 0,03537714 ! sulfate transport GO:0008272 12 10 0,000 0,01421238 0,0353389 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,01421238 0,03530073 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,01421238 0,03526265 ! androgen metabolic process GO:0008209 13 10 0,000 0,01421238 0,03522466 ! phospholipid efflux GO:0033700 16 10 0,000 0,01421238 0,03518674 ! hippocampus development GO:0021766 19 10 0,000 0,01421238 0,0351489 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,01421238 0,03511115 ! blood vessel remodeling GO:0001974 21 10 0,000 0,01421238 0,03507348 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,01421238 0,03503588 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,01421238 0,03499837 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,01421238 0,03496094 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,01421238 0,03492359 ! pathogenesis GO:0009405 13 10 0,000 0,01421238 0,03488632 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,01421238 0,03484913 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,01421238 0,03481201 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,01421238 0,03477498 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,01421238 0,03473802 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,01421238 0,03470115 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,01421238 0,03466435 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,01421238 0,03462763 ! melanocyte differentiation GO:0030318 15 10 0,000 0,01421238 0,03459098 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,01421238 0,03455442 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,01421238 0,03451793 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,01421238 0,03448152 ! response to X-ray GO:0010165 16 10 0,000 0,01421238 0,03444518 ! B cell proliferation GO:0042100 14 10 0,000 0,01421238 0,03440893 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,01421238 0,03437274 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,01421238 0,03433664 ! forebrain cell migration GO:0021885 17 10 0,000 0,01421238 0,03430061 ! lipid digestion GO:0044241 15 10 0,000 0,01421238 0,03426465 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,01421238 0,03422877 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,01421238 0,03419297 ! entry into host cell GO:0030260 20 10 0,000 0,01421238 0,03415724 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,01421238 0,03412159 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,01421238 0,03408601 ! negative regulation of ossification GO:0030279 19 10 0,000 0,01421238 0,0340505 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,01421238 0,03401507 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,01421238 0,03397971 ! regulation of bone resorption GO:0045124 24 10 0,000 0,01421238 0,03394442 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,01421238 0,03390921 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,01421238 0,03387407 ! regulation of organ growth GO:0046620 11 10 0,000 0,01421238 0,03383901 ! response to dsRNA GO:0043331 18 10 0,000 0,01421238 0,03380401 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,01421238 0,03376909 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,01421238 0,03373424 ! embryonic axis specification GO:0000578 12 10 0,000 0,01421238 0,03369946 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,01421238 0,03366476 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,01421238 0,03363012 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,01421238 0,03359556 ! cranial nerve development GO:0021545 12 10 0,000 0,01421238 0,03356107 ! fucose catabolic process GO:0019317 16 10 0,000 0,01421238 0,03352665 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,01421238 0,0334923 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,01421238 0,03345801 ! protein sumoylation GO:0016925 12 10 0,000 0,01421238 0,0334238 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,01421238 0,03338966 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,01421238 0,03335559 ! zymogen activation GO:0031638 14 10 0,000 0,01421238 0,03332159 ! salivary gland development GO:0007431 22 10 0,000 0,01421238 0,03328766 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,01421238 0,03325379 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,01421238 0,03322 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,01421238 0,03318627 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,01421238 0,03315262 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,01421238 0,03311903 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,01421238 0,03308551 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,01421238 0,03305205 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,01421238 0,03301867 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,01421238 0,03298535 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,01421238 0,0329521 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,01421238 0,03291891 ! detection of bacterium GO:0016045 10 10 0,000 0,01421238 0,03288579 ! embryonic gut development GO:0048566 11 10 0,000 0,01421238 0,03285274 ! activation of innate immune response GO:0002218 10 10 0,000 0,01421238 0,03281976 GO:0002758|innate immune response-activating signal transduction, ! cardiac cell differentiation GO:0035051 16 10 0,000 0,01421238 0,03278684 ! developmental induction GO:0031128 13 10 0,000 0,01421238 0,03275399 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,01421238 0,0327212 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,01421238 0,03268848 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,01421238 0,03265582 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,01421238 0,03262323 ! rRNA transcription GO:0009303 17 11 0,000 0,01562291 0,03582521 ! respiratory burst GO:0045730 14 11 0,000 0,01562291 0,03578953 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,01562291 0,03575392 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,01562291 0,03571838 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,01562291 0,03568291 ! virus-host interaction GO:0019048 17 11 0,000 0,01562291 0,03564751 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,01562291 0,03561218 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,01562291 0,03557692 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,01562291 0,03554173 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,01562291 0,03550661 ! RNA polyadenylation GO:0043631 19 11 0,000 0,01562291 0,03547156 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,01562291 0,03543658 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,01562291 0,03540166 ! mating GO:0007618 14 11 0,000 0,01562291 0,03536682 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,01562291 0,03533204 ! T cell proliferation GO:0042098 20 11 0,000 0,01562291 0,03529734 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,01562291 0,0352627 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,01562291 0,03522812 ! bone resorption GO:0045453 16 11 0,000 0,01562291 0,03519362 ! regulated secretory pathway GO:0045055 14 11 0,000 0,01562291 0,03515919 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,01562291 0,03512482 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,01562291 0,03509051 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,01562291 0,03505628 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,01562291 0,03502211 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,01562291 0,03498801 ! syncytium formation GO:0006949 15 11 0,000 0,01562291 0,03495398 ! plasma membrane organization GO:0007009 18 11 0,000 0,01562291 0,03492001 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,01562291 0,0348861 ! focal adhesion formation GO:0048041 24 11 0,000 0,01562291 0,03485227 ! mitotic spindle organization GO:0007052 15 11 0,000 0,01562291 0,0348185 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,01562291 0,03478479 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,01562291 0,03475115 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,01562291 0,03471757 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,01562291 0,03468406 ! adult heart development GO:0007512 11 11 0,000 0,01562291 0,03465061 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,01562291 0,03461723 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,01562291 0,03458391 ! temperature homeostasis GO:0001659 16 11 0,000 0,01562291 0,03455066 ! L-glutamate transport GO:0015813 16 11 0,000 0,01562291 0,03451747 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,01562291 0,03448434 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,01562291 0,03445128 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,01562291 0,03441828 ! stem cell development GO:0048864 29 11 0,000 0,01562291 0,03438535 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,01562291 0,03435247 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,01562291 0,03431966 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,01562291 0,03428692 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,01562291 0,03425423 ! vasoconstriction GO:0042310 15 11 0,000 0,01562291 0,03422161 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,01562291 0,03418905 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,01562291 0,03415655 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,01562291 0,03412411 ! ribosome assembly GO:0042255 13 11 0,000 0,01562291 0,03409173 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,01562291 0,03405942 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,01562291 0,03402717 ! chromatin silencing GO:0006342 19 11 0,000 0,01562291 0,03399497 ! nucleosome positioning GO:0016584 13 11 0,000 0,01562291 0,03396284 ! T cell homeostasis GO:0043029 20 11 0,000 0,01562291 0,03393077 ! regulation of isotype switching GO:0045191 19 11 0,000 0,01562291 0,03389876 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,01562291 0,03386681 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,01562291 0,03383492 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,01562291 0,03380309 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,01562291 0,03377132 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,01562291 0,03373961 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,01562291 0,03370796 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,01562291 0,03367637 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,01562291 0,03364484 ! male genitalia development GO:0030539 13 11 0,000 0,01562291 0,03361337 ! cholesterol efflux GO:0033344 19 11 0,000 0,01562291 0,03358195 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,01562291 0,0335506 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,01562291 0,0335193 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,01562291 0,03348806 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,01562291 0,03345688 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,01562291 0,03342576 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,01562291 0,03339469 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,01562291 0,03336368 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,01562291 0,03333273 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,01562291 0,03330184 ! lysogeny GO:0030069 18 11 0,000 0,01562291 0,03327101 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,01562291 0,03324023 ! acrosome reaction GO:0007340 13 11 0,000 0,01562291 0,03320951 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,01562291 0,03317884 ! lactation GO:0007595 20 12 0,000 0,01703149 0,03613694 ! reproductive cellular process GO:0048610 14 12 0,000 0,01703149 0,03610363 ! tRNA modification GO:0006400 14 12 0,000 0,01703149 0,03607038 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,01703149 0,0360372 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,01703149 0,03600408 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,01703149 0,03597102 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,01703149 0,03593802 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,01703149 0,03590508 ! non-recombinational repair GO:0000726 19 12 0,000 0,01703149 0,0358722 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,01703149 0,03583938 ! peroxisomal transport GO:0043574 21 12 0,000 0,01703149 0,03580662 ! cartilage condensation GO:0001502 18 12 0,000 0,01703149 0,03577392 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,01703149 0,03574128 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,01703149 0,03570869 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,01703149 0,03567617 ! heart looping GO:0001947 15 12 0,000 0,01703149 0,03564371 ! palate development GO:0060021 15 12 0,000 0,01703149 0,03561131 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,01703149 0,03557896 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,01703149 0,03554668 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,01703149 0,03551445 ! arginine metabolic process GO:0006525 13 12 0,000 0,01703149 0,03548228 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,01703149 0,03545017 ! methionine metabolic process GO:0006555 13 12 0,000 0,01703149 0,03541812 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,01703149 0,03538612 ! Golgi organization GO:0007030 18 12 0,000 0,01703149 0,03535419 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,01703149 0,03532231 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,01703149 0,03529048 ! monoamine transport GO:0015844 13 12 0,000 0,01703149 0,03525872 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,01703149 0,03522701 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,01703149 0,03519536 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,01703149 0,03516377 ! L-amino acid transport GO:0015807 20 12 0,000 0,01703149 0,03513223 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,01703149 0,03510075 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,01703149 0,03506933 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,01703149 0,03503796 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,01703149 0,03500665 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,01703149 0,03497539 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,01703149 0,03494419 ! cerebellum development GO:0021549 13 12 0,000 0,01703149 0,03491305 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,01703149 0,03488196 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,01703149 0,03485092 ! histone acetylation GO:0016573 23 12 0,000 0,01703149 0,03481994 ! histone methylation GO:0016571 15 12 0,000 0,01703149 0,03478902 ! autonomic nervous system development GO:0048483 23 12 0,000 0,01703149 0,03475815 ! gland morphogenesis GO:0022612 23 12 0,000 0,01703149 0,03472734 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,01703149 0,03469658 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,01703149 0,03466587 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,01703149 0,03463522 ! response to gamma radiation GO:0010332 20 12 0,000 0,01703149 0,03460463 ! regulation of epidermis development GO:0045682 17 12 0,000 0,01703149 0,03457408 ! intestinal absorption GO:0050892 19 12 0,000 0,01703149 0,0345436 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,01703149 0,03451316 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,01703149 0,03448278 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,01703149 0,03445245 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,01703149 0,03442218 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,01703149 0,03439196 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,01703149 0,03436179 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,01703149 0,03433167 ! microspike assembly GO:0030035 23 12 0,000 0,01703149 0,03430161 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,01703149 0,0342716 ! response to cold GO:0009409 14 12 0,000 0,01703149 0,03424164 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,01843815 0,03703733 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,01843815 0,03700501 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,01843815 0,03697274 ! cGMP metabolic process GO:0046068 16 13 0,000 0,01843815 0,03694054 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,01843815 0,03690839 ! water transport GO:0006833 17 13 0,000 0,01843815 0,03687629 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,01843815 0,03684426 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,01843815 0,03681227 ! lipid localization GO:0010876 24 13 0,000 0,01843815 0,03678034 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,01843815 0,03674847 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,01843815 0,03671666 ! organelle fusion GO:0048284 28 13 0,000 0,01843815 0,03668489 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,01843815 0,03665319 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,01843815 0,03662154 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,01843815 0,03658994 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,01843815 0,03655839 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,01843815 0,03652691 ! response to hexose stimulus GO:0009746 19 13 0,000 0,01843815 0,03649547 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,01843815 0,03646409 ! glutamate metabolic process GO:0006536 18 13 0,000 0,01843815 0,03643276 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,01843815 0,03640149 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,01843815 0,03637027 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,01843815 0,03633911 ! NAD metabolic process GO:0019674 21 13 0,000 0,01843815 0,03630799 ! exocrine system development GO:0035272 27 13 0,000 0,01843815 0,03627694 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,01843815 0,03624593 ! bone mineralization GO:0030282 15 13 0,000 0,01843815 0,03621498 ! regulation of exocytosis GO:0017157 17 13 0,000 0,01843815 0,03618408 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,01843815 0,03615323 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,01843815 0,03612243 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,01843815 0,03609169 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,01843815 0,036061 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,01843815 0,03603036 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,01843815 0,03599978 ! genitalia development GO:0048806 15 13 0,000 0,01843815 0,03596924 ! regulation of cellular pH GO:0030641 20 13 0,000 0,01843815 0,03593876 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,01843815 0,03590833 ! cellular pigmentation GO:0033059 24 13 0,000 0,01843815 0,03587795 ! tissue regeneration GO:0042246 21 13 0,000 0,01843815 0,03584762 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,01843815 0,03581735 ! cofactor transport GO:0051181 19 13 0,000 0,01843815 0,03578712 ! NADP metabolic process GO:0006739 18 13 0,000 0,01843815 0,03575695 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,01843815 0,03572682 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,01843815 0,03569675 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,01843815 0,03566673 ! gas transport GO:0015669 18 13 0,000 0,01843815 0,03563675 ! regulation of RNA stability GO:0043487 28 13 0,000 0,01843815 0,03560683 ! heme biosynthetic process GO:0006783 20 13 0,000 0,01843815 0,03557696 ! regulation of axon extension GO:0030516 23 13 0,000 0,01843815 0,03554714 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,01843815 0,03551737 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,01843815 0,03548765 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,01843815 0,03545797 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,01843815 0,03542835 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,01843815 0,03539878 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,01843815 0,03536926 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,01984287 0,03803216 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,01984287 0,03800049 ! superoxide anion generation GO:0042554 18 14 0,000 0,01984287 0,03796888 ! neuron maturation GO:0042551 21 14 0,000 0,01984287 0,03793732 ! regulation of S phase GO:0033261 18 14 0,000 0,01984287 0,03790581 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,01984287 0,03787435 ! myotube differentiation GO:0014902 21 14 0,000 0,01984287 0,03784295 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,01984287 0,03781159 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,01984287 0,03778029 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,01984287 0,03774904 ! inositol metabolic process GO:0006020 20 14 0,000 0,01984287 0,03771785 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,01984287 0,0376867 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,01984287 0,0376556 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,01984287 0,03762456 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,01984287 0,03759357 ! gene silencing by RNA GO:0031047 20 14 0,000 0,01984287 0,03756263 ! response to cAMP GO:0051591 19 14 0,000 0,01984287 0,03753174 ! limbic system development GO:0021761 25 14 0,000 0,01984287 0,0375009 ! startle response GO:0001964 21 14 0,000 0,01984287 0,03747011 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,01984287 0,03743937 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,01984287 0,03740868 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,01984287 0,03737804 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,01984287 0,03734746 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,01984287 0,03731692 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,01984287 0,03728643 ! glycine metabolic process GO:0006544 22 14 0,000 0,01984287 0,03725599 ! pituitary gland development GO:0021983 23 14 0,000 0,01984287 0,03722561 ! cellular response to starvation GO:0009267 21 14 0,000 0,01984287 0,03719527 ! lysosomal transport GO:0007041 20 14 0,000 0,01984287 0,03716498 ! regulation of heart rate GO:0002027 23 14 0,000 0,01984287 0,03713474 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,01984287 0,03710455 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,01984287 0,03707441 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,01984287 0,03704431 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,01984287 0,03701427 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,01984287 0,03698427 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,01984287 0,03695433 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,01984287 0,03692443 ! axon cargo transport GO:0008088 27 14 0,000 0,01984287 0,03689458 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,01984287 0,03686478 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,01984287 0,03683502 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,01984287 0,03680532 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,01984287 0,03677566 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,01984287 0,03674605 ! mRNA splice site selection GO:0006376 26 14 0,000 0,01984287 0,03671649 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,01984287 0,03668697 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,01984287 0,0366575 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,01984287 0,03662808 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,01984287 0,03659871 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,01984287 0,03656939 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,01984287 0,03654011 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,01984287 0,03651087 ! muscle maintenance GO:0046716 19 14 0,000 0,01984287 0,03648169 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,01984287 0,03645255 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,01984287 0,03642346 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,01984287 0,03639441 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,01984287 0,03636541 ! cell killing GO:0001906 20 14 0,000 0,01984287 0,03633646 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,01984287 0,03630755 ! cilium assembly GO:0042384 20 14 0,000 0,01984287 0,03627869 ! peptide hormone secretion GO:0030072 23 14 0,000 0,01984287 0,03624988 ! metencephalon development GO:0022037 19 15 0,000 0,02124566 0,03878175 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,02124566 0,038751 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,02124566 0,03872029 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,02124566 0,03868963 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,02124566 0,03865903 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,02124566 0,03862847 ! lipid phosphorylation GO:0046834 23 15 0,000 0,02124566 0,03859795 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,02124566 0,03856749 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,02124566 0,03853707 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,02124566 0,03850671 ! bile acid metabolic process GO:0008206 22 15 0,000 0,02124566 0,03847638 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,02124566 0,03844611 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,02124566 0,03841589 ! adult walking behavior GO:0007628 25 15 0,000 0,02124566 0,03838571 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,02124566 0,03835558 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,02124566 0,0383255 ! myoblast differentiation GO:0045445 27 15 0,000 0,02124566 0,03829546 ! centrosome cycle GO:0007098 16 15 0,000 0,02124566 0,03826547 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,02124566 0,03823553 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,02124566 0,03820564 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,02124566 0,03817579 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,02124566 0,03814599 ! cerebral cortex development GO:0021987 29 15 0,000 0,02124566 0,03811623 ! response to osmotic stress GO:0006970 22 15 0,000 0,02124566 0,03808652 ! vesicle coating GO:0006901 25 15 0,000 0,02124566 0,03805686 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,02124566 0,03802724 ! DNA integration GO:0015074 22 15 0,000 0,02124566 0,03799767 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,02124566 0,03796815 ! peptide secretion GO:0002790 27 15 0,000 0,02124566 0,03793867 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,02124566 0,03790924 ! regulation of vasodilation GO:0042312 24 15 0,000 0,02124566 0,03787985 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,02124566 0,03785051 ! neuron recognition GO:0008038 22 15 0,000 0,02124566 0,03782121 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,02124566 0,03779196 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,02124566 0,03776276 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,02124566 0,0377336 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,02124566 0,03770448 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,02124566 0,03767541 ! biomineral formation GO:0031214 18 15 0,000 0,02124566 0,03764639 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,02124566 0,0376174 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,02124566 0,03758847 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,02124566 0,03755958 ! dopamine metabolic process GO:0042417 30 15 0,000 0,02124566 0,03753073 ! organic cation transport GO:0015695 19 15 0,000 0,02124566 0,03750193 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,02124566 0,03747317 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,02124566 0,03744445 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,02124566 0,03741578 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,02124566 0,03738715 ! defense response to virus GO:0051607 27 15 0,000 0,02124566 0,03735857 ! peptide hormone processing GO:0016486 19 15 0,000 0,02124566 0,03733003 ! protein secretion GO:0009306 27 16 0,000 0,02264652 0,03976106 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,02264652 0,03973073 ! hormone secretion GO:0046879 25 16 0,000 0,02264652 0,03970045 ! bone remodeling GO:0046849 24 16 0,000 0,02264652 0,03967021 ! endothelial cell migration GO:0043542 22 16 0,000 0,02264652 0,03964002 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,02264652 0,03960988 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,02264652 0,03957978 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,02264652 0,03954973 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,02264652 0,03951972 ! glial cell development GO:0021782 24 16 0,000 0,02264652 0,03948976 ! patterning of blood vessels GO:0001569 24 16 0,000 0,02264652 0,03945984 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,02264652 0,03942997 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,02264652 0,03940015 ! protein polyubiquitination GO:0000209 26 16 0,000 0,02264652 0,03937036 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,02264652 0,03934063 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,02264652 0,03931094 ! fructose metabolic process GO:0006000 20 16 0,000 0,02264652 0,03928129 ! regulation of protein binding GO:0043393 27 16 0,000 0,02264652 0,03925169 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,02264652 0,03922213 ! protein export from nucleus GO:0006611 24 16 0,000 0,02264652 0,03919262 ! negative regulation of immune response GO:0050777 28 16 0,000 0,02264652 0,03916315 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,02264652 0,03913373 ! DNA replication initiation GO:0006270 25 16 0,000 0,02264652 0,03910435 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,02264652 0,03907501 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,02264652 0,03904572 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,02264652 0,03901647 ! diencephalon development GO:0021536 25 16 0,000 0,02264652 0,03898727 ! oogenesis GO:0048477 23 16 0,000 0,02264652 0,03895811 ! neural crest cell migration GO:0001755 24 16 0,000 0,02264652 0,03892899 ! G1 phase GO:0051318 27 16 0,000 0,02264652 0,03889992 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,02264652 0,03887089 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,02264652 0,0388419 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,02264652 0,03881296 ! steroid catabolic process GO:0006706 22 16 0,000 0,02264652 0,03878406 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,02264652 0,0387552 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,02264652 0,03872639 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,02264652 0,03869762 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,02264652 0,03866889 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,02264652 0,0386402 ! sperm-egg recognition GO:0035036 16 16 0,000 0,02264652 0,03861156 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,02264652 0,03858296 ! nerve development GO:0021675 18 16 0,000 0,02264652 0,0385544 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,02264652 0,03852588 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,02264652 0,03849741 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,02404546 0,04084531 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,02404546 0,04081516 ! negative regulation of defense response GO:0031348 19 17 0,000 0,02404546 0,04078506 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,02404546 0,04075501 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,02404546 0,040725 ! glycerol metabolic process GO:0006071 20 17 0,000 0,02404546 0,04069503 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,02404546 0,04066511 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,02404546 0,04063523 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,02404546 0,04060539 ! signal complex assembly GO:0007172 29 17 0,000 0,02404546 0,0405756 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,02404546 0,04054586 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,02404546 0,04051615 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,02404546 0,04048649 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,02404546 0,04045687 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,02404546 0,0404273 ! memory GO:0007613 25 17 0,000 0,02404546 0,04039777 ! keratinization GO:0031424 17 17 0,000 0,02404546 0,04036828 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,02404546 0,04033884 ! retinoid metabolic process GO:0001523 22 17 0,000 0,02404546 0,04030944 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,02404546 0,04028008 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,02404546 0,04025076 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,02404546 0,04022149 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,02404546 0,04019226 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,02404546 0,04016307 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,02404546 0,04013392 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,02404546 0,04010482 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,02404546 0,04007576 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,02404546 0,04004674 ! membrane budding GO:0006900 29 17 0,000 0,02404546 0,04001776 ! heme metabolic process GO:0042168 27 17 0,000 0,02404546 0,03998883 ! actin filament bundle formation GO:0051017 26 17 0,000 0,02404546 0,03995993 ! neuromuscular junction development GO:0007528 23 17 0,000 0,02404546 0,03993108 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,02404546 0,03990227 ! body fluid secretion GO:0007589 27 17 0,000 0,02404546 0,0398735 ! stem cell differentiation GO:0048863 36 17 0,000 0,02404546 0,03984477 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,02404546 0,03981609 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,02404546 0,03978744 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,02404546 0,03975884 ! sensory perception of pain GO:0019233 23 17 0,000 0,02404546 0,03973028 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,02404546 0,03970176 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,02404546 0,03967328 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,02404546 0,03964484 ! synaptogenesis GO:0007416 24 17 0,000 0,02404546 0,03961644 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,02404546 0,03958808 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,02404546 0,03955976 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,02404546 0,03953148 ! cell-cell junction organization GO:0045216 25 17 0,000 0,02404546 0,03950325 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,02404546 0,03947505 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,02404546 0,0394469 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,02404546 0,03941878 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,02404546 0,0393907 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,02404546 0,03936267 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,02404546 0,03933467 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,02544247 0,04159039 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,02544247 0,04156085 ! positive regulation of translation GO:0045727 28 18 0,000 0,02544247 0,04153136 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,02544247 0,0415019 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,02544247 0,04147249 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,02544247 0,04144312 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,02544247 0,04141379 ! cAMP metabolic process GO:0046058 33 18 0,000 0,02544247 0,0413845 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,02544247 0,04135525 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,02544247 0,04132605 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,02544247 0,04129688 ! axis specification GO:0009798 26 18 0,000 0,02544247 0,04126776 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,02544247 0,04123868 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,02544247 0,04120963 ! pancreas development GO:0031016 26 18 0,000 0,02544247 0,04118063 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,02544247 0,04115167 ! glutamine metabolic process GO:0006541 23 18 0,000 0,02544247 0,04112276 ! response to retinoic acid GO:0032526 25 18 0,000 0,02544247 0,04109388 ! pigmentation during development GO:0048066 31 18 0,000 0,02544247 0,04106504 ! central nervous system neuron development GO:0021954 30 18 0,000 0,02544247 0,04103624 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,02544247 0,04100749 ! fucose metabolic process GO:0006004 26 18 0,000 0,02544247 0,04097877 ! response to fungus GO:0009620 19 18 0,000 0,02544247 0,04095009 ! peptide cross-linking GO:0018149 31 18 0,000 0,02544247 0,04092146 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,02544247 0,04089286 ! heart process GO:0003015 27 18 0,000 0,02544247 0,0408643 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,02544247 0,04083579 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,02544247 0,04080731 ! visual learning GO:0008542 35 18 0,000 0,02544247 0,04077887 ! somitogenesis GO:0001756 24 18 0,000 0,02544247 0,04075047 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,02544247 0,04072212 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,02544247 0,0406938 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,02544247 0,04066552 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,02544247 0,04063728 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,02544247 0,04060908 ! vitamin transport GO:0051180 24 18 0,000 0,02544247 0,04058092 ! hormone transport GO:0009914 27 18 0,000 0,02544247 0,04055279 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,02544247 0,04052471 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,02544247 0,04049667 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,02544247 0,04046866 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,02544247 0,04044069 ! cell-cell recognition GO:0009988 20 18 0,000 0,02544247 0,04041276 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,02544247 0,04038487 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,02544247 0,04035702 ! regulation of glucose import GO:0046324 21 18 0,000 0,02544247 0,04032921 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,02544247 0,04030143 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,02544247 0,0402737 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,02544247 0,040246 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,02544247 0,04021834 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,02683757 0,04239451 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,02683757 0,04236541 ! positive regulation of ossification GO:0045778 30 19 0,000 0,02683757 0,04233635 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,02683757 0,04230733 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,02683757 0,04227836 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,02683757 0,04224942 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,02683757 0,04222052 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,02683757 0,04219166 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,02683757 0,04216284 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,02683757 0,04213406 ! regeneration GO:0031099 32 19 0,000 0,02683757 0,04210532 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,02683757 0,04207662 ! response to alkaloid GO:0043279 32 19 0,000 0,02683757 0,04204796 ! sensory perception of taste GO:0050909 23 19 0,000 0,02683757 0,04201933 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,02683757 0,04199075 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,02683757 0,0419622 ! smooth muscle contraction GO:0006939 36 19 0,000 0,02683757 0,0419337 ! peroxisome organization GO:0007031 29 19 0,000 0,02683757 0,04190523 ! digestive system process GO:0022600 30 19 0,000 0,02683757 0,0418768 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,02683757 0,04184841 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,02683757 0,04182005 ! response to vitamin A GO:0033189 26 19 0,000 0,02683757 0,04179174 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,02683757 0,04176346 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,02683757 0,04173523 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,02683757 0,04170703 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,02683757 0,04167887 ! response to starvation GO:0042594 30 19 0,000 0,02683757 0,04165074 ! sex determination GO:0007530 29 19 0,000 0,02683757 0,04162266 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,02683757 0,04159461 ! plasma membrane fusion GO:0045026 23 19 0,000 0,02683757 0,0415666 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,02683757 0,04153863 ! cytolysis GO:0019835 20 19 0,000 0,02683757 0,04151069 ! renal system process GO:0003014 35 19 0,000 0,02683757 0,0414828 ! vasodilation GO:0042311 33 19 0,000 0,02683757 0,04145494 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,02683757 0,04142711 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,02683757 0,04139933 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,02683757 0,04137158 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,02683757 0,04134387 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,02683757 0,0413162 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,02683757 0,04128856 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,02683757 0,04126096 ! sarcomere organization GO:0045214 23 19 0,000 0,02683757 0,0412334 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,02683757 0,04120587 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,02683757 0,04117839 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,02683757 0,04115093 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,02683757 0,04112352 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,02683757 0,04109614 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,02683757 0,0410688 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,02683757 0,04104149 ! protein stabilization GO:0050821 26 19 0,000 0,02683757 0,04101422 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,02823074 0,04311468 ! iron ion transport GO:0006826 37 20 0,000 0,02823074 0,04308607 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,02823074 0,0430575 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,02823074 0,04302897 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,02823074 0,04300047 ! response to vitamin GO:0033273 29 20 0,000 0,02823074 0,04297201 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,02823074 0,04294359 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,02823074 0,04291521 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,02823074 0,04288686 ! spinal cord development GO:0021510 31 20 0,000 0,02823074 0,04285855 ! response to ethanol GO:0045471 37 20 0,000 0,02823074 0,04283028 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,02823074 0,04280205 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,02823074 0,04277385 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,02823074 0,04274569 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,02823074 0,04271757 ! chromosome condensation GO:0030261 31 20 0,000 0,02823074 0,04268949 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,02823074 0,04266144 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,02823074 0,04263343 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,02823074 0,04260545 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,02823074 0,04257751 ! pallium development GO:0021543 38 20 0,000 0,02823074 0,04254961 ! DNA modification GO:0006304 28 20 0,000 0,02823074 0,04252175 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,02823074 0,04249392 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,02823074 0,04246613 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,02823074 0,04243837 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,02823074 0,04241065 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,02823074 0,04238297 ! collagen catabolic process GO:0030574 25 20 0,000 0,02823074 0,04235532 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,02823074 0,04232771 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,02823074 0,04230014 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,02823074 0,0422726 ! alditol metabolic process GO:0019400 24 20 0,000 0,02823074 0,04224509 ! actin filament-based movement GO:0030048 34 20 0,000 0,02823074 0,04221763 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,02962201 0,0442694 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,02962201 0,04424066 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,02962201 0,04421195 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,02962201 0,04418328 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,02962201 0,04415464 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,02962201 0,04412604 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,02962201 0,04409748 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,02962201 0,04406896 GO:0034105|positive regulation of tissue remodeling, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,02962201 0,04404047 ! protein amino acid acylation GO:0043543 37 21 0,000 0,02962201 0,04401202 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,02962201 0,04398361 ! vesicle docking GO:0048278 27 21 0,000 0,02962201 0,04395523 ! phototransduction GO:0007602 25 21 0,000 0,02962201 0,04392689 ! dendrite development GO:0016358 35 21 0,000 0,02962201 0,04389859 ! visual behavior GO:0007632 39 21 0,000 0,02962201 0,04387032 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,02962201 0,04384209 ! ovarian follicle development GO:0001541 30 21 0,000 0,02962201 0,0438139 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,02962201 0,04378574 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,02962201 0,04375762 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,02962201 0,04372953 ! cell aging GO:0007569 32 21 0,000 0,02962201 0,04370148 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,02962201 0,04367347 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,02962201 0,04364549 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,02962201 0,04361755 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,02962201 0,04358964 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,02962201 0,04356177 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,02962201 0,04353394 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,02962201 0,04350614 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,02962201 0,04347837 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,02962201 0,04345065 ! fatty acid transport GO:0015908 30 21 0,000 0,02962201 0,04342295 ! immunoglobulin production GO:0002377 33 21 0,000 0,02962201 0,04339529 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,02962201 0,04336767 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,02962201 0,04334008 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,02962201 0,04331253 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,02962201 0,04328501 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,02962201 0,04325753 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,02962201 0,04323008 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,02962201 0,04320267 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,02962201 0,04317529 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,02962201 0,04314795 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,02962201 0,04312064 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,02962201 0,04309337 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,02962201 0,04306613 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,02962201 0,04303892 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,02962201 0,04301175 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,03101136 0,04500071 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,03101136 0,04497233 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,03101136 0,04494399 ! viral genome replication GO:0019079 29 22 0,000 0,03101136 0,04491569 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,03101136 0,04488743 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,03101136 0,04485919 ! leukocyte adhesion GO:0007159 38 22 0,000 0,03101136 0,044831 ! molting cycle process GO:0022404 40 22 0,000 0,03101136 0,04480284 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,03101136 0,04477471 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,03101136 0,04474662 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,03101136 0,04471857 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,03101136 0,04469055 ! vasculogenesis GO:0001570 33 22 0,000 0,03101136 0,04466257 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,03101136 0,04463462 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,03101136 0,0446067 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,03101136 0,04457882 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,03101136 0,04455098 ! lysosome organization GO:0007040 37 22 0,000 0,03101136 0,04452317 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,03101136 0,0444954 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,03101136 0,04446766 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,03101136 0,04443995 ! regulation of behavior GO:0050795 38 22 0,000 0,03101136 0,04441228 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,03101136 0,04438464 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,03101136 0,04435704 ! membrane depolarization GO:0051899 35 22 0,000 0,03101136 0,04432947 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,03101136 0,04430194 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,03101136 0,04427444 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,03101136 0,04424697 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,03101136 0,04421954 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,03101136 0,04419214 ! blastocyst development GO:0001824 37 22 0,000 0,03101136 0,04416478 ! neural tube closure GO:0001843 33 22 0,000 0,03101136 0,04413745 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,03101136 0,04411015 ! protein tetramerization GO:0051262 39 22 0,000 0,03101136 0,04408289 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,0323988 0,0460267 ! neuron fate commitment GO:0048663 32 23 0,000 0,0323988 0,04599829 ! embryonic pattern specification GO:0009880 31 23 0,000 0,0323988 0,04596992 ! myelination GO:0042552 35 23 0,000 0,0323988 0,04594157 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,0323988 0,04591327 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,0323988 0,045885 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,0323988 0,04585676 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,0323988 0,04582856 ! vesicle targeting GO:0006903 32 23 0,000 0,0323988 0,04580039 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,0323988 0,04577226 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,0323988 0,04574416 ! osteoblast differentiation GO:0001649 40 23 0,000 0,0323988 0,04571609 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,0323988 0,04568806 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,0323988 0,04566007 ! interaction with host GO:0051701 37 23 0,000 0,0323988 0,04563211 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,0323988 0,04560418 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,0323988 0,04557629 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,0323988 0,04554843 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,0323988 0,04552061 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,0323988 0,04549282 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,0323988 0,04546506 ! cell fate determination GO:0001709 45 23 0,000 0,0323988 0,04543734 ! pentose metabolic process GO:0019321 31 23 0,000 0,0323988 0,04540965 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,0323988 0,04538199 ! spermatid development GO:0007286 33 23 0,000 0,0323988 0,04535437 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,0323988 0,04532678 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,0323988 0,04529923 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,0323988 0,04527171 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,0323988 0,04524422 ! telomere organization GO:0032200 32 23 0,000 0,0323988 0,04521677 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,0323988 0,04518935 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,0323988 0,04516196 ! regulation of amine transport GO:0051952 38 23 0,000 0,0323988 0,0451346 ! liver development GO:0001889 40 23 0,000 0,0323988 0,04510728 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,03378433 0,04700784 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,03378433 0,04697942 ! initiation of viral infection GO:0019059 42 24 0,000 0,03378433 0,04695103 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,03378433 0,04692268 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,03378433 0,04689436 ! superoxide metabolic process GO:0006801 32 24 0,000 0,03378433 0,04686608 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,03378433 0,04683783 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,03378433 0,04680961 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,03378433 0,04678143 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,03378433 0,04675329 ! sperm motility GO:0030317 27 24 0,000 0,03378433 0,04672517 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,03378433 0,04669709 ! vacuole organization GO:0007033 39 24 0,000 0,03378433 0,04666905 ! receptor metabolic process GO:0043112 37 24 0,000 0,03378433 0,04664103 ! neural crest cell development GO:0014032 39 24 0,000 0,03378433 0,04661305 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,03378433 0,04658511 ! primary neural tube formation GO:0014020 35 24 0,000 0,03378433 0,0465572 ! negative regulation of cell development GO:0010721 56 24 0,000 0,03378433 0,04652932 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,03378433 0,04650147 ! base-excision repair GO:0006284 31 24 0,000 0,03378433 0,04647366 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,03378433 0,04644588 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,03378433 0,04641814 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,03378433 0,04639042 ! glutathione metabolic process GO:0006749 29 24 0,000 0,03378433 0,04636274 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,03378433 0,0463351 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,03378433 0,04630749 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,03378433 0,0462799 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,03516796 0,04814661 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,03516796 0,04811797 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,03516796 0,04808936 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,03516796 0,04806079 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,03516796 0,04803225 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,03516796 0,04800374 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,03516796 0,04797527 ! peptide transport GO:0015833 43 25 0,000 0,03516796 0,04794683 ! male gonad development GO:0008584 33 25 0,000 0,03516796 0,04791843 ! iron ion homeostasis GO:0055072 39 25 0,000 0,03516796 0,04789006 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,03516796 0,04786172 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,03516796 0,04783342 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,03516796 0,04780515 ! phospholipid transport GO:0015914 35 25 0,000 0,03516796 0,04777691 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,03516796 0,0477487 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,03516796 0,04772053 ! detection of light stimulus GO:0009583 30 25 0,000 0,03516796 0,0476924 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,03516796 0,04766429 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,03516796 0,04763622 ! leukocyte proliferation GO:0070661 39 25 0,000 0,03516796 0,04760818 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,03516796 0,04758018 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,03654969 0,0494205 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,03654969 0,04939147 ! translational initiation GO:0006413 43 26 0,000 0,03654969 0,04936246 ! regulation of pH GO:0006885 36 26 0,000 0,03654969 0,0493335 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,03654969 0,04930456 ! circadian rhythm GO:0007623 42 26 0,000 0,03654969 0,04927566 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,03654969 0,04924679 ! post-embryonic development GO:0009791 42 26 0,000 0,03654969 0,04921796 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,03654969 0,04918916 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,03654969 0,0491604 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,03654969 0,04913166 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,03654969 0,04910297 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,03654969 0,0490743 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,03654969 0,04904567 ! regulation of coagulation GO:0050818 39 26 0,000 0,03654969 0,04901707 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,03792951 0,05083792 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,03792951 0,05080832 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,03792951 0,05077874 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,03792951 0,0507492 ! membrane docking GO:0022406 39 27 0,000 0,03792951 0,0507197 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,03792951 0,05069023 ! catechol metabolic process GO:0009712 43 27 0,000 0,03792951 0,05066079 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,03792951 0,05063139 ! acute-phase response GO:0006953 42 27 0,000 0,03792951 0,05060202 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,03792951 0,05057268 ! myofibril assembly GO:0030239 36 27 0,000 0,03792951 0,05054338 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,03792951 0,05051412 ! response to ionizing radiation GO:0010212 47 27 0,000 0,03792951 0,05048488 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,03792951 0,05045568 ! natural killer cell activation GO:0030101 35 27 0,000 0,03792951 0,05042652 ! lipid oxidation GO:0034440 38 27 0,000 0,03792951 0,05039739 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,03792951 0,05036829 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,03792951 0,05033923 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,03792951 0,0503102 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,03792951 0,0502812 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,03792951 0,05025223 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,03792951 0,0502233 ! gene silencing GO:0016458 41 27 0,000 0,03792951 0,05019441 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,03930744 0,05198799 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,03930744 0,05195811 ! phenol metabolic process GO:0018958 44 28 0,000 0,03930744 0,05192827 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,03930744 0,05189846 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,03930744 0,05186868 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,03930744 0,05183894 ! cell junction assembly GO:0034329 56 28 0,000 0,03930744 0,05180924 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,03930744 0,05177956 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,03930744 0,05174992 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,03930744 0,05172032 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,03930744 0,05169075 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,03930744 0,05166121 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,03930744 0,05163171 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,03930744 0,05160224 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,03930744 0,0515728 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,03930744 0,0515434 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,03930744 0,05151403 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,03930744 0,05148469 ! mesoderm formation GO:0001707 46 28 0,000 0,03930744 0,05145539 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,03930744 0,05142612 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,03930744 0,05139688 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,03930744 0,05136768 ! ensheathment of neurons GO:0007272 43 28 0,000 0,03930744 0,05133851 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,03930744 0,05130937 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,03930744 0,05128027 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,03930744 0,0512512 ! neural tube formation GO:0001841 41 28 0,000 0,03930744 0,05122216 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,03930744 0,05119316 ! placenta development GO:0001890 37 28 0,000 0,03930744 0,05116419 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,04068348 0,05292534 ! regulation of innate immune response GO:0045088 38 29 0,000 0,04068348 0,05289542 ! ovulation cycle process GO:0022602 41 29 0,000 0,04068348 0,05286554 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,04068348 0,05283568 ! protein targeting to membrane GO:0006612 53 29 0,000 0,04068348 0,05280587 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,04068348 0,05277608 ! mismatch repair GO:0006298 34 29 0,000 0,04068348 0,05274633 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,04068348 0,05271662 ! muscle cell development GO:0055001 38 29 0,000 0,04068348 0,05268694 ! formation of primary germ layer GO:0001704 48 29 0,000 0,04068348 0,05265729 ! telencephalon development GO:0021537 52 29 0,000 0,04068348 0,05262767 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,04068348 0,05259809 ! eye morphogenesis GO:0048592 51 29 0,000 0,04068348 0,05256854 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,04068348 0,05253902 ! tissue homeostasis GO:0001894 42 29 0,000 0,04068348 0,05250954 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,04205762 0,05425268 ! collagen metabolic process GO:0032963 40 30 0,000 0,04205762 0,05422227 ! organic anion transport GO:0015711 51 30 0,000 0,04205762 0,05419189 ! cholesterol transport GO:0030301 46 30 0,000 0,04205762 0,05416155 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,04205762 0,05413124 ! spliceosome assembly GO:0000245 49 30 0,000 0,04205762 0,05410097 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,04205762 0,05407072 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,04205762 0,05404052 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,04205762 0,05401034 ! ceramide metabolic process GO:0006672 43 30 0,000 0,04205762 0,0539802 ! ovulation cycle GO:0042698 43 30 0,000 0,04205762 0,0539501 ! hindbrain development GO:0030902 45 30 0,000 0,04205762 0,05392003 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,04205762 0,05388999 ! adult locomotory behavior GO:0008344 47 30 0,000 0,04205762 0,05385998 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,04205762 0,05383001 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,04205762 0,05380007 ! response to heat GO:0009408 41 30 0,000 0,04205762 0,05377016 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,04205762 0,05374029 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,04205762 0,05371045 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,04342987 0,05543214 ! negative regulation of secretion GO:0051048 49 31 0,000 0,04342987 0,05540139 ! mammary gland development GO:0030879 57 31 0,000 0,04342987 0,05537068 ! glial cell differentiation GO:0010001 55 31 0,000 0,04342987 0,05534 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,04342987 0,05530936 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,04342987 0,05527875 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,04342987 0,05524818 ! odontogenesis GO:0042476 50 31 0,000 0,04342987 0,05521764 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,04342987 0,05518713 ! segmentation GO:0035282 41 31 0,000 0,04342987 0,05515666 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,04342987 0,05512622 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,04342987 0,05509581 ! metanephros development GO:0001656 58 31 0,000 0,04342987 0,05506544 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,04342987 0,0550351 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,04342987 0,0550048 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,04342987 0,05497452 ! cell fate specification GO:0001708 37 31 0,000 0,04342987 0,05494428 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,04342987 0,05491408 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,04342987 0,05488391 ! RNA modification GO:0009451 40 31 0,000 0,04342987 0,05485377 ! regulation of muscle development GO:0048634 48 32 0,000 0,04480024 0,05655354 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,04480024 0,05652252 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,04480024 0,05649153 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,04480024 0,05646057 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,04480024 0,05642965 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,04480024 0,05639877 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,04480024 0,05636792 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,04480024 0,0563371 ! peripheral nervous system development GO:0007422 53 32 0,000 0,04480024 0,05630631 ! regulation of protein stability GO:0031647 48 32 0,000 0,04480024 0,05627556 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,04480024 0,05624484 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,04480024 0,05621416 ! cytokine production GO:0001816 44 32 0,000 0,04480024 0,05618351 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,04480024 0,05615289 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,04480024 0,0561223 ! vesicle localization GO:0051648 47 32 0,000 0,04480024 0,05609175 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,04616872 0,0577737 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,04616872 0,05774228 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,04616872 0,0577109 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,04616872 0,05767955 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,04616872 0,05764824 ! sister chromatid segregation GO:0000819 46 33 0,000 0,04616872 0,05761696 ! ear morphogenesis GO:0042471 42 33 0,000 0,04616872 0,05758571 ! actomyosin structure organization GO:0031032 43 33 0,000 0,04616872 0,0575545 ! cell junction organization GO:0034330 63 33 0,000 0,04616872 0,05752332 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,04616872 0,05749218 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,04616872 0,05746107 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,04616872 0,05742999 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,04616872 0,05739895 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,04616872 0,05736794 ! female gonad development GO:0008585 49 33 0,000 0,04616872 0,05733696 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,04616872 0,05730602 ! positive regulation of cell development GO:0010720 54 33 0,000 0,04616872 0,05727511 ! lipid homeostasis GO:0055088 55 33 0,000 0,04616872 0,05724423 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,04616872 0,05721339 ! regulation of proteolysis GO:0030162 50 33 0,000 0,04616872 0,05718258 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,04616872 0,05715181 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,04616872 0,05712106 ! cytokinesis GO:0000910 52 33 0,000 0,04616872 0,05709035 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,04616872 0,05705968 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,04753532 0,0587171 ! mRNA catabolic process GO:0006402 48 34 0,000 0,04753532 0,05868558 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,04753532 0,05865409 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,04753532 0,05862264 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,04753532 0,05859123 ! feeding behavior GO:0007631 45 34 0,000 0,04753532 0,05855985 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,04753532 0,0585285 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,04753532 0,05849718 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,04753532 0,0584659 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,04753532 0,05843465 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,04753532 0,05840344 ! neuron migration GO:0001764 46 34 0,000 0,04753532 0,05837225 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,04753532 0,05834111 ! female gamete generation GO:0007292 43 34 0,000 0,04753532 0,05830999 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,04753532 0,05827891 ! polyol metabolic process GO:0019751 44 34 0,000 0,04753532 0,05824786 ! aerobic respiration GO:0009060 47 34 0,000 0,04753532 0,05821684 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,04753532 0,05818586 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,04753532 0,05815491 ! embryonic organ development GO:0048568 45 34 0,000 0,04753532 0,05812399 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,04753532 0,05809311 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,04890004 0,0597292 ! Notch signaling pathway GO:0007219 56 35 0,000 0,04890004 0,0596975 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,04890004 0,05966583 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,04890004 0,05963419 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,04890004 0,05960259 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,04890004 0,05957102 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,04890004 0,05953948 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,04890004 0,05950798 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,04890004 0,05947651 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,04890004 0,05944508 ! glycogen metabolic process GO:0005977 48 35 0,000 0,04890004 0,05941367 ! pigment metabolic process GO:0042440 61 35 0,000 0,04890004 0,05938231 ! protein homooligomerization GO:0051260 52 35 0,000 0,04890004 0,05935097 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,05026288 0,0609729 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,05026288 0,06094076 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,05026288 0,06090865 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,05026288 0,06087658 ! negative regulation of binding GO:0051100 58 36 0,000 0,05026288 0,06084454 ! organic ether metabolic process GO:0018904 46 36 0,000 0,05026288 0,06081253 ! tissue remodeling GO:0048771 62 36 0,000 0,05026288 0,06078056 ! neural tube development GO:0021915 50 36 0,000 0,05026288 0,06074862 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,05026288 0,06071671 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,05026288 0,06068484 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,05026288 0,060653 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,05026288 0,0606212 ! glucan metabolic process GO:0044042 49 36 0,000 0,05026288 0,06058942 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,05162385 0,06219741 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,05162385 0,06216484 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,05162385 0,06213231 ! learning GO:0007612 67 37 0,000 0,05162385 0,06209981 ! ion transmembrane transport GO:0034220 56 37 0,000 0,05162385 0,06206735 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,05162385 0,06203492 ! regulation of protein secretion GO:0050708 51 37 0,000 0,05162385 0,06200253 ! amino acid activation GO:0043038 52 37 0,000 0,05162385 0,06197017 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,05162385 0,06193784 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,05298294 0,06353533 ! gliogenesis GO:0042063 71 38 0,000 0,05298294 0,06350222 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,05298294 0,06346915 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,05298294 0,06343611 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,05298294 0,0634031 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,05298294 0,06337013 ! phagocytosis GO:0006909 60 38 0,000 0,05298294 0,0633372 ! mesenchymal cell development GO:0014031 64 38 0,000 0,05298294 0,06330429 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,05298294 0,06327142 ! maintenance of location in cell GO:0051651 69 38 0,000 0,05298294 0,06323859 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,05434017 0,06482489 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,05434017 0,06479128 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,05434017 0,06475771 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,05434017 0,06472417 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,05434017 0,06469067 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,05434017 0,06465721 ! male sex differentiation GO:0046661 53 39 0,000 0,05434017 0,06462377 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,05434017 0,06459038 ! chromatin remodeling GO:0006338 68 39 0,000 0,05434017 0,06455701 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,05434017 0,06452369 ! JNK cascade GO:0007254 54 39 0,000 0,05434017 0,06449039 ! developmental growth GO:0048589 62 39 0,000 0,05434017 0,06445713 ! cell growth GO:0016049 61 39 0,000 0,05434017 0,06442391 ! synapse organization GO:0050808 55 39 0,000 0,05434017 0,06439072 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,05569552 0,06596277 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,05569552 0,06592882 ! regulation of tube size GO:0035150 60 40 0,000 0,05569552 0,06589491 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,05569552 0,06586103 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,05569552 0,06582718 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,05569552 0,06579338 ! peptide metabolic process GO:0006518 56 40 0,000 0,05569552 0,0657596 ! inner ear development GO:0048839 57 40 0,000 0,05569552 0,06572586 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,05569552 0,06569215 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,05569552 0,06565848 ! double-strand break repair GO:0006302 67 40 0,000 0,05569552 0,06562485 ! B cell differentiation GO:0030183 62 40 0,000 0,05569552 0,06559125 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,05569552 0,06555768 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,05569552 0,06552414 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,05569552 0,06549065 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,05704901 0,0670479 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,05704901 0,06701365 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,05704901 0,06697945 ! glucose transport GO:0015758 52 41 0,000 0,05704901 0,06694527 ! endosome transport GO:0016197 71 41 0,000 0,05704901 0,06691113 ! striated muscle contraction GO:0006941 62 41 0,000 0,05704901 0,06687703 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,05704901 0,06684296 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,05704901 0,06680893 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,05704901 0,06677493 ! biopolymer methylation GO:0043414 62 41 0,000 0,05704901 0,06674096 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,05704901 0,06670703 ! mitochondrial transport GO:0006839 60 42 0,000 0,05840064 0,06825279 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,05840064 0,06821812 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,05840064 0,06818349 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,05840064 0,0681489 ! cellular component disassembly GO:0022411 64 42 0,000 0,05840064 0,06811434 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,05840064 0,06807982 ! hexose transport GO:0008645 54 42 0,000 0,05840064 0,06804533 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,05840064 0,06801088 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,05840064 0,06797646 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,05840064 0,06794208 ! excretion GO:0007588 63 42 0,000 0,05840064 0,06790773 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,05840064 0,06787341 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,05840064 0,06783913 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,05840064 0,06780489 ! regulation of cell shape GO:0008360 78 42 0,000 0,05840064 0,06777068 ! positive regulation of binding GO:0051099 59 43 0,000 0,05975041 0,06930204 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,05975041 0,06926711 ! leukocyte migration GO:0050900 60 43 0,000 0,05975041 0,06923222 ! neuromuscular process GO:0050905 79 43 0,000 0,05975041 0,06919736 ! activation of caspase activity GO:0006919 65 43 0,000 0,05975041 0,06916253 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,05975041 0,06912774 ! tRNA processing GO:0008033 49 43 0,000 0,05975041 0,06909299 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,05975041 0,06905827 ! vesicle organization GO:0016050 79 43 0,000 0,05975041 0,06902358 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,05975041 0,06898893 ! methylation GO:0032259 64 43 0,000 0,05975041 0,06895432 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,06109833 0,0704745 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,06109833 0,07043917 ! glycolysis GO:0006096 53 44 0,000 0,06109833 0,07040388 ! regulation of action potential GO:0001508 71 44 0,000 0,06109833 0,07036863 ! regulation of ion transport GO:0043269 57 44 0,000 0,06109833 0,07033341 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,06109833 0,07029822 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,06109833 0,07026308 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,06109833 0,07022796 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,06109833 0,07019288 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,06109833 0,07015784 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,06109833 0,07012283 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,06109833 0,07008786 ! RNA catabolic process GO:0006401 64 45 0,000 0,06244438 0,07159625 ! positive regulation of defense response GO:0031349 59 45 0,000 0,06244438 0,07156058 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,06244438 0,07152494 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,06244438 0,07148934 ! cell recognition GO:0008037 58 45 0,000 0,06244438 0,07145377 ! cell maturation GO:0048469 60 45 0,000 0,06244438 0,07141824 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,06244438 0,07138274 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,06378859 0,07288314 ! cell redox homeostasis GO:0045454 63 46 0,000 0,06378859 0,07284695 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,06378859 0,07281079 ! regulation of ossification GO:0030278 71 46 0,000 0,06378859 0,07277468 ! histone modification GO:0016570 68 46 0,000 0,06378859 0,0727386 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,06378859 0,07270255 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,06513094 0,07419572 ! viral infectious cycle GO:0019058 71 47 0,000 0,06513094 0,07415899 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,06513094 0,0741223 ! endocrine system development GO:0035270 83 47 0,000 0,06513094 0,07408564 ! covalent chromatin modification GO:0016569 75 47 0,000 0,06513094 0,07404902 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,06513094 0,07401243 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,06513094 0,07397588 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,06513094 0,07393937 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,06513094 0,07390289 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,06513094 0,07386645 ! chloride transport GO:0006821 67 48 0,000 0,06647145 0,0753496 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,06647145 0,07531248 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,06647145 0,0752754 ! response to temperature stimulus GO:0009266 62 48 0,000 0,06647145 0,07523835 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,06647145 0,07520134 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,06647145 0,07516437 ! gastrulation GO:0007369 73 48 0,000 0,06647145 0,07512744 ! heart morphogenesis GO:0003007 65 48 0,000 0,06647145 0,07509054 ! regulation of DNA replication GO:0006275 75 48 0,000 0,06647145 0,07505367 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,06647145 0,07501685 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,06647145 0,07498005 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,06647145 0,0749433 ! regulation of endocytosis GO:0030100 63 48 0,000 0,06647145 0,07490658 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,06647145 0,0748699 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,06647145 0,07483325 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,06781011 0,07630296 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,06781011 0,07626565 ! sensory perception of smell GO:0007608 61 49 0,000 0,06781011 0,07622837 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,06781011 0,07619113 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,06781011 0,07615393 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,06781011 0,07611676 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,06781011 0,07607963 ! germ cell development GO:0007281 68 49 0,000 0,06781011 0,07604254 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,06781011 0,07600548 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,06781011 0,07596846 ! cartilage development GO:0051216 70 49 0,000 0,06781011 0,07593148 ! maintenance of location GO:0051235 84 49 0,000 0,06781011 0,07589453 ! regulation of actin filament length GO:0030832 72 50 0,000 0,06914693 0,07735308 ! ear development GO:0043583 72 50 0,000 0,06914693 0,07731547 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,06914693 0,07727791 ! membrane fusion GO:0006944 80 50 0,000 0,06914693 0,07724037 ! lipid modification GO:0030258 73 50 0,000 0,06914693 0,07720288 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,06914693 0,07716542 ! proton transport GO:0015992 75 50 0,000 0,06914693 0,077128 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,06914693 0,07709061 ! positive regulation of secretion GO:0051047 71 51 0,000 0,0704819 0,07854088 ! hydrogen transport GO:0006818 77 51 0,000 0,0704819 0,07850285 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,0704819 0,07846485 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,0704819 0,07842689 ! positive regulation of cell migration GO:0030335 92 51 0,000 0,0704819 0,07838897 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,0704819 0,07835108 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,0704819 0,07831323 ! adult behavior GO:0030534 80 51 0,000 0,0704819 0,07827541 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,0704819 0,07823764 ! transition metal ion transport GO:0000041 74 52 0,000 0,07181504 0,07967902 ! regulation of cellular component size GO:0032535 74 52 0,000 0,07181504 0,0796406 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,07181504 0,07960222 ! aging GO:0007568 79 52 0,000 0,07181504 0,07956387 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,07181504 0,07952557 ! establishment of organelle localization GO:0051656 85 52 0,000 0,07181504 0,0794873 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,07314635 0,08092188 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,07314635 0,08088298 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,07314635 0,08084411 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,07314635 0,08080528 ! kidney development GO:0001822 90 53 0,000 0,07314635 0,08076649 ! single fertilization GO:0007338 59 53 0,000 0,07314635 0,08072773 ! cell projection assembly GO:0030031 76 53 0,000 0,07314635 0,08068902 ! amino acid transport GO:0006865 84 54 0,000 0,07447582 0,08211619 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,07447582 0,08207685 ! regulation of mitosis GO:0007088 84 54 0,000 0,07447582 0,08203754 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,07447582 0,08199827 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,07447582 0,08195903 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,07447582 0,08191984 ! detection of external stimulus GO:0009581 66 54 0,000 0,07447582 0,08188068 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,07447582 0,08184156 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,07447582 0,08180247 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,07447582 0,08176343 ! exocytosis GO:0006887 74 55 0,000 0,07580346 0,08318127 ! mesoderm development GO:0007498 76 55 0,000 0,07580346 0,08314161 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,07580346 0,08310198 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,07580346 0,08306239 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,07712927 0,08447491 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,07712927 0,08443471 ! positive regulation of cell motion GO:0051272 99 56 0,000 0,07712927 0,08439454 ! carbohydrate transport GO:0008643 74 57 0,000 0,07845325 0,08580242 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,07845325 0,08576164 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,07845325 0,0857209 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,07845325 0,08568019 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,07845325 0,08563953 ! camera-type eye development GO:0043010 88 57 0,000 0,07845325 0,0855989 ! secondary metabolic process GO:0019748 84 57 0,000 0,07845325 0,08555831 ! developmental maturation GO:0021700 75 57 0,000 0,07845325 0,08551777 ! gonad development GO:0008406 79 57 0,000 0,07845325 0,08547725 ! viral reproductive process GO:0022415 87 58 0,000 0,07977542 0,08687664 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,07977542 0,08683552 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,07977542 0,08679444 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,07977542 0,08675341 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,08109576 0,08814756 ! activation of MAPK activity GO:0000187 84 59 0,000 0,08109576 0,08810592 ! lung development GO:0030324 94 59 0,000 0,08109576 0,08806432 ! actin filament organization GO:0007015 95 59 0,000 0,08109576 0,08802277 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,08109576 0,08798125 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,08109576 0,08793976 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,08241428 0,08932745 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,08241428 0,08928537 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,08241428 0,08924333 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,08241428 0,08920134 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,08241428 0,08915938 ! regulation of heart contraction GO:0008016 91 60 0,000 0,08241428 0,08911746 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,08241428 0,08907558 ! fertilization GO:0009566 68 60 0,000 0,08241428 0,08903374 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,08241428 0,08899194 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,08373098 0,09037131 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,08373098 0,09032892 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,08373098 0,09028657 ! urogenital system development GO:0001655 101 61 0,000 0,08373098 0,09024427 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,08373098 0,090202 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,08373098 0,09015977 ! extracellular matrix organization GO:0030198 103 61 0,000 0,08373098 0,09011758 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,08373098 0,09007543 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,08504588 0,09144718 ! neurotransmitter transport GO:0006836 81 62 0,000 0,08504588 0,09140445 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,08504588 0,09136175 ! respiratory tube development GO:0030323 99 62 0,000 0,08504588 0,0913191 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,08504588 0,09127649 ! organelle localization GO:0051640 96 62 0,000 0,08504588 0,09123391 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,08635896 0,09259935 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,08635896 0,0925562 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,08635896 0,09251309 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,08635896 0,09247002 ! viral reproduction GO:0016032 92 63 0,000 0,08635896 0,09242699 ! regulation of lipase activity GO:0060191 109 63 0,000 0,08635896 0,092384 ! appendage morphogenesis GO:0035107 93 64 0,000 0,08767023 0,09374315 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,08767023 0,09369959 ! hexose catabolic process GO:0019320 82 64 0,000 0,08767023 0,09365607 ! respiratory system development GO:0060541 100 64 0,000 0,08767023 0,09361259 ! adaptive immune response GO:0002250 94 64 0,000 0,08767023 0,09356915 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,08897969 0,09492268 ! appendage development GO:0048736 94 65 0,000 0,08897969 0,09487867 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,08897969 0,0948347 ! defense response to bacterium GO:0042742 73 65 0,000 0,08897969 0,09479078 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,08897969 0,09474689 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,08897969 0,09470305 ! activation of immune response GO:0002253 83 65 0,000 0,08897969 0,09465924 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,09028735 0,09600597 ! antigen processing and presentation GO:0019882 96 66 0,000 0,09028735 0,0959616 ! axon guidance GO:0007411 99 66 0,000 0,09028735 0,09591728 ! regulation of immune effector process GO:0002697 101 66 0,000 0,09028735 0,09587299 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,09159321 0,09721476 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,09159321 0,09716992 ! acute inflammatory response GO:0002526 92 68 0,000 0,09289727 0,09850793 ! learning or memory GO:0007611 123 68 0,000 0,09289727 0,09846254 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,09289727 0,09841719 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,09289727 0,09837187 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,09289727 0,0983266 ! rhythmic process GO:0048511 105 68 0,000 0,09289727 0,09828138 ! inorganic anion transport GO:0015698 93 68 0,000 0,09289727 0,09823619 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,09419953 0,09956751 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,09419953 0,09952178 ! response to drug GO:0042493 108 69 0,000 0,09419953 0,09947608 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,09549999 0,10080311 ! humoral immune response GO:0006959 86 70 0,000 0,09549999 0,10075687 ! eye development GO:0001654 111 70 0,000 0,09549999 0,10071067 ! amine transport GO:0015837 101 70 0,000 0,09549999 0,10066452 ! regulation of catabolic process GO:0009894 106 70 0,000 0,09549999 0,10061841 ! muscle cell differentiation GO:0042692 104 71 0,000 0,09679867 0,10193999 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,09679867 0,10189333 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,09679867 0,10184672 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,09679867 0,10180015 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,09679867 0,10175362 ! response to hypoxia GO:0001666 132 72 0,000 0,09809555 0,10306979 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,09809555 0,10302272 ! negative regulation of transport GO:0051051 116 73 0,000 0,09939064 0,10433523 ! regulation of blood pressure GO:0008217 107 73 0,000 0,09939064 0,10428763 ! tube morphogenesis GO:0035239 118 73 0,000 0,09939064 0,10424007 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,09939064 0,10419256 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,09939064 0,10414509 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,10068395 0,10545223 ! response to oxygen levels GO:0070482 137 74 0,000 0,10068395 0,10540423 ! digestion GO:0007586 97 74 0,000 0,10068395 0,10535628 ! protein import into nucleus GO:0006606 118 74 0,000 0,10068395 0,10530836 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,10068395 0,1052605 ! blood coagulation GO:0007596 116 75 0,000 0,10197548 0,10656229 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 0,000 0,10197548 0,1065139 ! nuclear import GO:0051170 121 75 0,000 0,10197548 0,10646555 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,10197548 0,10641724 ! amine biosynthetic process GO:0009309 97 76 0,000 0,10326523 0,1077143 ! tRNA metabolic process GO:0006399 95 76 0,000 0,10326523 0,10766547 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,10326523 0,10761668 ! regulation of protein transport GO:0051223 114 76 0,000 0,10326523 0,10756794 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,1045532 0,10886028 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,1045532 0,10881102 ! regulation of DNA binding GO:0051101 119 77 0,000 0,1045532 0,1087618 ! gland development GO:0048732 148 77 0,000 0,1045532 0,10871264 ! sex differentiation GO:0007548 105 77 0,000 0,1045532 0,10866351 ! protein ubiquitination GO:0016567 125 77 0,000 0,1045532 0,10861443 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,1045532 0,10856539 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,1045532 0,1085164 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,1045532 0,10846746 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,10583939 0,10975229 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,10583939 0,10970283 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,10712381 0,11098412 ! cellular respiration GO:0045333 107 79 0,000 0,10712381 0,11093415 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,10712381 0,11088423 ! T cell activation GO:0042110 134 79 0,000 0,10712381 0,11083435 ! regulation of lyase activity GO:0051339 133 79 0,000 0,10712381 0,11078451 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,10712381 0,11073472 ! chromatin assembly GO:0031497 102 80 0,000 0,10840645 0,11201026 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,10840645 0,11195996 ! protein localization in nucleus GO:0034504 133 80 0,000 0,10840645 0,11190971 ! forebrain development GO:0030900 131 80 0,000 0,10840645 0,11185951 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,10968733 0,11313043 ! hemostasis GO:0007599 125 81 0,000 0,10968733 0,11307972 ! mRNA transport GO:0051028 121 81 0,000 0,10968733 0,11302906 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,10968733 0,11297844 ! regulation of neurological system process GO:0031644 122 81 0,000 0,10968733 0,11292787 ! vitamin metabolic process GO:0006766 103 81 0,000 0,10968733 0,11287734 ! ossification GO:0001503 134 82 0,000 0,11096644 0,11414258 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,11096644 0,11409156 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,11224379 0,11535331 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,11224379 0,11530179 ! regulation of defense response GO:0031347 117 84 0,000 0,11351937 0,11656007 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,11351937 0,11650806 ! sterol metabolic process GO:0016125 120 84 0,000 0,11351937 0,11645609 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,1147932 0,11771037 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,1147932 0,11765791 ! rRNA metabolic process GO:0016072 107 85 0,000 0,1147932 0,1176055 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 0,000 0,1147932 0,11755314 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,1147932 0,11750083 ! regulation of protein localization GO:0032880 132 85 0,000 0,1147932 0,11744856 ! regulation of membrane potential GO:0042391 128 85 0,000 0,1147932 0,11739634 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,1147932 0,11734416 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,11606527 0,11859179 ! nucleosome organization GO:0034728 114 87 0,000 0,11733558 0,11983652 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,11733558 0,11978333 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,11733558 0,11973018 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,11733558 0,11967709 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,11733558 0,11962404 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,11733558 0,11957104 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,11860414 0,12081024 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,11860414 0,12075676 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,11860414 0,12070333 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,11860414 0,12064994 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,11987095 0,1218847 ! reproductive developmental process GO:0003006 127 89 0,000 0,11987095 0,12183084 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,11987095 0,12177703 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,11987095 0,12172326 ! regulation of T cell activation GO:0050863 128 89 0,000 0,11987095 0,12166954 ! leukocyte differentiation GO:0002521 143 90 0,000 0,12113601 0,12289935 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,12113601 0,12284516 ! hormone metabolic process GO:0042445 121 90 0,000 0,12113601 0,12279102 ! ATP metabolic process GO:0046034 137 91 0,000 0,12239933 0,12401694 ! response to virus GO:0009615 122 91 0,000 0,12239933 0,12396233 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,1236609 0,12518489 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,1236609 0,12512982 ! cell fate commitment GO:0045165 141 92 0,000 0,1236609 0,12507479 ! positive regulation of immune response GO:0050778 121 92 0,000 0,1236609 0,12501981 ! DNA recombination GO:0006310 146 92 0,000 0,1236609 0,12496488 ! sulfur metabolic process GO:0006790 118 92 0,000 0,1236609 0,12491 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,12492073 0,12612717 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,12492073 0,12607183 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,12492073 0,12601653 ! electron transport chain GO:0022900 123 94 0,000 0,12617883 0,12722986 ! regulation of binding GO:0051098 151 95 0,000 0,12743518 0,12844037 ! angiogenesis GO:0001525 149 95 0,000 0,12743518 0,12838411 ! carboxylic acid transport GO:0046942 147 95 0,000 0,12743518 0,1283279 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,12868981 0,1295346 ! in utero embryonic development GO:0001701 147 96 0,000 0,12868981 0,12947793 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,12868981 0,12942132 ! protein maturation GO:0051604 129 96 0,000 0,12868981 0,12936475 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,1299427 0,13056715 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,1299427 0,13051013 ! calcium ion transport GO:0006816 167 99 0,000 0,13244329 0,13296358 ! extracellular structure organization GO:0043062 156 99 0,000 0,13244329 0,13290557 ! protein import GO:0017038 156 99 0,000 0,13244329 0,13284761 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,133691 0,13404067 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,133691 0,13398227 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,133691 0,13392391 ! divalent metal ion transport GO:0070838 171 100 0,000 0,133691 0,13386561 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,133691 0,13380735 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,133691 0,13374915 ! protein localization in organelle GO:0033365 161 100 0,000 0,133691 0,133691