pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/787-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! localization within membrane GO:0051668 15 9 3,000 4,356E-09 1,002E-05 ! regulation of respiratory burst GO:0060263 8 5 2,000 1,482E-07 1,705E-04 ! negative regulation of endocytosis GO:0045806 8 6 2,000 2,959E-07 2,269E-04 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 2,000 8,257E-07 4,748E-04 GO:0046579|positive regulation of Ras protein signal transduction, ! ruffle organization GO:0031529 11 8 2,000 8,257E-07 3,798E-04 ! lamellipodium assembly GO:0030032 9 8 2,000 8,257E-07 3,165E-04 ! actin filament polymerization GO:0030041 17 11 2,000 2,42E-06 7,952E-04 ! actin polymerization or depolymerization GO:0008154 31 17 2,000 9,869E-06 2,837E-03 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 2,000 1,646E-05 4,206E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,646E-05 3,785E-03 ! vasculogenesis GO:0001570 33 22 2,000 2,216E-05 4,632E-03 ! negative regulation of transport GO:0051051 116 73 3,000 3,347E-05 6,415E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 3,714E-05 6,571E-03 ! glial cell fate commitment GO:0021781 12 5 1,000 6,161E-05 0,01012221 ! positive regulation of vasoconstriction GO:0045907 9 5 1,000 6,161E-05 9,447E-03 ! negative regulation of T cell mediated immunity GO:0002710 11 5 1,000 6,161E-05 8,857E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 6,161E-05 8,336E-03 ! cytokinesis GO:0000910 52 33 2,000 7,699E-05 9,837E-03 ! protein homooligomerization GO:0051260 52 35 2,000 9,203E-05 0,0111407 ! gas homeostasis GO:0033483 11 6 1,000 9,227E-05 0,0106113 ! blastocyst growth GO:0001832 15 6 1,000 9,227E-05 0,010106 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 9,227E-05 9,647E-03 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 9,227E-05 9,227E-03 ! cell growth GO:0016049 61 39 2,000 1,276E-04 0,01222904 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,29E-04 0,01186563 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 1,29E-04 0,01140926 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 1,29E-04 0,0109867 GO:0021940|positive regulation of granule cell precursor proliferation, ! vesicle fusion GO:0006906 15 7 1,000 1,29E-04 0,01059431 ! lymph node development GO:0048535 9 7 1,000 1,29E-04 0,01022899 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 1,000 1,29E-04 9,888E-03 ! endosome to lysosome transport GO:0008333 10 7 1,000 1,29E-04 9,569E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,717E-04 0,01234025 ! polyamine biosynthetic process GO:0006596 9 8 1,000 1,717E-04 0,0119663 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,717E-04 0,01161435 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,717E-04 0,01128251 ! positive regulation of cell cycle GO:0045787 77 45 2,000 1,961E-04 0,01252592 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 2,204E-04 0,01370002 ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 2,204E-04 0,01333949 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 2,204E-04 0,01299745 GO:0010469|regulation of receptor activity, ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 1,000 2,204E-04 0,01267252 GO:0002820|negative regulation of adaptive immune response, ! positive regulation of protein polymerization GO:0032273 15 9 1,000 2,204E-04 0,01236343 ! regulation of protein polymerization GO:0032271 71 47 2,000 2,233E-04 0,01222567 ! regulation of endocytosis GO:0030100 63 48 2,000 2,377E-04 0,01271511 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,75E-04 0,01437754 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,75E-04 0,01405804 GO:0010812|negative regulation of cell-substrate adhesion, ! polyamine metabolic process GO:0006595 14 10 1,000 2,75E-04 0,01375243 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 2,75E-04 0,01345983 ! negative regulation of immune effector process GO:0002698 16 10 1,000 2,75E-04 0,01317942 ! positive regulation of organelle organization GO:0010638 82 51 2,000 2,847E-04 0,01336427 ! cell projection assembly GO:0030031 76 53 2,000 3,192E-04 0,01468116 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 3,356E-04 0,01513638 ! chromatin silencing GO:0006342 19 11 1,000 3,356E-04 0,0148453 ! regulation of protein complex assembly GO:0043254 81 54 2,000 3,373E-04 0,01463917 ! gland morphogenesis GO:0022612 23 12 1,000 4,021E-04 0,01712713 ! actin filament organization GO:0007015 95 59 2,000 4,383E-04 0,01832748 ! regulation of vesicle-mediated transport GO:0060627 79 60 2,000 4,605E-04 0,01891439 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 4,745E-04 0,01914516 ! lipid localization GO:0010876 24 13 1,000 4,745E-04 0,01881507 GO:0019915|lipid storage, ! organelle fusion GO:0048284 28 13 1,000 4,745E-04 0,01849617 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,745E-04 0,0181879 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 4,745E-04 0,01788974 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 5,316E-04 0,01972128 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 5,527E-04 0,02017646 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 5,527E-04 0,0198612 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 1,000 5,527E-04 0,01955565 ! activation of MAPKK activity GO:0000186 21 14 1,000 5,527E-04 0,01925935 ! epidermis morphogenesis GO:0048730 29 14 1,000 5,527E-04 0,0189719 ! lysosomal transport GO:0007041 20 14 1,000 5,527E-04 0,0186929 ! protein oligomerization GO:0051259 100 65 2,000 5,827E-04 0,01942348 ! regulation of Rho protein signal transduction GO:0035023 111 66 2,000 6,094E-04 0,02002259 ! embryonic hindlimb morphogenesis GO:0035116 25 15 1,000 6,367E-04 0,02062435 ! lipid phosphorylation GO:0046834 23 15 1,000 6,367E-04 0,0203379 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 6,367E-04 0,0200593 ! regulation of vasodilation GO:0042312 24 15 1,000 6,367E-04 0,01978822 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 6,367E-04 0,01952438 ! positive regulation of phosphorylation GO:0042327 102 70 2,000 7,239E-04 0,02190681 ! negative regulation of immune response GO:0050777 28 16 1,000 7,265E-04 0,02169926 ! regulation of peptidase activity GO:0052547 106 72 2,000 7,859E-04 0,02317444 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 2,000 7,859E-04 0,02288109 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 8,22E-04 0,02363245 ! inactivation of MAPK activity GO:0000188 27 17 1,000 8,22E-04 0,02334069 ! vacuolar transport GO:0007034 24 17 1,000 8,22E-04 0,02305605 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 8,22E-04 0,02277826 ! regulation of protein transport GO:0051223 114 76 2,000 9,199E-04 0,02518833 GO:0070201|regulation of establishment of protein localization, ! positive regulation of anti-apoptosis GO:0045768 29 18 1,000 9,233E-04 0,02498261 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 9,233E-04 0,02469211 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 9,233E-04 0,02440829 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 1,03E-03 0,02692677 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 1,03E-03 0,02662422 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,03E-03 0,02632839 ! sarcomere organization GO:0045214 23 19 1,000 1,03E-03 0,02603907 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 1,03E-03 0,02575604 ! hindlimb morphogenesis GO:0035137 32 20 1,000 1,143E-03 0,02826487 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 1,000 1,143E-03 0,02796418 ! regulation of cell killing GO:0031341 34 21 1,000 1,261E-03 0,03053359 ! vesicle docking GO:0048278 27 21 1,000 1,261E-03 0,03021553 ! regulation of DNA recombination GO:0000018 40 21 1,000 1,261E-03 0,02990403 ! regulation of vasoconstriction GO:0019229 31 21 1,000 1,261E-03 0,02959889 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 1,000 1,261E-03 0,02929991 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 1,272E-03 0,0292621 ! regulation of protein localization GO:0032880 132 85 2,000 1,272E-03 0,02897238 ! regulation of anti-apoptosis GO:0045767 36 22 1,000 1,385E-03 0,031232 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 1,385E-03 0,03092878 GO:0010810|regulation of cell-substrate adhesion, ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 1,385E-03 0,03063139 ! membrane depolarization GO:0051899 35 22 1,000 1,385E-03 0,03033966 ! regulation of blood coagulation GO:0030193 34 22 1,000 1,385E-03 0,03005344 ! blastocyst development GO:0001824 37 22 1,000 1,385E-03 0,02977257 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 1,515E-03 0,03225454 ! cell fate determination GO:0001709 45 23 1,000 1,515E-03 0,03195862 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 1,648E-03 0,03446436 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 1,65E-03 0,03418112 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 1,65E-03 0,03387593 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 1,65E-03 0,03357614 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 1,65E-03 0,03328161 ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 1,79E-03 0,03580385 ! positive regulation of nuclear division GO:0051785 39 25 1,000 1,79E-03 0,0354952 GO:0045840|positive regulation of mitosis, ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 1,805E-03 0,03549025 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 1,936E-03 0,03774105 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 1,936E-03 0,0374239 ! regulation of coagulation GO:0050818 39 26 1,000 1,936E-03 0,03711204 ! membrane docking GO:0022406 39 27 1,000 2,088E-03 0,03968632 ! myofibril assembly GO:0030239 36 27 1,000 2,088E-03 0,03936102 GO:0055002|striated muscle cell development, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 2,088E-03 0,03904102 ! gene silencing GO:0016458 41 27 1,000 2,088E-03 0,03872617 ! cholesterol homeostasis GO:0042632 46 28 1,000 2,245E-03 0,04130546 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 1,000 2,245E-03 0,04097764 ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 2,245E-03 0,04065498 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 2,245E-03 0,04033736 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 2,407E-03 0,04292088 ! muscle cell development GO:0055001 38 29 1,000 2,407E-03 0,04259072 ! cholesterol transport GO:0030301 46 30 1,000 2,575E-03 0,04521234 GO:0015918|sterol transport, ! hindbrain development GO:0030902 45 30 1,000 2,575E-03 0,04486983 ! regulation of microtubule-based process GO:0032886 58 30 1,000 2,575E-03 0,04453246 ! negative regulation of secretion GO:0051048 49 31 1,000 2,748E-03 0,04717307 ! mammary gland development GO:0030879 57 31 1,000 2,748E-03 0,04682364 ! glial cell differentiation GO:0010001 55 31 1,000 2,748E-03 0,04647934 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 2,748E-03 0,04614008 ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 2,748E-03 0,04580573 ! neutral lipid metabolic process GO:0006638 41 32 1,000 2,927E-03 0,0484306 GO:0006639|acylglycerol metabolic process, ! calcium-mediated signaling GO:0019722 50 32 1,000 2,927E-03 0,04808466 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 2,927E-03 0,04774364 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 3,111E-03 0,05038551 ! actomyosin structure organization GO:0031032 43 33 1,000 3,111E-03 0,05003316 ! lipid homeostasis GO:0055088 55 33 1,000 3,111E-03 0,04968571 ! glycerol ether metabolic process GO:0006662 44 34 1,000 3,3E-03 0,05234342 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 3,3E-03 0,05198491 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 3,3E-03 0,05163127 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 3,494E-03 0,05430375 ! keratinocyte differentiation GO:0030216 47 35 1,000 3,494E-03 0,0539393 ! Rho protein signal transduction GO:0007266 51 35 1,000 3,494E-03 0,0535797 ! organic ether metabolic process GO:0018904 46 36 1,000 3,694E-03 0,05626595 ! tissue remodeling GO:0048771 62 36 1,000 3,694E-03 0,05589578 ! regulation of protein secretion GO:0050708 51 37 1,000 3,899E-03 0,05861009 ! gliogenesis GO:0042063 71 38 1,000 4,109E-03 0,06136657 ! striated muscle cell differentiation GO:0051146 54 38 1,000 4,109E-03 0,06097066 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 4,324E-03 0,06375271 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 4,324E-03 0,06334664 ! developmental growth GO:0048589 62 39 1,000 4,324E-03 0,06294571 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 4,544E-03 0,06573708 ! response to calcium ion GO:0051592 58 40 1,000 4,544E-03 0,06532622 ! T cell differentiation GO:0030217 65 40 1,000 4,544E-03 0,06492047 ! epidermal cell differentiation GO:0009913 53 40 1,000 4,544E-03 0,06451972 ! positive regulation of protein transport GO:0051222 55 40 1,000 4,544E-03 0,0641239 ! endosome transport GO:0016197 71 41 1,000 4,77E-03 0,06689458 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 4,77E-03 0,06648915 ! regulation of T cell differentiation GO:0045580 59 41 1,000 4,77E-03 0,06608862 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 5E-03 0,06886772 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 5E-03 0,06845779 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 5E-03 0,06805272 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 5E-03 0,06765241 ! regulation of cell shape GO:0008360 78 42 1,000 5E-03 0,06725678 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 5,236E-03 0,07001588 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 5,236E-03 0,06961116 ! vesicle organization GO:0016050 79 43 1,000 5,236E-03 0,0692111 ! response to insulin stimulus GO:0032868 63 43 1,000 5,236E-03 0,06881561 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 5,722E-03 0,07477847 ! regulation of adaptive immune response GO:0002819 72 46 1,000 5,973E-03 0,07761214 ! response to UV GO:0009411 75 46 1,000 5,973E-03 0,07717612 ! covalent chromatin modification GO:0016569 75 47 1,000 6,228E-03 0,08002836 ! negative regulation of immune system process GO:0002683 73 47 1,000 6,228E-03 0,07958376 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 6,228E-03 0,07914407 ! regulation of muscle contraction GO:0006937 69 48 1,000 6,489E-03 0,08200074 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 6,489E-03 0,08155265 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 6,489E-03 0,08110943 ! regulation of angiogenesis GO:0045765 94 49 1,000 6,754E-03 0,08397008 ! regulation of intracellular transport GO:0032386 78 49 1,000 6,754E-03 0,08351863 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 6,754E-03 0,083072 ! regulation of actin filament length GO:0030832 72 50 1,000 7,024E-03 0,08593621 ! membrane fusion GO:0006944 80 50 1,000 7,024E-03 0,08548153 ! lipid modification GO:0030258 73 50 1,000 7,024E-03 0,08503162 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 7,024E-03 0,08458643 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 7,299E-03 0,08744119 ! activation of phospholipase C activity GO:0007202 87 51 1,000 7,299E-03 0,08698813 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of cell migration GO:0030335 92 51 1,000 7,299E-03 0,08653974 ! regulation of cellular component size GO:0032535 74 52 1,000 7,579E-03 0,08939748 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 7,579E-03 0,08894137 ! kidney development GO:0001822 90 53 1,000 7,864E-03 0,09181396 ! regulation of mitosis GO:0007088 84 54 1,000 8,154E-03 0,09471301 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 8,154E-03 0,09423706 ! positive regulation of lipase activity GO:0060193 90 54 1,000 8,154E-03 0,09376588 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 8,747E-03 0,10008733 ! negative regulation of response to stimulus GO:0048585 80 56 1,000 8,747E-03 0,09959185 ! positive regulation of cell motion GO:0051272 99 56 1,000 8,747E-03 0,09910125 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 9,05E-03 0,10203919 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 9,05E-03 0,10154143 ! negative regulation of kinase activity GO:0033673 100 58 1,000 9,359E-03 0,10449123 ! activation of MAPK activity GO:0000187 84 59 1,000 9,672E-03 0,10746422 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 9,989E-03 0,11045981 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 9,989E-03 0,1099313 GO:0035113|embryonic appendage morphogenesis, ! urogenital system development GO:0001655 101 61 1,000 0,01031164 0,11293705 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,01031164 0,1124018 ! negative regulation of transferase activity GO:0051348 105 61 1,000 0,01031164 0,11187161 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01096983 0,11845357 ! appendage morphogenesis GO:0035107 93 64 1,000 0,01130574 0,12151024 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,01130574 0,12094507 ! regulation of caspase activity GO:0043281 97 65 1,000 0,01164615 0,12400992 ! appendage development GO:0048736 94 65 1,000 0,01164615 0,12343844 GO:0060173|limb development, ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,01164615 0,12287221 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,01164615 0,12231115 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,01199105 0,12536096 ! regulation of immune effector process GO:0002697 101 66 1,000 0,01199105 0,12479371 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,01234041 0,12785108 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01252261 0,12915697 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01252261 0,12858038 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01252261 0,12800891 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01252261 0,1274425 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01252261 0,12688108 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01252261 0,12632458 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01252261 0,12577295 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01252261 0,12522611 ! sleep GO:0030431 11 5 0,000 0,01252261 0,124684 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01252261 0,12414657 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01252261 0,12361375 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01252261 0,12308549 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01252261 0,12256172 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01252261 0,12204239 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01252261 0,12152745 ! tongue development GO:0043586 6 5 0,000 0,01252261 0,12101683 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01252261 0,12051048 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01252261 0,12000835 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01252261 0,11951039 ! cobalt ion transport GO:0006824 9 5 0,000 0,01252261 0,11901655 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01252261 0,11852677 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01252261 0,118041 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01252261 0,1175592 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01252261 0,11708132 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01252261 0,11660731 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01252261 0,11613711 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01252261 0,1156707 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01252261 0,11520802 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01252261 0,11474902 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01252261 0,11429367 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01252261 0,11384192 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01252261 0,11339372 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01252261 0,11294904 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01252261 0,11250783 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01252261 0,11207006 ! malate metabolic process GO:0006108 7 5 0,000 0,01252261 0,11163568 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01252261 0,11120465 ! behavioral response to pain GO:0048266 7 5 0,000 0,01252261 0,11077694 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01252261 0,11035251 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01252261 0,10993131 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01252261 0,10951333 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01252261 0,1090985 ! mating behavior GO:0007617 6 5 0,000 0,01252261 0,10868681 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01252261 0,10827821 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01252261 0,10787268 ! rhythmic behavior GO:0007622 12 5 0,000 0,01252261 0,10747017 ! copulation GO:0007620 7 5 0,000 0,01252261 0,10707065 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01252261 0,10667409 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01252261 0,10628046 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01252261 0,10588972 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01252261 0,10550185 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01252261 0,1051168 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01252261 0,10473456 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01252261 0,10435509 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01252261 0,10397836 ! response to protozoan GO:0001562 9 5 0,000 0,01252261 0,10360433 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,01252261 0,10323299 ! lymph vessel development GO:0001945 7 5 0,000 0,01252261 0,1028643 ! endochondral ossification GO:0001958 12 5 0,000 0,01252261 0,10249824 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01252261 0,10213477 ! parathyroid gland development GO:0060017 8 5 0,000 0,01252261 0,10177387 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01252261 0,10141551 ! anagen GO:0042640 6 5 0,000 0,01252261 0,10105966 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01252261 0,10070631 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01252261 0,10035542 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01252261 0,10000696 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01252261 0,09966092 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01252261 0,09931726 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01252261 0,09897596 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01252261 0,098637 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01252261 0,09830036 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01252261 0,097966 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01252261 0,09763391 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01252261 0,09730407 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01252261 0,09697645 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01252261 0,09665102 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01252261 0,09632777 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01252261 0,09600668 ! ovulation GO:0030728 6 5 0,000 0,01252261 0,09568772 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01252261 0,09537088 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01252261 0,09505612 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01252261 0,09474344 ! response to pH GO:0009268 9 5 0,000 0,01252261 0,0944328 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01252261 0,0941242 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01252261 0,0938176 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01252261 0,093513 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01252261 0,09321037 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01252261 0,09290969 ! polyol catabolic process GO:0046174 7 5 0,000 0,01252261 0,09261095 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01252261 0,09231412 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01252261 0,09201918 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01252261 0,09172613 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01252261 0,09143493 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01252261 0,09114558 ! urea metabolic process GO:0019627 6 5 0,000 0,01252261 0,09085806 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01252261 0,09057234 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01252261 0,09028842 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01252261 0,09000626 ! neutrophil activation GO:0042119 5 5 0,000 0,01252261 0,08972587 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01252261 0,08944722 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01252261 0,08917029 ! response to food GO:0032094 5 5 0,000 0,01252261 0,08889508 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01252261 0,08862155 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01252261 0,08834971 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01252261 0,08807952 ! forebrain neuron development GO:0021884 7 5 0,000 0,01252261 0,08781099 ! melanosome organization GO:0032438 7 5 0,000 0,01252261 0,08754409 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01252261 0,0872788 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01252261 0,08701512 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01252261 0,08675303 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01252261 0,08649251 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01252261 0,08623355 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01252261 0,08597613 ! nucleoside transport GO:0015858 6 5 0,000 0,01252261 0,08572025 ! nucleoside salvage GO:0043174 7 5 0,000 0,01252261 0,08546589 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01252261 0,08521303 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01252261 0,08496167 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01252261 0,08471178 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01252261 0,08446336 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01252261 0,08421639 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01252261 0,08397086 ! depyrimidination GO:0045008 8 5 0,000 0,01252261 0,08372676 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01252261 0,08348407 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01252261 0,08324279 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01252261 0,08300289 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01252261 0,08276438 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01252261 0,08252723 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01252261 0,08229144 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01252261 0,08205699 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01252261 0,08182388 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01252261 0,08159208 ! monocyte differentiation GO:0030224 8 5 0,000 0,01252261 0,08136159 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01252261 0,08113241 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01252261 0,08090451 ! centrosome duplication GO:0051298 5 5 0,000 0,01252261 0,08067788 ! response to UV-C GO:0010225 6 5 0,000 0,01252261 0,08045253 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01252261 0,08022842 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01252261 0,08000557 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01252261 0,07978395 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01252261 0,07956355 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01252261 0,07934437 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01252261 0,07912639 ! melanosome transport GO:0032402 8 5 0,000 0,01252261 0,0789096 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01252261 0,078694 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01252261 0,07847958 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01252261 0,07826632 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01252261 0,07805421 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01252261 0,07784326 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01252261 0,07763344 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01252261 0,07742474 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01252261 0,07721717 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01252261 0,07701071 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01252261 0,07680535 ! neural tube patterning GO:0021532 6 5 0,000 0,01252261 0,07660108 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01252261 0,07639789 ! histone demethylation GO:0016577 9 5 0,000 0,01252261 0,07619578 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01252261 0,07599473 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01252261 0,07579475 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01252261 0,07559581 ! enteric nervous system development GO:0048484 8 5 0,000 0,01252261 0,07539792 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01252261 0,07520106 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01252261 0,07500522 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01252261 0,0748104 ! transcription termination GO:0006353 8 5 0,000 0,01252261 0,07461659 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01252261 0,07442378 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01252261 0,07423197 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01252261 0,07404114 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01252261 0,07385129 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01252261 0,07366242 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01252261 0,0734745 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01252261 0,07328754 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01252261 0,07310153 ! apical protein localization GO:0045176 6 5 0,000 0,01252261 0,07291647 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01252261 0,07273233 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01252261 0,07254913 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01252261 0,07236685 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01252261 0,07218547 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01252261 0,07200501 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01252261 0,07182545 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01252261 0,07164678 ! glial cell migration GO:0008347 10 5 0,000 0,01252261 0,07146899 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01252261 0,07129209 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01252261 0,07111606 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01252261 0,0709409 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01252261 0,0707666 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01252261 0,07059315 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01252261 0,07042055 ! neural plate development GO:0001840 6 5 0,000 0,01252261 0,07024879 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01252261 0,07007787 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01252261 0,06990778 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01252261 0,06973851 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01252261 0,06957006 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01252261 0,06940242 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01252261 0,06923559 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01252261 0,06906956 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01252261 0,06890432 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01252261 0,06873987 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01252261 0,0685762 ! spindle assembly GO:0051225 5 5 0,000 0,01252261 0,06841331 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01252261 0,0682512 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01252261 0,06808985 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01252261 0,06792926 ! organ regeneration GO:0031100 7 5 0,000 0,01252261 0,06776942 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01252261 0,06761034 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01252261 0,067452 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01252261 0,0672944 GO:0055081|anion homeostasis, ! activation of protein kinase activity GO:0032147 102 69 1,000 0,01305242 0,06997801 ! response to metal ion GO:0010038 103 70 1,000 0,01341502 0,07175478 ! eye development GO:0001654 111 70 1,000 0,01341502 0,0715883 ! muscle cell differentiation GO:0042692 104 71 1,000 0,013782 0,07337637 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,013782 0,07320691 ! response to hypoxia GO:0001666 132 72 1,000 0,01415331 0,07500604 ! tube morphogenesis GO:0035239 118 73 1,000 0,01452895 0,07681974 ! response to oxygen levels GO:0070482 137 74 1,000 0,01490889 0,0786478 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,01490889 0,07846783 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,01490889 0,07828868 ! tRNA transcription GO:0009304 11 6 0,000 0,01500868 0,07863317 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01500868 0,07845446 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01500868 0,07827655 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01500868 0,07809946 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01500868 0,07792316 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01500868 0,07774766 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01500868 0,07757294 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01500868 0,07739901 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01500868 0,07722586 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01500868 0,07705348 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01500868 0,07688187 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01500868 0,07671102 ! prostate gland development GO:0030850 9 6 0,000 0,01500868 0,07654093 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01500868 0,07637159 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01500868 0,076203 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01500868 0,07603515 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01500868 0,07586804 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01500868 0,07570167 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01500868 0,07553602 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01500868 0,07537109 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01500868 0,07520689 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01500868 0,07504339 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01500868 0,07488061 ! neuron adhesion GO:0007158 9 6 0,000 0,01500868 0,07471853 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01500868 0,07455715 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01500868 0,07439647 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01500868 0,07423647 ! signal peptide processing GO:0006465 8 6 0,000 0,01500868 0,07407717 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01500868 0,07391854 ! mRNA stabilization GO:0048255 15 6 0,000 0,01500868 0,0737606 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01500868 0,07360333 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01500868 0,07344672 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01500868 0,07329079 ! opsonization GO:0008228 8 6 0,000 0,01500868 0,07313551 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01500868 0,07298089 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01500868 0,07282692 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01500868 0,0726736 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01500868 0,07252092 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01500868 0,07236889 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01500868 0,07221749 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01500868 0,07206672 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01500868 0,07191658 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01500868 0,07176707 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01500868 0,07161817 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01500868 0,0714699 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01500868 0,07132223 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01500868 0,07117518 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01500868 0,07102872 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01500868 0,07088288 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01500868 0,07073762 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01500868 0,07059297 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01500868 0,0704489 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01500868 0,07030542 ! thymic T cell selection GO:0045061 12 6 0,000 0,01500868 0,07016252 ! protein lipoylation GO:0009249 10 6 0,000 0,01500868 0,0700202 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01500868 0,06987846 ! pigment granule organization GO:0048753 11 6 0,000 0,01500868 0,06973729 ! drug transport GO:0015893 6 6 0,000 0,01500868 0,06959669 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01500868 0,06945666 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01500868 0,06931719 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01500868 0,06917828 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01500868 0,06903992 ! histidine metabolic process GO:0006547 6 6 0,000 0,01500868 0,06890212 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01500868 0,06876486 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01500868 0,06862815 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01500868 0,06849198 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01500868 0,06835636 ! adenohypophysis development GO:0021984 10 6 0,000 0,01500868 0,06822127 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01500868 0,06808671 ! hyperosmotic response GO:0006972 8 6 0,000 0,01500868 0,06795268 ! microtubule nucleation GO:0007020 10 6 0,000 0,01500868 0,06781918 ! ER overload response GO:0006983 7 6 0,000 0,01500868 0,0676862 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01500868 0,06755374 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01500868 0,0674218 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01500868 0,06729037 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01500868 0,06715946 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01500868 0,06702905 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01500868 0,06689915 ! response to dietary excess GO:0002021 7 6 0,000 0,01500868 0,06676975 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01500868 0,06664085 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01500868 0,06651245 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01500868 0,06638454 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01500868 0,06625712 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01500868 0,06613019 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01500868 0,06600375 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01500868 0,06587779 ! neuron apoptosis GO:0051402 8 6 0,000 0,01500868 0,06575231 ! organic alcohol transport GO:0015850 9 6 0,000 0,01500868 0,0656273 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01500868 0,06550277 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01500868 0,06537871 ! male sex determination GO:0030238 9 6 0,000 0,01500868 0,06525512 ! carnitine transport GO:0015879 8 6 0,000 0,01500868 0,065132 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01500868 0,06500934 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01500868 0,06488714 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01500868 0,0647654 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01500868 0,06464412 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01500868 0,06452329 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01500868 0,06440291 ! parturition GO:0007567 12 6 0,000 0,01500868 0,06428298 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01500868 0,06416349 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01500868 0,06404445 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01500868 0,06392585 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01500868 0,06380769 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01500868 0,06368996 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01500868 0,06357267 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01500868 0,06345581 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01500868 0,06333938 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01500868 0,06322337 ! macrophage differentiation GO:0030225 10 6 0,000 0,01500868 0,06310779 ! astrocyte development GO:0014002 14 6 0,000 0,01500868 0,06299263 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01500868 0,06287789 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01500868 0,06276356 ! interaction with symbiont GO:0051702 8 6 0,000 0,01500868 0,06264966 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01500868 0,06253616 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01500868 0,06242307 ! eating behavior GO:0042755 6 6 0,000 0,01500868 0,0623104 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01500868 0,06219813 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01500868 0,06208626 ! response to copper ion GO:0046688 9 6 0,000 0,01500868 0,06197479 ! DNA topological change GO:0006265 8 6 0,000 0,01500868 0,06186373 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01500868 0,06175306 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01500868 0,06164279 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01500868 0,06153291 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01500868 0,06142342 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01500868 0,06131432 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01500868 0,0612056 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01500868 0,06109727 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01500868 0,06098933 ! hair follicle maturation GO:0048820 7 6 0,000 0,01500868 0,06088176 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01500868 0,06077458 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01500868 0,06066777 ! Schwann cell development GO:0014044 14 6 0,000 0,01500868 0,06056133 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01500868 0,06045527 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01500868 0,06034958 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01500868 0,06024426 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01500868 0,0601393 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01500868 0,06003471 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01500868 0,05993049 ! histone ubiquitination GO:0016574 7 6 0,000 0,01500868 0,05982662 ! regulation of meiosis GO:0040020 10 6 0,000 0,01500868 0,05972311 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01500868 0,05961997 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01500868 0,05951717 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01500868 0,05941473 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01500868 0,05931265 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01500868 0,05921091 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01500868 0,05910952 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01500868 0,05900848 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01500868 0,05890778 ! receptor internalization GO:0031623 9 6 0,000 0,01500868 0,05880743 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01500868 0,05870742 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01500868 0,05860774 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01500868 0,05850841 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01500868 0,05840941 ! protein deubiquitination GO:0016579 8 6 0,000 0,01500868 0,05831074 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01500868 0,05821241 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01500868 0,05811441 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01500868 0,05801674 ! axonal fasciculation GO:0007413 9 6 0,000 0,01500868 0,0579194 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01500868 0,05782238 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01500868 0,05772569 ! midbrain development GO:0030901 6 6 0,000 0,01500868 0,05762932 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01500868 0,05753327 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01500868 0,05743754 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01500868 0,05734213 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01500868 0,05724703 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01500868 0,05715225 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01500868 0,05705779 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01500868 0,05696363 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01500868 0,05686979 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01500868 0,05677625 ! adult feeding behavior GO:0008343 6 6 0,000 0,01500868 0,05668302 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01500868 0,0565901 ! pigment granule transport GO:0051904 12 6 0,000 0,01500868 0,05649748 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01500868 0,05640516 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01500868 0,05631315 ! catecholamine transport GO:0051937 7 6 0,000 0,01500868 0,05622143 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01500868 0,05613002 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01500868 0,0560389 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01500868 0,05594807 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01500868 0,05585754 ! protein prenylation GO:0018342 10 6 0,000 0,01500868 0,0557673 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01500868 0,05567736 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01500868 0,0555877 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01500868 0,05549833 ! response to inorganic substance GO:0010035 115 75 1,000 0,0152931 0,05645927 ! amine biosynthetic process GO:0009309 97 76 1,000 0,01568156 0,05780063 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,01568156 0,05770815 ! gland development GO:0048732 148 77 1,000 0,01607426 0,05905877 ! T cell activation GO:0042110 134 79 1,000 0,01687224 0,0618918 ! forebrain development GO:0030900 131 80 1,000 0,01727749 0,06327743 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01748863 0,06394888 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01748863 0,06384738 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01748863 0,06374619 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01748863 0,06364533 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01748863 0,06354478 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01748863 0,06344455 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01748863 0,06334464 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01748863 0,06324504 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01748863 0,06314576 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01748863 0,06304678 ! reproductive behavior GO:0019098 12 7 0,000 0,01748863 0,06294812 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01748863 0,06284976 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,01748863 0,06275171 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01748863 0,06265397 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,01748863 0,06255653 ! oligopeptide transport GO:0006857 11 7 0,000 0,01748863 0,06245939 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01748863 0,06236255 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01748863 0,06226602 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,01748863 0,06216978 ! pericardium development GO:0060039 8 7 0,000 0,01748863 0,06207384 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01748863 0,06197819 ! fibril organization GO:0043206 13 7 0,000 0,01748863 0,06188284 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01748863 0,06178778 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01748863 0,06169302 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01748863 0,06159854 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01748863 0,06150435 ! lipoprotein transport GO:0042953 9 7 0,000 0,01748863 0,06141045 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01748863 0,06131684 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01748863 0,06122351 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01748863 0,06113047 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01748863 0,0610377 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01748863 0,06094522 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01748863 0,06085302 ! chemosensory behavior GO:0007635 9 7 0,000 0,01748863 0,0607611 ! microtubule bundle formation GO:0001578 8 7 0,000 0,01748863 0,06066945 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,01748863 0,06057808 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01748863 0,06048699 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01748863 0,06039617 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01748863 0,06030562 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01748863 0,06021534 ! reflex GO:0060004 12 7 0,000 0,01748863 0,06012533 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01748863 0,06003559 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01748863 0,05994612 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01748863 0,05985691 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01748863 0,05976797 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01748863 0,0596793 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01748863 0,05959088 ! spinal cord patterning GO:0021511 7 7 0,000 0,01748863 0,05950273 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01748863 0,05941484 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,01748863 0,05932721 ! adrenal gland development GO:0030325 17 7 0,000 0,01748863 0,05923983 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01748863 0,05915272 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01748863 0,05906585 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01748863 0,05897925 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01748863 0,05889289 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01748863 0,05880679 ! endosome organization GO:0007032 10 7 0,000 0,01748863 0,05872094 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01748863 0,05863535 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01748863 0,05855 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01748863 0,05846489 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01748863 0,05838004 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01748863 0,05829543 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01748863 0,05821107 ! galactose metabolic process GO:0006012 10 7 0,000 0,01748863 0,05812695 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01748863 0,05804307 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01748863 0,05795943 ! organ growth GO:0035265 11 7 0,000 0,01748863 0,05787604 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,01748863 0,05779288 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,01748863 0,05770997 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01748863 0,05762729 ! retinol metabolic process GO:0042572 9 7 0,000 0,01748863 0,05754485 ! behavioral fear response GO:0001662 13 7 0,000 0,01748863 0,05746264 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,01748863 0,05738067 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01748863 0,05729893 ! rRNA modification GO:0000154 12 7 0,000 0,01748863 0,05721742 ! protein heterooligomerization GO:0051291 10 7 0,000 0,01748863 0,05713615 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01748863 0,0570551 ! response to UV-B GO:0010224 11 7 0,000 0,01748863 0,05697429 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01748863 0,0568937 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,01748863 0,05681334 ! intermediate filament organization GO:0045109 11 7 0,000 0,01748863 0,05673321 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,01748863 0,05665331 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01748863 0,05657362 ! fibrinolysis GO:0042730 9 7 0,000 0,01748863 0,05649417 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01748863 0,05641493 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01748863 0,05633592 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01748863 0,05625713 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01748863 0,05617856 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01748863 0,0561002 ! response to tropane GO:0014073 13 7 0,000 0,01748863 0,05602207 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01748863 0,05594415 ! melanosome localization GO:0032400 10 7 0,000 0,01748863 0,05586645 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01748863 0,05578897 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01748863 0,0557117 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,01748863 0,05563464 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01748863 0,0555578 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01748863 0,05548117 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01748863 0,05540475 ! mast cell activation GO:0045576 9 7 0,000 0,01748863 0,05532854 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01748863 0,05525254 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,01748863 0,05517674 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01748863 0,05510116 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01748863 0,05502578 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01748863 0,05495061 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01748863 0,05487564 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,01748863 0,05480088 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01748863 0,05472632 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01748863 0,05465197 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,01748863 0,05457781 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01748863 0,05450386 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01748863 0,0544301 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01748863 0,05435655 ! response to tumor cell GO:0002347 12 7 0,000 0,01748863 0,05428319 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01748863 0,05421004 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01748863 0,05413708 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01748863 0,05406431 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,01748863 0,05399174 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01748863 0,05391937 ! diuresis GO:0030146 12 7 0,000 0,01748863 0,05384718 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01748863 0,0537752 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01748863 0,0537034 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01748863 0,0536318 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01748863 0,05356038 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01748863 0,05348916 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01748863 0,05341812 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01748863 0,05334728 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01748863 0,05327662 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01748863 0,05320615 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01748863 0,05313586 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01748863 0,05306576 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01748863 0,05299585 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01748863 0,05292611 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01748863 0,05285657 ! ATP catabolic process GO:0006200 10 7 0,000 0,01748863 0,0527872 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01748863 0,05271802 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01748863 0,05264901 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,01748863 0,05258019 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01748863 0,05251155 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01748863 0,05244309 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01748863 0,0523748 ! muscle adaptation GO:0043500 12 7 0,000 0,01748863 0,05230669 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01748863 0,05223876 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01748863 0,05217101 ! retina homeostasis GO:0001895 9 7 0,000 0,01748863 0,05210343 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01748863 0,05203602 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,01748863 0,05196879 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01748863 0,05190174 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,01748863 0,05183485 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01748863 0,05176814 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01748863 0,0517016 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01748863 0,05163523 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,01768688 0,05215361 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,01768688 0,05208683 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,01810038 0,05323641 GO:0060348|bone development, ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,01851798 0,05439508 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,01851798 0,0543257 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,01936537 0,05673929 ! regulation of membrane potential GO:0042391 128 85 1,000 0,01936537 0,0566671 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,01936537 0,0565951 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,01979511 0,05777762 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,01996248 0,05819227 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,01996248 0,05811861 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,01996248 0,05804513 ! axon extension GO:0048675 11 8 0,000 0,01996248 0,05797184 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,01996248 0,05789874 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,01996248 0,05782582 ! associative learning GO:0008306 15 8 0,000 0,01996248 0,05775308 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,01996248 0,05768053 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,01996248 0,05760815 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,01996248 0,05753596 ! phosphate transport GO:0006817 10 8 0,000 0,01996248 0,05746395 ! N-glycan processing GO:0006491 12 8 0,000 0,01996248 0,05739212 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,01996248 0,05732047 ! UTP metabolic process GO:0046051 8 8 0,000 0,01996248 0,057249 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,01996248 0,05717771 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,01996248 0,05710659 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,01996248 0,05703565 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,01996248 0,05696489 ! succinate metabolic process GO:0006105 14 8 0,000 0,01996248 0,0568943 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,01996248 0,05682388 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,01996248 0,05675364 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,01996248 0,05668358 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,01996248 0,05661368 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,01996248 0,05654396 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,01996248 0,05647441 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,01996248 0,05640503 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,01996248 0,05633583 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01996248 0,05626679 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,01996248 0,05619792 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,01996248 0,05612922 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,01996248 0,05606068 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,01996248 0,05599231 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,01996248 0,05592411 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,01996248 0,05585608 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,01996248 0,05578821 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,01996248 0,05572051 ! astrocyte differentiation GO:0048708 16 8 0,000 0,01996248 0,05565297 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,01996248 0,05558559 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,01996248 0,05551838 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,01996248 0,05545133 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,01996248 0,05538444 GO:0006559|L-phenylalanine catabolic process, ! melanin metabolic process GO:0006582 12 8 0,000 0,01996248 0,05531771 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,01996248 0,05525114 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,01996248 0,05518473 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,01996248 0,05511849 ! macrophage activation GO:0042116 12 8 0,000 0,01996248 0,0550524 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,01996248 0,05498646 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,01996248 0,05492069 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,01996248 0,05485508 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,01996248 0,05478962 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01996248 0,05472431 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,01996248 0,05465916 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,01996248 0,05459417 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,01996248 0,05452933 ! osteoblast development GO:0002076 13 8 0,000 0,01996248 0,05446465 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,01996248 0,05440012 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,01996248 0,05433574 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,01996248 0,05427151 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,01996248 0,05420744 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,01996248 0,05414351 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,01996248 0,05407974 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,01996248 0,05401612 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,01996248 0,05395264 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,01996248 0,05388932 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,01996248 0,05382614 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,01996248 0,05376311 ! oligodendrocyte development GO:0014003 8 8 0,000 0,01996248 0,05370023 ! segment specification GO:0007379 10 8 0,000 0,01996248 0,0536375 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,01996248 0,05357491 ! cellular extravasation GO:0045123 11 8 0,000 0,01996248 0,05351247 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,01996248 0,05345017 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,01996248 0,05338802 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,01996248 0,05332601 ! snRNA metabolic process GO:0016073 10 8 0,000 0,01996248 0,05326415 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,01996248 0,05320243 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,01996248 0,05314085 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,01996248 0,05307942 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,01996248 0,05301813 ! nucleosome disassembly GO:0006337 12 8 0,000 0,01996248 0,05295698 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,01996248 0,05289597 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,01996248 0,0528351 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,01996248 0,05277437 ! icosanoid secretion GO:0032309 12 8 0,000 0,01996248 0,05271378 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,01996248 0,05265332 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,01996248 0,05259301 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,01996248 0,05253284 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,01996248 0,0524728 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,01996248 0,0524129 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,01996248 0,05235313 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,01996248 0,05229351 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,01996248 0,05223401 ! sterol catabolic process GO:0016127 9 8 0,000 0,01996248 0,05217466 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,01996248 0,05211543 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,01996248 0,05205635 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,01996248 0,05199739 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,01996248 0,05193857 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,01996248 0,05187988 ! prophase GO:0051324 11 8 0,000 0,01996248 0,05182133 ! S phase GO:0051320 8 8 0,000 0,01996248 0,05176291 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,01996248 0,05170461 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,01996248 0,05164645 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,01996248 0,05158842 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,01996248 0,05153053 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,01996248 0,05147276 ! hormone catabolic process GO:0042447 13 8 0,000 0,01996248 0,05141512 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,01996248 0,0513576 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,01996248 0,05130022 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,01996248 0,05124297 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,01996248 0,05118584 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,01996248 0,05112884 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,01996248 0,05107197 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,01996248 0,05101522 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,01996248 0,0509586 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,01996248 0,0509021 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,01996248 0,05084573 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,01996248 0,05078949 ! regulation of embryonic development GO:0045995 16 8 0,000 0,01996248 0,05073337 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,01996248 0,05067737 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,01996248 0,0506215 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,01996248 0,05056575 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,02022887 0,05118416 GO:0060538|skeletal muscle organ development, ! interphase GO:0051325 159 88 1,000 0,02066661 0,05223428 ! regulation of T cell activation GO:0050863 128 89 1,000 0,02110831 0,05329211 ! leukocyte differentiation GO:0002521 143 90 1,000 0,02155395 0,05435755 ! response to virus GO:0009615 122 91 1,000 0,02200351 0,05543053 ! regulation of developmental growth GO:0048638 13 9 0,000 0,02243024 0,05644371 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,02243024 0,05638202 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02243024 0,05632047 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02243024 0,05625905 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02243024 0,05619776 ! CTP metabolic process GO:0046036 9 9 0,000 0,02243024 0,05613661 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02243024 0,0560756 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02243024 0,05601471 ! GTP metabolic process GO:0046039 9 9 0,000 0,02243024 0,05595396 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02243024 0,05589333 ! social behavior GO:0035176 14 9 0,000 0,02243024 0,05583284 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02243024 0,05577248 ! artery development GO:0060840 19 9 0,000 0,02243024 0,05571225 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02243024 0,05565216 ! regulation of glycolysis GO:0006110 15 9 0,000 0,02243024 0,05559219 ! response to pain GO:0048265 16 9 0,000 0,02243024 0,05553234 ! protein complex disassembly GO:0043241 17 9 0,000 0,02243024 0,05547263 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02243024 0,05541305 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02243024 0,05535359 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02243024 0,05529426 ! lung alveolus development GO:0048286 17 9 0,000 0,02243024 0,05523506 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02243024 0,05517599 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02243024 0,05511704 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02243024 0,05505822 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02243024 0,05499952 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02243024 0,05494095 ! protein targeting to ER GO:0045047 19 9 0,000 0,02243024 0,0548825 ! T cell selection GO:0045058 18 9 0,000 0,02243024 0,05482417 ! endoderm development GO:0007492 12 9 0,000 0,02243024 0,05476597 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02243024 0,0547079 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02243024 0,05464994 ! arginine catabolic process GO:0006527 10 9 0,000 0,02243024 0,05459211 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02243024 0,05453441 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02243024 0,05447682 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02243024 0,05441935 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02243024 0,05436201 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02243024 0,05430479 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02243024 0,05424768 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02243024 0,0541907 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02243024 0,05413384 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02243024 0,05407709 ! mannose metabolic process GO:0006013 9 9 0,000 0,02243024 0,05402047 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02243024 0,05396396 ! receptor clustering GO:0043113 15 9 0,000 0,02243024 0,05390757 ! epithelial cell development GO:0002064 10 9 0,000 0,02243024 0,0538513 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02243024 0,05379515 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02243024 0,05373911 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02243024 0,05368319 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02243024 0,05362739 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02243024 0,0535717 ! motor axon guidance GO:0008045 14 9 0,000 0,02243024 0,05351613 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02243024 0,05346067 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02243024 0,05340533 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02243024 0,0533501 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02243024 0,05329499 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02243024 0,05323999 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02243024 0,0531851 ! DNA ligation GO:0006266 14 9 0,000 0,02243024 0,05313033 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02243024 0,05307567 ! response to amine stimulus GO:0014075 13 9 0,000 0,02243024 0,05302112 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02243024 0,05296668 ! erythrocyte development GO:0048821 11 9 0,000 0,02243024 0,05291236 ! renal water homeostasis GO:0003091 14 9 0,000 0,02243024 0,05285814 ! postreplication repair GO:0006301 11 9 0,000 0,02243024 0,05280404 ! mRNA cleavage GO:0006379 13 9 0,000 0,02243024 0,05275005 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02243024 0,05269617 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02243024 0,0526424 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02243024 0,05258873 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02243024 0,05253518 ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02243024 0,05248174 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02243024 0,0524284 ! acid secretion GO:0046717 14 9 0,000 0,02243024 0,05237518 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02243024 0,05232206 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02243024 0,05226905 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02243024 0,05221614 ! purine base metabolic process GO:0006144 18 9 0,000 0,02243024 0,05216334 ! oocyte differentiation GO:0009994 12 9 0,000 0,02243024 0,05211065 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02243024 0,05205807 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02243024 0,05200559 ! spleen development GO:0048536 15 9 0,000 0,02243024 0,05195322 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02243024 0,05190095 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02243024 0,05184879 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02243024 0,05179673 ! detection of calcium ion GO:0005513 13 9 0,000 0,02243024 0,05174478 ! blastocyst formation GO:0001825 12 9 0,000 0,02243024 0,05169293 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02243024 0,05164119 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02243024 0,05158955 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02243024 0,05153801 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02243024 0,05148657 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02243024 0,05143524 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02243024 0,05138401 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02243024 0,05133288 ! prepulse inhibition GO:0060134 14 9 0,000 0,02243024 0,05128186 ! embryonic placenta development GO:0001892 12 9 0,000 0,02243024 0,05123093 ! insulin secretion GO:0030073 17 9 0,000 0,02243024 0,05118011 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02243024 0,05112938 ! response to nicotine GO:0035094 16 9 0,000 0,02243024 0,05107876 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02243024 0,05102824 ! nucleus localization GO:0051647 15 9 0,000 0,02243024 0,05097781 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02243024 0,05092749 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,02245697 0,05093789 ! cell fate commitment GO:0045165 141 92 1,000 0,02245697 0,05088771 ! angiogenesis GO:0001525 149 95 1,000 0,02384051 0,05396966 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,02430934 0,05497688 ! in utero embryonic development GO:0001701 147 96 1,000 0,02430934 0,05492288 ! response to light stimulus GO:0009416 153 96 1,000 0,02430934 0,05486898 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02489193 0,05612885 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02489193 0,05607388 ! neuron fate specification GO:0048665 11 10 0,000 0,02489193 0,05601901 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02489193 0,05596425 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02489193 0,0559096 ! thyroid gland development GO:0030878 19 10 0,000 0,02489193 0,05585505 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,02489193 0,05580061 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02489193 0,05574628 ! synapsis GO:0007129 13 10 0,000 0,02489193 0,05569205 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02489193 0,05563793 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02489193 0,05558391 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02489193 0,05553 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02489193 0,05547619 ! sulfate transport GO:0008272 12 10 0,000 0,02489193 0,05542249 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02489193 0,05536889 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02489193 0,05531539 ! androgen metabolic process GO:0008209 13 10 0,000 0,02489193 0,055262 ! phospholipid efflux GO:0033700 16 10 0,000 0,02489193 0,05520871 ! hippocampus development GO:0021766 19 10 0,000 0,02489193 0,05515552 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02489193 0,05510243 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02489193 0,05504945 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02489193 0,05499657 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02489193 0,05494379 ! pathogenesis GO:0009405 13 10 0,000 0,02489193 0,05489111 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02489193 0,05483853 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02489193 0,05478606 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02489193 0,05473368 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02489193 0,0546814 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02489193 0,05462923 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02489193 0,05457715 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02489193 0,05452517 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02489193 0,05447329 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02489193 0,05442151 GO:0005978|glycogen biosynthetic process, ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02489193 0,05436983 ! response to X-ray GO:0010165 16 10 0,000 0,02489193 0,05431824 ! B cell proliferation GO:0042100 14 10 0,000 0,02489193 0,05426676 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02489193 0,05421537 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02489193 0,05416408 ! forebrain cell migration GO:0021885 17 10 0,000 0,02489193 0,05411288 ! lipid digestion GO:0044241 15 10 0,000 0,02489193 0,05406178 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02489193 0,05401078 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02489193 0,05395988 ! UV protection GO:0009650 14 10 0,000 0,02489193 0,05390907 ! entry into host cell GO:0030260 20 10 0,000 0,02489193 0,05385835 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02489193 0,05380773 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02489193 0,05375721 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02489193 0,05370678 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02489193 0,05365645 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02489193 0,05360621 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02489193 0,05355606 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02489193 0,05350601 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02489193 0,05345605 ! regulation of organ growth GO:0046620 11 10 0,000 0,02489193 0,05340618 ! response to dsRNA GO:0043331 18 10 0,000 0,02489193 0,05335641 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02489193 0,05330673 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02489193 0,05325714 ! embryonic axis specification GO:0000578 12 10 0,000 0,02489193 0,05320765 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02489193 0,05315824 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02489193 0,05310893 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02489193 0,05305971 ! cranial nerve development GO:0021545 12 10 0,000 0,02489193 0,05301058 ! fucose catabolic process GO:0019317 16 10 0,000 0,02489193 0,05296154 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02489193 0,0529126 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02489193 0,05286374 ! protein sumoylation GO:0016925 12 10 0,000 0,02489193 0,05281497 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02489193 0,05276629 ! zymogen activation GO:0031638 14 10 0,000 0,02489193 0,05271771 ! salivary gland development GO:0007431 22 10 0,000 0,02489193 0,05266921 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02489193 0,0526208 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02489193 0,05257248 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02489193 0,05252425 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02489193 0,0524761 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02489193 0,05242805 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02489193 0,05238008 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02489193 0,0523322 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02489193 0,05228441 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02489193 0,05223671 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,02489193 0,05218909 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02489193 0,05214156 ! detection of bacterium GO:0016045 10 10 0,000 0,02489193 0,05209411 ! embryonic gut development GO:0048566 11 10 0,000 0,02489193 0,05204675 ! activation of innate immune response GO:0002218 10 10 0,000 0,02489193 0,05199948 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02489193 0,0519523 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02489193 0,05190519 ! developmental induction GO:0031128 13 10 0,000 0,02489193 0,05185818 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02489193 0,05181125 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02489193 0,0517644 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02489193 0,05171764 ! calcium ion transport GO:0006816 167 99 1,000 0,0257385 0,05342829 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,02622237 0,05438363 ! divalent metal ion transport GO:0070838 171 100 1,000 0,02622237 0,05433464 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,02622237 0,05428573 ! rRNA transcription GO:0009303 17 11 0,000 0,02734756 0,05656419 ! respiratory burst GO:0045730 14 11 0,000 0,02734756 0,05651337 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,02734756 0,05646264 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,02734756 0,056412 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,02734756 0,05636145 ! virus-host interaction GO:0019048 17 11 0,000 0,02734756 0,05631099 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,02734756 0,05626062 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,02734756 0,05621035 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,02734756 0,05616016 ! RNA polyadenylation GO:0043631 19 11 0,000 0,02734756 0,05611006 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,02734756 0,05606005 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,02734756 0,05601013 ! mating GO:0007618 14 11 0,000 0,02734756 0,0559603 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,02734756 0,05591056 ! T cell proliferation GO:0042098 20 11 0,000 0,02734756 0,0558609 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,02734756 0,05581134 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,02734756 0,05576186 ! bone resorption GO:0045453 16 11 0,000 0,02734756 0,05571247 ! regulated secretory pathway GO:0045055 14 11 0,000 0,02734756 0,05566317 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,02734756 0,05561395 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,02734756 0,05556482 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,02734756 0,05551578 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,02734756 0,05546682 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,02734756 0,05541795 ! syncytium formation GO:0006949 15 11 0,000 0,02734756 0,05536917 ! plasma membrane organization GO:0007009 18 11 0,000 0,02734756 0,05532047 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,02734756 0,05527186 ! focal adhesion formation GO:0048041 24 11 0,000 0,02734756 0,05522333 ! mitotic spindle organization GO:0007052 15 11 0,000 0,02734756 0,05517489 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,02734756 0,05512654 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,02734756 0,05507826 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,02734756 0,05503008 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,02734756 0,05498197 ! adult heart development GO:0007512 11 11 0,000 0,02734756 0,05493395 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,02734756 0,05488602 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,02734756 0,05483817 ! temperature homeostasis GO:0001659 16 11 0,000 0,02734756 0,0547904 ! L-glutamate transport GO:0015813 16 11 0,000 0,02734756 0,05474271 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,02734756 0,05469511 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,02734756 0,05464759 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,02734756 0,05460015 ! stem cell development GO:0048864 29 11 0,000 0,02734756 0,0545528 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,02734756 0,05450553 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,02734756 0,05445833 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,02734756 0,05441123 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,02734756 0,0543642 ! vasoconstriction GO:0042310 15 11 0,000 0,02734756 0,05431725 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,02734756 0,05427039 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,02734756 0,0542236 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,02734756 0,0541769 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,02734756 0,05413027 ! ribosome assembly GO:0042255 13 11 0,000 0,02734756 0,05408373 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,02734756 0,05403727 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,02734756 0,05399088 ! nucleosome positioning GO:0016584 13 11 0,000 0,02734756 0,05394458 ! T cell homeostasis GO:0043029 20 11 0,000 0,02734756 0,05389835 ! regulation of isotype switching GO:0045191 19 11 0,000 0,02734756 0,05385221 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,02734756 0,05380614 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,02734756 0,05376015 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,02734756 0,05371424 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,02734756 0,05366841 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,02734756 0,05362266 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,02734756 0,05357698 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,02734756 0,05353138 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,02734756 0,05348586 ! male genitalia development GO:0030539 13 11 0,000 0,02734756 0,05344042 ! cholesterol efflux GO:0033344 19 11 0,000 0,02734756 0,05339506 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,02734756 0,05334977 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,02734756 0,05330456 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,02734756 0,05325942 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,02734756 0,05321436 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,02734756 0,05316938 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,02734756 0,05312447 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,02734756 0,05307964 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,02734756 0,05303489 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,02734756 0,05299021 ! lysogeny GO:0030069 18 11 0,000 0,02734756 0,0529456 GO:0019047|provirus integration, ! acrosome reaction GO:0007340 13 11 0,000 0,02734756 0,05290107 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,02734756 0,05285662 ! lactation GO:0007595 20 12 0,000 0,02979714 0,05754276 ! reproductive cellular process GO:0048610 14 12 0,000 0,02979714 0,05749448 ! tRNA modification GO:0006400 14 12 0,000 0,02979714 0,05744629 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,02979714 0,05739818 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,02979714 0,05735015 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,02979714 0,05730219 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,02979714 0,05725432 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,02979714 0,05720653 ! non-recombinational repair GO:0000726 19 12 0,000 0,02979714 0,05715882 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,02979714 0,05711119 ! peroxisomal transport GO:0043574 21 12 0,000 0,02979714 0,05706363 ! cartilage condensation GO:0001502 18 12 0,000 0,02979714 0,05701616 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,02979714 0,05696876 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,02979714 0,05692145 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,02979714 0,05687421 ! heart looping GO:0001947 15 12 0,000 0,02979714 0,05682705 ! palate development GO:0060021 15 12 0,000 0,02979714 0,05677997 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,02979714 0,05673297 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,02979714 0,05668604 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,02979714 0,05663919 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,02979714 0,05659242 ! arginine metabolic process GO:0006525 13 12 0,000 0,02979714 0,05654573 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,02979714 0,05649911 ! methionine metabolic process GO:0006555 13 12 0,000 0,02979714 0,05645257 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,02979714 0,05640611 ! Golgi organization GO:0007030 18 12 0,000 0,02979714 0,05635972 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,02979714 0,05631341 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,02979714 0,05626718 ! monoamine transport GO:0015844 13 12 0,000 0,02979714 0,05622102 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02979714 0,05617494 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,02979714 0,05612893 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,02979714 0,056083 ! L-amino acid transport GO:0015807 20 12 0,000 0,02979714 0,05603714 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,02979714 0,05599136 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,02979714 0,05594565 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,02979714 0,05590002 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,02979714 0,05585446 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,02979714 0,05580898 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,02979714 0,05576357 ! cerebellum development GO:0021549 13 12 0,000 0,02979714 0,05571823 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,02979714 0,05567297 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,02979714 0,05562778 ! histone acetylation GO:0016573 23 12 0,000 0,02979714 0,05558266 ! histone methylation GO:0016571 15 12 0,000 0,02979714 0,05553762 ! autonomic nervous system development GO:0048483 23 12 0,000 0,02979714 0,05549265 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,02979714 0,05544775 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,02979714 0,05540293 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,02979714 0,05535818 ! response to gamma radiation GO:0010332 20 12 0,000 0,02979714 0,0553135 ! regulation of epidermis development GO:0045682 17 12 0,000 0,02979714 0,05526889 ! intestinal absorption GO:0050892 19 12 0,000 0,02979714 0,05522435 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,02979714 0,05517989 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,02979714 0,0551355 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,02979714 0,05509118 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,02979714 0,05504693 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,02979714 0,05500275 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,02979714 0,05495864 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,02979714 0,0549146 ! microspike assembly GO:0030035 23 12 0,000 0,02979714 0,05487064 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,02979714 0,05482674 ! response to cold GO:0009409 14 12 0,000 0,02979714 0,05478291 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,0322407 0,05922812 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,0322407 0,05918085 ! cGMP metabolic process GO:0046068 16 13 0,000 0,0322407 0,05913365 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,0322407 0,05908654 ! water transport GO:0006833 17 13 0,000 0,0322407 0,05903949 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,0322407 0,05899252 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,0322407 0,05894563 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,0322407 0,05889881 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,0322407 0,05885207 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,0322407 0,05880539 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,0322407 0,0587588 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,0322407 0,05871227 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,0322407 0,05866582 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,0322407 0,05861945 ! response to hexose stimulus GO:0009746 19 13 0,000 0,0322407 0,05857315 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,0322407 0,05852692 ! glutamate metabolic process GO:0006536 18 13 0,000 0,0322407 0,05848076 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,0322407 0,05843468 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,0322407 0,05838866 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,0322407 0,05834272 ! NAD metabolic process GO:0019674 21 13 0,000 0,0322407 0,05829686 ! exocrine system development GO:0035272 27 13 0,000 0,0322407 0,05825106 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,0322407 0,05820534 ! bone mineralization GO:0030282 15 13 0,000 0,0322407 0,05815969 ! regulation of exocytosis GO:0017157 17 13 0,000 0,0322407 0,05811411 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,0322407 0,0580686 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,0322407 0,05802316 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,0322407 0,0579778 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,0322407 0,0579325 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,0322407 0,05788728 ! genitalia development GO:0048806 15 13 0,000 0,0322407 0,05784212 ! regulation of cellular pH GO:0030641 20 13 0,000 0,0322407 0,05779704 ! cellular pigmentation GO:0033059 24 13 0,000 0,0322407 0,05775203 ! tissue regeneration GO:0042246 21 13 0,000 0,0322407 0,05770708 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,0322407 0,05766221 ! cofactor transport GO:0051181 19 13 0,000 0,0322407 0,05761741 ! NADP metabolic process GO:0006739 18 13 0,000 0,0322407 0,05757267 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,0322407 0,05752801 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,0322407 0,05748341 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,0322407 0,05743889 ! gas transport GO:0015669 18 13 0,000 0,0322407 0,05739443 ! regulation of RNA stability GO:0043487 28 13 0,000 0,0322407 0,05735004 ! heme biosynthetic process GO:0006783 20 13 0,000 0,0322407 0,05730572 ! regulation of axon extension GO:0030516 23 13 0,000 0,0322407 0,05726147 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,0322407 0,05721729 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,0322407 0,05717317 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,0322407 0,05712912 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,0322407 0,05708514 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,0322407 0,05704123 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,0322407 0,05699739 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,03467824 0,06125956 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,03467824 0,06121255 ! superoxide anion generation GO:0042554 18 14 0,000 0,03467824 0,0611656 ! neuron maturation GO:0042551 21 14 0,000 0,03467824 0,06111873 ! regulation of S phase GO:0033261 18 14 0,000 0,03467824 0,06107194 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,03467824 0,06102521 ! myotube differentiation GO:0014902 21 14 0,000 0,03467824 0,06097855 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,03467824 0,06093197 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,03467824 0,06088546 ! inositol metabolic process GO:0006020 20 14 0,000 0,03467824 0,06083901 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,03467824 0,06079264 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,03467824 0,06074634 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,03467824 0,06070011 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,03467824 0,06065395 ! gene silencing by RNA GO:0031047 20 14 0,000 0,03467824 0,06060786 ! response to cAMP GO:0051591 19 14 0,000 0,03467824 0,06056184 ! limbic system development GO:0021761 25 14 0,000 0,03467824 0,06051589 ! startle response GO:0001964 21 14 0,000 0,03467824 0,06047001 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,03467824 0,0604242 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,03467824 0,06037846 ! glycine metabolic process GO:0006544 22 14 0,000 0,03467824 0,06033279 ! pituitary gland development GO:0021983 23 14 0,000 0,03467824 0,06028719 ! cellular response to starvation GO:0009267 21 14 0,000 0,03467824 0,06024165 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,03467824 0,06019619 GO:0031114|regulation of microtubule depolymerization, ! regulation of heart rate GO:0002027 23 14 0,000 0,03467824 0,06015079 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,03467824 0,06010546 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,03467824 0,0600602 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,03467824 0,06001501 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,03467824 0,05996989 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,03467824 0,05992483 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,03467824 0,05987984 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,03467824 0,05983492 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,03467824 0,05979007 ! axon cargo transport GO:0008088 27 14 0,000 0,03467824 0,05974528 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,03467824 0,05970056 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,03467824 0,05965591 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,03467824 0,05961132 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,03467824 0,0595668 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03467824 0,05952235 ! mRNA splice site selection GO:0006376 26 14 0,000 0,03467824 0,05947796 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,03467824 0,05943364 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,03467824 0,05938939 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,03467824 0,0593452 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,03467824 0,05930108 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,03467824 0,05925702 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,03467824 0,05921303 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,03467824 0,0591691 ! muscle maintenance GO:0046716 19 14 0,000 0,03467824 0,05912524 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,03467824 0,05908144 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,03467824 0,05903771 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,03467824 0,05899404 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,03467824 0,05895044 ! cell killing GO:0001906 20 14 0,000 0,03467824 0,0589069 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,03467824 0,05886343 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,03467824 0,05882002 ! cilium assembly GO:0042384 20 14 0,000 0,03467824 0,05877667 ! peptide hormone secretion GO:0030072 23 14 0,000 0,03467824 0,05873339 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,03710978 0,06280537 ! positive regulation of cell size GO:0045793 20 15 0,000 0,03710978 0,06275919 ! metencephalon development GO:0022037 19 15 0,000 0,03710978 0,06271307 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,03710978 0,06266703 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,03710978 0,06262105 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,03710978 0,06257514 ! skin development GO:0043588 25 15 0,000 0,03710978 0,0625293 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,03710978 0,06248352 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,03710978 0,06243781 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,03710978 0,06239217 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,03710978 0,0623466 ! bile acid metabolic process GO:0008206 22 15 0,000 0,03710978 0,06230109 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,03710978 0,06225565 ! adult walking behavior GO:0007628 25 15 0,000 0,03710978 0,06221027 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,03710978 0,06216496 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,03710978 0,06211972 ! myoblast differentiation GO:0045445 27 15 0,000 0,03710978 0,06207454 ! centrosome cycle GO:0007098 16 15 0,000 0,03710978 0,06202943 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,03710978 0,06198438 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,03710978 0,0619394 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,03710978 0,06189448 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,03710978 0,06184963 ! cerebral cortex development GO:0021987 29 15 0,000 0,03710978 0,06180485 ! response to osmotic stress GO:0006970 22 15 0,000 0,03710978 0,06176012 ! vesicle coating GO:0006901 25 15 0,000 0,03710978 0,06171547 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,03710978 0,06167088 ! DNA integration GO:0015074 22 15 0,000 0,03710978 0,06162635 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,03710978 0,06158188 ! peptide secretion GO:0002790 27 15 0,000 0,03710978 0,06153749 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,03710978 0,06149315 ! neuron recognition GO:0008038 22 15 0,000 0,03710978 0,06144888 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,03710978 0,06140467 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,03710978 0,06136053 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,03710978 0,06131645 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,03710978 0,06127243 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,03710978 0,06122847 ! biomineral formation GO:0031214 18 15 0,000 0,03710978 0,06118458 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,03710978 0,06114075 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,03710978 0,06109699 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,03710978 0,06105328 ! dopamine metabolic process GO:0042417 30 15 0,000 0,03710978 0,06100964 ! organic cation transport GO:0015695 19 15 0,000 0,03710978 0,06096607 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,03710978 0,06092255 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,03710978 0,0608791 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,03710978 0,0608357 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,03710978 0,06079237 ! defense response to virus GO:0051607 27 15 0,000 0,03710978 0,0607491 ! peptide hormone processing GO:0016486 19 15 0,000 0,03710978 0,0607059 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,03710978 0,06066275 ! protein secretion GO:0009306 27 16 0,000 0,03953533 0,06458187 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,03953533 0,06453603 ! hormone secretion GO:0046879 25 16 0,000 0,03953533 0,06449026 ! bone remodeling GO:0046849 24 16 0,000 0,03953533 0,06444456 ! endothelial cell migration GO:0043542 22 16 0,000 0,03953533 0,06439892 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,03953533 0,06435334 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,03953533 0,06430783 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,03953533 0,06426238 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,03953533 0,064217 ! glial cell development GO:0021782 24 16 0,000 0,03953533 0,06417168 ! patterning of blood vessels GO:0001569 24 16 0,000 0,03953533 0,06412642 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,03953533 0,06408123 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,03953533 0,0640361 ! protein polyubiquitination GO:0000209 26 16 0,000 0,03953533 0,06399104 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,03953533 0,06394604 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,03953533 0,0639011 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,03953533 0,06385623 ! fructose metabolic process GO:0006000 20 16 0,000 0,03953533 0,06381142 ! regulation of protein binding GO:0043393 27 16 0,000 0,03953533 0,06376667 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,03953533 0,06372198 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,03953533 0,06367736 ! protein export from nucleus GO:0006611 24 16 0,000 0,03953533 0,0636328 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,03953533 0,0635883 ! DNA replication initiation GO:0006270 25 16 0,000 0,03953533 0,06354386 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,03953533 0,06349949 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,03953533 0,06345518 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,03953533 0,06341093 ! diencephalon development GO:0021536 25 16 0,000 0,03953533 0,06336674 ! oogenesis GO:0048477 23 16 0,000 0,03953533 0,06332261 ! neural crest cell migration GO:0001755 24 16 0,000 0,03953533 0,06327854 ! G1 phase GO:0051318 27 16 0,000 0,03953533 0,06323454 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,03953533 0,0631906 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,03953533 0,06314671 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,03953533 0,06310289 ! steroid catabolic process GO:0006706 22 16 0,000 0,03953533 0,06305913 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,03953533 0,06301543 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,03953533 0,06297179 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,03953533 0,06292821 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,03953533 0,06288469 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,03953533 0,06284124 ! sperm-egg recognition GO:0035036 16 16 0,000 0,03953533 0,06279784 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,03953533 0,0627545 ! nerve development GO:0021675 18 16 0,000 0,03953533 0,06271122 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,03953533 0,062668 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,03953533 0,06262484 ! negative regulation of translation GO:0017148 22 16 0,000 0,03953533 0,06258174 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,04195492 0,0663661 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,04195492 0,06632049 ! negative regulation of defense response GO:0031348 19 17 0,000 0,04195492 0,06627494 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,04195492 0,06622945 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,04195492 0,06618403 ! glycerol metabolic process GO:0006071 20 17 0,000 0,04195492 0,06613866 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,04195492 0,06609336 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,04195492 0,06604812 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,04195492 0,06600295 ! signal complex assembly GO:0007172 29 17 0,000 0,04195492 0,06595783 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,04195492 0,06591278 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,04195492 0,06586779 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,04195492 0,06582286 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,04195492 0,06577799 ! memory GO:0007613 25 17 0,000 0,04195492 0,06573318 ! keratinization GO:0031424 17 17 0,000 0,04195492 0,06568843 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,04195492 0,06564375 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,04195492 0,06559912 ! retinoid metabolic process GO:0001523 22 17 0,000 0,04195492 0,06555456 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,04195492 0,06551005 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,04195492 0,06546561 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,04195492 0,06542123 GO:0032392|DNA geometric change, ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,04195492 0,0653769 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,04195492 0,06533264 ! membrane budding GO:0006900 29 17 0,000 0,04195492 0,06528844 ! heme metabolic process GO:0042168 27 17 0,000 0,04195492 0,06524429 ! actin filament bundle formation GO:0051017 26 17 0,000 0,04195492 0,06520021 ! neuromuscular junction development GO:0007528 23 17 0,000 0,04195492 0,06515619 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,04195492 0,06511222 ! body fluid secretion GO:0007589 27 17 0,000 0,04195492 0,06506831 ! stem cell differentiation GO:0048863 36 17 0,000 0,04195492 0,06502447 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,04195492 0,06498068 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,04195492 0,06493695 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,04195492 0,06489328 ! sensory perception of pain GO:0019233 23 17 0,000 0,04195492 0,06484967 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,04195492 0,06480612 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,04195492 0,06476262 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,04195492 0,06471919 ! synaptogenesis GO:0007416 24 17 0,000 0,04195492 0,06467581 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,04195492 0,06463249 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,04195492 0,06458923 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,04195492 0,06454603 ! cell-cell junction organization GO:0045216 25 17 0,000 0,04195492 0,06450288 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,04195492 0,06445979 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,04195492 0,06441676 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,04195492 0,06437379 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,04195492 0,06433087 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,04195492 0,06428801 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,04195492 0,06424521 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,04436854 0,06789598 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,04436854 0,06785083 ! positive regulation of translation GO:0045727 28 18 0,000 0,04436854 0,06780575 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,04436854 0,06776072 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,04436854 0,06771576 ! cAMP metabolic process GO:0046058 33 18 0,000 0,04436854 0,06767086 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,04436854 0,06762601 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,04436854 0,06758123 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,04436854 0,0675365 ! axis specification GO:0009798 26 18 0,000 0,04436854 0,06749183 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,04436854 0,06744722 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,04436854 0,06740268 ! pancreas development GO:0031016 26 18 0,000 0,04436854 0,06735819 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,04436854 0,06731375 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,04436854 0,06726938 ! glutamine metabolic process GO:0006541 23 18 0,000 0,04436854 0,06722507 ! response to retinoic acid GO:0032526 25 18 0,000 0,04436854 0,06718081 ! pigmentation during development GO:0048066 31 18 0,000 0,04436854 0,06713661 ! central nervous system neuron development GO:0021954 30 18 0,000 0,04436854 0,06709247 ! fucose metabolic process GO:0006004 26 18 0,000 0,04436854 0,06704839 ! response to fungus GO:0009620 19 18 0,000 0,04436854 0,06700437 ! peptide cross-linking GO:0018149 31 18 0,000 0,04436854 0,0669604 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,04436854 0,06691649 ! heart process GO:0003015 27 18 0,000 0,04436854 0,06687264 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,04436854 0,06682885 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,04436854 0,06678511 ! visual learning GO:0008542 35 18 0,000 0,04436854 0,06674143 ! somitogenesis GO:0001756 24 18 0,000 0,04436854 0,06669781 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,04436854 0,06665425 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,04436854 0,06661074 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,04436854 0,06656729 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,04436854 0,06652389 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,04436854 0,06648055 ! vitamin transport GO:0051180 24 18 0,000 0,04436854 0,06643727 ! hormone transport GO:0009914 27 18 0,000 0,04436854 0,06639405 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,04436854 0,06635088 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,04436854 0,06630777 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,04436854 0,06626471 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,04436854 0,06622171 ! cell-cell recognition GO:0009988 20 18 0,000 0,04436854 0,06617876 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,04436854 0,06613587 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,04436854 0,06609304 ! regulation of glucose import GO:0046324 21 18 0,000 0,04436854 0,06605026 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,04436854 0,06600754 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,04436854 0,06596487 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,04436854 0,06592226 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,04436854 0,0658797 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,04677623 0,06940989 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,04677623 0,06936513 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,04677623 0,06932044 ! positive regulation of ossification GO:0045778 30 19 0,000 0,04677623 0,0692758 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,04677623 0,06923122 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,04677623 0,0691867 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,04677623 0,06914224 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,04677623 0,06909783 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,04677623 0,06905348 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,04677623 0,06900919 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,04677623 0,06896495 ! regeneration GO:0031099 32 19 0,000 0,04677623 0,06892077 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,04677623 0,06887665 ! response to alkaloid GO:0043279 32 19 0,000 0,04677623 0,06883258 ! sensory perception of taste GO:0050909 23 19 0,000 0,04677623 0,06878857 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,04677623 0,06874462 ! smooth muscle contraction GO:0006939 36 19 0,000 0,04677623 0,06870072 ! peroxisome organization GO:0007031 29 19 0,000 0,04677623 0,06865687 ! digestive system process GO:0022600 30 19 0,000 0,04677623 0,06861309 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,04677623 0,06856936 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,04677623 0,06852568 ! response to vitamin A GO:0033189 26 19 0,000 0,04677623 0,06848206 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,04677623 0,0684385 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,04677623 0,06839499 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,04677623 0,06835154 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,04677623 0,06830814 ! response to starvation GO:0042594 30 19 0,000 0,04677623 0,0682648 ! sex determination GO:0007530 29 19 0,000 0,04677623 0,06822151 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,04677623 0,06817828 ! plasma membrane fusion GO:0045026 23 19 0,000 0,04677623 0,0681351 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,04677623 0,06809198 ! cytolysis GO:0019835 20 19 0,000 0,04677623 0,06804891 ! renal system process GO:0003014 35 19 0,000 0,04677623 0,06800589 ! vasodilation GO:0042311 33 19 0,000 0,04677623 0,06796293 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,04677623 0,06792003 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,04677623 0,06787718 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,04677623 0,06783438 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,04677623 0,06779163 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,04677623 0,06774894 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,04677623 0,06770631 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,04677623 0,06766373 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,04677623 0,0676212 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,04677623 0,06757872 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,04677623 0,0675363 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,04677623 0,06749393 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,04677623 0,06745161 ! protein stabilization GO:0050821 26 19 0,000 0,04677623 0,06740935 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,04917798 0,07082615 ! iron ion transport GO:0006826 37 20 0,000 0,04917798 0,07078183 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,04917798 0,07073756 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,04917798 0,07069335 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,04917798 0,07064919 ! response to vitamin GO:0033273 29 20 0,000 0,04917798 0,07060509 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,04917798 0,07056105 ! spinal cord development GO:0021510 31 20 0,000 0,04917798 0,07051706 ! response to ethanol GO:0045471 37 20 0,000 0,04917798 0,07047312 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,04917798 0,07042924 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,04917798 0,07038541 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,04917798 0,07034164 ! chromosome condensation GO:0030261 31 20 0,000 0,04917798 0,07029792 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,04917798 0,07025426 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,04917798 0,07021065 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,04917798 0,0701671 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,04917798 0,0701236 ! pallium development GO:0021543 38 20 0,000 0,04917798 0,07008015 ! DNA modification GO:0006304 28 20 0,000 0,04917798 0,07003675 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,04917798 0,06999342 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,04917798 0,06995013 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,04917798 0,0699069 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,04917798 0,06986372 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,04917798 0,06982059 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,04917798 0,06977752 ! collagen catabolic process GO:0030574 25 20 0,000 0,04917798 0,0697345 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,04917798 0,06969153 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,04917798 0,06964862 ! alditol metabolic process GO:0019400 24 20 0,000 0,04917798 0,06960576 ! actin filament-based movement GO:0030048 34 20 0,000 0,04917798 0,06956295 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,05157382 0,07290706 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,05157382 0,07286228 GO:0016444|somatic cell DNA recombination, ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,05157382 0,07281755 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,05157382 0,07277288 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,05157382 0,07272826 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,05157382 0,0726837 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,05157382 0,07263919 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,05157382 0,07259473 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,05157382 0,07255033 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,05157382 0,07250599 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,05157382 0,07246169 ! protein amino acid acylation GO:0043543 37 21 0,000 0,05157382 0,07241746 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,05157382 0,07237327 ! phototransduction GO:0007602 25 21 0,000 0,05157382 0,07232914 ! dendrite development GO:0016358 35 21 0,000 0,05157382 0,07228507 ! visual behavior GO:0007632 39 21 0,000 0,05157382 0,07224104 ! ovarian follicle development GO:0001541 30 21 0,000 0,05157382 0,07219707 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,05157382 0,07215316 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,05157382 0,0721093 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,05157382 0,07206549 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,05157382 0,07202173 ! cell aging GO:0007569 32 21 0,000 0,05157382 0,07197803 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,05157382 0,07193438 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,05157382 0,07189078 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,05157382 0,07184724 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,05157382 0,07180375 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,05157382 0,07176031 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,05157382 0,07171692 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,05157382 0,07167359 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,05157382 0,07163031 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,05157382 0,07158708 ! fatty acid transport GO:0015908 30 21 0,000 0,05157382 0,0715439 ! immunoglobulin production GO:0002377 33 21 0,000 0,05157382 0,07150078 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,05157382 0,07145771 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,05157382 0,07141469 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,05157382 0,07137172 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,05157382 0,0713288 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,05157382 0,07128593 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,05157382 0,07124312 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,05157382 0,07120036 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,05157382 0,07115764 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,05157382 0,07111498 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,05157382 0,07107237 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,05157382 0,07102982 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,05157382 0,07098731 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,05157382 0,07094485 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,05157382 0,07090245 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,05396376 0,07414376 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,05396376 0,0740995 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,05396376 0,07405528 ! viral genome replication GO:0019079 29 22 0,000 0,05396376 0,07401112 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,05396376 0,07396702 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,05396376 0,07392296 ! leukocyte adhesion GO:0007159 38 22 0,000 0,05396376 0,07387896 ! molting cycle process GO:0022404 40 22 0,000 0,05396376 0,07383501 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,05396376 0,07379112 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,05396376 0,07374727 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,05396376 0,07370348 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,05396376 0,07365974 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,05396376 0,07361605 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,05396376 0,07357241 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,05396376 0,07352882 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,05396376 0,07348529 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,05396376 0,07344181 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,05396376 0,07339838 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,05396376 0,073355 ! regulation of behavior GO:0050795 38 22 0,000 0,05396376 0,07331167 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,05396376 0,07326839 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,05396376 0,07322517 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,05396376 0,07318199 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,05396376 0,07313887 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,05396376 0,07309579 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,05396376 0,07305277 ! neural tube closure GO:0001843 33 22 0,000 0,05396376 0,0730098 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,05396376 0,07296688 ! protein tetramerization GO:0051262 39 22 0,000 0,05396376 0,072924 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,05634782 0,07610099 ! neuron fate commitment GO:0048663 32 23 0,000 0,05634782 0,07605633 ! embryonic pattern specification GO:0009880 31 23 0,000 0,05634782 0,07601172 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,05634782 0,07596716 ! myelination GO:0042552 35 23 0,000 0,05634782 0,07592266 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,05634782 0,07587821 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,05634782 0,07583381 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,05634782 0,07578946 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,05634782 0,07574517 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,05634782 0,07570092 ! vesicle targeting GO:0006903 32 23 0,000 0,05634782 0,07565673 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,05634782 0,07561259 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,05634782 0,0755685 ! osteoblast differentiation GO:0001649 40 23 0,000 0,05634782 0,07552446 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,05634782 0,07548048 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,05634782 0,07543654 ! interaction with host GO:0051701 37 23 0,000 0,05634782 0,07539266 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,05634782 0,07534883 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,05634782 0,07530504 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,05634782 0,07526131 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,05634782 0,07521763 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,05634782 0,075174 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,05634782 0,07513042 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,05634782 0,0750869 ! pentose metabolic process GO:0019321 31 23 0,000 0,05634782 0,07504342 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,05634782 0,07499999 ! spermatid development GO:0007286 33 23 0,000 0,05634782 0,07495661 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,05634782 0,07491328 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,05634782 0,07487001 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,05634782 0,07482678 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,05634782 0,0747836 ! telomere organization GO:0032200 32 23 0,000 0,05634782 0,07474047 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,05634782 0,0746974 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,05634782 0,07465437 ! regulation of amine transport GO:0051952 38 23 0,000 0,05634782 0,07461139 ! liver development GO:0001889 40 23 0,000 0,05634782 0,07456846 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,058726 0,07767096 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,058726 0,07762632 ! initiation of viral infection GO:0019059 42 24 0,000 0,058726 0,07758174 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,058726 0,0775372 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,058726 0,07749272 ! superoxide metabolic process GO:0006801 32 24 0,000 0,058726 0,07744828 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,058726 0,0774039 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,058726 0,07735957 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,058726 0,07731528 ! sperm motility GO:0030317 27 24 0,000 0,058726 0,07727105 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,058726 0,07722687 ! vacuole organization GO:0007033 39 24 0,000 0,058726 0,07718274 ! receptor metabolic process GO:0043112 37 24 0,000 0,058726 0,07713866 ! neural crest cell development GO:0014032 39 24 0,000 0,058726 0,07709464 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,058726 0,07705066 ! primary neural tube formation GO:0014020 35 24 0,000 0,058726 0,07700673 ! negative regulation of cell development GO:0010721 56 24 0,000 0,058726 0,07696285 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,058726 0,07691902 ! base-excision repair GO:0006284 31 24 0,000 0,058726 0,07687524 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,058726 0,07683151 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,058726 0,07678784 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,058726 0,07674421 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,058726 0,07670063 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,058726 0,0766571 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,06109833 0,07970854 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,06109833 0,07966335 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,06109833 0,07961822 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,06109833 0,07957313 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,06109833 0,0795281 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,06109833 0,07948312 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,06109833 0,07943819 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 43 25 0,000 0,06109833 0,07939331 ! male gonad development GO:0008584 33 25 0,000 0,06109833 0,07934848 ! iron ion homeostasis GO:0055072 39 25 0,000 0,06109833 0,0793037 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,06109833 0,07925897 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,06109833 0,07921429 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,06109833 0,07916966 ! phospholipid transport GO:0015914 35 25 0,000 0,06109833 0,07912508 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,06109833 0,07908056 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,06109833 0,07903608 ! detection of light stimulus GO:0009583 30 25 0,000 0,06109833 0,07899165 ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,06109833 0,07894728 ! leukocyte proliferation GO:0070661 39 25 0,000 0,06109833 0,07890295 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,06109833 0,07885867 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,06346481 0,08186711 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,06346481 0,08182122 ! translational initiation GO:0006413 43 26 0,000 0,06346481 0,08177538 ! regulation of pH GO:0006885 36 26 0,000 0,06346481 0,0817296 ! circadian rhythm GO:0007623 42 26 0,000 0,06346481 0,08168386 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,06346481 0,08163818 ! post-embryonic development GO:0009791 42 26 0,000 0,06346481 0,08159254 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,06346481 0,08154696 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,06346481 0,08150143 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,06346481 0,08145595 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,06346481 0,08141052 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,06346481 0,08136514 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,06346481 0,08131981 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,06582546 0,08429764 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,06582546 0,08425073 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,06582546 0,08420387 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,06582546 0,08415706 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,06582546 0,08411031 ! catechol metabolic process GO:0009712 43 27 0,000 0,06582546 0,08406361 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,06582546 0,08401696 ! acute-phase response GO:0006953 42 27 0,000 0,06582546 0,08397036 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,06582546 0,08392381 ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,06582546 0,08387732 ! response to ionizing radiation GO:0010212 47 27 0,000 0,06582546 0,08383087 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,06582546 0,08378448 ! natural killer cell activation GO:0030101 35 27 0,000 0,06582546 0,08373814 ! lipid oxidation GO:0034440 38 27 0,000 0,06582546 0,08369185 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,06582546 0,08364561 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,06582546 0,08359943 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,06582546 0,08355329 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,06582546 0,0835072 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,06582546 0,08346117 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,0681803 0,08639928 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,0681803 0,0863517 ! phenol metabolic process GO:0018958 44 28 0,000 0,0681803 0,08630417 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,0681803 0,0862567 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,0681803 0,08620928 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,0681803 0,08616191 ! cell junction assembly GO:0034329 56 28 0,000 0,0681803 0,0861146 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,0681803 0,08606734 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,0681803 0,08602012 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,0681803 0,08597296 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,0681803 0,08592585 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,0681803 0,0858788 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,0681803 0,08583179 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,0681803 0,08578484 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,0681803 0,08573794 ! mesoderm formation GO:0001707 46 28 0,000 0,0681803 0,08569108 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,0681803 0,08564428 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,0681803 0,08559754 ! ensheathment of neurons GO:0007272 43 28 0,000 0,0681803 0,08555084 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,0681803 0,08550419 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,0681803 0,08545759 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,0681803 0,08541105 ! neural tube formation GO:0001841 41 28 0,000 0,0681803 0,08536455 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,0681803 0,08531811 ! placenta development GO:0001890 37 28 0,000 0,0681803 0,08527172 ! regulation of B cell activation GO:0050864 42 28 0,000 0,0681803 0,08522537 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,07052933 0,08811378 ! regulation of innate immune response GO:0045088 38 29 0,000 0,07052933 0,08806594 ! ovulation cycle process GO:0022602 41 29 0,000 0,07052933 0,08801816 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,07052933 0,08797043 ! protein targeting to membrane GO:0006612 53 29 0,000 0,07052933 0,08792275 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,07052933 0,08787512 ! mismatch repair GO:0006298 34 29 0,000 0,07052933 0,08782754 ! formation of primary germ layer GO:0001704 48 29 0,000 0,07052933 0,08778001 ! telencephalon development GO:0021537 52 29 0,000 0,07052933 0,08773254 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,07052933 0,08768512 ! eye morphogenesis GO:0048592 51 29 0,000 0,07052933 0,08763775 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,07052933 0,08759042 ! tissue homeostasis GO:0001894 42 29 0,000 0,07052933 0,08754316 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,07287258 0,09040288 ! collagen metabolic process GO:0032963 40 30 0,000 0,07287258 0,09035414 ! organic anion transport GO:0015711 51 30 0,000 0,07287258 0,09030546 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,07287258 0,09025683 ! spliceosome assembly GO:0000245 49 30 0,000 0,07287258 0,09020825 ! spindle organization GO:0007051 37 30 0,000 0,07287258 0,09015973 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,07287258 0,09011126 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,07287258 0,09006284 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,07287258 0,09001447 ! ceramide metabolic process GO:0006672 43 30 0,000 0,07287258 0,08996615 ! ovulation cycle GO:0042698 43 30 0,000 0,07287258 0,08991788 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,07287258 0,08986967 ! adult locomotory behavior GO:0008344 47 30 0,000 0,07287258 0,08982151 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,07287258 0,0897734 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,07287258 0,08972534 ! response to heat GO:0009408 41 30 0,000 0,07287258 0,08967733 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,07287258 0,08962938 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,07287258 0,08958147 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,07521006 0,09240552 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,07521006 0,09235618 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,07521006 0,0923069 ! odontogenesis GO:0042476 50 31 0,000 0,07521006 0,09225767 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,07521006 0,09220849 ! segmentation GO:0035282 41 31 0,000 0,07521006 0,09215937 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,07521006 0,09211029 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,07521006 0,09206127 ! metanephros development GO:0001656 58 31 0,000 0,07521006 0,0920123 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,07521006 0,09196339 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,07521006 0,09191452 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,07521006 0,09186571 ! cell fate specification GO:0001708 37 31 0,000 0,07521006 0,09181695 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,07521006 0,09176824 GO:0060326|cell chemotaxis, ! RNA modification GO:0009451 40 31 0,000 0,07521006 0,09171958 ! regulation of muscle development GO:0048634 48 32 0,000 0,07754177 0,09451302 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,07754177 0,09446296 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,07754177 0,09441296 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,07754177 0,094363 ! meiosis I GO:0007127 52 32 0,000 0,07754177 0,0943131 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,07754177 0,09426325 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,07754177 0,09421346 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,07754177 0,09416371 ! peripheral nervous system development GO:0007422 53 32 0,000 0,07754177 0,09411402 ! regulation of protein stability GO:0031647 48 32 0,000 0,07754177 0,09406438 ! cytokine production GO:0001816 44 32 0,000 0,07754177 0,0940148 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,07754177 0,09396526 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,07754177 0,09391578 ! vesicle localization GO:0051648 47 32 0,000 0,07754177 0,09386635 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,07986774 0,09663114 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,07986774 0,09658034 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,07986774 0,09652959 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,07986774 0,09647889 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,07986774 0,09642824 ! sister chromatid segregation GO:0000819 46 33 0,000 0,07986774 0,09637765 ! ear morphogenesis GO:0042471 42 33 0,000 0,07986774 0,09632711 ! cell junction organization GO:0034330 63 33 0,000 0,07986774 0,09627663 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,07986774 0,09622619 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,07986774 0,09617581 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,07986774 0,09612549 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,07986774 0,09607521 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,07986774 0,09602499 ! female gonad development GO:0008585 49 33 0,000 0,07986774 0,09597482 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,07986774 0,0959247 ! positive regulation of cell development GO:0010720 54 33 0,000 0,07986774 0,09587464 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,07986774 0,09582462 ! regulation of proteolysis GO:0030162 50 33 0,000 0,07986774 0,09577466 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,07986774 0,09572475 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,07986774 0,0956749 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,07986774 0,09562509 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,07986774 0,09557534 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,08218798 0,09830075 ! mRNA catabolic process GO:0006402 48 34 0,000 0,08218798 0,09824966 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,08218798 0,09819862 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,08218798 0,09814764 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,08218798 0,0980967 ! feeding behavior GO:0007631 45 34 0,000 0,08218798 0,09804582 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,08218798 0,097995 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,08218798 0,09794422 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,08218798 0,0978935 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,08218798 0,09784283 ! neuron migration GO:0001764 46 34 0,000 0,08218798 0,09779221 ! female gamete generation GO:0007292 43 34 0,000 0,08218798 0,09774165 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,08218798 0,09769114 ! polyol metabolic process GO:0019751 44 34 0,000 0,08218798 0,09764068 ! aerobic respiration GO:0009060 47 34 0,000 0,08218798 0,09759027 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,08218798 0,09753991 ! embryonic organ development GO:0048568 45 34 0,000 0,08218798 0,09748961 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,08218798 0,09743935 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,0845025 0,10013176 ! Notch signaling pathway GO:0007219 56 35 0,000 0,0845025 0,1000802 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,0845025 0,10002869 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,0845025 0,09997723 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,0845025 0,09992583 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,0845025 0,09987448 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,0845025 0,09982319 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,0845025 0,09977194 ! glycogen metabolic process GO:0005977 48 35 0,000 0,0845025 0,09972075 ! pigment metabolic process GO:0042440 61 35 0,000 0,0845025 0,09966961 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,0845025 0,09961852 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,08681131 0,10228792 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,08681131 0,10223554 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,08681131 0,10218322 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,08681131 0,10213095 ! negative regulation of binding GO:0051100 58 36 0,000 0,08681131 0,10207874 ! neural tube development GO:0021915 50 36 0,000 0,08681131 0,10202658 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,08681131 0,10197447 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,08681131 0,10192242 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,08681131 0,10187042 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,08681131 0,10181847 ! glucan metabolic process GO:0044042 49 36 0,000 0,08681131 0,10176657 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,08911444 0,10441325 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,08911444 0,10436008 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,08911444 0,10430697 ! learning GO:0007612 67 37 0,000 0,08911444 0,10425392 ! ion transmembrane transport GO:0034220 56 37 0,000 0,08911444 0,10420092 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,08911444 0,10414797 ! amino acid activation GO:0043038 52 37 0,000 0,08911444 0,10409507 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,08911444 0,10404223 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,09141188 0,10667039 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,09141188 0,10661629 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,09141188 0,10656225 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,09141188 0,10650827 ! phagocytosis GO:0006909 60 38 0,000 0,09141188 0,10645434 ! mesenchymal cell development GO:0014031 64 38 0,000 0,09141188 0,10640047 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,09141188 0,10634665 ! maintenance of location in cell GO:0051651 69 38 0,000 0,09141188 0,10629289 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,09370367 0,10890269 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,09370367 0,10884769 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,09370367 0,10879275 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,09370367 0,10873786 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,09370367 0,10868302 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,09370367 0,10862824 ! male sex differentiation GO:0046661 53 39 0,000 0,09370367 0,10857352 ! chromatin remodeling GO:0006338 68 39 0,000 0,09370367 0,10851885 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,09370367 0,10846423 ! JNK cascade GO:0007254 54 39 0,000 0,09370367 0,10840967 ! synapse organization GO:0050808 55 39 0,000 0,09370367 0,10835517 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,0959898 0,11094299 ! regulation of tube size GO:0035150 60 40 0,000 0,0959898 0,11088726 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,0959898 0,1108316 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,0959898 0,11077599 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,0959898 0,11072043 ! peptide metabolic process GO:0006518 56 40 0,000 0,0959898 0,11066493 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,0959898 0,11060949 ! inner ear development GO:0048839 57 40 0,000 0,0959898 0,1105541 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,0959898 0,11049877 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,0959898 0,11044349 ! B cell differentiation GO:0030183 62 40 0,000 0,0959898 0,11038827 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,0959898 0,1103331 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,0959898 0,11027799 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,0982703 0,11284158 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,0982703 0,11278527 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,0982703 0,11272902 ! glucose transport GO:0015758 52 41 0,000 0,0982703 0,11267282 ! striated muscle contraction GO:0006941 62 41 0,000 0,0982703 0,11261668 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,0982703 0,1125606 ! biopolymer methylation GO:0043414 62 41 0,000 0,0982703 0,11250457 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,0982703 0,1124486 ! mitochondrial transport GO:0006839 60 42 0,000 0,10054517 0,11499448 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,10054517 0,11493733 ! cellular component disassembly GO:0022411 64 42 0,000 0,10054517 0,11488023 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,10054517 0,11482319 ! hexose transport GO:0008645 54 42 0,000 0,10054517 0,1147662 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,10054517 0,11470928 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,10054517 0,1146524 ! excretion GO:0007588 63 42 0,000 0,10054517 0,11459559 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,10054517 0,11453883 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,10054517 0,11448213 ! positive regulation of binding GO:0051099 59 43 0,000 0,10281444 0,11700802 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,10281444 0,11695016 ! leukocyte migration GO:0050900 60 43 0,000 0,10281444 0,11689235 ! neuromuscular process GO:0050905 79 43 0,000 0,10281444 0,11683459 ! activation of caspase activity GO:0006919 65 43 0,000 0,10281444 0,1167769 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,10281444 0,11671926 ! tRNA processing GO:0008033 49 43 0,000 0,10281444 0,11666167 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,10281444 0,11660415 ! methylation GO:0032259 64 43 0,000 0,10281444 0,11654668 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,10507811 0,11905402 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,10507811 0,1189954 ! glycolysis GO:0006096 53 44 0,000 0,10507811 0,11893684 ! regulation of action potential GO:0001508 71 44 0,000 0,10507811 0,11887834 ! regulation of ion transport GO:0043269 57 44 0,000 0,10507811 0,11881989 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,10507811 0,1187615 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,10507811 0,11870317 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,10507811 0,1186449 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,10507811 0,11858668 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,10507811 0,11852852 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,10507811 0,11847042 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,10507811 0,11841238 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,10507811 0,11835439 ! RNA catabolic process GO:0006401 64 45 0,000 0,1073362 0,1208386 ! positive regulation of defense response GO:0031349 59 45 0,000 0,1073362 0,12077948 ! regulation of translational initiation GO:0006446 64 45 0,000 0,1073362 0,12072042 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,1073362 0,12066142 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,1073362 0,12060247 ! cell recognition GO:0008037 58 45 0,000 0,1073362 0,12054359 ! cell maturation GO:0048469 60 45 0,000 0,1073362 0,12048476 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,10958872 0,1229532 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,10958872 0,12289325 ! cell redox homeostasis GO:0045454 63 46 0,000 0,10958872 0,12283336 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,10958872 0,12277353 ! regulation of ossification GO:0030278 71 46 0,000 0,10958872 0,12271376 ! histone modification GO:0016570 68 46 0,000 0,10958872 0,12265404 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,11183569 0,12510802 ! viral infectious cycle GO:0019058 71 47 0,000 0,11183569 0,1250472 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,11183569 0,12498643 ! endocrine system development GO:0035270 83 47 0,000 0,11183569 0,12492573 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,11183569 0,12486509 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,11183569 0,1248045 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,11183569 0,12474398 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,11183569 0,12468351 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! chloride transport GO:0006821 67 48 0,000 0,11407711 0,12712081 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,11407711 0,12705925 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 0,000 0,11407711 0,12699775 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,11407711 0,12693631 ! gastrulation GO:0007369 73 48 0,000 0,11407711 0,12687493 ! heart morphogenesis GO:0003007 65 48 0,000 0,11407711 0,12681361 ! regulation of DNA replication GO:0006275 75 48 0,000 0,11407711 0,12675235 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,11407711 0,12669114 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,11407711 0,12663 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,11407711 0,12656891 ! nuclear export GO:0051168 69 48 0,000 0,11407711 0,12650789 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,11407711 0,12644692 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,11631301 0,12886316 ! sensory perception of smell GO:0007608 61 49 0,000 0,11631301 0,12880112 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,11631301 0,12873913 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,11631301 0,12867721 ! RNA elongation GO:0006354 62 49 0,000 0,11631301 0,12861535 ! germ cell development GO:0007281 68 49 0,000 0,11631301 0,12855354 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,11631301 0,1284918 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,11631301 0,12843011 ! cartilage development GO:0051216 70 49 0,000 0,11631301 0,12836848 ! maintenance of location GO:0051235 84 49 0,000 0,11631301 0,12830692 ! ear development GO:0043583 72 50 0,000 0,11854339 0,1307046 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,11854339 0,13064197 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,11854339 0,1305794 ! positive regulation of growth GO:0045927 67 50 0,000 0,11854339 0,1305169 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,11854339 0,13045445 ! proton transport GO:0015992 75 50 0,000 0,11854339 0,13039206 ! positive regulation of secretion GO:0051047 71 51 0,000 0,12076827 0,13277582 ! hydrogen transport GO:0006818 77 51 0,000 0,12076827 0,13271238 ! muscle fiber development GO:0048747 74 51 0,000 0,12076827 0,132649 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,12076827 0,13258569 ! adult behavior GO:0030534 80 51 0,000 0,12076827 0,13252243 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,12076827 0,13245924 ! transition metal ion transport GO:0000041 74 52 0,000 0,12298766 0,13482918 ! aging GO:0007568 79 52 0,000 0,12298766 0,13476494 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,12298766 0,13470077 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,12298766 0,13463666 ! establishment of organelle localization GO:0051656 85 52 0,000 0,12298766 0,1345726 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,12520157 0,13692992 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,12520157 0,13686484 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,12520157 0,13679982 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,12520157 0,13673486 ! single fertilization GO:0007338 59 53 0,000 0,12520157 0,13666997 ! amino acid transport GO:0006865 84 54 0,000 0,12741003 0,13901474 ! glucose catabolic process GO:0006007 66 54 0,000 0,12741003 0,13894882 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,12741003 0,13888297 ! DNA catabolic process GO:0006308 67 54 0,000 0,12741003 0,13881718 ! detection of external stimulus GO:0009581 66 54 0,000 0,12741003 0,13875145 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,12741003 0,13868578 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,12741003 0,13862018 ! exocytosis GO:0006887 74 55 0,000 0,12961303 0,14095034 ! mesoderm development GO:0007498 76 55 0,000 0,12961303 0,14088373 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,12961303 0,14081718 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,12961303 0,14075069 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,1318106 0,14306955 ! carbohydrate transport GO:0008643 74 57 0,000 0,13400275 0,14538034 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,13400275 0,14531179 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,13400275 0,14524332 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,13400275 0,1451749 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,13400275 0,14510655 ! camera-type eye development GO:0043010 88 57 0,000 0,13400275 0,14503827 ! secondary metabolic process GO:0019748 84 57 0,000 0,13400275 0,14497004 ! developmental maturation GO:0021700 75 57 0,000 0,13400275 0,14490189 ! gonad development GO:0008406 79 57 0,000 0,13400275 0,14483379 ! viral reproductive process GO:0022415 87 58 0,000 0,13618948 0,14712814 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,13618948 0,14705906 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,13618948 0,14699006 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,13618948 0,14692111 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,13837082 0,14920436 ! lung development GO:0030324 94 59 0,000 0,13837082 0,14913444 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,13837082 0,14906459 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,13837082 0,1489948 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,14054678 0,151267 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,14054678 0,15119625 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,14054678 0,15112557 ! regulation of heart contraction GO:0008016 91 60 0,000 0,14054678 0,15105495 ! fertilization GO:0009566 68 60 0,000 0,14054678 0,15098439 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,14054678 0,15091391 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,14271736 0,15317309 ! meiosis GO:0007126 96 61 0,000 0,14271736 0,15310165 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,14271736 0,15303027 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,14271736 0,15295896 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,14271736 0,15288772 ! extracellular matrix organization GO:0030198 103 61 0,000 0,14271736 0,15281654 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,14271736 0,15274543 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,14271736 0,15267439 ! amine catabolic process GO:0009310 90 62 0,000 0,14488259 0,15491862 ! neurotransmitter transport GO:0006836 81 62 0,000 0,14488259 0,15484664 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,14488259 0,15477471 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,14488259 0,15470286 ! respiratory tube development GO:0030323 99 62 0,000 0,14488259 0,15463107 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,14488259 0,15455935 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,14488259 0,1544877 ! meiotic cell cycle GO:0051321 97 62 0,000 0,14488259 0,15441611 ! organelle localization GO:0051640 96 62 0,000 0,14488259 0,15434459 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,14704247 0,15657301 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,14704247 0,15650055 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,14704247 0,15642816 ! viral reproduction GO:0016032 92 63 0,000 0,14704247 0,15635584 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,14919703 0,15857355 ! negative regulation of cell size GO:0045792 108 64 0,000 0,14919703 0,1585003 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,14919703 0,15842713 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,14919703 0,15835402 ! hexose catabolic process GO:0019320 82 64 0,000 0,14919703 0,15828098 ! respiratory system development GO:0060541 100 64 0,000 0,14919703 0,158208 ! adaptive immune response GO:0002250 94 64 0,000 0,14919703 0,1581351 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,15134626 0,1603392 ! B cell activation GO:0042113 104 65 0,000 0,15134626 0,16026537 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,15134626 0,16019162 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,15134626 0,16011794 ! defense response to bacterium GO:0042742 73 65 0,000 0,15134626 0,16004432 ! activation of immune response GO:0002253 83 65 0,000 0,15134626 0,15997077 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,15349018 0,16216234 ! antigen processing and presentation GO:0019882 96 66 0,000 0,15349018 0,16208789 ! axon guidance GO:0007411 99 66 0,000 0,15349018 0,1620135 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,15562882 0,16419554 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,15562882 0,16412026 ! acute inflammatory response GO:0002526 92 68 0,000 0,15776217 0,16629376 ! learning or memory GO:0007611 123 68 0,000 0,15776217 0,16621759 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,15776217 0,16614148 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,15776217 0,16606544 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,15776217 0,16598947 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,15776217 0,16591358 ! rhythmic process GO:0048511 105 68 0,000 0,15776217 0,16583775 ! inorganic anion transport GO:0015698 93 68 0,000 0,15776217 0,16576199 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,15989025 0,16792127 ! response to drug GO:0042493 108 69 0,000 0,15989025 0,16784463 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,15989025 0,16776806 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,16201308 0,16991796 ! humoral immune response GO:0006959 86 70 0,000 0,16201308 0,16984052 ! amine transport GO:0015837 101 70 0,000 0,16201308 0,16976314 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,16201308 0,16968583 ! regulation of catabolic process GO:0009894 106 70 0,000 0,16201308 0,1696086 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,16413067 0,17174729 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,16413067 0,17166919 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,16413067 0,17159116 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,16413067 0,1715132 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,16413067 0,17143531 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,16624303 0,17356285 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,16624303 0,1734841 ! regulation of blood pressure GO:0008217 107 73 0,000 0,16835017 0,17560335 ! mitochondrion organization GO:0007005 104 73 0,000 0,16835017 0,17552375 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,16835017 0,17544422 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,16835017 0,17536476 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,1704521 0,1774739 ! digestion GO:0007586 97 74 0,000 0,1704521 0,17739359 ! protein import into nucleus GO:0006606 118 74 0,000 0,1704521 0,17731336 ! blood coagulation GO:0007596 116 75 0,000 0,17254885 0,17941336 GO:0050817|coagulation, ! negative regulation of growth GO:0045926 123 75 0,000 0,17254885 0,17933229 ! response to nutrient GO:0007584 104 75 0,000 0,17254885 0,17925129 ! regulation of ligase activity GO:0051340 114 75 0,000 0,17254885 0,17917036 ! nuclear import GO:0051170 121 75 0,000 0,17254885 0,17908951 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,17254885 0,17900873 ! tRNA metabolic process GO:0006399 95 76 0,000 0,17464041 0,18109691 ! response to unfolded protein GO:0006986 99 76 0,000 0,17464041 0,1810153 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,17672681 0,18309534 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,17672681 0,1830129 ! regulation of DNA binding GO:0051101 119 77 0,000 0,17672681 0,18293054 ! sex differentiation GO:0007548 105 77 0,000 0,17672681 0,18284825 ! protein ubiquitination GO:0016567 125 77 0,000 0,17672681 0,18276603 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,17672681 0,18268389 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,17672681 0,18260182 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,17672681 0,18251983 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,17880805 0,18458641 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,17880805 0,1845036 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,17880805 0,18442086 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,18088415 0,1864785 ! cellular respiration GO:0045333 107 79 0,000 0,18088415 0,18639496 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,18088415 0,18631148 ! regulation of lyase activity GO:0051339 133 79 0,000 0,18088415 0,18622809 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,18088415 0,18614476 ! chromatin assembly GO:0031497 102 80 0,000 0,18295512 0,18819176 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,18295512 0,18810763 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,18295512 0,18802358 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,18295512 0,18793961 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,18295512 0,1878557 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,18502097 0,18989212 ! hemostasis GO:0007599 125 81 0,000 0,18502097 0,18980742 ! mRNA transport GO:0051028 121 81 0,000 0,18502097 0,1897228 ! response to protein stimulus GO:0051789 111 81 0,000 0,18502097 0,18963825 ! regulation of neurological system process GO:0031644 122 81 0,000 0,18502097 0,18955378 ! vitamin metabolic process GO:0006766 103 81 0,000 0,18502097 0,18946938 ! detection of stimulus GO:0051606 108 82 0,000 0,18708172 0,19149442 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,18913738 0,19351244 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of defense response GO:0031347 117 84 0,000 0,19118795 0,19552347 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,19118795 0,19543657 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,19118795 0,19534975 ! sterol metabolic process GO:0016125 120 84 0,000 0,19118795 0,19526301 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,19323346 0,19726452 ! rRNA metabolic process GO:0016072 107 85 0,000 0,19323346 0,197177 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,19323346 0,19708956 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,19323346 0,1970022 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,19527391 0,19899424 ! cell cycle arrest GO:0007050 150 86 0,000 0,19527391 0,19890611 ! nucleosome organization GO:0034728 114 87 0,000 0,19730932 0,20089041 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,19730932 0,20080152 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,19730932 0,20071271 ! female pregnancy GO:0007565 130 87 0,000 0,19730932 0,20062397 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,19730932 0,20053532 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,19933969 0,20250941 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,19933969 0,20242 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,19933969 0,20233067 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,19933969 0,20224142 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,19933969 0,20215225 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,20136505 0,20411618 ! reproductive developmental process GO:0003006 127 89 0,000 0,20136505 0,20402626 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,20136505 0,20393642 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,20136505 0,20384666 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,2033854 0,20580133 ! hormone metabolic process GO:0042445 121 90 0,000 0,2033854 0,20571083 ! RNA localization GO:0006403 135 91 0,000 0,20540075 0,2076579 ! ATP metabolic process GO:0046034 137 91 0,000 0,20540075 0,20756667 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,20741112 0,20950619 ! positive regulation of immune response GO:0050778 121 92 0,000 0,20741112 0,20941422 ! DNA recombination GO:0006310 146 92 0,000 0,20741112 0,20932233 ! sulfur metabolic process GO:0006790 118 92 0,000 0,20741112 0,20923052 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,20941653 0,2111609 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,20941653 0,21106836 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,20941653 0,21097591 ! electron transport chain GO:0022900 123 94 0,000 0,21141697 0,212898 ! response to oxidative stress GO:0006979 141 94 0,000 0,21141697 0,21280482 ! regulation of binding GO:0051098 151 95 0,000 0,21341246 0,21471945 ! carboxylic acid transport GO:0046942 147 95 0,000 0,21341246 0,21462556 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,21540302 0,21653276 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,21540302 0,21643816 ! protein maturation GO:0051604 129 96 0,000 0,21540302 0,21634364 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,21738866 0,21824265 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,21738866 0,21814743 ! extracellular structure organization GO:0043062 156 99 0,000 0,22134521 0,22202092 ! protein import GO:0017038 156 99 0,000 0,22134521 0,22192414 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,22134521 0,22182744 ! regulation of translation GO:0006417 151 100 0,000 0,22331614 0,2237052 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,22331614 0,22360781 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,22331614 0,2235105 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,22331614 0,22341328 ! protein localization in organelle GO:0033365 161 100 0,000 0,22331614 0,22331614