pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/753-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 6,651E-07 1,53E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,13E-05 0,01299862 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,328E-05 0,01017839 ! ureteric bud development GO:0001657 32 22 2,000 1,788E-05 0,01027875 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 2,342E-05 0,0107722 ! metanephros development GO:0001656 58 31 2,000 5,142E-05 0,01971012 ! positive regulation of vasoconstriction GO:0045907 9 5 1,000 5,343E-05 0,01755404 ! enteric nervous system development GO:0048484 8 5 1,000 5,343E-05 0,01535979 ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 5,343E-05 0,01365314 ! protein homooligomerization GO:0051260 52 35 2,000 7,438E-05 0,01710767 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 8,002E-05 0,01673122 ! gas homeostasis GO:0033483 11 6 1,000 8,002E-05 0,01533695 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 8,002E-05 0,01415719 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 8,002E-05 0,01314596 ! mesenchymal cell development GO:0014031 64 38 2,000 9,54E-05 0,01462867 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 1,032E-04 0,01483308 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,119E-04 0,01513399 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 1,119E-04 0,01429321 ! vesicle fusion GO:0006906 15 7 1,000 1,119E-04 0,01354093 ! mast cell activation GO:0045576 9 7 1,000 1,119E-04 0,01286389 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 1,000 1,119E-04 0,01225132 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 1,384E-04 0,01447279 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,489E-04 0,01489248 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,489E-04 0,01427196 ! S phase GO:0051320 8 8 1,000 1,489E-04 0,01370109 GO:0000084|S phase of mitotic cell cycle, ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 1,912E-04 0,01691298 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,912E-04 0,01628658 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 1,912E-04 0,01570491 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 1,000 1,912E-04 0,01516336 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 1,912E-04 0,01465792 ! localization within membrane GO:0051668 15 9 1,000 1,912E-04 0,01418508 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,386E-04 0,01715172 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 2,386E-04 0,01663197 ! kidney development GO:0001822 90 53 2,000 2,585E-04 0,01748949 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 2,912E-04 0,0191379 ! autonomic nervous system development GO:0048483 23 12 1,000 3,49E-04 0,02229438 ! gland morphogenesis GO:0022612 23 12 1,000 3,49E-04 0,02169183 ! cell-matrix adhesion GO:0007160 114 61 2,000 3,921E-04 0,02373045 ! urogenital system development GO:0001655 101 61 2,000 3,921E-04 0,02312198 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 4,118E-04 0,02367789 ! lipid localization GO:0010876 24 13 1,000 4,118E-04 0,02310038 GO:0019915|lipid storage, ! organelle fusion GO:0048284 28 13 1,000 4,118E-04 0,02255037 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,118E-04 0,02202594 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 4,118E-04 0,02152535 ! protein oligomerization GO:0051259 100 65 2,000 4,728E-04 0,02416318 ! neuron maturation GO:0042551 21 14 1,000 4,797E-04 0,02398537 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,797E-04 0,02347505 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 4,797E-04 0,02298598 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 4,797E-04 0,02251688 GO:0060675|ureteric bud morphogenesis, ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 4,797E-04 0,02206654 ! cell-substrate adhesion GO:0031589 121 66 2,000 4,945E-04 0,02229944 ! lipid phosphorylation GO:0046834 23 15 1,000 5,527E-04 0,02444576 ! myoblast differentiation GO:0045445 27 15 1,000 5,527E-04 0,02398452 ! regulation of vasodilation GO:0042312 24 15 1,000 5,527E-04 0,02354036 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 5,527E-04 0,02311236 ! protein secretion GO:0009306 27 16 1,000 6,307E-04 0,02590393 ! neural crest cell migration GO:0001755 24 16 1,000 6,307E-04 0,02544947 ! regulation of peptidase activity GO:0052547 106 72 2,000 6,382E-04 0,02530775 ! tube morphogenesis GO:0035239 118 73 2,000 6,645E-04 0,02590293 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 7,137E-04 0,02735992 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 7,137E-04 0,0269114 ! inactivation of MAPK activity GO:0000188 27 17 1,000 7,137E-04 0,02647734 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 7,137E-04 0,02605707 ! pancreas development GO:0031016 26 18 1,000 8,018E-04 0,02881334 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 8,018E-04 0,02837006 ! gut development GO:0048565 26 18 1,000 8,018E-04 0,02794021 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 8,948E-04 0,03071556 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 8,948E-04 0,03026386 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 8,948E-04 0,02982526 ! regulation of ARF GTPase activity GO:0032312 31 20 1,000 9,927E-04 0,03261729 ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 9,927E-04 0,03215789 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 1,071E-03 0,03419669 ! vesicle docking GO:0048278 27 21 1,000 1,096E-03 0,03451787 ! regulation of insulin secretion GO:0050796 26 21 1,000 1,096E-03 0,03405141 ! regulation of vasoconstriction GO:0019229 31 21 1,000 1,096E-03 0,03359739 ! skeletal muscle tissue development GO:0007519 123 87 2,000 1,107E-03 0,03349948 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 1,107E-03 0,03306442 ! interphase GO:0051325 159 88 2,000 1,144E-03 0,03373774 ! vasculogenesis GO:0001570 33 22 1,000 1,203E-03 0,03503384 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 1,203E-03 0,03459592 ! membrane depolarization GO:0051899 35 22 1,000 1,203E-03 0,03416881 ! regulation of blood coagulation GO:0030193 34 22 1,000 1,203E-03 0,03375211 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 1,316E-03 0,03646705 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 1,316E-03 0,03603292 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 1,316E-03 0,03560901 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 1,433E-03 0,03833755 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 1,433E-03 0,03789689 ! fat cell differentiation GO:0045444 37 24 1,000 1,433E-03 0,03746624 ! neural crest cell development GO:0014032 39 24 1,000 1,433E-03 0,03704528 GO:0014033|neural crest cell differentiation, ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 1,433E-03 0,03663366 ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 1,556E-03 0,03932323 ! regulation of peptide secretion GO:0002791 34 25 1,000 1,556E-03 0,03889581 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 1,556E-03 0,03847757 ! homophilic cell adhesion GO:0007156 149 100 2,000 1,653E-03 0,04045664 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 1,683E-03 0,04074598 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 1,683E-03 0,04032155 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 1,683E-03 0,03990586 ! regulation of coagulation GO:0050818 39 26 1,000 1,683E-03 0,03949866 ! membrane docking GO:0022406 39 27 1,000 1,815E-03 0,04216506 ! inner ear morphogenesis GO:0042472 35 27 1,000 1,815E-03 0,04174341 ! cholesterol homeostasis GO:0042632 46 28 1,000 1,952E-03 0,04444339 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 1,000 1,952E-03 0,04400767 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 1,952E-03 0,04358041 ! myeloid leukocyte activation GO:0002274 39 28 1,000 1,952E-03 0,04316136 ! mismatch repair GO:0006298 34 29 1,000 2,093E-03 0,04584895 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 2,093E-03 0,04541641 ! cholesterol transport GO:0030301 46 30 1,000 2,239E-03 0,04813425 GO:0015918|sterol transport, ! embryonic epithelial tube formation GO:0001838 44 30 1,000 2,239E-03 0,04768856 ! regulation of microtubule-based process GO:0032886 58 30 1,000 2,239E-03 0,04725105 ! mammary gland development GO:0030879 57 31 1,000 2,39E-03 0,04997642 ! regulation of ARF protein signal transduction GO:0032012 51 32 1,000 2,546E-03 0,05274968 ! neutral lipid metabolic process GO:0006638 41 32 1,000 2,546E-03 0,0522787 GO:0006639|acylglycerol metabolic process, ! calcium-mediated signaling GO:0019722 50 32 1,000 2,546E-03 0,05181606 ! cytokine production GO:0001816 44 32 1,000 2,546E-03 0,05136153 ! carbohydrate homeostasis GO:0033500 39 33 1,000 2,706E-03 0,05411948 GO:0042593|glucose homeostasis, ! androgen receptor signaling pathway GO:0030521 54 33 1,000 2,706E-03 0,05365293 ! ear morphogenesis GO:0042471 42 33 1,000 2,706E-03 0,05319436 ! lipid homeostasis GO:0055088 55 33 1,000 2,706E-03 0,05274356 ! establishment or maintenance of cell polarity GO:0007163 61 34 1,000 2,871E-03 0,05548682 ! glycerol ether metabolic process GO:0006662 44 34 1,000 2,871E-03 0,05502443 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 2,871E-03 0,05456969 ! Notch signaling pathway GO:0007219 56 35 1,000 3,04E-03 0,05731755 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 3,04E-03 0,05685156 ! regulation of hormone secretion GO:0046883 48 36 1,000 3,214E-03 0,05962193 ! organic ether metabolic process GO:0018904 46 36 1,000 3,214E-03 0,05914495 ! tissue remodeling GO:0048771 62 36 1,000 3,214E-03 0,05867555 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 3,764E-03 0,06816667 ! induction of apoptosis by intracellular signals GO:0008629 67 40 1,000 3,956E-03 0,07108848 ! inner ear development GO:0048839 57 40 1,000 3,956E-03 0,07053741 ! positive regulation of protein transport GO:0051222 55 40 1,000 3,956E-03 0,06999481 ! epithelial cell differentiation GO:0030855 55 41 1,000 4,153E-03 0,07291456 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 4,354E-03 0,07586791 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 4,354E-03 0,07529748 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 4,354E-03 0,07473556 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 4,56E-03 0,07768554 ! vesicle organization GO:0016050 79 43 1,000 4,56E-03 0,07711433 ! response to insulin stimulus GO:0032868 63 43 1,000 4,56E-03 0,07655145 ! positive regulation of cell cycle GO:0045787 77 45 1,000 4,984E-03 0,08307249 ! cell maturation GO:0048469 60 45 1,000 4,984E-03 0,08247484 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 4,984E-03 0,08188574 ! regulation of ossification GO:0030278 71 46 1,000 5,203E-03 0,08487503 ! response to UV GO:0009411 75 46 1,000 5,203E-03 0,08427732 ! regulation of protein polymerization GO:0032271 71 47 1,000 5,426E-03 0,08727825 ! regulation of muscle contraction GO:0006937 69 48 1,000 5,654E-03 0,09030686 ! regulation of intracellular transport GO:0032386 78 49 1,000 5,886E-03 0,09336225 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 5,886E-03 0,09272279 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 5,886E-03 0,09209202 ! ear development GO:0043583 72 50 1,000 6,122E-03 0,09514026 ! skeletal muscle fiber development GO:0048741 73 50 1,000 6,122E-03 0,09450174 ! membrane fusion GO:0006944 80 50 1,000 6,122E-03 0,09387173 ! lipid modification GO:0030258 73 50 1,000 6,122E-03 0,09325006 ! positive regulation of secretion GO:0051047 71 51 1,000 6,363E-03 0,09627524 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 6,363E-03 0,09564599 ! activation of phospholipase C activity GO:0007202 87 51 1,000 6,363E-03 0,09502492 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 6,363E-03 0,09441185 ! positive regulation of cell migration GO:0030335 92 51 1,000 6,363E-03 0,09380665 ! positive regulation of organelle organization GO:0010638 82 51 1,000 6,363E-03 0,09320915 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 6,607E-03 0,09618174 ! regulation of bone remodeling GO:0046850 90 53 1,000 6,856E-03 0,09917827 ! regulation of protein complex assembly GO:0043254 81 54 1,000 7,109E-03 0,10219801 ! regulation of phospholipase activity GO:0010517 90 54 1,000 7,109E-03 0,10156324 ! regulation of tissue remodeling GO:0034103 91 54 1,000 7,109E-03 0,1009363 ! positive regulation of lipase activity GO:0060193 90 54 1,000 7,109E-03 0,10031706 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 7,628E-03 0,10698346 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 7,628E-03 0,10633507 ! positive regulation of cell motion GO:0051272 99 56 1,000 7,628E-03 0,1056945 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 7,894E-03 0,10872134 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 7,894E-03 0,10807419 ! developmental maturation GO:0021700 75 57 1,000 7,894E-03 0,1074347 ! negative regulation of kinase activity GO:0033673 100 58 1,000 8,164E-03 0,1104539 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 8,164E-03 0,10980797 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 8,716E-03 0,11655199 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 8,716E-03 0,11587828 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of transferase activity GO:0051348 105 61 1,000 8,998E-03 0,11894213 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 9,575E-03 0,12583933 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 9,575E-03 0,12512434 ! regulation of lipase activity GO:0060191 109 63 1,000 9,575E-03 0,12441742 ! appendage morphogenesis GO:0035107 93 64 1,000 9,869E-03 0,1275211 GO:0035108|limb morphogenesis, ! regulation of caspase activity GO:0043281 97 65 1,000 0,01016732 0,13064152 ! appendage development GO:0048736 94 65 1,000 0,01016732 0,12991573 GO:0060173|limb development, ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,01016732 0,12919797 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,01077583 0,13617813 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,01108602 0,13933247 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,0116728 0,14591003 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,0116728 0,14512133 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,0116728 0,1443411 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,0116728 0,14356923 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,0116728 0,14280556 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,0116728 0,14204997 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,0116728 0,14130234 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,0116728 0,14056254 ! sleep GO:0030431 11 5 0,000 0,0116728 0,13983044 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,0116728 0,13910593 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,0116728 0,13838889 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,0116728 0,13767921 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,0116728 0,13697676 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,0116728 0,13628145 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,0116728 0,13559316 ! tongue development GO:0043586 6 5 0,000 0,0116728 0,13491179 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,0116728 0,13423723 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,0116728 0,13356938 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,0116728 0,13290814 ! cobalt ion transport GO:0006824 9 5 0,000 0,0116728 0,13225342 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,0116728 0,13160512 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,0116728 0,13096315 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,0116728 0,1303274 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,0116728 0,1296978 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,0116728 0,12907426 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,0116728 0,12845668 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,0116728 0,12784498 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,0116728 0,12723908 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,0116728 0,12663889 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,0116728 0,12604434 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,0116728 0,12545535 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,0116728 0,12487184 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,0116728 0,12429373 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,0116728 0,12372095 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,0116728 0,12315342 ! malate metabolic process GO:0006108 7 5 0,000 0,0116728 0,12259107 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,0116728 0,12203384 ! behavioral response to pain GO:0048266 7 5 0,000 0,0116728 0,12148165 ! clathrin coat assembly GO:0048268 11 5 0,000 0,0116728 0,12093444 ! phototransduction, visible light GO:0007603 6 5 0,000 0,0116728 0,12039213 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,0116728 0,11985467 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,0116728 0,11932198 ! mating behavior GO:0007617 6 5 0,000 0,0116728 0,11879401 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,0116728 0,11827068 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,0116728 0,11775195 ! rhythmic behavior GO:0007622 12 5 0,000 0,0116728 0,11723775 ! copulation GO:0007620 7 5 0,000 0,0116728 0,11672802 ! glial cell fate commitment GO:0021781 12 5 0,000 0,0116728 0,11622271 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,0116728 0,11572175 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,0116728 0,11522509 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,0116728 0,11473267 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,0116728 0,11424445 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,0116728 0,11376036 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,0116728 0,11328036 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,0116728 0,11280439 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,0116728 0,11233241 ! response to protozoan GO:0001562 9 5 0,000 0,0116728 0,11186436 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,0116728 0,11140019 ! lymph vessel development GO:0001945 7 5 0,000 0,0116728 0,11093986 ! endochondral ossification GO:0001958 12 5 0,000 0,0116728 0,11048331 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,0116728 0,11003051 ! parathyroid gland development GO:0060017 8 5 0,000 0,0116728 0,10958141 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,0116728 0,10913596 ! anagen GO:0042640 6 5 0,000 0,0116728 0,10869411 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,0116728 0,10825583 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,0116728 0,10782107 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,0116728 0,10738978 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,0116728 0,10696193 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,0116728 0,10653748 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,0116728 0,10611638 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,0116728 0,1056986 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,0116728 0,1052841 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,0116728 0,10487283 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,0116728 0,10446477 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,0116728 0,10405987 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,0116728 0,10365809 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,0116728 0,1032594 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,0116728 0,10286377 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,0116728 0,10247117 ! ovulation GO:0030728 6 5 0,000 0,0116728 0,10208154 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,0116728 0,10169487 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,0116728 0,10131111 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,0116728 0,10093025 ! response to pH GO:0009268 9 5 0,000 0,0116728 0,10055223 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,0116728 0,10017703 ! proline biosynthetic process GO:0006561 6 5 0,000 0,0116728 0,09980463 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,0116728 0,09943498 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,0116728 0,09906806 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,0116728 0,09870384 ! polyol catabolic process GO:0046174 7 5 0,000 0,0116728 0,09834229 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,0116728 0,09798338 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,0116728 0,09762707 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,0116728 0,09727335 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,0116728 0,09692218 ! nerve growth factor processing GO:0032455 7 5 0,000 0,0116728 0,09657354 ! urea metabolic process GO:0019627 6 5 0,000 0,0116728 0,0962274 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,0116728 0,09588373 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,0116728 0,09554251 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,0116728 0,09520371 ! neutrophil activation GO:0042119 5 5 0,000 0,0116728 0,0948673 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,0116728 0,09453326 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,0116728 0,09420156 ! response to food GO:0032094 5 5 0,000 0,0116728 0,09387219 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,0116728 0,09354511 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,0116728 0,0932203 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,0116728 0,09289773 ! forebrain neuron development GO:0021884 7 5 0,000 0,0116728 0,0925774 ! melanosome organization GO:0032438 7 5 0,000 0,0116728 0,09225926 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,0116728 0,09194331 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,0116728 0,09162951 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,0116728 0,09131784 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,0116728 0,09100829 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,0116728 0,09070083 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,0116728 0,09039544 ! nucleoside transport GO:0015858 6 5 0,000 0,0116728 0,0900921 ! nucleoside salvage GO:0043174 7 5 0,000 0,0116728 0,08979079 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,0116728 0,08949148 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,0116728 0,08919417 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,0116728 0,08889883 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,0116728 0,08860543 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,0116728 0,08831396 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,0116728 0,08802441 ! depyrimidination GO:0045008 8 5 0,000 0,0116728 0,08773675 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,0116728 0,08745096 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,0116728 0,08716703 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,0116728 0,08688494 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,0116728 0,08660466 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,0116728 0,08632619 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,0116728 0,0860495 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,0116728 0,08577459 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,0116728 0,08550142 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,0116728 0,08522998 ! monocyte differentiation GO:0030224 8 5 0,000 0,0116728 0,08496027 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,0116728 0,08469226 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,0116728 0,08442593 ! centrosome duplication GO:0051298 5 5 0,000 0,0116728 0,08416127 ! response to UV-C GO:0010225 6 5 0,000 0,0116728 0,08389827 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,0116728 0,0836369 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,0116728 0,08337716 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,0116728 0,08311903 ! regulation of dendrite development GO:0050773 12 5 0,000 0,0116728 0,08286249 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,0116728 0,08260752 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,0116728 0,08235413 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,0116728 0,08210228 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,0116728 0,08185197 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,0116728 0,08160318 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,0116728 0,08135589 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,0116728 0,08111011 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,0116728 0,0808658 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,0116728 0,08062296 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,0116728 0,08038157 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,0116728 0,08014163 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,0116728 0,07990311 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,0116728 0,07966601 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,0116728 0,07943031 ! neural tube patterning GO:0021532 6 5 0,000 0,0116728 0,079196 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,0116728 0,07896307 ! histone demethylation GO:0016577 9 5 0,000 0,0116728 0,07873151 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,0116728 0,0785013 ! regulation of sterol transport GO:0032371 7 5 0,000 0,0116728 0,07827244 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,0116728 0,0780449 ! establishment of planar polarity GO:0001736 6 5 0,000 0,0116728 0,07781868 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,0116728 0,07759377 ! muscle cell proliferation GO:0033002 8 5 0,000 0,0116728 0,07737016 ! transcription termination GO:0006353 8 5 0,000 0,0116728 0,07714783 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,0116728 0,07692678 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,0116728 0,07670699 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,0116728 0,07648845 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,0116728 0,07627115 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,0116728 0,07605509 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,0116728 0,07584024 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,0116728 0,07562661 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,0116728 0,07541417 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,0116728 0,07520293 ! apical protein localization GO:0045176 6 5 0,000 0,0116728 0,07499286 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,0116728 0,07478397 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,0116728 0,07457624 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,0116728 0,07436965 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,0116728 0,07416421 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,0116728 0,0739599 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,0116728 0,07375672 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,0116728 0,07355464 ! glial cell migration GO:0008347 10 5 0,000 0,0116728 0,07335368 ! determination of adult lifespan GO:0008340 8 5 0,000 0,0116728 0,0731538 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,0116728 0,07295501 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,0116728 0,0727573 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,0116728 0,07256066 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,0116728 0,07236508 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,0116728 0,07217055 ! neural plate development GO:0001840 6 5 0,000 0,0116728 0,07197706 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,0116728 0,07178461 ! regulation of sensory perception GO:0051931 6 5 0,000 0,0116728 0,07159319 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,0116728 0,07140278 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,0116728 0,07121338 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,0116728 0,07102499 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,0116728 0,07083759 ! sensory cilium assembly GO:0035058 6 5 0,000 0,0116728 0,07065117 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,0116728 0,07046574 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,0116728 0,07028127 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,0116728 0,07009777 ! spindle assembly GO:0051225 5 5 0,000 0,0116728 0,06991522 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,0116728 0,06973362 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,0116728 0,06955297 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,0116728 0,06937324 ! organ regeneration GO:0031100 7 5 0,000 0,0116728 0,06919445 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,0116728 0,06901657 ! carnitine metabolic process GO:0009437 5 5 0,000 0,0116728 0,0688396 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,0116728 0,06866354 GO:0055081|anion homeostasis, ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,01171814 0,06875439 ! muscle cell differentiation GO:0042692 104 71 1,000 0,01204004 0,07046334 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,01236581 0,07218618 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 1,000 0,01236581 0,07200343 ! response to oxygen levels GO:0070482 137 74 1,000 0,01302887 0,07567271 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,01302887 0,0754821 ! regulation of protein transport GO:0051223 114 76 1,000 0,01370717 0,07921228 GO:0070201|regulation of establishment of protein localization, ! tRNA transcription GO:0009304 11 6 0,000 0,01399136 0,08065194 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01399136 0,08045031 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01399136 0,08024969 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01399136 0,08005006 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01399136 0,07985143 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01399136 0,07965378 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01399136 0,0794571 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01399136 0,07926139 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01399136 0,07906665 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01399136 0,07887286 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01399136 0,07868001 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01399136 0,07848811 ! prostate gland development GO:0030850 9 6 0,000 0,01399136 0,07829714 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01399136 0,0781071 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01399136 0,07791798 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01399136 0,07772977 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01399136 0,07754247 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01399136 0,07735607 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01399136 0,07717057 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01399136 0,07698595 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01399136 0,07680221 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01399136 0,07661935 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01399136 0,07643735 ! neuron adhesion GO:0007158 9 6 0,000 0,01399136 0,07625622 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01399136 0,07607595 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01399136 0,07589652 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01399136 0,07571794 ! signal peptide processing GO:0006465 8 6 0,000 0,01399136 0,0755402 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01399136 0,07536329 ! mRNA stabilization GO:0048255 15 6 0,000 0,01399136 0,07518721 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01399136 0,07501195 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01399136 0,0748375 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01399136 0,07466386 ! opsonization GO:0008228 8 6 0,000 0,01399136 0,07449103 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01399136 0,074319 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01399136 0,07414775 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01399136 0,0739773 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01399136 0,07380763 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01399136 0,07363873 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01399136 0,07347061 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01399136 0,07330325 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01399136 0,07313665 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01399136 0,07297081 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01399136 0,07280571 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01399136 0,07264137 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01399136 0,07247776 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01399136 0,07231489 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01399136 0,07215275 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01399136 0,07199133 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01399136 0,07183064 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01399136 0,07167066 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01399136 0,07151139 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01399136 0,07135283 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01399136 0,07119497 ! thymic T cell selection GO:0045061 12 6 0,000 0,01399136 0,0710378 ! protein lipoylation GO:0009249 10 6 0,000 0,01399136 0,07088133 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01399136 0,07072555 ! pigment granule organization GO:0048753 11 6 0,000 0,01399136 0,07057045 ! drug transport GO:0015893 6 6 0,000 0,01399136 0,07041603 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01399136 0,07026228 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01399136 0,07010921 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01399136 0,06995679 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01399136 0,06980504 ! histidine metabolic process GO:0006547 6 6 0,000 0,01399136 0,06965395 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01399136 0,06950351 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01399136 0,06935372 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01399136 0,06920457 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01399136 0,06905606 ! adenohypophysis development GO:0021984 10 6 0,000 0,01399136 0,06890819 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01399136 0,06876095 ! hyperosmotic response GO:0006972 8 6 0,000 0,01399136 0,06861434 ! microtubule nucleation GO:0007020 10 6 0,000 0,01399136 0,06846835 ! ER overload response GO:0006983 7 6 0,000 0,01399136 0,06832298 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01399136 0,06817823 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01399136 0,06803409 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01399136 0,06789056 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01399136 0,06774763 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01399136 0,06760531 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01399136 0,06746358 ! response to dietary excess GO:0002021 7 6 0,000 0,01399136 0,06732244 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01399136 0,06718189 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01399136 0,06704193 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01399136 0,06690255 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01399136 0,06676375 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01399136 0,06662552 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01399136 0,06648786 ! neuron apoptosis GO:0051402 8 6 0,000 0,01399136 0,06635077 ! organic alcohol transport GO:0015850 9 6 0,000 0,01399136 0,06621425 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01399136 0,06607829 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01399136 0,06594288 ! male sex determination GO:0030238 9 6 0,000 0,01399136 0,06580803 ! carnitine transport GO:0015879 8 6 0,000 0,01399136 0,06567373 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01399136 0,06553997 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01399136 0,06540676 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01399136 0,06527409 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01399136 0,06514195 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01399136 0,06501035 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01399136 0,06487929 ! parturition GO:0007567 12 6 0,000 0,01399136 0,06474874 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01399136 0,06461873 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01399136 0,06448923 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01399136 0,06436025 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01399136 0,06423179 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01399136 0,06410384 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01399136 0,06397639 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01399136 0,06384946 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01399136 0,06372302 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01399136 0,06359709 ! macrophage differentiation GO:0030225 10 6 0,000 0,01399136 0,06347165 ! astrocyte development GO:0014002 14 6 0,000 0,01399136 0,0633467 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01399136 0,06322225 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01399136 0,06309829 ! interaction with symbiont GO:0051702 8 6 0,000 0,01399136 0,06297481 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01399136 0,06285181 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01399136 0,06272929 ! eating behavior GO:0042755 6 6 0,000 0,01399136 0,06260725 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01399136 0,06248568 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01399136 0,06236458 ! response to copper ion GO:0046688 9 6 0,000 0,01399136 0,06224396 ! DNA topological change GO:0006265 8 6 0,000 0,01399136 0,06212379 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01399136 0,0620041 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01399136 0,06188486 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01399136 0,06176608 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01399136 0,06164775 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01399136 0,06152988 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01399136 0,06141245 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01399136 0,06129548 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01399136 0,06117895 ! hair follicle maturation GO:0048820 7 6 0,000 0,01399136 0,06106286 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01399136 0,06094721 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01399136 0,060832 ! Schwann cell development GO:0014044 14 6 0,000 0,01399136 0,06071722 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01399136 0,06060287 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01399136 0,06048896 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01399136 0,06037547 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01399136 0,06026241 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01399136 0,06014977 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01399136 0,06003755 ! histone ubiquitination GO:0016574 7 6 0,000 0,01399136 0,05992575 ! regulation of meiosis GO:0040020 10 6 0,000 0,01399136 0,05981436 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01399136 0,05970339 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01399136 0,05959283 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01399136 0,05948267 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01399136 0,05937293 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01399136 0,05926358 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01399136 0,05915464 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01399136 0,0590461 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01399136 0,05893796 ! receptor internalization GO:0031623 9 6 0,000 0,01399136 0,05883021 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01399136 0,05872286 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01399136 0,05861589 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01399136 0,05850932 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01399136 0,05840313 ! protein deubiquitination GO:0016579 8 6 0,000 0,01399136 0,05829733 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01399136 0,05819191 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01399136 0,05808687 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01399136 0,05798221 ! axonal fasciculation GO:0007413 9 6 0,000 0,01399136 0,05787792 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01399136 0,05777401 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01399136 0,05767048 ! midbrain development GO:0030901 6 6 0,000 0,01399136 0,05756731 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01399136 0,05746451 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01399136 0,05736208 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01399136 0,05726001 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01399136 0,0571583 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01399136 0,05705696 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01399136 0,05695597 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01399136 0,05685535 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01399136 0,05675507 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01399136 0,05665515 ! adult feeding behavior GO:0008343 6 6 0,000 0,01399136 0,05655558 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01399136 0,05645636 ! blastocyst growth GO:0001832 15 6 0,000 0,01399136 0,05635749 ! pigment granule transport GO:0051904 12 6 0,000 0,01399136 0,05625896 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01399136 0,05616078 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01399136 0,05606294 ! catecholamine transport GO:0051937 7 6 0,000 0,01399136 0,05596544 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01399136 0,05586827 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01399136 0,05577145 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01399136 0,05567496 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01399136 0,0555788 ! protein prenylation GO:0018342 10 6 0,000 0,01399136 0,05548298 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01399136 0,05538748 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01399136 0,05529231 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01399136 0,05519747 ! gland development GO:0048732 148 77 1,000 0,01405199 0,05534173 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,0151089 0,0594025 ! ossification GO:0001503 134 82 1,000 0,01583203 0,06213936 GO:0060348|bone development, ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01630461 0,06388518 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01630461 0,06377653 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01630461 0,06366825 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01630461 0,06356034 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01630461 0,06345279 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01630461 0,06334561 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01630461 0,06323879 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01630461 0,06313232 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01630461 0,06302622 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01630461 0,06292047 ! reproductive behavior GO:0019098 12 7 0,000 0,01630461 0,06281508 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01630461 0,06271003 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,01630461 0,06260534 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01630461 0,062501 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,01630461 0,06239701 ! oligopeptide transport GO:0006857 11 7 0,000 0,01630461 0,06229336 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01630461 0,06219005 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01630461 0,06208709 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,01630461 0,06198446 ! pericardium development GO:0060039 8 7 0,000 0,01630461 0,06188218 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01630461 0,06178023 ! fibril organization GO:0043206 13 7 0,000 0,01630461 0,06167862 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01630461 0,06157734 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01630461 0,06147639 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01630461 0,06137578 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01630461 0,06127549 ! lipoprotein transport GO:0042953 9 7 0,000 0,01630461 0,06117553 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01630461 0,0610759 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01630461 0,06097659 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01630461 0,0608776 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01630461 0,06077893 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01630461 0,06068058 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01630461 0,06058255 ! chemosensory behavior GO:0007635 9 7 0,000 0,01630461 0,06048484 ! microtubule bundle formation GO:0001578 8 7 0,000 0,01630461 0,06038744 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,01630461 0,06029035 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01630461 0,06019358 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01630461 0,06009712 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01630461 0,06000096 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01630461 0,05990511 ! reflex GO:0060004 12 7 0,000 0,01630461 0,05980957 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01630461 0,05971433 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01630461 0,0596194 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01630461 0,05952476 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01630461 0,05943043 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01630461 0,05933639 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01630461 0,05924265 ! spinal cord patterning GO:0021511 7 7 0,000 0,01630461 0,05914921 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01630461 0,05905606 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,01630461 0,05896321 ! adrenal gland development GO:0030325 17 7 0,000 0,01630461 0,05887064 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01630461 0,05877837 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01630461 0,05868639 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01630461 0,05859469 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01630461 0,05850328 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01630461 0,05841215 ! endosome organization GO:0007032 10 7 0,000 0,01630461 0,05832131 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01630461 0,05823075 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,01630461 0,05814047 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01630461 0,05805046 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01630461 0,05796074 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01630461 0,0578713 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01630461 0,05778213 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01630461 0,05769323 ! galactose metabolic process GO:0006012 10 7 0,000 0,01630461 0,05760461 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01630461 0,05751626 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01630461 0,05742818 ! organ growth GO:0035265 11 7 0,000 0,01630461 0,05734037 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,01630461 0,05725282 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,01630461 0,05716555 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01630461 0,05707854 ! retinol metabolic process GO:0042572 9 7 0,000 0,01630461 0,05699179 ! behavioral fear response GO:0001662 13 7 0,000 0,01630461 0,05690531 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,01630461 0,05681909 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01630461 0,05673313 ! rRNA modification GO:0000154 12 7 0,000 0,01630461 0,05664743 ! protein heterooligomerization GO:0051291 10 7 0,000 0,01630461 0,05656199 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01630461 0,05647681 ! response to UV-B GO:0010224 11 7 0,000 0,01630461 0,05639188 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01630461 0,05630721 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,01630461 0,05622279 ! intermediate filament organization GO:0045109 11 7 0,000 0,01630461 0,05613862 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,01630461 0,05605471 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01630461 0,05597105 ! fibrinolysis GO:0042730 9 7 0,000 0,01630461 0,05588763 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01630461 0,05580446 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01630461 0,05572155 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01630461 0,05563887 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01630461 0,05555644 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01630461 0,05547426 ! response to tropane GO:0014073 13 7 0,000 0,01630461 0,05539232 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01630461 0,05531062 ! melanosome localization GO:0032400 10 7 0,000 0,01630461 0,05522916 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01630461 0,05514794 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01630461 0,05506696 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,01630461 0,05498622 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01630461 0,05490571 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01630461 0,05482544 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01630461 0,0547454 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01630461 0,0546656 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,01630461 0,05458603 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01630461 0,05450669 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01630461 0,05442758 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01630461 0,0543487 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01630461 0,05427004 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,01630461 0,05419162 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01630461 0,05411342 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01630461 0,05403545 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,01630461 0,0539577 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01630461 0,05388017 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01630461 0,05380287 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01630461 0,05372579 ! response to tumor cell GO:0002347 12 7 0,000 0,01630461 0,05364893 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01630461 0,05357229 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01630461 0,05349586 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01630461 0,05341966 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01630461 0,05334367 ! diuresis GO:0030146 12 7 0,000 0,01630461 0,0532679 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01630461 0,05319234 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01630461 0,053117 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01630461 0,05304187 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01630461 0,05296695 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01630461 0,05289224 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01630461 0,05281775 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01630461 0,05274346 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01630461 0,05266938 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01630461 0,05259551 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01630461 0,05252185 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01630461 0,05244839 ! lymph node development GO:0048535 9 7 0,000 0,01630461 0,05237514 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01630461 0,05230209 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01630461 0,05222925 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01630461 0,05215661 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,01630461 0,05208417 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,01630461 0,05201193 ! ATP catabolic process GO:0006200 10 7 0,000 0,01630461 0,05193989 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01630461 0,05186805 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01630461 0,05179641 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,01630461 0,05172497 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01630461 0,05165372 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01630461 0,05158267 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01630461 0,05151181 ! muscle adaptation GO:0043500 12 7 0,000 0,01630461 0,05144115 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01630461 0,05137069 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01630461 0,05130041 ! retina homeostasis GO:0001895 9 7 0,000 0,01630461 0,05123033 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01630461 0,05116044 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,01630461 0,05109074 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01630461 0,05102122 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,01630461 0,0509519 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01630461 0,05088277 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01630461 0,05081382 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01630461 0,05074506 ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,01694414 0,05266423 ! regulation of protein localization GO:0032880 132 85 1,000 0,01694414 0,05259316 ! regulation of membrane potential GO:0042391 128 85 1,000 0,01694414 0,05252228 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,01694414 0,05245159 ! cell cycle arrest GO:0007050 150 86 1,000 0,01732209 0,05354947 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,01861256 0,05746161 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,01861256 0,05738458 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,01861256 0,05730776 ! axon extension GO:0048675 11 8 0,000 0,01861256 0,05723114 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,01861256 0,05715473 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,01861256 0,05707853 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,01861256 0,05700253 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,01861256 0,05692672 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,01861256 0,05685112 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,01861256 0,05677572 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,01861256 0,05670053 ! phosphate transport GO:0006817 10 8 0,000 0,01861256 0,05662552 ! N-glycan processing GO:0006491 12 8 0,000 0,01861256 0,05655072 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,01861256 0,05647612 ! UTP metabolic process GO:0046051 8 8 0,000 0,01861256 0,05640171 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,01861256 0,0563275 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,01861256 0,05625348 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,01861256 0,05617965 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,01861256 0,05610602 ! succinate metabolic process GO:0006105 14 8 0,000 0,01861256 0,05603259 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,01861256 0,05595934 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,01861256 0,05588629 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,01861256 0,05581342 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,01861256 0,05574075 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,01861256 0,05566827 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,01861256 0,05559597 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,01861256 0,05552386 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01861256 0,05545194 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,01861256 0,0553802 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,01861256 0,05530865 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,01861256 0,05523729 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,01861256 0,0551661 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,01861256 0,0550951 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,01861256 0,05502429 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,01861256 0,05495365 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,01861256 0,0548832 ! astrocyte differentiation GO:0048708 16 8 0,000 0,01861256 0,05481293 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,01861256 0,05474283 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,01861256 0,05467292 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,01861256 0,05460318 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,01861256 0,05453363 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,01861256 0,05446424 ! melanin metabolic process GO:0006582 12 8 0,000 0,01861256 0,05439504 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,01861256 0,05432601 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,01861256 0,05425716 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,01861256 0,05418848 ! macrophage activation GO:0042116 12 8 0,000 0,01861256 0,05411997 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,01861256 0,05405164 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,01861256 0,05398348 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,01861256 0,05391549 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,01861256 0,05384767 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01861256 0,05378002 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,01861256 0,05371254 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,01861256 0,05364523 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,01861256 0,05357809 ! ruffle organization GO:0031529 11 8 0,000 0,01861256 0,05351112 ! osteoblast development GO:0002076 13 8 0,000 0,01861256 0,05344432 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,01861256 0,05337768 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,01861256 0,0533112 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,01861256 0,0532449 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,01861256 0,05317875 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,01861256 0,05311277 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,01861256 0,05304696 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,01861256 0,05298131 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,01861256 0,05291582 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,01861256 0,05285049 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,01861256 0,05278532 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,01861256 0,05272032 ! oligodendrocyte development GO:0014003 8 8 0,000 0,01861256 0,05265547 ! segment specification GO:0007379 10 8 0,000 0,01861256 0,05259078 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,01861256 0,05252625 ! cellular extravasation GO:0045123 11 8 0,000 0,01861256 0,05246188 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,01861256 0,05239767 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,01861256 0,05233361 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,01861256 0,05226971 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,01861256 0,05220597 ! snRNA metabolic process GO:0016073 10 8 0,000 0,01861256 0,05214238 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,01861256 0,05207895 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,01861256 0,05201567 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,01861256 0,05195254 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,01861256 0,05188957 ! nucleosome disassembly GO:0006337 12 8 0,000 0,01861256 0,05182675 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,01861256 0,05176408 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,01861256 0,05170157 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,01861256 0,0516392 ! icosanoid secretion GO:0032309 12 8 0,000 0,01861256 0,05157698 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,01861256 0,05151492 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,01861256 0,051453 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,01861256 0,05139123 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,01861256 0,05132961 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,01861256 0,05126814 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,01861256 0,05120681 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,01861256 0,05114563 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,01861256 0,0510846 ! sterol catabolic process GO:0016127 9 8 0,000 0,01861256 0,05102371 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,01861256 0,05096297 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,01861256 0,05090237 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,01861256 0,05084192 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,01861256 0,05078161 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,01861256 0,05072144 ! prophase GO:0051324 11 8 0,000 0,01861256 0,05066142 ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,01861256 0,05060153 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,01861256 0,05054179 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,01861256 0,05048219 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,01861256 0,05042273 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,01861256 0,05036341 ! hormone catabolic process GO:0042447 13 8 0,000 0,01861256 0,05030423 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,01861256 0,05024518 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,01861256 0,05018628 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,01861256 0,05012751 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,01861256 0,05006888 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,01861256 0,05001039 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,01861256 0,04995204 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,01861256 0,04989382 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,01861256 0,04983574 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,01861256 0,04977779 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,01861256 0,04971997 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,01861256 0,04966229 ! lamellipodium assembly GO:0030032 9 8 0,000 0,01861256 0,04960475 ! regulation of embryonic development GO:0045995 16 8 0,000 0,01861256 0,04954733 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,01861256 0,04949005 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,01861256 0,04943291 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,01861256 0,04937589 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,01966449 0,05210637 ! cell fate commitment GO:0045165 141 92 1,000 0,01966449 0,05204641 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,02006718 0,05305118 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,02006718 0,05299027 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,02091524 0,05516633 ! regulation of developmental growth GO:0048638 13 9 0,000 0,02091524 0,05510314 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,02091524 0,05504009 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02091524 0,05497719 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02091524 0,05491443 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02091524 0,05485181 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,02091524 0,05478934 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02091524 0,05472701 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02091524 0,05466482 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02091524 0,05460277 ! GTP metabolic process GO:0046039 9 9 0,000 0,02091524 0,05454086 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02091524 0,0544791 ! social behavior GO:0035176 14 9 0,000 0,02091524 0,05441747 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02091524 0,05435598 ! artery development GO:0060840 19 9 0,000 0,02091524 0,05429463 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02091524 0,05423342 ! regulation of glycolysis GO:0006110 15 9 0,000 0,02091524 0,05417234 ! response to pain GO:0048265 16 9 0,000 0,02091524 0,05411141 ! protein complex disassembly GO:0043241 17 9 0,000 0,02091524 0,05405061 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02091524 0,05398995 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02091524 0,05392942 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02091524 0,05386903 ! lung alveolus development GO:0048286 17 9 0,000 0,02091524 0,05380877 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02091524 0,05374865 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02091524 0,05368866 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02091524 0,05362881 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02091524 0,05356909 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02091524 0,0535095 ! protein targeting to ER GO:0045047 19 9 0,000 0,02091524 0,05345005 ! T cell selection GO:0045058 18 9 0,000 0,02091524 0,05339072 ! endoderm development GO:0007492 12 9 0,000 0,02091524 0,05333153 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02091524 0,05327247 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02091524 0,05321354 ! arginine catabolic process GO:0006527 10 9 0,000 0,02091524 0,05315474 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02091524 0,05309607 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02091524 0,05303753 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02091524 0,05297912 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02091524 0,05292084 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02091524 0,05286268 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02091524 0,05280466 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02091524 0,05274676 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02091524 0,05268898 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02091524 0,05263134 ! mannose metabolic process GO:0006013 9 9 0,000 0,02091524 0,05257382 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02091524 0,05251642 ! receptor clustering GO:0043113 15 9 0,000 0,02091524 0,05245915 ! epithelial cell development GO:0002064 10 9 0,000 0,02091524 0,05240201 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02091524 0,05234499 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02091524 0,05228809 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02091524 0,05223132 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02091524 0,05217467 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02091524 0,05211814 ! motor axon guidance GO:0008045 14 9 0,000 0,02091524 0,05206173 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02091524 0,05200545 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02091524 0,05194929 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02091524 0,05189325 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02091524 0,05183733 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02091524 0,05178153 ! DNA ligation GO:0006266 14 9 0,000 0,02091524 0,05172585 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02091524 0,05167029 ! response to amine stimulus GO:0014075 13 9 0,000 0,02091524 0,05161485 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02091524 0,05155953 ! erythrocyte development GO:0048821 11 9 0,000 0,02091524 0,05150433 ! renal water homeostasis GO:0003091 14 9 0,000 0,02091524 0,05144924 ! postreplication repair GO:0006301 11 9 0,000 0,02091524 0,05139427 ! mRNA cleavage GO:0006379 13 9 0,000 0,02091524 0,05133943 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02091524 0,05128469 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02091524 0,05123008 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02091524 0,05117558 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02091524 0,05112119 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02091524 0,05106692 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02091524 0,05101277 ! acid secretion GO:0046717 14 9 0,000 0,02091524 0,05095873 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02091524 0,05090481 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02091524 0,05085099 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02091524 0,0507973 ! purine base metabolic process GO:0006144 18 9 0,000 0,02091524 0,05074371 ! oocyte differentiation GO:0009994 12 9 0,000 0,02091524 0,05069024 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02091524 0,05063689 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02091524 0,05058364 ! spleen development GO:0048536 15 9 0,000 0,02091524 0,05053051 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02091524 0,05047748 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02091524 0,05042457 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02091524 0,05037177 ! detection of calcium ion GO:0005513 13 9 0,000 0,02091524 0,05031908 ! blastocyst formation GO:0001825 12 9 0,000 0,02091524 0,0502665 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02091524 0,05021403 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02091524 0,05016167 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02091524 0,05010942 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02091524 0,05005727 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02091524 0,05000524 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02091524 0,04995331 ! prepulse inhibition GO:0060134 14 9 0,000 0,02091524 0,0499015 ! embryonic placenta development GO:0001892 12 9 0,000 0,02091524 0,04984978 ! insulin secretion GO:0030073 17 9 0,000 0,02091524 0,04979818 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02091524 0,04974668 ! response to nicotine GO:0035094 16 9 0,000 0,02091524 0,04969529 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02091524 0,04964401 ! nucleus localization GO:0051647 15 9 0,000 0,02091524 0,04959283 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02091524 0,04954175 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,02129597 0,0503917 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,02129597 0,05033991 ! response to light stimulus GO:0009416 153 96 1,000 0,02129597 0,05028823 ! calcium ion transport GO:0006816 167 99 1,000 0,02255546 0,05320775 ! divalent metal ion transport GO:0070838 171 100 1,000 0,02298203 0,05415848 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02321264 0,05464592 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02321264 0,05459004 ! neuron fate specification GO:0048665 11 10 0,000 0,02321264 0,05453428 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02321264 0,05447863 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02321264 0,0544231 ! thyroid gland development GO:0030878 19 10 0,000 0,02321264 0,05436768 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,02321264 0,05431237 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02321264 0,05425718 ! synapsis GO:0007129 13 10 0,000 0,02321264 0,05420209 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02321264 0,05414712 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02321264 0,05409226 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02321264 0,05403751 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02321264 0,05398287 ! sulfate transport GO:0008272 12 10 0,000 0,02321264 0,05392835 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02321264 0,05387393 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02321264 0,05381962 ! androgen metabolic process GO:0008209 13 10 0,000 0,02321264 0,05376542 ! phospholipid efflux GO:0033700 16 10 0,000 0,02321264 0,05371133 ! hippocampus development GO:0021766 19 10 0,000 0,02321264 0,05365735 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02321264 0,05360348 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02321264 0,05354971 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02321264 0,05349605 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02321264 0,0534425 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02321264 0,05338906 ! pathogenesis GO:0009405 13 10 0,000 0,02321264 0,05333573 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02321264 0,0532825 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02321264 0,05322937 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02321264 0,05317636 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02321264 0,05312344 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02321264 0,05307064 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02321264 0,05301794 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02321264 0,05296534 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02321264 0,05291285 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02321264 0,05286046 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02321264 0,05280817 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02321264 0,05275599 ! response to X-ray GO:0010165 16 10 0,000 0,02321264 0,05270391 ! B cell proliferation GO:0042100 14 10 0,000 0,02321264 0,05265193 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02321264 0,05260006 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02321264 0,05254829 ! forebrain cell migration GO:0021885 17 10 0,000 0,02321264 0,05249662 ! lipid digestion GO:0044241 15 10 0,000 0,02321264 0,05244505 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02321264 0,05239358 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02321264 0,05234222 ! UV protection GO:0009650 14 10 0,000 0,02321264 0,05229095 ! entry into host cell GO:0030260 20 10 0,000 0,02321264 0,05223979 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02321264 0,05218872 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02321264 0,05213776 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02321264 0,05208689 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02321264 0,05203612 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02321264 0,05198545 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02321264 0,05193489 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02321264 0,05188441 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02321264 0,05183404 ! regulation of organ growth GO:0046620 11 10 0,000 0,02321264 0,05178377 ! response to dsRNA GO:0043331 18 10 0,000 0,02321264 0,05173359 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02321264 0,05168351 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02321264 0,05163352 ! embryonic axis specification GO:0000578 12 10 0,000 0,02321264 0,05158363 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02321264 0,05153384 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02321264 0,05148415 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02321264 0,05143455 ! cranial nerve development GO:0021545 12 10 0,000 0,02321264 0,05138505 ! fucose catabolic process GO:0019317 16 10 0,000 0,02321264 0,05133564 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02321264 0,05128632 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02321264 0,0512371 ! protein sumoylation GO:0016925 12 10 0,000 0,02321264 0,05118798 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02321264 0,05113895 ! zymogen activation GO:0031638 14 10 0,000 0,02321264 0,05109001 ! salivary gland development GO:0007431 22 10 0,000 0,02321264 0,05104117 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02321264 0,05099242 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02321264 0,05094376 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02321264 0,0508952 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02321264 0,05084673 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02321264 0,05079835 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02321264 0,05075006 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02321264 0,05070186 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02321264 0,05065376 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02321264 0,05060575 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,02321264 0,05055782 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02321264 0,05050999 ! detection of bacterium GO:0016045 10 10 0,000 0,02321264 0,05046225 ! embryonic gut development GO:0048566 11 10 0,000 0,02321264 0,0504146 ! activation of innate immune response GO:0002218 10 10 0,000 0,02321264 0,05036704 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02321264 0,05031957 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02321264 0,05027219 ! developmental induction GO:0031128 13 10 0,000 0,02321264 0,05022489 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02321264 0,05017769 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02321264 0,05013057 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02321264 0,05008355 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,02321264 0,05003661 ! rRNA transcription GO:0009303 17 11 0,000 0,02550478 0,05492602 ! respiratory burst GO:0045730 14 11 0,000 0,02550478 0,05487464 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,02550478 0,05482335 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,02550478 0,05477216 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,02550478 0,05472107 ! virus-host interaction GO:0019048 17 11 0,000 0,02550478 0,05467007 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,02550478 0,05461917 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,02550478 0,05456836 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,02550478 0,05451764 ! RNA polyadenylation GO:0043631 19 11 0,000 0,02550478 0,05446702 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,02550478 0,0544165 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,02550478 0,05436607 ! mating GO:0007618 14 11 0,000 0,02550478 0,05431573 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,02550478 0,05426548 ! T cell proliferation GO:0042098 20 11 0,000 0,02550478 0,05421533 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,02550478 0,05416527 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,02550478 0,0541153 ! bone resorption GO:0045453 16 11 0,000 0,02550478 0,05406542 ! regulated secretory pathway GO:0045055 14 11 0,000 0,02550478 0,05401564 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,02550478 0,05396595 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,02550478 0,05391635 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,02550478 0,05386684 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,02550478 0,05381742 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,02550478 0,05376809 ! syncytium formation GO:0006949 15 11 0,000 0,02550478 0,05371885 ! plasma membrane organization GO:0007009 18 11 0,000 0,02550478 0,0536697 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,02550478 0,05362064 ! focal adhesion formation GO:0048041 24 11 0,000 0,02550478 0,05357168 ! mitotic spindle organization GO:0007052 15 11 0,000 0,02550478 0,0535228 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,02550478 0,05347401 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,02550478 0,05342531 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,02550478 0,05337669 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,02550478 0,05332817 ! adult heart development GO:0007512 11 11 0,000 0,02550478 0,05327973 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,02550478 0,05323138 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,02550478 0,05318312 ! temperature homeostasis GO:0001659 16 11 0,000 0,02550478 0,05313495 ! L-glutamate transport GO:0015813 16 11 0,000 0,02550478 0,05308686 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,02550478 0,05303887 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,02550478 0,05299095 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,02550478 0,05294313 ! stem cell development GO:0048864 29 11 0,000 0,02550478 0,05289539 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,02550478 0,05284773 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,02550478 0,05280017 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,02550478 0,05275268 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,02550478 0,05270529 ! vasoconstriction GO:0042310 15 11 0,000 0,02550478 0,05265798 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,02550478 0,05261075 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,02550478 0,05256361 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,02550478 0,05251655 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,02550478 0,05246958 ! ribosome assembly GO:0042255 13 11 0,000 0,02550478 0,05242269 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,02550478 0,05237588 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,02550478 0,05232916 ! chromatin silencing GO:0006342 19 11 0,000 0,02550478 0,05228252 ! nucleosome positioning GO:0016584 13 11 0,000 0,02550478 0,05223596 ! T cell homeostasis GO:0043029 20 11 0,000 0,02550478 0,05218949 ! regulation of isotype switching GO:0045191 19 11 0,000 0,02550478 0,0521431 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,02550478 0,05209679 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,02550478 0,05205056 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,02550478 0,05200442 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,02550478 0,05195836 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,02550478 0,05191238 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,02550478 0,05186648 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,02550478 0,05182066 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,02550478 0,05177492 ! male genitalia development GO:0030539 13 11 0,000 0,02550478 0,05172926 ! cholesterol efflux GO:0033344 19 11 0,000 0,02550478 0,05168369 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,02550478 0,05163819 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,02550478 0,05159278 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,02550478 0,05154744 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,02550478 0,05150218 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,02550478 0,051457 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,02550478 0,05141191 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,02550478 0,05136689 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,02550478 0,05132195 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,02550478 0,05127709 ! lysogeny GO:0030069 18 11 0,000 0,02550478 0,0512323 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,02550478 0,0511876 ! acrosome reaction GO:0007340 13 11 0,000 0,02550478 0,05114297 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,02550478 0,05109842 ! lactation GO:0007595 20 12 0,000 0,02779167 0,05563171 ! reproductive cellular process GO:0048610 14 12 0,000 0,02779167 0,05558334 ! tRNA modification GO:0006400 14 12 0,000 0,02779167 0,05553505 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,02779167 0,05548684 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,02779167 0,05543872 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,02779167 0,05539068 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,02779167 0,05534272 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,02779167 0,05529484 ! non-recombinational repair GO:0000726 19 12 0,000 0,02779167 0,05524705 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,02779167 0,05519934 ! peroxisomal transport GO:0043574 21 12 0,000 0,02779167 0,05515172 ! cartilage condensation GO:0001502 18 12 0,000 0,02779167 0,05510417 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,02779167 0,05505671 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,02779167 0,05500933 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,02779167 0,05496203 ! heart looping GO:0001947 15 12 0,000 0,02779167 0,05491481 ! palate development GO:0060021 15 12 0,000 0,02779167 0,05486767 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,02779167 0,05482062 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,02779167 0,05477364 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,02779167 0,05472675 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,02779167 0,05467993 ! arginine metabolic process GO:0006525 13 12 0,000 0,02779167 0,0546332 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,02779167 0,05458654 ! methionine metabolic process GO:0006555 13 12 0,000 0,02779167 0,05453996 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,02779167 0,05449347 ! Golgi organization GO:0007030 18 12 0,000 0,02779167 0,05444705 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,02779167 0,05440071 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,02779167 0,05435445 ! monoamine transport GO:0015844 13 12 0,000 0,02779167 0,05430827 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02779167 0,05426217 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,02779167 0,05421615 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,02779167 0,0541702 ! L-amino acid transport GO:0015807 20 12 0,000 0,02779167 0,05412433 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,02779167 0,05407854 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,02779167 0,05403283 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,02779167 0,0539872 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,02779167 0,05394164 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,02779167 0,05389615 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,02779167 0,05385075 ! cerebellum development GO:0021549 13 12 0,000 0,02779167 0,05380542 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,02779167 0,05376017 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,02779167 0,05371499 ! histone acetylation GO:0016573 23 12 0,000 0,02779167 0,05366989 ! histone methylation GO:0016571 15 12 0,000 0,02779167 0,05362486 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,02779167 0,05357992 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,02779167 0,05353504 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,02779167 0,05349024 ! response to gamma radiation GO:0010332 20 12 0,000 0,02779167 0,05344552 ! regulation of epidermis development GO:0045682 17 12 0,000 0,02779167 0,05340087 ! intestinal absorption GO:0050892 19 12 0,000 0,02779167 0,05335629 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,02779167 0,05331179 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,02779167 0,05326737 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,02779167 0,05322301 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,02779167 0,05317873 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,02779167 0,05313453 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,02779167 0,0530904 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,02779167 0,05304634 ! microspike assembly GO:0030035 23 12 0,000 0,02779167 0,05300235 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,02779167 0,05295844 ! response to cold GO:0009409 14 12 0,000 0,02779167 0,0529146 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,03007333 0,05721146 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,03007333 0,05716417 ! cGMP metabolic process GO:0046068 16 13 0,000 0,03007333 0,05711697 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,03007333 0,05706984 ! water transport GO:0006833 17 13 0,000 0,03007333 0,05702279 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,03007333 0,05697582 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,03007333 0,05692893 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,03007333 0,05688211 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,03007333 0,05683537 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,03007333 0,05678871 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,03007333 0,05674212 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,03007333 0,05669561 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,03007333 0,05664918 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,03007333 0,05660282 ! response to hexose stimulus GO:0009746 19 13 0,000 0,03007333 0,05655654 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,03007333 0,05651033 ! glutamate metabolic process GO:0006536 18 13 0,000 0,03007333 0,0564642 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,03007333 0,05641815 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,03007333 0,05637217 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,03007333 0,05632626 ! NAD metabolic process GO:0019674 21 13 0,000 0,03007333 0,05628043 ! exocrine system development GO:0035272 27 13 0,000 0,03007333 0,05623467 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,03007333 0,05618899 ! bone mineralization GO:0030282 15 13 0,000 0,03007333 0,05614338 ! regulation of exocytosis GO:0017157 17 13 0,000 0,03007333 0,05609785 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,03007333 0,05605239 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,03007333 0,056007 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,03007333 0,05596169 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,03007333 0,05591645 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,03007333 0,05587128 ! genitalia development GO:0048806 15 13 0,000 0,03007333 0,05582619 ! regulation of cellular pH GO:0030641 20 13 0,000 0,03007333 0,05578117 ! cellular pigmentation GO:0033059 24 13 0,000 0,03007333 0,05573622 ! tissue regeneration GO:0042246 21 13 0,000 0,03007333 0,05569134 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,03007333 0,05564654 ! cofactor transport GO:0051181 19 13 0,000 0,03007333 0,05560181 ! NADP metabolic process GO:0006739 18 13 0,000 0,03007333 0,05555715 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,03007333 0,05551256 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,03007333 0,05546804 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03007333 0,0554236 ! gas transport GO:0015669 18 13 0,000 0,03007333 0,05537922 ! regulation of RNA stability GO:0043487 28 13 0,000 0,03007333 0,05533492 ! heme biosynthetic process GO:0006783 20 13 0,000 0,03007333 0,05529069 ! regulation of axon extension GO:0030516 23 13 0,000 0,03007333 0,05524652 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,03007333 0,05520243 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,03007333 0,05515841 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,03007333 0,05511446 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,03007333 0,05507058 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,03007333 0,05502677 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,03007333 0,05498303 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,03234976 0,05909805 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,03234976 0,05905115 ! superoxide anion generation GO:0042554 18 14 0,000 0,03234976 0,05900432 ! regulation of S phase GO:0033261 18 14 0,000 0,03234976 0,05895756 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,03234976 0,05891088 ! myotube differentiation GO:0014902 21 14 0,000 0,03234976 0,05886427 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,03234976 0,05881774 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,03234976 0,05877128 ! inositol metabolic process GO:0006020 20 14 0,000 0,03234976 0,0587249 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,03234976 0,05867858 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,03234976 0,05863234 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,03234976 0,05858618 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,03234976 0,05854008 ! gene silencing by RNA GO:0031047 20 14 0,000 0,03234976 0,05849406 ! response to cAMP GO:0051591 19 14 0,000 0,03234976 0,05844811 ! limbic system development GO:0021761 25 14 0,000 0,03234976 0,05840223 ! startle response GO:0001964 21 14 0,000 0,03234976 0,05835643 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,03234976 0,05831069 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,03234976 0,05826503 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,03234976 0,05821944 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,03234976 0,05817392 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,03234976 0,05812847 ! glycine metabolic process GO:0006544 22 14 0,000 0,03234976 0,05808309 ! pituitary gland development GO:0021983 23 14 0,000 0,03234976 0,05803779 ! cellular response to starvation GO:0009267 21 14 0,000 0,03234976 0,05799255 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,03234976 0,05794739 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,03234976 0,05790229 ! regulation of heart rate GO:0002027 23 14 0,000 0,03234976 0,05785727 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,03234976 0,05781231 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,03234976 0,05776742 ! embryo implantation GO:0007566 27 14 0,000 0,03234976 0,05772261 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,03234976 0,05767786 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,03234976 0,05763319 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,03234976 0,05758858 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,03234976 0,05754404 ! axon cargo transport GO:0008088 27 14 0,000 0,03234976 0,05749957 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,03234976 0,05745517 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,03234976 0,05741084 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,03234976 0,05736657 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,03234976 0,05732238 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03234976 0,05727825 ! mRNA splice site selection GO:0006376 26 14 0,000 0,03234976 0,05723419 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,03234976 0,05719019 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,03234976 0,05714627 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,03234976 0,05710241 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,03234976 0,05705862 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,03234976 0,0570149 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,03234976 0,05697124 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,03234976 0,05692765 ! muscle maintenance GO:0046716 19 14 0,000 0,03234976 0,05688413 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,03234976 0,05684067 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,03234976 0,05679728 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,03234976 0,05675396 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,03234976 0,0567107 ! cell killing GO:0001906 20 14 0,000 0,03234976 0,05666751 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,03234976 0,05662439 ! cilium assembly GO:0042384 20 14 0,000 0,03234976 0,05658133 ! peptide hormone secretion GO:0030072 23 14 0,000 0,03234976 0,05653833 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,03462098 0,06046184 ! positive regulation of cell size GO:0045793 20 15 0,000 0,03462098 0,06041597 ! metencephalon development GO:0022037 19 15 0,000 0,03462098 0,06037017 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,03462098 0,06032443 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,03462098 0,06027876 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,03462098 0,06023317 ! skin development GO:0043588 25 15 0,000 0,03462098 0,06018764 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,03462098 0,06014218 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,03462098 0,06009679 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,03462098 0,06005147 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,03462098 0,06000622 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,03462098 0,05996103 ! bile acid metabolic process GO:0008206 22 15 0,000 0,03462098 0,05991591 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,03462098 0,05987086 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,03462098 0,05982588 ! adult walking behavior GO:0007628 25 15 0,000 0,03462098 0,05978097 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,03462098 0,05973612 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,03462098 0,05969134 ! centrosome cycle GO:0007098 16 15 0,000 0,03462098 0,05964663 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,03462098 0,05960198 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,03462098 0,0595574 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,03462098 0,05951289 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,03462098 0,05946844 ! cerebral cortex development GO:0021987 29 15 0,000 0,03462098 0,05942407 ! response to osmotic stress GO:0006970 22 15 0,000 0,03462098 0,05937975 ! vesicle coating GO:0006901 25 15 0,000 0,03462098 0,05933551 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,03462098 0,05929132 ! DNA integration GO:0015074 22 15 0,000 0,03462098 0,05924721 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,03462098 0,05920316 ! peptide secretion GO:0002790 27 15 0,000 0,03462098 0,05915917 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,03462098 0,05911525 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,03462098 0,0590714 ! neuron recognition GO:0008038 22 15 0,000 0,03462098 0,05902761 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,03462098 0,05898389 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,03462098 0,05894023 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,03462098 0,05889663 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,03462098 0,0588531 ! biomineral formation GO:0031214 18 15 0,000 0,03462098 0,05880964 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,03462098 0,05876623 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,03462098 0,0587229 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,03462098 0,05867962 ! dopamine metabolic process GO:0042417 30 15 0,000 0,03462098 0,05863641 ! organic cation transport GO:0015695 19 15 0,000 0,03462098 0,05859327 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,03462098 0,05855018 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,03462098 0,05850716 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,03462098 0,05846421 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,03462098 0,05842131 ! defense response to virus GO:0051607 27 15 0,000 0,03462098 0,05837848 ! peptide hormone processing GO:0016486 19 15 0,000 0,03462098 0,05833571 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,03462098 0,05829301 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,036887 0,06206298 ! hormone secretion GO:0046879 25 16 0,000 0,036887 0,06201761 ! bone remodeling GO:0046849 24 16 0,000 0,036887 0,06197231 ! endothelial cell migration GO:0043542 22 16 0,000 0,036887 0,06192707 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,036887 0,0618819 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,036887 0,0618368 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,036887 0,06179176 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,036887 0,06174679 ! glial cell development GO:0021782 24 16 0,000 0,036887 0,06170188 ! patterning of blood vessels GO:0001569 24 16 0,000 0,036887 0,06165704 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,036887 0,06161227 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,036887 0,06156755 ! protein polyubiquitination GO:0000209 26 16 0,000 0,036887 0,06152291 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,036887 0,06147833 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,036887 0,06143381 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,036887 0,06138936 ! fructose metabolic process GO:0006000 20 16 0,000 0,036887 0,06134497 ! regulation of protein binding GO:0043393 27 16 0,000 0,036887 0,06130064 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,036887 0,06125638 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,036887 0,06121219 ! protein export from nucleus GO:0006611 24 16 0,000 0,036887 0,06116805 ! negative regulation of immune response GO:0050777 28 16 0,000 0,036887 0,06112398 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,036887 0,06107998 ! DNA replication initiation GO:0006270 25 16 0,000 0,036887 0,06103604 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,036887 0,06099216 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,036887 0,06094834 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,036887 0,06090459 ! diencephalon development GO:0021536 25 16 0,000 0,036887 0,0608609 ! oogenesis GO:0048477 23 16 0,000 0,036887 0,06081727 ! G1 phase GO:0051318 27 16 0,000 0,036887 0,0607737 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,036887 0,0607302 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,036887 0,06068676 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,036887 0,06064338 ! steroid catabolic process GO:0006706 22 16 0,000 0,036887 0,06060006 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,036887 0,06055681 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,036887 0,06051362 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,036887 0,06047048 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,036887 0,06042741 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,036887 0,06038441 ! sperm-egg recognition GO:0035036 16 16 0,000 0,036887 0,06034146 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,036887 0,06029857 ! nerve development GO:0021675 18 16 0,000 0,036887 0,06025575 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,036887 0,06021298 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,036887 0,06017028 ! negative regulation of translation GO:0017148 22 16 0,000 0,036887 0,06012763 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,03914782 0,0637677 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,03914782 0,06372257 ! negative regulation of defense response GO:0031348 19 17 0,000 0,03914782 0,06367751 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,03914782 0,06363251 ! glycerol metabolic process GO:0006071 20 17 0,000 0,03914782 0,06358757 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,03914782 0,06354269 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,03914782 0,06349788 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,03914782 0,06345313 ! signal complex assembly GO:0007172 29 17 0,000 0,03914782 0,06340845 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,03914782 0,06336383 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,03914782 0,06331927 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,03914782 0,06327477 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,03914782 0,06323033 ! memory GO:0007613 25 17 0,000 0,03914782 0,06318596 ! keratinization GO:0031424 17 17 0,000 0,03914782 0,06314165 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,03914782 0,0630974 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,03914782 0,06305322 ! retinoid metabolic process GO:0001523 22 17 0,000 0,03914782 0,06300909 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,03914782 0,06296503 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,03914782 0,06292103 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,03914782 0,06287709 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,03914782 0,06283321 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,03914782 0,0627894 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,03914782 0,06274564 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,03914782 0,06270195 ! membrane budding GO:0006900 29 17 0,000 0,03914782 0,06265831 ! heme metabolic process GO:0042168 27 17 0,000 0,03914782 0,06261474 ! actin filament bundle formation GO:0051017 26 17 0,000 0,03914782 0,06257123 ! neuromuscular junction development GO:0007528 23 17 0,000 0,03914782 0,06252777 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,03914782 0,06248438 ! body fluid secretion GO:0007589 27 17 0,000 0,03914782 0,06244105 ! stem cell differentiation GO:0048863 36 17 0,000 0,03914782 0,06239778 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,03914782 0,06235457 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,03914782 0,06231142 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,03914782 0,06226832 ! sensory perception of pain GO:0019233 23 17 0,000 0,03914782 0,06222529 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,03914782 0,06218232 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,03914782 0,0621394 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,03914782 0,06209655 ! synaptogenesis GO:0007416 24 17 0,000 0,03914782 0,06205375 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,03914782 0,06201102 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,03914782 0,06196834 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,03914782 0,06192572 ! cell-cell junction organization GO:0045216 25 17 0,000 0,03914782 0,06188316 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,03914782 0,06184066 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,03914782 0,06179821 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,03914782 0,06175583 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,03914782 0,0617135 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,03914782 0,06167123 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,03914782 0,06162902 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,04140347 0,06513543 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,04140347 0,0650909 ! positive regulation of translation GO:0045727 28 18 0,000 0,04140347 0,06504644 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,04140347 0,06500204 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,04140347 0,0649577 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,04140347 0,06491342 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,04140347 0,0648692 ! cAMP metabolic process GO:0046058 33 18 0,000 0,04140347 0,06482505 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,04140347 0,06478095 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,04140347 0,06473691 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,04140347 0,06469293 ! axis specification GO:0009798 26 18 0,000 0,04140347 0,06464901 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,04140347 0,06460515 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,04140347 0,06456135 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,04140347 0,06451761 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,04140347 0,06447393 ! glutamine metabolic process GO:0006541 23 18 0,000 0,04140347 0,06443031 ! response to retinoic acid GO:0032526 25 18 0,000 0,04140347 0,06438674 ! pigmentation during development GO:0048066 31 18 0,000 0,04140347 0,06434324 ! central nervous system neuron development GO:0021954 30 18 0,000 0,04140347 0,06429979 ! fucose metabolic process GO:0006004 26 18 0,000 0,04140347 0,0642564 ! response to fungus GO:0009620 19 18 0,000 0,04140347 0,06421308 ! peptide cross-linking GO:0018149 31 18 0,000 0,04140347 0,06416981 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,04140347 0,06412659 ! heart process GO:0003015 27 18 0,000 0,04140347 0,06408344 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,04140347 0,06404034 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,04140347 0,06399731 ! visual learning GO:0008542 35 18 0,000 0,04140347 0,06395433 ! somitogenesis GO:0001756 24 18 0,000 0,04140347 0,0639114 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,04140347 0,06386854 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,04140347 0,06382573 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,04140347 0,06378298 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,04140347 0,06374029 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,04140347 0,06369765 ! vitamin transport GO:0051180 24 18 0,000 0,04140347 0,06365507 ! hormone transport GO:0009914 27 18 0,000 0,04140347 0,06361255 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,04140347 0,06357009 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,04140347 0,06352768 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,04140347 0,06348533 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,04140347 0,06344303 ! cell-cell recognition GO:0009988 20 18 0,000 0,04140347 0,06340079 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,04140347 0,06335861 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,04140347 0,06331648 ! regulation of glucose import GO:0046324 21 18 0,000 0,04140347 0,06327441 GO:0010827|regulation of glucose transport, ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,04140347 0,0632324 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,04140347 0,06319044 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,04140347 0,06314854 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,04365396 0,06653685 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,04365396 0,06649279 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,04365396 0,06644878 ! positive regulation of ossification GO:0045778 30 19 0,000 0,04365396 0,06640483 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,04365396 0,06636094 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,04365396 0,06631711 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,04365396 0,06627334 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,04365396 0,06622962 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,04365396 0,06618596 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,04365396 0,06614236 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,04365396 0,06609882 ! regeneration GO:0031099 32 19 0,000 0,04365396 0,06605533 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,04365396 0,0660119 ! response to alkaloid GO:0043279 32 19 0,000 0,04365396 0,06596853 ! sensory perception of taste GO:0050909 23 19 0,000 0,04365396 0,06592522 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,04365396 0,06588196 ! smooth muscle contraction GO:0006939 36 19 0,000 0,04365396 0,06583876 ! peroxisome organization GO:0007031 29 19 0,000 0,04365396 0,06579561 ! digestive system process GO:0022600 30 19 0,000 0,04365396 0,06575253 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,04365396 0,06570949 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,04365396 0,06566652 ! response to vitamin A GO:0033189 26 19 0,000 0,04365396 0,0656236 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,04365396 0,06558074 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,04365396 0,06553793 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,04365396 0,06549518 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,04365396 0,06545248 ! response to starvation GO:0042594 30 19 0,000 0,04365396 0,06540984 ! sex determination GO:0007530 29 19 0,000 0,04365396 0,06536726 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,04365396 0,06532473 ! plasma membrane fusion GO:0045026 23 19 0,000 0,04365396 0,06528225 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,04365396 0,06523983 ! cytolysis GO:0019835 20 19 0,000 0,04365396 0,06519747 ! renal system process GO:0003014 35 19 0,000 0,04365396 0,06515516 ! vasodilation GO:0042311 33 19 0,000 0,04365396 0,06511291 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,04365396 0,06507071 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,04365396 0,06502857 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,04365396 0,06498648 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,04365396 0,06494444 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,04365396 0,06490246 ! sarcomere organization GO:0045214 23 19 0,000 0,04365396 0,06486053 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,04365396 0,06481866 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,04365396 0,06477684 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,04365396 0,06473508 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,04365396 0,06469337 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,04365396 0,06465171 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,04365396 0,06461011 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,04365396 0,06456856 ! protein stabilization GO:0050821 26 19 0,000 0,04365396 0,06452706 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,04589929 0,06780242 ! iron ion transport GO:0006826 37 20 0,000 0,04589929 0,0677589 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,04589929 0,06771544 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,04589929 0,06767203 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,04589929 0,06762868 ! response to vitamin GO:0033273 29 20 0,000 0,04589929 0,06758538 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,04589929 0,06754214 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,04589929 0,06749895 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,04589929 0,06745582 ! spinal cord development GO:0021510 31 20 0,000 0,04589929 0,06741275 ! response to ethanol GO:0045471 37 20 0,000 0,04589929 0,06736973 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,04589929 0,06732676 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,04589929 0,06728385 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,04589929 0,067241 ! chromosome condensation GO:0030261 31 20 0,000 0,04589929 0,06719819 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,04589929 0,06715545 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,04589929 0,06711276 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,04589929 0,06707012 ! pallium development GO:0021543 38 20 0,000 0,04589929 0,06702753 ! DNA modification GO:0006304 28 20 0,000 0,04589929 0,066985 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,04589929 0,06694253 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,04589929 0,0669001 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,04589929 0,06685774 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,04589929 0,06681542 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,04589929 0,06677316 ! collagen catabolic process GO:0030574 25 20 0,000 0,04589929 0,06673095 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,04589929 0,0666888 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,04589929 0,06664669 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,04589929 0,06660465 ! alditol metabolic process GO:0019400 24 20 0,000 0,04589929 0,06656265 ! actin filament-based movement GO:0030048 34 20 0,000 0,04589929 0,06652071 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,04813947 0,06972342 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,04813947 0,06967954 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,04813947 0,06963572 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,04813947 0,06959195 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,04813947 0,06954824 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,04813947 0,06950458 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,04813947 0,06946097 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,04813947 0,06941742 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,04813947 0,06937393 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,04813947 0,06933049 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,04813947 0,0692871 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,04813947 0,06924377 ! protein amino acid acylation GO:0043543 37 21 0,000 0,04813947 0,06920049 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,04813947 0,06915727 ! phototransduction GO:0007602 25 21 0,000 0,04813947 0,0691141 ! dendrite development GO:0016358 35 21 0,000 0,04813947 0,06907099 ! visual behavior GO:0007632 39 21 0,000 0,04813947 0,06902792 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,04813947 0,06898492 ! ovarian follicle development GO:0001541 30 21 0,000 0,04813947 0,06894196 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,04813947 0,06889906 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,04813947 0,06885621 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,04813947 0,06881342 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,04813947 0,06877068 ! cell aging GO:0007569 32 21 0,000 0,04813947 0,06872799 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,04813947 0,06868535 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,04813947 0,06864277 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,04813947 0,06860024 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,04813947 0,06855777 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,04813947 0,06851534 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,04813947 0,06847297 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,04813947 0,06843065 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,04813947 0,06838838 ! fatty acid transport GO:0015908 30 21 0,000 0,04813947 0,06834617 ! immunoglobulin production GO:0002377 33 21 0,000 0,04813947 0,068304 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,04813947 0,06826189 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,04813947 0,06821983 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,04813947 0,06817783 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,04813947 0,06813587 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,04813947 0,06809397 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,04813947 0,06805212 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,04813947 0,06801031 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,04813947 0,06796856 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,04813947 0,06792687 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,04813947 0,06788522 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,04813947 0,06784362 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,04813947 0,06780208 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,04813947 0,06776058 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,04813947 0,06771914 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,04813947 0,06767775 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,05037453 0,07077667 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,05037453 0,07073347 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,05037453 0,07069031 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,05037453 0,07064721 ! viral genome replication GO:0019079 29 22 0,000 0,05037453 0,07060415 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,05037453 0,07056115 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,05037453 0,07051821 ! leukocyte adhesion GO:0007159 38 22 0,000 0,05037453 0,07047531 ! molting cycle process GO:0022404 40 22 0,000 0,05037453 0,07043247 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,05037453 0,07038968 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,05037453 0,07034694 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,05037453 0,07030426 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,05037453 0,07026162 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,05037453 0,07021904 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,05037453 0,07017651 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,05037453 0,07013403 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,05037453 0,0700916 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,05037453 0,07004922 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,05037453 0,0700069 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,05037453 0,06996462 ! regulation of behavior GO:0050795 38 22 0,000 0,05037453 0,0699224 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,05037453 0,06988023 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,05037453 0,06983811 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,05037453 0,06979603 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,05037453 0,06975401 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,05037453 0,06971204 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,05037453 0,06967012 ! blastocyst development GO:0001824 37 22 0,000 0,05037453 0,06962825 ! neural tube closure GO:0001843 33 22 0,000 0,05037453 0,06958644 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,05037453 0,06954467 ! protein tetramerization GO:0051262 39 22 0,000 0,05037453 0,06950295 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,05260446 0,07253613 ! neuron fate commitment GO:0048663 32 23 0,000 0,05260446 0,07249267 ! embryonic pattern specification GO:0009880 31 23 0,000 0,05260446 0,07244926 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,05260446 0,0724059 ! myelination GO:0042552 35 23 0,000 0,05260446 0,0723626 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,05260446 0,07231934 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,05260446 0,07227614 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,05260446 0,07223299 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,05260446 0,0721899 ! vesicle targeting GO:0006903 32 23 0,000 0,05260446 0,07214685 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,05260446 0,07210385 ! osteoblast differentiation GO:0001649 40 23 0,000 0,05260446 0,07206091 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,05260446 0,07201801 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,05260446 0,07197517 ! interaction with host GO:0051701 37 23 0,000 0,05260446 0,07193238 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,05260446 0,07188964 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,05260446 0,07184695 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,05260446 0,07180431 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,05260446 0,07176172 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,05260446 0,07171918 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,05260446 0,0716767 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,05260446 0,07163426 ! cell fate determination GO:0001709 45 23 0,000 0,05260446 0,07159187 ! pentose metabolic process GO:0019321 31 23 0,000 0,05260446 0,07154954 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,05260446 0,07150725 ! spermatid development GO:0007286 33 23 0,000 0,05260446 0,07146501 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,05260446 0,07142282 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,05260446 0,07138069 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,05260446 0,0713386 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,05260446 0,07129656 ! telomere organization GO:0032200 32 23 0,000 0,05260446 0,07125457 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,05260446 0,07121263 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,05260446 0,07117074 ! regulation of amine transport GO:0051952 38 23 0,000 0,05260446 0,0711289 ! liver development GO:0001889 40 23 0,000 0,05260446 0,07108711 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,05482929 0,07405012 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,05482929 0,07400667 ! initiation of viral infection GO:0019059 42 24 0,000 0,05482929 0,07396326 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,05482929 0,07391991 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,05482929 0,0738766 ! superoxide metabolic process GO:0006801 32 24 0,000 0,05482929 0,07383335 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,05482929 0,07379015 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,05482929 0,07374699 ! sperm motility GO:0030317 27 24 0,000 0,05482929 0,07370389 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,05482929 0,07366084 ! vacuole organization GO:0007033 39 24 0,000 0,05482929 0,07361784 ! receptor metabolic process GO:0043112 37 24 0,000 0,05482929 0,07357489 ! response to toxin GO:0009636 38 24 0,000 0,05482929 0,07353199 ! primary neural tube formation GO:0014020 35 24 0,000 0,05482929 0,07348914 ! negative regulation of cell development GO:0010721 56 24 0,000 0,05482929 0,07344634 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,05482929 0,07340359 ! base-excision repair GO:0006284 31 24 0,000 0,05482929 0,07336088 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,05482929 0,07331823 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,05482929 0,07327563 ! glutathione metabolic process GO:0006749 29 24 0,000 0,05482929 0,07323308 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,05482929 0,07319058 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,05482929 0,07314812 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,05704901 0,07606535 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,05704901 0,07602128 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,05704901 0,07597726 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,05704901 0,0759333 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,05704901 0,07588938 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,05704901 0,07584551 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,05704901 0,07580169 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 43 25 0,000 0,05704901 0,07575793 ! male gonad development GO:0008584 33 25 0,000 0,05704901 0,07571421 ! iron ion homeostasis GO:0055072 39 25 0,000 0,05704901 0,07567055 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,05704901 0,07562694 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,05704901 0,07558337 ! phospholipid transport GO:0015914 35 25 0,000 0,05704901 0,07553986 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,05704901 0,07549639 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,05704901 0,07545298 ! detection of light stimulus GO:0009583 30 25 0,000 0,05704901 0,07540962 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,05704901 0,0753663 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,05704901 0,07532304 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,05704901 0,07527982 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,05926366 0,07815734 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,05926366 0,07811256 ! translational initiation GO:0006413 43 26 0,000 0,05926366 0,07806782 ! regulation of pH GO:0006885 36 26 0,000 0,05926366 0,07802313 ! circadian rhythm GO:0007623 42 26 0,000 0,05926366 0,07797849 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,05926366 0,07793391 ! post-embryonic development GO:0009791 42 26 0,000 0,05926366 0,07788938 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,05926366 0,07784489 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,05926366 0,07780046 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,05926366 0,07775608 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,05926366 0,07771175 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,05926366 0,07766747 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,05926366 0,07762324 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,06147322 0,08047149 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,06147322 0,08042572 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,06147322 0,08037999 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,06147322 0,08033432 ! catechol metabolic process GO:0009712 43 27 0,000 0,06147322 0,08028871 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,06147322 0,08024314 ! acute-phase response GO:0006953 42 27 0,000 0,06147322 0,08019762 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,06147322 0,08015216 ! myofibril assembly GO:0030239 36 27 0,000 0,06147322 0,08010675 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,06147322 0,08006139 ! response to ionizing radiation GO:0010212 47 27 0,000 0,06147322 0,08001608 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,06147322 0,07997082 ! natural killer cell activation GO:0030101 35 27 0,000 0,06147322 0,07992561 ! lipid oxidation GO:0034440 38 27 0,000 0,06147322 0,07988046 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,06147322 0,07983535 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,06147322 0,0797903 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,06147322 0,0797453 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,06147322 0,07970034 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,06147322 0,07965544 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,06147322 0,07961059 ! gene silencing GO:0016458 41 27 0,000 0,06147322 0,07956579 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,06367773 0,08237276 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,06367773 0,08232646 ! phenol metabolic process GO:0018958 44 28 0,000 0,06367773 0,08228021 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,06367773 0,08223401 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,06367773 0,08218786 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,06367773 0,08214177 ! cell junction assembly GO:0034329 56 28 0,000 0,06367773 0,08209572 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,06367773 0,08204973 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,06367773 0,08200379 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,06367773 0,0819579 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,06367773 0,08191206 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,06367773 0,08186628 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,06367773 0,08182054 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,06367773 0,08177486 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,06367773 0,08172922 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,06367773 0,08168364 ! mesoderm formation GO:0001707 46 28 0,000 0,06367773 0,08163811 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,06367773 0,08159263 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,06367773 0,0815472 ! ensheathment of neurons GO:0007272 43 28 0,000 0,06367773 0,08150182 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,06367773 0,08145649 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,06367773 0,08141121 ! neural tube formation GO:0001841 41 28 0,000 0,06367773 0,08136598 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,06367773 0,0813208 ! placenta development GO:0001890 37 28 0,000 0,06367773 0,08127568 ! regulation of B cell activation GO:0050864 42 28 0,000 0,06367773 0,0812306 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,06587718 0,08398975 ! regulation of innate immune response GO:0045088 38 29 0,000 0,06587718 0,08394322 ! ovulation cycle process GO:0022602 41 29 0,000 0,06587718 0,08389674 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,06587718 0,08385031 ! protein targeting to membrane GO:0006612 53 29 0,000 0,06587718 0,08380393 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,06587718 0,0837576 ! muscle cell development GO:0055001 38 29 0,000 0,06587718 0,08371133 ! formation of primary germ layer GO:0001704 48 29 0,000 0,06587718 0,0836651 ! telencephalon development GO:0021537 52 29 0,000 0,06587718 0,08361893 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,06587718 0,08357281 ! eye morphogenesis GO:0048592 51 29 0,000 0,06587718 0,08352674 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,06587718 0,08348072 ! tissue homeostasis GO:0001894 42 29 0,000 0,06587718 0,08343475 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,06807159 0,08616656 ! collagen metabolic process GO:0032963 40 30 0,000 0,06807159 0,08611917 ! organic anion transport GO:0015711 51 30 0,000 0,06807159 0,08607182 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,06807159 0,08602453 ! spliceosome assembly GO:0000245 49 30 0,000 0,06807159 0,08597729 ! spindle organization GO:0007051 37 30 0,000 0,06807159 0,0859301 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,06807159 0,08588297 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,06807159 0,08583588 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,06807159 0,08578885 ! ceramide metabolic process GO:0006672 43 30 0,000 0,06807159 0,08574187 ! ovulation cycle GO:0042698 43 30 0,000 0,06807159 0,08569494 ! hindbrain development GO:0030902 45 30 0,000 0,06807159 0,08564806 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,06807159 0,08560123 ! adult locomotory behavior GO:0008344 47 30 0,000 0,06807159 0,08555445 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,06807159 0,08550773 ! response to heat GO:0009408 41 30 0,000 0,06807159 0,08546105 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,06807159 0,08541443 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,06807159 0,08536786 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,07026097 0,08806552 ! negative regulation of secretion GO:0051048 49 31 0,000 0,07026097 0,08801755 ! glial cell differentiation GO:0010001 55 31 0,000 0,07026097 0,08796964 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,07026097 0,08792177 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,07026097 0,08787397 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,07026097 0,08782621 ! odontogenesis GO:0042476 50 31 0,000 0,07026097 0,0877785 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,07026097 0,08773085 ! segmentation GO:0035282 41 31 0,000 0,07026097 0,08768325 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,07026097 0,0876357 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,07026097 0,0875882 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,07026097 0,08754075 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,07026097 0,08749335 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,07026097 0,08744601 ! cell fate specification GO:0001708 37 31 0,000 0,07026097 0,08739871 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,07026097 0,08735147 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,07026097 0,08730428 ! RNA modification GO:0009451 40 31 0,000 0,07026097 0,08725714 ! regulation of muscle development GO:0048634 48 32 0,000 0,07244533 0,08992135 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,07244533 0,08987284 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,07244533 0,0898244 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,07244533 0,089776 ! meiosis I GO:0007127 52 32 0,000 0,07244533 0,08972765 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,07244533 0,08967936 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,07244533 0,08963112 ! peripheral nervous system development GO:0007422 53 32 0,000 0,07244533 0,08958293 ! regulation of protein stability GO:0031647 48 32 0,000 0,07244533 0,0895348 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,07244533 0,08948671 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,07244533 0,08943868 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,07244533 0,08939069 ! vesicle localization GO:0051648 47 32 0,000 0,07244533 0,08934276 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,07462468 0,09198112 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,07462468 0,09193185 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,07462468 0,09188264 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,07462468 0,09183348 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,07462468 0,09178437 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,07462468 0,09173531 ! sister chromatid segregation GO:0000819 46 33 0,000 0,07462468 0,09168631 ! actomyosin structure organization GO:0031032 43 33 0,000 0,07462468 0,09163736 ! cell junction organization GO:0034330 63 33 0,000 0,07462468 0,09158846 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,07462468 0,09153961 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,07462468 0,09149082 ! nucleus organization GO:0006997 49 33 0,000 0,07462468 0,09144207 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,07462468 0,09139338 ! female gonad development GO:0008585 49 33 0,000 0,07462468 0,09134474 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,07462468 0,09129615 ! positive regulation of cell development GO:0010720 54 33 0,000 0,07462468 0,09124762 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,07462468 0,09119913 ! regulation of proteolysis GO:0030162 50 33 0,000 0,07462468 0,0911507 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,07462468 0,09110232 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,07462468 0,09105399 ! cytokinesis GO:0000910 52 33 0,000 0,07462468 0,09100571 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,07462468 0,09095748 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,07679904 0,09355815 ! mRNA catabolic process GO:0006402 48 34 0,000 0,07679904 0,09350863 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,07679904 0,09345915 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,07679904 0,09340973 ! feeding behavior GO:0007631 45 34 0,000 0,07679904 0,09336036 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,07679904 0,09331104 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,07679904 0,09326177 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,07679904 0,09321256 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,07679904 0,09316339 ! neuron migration GO:0001764 46 34 0,000 0,07679904 0,09311428 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,07679904 0,09306522 ! female gamete generation GO:0007292 43 34 0,000 0,07679904 0,09301622 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,07679904 0,09296726 ! polyol metabolic process GO:0019751 44 34 0,000 0,07679904 0,09291836 ! aerobic respiration GO:0009060 47 34 0,000 0,07679904 0,0928695 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,07679904 0,0928207 ! embryonic organ development GO:0048568 45 34 0,000 0,07679904 0,09277195 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,07679904 0,09272325 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,07896842 0,09529242 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,07896842 0,09524245 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,07896842 0,09519253 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,07896842 0,09514267 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,07896842 0,09509286 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,07896842 0,0950431 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,07896842 0,09499339 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,07896842 0,09494373 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,07896842 0,09489413 ! glycogen metabolic process GO:0005977 48 35 0,000 0,07896842 0,09484457 ! pigment metabolic process GO:0042440 61 35 0,000 0,07896842 0,09479507 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,07896842 0,09474562 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,08113282 0,0972917 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,08113282 0,097241 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,08113282 0,09719035 ! negative regulation of binding GO:0051100 58 36 0,000 0,08113282 0,09713976 ! neural tube development GO:0021915 50 36 0,000 0,08113282 0,09708922 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,08113282 0,09703873 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,08113282 0,09698829 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,08113282 0,09693791 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,08113282 0,09688758 ! glucan metabolic process GO:0044042 49 36 0,000 0,08113282 0,0968373 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,08329225 0,09936317 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,08329225 0,09931166 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,08329225 0,0992602 ! learning GO:0007612 67 37 0,000 0,08329225 0,0992088 ! ion transmembrane transport GO:0034220 56 37 0,000 0,08329225 0,09915745 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,08329225 0,09910615 ! regulation of protein secretion GO:0050708 51 37 0,000 0,08329225 0,0990549 ! amino acid activation GO:0043038 52 37 0,000 0,08329225 0,09900371 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,08329225 0,09895257 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,08544674 0,10145973 ! gliogenesis GO:0042063 71 38 0,000 0,08544674 0,10140738 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,08544674 0,10135508 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,08544674 0,10130284 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,08544674 0,10125065 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,08544674 0,10119851 ! phagocytosis GO:0006909 60 38 0,000 0,08544674 0,10114643 ! pigmentation GO:0043473 74 38 0,000 0,08544674 0,10109439 ! maintenance of location in cell GO:0051651 69 38 0,000 0,08544674 0,10104242 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,08759629 0,10353107 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,08759629 0,10347789 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,08759629 0,10342477 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,08759629 0,10337171 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,08759629 0,1033187 ! male sex differentiation GO:0046661 53 39 0,000 0,08759629 0,10326574 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,08759629 0,10321284 ! chromatin remodeling GO:0006338 68 39 0,000 0,08759629 0,10315999 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,08759629 0,1031072 ! JNK cascade GO:0007254 54 39 0,000 0,08759629 0,10305446 ! developmental growth GO:0048589 62 39 0,000 0,08759629 0,10300177 ! cell growth GO:0016049 61 39 0,000 0,08759629 0,10294914 ! synapse organization GO:0050808 55 39 0,000 0,08759629 0,10289656 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,0897409 0,10536196 ! response to calcium ion GO:0051592 58 40 0,000 0,0897409 0,1053082 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,0897409 0,1052545 ! regulation of tube size GO:0035150 60 40 0,000 0,0897409 0,10520086 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,0897409 0,10514726 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,0897409 0,10509373 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,0897409 0,10504024 ! peptide metabolic process GO:0006518 56 40 0,000 0,0897409 0,10498682 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,0897409 0,10493344 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,0897409 0,10488012 ! double-strand break repair GO:0006302 67 40 0,000 0,0897409 0,10482686 ! B cell differentiation GO:0030183 62 40 0,000 0,0897409 0,10477364 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,0897409 0,10472049 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,0897409 0,10466738 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,0897409 0,10461433 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,0918806 0,1070544 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,0918806 0,1070002 ! glucose transport GO:0015758 52 41 0,000 0,0918806 0,10694605 ! endosome transport GO:0016197 71 41 0,000 0,0918806 0,10689195 ! striated muscle contraction GO:0006941 62 41 0,000 0,0918806 0,10683791 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,0918806 0,10678392 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,0918806 0,10672999 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,0918806 0,10667612 ! biopolymer methylation GO:0043414 62 41 0,000 0,0918806 0,10662229 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,0918806 0,10656853 ! mitochondrial transport GO:0006839 60 42 0,000 0,09401539 0,10898962 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,09401539 0,10893471 ! cellular component disassembly GO:0022411 64 42 0,000 0,09401539 0,10887986 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,09401539 0,10882507 ! hexose transport GO:0008645 54 42 0,000 0,09401539 0,10877032 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,09401539 0,10871564 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,09401539 0,10866101 ! excretion GO:0007588 63 42 0,000 0,09401539 0,10860643 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,09401539 0,10855191 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,09401539 0,10849744 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,09401539 0,10844303 ! regulation of cell shape GO:0008360 78 42 0,000 0,09401539 0,10838867 ! positive regulation of binding GO:0051099 59 43 0,000 0,09614529 0,11078866 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,09614529 0,11073318 ! leukocyte migration GO:0050900 60 43 0,000 0,09614529 0,11067776 ! neuromuscular process GO:0050905 79 43 0,000 0,09614529 0,11062239 ! activation of caspase activity GO:0006919 65 43 0,000 0,09614529 0,11056708 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,09614529 0,11051183 ! tRNA processing GO:0008033 49 43 0,000 0,09614529 0,11045663 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,09614529 0,11040148 ! methylation GO:0032259 64 43 0,000 0,09614529 0,11034639 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,0982703 0,11272902 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,0982703 0,11267282 ! glycolysis GO:0006096 53 44 0,000 0,0982703 0,11261668 ! regulation of action potential GO:0001508 71 44 0,000 0,0982703 0,1125606 ! regulation of ion transport GO:0043269 57 44 0,000 0,0982703 0,11250457 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,0982703 0,1124486 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,0982703 0,11239268 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,0982703 0,11233682 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,0982703 0,11228102 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,0982703 0,11222527 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,0982703 0,11216957 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,0982703 0,11211393 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,0982703 0,11205835 ! RNA catabolic process GO:0006401 64 45 0,000 0,10039043 0,11441923 ! positive regulation of defense response GO:0031349 59 45 0,000 0,10039043 0,11436255 ! regulation of translational initiation GO:0006446 64 45 0,000 0,10039043 0,11430594 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,10039043 0,11424938 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,10039043 0,11419288 ! cell recognition GO:0008037 58 45 0,000 0,10039043 0,11413643 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,10250571 0,11648376 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,10250571 0,11642623 ! cell redox homeostasis GO:0045454 63 46 0,000 0,10250571 0,11636877 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,10250571 0,11631136 ! histone modification GO:0016570 68 46 0,000 0,10250571 0,11625401 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,10250571 0,11619671 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,10461612 0,11853058 ! viral infectious cycle GO:0019058 71 47 0,000 0,10461612 0,11847222 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,10461612 0,11841392 ! endocrine system development GO:0035270 83 47 0,000 0,10461612 0,11835567 ! covalent chromatin modification GO:0016569 75 47 0,000 0,10461612 0,11829749 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,10461612 0,11823935 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,10461612 0,11818128 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,10461612 0,11812326 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,10461612 0,1180653 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,10461612 0,1180074 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,10461612 0,11794955 ! chloride transport GO:0006821 67 48 0,000 0,1067217 0,12026453 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,1067217 0,12020564 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 0,000 0,1067217 0,1201468 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,1067217 0,12008802 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,1067217 0,1200293 ! gastrulation GO:0007369 73 48 0,000 0,1067217 0,11997063 ! heart morphogenesis GO:0003007 65 48 0,000 0,1067217 0,11991202 ! regulation of DNA replication GO:0006275 75 48 0,000 0,1067217 0,11985347 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,1067217 0,11979498 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,1067217 0,11973654 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,1067217 0,11967816 ! regulation of endocytosis GO:0030100 63 48 0,000 0,1067217 0,11961984 ! nuclear export GO:0051168 69 48 0,000 0,1067217 0,11956158 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,1067217 0,11950337 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,1067217 0,11944521 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,10882245 0,12173717 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,10882245 0,12167799 ! sensory perception of smell GO:0007608 61 49 0,000 0,10882245 0,12161887 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,10882245 0,1215598 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,10882245 0,12150079 ! RNA elongation GO:0006354 62 49 0,000 0,10882245 0,12144184 ! germ cell development GO:0007281 68 49 0,000 0,10882245 0,12138294 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,10882245 0,12132411 ! cartilage development GO:0051216 70 49 0,000 0,10882245 0,12126532 ! maintenance of location GO:0051235 84 49 0,000 0,10882245 0,1212066 ! regulation of actin filament length GO:0030832 72 50 0,000 0,11091837 0,12348125 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,11091837 0,12342151 ! positive regulation of growth GO:0045927 67 50 0,000 0,11091837 0,12336183 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,11091837 0,1233022 ! proton transport GO:0015992 75 50 0,000 0,11091837 0,12324264 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,11091837 0,12318313 ! hydrogen transport GO:0006818 77 51 0,000 0,11300949 0,1254449 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,11300949 0,12538438 ! adult behavior GO:0030534 80 51 0,000 0,11300949 0,12532393 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,11300949 0,12526353 ! transition metal ion transport GO:0000041 74 52 0,000 0,11509581 0,12751462 ! regulation of cellular component size GO:0032535 74 52 0,000 0,11509581 0,12745323 ! aging GO:0007568 79 52 0,000 0,11509581 0,1273919 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,11509581 0,12733062 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,11509581 0,1272694 ! establishment of organelle localization GO:0051656 85 52 0,000 0,11509581 0,12720825 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,11717734 0,12944663 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,11717734 0,12938448 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,11717734 0,1293224 ! single fertilization GO:0007338 59 53 0,000 0,11717734 0,12926037 ! cell projection assembly GO:0030031 76 53 0,000 0,11717734 0,12919841 ! amino acid transport GO:0006865 84 54 0,000 0,11925409 0,13142521 ! regulation of mitosis GO:0007088 84 54 0,000 0,11925409 0,13136227 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,11925409 0,13129938 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,11925409 0,13123656 ! DNA catabolic process GO:0006308 67 54 0,000 0,11925409 0,1311738 ! detection of external stimulus GO:0009581 66 54 0,000 0,11925409 0,1311111 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,11925409 0,13104845 ! exocytosis GO:0006887 74 55 0,000 0,12132608 0,13326169 ! mesoderm development GO:0007498 76 55 0,000 0,12132608 0,13319808 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,12132608 0,13313453 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,12132608 0,13307104 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,12339331 0,13527389 ! carbohydrate transport GO:0008643 74 57 0,000 0,12545579 0,13746943 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,12545579 0,13740397 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,12545579 0,13733857 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,12545579 0,13727323 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,12545579 0,13720795 ! camera-type eye development GO:0043010 88 57 0,000 0,12545579 0,13714274 ! secondary metabolic process GO:0019748 84 57 0,000 0,12545579 0,13707759 ! gonad development GO:0008406 79 57 0,000 0,12545579 0,1370125 ! viral reproductive process GO:0022415 87 58 0,000 0,12751355 0,13919371 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,12751355 0,13912768 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,12751355 0,13906171 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,12956657 0,14123371 ! activation of MAPK activity GO:0000187 84 59 0,000 0,12956657 0,1411668 ! lung development GO:0030324 94 59 0,000 0,12956657 0,14109996 ! actin filament organization GO:0007015 95 59 0,000 0,12956657 0,14103318 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,12956657 0,14096647 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,12956657 0,14089982 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,13161489 0,14305966 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,13161489 0,14299208 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,13161489 0,14292457 ! regulation of heart contraction GO:0008016 91 60 0,000 0,13161489 0,14285712 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,13161489 0,14278974 ! fertilization GO:0009566 68 60 0,000 0,13161489 0,14272241 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,13161489 0,14265516 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,1336585 0,14480195 ! meiosis GO:0007126 96 61 0,000 0,1336585 0,14473378 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,1336585 0,14466567 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,1336585 0,14459762 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,1336585 0,14452964 ! extracellular matrix organization GO:0030198 103 61 0,000 0,1336585 0,14446172 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,1336585 0,14439387 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,1336585 0,14432608 ! amine catabolic process GO:0009310 90 62 0,000 0,13569742 0,14645897 ! neurotransmitter transport GO:0006836 81 62 0,000 0,13569742 0,14639027 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,13569742 0,14632164 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,13569742 0,14625307 ! respiratory tube development GO:0030323 99 62 0,000 0,13569742 0,14618457 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,13569742 0,14611613 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,13569742 0,14604776 ! meiotic cell cycle GO:0051321 97 62 0,000 0,13569742 0,14597945 ! organelle localization GO:0051640 96 62 0,000 0,13569742 0,1459112 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,13773165 0,14802935 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,13773165 0,14796021 ! viral reproduction GO:0016032 92 63 0,000 0,13773165 0,14789113 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,13976122 0,15000037 ! negative regulation of cell size GO:0045792 108 64 0,000 0,13976122 0,14993041 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,13976122 0,14986051 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,13976122 0,14979068 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,13976122 0,14972091 ! hexose catabolic process GO:0019320 82 64 0,000 0,13976122 0,14965121 ! respiratory system development GO:0060541 100 64 0,000 0,13976122 0,14958157 ! adaptive immune response GO:0002250 94 64 0,000 0,13976122 0,149512 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,14178612 0,15160766 ! B cell activation GO:0042113 104 65 0,000 0,14178612 0,15153721 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,14178612 0,15146683 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,14178612 0,15139651 ! defense response to bacterium GO:0042742 73 65 0,000 0,14178612 0,15132626 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,14178612 0,15125607 ! activation of immune response GO:0002253 83 65 0,000 0,14178612 0,15118595 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,14380638 0,15326908 ! antigen processing and presentation GO:0019882 96 66 0,000 0,14380638 0,15319809 ! axon guidance GO:0007411 99 66 0,000 0,14380638 0,15312716 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,14380638 0,1530563 ! regulation of immune effector process GO:0002697 101 66 0,000 0,14380638 0,15298551 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,14582199 0,15505806 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,14582199 0,15498641 ! acute inflammatory response GO:0002526 92 68 0,000 0,14783298 0,1570512 ! learning or memory GO:0007611 123 68 0,000 0,14783298 0,15697869 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,14783298 0,15690625 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,14783298 0,15683388 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,14783298 0,15676157 ! rhythmic process GO:0048511 105 68 0,000 0,14783298 0,15668933 ! inorganic anion transport GO:0015698 93 68 0,000 0,14783298 0,15661716 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,14983934 0,15866965 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,14983934 0,15859663 ! response to drug GO:0042493 108 69 0,000 0,14983934 0,15852368 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,14983934 0,1584508 ! response to metal ion GO:0010038 103 70 0,000 0,1518411 0,16049381 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,1518411 0,16042009 ! humoral immune response GO:0006959 86 70 0,000 0,1518411 0,16034643 ! eye development GO:0001654 111 70 0,000 0,1518411 0,16027284 ! amine transport GO:0015837 101 70 0,000 0,1518411 0,16019932 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,1518411 0,16012587 ! regulation of catabolic process GO:0009894 106 70 0,000 0,1518411 0,16005249 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,15383826 0,16208337 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,15383826 0,16200915 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,15383826 0,16193501 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,15383826 0,16186093 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,15383826 0,16178692 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,15383826 0,16171298 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,15583083 0,16373271 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,15583083 0,16365795 ! negative regulation of transport GO:0051051 116 73 0,000 0,15781882 0,16567014 ! regulation of blood pressure GO:0008217 107 73 0,000 0,15781882 0,16559456 ! mitochondrion organization GO:0007005 104 73 0,000 0,15781882 0,16551905 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,15781882 0,16544361 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,15781882 0,16536824 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,15980224 0,16737029 ! digestion GO:0007586 97 74 0,000 0,15980224 0,16729411 ! protein import into nucleus GO:0006606 118 74 0,000 0,15980224 0,167218 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,15980224 0,16714195 ! blood coagulation GO:0007596 116 75 0,000 0,16178111 0,1691348 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,16178111 0,16905795 ! negative regulation of growth GO:0045926 123 75 0,000 0,16178111 0,16898118 ! response to nutrient GO:0007584 104 75 0,000 0,16178111 0,16890447 ! regulation of ligase activity GO:0051340 114 75 0,000 0,16178111 0,16882784 ! nuclear import GO:0051170 121 75 0,000 0,16178111 0,16875127 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,16178111 0,16867477 ! amine biosynthetic process GO:0009309 97 76 0,000 0,16375543 0,17065586 ! tRNA metabolic process GO:0006399 95 76 0,000 0,16375543 0,17057857 ! response to unfolded protein GO:0006986 99 76 0,000 0,16375543 0,17050135 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,16375543 0,1704242 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,16572521 0,17239619 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,16572521 0,17231826 ! regulation of DNA binding GO:0051101 119 77 0,000 0,16572521 0,17224039 ! sex differentiation GO:0007548 105 77 0,000 0,16572521 0,17216259 ! protein ubiquitination GO:0016567 125 77 0,000 0,16572521 0,17208487 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,16572521 0,17200721 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,16572521 0,17192963 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,16572521 0,17185211 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,16769047 0,17381166 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,16769047 0,17373336 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,16769047 0,17365514 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,1696512 0,17560656 ! cellular respiration GO:0045333 107 79 0,000 0,1696512 0,17552756 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,1696512 0,17544864 ! T cell activation GO:0042110 134 79 0,000 0,1696512 0,17536978 ! regulation of lyase activity GO:0051339 133 79 0,000 0,1696512 0,175291 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,1696512 0,17521229 ! chromatin assembly GO:0031497 102 80 0,000 0,17160744 0,1771531 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,17160744 0,17707362 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,17160744 0,17699422 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,17160744 0,17691488 ! forebrain development GO:0030900 131 80 0,000 0,17160744 0,17683562 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,17355917 0,17876672 ! hemostasis GO:0007599 125 81 0,000 0,17355917 0,1786867 ! mRNA transport GO:0051028 121 81 0,000 0,17355917 0,17860675 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,17355917 0,17852687 ! response to protein stimulus GO:0051789 111 81 0,000 0,17355917 0,17844707 ! regulation of neurological system process GO:0031644 122 81 0,000 0,17355917 0,17836733 ! vitamin metabolic process GO:0006766 103 81 0,000 0,17355917 0,17828767 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,17355917 0,17820808 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 0,000 0,17550642 0,18012707 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,17744919 0,18203976 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,17744919 0,1819586 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,17744919 0,18187751 ! regulation of defense response GO:0031347 117 84 0,000 0,1793875 0,18378229 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,1793875 0,18370046 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,1793875 0,18361871 ! sterol metabolic process GO:0016125 120 84 0,000 0,1793875 0,18353703 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,18132135 0,18543312 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,18132135 0,18535071 ! rRNA metabolic process GO:0016072 107 85 0,000 0,18132135 0,18526837 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,18132135 0,1851861 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,18132135 0,1851039 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,18325075 0,18699056 ! nucleosome organization GO:0034728 114 87 0,000 0,18517572 0,18887102 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,18517572 0,1887873 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,18517572 0,18870365 ! female pregnancy GO:0007565 130 87 0,000 0,18517572 0,18862008 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,18709626 0,19049198 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,18709626 0,19040769 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,18709626 0,19032348 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,18709626 0,19023934 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,18709626 0,19015528 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,18901238 0,19201788 ! reproductive developmental process GO:0003006 127 89 0,000 0,18901238 0,1919331 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,18901238 0,1918484 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,18901238 0,19176377 ! regulation of T cell activation GO:0050863 128 89 0,000 0,18901238 0,19167922 ! leukocyte differentiation GO:0002521 143 90 0,000 0,1909241 0,19353258 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,1909241 0,19344732 ! hormone metabolic process GO:0042445 121 90 0,000 0,1909241 0,19336214 ! RNA localization GO:0006403 135 91 0,000 0,19283142 0,19520786 ! ATP metabolic process GO:0046034 137 91 0,000 0,19283142 0,19512198 ! response to virus GO:0009615 122 91 0,000 0,19283142 0,19503617 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,19473435 0,19687429 ! positive regulation of immune response GO:0050778 121 92 0,000 0,19473435 0,19678779 ! DNA recombination GO:0006310 146 92 0,000 0,19473435 0,19670136 ! sulfur metabolic process GO:0006790 118 92 0,000 0,19473435 0,19661502 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,19663291 0,19844479 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,19663291 0,19835776 ! electron transport chain GO:0022900 123 94 0,000 0,1985271 0,20018076 ! response to oxidative stress GO:0006979 141 94 0,000 0,1985271 0,20009304 ! regulation of binding GO:0051098 151 95 0,000 0,20041693 0,2019093 ! angiogenesis GO:0001525 149 95 0,000 0,20041693 0,2018209 ! carboxylic acid transport GO:0046942 147 95 0,000 0,20041693 0,20173257 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,20230241 0,20354136 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,20230241 0,20345236 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,20230241 0,20336344 ! protein maturation GO:0051604 129 96 0,000 0,20230241 0,20327459 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,20418356 0,20507519 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,20418356 0,20498567 ! extracellular structure organization GO:0043062 156 99 0,000 0,20793287 0,20865864 ! protein import GO:0017038 156 99 0,000 0,20793287 0,20856764 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,20793287 0,20847673 ! regulation of translation GO:0006417 151 100 0,000 0,20980106 0,21025815 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,20980106 0,21016657 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,20980106 0,21007507 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,20980106 0,20998366 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,20980106 0,20989232 ! protein localization in organelle GO:0033365 161 100 0,000 0,20980106 0,20980106