pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/793-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of DNA metabolic process GO:0051052 135 85 5,000 3,714E-08 8,542E-05 ! nuclear migration GO:0007097 10 5 2,000 1,106E-07 1,272E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 1,106E-07 8,481E-05 GO:0031272|regulation of pseudopodium assembly, ! macrophage differentiation GO:0030225 10 6 2,000 2,209E-07 1,27E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 2,415E-07 1,111E-04 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 3,859E-07 1,479E-04 ! establishment of nucleus localization GO:0040023 13 7 2,000 3,859E-07 1,268E-04 ! negative regulation of telomere maintenance GO:0032205 9 7 2,000 3,859E-07 1,11E-04 ! regulation of telomere maintenance GO:0032204 10 8 2,000 6,165E-07 1,576E-04 ! telomere maintenance via telomerase GO:0007004 12 9 2,000 9,233E-07 2,124E-04 GO:0010833|telomere maintenance via telomere lengthening, ! nucleus localization GO:0051647 15 9 2,000 9,233E-07 1,931E-04 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 1,037E-06 1,987E-04 ! regulation of cell projection assembly GO:0060491 20 10 2,000 1,317E-06 2,33E-04 ! regulation of sodium ion transport GO:0002028 15 10 2,000 1,317E-06 2,164E-04 ! RNA-dependent DNA replication GO:0006278 13 10 2,000 1,317E-06 2,019E-04 ! filopodium assembly GO:0046847 19 11 2,000 1,808E-06 2,599E-04 ! microspike assembly GO:0030035 23 12 2,000 2,407E-06 3,256E-04 ! response to insulin stimulus GO:0032868 63 43 3,000 2,718E-06 3,474E-04 ! establishment of organelle localization GO:0051656 85 52 3,000 5,876E-06 7,113E-04 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 2,000 6,087E-06 7E-04 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 7,38E-06 8,083E-04 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 8,503E-06 8,889E-04 ! organelle localization GO:0051640 96 62 3,000 1,191E-05 1,191E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 1,434E-05 1,375E-03 ! regulation of DNA recombination GO:0000018 40 21 2,000 1,434E-05 1,32E-03 ! interaction with host GO:0051701 37 23 2,000 1,904E-05 1,684E-03 ! telomere organization GO:0032200 32 23 2,000 1,904E-05 1,622E-03 GO:0000723|telomere maintenance, ! negative regulation of organelle organization GO:0010639 115 72 3,000 2,161E-05 1,775E-03 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 2,172E-05 1,723E-03 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 2,408E-05 1,846E-03 ! regulation of chromosome organization GO:0033044 35 25 2,000 2,465E-05 1,829E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 3,494E-05 2,511E-03 ! positive regulation of catabolic process GO:0009896 40 28 2,000 3,494E-05 2,435E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 5,083E-05 3,438E-03 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 1,000 5,083E-05 3,34E-03 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! valine metabolic process GO:0006573 8 5 1,000 5,083E-05 3,247E-03 ! negative regulation of T cell mediated immunity GO:0002710 11 5 1,000 5,083E-05 3,159E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! regulation of respiratory burst GO:0060263 8 5 1,000 5,083E-05 3,076E-03 ! leukocyte differentiation GO:0002521 143 90 3,000 5,209E-05 3,072E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 5,257E-05 3,022E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 2,000 5,257E-05 2,949E-03 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 5,773E-05 3,161E-03 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 6,322E-05 3,381E-03 ! regulation of metal ion transport GO:0010959 47 35 2,000 6,903E-05 3,609E-03 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 7,613E-05 3,891E-03 GO:0031958|corticosteroid receptor signaling pathway, ! male sex determination GO:0030238 9 6 1,000 7,613E-05 3,806E-03 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 1,000 7,613E-05 3,725E-03 ! spindle checkpoint GO:0031577 14 6 1,000 7,613E-05 3,648E-03 ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 7,613E-05 3,573E-03 ! G2 phase GO:0051319 13 6 1,000 7,613E-05 3,502E-03 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 1,000 7,613E-05 3,433E-03 GO:0050000|chromosome localization, ! receptor internalization GO:0031623 9 6 1,000 7,613E-05 3,367E-03 ! regulation of Rac protein signal transduction GO:0035020 8 6 1,000 7,613E-05 3,304E-03 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 1,000 7,613E-05 3,242E-03 ! Ras protein signal transduction GO:0007265 162 100 3,000 7,864E-05 3,288E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 1,064E-04 4,371E-03 ! lymph node development GO:0048535 9 7 1,000 1,064E-04 4,294E-03 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 1,000 1,064E-04 4,22E-03 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 1,000 1,064E-04 4,149E-03 ! regulation of cell projection organization GO:0031344 83 44 2,000 1,377E-04 5,279E-03 ! regulation of ion transport GO:0043269 57 44 2,000 1,377E-04 5,192E-03 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 1,000 1,417E-04 5,256E-03 GO:0046579|positive regulation of Ras protein signal transduction, ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,417E-04 5,173E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,417E-04 5,092E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,417E-04 5,014E-03 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 1,000 1,417E-04 4,938E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 1,417E-04 4,864E-03 ! negative regulation of immune system process GO:0002683 73 47 2,000 1,678E-04 5,676E-03 ! regulation of DNA replication GO:0006275 75 48 2,000 1,787E-04 5,957E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 1,819E-04 5,977E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,819E-04 5,893E-03 ! regulation of glycolysis GO:0006110 15 9 1,000 1,819E-04 5,811E-03 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 1,000 1,819E-04 5,731E-03 GO:0002820|negative regulation of adaptive immune response, ! pyrimidine base metabolic process GO:0006206 14 9 1,000 1,819E-04 5,654E-03 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 2,271E-04 6,963E-03 ! pathogenesis GO:0009405 13 10 1,000 2,271E-04 6,872E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,271E-04 6,782E-03 GO:0043470|regulation of carbohydrate catabolic process, ! negative regulation of immune effector process GO:0002698 16 10 1,000 2,271E-04 6,695E-03 ! cell projection assembly GO:0030031 76 53 2,000 2,401E-04 6,991E-03 ! regulation of protein complex assembly GO:0043254 81 54 2,000 2,539E-04 7,298E-03 ! virus-host interaction GO:0019048 17 11 1,000 2,771E-04 7,869E-03 ! focal adhesion formation GO:0048041 24 11 1,000 2,771E-04 7,773E-03 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 2,828E-04 7,837E-03 ! viral reproductive process GO:0022415 87 58 2,000 3,138E-04 8,592E-03 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 3,138E-04 8,491E-03 ! myeloid cell differentiation GO:0030099 85 59 2,000 3,301E-04 8,828E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 3,321E-04 8,779E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 3,321E-04 8,679E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! positive regulation of homeostatic process GO:0032846 15 12 1,000 3,321E-04 8,581E-03 ! regulation of homeostatic process GO:0032844 105 60 2,000 3,469E-04 8,866E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 4,007E-04 0,01012696 ! viral reproduction GO:0016032 92 63 2,000 4,007E-04 0,01001689 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,565E-04 0,01129018 ! lysosomal transport GO:0007041 20 14 1,000 4,565E-04 0,01117007 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 5,26E-04 0,01273442 ! lipid phosphorylation GO:0046834 23 15 1,000 5,26E-04 0,01260177 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 5,26E-04 0,01247186 ! regulation of catabolic process GO:0009894 106 70 2,000 5,462E-04 0,01281968 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 6,003E-04 0,0139454 ! negative regulation of immune response GO:0050777 28 16 1,000 6,003E-04 0,01380594 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 6,003E-04 0,01366925 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 6,003E-04 0,01353524 ! protein import into nucleus GO:0006606 118 74 2,000 6,428E-04 0,01435319 ! nuclear import GO:0051170 121 75 2,000 6,685E-04 0,01478408 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 6,793E-04 0,0148801 ! negative regulation of ion transport GO:0043271 20 17 1,000 6,793E-04 0,01473972 ! vacuolar transport GO:0007034 24 17 1,000 6,793E-04 0,01460197 ! cell-substrate junction assembly GO:0007044 39 17 1,000 6,793E-04 0,01446676 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 6,793E-04 0,01433404 ! actin filament bundle formation GO:0051017 26 17 1,000 6,793E-04 0,01420373 ! nucleobase metabolic process GO:0009112 31 17 1,000 6,793E-04 0,01407577 ! positive regulation of DNA replication GO:0045740 29 18 1,000 7,631E-04 0,01567116 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 7,631E-04 0,01553247 ! visual learning GO:0008542 35 18 1,000 7,631E-04 0,01539622 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 7,631E-04 0,01526234 ! T cell activation GO:0042110 134 79 2,000 7,779E-04 0,01542477 ! protein localization in nucleus GO:0034504 133 80 2,000 8,07E-04 0,01586365 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 8,517E-04 0,0166002 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 8,517E-04 0,0164607 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 8,517E-04 0,01632353 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 8,517E-04 0,01618862 ! sensory perception of taste GO:0050909 23 19 1,000 8,517E-04 0,01605593 ! sex determination GO:0007530 29 19 1,000 8,517E-04 0,01592539 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 8,517E-04 0,01579696 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 8,517E-04 0,01567059 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 9,449E-04 0,0172486 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 1,000 9,449E-04 0,01711278 ! regulation of cell killing GO:0031341 34 21 1,000 1,043E-03 0,01873923 ! visual behavior GO:0007632 39 21 1,000 1,043E-03 0,01859397 ! cell aging GO:0007569 32 21 1,000 1,043E-03 0,01845094 ! anatomical structure homeostasis GO:0060249 136 88 2,000 1,064E-03 0,0186859 ! protein tetramerization GO:0051262 39 22 1,000 1,146E-03 0,01995962 ! negative regulation of DNA replication GO:0008156 35 23 1,000 1,253E-03 0,02166482 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 1,253E-03 0,02150314 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 1,365E-03 0,02325056 ! receptor metabolic process GO:0043112 37 24 1,000 1,365E-03 0,0230796 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 1,368E-03 0,02297192 ! response to light stimulus GO:0009416 153 96 2,000 1,368E-03 0,02280546 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 1,481E-03 0,02450963 ! protein import GO:0017038 156 99 2,000 1,495E-03 0,02456079 ! protein localization in organelle GO:0033365 161 100 2,000 1,539E-03 0,02510115 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 1,728E-03 0,02798939 ! cell junction assembly GO:0034329 56 28 1,000 1,858E-03 0,02988841 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 1,858E-03 0,02968085 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 2,276E-03 0,03610351 ! regulation of muscle development GO:0048634 48 32 1,000 2,424E-03 0,03819144 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 2,424E-03 0,03793163 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 2,424E-03 0,03767534 ! cell junction organization GO:0034330 63 33 1,000 2,577E-03 0,03977934 ! carbohydrate homeostasis GO:0033500 39 33 1,000 2,577E-03 0,03951415 GO:0042593|glucose homeostasis, ! androgen receptor signaling pathway GO:0030521 54 33 1,000 2,577E-03 0,03925247 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 2,734E-03 0,04137158 ! learning GO:0007612 67 37 1,000 3,232E-03 0,04858305 ! striated muscle cell differentiation GO:0051146 54 38 1,000 3,406E-03 0,05087563 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 3,585E-03 0,05320286 ! cell growth GO:0016049 61 39 1,000 3,585E-03 0,05286182 ! response to calcium ion GO:0051592 58 40 1,000 3,769E-03 0,05520988 ! T cell differentiation GO:0030217 65 40 1,000 3,769E-03 0,05486045 ! glucose transport GO:0015758 52 41 1,000 3,956E-03 0,05722846 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 3,956E-03 0,05687079 ! regulation of T cell differentiation GO:0045580 59 41 1,000 3,956E-03 0,05651755 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 4,148E-03 0,05889211 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 4,148E-03 0,0585308 ! hexose transport GO:0008645 54 42 1,000 4,148E-03 0,05817391 GO:0015749|monosaccharide transport, ! excretion GO:0007588 63 42 1,000 4,148E-03 0,05782134 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 4,344E-03 0,06018971 ! activation of caspase activity GO:0006919 65 43 1,000 4,344E-03 0,0598293 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 4,344E-03 0,05947317 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 4,749E-03 0,06463068 ! regulation of adaptive immune response GO:0002819 72 46 1,000 4,958E-03 0,06707421 ! response to UV GO:0009411 75 46 1,000 4,958E-03 0,06668196 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 5,171E-03 0,06914096 ! positive regulation of caspase activity GO:0043280 72 48 1,000 5,388E-03 0,07162676 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 65 48 1,000 5,388E-03 0,07121511 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 5,388E-03 0,07080816 ! regulation of intracellular transport GO:0032386 78 49 1,000 5,609E-03 0,07329615 ! lipid modification GO:0030258 73 50 1,000 5,834E-03 0,0758095 ! positive regulation of growth GO:0045927 67 50 1,000 5,834E-03 0,0753836 ! positive regulation of cell migration GO:0030335 92 51 1,000 6,063E-03 0,07790984 ! regulation of protein catabolic process GO:0042176 77 51 1,000 6,063E-03 0,07747701 ! positive regulation of organelle organization GO:0010638 82 51 1,000 6,063E-03 0,07704896 ! aging GO:0007568 79 52 1,000 6,297E-03 0,07957594 ! regulation of mitosis GO:0007088 84 54 1,000 6,776E-03 0,0851623 GO:0051783|regulation of nuclear division, ! negative regulation of response to stimulus GO:0048585 80 56 1,000 7,271E-03 0,090889 ! positive regulation of cell motion GO:0051272 99 56 1,000 7,271E-03 0,09039771 ! carbohydrate transport GO:0008643 74 57 1,000 7,525E-03 0,0930472 ! chromosome segregation GO:0007059 83 57 1,000 7,525E-03 0,09254962 ! activation of MAPK activity GO:0000187 84 59 1,000 8,044E-03 0,09840692 ! actin filament organization GO:0007015 95 59 1,000 8,044E-03 0,09788625 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 8,309E-03 0,10058387 ! cell-matrix adhesion GO:0007160 114 61 1,000 8,578E-03 0,10330032 ! homeostasis of number of cells GO:0048872 84 61 1,000 8,578E-03 0,1027623 ! cell cycle checkpoint GO:0000075 108 64 1,000 9,41E-03 0,11213562 ! regulation of caspase activity GO:0043281 97 65 1,000 9,694E-03 0,11493376 ! positive regulation of T cell activation GO:0050870 94 65 1,000 9,694E-03 0,11434436 ! protein oligomerization GO:0051259 100 65 1,000 9,694E-03 0,11376097 ! cell-substrate adhesion GO:0031589 121 66 1,000 9,983E-03 0,11655283 ! regulation of immune effector process GO:0002697 101 66 1,000 9,983E-03 0,11596418 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,01027539 0,11876084 ! learning or memory GO:0007611 123 68 1,000 0,01057157 0,12157303 ! sensory perception of chemical stimulus GO:0007606 85 69 1,000 0,01087151 0,12440031 ! response to drug GO:0042493 108 69 1,000 0,01087151 0,12378447 ! response to metal ion GO:0010038 103 70 1,000 0,01117519 0,12661545 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,0113894 0,12840993 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,0113894 0,12778354 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,0113894 0,12716324 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,0113894 0,12654892 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,0113894 0,12594051 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,0113894 0,12533793 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,0113894 0,12474108 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,0113894 0,12414989 ! sleep GO:0030431 11 5 0,000 0,0113894 0,12356428 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,0113894 0,12298416 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,0113894 0,12240947 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,0113894 0,12184012 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,0113894 0,12127605 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,0113894 0,12071717 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,0113894 0,12016342 ! tongue development GO:0043586 6 5 0,000 0,0113894 0,11961473 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,0113894 0,11907103 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,0113894 0,11853225 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,0113894 0,11799832 ! cobalt ion transport GO:0006824 9 5 0,000 0,0113894 0,11746918 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,0113894 0,11694476 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,0113894 0,11642501 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,0113894 0,11590985 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,0113894 0,11539924 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,0113894 0,1148931 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,0113894 0,11439138 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,0113894 0,11389403 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,0113894 0,11340098 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,0113894 0,11291218 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,0113894 0,11242758 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,0113894 0,11194712 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,0113894 0,11147075 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,0113894 0,11099842 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,0113894 0,11053007 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,0113894 0,11006566 ! malate metabolic process GO:0006108 7 5 0,000 0,0113894 0,10960513 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,0113894 0,10914844 ! behavioral response to pain GO:0048266 7 5 0,000 0,0113894 0,10869555 ! clathrin coat assembly GO:0048268 11 5 0,000 0,0113894 0,10824639 ! phototransduction, visible light GO:0007603 6 5 0,000 0,0113894 0,10780093 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,0113894 0,10735913 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,0113894 0,10692092 ! mating behavior GO:0007617 6 5 0,000 0,0113894 0,10648629 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,0113894 0,10605517 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,0113894 0,10562753 ! rhythmic behavior GO:0007622 12 5 0,000 0,0113894 0,10520332 ! copulation GO:0007620 7 5 0,000 0,0113894 0,10478251 ! glial cell fate commitment GO:0021781 12 5 0,000 0,0113894 0,10436505 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,0113894 0,1039509 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,0113894 0,10354003 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,0113894 0,10313239 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,0113894 0,10272795 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,0113894 0,10232667 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,0113894 0,10192851 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,0113894 0,10153344 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,0113894 0,10114142 ! response to protozoan GO:0001562 9 5 0,000 0,0113894 0,10075241 ! lymph vessel development GO:0001945 7 5 0,000 0,0113894 0,10036639 ! endochondral ossification GO:0001958 12 5 0,000 0,0113894 0,09998331 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,0113894 0,09960314 ! parathyroid gland development GO:0060017 8 5 0,000 0,0113894 0,09922586 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,0113894 0,09885142 ! anagen GO:0042640 6 5 0,000 0,0113894 0,0984798 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,0113894 0,09811096 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,0113894 0,09774488 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,0113894 0,09738151 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,0113894 0,09702084 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,0113894 0,09666283 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,0113894 0,09630745 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,0113894 0,09595468 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,0113894 0,09560448 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,0113894 0,09525682 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,0113894 0,09491169 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,0113894 0,09456905 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,0113894 0,09422887 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,0113894 0,09389113 ! ovulation GO:0030728 6 5 0,000 0,0113894 0,09355581 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,0113894 0,09322287 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,0113894 0,09289229 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,0113894 0,09256405 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,0113894 0,09223812 ! proline biosynthetic process GO:0006561 6 5 0,000 0,0113894 0,09191448 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,0113894 0,0915931 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,0113894 0,09127396 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,0113894 0,09095704 ! polyol catabolic process GO:0046174 7 5 0,000 0,0113894 0,09064231 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,0113894 0,09032975 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,0113894 0,09001934 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,0113894 0,08971105 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,0113894 0,08940487 ! nerve growth factor processing GO:0032455 7 5 0,000 0,0113894 0,08910077 ! urea metabolic process GO:0019627 6 5 0,000 0,0113894 0,08879873 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,0113894 0,08849874 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,0113894 0,08820076 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,0113894 0,08790479 ! neutrophil activation GO:0042119 5 5 0,000 0,0113894 0,08761079 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,0113894 0,08731876 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,0113894 0,08702866 ! response to food GO:0032094 5 5 0,000 0,0113894 0,08674049 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,0113894 0,08645421 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,0113894 0,08616982 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,0113894 0,0858873 ! forebrain neuron development GO:0021884 7 5 0,000 0,0113894 0,08560662 ! melanosome organization GO:0032438 7 5 0,000 0,0113894 0,08532777 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,0113894 0,08505074 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,0113894 0,08477549 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,0113894 0,08450202 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,0113894 0,08423031 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,0113894 0,08396034 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,0113894 0,0836921 ! nucleoside transport GO:0015858 6 5 0,000 0,0113894 0,08342556 ! nucleoside salvage GO:0043174 7 5 0,000 0,0113894 0,08316072 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,0113894 0,08289755 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,0113894 0,08263605 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,0113894 0,08237618 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,0113894 0,08211795 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,0113894 0,08186133 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,0113894 0,08160631 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,0113894 0,08135288 ! depyrimidination GO:0045008 8 5 0,000 0,0113894 0,08110101 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,0113894 0,0808507 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,0113894 0,08060193 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,0113894 0,08035468 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,0113894 0,08010895 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,0113894 0,07986472 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,0113894 0,07962197 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,0113894 0,07938069 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,0113894 0,07914087 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,0113894 0,07890249 ! monocyte differentiation GO:0030224 8 5 0,000 0,0113894 0,07866555 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,0113894 0,07843002 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,0113894 0,0781959 ! centrosome duplication GO:0051298 5 5 0,000 0,0113894 0,07796317 ! response to UV-C GO:0010225 6 5 0,000 0,0113894 0,07773183 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,0113894 0,07750185 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,0113894 0,07727323 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,0113894 0,07704596 ! regulation of dendrite development GO:0050773 12 5 0,000 0,0113894 0,07682002 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,0113894 0,0765954 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,0113894 0,07637209 ! melanosome transport GO:0032402 8 5 0,000 0,0113894 0,07615008 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,0113894 0,07592935 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,0113894 0,0757099 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,0113894 0,07549172 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,0113894 0,07527479 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,0113894 0,0750591 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,0113894 0,07484465 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,0113894 0,07463141 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,0113894 0,07441939 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,0113894 0,07420857 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,0113894 0,07399895 ! neural tube patterning GO:0021532 6 5 0,000 0,0113894 0,0737905 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,0113894 0,07358322 ! histone demethylation GO:0016577 9 5 0,000 0,0113894 0,07337711 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,0113894 0,07317214 ! regulation of sterol transport GO:0032371 7 5 0,000 0,0113894 0,07296832 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,0113894 0,07276563 ! enteric nervous system development GO:0048484 8 5 0,000 0,0113894 0,07256406 ! establishment of planar polarity GO:0001736 6 5 0,000 0,0113894 0,07236361 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,0113894 0,07216426 ! muscle cell proliferation GO:0033002 8 5 0,000 0,0113894 0,07196601 ! transcription termination GO:0006353 8 5 0,000 0,0113894 0,07176884 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,0113894 0,07157275 ! plasminogen activation GO:0031639 5 5 0,000 0,0113894 0,07137773 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,0113894 0,07118377 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,0113894 0,07099086 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,0113894 0,07079899 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,0113894 0,07060816 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,0113894 0,07041835 ! apical protein localization GO:0045176 6 5 0,000 0,0113894 0,07022956 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,0113894 0,07004178 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,0113894 0,069855 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,0113894 0,06966922 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,0113894 0,06948442 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,0113894 0,0693006 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,0113894 0,06911775 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,0113894 0,06893586 ! glial cell migration GO:0008347 10 5 0,000 0,0113894 0,06875493 ! determination of adult lifespan GO:0008340 8 5 0,000 0,0113894 0,06857494 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,0113894 0,06839589 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,0113894 0,06821778 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,0113894 0,06804059 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,0113894 0,06786432 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,0113894 0,06768896 ! neural plate development GO:0001840 6 5 0,000 0,0113894 0,0675145 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,0113894 0,06734094 ! regulation of sensory perception GO:0051931 6 5 0,000 0,0113894 0,06716827 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,0113894 0,06699649 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,0113894 0,06682558 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,0113894 0,06665554 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,0113894 0,06648636 ! sensory cilium assembly GO:0035058 6 5 0,000 0,0113894 0,06631804 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,0113894 0,06615057 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,0113894 0,06598395 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,0113894 0,06581816 ! spindle assembly GO:0051225 5 5 0,000 0,0113894 0,0656532 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,0113894 0,06548907 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,0113894 0,06532575 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,0113894 0,06516325 ! organ regeneration GO:0031100 7 5 0,000 0,0113894 0,06500155 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,0113894 0,06484066 ! carnitine metabolic process GO:0009437 5 5 0,000 0,0113894 0,06468056 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,0113894 0,06452125 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,0113894 0,06436272 GO:0055081|anion homeostasis, ! muscle cell differentiation GO:0042692 104 71 1,000 0,0114826 0,06473036 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,0114826 0,0645721 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,01179373 0,06615994 ! response to hypoxia GO:0001666 132 72 1,000 0,01179373 0,06599896 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,01179373 0,06583877 ! negative regulation of transport GO:0051051 116 73 1,000 0,01210855 0,06743258 ! response to oxygen levels GO:0070482 137 74 1,000 0,01242704 0,06903911 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,01242704 0,06887275 ! response to inorganic substance GO:0010035 115 75 1,000 0,01274919 0,07048832 ! response to unfolded protein GO:0006986 99 76 1,000 0,01307498 0,07211622 ! protein ubiquitination GO:0016567 125 77 1,000 0,0134044 0,07375626 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,0134044 0,07358024 ! tRNA transcription GO:0009304 11 6 0,000 0,01365206 0,07476127 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01365206 0,07458369 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01365206 0,07440695 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01365206 0,07423105 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01365206 0,07405597 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01365206 0,07388173 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01365206 0,07370829 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01365206 0,07353568 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01365206 0,07336386 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01365206 0,07319285 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01365206 0,07302264 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01365206 0,07285321 ! prostate gland development GO:0030850 9 6 0,000 0,01365206 0,07268457 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01365206 0,07251671 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01365206 0,07234962 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01365206 0,0721833 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01365206 0,07201774 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01365206 0,07185294 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01365206 0,07168889 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01365206 0,07152559 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01365206 0,07136303 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01365206 0,07120121 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01365206 0,07104012 ! neuron adhesion GO:0007158 9 6 0,000 0,01365206 0,07087976 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01365206 0,07072012 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01365206 0,0705612 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01365206 0,07040299 ! signal peptide processing GO:0006465 8 6 0,000 0,01365206 0,07024549 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01365206 0,07008869 ! mRNA stabilization GO:0048255 15 6 0,000 0,01365206 0,06993259 GO:0043489|RNA stabilization, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01365206 0,06977719 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01365206 0,06962247 ! opsonization GO:0008228 8 6 0,000 0,01365206 0,06946844 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01365206 0,06931508 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01365206 0,06916241 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01365206 0,0690104 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01365206 0,06885906 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01365206 0,06870839 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01365206 0,06855837 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01365206 0,06840901 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01365206 0,06826029 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01365206 0,06811222 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01365206 0,06796479 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01365206 0,067818 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01365206 0,06767184 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01365206 0,06752631 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01365206 0,0673814 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01365206 0,06723712 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01365206 0,06709345 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01365206 0,06695039 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01365206 0,06680794 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01365206 0,0666661 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01365206 0,06652486 ! thymic T cell selection GO:0045061 12 6 0,000 0,01365206 0,06638421 ! protein lipoylation GO:0009249 10 6 0,000 0,01365206 0,06624416 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01365206 0,0661047 ! pigment granule organization GO:0048753 11 6 0,000 0,01365206 0,06596583 ! drug transport GO:0015893 6 6 0,000 0,01365206 0,06582753 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01365206 0,06568982 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01365206 0,06555268 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01365206 0,06541611 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01365206 0,06528011 ! histidine metabolic process GO:0006547 6 6 0,000 0,01365206 0,06514468 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01365206 0,0650098 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01365206 0,06487548 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01365206 0,06474172 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01365206 0,0646085 ! adenohypophysis development GO:0021984 10 6 0,000 0,01365206 0,06447584 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01365206 0,06434372 ! hyperosmotic response GO:0006972 8 6 0,000 0,01365206 0,06421213 ! microtubule nucleation GO:0007020 10 6 0,000 0,01365206 0,06408109 ! ER overload response GO:0006983 7 6 0,000 0,01365206 0,06395058 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01365206 0,0638206 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01365206 0,06369114 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01365206 0,06356221 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01365206 0,0634338 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01365206 0,06330591 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01365206 0,06317854 ! response to dietary excess GO:0002021 7 6 0,000 0,01365206 0,06305167 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01365206 0,06292532 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01365206 0,06279947 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01365206 0,06267412 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01365206 0,06254927 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01365206 0,06242492 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01365206 0,06230106 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01365206 0,06217769 ! neuron apoptosis GO:0051402 8 6 0,000 0,01365206 0,06205481 ! organic alcohol transport GO:0015850 9 6 0,000 0,01365206 0,06193241 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01365206 0,0618105 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01365206 0,06168906 ! carnitine transport GO:0015879 8 6 0,000 0,01365206 0,0615681 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01365206 0,06144762 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01365206 0,0613276 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01365206 0,06120806 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01365206 0,06108898 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01365206 0,06097036 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01365206 0,0608522 ! parturition GO:0007567 12 6 0,000 0,01365206 0,06073449 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01365206 0,06061725 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01365206 0,06050045 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01365206 0,0603841 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01365206 0,0602682 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01365206 0,06015275 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01365206 0,06003773 ! astrocyte development GO:0014002 14 6 0,000 0,01365206 0,05992316 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01365206 0,05980902 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01365206 0,05969531 ! interaction with symbiont GO:0051702 8 6 0,000 0,01365206 0,05958204 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01365206 0,05946919 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01365206 0,05935677 ! eating behavior GO:0042755 6 6 0,000 0,01365206 0,05924478 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01365206 0,05913321 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01365206 0,05902206 ! response to copper ion GO:0046688 9 6 0,000 0,01365206 0,05891132 ! DNA topological change GO:0006265 8 6 0,000 0,01365206 0,058801 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01365206 0,05869109 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01365206 0,05858159 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01365206 0,0584725 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01365206 0,05836382 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01365206 0,05825553 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01365206 0,05814765 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01365206 0,05804017 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01365206 0,05793309 ! gas homeostasis GO:0033483 11 6 0,000 0,01365206 0,0578264 ! hair follicle maturation GO:0048820 7 6 0,000 0,01365206 0,0577201 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01365206 0,05761419 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01365206 0,05750867 ! Schwann cell development GO:0014044 14 6 0,000 0,01365206 0,05740353 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01365206 0,05729878 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01365206 0,05719441 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01365206 0,05709042 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01365206 0,05698681 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01365206 0,05688357 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01365206 0,05678071 ! histone ubiquitination GO:0016574 7 6 0,000 0,01365206 0,05667822 ! regulation of meiosis GO:0040020 10 6 0,000 0,01365206 0,0565761 GO:0051445|regulation of meiotic cell cycle, ! regulation of cell division GO:0051302 8 6 0,000 0,01365206 0,05647434 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01365206 0,05637295 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01365206 0,05627192 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01365206 0,05617126 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01365206 0,05607095 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01365206 0,055971 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01365206 0,05587141 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01365206 0,05577217 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01365206 0,05567329 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01365206 0,05557475 ! protein deubiquitination GO:0016579 8 6 0,000 0,01365206 0,05547656 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01365206 0,05537872 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01365206 0,05528122 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01365206 0,05518407 ! axonal fasciculation GO:0007413 9 6 0,000 0,01365206 0,05508725 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01365206 0,05499078 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01365206 0,05489464 ! midbrain development GO:0030901 6 6 0,000 0,01365206 0,05479884 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01365206 0,05470337 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01365206 0,05460823 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01365206 0,05451343 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01365206 0,05441895 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01365206 0,0543248 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01365206 0,05423097 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01365206 0,05413747 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01365206 0,05404429 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01365206 0,05395143 ! adult feeding behavior GO:0008343 6 6 0,000 0,01365206 0,05385889 ! blastocyst growth GO:0001832 15 6 0,000 0,01365206 0,05376667 ! pigment granule transport GO:0051904 12 6 0,000 0,01365206 0,05367476 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01365206 0,05358316 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01365206 0,05349188 ! catecholamine transport GO:0051937 7 6 0,000 0,01365206 0,05340091 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01365206 0,05331024 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01365206 0,05321989 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01365206 0,05312984 ! protein prenylation GO:0018342 10 6 0,000 0,01365206 0,05304009 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01365206 0,05295065 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01365206 0,0528615 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,01365206 0,05277266 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,01365206 0,05268412 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01365206 0,05259587 ! response to protein stimulus GO:0051789 111 81 1,000 0,01475795 0,05676133 ! regulation of neurological system process GO:0031644 122 81 1,000 0,01475795 0,05666657 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,01475795 0,05657213 GO:0002696|positive regulation of leukocyte activation, ! regulation of cell cycle process GO:0010564 122 81 1,000 0,01475795 0,056478 ! protein-DNA complex assembly GO:0065004 107 84 1,000 0,0158103 0,06040481 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,01590966 0,06068363 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01590966 0,06058316 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01590966 0,06048302 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01590966 0,06038321 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01590966 0,06028373 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01590966 0,06018458 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01590966 0,06008576 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01590966 0,05998726 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01590966 0,05988908 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01590966 0,05979122 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01590966 0,05969368 ! reproductive behavior GO:0019098 12 7 0,000 0,01590966 0,05959646 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01590966 0,05949956 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01590966 0,05940297 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,01590966 0,05930669 ! oligopeptide transport GO:0006857 11 7 0,000 0,01590966 0,05921072 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01590966 0,05911507 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01590966 0,05901972 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,01590966 0,05892468 ! RNA methylation GO:0001510 11 7 0,000 0,01590966 0,05882995 ! pericardium development GO:0060039 8 7 0,000 0,01590966 0,05873552 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01590966 0,05864139 ! fibril organization GO:0043206 13 7 0,000 0,01590966 0,05854756 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01590966 0,05845404 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01590966 0,05836081 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01590966 0,05826788 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01590966 0,05817524 ! lipoprotein transport GO:0042953 9 7 0,000 0,01590966 0,0580829 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01590966 0,05799085 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01590966 0,05789909 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01590966 0,05780762 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01590966 0,05771645 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01590966 0,05762555 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01590966 0,05753495 ! chemosensory behavior GO:0007635 9 7 0,000 0,01590966 0,05744463 ! microtubule bundle formation GO:0001578 8 7 0,000 0,01590966 0,05735459 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,01590966 0,05726483 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01590966 0,05717535 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01590966 0,05708616 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01590966 0,05699724 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01590966 0,05690859 ! reflex GO:0060004 12 7 0,000 0,01590966 0,05682023 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01590966 0,05673213 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01590966 0,05664431 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01590966 0,05655676 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01590966 0,05646949 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01590966 0,05638248 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01590966 0,05629573 ! spinal cord patterning GO:0021511 7 7 0,000 0,01590966 0,05620926 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01590966 0,05612305 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,01590966 0,0560371 ! adrenal gland development GO:0030325 17 7 0,000 0,01590966 0,05595142 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01590966 0,05586599 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01590966 0,05578083 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01590966 0,05569593 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01590966 0,05561129 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01590966 0,0555269 ! endosome organization GO:0007032 10 7 0,000 0,01590966 0,05544277 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01590966 0,05535889 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,01590966 0,05527527 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01590966 0,0551919 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01590966 0,05510877 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01590966 0,0550259 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01590966 0,05494328 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01590966 0,05486091 ! galactose metabolic process GO:0006012 10 7 0,000 0,01590966 0,05477878 ! vesicle fusion GO:0006906 15 7 0,000 0,01590966 0,0546969 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01590966 0,05461526 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01590966 0,05453387 ! organ growth GO:0035265 11 7 0,000 0,01590966 0,05445272 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,01590966 0,05437181 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,01590966 0,05429114 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01590966 0,05421071 ! retinol metabolic process GO:0042572 9 7 0,000 0,01590966 0,05413051 ! behavioral fear response GO:0001662 13 7 0,000 0,01590966 0,05405056 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,01590966 0,05397084 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01590966 0,05389135 ! rRNA modification GO:0000154 12 7 0,000 0,01590966 0,0538121 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01590966 0,05373308 ! response to UV-B GO:0010224 11 7 0,000 0,01590966 0,05365429 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01590966 0,05357573 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,01590966 0,05349741 ! intermediate filament organization GO:0045109 11 7 0,000 0,01590966 0,05341931 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,01590966 0,05334144 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01590966 0,05326379 ! fibrinolysis GO:0042730 9 7 0,000 0,01590966 0,05318638 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01590966 0,05310918 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01590966 0,05303221 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01590966 0,05295547 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01590966 0,05287894 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01590966 0,05280264 ! response to tropane GO:0014073 13 7 0,000 0,01590966 0,05272655 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01590966 0,05265069 ! melanosome localization GO:0032400 10 7 0,000 0,01590966 0,05257504 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01590966 0,05249961 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01590966 0,05242439 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,01590966 0,05234939 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01590966 0,05227461 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01590966 0,05220004 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01590966 0,05212568 ! mast cell activation GO:0045576 9 7 0,000 0,01590966 0,05205153 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01590966 0,05197759 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,01590966 0,05190387 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01590966 0,05183035 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01590966 0,05175704 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01590966 0,05168394 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01590966 0,05161104 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01590966 0,05153835 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01590966 0,05146586 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,01590966 0,05139358 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01590966 0,0513215 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01590966 0,05124962 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01590966 0,05117794 ! response to tumor cell GO:0002347 12 7 0,000 0,01590966 0,05110646 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01590966 0,05103518 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01590966 0,0509641 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01590966 0,05089322 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,01590966 0,05082254 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01590966 0,05075205 ! diuresis GO:0030146 12 7 0,000 0,01590966 0,05068175 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01590966 0,05061165 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01590966 0,05054175 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01590966 0,05047204 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01590966 0,05040252 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01590966 0,05033319 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01590966 0,05026405 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01590966 0,0501951 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01590966 0,05012634 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01590966 0,05005777 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01590966 0,04998938 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01590966 0,04992118 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01590966 0,04985317 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01590966 0,04978534 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01590966 0,0497177 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,01590966 0,04965024 ! ATP catabolic process GO:0006200 10 7 0,000 0,01590966 0,04958296 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01590966 0,04951587 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01590966 0,04944895 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01590966 0,04938222 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01590966 0,04931567 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01590966 0,0492493 ! muscle adaptation GO:0043500 12 7 0,000 0,01590966 0,0491831 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01590966 0,04911708 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01590966 0,04905124 ! retina homeostasis GO:0001895 9 7 0,000 0,01590966 0,04898558 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01590966 0,04892009 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,01590966 0,04885478 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01590966 0,04878964 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01590966 0,04872467 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01590966 0,04865988 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01590966 0,04859525 ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,01616808 0,04931908 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,01652933 0,05035424 ! interphase GO:0051325 159 88 1,000 0,01726216 0,05251715 ! reproductive developmental process GO:0003006 127 89 1,000 0,01763371 0,05357667 ! regulation of T cell activation GO:0050863 128 89 1,000 0,01763371 0,05350599 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,01800866 0,05457171 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,01816223 0,05496465 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,01816223 0,05489242 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,01816223 0,05482038 ! axon extension GO:0048675 11 8 0,000 0,01816223 0,05474853 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,01816223 0,05467687 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,01816223 0,0546054 ! associative learning GO:0008306 15 8 0,000 0,01816223 0,05453411 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,01816223 0,05446301 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,01816223 0,0543921 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,01816223 0,05432137 ! phosphate transport GO:0006817 10 8 0,000 0,01816223 0,05425082 ! N-glycan processing GO:0006491 12 8 0,000 0,01816223 0,05418046 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,01816223 0,05411027 ! UTP metabolic process GO:0046051 8 8 0,000 0,01816223 0,05404027 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,01816223 0,05397045 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,01816223 0,05390081 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,01816223 0,05383135 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,01816223 0,05376207 ! succinate metabolic process GO:0006105 14 8 0,000 0,01816223 0,05369297 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,01816223 0,05362405 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,01816223 0,0535553 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,01816223 0,05348672 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,01816223 0,05341833 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,01816223 0,0533501 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,01816223 0,05328206 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,01816223 0,05321418 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,01816223 0,05314648 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01816223 0,05307895 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,01816223 0,05301159 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,01816223 0,0529444 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,01816223 0,05287738 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,01816223 0,05281053 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,01816223 0,05274385 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,01816223 0,05267734 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,01816223 0,052611 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,01816223 0,05254482 ! astrocyte differentiation GO:0048708 16 8 0,000 0,01816223 0,05247881 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,01816223 0,05241296 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,01816223 0,05234728 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,01816223 0,05228177 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,01816223 0,05221641 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,01816223 0,05215123 ! melanin metabolic process GO:0006582 12 8 0,000 0,01816223 0,0520862 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,01816223 0,05202133 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,01816223 0,05195663 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,01816223 0,05189209 ! macrophage activation GO:0042116 12 8 0,000 0,01816223 0,05182771 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,01816223 0,05176348 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,01816223 0,05169942 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,01816223 0,05163551 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,01816223 0,05157177 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01816223 0,05150818 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,01816223 0,05144474 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,01816223 0,05138147 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,01816223 0,05131834 ! ruffle organization GO:0031529 11 8 0,000 0,01816223 0,05125538 ! osteoblast development GO:0002076 13 8 0,000 0,01816223 0,05119256 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,01816223 0,0511299 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,01816223 0,0510674 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,01816223 0,05100504 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,01816223 0,05094284 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,01816223 0,05088079 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,01816223 0,05081889 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,01816223 0,05075715 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,01816223 0,05069555 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,01816223 0,0506341 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,01816223 0,0505728 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,01816223 0,05051165 ! oligodendrocyte development GO:0014003 8 8 0,000 0,01816223 0,05045064 ! segment specification GO:0007379 10 8 0,000 0,01816223 0,05038978 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,01816223 0,05032907 ! cellular extravasation GO:0045123 11 8 0,000 0,01816223 0,05026851 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,01816223 0,05020809 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,01816223 0,05014782 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,01816223 0,05008769 ! snRNA metabolic process GO:0016073 10 8 0,000 0,01816223 0,0500277 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,01816223 0,04996786 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,01816223 0,04990816 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,01816223 0,04984861 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,01816223 0,04978919 ! nucleosome disassembly GO:0006337 12 8 0,000 0,01816223 0,04972992 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,01816223 0,04967079 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,01816223 0,04961179 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,01816223 0,04955294 ! icosanoid secretion GO:0032309 12 8 0,000 0,01816223 0,04949423 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,01816223 0,04943566 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,01816223 0,04937722 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,01816223 0,04931893 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,01816223 0,04926077 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,01816223 0,04920275 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,01816223 0,04914486 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,01816223 0,04908711 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,01816223 0,0490295 ! sterol catabolic process GO:0016127 9 8 0,000 0,01816223 0,04897202 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,01816223 0,04891467 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,01816223 0,04885746 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,01816223 0,04880039 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,01816223 0,04874344 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,01816223 0,04868663 ! prophase GO:0051324 11 8 0,000 0,01816223 0,04862995 ! S phase GO:0051320 8 8 0,000 0,01816223 0,04857341 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,01816223 0,04851699 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,01816223 0,04846071 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,01816223 0,04840456 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,01816223 0,04834853 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,01816223 0,04829264 ! hormone catabolic process GO:0042447 13 8 0,000 0,01816223 0,04823687 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,01816223 0,04818124 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,01816223 0,04812573 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,01816223 0,04807035 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,01816223 0,04801509 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,01816223 0,04795997 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,01816223 0,04790497 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,01816223 0,04785009 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,01816223 0,04779534 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,01816223 0,04774072 ! lamellipodium assembly GO:0030032 9 8 0,000 0,01816223 0,04768622 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,01816223 0,04763185 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,01816223 0,0475776 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,01816223 0,04752347 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,01876871 0,04905457 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,01915376 0,05000415 ! in utero embryonic development GO:0001701 147 96 1,000 0,02032887 0,05301181 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,02032887 0,05295177 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,02040977 0,05310234 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02040977 0,05304234 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,02040977 0,05298248 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02040977 0,05292274 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02040977 0,05286315 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,02040977 0,05280368 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02040977 0,05274435 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02040977 0,05268515 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02040977 0,05262609 ! GTP metabolic process GO:0046039 9 9 0,000 0,02040977 0,05256716 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02040977 0,05250836 ! social behavior GO:0035176 14 9 0,000 0,02040977 0,05244969 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02040977 0,05239115 ! artery development GO:0060840 19 9 0,000 0,02040977 0,05233275 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02040977 0,05227447 ! response to pain GO:0048265 16 9 0,000 0,02040977 0,05221632 ! protein complex disassembly GO:0043241 17 9 0,000 0,02040977 0,0521583 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02040977 0,05210041 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02040977 0,05204265 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02040977 0,05198502 ! lung alveolus development GO:0048286 17 9 0,000 0,02040977 0,05192751 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02040977 0,05187014 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02040977 0,05181288 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02040977 0,05175576 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02040977 0,05169876 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02040977 0,05164188 ! protein targeting to ER GO:0045047 19 9 0,000 0,02040977 0,05158514 ! T cell selection GO:0045058 18 9 0,000 0,02040977 0,05152851 ! endoderm development GO:0007492 12 9 0,000 0,02040977 0,05147201 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02040977 0,05141563 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02040977 0,05135938 ! arginine catabolic process GO:0006527 10 9 0,000 0,02040977 0,05130325 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02040977 0,05124724 ! L-serine metabolic process GO:0006563 13 9 0,000 0,02040977 0,05119136 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02040977 0,05113559 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02040977 0,05107995 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02040977 0,05102443 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02040977 0,05096903 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02040977 0,05091374 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02040977 0,05085858 ! mannose metabolic process GO:0006013 9 9 0,000 0,02040977 0,05080354 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02040977 0,05074862 ! receptor clustering GO:0043113 15 9 0,000 0,02040977 0,05069382 ! epithelial cell development GO:0002064 10 9 0,000 0,02040977 0,05063913 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02040977 0,05058456 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02040977 0,05053011 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02040977 0,05047578 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02040977 0,05042156 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02040977 0,05036746 ! motor axon guidance GO:0008045 14 9 0,000 0,02040977 0,05031348 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02040977 0,05025961 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02040977 0,05020585 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02040977 0,05015221 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02040977 0,05009869 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02040977 0,05004528 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02040977 0,04999198 ! DNA ligation GO:0006266 14 9 0,000 0,02040977 0,0499388 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02040977 0,04988573 ! response to amine stimulus GO:0014075 13 9 0,000 0,02040977 0,04983277 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02040977 0,04977993 ! erythrocyte development GO:0048821 11 9 0,000 0,02040977 0,0497272 ! renal water homeostasis GO:0003091 14 9 0,000 0,02040977 0,04967457 ! postreplication repair GO:0006301 11 9 0,000 0,02040977 0,04962206 ! mRNA cleavage GO:0006379 13 9 0,000 0,02040977 0,04956967 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02040977 0,04951738 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02040977 0,0494652 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02040977 0,04941313 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02040977 0,04936117 ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02040977 0,04930932 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02040977 0,04925758 ! acid secretion GO:0046717 14 9 0,000 0,02040977 0,04920595 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02040977 0,04915442 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02040977 0,04910301 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02040977 0,0490517 ! purine base metabolic process GO:0006144 18 9 0,000 0,02040977 0,04900049 ! oocyte differentiation GO:0009994 12 9 0,000 0,02040977 0,0489494 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02040977 0,04889841 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02040977 0,04884753 ! spleen development GO:0048536 15 9 0,000 0,02040977 0,04879675 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02040977 0,04874608 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02040977 0,04869551 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02040977 0,04864505 ! detection of calcium ion GO:0005513 13 9 0,000 0,02040977 0,04859469 ! blastocyst formation GO:0001825 12 9 0,000 0,02040977 0,04854444 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02040977 0,04849429 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02040977 0,04844424 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02040977 0,0483943 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02040977 0,04834446 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02040977 0,04829473 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02040977 0,04824509 ! prepulse inhibition GO:0060134 14 9 0,000 0,02040977 0,04819556 ! embryonic placenta development GO:0001892 12 9 0,000 0,02040977 0,04814613 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,02040977 0,0480968 ! insulin secretion GO:0030073 17 9 0,000 0,02040977 0,04804757 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02040977 0,04799844 ! response to nicotine GO:0035094 16 9 0,000 0,02040977 0,04794941 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02040977 0,04790048 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02040977 0,04785165 ! localization within membrane GO:0051668 15 9 0,000 0,02040977 0,04780293 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,02194161 0,05133846 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02265229 0,05294744 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02265229 0,05289368 ! neuron fate specification GO:0048665 11 10 0,000 0,02265229 0,05284004 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02265229 0,0527865 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02265229 0,05273307 ! thyroid gland development GO:0030878 19 10 0,000 0,02265229 0,05267975 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,02265229 0,05262654 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02265229 0,05257344 ! synapsis GO:0007129 13 10 0,000 0,02265229 0,05252044 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02265229 0,05246755 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02265229 0,05241477 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02265229 0,05236209 ! sulfate transport GO:0008272 12 10 0,000 0,02265229 0,05230951 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02265229 0,05225705 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,02265229 0,05220469 ! phospholipid efflux GO:0033700 16 10 0,000 0,02265229 0,05215243 ! hippocampus development GO:0021766 19 10 0,000 0,02265229 0,05210028 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,02265229 0,05204823 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02265229 0,05199628 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02265229 0,05194444 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02265229 0,05189271 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02265229 0,05184107 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02265229 0,05178954 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02265229 0,05173811 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02265229 0,05168678 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02265229 0,05163556 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02265229 0,05158443 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02265229 0,05153341 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02265229 0,05148249 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02265229 0,05143166 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02265229 0,05138094 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02265229 0,05133032 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02265229 0,0512798 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02265229 0,05122938 ! response to X-ray GO:0010165 16 10 0,000 0,02265229 0,05117905 ! B cell proliferation GO:0042100 14 10 0,000 0,02265229 0,05112883 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02265229 0,0510787 ! forebrain cell migration GO:0021885 17 10 0,000 0,02265229 0,05102867 ! lipid digestion GO:0044241 15 10 0,000 0,02265229 0,05097874 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02265229 0,05092891 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02265229 0,05087918 ! UV protection GO:0009650 14 10 0,000 0,02265229 0,05082954 ! entry into host cell GO:0030260 20 10 0,000 0,02265229 0,05078 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02265229 0,05073055 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02265229 0,0506812 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02265229 0,05063195 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02265229 0,05058279 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02265229 0,05053373 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02265229 0,05048476 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02265229 0,05043589 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02265229 0,05038711 ! regulation of organ growth GO:0046620 11 10 0,000 0,02265229 0,05033843 ! response to dsRNA GO:0043331 18 10 0,000 0,02265229 0,05028984 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02265229 0,05024135 ! embryonic axis specification GO:0000578 12 10 0,000 0,02265229 0,05019294 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02265229 0,05014464 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02265229 0,05009642 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02265229 0,0500483 ! cranial nerve development GO:0021545 12 10 0,000 0,02265229 0,05000027 ! fucose catabolic process GO:0019317 16 10 0,000 0,02265229 0,04995233 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02265229 0,04990448 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02265229 0,04985672 ! protein sumoylation GO:0016925 12 10 0,000 0,02265229 0,04980906 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02265229 0,04976149 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02265229 0,049714 ! zymogen activation GO:0031638 14 10 0,000 0,02265229 0,04966661 ! salivary gland development GO:0007431 22 10 0,000 0,02265229 0,04961931 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02265229 0,0495721 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02265229 0,04952498 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02265229 0,04947795 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02265229 0,049431 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02265229 0,04938415 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02265229 0,04933738 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02265229 0,04929071 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02265229 0,04924412 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02265229 0,04919762 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02265229 0,0491512 ! detection of bacterium GO:0016045 10 10 0,000 0,02265229 0,04910488 ! embryonic gut development GO:0048566 11 10 0,000 0,02265229 0,04905864 ! activation of innate immune response GO:0002218 10 10 0,000 0,02265229 0,04901249 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02265229 0,04896643 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02265229 0,04892045 ! developmental induction GO:0031128 13 10 0,000 0,02265229 0,04887456 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02265229 0,04882875 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02265229 0,04878303 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02265229 0,0487374 ! rRNA transcription GO:0009303 17 11 0,000 0,02488981 0,05350146 ! respiratory burst GO:0045730 14 11 0,000 0,02488981 0,05345151 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,02488981 0,05340165 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,02488981 0,05335188 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,02488981 0,0533022 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,02488981 0,05325262 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,02488981 0,05320313 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,02488981 0,05315373 ! RNA polyadenylation GO:0043631 19 11 0,000 0,02488981 0,05310442 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,02488981 0,05305521 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,02488981 0,05300608 ! mating GO:0007618 14 11 0,000 0,02488981 0,05295705 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,02488981 0,0529081 ! T cell proliferation GO:0042098 20 11 0,000 0,02488981 0,05285925 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,02488981 0,05281049 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,02488981 0,05276181 ! bone resorption GO:0045453 16 11 0,000 0,02488981 0,05271323 ! regulated secretory pathway GO:0045055 14 11 0,000 0,02488981 0,05266474 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,02488981 0,05261633 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,02488981 0,05256801 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,02488981 0,05251979 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,02488981 0,05247165 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,02488981 0,0524236 ! syncytium formation GO:0006949 15 11 0,000 0,02488981 0,05237563 ! plasma membrane organization GO:0007009 18 11 0,000 0,02488981 0,05232776 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,02488981 0,05227997 ! mitotic spindle organization GO:0007052 15 11 0,000 0,02488981 0,05223227 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,02488981 0,05218466 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,02488981 0,05213713 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,02488981 0,05208969 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,02488981 0,05204233 ! adult heart development GO:0007512 11 11 0,000 0,02488981 0,05199507 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,02488981 0,05194788 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,02488981 0,05190079 ! temperature homeostasis GO:0001659 16 11 0,000 0,02488981 0,05185377 ! L-glutamate transport GO:0015813 16 11 0,000 0,02488981 0,05180685 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,02488981 0,05176001 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,02488981 0,05171325 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,02488981 0,05166658 ! stem cell development GO:0048864 29 11 0,000 0,02488981 0,05161999 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,02488981 0,05157348 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,02488981 0,05152706 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,02488981 0,05148073 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,02488981 0,05143447 ! vasoconstriction GO:0042310 15 11 0,000 0,02488981 0,0513883 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,02488981 0,05134221 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,02488981 0,05129621 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,02488981 0,05125028 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,02488981 0,05120444 ! ribosome assembly GO:0042255 13 11 0,000 0,02488981 0,05115868 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,02488981 0,05111301 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,02488981 0,05106741 ! chromatin silencing GO:0006342 19 11 0,000 0,02488981 0,0510219 ! nucleosome positioning GO:0016584 13 11 0,000 0,02488981 0,05097646 ! T cell homeostasis GO:0043029 20 11 0,000 0,02488981 0,05093111 ! regulation of isotype switching GO:0045191 19 11 0,000 0,02488981 0,05088584 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,02488981 0,05084065 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,02488981 0,05079553 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,02488981 0,0507505 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,02488981 0,05070555 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,02488981 0,05066068 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,02488981 0,05061589 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,02488981 0,05057117 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,02488981 0,05052654 ! male genitalia development GO:0030539 13 11 0,000 0,02488981 0,05048198 ! cholesterol efflux GO:0033344 19 11 0,000 0,02488981 0,0504375 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,02488981 0,0503931 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,02488981 0,05034878 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,02488981 0,05030454 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,02488981 0,05026037 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,02488981 0,05021629 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,02488981 0,05017228 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,02488981 0,05012834 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,02488981 0,05008449 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,02488981 0,05004071 ! lysogeny GO:0030069 18 11 0,000 0,02488981 0,049997 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,02488981 0,04995337 ! acrosome reaction GO:0007340 13 11 0,000 0,02488981 0,04990982 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,02488981 0,04986635 ! lactation GO:0007595 20 12 0,000 0,02712233 0,05429188 ! reproductive cellular process GO:0048610 14 12 0,000 0,02712233 0,05424467 ! tRNA modification GO:0006400 14 12 0,000 0,02712233 0,05419754 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,02712233 0,05415049 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,02712233 0,05410353 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,02712233 0,05405665 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,02712233 0,05400984 ! non-recombinational repair GO:0000726 19 12 0,000 0,02712233 0,05396312 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,02712233 0,05391648 ! peroxisomal transport GO:0043574 21 12 0,000 0,02712233 0,05386992 ! cartilage condensation GO:0001502 18 12 0,000 0,02712233 0,05382344 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,02712233 0,05377704 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,02712233 0,05373072 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,02712233 0,05368448 ! heart looping GO:0001947 15 12 0,000 0,02712233 0,05363832 ! palate development GO:0060021 15 12 0,000 0,02712233 0,05359224 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,02712233 0,05354624 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,02712233 0,05350032 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,02712233 0,05345447 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,02712233 0,05340871 ! arginine metabolic process GO:0006525 13 12 0,000 0,02712233 0,05336302 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,02712233 0,05331741 ! methionine metabolic process GO:0006555 13 12 0,000 0,02712233 0,05327188 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,02712233 0,05322642 ! Golgi organization GO:0007030 18 12 0,000 0,02712233 0,05318105 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,02712233 0,05313575 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,02712233 0,05309053 ! monoamine transport GO:0015844 13 12 0,000 0,02712233 0,05304538 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02712233 0,05300031 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,02712233 0,05295532 ! L-amino acid transport GO:0015807 20 12 0,000 0,02712233 0,05291041 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,02712233 0,05286557 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,02712233 0,0528208 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,02712233 0,05277612 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,02712233 0,0527315 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,02712233 0,05268697 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,02712233 0,05264251 ! cerebellum development GO:0021549 13 12 0,000 0,02712233 0,05259812 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,02712233 0,05255381 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,02712233 0,05250957 ! histone acetylation GO:0016573 23 12 0,000 0,02712233 0,05246541 ! histone methylation GO:0016571 15 12 0,000 0,02712233 0,05242132 ! autonomic nervous system development GO:0048483 23 12 0,000 0,02712233 0,0523773 ! gland morphogenesis GO:0022612 23 12 0,000 0,02712233 0,05233336 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,02712233 0,0522895 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,02712233 0,0522457 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,02712233 0,05220198 ! response to gamma radiation GO:0010332 20 12 0,000 0,02712233 0,05215834 ! regulation of epidermis development GO:0045682 17 12 0,000 0,02712233 0,05211476 ! intestinal absorption GO:0050892 19 12 0,000 0,02712233 0,05207126 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,02712233 0,05202783 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,02712233 0,05198447 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,02712233 0,05194119 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,02712233 0,05189798 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,02712233 0,05185484 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,02712233 0,05181177 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,02712233 0,05176877 ! response to cold GO:0009409 14 12 0,000 0,02712233 0,05172585 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,02934987 0,05592768 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,02934987 0,05588138 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,02934987 0,05583516 ! cGMP metabolic process GO:0046068 16 13 0,000 0,02934987 0,05578902 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,02934987 0,05574295 ! water transport GO:0006833 17 13 0,000 0,02934987 0,05569695 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,02934987 0,05565104 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,02934987 0,0556052 ! lipid localization GO:0010876 24 13 0,000 0,02934987 0,05555943 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,02934987 0,05551374 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,02934987 0,05546813 ! organelle fusion GO:0048284 28 13 0,000 0,02934987 0,05542259 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,02934987 0,05537712 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,02934987 0,05533173 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,02934987 0,05528641 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,02934987 0,05524117 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,02934987 0,055196 ! response to hexose stimulus GO:0009746 19 13 0,000 0,02934987 0,05515091 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,02934987 0,05510589 ! glutamate metabolic process GO:0006536 18 13 0,000 0,02934987 0,05506094 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,02934987 0,05501606 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,02934987 0,05497126 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,02934987 0,05492653 ! NAD metabolic process GO:0019674 21 13 0,000 0,02934987 0,05488188 ! exocrine system development GO:0035272 27 13 0,000 0,02934987 0,05483729 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,02934987 0,05479278 ! bone mineralization GO:0030282 15 13 0,000 0,02934987 0,05474835 ! regulation of exocytosis GO:0017157 17 13 0,000 0,02934987 0,05470398 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,02934987 0,05465968 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,02934987 0,05461546 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,02934987 0,05457131 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,02934987 0,05452723 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,02934987 0,05448322 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,02934987 0,05443928 ! genitalia development GO:0048806 15 13 0,000 0,02934987 0,05439541 ! regulation of cellular pH GO:0030641 20 13 0,000 0,02934987 0,05435162 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,02934987 0,05430789 ! cellular pigmentation GO:0033059 24 13 0,000 0,02934987 0,05426424 ! tissue regeneration GO:0042246 21 13 0,000 0,02934987 0,05422065 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,02934987 0,05417713 ! cofactor transport GO:0051181 19 13 0,000 0,02934987 0,05413369 ! NADP metabolic process GO:0006739 18 13 0,000 0,02934987 0,05409031 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,02934987 0,05404701 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,02934987 0,05400377 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,02934987 0,0539606 ! gas transport GO:0015669 18 13 0,000 0,02934987 0,0539175 ! regulation of RNA stability GO:0043487 28 13 0,000 0,02934987 0,05387447 ! heme biosynthetic process GO:0006783 20 13 0,000 0,02934987 0,05383151 ! regulation of axon extension GO:0030516 23 13 0,000 0,02934987 0,05378861 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,02934987 0,05374579 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,02934987 0,05370303 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,02934987 0,05366034 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,02934987 0,05361772 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,02934987 0,05357517 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,02934987 0,05353268 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,03157244 0,0575409 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,03157244 0,05749534 ! superoxide anion generation GO:0042554 18 14 0,000 0,03157244 0,05744985 ! neuron maturation GO:0042551 21 14 0,000 0,03157244 0,05740444 ! regulation of S phase GO:0033261 18 14 0,000 0,03157244 0,05735909 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,03157244 0,05731382 ! myotube differentiation GO:0014902 21 14 0,000 0,03157244 0,05726862 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,03157244 0,05722349 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,03157244 0,05717843 ! inositol metabolic process GO:0006020 20 14 0,000 0,03157244 0,05713345 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,03157244 0,05708853 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,03157244 0,05704369 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,03157244 0,05699891 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,03157244 0,0569542 ! gene silencing by RNA GO:0031047 20 14 0,000 0,03157244 0,05690957 ! response to cAMP GO:0051591 19 14 0,000 0,03157244 0,056865 ! limbic system development GO:0021761 25 14 0,000 0,03157244 0,05682051 ! startle response GO:0001964 21 14 0,000 0,03157244 0,05677608 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,03157244 0,05673173 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,03157244 0,05668744 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,03157244 0,05664322 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,03157244 0,05659907 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,03157244 0,05655499 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,03157244 0,05651098 ! glycine metabolic process GO:0006544 22 14 0,000 0,03157244 0,05646704 ! pituitary gland development GO:0021983 23 14 0,000 0,03157244 0,05642316 ! cellular response to starvation GO:0009267 21 14 0,000 0,03157244 0,05637936 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,03157244 0,05633562 GO:0031114|regulation of microtubule depolymerization, ! regulation of heart rate GO:0002027 23 14 0,000 0,03157244 0,05629195 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,03157244 0,05624834 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,03157244 0,05620481 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,03157244 0,05616134 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,03157244 0,05611794 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,03157244 0,0560746 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,03157244 0,05603134 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,03157244 0,05598814 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,03157244 0,055945 ! axon cargo transport GO:0008088 27 14 0,000 0,03157244 0,05590193 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,03157244 0,05585893 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,03157244 0,055816 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,03157244 0,05577313 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,03157244 0,05573032 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03157244 0,05568759 ! mRNA splice site selection GO:0006376 26 14 0,000 0,03157244 0,05564491 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,03157244 0,05560231 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,03157244 0,05555976 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,03157244 0,05551729 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,03157244 0,05547487 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,03157244 0,05543253 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,03157244 0,05539024 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,03157244 0,05534803 ! muscle maintenance GO:0046716 19 14 0,000 0,03157244 0,05530587 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,03157244 0,05526378 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,03157244 0,05522176 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,03157244 0,0551798 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,03157244 0,0551379 ! cell killing GO:0001906 20 14 0,000 0,03157244 0,05509606 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,03157244 0,05505429 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,03157244 0,05501258 ! cilium assembly GO:0042384 20 14 0,000 0,03157244 0,05497094 ! peptide hormone secretion GO:0030072 23 14 0,000 0,03157244 0,05492936 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,03379004 0,05874308 ! positive regulation of cell size GO:0045793 20 15 0,000 0,03379004 0,05869872 ! metencephalon development GO:0022037 19 15 0,000 0,03379004 0,05865441 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,03379004 0,05861018 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,03379004 0,05856601 ! skin development GO:0043588 25 15 0,000 0,03379004 0,05852191 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,03379004 0,05847788 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,03379004 0,05843391 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,03379004 0,05839001 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,03379004 0,05834617 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,03379004 0,0583024 ! bile acid metabolic process GO:0008206 22 15 0,000 0,03379004 0,0582587 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,03379004 0,05821506 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,03379004 0,05817148 ! adult walking behavior GO:0007628 25 15 0,000 0,03379004 0,05812797 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,03379004 0,05808453 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,03379004 0,05804115 ! myoblast differentiation GO:0045445 27 15 0,000 0,03379004 0,05799784 ! centrosome cycle GO:0007098 16 15 0,000 0,03379004 0,05795459 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,03379004 0,0579114 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,03379004 0,05786828 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,03379004 0,05782522 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,03379004 0,05778223 ! cerebral cortex development GO:0021987 29 15 0,000 0,03379004 0,0577393 ! response to osmotic stress GO:0006970 22 15 0,000 0,03379004 0,05769644 ! vesicle coating GO:0006901 25 15 0,000 0,03379004 0,05765363 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,03379004 0,0576109 ! DNA integration GO:0015074 22 15 0,000 0,03379004 0,05756822 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,03379004 0,05752561 ! peptide secretion GO:0002790 27 15 0,000 0,03379004 0,05748306 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,03379004 0,05744058 ! regulation of vasodilation GO:0042312 24 15 0,000 0,03379004 0,05739815 ! neuron recognition GO:0008038 22 15 0,000 0,03379004 0,05735579 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,03379004 0,0573135 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,03379004 0,05727126 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,03379004 0,05722909 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,03379004 0,05718698 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,03379004 0,05714493 ! biomineral formation GO:0031214 18 15 0,000 0,03379004 0,05710294 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,03379004 0,05706101 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,03379004 0,05701915 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,03379004 0,05697735 ! dopamine metabolic process GO:0042417 30 15 0,000 0,03379004 0,0569356 ! organic cation transport GO:0015695 19 15 0,000 0,03379004 0,05689392 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,03379004 0,0568523 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,03379004 0,05681075 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,03379004 0,05676925 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,03379004 0,05672781 ! defense response to virus GO:0051607 27 15 0,000 0,03379004 0,05668643 ! peptide hormone processing GO:0016486 19 15 0,000 0,03379004 0,05664512 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,03379004 0,05660386 ! protein secretion GO:0009306 27 16 0,000 0,0360027 0,06026652 ! hormone secretion GO:0046879 25 16 0,000 0,0360027 0,06022269 ! bone remodeling GO:0046849 24 16 0,000 0,0360027 0,06017892 ! endothelial cell migration GO:0043542 22 16 0,000 0,0360027 0,06013522 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,0360027 0,06009158 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,0360027 0,06004801 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0360027 0,06000449 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,0360027 0,05996104 ! glial cell development GO:0021782 24 16 0,000 0,0360027 0,05991766 ! patterning of blood vessels GO:0001569 24 16 0,000 0,0360027 0,05987433 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,0360027 0,05983107 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,0360027 0,05978787 ! protein polyubiquitination GO:0000209 26 16 0,000 0,0360027 0,05974473 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,0360027 0,05970166 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,0360027 0,05965865 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,0360027 0,05961569 ! fructose metabolic process GO:0006000 20 16 0,000 0,0360027 0,05957281 ! regulation of protein binding GO:0043393 27 16 0,000 0,0360027 0,05952998 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,0360027 0,05948721 ! protein export from nucleus GO:0006611 24 16 0,000 0,0360027 0,05944451 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,0360027 0,05940187 ! DNA replication initiation GO:0006270 25 16 0,000 0,0360027 0,05935928 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,0360027 0,05931676 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,0360027 0,0592743 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,0360027 0,0592319 ! diencephalon development GO:0021536 25 16 0,000 0,0360027 0,05918956 ! oogenesis GO:0048477 23 16 0,000 0,0360027 0,05914729 ! neural crest cell migration GO:0001755 24 16 0,000 0,0360027 0,05910507 ! G1 phase GO:0051318 27 16 0,000 0,0360027 0,05906291 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,0360027 0,05902081 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,0360027 0,05897878 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,0360027 0,0589368 ! steroid catabolic process GO:0006706 22 16 0,000 0,0360027 0,05889488 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,0360027 0,05885302 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,0360027 0,05881122 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,0360027 0,05876948 ! sperm-egg recognition GO:0035036 16 16 0,000 0,0360027 0,0587278 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,0360027 0,05868618 ! nerve development GO:0021675 18 16 0,000 0,0360027 0,05864462 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,0360027 0,05860311 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,0360027 0,05856167 ! negative regulation of translation GO:0017148 22 16 0,000 0,0360027 0,05852028 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,03821041 0,06206493 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,03821041 0,06202113 ! negative regulation of defense response GO:0031348 19 17 0,000 0,03821041 0,06197739 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,03821041 0,06193371 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,03821041 0,0618901 ! glycerol metabolic process GO:0006071 20 17 0,000 0,03821041 0,06184654 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,03821041 0,06180305 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,03821041 0,06175962 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,03821041 0,06171625 ! signal complex assembly GO:0007172 29 17 0,000 0,03821041 0,06167294 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,03821041 0,06162969 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,03821041 0,0615865 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,03821041 0,06154337 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,03821041 0,06150031 ! memory GO:0007613 25 17 0,000 0,03821041 0,0614573 ! keratinization GO:0031424 17 17 0,000 0,03821041 0,06141435 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,03821041 0,06137146 ! retinoid metabolic process GO:0001523 22 17 0,000 0,03821041 0,06132864 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,03821041 0,06128587 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,03821041 0,06124316 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,03821041 0,06120051 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,03821041 0,06115792 GO:0032392|DNA geometric change, ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,03821041 0,06111539 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,03821041 0,06107292 ! membrane budding GO:0006900 29 17 0,000 0,03821041 0,06103051 ! heme metabolic process GO:0042168 27 17 0,000 0,03821041 0,06098816 ! neuromuscular junction development GO:0007528 23 17 0,000 0,03821041 0,06094586 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,03821041 0,06090363 ! body fluid secretion GO:0007589 27 17 0,000 0,03821041 0,06086145 ! stem cell differentiation GO:0048863 36 17 0,000 0,03821041 0,06081933 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,03821041 0,06077727 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,03821041 0,06073527 ! sensory perception of pain GO:0019233 23 17 0,000 0,03821041 0,06069333 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,03821041 0,06065144 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,03821041 0,06060961 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,03821041 0,06056784 ! synaptogenesis GO:0007416 24 17 0,000 0,03821041 0,06052613 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,03821041 0,06048447 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,03821041 0,06044287 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,03821041 0,06040133 ! cell-cell junction organization GO:0045216 25 17 0,000 0,03821041 0,06035985 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,03821041 0,06031842 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,03821041 0,06027705 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,03821041 0,06023573 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,03821041 0,06019448 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,03821041 0,06015328 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,04041319 0,06357752 ! positive regulation of translation GO:0045727 28 18 0,000 0,04041319 0,06353406 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,04041319 0,06349067 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,04041319 0,06344733 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,04041319 0,06340405 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,04041319 0,06336083 ! cAMP metabolic process GO:0046058 33 18 0,000 0,04041319 0,06331767 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,04041319 0,06327456 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,04041319 0,06323152 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,04041319 0,06318854 ! axis specification GO:0009798 26 18 0,000 0,04041319 0,06314561 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,04041319 0,06310274 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,04041319 0,06305993 ! pancreas development GO:0031016 26 18 0,000 0,04041319 0,06301718 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,04041319 0,06297448 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,04041319 0,06293185 ! glutamine metabolic process GO:0006541 23 18 0,000 0,04041319 0,06288927 ! response to retinoic acid GO:0032526 25 18 0,000 0,04041319 0,06284674 ! pigmentation during development GO:0048066 31 18 0,000 0,04041319 0,06280428 ! central nervous system neuron development GO:0021954 30 18 0,000 0,04041319 0,06276187 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,04041319 0,06271952 ! fucose metabolic process GO:0006004 26 18 0,000 0,04041319 0,06267723 ! response to fungus GO:0009620 19 18 0,000 0,04041319 0,062635 ! peptide cross-linking GO:0018149 31 18 0,000 0,04041319 0,06259282 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,04041319 0,0625507 ! heart process GO:0003015 27 18 0,000 0,04041319 0,06250863 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,04041319 0,06246662 GO:0006692|prostanoid metabolic process, ! somitogenesis GO:0001756 24 18 0,000 0,04041319 0,06242467 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,04041319 0,06238278 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,04041319 0,06234094 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,04041319 0,06229915 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,04041319 0,06225742 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,04041319 0,06221575 ! vitamin transport GO:0051180 24 18 0,000 0,04041319 0,06217414 ! hormone transport GO:0009914 27 18 0,000 0,04041319 0,06213258 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,04041319 0,06209107 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,04041319 0,06204962 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,04041319 0,06200823 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,04041319 0,06196689 ! cell-cell recognition GO:0009988 20 18 0,000 0,04041319 0,06192561 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,04041319 0,06188438 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,04041319 0,0618432 ! regulation of glucose import GO:0046324 21 18 0,000 0,04041319 0,06180208 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,04041319 0,06176102 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,04041319 0,06172001 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,04041319 0,06167905 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,04261105 0,06499033 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,04261105 0,06494726 ! positive regulation of ossification GO:0045778 30 19 0,000 0,04261105 0,06490425 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,04261105 0,0648613 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,04261105 0,0648184 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,04261105 0,06477556 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,04261105 0,06473277 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,04261105 0,06469005 ! regeneration GO:0031099 32 19 0,000 0,04261105 0,06464737 ! response to alkaloid GO:0043279 32 19 0,000 0,04261105 0,06460476 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,04261105 0,0645622 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,04261105 0,0645197 ! smooth muscle contraction GO:0006939 36 19 0,000 0,04261105 0,06447725 ! peroxisome organization GO:0007031 29 19 0,000 0,04261105 0,06443486 ! digestive system process GO:0022600 30 19 0,000 0,04261105 0,06439252 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,04261105 0,06435024 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,04261105 0,06430802 ! response to vitamin A GO:0033189 26 19 0,000 0,04261105 0,06426585 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,04261105 0,06422373 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,04261105 0,06418168 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,04261105 0,06413967 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,04261105 0,06409772 ! response to starvation GO:0042594 30 19 0,000 0,04261105 0,06405583 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,04261105 0,06401399 ! plasma membrane fusion GO:0045026 23 19 0,000 0,04261105 0,06397221 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,04261105 0,06393048 ! cytolysis GO:0019835 20 19 0,000 0,04261105 0,0638888 ! renal system process GO:0003014 35 19 0,000 0,04261105 0,06384718 ! vasodilation GO:0042311 33 19 0,000 0,04261105 0,06380561 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,04261105 0,0637641 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,04261105 0,06372264 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,04261105 0,06368123 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,04261105 0,06363988 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,04261105 0,06359858 ! sarcomere organization GO:0045214 23 19 0,000 0,04261105 0,06355734 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,04261105 0,06351615 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,04261105 0,06347501 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,04261105 0,06343393 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,04261105 0,0633929 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,04261105 0,06335192 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,04261105 0,06331099 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,04261105 0,06327012 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,04261105 0,0632293 ! protein stabilization GO:0050821 26 19 0,000 0,04261105 0,06318854 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,04480401 0,06639769 ! iron ion transport GO:0006826 37 20 0,000 0,04480401 0,06635493 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,04480401 0,06631224 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,04480401 0,06626959 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,04480401 0,066227 ! response to vitamin GO:0033273 29 20 0,000 0,04480401 0,06618447 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,04480401 0,06614199 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,04480401 0,06609956 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,04480401 0,06605719 ! spinal cord development GO:0021510 31 20 0,000 0,04480401 0,06601487 ! response to ethanol GO:0045471 37 20 0,000 0,04480401 0,06597261 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,04480401 0,0659304 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,04480401 0,06588824 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,04480401 0,06584614 ! chromosome condensation GO:0030261 31 20 0,000 0,04480401 0,0658041 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,04480401 0,0657621 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,04480401 0,06572016 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,04480401 0,06567828 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,04480401 0,06563644 ! pallium development GO:0021543 38 20 0,000 0,04480401 0,06559466 ! DNA modification GO:0006304 28 20 0,000 0,04480401 0,06555293 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,04480401 0,06551126 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,04480401 0,06546964 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,04480401 0,06542807 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,04480401 0,06538656 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,04480401 0,06534509 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,04480401 0,06530368 ! collagen catabolic process GO:0030574 25 20 0,000 0,04480401 0,06526233 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,04480401 0,06522102 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,04480401 0,06517977 ! alditol metabolic process GO:0019400 24 20 0,000 0,04480401 0,06513857 ! actin filament-based movement GO:0030048 34 20 0,000 0,04480401 0,06509742 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,04699206 0,06823342 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,04699206 0,06819037 GO:0016444|somatic cell DNA recombination, ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,04699206 0,06814738 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,04699206 0,06810444 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,04699206 0,06806155 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,04699206 0,06801872 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,04699206 0,06797594 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,04699206 0,06793321 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,04699206 0,06789054 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,04699206 0,06784792 ! protein amino acid acylation GO:0043543 37 21 0,000 0,04699206 0,06780536 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,04699206 0,06776285 ! vesicle docking GO:0048278 27 21 0,000 0,04699206 0,06772039 ! phototransduction GO:0007602 25 21 0,000 0,04699206 0,06767799 ! dendrite development GO:0016358 35 21 0,000 0,04699206 0,06763563 ! ovarian follicle development GO:0001541 30 21 0,000 0,04699206 0,06759334 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,04699206 0,06755109 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,04699206 0,0675089 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,04699206 0,06746676 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,04699206 0,06742467 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,04699206 0,06738263 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,04699206 0,06734065 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,04699206 0,06729872 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,04699206 0,06725684 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,04699206 0,06721501 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,04699206 0,06717324 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,04699206 0,06713152 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,04699206 0,06708985 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,04699206 0,06704823 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,04699206 0,06700666 ! fatty acid transport GO:0015908 30 21 0,000 0,04699206 0,06696514 ! immunoglobulin production GO:0002377 33 21 0,000 0,04699206 0,06692368 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,04699206 0,06688227 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,04699206 0,0668409 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,04699206 0,06679959 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,04699206 0,06675833 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,04699206 0,06671713 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,04699206 0,06667597 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,04699206 0,06663486 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,04699206 0,0665938 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,04699206 0,0665528 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,04699206 0,06651184 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,04699206 0,06647094 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,04699206 0,06643008 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,04699206 0,06638928 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,04699206 0,06634852 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,04699206 0,06630782 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,04917523 0,06934582 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,04917523 0,06930333 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,04917523 0,06926089 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,04917523 0,0692185 ! viral genome replication GO:0019079 29 22 0,000 0,04917523 0,06917617 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,04917523 0,06913388 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,04917523 0,06909165 ! leukocyte adhesion GO:0007159 38 22 0,000 0,04917523 0,06904947 ! molting cycle process GO:0022404 40 22 0,000 0,04917523 0,06900734 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,04917523 0,06896526 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,04917523 0,06892324 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,04917523 0,06888126 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,04917523 0,06883934 ! vasculogenesis GO:0001570 33 22 0,000 0,04917523 0,06879746 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,04917523 0,06875564 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,04917523 0,06871387 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,04917523 0,06867215 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,04917523 0,06863048 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,04917523 0,06858886 ! lysosome organization GO:0007040 37 22 0,000 0,04917523 0,06854729 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,04917523 0,06850577 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,04917523 0,06846431 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,04917523 0,06842289 ! regulation of behavior GO:0050795 38 22 0,000 0,04917523 0,06838152 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,04917523 0,0683402 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,04917523 0,06829893 ! membrane depolarization GO:0051899 35 22 0,000 0,04917523 0,06825771 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,04917523 0,06821655 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,04917523 0,06817543 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,04917523 0,06813436 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,04917523 0,06809334 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,04917523 0,06805237 ! blastocyst development GO:0001824 37 22 0,000 0,04917523 0,06801144 ! neural tube closure GO:0001843 33 22 0,000 0,04917523 0,06797057 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,04917523 0,06792975 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,05135352 0,07089622 ! neuron fate commitment GO:0048663 32 23 0,000 0,05135352 0,07085369 ! embryonic pattern specification GO:0009880 31 23 0,000 0,05135352 0,07081121 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,05135352 0,07076879 ! myelination GO:0042552 35 23 0,000 0,05135352 0,07072641 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,05135352 0,07068408 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,05135352 0,07064181 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,05135352 0,07059958 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,05135352 0,07055741 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,05135352 0,07051529 ! vesicle targeting GO:0006903 32 23 0,000 0,05135352 0,07047321 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,05135352 0,07043119 ! osteoblast differentiation GO:0001649 40 23 0,000 0,05135352 0,07038922 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,05135352 0,07034729 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,05135352 0,07030542 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,05135352 0,0702636 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,05135352 0,07022182 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,05135352 0,0701801 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,05135352 0,07013842 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,05135352 0,0700968 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,05135352 0,07005522 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,05135352 0,0700137 ! cell fate determination GO:0001709 45 23 0,000 0,05135352 0,06997222 ! pentose metabolic process GO:0019321 31 23 0,000 0,05135352 0,06993079 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,05135352 0,06988941 ! spermatid development GO:0007286 33 23 0,000 0,05135352 0,06984808 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,05135352 0,0698068 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,05135352 0,06976557 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,05135352 0,06972438 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,05135352 0,06968325 ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,05135352 0,06964216 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,05135352 0,06960112 ! regulation of amine transport GO:0051952 38 23 0,000 0,05135352 0,06956013 ! liver development GO:0001889 40 23 0,000 0,05135352 0,06951919 ! initiation of viral infection GO:0019059 42 24 0,000 0,05352695 0,07241882 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,05352695 0,07237624 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,05352695 0,07233372 ! superoxide metabolic process GO:0006801 32 24 0,000 0,05352695 0,07229124 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,05352695 0,07224882 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,05352695 0,07220644 ! fat cell differentiation GO:0045444 37 24 0,000 0,05352695 0,07216412 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,05352695 0,07212184 ! sperm motility GO:0030317 27 24 0,000 0,05352695 0,07207962 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,05352695 0,07203744 ! vacuole organization GO:0007033 39 24 0,000 0,05352695 0,07199531 ! neural crest cell development GO:0014032 39 24 0,000 0,05352695 0,07195324 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,05352695 0,07191121 ! primary neural tube formation GO:0014020 35 24 0,000 0,05352695 0,07186923 ! negative regulation of cell development GO:0010721 56 24 0,000 0,05352695 0,0718273 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,05352695 0,07178542 ! base-excision repair GO:0006284 31 24 0,000 0,05352695 0,07174358 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,05352695 0,0717018 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,05352695 0,07166006 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,05352695 0,07161838 ! glutathione metabolic process GO:0006749 29 24 0,000 0,05352695 0,07157674 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,05352695 0,07153515 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,05352695 0,0714936 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,05352695 0,07145211 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,05569552 0,07430377 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,05569552 0,0742607 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,05569552 0,07421767 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,05569552 0,0741747 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,05569552 0,07413177 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,05569552 0,0740889 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,05569552 0,07404607 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,05569552 0,07400329 ! peptide transport GO:0015833 43 25 0,000 0,05569552 0,07396057 ! male gonad development GO:0008584 33 25 0,000 0,05569552 0,07391789 ! iron ion homeostasis GO:0055072 39 25 0,000 0,05569552 0,07387526 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,05569552 0,07383268 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,05569552 0,07379015 ! phospholipid transport GO:0015914 35 25 0,000 0,05569552 0,07374767 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,05569552 0,07370524 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,05569552 0,07366285 ! detection of light stimulus GO:0009583 30 25 0,000 0,05569552 0,07362052 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,05569552 0,07357823 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,05569552 0,07353599 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,05569552 0,0734938 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,05785925 0,0763052 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,05785925 0,07626147 ! translational initiation GO:0006413 43 26 0,000 0,05785925 0,0762178 ! regulation of pH GO:0006885 36 26 0,000 0,05785925 0,07617417 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,05785925 0,07613059 ! circadian rhythm GO:0007623 42 26 0,000 0,05785925 0,07608706 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,05785925 0,07604358 ! post-embryonic development GO:0009791 42 26 0,000 0,05785925 0,07600016 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,05785925 0,07595678 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,05785925 0,07591345 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,05785925 0,07587017 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,05785925 0,07582694 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,05785925 0,07578375 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,05785925 0,07574062 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,05785925 0,07569754 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,05785925 0,0756545 ! regulation of coagulation GO:0050818 39 26 0,000 0,05785925 0,07561152 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,06001814 0,07838826 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,06001814 0,07834377 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,06001814 0,07829933 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,06001814 0,07825495 ! membrane docking GO:0022406 39 27 0,000 0,06001814 0,07821061 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,06001814 0,07816632 ! catechol metabolic process GO:0009712 43 27 0,000 0,06001814 0,07812209 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,06001814 0,0780779 ! acute-phase response GO:0006953 42 27 0,000 0,06001814 0,07803376 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,06001814 0,07798968 ! myofibril assembly GO:0030239 36 27 0,000 0,06001814 0,07794564 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,06001814 0,07790165 ! response to ionizing radiation GO:0010212 47 27 0,000 0,06001814 0,07785771 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,06001814 0,07781383 ! natural killer cell activation GO:0030101 35 27 0,000 0,06001814 0,07776999 ! lipid oxidation GO:0034440 38 27 0,000 0,06001814 0,0777262 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,06001814 0,07768246 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,06001814 0,07763877 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,06001814 0,07759512 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,06001814 0,07755153 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,06001814 0,07750799 ! gene silencing GO:0016458 41 27 0,000 0,06001814 0,07746449 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,06217221 0,08019971 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,06217221 0,08015476 ! phenol metabolic process GO:0018958 44 28 0,000 0,06217221 0,08010985 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,06217221 0,080065 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,06217221 0,08002019 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,06217221 0,07997544 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,06217221 0,07993074 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,06217221 0,07988608 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,06217221 0,07984148 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,06217221 0,07979692 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,06217221 0,07975242 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,06217221 0,07970796 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,06217221 0,07966356 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,06217221 0,0796192 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,06217221 0,07957489 ! mesoderm formation GO:0001707 46 28 0,000 0,06217221 0,07953064 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,06217221 0,07948643 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,06217221 0,07944227 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,06217221 0,07939816 ! ensheathment of neurons GO:0007272 43 28 0,000 0,06217221 0,0793541 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,06217221 0,07931009 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,06217221 0,07926612 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,06217221 0,07922221 ! neural tube formation GO:0001841 41 28 0,000 0,06217221 0,07917834 ! placenta development GO:0001890 37 28 0,000 0,06217221 0,07913452 ! regulation of B cell activation GO:0050864 42 28 0,000 0,06217221 0,07909076 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,06432147 0,08177964 ! regulation of innate immune response GO:0045088 38 29 0,000 0,06432147 0,08173446 ! ovulation cycle process GO:0022602 41 29 0,000 0,06432147 0,08168933 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,06432147 0,08164425 ! protein targeting to membrane GO:0006612 53 29 0,000 0,06432147 0,08159921 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,06432147 0,08155423 ! mismatch repair GO:0006298 34 29 0,000 0,06432147 0,0815093 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,06432147 0,08146441 ! muscle cell development GO:0055001 38 29 0,000 0,06432147 0,08141958 ! formation of primary germ layer GO:0001704 48 29 0,000 0,06432147 0,08137479 ! telencephalon development GO:0021537 52 29 0,000 0,06432147 0,08133006 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,06432147 0,08128537 ! eye morphogenesis GO:0048592 51 29 0,000 0,06432147 0,08124073 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,06432147 0,08119614 ! tissue homeostasis GO:0001894 42 29 0,000 0,06432147 0,0811516 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,06646592 0,08381119 ! collagen metabolic process GO:0032963 40 30 0,000 0,06646592 0,08376527 ! organic anion transport GO:0015711 51 30 0,000 0,06646592 0,0837194 ! cholesterol transport GO:0030301 46 30 0,000 0,06646592 0,08367357 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,06646592 0,0836278 ! spliceosome assembly GO:0000245 49 30 0,000 0,06646592 0,08358208 ! spindle organization GO:0007051 37 30 0,000 0,06646592 0,0835364 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,06646592 0,08349078 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,06646592 0,08344521 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,06646592 0,08339968 ! ceramide metabolic process GO:0006672 43 30 0,000 0,06646592 0,08335421 ! ovulation cycle GO:0042698 43 30 0,000 0,06646592 0,08330878 ! hindbrain development GO:0030902 45 30 0,000 0,06646592 0,08326341 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,06646592 0,08321808 ! adult locomotory behavior GO:0008344 47 30 0,000 0,06646592 0,08317281 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,06646592 0,08312758 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,06646592 0,0830824 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,06646592 0,08303727 ! response to heat GO:0009408 41 30 0,000 0,06646592 0,08299219 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,06646592 0,08294716 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,06646592 0,08290218 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,06860558 0,08552457 ! negative regulation of secretion GO:0051048 49 31 0,000 0,06860558 0,08547824 ! mammary gland development GO:0030879 57 31 0,000 0,06860558 0,08543196 ! glial cell differentiation GO:0010001 55 31 0,000 0,06860558 0,08538573 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,06860558 0,08533955 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,06860558 0,08529342 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,06860558 0,08524735 ! odontogenesis GO:0042476 50 31 0,000 0,06860558 0,08520132 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,06860558 0,08515534 ! segmentation GO:0035282 41 31 0,000 0,06860558 0,0851094 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,06860558 0,08506352 ! metanephros development GO:0001656 58 31 0,000 0,06860558 0,08501769 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,06860558 0,08497191 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,06860558 0,08492618 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,06860558 0,08488049 ! cell fate specification GO:0001708 37 31 0,000 0,06860558 0,08483486 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,06860558 0,08478927 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,06860558 0,08474374 ! RNA modification GO:0009451 40 31 0,000 0,06860558 0,08469825 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,07074046 0,08728705 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,07074046 0,08724025 ! meiosis I GO:0007127 52 32 0,000 0,07074046 0,08719349 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,07074046 0,08714679 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,07074046 0,08710014 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,07074046 0,08705354 ! peripheral nervous system development GO:0007422 53 32 0,000 0,07074046 0,08700698 ! regulation of protein stability GO:0031647 48 32 0,000 0,07074046 0,08696048 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,07074046 0,08691403 ! cytokine production GO:0001816 44 32 0,000 0,07074046 0,08686762 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,07074046 0,08682127 ! vesicle localization GO:0051648 47 32 0,000 0,07074046 0,08677496 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,07287057 0,08934025 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,07287057 0,08929265 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,07287057 0,0892451 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,07287057 0,08919761 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,07287057 0,08915016 ! sister chromatid segregation GO:0000819 46 33 0,000 0,07287057 0,08910277 ! ear morphogenesis GO:0042471 42 33 0,000 0,07287057 0,08905542 ! actomyosin structure organization GO:0031032 43 33 0,000 0,07287057 0,08900813 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,07287057 0,08896088 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,07287057 0,08891369 ! nucleus organization GO:0006997 49 33 0,000 0,07287057 0,08886655 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,07287057 0,08881945 ! female gonad development GO:0008585 49 33 0,000 0,07287057 0,08877241 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,07287057 0,08872541 ! positive regulation of cell development GO:0010720 54 33 0,000 0,07287057 0,08867847 ! lipid homeostasis GO:0055088 55 33 0,000 0,07287057 0,08863157 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,07287057 0,08858473 ! regulation of proteolysis GO:0030162 50 33 0,000 0,07287057 0,08853793 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,07287057 0,08849119 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,07287057 0,08844449 ! cytokinesis GO:0000910 52 33 0,000 0,07287057 0,08839784 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,07287057 0,08835124 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,07499591 0,09088019 ! mRNA catabolic process GO:0006402 48 34 0,000 0,07499591 0,09083233 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,07499591 0,09078453 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,07499591 0,09073677 ! feeding behavior GO:0007631 45 34 0,000 0,07499591 0,09068907 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,07499591 0,09064141 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,07499591 0,0905938 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,07499591 0,09054625 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,07499591 0,09049874 ! neuron migration GO:0001764 46 34 0,000 0,07499591 0,09045129 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,07499591 0,09040388 ! female gamete generation GO:0007292 43 34 0,000 0,07499591 0,09035652 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,07499591 0,09030922 ! polyol metabolic process GO:0019751 44 34 0,000 0,07499591 0,09026196 ! aerobic respiration GO:0009060 47 34 0,000 0,07499591 0,09021475 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,07499591 0,09016759 ! embryonic organ development GO:0048568 45 34 0,000 0,07499591 0,09012048 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,07499591 0,09007342 ! Notch signaling pathway GO:0007219 56 35 0,000 0,07711651 0,09257201 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,07711651 0,09252372 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,07711651 0,09247548 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,07711651 0,09242729 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,07711651 0,09237915 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,07711651 0,09233106 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,07711651 0,09228303 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,07711651 0,09223504 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,07711651 0,0921871 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,07711651 0,09213921 ! glycogen metabolic process GO:0005977 48 35 0,000 0,07711651 0,09209137 ! pigment metabolic process GO:0042440 61 35 0,000 0,07711651 0,09204358 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,07711651 0,09199584 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,07711651 0,09194815 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,07923237 0,09442199 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,07923237 0,09437309 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,07923237 0,09432425 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,07923237 0,09427545 ! negative regulation of binding GO:0051100 58 36 0,000 0,07923237 0,0942267 ! organic ether metabolic process GO:0018904 46 36 0,000 0,07923237 0,09417801 ! tissue remodeling GO:0048771 62 36 0,000 0,07923237 0,09412936 ! neural tube development GO:0021915 50 36 0,000 0,07923237 0,09408077 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,07923237 0,09403222 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,07923237 0,09398373 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,07923237 0,09393528 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,07923237 0,09388689 ! glucan metabolic process GO:0044042 49 36 0,000 0,07923237 0,09383854 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,08134349 0,09628926 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,08134349 0,09623973 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,08134349 0,09619025 ! ion transmembrane transport GO:0034220 56 37 0,000 0,08134349 0,09614082 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,08134349 0,09609144 ! regulation of protein secretion GO:0050708 51 37 0,000 0,08134349 0,09604211 ! amino acid activation GO:0043038 52 37 0,000 0,08134349 0,09599283 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,08134349 0,09594361 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,0834499 0,09837764 ! gliogenesis GO:0042063 71 38 0,000 0,0834499 0,09832724 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,0834499 0,09827689 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,0834499 0,0982266 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,0834499 0,09817635 ! phagocytosis GO:0006909 60 38 0,000 0,0834499 0,09812616 ! mesenchymal cell development GO:0014031 64 38 0,000 0,0834499 0,09807602 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,0834499 0,09802593 ! maintenance of location in cell GO:0051651 69 38 0,000 0,0834499 0,09797589 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,0855516 0,10039218 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,0855516 0,10034099 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,0855516 0,10028984 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,0855516 0,10023875 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,0855516 0,10018772 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,0855516 0,10013673 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,0855516 0,10008579 ! male sex differentiation GO:0046661 53 39 0,000 0,0855516 0,10003491 ! chromatin remodeling GO:0006338 68 39 0,000 0,0855516 0,09998408 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,0855516 0,0999333 ! JNK cascade GO:0007254 54 39 0,000 0,0855516 0,09988257 ! developmental growth GO:0048589 62 39 0,000 0,0855516 0,0998319 ! synapse organization GO:0050808 55 39 0,000 0,0855516 0,09978127 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,08764859 0,10217525 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,08764859 0,10212349 ! regulation of tube size GO:0035150 60 40 0,000 0,08764859 0,10207178 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,08764859 0,10202013 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,08764859 0,10196852 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,08764859 0,10191697 ! peptide metabolic process GO:0006518 56 40 0,000 0,08764859 0,10186547 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,08764859 0,10181402 ! inner ear development GO:0048839 57 40 0,000 0,08764859 0,10176263 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,08764859 0,10171129 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,08764859 0,10165999 ! B cell differentiation GO:0030183 62 40 0,000 0,08764859 0,10160875 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,08764859 0,10155757 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,08764859 0,10150643 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,08764859 0,10145534 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,08764859 0,10140431 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,0897409 0,10377279 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,0897409 0,10372064 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,0897409 0,10366855 ! endosome transport GO:0016197 71 41 0,000 0,0897409 0,10361651 ! striated muscle contraction GO:0006941 62 41 0,000 0,0897409 0,10356452 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,0897409 0,10351258 ! biopolymer methylation GO:0043414 62 41 0,000 0,0897409 0,10346069 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,0897409 0,10340886 ! mitochondrial transport GO:0006839 60 42 0,000 0,09182853 0,10576146 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,09182853 0,10570852 ! cellular component disassembly GO:0022411 64 42 0,000 0,09182853 0,10565564 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,09182853 0,10560281 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,09182853 0,10555004 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,09182853 0,10549732 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,09182853 0,10544465 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,09182853 0,10539203 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,09182853 0,10533947 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,09182853 0,10528695 ! regulation of cell shape GO:0008360 78 42 0,000 0,09182853 0,10523449 ! positive regulation of binding GO:0051099 59 43 0,000 0,0939115 0,10756795 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 0,000 0,0939115 0,10751441 ! leukocyte migration GO:0050900 60 43 0,000 0,0939115 0,10746092 ! neuromuscular process GO:0050905 79 43 0,000 0,0939115 0,10740748 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,0939115 0,1073541 ! tRNA processing GO:0008033 49 43 0,000 0,0939115 0,10730077 ! vesicle organization GO:0016050 79 43 0,000 0,0939115 0,10724749 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,0939115 0,10719426 ! methylation GO:0032259 64 43 0,000 0,0939115 0,10714109 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,0959898 0,10945788 ! glycolysis GO:0006096 53 44 0,000 0,0959898 0,10940364 ! regulation of action potential GO:0001508 71 44 0,000 0,0959898 0,10934945 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,0959898 0,10929532 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,0959898 0,10924124 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,0959898 0,10918721 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,0959898 0,10913324 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,0959898 0,10907932 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,0959898 0,10902545 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,0959898 0,10897164 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,0959898 0,10891788 ! positive regulation of cell cycle GO:0045787 77 45 0,000 0,09806346 0,11121595 ! RNA catabolic process GO:0006401 64 45 0,000 0,09806346 0,11116114 ! positive regulation of defense response GO:0031349 59 45 0,000 0,09806346 0,11110638 ! regulation of translational initiation GO:0006446 64 45 0,000 0,09806346 0,11105167 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,09806346 0,11099702 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,09806346 0,11094242 ! cell recognition GO:0008037 58 45 0,000 0,09806346 0,11088788 ! cell maturation GO:0048469 60 45 0,000 0,09806346 0,11083339 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,10013247 0,11311625 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,10013247 0,11306072 ! cell redox homeostasis GO:0045454 63 46 0,000 0,10013247 0,11300525 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,10013247 0,11294982 ! regulation of ossification GO:0030278 71 46 0,000 0,10013247 0,11289446 ! histone modification GO:0016570 68 46 0,000 0,10013247 0,11283914 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,10219686 0,1151091 ! viral infectious cycle GO:0019058 71 47 0,000 0,10219686 0,11505276 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,10219686 0,11499647 ! endocrine system development GO:0035270 83 47 0,000 0,10219686 0,11494024 ! covalent chromatin modification GO:0016569 75 47 0,000 0,10219686 0,11488406 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,10219686 0,11482794 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,10219686 0,11477187 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,10219686 0,11471585 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,10219686 0,1146599 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of protein polymerization GO:0032271 71 47 0,000 0,10219686 0,11460399 ! chloride transport GO:0006821 67 48 0,000 0,10425664 0,11685685 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,10425664 0,11679993 ! response to temperature stimulus GO:0009266 62 48 0,000 0,10425664 0,11674307 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,10425664 0,11668626 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,10425664 0,1166295 ! gastrulation GO:0007369 73 48 0,000 0,10425664 0,11657281 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,10425664 0,11651616 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,10425664 0,11645957 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,10425664 0,11640304 ! regulation of endocytosis GO:0030100 63 48 0,000 0,10425664 0,11634656 ! nuclear export GO:0051168 69 48 0,000 0,10425664 0,11629014 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,10425664 0,11623377 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,1063118 0,11846761 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,1063118 0,11841024 ! sensory perception of smell GO:0007608 61 49 0,000 0,1063118 0,11835292 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,1063118 0,11829567 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,1063118 0,11823846 ! RNA elongation GO:0006354 62 49 0,000 0,1063118 0,11818131 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,1063118 0,11812422 ! germ cell development GO:0007281 68 49 0,000 0,1063118 0,11806718 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,1063118 0,1180102 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,1063118 0,11795328 ! cartilage development GO:0051216 70 49 0,000 0,1063118 0,1178964 ! maintenance of location GO:0051235 84 49 0,000 0,1063118 0,11783959 ! regulation of actin filament length GO:0030832 72 50 0,000 0,10836237 0,12005464 ! ear development GO:0043583 72 50 0,000 0,10836237 0,11999684 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,10836237 0,1199391 ! membrane fusion GO:0006944 80 50 0,000 0,10836237 0,11988141 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,10836237 0,11982377 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,10836237 0,11976619 ! proton transport GO:0015992 75 50 0,000 0,10836237 0,11970867 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,10836237 0,1196512 ! positive regulation of secretion GO:0051047 71 51 0,000 0,11040835 0,12185182 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 0,000 0,11040835 0,12179338 ! hydrogen transport GO:0006818 77 51 0,000 0,11040835 0,12173499 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,11040835 0,12167666 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,11040835 0,12161839 ! adult behavior GO:0030534 80 51 0,000 0,11040835 0,12156017 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,11040835 0,12150201 ! transition metal ion transport GO:0000041 74 52 0,000 0,11244975 0,12368934 ! regulation of cellular component size GO:0032535 74 52 0,000 0,11244975 0,12363022 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,11244975 0,12357115 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,11244975 0,12351214 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,11244975 0,12345318 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,11448658 0,12562936 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,11448658 0,12556945 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,11448658 0,1255096 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,11448658 0,1254498 ! kidney development GO:0001822 90 53 0,000 0,11448658 0,12539006 ! single fertilization GO:0007338 59 53 0,000 0,11448658 0,12533038 ! amino acid transport GO:0006865 84 54 0,000 0,11651886 0,12749447 ! glucose catabolic process GO:0006007 66 54 0,000 0,11651886 0,12743384 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,11651886 0,12737327 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,11651886 0,12731276 ! DNA catabolic process GO:0006308 67 54 0,000 0,11651886 0,12725231 ! detection of external stimulus GO:0009581 66 54 0,000 0,11651886 0,12719192 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,11651886 0,12713158 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,11651886 0,1270713 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,11651886 0,12701108 ! exocytosis GO:0006887 74 55 0,000 0,11854658 0,12916018 ! mesoderm development GO:0007498 76 55 0,000 0,11854658 0,12909903 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,11854658 0,12903793 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,11854658 0,12897689 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,12056977 0,13111607 ! negative regulation of protein kinase activity GO:0006469 99 57 0,000 0,12258844 0,1332483 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,12258844 0,13318536 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,12258844 0,13312248 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,12258844 0,13305965 ! camera-type eye development GO:0043010 88 57 0,000 0,12258844 0,13299689 ! secondary metabolic process GO:0019748 84 57 0,000 0,12258844 0,13293418 ! developmental maturation GO:0021700 75 57 0,000 0,12258844 0,13287154 ! gonad development GO:0008406 79 57 0,000 0,12258844 0,13280895 ! negative regulation of kinase activity GO:0033673 100 58 0,000 0,12460258 0,13492747 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,12460258 0,13486397 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,12460258 0,13480053 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,12661222 0,13691025 ! lung development GO:0030324 94 59 0,000 0,12661222 0,13684591 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,12661222 0,13678163 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,12861735 0,13888259 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,12861735 0,13881742 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,12861735 0,13875231 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,12861735 0,13868726 ! regulation of heart contraction GO:0008016 91 60 0,000 0,12861735 0,13862227 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,12861735 0,13855734 ! fertilization GO:0009566 68 60 0,000 0,12861735 0,13849247 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,130618 0,14058091 ! meiosis GO:0007126 96 61 0,000 0,130618 0,14051516 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,130618 0,14044947 ! urogenital system development GO:0001655 101 61 0,000 0,130618 0,14038384 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,130618 0,14031827 ! extracellular matrix organization GO:0030198 103 61 0,000 0,130618 0,14025276 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,130618 0,14018731 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 0,000 0,130618 0,14012193 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,130618 0,1400566 ! amine catabolic process GO:0009310 90 62 0,000 0,13261417 0,14213075 ! neurotransmitter transport GO:0006836 81 62 0,000 0,13261417 0,14206455 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,13261417 0,14199842 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,13261417 0,14193234 ! respiratory tube development GO:0030323 99 62 0,000 0,13261417 0,14186633 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,13261417 0,14180037 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,13261417 0,14173448 ! meiotic cell cycle GO:0051321 97 62 0,000 0,13261417 0,14166865 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,13460587 0,14372958 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,13460587 0,14366288 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,13460587 0,14359625 ! regulation of lipase activity GO:0060191 109 63 0,000 0,13460587 0,14352968 ! negative regulation of cell size GO:0045792 108 64 0,000 0,13659312 0,14558117 ! appendage morphogenesis GO:0035107 93 64 0,000 0,13659312 0,14551374 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,13659312 0,14544637 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,13659312 0,14537907 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,13659312 0,14531183 ! hexose catabolic process GO:0019320 82 64 0,000 0,13659312 0,14524465 ! respiratory system development GO:0060541 100 64 0,000 0,13659312 0,14517753 ! adaptive immune response GO:0002250 94 64 0,000 0,13659312 0,14511047 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,13857591 0,14714893 ! appendage development GO:0048736 94 65 0,000 0,13857591 0,14708103 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,13857591 0,14701319 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,13857591 0,14694541 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,13857591 0,14687769 ! defense response to bacterium GO:0042742 73 65 0,000 0,13857591 0,14681004 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,13857591 0,14674244 ! activation of immune response GO:0002253 83 65 0,000 0,13857591 0,14667491 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,14055426 0,14870046 ! antigen processing and presentation GO:0019882 96 66 0,000 0,14055426 0,14863209 ! axon guidance GO:0007411 99 66 0,000 0,14055426 0,14856379 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,14055426 0,14849554 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,14252818 0,15051186 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,14252818 0,15044278 ! acute inflammatory response GO:0002526 92 68 0,000 0,14449769 0,15245169 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,14449769 0,15238179 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,14449769 0,15231195 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,14449769 0,15224218 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,14449769 0,15217247 ! rhythmic process GO:0048511 105 68 0,000 0,14449769 0,15210283 ! inorganic anion transport GO:0015698 93 68 0,000 0,14449769 0,15203325 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,14646278 0,15403035 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,14646278 0,15395996 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,14842347 0,15594974 ! humoral immune response GO:0006959 86 70 0,000 0,14842347 0,15587853 ! eye development GO:0001654 111 70 0,000 0,14842347 0,15580738 ! amine transport GO:0015837 101 70 0,000 0,14842347 0,1557363 ! positive regulation of phosphorylation GO:0042327 102 70 0,000 0,14842347 0,15566529 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,14842347 0,15559434 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,15037976 0,15757333 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,15037976 0,15750157 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,15037976 0,15742988 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,15037976 0,15735826 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,15037976 0,1572867 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 0,000 0,15233168 0,15925585 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of blood pressure GO:0008217 107 73 0,000 0,15427922 0,16121863 ! tube morphogenesis GO:0035239 118 73 0,000 0,15427922 0,16114542 ! mitochondrion organization GO:0007005 104 73 0,000 0,15427922 0,16107227 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,15427922 0,16099919 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,15427922 0,16092617 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,1562224 0,16287921 ! digestion GO:0007586 97 74 0,000 0,1562224 0,16280541 ! blood coagulation GO:0007596 116 75 0,000 0,15816123 0,16475128 GO:0050817|coagulation, ! negative regulation of growth GO:0045926 123 75 0,000 0,15816123 0,1646767 ! response to nutrient GO:0007584 104 75 0,000 0,15816123 0,16460219 ! regulation of ligase activity GO:0051340 114 75 0,000 0,15816123 0,16452774 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,15816123 0,16445336 ! amine biosynthetic process GO:0009309 97 76 0,000 0,16009571 0,16638958 ! tRNA metabolic process GO:0006399 95 76 0,000 0,16009571 0,16631443 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,16009571 0,16623934 ! regulation of protein transport GO:0051223 114 76 0,000 0,16009571 0,16616432 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,16202586 0,16809178 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,16202586 0,168016 ! regulation of DNA binding GO:0051101 119 77 0,000 0,16202586 0,16794028 ! gland development GO:0048732 148 77 0,000 0,16202586 0,16786463 ! sex differentiation GO:0007548 105 77 0,000 0,16202586 0,16778905 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,16202586 0,16771354 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,16202586 0,1676381 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,16395169 0,16955435 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,16395169 0,16947815 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,16395169 0,16940201 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,1658732 0,17131044 ! cellular respiration GO:0045333 107 79 0,000 0,1658732 0,17123355 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,1658732 0,17115673 ! regulation of lyase activity GO:0051339 133 79 0,000 0,1658732 0,17107998 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,1658732 0,17100329 ! chromatin assembly GO:0031497 102 80 0,000 0,1677904 0,17290229 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,1677904 0,17282486 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,1677904 0,1727475 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,1677904 0,17267021 ! forebrain development GO:0030900 131 80 0,000 0,1677904 0,17259299 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,1697033 0,17448261 ! hemostasis GO:0007599 125 81 0,000 0,1697033 0,17440465 ! mRNA transport GO:0051028 121 81 0,000 0,1697033 0,17432675 ! vitamin metabolic process GO:0006766 103 81 0,000 0,1697033 0,17424893 ! ossification GO:0001503 134 82 0,000 0,17161192 0,17613004 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,17161192 0,17605148 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,17351626 0,17792573 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,17351626 0,17784644 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,17351626 0,17776722 ! regulation of defense response GO:0031347 117 84 0,000 0,17541633 0,17963382 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,17541633 0,17955388 ! sterol metabolic process GO:0016125 120 84 0,000 0,17541633 0,17947401 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,17731215 0,18133301 ! rRNA metabolic process GO:0016072 107 85 0,000 0,17731215 0,18125242 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,17731215 0,1811719 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,17731215 0,18109145 ! regulation of protein localization GO:0032880 132 85 0,000 0,17731215 0,18101107 ! regulation of membrane potential GO:0042391 128 85 0,000 0,17731215 0,18093076 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,17731215 0,18085053 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,17920371 0,18269882 ! cell cycle arrest GO:0007050 150 86 0,000 0,17920371 0,18261787 ! nucleosome organization GO:0034728 114 87 0,000 0,18109103 0,18445942 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,18109103 0,18437777 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,18109103 0,18429618 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,18109103 0,18421467 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,18109103 0,18413323 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,18109103 0,18405187 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,18297412 0,1858836 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,18297412 0,18580154 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,18297412 0,18571954 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,18297412 0,18563762 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,18485299 0,18746114 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,18485299 0,18737853 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,18485299 0,18729598 ! hormone metabolic process GO:0042445 121 90 0,000 0,18672765 0,1891121 ! RNA localization GO:0006403 135 91 0,000 0,1885981 0,19092237 ! ATP metabolic process GO:0046034 137 91 0,000 0,1885981 0,19083837 ! response to virus GO:0009615 122 91 0,000 0,1885981 0,19075445 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,19046435 0,19255737 ! cell fate commitment GO:0045165 141 92 0,000 0,19046435 0,19247277 ! positive regulation of immune response GO:0050778 121 92 0,000 0,19046435 0,19238824 ! DNA recombination GO:0006310 146 92 0,000 0,19046435 0,19230378 ! sulfur metabolic process GO:0006790 118 92 0,000 0,19046435 0,1922194 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,19232643 0,1940135 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,19232643 0,19392844 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,19232643 0,19384346 ! electron transport chain GO:0022900 123 94 0,000 0,19418432 0,19563028 ! response to oxidative stress GO:0006979 141 94 0,000 0,19418432 0,19554463 ! regulation of binding GO:0051098 151 95 0,000 0,19603805 0,19732495 ! angiogenesis GO:0001525 149 95 0,000 0,19603805 0,19723863 ! carboxylic acid transport GO:0046942 147 95 0,000 0,19603805 0,19715239 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,19788762 0,19892549 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,19788762 0,19883859 ! protein maturation GO:0051604 129 96 0,000 0,19788762 0,19875176 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,19973304 0,20051768 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,19973304 0,20043019 ! calcium ion transport GO:0006816 167 99 0,000 0,20341147 0,20403244 ! extracellular structure organization GO:0043062 156 99 0,000 0,20341147 0,2039435 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,20341147 0,20385464 ! regulation of translation GO:0006417 151 100 0,000 0,2052445 0,20560207 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,2052445 0,20551256 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,2052445 0,20542313 ! divalent metal ion transport GO:0070838 171 100 0,000 0,2052445 0,20533378 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,2052445 0,2052445