pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/811-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of epithelial cell proliferation GO:0050679 37 19 3,000 1,197E-07 2,753E-04 ! positive regulation of osteoblast differentiation GO:0045669 33 20 3,000 1,494E-07 1,718E-04 ! lung development GO:0030324 94 59 4,000 3,213E-07 2,463E-04 ! regulation of osteoblast differentiation GO:0045667 37 24 3,000 3,252E-07 1,87E-04 ! respiratory tube development GO:0030323 99 62 4,000 4,13E-07 1,9E-04 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 2,000 4,818E-07 1,847E-04 ! respiratory system development GO:0060541 100 64 4,000 4,849E-07 1,593E-04 ! mesoderm formation GO:0001707 46 28 3,000 6,222E-07 1,789E-04 ! BMP signaling pathway GO:0030509 40 28 3,000 6,222E-07 1,59E-04 ! formation of primary germ layer GO:0001704 48 29 3,000 7,205E-07 1,657E-04 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 4,000 7,614E-07 1,592E-04 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 2,000 7,696E-07 1,475E-04 ! mesoderm morphogenesis GO:0048332 49 31 3,000 9,511E-07 1,683E-04 ! detection of bacterium GO:0016045 10 10 2,000 1,643E-06 2,7E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 2,451E-06 3,758E-04 ! positive regulation of bone mineralization GO:0030501 19 13 2,000 3,897E-06 5,602E-04 ! regulation of ossification GO:0030278 71 46 3,000 4,802E-06 6,497E-04 ! positive regulation of biomineral formation GO:0070169 20 14 2,000 4,951E-06 6,326E-04 ! gastrulation GO:0007369 73 48 3,000 5,706E-06 6,907E-04 ! detection of biotic stimulus GO:0009595 19 16 2,000 7,591E-06 8,73E-04 ! regulation of bone remodeling GO:0046850 90 53 3,000 8,511E-06 9,321E-04 ! regulation of tissue remodeling GO:0034103 91 54 3,000 9,175E-06 9,592E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 9,202E-06 9,202E-04 ! mesoderm development GO:0007498 76 55 3,000 9,877E-06 9,465E-04 ! positive regulation of ossification GO:0045778 30 19 2,000 1,307E-05 1,202E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 1,307E-05 1,156E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,535E-05 1,307E-03 ! positive regulation of bone remodeling GO:0046852 33 21 2,000 1,787E-05 1,468E-03 GO:0034105|positive regulation of tissue remodeling, ! regulation of vasoconstriction GO:0019229 31 21 2,000 1,787E-05 1,418E-03 ! regulation of bone mineralization GO:0030500 29 21 2,000 1,787E-05 1,37E-03 ! osteoblast differentiation GO:0001649 40 23 2,000 2,372E-05 1,76E-03 ! regulation of biomineral formation GO:0070167 31 23 2,000 2,372E-05 1,705E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 2,706E-05 1,886E-03 ! steroid biosynthetic process GO:0006694 94 71 3,000 2,735E-05 1,85E-03 ! ossification GO:0001503 134 82 3,000 4,827E-05 3,172E-03 GO:0060348|bone development, ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 1,000 5,882E-05 3,758E-03 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 1,000 5,882E-05 3,656E-03 ! positive regulation of vasoconstriction GO:0045907 9 5 1,000 5,882E-05 3,56E-03 ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 5,882E-05 3,469E-03 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 8,587E-05 4,938E-03 ! protein homooligomerization GO:0051260 52 35 2,000 8,587E-05 4,817E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 8,809E-05 4,824E-03 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 1,000 8,809E-05 4,712E-03 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! ER overload response GO:0006983 7 6 1,000 8,809E-05 4,605E-03 ! male sex determination GO:0030238 9 6 1,000 8,809E-05 4,502E-03 ! gas homeostasis GO:0033483 11 6 1,000 8,809E-05 4,405E-03 ! midbrain development GO:0030901 6 6 1,000 8,809E-05 4,311E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 8,809E-05 4,221E-03 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 8,809E-05 4,135E-03 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 8,809E-05 4,052E-03 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 2,000 1,101E-04 4,966E-03 ! male sex differentiation GO:0046661 53 39 2,000 1,191E-04 5,267E-03 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 1,231E-04 5,344E-03 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 1,000 1,231E-04 5,245E-03 ! vesicle fusion GO:0006906 15 7 1,000 1,231E-04 5,149E-03 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 1,000 1,231E-04 5,057E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,231E-04 4,969E-03 ! positive regulation of protein transport GO:0051222 55 40 2,000 1,285E-04 5,097E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 1,488E-04 5,802E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,639E-04 6,284E-03 ! regulation of smoothened signaling pathway GO:0008589 13 8 1,000 1,639E-04 6,181E-03 ! induction of an organ GO:0001759 11 8 1,000 1,639E-04 6,081E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 1,639E-04 5,985E-03 ! regulation of translational initiation GO:0006446 64 45 2,000 1,83E-04 6,577E-03 ! regulation of protein polymerization GO:0032271 71 47 2,000 2,084E-04 7,375E-03 ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 2,104E-04 7,333E-03 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 2,104E-04 7,224E-03 ! lung alveolus development GO:0048286 17 9 1,000 2,104E-04 7,117E-03 ! endoderm development GO:0007492 12 9 1,000 2,104E-04 7,014E-03 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 2,104E-04 6,914E-03 ! localization within membrane GO:0051668 15 9 1,000 2,104E-04 6,817E-03 ! regulation of intracellular transport GO:0032386 78 49 2,000 2,36E-04 7,539E-03 ! cartilage development GO:0051216 70 49 2,000 2,36E-04 7,436E-03 ! negative regulation of blood pressure GO:0045776 22 10 1,000 2,626E-04 8,163E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,626E-04 8,054E-03 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 2,626E-04 7,948E-03 ! embryonic gut development GO:0048566 11 10 1,000 2,626E-04 7,845E-03 ! developmental induction GO:0031128 13 10 1,000 2,626E-04 7,744E-03 GO:0045168|cell-cell signaling involved in cell fate specification, ! regulation of protein complex assembly GO:0043254 81 54 2,000 3,15E-04 9,172E-03 ! detection of external stimulus GO:0009581 66 54 2,000 3,15E-04 9,057E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 3,205E-04 9,1E-03 ! chondrocyte differentiation GO:0002062 17 11 1,000 3,205E-04 8,989E-03 ! stem cell development GO:0048864 29 11 1,000 3,205E-04 8,881E-03 GO:0019827|stem cell maintenance, ! palate development GO:0060021 15 12 1,000 3,84E-04 0,01051384 ! gland morphogenesis GO:0022612 23 12 1,000 3,84E-04 0,01039014 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 4,531E-04 0,01211753 ! lipid localization GO:0010876 24 13 1,000 4,531E-04 0,01197825 GO:0019915|lipid storage, ! organelle fusion GO:0048284 28 13 1,000 4,531E-04 0,01184213 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,531E-04 0,01170907 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 4,531E-04 0,01157897 ! appendage morphogenesis GO:0035107 93 64 2,000 5,202E-04 0,01314733 GO:0035108|limb morphogenesis, ! heterophilic cell adhesion GO:0007157 29 14 1,000 5,278E-04 0,0131945 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 5,278E-04 0,01305263 ! appendage development GO:0048736 94 65 2,000 5,444E-04 0,01332079 GO:0060173|limb development, ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 5,444E-04 0,01318057 ! protein oligomerization GO:0051259 100 65 2,000 5,444E-04 0,01304328 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 6,08E-04 0,01441712 ! regulation of vasodilation GO:0042312 24 15 1,000 6,08E-04 0,01427001 ! regulation of peptidase activity GO:0052547 106 72 2,000 7,345E-04 0,01706395 ! response to hypoxia GO:0001666 132 72 2,000 7,345E-04 0,01689331 ! inactivation of MAPK activity GO:0000188 27 17 1,000 7,851E-04 0,01787813 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 7,851E-04 0,01770286 ! stem cell differentiation GO:0048863 36 17 1,000 7,851E-04 0,01753098 ! synaptogenesis GO:0007416 24 17 1,000 7,851E-04 0,01736242 ! peptidyl-serine modification GO:0018209 27 17 1,000 7,851E-04 0,01719706 ! response to oxygen levels GO:0070482 137 74 2,000 7,956E-04 0,01726324 ! protein import into nucleus GO:0006606 118 74 2,000 7,956E-04 0,0171019 ! nuclear import GO:0051170 121 75 2,000 8,273E-04 0,01761939 ! regulation of protein transport GO:0051223 114 76 2,000 8,599E-04 0,01814416 GO:0070201|regulation of establishment of protein localization, ! axis specification GO:0009798 26 18 1,000 8,818E-04 0,01843849 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 8,818E-04 0,01827238 ! gut development GO:0048565 26 18 1,000 8,818E-04 0,01810923 ! sex differentiation GO:0007548 105 77 2,000 8,932E-04 0,01818033 ! sex determination GO:0007530 29 19 1,000 9,84E-04 0,01985363 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 9,84E-04 0,01968099 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 9,84E-04 0,01951132 ! protein localization in nucleus GO:0034504 133 80 2,000 9,981E-04 0,01962069 ! detection of stimulus GO:0051606 108 82 2,000 1,072E-03 0,02089832 ! hindlimb morphogenesis GO:0035137 32 20 1,000 1,092E-03 0,02109975 ! collagen catabolic process GO:0030574 25 20 1,000 1,092E-03 0,02092392 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 1,19E-03 0,02261363 ! regulation of protein localization GO:0032880 132 85 2,000 1,19E-03 0,02242827 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 1,19E-03 0,02224592 ! vesicle docking GO:0048278 27 21 1,000 1,205E-03 0,02234553 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 1,205E-03 0,02216676 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 1,000 1,205E-03 0,02199084 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 1,323E-03 0,02396203 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 1,323E-03 0,02377483 ! vasculogenesis GO:0001570 33 22 1,000 1,323E-03 0,02359053 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 1,323E-03 0,02340906 ! barbed-end actin filament capping GO:0051016 33 22 1,000 1,323E-03 0,02323036 GO:0051693|actin filament capping, ! membrane depolarization GO:0051899 35 22 1,000 1,323E-03 0,02305438 ! regulation of blood coagulation GO:0030193 34 22 1,000 1,323E-03 0,02288104 ! reproductive developmental process GO:0003006 127 89 2,000 1,359E-03 0,02331847 ! embryonic pattern specification GO:0009880 31 23 1,000 1,447E-03 0,02465043 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 1,447E-03 0,02446918 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 1,447E-03 0,02429057 ! cell fate commitment GO:0045165 141 92 2,000 1,495E-03 0,02491044 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 1,542E-03 0,02551202 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 1,576E-03 0,02589056 ! negative regulation of cell development GO:0010721 56 24 1,000 1,576E-03 0,02570694 GO:0050768|negative regulation of neurogenesis, ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 1,576E-03 0,0255259 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 1,689E-03 0,02716506 ! negative regulation of actin filament depolymerization GO:0030835 36 25 1,000 1,71E-03 0,02731755 ! negative regulation of actin filament polymerization GO:0030837 36 25 1,000 1,71E-03 0,02712916 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 1,71E-03 0,02694334 ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 1,71E-03 0,02676005 ! male gonad development GO:0008584 33 25 1,000 1,71E-03 0,02657924 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 1,71E-03 0,02640086 ! protein import GO:0017038 156 99 2,000 1,845E-03 0,02828413 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 1,85E-03 0,02817813 ! multicellular organismal catabolic process GO:0044243 32 26 1,000 1,85E-03 0,02799275 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 1,85E-03 0,02780979 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 1,85E-03 0,02762921 ! negative regulation of protein polymerization GO:0032272 38 26 1,000 1,85E-03 0,02745096 ! regulation of coagulation GO:0050818 39 26 1,000 1,85E-03 0,02727499 ! protein localization in organelle GO:0033365 161 100 2,000 1,898E-03 0,02781134 ! regulation of translation GO:0006417 151 100 2,000 1,898E-03 0,02763532 ! homophilic cell adhesion GO:0007156 149 100 2,000 1,898E-03 0,02746151 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 1,995E-03 0,02867582 ! membrane docking GO:0022406 39 27 1,000 1,995E-03 0,02849771 ! inner ear morphogenesis GO:0042472 35 27 1,000 1,995E-03 0,0283218 ! negative regulation of protein complex assembly GO:0031333 42 28 1,000 2,145E-03 0,03026606 ! cholesterol homeostasis GO:0042632 46 28 1,000 2,145E-03 0,03008151 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 1,000 2,145E-03 0,0298992 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 2,145E-03 0,02971908 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 2,145E-03 0,02954112 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 2,3E-03 0,03149137 ! collagen metabolic process GO:0032963 40 30 1,000 2,461E-03 0,03348887 ! cholesterol transport GO:0030301 46 30 1,000 2,461E-03 0,03329188 GO:0015918|sterol transport, ! hindbrain development GO:0030902 45 30 1,000 2,461E-03 0,03309719 ! regulation of microtubule-based process GO:0032886 58 30 1,000 2,461E-03 0,03290476 ! mammary gland development GO:0030879 57 31 1,000 2,626E-03 0,03491629 ! odontogenesis GO:0042476 50 31 1,000 2,626E-03 0,03471562 ! cell fate specification GO:0001708 37 31 1,000 2,626E-03 0,03451725 ! neutral lipid metabolic process GO:0006638 41 32 1,000 2,797E-03 0,03655221 GO:0006639|acylglycerol metabolic process, ! calcium-mediated signaling GO:0019722 50 32 1,000 2,797E-03 0,0363457 ! ear morphogenesis GO:0042471 42 33 1,000 2,973E-03 0,03841334 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 2,973E-03 0,03819874 ! lipid homeostasis GO:0055088 55 33 1,000 2,973E-03 0,03798653 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 3,154E-03 0,04007524 ! glycerol ether metabolic process GO:0006662 44 34 1,000 3,154E-03 0,03985504 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 3,154E-03 0,03963726 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 3,154E-03 0,03942184 ! embryonic organ development GO:0048568 45 34 1,000 3,154E-03 0,03920874 ! glycogen metabolic process GO:0005977 48 35 1,000 3,34E-03 0,0412971 ! organic ether metabolic process GO:0018904 46 36 1,000 3,531E-03 0,04342485 ! tissue remodeling GO:0048771 62 36 1,000 3,531E-03 0,04319386 ! glucan metabolic process GO:0044042 49 36 1,000 3,531E-03 0,04296533 GO:0006073|cellular glucan metabolic process, ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 4,133E-03 0,05003525 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 4,133E-03 0,04977329 ! cell growth GO:0016049 61 39 1,000 4,133E-03 0,04951405 ! synapse organization GO:0050808 55 39 1,000 4,133E-03 0,0492575 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 4,344E-03 0,05150254 ! inner ear development GO:0048839 57 40 1,000 4,344E-03 0,05123842 ! energy reserve metabolic process GO:0006112 59 41 1,000 4,56E-03 0,0535079 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 4,78E-03 0,05581122 ! embryonic skeletal system development GO:0048706 56 42 1,000 4,78E-03 0,05552935 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 5,006E-03 0,05785539 ! vesicle organization GO:0016050 79 43 1,000 5,006E-03 0,05756612 ! positive regulation of cell cycle GO:0045787 77 45 1,000 5,471E-03 0,06260338 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 5,471E-03 0,06229346 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 5,711E-03 0,06470351 ! response to UV GO:0009411 75 46 1,000 5,711E-03 0,06438634 ! regulation of muscle contraction GO:0006937 69 48 1,000 6,205E-03 0,06961277 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 6,205E-03 0,06927484 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 6,205E-03 0,06894018 ! regulation of actin filament length GO:0030832 72 50 1,000 6,717E-03 0,07427744 ! ear development GO:0043583 72 50 1,000 6,717E-03 0,07392205 ! membrane fusion GO:0006944 80 50 1,000 6,717E-03 0,07357004 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 6,717E-03 0,07322137 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 6,981E-03 0,07573279 ! activation of phospholipase C activity GO:0007202 87 51 1,000 6,981E-03 0,07537724 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of cell migration GO:0030335 92 51 1,000 6,981E-03 0,07502501 ! positive regulation of organelle organization GO:0010638 82 51 1,000 6,981E-03 0,07467605 ! regulation of cellular component size GO:0032535 74 52 1,000 7,249E-03 0,07718358 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 7,249E-03 0,0768279 ! regulation of phospholipase activity GO:0010517 90 54 1,000 7,798E-03 0,08227534 ! positive regulation of lipase activity GO:0060193 90 54 1,000 7,798E-03 0,08189966 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 8,366E-03 0,08746543 ! positive regulation of cell motion GO:0051272 99 56 1,000 8,366E-03 0,08706966 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 8,657E-03 0,08969008 ! developmental maturation GO:0021700 75 57 1,000 8,657E-03 0,08928788 ! gonad development GO:0008406 79 57 1,000 8,657E-03 0,08888927 ! negative regulation of kinase activity GO:0033673 100 58 1,000 8,952E-03 0,09151262 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 9,556E-03 0,09725416 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of transferase activity GO:0051348 105 61 1,000 9,865E-03 0,09995283 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,01049537 0,10587431 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01049537 0,10541198 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,01081715 0,10817147 ! reproductive structure development GO:0048608 90 65 1,000 0,01114327 0,11095026 ! regulation of caspase activity GO:0043281 97 65 1,000 0,01114327 0,11047202 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,0114737 0,11325969 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,01180843 0,11606574 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,01214743 0,11888971 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01223941 0,11928235 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01223941 0,11877905 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01223941 0,11827998 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01223941 0,11778508 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01223941 0,11729431 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01223941 0,11680761 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01223941 0,11632493 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01223941 0,11584623 ! sleep GO:0030431 11 5 0,000 0,01223941 0,11537145 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01223941 0,11490055 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01223941 0,11443347 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01223941 0,11397018 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01223941 0,11351062 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01223941 0,11305476 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01223941 0,11260254 ! tongue development GO:0043586 6 5 0,000 0,01223941 0,11215392 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01223941 0,11170887 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01223941 0,11126733 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01223941 0,11082927 ! cobalt ion transport GO:0006824 9 5 0,000 0,01223941 0,11039464 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01223941 0,10996341 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01223941 0,10953554 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01223941 0,10911099 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01223941 0,10868971 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01223941 0,10827167 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01223941 0,10785684 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01223941 0,10744517 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01223941 0,10703663 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01223941 0,10663119 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01223941 0,10622881 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01223941 0,10582945 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01223941 0,10543309 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01223941 0,10503968 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01223941 0,1046492 ! malate metabolic process GO:0006108 7 5 0,000 0,01223941 0,10426161 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01223941 0,10387688 ! behavioral response to pain GO:0048266 7 5 0,000 0,01223941 0,10349498 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01223941 0,10311588 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01223941 0,10273954 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01223941 0,10236594 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01223941 0,10199505 ! mating behavior GO:0007617 6 5 0,000 0,01223941 0,10162684 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01223941 0,10126127 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01223941 0,10089833 ! rhythmic behavior GO:0007622 12 5 0,000 0,01223941 0,10053798 ! copulation GO:0007620 7 5 0,000 0,01223941 0,10018019 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01223941 0,09982494 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01223941 0,09947221 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01223941 0,09912195 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01223941 0,09877416 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01223941 0,09842879 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01223941 0,09808583 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01223941 0,09774526 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01223941 0,09740704 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01223941 0,09707115 ! response to protozoan GO:0001562 9 5 0,000 0,01223941 0,09673757 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,01223941 0,09640628 ! lymph vessel development GO:0001945 7 5 0,000 0,01223941 0,09607725 ! endochondral ossification GO:0001958 12 5 0,000 0,01223941 0,09575046 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01223941 0,09542588 ! parathyroid gland development GO:0060017 8 5 0,000 0,01223941 0,09510349 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01223941 0,09478328 ! anagen GO:0042640 6 5 0,000 0,01223941 0,09446522 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01223941 0,09414928 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01223941 0,09383545 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01223941 0,0935237 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01223941 0,09321402 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01223941 0,09290638 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01223941 0,09260077 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01223941 0,09229716 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01223941 0,09199554 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01223941 0,09169588 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01223941 0,09139816 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01223941 0,09110238 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01223941 0,0908085 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01223941 0,09051651 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01223941 0,09022639 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01223941 0,08993813 ! ovulation GO:0030728 6 5 0,000 0,01223941 0,0896517 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01223941 0,08936709 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01223941 0,08908429 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01223941 0,08880326 ! response to pH GO:0009268 9 5 0,000 0,01223941 0,08852401 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01223941 0,0882465 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01223941 0,08797073 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01223941 0,08769668 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01223941 0,08742433 ! polyol catabolic process GO:0046174 7 5 0,000 0,01223941 0,08715367 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01223941 0,08688467 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01223941 0,08661734 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01223941 0,08635164 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01223941 0,08608757 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01223941 0,0858251 ! urea metabolic process GO:0019627 6 5 0,000 0,01223941 0,08556424 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01223941 0,08530495 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01223941 0,08504723 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01223941 0,08479107 ! neutrophil activation GO:0042119 5 5 0,000 0,01223941 0,08453644 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01223941 0,08428334 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01223941 0,08403174 ! response to food GO:0032094 5 5 0,000 0,01223941 0,08378165 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01223941 0,08353304 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01223941 0,0832859 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01223941 0,08304022 ! forebrain neuron development GO:0021884 7 5 0,000 0,01223941 0,08279598 ! melanosome organization GO:0032438 7 5 0,000 0,01223941 0,08255318 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01223941 0,0823118 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01223941 0,08207182 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01223941 0,08183324 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01223941 0,08159604 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01223941 0,08136021 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01223941 0,08112575 ! nucleoside transport GO:0015858 6 5 0,000 0,01223941 0,08089263 ! nucleoside salvage GO:0043174 7 5 0,000 0,01223941 0,08066084 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01223941 0,08043038 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01223941 0,08020124 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01223941 0,07997339 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01223941 0,07974684 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01223941 0,07952157 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01223941 0,07929756 ! depyrimidination GO:0045008 8 5 0,000 0,01223941 0,07907482 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01223941 0,07885332 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01223941 0,07863306 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01223941 0,07841402 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01223941 0,07819621 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01223941 0,0779796 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01223941 0,07776418 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01223941 0,07754996 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01223941 0,07733691 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01223941 0,07712503 ! monocyte differentiation GO:0030224 8 5 0,000 0,01223941 0,0769143 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01223941 0,07670473 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01223941 0,07649629 ! centrosome duplication GO:0051298 5 5 0,000 0,01223941 0,07628898 ! response to UV-C GO:0010225 6 5 0,000 0,01223941 0,0760828 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01223941 0,07587772 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01223941 0,07567375 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01223941 0,07547087 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01223941 0,07526908 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01223941 0,07506836 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01223941 0,07486871 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01223941 0,07467012 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01223941 0,07447258 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01223941 0,07427608 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01223941 0,07408062 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01223941 0,07388618 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01223941 0,07369276 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01223941 0,07350035 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01223941 0,07330894 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01223941 0,07311853 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01223941 0,0729291 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01223941 0,07274066 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01223941 0,07255318 ! neural tube patterning GO:0021532 6 5 0,000 0,01223941 0,07236667 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01223941 0,07218111 ! histone demethylation GO:0016577 9 5 0,000 0,01223941 0,07199651 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01223941 0,07181284 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01223941 0,07163011 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01223941 0,07144831 ! enteric nervous system development GO:0048484 8 5 0,000 0,01223941 0,07126743 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01223941 0,07108746 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01223941 0,0709084 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01223941 0,07073024 ! transcription termination GO:0006353 8 5 0,000 0,01223941 0,07055297 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01223941 0,07037659 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01223941 0,07020108 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01223941 0,07002645 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,01223941 0,06985269 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01223941 0,06967979 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01223941 0,06950774 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01223941 0,06933654 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01223941 0,06916618 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01223941 0,06899665 ! apical protein localization GO:0045176 6 5 0,000 0,01223941 0,06882796 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01223941 0,06866008 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01223941 0,06849303 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01223941 0,06832678 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01223941 0,06816134 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01223941 0,0679967 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01223941 0,06783285 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01223941 0,06766979 ! glial cell migration GO:0008347 10 5 0,000 0,01223941 0,06750752 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01223941 0,06734601 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01223941 0,06718528 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01223941 0,06702532 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01223941 0,06686611 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01223941 0,06670766 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01223941 0,06654996 ! neural plate development GO:0001840 6 5 0,000 0,01223941 0,06639301 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01223941 0,06623679 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01223941 0,0660813 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01223941 0,06592654 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01223941 0,06577251 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01223941 0,06561919 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01223941 0,06546659 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01223941 0,0653147 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01223941 0,06516351 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01223941 0,06501301 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01223941 0,06486321 ! spindle assembly GO:0051225 5 5 0,000 0,01223941 0,0647141 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01223941 0,06456567 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01223941 0,06441793 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01223941 0,06427085 ! organ regeneration GO:0031100 7 5 0,000 0,01223941 0,06412445 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01223941 0,06397871 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01223941 0,06383364 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01223941 0,06368922 GO:0055081|anion homeostasis, ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,01283815 0,06665407 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,0135457 0,07016919 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,0135457 0,0700115 ! regulation of blood pressure GO:0008217 107 73 1,000 0,01390573 0,07171118 ! tRNA transcription GO:0009304 11 6 0,000 0,01466967 0,07548152 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01466967 0,07531303 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01466967 0,0751453 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01466967 0,07497831 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01466967 0,07481206 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01466967 0,07464655 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01466967 0,07448176 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01466967 0,07431771 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01466967 0,07415437 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01466967 0,07399175 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01466967 0,07382984 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01466967 0,07366864 ! prostate gland development GO:0030850 9 6 0,000 0,01466967 0,07350815 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01466967 0,07334835 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01466967 0,07318924 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01466967 0,07303082 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01466967 0,07287309 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01466967 0,07271603 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01466967 0,07255965 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01466967 0,07240395 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01466967 0,07224891 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01466967 0,07209453 ! neuron adhesion GO:0007158 9 6 0,000 0,01466967 0,07194081 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01466967 0,07178774 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01466967 0,07163533 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01466967 0,07148356 ! signal peptide processing GO:0006465 8 6 0,000 0,01466967 0,07133243 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01466967 0,07118194 ! mRNA stabilization GO:0048255 15 6 0,000 0,01466967 0,07103208 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01466967 0,07088286 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01466967 0,07073425 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01466967 0,07058627 ! opsonization GO:0008228 8 6 0,000 0,01466967 0,07043891 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01466967 0,07029216 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01466967 0,07014603 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01466967 0,0700005 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01466967 0,06985557 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01466967 0,06971124 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01466967 0,0695675 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01466967 0,06942436 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01466967 0,0692818 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01466967 0,06913983 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01466967 0,06899844 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01466967 0,06885763 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01466967 0,06871739 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01466967 0,06857772 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01466967 0,06843862 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01466967 0,06830008 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01466967 0,0681621 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01466967 0,06802468 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01466967 0,0678878 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01466967 0,06775148 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01466967 0,06761571 ! thymic T cell selection GO:0045061 12 6 0,000 0,01466967 0,06748048 ! protein lipoylation GO:0009249 10 6 0,000 0,01466967 0,06734579 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01466967 0,06721163 ! pigment granule organization GO:0048753 11 6 0,000 0,01466967 0,06707801 ! drug transport GO:0015893 6 6 0,000 0,01466967 0,06694492 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01466967 0,06681235 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01466967 0,06668031 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01466967 0,06654879 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01466967 0,06641779 ! histidine metabolic process GO:0006547 6 6 0,000 0,01466967 0,06628731 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01466967 0,06615733 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01466967 0,06602786 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 0,01466967 0,0658989 ! adenohypophysis development GO:0021984 10 6 0,000 0,01466967 0,06577045 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01466967 0,06564249 ! hyperosmotic response GO:0006972 8 6 0,000 0,01466967 0,06551503 ! microtubule nucleation GO:0007020 10 6 0,000 0,01466967 0,06538806 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01466967 0,06526158 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01466967 0,0651356 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01466967 0,06501009 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01466967 0,06488507 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01466967 0,06476054 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01466967 0,06463647 ! response to dietary excess GO:0002021 7 6 0,000 0,01466967 0,06451289 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01466967 0,06438977 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01466967 0,06426712 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01466967 0,06414494 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01466967 0,06402322 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01466967 0,06390197 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01466967 0,06378117 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01466967 0,06366083 ! neuron apoptosis GO:0051402 8 6 0,000 0,01466967 0,06354094 ! organic alcohol transport GO:0015850 9 6 0,000 0,01466967 0,0634215 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01466967 0,06330251 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01466967 0,06318397 ! carnitine transport GO:0015879 8 6 0,000 0,01466967 0,06306587 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01466967 0,06294821 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01466967 0,06283099 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01466967 0,0627142 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01466967 0,06259785 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01466967 0,06248192 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01466967 0,06236643 ! parturition GO:0007567 12 6 0,000 0,01466967 0,06225136 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01466967 0,06213672 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01466967 0,0620225 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01466967 0,0619087 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01466967 0,06179531 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01466967 0,06168234 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01466967 0,06156978 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01466967 0,06145763 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01466967 0,06134589 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01466967 0,06123455 ! macrophage differentiation GO:0030225 10 6 0,000 0,01466967 0,06112362 ! astrocyte development GO:0014002 14 6 0,000 0,01466967 0,06101309 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01466967 0,06090296 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01466967 0,06079322 ! interaction with symbiont GO:0051702 8 6 0,000 0,01466967 0,06068388 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01466967 0,06057494 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01466967 0,06046638 ! eating behavior GO:0042755 6 6 0,000 0,01466967 0,06035821 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01466967 0,06025043 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01466967 0,06014303 ! response to copper ion GO:0046688 9 6 0,000 0,01466967 0,06003601 ! DNA topological change GO:0006265 8 6 0,000 0,01466967 0,05992938 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01466967 0,05982312 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01466967 0,05971724 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01466967 0,05961173 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01466967 0,05950659 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01466967 0,05940183 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01466967 0,05929743 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01466967 0,0591934 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01466967 0,05908974 ! hair follicle maturation GO:0048820 7 6 0,000 0,01466967 0,05898643 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01466967 0,05888349 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01466967 0,0587809 ! Schwann cell development GO:0014044 14 6 0,000 0,01466967 0,05867868 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01466967 0,0585768 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01466967 0,05847528 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01466967 0,05837412 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01466967 0,0582733 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01466967 0,05817283 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01466967 0,0580727 ! histone ubiquitination GO:0016574 7 6 0,000 0,01466967 0,05797292 ! regulation of meiosis GO:0040020 10 6 0,000 0,01466967 0,05787348 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01466967 0,05777438 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01466967 0,05767562 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01466967 0,0575772 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01466967 0,05747911 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01466967 0,05738136 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01466967 0,05728394 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01466967 0,05718685 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01466967 0,05709008 ! receptor internalization GO:0031623 9 6 0,000 0,01466967 0,05699365 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01466967 0,05689754 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01466967 0,05680175 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01466967 0,05670628 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01466967 0,05661114 ! protein deubiquitination GO:0016579 8 6 0,000 0,01466967 0,05651631 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01466967 0,0564218 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01466967 0,05632761 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01466967 0,05623373 ! axonal fasciculation GO:0007413 9 6 0,000 0,01466967 0,05614016 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01466967 0,05604691 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01466967 0,05595396 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01466967 0,05586132 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01466967 0,05576899 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01466967 0,05567696 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01466967 0,05558524 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01466967 0,05549381 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01466967 0,05540269 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01466967 0,05531187 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01466967 0,05522134 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01466967 0,05513111 ! adult feeding behavior GO:0008343 6 6 0,000 0,01466967 0,05504117 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01466967 0,05495153 ! blastocyst growth GO:0001832 15 6 0,000 0,01466967 0,05486218 ! pigment granule transport GO:0051904 12 6 0,000 0,01466967 0,05477312 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01466967 0,05468434 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01466967 0,05459586 ! catecholamine transport GO:0051937 7 6 0,000 0,01466967 0,05450766 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01466967 0,05441974 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01466967 0,05433211 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01466967 0,05424476 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01466967 0,05415769 ! protein prenylation GO:0018342 10 6 0,000 0,01466967 0,0540709 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01466967 0,05398438 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01466967 0,05389815 ! gland development GO:0048732 148 77 1,000 0,01538704 0,0564437 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01709409 0,06260575 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01709409 0,06250622 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01709409 0,062407 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01709409 0,0623081 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01709409 0,06220951 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01709409 0,06211123 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01709409 0,06201327 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01709409 0,06191561 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01709409 0,06181826 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01709409 0,06172121 ! reproductive behavior GO:0019098 12 7 0,000 0,01709409 0,06162447 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01709409 0,06152803 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,01709409 0,06143189 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01709409 0,06133605 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,01709409 0,06124051 ! oligopeptide transport GO:0006857 11 7 0,000 0,01709409 0,06114527 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01709409 0,06105033 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01709409 0,06095567 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,01709409 0,06086132 ! pericardium development GO:0060039 8 7 0,000 0,01709409 0,06076725 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01709409 0,06067347 ! fibril organization GO:0043206 13 7 0,000 0,01709409 0,06057999 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01709409 0,06048679 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01709409 0,06039387 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01709409 0,06030124 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01709409 0,0602089 ! lipoprotein transport GO:0042953 9 7 0,000 0,01709409 0,06011684 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01709409 0,06002505 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01709409 0,05993355 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01709409 0,05984233 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01709409 0,05975138 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01709409 0,05966071 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01709409 0,05957032 ! chemosensory behavior GO:0007635 9 7 0,000 0,01709409 0,0594802 ! microtubule bundle formation GO:0001578 8 7 0,000 0,01709409 0,05939035 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,01709409 0,05930077 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01709409 0,05921146 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01709409 0,05912242 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01709409 0,05903365 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01709409 0,05894514 ! reflex GO:0060004 12 7 0,000 0,01709409 0,0588569 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01709409 0,05876892 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01709409 0,05868121 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01709409 0,05859376 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01709409 0,05850656 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01709409 0,05841963 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01709409 0,05833295 ! spinal cord patterning GO:0021511 7 7 0,000 0,01709409 0,05824653 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01709409 0,05816037 ! adrenal gland development GO:0030325 17 7 0,000 0,01709409 0,05807446 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01709409 0,05798881 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01709409 0,0579034 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01709409 0,05781825 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01709409 0,05773335 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01709409 0,0576487 ! endosome organization GO:0007032 10 7 0,000 0,01709409 0,05756429 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01709409 0,05748013 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,01709409 0,05739622 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01709409 0,05731255 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01709409 0,05722913 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01709409 0,05714595 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01709409 0,057063 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01709409 0,0569803 ! galactose metabolic process GO:0006012 10 7 0,000 0,01709409 0,05689784 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01709409 0,05681562 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01709409 0,05673364 ! organ growth GO:0035265 11 7 0,000 0,01709409 0,05665189 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,01709409 0,05657037 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01709409 0,0564891 ! retinol metabolic process GO:0042572 9 7 0,000 0,01709409 0,05640805 ! behavioral fear response GO:0001662 13 7 0,000 0,01709409 0,05632724 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,01709409 0,05624665 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01709409 0,0561663 ! rRNA modification GO:0000154 12 7 0,000 0,01709409 0,05608618 ! protein heterooligomerization GO:0051291 10 7 0,000 0,01709409 0,05600628 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01709409 0,05592661 ! response to UV-B GO:0010224 11 7 0,000 0,01709409 0,05584717 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01709409 0,05576796 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,01709409 0,05568897 ! intermediate filament organization GO:0045109 11 7 0,000 0,01709409 0,0556102 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,01709409 0,05553165 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01709409 0,05545333 ! fibrinolysis GO:0042730 9 7 0,000 0,01709409 0,05537523 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01709409 0,05529734 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01709409 0,05521968 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01709409 0,05514223 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01709409 0,055065 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01709409 0,05498799 ! response to tropane GO:0014073 13 7 0,000 0,01709409 0,05491119 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01709409 0,0548346 ! melanosome localization GO:0032400 10 7 0,000 0,01709409 0,05475823 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01709409 0,05468207 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01709409 0,05460613 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01709409 0,05453039 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01709409 0,05445486 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01709409 0,05437954 ! mast cell activation GO:0045576 9 7 0,000 0,01709409 0,05430443 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01709409 0,05422953 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,01709409 0,05415484 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01709409 0,05408034 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01709409 0,05400606 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01709409 0,05393198 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01709409 0,0538581 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,01709409 0,05378442 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01709409 0,05371094 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01709409 0,05363767 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,01709409 0,05356459 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01709409 0,05349171 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01709409 0,05341904 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01709409 0,05334655 ! response to tumor cell GO:0002347 12 7 0,000 0,01709409 0,05327427 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01709409 0,05320218 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01709409 0,05313028 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01709409 0,05305858 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,01709409 0,05298708 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01709409 0,05291576 ! diuresis GO:0030146 12 7 0,000 0,01709409 0,05284464 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01709409 0,05277371 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01709409 0,05270296 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01709409 0,05263241 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01709409 0,05256205 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01709409 0,05249187 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01709409 0,05242188 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01709409 0,05235208 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01709409 0,05228246 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01709409 0,05221303 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01709409 0,05214378 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01709409 0,05207472 ! lymph node development GO:0048535 9 7 0,000 0,01709409 0,05200583 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01709409 0,05193713 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01709409 0,05186862 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01709409 0,05180028 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,01709409 0,05173212 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,01709409 0,05166414 ! ATP catabolic process GO:0006200 10 7 0,000 0,01709409 0,05159634 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01709409 0,05152872 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01709409 0,05146127 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,01709409 0,051394 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01709409 0,05132691 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01709409 0,05125999 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01709409 0,05119324 ! muscle adaptation GO:0043500 12 7 0,000 0,01709409 0,05112667 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01709409 0,05106027 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01709409 0,05099405 ! retina homeostasis GO:0001895 9 7 0,000 0,01709409 0,05092799 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01709409 0,05086211 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,01709409 0,0507964 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01709409 0,05073085 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,01709409 0,05066548 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01709409 0,05060027 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01709409 0,05053523 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01709409 0,05047036 ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,01854295 0,05467794 ! regulation of membrane potential GO:0042391 128 85 1,000 0,01854295 0,05460793 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,01895515 0,05575045 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,01937122 0,05690141 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,01937122 0,05682883 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,01951269 0,05717093 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,01951269 0,05709819 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,01951269 0,05702564 ! axon extension GO:0048675 11 8 0,000 0,01951269 0,05695327 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,01951269 0,05688109 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,01951269 0,05680909 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,01951269 0,05673727 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,01951269 0,05666563 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,01951269 0,05659417 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,01951269 0,0565229 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,01951269 0,0564518 ! phosphate transport GO:0006817 10 8 0,000 0,01951269 0,05638088 ! N-glycan processing GO:0006491 12 8 0,000 0,01951269 0,05631014 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,01951269 0,05623957 ! UTP metabolic process GO:0046051 8 8 0,000 0,01951269 0,05616919 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,01951269 0,05609897 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,01951269 0,05602894 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,01951269 0,05595908 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,01951269 0,05588939 ! succinate metabolic process GO:0006105 14 8 0,000 0,01951269 0,05581988 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,01951269 0,05575053 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,01951269 0,05568136 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,01951269 0,05561237 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,01951269 0,05554354 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,01951269 0,05547488 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,01951269 0,05540639 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,01951269 0,05533808 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01951269 0,05526993 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,01951269 0,05520194 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,01951269 0,05513413 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,01951269 0,05506648 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,01951269 0,05499899 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,01951269 0,05493168 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,01951269 0,05486452 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,01951269 0,05479753 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,01951269 0,05473071 ! astrocyte differentiation GO:0048708 16 8 0,000 0,01951269 0,05466404 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,01951269 0,05459754 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,01951269 0,0545312 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,01951269 0,05446502 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,01951269 0,05439901 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,01951269 0,05433315 ! melanin metabolic process GO:0006582 12 8 0,000 0,01951269 0,05426745 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,01951269 0,05420191 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,01951269 0,05413653 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,01951269 0,0540713 ! macrophage activation GO:0042116 12 8 0,000 0,01951269 0,05400623 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,01951269 0,05394132 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,01951269 0,05387657 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,01951269 0,05381197 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,01951269 0,05374752 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01951269 0,05368323 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,01951269 0,05361909 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,01951269 0,05355511 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,01951269 0,05349127 ! ruffle organization GO:0031529 11 8 0,000 0,01951269 0,05342759 ! osteoblast development GO:0002076 13 8 0,000 0,01951269 0,05336407 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,01951269 0,05330069 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,01951269 0,05323746 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,01951269 0,05317438 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,01951269 0,05311146 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,01951269 0,05304868 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,01951269 0,05298604 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,01951269 0,05292356 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,01951269 0,05286122 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,01951269 0,05279903 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,01951269 0,05273699 ! oligodendrocyte development GO:0014003 8 8 0,000 0,01951269 0,05267509 ! segment specification GO:0007379 10 8 0,000 0,01951269 0,05261334 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,01951269 0,05255173 ! cellular extravasation GO:0045123 11 8 0,000 0,01951269 0,05249027 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,01951269 0,05242895 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,01951269 0,05236777 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,01951269 0,05230674 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,01951269 0,05224584 ! snRNA metabolic process GO:0016073 10 8 0,000 0,01951269 0,05218509 GO:0016180|snRNA processing, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 0,000 0,01951269 0,05212448 ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,01951269 0,05206401 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,01951269 0,05200368 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,01951269 0,05194349 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,01951269 0,05188344 ! nucleosome disassembly GO:0006337 12 8 0,000 0,01951269 0,05182353 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,01951269 0,05176376 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,01951269 0,05170412 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,01951269 0,05164463 ! icosanoid secretion GO:0032309 12 8 0,000 0,01951269 0,05158526 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,01951269 0,05152604 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,01951269 0,05146695 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,01951269 0,051408 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,01951269 0,05134918 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,01951269 0,05129049 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,01951269 0,05123194 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,01951269 0,05117352 ! sterol catabolic process GO:0016127 9 8 0,000 0,01951269 0,05111524 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,01951269 0,05105709 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,01951269 0,05099907 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,01951269 0,05094118 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,01951269 0,05088342 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,01951269 0,0508258 ! prophase GO:0051324 11 8 0,000 0,01951269 0,0507683 ! S phase GO:0051320 8 8 0,000 0,01951269 0,05071094 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,01951269 0,0506537 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,01951269 0,05059659 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,01951269 0,05053962 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,01951269 0,05048277 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,01951269 0,05042604 ! hormone catabolic process GO:0042447 13 8 0,000 0,01951269 0,05036945 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,01951269 0,05031298 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,01951269 0,05025664 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,01951269 0,05020042 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,01951269 0,05014433 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,01951269 0,05008837 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,01951269 0,05003253 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,01951269 0,04997681 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,01951269 0,04992122 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,01951269 0,04986576 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,01951269 0,04981041 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,01951269 0,04975519 ! lamellipodium assembly GO:0030032 9 8 0,000 0,01951269 0,04970009 ! regulation of embryonic development GO:0045995 16 8 0,000 0,01951269 0,04964511 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,01951269 0,04959025 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,01951269 0,04953552 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,01979113 0,05018699 ! interphase GO:0051325 159 88 1,000 0,01979113 0,05013172 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,02021487 0,05114873 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,02192547 0,05541602 ! regulation of developmental growth GO:0048638 13 9 0,000 0,02192547 0,05535519 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,02192547 0,05529449 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02192547 0,05523393 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02192547 0,0551735 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02192547 0,0551132 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,02192547 0,05505303 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02192547 0,054993 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02192547 0,05493309 ! GTP metabolic process GO:0046039 9 9 0,000 0,02192547 0,05487332 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02192547 0,05481367 ! social behavior GO:0035176 14 9 0,000 0,02192547 0,05475416 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02192547 0,05469477 ! artery development GO:0060840 19 9 0,000 0,02192547 0,05463551 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02192547 0,05457638 ! regulation of glycolysis GO:0006110 15 9 0,000 0,02192547 0,05451738 ! response to pain GO:0048265 16 9 0,000 0,02192547 0,05445851 ! protein complex disassembly GO:0043241 17 9 0,000 0,02192547 0,05439976 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02192547 0,05434114 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02192547 0,05428265 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02192547 0,05422428 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02192547 0,05416603 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02192547 0,05410792 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02192547 0,05404992 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02192547 0,05399205 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02192547 0,05393431 ! protein targeting to ER GO:0045047 19 9 0,000 0,02192547 0,05387669 ! T cell selection GO:0045058 18 9 0,000 0,02192547 0,05381919 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02192547 0,05376181 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02192547 0,05370456 ! arginine catabolic process GO:0006527 10 9 0,000 0,02192547 0,05364742 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02192547 0,05359041 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02192547 0,05353352 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02192547 0,05347675 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02192547 0,0534201 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02192547 0,05336358 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02192547 0,05330717 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02192547 0,05325087 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02192547 0,0531947 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02192547 0,05313865 ! mannose metabolic process GO:0006013 9 9 0,000 0,02192547 0,05308271 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02192547 0,0530269 ! receptor clustering GO:0043113 15 9 0,000 0,02192547 0,0529712 ! epithelial cell development GO:0002064 10 9 0,000 0,02192547 0,05291561 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02192547 0,05286015 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02192547 0,05280479 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02192547 0,05274956 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02192547 0,05269444 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02192547 0,05263943 ! motor axon guidance GO:0008045 14 9 0,000 0,02192547 0,05258454 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02192547 0,05252977 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02192547 0,05247511 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02192547 0,05242056 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02192547 0,05236613 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02192547 0,0523118 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02192547 0,05225759 ! DNA ligation GO:0006266 14 9 0,000 0,02192547 0,0522035 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02192547 0,05214951 ! response to amine stimulus GO:0014075 13 9 0,000 0,02192547 0,05209564 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02192547 0,05204188 ! erythrocyte development GO:0048821 11 9 0,000 0,02192547 0,05198823 ! renal water homeostasis GO:0003091 14 9 0,000 0,02192547 0,05193468 ! postreplication repair GO:0006301 11 9 0,000 0,02192547 0,05188125 ! mRNA cleavage GO:0006379 13 9 0,000 0,02192547 0,05182793 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02192547 0,05177472 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02192547 0,05172162 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02192547 0,05166863 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02192547 0,05161574 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02192547 0,05156296 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02192547 0,05151029 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02192547 0,05145773 ! acid secretion GO:0046717 14 9 0,000 0,02192547 0,05140528 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02192547 0,05135293 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02192547 0,05130069 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02192547 0,05124856 ! purine base metabolic process GO:0006144 18 9 0,000 0,02192547 0,05119653 ! oocyte differentiation GO:0009994 12 9 0,000 0,02192547 0,0511446 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02192547 0,05109278 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02192547 0,05104107 ! spleen development GO:0048536 15 9 0,000 0,02192547 0,05098946 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02192547 0,05093796 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02192547 0,05088656 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02192547 0,05083526 ! detection of calcium ion GO:0005513 13 9 0,000 0,02192547 0,05078407 ! blastocyst formation GO:0001825 12 9 0,000 0,02192547 0,05073298 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02192547 0,05068199 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02192547 0,0506311 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02192547 0,05058032 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02192547 0,05052964 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02192547 0,05047906 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02192547 0,05042858 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02192547 0,0503782 ! prepulse inhibition GO:0060134 14 9 0,000 0,02192547 0,05032792 ! embryonic placenta development GO:0001892 12 9 0,000 0,02192547 0,05027775 ! insulin secretion GO:0030073 17 9 0,000 0,02192547 0,05022767 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02192547 0,05017769 ! response to nicotine GO:0035094 16 9 0,000 0,02192547 0,05012781 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02192547 0,05007803 ! nucleus localization GO:0051647 15 9 0,000 0,02192547 0,05002835 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02192547 0,04997877 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,02194766 0,04997983 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,02194766 0,04993039 ! angiogenesis GO:0001525 149 95 1,000 0,02283649 0,05190111 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,02328643 0,05287147 ! response to light stimulus GO:0009416 153 96 1,000 0,02328643 0,05281933 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02433245 0,05513757 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02433245 0,05508331 ! neuron fate specification GO:0048665 11 10 0,000 0,02433245 0,05502914 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02433245 0,05497509 ! thyroid gland development GO:0030878 19 10 0,000 0,02433245 0,05492114 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,02433245 0,05486729 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02433245 0,05481355 ! synapsis GO:0007129 13 10 0,000 0,02433245 0,05475992 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02433245 0,05470639 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02433245 0,05465297 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02433245 0,05459965 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02433245 0,05454643 ! sulfate transport GO:0008272 12 10 0,000 0,02433245 0,05449332 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02433245 0,05444031 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02433245 0,0543874 ! androgen metabolic process GO:0008209 13 10 0,000 0,02433245 0,0543346 ! phospholipid efflux GO:0033700 16 10 0,000 0,02433245 0,0542819 ! hippocampus development GO:0021766 19 10 0,000 0,02433245 0,0542293 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02433245 0,0541768 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02433245 0,05412441 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02433245 0,05407211 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02433245 0,05401992 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02433245 0,05396783 ! pathogenesis GO:0009405 13 10 0,000 0,02433245 0,05391584 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02433245 0,05386394 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02433245 0,05381215 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02433245 0,05376046 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02433245 0,05370887 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02433245 0,05365737 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02433245 0,05360598 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02433245 0,05355468 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02433245 0,05350348 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02433245 0,05345238 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02433245 0,05340137 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02433245 0,05335047 ! response to X-ray GO:0010165 16 10 0,000 0,02433245 0,05329966 ! B cell proliferation GO:0042100 14 10 0,000 0,02433245 0,05324894 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02433245 0,05319833 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02433245 0,0531478 ! forebrain cell migration GO:0021885 17 10 0,000 0,02433245 0,05309738 ! lipid digestion GO:0044241 15 10 0,000 0,02433245 0,05304705 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02433245 0,05299682 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02433245 0,05294668 ! UV protection GO:0009650 14 10 0,000 0,02433245 0,05289663 ! entry into host cell GO:0030260 20 10 0,000 0,02433245 0,05284668 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02433245 0,05279683 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02433245 0,05274707 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02433245 0,0526974 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02433245 0,05264783 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02433245 0,05259834 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02433245 0,05254896 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02433245 0,05249966 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02433245 0,05245046 ! regulation of organ growth GO:0046620 11 10 0,000 0,02433245 0,05240135 ! response to dsRNA GO:0043331 18 10 0,000 0,02433245 0,05235233 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02433245 0,0523034 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02433245 0,05225456 ! embryonic axis specification GO:0000578 12 10 0,000 0,02433245 0,05220582 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02433245 0,05215717 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02433245 0,0521086 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02433245 0,05206013 ! cranial nerve development GO:0021545 12 10 0,000 0,02433245 0,05201175 ! fucose catabolic process GO:0019317 16 10 0,000 0,02433245 0,05196345 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02433245 0,05191525 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02433245 0,05186713 ! protein sumoylation GO:0016925 12 10 0,000 0,02433245 0,05181911 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02433245 0,05177117 ! zymogen activation GO:0031638 14 10 0,000 0,02433245 0,05172333 ! salivary gland development GO:0007431 22 10 0,000 0,02433245 0,05167557 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02433245 0,05162789 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02433245 0,05158031 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02433245 0,05153282 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02433245 0,05148541 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02433245 0,05143809 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02433245 0,05139085 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02433245 0,0513437 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02433245 0,05129664 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02433245 0,05124967 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,02433245 0,05120278 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02433245 0,05115598 ! activation of innate immune response GO:0002218 10 10 0,000 0,02433245 0,05110926 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02433245 0,05106263 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02433245 0,05101608 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02433245 0,05096962 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02433245 0,05092324 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02433245 0,05087694 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,02433245 0,05083073 ! calcium ion transport GO:0006816 167 99 1,000 0,02465818 0,05146444 ! extracellular structure organization GO:0043062 156 99 1,000 0,02465818 0,05141779 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,02465818 0,05137121 ! divalent metal ion transport GO:0070838 171 100 1,000 0,02512267 0,05229152 ! rRNA transcription GO:0009303 17 11 0,000 0,02673365 0,05559439 ! respiratory burst GO:0045730 14 11 0,000 0,02673365 0,05554416 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,02673365 0,05549403 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,02673365 0,05544399 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,02673365 0,05539405 ! virus-host interaction GO:0019048 17 11 0,000 0,02673365 0,05534419 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,02673365 0,05529442 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,02673365 0,05524473 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,02673365 0,05519514 ! RNA polyadenylation GO:0043631 19 11 0,000 0,02673365 0,05514564 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,02673365 0,05509623 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,02673365 0,0550469 ! mating GO:0007618 14 11 0,000 0,02673365 0,05499767 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,02673365 0,05494852 ! T cell proliferation GO:0042098 20 11 0,000 0,02673365 0,05489946 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,02673365 0,05485048 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,02673365 0,0548016 ! bone resorption GO:0045453 16 11 0,000 0,02673365 0,0547528 ! regulated secretory pathway GO:0045055 14 11 0,000 0,02673365 0,05470408 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,02673365 0,05465546 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,02673365 0,05460692 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,02673365 0,05455846 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,02673365 0,0545101 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,02673365 0,05446182 ! syncytium formation GO:0006949 15 11 0,000 0,02673365 0,05441362 ! plasma membrane organization GO:0007009 18 11 0,000 0,02673365 0,05436551 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,02673365 0,05431748 ! focal adhesion formation GO:0048041 24 11 0,000 0,02673365 0,05426954 ! mitotic spindle organization GO:0007052 15 11 0,000 0,02673365 0,05422168 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,02673365 0,05417391 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,02673365 0,05412622 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,02673365 0,05407862 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,02673365 0,0540311 ! adult heart development GO:0007512 11 11 0,000 0,02673365 0,05398366 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,02673365 0,05393631 ! temperature homeostasis GO:0001659 16 11 0,000 0,02673365 0,05388904 ! L-glutamate transport GO:0015813 16 11 0,000 0,02673365 0,05384185 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,02673365 0,05379474 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,02673365 0,05374772 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,02673365 0,05370078 ! protein homotetramerization GO:0051289 18 11 0,000 0,02673365 0,05365392 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,02673365 0,05360714 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,02673365 0,05356044 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,02673365 0,05351383 ! vasoconstriction GO:0042310 15 11 0,000 0,02673365 0,0534673 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,02673365 0,05342084 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,02673365 0,05337447 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,02673365 0,05332818 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,02673365 0,05328197 ! ribosome assembly GO:0042255 13 11 0,000 0,02673365 0,05323584 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,02673365 0,05318978 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,02673365 0,05314381 ! chromatin silencing GO:0006342 19 11 0,000 0,02673365 0,05309792 ! nucleosome positioning GO:0016584 13 11 0,000 0,02673365 0,05305211 ! T cell homeostasis GO:0043029 20 11 0,000 0,02673365 0,05300637 ! regulation of isotype switching GO:0045191 19 11 0,000 0,02673365 0,05296071 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,02673365 0,05291514 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,02673365 0,05286964 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,02673365 0,05282422 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,02673365 0,05277888 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,02673365 0,05273361 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,02673365 0,05268842 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,02673365 0,05264331 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,02673365 0,05259828 ! male genitalia development GO:0030539 13 11 0,000 0,02673365 0,05255332 ! cholesterol efflux GO:0033344 19 11 0,000 0,02673365 0,05250845 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,02673365 0,05246364 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,02673365 0,05241892 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,02673365 0,05237427 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,02673365 0,05232969 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,02673365 0,0522852 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,02673365 0,05224077 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,02673365 0,05219643 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,02673365 0,05215215 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,02673365 0,05210796 ! lysogeny GO:0030069 18 11 0,000 0,02673365 0,05206384 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,02673365 0,05201979 ! acrosome reaction GO:0007340 13 11 0,000 0,02673365 0,05197582 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,02673365 0,05193192 ! lactation GO:0007595 20 12 0,000 0,02912907 0,05653744 ! reproductive cellular process GO:0048610 14 12 0,000 0,02912907 0,05648977 ! tRNA modification GO:0006400 14 12 0,000 0,02912907 0,05644218 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,02912907 0,05639467 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,02912907 0,05634724 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,02912907 0,05629989 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,02912907 0,05625262 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,02912907 0,05620542 ! non-recombinational repair GO:0000726 19 12 0,000 0,02912907 0,05615831 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,02912907 0,05611128 ! peroxisomal transport GO:0043574 21 12 0,000 0,02912907 0,05606432 ! cartilage condensation GO:0001502 18 12 0,000 0,02912907 0,05601745 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,02912907 0,05597065 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,02912907 0,05592393 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,02912907 0,05587729 ! heart looping GO:0001947 15 12 0,000 0,02912907 0,05583072 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,02912907 0,05578423 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,02912907 0,05573782 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,02912907 0,05569149 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,02912907 0,05564524 ! arginine metabolic process GO:0006525 13 12 0,000 0,02912907 0,05559906 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,02912907 0,05555296 ! methionine metabolic process GO:0006555 13 12 0,000 0,02912907 0,05550693 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,02912907 0,05546098 ! Golgi organization GO:0007030 18 12 0,000 0,02912907 0,05541511 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,02912907 0,05536931 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,02912907 0,05532359 ! monoamine transport GO:0015844 13 12 0,000 0,02912907 0,05527794 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02912907 0,05523237 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,02912907 0,05518687 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,02912907 0,05514145 ! L-amino acid transport GO:0015807 20 12 0,000 0,02912907 0,05509611 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,02912907 0,05505083 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,02912907 0,05500564 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,02912907 0,05496051 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,02912907 0,05491546 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,02912907 0,05487049 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,02912907 0,05482559 ! cerebellum development GO:0021549 13 12 0,000 0,02912907 0,05478076 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,02912907 0,054736 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,02912907 0,05469132 ! histone acetylation GO:0016573 23 12 0,000 0,02912907 0,05464671 ! histone methylation GO:0016571 15 12 0,000 0,02912907 0,05460217 ! autonomic nervous system development GO:0048483 23 12 0,000 0,02912907 0,05455771 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,02912907 0,05451332 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,02912907 0,054469 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,02912907 0,05442475 ! response to gamma radiation GO:0010332 20 12 0,000 0,02912907 0,05438057 ! regulation of epidermis development GO:0045682 17 12 0,000 0,02912907 0,05433647 ! intestinal absorption GO:0050892 19 12 0,000 0,02912907 0,05429244 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,02912907 0,05424847 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,02912907 0,05420458 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,02912907 0,05416076 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,02912907 0,05411702 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,02912907 0,05407334 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,02912907 0,05402973 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,02912907 0,05398619 ! microspike assembly GO:0030035 23 12 0,000 0,02912907 0,05394273 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,02912907 0,05389933 ! response to cold GO:0009409 14 12 0,000 0,02912907 0,053856 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,03151874 0,05822739 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,03151874 0,05818065 ! cGMP metabolic process GO:0046068 16 13 0,000 0,03151874 0,058134 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,03151874 0,05808742 ! water transport GO:0006833 17 13 0,000 0,03151874 0,05804091 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,03151874 0,05799448 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,03151874 0,05794812 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,03151874 0,05790183 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,03151874 0,05785562 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,03151874 0,05780949 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,03151874 0,05776342 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,03151874 0,05771743 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,03151874 0,05767152 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,03151874 0,05762567 ! response to hexose stimulus GO:0009746 19 13 0,000 0,03151874 0,0575799 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,03151874 0,0575342 ! glutamate metabolic process GO:0006536 18 13 0,000 0,03151874 0,05748858 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,03151874 0,05744302 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,03151874 0,05739754 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,03151874 0,05735213 ! NAD metabolic process GO:0019674 21 13 0,000 0,03151874 0,05730679 ! exocrine system development GO:0035272 27 13 0,000 0,03151874 0,05726153 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,03151874 0,05721633 ! bone mineralization GO:0030282 15 13 0,000 0,03151874 0,05717121 ! regulation of exocytosis GO:0017157 17 13 0,000 0,03151874 0,05712616 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,03151874 0,05708118 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,03151874 0,05703627 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,03151874 0,05699143 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,03151874 0,05694666 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,03151874 0,05690196 ! genitalia development GO:0048806 15 13 0,000 0,03151874 0,05685733 ! regulation of cellular pH GO:0030641 20 13 0,000 0,03151874 0,05681277 ! cellular pigmentation GO:0033059 24 13 0,000 0,03151874 0,05676828 ! tissue regeneration GO:0042246 21 13 0,000 0,03151874 0,05672386 ! cofactor transport GO:0051181 19 13 0,000 0,03151874 0,05667951 ! NADP metabolic process GO:0006739 18 13 0,000 0,03151874 0,05663523 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,03151874 0,05659102 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,03151874 0,05654688 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03151874 0,0565028 ! gas transport GO:0015669 18 13 0,000 0,03151874 0,0564588 ! regulation of RNA stability GO:0043487 28 13 0,000 0,03151874 0,05641486 ! heme biosynthetic process GO:0006783 20 13 0,000 0,03151874 0,05637099 ! regulation of axon extension GO:0030516 23 13 0,000 0,03151874 0,05632719 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,03151874 0,05628346 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,03151874 0,05623979 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,03151874 0,0561962 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,03151874 0,05615267 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,03151874 0,05610921 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,03151874 0,05606581 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,03390266 0,06025975 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,03390266 0,06021321 ! superoxide anion generation GO:0042554 18 14 0,000 0,03390266 0,06016675 ! neuron maturation GO:0042551 21 14 0,000 0,03390266 0,06012036 ! regulation of S phase GO:0033261 18 14 0,000 0,03390266 0,06007405 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,03390266 0,0600278 ! myotube differentiation GO:0014902 21 14 0,000 0,03390266 0,05998162 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,03390266 0,05993552 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,03390266 0,05988949 ! inositol metabolic process GO:0006020 20 14 0,000 0,03390266 0,05984352 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,03390266 0,05979763 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,03390266 0,05975181 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,03390266 0,05970606 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,03390266 0,05966038 ! gene silencing by RNA GO:0031047 20 14 0,000 0,03390266 0,05961476 ! response to cAMP GO:0051591 19 14 0,000 0,03390266 0,05956922 ! limbic system development GO:0021761 25 14 0,000 0,03390266 0,05952375 ! startle response GO:0001964 21 14 0,000 0,03390266 0,05947835 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,03390266 0,05943301 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,03390266 0,05938775 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,03390266 0,05934255 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,03390266 0,05929742 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,03390266 0,05925236 ! glycine metabolic process GO:0006544 22 14 0,000 0,03390266 0,05920737 ! pituitary gland development GO:0021983 23 14 0,000 0,03390266 0,05916245 ! cellular response to starvation GO:0009267 21 14 0,000 0,03390266 0,0591176 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,03390266 0,05907281 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,03390266 0,05902809 ! regulation of heart rate GO:0002027 23 14 0,000 0,03390266 0,05898344 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,03390266 0,05893886 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,03390266 0,05889434 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,03390266 0,05884989 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,03390266 0,05880551 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,03390266 0,0587612 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,03390266 0,05871695 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,03390266 0,05867277 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,03390266 0,05862865 ! axon cargo transport GO:0008088 27 14 0,000 0,03390266 0,05858461 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,03390266 0,05854062 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,03390266 0,05849671 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,03390266 0,05845286 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03390266 0,05840907 ! mRNA splice site selection GO:0006376 26 14 0,000 0,03390266 0,05836535 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,03390266 0,0583217 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,03390266 0,05827811 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,03390266 0,05823459 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,03390266 0,05819113 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,03390266 0,05814773 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,03390266 0,0581044 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,03390266 0,05806114 ! muscle maintenance GO:0046716 19 14 0,000 0,03390266 0,05801794 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,03390266 0,0579748 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,03390266 0,05793173 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,03390266 0,05788872 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,03390266 0,05784578 ! cell killing GO:0001906 20 14 0,000 0,03390266 0,0578029 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,03390266 0,05776008 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,03390266 0,05771733 ! cilium assembly GO:0042384 20 14 0,000 0,03390266 0,05767464 ! peptide hormone secretion GO:0030072 23 14 0,000 0,03390266 0,05763201 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,03628084 0,0616292 ! positive regulation of cell size GO:0045793 20 15 0,000 0,03628084 0,06158372 ! metencephalon development GO:0022037 19 15 0,000 0,03628084 0,06153831 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,03628084 0,06149296 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,03628084 0,06144768 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,03628084 0,06140246 ! skin development GO:0043588 25 15 0,000 0,03628084 0,06135731 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,03628084 0,06131223 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,03628084 0,06126721 ! lipid phosphorylation GO:0046834 23 15 0,000 0,03628084 0,06122226 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,03628084 0,06117738 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,03628084 0,06113256 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,03628084 0,06108781 ! bile acid metabolic process GO:0008206 22 15 0,000 0,03628084 0,06104312 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,03628084 0,0609985 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,03628084 0,06095394 ! adult walking behavior GO:0007628 25 15 0,000 0,03628084 0,06090945 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,03628084 0,06086502 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,03628084 0,06082066 ! myoblast differentiation GO:0045445 27 15 0,000 0,03628084 0,06077636 ! centrosome cycle GO:0007098 16 15 0,000 0,03628084 0,06073213 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,03628084 0,06068796 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,03628084 0,06064385 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,03628084 0,06059981 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,03628084 0,06055584 ! cerebral cortex development GO:0021987 29 15 0,000 0,03628084 0,06051192 ! response to osmotic stress GO:0006970 22 15 0,000 0,03628084 0,06046807 ! vesicle coating GO:0006901 25 15 0,000 0,03628084 0,06042429 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,03628084 0,06038057 ! DNA integration GO:0015074 22 15 0,000 0,03628084 0,06033691 ! peptide secretion GO:0002790 27 15 0,000 0,03628084 0,06029331 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,03628084 0,06024978 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,03628084 0,06020631 ! neuron recognition GO:0008038 22 15 0,000 0,03628084 0,0601629 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,03628084 0,06011956 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,03628084 0,06007627 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,03628084 0,06003305 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,03628084 0,05998989 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,03628084 0,0599468 ! biomineral formation GO:0031214 18 15 0,000 0,03628084 0,05990376 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,03628084 0,05986079 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,03628084 0,05981788 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,03628084 0,05977503 ! dopamine metabolic process GO:0042417 30 15 0,000 0,03628084 0,05973224 ! organic cation transport GO:0015695 19 15 0,000 0,03628084 0,05968952 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,03628084 0,05964685 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,03628084 0,05960424 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,03628084 0,0595617 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,03628084 0,05951922 ! defense response to virus GO:0051607 27 15 0,000 0,03628084 0,05947679 ! peptide hormone processing GO:0016486 19 15 0,000 0,03628084 0,05943443 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,03628084 0,05939213 ! protein secretion GO:0009306 27 16 0,000 0,03865331 0,06323088 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,03865331 0,06318594 ! hormone secretion GO:0046879 25 16 0,000 0,03865331 0,06314107 ! bone remodeling GO:0046849 24 16 0,000 0,03865331 0,06309625 ! endothelial cell migration GO:0043542 22 16 0,000 0,03865331 0,06305151 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,03865331 0,06300682 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,03865331 0,0629622 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,03865331 0,06291764 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,03865331 0,06287314 ! glial cell development GO:0021782 24 16 0,000 0,03865331 0,06282871 ! patterning of blood vessels GO:0001569 24 16 0,000 0,03865331 0,06278434 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,03865331 0,06274003 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,03865331 0,06269578 ! protein polyubiquitination GO:0000209 26 16 0,000 0,03865331 0,0626516 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,03865331 0,06260748 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,03865331 0,06256342 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,03865331 0,06251943 ! fructose metabolic process GO:0006000 20 16 0,000 0,03865331 0,06247549 ! regulation of protein binding GO:0043393 27 16 0,000 0,03865331 0,06243162 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,03865331 0,06238781 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,03865331 0,06234405 ! protein export from nucleus GO:0006611 24 16 0,000 0,03865331 0,06230037 ! negative regulation of immune response GO:0050777 28 16 0,000 0,03865331 0,06225674 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,03865331 0,06221317 ! DNA replication initiation GO:0006270 25 16 0,000 0,03865331 0,06216967 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,03865331 0,06212622 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,03865331 0,06208284 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,03865331 0,06203951 ! diencephalon development GO:0021536 25 16 0,000 0,03865331 0,06199625 ! oogenesis GO:0048477 23 16 0,000 0,03865331 0,06195305 ! neural crest cell migration GO:0001755 24 16 0,000 0,03865331 0,0619099 ! G1 phase GO:0051318 27 16 0,000 0,03865331 0,06186682 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,03865331 0,0618238 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,03865331 0,06178084 GO:0006626|protein targeting to mitochondrion, ! steroid catabolic process GO:0006706 22 16 0,000 0,03865331 0,06173793 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,03865331 0,06169509 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,03865331 0,0616523 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,03865331 0,06160958 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,03865331 0,06156691 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,03865331 0,06152431 ! sperm-egg recognition GO:0035036 16 16 0,000 0,03865331 0,06148176 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,03865331 0,06143927 ! nerve development GO:0021675 18 16 0,000 0,03865331 0,06139684 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,03865331 0,06135447 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,03865331 0,06131215 ! negative regulation of translation GO:0017148 22 16 0,000 0,03865331 0,0612699 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,04102008 0,06497671 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,04102008 0,06493199 ! negative regulation of defense response GO:0031348 19 17 0,000 0,04102008 0,06488733 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,04102008 0,06484274 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,04102008 0,0647982 ! glycerol metabolic process GO:0006071 20 17 0,000 0,04102008 0,06475373 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,04102008 0,06470931 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,04102008 0,06466496 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,04102008 0,06462067 ! signal complex assembly GO:0007172 29 17 0,000 0,04102008 0,06457644 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,04102008 0,06453227 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,04102008 0,06448816 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,04102008 0,06444411 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,04102008 0,06440012 ! memory GO:0007613 25 17 0,000 0,04102008 0,06435619 ! keratinization GO:0031424 17 17 0,000 0,04102008 0,06431232 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,04102008 0,06426852 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,04102008 0,06422477 ! retinoid metabolic process GO:0001523 22 17 0,000 0,04102008 0,06418108 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,04102008 0,06413744 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,04102008 0,06409387 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,04102008 0,06405036 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,04102008 0,06400691 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,04102008 0,06396351 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,04102008 0,06392018 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,04102008 0,0638769 ! membrane budding GO:0006900 29 17 0,000 0,04102008 0,06383368 ! heme metabolic process GO:0042168 27 17 0,000 0,04102008 0,06379052 ! actin filament bundle formation GO:0051017 26 17 0,000 0,04102008 0,06374742 ! neuromuscular junction development GO:0007528 23 17 0,000 0,04102008 0,06370438 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,04102008 0,06366139 ! body fluid secretion GO:0007589 27 17 0,000 0,04102008 0,06361846 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,04102008 0,06357559 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,04102008 0,06353278 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,04102008 0,06349003 ! sensory perception of pain GO:0019233 23 17 0,000 0,04102008 0,06344733 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,04102008 0,06340469 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,04102008 0,06336211 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,04102008 0,06331958 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,04102008 0,06327712 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,04102008 0,06323471 ! cell-cell junction organization GO:0045216 25 17 0,000 0,04102008 0,06319235 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,04102008 0,06315005 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,04102008 0,06310781 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,04102008 0,06306563 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,04102008 0,0630235 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,04102008 0,06298143 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,04102008 0,06293941 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,04338115 0,06651777 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,04338115 0,06647345 ! positive regulation of translation GO:0045727 28 18 0,000 0,04338115 0,06642919 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,04338115 0,066385 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,04338115 0,06634086 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,04338115 0,06629678 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,04338115 0,06625275 ! cAMP metabolic process GO:0046058 33 18 0,000 0,04338115 0,06620879 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,04338115 0,06616489 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,04338115 0,06612104 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,04338115 0,06607725 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,04338115 0,06603352 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,04338115 0,06598985 ! pancreas development GO:0031016 26 18 0,000 0,04338115 0,06594623 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,04338115 0,06590267 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,04338115 0,06585917 ! glutamine metabolic process GO:0006541 23 18 0,000 0,04338115 0,06581573 ! response to retinoic acid GO:0032526 25 18 0,000 0,04338115 0,06577235 ! pigmentation during development GO:0048066 31 18 0,000 0,04338115 0,06572902 ! central nervous system neuron development GO:0021954 30 18 0,000 0,04338115 0,06568575 ! fucose metabolic process GO:0006004 26 18 0,000 0,04338115 0,06564253 ! response to fungus GO:0009620 19 18 0,000 0,04338115 0,06559937 ! peptide cross-linking GO:0018149 31 18 0,000 0,04338115 0,06555627 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,04338115 0,06551323 ! heart process GO:0003015 27 18 0,000 0,04338115 0,06547024 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,04338115 0,06542731 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,04338115 0,06538444 ! visual learning GO:0008542 35 18 0,000 0,04338115 0,06534162 ! somitogenesis GO:0001756 24 18 0,000 0,04338115 0,06529885 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,04338115 0,06525615 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,04338115 0,0652135 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,04338115 0,0651709 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,04338115 0,06512836 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,04338115 0,06508588 ! vitamin transport GO:0051180 24 18 0,000 0,04338115 0,06504345 ! hormone transport GO:0009914 27 18 0,000 0,04338115 0,06500107 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,04338115 0,06495876 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,04338115 0,06491649 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,04338115 0,06487428 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,04338115 0,06483213 ! cell-cell recognition GO:0009988 20 18 0,000 0,04338115 0,06479003 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,04338115 0,06474799 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,04338115 0,064706 ! regulation of glucose import GO:0046324 21 18 0,000 0,04338115 0,06466406 GO:0010827|regulation of glucose transport, ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,04338115 0,06462218 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,04338115 0,06458035 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,04338115 0,06453858 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,04573655 0,06799874 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,04573655 0,06795482 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,04573655 0,06791095 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,04573655 0,06786713 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,04573655 0,06782338 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,04573655 0,06777967 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,04573655 0,06773603 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,04573655 0,06769244 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,04573655 0,06764891 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,04573655 0,06760543 ! regeneration GO:0031099 32 19 0,000 0,04573655 0,06756201 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,04573655 0,06751865 ! response to alkaloid GO:0043279 32 19 0,000 0,04573655 0,06747534 ! sensory perception of taste GO:0050909 23 19 0,000 0,04573655 0,06743209 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,04573655 0,06738889 ! smooth muscle contraction GO:0006939 36 19 0,000 0,04573655 0,06734575 ! peroxisome organization GO:0007031 29 19 0,000 0,04573655 0,06730266 ! digestive system process GO:0022600 30 19 0,000 0,04573655 0,06725963 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,04573655 0,06721665 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,04573655 0,06717373 ! response to vitamin A GO:0033189 26 19 0,000 0,04573655 0,06713086 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,04573655 0,06708805 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,04573655 0,06704529 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,04573655 0,06700258 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,04573655 0,06695993 ! response to starvation GO:0042594 30 19 0,000 0,04573655 0,06691734 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,04573655 0,0668748 ! plasma membrane fusion GO:0045026 23 19 0,000 0,04573655 0,06683231 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,04573655 0,06678988 ! cytolysis GO:0019835 20 19 0,000 0,04573655 0,0667475 ! renal system process GO:0003014 35 19 0,000 0,04573655 0,06670517 ! vasodilation GO:0042311 33 19 0,000 0,04573655 0,0666629 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,04573655 0,06662068 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,04573655 0,06657852 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,04573655 0,0665364 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,04573655 0,06649435 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,04573655 0,06645234 ! sarcomere organization GO:0045214 23 19 0,000 0,04573655 0,06641039 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,04573655 0,06636849 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,04573655 0,06632664 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,04573655 0,06628485 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,04573655 0,06624311 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,04573655 0,06620142 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,04573655 0,06615978 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,04573655 0,0661182 ! protein stabilization GO:0050821 26 19 0,000 0,04573655 0,06607667 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,04808628 0,06942777 ! iron ion transport GO:0006826 37 20 0,000 0,04808628 0,06938421 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,04808628 0,06934071 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,04808628 0,06929726 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,04808628 0,06925387 ! response to vitamin GO:0033273 29 20 0,000 0,04808628 0,06921053 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,04808628 0,06916725 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,04808628 0,06912402 ! spinal cord development GO:0021510 31 20 0,000 0,04808628 0,06908085 ! response to ethanol GO:0045471 37 20 0,000 0,04808628 0,06903772 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,04808628 0,06899466 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,04808628 0,06895164 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,04808628 0,06890868 ! chromosome condensation GO:0030261 31 20 0,000 0,04808628 0,06886577 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,04808628 0,06882292 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,04808628 0,06878012 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,04808628 0,06873737 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,04808628 0,06869468 ! pallium development GO:0021543 38 20 0,000 0,04808628 0,06865204 ! DNA modification GO:0006304 28 20 0,000 0,04808628 0,06860945 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,04808628 0,06856691 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,04808628 0,06852443 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,04808628 0,068482 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,04808628 0,06843962 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,04808628 0,0683973 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,04808628 0,06835503 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,04808628 0,06831281 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,04808628 0,06827064 ! alditol metabolic process GO:0019400 24 20 0,000 0,04808628 0,06822852 ! actin filament-based movement GO:0030048 34 20 0,000 0,04808628 0,06818646 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,05043035 0,07146631 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,05043035 0,0714223 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,05043035 0,07137835 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,05043035 0,07133445 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,05043035 0,0712906 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,05043035 0,07124681 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,05043035 0,07120308 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,05043035 0,07115939 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,05043035 0,07111577 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,05043035 0,07107219 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,05043035 0,07102867 ! protein amino acid acylation GO:0043543 37 21 0,000 0,05043035 0,0709852 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,05043035 0,07094178 ! phototransduction GO:0007602 25 21 0,000 0,05043035 0,07089842 ! dendrite development GO:0016358 35 21 0,000 0,05043035 0,07085511 ! visual behavior GO:0007632 39 21 0,000 0,05043035 0,07081185 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,05043035 0,07076865 ! ovarian follicle development GO:0001541 30 21 0,000 0,05043035 0,0707255 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,05043035 0,0706824 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,05043035 0,07063935 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,05043035 0,07059636 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,05043035 0,07055341 ! cell aging GO:0007569 32 21 0,000 0,05043035 0,07051052 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,05043035 0,07046769 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,05043035 0,0704249 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,05043035 0,07038217 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,05043035 0,07033949 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,05043035 0,07029686 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,05043035 0,07025428 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,05043035 0,07021175 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,05043035 0,07016928 ! fatty acid transport GO:0015908 30 21 0,000 0,05043035 0,07012685 ! immunoglobulin production GO:0002377 33 21 0,000 0,05043035 0,07008448 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,05043035 0,07004216 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,05043035 0,06999989 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,05043035 0,06995767 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,05043035 0,0699155 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,05043035 0,06987338 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,05043035 0,06983131 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,05043035 0,0697893 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,05043035 0,06974733 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,05043035 0,06970542 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,05043035 0,06966355 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,05043035 0,06962174 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,05043035 0,06957997 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,05043035 0,06953826 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,05276879 0,07271913 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,05276879 0,07267558 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,05276879 0,07263209 ! viral genome replication GO:0019079 29 22 0,000 0,05276879 0,07258865 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,05276879 0,07254526 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,05276879 0,07250193 ! leukocyte adhesion GO:0007159 38 22 0,000 0,05276879 0,07245864 ! molting cycle process GO:0022404 40 22 0,000 0,05276879 0,07241541 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,05276879 0,07237223 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,05276879 0,0723291 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,05276879 0,07228602 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,05276879 0,07224299 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,05276879 0,07220001 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,05276879 0,07215709 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,05276879 0,07211422 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,05276879 0,07207139 ! ureteric bud development GO:0001657 32 22 0,000 0,05276879 0,07202862 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,05276879 0,0719859 ! regulation of behavior GO:0050795 38 22 0,000 0,05276879 0,07194323 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,05276879 0,07190061 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,05276879 0,07185804 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,05276879 0,07181552 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,05276879 0,07177305 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,05276879 0,07173063 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,05276879 0,07168826 ! blastocyst development GO:0001824 37 22 0,000 0,05276879 0,07164594 ! neural tube closure GO:0001843 33 22 0,000 0,05276879 0,07160367 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,05276879 0,07156145 ! protein tetramerization GO:0051262 39 22 0,000 0,05276879 0,07151928 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,05510161 0,07463704 ! neuron fate commitment GO:0048663 32 23 0,000 0,05510161 0,07459311 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,05510161 0,07454923 ! myelination GO:0042552 35 23 0,000 0,05510161 0,07450541 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,05510161 0,07446163 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,05510161 0,07441791 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,05510161 0,07437424 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,05510161 0,07433061 ! vesicle targeting GO:0006903 32 23 0,000 0,05510161 0,07428704 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,05510161 0,07424353 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,05510161 0,07420006 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,05510161 0,07415664 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,05510161 0,07411327 ! interaction with host GO:0051701 37 23 0,000 0,05510161 0,07406996 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,05510161 0,07402669 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,05510161 0,07398348 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,05510161 0,07394031 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,05510161 0,0738972 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,05510161 0,07385414 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,05510161 0,07381112 ! cell fate determination GO:0001709 45 23 0,000 0,05510161 0,07376816 ! pentose metabolic process GO:0019321 31 23 0,000 0,05510161 0,07372525 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,05510161 0,07368238 ! spermatid development GO:0007286 33 23 0,000 0,05510161 0,07363957 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,05510161 0,0735968 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,05510161 0,07355409 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,05510161 0,07351143 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,05510161 0,07346881 ! telomere organization GO:0032200 32 23 0,000 0,05510161 0,07342624 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,05510161 0,07338373 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,05510161 0,07334126 ! regulation of amine transport GO:0051952 38 23 0,000 0,05510161 0,07329884 ! liver development GO:0001889 40 23 0,000 0,05510161 0,07325647 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,05742881 0,07630633 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,05742881 0,07626228 ! initiation of viral infection GO:0019059 42 24 0,000 0,05742881 0,07621827 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,05742881 0,07617432 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,05742881 0,07613041 ! superoxide metabolic process GO:0006801 32 24 0,000 0,05742881 0,07608656 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,05742881 0,07604275 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,05742881 0,075999 ! fat cell differentiation GO:0045444 37 24 0,000 0,05742881 0,0759553 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,05742881 0,07591165 ! sperm motility GO:0030317 27 24 0,000 0,05742881 0,07586804 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,05742881 0,07582449 ! vacuole organization GO:0007033 39 24 0,000 0,05742881 0,07578099 ! receptor metabolic process GO:0043112 37 24 0,000 0,05742881 0,07573754 ! neural crest cell development GO:0014032 39 24 0,000 0,05742881 0,07569413 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,05742881 0,07565078 ! primary neural tube formation GO:0014020 35 24 0,000 0,05742881 0,07560748 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,05742881 0,07556422 ! base-excision repair GO:0006284 31 24 0,000 0,05742881 0,07552102 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,05742881 0,07547787 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,05742881 0,07543476 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,05742881 0,0753917 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,05742881 0,0753487 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,05975041 0,07835003 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,05975041 0,07830539 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,05975041 0,07826079 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,05975041 0,07821625 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 43 25 0,000 0,05975041 0,07817176 ! iron ion homeostasis GO:0055072 39 25 0,000 0,05975041 0,07812732 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,05975041 0,07808293 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,05975041 0,07803859 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,05975041 0,0779943 ! phospholipid transport GO:0015914 35 25 0,000 0,05975041 0,07795006 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,05975041 0,07790587 ! detection of light stimulus GO:0009583 30 25 0,000 0,05975041 0,07786173 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,05975041 0,07781764 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,05975041 0,0777736 ! leukocyte proliferation GO:0070661 39 25 0,000 0,05975041 0,07772961 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,05975041 0,07768567 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,06206643 0,0806513 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,06206643 0,08060576 ! translational initiation GO:0006413 43 26 0,000 0,06206643 0,08056027 ! regulation of pH GO:0006885 36 26 0,000 0,06206643 0,08051483 ! circadian rhythm GO:0007623 42 26 0,000 0,06206643 0,08046944 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,06206643 0,08042411 ! post-embryonic development GO:0009791 42 26 0,000 0,06206643 0,08037883 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,06206643 0,08033359 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,06206643 0,08028841 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,06206643 0,08024328 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,06206643 0,0801982 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,06437688 0,0831369 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,06437688 0,08309025 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,06437688 0,08304365 ! catechol metabolic process GO:0009712 43 27 0,000 0,06437688 0,0829971 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,06437688 0,0829506 ! acute-phase response GO:0006953 42 27 0,000 0,06437688 0,08290415 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,06437688 0,08285776 ! myofibril assembly GO:0030239 36 27 0,000 0,06437688 0,08281142 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,06437688 0,08276513 ! response to ionizing radiation GO:0010212 47 27 0,000 0,06437688 0,08271889 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,06437688 0,08267271 ! natural killer cell activation GO:0030101 35 27 0,000 0,06437688 0,08262657 ! lipid oxidation GO:0034440 38 27 0,000 0,06437688 0,08258049 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,06437688 0,08253446 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,06437688 0,08248848 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,06437688 0,08244255 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,06437688 0,08239667 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,06437688 0,08235085 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,06437688 0,08230507 ! gene silencing GO:0016458 41 27 0,000 0,06437688 0,08225934 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,06668177 0,08515717 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,06668177 0,08510991 ! phenol metabolic process GO:0018958 44 28 0,000 0,06668177 0,08506271 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,06668177 0,08501555 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,06668177 0,08496845 ! cell junction assembly GO:0034329 56 28 0,000 0,06668177 0,08492141 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,06668177 0,08487441 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,06668177 0,08482747 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,06668177 0,08478057 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,06668177 0,08473373 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,06668177 0,08468695 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,06668177 0,08464021 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,06668177 0,08459352 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,06668177 0,08454689 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,06668177 0,08450031 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,06668177 0,08445378 ! ensheathment of neurons GO:0007272 43 28 0,000 0,06668177 0,0844073 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,06668177 0,08436087 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,06668177 0,08431449 ! neural tube formation GO:0001841 41 28 0,000 0,06668177 0,08426816 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,06668177 0,08422189 ! placenta development GO:0001890 37 28 0,000 0,06668177 0,08417566 ! regulation of B cell activation GO:0050864 42 28 0,000 0,06668177 0,08412949 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,06898111 0,08698275 ! regulation of innate immune response GO:0045088 38 29 0,000 0,06898111 0,08693509 ! ovulation cycle process GO:0022602 41 29 0,000 0,06898111 0,08688748 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,06898111 0,08683992 ! protein targeting to membrane GO:0006612 53 29 0,000 0,06898111 0,08679242 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,06898111 0,08674497 ! mismatch repair GO:0006298 34 29 0,000 0,06898111 0,08669756 ! muscle cell development GO:0055001 38 29 0,000 0,06898111 0,08665021 ! telencephalon development GO:0021537 52 29 0,000 0,06898111 0,08660292 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,06898111 0,08655567 ! eye morphogenesis GO:0048592 51 29 0,000 0,06898111 0,08650847 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,06898111 0,08646133 ! tissue homeostasis GO:0001894 42 29 0,000 0,06898111 0,08641424 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,07127491 0,08923914 ! organic anion transport GO:0015711 51 30 0,000 0,07127491 0,08919059 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,07127491 0,08914209 ! spliceosome assembly GO:0000245 49 30 0,000 0,07127491 0,08909364 ! spindle organization GO:0007051 37 30 0,000 0,07127491 0,08904525 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,07127491 0,0889969 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,07127491 0,08894862 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,07127491 0,08890038 ! ceramide metabolic process GO:0006672 43 30 0,000 0,07127491 0,08885219 ! ovulation cycle GO:0042698 43 30 0,000 0,07127491 0,08880406 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,07127491 0,08875598 ! adult locomotory behavior GO:0008344 47 30 0,000 0,07127491 0,08870795 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,07127491 0,08865998 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,07127491 0,08861205 ! response to heat GO:0009408 41 30 0,000 0,07127491 0,08856418 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,07127491 0,08851636 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,07127491 0,08846859 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,0735632 0,09125963 ! negative regulation of secretion GO:0051048 49 31 0,000 0,0735632 0,09121044 ! glial cell differentiation GO:0010001 55 31 0,000 0,0735632 0,09116129 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,0735632 0,0911122 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,0735632 0,09106316 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,0735632 0,09101418 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,0735632 0,09096525 ! segmentation GO:0035282 41 31 0,000 0,0735632 0,09091637 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,0735632 0,09086754 ! metanephros development GO:0001656 58 31 0,000 0,0735632 0,09081876 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,0735632 0,09077004 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,0735632 0,09072137 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,0735632 0,09067275 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,0735632 0,09062419 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,0735632 0,09057567 ! RNA modification GO:0009451 40 31 0,000 0,0735632 0,09052721 ! regulation of muscle development GO:0048634 48 32 0,000 0,07584598 0,0932865 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,07584598 0,09323664 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,07584598 0,09318683 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,07584598 0,09313708 ! meiosis I GO:0007127 52 32 0,000 0,07584598 0,09308738 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,07584598 0,09303773 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,07584598 0,09298814 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,07584598 0,0929386 ! peripheral nervous system development GO:0007422 53 32 0,000 0,07584598 0,09288911 ! regulation of protein stability GO:0031647 48 32 0,000 0,07584598 0,09283968 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,07584598 0,09279029 ! cytokine production GO:0001816 44 32 0,000 0,07584598 0,09274096 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,07584598 0,09269168 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,07584598 0,09264246 ! vesicle localization GO:0051648 47 32 0,000 0,07584598 0,09259329 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,07812326 0,09532281 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,07812326 0,09527227 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,07812326 0,09522178 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,07812326 0,09517135 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,07812326 0,09512097 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,07812326 0,09507064 ! sister chromatid segregation GO:0000819 46 33 0,000 0,07812326 0,09502036 ! actomyosin structure organization GO:0031032 43 33 0,000 0,07812326 0,09497014 ! cell junction organization GO:0034330 63 33 0,000 0,07812326 0,09491997 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,07812326 0,09486985 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,07812326 0,09481979 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,07812326 0,09476978 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,07812326 0,09471982 ! female gonad development GO:0008585 49 33 0,000 0,07812326 0,09466992 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,07812326 0,09462007 ! positive regulation of cell development GO:0010720 54 33 0,000 0,07812326 0,09457027 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,07812326 0,09452052 ! regulation of proteolysis GO:0030162 50 33 0,000 0,07812326 0,09447082 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,07812326 0,09442118 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,07812326 0,09437159 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,07812326 0,09432205 ! cytokinesis GO:0000910 52 33 0,000 0,07812326 0,09427256 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,07812326 0,09422313 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,08039507 0,09691229 ! mRNA catabolic process GO:0006402 48 34 0,000 0,08039507 0,09686153 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,08039507 0,09681081 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,08039507 0,09676015 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,08039507 0,09670955 ! feeding behavior GO:0007631 45 34 0,000 0,08039507 0,09665899 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,08039507 0,09660849 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,08039507 0,09655804 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,08039507 0,09650765 ! neuron migration GO:0001764 46 34 0,000 0,08039507 0,0964573 ! female gamete generation GO:0007292 43 34 0,000 0,08039507 0,09640701 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,08039507 0,09635678 ! polyol metabolic process GO:0019751 44 34 0,000 0,08039507 0,09630659 ! aerobic respiration GO:0009060 47 34 0,000 0,08039507 0,09625646 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,08039507 0,09620638 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,08039507 0,09615635 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,0826614 0,0988156 ! Notch signaling pathway GO:0007219 56 35 0,000 0,0826614 0,09876427 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,0826614 0,09871299 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,0826614 0,09866177 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,0826614 0,09861059 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,0826614 0,09855947 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,0826614 0,09850841 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,0826614 0,09845739 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,0826614 0,09840643 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,0826614 0,09835552 ! pigment metabolic process GO:0042440 61 35 0,000 0,0826614 0,09830467 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,0826614 0,09825386 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,08492228 0,10088907 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,08492228 0,10083699 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,08492228 0,10078496 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,08492228 0,10073298 ! negative regulation of binding GO:0051100 58 36 0,000 0,08492228 0,10068105 ! neural tube development GO:0021915 50 36 0,000 0,08492228 0,10062918 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,08492228 0,10057737 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,08492228 0,1005256 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,08492228 0,10047389 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,08492228 0,10042223 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,08717772 0,10303636 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,08717772 0,10298344 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,08717772 0,10293057 ! learning GO:0007612 67 37 0,000 0,08717772 0,10287776 ! ion transmembrane transport GO:0034220 56 37 0,000 0,08717772 0,102825 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,08717772 0,1027723 ! regulation of protein secretion GO:0050708 51 37 0,000 0,08717772 0,10271965 ! amino acid activation GO:0043038 52 37 0,000 0,08717772 0,10266705 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,08717772 0,10261451 ! gliogenesis GO:0042063 71 38 0,000 0,08942772 0,10520909 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,08942772 0,1051553 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,08942772 0,10510157 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,08942772 0,10504789 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,08942772 0,10499426 ! phagocytosis GO:0006909 60 38 0,000 0,08942772 0,1049407 ! mesenchymal cell development GO:0014031 64 38 0,000 0,08942772 0,10488718 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,08942772 0,10483372 ! maintenance of location in cell GO:0051651 69 38 0,000 0,08942772 0,10478032 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,09167231 0,10735556 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,09167231 0,10730093 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,09167231 0,10724635 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,09167231 0,10719182 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,09167231 0,10713736 ! chromatin remodeling GO:0006338 68 39 0,000 0,09167231 0,10708294 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,09167231 0,10702859 ! JNK cascade GO:0007254 54 39 0,000 0,09167231 0,10697429 ! developmental growth GO:0048589 62 39 0,000 0,09167231 0,10692004 ! response to calcium ion GO:0051592 58 40 0,000 0,0939115 0,10947615 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,0939115 0,10942069 ! regulation of tube size GO:0035150 60 40 0,000 0,0939115 0,10936529 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,0939115 0,10930994 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,0939115 0,10925465 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,0939115 0,10919941 ! peptide metabolic process GO:0006518 56 40 0,000 0,0939115 0,10914424 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,0939115 0,10908911 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,0939115 0,10903404 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,0939115 0,10897903 ! double-strand break repair GO:0006302 67 40 0,000 0,0939115 0,10892408 ! B cell differentiation GO:0030183 62 40 0,000 0,0939115 0,10886917 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,0939115 0,10881433 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,0939115 0,10875954 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,0939115 0,1087048 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,09614529 0,11123449 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,09614529 0,11117856 ! glucose transport GO:0015758 52 41 0,000 0,09614529 0,1111227 ! endosome transport GO:0016197 71 41 0,000 0,09614529 0,11106688 ! striated muscle contraction GO:0006941 62 41 0,000 0,09614529 0,11101113 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,09614529 0,11095543 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,09614529 0,11089978 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,09614529 0,11084419 ! biopolymer methylation GO:0043414 62 41 0,000 0,09614529 0,11078866 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,09614529 0,11073318 ! mitochondrial transport GO:0006839 60 42 0,000 0,0983737 0,113243 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,0983737 0,11318635 ! cellular component disassembly GO:0022411 64 42 0,000 0,0983737 0,11312976 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,0983737 0,11307322 ! hexose transport GO:0008645 54 42 0,000 0,0983737 0,11301674 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,0983737 0,11296032 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,0983737 0,11290395 ! excretion GO:0007588 63 42 0,000 0,0983737 0,11284764 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,0983737 0,11279138 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,0983737 0,11273518 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,0983737 0,11267904 ! regulation of cell shape GO:0008360 78 42 0,000 0,0983737 0,11262295 ! positive regulation of binding GO:0051099 59 43 0,000 0,10059675 0,11511071 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,10059675 0,11505347 ! leukocyte migration GO:0050900 60 43 0,000 0,10059675 0,11499628 ! neuromuscular process GO:0050905 79 43 0,000 0,10059675 0,11493916 ! activation of caspase activity GO:0006919 65 43 0,000 0,10059675 0,11488209 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,10059675 0,11482507 ! tRNA processing GO:0008033 49 43 0,000 0,10059675 0,11476812 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,10059675 0,11471122 ! response to insulin stimulus GO:0032868 63 43 0,000 0,10059675 0,11465437 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,10059675 0,11459758 ! methylation GO:0032259 64 43 0,000 0,10059675 0,11454085 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,10281444 0,11700802 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,10281444 0,11695016 ! glycolysis GO:0006096 53 44 0,000 0,10281444 0,11689235 ! regulation of action potential GO:0001508 71 44 0,000 0,10281444 0,11683459 ! regulation of ion transport GO:0043269 57 44 0,000 0,10281444 0,1167769 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,10281444 0,11671926 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,10281444 0,11666167 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,10281444 0,11660415 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,10281444 0,11654668 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,10281444 0,11648927 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,10281444 0,11643191 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,10281444 0,11637461 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,10281444 0,11631737 ! RNA catabolic process GO:0006401 64 45 0,000 0,10502679 0,11876186 ! positive regulation of defense response GO:0031349 59 45 0,000 0,10502679 0,1187035 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,10502679 0,1186452 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,10502679 0,11858695 ! cell recognition GO:0008037 58 45 0,000 0,10502679 0,11852876 ! cell maturation GO:0048469 60 45 0,000 0,10502679 0,11847063 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,10723381 0,12090087 ! cell redox homeostasis GO:0045454 63 46 0,000 0,10723381 0,12084163 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,10723381 0,12078245 ! histone modification GO:0016570 68 46 0,000 0,10723381 0,12072333 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,10723381 0,12066427 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,10943552 0,12308151 ! viral infectious cycle GO:0019058 71 47 0,000 0,10943552 0,12302136 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,10943552 0,12296126 ! endocrine system development GO:0035270 83 47 0,000 0,10943552 0,12290122 ! covalent chromatin modification GO:0016569 75 47 0,000 0,10943552 0,12284124 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,10943552 0,12278132 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,10943552 0,12272145 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,10943552 0,12266165 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,10943552 0,1226019 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,10943552 0,12254221 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,10943552 0,12248258 ! chloride transport GO:0006821 67 48 0,000 0,11163192 0,12488007 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,11163192 0,12481936 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 0,000 0,11163192 0,12475871 ! heart morphogenesis GO:0003007 65 48 0,000 0,11163192 0,12469812 ! regulation of DNA replication GO:0006275 75 48 0,000 0,11163192 0,12463758 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,11163192 0,12457711 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,11163192 0,12451669 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,11163192 0,12445634 ! regulation of endocytosis GO:0030100 63 48 0,000 0,11163192 0,12439604 ! nuclear export GO:0051168 69 48 0,000 0,11163192 0,1243358 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,11163192 0,12427562 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,11163192 0,12421549 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,11382303 0,12659235 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,11382303 0,12653116 ! sensory perception of smell GO:0007608 61 49 0,000 0,11382303 0,12647004 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,11382303 0,12640897 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,11382303 0,12634796 ! RNA elongation GO:0006354 62 49 0,000 0,11382303 0,12628701 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,11382303 0,12622612 ! germ cell development GO:0007281 68 49 0,000 0,11382303 0,12616529 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,11382303 0,12610452 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,11382303 0,1260438 ! maintenance of location GO:0051235 84 49 0,000 0,11382303 0,12598315 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,11600887 0,12834074 ! lipid modification GO:0030258 73 50 0,000 0,11600887 0,12827903 ! positive regulation of growth GO:0045927 67 50 0,000 0,11600887 0,12821739 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,11600887 0,12815581 ! proton transport GO:0015992 75 50 0,000 0,11600887 0,12809428 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,11600887 0,12803282 ! positive regulation of secretion GO:0051047 71 51 0,000 0,11818943 0,13037683 ! hydrogen transport GO:0006818 77 51 0,000 0,11818943 0,13031433 ! muscle fiber development GO:0048747 74 51 0,000 0,11818943 0,13025189 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,11818943 0,13018951 ! adult behavior GO:0030534 80 51 0,000 0,11818943 0,13012719 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,11818943 0,13006492 ! transition metal ion transport GO:0000041 74 52 0,000 0,12036474 0,13239546 ! aging GO:0007568 79 52 0,000 0,12036474 0,13233217 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,12036474 0,13226895 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,12036474 0,13220578 ! establishment of organelle localization GO:0051656 85 52 0,000 0,12036474 0,13214268 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,12253481 0,13446091 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,12253481 0,13439679 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,12253481 0,13433273 ! kidney development GO:0001822 90 53 0,000 0,12253481 0,13426873 ! single fertilization GO:0007338 59 53 0,000 0,12253481 0,13420479 ! cell projection assembly GO:0030031 76 53 0,000 0,12253481 0,13414092 ! amino acid transport GO:0006865 84 54 0,000 0,12469965 0,13644586 ! regulation of mitosis GO:0007088 84 54 0,000 0,12469965 0,13638098 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,12469965 0,13631616 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,12469965 0,1362514 ! DNA catabolic process GO:0006308 67 54 0,000 0,12469965 0,13618671 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,12469965 0,13612207 ! exocytosis GO:0006887 74 55 0,000 0,12685928 0,13841382 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,12685928 0,13834819 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,12685928 0,13828262 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,12901369 0,14056442 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,12901369 0,14049787 ! carbohydrate transport GO:0008643 74 57 0,000 0,13116292 0,14277081 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,13116292 0,14270327 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,13116292 0,1426358 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,13116292 0,14256839 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,13116292 0,14250105 ! camera-type eye development GO:0043010 88 57 0,000 0,13116292 0,14243377 ! secondary metabolic process GO:0019748 84 57 0,000 0,13116292 0,14236655 ! response to peptide hormone stimulus GO:0043434 84 57 0,000 0,13116292 0,14229939 ! viral reproductive process GO:0022415 87 58 0,000 0,13330697 0,14455729 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,13330697 0,14448917 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,13330697 0,14442111 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,13330697 0,14435312 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,13544584 0,14660021 ! activation of MAPK activity GO:0000187 84 59 0,000 0,13544584 0,14653125 ! actin filament organization GO:0007015 95 59 0,000 0,13544584 0,14646236 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,13544584 0,14639353 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,13544584 0,14632477 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,13757956 0,14856009 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,13757956 0,14849038 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,13757956 0,14842073 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,13757956 0,14835115 ! regulation of heart contraction GO:0008016 91 60 0,000 0,13757956 0,14828163 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,13757956 0,14821218 ! fertilization GO:0009566 68 60 0,000 0,13757956 0,14814279 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,13757956 0,14807347 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,13970814 0,15029407 ! meiosis GO:0007126 96 61 0,000 0,13970814 0,15022381 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,13970814 0,15015361 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,13970814 0,15008348 ! urogenital system development GO:0001655 101 61 0,000 0,13970814 0,15001341 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,13970814 0,14994341 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,13970814 0,14987347 ! extracellular matrix organization GO:0030198 103 61 0,000 0,13970814 0,1498036 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,13970814 0,1497338 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,13970814 0,14966406 ! amine catabolic process GO:0009310 90 62 0,000 0,14183159 0,15186809 ! neurotransmitter transport GO:0006836 81 62 0,000 0,14183159 0,15179742 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,14183159 0,15172682 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,14183159 0,15165628 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,14183159 0,15158581 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,14183159 0,1515154 ! meiotic cell cycle GO:0051321 97 62 0,000 0,14183159 0,15144506 ! organelle localization GO:0051640 96 62 0,000 0,14183159 0,15137478 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,14394991 0,15356438 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,14394991 0,15349319 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,14394991 0,15342206 ! viral reproduction GO:0016032 92 63 0,000 0,14394991 0,153351 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,14606313 0,15553019 ! negative regulation of cell size GO:0045792 108 64 0,000 0,14606313 0,15545822 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,14606313 0,15538631 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,14606313 0,15531447 ! hexose catabolic process GO:0019320 82 64 0,000 0,14606313 0,1552427 ! adaptive immune response GO:0002250 94 64 0,000 0,14606313 0,155171 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 0,000 0,14817126 0,1573379 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,14817126 0,15726529 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,14817126 0,15719275 ! defense response to bacterium GO:0042742 73 65 0,000 0,14817126 0,15712028 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,14817126 0,15704787 ! activation of immune response GO:0002253 83 65 0,000 0,14817126 0,15697554 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,1502743 0,15913024 ! antigen processing and presentation GO:0019882 96 66 0,000 0,1502743 0,15905701 ! axon guidance GO:0007411 99 66 0,000 0,1502743 0,15898384 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,1502743 0,15891075 ! regulation of immune effector process GO:0002697 101 66 0,000 0,1502743 0,15883772 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,15237226 0,16098126 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,15237226 0,16090735 ! acute inflammatory response GO:0002526 92 68 0,000 0,15446517 0,16304263 ! learning or memory GO:0007611 123 68 0,000 0,15446517 0,16296784 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,15446517 0,16289312 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,15446517 0,16281847 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,15446517 0,16274388 ! rhythmic process GO:0048511 105 68 0,000 0,15446517 0,16266936 ! inorganic anion transport GO:0015698 93 68 0,000 0,15446517 0,16259492 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,15655303 0,16471728 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,15655303 0,16464196 ! response to drug GO:0042493 108 69 0,000 0,15655303 0,16456671 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,15655303 0,16449154 ! response to metal ion GO:0010038 103 70 0,000 0,15863586 0,16660387 ! humoral immune response GO:0006959 86 70 0,000 0,15863586 0,16652783 ! eye development GO:0001654 111 70 0,000 0,15863586 0,16645186 ! amine transport GO:0015837 101 70 0,000 0,15863586 0,16637595 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,15863586 0,16630012 ! regulation of catabolic process GO:0009894 106 70 0,000 0,15863586 0,16622436 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,16071366 0,16832487 ! muscle cell differentiation GO:0042692 104 71 0,000 0,16071366 0,16824825 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,16071366 0,16817171 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,16071366 0,16809523 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,16071366 0,16801882 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,16071366 0,16794248 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,16278644 0,17003125 ! negative regulation of transport GO:0051051 116 73 0,000 0,16485423 0,17211291 ! tube morphogenesis GO:0035239 118 73 0,000 0,16485423 0,17203481 ! mitochondrion organization GO:0007005 104 73 0,000 0,16485423 0,17195679 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,16485423 0,17187885 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,16485423 0,17180097 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,16691703 0,17387191 ! digestion GO:0007586 97 74 0,000 0,16691703 0,1737932 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,16691703 0,17371456 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,16691703 0,17363599 ! blood coagulation GO:0007596 116 75 0,000 0,16897485 0,17569718 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,16897485 0,17561779 ! negative regulation of growth GO:0045926 123 75 0,000 0,16897485 0,17553846 ! response to nutrient GO:0007584 104 75 0,000 0,16897485 0,17545921 ! regulation of ligase activity GO:0051340 114 75 0,000 0,16897485 0,17538004 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,16897485 0,17530093 ! amine biosynthetic process GO:0009309 97 76 0,000 0,17102771 0,17735065 ! tRNA metabolic process GO:0006399 95 76 0,000 0,17102771 0,17727072 ! response to unfolded protein GO:0006986 99 76 0,000 0,17102771 0,17719087 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,17102771 0,17711109 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,17307561 0,17915117 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,17307561 0,17907058 ! regulation of DNA binding GO:0051101 119 77 0,000 0,17307561 0,17899007 ! protein ubiquitination GO:0016567 125 77 0,000 0,17307561 0,17890962 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,17307561 0,17882925 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,17307561 0,17874895 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,17307561 0,17866872 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,17511857 0,1806966 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,17511857 0,18061557 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,17511857 0,18053461 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,17715661 0,18255385 ! cellular respiration GO:0045333 107 79 0,000 0,17715661 0,1824721 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,17715661 0,18239042 ! T cell activation GO:0042110 134 79 0,000 0,17715661 0,18230881 ! regulation of lyase activity GO:0051339 133 79 0,000 0,17715661 0,18222728 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,17715661 0,18214582 ! chromatin assembly GO:0031497 102 80 0,000 0,17918972 0,18415387 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,17918972 0,18407162 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,17918972 0,18398944 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,17918972 0,18390734 ! forebrain development GO:0030900 131 80 0,000 0,17918972 0,18382531 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,18121793 0,18582311 ! hemostasis GO:0007599 125 81 0,000 0,18121793 0,1857403 ! mRNA transport GO:0051028 121 81 0,000 0,18121793 0,18565756 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,18121793 0,1855749 ! response to protein stimulus GO:0051789 111 81 0,000 0,18121793 0,18549231 ! regulation of neurological system process GO:0031644 122 81 0,000 0,18121793 0,1854098 ! vitamin metabolic process GO:0006766 103 81 0,000 0,18121793 0,18532736 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,18121793 0,18524499 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,18525966 0,18929241 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,18525966 0,18920836 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,18525966 0,18912438 ! regulation of defense response GO:0031347 117 84 0,000 0,18727322 0,19109512 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,18727322 0,19101038 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,18727322 0,19092571 ! sterol metabolic process GO:0016125 120 84 0,000 0,18727322 0,19084112 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,18928191 0,19280266 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,18928191 0,19271731 ! rRNA metabolic process GO:0016072 107 85 0,000 0,18928191 0,19263203 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,18928191 0,19254684 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,19128576 0,19449922 ! cell cycle arrest GO:0007050 150 86 0,000 0,19128576 0,19441327 ! nucleosome organization GO:0034728 114 87 0,000 0,19328476 0,19635819 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,19328476 0,1962715 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,19328476 0,19618489 ! female pregnancy GO:0007565 130 87 0,000 0,19328476 0,19609835 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,19527894 0,1980342 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,19527894 0,19794692 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,19527894 0,19785972 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,19527894 0,1977726 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,19726831 0,19969943 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,19726831 0,19961157 ! regulation of T cell activation GO:0050863 128 89 0,000 0,19726831 0,19952379 ! leukocyte differentiation GO:0002521 143 90 0,000 0,19925287 0,20144246 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,19925287 0,20135395 ! hormone metabolic process GO:0042445 121 90 0,000 0,19925287 0,20126552 ! RNA localization GO:0006403 135 91 0,000 0,20123263 0,20317606 ! ATP metabolic process GO:0046034 137 91 0,000 0,20123263 0,20308691 ! response to virus GO:0009615 122 91 0,000 0,20123263 0,20299783 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,20320762 0,20490028 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,20320762 0,20481049 ! positive regulation of immune response GO:0050778 121 92 0,000 0,20320762 0,20472077 ! DNA recombination GO:0006310 146 92 0,000 0,20320762 0,20463114 ! sulfur metabolic process GO:0006790 118 92 0,000 0,20320762 0,20454159 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,20517784 0,2064344 ! electron transport chain GO:0022900 123 94 0,000 0,2071433 0,20832076 ! response to oxidative stress GO:0006979 141 94 0,000 0,2071433 0,20822971 ! regulation of binding GO:0051098 151 95 0,000 0,20910401 0,21010888 ! carboxylic acid transport GO:0046942 147 95 0,000 0,20910401 0,21001712 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,21105998 0,21188911 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,21105998 0,21179667 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,21105998 0,2117043 ! protein maturation GO:0051604 129 96 0,000 0,21105998 0,21161201 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,21301123 0,21347531 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,21301123 0,21338233 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,21883674 0,21912255 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,21883674 0,2190272 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,21883674 0,21893193 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,21883674 0,21883674