pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/901-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 6,000 1,879E-09 4,591E-06 ! filopodium assembly GO:0046847 42 17 3,000 4,166E-07 5,088E-04 ! muscle cell migration GO:0014812 8 5 2,000 4,979E-07 4,055E-04 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 2,000 4,979E-07 3,041E-04 ! microspike assembly GO:0030035 46 18 3,000 5,34E-07 2,609E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 4,000 7,94E-07 3,233E-04 ! nuclear migration GO:0007097 13 6 2,000 9,931E-07 3,466E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 9,931E-07 3,033E-04 GO:0031272|regulation of pseudopodium assembly, ! regulation of lipid kinase activity GO:0043550 17 8 2,000 2,766E-06 7,507E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 2,766E-06 6,756E-04 ! macrophage differentiation GO:0030225 15 9 2,000 4,137E-06 9,188E-04 ! positive regulation of B cell proliferation GO:0030890 18 10 2,000 5,894E-06 1,2E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 4,000 6,079E-06 1,142E-03 ! negative regulation of kinase activity GO:0033673 145 70 4,000 6,528E-06 1,139E-03 ! nucleus localization GO:0051647 22 11 2,000 8,082E-06 1,316E-03 ! negative regulation of transferase activity GO:0051348 155 74 4,000 8,585E-06 1,311E-03 ! regulation of B cell proliferation GO:0030888 22 12 2,000 1,075E-05 1,544E-03 ! regulation of cell projection assembly GO:0060491 33 12 2,000 1,075E-05 1,459E-03 ! T cell proliferation GO:0042098 32 12 2,000 1,075E-05 1,382E-03 ! response to hypoxia GO:0001666 178 81 4,000 1,337E-05 1,634E-03 ! response to oxygen levels GO:0070482 183 83 4,000 1,507E-05 1,753E-03 ! double-strand break repair GO:0006302 85 44 3,000 2,198E-05 2,441E-03 ! regulation of cell cycle process GO:0010564 161 90 4,000 2,234E-05 2,373E-03 ! induction of apoptosis by intracellular signals GO:0008629 95 45 3,000 2,406E-05 2,449E-03 ! regulation of DNA metabolic process GO:0051052 188 97 4,000 3,208E-05 3,135E-03 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 2,000 3,277E-05 3,079E-03 ! leukocyte differentiation GO:0002521 232 98 4,000 3,371E-05 3,05E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 4,000 3,371E-05 2,941E-03 ! DNA integration GO:0015074 32 18 2,000 3,922E-05 3,304E-03 ! response to UV GO:0009411 120 55 3,000 5,351E-05 4,358E-03 ! estrogen receptor signaling pathway GO:0030520 45 20 2,000 5,449E-05 4,294E-03 ! positive regulation of B cell activation GO:0050871 42 22 2,000 7,321E-05 5,589E-03 ! negative regulation of phosphorylation GO:0042326 52 24 2,000 9,57E-05 7,085E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 1,085E-04 7,793E-03 ! vasculogenesis GO:0001570 49 25 2,000 1,085E-04 7,57E-03 ! negative regulation of DNA replication GO:0008156 45 25 2,000 1,085E-04 7,36E-03 ! lymphocyte proliferation GO:0046651 55 25 2,000 1,085E-04 7,161E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 1,096E-04 7,044E-03 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 2,000 1,223E-04 7,659E-03 GO:0045936|negative regulation of phosphate metabolic process, ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 1,223E-04 7,468E-03 ! negative regulation of cell development GO:0010721 83 26 2,000 1,223E-04 7,285E-03 GO:0050768|negative regulation of neurogenesis, ! cell projection assembly GO:0030031 138 68 3,000 1,231E-04 7,16E-03 ! lung development GO:0030324 165 69 3,000 1,303E-04 7,403E-03 ! neuron fate determination GO:0048664 7 5 1,000 1,359E-04 7,544E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 1,359E-04 7,377E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 1,359E-04 7,216E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 1,359E-04 7,063E-03 ! negative regulation of T cell mediated immunity GO:0002710 15 5 1,000 1,359E-04 6,916E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mitotic recombination GO:0006312 9 5 1,000 1,359E-04 6,774E-03 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 1,000 1,359E-04 6,639E-03 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 1,000 1,359E-04 6,509E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 1,359E-04 6,384E-03 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 1,000 1,359E-04 6,263E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 1,000 1,359E-04 6,147E-03 ! retrograde protein transport, ER to cytosol GO:0030970 8 5 1,000 1,359E-04 6,035E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 1,372E-04 5,984E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 1,372E-04 5,88E-03 ! mitochondrial membrane organization GO:0007006 60 27 2,000 1,372E-04 5,778E-03 ! leukocyte proliferation GO:0070661 59 27 2,000 1,372E-04 5,68E-03 GO:0032943|mononuclear cell proliferation, ! cell cycle checkpoint GO:0000075 145 71 3,000 1,456E-04 5,929E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 1,456E-04 5,832E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 1,532E-04 6,038E-03 ! neuron fate commitment GO:0048663 52 28 2,000 1,532E-04 5,942E-03 ! respiratory tube development GO:0030323 171 72 3,000 1,537E-04 5,869E-03 ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 1,704E-04 6,406E-03 ! negative regulation of neuron differentiation GO:0045665 46 29 2,000 1,704E-04 6,309E-03 ! respiratory system development GO:0060541 175 74 3,000 1,71E-04 6,234E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 1,889E-04 6,785E-03 ! regulation of B cell activation GO:0050864 55 30 2,000 1,889E-04 6,687E-03 ! thymic T cell selection GO:0045061 16 6 1,000 2,033E-04 7,096E-03 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 1,000 2,033E-04 6,996E-03 ! protein import into mitochondrial inner membrane GO:0045039 9 6 1,000 2,033E-04 6,899E-03 ! negative regulation of gliogenesis GO:0014014 18 6 1,000 2,033E-04 6,804E-03 GO:0045686|negative regulation of glial cell differentiation, ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 2,033E-04 6,712E-03 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 2,085E-04 6,793E-03 ! T cell activation GO:0042110 189 84 3,000 2,786E-04 8,955E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 2,84E-04 9,009E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 2,84E-04 8,894E-03 ! mRNA stabilization GO:0048255 18 7 1,000 2,84E-04 8,781E-03 GO:0043489|RNA stabilization, ! positive regulation of isotype switching GO:0045830 17 7 1,000 2,84E-04 8,671E-03 GO:0045911|positive regulation of DNA recombination, ! induction of apoptosis by oxidative stress GO:0008631 9 7 1,000 2,84E-04 8,564E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 2,84E-04 8,46E-03 ! fibrinolysis GO:0042730 11 7 1,000 2,84E-04 8,358E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 2,84E-04 8,258E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 2,84E-04 8,161E-03 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 1,000 2,84E-04 8,066E-03 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 1,000 2,84E-04 7,974E-03 ! negative regulation of DNA metabolic process GO:0051053 65 35 2,000 3,004E-04 8,339E-03 ! mitochondrion organization GO:0007005 159 87 3,000 3,186E-04 8,747E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 3,777E-04 0,01025195 ! male meiosis GO:0007140 9 8 1,000 3,777E-04 0,01013929 ! T-helper 1 type immune response GO:0042088 12 8 1,000 3,777E-04 0,01002908 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 3,777E-04 9,921E-03 ! inner mitochondrial membrane organization GO:0007007 15 8 1,000 3,777E-04 9,816E-03 ! ER overload response GO:0006983 13 8 1,000 3,777E-04 9,712E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 3,777E-04 9,611E-03 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 3,777E-04 9,512E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 3,777E-04 9,415E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 3,777E-04 9,32E-03 ! response to tumor cell GO:0002347 16 8 1,000 3,777E-04 9,227E-03 ! B cell receptor signaling pathway GO:0050853 22 8 1,000 3,777E-04 9,135E-03 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 1,000 3,777E-04 9,046E-03 ! negative regulation of DNA replication initiation GO:0032297 10 8 1,000 3,777E-04 8,958E-03 GO:0000076|DNA replication checkpoint, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 3,777E-04 8,872E-03 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 3,84E-04 8,935E-03 ! DNA integrity checkpoint GO:0031570 82 38 2,000 3,84E-04 8,85E-03 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 3,84E-04 8,768E-03 ! positive regulation of leukocyte proliferation GO:0070665 70 39 2,000 4,149E-04 9,385E-03 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 4,813E-04 0,01078769 ! induction of positive chemotaxis GO:0050930 17 9 1,000 4,844E-04 0,01075827 ! T cell selection GO:0045058 27 9 1,000 4,844E-04 0,01066135 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 4,844E-04 0,01056616 ! regulation of Notch signaling pathway GO:0008593 24 9 1,000 4,844E-04 0,01047265 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 1,000 4,844E-04 0,01038079 GO:0002820|negative regulation of adaptive immune response, ! T cell differentiation GO:0030217 93 42 2,000 5,169E-04 0,01098159 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 6,04E-04 0,01272123 ! lung alveolus development GO:0048286 26 10 1,000 6,04E-04 0,0126125 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 6,04E-04 0,01250561 ! regulation of bone resorption GO:0045124 25 10 1,000 6,04E-04 0,01240052 ! regulation of gliogenesis GO:0014013 23 10 1,000 6,04E-04 0,01229719 GO:0045685|regulation of glial cell differentiation, ! regulation of B cell differentiation GO:0045577 24 10 1,000 6,04E-04 0,01219556 ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 6,04E-04 0,01209559 ! regulation of DNA replication initiation GO:0030174 14 10 1,000 6,04E-04 0,01199725 ! negative regulation of immune effector process GO:0002698 23 10 1,000 6,04E-04 0,0119005 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 6,04E-04 0,0118053 ! response to insulin stimulus GO:0032868 98 47 2,000 7,203E-04 0,0139665 ! neuron fate specification GO:0048665 18 11 1,000 7,365E-04 0,01416692 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 7,365E-04 0,01405624 ! blood vessel remodeling GO:0001974 30 11 1,000 7,365E-04 0,01394728 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 7,365E-04 0,01383999 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 7,365E-04 0,01373435 ! regulation of intracellular pH GO:0051453 21 11 1,000 7,365E-04 0,0136303 ! alpha-beta T cell activation GO:0046631 26 11 1,000 7,365E-04 0,01352781 ! positive regulation of T cell mediated immunity GO:0002711 26 11 1,000 7,365E-04 0,01342686 ! neuroblast proliferation GO:0007405 25 11 1,000 7,365E-04 0,0133274 ! regulation of isotype switching GO:0045191 24 11 1,000 7,365E-04 0,01322941 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 7,365E-04 0,01313284 ! T cell receptor signaling pathway GO:0050852 29 11 1,000 7,365E-04 0,01303768 ! mitochondrial transport GO:0006839 94 48 2,000 7,663E-04 0,0134678 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 8,141E-04 0,01420517 ! activation of caspase activity GO:0006919 95 50 2,000 8,637E-04 0,01496417 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 8,816E-04 0,01516752 GO:0050927|positive regulation of positive chemotaxis, ! hippocampus development GO:0021766 29 12 1,000 8,816E-04 0,01506145 ! ventral spinal cord development GO:0021517 25 12 1,000 8,816E-04 0,01495686 ! entry into host cell GO:0030260 34 12 1,000 8,816E-04 0,01485371 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 8,816E-04 0,01475197 ! peptidyl-lysine modification GO:0018205 21 12 1,000 8,816E-04 0,01465162 ! regulation of leukocyte migration GO:0002685 29 12 1,000 8,816E-04 0,01455262 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 8,816E-04 0,01445495 ! localization within membrane GO:0051668 26 12 1,000 8,816E-04 0,01435859 ! regulation of cell projection organization GO:0031344 135 51 2,000 9,152E-04 0,01480638 ! DNA-dependent DNA replication GO:0006261 82 52 2,000 9,686E-04 0,01556736 ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 1,024E-03 0,01634928 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 1,039E-03 0,01648829 GO:0000725|recombinational repair, ! response to X-ray GO:0010165 28 13 1,000 1,039E-03 0,01638192 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 1,039E-03 0,0162769 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 1,039E-03 0,01617323 ! regulation of mRNA stability GO:0043488 32 13 1,000 1,039E-03 0,01607087 ! regulation of DNA replication GO:0006275 105 56 2,000 1,202E-03 0,0184657 ! regulation of S phase GO:0033261 26 14 1,000 1,21E-03 0,01846997 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 1,000 1,21E-03 0,01835525 ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 1,21E-03 0,01824195 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 1,21E-03 0,01813003 ! regulation of cellular pH GO:0030641 27 14 1,000 1,21E-03 0,01801948 ! response to gamma radiation GO:0010332 30 14 1,000 1,21E-03 0,01791028 ! regulation of RNA stability GO:0043487 33 14 1,000 1,21E-03 0,01780238 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 1,21E-03 0,01769578 ! positive regulation of caspase activity GO:0043280 108 57 2,000 1,265E-03 0,0183976 GO:0010952|positive regulation of peptidase activity, ! positive regulation of cell migration GO:0030335 137 58 2,000 1,331E-03 0,01923427 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 1,392E-03 0,02000915 ! ER-associated protein catabolic process GO:0030433 24 15 1,000 1,392E-03 0,01989213 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! negative regulation of bone remodeling GO:0046851 34 15 1,000 1,392E-03 0,01977648 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 1,392E-03 0,01966217 ! G1/S transition checkpoint GO:0031575 37 15 1,000 1,392E-03 0,01954916 ! regulation of T cell mediated immunity GO:0002709 36 15 1,000 1,392E-03 0,01943746 ! establishment of organelle localization GO:0051656 122 59 2,000 1,398E-03 0,0194062 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 1,587E-03 0,02190987 ! pituitary gland development GO:0021983 30 16 1,000 1,587E-03 0,02178678 ! negative regulation of immune response GO:0050777 38 16 1,000 1,587E-03 0,02166507 ! DNA replication initiation GO:0006270 28 16 1,000 1,587E-03 0,0215447 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 1,587E-03 0,02142567 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 1,000 1,587E-03 0,02130795 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 1,587E-03 0,02119151 ! regulation of homeostatic process GO:0032844 148 62 2,000 1,613E-03 0,02142075 ! regulation of protein complex assembly GO:0043254 132 63 2,000 1,689E-03 0,0223099 ! regulation of mitosis GO:0007088 112 63 2,000 1,689E-03 0,02218996 GO:0051783|regulation of nuclear division, ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 1,768E-03 0,02309435 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 1,768E-03 0,02297151 ! positive regulation of cell killing GO:0031343 36 17 1,000 1,795E-03 0,02319812 ! auditory receptor cell differentiation GO:0042491 36 17 1,000 1,795E-03 0,02307603 ! DNA unwinding during replication GO:0006268 26 17 1,000 1,795E-03 0,02295521 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 1,000 1,795E-03 0,02283565 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of blood coagulation GO:0030195 25 17 1,000 1,795E-03 0,02271733 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 1,795E-03 0,02260023 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 1,000 1,795E-03 0,02248434 ! positive regulation of cell motion GO:0051272 157 65 2,000 1,848E-03 0,02303779 ! regulation of lipid metabolic process GO:0019216 132 66 2,000 1,931E-03 0,02394762 ! limbic system development GO:0021761 40 18 1,000 2,014E-03 0,02485114 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 2,014E-03 0,02472626 ! regulation of immunoglobulin production GO:0002637 49 18 1,000 2,014E-03 0,02460263 ! defense response to virus GO:0051607 43 18 1,000 2,014E-03 0,02448022 ! negative regulation of cell growth GO:0030308 142 67 2,000 2,016E-03 0,02438374 ! myeloid cell differentiation GO:0030099 126 67 2,000 2,016E-03 0,02426362 ! negative regulation of cell size GO:0045792 144 69 2,000 2,193E-03 0,02626513 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 2,000 2,193E-03 0,02613701 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 2,246E-03 0,02663137 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 2,246E-03 0,02650271 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 1,000 2,246E-03 0,0263753 ! proximal/distal pattern formation GO:0009954 33 19 1,000 2,246E-03 0,0262491 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 2,489E-03 0,02895635 ! protein amino acid acetylation GO:0006473 41 20 1,000 2,489E-03 0,02881911 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 2,489E-03 0,02868317 ! DNA duplex unwinding GO:0032508 30 20 1,000 2,489E-03 0,02854851 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 1,000 2,489E-03 0,02841511 GO:0030968|endoplasmic reticulum unfolded protein response, ! protein localization in mitochondrion GO:0070585 39 20 1,000 2,489E-03 0,02828294 GO:0006626|protein targeting to mitochondrion, ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 1,000 2,489E-03 0,028152 ! negative regulation of coagulation GO:0050819 30 20 1,000 2,489E-03 0,02802227 ! regulation of caspase activity GO:0043281 136 74 2,000 2,677E-03 0,03000228 ! organelle localization GO:0051640 155 74 2,000 2,677E-03 0,02986528 ! regulation of cell killing GO:0031341 46 21 1,000 2,744E-03 0,03047553 ! lipid phosphorylation GO:0046834 43 21 1,000 2,744E-03 0,03033763 ! ovarian follicle development GO:0001541 39 21 1,000 2,744E-03 0,03020097 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 2,744E-03 0,03006554 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 2,744E-03 0,02993132 ! diencephalon development GO:0021536 36 21 1,000 2,744E-03 0,02979829 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 2,744E-03 0,02966644 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 2,744E-03 0,02953575 ! lymphocyte differentiation GO:0030098 193 76 2,000 2,888E-03 0,03094251 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 2,997E-03 0,03197012 ! reciprocal meiotic recombination GO:0007131 44 22 1,000 3,012E-03 0,03198779 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 3,012E-03 0,03184932 ! cellular response to starvation GO:0009267 37 22 1,000 3,012E-03 0,03171203 ! cell aging GO:0007569 48 22 1,000 3,012E-03 0,03157593 ! positive regulation of locomotion GO:0040017 44 22 1,000 3,012E-03 0,03144099 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of adaptive immune response GO:0002821 42 22 1,000 3,012E-03 0,0313072 ! inner ear receptor cell differentiation GO:0060113 42 22 1,000 3,012E-03 0,03117454 ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 3,108E-03 0,03204021 ! blood coagulation GO:0007596 151 79 2,000 3,222E-03 0,03307584 GO:0050817|coagulation, ! protein oligomerization GO:0051259 149 79 2,000 3,222E-03 0,03293745 ! regulation of chemotaxis GO:0050920 45 23 1,000 3,29E-03 0,03349309 ! regulation of DNA recombination GO:0000018 51 23 1,000 3,29E-03 0,03335411 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 3,29E-03 0,03321628 ! meiosis GO:0007126 143 81 2,000 3,458E-03 0,03476429 GO:0051327|M phase of meiotic cell cycle, ! regulation of peptidase activity GO:0052547 150 82 2,000 3,58E-03 0,03584 ! meiotic cell cycle GO:0051321 144 82 2,000 3,58E-03 0,03569371 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 3,581E-03 0,03556034 ! mechanoreceptor differentiation GO:0042490 48 24 1,000 3,581E-03 0,03541638 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 3,581E-03 0,03527357 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 1,000 3,581E-03 0,03513191 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 1,000 3,581E-03 0,03499138 GO:0002708|positive regulation of lymphocyte mediated immunity, ! pallium development GO:0021543 56 24 1,000 3,581E-03 0,03485197 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 3,581E-03 0,03471367 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 3,883E-03 0,03749204 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 3,883E-03 0,03734444 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 3,883E-03 0,03719799 ! leukocyte adhesion GO:0007159 55 25 1,000 3,883E-03 0,03705268 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 3,883E-03 0,03690851 ! regulation of behavior GO:0050795 48 25 1,000 3,883E-03 0,03676545 ! regulation of alpha-beta T cell activation GO:0046634 48 25 1,000 3,883E-03 0,0366235 ! interaction with host GO:0051701 66 25 1,000 3,883E-03 0,03648264 ! immunoglobulin production GO:0002377 62 25 1,000 3,883E-03 0,03634286 GO:0002440|production of molecular mediator of immune response, ! liver development GO:0001889 55 25 1,000 3,883E-03 0,03620415 ! protein tetramerization GO:0051262 57 25 1,000 3,883E-03 0,03606649 ! hemostasis GO:0007599 165 85 2,000 3,96E-03 0,03664685 ! negative regulation of growth GO:0045926 168 85 2,000 3,96E-03 0,03650856 ! regulation of neuron differentiation GO:0045664 187 85 2,000 3,96E-03 0,03637131 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 3,96E-03 0,03623508 ! positive regulation of cell activation GO:0050867 161 86 2,000 4,092E-03 0,03730425 GO:0002696|positive regulation of leukocyte activation, ! initiation of viral infection GO:0019059 60 26 1,000 4,196E-03 0,038108 ! spinal cord development GO:0021510 54 26 1,000 4,196E-03 0,03796686 ! positive regulation of MAPKKK cascade GO:0043410 50 26 1,000 4,196E-03 0,03782676 ! regulation of blood coagulation GO:0030193 46 26 1,000 4,196E-03 0,03768769 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 4,521E-03 0,04045541 ! response to starvation GO:0042594 47 27 1,000 4,521E-03 0,04030776 ! cellular response to nutrient levels GO:0031669 45 27 1,000 4,521E-03 0,04016119 ! ossification GO:0001503 205 91 2,000 4,793E-03 0,04242531 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 4,857E-03 0,04283428 ! protein amino acid acylation GO:0043543 59 28 1,000 4,857E-03 0,0426802 ! negative regulation of protein modification process GO:0031400 66 28 1,000 4,857E-03 0,04252722 ! base-excision repair GO:0006284 41 28 1,000 4,857E-03 0,04237534 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 4,857E-03 0,04222454 ! bone development GO:0060348 206 92 2,000 4,941E-03 0,04280714 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 2,000 5,092E-03 0,04395952 GO:0010498|proteasomal protein catabolic process, ! positive regulation of MAP kinase activity GO:0043406 174 93 2,000 5,092E-03 0,04380473 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 5,204E-03 0,04460753 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 1,000 5,204E-03 0,04445156 ! somitogenesis GO:0001756 52 29 1,000 5,204E-03 0,04429668 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 5,403E-03 0,04582863 ! immune response-activating signal transduction GO:0002757 58 30 1,000 5,562E-03 0,04701824 GO:0002764|immune response-regulating signal transduction, ! cell fate determination GO:0001709 64 30 1,000 5,562E-03 0,04685611 ! regulation of coagulation GO:0050818 52 30 1,000 5,562E-03 0,04669509 ! forebrain development GO:0030900 210 98 2,000 5,889E-03 0,0492702 ! ovulation cycle process GO:0022602 55 31 1,000 5,931E-03 0,04945481 ! natural killer cell activation GO:0030101 50 31 1,000 5,931E-03 0,0492866 ! positive regulation of immune effector process GO:0002699 78 31 1,000 5,931E-03 0,04911952 ! positive regulation of T cell proliferation GO:0042102 60 32 1,000 6,311E-03 0,05209088 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 6,311E-03 0,05191549 ! ovulation cycle GO:0042698 57 32 1,000 6,311E-03 0,05174128 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 6,311E-03 0,05156823 ! regulation of pH GO:0006885 56 33 1,000 6,702E-03 0,05457997 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 6,702E-03 0,05439864 ! response to ionizing radiation GO:0010212 74 33 1,000 6,702E-03 0,05421851 ! negative regulation of protein transport GO:0051224 74 33 1,000 6,702E-03 0,05403957 ! regulation of ARF GTPase activity GO:0032312 73 34 1,000 7,104E-03 0,05708987 ! cell fate specification GO:0001708 56 34 1,000 7,104E-03 0,05690269 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 7,104E-03 0,05671673 ! DNA damage checkpoint GO:0000077 78 35 1,000 7,516E-03 0,05981331 ! telencephalon development GO:0021537 81 35 1,000 7,516E-03 0,05961911 ! calcium-mediated signaling GO:0019722 67 35 1,000 7,516E-03 0,05942617 ! protein targeting to membrane GO:0006612 75 36 1,000 7,939E-03 0,06256736 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 7,939E-03 0,06236618 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 8,373E-03 0,06555997 ! tissue remodeling GO:0048771 78 37 1,000 8,373E-03 0,06535051 ! female gonad development GO:0008585 71 37 1,000 8,373E-03 0,06514239 ! androgen receptor signaling pathway GO:0030521 81 37 1,000 8,373E-03 0,06493559 ! meiosis I GO:0007127 74 38 1,000 8,817E-03 0,06816128 ! spermatid development GO:0007286 69 38 1,000 8,817E-03 0,06794626 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 9,271E-03 0,07122153 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 1,000 9,271E-03 0,07099826 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 9,735E-03 0,07432173 GO:0046660|female sex differentiation, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,0102097 0,07770184 ! spermatid differentiation GO:0048515 73 41 1,000 0,0102097 0,07746053 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 0,01069434 0,08088626 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,01069434 0,08063661 ! regulation of T cell differentiation GO:0045580 78 42 1,000 0,01069434 0,0803885 ! cytokinesis GO:0000910 84 42 1,000 0,01069434 0,08014191 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,01118898 0,08359226 GO:0090047|positive regulation of transcription regulator activity, ! regulation of T cell proliferation GO:0042129 80 43 1,000 0,01118898 0,08333741 ! segmentation GO:0035282 78 43 1,000 0,01118898 0,0830841 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 1,000 0,01169354 0,08656763 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 0,01169354 0,08630609 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 0,01220795 0,08983136 ! B cell differentiation GO:0030183 124 45 1,000 0,01220795 0,0895616 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 1,000 0,01220795 0,08929345 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 0,01273212 0,09284944 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,01273212 0,0925731 ! positive regulation of cell cycle GO:0045787 96 48 1,000 0,01380944 0,10010819 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,01380944 0,09981201 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,01380944 0,09951758 ! regulation of adaptive immune response GO:0002819 92 48 1,000 0,01380944 0,09922488 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,01436243 0,10289568 ! JNK cascade GO:0007254 106 49 1,000 0,01436243 0,10259482 ! protein homooligomerization GO:0051260 84 49 1,000 0,01436243 0,10229571 ! endocrine system development GO:0035270 109 50 1,000 0,01492488 0,1059927 ! regulation of ARF protein signal transduction GO:0032012 115 50 1,000 0,01492488 0,10568547 ! viral infectious cycle GO:0019058 104 51 1,000 0,01549671 0,10941751 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,01549671 0,10910218 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,01549671 0,10878867 ! positive regulation of binding GO:0051099 88 52 1,000 0,01607783 0,11254483 ! Notch signaling pathway GO:0007219 111 52 1,000 0,01607783 0,11222327 ! histone modification GO:0016570 104 52 1,000 0,01607783 0,11190355 ! inner ear development GO:0048839 89 53 1,000 0,01666818 0,11568287 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,01666818 0,11535515 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,01726768 0,11916651 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 1,000 0,01726768 0,11883083 ! covalent chromatin modification GO:0016569 115 54 1,000 0,01726768 0,11849703 ! regulation of cell shape GO:0008360 142 54 1,000 0,01726768 0,11816511 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,01787625 0,12198795 ! cell maturation GO:0048469 107 55 1,000 0,01787625 0,12164815 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01843216 0,12508268 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01843216 0,12473619 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01843216 0,12439162 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01843216 0,12404894 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01843216 0,12370815 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01843216 0,12336922 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01843216 0,12303215 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01843216 0,12269691 ! polyol transport GO:0015791 12 5 0,000 0,01843216 0,12236349 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01843216 0,12203188 ! response to superoxide GO:0000303 10 5 0,000 0,01843216 0,12170207 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01843216 0,12137403 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01843216 0,12104776 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01843216 0,12072323 ! female meiosis GO:0007143 10 5 0,000 0,01843216 0,12040044 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01843216 0,12007937 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01843216 0,11976001 ! hypothalamus development GO:0021854 9 5 0,000 0,01843216 0,11944235 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01843216 0,11912636 ! cobalt ion transport GO:0006824 11 5 0,000 0,01843216 0,11881205 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01843216 0,11849938 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01843216 0,11818836 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01843216 0,11787897 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01843216 0,11757119 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01843216 0,11726501 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01843216 0,11696043 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01843216 0,11665742 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01843216 0,11635598 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01843216 0,1160561 ! transposition GO:0032196 9 5 0,000 0,01843216 0,11575775 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01843216 0,11546094 ! negative chemotaxis GO:0050919 16 5 0,000 0,01843216 0,11516564 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01843216 0,11487185 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01843216 0,11457956 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01843216 0,11428874 ! behavioral response to pain GO:0048266 10 5 0,000 0,01843216 0,11399941 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01843216 0,11371153 ! Notch receptor processing GO:0007220 11 5 0,000 0,01843216 0,1134251 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01843216 0,11314011 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01843216 0,11285655 ! micturition GO:0060073 9 5 0,000 0,01843216 0,11257441 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01843216 0,11229368 ! copulation GO:0007620 9 5 0,000 0,01843216 0,11201434 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01843216 0,11173639 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01843216 0,11145981 ! bioluminescence GO:0008218 9 5 0,000 0,01843216 0,11118461 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01843216 0,11091075 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01843216 0,11063824 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01843216 0,11036707 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01843216 0,11009723 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01843216 0,1098287 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01843216 0,10956147 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01843216 0,10929555 ! grooming behavior GO:0007625 6 5 0,000 0,01843216 0,10903091 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01843216 0,10876755 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01843216 0,10850546 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01843216 0,10824463 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01843216 0,10798505 ! response to protozoan GO:0001562 13 5 0,000 0,01843216 0,10772671 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,01843216 0,10746961 ! lymph vessel development GO:0001945 10 5 0,000 0,01843216 0,10721373 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01843216 0,10695906 ! endochondral ossification GO:0001958 17 5 0,000 0,01843216 0,1067056 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01843216 0,10645335 ! single strand break repair GO:0000012 8 5 0,000 0,01843216 0,10620228 ! parathyroid gland development GO:0060017 14 5 0,000 0,01843216 0,10595239 ! anagen GO:0042640 7 5 0,000 0,01843216 0,10570367 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01843216 0,10545612 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01843216 0,10520973 ! cytokine secretion GO:0050663 15 5 0,000 0,01843216 0,10496449 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01843216 0,10472038 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01843216 0,10447741 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01843216 0,10423557 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01843216 0,10399484 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01843216 0,10375522 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01843216 0,1035167 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01843216 0,10327928 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01843216 0,10304294 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01843216 0,10280768 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01843216 0,1025735 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01843216 0,10234038 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01843216 0,10210831 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01843216 0,1018773 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01843216 0,10164733 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01843216 0,10141839 ! microvillus organization GO:0032528 8 5 0,000 0,01843216 0,10119048 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01843216 0,1009636 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01843216 0,10073773 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01843216 0,10051287 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01843216 0,10028901 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01843216 0,10006614 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01843216 0,09984427 ! polyol catabolic process GO:0046174 9 5 0,000 0,01843216 0,09962337 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01843216 0,09940346 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01843216 0,0991845 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01843216 0,09896652 ! mitochondrial fission GO:0000266 8 5 0,000 0,01843216 0,09874948 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01843216 0,0985334 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01843216 0,09831826 ! mRNA transcription GO:0009299 10 5 0,000 0,01843216 0,09810406 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01843216 0,09789079 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01843216 0,09767845 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01843216 0,09746702 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01843216 0,09725651 ! monocyte activation GO:0042117 10 5 0,000 0,01843216 0,09704691 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01843216 0,0968382 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01843216 0,0966304 ! response to food GO:0032094 6 5 0,000 0,01843216 0,09642348 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01843216 0,09621745 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01843216 0,09601229 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01843216 0,09580801 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01843216 0,0956046 ! forebrain neuron development GO:0021884 13 5 0,000 0,01843216 0,09540204 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01843216 0,09520035 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01843216 0,0949995 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01843216 0,09479951 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01843216 0,09460035 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01843216 0,09440202 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01843216 0,09420453 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01843216 0,09400786 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01843216 0,09381201 ! lipid glycosylation GO:0030259 7 5 0,000 0,01843216 0,09361698 ! nucleobase transport GO:0015851 6 5 0,000 0,01843216 0,09342275 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01843216 0,09322933 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01843216 0,0930367 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01843216 0,09284488 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01843216 0,09265384 ! basic amino acid transport GO:0015802 12 5 0,000 0,01843216 0,09246358 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01843216 0,09227411 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01843216 0,09208541 ! actin nucleation GO:0045010 11 5 0,000 0,01843216 0,09189748 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01843216 0,09171032 ! depurination GO:0045007 5 5 0,000 0,01843216 0,09152391 ! depyrimidination GO:0045008 10 5 0,000 0,01843216 0,09133827 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01843216 0,09115337 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01843216 0,09096922 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01843216 0,09078582 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01843216 0,09060315 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01843216 0,09042122 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01843216 0,09024001 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01843216 0,09005953 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01843216 0,08987977 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01843216 0,08970073 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01843216 0,0895224 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01843216 0,08934477 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01843216 0,08916785 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01843216 0,08899163 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01843216 0,0888161 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01843216 0,08864127 ! response to arsenic GO:0046685 11 5 0,000 0,01843216 0,08846712 ! mast cell degranulation GO:0043303 7 5 0,000 0,01843216 0,08829366 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01843216 0,08812087 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01843216 0,08794876 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01843216 0,08777732 ! response to mercury ion GO:0046689 8 5 0,000 0,01843216 0,08760655 ! response to cadmium ion GO:0046686 7 5 0,000 0,01843216 0,08743644 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01843216 0,08726699 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01843216 0,08709819 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01843216 0,08693005 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01843216 0,08676255 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01843216 0,0865957 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01843216 0,08642949 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01843216 0,08626392 ! decidualization GO:0046697 11 5 0,000 0,01843216 0,08609898 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01843216 0,08593467 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01843216 0,08577098 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01843216 0,08560792 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01843216 0,08544547 ! embryonic cleavage GO:0040016 6 5 0,000 0,01843216 0,08528365 ! peroxisome fission GO:0016559 5 5 0,000 0,01843216 0,08512243 ! histone demethylation GO:0016577 13 5 0,000 0,01843216 0,08496182 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01843216 0,08480182 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01843216 0,08464242 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01843216 0,08448361 ! metaphase plate congression GO:0051310 7 5 0,000 0,01843216 0,0843254 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01843216 0,08416779 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01843216 0,08401076 ! enteric nervous system development GO:0048484 8 5 0,000 0,01843216 0,08385431 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01843216 0,08369845 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01843216 0,08354316 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01843216 0,08338845 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01843216 0,08323432 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01843216 0,08308075 ! B cell homeostasis GO:0001782 13 5 0,000 0,01843216 0,08292774 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01843216 0,0827753 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01843216 0,08262342 ! metaphase GO:0051323 11 5 0,000 0,01843216 0,0824721 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01843216 0,08232133 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01843216 0,0821711 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01843216 0,08202143 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01843216 0,0818723 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01843216 0,08172371 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01843216 0,08157566 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01843216 0,08142815 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01843216 0,08128116 ! response to redox state GO:0051775 6 5 0,000 0,01843216 0,08113471 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01843216 0,08098879 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01843216 0,08084338 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01843216 0,0806985 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01843216 0,08055414 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01843216 0,08041029 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01843216 0,08026696 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01843216 0,08012414 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01843216 0,07998182 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01843216 0,07984001 ! striatum development GO:0021756 14 5 0,000 0,01843216 0,0796987 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01843216 0,07955789 ! glial cell migration GO:0008347 10 5 0,000 0,01843216 0,07941758 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01843216 0,07927776 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01843216 0,07913843 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01843216 0,07899959 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01843216 0,07886123 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01843216 0,07872337 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01843216 0,07858598 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01843216 0,07844907 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01843216 0,07831264 ! neuroprotection GO:0043526 8 5 0,000 0,01843216 0,07817668 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01843216 0,07804119 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01843216 0,07790617 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01843216 0,07777162 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01843216 0,07763753 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01843216 0,0775039 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01843216 0,07737073 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01843216 0,07723802 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01843216 0,07710576 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01843216 0,07697396 GO:0060119|inner ear receptor cell development, ! spindle assembly GO:0051225 6 5 0,000 0,01843216 0,0768426 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01843216 0,0767117 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01843216 0,07658123 ! protein palmitoylation GO:0018345 12 5 0,000 0,01843216 0,07645121 ! drug metabolic process GO:0017144 7 5 0,000 0,01843216 0,07632164 ! stem cell division GO:0017145 11 5 0,000 0,01843216 0,0761925 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01843216 0,07606379 ! organ regeneration GO:0031100 7 5 0,000 0,01843216 0,07593552 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01843216 0,07580769 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01843216 0,07568028 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,01912032 0,07837407 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,01912032 0,07824279 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,01912032 0,07811195 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,01912032 0,07798154 ! aging GO:0007568 112 58 1,000 0,01975567 0,0804385 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,01975567 0,08030466 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,01975567 0,08017126 ! lipid modification GO:0030258 112 60 1,000 0,02105263 0,08529282 ! negative regulation of response to stimulus GO:0048585 106 61 1,000 0,02171409 0,08782703 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02207793 0,08915104 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02207793 0,08900392 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02207793 0,08885729 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02207793 0,08871115 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02207793 0,08856548 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02207793 0,08842029 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02207793 0,08827558 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02207793 0,08813133 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02207793 0,08798756 ! response to oxygen radical GO:0000305 11 6 0,000 0,02207793 0,08784426 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02207793 0,08770143 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02207793 0,08755905 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02207793 0,08741714 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02207793 0,08727569 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02207793 0,0871347 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02207793 0,08699416 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02207793 0,08685407 ! forebrain regionalization GO:0021871 9 6 0,000 0,02207793 0,08671443 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02207793 0,08657524 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02207793 0,0864365 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02207793 0,0862982 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02207793 0,08616035 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02207793 0,08602293 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02207793 0,08588595 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02207793 0,08574941 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02207793 0,0856133 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02207793 0,08547762 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02207793 0,08534237 ! malate metabolic process GO:0006108 13 6 0,000 0,02207793 0,08520755 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02207793 0,08507315 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02207793 0,08493918 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02207793 0,08480562 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02207793 0,08467249 ! protein refolding GO:0042026 15 6 0,000 0,02207793 0,08453978 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02207793 0,08440748 ! opsonization GO:0008228 8 6 0,000 0,02207793 0,08427559 ! mating behavior GO:0007617 7 6 0,000 0,02207793 0,08414411 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02207793 0,08401305 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02207793 0,08388239 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02207793 0,08375214 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02207793 0,08362229 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02207793 0,08349284 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02207793 0,0833638 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02207793 0,08323515 ! toxin metabolic process GO:0009404 11 6 0,000 0,02207793 0,0831069 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02207793 0,08297904 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02207793 0,08285158 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02207793 0,0827245 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02207793 0,08259782 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02207793 0,08247152 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02207793 0,08234561 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02207793 0,08222009 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02207793 0,08209494 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02207793 0,08197018 ! protein lipoylation GO:0009249 10 6 0,000 0,02207793 0,08184579 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02207793 0,08172178 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02207793 0,08159815 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02207793 0,08147489 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02207793 0,081352 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02207793 0,08122948 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02207793 0,08110733 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02207793 0,08098555 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02207793 0,08086413 ! hyperosmotic response GO:0006972 10 6 0,000 0,02207793 0,08074308 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02207793 0,08062239 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02207793 0,08050205 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02207793 0,08038208 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02207793 0,08026247 ! urea metabolic process GO:0019627 7 6 0,000 0,02207793 0,0801432 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02207793 0,0800243 ! neutrophil activation GO:0042119 7 6 0,000 0,02207793 0,07990574 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02207793 0,07978754 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02207793 0,07966969 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02207793 0,07955218 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02207793 0,07943502 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02207793 0,0793182 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02207793 0,07920173 ! neuron apoptosis GO:0051402 15 6 0,000 0,02207793 0,0790856 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02207793 0,0789698 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02207793 0,07885435 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02207793 0,07873924 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02207793 0,07862446 ! carnitine transport GO:0015879 10 6 0,000 0,02207793 0,07851001 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02207793 0,0783959 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02207793 0,07828211 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02207793 0,07816866 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02207793 0,07805554 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02207793 0,07794274 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02207793 0,07783027 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02207793 0,07771812 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02207793 0,0776063 ! establishment of spindle localization GO:0051293 16 6 0,000 0,02207793 0,07749479 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02207793 0,07738361 ! neural nucleus development GO:0048857 19 6 0,000 0,02207793 0,07727275 ! response to UV-C GO:0010225 14 6 0,000 0,02207793 0,0771622 ! astrocyte development GO:0014002 16 6 0,000 0,02207793 0,07705197 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02207793 0,07694205 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02207793 0,07683245 ! interaction with symbiont GO:0051702 14 6 0,000 0,02207793 0,07672315 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02207793 0,07661417 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02207793 0,0765055 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02207793 0,07639713 ! response to copper ion GO:0046688 10 6 0,000 0,02207793 0,07628908 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02207793 0,07618132 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02207793 0,07607387 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02207793 0,07596673 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02207793 0,07585988 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02207793 0,07575334 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02207793 0,07564709 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02207793 0,07554114 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02207793 0,07543549 ! hair follicle maturation GO:0048820 8 6 0,000 0,02207793 0,07533014 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02207793 0,07522507 ! Schwann cell development GO:0014044 15 6 0,000 0,02207793 0,0751203 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02207793 0,07501582 ! response to pheromone GO:0019236 6 6 0,000 0,02207793 0,07491163 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02207793 0,07480773 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02207793 0,07470412 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02207793 0,0746008 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02207793 0,07449776 ! subpallium development GO:0021544 15 6 0,000 0,02207793 0,074395 ! neural tube patterning GO:0021532 8 6 0,000 0,02207793 0,07429253 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02207793 0,07419034 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02207793 0,07408843 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02207793 0,0739868 ! G2 phase GO:0051319 16 6 0,000 0,02207793 0,07388545 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02207793 0,07378437 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02207793 0,07368357 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02207793 0,07358305 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02207793 0,0734828 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02207793 0,07338283 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02207793 0,07328312 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02207793 0,07318369 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02207793 0,07308452 ! receptor internalization GO:0031623 11 6 0,000 0,02207793 0,07298562 ! plasminogen activation GO:0031639 9 6 0,000 0,02207793 0,072887 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02207793 0,07278863 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02207793 0,07269053 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02207793 0,0725927 ! protein deubiquitination GO:0016579 16 6 0,000 0,02207793 0,07249513 ! protein destabilization GO:0031648 9 6 0,000 0,02207793 0,07239782 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02207793 0,07230077 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02207793 0,07220398 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02207793 0,07210746 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02207793 0,07201118 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02207793 0,07191517 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02207793 0,07181941 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02207793 0,07172391 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02207793 0,07162865 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02207793 0,07153366 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02207793 0,07143891 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02207793 0,07134441 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02207793 0,07125017 ! neural plate development GO:0001840 9 6 0,000 0,02207793 0,07115617 ! catecholamine transport GO:0051937 9 6 0,000 0,02207793 0,07106242 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02207793 0,07096892 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02207793 0,07087566 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02207793 0,07078265 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02207793 0,07068988 ! maternal placenta development GO:0001893 12 6 0,000 0,02207793 0,07059735 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02207793 0,07050507 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02207793 0,07041302 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02207793 0,07032122 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02207793 0,07022966 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02207793 0,07013833 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02207793 0,07004724 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02207793 0,06995639 GO:0055081|anion homeostasis, ! viral reproductive process GO:0022415 132 62 1,000 0,02238412 0,07083471 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,02238412 0,07074307 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,02444484 0,077156 GO:0048609|reproductive process in a multicellular organism, ! ear development GO:0043583 114 66 1,000 0,02514839 0,07927422 ! gonad development GO:0008406 115 66 1,000 0,02514839 0,07917207 ! tRNA transcription GO:0009304 17 7 0,000 0,02571026 0,08083675 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02571026 0,08073285 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02571026 0,08062921 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02571026 0,08052584 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02571026 0,08042274 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02571026 0,08031989 ! sleep GO:0030431 16 7 0,000 0,02571026 0,08021731 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02571026 0,080115 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02571026 0,08001294 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02571026 0,07991114 ! prostate gland development GO:0030850 14 7 0,000 0,02571026 0,0798096 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02571026 0,07970832 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02571026 0,0796073 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02571026 0,07950653 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02571026 0,07940601 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02571026 0,07930575 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02571026 0,07920575 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02571026 0,07910599 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02571026 0,07900649 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02571026 0,07890723 ! glycolipid transport GO:0046836 11 7 0,000 0,02571026 0,07880823 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02571026 0,07870947 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,02571026 0,07861096 ! neuron adhesion GO:0007158 14 7 0,000 0,02571026 0,0785127 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02571026 0,07841468 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02571026 0,0783169 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02571026 0,07821937 ! pericardium development GO:0060039 16 7 0,000 0,02571026 0,07812209 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02571026 0,07802504 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02571026 0,07792823 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,02571026 0,07783167 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02571026 0,07773534 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,02571026 0,07763925 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02571026 0,0775434 ! lipoprotein transport GO:0042953 14 7 0,000 0,02571026 0,07744779 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02571026 0,07735241 ! rhythmic behavior GO:0007622 17 7 0,000 0,02571026 0,07725727 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02571026 0,07716235 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02571026 0,07706768 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02571026 0,07697323 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02571026 0,07687902 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02571026 0,07678503 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02571026 0,07669128 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02571026 0,07659775 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02571026 0,07650445 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02571026 0,07641138 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02571026 0,07631854 ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02571026 0,07622592 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02571026 0,07613352 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02571026 0,07604135 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02571026 0,0759494 ! spinal cord patterning GO:0021511 14 7 0,000 0,02571026 0,07585768 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02571026 0,07576617 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02571026 0,07567489 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02571026 0,07558382 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02571026 0,07549298 ! adrenal gland development GO:0030325 17 7 0,000 0,02571026 0,07540235 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02571026 0,07531194 ! ovulation GO:0030728 10 7 0,000 0,02571026 0,07522174 ! adenohypophysis development GO:0021984 11 7 0,000 0,02571026 0,07513177 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02571026 0,075042 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02571026 0,07495245 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02571026 0,07486312 ! microtubule nucleation GO:0007020 21 7 0,000 0,02571026 0,074774 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02571026 0,07468509 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02571026 0,07459639 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02571026 0,0745079 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02571026 0,07441962 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02571026 0,07433155 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02571026 0,07424368 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02571026 0,07415603 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02571026 0,07406858 ! galactose metabolic process GO:0006012 13 7 0,000 0,02571026 0,07398134 ! vesicle fusion GO:0006906 20 7 0,000 0,02571026 0,0738943 ! response to dietary excess GO:0002021 8 7 0,000 0,02571026 0,07380747 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02571026 0,07372084 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02571026 0,07363442 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02571026 0,07354819 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02571026 0,07346217 ! organ growth GO:0035265 15 7 0,000 0,02571026 0,07337635 ! nucleoside transport GO:0015858 11 7 0,000 0,02571026 0,07329073 ! nucleoside salvage GO:0043174 11 7 0,000 0,02571026 0,07320531 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02571026 0,07312009 ! male sex determination GO:0030238 15 7 0,000 0,02571026 0,07303507 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02571026 0,07295024 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02571026 0,07286561 ! parturition GO:0007567 16 7 0,000 0,02571026 0,07278118 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02571026 0,07269694 ! rRNA modification GO:0000154 14 7 0,000 0,02571026 0,0726129 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02571026 0,07252905 ! spindle checkpoint GO:0031577 16 7 0,000 0,02571026 0,07244539 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02571026 0,07236193 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02571026 0,07227866 ! monocyte differentiation GO:0030224 16 7 0,000 0,02571026 0,07219558 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02571026 0,07211269 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02571026 0,07203 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02571026 0,07194749 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02571026 0,07186517 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02571026 0,07178304 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02571026 0,07170109 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02571026 0,07161934 ! eating behavior GO:0042755 8 7 0,000 0,02571026 0,07153776 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02571026 0,07145638 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02571026 0,07137518 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02571026 0,07129416 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02571026 0,07121333 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,02571026 0,07113268 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02571026 0,07105221 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02571026 0,07097193 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02571026 0,07089182 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02571026 0,0708119 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02571026 0,07073216 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02571026 0,07065259 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02571026 0,07057321 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,02571026 0,070494 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02571026 0,07041497 ! histone ubiquitination GO:0016574 9 7 0,000 0,02571026 0,07033612 ! regulation of meiosis GO:0040020 12 7 0,000 0,02571026 0,07025745 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02571026 0,07017895 ! regulation of lipid transport GO:0032368 14 7 0,000 0,02571026 0,07010062 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02571026 0,07002247 ! transcription termination GO:0006353 14 7 0,000 0,02571026 0,0699445 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02571026 0,06986669 ! anaphase GO:0051322 18 7 0,000 0,02571026 0,06978906 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02571026 0,06971161 ! axonal fasciculation GO:0007413 19 7 0,000 0,02571026 0,06963432 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02571026 0,06955721 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02571026 0,06948026 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02571026 0,06940349 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02571026 0,06932688 ! diuresis GO:0030146 12 7 0,000 0,02571026 0,06925045 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02571026 0,06917418 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02571026 0,06909808 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02571026 0,06902215 ! antibiotic transport GO:0042891 9 7 0,000 0,02571026 0,06894639 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02571026 0,06887079 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02571026 0,06879535 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02571026 0,06872008 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02571026 0,06864498 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02571026 0,06857004 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02571026 0,06849526 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02571026 0,06842065 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02571026 0,0683462 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02571026 0,06827191 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02571026 0,06819778 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02571026 0,06812381 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02571026 0,06805001 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02571026 0,06797636 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02571026 0,06790287 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02571026 0,06782954 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02571026 0,06775637 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02571026 0,06768336 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02571026 0,0676105 ! muscle adaptation GO:0043500 13 7 0,000 0,02571026 0,0675378 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02571026 0,06746526 ! retina homeostasis GO:0001895 12 7 0,000 0,02571026 0,06739287 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02571026 0,06732064 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02571026 0,06724856 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02571026 0,06717664 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02571026 0,06710487 ! activation of MAPK activity GO:0000187 124 67 1,000 0,02586015 0,06742407 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,02586015 0,06735219 GO:0035113|embryonic appendage morphogenesis, ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,02658005 0,06915342 ! viral reproduction GO:0016032 142 68 1,000 0,02658005 0,06907985 ! regulation of lipase activity GO:0060191 137 68 1,000 0,02658005 0,06900644 ! adaptive immune response GO:0002250 126 68 1,000 0,02658005 0,06893319 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 0,02658005 0,06886009 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 0,02730801 0,07067106 ! developmental maturation GO:0021700 128 69 1,000 0,02730801 0,07059628 ! germ cell development GO:0007281 133 70 1,000 0,02804398 0,07242224 ! activation of immune response GO:0002253 120 70 1,000 0,02804398 0,07234576 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,0293292 0,07558146 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,0293292 0,07550182 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,0293292 0,07542234 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,0293292 0,07534303 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,0293292 0,07526389 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,0293292 0,07518492 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,0293292 0,07510611 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,0293292 0,07502746 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,0293292 0,07494898 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,0293292 0,07487066 ! meiotic prophase I GO:0007128 14 8 0,000 0,0293292 0,07479251 ! response to zinc ion GO:0010043 12 8 0,000 0,0293292 0,07471452 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,0293292 0,07463669 ! oligopeptide transport GO:0006857 16 8 0,000 0,0293292 0,07455903 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,0293292 0,07448152 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,0293292 0,07440418 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,0293292 0,074327 ! signal peptide processing GO:0006465 12 8 0,000 0,0293292 0,07424997 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,0293292 0,07417311 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,0293292 0,07409641 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,0293292 0,07401986 ! succinate metabolic process GO:0006105 17 8 0,000 0,0293292 0,07394347 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,0293292 0,07386724 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,0293292 0,07379117 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,0293292 0,07371525 ! estrogen metabolic process GO:0008210 17 8 0,000 0,0293292 0,07363949 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,0293292 0,07356389 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,0293292 0,07348844 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,0293292 0,07341314 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0293292 0,073338 ! reflex GO:0060004 17 8 0,000 0,0293292 0,07326301 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,0293292 0,07318818 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,0293292 0,0731135 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,0293292 0,07303897 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,0293292 0,07296459 ! pigment granule organization GO:0048753 17 8 0,000 0,0293292 0,07289036 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,0293292 0,07281629 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,0293292 0,07274236 ! astrocyte differentiation GO:0048708 19 8 0,000 0,0293292 0,07266859 ! histidine catabolic process GO:0006548 10 8 0,000 0,0293292 0,07259496 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,0293292 0,07252148 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,0293292 0,07244816 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,0293292 0,07237498 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,0293292 0,07230194 ! melanin metabolic process GO:0006582 17 8 0,000 0,0293292 0,07222906 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,0293292 0,07215632 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,0293292 0,07208373 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,0293292 0,07201128 ! macrophage activation GO:0042116 13 8 0,000 0,0293292 0,07193898 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,0293292 0,07186683 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,0293292 0,07179482 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,0293292 0,07172295 ! purine salvage GO:0043101 12 8 0,000 0,0293292 0,07165123 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,0293292 0,07157965 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,0293292 0,07150821 ! osteoblast development GO:0002076 17 8 0,000 0,0293292 0,07143691 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,0293292 0,07136576 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,0293292 0,07129475 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,0293292 0,07122388 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,0293292 0,07115315 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,0293292 0,07108257 ! response to UV-B GO:0010224 17 8 0,000 0,0293292 0,07101212 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,0293292 0,07094181 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,0293292 0,07087164 ! intermediate filament organization GO:0045109 12 8 0,000 0,0293292 0,07080161 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,0293292 0,07073171 ! cellular extravasation GO:0045123 13 8 0,000 0,0293292 0,07066196 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,0293292 0,07059234 ! response to antibiotic GO:0046677 11 8 0,000 0,0293292 0,07052286 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,0293292 0,07045352 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,0293292 0,07038431 ! DNA topological change GO:0006265 12 8 0,000 0,0293292 0,07031524 ! response to tropane GO:0014073 15 8 0,000 0,0293292 0,0702463 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,0293292 0,0701775 ! melanosome transport GO:0032402 13 8 0,000 0,0293292 0,07010883 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,0293292 0,0700403 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,0293292 0,0699719 ! mast cell activation GO:0045576 14 8 0,000 0,0293292 0,06990363 ! multicellular organismal aging GO:0010259 20 8 0,000 0,0293292 0,0698355 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,0293292 0,0697675 ! gas homeostasis GO:0033483 14 8 0,000 0,0293292 0,06969964 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,0293292 0,0696319 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,0293292 0,0695643 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,0293292 0,06949682 ! nucleosome disassembly GO:0006337 14 8 0,000 0,0293292 0,06942948 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,0293292 0,06936227 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,0293292 0,06929519 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,0293292 0,06922824 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,0293292 0,06916141 ! intracellular lipid transport GO:0032365 16 8 0,000 0,0293292 0,06909472 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,0293292 0,06902816 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,0293292 0,06896172 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,0293292 0,06889541 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,0293292 0,06882923 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,0293292 0,06876317 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,0293292 0,06869724 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,0293292 0,06863144 ! hormone catabolic process GO:0042447 17 8 0,000 0,0293292 0,06856577 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,0293292 0,06850022 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,0293292 0,06843479 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,0293292 0,06836949 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,0293292 0,06830431 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,0293292 0,06823926 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,0293292 0,06817433 ! adult feeding behavior GO:0008343 10 8 0,000 0,0293292 0,06810953 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,0293292 0,06804485 ! ATP catabolic process GO:0006200 11 8 0,000 0,0293292 0,06798029 ! blastocyst growth GO:0001832 19 8 0,000 0,0293292 0,06791585 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,0293292 0,06785154 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,0293292 0,06778735 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,0293292 0,06772328 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,0293292 0,06765933 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,0293292 0,0675955 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,0293292 0,06753179 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,0293292 0,0674682 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,0293292 0,06740473 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,0293292 0,06734138 GO:0006043|glucosamine catabolic process, ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,0293292 0,06727815 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,0293292 0,06721503 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,0293292 0,06715204 ! protein prenylation GO:0018342 21 8 0,000 0,0293292 0,06708916 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,0293292 0,0670264 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,0293292 0,06696376 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,0293292 0,06690124 ! appendage morphogenesis GO:0035107 150 72 1,000 0,02953963 0,06731838 GO:0035108|limb morphogenesis, ! B cell activation GO:0042113 179 72 1,000 0,02953963 0,06725564 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 0,02953963 0,06719302 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 1,000 0,02953963 0,06713052 ! regulation of MAPKKK cascade GO:0043408 157 72 1,000 0,02953963 0,06706813 ! appendage development GO:0048736 151 73 1,000 0,03029917 0,06872877 GO:0060173|limb development, ! regulation of immune effector process GO:0002697 156 73 1,000 0,03029917 0,06866501 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,03184139 0,07209315 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 1,000 0,03184139 0,0720264 ! eye development GO:0001654 155 75 1,000 0,03184139 0,07195977 ! rhythmic process GO:0048511 142 75 1,000 0,03184139 0,07189326 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 1,000 0,03262392 0,07359208 ! axon extension GO:0048675 16 9 0,000 0,03293479 0,07422482 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,03293479 0,07415641 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03293479 0,07408812 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03293479 0,07401997 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03293479 0,07395193 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03293479 0,07388402 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03293479 0,07381624 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03293479 0,07374858 ! reproductive behavior GO:0019098 22 9 0,000 0,03293479 0,07368105 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03293479 0,07361363 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,03293479 0,07354635 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,03293479 0,07347918 ! UTP metabolic process GO:0046051 10 9 0,000 0,03293479 0,07341214 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,03293479 0,07334522 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03293479 0,07327842 ! artery development GO:0060840 25 9 0,000 0,03293479 0,07321174 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03293479 0,07314518 ! regulation of glycolysis GO:0006110 20 9 0,000 0,03293479 0,07307875 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03293479 0,07301243 ! equilibrioception GO:0050957 20 9 0,000 0,03293479 0,07294624 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,03293479 0,07288017 ! chemosensory behavior GO:0007635 21 9 0,000 0,03293479 0,07281421 ! microtubule bundle formation GO:0001578 22 9 0,000 0,03293479 0,07274837 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,03293479 0,07268266 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,03293479 0,07261706 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03293479 0,07255158 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03293479 0,07248622 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03293479 0,07242097 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03293479 0,07235585 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03293479 0,07229084 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03293479 0,07222594 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03293479 0,07216117 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03293479 0,07209651 ! protein targeting to ER GO:0045047 25 9 0,000 0,03293479 0,07203196 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03293479 0,07196753 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,03293479 0,07190322 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03293479 0,07183902 ! glycine catabolic process GO:0006546 15 9 0,000 0,03293479 0,07177494 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03293479 0,07171096 ! endosome organization GO:0007032 20 9 0,000 0,03293479 0,07164711 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03293479 0,07158337 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03293479 0,07151974 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03293479 0,07145622 ! mannose metabolic process GO:0006013 13 9 0,000 0,03293479 0,07139282 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03293479 0,07132952 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03293479 0,07126634 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,03293479 0,07120328 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03293479 0,07114032 ! receptor clustering GO:0043113 20 9 0,000 0,03293479 0,07107748 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03293479 0,07101474 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03293479 0,07095212 ! retinol metabolic process GO:0042572 20 9 0,000 0,03293479 0,07088961 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03293479 0,0708272 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03293479 0,07076491 GO:0007351|tripartite regional subdivision, ! oligodendrocyte development GO:0014003 11 9 0,000 0,03293479 0,07070273 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,03293479 0,07064065 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03293479 0,07057869 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03293479 0,07051683 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03293479 0,07045508 ! response to amine stimulus GO:0014075 13 9 0,000 0,03293479 0,07039344 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03293479 0,07033191 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03293479 0,07027048 ! erythrocyte development GO:0048821 17 9 0,000 0,03293479 0,07020916 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03293479 0,07014795 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,03293479 0,07008685 ! renal water homeostasis GO:0003091 15 9 0,000 0,03293479 0,07002585 ! postreplication repair GO:0006301 25 9 0,000 0,03293479 0,06996496 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03293479 0,06990417 ! icosanoid secretion GO:0032309 15 9 0,000 0,03293479 0,06984349 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03293479 0,06978292 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03293479 0,06972245 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03293479 0,06966208 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03293479 0,06960182 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03293479 0,06954166 ! sterol catabolic process GO:0016127 14 9 0,000 0,03293479 0,06948161 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,03293479 0,06942166 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03293479 0,06936181 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03293479 0,06930207 ! S phase GO:0051320 10 9 0,000 0,03293479 0,06924243 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03293479 0,06918289 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,03293479 0,06912346 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03293479 0,06906412 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03293479 0,06900489 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03293479 0,06894576 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03293479 0,06888673 ! purine base metabolic process GO:0006144 25 9 0,000 0,03293479 0,0688278 ! pigment granule transport GO:0051904 17 9 0,000 0,03293479 0,06876898 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,03293479 0,06871025 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03293479 0,06865162 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03293479 0,0685931 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03293479 0,06853467 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03293479 0,06847634 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03293479 0,06841811 ! mitochondrion localization GO:0051646 18 9 0,000 0,03293479 0,06835999 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,03341397 0,0692957 ! cytosolic calcium ion homeostasis GO:0051480 149 77 1,000 0,03341397 0,06923693 ! positive regulation of ligase activity GO:0051351 130 77 1,000 0,03341397 0,06917825 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,03501641 0,07243444 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,03582865 0,07405194 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,0365271 0,07543171 ! regulation of developmental growth GO:0048638 16 10 0,000 0,0365271 0,075368 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,0365271 0,07530439 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,0365271 0,0752409 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,0365271 0,07517751 ! associative learning GO:0008306 21 10 0,000 0,0365271 0,07511423 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,0365271 0,07505106 ! phosphate transport GO:0006817 24 10 0,000 0,0365271 0,07498799 ! cell volume homeostasis GO:0006884 17 10 0,000 0,0365271 0,07492503 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,0365271 0,07486217 ! CTP metabolic process GO:0046036 11 10 0,000 0,0365271 0,07479942 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,0365271 0,07473677 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,0365271 0,07467423 ! GTP metabolic process GO:0046039 11 10 0,000 0,0365271 0,0746118 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,0365271 0,07454946 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,0365271 0,07448723 ! social behavior GO:0035176 29 10 0,000 0,0365271 0,07442511 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,0365271 0,07436309 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,0365271 0,07430117 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,0365271 0,07423936 ! androgen metabolic process GO:0008209 17 10 0,000 0,0365271 0,07417765 ! phospholipid efflux GO:0033700 19 10 0,000 0,0365271 0,07411604 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,0365271 0,07405453 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,0365271 0,07399312 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,0365271 0,07393182 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,0365271 0,07387062 ! pathogenesis GO:0009405 17 10 0,000 0,0365271 0,07380952 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0365271 0,07374852 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,0365271 0,07368762 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,0365271 0,07362682 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,0365271 0,07356612 ! endoderm development GO:0007492 18 10 0,000 0,0365271 0,07350552 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,0365271 0,07344503 ! arginine catabolic process GO:0006527 17 10 0,000 0,0365271 0,07338463 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,0365271 0,07332433 ! proline metabolic process GO:0006560 13 10 0,000 0,0365271 0,07326413 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,0365271 0,07320403 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,0365271 0,07314402 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,0365271 0,07308412 ! V(D)J recombination GO:0033151 34 10 0,000 0,0365271 0,07302431 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,0365271 0,0729646 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,0365271 0,07290499 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,0365271 0,07284548 ! B cell proliferation GO:0042100 19 10 0,000 0,0365271 0,07278606 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,0365271 0,07272674 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,0365271 0,07266751 ! multicellular organism growth GO:0035264 19 10 0,000 0,0365271 0,07260839 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,0365271 0,07254936 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,0365271 0,07249042 ! ruffle organization GO:0031529 17 10 0,000 0,0365271 0,07243158 ! epithelial cell development GO:0002064 21 10 0,000 0,0365271 0,07237284 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,0365271 0,07231419 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,0365271 0,07225563 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,0365271 0,07219717 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,0365271 0,07213881 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,0365271 0,07208054 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,0365271 0,07202236 GO:0030204|chondroitin sulfate metabolic process, ! motor axon guidance GO:0008045 22 10 0,000 0,0365271 0,07196428 ! copper ion homeostasis GO:0055070 13 10 0,000 0,0365271 0,07190629 ! protein heterooligomerization GO:0051291 17 10 0,000 0,0365271 0,0718484 ! brain morphogenesis GO:0048854 23 10 0,000 0,0365271 0,07179059 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,0365271 0,07173288 ! segment specification GO:0007379 15 10 0,000 0,0365271 0,07167527 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,0365271 0,07161774 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,0365271 0,07156031 ! blastoderm segmentation GO:0007350 19 10 0,000 0,0365271 0,07150297 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,0365271 0,07144572 ! response to dsRNA GO:0043331 23 10 0,000 0,0365271 0,07138857 ! DNA ligation GO:0006266 18 10 0,000 0,0365271 0,0713315 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,0365271 0,07127453 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,0365271 0,07121764 ! melanosome localization GO:0032400 16 10 0,000 0,0365271 0,07116085 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,0365271 0,07110415 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,0365271 0,07104754 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,0365271 0,07099102 ! induction of an organ GO:0001759 17 10 0,000 0,0365271 0,07093458 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,0365271 0,07087824 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,0365271 0,07082199 ! protein sumoylation GO:0016925 17 10 0,000 0,0365271 0,07076583 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,0365271 0,07070975 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,0365271 0,07065377 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0365271 0,07059787 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,0365271 0,07054206 ! salivary gland development GO:0007431 28 10 0,000 0,0365271 0,07048634 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,0365271 0,07043071 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,0365271 0,07037516 ! midbrain development GO:0030901 14 10 0,000 0,0365271 0,07031971 ! musculoskeletal movement GO:0050881 16 10 0,000 0,0365271 0,07026434 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,0365271 0,07020905 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,0365271 0,07015386 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,0365271 0,07009875 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,0365271 0,07004373 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,0365271 0,06998879 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,0365271 0,06993394 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,0365271 0,06987918 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,0365271 0,0698245 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,0365271 0,0697699 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,0365271 0,0697154 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,0365271 0,06966097 ! blastocyst formation GO:0001825 18 10 0,000 0,0365271 0,06960664 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,0365271 0,06955238 ! cerebellar cortex development GO:0021695 16 10 0,000 0,0365271 0,06949821 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,0365271 0,06944413 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,0365271 0,06939013 ! response to nicotine GO:0035094 20 10 0,000 0,0365271 0,06933621 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,03664816 0,069512 ! protein import into nucleus GO:0006606 174 82 1,000 0,03747488 0,07102492 ! response to drug GO:0042493 149 83 1,000 0,03830873 0,07254901 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,03830873 0,07249282 GO:0045937|positive regulation of phosphate metabolic process, ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,03830873 0,07243671 ! nuclear import GO:0051170 177 83 1,000 0,03830873 0,07238068 ! regulation of ligase activity GO:0051340 147 84 1,000 0,03914966 0,07391237 ! negative regulation of transport GO:0051051 164 85 1,000 0,03999759 0,07545492 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,04010616 0,07560136 ! respiratory burst GO:0045730 17 11 0,000 0,04010616 0,07554307 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,04010616 0,07548487 ! telencephalon cell migration GO:0022029 23 11 0,000 0,04010616 0,07542676 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,04010616 0,07536874 ! thyroid gland development GO:0030878 26 11 0,000 0,04010616 0,07531081 ! synapsis GO:0007129 14 11 0,000 0,04010616 0,07525296 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,04010616 0,07519521 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,04010616 0,07513754 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,04010616 0,07507997 ! response to pain GO:0048265 27 11 0,000 0,04010616 0,07502248 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,04010616 0,07496508 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,04010616 0,07490777 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,04010616 0,07485054 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 16 11 0,000 0,04010616 0,0747934 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,04010616 0,07473635 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,04010616 0,07467939 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,04010616 0,07462251 ! melanocyte differentiation GO:0030318 20 11 0,000 0,04010616 0,07456572 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,04010616 0,07450902 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,04010616 0,0744524 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,04010616 0,07439587 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,04010616 0,07433942 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,04010616 0,07428306 ! UV protection GO:0009650 20 11 0,000 0,04010616 0,07422679 ! adult heart development GO:0007512 16 11 0,000 0,04010616 0,0741706 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,04010616 0,07411449 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,04010616 0,07405847 ! macroautophagy GO:0016236 19 11 0,000 0,04010616 0,07400254 ! temperature homeostasis GO:0001659 18 11 0,000 0,04010616 0,07394669 ! behavioral fear response GO:0001662 27 11 0,000 0,04010616 0,07389092 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,04010616 0,07383524 ! negative regulation of ossification GO:0030279 27 11 0,000 0,04010616 0,07377964 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,04010616 0,07372412 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,04010616 0,07366869 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,04010616 0,07361334 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,04010616 0,07355808 ! regulation of organ growth GO:0046620 14 11 0,000 0,04010616 0,07350289 ! pigment granule localization GO:0051875 20 11 0,000 0,04010616 0,07344779 ! vasoconstriction GO:0042310 20 11 0,000 0,04010616 0,07339278 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,04010616 0,07333784 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,04010616 0,07328299 ! embryonic axis specification GO:0000578 19 11 0,000 0,04010616 0,07322822 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,04010616 0,07317353 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,04010616 0,07311892 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,04010616 0,0730644 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,04010616 0,07300995 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,04010616 0,07295559 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,04010616 0,07290131 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,04010616 0,07284711 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,04010616 0,07279299 ! prophase GO:0051324 17 11 0,000 0,04010616 0,07273894 ! nucleosome positioning GO:0016584 15 11 0,000 0,04010616 0,07268498 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,04010616 0,0726311 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,04010616 0,0725773 ! apical protein localization GO:0045176 18 11 0,000 0,04010616 0,07252358 ! acid secretion GO:0046717 20 11 0,000 0,04010616 0,07246994 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,04010616 0,07241638 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,04010616 0,07236289 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,04010616 0,07230949 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,04010616 0,07225616 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,04010616 0,07220292 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,04010616 0,07214975 ! cholesterol efflux GO:0033344 21 11 0,000 0,04010616 0,07209666 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,04010616 0,07204365 ! oocyte development GO:0048599 20 11 0,000 0,04010616 0,07199071 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,04010616 0,07193785 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,04010616 0,07188508 ! embryonic gut development GO:0048566 19 11 0,000 0,04010616 0,07183237 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,04010616 0,07177975 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,04010616 0,0717272 ! activation of innate immune response GO:0002218 16 11 0,000 0,04010616 0,07167473 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,04010616 0,07162234 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,04010616 0,07157002 ! lysogeny GO:0030069 22 11 0,000 0,04010616 0,07151778 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,04010616 0,07146561 ! sequestering of metal ion GO:0051238 15 11 0,000 0,04010616 0,07141353 ! regulation of embryonic development GO:0045995 35 11 0,000 0,04010616 0,07136151 ! regulation of protein transport GO:0051223 165 87 1,000 0,04171426 0,0741688 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 167 89 1,000 0,04345821 0,0772134 ! protein localization in nucleus GO:0034504 192 89 1,000 0,04345821 0,07715728 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,04367203 0,07748059 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,04367203 0,07742436 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,04367203 0,07736822 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,04367203 0,07731215 ! virus-host interaction GO:0019048 30 12 0,000 0,04367203 0,07725617 ! mating GO:0007618 17 12 0,000 0,04367203 0,07720027 ! protein complex disassembly GO:0043241 28 12 0,000 0,04367203 0,07714445 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,04367203 0,07708871 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,04367203 0,07703305 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,04367203 0,07697747 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,04367203 0,07692197 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,04367203 0,07686655 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,04367203 0,07681121 ! drug transport GO:0015893 16 12 0,000 0,04367203 0,07675595 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,04367203 0,07670077 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,04367203 0,07664567 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,04367203 0,07659065 ! polyamine metabolic process GO:0006595 18 12 0,000 0,04367203 0,07653571 ! focal adhesion formation GO:0048041 37 12 0,000 0,04367203 0,07648084 ! mitotic spindle organization GO:0007052 23 12 0,000 0,04367203 0,07642606 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,04367203 0,07637135 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,04367203 0,07631672 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,04367203 0,07626217 ! lipid digestion GO:0044241 21 12 0,000 0,04367203 0,0762077 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,04367203 0,0761533 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04367203 0,07609898 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,04367203 0,07604474 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,04367203 0,07599058 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,04367203 0,07593649 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,04367203 0,07588248 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,04367203 0,07582855 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,04367203 0,0757747 ! snRNA metabolic process GO:0016073 30 12 0,000 0,04367203 0,07572092 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,04367203 0,07566722 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,04367203 0,07561359 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,04367203 0,07556004 ! cranial nerve development GO:0021545 23 12 0,000 0,04367203 0,07550656 ! fucose catabolic process GO:0019317 25 12 0,000 0,04367203 0,07545316 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,04367203 0,07539984 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,04367203 0,07534659 ! autonomic nervous system development GO:0048483 24 12 0,000 0,04367203 0,07529342 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,04367203 0,07524032 ! zymogen activation GO:0031638 18 12 0,000 0,04367203 0,0751873 ! T cell homeostasis GO:0043029 28 12 0,000 0,04367203 0,07513435 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,04367203 0,07508147 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,04367203 0,07502867 ! oocyte differentiation GO:0009994 21 12 0,000 0,04367203 0,07497595 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,04367203 0,0749233 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,04367203 0,07487072 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,04367203 0,07481821 GO:0042130|negative regulation of T cell proliferation, ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,04367203 0,07476578 ! defense response to fungus GO:0050832 15 12 0,000 0,04367203 0,07471343 ! developmental induction GO:0031128 22 12 0,000 0,04367203 0,07466114 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,04367203 0,07460893 ! lamellipodium assembly GO:0030032 24 12 0,000 0,04367203 0,07455679 ! response to cold GO:0009409 17 12 0,000 0,04367203 0,07450473 ! establishment of cell polarity GO:0030010 21 12 0,000 0,04367203 0,07445274 ! regulation of synapse organization GO:0050807 18 12 0,000 0,04367203 0,07440082 ! response to unfolded protein GO:0006986 139 90 1,000 0,04434028 0,07548662 ! gland development GO:0048732 220 91 1,000 0,04522898 0,07694596 ! regulation of cell morphogenesis GO:0022604 243 93 1,000 0,04702606 0,07994758 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,04722475 0,08022954 ! cGMP metabolic process GO:0046068 18 13 0,000 0,04722475 0,08017378 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,04722475 0,08011811 ! regulation of chemokine production GO:0032642 18 13 0,000 0,04722475 0,08006251 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,04722475 0,08000698 ! peroxisomal transport GO:0043574 28 13 0,000 0,04722475 0,07995154 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,04722475 0,07989617 ! cartilage condensation GO:0001502 22 13 0,000 0,04722475 0,07984088 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,04722475 0,07978566 ! organelle fusion GO:0048284 36 13 0,000 0,04722475 0,07973053 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,04722475 0,07967546 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,04722475 0,07962048 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,04722475 0,07956557 ! endocrine pancreas development GO:0031018 25 13 0,000 0,04722475 0,07951073 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,04722475 0,07945597 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,04722475 0,07940129 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,04722475 0,07934668 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,04722475 0,07929215 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,04722475 0,07923769 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,04722475 0,0791833 ! methionine metabolic process GO:0006555 31 13 0,000 0,04722475 0,07912899 ! plasma membrane organization GO:0007009 27 13 0,000 0,04722475 0,07907476 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,04722475 0,0790206 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,04722475 0,07896651 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,04722475 0,0789125 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,04722475 0,07885856 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,04722475 0,07880469 ! exocrine system development GO:0035272 34 13 0,000 0,04722475 0,0787509 ! asymmetric protein localization GO:0008105 24 13 0,000 0,04722475 0,07869718 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,04722475 0,07864354 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,04722475 0,07858997 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,04722475 0,07853647 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,04722475 0,07848304 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,04722475 0,07842969 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,04722475 0,07837641 ! protein homotetramerization GO:0051289 24 13 0,000 0,04722475 0,0783232 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,04722475 0,07827006 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,04722475 0,078217 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,04722475 0,078164 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,04722475 0,07811108 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,04722475 0,07805824 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,04722475 0,07800546 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,04722475 0,07795275 ! histone methylation GO:0016571 29 13 0,000 0,04722475 0,07790012 ! chromatin silencing GO:0006342 29 13 0,000 0,04722475 0,07784755 ! gland morphogenesis GO:0022612 31 13 0,000 0,04722475 0,07779506 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,04722475 0,07774264 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,04722475 0,07769028 ! regulation of epidermis development GO:0045682 19 13 0,000 0,04722475 0,077638 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,04722475 0,07758579 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,04722475 0,07753365 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,04722475 0,07748158 ! spleen development GO:0048536 24 13 0,000 0,04722475 0,07742958 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,04722475 0,07737765 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,04722475 0,07732579 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,04722475 0,07727399 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,04722475 0,07722227 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,04722475 0,07717062 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,04722475 0,07711903 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,04722475 0,07706752 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,04722475 0,07701607 ! insulin secretion GO:0030073 24 13 0,000 0,04722475 0,07696469 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,04722475 0,07691338 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,04722475 0,07686214 ! acrosome reaction GO:0007340 19 13 0,000 0,04722475 0,07681097 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,04722475 0,07675986 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,04722475 0,07670882 ! sex differentiation GO:0007548 171 96 1,000 0,04976998 0,08078941 ! response to protein stimulus GO:0051789 158 96 1,000 0,04976998 0,08073577 ! regulation of T cell activation GO:0050863 175 96 1,000 0,04976998 0,08068219 ! regulation of protein localization GO:0032880 188 97 1,000 0,05069726 0,08213091 ! rRNA transcription GO:0009303 28 14 0,000 0,05076438 0,08218514 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,05076438 0,08213071 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,05076438 0,08207635 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,05076438 0,08202207 ! non-recombinational repair GO:0000726 29 14 0,000 0,05076438 0,08196786 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,05076438 0,08191372 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,05076438 0,08185965 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,05076438 0,08180565 ! RNA polyadenylation GO:0043631 32 14 0,000 0,05076438 0,08175173 ! lipid localization GO:0010876 32 14 0,000 0,05076438 0,08169787 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,05076438 0,08164409 ! regulated secretory pathway GO:0045055 24 14 0,000 0,05076438 0,08159037 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,05076438 0,08153673 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,05076438 0,08148316 ! arginine metabolic process GO:0006525 21 14 0,000 0,05076438 0,08142966 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,05076438 0,08137623 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,05076438 0,08132287 ! regulation of heart rate GO:0002027 25 14 0,000 0,05076438 0,08126957 ! fear response GO:0042596 34 14 0,000 0,05076438 0,08121635 ! organic alcohol transport GO:0015850 29 14 0,000 0,05076438 0,0811632 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,05076438 0,08111012 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,05076438 0,0810571 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,05076438 0,08100416 ! neutral amino acid transport GO:0015804 28 14 0,000 0,05076438 0,08095129 ! bone mineralization GO:0030282 18 14 0,000 0,05076438 0,08089848 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,05076438 0,08084574 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,05076438 0,08079307 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,05076438 0,08074047 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,05076438 0,08068794 ! ribosome assembly GO:0042255 18 14 0,000 0,05076438 0,08063548 ! cerebellum development GO:0021549 23 14 0,000 0,05076438 0,08058309 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,05076438 0,08053076 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,05076438 0,0804785 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,05076438 0,08042631 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,05076438 0,08037419 ! NADP metabolic process GO:0006739 24 14 0,000 0,05076438 0,08032213 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,05076438 0,08027014 ! oxygen transport GO:0015671 22 14 0,000 0,05076438 0,08021822 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,05076438 0,08016637 ! male genitalia development GO:0030539 26 14 0,000 0,05076438 0,08011458 ! regulation of axon extension GO:0030516 43 14 0,000 0,05076438 0,08006286 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,05076438 0,08001121 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,05076438 0,07995962 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,05351621 0,08423976 GO:0060538|skeletal muscle organ development, ! positive regulation of immune response GO:0050778 175 100 1,000 0,05351621 0,08418552 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,05429095 0,08534928 ! lactation GO:0007595 30 15 0,000 0,05429095 0,0852944 ! reproductive cellular process GO:0048610 22 15 0,000 0,05429095 0,08523958 ! tRNA modification GO:0006400 24 15 0,000 0,05429095 0,08518483 ! superoxide anion generation GO:0042554 22 15 0,000 0,05429095 0,08513016 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,05429095 0,08507555 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,05429095 0,08502102 ! copper ion transport GO:0006825 22 15 0,000 0,05429095 0,08496655 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,05429095 0,08491215 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,05429095 0,08485783 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,05429095 0,08480357 ! sulfate transport GO:0008272 27 15 0,000 0,05429095 0,08474938 ! response to cAMP GO:0051591 25 15 0,000 0,05429095 0,08469526 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,05429095 0,08464122 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,05429095 0,08458724 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,05429095 0,08453332 ! response to hexose stimulus GO:0009746 25 15 0,000 0,05429095 0,08447948 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,05429095 0,08442571 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,05429095 0,084372 ! vesicle coating GO:0006901 38 15 0,000 0,05429095 0,08431836 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,05429095 0,08426479 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,05429095 0,08421129 ! regulation of exocytosis GO:0017157 26 15 0,000 0,05429095 0,08415786 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,05429095 0,08410449 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,05429095 0,08405119 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,05429095 0,08399796 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,05429095 0,0839448 ! regulation of vasodilation GO:0042312 27 15 0,000 0,05429095 0,0838917 ! histone deacetylation GO:0016575 24 15 0,000 0,05429095 0,08383868 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,05429095 0,08378571 ! water homeostasis GO:0030104 28 15 0,000 0,05429095 0,08373282 ! cofactor transport GO:0051181 30 15 0,000 0,05429095 0,08367999 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,05429095 0,08362723 ! muscle maintenance GO:0046716 26 15 0,000 0,05429095 0,08357453 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,05429095 0,0835219 ! intestinal absorption GO:0050892 31 15 0,000 0,05429095 0,08346934 ! dopamine metabolic process GO:0042417 35 15 0,000 0,05429095 0,08341685 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,05429095 0,08336442 ! heme biosynthetic process GO:0006783 33 15 0,000 0,05429095 0,08331205 ! cell killing GO:0001906 32 15 0,000 0,05429095 0,08325975 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,05429095 0,08320752 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,05429095 0,08315535 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,05429095 0,08310325 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,05429095 0,08305121 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,05429095 0,08299924 ! actin filament polymerization GO:0030041 27 15 0,000 0,05429095 0,08294733 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,05429095 0,08289549 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,05780452 0,08820514 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,05780452 0,08815008 ! positive regulation of cell size GO:0045793 29 16 0,000 0,05780452 0,08809509 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,05780452 0,08804017 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,05780452 0,08798532 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,05780452 0,08793053 ! bone remodeling GO:0046849 28 16 0,000 0,05780452 0,08787581 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,05780452 0,08782117 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05780452 0,08776658 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,05780452 0,08771207 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,05780452 0,08765763 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,05780452 0,08760325 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,05780452 0,08754894 ! startle response GO:0001964 28 16 0,000 0,05780452 0,08749469 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,05780452 0,08744052 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,05780452 0,08738641 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,05780452 0,08733236 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,05780452 0,08727839 ! protein polyubiquitination GO:0000209 41 16 0,000 0,05780452 0,08722448 ! glutamate metabolic process GO:0006536 25 16 0,000 0,05780452 0,08717064 ! response to osmotic stress GO:0006970 27 16 0,000 0,05780452 0,08711686 ! lysosomal transport GO:0007041 31 16 0,000 0,05780452 0,08706315 ! fructose metabolic process GO:0006000 25 16 0,000 0,05780452 0,08700951 ! L-amino acid transport GO:0015807 33 16 0,000 0,05780452 0,08695593 ! stem cell development GO:0048864 46 16 0,000 0,05780452 0,08690242 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,05780452 0,08684898 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,05780452 0,0867956 ! intermediate filament-based process GO:0045103 36 16 0,000 0,05780452 0,08674228 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,05780452 0,08668903 ! axon cargo transport GO:0008088 46 16 0,000 0,05780452 0,08663585 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,05780452 0,08658273 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,05780452 0,08652968 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,05780452 0,08647669 ! neuron recognition GO:0008038 40 16 0,000 0,05780452 0,08642377 ! mRNA splice site selection GO:0006376 44 16 0,000 0,05780452 0,08637091 ! tissue regeneration GO:0042246 27 16 0,000 0,05780452 0,08631811 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,05780452 0,08626538 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,05780452 0,08621272 ! biomineral formation GO:0031214 22 16 0,000 0,05780452 0,08616012 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,05780452 0,08610758 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,05780452 0,08605511 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,05780452 0,0860027 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,05780452 0,08595036 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,05780452 0,08589807 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,05780452 0,08584586 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,05780452 0,0857937 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! peptide hormone processing GO:0016486 27 16 0,000 0,05780452 0,08574161 ! metencephalon development GO:0022037 32 17 0,000 0,06130513 0,0908789 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,06130513 0,09082379 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,06130513 0,09076875 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,06130513 0,09071377 ! signal complex assembly GO:0007172 47 17 0,000 0,06130513 0,09065886 ! endothelial cell migration GO:0043542 31 17 0,000 0,06130513 0,09060401 ! gene silencing by RNA GO:0031047 38 17 0,000 0,06130513 0,09054923 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,06130513 0,09049452 ! glial cell development GO:0021782 28 17 0,000 0,06130513 0,09043988 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,06130513 0,09038529 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,06130513 0,09033078 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,06130513 0,09027633 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,06130513 0,09022195 ! myoblast differentiation GO:0045445 50 17 0,000 0,06130513 0,09016763 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,06130513 0,09011338 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,06130513 0,09005919 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,06130513 0,09000507 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,06130513 0,08995101 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,06130513 0,08989702 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,06130513 0,08984309 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,06130513 0,08978923 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,06130513 0,08973543 ! membrane budding GO:0006900 42 17 0,000 0,06130513 0,0896817 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,06130513 0,08962803 ! regulation of protein binding GO:0043393 33 17 0,000 0,06130513 0,08957442 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,06130513 0,08952088 ! genitalia development GO:0048806 32 17 0,000 0,06130513 0,0894674 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,06130513 0,08941399 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,06130513 0,08936064 ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,06130513 0,08930735 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,06130513 0,08925413 ! steroid catabolic process GO:0006706 34 17 0,000 0,06130513 0,08920097 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,06130513 0,08914788 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,06130513 0,08909484 ! gas transport GO:0015669 26 17 0,000 0,06130513 0,08904187 ! organic cation transport GO:0015695 32 17 0,000 0,06130513 0,08898897 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,06130513 0,08893612 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,06479284 0,09394 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,06479284 0,09388428 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,06479284 0,09382863 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,06479284 0,09377304 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,06479284 0,09371752 ! adult walking behavior GO:0007628 36 18 0,000 0,06479284 0,09366207 ! patterning of blood vessels GO:0001569 43 18 0,000 0,06479284 0,09360668 ! heart looping GO:0001947 34 18 0,000 0,06479284 0,09355136 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,06479284 0,0934961 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,06479284 0,09344091 ! centrosome cycle GO:0007098 26 18 0,000 0,06479284 0,09338578 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,06479284 0,09333072 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,06479284 0,09327572 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,06479284 0,09322079 ! glycine metabolic process GO:0006544 30 18 0,000 0,06479284 0,09316592 ! glutamine metabolic process GO:0006541 29 18 0,000 0,06479284 0,09311112 ! response to retinoic acid GO:0032526 31 18 0,000 0,06479284 0,09305638 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,06479284 0,0930017 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,06479284 0,09294709 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,06479284 0,09289255 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,06479284 0,09283806 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,06479284 0,09278365 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,06479284 0,09272929 ! neural crest cell migration GO:0001755 41 18 0,000 0,06479284 0,092675 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,06479284 0,09262077 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,06479284 0,09256661 GO:0046466|membrane lipid catabolic process, ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,06479284 0,09251251 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,06479284 0,09245847 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,06479284 0,09240449 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,06479284 0,09235058 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,06479284 0,09229673 ! detection of bacterium GO:0016045 22 18 0,000 0,06479284 0,09224295 ! nerve development GO:0021675 34 18 0,000 0,06479284 0,09218922 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,06479284 0,09213556 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,06479284 0,09208197 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,06826768 0,09696392 ! positive regulation of translation GO:0045727 31 19 0,000 0,06826768 0,09690758 ! negative regulation of defense response GO:0031348 27 19 0,000 0,06826768 0,0968513 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,06826768 0,09679509 ! neuron maturation GO:0042551 46 19 0,000 0,06826768 0,09673895 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,06826768 0,09668287 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,06826768 0,09662685 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,06826768 0,0965709 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,06826768 0,09651501 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,06826768 0,09645919 ! inositol metabolic process GO:0006020 33 19 0,000 0,06826768 0,09640344 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,06826768 0,09634774 ! memory GO:0007613 34 19 0,000 0,06826768 0,09629212 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,06826768 0,09623655 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,06826768 0,09618105 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,06826768 0,09612562 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,06826768 0,09607024 ! cerebral cortex development GO:0021987 40 19 0,000 0,06826768 0,09601494 ! pigmentation during development GO:0048066 42 19 0,000 0,06826768 0,09595969 ! response to vitamin A GO:0033189 32 19 0,000 0,06826768 0,09590451 ! heme metabolic process GO:0042168 40 19 0,000 0,06826768 0,09584939 ! neuromuscular junction development GO:0007528 43 19 0,000 0,06826768 0,09579434 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,06826768 0,09573935 ! response to fungus GO:0009620 26 19 0,000 0,06826768 0,09568442 ! peptide cross-linking GO:0018149 39 19 0,000 0,06826768 0,09562956 ! protein export from nucleus GO:0006611 40 19 0,000 0,06826768 0,09557475 ! heart process GO:0003015 32 19 0,000 0,06826768 0,09552001 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,06826768 0,09546534 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,06826768 0,09541072 ! visual learning GO:0008542 38 19 0,000 0,06826768 0,09535617 ! cellular pigmentation GO:0033059 37 19 0,000 0,06826768 0,09530168 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,06826768 0,09524726 ! vitamin transport GO:0051180 31 19 0,000 0,06826768 0,09519289 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,06826768 0,09513859 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,06826768 0,09508435 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,06826768 0,09503017 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,06826768 0,09497605 ! cilium assembly GO:0042384 38 19 0,000 0,06826768 0,09492199 ! peptide hormone secretion GO:0030072 32 19 0,000 0,06826768 0,094868 ! protein secretion GO:0009306 45 20 0,000 0,07172971 0,09962234 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,07172971 0,09956573 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,07172971 0,09950919 ! positive regulation of ossification GO:0045778 50 20 0,000 0,07172971 0,09945272 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,07172971 0,09939631 ! skin development GO:0043588 42 20 0,000 0,07172971 0,09933996 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,07172971 0,09928368 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,07172971 0,09922746 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,07172971 0,0991713 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,07172971 0,09911521 ! response to vitamin GO:0033273 36 20 0,000 0,07172971 0,09905918 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,07172971 0,09900321 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,07172971 0,09894731 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,07172971 0,09889147 ! bile acid metabolic process GO:0008206 34 20 0,000 0,07172971 0,0988357 ! response to alkaloid GO:0043279 38 20 0,000 0,07172971 0,09877998 ! retinoid metabolic process GO:0001523 34 20 0,000 0,07172971 0,09872433 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,07172971 0,09866874 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,07172971 0,09861322 ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,07172971 0,09855775 ! actin filament bundle formation GO:0051017 47 20 0,000 0,07172971 0,09850235 ! body fluid secretion GO:0007589 33 20 0,000 0,07172971 0,09844702 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,07172971 0,09839174 ! peptide secretion GO:0002790 38 20 0,000 0,07172971 0,09833653 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,07172971 0,09828137 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,07172971 0,09822628 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,07172971 0,09817125 ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,07172971 0,09811629 ! cell-cell junction organization GO:0045216 43 20 0,000 0,07172971 0,09806138 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,07172971 0,09800654 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,07172971 0,09795175 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,07172971 0,09789703 ! regulation of glucose import GO:0046324 30 20 0,000 0,07172971 0,09784237 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,07172971 0,09778777 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,07172971 0,09773323 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,07172971 0,09767876 ! negative regulation of translation GO:0017148 32 20 0,000 0,07172971 0,09762434 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,07517898 0,10226183 ! hormone secretion GO:0046879 39 21 0,000 0,07517898 0,10220492 ! cAMP metabolic process GO:0046058 41 21 0,000 0,07517898 0,10214808 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,07517898 0,1020913 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,07517898 0,10203458 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,07517898 0,10197792 ! smooth muscle contraction GO:0006939 48 21 0,000 0,07517898 0,10192133 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,07517898 0,1018648 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,07517898 0,10180834 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,07517898 0,10175193 ! plasma membrane fusion GO:0045026 33 21 0,000 0,07517898 0,10169559 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,07517898 0,10163931 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,07517898 0,1015831 ! sensory perception of pain GO:0019233 33 21 0,000 0,07517898 0,10152694 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,07517898 0,10147085 ! collagen fibril organization GO:0030199 62 21 0,000 0,07517898 0,10141482 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,07517898 0,10135885 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,07517898 0,10130295 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,07517898 0,1012471 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,07517898 0,10119132 ! collagen catabolic process GO:0030574 29 21 0,000 0,07517898 0,1011356 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,07517898 0,10107993 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,07517898 0,10102434 ! sperm-egg recognition GO:0035036 23 21 0,000 0,07517898 0,1009688 ! actin filament-based movement GO:0030048 47 21 0,000 0,07517898 0,10091332 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,07861552 0,10546827 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,07861552 0,10541038 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,07861552 0,10535256 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,07861552 0,1052948 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,07861552 0,10523711 ! microtubule-based transport GO:0010970 59 22 0,000 0,07861552 0,10517947 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,07861552 0,1051219 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,07861552 0,1050644 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,07861552 0,10500695 ! vacuolar transport GO:0007034 41 22 0,000 0,07861552 0,10494957 ! central nervous system neuron development GO:0021954 47 22 0,000 0,07861552 0,10489226 ! fucose metabolic process GO:0006004 44 22 0,000 0,07861552 0,104835 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,07861552 0,10477781 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,07861552 0,10472068 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,07861552 0,10466361 ! ureteric bud development GO:0001657 50 22 0,000 0,07861552 0,1046066 ! stem cell differentiation GO:0048863 57 22 0,000 0,07861552 0,10454966 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,07861552 0,10449277 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,07861552 0,10443595 ! cytolysis GO:0019835 27 22 0,000 0,07861552 0,1043792 ! renal system process GO:0003014 42 22 0,000 0,07861552 0,1043225 ! vasodilation GO:0042311 40 22 0,000 0,07861552 0,10426586 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,07861552 0,10420929 ! G1 phase GO:0051318 44 22 0,000 0,07861552 0,10415278 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,07861552 0,10409633 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,07861552 0,10403993 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,07861552 0,10398361 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,07861552 0,10392734 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,07861552 0,10387113 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,07861552 0,10381498 ! sarcomere organization GO:0045214 32 22 0,000 0,07861552 0,1037589 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,07861552 0,10370287 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,07861552 0,10364691 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,07861552 0,103591 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,07861552 0,10353516 ! gut development GO:0048565 44 22 0,000 0,07861552 0,10347937 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,07861552 0,10342365 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,07861552 0,10336799 ! protein stabilization GO:0050821 41 22 0,000 0,07861552 0,10331238 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,08203939 0,10775389 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,08203939 0,10769599 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,08203939 0,10763815 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,08203939 0,10758037 ! gluconeogenesis GO:0006094 38 23 0,000 0,08203939 0,10752266 ! glycerol metabolic process GO:0006071 40 23 0,000 0,08203939 0,10746501 ! viral genome replication GO:0019079 44 23 0,000 0,08203939 0,10740742 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,08203939 0,10734989 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,08203939 0,10729242 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,08203939 0,10723501 ! regeneration GO:0031099 42 23 0,000 0,08203939 0,10717767 ! axis specification GO:0009798 43 23 0,000 0,08203939 0,10712038 ! visual behavior GO:0007632 46 23 0,000 0,08203939 0,10706316 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,08203939 0,107006 GO:0010810|regulation of cell-substrate adhesion, ! response to ethanol GO:0045471 47 23 0,000 0,08203939 0,1069489 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,08203939 0,10689186 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,08203939 0,10683488 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,08203939 0,10677796 ! peroxisome organization GO:0007031 43 23 0,000 0,08203939 0,10672111 ! lysosome organization GO:0007040 47 23 0,000 0,08203939 0,10666431 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,08203939 0,10660757 ! vesicle targeting GO:0006903 49 23 0,000 0,08203939 0,1065509 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,08203939 0,10649428 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,08203939 0,10643773 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,08203939 0,10638123 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,08203939 0,10632479 ! DNA modification GO:0006304 36 23 0,000 0,08203939 0,10626842 ! fatty acid transport GO:0015908 47 23 0,000 0,08203939 0,1062121 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,08203939 0,10615585 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,08203939 0,10609965 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,08203939 0,10604351 ! hormone transport GO:0009914 41 23 0,000 0,08203939 0,10598743 ! cell-cell recognition GO:0009988 28 23 0,000 0,08203939 0,10593141 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,08203939 0,10587546 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,08203939 0,10581955 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,08203939 0,10576371 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,08545064 0,11010333 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,08545064 0,11004529 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,08545064 0,10998731 ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,08545064 0,10992939 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,08545064 0,10987153 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,08545064 0,10981373 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,08545064 0,109756 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,08545064 0,10969832 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,08545064 0,10964071 ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,08545064 0,10958315 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,08545064 0,10952566 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,08545064 0,10946823 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,08545064 0,10941085 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,08545064 0,10935354 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,08545064 0,10929629 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,08545064 0,10923909 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,08545064 0,10918196 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,08545064 0,10912489 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,08545064 0,10906787 ! membrane depolarization GO:0051899 45 24 0,000 0,08545064 0,10901092 ! oogenesis GO:0048477 44 24 0,000 0,08545064 0,10895402 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,08545064 0,10889719 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,08545064 0,10884041 ! platelet activation GO:0030168 41 24 0,000 0,08545064 0,10878369 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,08545064 0,10872703 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,08545064 0,10867044 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,08545064 0,1086139 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,08545064 0,10855741 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,08545064 0,10850099 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,08545064 0,10844463 ! regulation of amine transport GO:0051952 41 24 0,000 0,08545064 0,10838832 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,08545064 0,10833207 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,0888493 0,11258239 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,0888493 0,11252402 ! phototransduction GO:0007602 37 25 0,000 0,0888493 0,11246572 ! keratinization GO:0031424 37 25 0,000 0,0888493 0,11240748 ! vacuole organization GO:0007033 49 25 0,000 0,0888493 0,1123493 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,0888493 0,11229117 ! receptor metabolic process GO:0043112 53 25 0,000 0,0888493 0,11223311 ! chromosome condensation GO:0030261 48 25 0,000 0,0888493 0,11217511 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,0888493 0,11211717 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,0888493 0,11205929 ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,0888493 0,11200147 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,0888493 0,1119437 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,0888493 0,111886 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,09223543 0,11609024 ! myelination GO:0042552 50 26 0,000 0,09223543 0,11603046 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,09223543 0,11597074 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,09223543 0,11591109 ! molting cycle process GO:0022404 52 26 0,000 0,09223543 0,11585149 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,09223543 0,11579196 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,09223543 0,11573249 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,09223543 0,11567308 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,09223543 0,11561373 GO:0051297|centrosome organization, ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,09223543 0,11555444 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,09223543 0,11549521 ! digestive system process GO:0022600 49 26 0,000 0,09223543 0,11543604 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,09223543 0,11537693 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,09223543 0,11531789 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,09223543 0,1152589 ! osteoblast differentiation GO:0001649 63 26 0,000 0,09223543 0,11519998 ! neural crest cell development GO:0014032 59 26 0,000 0,09223543 0,11514111 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,09223543 0,1150823 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,09223543 0,11502356 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,09223543 0,11496487 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,09223543 0,11490625 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,09223543 0,11484768 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,09223543 0,11478918 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,09223543 0,11473073 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,09223543 0,11467234 ! blastocyst development GO:0001824 50 26 0,000 0,09223543 0,11461401 ! telomere organization GO:0032200 46 26 0,000 0,09223543 0,11455575 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,09223543 0,11449754 ! neural tube closure GO:0001843 58 26 0,000 0,09223543 0,11443939 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,09223543 0,1143813 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,09223543 0,11432326 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,09223543 0,11426529 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,09560907 0,11838467 ! embryonic pattern specification GO:0009880 49 27 0,000 0,09560907 0,1183247 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,09560907 0,11826479 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,09560907 0,11820494 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,09560907 0,11814515 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,09560907 0,11808542 ! iron ion transport GO:0006826 65 27 0,000 0,09560907 0,11802575 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,09560907 0,11796614 ! superoxide metabolic process GO:0006801 41 27 0,000 0,09560907 0,11790659 ! tube lumen formation GO:0035148 59 27 0,000 0,09560907 0,1178471 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,09560907 0,11778767 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,09560907 0,1177283 ! response to toxin GO:0009636 49 27 0,000 0,09560907 0,11766899 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,09560907 0,11760974 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,09560907 0,11755056 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,09560907 0,11749143 ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,09560907 0,11743235 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,09897026 0,12149968 ! vesicle docking GO:0048278 55 28 0,000 0,09897026 0,12143865 ! circadian rhythm GO:0007623 56 28 0,000 0,09897026 0,12137769 ! dendrite development GO:0016358 67 28 0,000 0,09897026 0,12131679 ! fat cell differentiation GO:0045444 57 28 0,000 0,09897026 0,12125595 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,09897026 0,12119517 ! sperm motility GO:0030317 37 28 0,000 0,09897026 0,12113445 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,09897026 0,12107379 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,09897026 0,12101319 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,09897026 0,12095265 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,09897026 0,12089218 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,09897026 0,12083176 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,09897026 0,12077141 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,09897026 0,12071111 ! glutathione metabolic process GO:0006749 42 28 0,000 0,09897026 0,12065088 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,09897026 0,1205907 ! lipid oxidation GO:0034440 48 28 0,000 0,09897026 0,12053059 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,09897026 0,12047053 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,09897026 0,12041054 ! translational initiation GO:0006413 66 29 0,000 0,10231906 0,12442283 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,10231906 0,12436093 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,10231906 0,12429909 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,10231906 0,12423731 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,10231906 0,12417559 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,10231906 0,12411394 ! primary neural tube formation GO:0014020 61 29 0,000 0,10231906 0,12405234 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,10231906 0,12399081 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,10231906 0,12392934 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,10231906 0,12386792 ! synaptogenesis GO:0007416 46 29 0,000 0,10231906 0,12380657 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,10231906 0,12374528 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,10231906 0,12368405 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,10231906 0,12362288 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,10565551 0,12759091 ! phenol metabolic process GO:0018958 56 30 0,000 0,10565551 0,12752787 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,10565551 0,12746489 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,10565551 0,12740198 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,10565551 0,12733913 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,10565551 0,12727634 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,10565551 0,12721361 ! acute-phase response GO:0006953 50 30 0,000 0,10565551 0,12715094 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,10565551 0,12708833 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,10565551 0,12702579 ! myofibril assembly GO:0030239 50 30 0,000 0,10565551 0,12696331 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,10565551 0,12690089 ! determination of left/right symmetry GO:0007368 53 30 0,000 0,10565551 0,12683853 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,10565551 0,12677623 ! phospholipid transport GO:0015914 65 30 0,000 0,10565551 0,12671399 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,10565551 0,12665182 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,10565551 0,1265897 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,10565551 0,12652765 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,10565551 0,12646566 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,10565551 0,12640373 GO:0048871|multicellular organismal homeostasis, ! alkaloid metabolic process GO:0009820 57 31 0,000 0,10897965 0,13031683 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,10897965 0,13025307 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,10897965 0,13018938 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,10897965 0,13012575 ! cell junction assembly GO:0034329 85 31 0,000 0,10897965 0,13006218 ! regulation of innate immune response GO:0045088 57 31 0,000 0,10897965 0,12999867 ! peptide transport GO:0015833 60 31 0,000 0,10897965 0,12993523 ! male gonad development GO:0008584 56 31 0,000 0,10897965 0,12987184 ! iron ion homeostasis GO:0055072 60 31 0,000 0,10897965 0,12980852 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,10897965 0,12974526 ! detection of light stimulus GO:0009583 44 31 0,000 0,10897965 0,12968206 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,10897965 0,12961893 ! ensheathment of neurons GO:0007272 64 31 0,000 0,10897965 0,12955585 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,10897965 0,12949284 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,10897965 0,12942989 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,10897965 0,129367 ! eye morphogenesis GO:0048592 65 31 0,000 0,10897965 0,12930417 ! response to heat GO:0009408 54 31 0,000 0,10897965 0,1292414 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,11229152 0,13310441 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,11229152 0,13303986 ! collagen metabolic process GO:0032963 49 32 0,000 0,11229152 0,13297537 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,11229152 0,13291095 ! spindle organization GO:0007051 50 32 0,000 0,11229152 0,13284658 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,11229152 0,13278228 ! metanephros development GO:0001656 81 32 0,000 0,11229152 0,13271804 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,11229152 0,13265387 ! muscle cell development GO:0055001 52 32 0,000 0,11229152 0,13258975 ! mesoderm formation GO:0001707 73 32 0,000 0,11229152 0,1325257 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,11229152 0,13246171 ! peripheral nervous system development GO:0007422 68 32 0,000 0,11229152 0,13239778 ! BMP signaling pathway GO:0030509 71 32 0,000 0,11229152 0,13233391 ! hindbrain development GO:0030902 65 32 0,000 0,11229152 0,1322701 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,11229152 0,13220636 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,11229152 0,13214268 ! gene silencing GO:0016458 71 32 0,000 0,11229152 0,13207905 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,11559118 0,13589474 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,11559118 0,13582937 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,11559118 0,13576407 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,11559118 0,13569883 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,11559118 0,13563365 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,11559118 0,13556854 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,11559118 0,13550349 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,11559118 0,1354385 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,11559118 0,13537357 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,11559118 0,1353087 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,11559118 0,1352439 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,11887867 0,13902374 ! glial cell differentiation GO:0010001 67 34 0,000 0,11887867 0,13895722 ! post-embryonic development GO:0009791 76 34 0,000 0,11887867 0,13889077 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,11887867 0,13882438 ! cholesterol transport GO:0030301 62 34 0,000 0,11887867 0,13875805 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,11887867 0,13869178 ! spliceosome assembly GO:0000245 75 34 0,000 0,11887867 0,13862558 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,11887867 0,13855944 ! formation of primary germ layer GO:0001704 76 34 0,000 0,11887867 0,13849337 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,11887867 0,13842736 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,11887867 0,13836141 ! adult locomotory behavior GO:0008344 62 34 0,000 0,11887867 0,13829552 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,12215403 0,14203822 ! negative regulation of secretion GO:0051048 68 35 0,000 0,12215403 0,14197065 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,12215403 0,14190314 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,12215403 0,14183569 ! membrane docking GO:0022406 69 35 0,000 0,12215403 0,14176831 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,12215403 0,141701 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,12215403 0,14163374 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,12215403 0,14156656 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,12215403 0,14149943 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,12215403 0,14143237 ! ceramide metabolic process GO:0006672 72 35 0,000 0,12215403 0,14136537 ! sterol transport GO:0015918 63 35 0,000 0,12215403 0,14129844 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,12215403 0,14123157 ! placenta development GO:0001890 53 35 0,000 0,12215403 0,14116476 ! vesicle localization GO:0051648 70 35 0,000 0,12215403 0,14109801 ! regulation of muscle development GO:0048634 82 36 0,000 0,12541731 0,1447989 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,12541731 0,14473051 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,12541731 0,14466217 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,12541731 0,1445939 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,12541731 0,1445257 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,12541731 0,14445756 ! positive regulation of cell development GO:0010720 85 36 0,000 0,12541731 0,14438948 ! regulation of proteolysis GO:0030162 77 36 0,000 0,12541731 0,14432147 ! aerobic respiration GO:0009060 56 36 0,000 0,12541731 0,14425352 ! cytokine production GO:0001816 68 36 0,000 0,12541731 0,14418564 ! embryonic organ development GO:0048568 67 36 0,000 0,12541731 0,14411782 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,12541731 0,14405006 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,12541731 0,14398237 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,12866854 0,14764549 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,12866854 0,14757618 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,12866854 0,14750692 ! sister chromatid segregation GO:0000819 65 37 0,000 0,12866854 0,14743774 ! odontogenesis GO:0042476 74 37 0,000 0,12866854 0,14736861 ! actomyosin structure organization GO:0031032 68 37 0,000 0,12866854 0,14729956 ! cell junction organization GO:0034330 96 37 0,000 0,12866854 0,14723056 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,12866854 0,14716164 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,12866854 0,14709277 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,12866854 0,14702397 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,12866854 0,14695524 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,13190779 0,15058445 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,13190779 0,15051412 ! organic anion transport GO:0015711 82 38 0,000 0,13190779 0,15044385 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,13190779 0,15037364 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,13190779 0,15030351 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,13190779 0,15023344 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,13190779 0,15016343 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,13190779 0,15009349 ! regulation of protein stability GO:0031647 77 38 0,000 0,13190779 0,15002361 ! glycogen metabolic process GO:0005977 63 38 0,000 0,13190779 0,1499538 ! pigment metabolic process GO:0042440 87 38 0,000 0,13190779 0,14988406 ! neural tube formation GO:0001841 79 38 0,000 0,13190779 0,14981437 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,13513508 0,15340845 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,13513508 0,1533372 ! negative regulation of binding GO:0051100 71 39 0,000 0,13513508 0,15326601 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,13513508 0,15319489 GO:0042593|glucose homeostasis, ! nucleotide catabolic process GO:0009166 70 39 0,000 0,13513508 0,15312384 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,13513508 0,15305285 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,13513508 0,15298192 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,13513508 0,15291107 ! glucan metabolic process GO:0044042 64 39 0,000 0,13513508 0,15284027 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,13835046 0,15640452 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,13835046 0,15633218 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,13835046 0,1562599 ! learning GO:0007612 82 40 0,000 0,13835046 0,15618769 ! nucleus organization GO:0006997 73 40 0,000 0,13835046 0,15611555 ! lipid homeostasis GO:0055088 75 40 0,000 0,13835046 0,15604348 ! mismatch repair GO:0006298 58 40 0,000 0,13835046 0,15597147 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,13835046 0,15589953 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,13835046 0,15582765 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,13835046 0,15575584 ! RNA export from nucleus GO:0006405 61 41 0,000 0,14155398 0,15928898 ! mRNA catabolic process GO:0006402 79 41 0,000 0,14155398 0,15921564 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,14155398 0,15914237 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,14155398 0,15906917 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,14155398 0,15899603 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,14155398 0,15892296 ! gliogenesis GO:0042063 91 41 0,000 0,14155398 0,15884996 ! feeding behavior GO:0007631 69 41 0,000 0,14155398 0,15877703 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,14155398 0,15870416 ! mesenchymal cell development GO:0014031 94 41 0,000 0,14155398 0,15863136 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,14155398 0,15855863 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,14155398 0,15848596 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,14155398 0,15841336 ! RNA modification GO:0009451 64 41 0,000 0,14155398 0,15834083 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,14474568 0,16183693 ! ear morphogenesis GO:0042471 64 42 0,000 0,14474568 0,16176289 ! organic ether metabolic process GO:0018904 59 42 0,000 0,14474568 0,16168893 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,14474568 0,16161503 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,14474568 0,1615412 ! regulation of protein secretion GO:0050708 77 42 0,000 0,14474568 0,16146744 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,14474568 0,16139374 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,14474568 0,16132011 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,1479256 0,16478898 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,1479256 0,16471387 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,1479256 0,16463883 ! regulation of tube size GO:0035150 76 43 0,000 0,1479256 0,16456386 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,1479256 0,16448896 ! glucose transport GO:0015758 66 43 0,000 0,1479256 0,16441412 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,1479256 0,16433935 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,1479256 0,16426465 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,1479256 0,16419002 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,1479256 0,16411546 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,1479256 0,16404096 ! ion transmembrane transport GO:0034220 79 43 0,000 0,1479256 0,16396653 ! neuron migration GO:0001764 85 43 0,000 0,1479256 0,16389217 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,1479256 0,16381788 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,15109379 0,16725062 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,15109379 0,16717487 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,15109379 0,16709919 ! hexose transport GO:0008645 68 44 0,000 0,15109379 0,16702358 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,15109379 0,16694804 ! striated muscle contraction GO:0006941 85 44 0,000 0,15109379 0,16687257 ! phagocytosis GO:0006909 105 44 0,000 0,15109379 0,16679716 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,15109379 0,16672182 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,15425028 0,17012796 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,15425028 0,17005119 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,15425028 0,16997449 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,15425028 0,16989785 ! biopolymer methylation GO:0043414 91 45 0,000 0,15425028 0,16982129 ! female gamete generation GO:0007292 71 45 0,000 0,15425028 0,16974479 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,15425028 0,16966836 ! polyol metabolic process GO:0019751 77 45 0,000 0,15425028 0,16959201 ! developmental growth GO:0048589 88 45 0,000 0,15425028 0,16951572 ! maintenance of location in cell GO:0051651 101 45 0,000 0,15425028 0,1694395 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,15739513 0,17281632 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,15739513 0,17273868 ! glycolysis GO:0006096 71 46 0,000 0,15739513 0,17266111 ! leukocyte migration GO:0050900 75 46 0,000 0,15739513 0,17258362 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,15739513 0,17250619 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,15739513 0,17242884 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,15739513 0,17235155 ! pigmentation GO:0043473 103 46 0,000 0,15739513 0,17227433 ! cell growth GO:0016049 90 46 0,000 0,15739513 0,17219718 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,15739513 0,1721201 ! neural tube development GO:0021915 91 47 0,000 0,16052837 0,17546793 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,16052837 0,17538945 ! positive regulation of defense response GO:0031349 88 48 0,000 0,16365005 0,1787202 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,16365005 0,17864034 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,16365005 0,17856055 ! cellular component disassembly GO:0022411 89 48 0,000 0,16365005 0,17848084 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,16365005 0,17840119 ! endosome transport GO:0016197 127 48 0,000 0,16365005 0,17832162 ! male sex differentiation GO:0046661 93 48 0,000 0,16365005 0,17824212 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,16365005 0,17816269 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,16365005 0,17808333 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,16365005 0,17800404 ! methylation GO:0032259 97 48 0,000 0,16365005 0,17792482 ! response to calcium ion GO:0051592 94 49 0,000 0,16676021 0,18122562 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,16676021 0,18114504 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,16676021 0,18106453 ! regulation of action potential GO:0001508 102 50 0,000 0,16985889 0,18434708 ! regulation of ion transport GO:0043269 86 50 0,000 0,16985889 0,18426522 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,16985889 0,18418343 ! regulation of ossification GO:0030278 123 50 0,000 0,16985889 0,18410172 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,16985889 0,18402008 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,16985889 0,18393851 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,16985889 0,18385701 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,16985889 0,18377558 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,16985889 0,18369423 ! peptide metabolic process GO:0006518 80 51 0,000 0,17294613 0,18695018 ! response to temperature stimulus GO:0009266 84 51 0,000 0,17294613 0,18686749 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,17294613 0,18678488 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,17602198 0,19002285 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,17602198 0,18993892 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,17602198 0,18985506 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,17602198 0,18977127 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,17602198 0,18968756 ! excretion GO:0007588 87 52 0,000 0,17602198 0,18960393 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,17602198 0,18952036 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,17602198 0,18943687 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,17602198 0,18935346 ! amino acid activation GO:0043038 98 52 0,000 0,17602198 0,18927012 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,17908648 0,19248054 ! positive regulation of growth GO:0045927 96 53 0,000 0,17908648 0,1923959 ! chromatin remodeling GO:0006338 122 53 0,000 0,17908648 0,19231133 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,17908648 0,19222683 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,17908648 0,19214241 ! vesicle organization GO:0016050 127 53 0,000 0,17908648 0,19205806 ! cartilage development GO:0051216 99 53 0,000 0,17908648 0,19197379 ! synapse organization GO:0050808 102 53 0,000 0,17908648 0,19188959 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,18213966 0,19507549 ! regulation of translational initiation GO:0006446 87 54 0,000 0,18213966 0,19499001 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,18213966 0,1949046 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,18213966 0,19481926 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,18213966 0,194734 ! membrane fusion GO:0006944 122 54 0,000 0,18213966 0,19464882 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,18213966 0,19456371 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,18213966 0,19447867 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,18213966 0,19439371 ! RNA catabolic process GO:0006401 103 55 0,000 0,18518158 0,19755397 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,18518158 0,19746774 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,18518158 0,19738159 ! cell recognition GO:0008037 98 55 0,000 0,18518158 0,19729551 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,18518158 0,1972095 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,18518158 0,19712357 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,18518158 0,19703772 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,18821227 0,20017526 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,18821227 0,20008815 ! glucose catabolic process GO:0006007 88 56 0,000 0,18821227 0,20000112 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,18821227 0,19991416 ! RNA elongation GO:0006354 90 56 0,000 0,18821227 0,19982728 ! chloride transport GO:0006821 102 57 0,000 0,19123176 0,20294492 ! muscle fiber development GO:0048747 131 57 0,000 0,19123176 0,2028568 ! heart morphogenesis GO:0003007 105 57 0,000 0,19123176 0,20276875 ! regulation of actin filament length GO:0030832 118 58 0,000 0,19424012 0,20586924 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,19424012 0,20577997 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,19424012 0,20569077 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,19424012 0,20560165 ! gastrulation GO:0007369 122 58 0,000 0,19424012 0,20551261 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,19424012 0,20542364 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,19424012 0,20533475 ! maintenance of location GO:0051235 124 58 0,000 0,19424012 0,20524594 ! nuclear export GO:0051168 110 59 0,000 0,19723736 0,20832291 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,20022355 0,21138553 ! DNA catabolic process GO:0006308 94 60 0,000 0,20022355 0,21129422 ! regulation of endocytosis GO:0030100 104 60 0,000 0,20022355 0,21120299 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,20022355 0,21111184 ! adult behavior GO:0030534 104 60 0,000 0,20022355 0,21102076 ! kidney development GO:0001822 133 60 0,000 0,20022355 0,21092976 ! positive regulation of secretion GO:0051047 110 61 0,000 0,2031987 0,21397174 ! regulation of cellular component size GO:0032535 125 61 0,000 0,2031987 0,21387955 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,2031987 0,21378744 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,2031987 0,21369541 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,2031987 0,21360346 ! regulation of heart contraction GO:0008016 123 61 0,000 0,2031987 0,21351158 ! camera-type eye development GO:0043010 126 61 0,000 0,2031987 0,21341979 ! proton transport GO:0015992 117 61 0,000 0,2031987 0,21332808 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,20616288 0,21634704 ! tRNA processing GO:0008033 102 62 0,000 0,20616288 0,21625415 ! mesoderm development GO:0007498 128 63 0,000 0,20911611 0,21925779 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,20911611 0,21916373 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,20911611 0,21906975 ! hydrogen transport GO:0006818 121 64 0,000 0,21205843 0,2220569 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,21205843 0,22196176 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,21205843 0,2218667 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,2149899 0,22483746 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,2149899 0,22474126 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,2149899 0,22464513 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,2149899 0,22454909 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,21791053 0,22750232 ! chromosome segregation GO:0007059 127 67 0,000 0,22082039 0,23044178 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,22082039 0,23034339 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,22082039 0,23024507 ! secondary metabolic process GO:0019748 125 67 0,000 0,22082039 0,23014685 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,2237195 0,23306897 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,2237195 0,23296962 ! hexose catabolic process GO:0019320 113 68 0,000 0,2237195 0,23287036 ! extracellular matrix organization GO:0030198 146 68 0,000 0,2237195 0,23277118 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,2237195 0,23267209 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,2237195 0,23257308 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,2266079 0,23547559 ! urogenital system development GO:0001655 149 69 0,000 0,2266079 0,23537547 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,2266079 0,23527544 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,2266079 0,23517549 ! single fertilization GO:0007338 83 69 0,000 0,2266079 0,23507563 ! cell redox homeostasis GO:0045454 114 70 0,000 0,22948564 0,23795986 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,22948564 0,2378589 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,23235275 0,24072849 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,23235275 0,24062644 ! carbohydrate transport GO:0008643 114 72 0,000 0,23520927 0,24348146 ! actin filament organization GO:0007015 167 72 0,000 0,23520927 0,24337834 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,23520927 0,2432753 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,23520927 0,24317235 ! humoral immune response GO:0006959 115 73 0,000 0,23805525 0,24601056 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,23805525 0,24590654 ! acute inflammatory response GO:0002526 118 74 0,000 0,24089071 0,24873035 ! amino acid transport GO:0006865 148 74 0,000 0,24089071 0,24862527 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,24089071 0,24852027 ! transition metal ion transport GO:0000041 143 75 0,000 0,2437157 0,2513286 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,2437157 0,25122256 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,2437157 0,2511166 ! axon guidance GO:0007411 162 75 0,000 0,2437157 0,25101073 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,24653026 0,25380254 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,24653026 0,25369563 ! learning or memory GO:0007611 161 76 0,000 0,24653026 0,25358881 ! regulation of blood pressure GO:0008217 134 76 0,000 0,24653026 0,25348208 ! amine catabolic process GO:0009310 136 77 0,000 0,24933442 0,25625746 ! neurotransmitter transport GO:0006836 142 77 0,000 0,24933442 0,2561497 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,24933442 0,25604203 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,24933442 0,25593445 ! regulation of catabolic process GO:0009894 173 77 0,000 0,24933442 0,25582696 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,25212822 0,25858491 ! antigen processing and presentation GO:0019882 117 78 0,000 0,25212822 0,2584764 ! fertilization GO:0009566 99 78 0,000 0,25212822 0,25836798 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,25491171 0,26111082 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,25491171 0,26100139 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,25491171 0,26089204 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,25491171 0,26078279 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,25768491 0,26350952 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,25768491 0,26339926 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,25768491 0,2632891 ! muscle cell differentiation GO:0042692 178 81 0,000 0,26044787 0,2660009 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,26044787 0,26588974 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,26320063 0,26858777 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,26594321 0,27127318 ! exocytosis GO:0006887 153 83 0,000 0,26594321 0,27115996 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,26594321 0,27104683 ! inorganic anion transport GO:0015698 156 83 0,000 0,26594321 0,2709338 ! response to metal ion GO:0010038 158 84 0,000 0,26867566 0,27360344 ! response to nutrient GO:0007584 135 84 0,000 0,26867566 0,27348943 ! digestion GO:0007586 130 84 0,000 0,26867566 0,27337553 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,27139802 0,27603054 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,27139802 0,27591567 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,27139802 0,2758009 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,27411032 0,27844138 ! regulation of lyase activity GO:0051339 169 86 0,000 0,27411032 0,27832565 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,2768126 0,28095271 ! alcohol catabolic process GO:0046164 142 87 0,000 0,2768126 0,28083604 ! nucleosome assembly GO:0006334 126 87 0,000 0,2768126 0,28071946 ! cellular respiration GO:0045333 143 88 0,000 0,2795049 0,28333214 ! amine biosynthetic process GO:0009309 146 88 0,000 0,2795049 0,28321463 ! sensory perception of smell GO:0007608 117 88 0,000 0,2795049 0,28309721 ! chromatin assembly GO:0031497 128 88 0,000 0,2795049 0,28297988 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,2795049 0,28286266 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,28218724 0,28545898 ! tube morphogenesis GO:0035239 194 89 0,000 0,28218724 0,28534083 ! cellular defense response GO:0006968 123 89 0,000 0,28218724 0,28522277 ! regulation of neurological system process GO:0031644 175 89 0,000 0,28218724 0,28510481 ! response to inorganic substance GO:0010035 173 90 0,000 0,28485968 0,28768591 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,28485968 0,28756703 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,28485968 0,28744825 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,28752225 0,29001521 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,28752225 0,28989552 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,29017497 0,29244944 ! regulation of cell adhesion GO:0030155 241 92 0,000 0,29017497 0,29232885 ! amine transport GO:0015837 181 93 0,000 0,29281789 0,29486979 ! vitamin metabolic process GO:0006766 153 93 0,000 0,29281789 0,2947483 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,29545105 0,29727632 ! female pregnancy GO:0007565 166 94 0,000 0,29545105 0,29715394 ! sterol metabolic process GO:0016125 166 94 0,000 0,29545105 0,29703165 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,29545105 0,29690947 ! regulation of membrane potential GO:0042391 179 94 0,000 0,29545105 0,29678738 ! regulation of defense response GO:0031347 171 95 0,000 0,29807448 0,29929961 ! nucleosome organization GO:0034728 143 95 0,000 0,29807448 0,29917664 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,29807448 0,29905378 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,29807448 0,29893101 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,29807448 0,29880835 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,29807448 0,29868579 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,30329228 0,30378969 ! transcription initiation GO:0006352 171 97 0,000 0,30329228 0,30366518 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,30588673 0,30613735 ! mRNA transport GO:0051028 185 100 0,000 0,3110469 0,31117427 ! hormone metabolic process GO:0042445 171 100 0,000 0,3110469 0,3110469