pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/678-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,825E-05 0,0419786 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 2,143E-05 0,02464568 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 3,776E-05 0,02894696 ! positive regulation of vasoconstriction GO:0045907 9 5 1,000 7,343E-05 0,04222427 ! negative regulation of T cell mediated immunity GO:0002710 11 5 1,000 7,343E-05 0,03377942 GO:0002707|negative regulation of lymphocyte mediated immunity, ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 1,000 7,343E-05 0,02814952 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 1,000 7,343E-05 0,02412816 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 1,000 7,343E-05 0,02111214 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 7,343E-05 0,01876634 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 8,603E-05 0,01978746 ! thymic T cell selection GO:0045061 12 6 1,000 1,1E-04 0,02299104 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 1,1E-04 0,02107512 ! gas homeostasis GO:0033483 11 6 1,000 1,1E-04 0,01945395 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 1,1E-04 0,01806439 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 1,1E-04 0,01686009 ! protein homooligomerization GO:0051260 52 35 2,000 1,195E-04 0,01718266 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,537E-04 0,02079066 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 1,537E-04 0,01963563 ! positive regulation of isotype switching GO:0045830 15 7 1,000 1,537E-04 0,01860217 GO:0045911|positive regulation of DNA recombination, ! vesicle fusion GO:0006906 15 7 1,000 1,537E-04 0,01767206 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 1,000 1,537E-04 0,01683054 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 1,000 1,537E-04 0,01606551 ! B cell receptor signaling pathway GO:0050853 11 7 1,000 1,537E-04 0,01536701 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 1,000 1,537E-04 0,01472672 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 1,656E-04 0,01523742 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,045E-04 0,01809342 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 2,045E-04 0,0174233 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 2,045E-04 0,01680103 ! induction of an organ GO:0001759 11 8 1,000 2,045E-04 0,01622169 ! positive regulation of cell cycle GO:0045787 77 45 2,000 2,542E-04 0,0194892 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 2,625E-04 0,01947669 ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 2,625E-04 0,01886804 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 2,625E-04 0,01829628 GO:0010469|regulation of receptor activity, ! T cell selection GO:0045058 18 9 1,000 2,625E-04 0,01775815 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 1,000 2,625E-04 0,01725078 GO:0002820|negative regulation of adaptive immune response, ! positive regulation of protein polymerization GO:0032273 15 9 1,000 2,625E-04 0,01677159 ! localization within membrane GO:0051668 15 9 1,000 2,625E-04 0,0163183 ! regulation of B cell proliferation GO:0030888 15 10 1,000 3,276E-04 0,01982629 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 3,276E-04 0,01931793 ! regulation of B cell differentiation GO:0045577 16 10 1,000 3,276E-04 0,01883498 ! mRNA polyadenylation GO:0006378 18 10 1,000 3,276E-04 0,01837559 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 3,276E-04 0,01793808 ! developmental induction GO:0031128 13 10 1,000 3,276E-04 0,01752091 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 1,000 3,276E-04 0,01712271 ! negative regulation of immune effector process GO:0002698 16 10 1,000 3,276E-04 0,0167422 ! positive regulation of organelle organization GO:0010638 82 51 2,000 3,688E-04 0,01843923 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 3,997E-04 0,01955762 ! RNA polyadenylation GO:0043631 19 11 1,000 3,997E-04 0,01915017 ! T cell proliferation GO:0042098 20 11 1,000 3,997E-04 0,01875935 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 3,997E-04 0,01838416 ! regulation of isotype switching GO:0045191 19 11 1,000 3,997E-04 0,01802369 ! mRNA 3'-end processing GO:0031124 19 11 1,000 3,997E-04 0,01767708 ! gland morphogenesis GO:0022612 23 12 1,000 4,787E-04 0,0207758 ! RNA 3'-end processing GO:0031123 20 12 1,000 4,787E-04 0,02039107 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 5,122E-04 0,02141966 ! negative regulation of kinase activity GO:0033673 100 58 2,000 5,391E-04 0,02214201 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 5,648E-04 0,02279021 ! lipid localization GO:0010876 24 13 1,000 5,648E-04 0,02239727 GO:0019915|lipid storage, ! organelle fusion GO:0048284 28 13 1,000 5,648E-04 0,02201766 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 5,648E-04 0,0216507 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 5,648E-04 0,02129577 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 5,648E-04 0,02095229 ! activation of MAPK activity GO:0000187 84 59 2,000 5,669E-04 0,02069632 ! negative regulation of transferase activity GO:0051348 105 61 2,000 6,252E-04 0,02246783 ! regulation of S phase GO:0033261 18 14 1,000 6,578E-04 0,02327531 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 6,578E-04 0,02292265 ! heterophilic cell adhesion GO:0007157 29 14 1,000 6,578E-04 0,02258052 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 6,578E-04 0,02224846 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 6,578E-04 0,02192601 GO:0060675|ureteric bud morphogenesis, ! positive regulation of axonogenesis GO:0050772 19 14 1,000 6,578E-04 0,02161279 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 6,578E-04 0,02130838 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 6,872E-04 0,02195166 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 7,53E-04 0,02372349 ! protein oligomerization GO:0051259 100 65 2,000 7,53E-04 0,02340291 ! lipid phosphorylation GO:0046834 23 15 1,000 7,576E-04 0,02323456 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 7,576E-04 0,02292884 ! DNA integration GO:0015074 22 15 1,000 7,576E-04 0,02263107 ! regulation of vasodilation GO:0042312 24 15 1,000 7,576E-04 0,02234092 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 7,576E-04 0,02205813 ! defense response to virus GO:0051607 27 15 1,000 7,576E-04 0,0217824 ! negative regulation of immune response GO:0050777 28 16 1,000 8,644E-04 0,0245438 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 1,000 8,644E-04 0,02424449 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 8,644E-04 0,02395238 ! positive regulation of cell killing GO:0031343 24 17 1,000 9,779E-04 0,02677593 ! inactivation of MAPK activity GO:0000188 27 17 1,000 9,779E-04 0,02646092 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 9,779E-04 0,02615323 ! synaptogenesis GO:0007416 24 17 1,000 9,779E-04 0,02585262 ! regulation of immunoglobulin production GO:0002637 25 17 1,000 9,779E-04 0,02555884 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 9,779E-04 0,02527166 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 1,000 9,779E-04 0,02499087 GO:0002712|regulation of B cell mediated immunity, ! regulation of peptidase activity GO:0052547 106 72 2,000 1,014E-03 0,0256373 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 1,098E-03 0,02745541 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 1,098E-03 0,02716019 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 1,225E-03 0,02998004 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,225E-03 0,02966446 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 1,225E-03 0,02935546 ! regulation of ARF GTPase activity GO:0032312 31 20 1,000 1,359E-03 0,03222445 ! positive regulation of B cell activation GO:0050871 31 20 1,000 1,359E-03 0,03189563 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 1,000 1,359E-03 0,03157345 ! regulation of cell cycle process GO:0010564 122 81 2,000 1,426E-03 0,03280348 ! regulation of cell killing GO:0031341 34 21 1,000 1,499E-03 0,03414613 ! vesicle docking GO:0048278 27 21 1,000 1,499E-03 0,03381136 ! regulation of DNA recombination GO:0000018 40 21 1,000 1,499E-03 0,03348309 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 1,499E-03 0,03316114 ! regulation of vasoconstriction GO:0019229 31 21 1,000 1,499E-03 0,03284532 ! immunoglobulin production GO:0002377 33 21 1,000 1,499E-03 0,03253546 GO:0002440|production of molecular mediator of immune response, ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 1,499E-03 0,03223139 ! leukocyte adhesion GO:0007159 38 22 1,000 1,647E-03 0,03506483 ! vasculogenesis GO:0001570 33 22 1,000 1,647E-03 0,03474313 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 1,647E-03 0,03442729 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 1,647E-03 0,03411713 ! ureteric bud development GO:0001657 32 22 1,000 1,647E-03 0,03381251 ! membrane depolarization GO:0051899 35 22 1,000 1,647E-03 0,03351329 ! regulation of blood coagulation GO:0030193 34 22 1,000 1,647E-03 0,03321931 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 1,8E-03 0,03600363 ! lymphocyte proliferation GO:0046651 36 23 1,000 1,8E-03 0,03569326 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 1,8E-03 0,03538818 ! positive regulation of cell projection organization GO:0031346 39 24 1,000 1,96E-03 0,03821123 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 1,96E-03 0,03789012 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 1,96E-03 0,03757437 ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 1,96E-03 0,03726384 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 1,96E-03 0,0369584 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 1,96E-03 0,03665792 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 2,127E-03 0,03945516 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 2,127E-03 0,03913952 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 2,127E-03 0,03882889 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 2,127E-03 0,03852315 ! positive regulation of nuclear division GO:0051785 39 25 1,000 2,127E-03 0,03822219 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 1,000 2,127E-03 0,03792589 GO:0032943|mononuclear cell proliferation, ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 2,3E-03 0,0406991 ! negative regulation of protein modification process GO:0031400 50 26 1,000 2,3E-03 0,04038842 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 2,3E-03 0,04008245 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 2,3E-03 0,03978108 ! regulation of coagulation GO:0050818 39 26 1,000 2,3E-03 0,0394842 ! membrane docking GO:0022406 39 27 1,000 2,48E-03 0,04225313 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 2,48E-03 0,04194244 ! calcium ion transport GO:0006816 167 99 2,000 2,533E-03 0,04252407 ! extracellular structure organization GO:0043062 156 99 2,000 2,533E-03 0,04221592 ! homophilic cell adhesion GO:0007156 149 100 2,000 2,606E-03 0,04312573 ! divalent metal ion transport GO:0070838 171 100 2,000 2,606E-03 0,04281769 ! cholesterol homeostasis GO:0042632 46 28 1,000 2,666E-03 0,04349096 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 1,000 2,666E-03 0,04318469 ! immune response-activating signal transduction GO:0002757 38 28 1,000 2,666E-03 0,0428827 GO:0002764|immune response-regulating signal transduction, ! positive regulation of T cell differentiation GO:0045582 39 28 1,000 2,666E-03 0,0425849 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 2,666E-03 0,04229121 ! regulation of B cell activation GO:0050864 42 28 1,000 2,666E-03 0,04200154 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 2,859E-03 0,04472764 ! regulation of axonogenesis GO:0050770 51 29 1,000 2,859E-03 0,04442542 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 2,859E-03 0,04412727 ! cholesterol transport GO:0030301 46 30 1,000 3,058E-03 0,04688202 GO:0015918|sterol transport, ! positive regulation of neurogenesis GO:0050769 45 30 1,000 3,058E-03 0,04657155 ! regulation of microtubule-based process GO:0032886 58 30 1,000 3,058E-03 0,04626515 ! positive regulation of immune effector process GO:0002699 40 30 1,000 3,058E-03 0,04596277 ! mammary gland development GO:0030879 57 31 1,000 3,263E-03 0,04872836 ! metanephros development GO:0001656 58 31 1,000 3,263E-03 0,04841398 ! cell fate specification GO:0001708 37 31 1,000 3,263E-03 0,04810364 ! regulation of ARF protein signal transduction GO:0032012 51 32 1,000 3,474E-03 0,05089475 ! neutral lipid metabolic process GO:0006638 41 32 1,000 3,474E-03 0,05057263 GO:0006639|acylglycerol metabolic process, ! calcium-mediated signaling GO:0019722 50 32 1,000 3,474E-03 0,05025456 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 3,474E-03 0,04994047 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 3,692E-03 0,05274004 ! positive regulation of cell development GO:0010720 54 33 1,000 3,692E-03 0,05241449 ! lipid homeostasis GO:0055088 55 33 1,000 3,692E-03 0,05209293 ! regulation of neuron projection development GO:0010975 63 34 1,000 3,916E-03 0,05491526 ! glycerol ether metabolic process GO:0006662 44 34 1,000 3,916E-03 0,05458245 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 3,916E-03 0,05425364 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 3,916E-03 0,05392876 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 4,146E-03 0,05675754 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 4,146E-03 0,05642169 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! organic ether metabolic process GO:0018904 46 36 1,000 4,382E-03 0,05928562 ! tissue remodeling GO:0048771 62 36 1,000 4,382E-03 0,05893892 ! regulation of T cell proliferation GO:0042129 58 38 1,000 4,873E-03 0,06515817 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 5,127E-03 0,06816421 ! cell growth GO:0016049 61 39 1,000 5,127E-03 0,06777246 ! synapse organization GO:0050808 55 39 1,000 5,127E-03 0,06738519 ! T cell differentiation GO:0030217 65 40 1,000 5,388E-03 0,07040585 ! positive regulation of protein transport GO:0051222 55 40 1,000 5,388E-03 0,07000807 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 5,654E-03 0,07305724 ! regulation of T cell differentiation GO:0045580 59 41 1,000 5,654E-03 0,07264909 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 5,926E-03 0,07572561 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 5,926E-03 0,07530724 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 5,926E-03 0,07489346 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 6,205E-03 0,07798151 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 6,205E-03 0,0775577 ! vesicle organization GO:0016050 79 43 1,000 6,205E-03 0,07713847 ! response to insulin stimulus GO:0032868 63 43 1,000 6,205E-03 0,07672375 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 6,205E-03 0,07631346 ! regulation of cell projection organization GO:0031344 83 44 1,000 6,489E-03 0,0793837 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 6,489E-03 0,07896368 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 6,779E-03 0,08205835 ! regulation of adaptive immune response GO:0002819 72 46 1,000 7,075E-03 0,08519056 ! response to UV GO:0009411 75 46 1,000 7,075E-03 0,08474686 ! negative regulation of immune system process GO:0002683 73 47 1,000 7,376E-03 0,0879015 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 7,376E-03 0,0874484 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of protein polymerization GO:0032271 71 47 1,000 7,376E-03 0,08699995 ! regulation of muscle contraction GO:0006937 69 48 1,000 7,683E-03 0,0901622 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 7,683E-03 0,08970453 ! regulation of intracellular transport GO:0032386 78 49 1,000 7,996E-03 0,09288751 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 7,996E-03 0,09242074 ! membrane fusion GO:0006944 80 50 1,000 8,315E-03 0,09562361 ! lipid modification GO:0030258 73 50 1,000 8,315E-03 0,09514787 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 8,639E-03 0,09836981 ! activation of phospholipase C activity GO:0007202 87 51 1,000 8,639E-03 0,09788523 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of cell migration GO:0030335 92 51 1,000 8,639E-03 0,0974054 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 8,969E-03 0,10063217 ! kidney development GO:0001822 90 53 1,000 9,305E-03 0,10388992 ! regulation of protein complex assembly GO:0043254 81 54 1,000 9,646E-03 0,10717787 ! regulation of mitosis GO:0007088 84 54 1,000 9,646E-03 0,10666259 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 9,646E-03 0,10615225 ! positive regulation of lipase activity GO:0060193 90 54 1,000 9,646E-03 0,10564676 ! mesoderm development GO:0007498 76 55 1,000 9,993E-03 0,1089242 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,0103447 0,11223025 ! negative regulation of response to stimulus GO:0048585 80 56 1,000 0,0103447 0,11170335 ! positive regulation of cell motion GO:0051272 99 56 1,000 0,0103447 0,11118137 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 0,01070225 0,11448915 ! lung development GO:0030324 94 59 1,000 0,01143358 0,12174643 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,0118073 0,12514651 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,0118073 0,12457245 ! urogenital system development GO:0001655 101 61 1,000 0,01218636 0,12798456 ! extracellular matrix organization GO:0030198 103 61 1,000 0,01218636 0,12740281 ! respiratory tube development GO:0030323 99 62 1,000 0,01257071 0,1308264 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01296033 0,13427374 ! respiratory system development GO:0060541 100 64 1,000 0,0133552 0,13774419 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01365478 0,14020532 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01365478 0,13958219 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01365478 0,13896457 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01365478 0,13835239 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01365478 0,13774558 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01365478 0,13714407 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01365478 0,13654779 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01365478 0,13595667 ! sleep GO:0030431 11 5 0,000 0,01365478 0,13537065 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01365478 0,13478966 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01365478 0,13421364 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01365478 0,13364252 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01365478 0,13307624 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01365478 0,13251473 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01365478 0,13195795 ! tongue development GO:0043586 6 5 0,000 0,01365478 0,13140582 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01365478 0,1308583 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01365478 0,13031532 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01365478 0,12977683 ! cobalt ion transport GO:0006824 9 5 0,000 0,01365478 0,12924276 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01365478 0,12871308 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01365478 0,12818772 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01365478 0,12766663 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01365478 0,12714976 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01365478 0,12663706 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01365478 0,12612848 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01365478 0,12562397 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01365478 0,12512347 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01365478 0,12462695 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01365478 0,12413436 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01365478 0,12364564 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01365478 0,12316075 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01365478 0,12267966 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01365478 0,1222023 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01365478 0,12172865 ! malate metabolic process GO:0006108 7 5 0,000 0,01365478 0,12125866 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01365478 0,12079228 ! behavioral response to pain GO:0048266 7 5 0,000 0,01365478 0,12032947 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01365478 0,1198702 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01365478 0,11941442 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01365478 0,11896209 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01365478 0,11851318 ! mating behavior GO:0007617 6 5 0,000 0,01365478 0,11806764 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01365478 0,11762544 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01365478 0,11718654 ! rhythmic behavior GO:0007622 12 5 0,000 0,01365478 0,1167509 ! copulation GO:0007620 7 5 0,000 0,01365478 0,11631849 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01365478 0,11588927 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01365478 0,11546321 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01365478 0,11504026 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01365478 0,11462041 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01365478 0,11420361 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01365478 0,11378983 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01365478 0,11337903 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01365478 0,11297119 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01365478 0,11256628 ! response to protozoan GO:0001562 9 5 0,000 0,01365478 0,11216426 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,01365478 0,1117651 ! lymph vessel development GO:0001945 7 5 0,000 0,01365478 0,11136877 ! endochondral ossification GO:0001958 12 5 0,000 0,01365478 0,11097524 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01365478 0,11058448 ! parathyroid gland development GO:0060017 8 5 0,000 0,01365478 0,11019646 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01365478 0,10981116 ! anagen GO:0042640 6 5 0,000 0,01365478 0,10942854 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01365478 0,10904858 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01365478 0,10867125 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01365478 0,10829652 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01365478 0,10792437 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01365478 0,10755477 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01365478 0,10718769 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01365478 0,1068231 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01365478 0,10646099 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01365478 0,10610132 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01365478 0,10574408 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01365478 0,10538923 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01365478 0,10503676 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01365478 0,10468664 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01365478 0,10433884 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01365478 0,10399335 ! ovulation GO:0030728 6 5 0,000 0,01365478 0,10365014 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01365478 0,10330918 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01365478 0,10297047 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01365478 0,10263396 ! response to pH GO:0009268 9 5 0,000 0,01365478 0,10229965 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01365478 0,10196751 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01365478 0,10163751 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01365478 0,10130965 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01365478 0,1009839 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01365478 0,10066023 ! polyol catabolic process GO:0046174 7 5 0,000 0,01365478 0,10033863 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01365478 0,10001908 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01365478 0,09970156 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01365478 0,09938605 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01365478 0,09907253 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01365478 0,09876098 ! urea metabolic process GO:0019627 6 5 0,000 0,01365478 0,09845139 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01365478 0,09814372 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01365478 0,09783798 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01365478 0,09753414 ! neutrophil activation GO:0042119 5 5 0,000 0,01365478 0,09723217 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01365478 0,09693207 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01365478 0,09663382 ! response to food GO:0032094 5 5 0,000 0,01365478 0,0963374 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01365478 0,09604279 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01365478 0,09574998 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01365478 0,09545894 ! forebrain neuron development GO:0021884 7 5 0,000 0,01365478 0,09516967 ! melanosome organization GO:0032438 7 5 0,000 0,01365478 0,09488215 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01365478 0,09459636 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01365478 0,09431229 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01365478 0,09402992 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01365478 0,09374923 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01365478 0,09347021 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01365478 0,09319285 ! nucleoside transport GO:0015858 6 5 0,000 0,01365478 0,09291714 ! nucleoside salvage GO:0043174 7 5 0,000 0,01365478 0,09264304 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01365478 0,09237056 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01365478 0,09209968 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01365478 0,09183039 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01365478 0,09156266 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01365478 0,09129649 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01365478 0,09103186 ! depyrimidination GO:0045008 8 5 0,000 0,01365478 0,09076876 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01365478 0,09050718 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01365478 0,0902471 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01365478 0,08998852 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01365478 0,08973141 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01365478 0,08947576 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01365478 0,08922157 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01365478 0,08896882 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01365478 0,08871749 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01365478 0,08846758 ! monocyte differentiation GO:0030224 8 5 0,000 0,01365478 0,08821908 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01365478 0,08797197 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01365478 0,08772623 ! centrosome duplication GO:0051298 5 5 0,000 0,01365478 0,08748187 ! response to UV-C GO:0010225 6 5 0,000 0,01365478 0,08723887 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01365478 0,08699721 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01365478 0,08675688 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01365478 0,08651788 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01365478 0,0862802 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01365478 0,08604381 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01365478 0,08580872 ! melanosome transport GO:0032402 8 5 0,000 0,01365478 0,08557491 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01365478 0,08534237 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01365478 0,08511109 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01365478 0,08488106 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01365478 0,08465227 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01365478 0,08442471 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01365478 0,08419837 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01365478 0,08397324 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01365478 0,08374931 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01365478 0,08352657 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01365478 0,08330502 ! neural tube patterning GO:0021532 6 5 0,000 0,01365478 0,08308463 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01365478 0,08286541 ! histone demethylation GO:0016577 9 5 0,000 0,01365478 0,08264735 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01365478 0,08243042 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01365478 0,08221464 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01365478 0,08199998 ! enteric nervous system development GO:0048484 8 5 0,000 0,01365478 0,08178644 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01365478 0,081574 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01365478 0,08136267 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01365478 0,08115243 ! transcription termination GO:0006353 8 5 0,000 0,01365478 0,08094328 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01365478 0,0807352 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01365478 0,08052818 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,01365478 0,08032223 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01365478 0,08011733 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01365478 0,07991347 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01365478 0,07971064 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01365478 0,07950884 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01365478 0,07930806 ! apical protein localization GO:0045176 6 5 0,000 0,01365478 0,07910829 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01365478 0,07890953 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01365478 0,07871176 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01365478 0,07851498 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01365478 0,07831918 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01365478 0,07812436 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01365478 0,0779305 ! glial cell migration GO:0008347 10 5 0,000 0,01365478 0,0777376 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01365478 0,07754566 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01365478 0,07735466 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01365478 0,0771646 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01365478 0,07697547 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01365478 0,07678727 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01365478 0,07659998 ! neural plate development GO:0001840 6 5 0,000 0,01365478 0,07641361 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01365478 0,07622814 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01365478 0,07604356 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01365478 0,07585988 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01365478 0,07567709 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01365478 0,07549517 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01365478 0,07531413 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01365478 0,07513395 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01365478 0,07495463 ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01365478 0,07477617 ! spindle assembly GO:0051225 5 5 0,000 0,01365478 0,07459856 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01365478 0,07442178 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01365478 0,07424584 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01365478 0,07407074 ! organ regeneration GO:0031100 7 5 0,000 0,01365478 0,07389645 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01365478 0,07372299 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01365478 0,07355033 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01365478 0,07337849 GO:0055081|anion homeostasis, ! regulation of caspase activity GO:0043281 97 65 1,000 0,01375527 0,07374619 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,01375527 0,07357469 ! activation of immune response GO:0002253 83 65 1,000 0,01375527 0,07340398 ! regulation of immune effector process GO:0002697 101 66 1,000 0,01416052 0,07539164 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,01457091 0,07739746 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,01457091 0,07721913 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,01457091 0,07704161 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,01498643 0,07905684 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,01498643 0,07887594 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,01583269 0,0831397 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,01626338 0,08520676 ! tRNA transcription GO:0009304 11 6 0,000 0,01636374 0,08553775 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01636374 0,08534379 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01636374 0,0851507 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01636374 0,08495849 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01636374 0,08476714 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01636374 0,08457665 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01636374 0,08438702 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01636374 0,08419823 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01636374 0,08401029 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01636374 0,08382318 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01636374 0,08363691 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01636374 0,08345146 ! prostate gland development GO:0030850 9 6 0,000 0,01636374 0,08326684 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01636374 0,08308302 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01636374 0,08290002 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01636374 0,08271782 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01636374 0,08253643 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01636374 0,08235582 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01636374 0,082176 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01636374 0,08199697 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01636374 0,08181872 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01636374 0,08164124 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01636374 0,08146452 ! neuron adhesion GO:0007158 9 6 0,000 0,01636374 0,08128857 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01636374 0,08111338 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01636374 0,08093895 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01636374 0,08076526 ! signal peptide processing GO:0006465 8 6 0,000 0,01636374 0,08059231 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01636374 0,08042011 ! mRNA stabilization GO:0048255 15 6 0,000 0,01636374 0,08024864 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01636374 0,08007789 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01636374 0,07990788 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01636374 0,07973858 ! opsonization GO:0008228 8 6 0,000 0,01636374 0,07957 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01636374 0,07940213 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01636374 0,07923497 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01636374 0,07906851 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01636374 0,07890275 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01636374 0,07873768 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01636374 0,0785733 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01636374 0,0784096 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01636374 0,07824659 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01636374 0,07808425 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01636374 0,07792259 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01636374 0,07776159 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01636374 0,07760126 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01636374 0,07744158 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01636374 0,07728257 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01636374 0,0771242 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01636374 0,07696648 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01636374 0,07680941 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01636374 0,07665297 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01636374 0,07649717 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01636374 0,07634201 ! protein lipoylation GO:0009249 10 6 0,000 0,01636374 0,07618747 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01636374 0,07603356 ! pigment granule organization GO:0048753 11 6 0,000 0,01636374 0,07588026 ! drug transport GO:0015893 6 6 0,000 0,01636374 0,07572759 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01636374 0,07557552 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01636374 0,07542407 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01636374 0,07527322 ! histidine metabolic process GO:0006547 6 6 0,000 0,01636374 0,07512297 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01636374 0,07497333 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01636374 0,07482427 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01636374 0,07467581 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01636374 0,07452794 ! adenohypophysis development GO:0021984 10 6 0,000 0,01636374 0,07438065 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01636374 0,07423394 ! hyperosmotic response GO:0006972 8 6 0,000 0,01636374 0,07408781 ! microtubule nucleation GO:0007020 10 6 0,000 0,01636374 0,07394226 ! ER overload response GO:0006983 7 6 0,000 0,01636374 0,07379727 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01636374 0,07365286 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01636374 0,073509 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01636374 0,07336571 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01636374 0,07322298 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01636374 0,0730808 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01636374 0,07293917 ! response to dietary excess GO:0002021 7 6 0,000 0,01636374 0,07279809 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01636374 0,07265755 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01636374 0,07251755 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01636374 0,0723781 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01636374 0,07223917 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01636374 0,07210079 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01636374 0,07196293 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01636374 0,07182559 ! neuron apoptosis GO:0051402 8 6 0,000 0,01636374 0,07168878 ! organic alcohol transport GO:0015850 9 6 0,000 0,01636374 0,07155249 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01636374 0,07141672 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01636374 0,07128146 ! male sex determination GO:0030238 9 6 0,000 0,01636374 0,07114671 ! carnitine transport GO:0015879 8 6 0,000 0,01636374 0,07101247 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01636374 0,07087874 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01636374 0,07074551 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01636374 0,07061278 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01636374 0,07048054 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01636374 0,0703488 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01636374 0,07021756 ! parturition GO:0007567 12 6 0,000 0,01636374 0,0700868 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01636374 0,06995652 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01636374 0,06982673 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01636374 0,06969743 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01636374 0,0695686 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01636374 0,06944024 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01636374 0,06931236 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01636374 0,06918494 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01636374 0,069058 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01636374 0,06893152 ! macrophage differentiation GO:0030225 10 6 0,000 0,01636374 0,0688055 ! astrocyte development GO:0014002 14 6 0,000 0,01636374 0,06867995 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01636374 0,06855485 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01636374 0,0684302 ! interaction with symbiont GO:0051702 8 6 0,000 0,01636374 0,06830601 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01636374 0,06818226 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01636374 0,06805897 ! eating behavior GO:0042755 6 6 0,000 0,01636374 0,06793612 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01636374 0,06781371 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01636374 0,06769174 ! response to copper ion GO:0046688 9 6 0,000 0,01636374 0,06757022 ! DNA topological change GO:0006265 8 6 0,000 0,01636374 0,06744912 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01636374 0,06732846 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01636374 0,06720823 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01636374 0,06708843 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01636374 0,06696906 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01636374 0,06685011 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01636374 0,06673158 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01636374 0,06661347 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01636374 0,06649578 ! hair follicle maturation GO:0048820 7 6 0,000 0,01636374 0,0663785 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01636374 0,06626164 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01636374 0,06614518 ! Schwann cell development GO:0014044 14 6 0,000 0,01636374 0,06602914 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01636374 0,0659135 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01636374 0,06579827 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01636374 0,06568344 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01636374 0,06556901 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01636374 0,06545497 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01636374 0,06534134 ! histone ubiquitination GO:0016574 7 6 0,000 0,01636374 0,06522809 ! regulation of meiosis GO:0040020 10 6 0,000 0,01636374 0,06511524 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01636374 0,06500278 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01636374 0,06489071 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01636374 0,06477902 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01636374 0,06466771 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01636374 0,06455679 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01636374 0,06444625 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01636374 0,06433609 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01636374 0,0642263 ! receptor internalization GO:0031623 9 6 0,000 0,01636374 0,06411688 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01636374 0,06400784 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01636374 0,06389917 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01636374 0,06379086 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01636374 0,06368293 ! protein deubiquitination GO:0016579 8 6 0,000 0,01636374 0,06357535 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01636374 0,06346814 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01636374 0,0633613 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01636374 0,06325481 ! axonal fasciculation GO:0007413 9 6 0,000 0,01636374 0,06314867 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01636374 0,0630429 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01636374 0,06293747 ! midbrain development GO:0030901 6 6 0,000 0,01636374 0,0628324 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01636374 0,06272768 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01636374 0,06262331 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01636374 0,06251929 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01636374 0,06241561 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01636374 0,06231227 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01636374 0,06220927 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01636374 0,06210662 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01636374 0,0620043 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01636374 0,06190232 ! adult feeding behavior GO:0008343 6 6 0,000 0,01636374 0,06180067 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01636374 0,06169936 ! blastocyst growth GO:0001832 15 6 0,000 0,01636374 0,06159838 ! pigment granule transport GO:0051904 12 6 0,000 0,01636374 0,06149773 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01636374 0,06139741 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01636374 0,06129741 ! catecholamine transport GO:0051937 7 6 0,000 0,01636374 0,06119774 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01636374 0,06109839 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01636374 0,06099937 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01636374 0,06090066 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01636374 0,06080228 ! protein prenylation GO:0018342 10 6 0,000 0,01636374 0,06070421 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01636374 0,06060646 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01636374 0,06050902 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01636374 0,06041189 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,01669906 0,06155104 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 1,000 0,01669906 0,06145256 ! tube morphogenesis GO:0035239 118 73 1,000 0,01713972 0,06297341 ! response to oxygen levels GO:0070482 137 74 1,000 0,01758532 0,06450754 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,01758532 0,06440482 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,01758532 0,06430243 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,01849121 0,06750759 ! regulation of protein transport GO:0051223 114 76 1,000 0,01849121 0,0674006 GO:0070201|regulation of establishment of protein localization, ! gland development GO:0048732 148 77 1,000 0,01895145 0,06896888 ! sex differentiation GO:0007548 105 77 1,000 0,01895145 0,06885992 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01906542 0,06916478 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01906542 0,06905586 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01906542 0,06894728 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01906542 0,06883904 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01906542 0,06873115 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01906542 0,06862359 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01906542 0,06851636 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01906542 0,06840947 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01906542 0,06830291 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01906542 0,06819669 ! reproductive behavior GO:0019098 12 7 0,000 0,01906542 0,06809079 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01906542 0,06798523 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,01906542 0,06787999 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01906542 0,06777507 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,01906542 0,06767048 ! oligopeptide transport GO:0006857 11 7 0,000 0,01906542 0,06756621 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01906542 0,06746226 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01906542 0,06735864 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,01906542 0,06725532 ! pericardium development GO:0060039 8 7 0,000 0,01906542 0,06715233 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01906542 0,06704965 ! fibril organization GO:0043206 13 7 0,000 0,01906542 0,06694728 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01906542 0,06684523 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01906542 0,06674349 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01906542 0,06664205 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01906542 0,06654093 ! lipoprotein transport GO:0042953 9 7 0,000 0,01906542 0,06644011 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01906542 0,06633959 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01906542 0,06623938 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01906542 0,06613947 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01906542 0,06603987 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01906542 0,06594056 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01906542 0,06584155 ! chemosensory behavior GO:0007635 9 7 0,000 0,01906542 0,06574284 ! microtubule bundle formation GO:0001578 8 7 0,000 0,01906542 0,06564442 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,01906542 0,0655463 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01906542 0,06544846 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01906542 0,06535093 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01906542 0,06525368 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01906542 0,06515672 ! reflex GO:0060004 12 7 0,000 0,01906542 0,06506005 ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01906542 0,06496366 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01906542 0,06486756 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01906542 0,06477175 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01906542 0,06467621 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01906542 0,06458096 ! spinal cord patterning GO:0021511 7 7 0,000 0,01906542 0,06448599 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01906542 0,06439129 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,01906542 0,06429688 ! adrenal gland development GO:0030325 17 7 0,000 0,01906542 0,06420274 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01906542 0,06410888 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01906542 0,06401529 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01906542 0,06392197 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01906542 0,06382892 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01906542 0,06373615 ! endosome organization GO:0007032 10 7 0,000 0,01906542 0,06364365 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01906542 0,06355141 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,01906542 0,06345944 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01906542 0,06336773 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01906542 0,06327629 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01906542 0,06318512 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01906542 0,0630942 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01906542 0,06300355 ! galactose metabolic process GO:0006012 10 7 0,000 0,01906542 0,06291316 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01906542 0,06282302 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01906542 0,06273315 ! organ growth GO:0035265 11 7 0,000 0,01906542 0,06264353 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,01906542 0,06255417 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,01906542 0,06246506 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01906542 0,0623762 ! retinol metabolic process GO:0042572 9 7 0,000 0,01906542 0,0622876 ! behavioral fear response GO:0001662 13 7 0,000 0,01906542 0,06219925 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,01906542 0,06211115 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01906542 0,0620233 ! rRNA modification GO:0000154 12 7 0,000 0,01906542 0,06193569 ! protein heterooligomerization GO:0051291 10 7 0,000 0,01906542 0,06184834 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01906542 0,06176123 ! response to UV-B GO:0010224 11 7 0,000 0,01906542 0,06167436 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01906542 0,06158774 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,01906542 0,06150136 ! intermediate filament organization GO:0045109 11 7 0,000 0,01906542 0,06141523 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,01906542 0,06132933 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01906542 0,06124368 ! fibrinolysis GO:0042730 9 7 0,000 0,01906542 0,06115826 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01906542 0,06107308 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01906542 0,06098814 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01906542 0,06090343 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01906542 0,06081896 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01906542 0,06073472 ! response to tropane GO:0014073 13 7 0,000 0,01906542 0,06065072 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01906542 0,06056695 ! melanosome localization GO:0032400 10 7 0,000 0,01906542 0,06048341 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01906542 0,0604001 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01906542 0,06031702 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,01906542 0,06023416 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01906542 0,06015154 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01906542 0,06006914 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01906542 0,05998696 ! mast cell activation GO:0045576 9 7 0,000 0,01906542 0,05990502 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01906542 0,05982329 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,01906542 0,05974179 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01906542 0,05966051 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01906542 0,05957944 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01906542 0,0594986 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01906542 0,05941798 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,01906542 0,05933758 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01906542 0,05925739 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01906542 0,05917742 ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01906542 0,05909767 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01906542 0,05901813 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01906542 0,05893881 ! response to tumor cell GO:0002347 12 7 0,000 0,01906542 0,05885969 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01906542 0,05878079 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01906542 0,0587021 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01906542 0,05862362 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,01906542 0,05854536 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01906542 0,0584673 ! diuresis GO:0030146 12 7 0,000 0,01906542 0,05838944 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01906542 0,0583118 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01906542 0,05823436 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01906542 0,05815712 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01906542 0,05808009 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01906542 0,05800327 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01906542 0,05792665 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01906542 0,05785023 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01906542 0,05777401 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01906542 0,05769799 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01906542 0,05762217 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01906542 0,05754655 ! lymph node development GO:0048535 9 7 0,000 0,01906542 0,05747113 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01906542 0,0573959 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01906542 0,05732088 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01906542 0,05724605 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,01906542 0,05717141 ! ATP catabolic process GO:0006200 10 7 0,000 0,01906542 0,05709697 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01906542 0,05702272 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01906542 0,05694866 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,01906542 0,0568748 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01906542 0,05680113 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01906542 0,05672765 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01906542 0,05665436 ! muscle adaptation GO:0043500 12 7 0,000 0,01906542 0,05658125 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01906542 0,05650834 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01906542 0,05643561 ! retina homeostasis GO:0001895 9 7 0,000 0,01906542 0,05636307 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01906542 0,05629072 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01906542 0,05621855 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01906542 0,05614657 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01906542 0,05607477 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01906542 0,05600316 ! T cell activation GO:0042110 134 79 1,000 0,01988637 0,05834011 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,02036099 0,05965641 ! forebrain development GO:0030900 131 80 1,000 0,02036099 0,05958051 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,02084035 0,06090573 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,02132442 0,06224134 GO:0060348|bone development, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02175983 0,06343171 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02175983 0,06335142 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,02175983 0,06327133 ! axon extension GO:0048675 11 8 0,000 0,02175983 0,06319144 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02175983 0,06311175 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02175983 0,06303227 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02175983 0,06295298 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02175983 0,06287389 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02175983 0,06279501 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02175983 0,06271632 ! phosphate transport GO:0006817 10 8 0,000 0,02175983 0,06263782 ! N-glycan processing GO:0006491 12 8 0,000 0,02175983 0,06255953 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02175983 0,06248142 ! UTP metabolic process GO:0046051 8 8 0,000 0,02175983 0,06240352 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02175983 0,0623258 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02175983 0,06224828 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,02175983 0,06217096 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02175983 0,06209382 ! succinate metabolic process GO:0006105 14 8 0,000 0,02175983 0,06201688 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,02175983 0,06194012 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02175983 0,06186356 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02175983 0,06178719 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02175983 0,061711 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,02175983 0,061635 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02175983 0,06155919 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02175983 0,06148356 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02175983 0,06140812 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02175983 0,06133287 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02175983 0,0612578 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,02175983 0,06118291 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02175983 0,06110821 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02175983 0,06103368 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02175983 0,06095934 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02175983 0,06088518 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02175983 0,0608112 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,02175983 0,0607374 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02175983 0,06066378 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02175983 0,06059034 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02175983 0,06051707 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02175983 0,06044399 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02175983 0,06037107 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02175983 0,06029834 ! melanin metabolic process GO:0006582 12 8 0,000 0,02175983 0,06022578 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02175983 0,06015339 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02175983 0,06008118 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,02175983 0,06000914 ! macrophage activation GO:0042116 12 8 0,000 0,02175983 0,05993727 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02175983 0,05986557 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02175983 0,05979405 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,02175983 0,0597227 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02175983 0,05965151 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02175983 0,0595805 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02175983 0,05950966 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02175983 0,05943898 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02175983 0,05936847 ! ruffle organization GO:0031529 11 8 0,000 0,02175983 0,05929813 ! osteoblast development GO:0002076 13 8 0,000 0,02175983 0,05922795 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02175983 0,05915794 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02175983 0,0590881 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02175983 0,05901842 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02175983 0,0589489 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02175983 0,05887955 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02175983 0,05881036 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02175983 0,05874134 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02175983 0,05867247 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02175983 0,05860377 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02175983 0,05853523 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02175983 0,05846685 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02175983 0,05839862 ! segment specification GO:0007379 10 8 0,000 0,02175983 0,05833056 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02175983 0,05826265 ! cellular extravasation GO:0045123 11 8 0,000 0,02175983 0,05819491 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02175983 0,05812732 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02175983 0,05805988 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02175983 0,05799261 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,02175983 0,05792549 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02175983 0,05785852 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02175983 0,05779171 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,02175983 0,05772505 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02175983 0,05765855 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02175983 0,0575922 ! nucleosome disassembly GO:0006337 12 8 0,000 0,02175983 0,057526 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02175983 0,05745995 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02175983 0,05739406 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02175983 0,05732832 ! icosanoid secretion GO:0032309 12 8 0,000 0,02175983 0,05726272 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02175983 0,05719728 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02175983 0,05713199 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02175983 0,05706684 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02175983 0,05700185 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02175983 0,056937 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02175983 0,0568723 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02175983 0,05680774 ! sterol catabolic process GO:0016127 9 8 0,000 0,02175983 0,05674333 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02175983 0,05667907 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02175983 0,05661496 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02175983 0,05655098 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02175983 0,05648716 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02175983 0,05642347 ! prophase GO:0051324 11 8 0,000 0,02175983 0,05635993 ! S phase GO:0051320 8 8 0,000 0,02175983 0,05629654 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02175983 0,05623328 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02175983 0,05617017 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02175983 0,0561072 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02175983 0,05604437 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02175983 0,05598168 ! hormone catabolic process GO:0042447 13 8 0,000 0,02175983 0,05591913 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02175983 0,05585672 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02175983 0,05579445 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02175983 0,05573232 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02175983 0,05567032 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02175983 0,05560847 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02175983 0,05554675 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02175983 0,05548517 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02175983 0,05542372 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02175983 0,05536241 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02175983 0,05530124 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02175983 0,0552402 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02175983 0,05517929 ! regulation of embryonic development GO:0045995 16 8 0,000 0,02175983 0,05511852 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02175983 0,05505789 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02175983 0,05499738 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,02175983 0,05493701 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,0228046 0,05751161 ! regulation of protein localization GO:0032880 132 85 1,000 0,0228046 0,05744862 ! regulation of membrane potential GO:0042391 128 85 1,000 0,0228046 0,05738576 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,0228046 0,05732305 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,02330723 0,05852251 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,02381442 0,05973082 GO:0060538|skeletal muscle organ development, ! interphase GO:0051325 159 88 1,000 0,02432615 0,06094788 ! regulation of developmental growth GO:0048638 13 9 0,000 0,024447 0,06118401 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,024447 0,0611175 ! telencephalon cell migration GO:0022029 16 9 0,000 0,024447 0,06105114 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,024447 0,06098492 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,024447 0,06091885 ! CTP metabolic process GO:0046036 9 9 0,000 0,024447 0,06085292 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,024447 0,06078714 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,024447 0,06072149 ! GTP metabolic process GO:0046039 9 9 0,000 0,024447 0,06065599 ! elastic fiber assembly GO:0048251 13 9 0,000 0,024447 0,06059063 ! social behavior GO:0035176 14 9 0,000 0,024447 0,0605254 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,024447 0,06046032 ! artery development GO:0060840 19 9 0,000 0,024447 0,06039538 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,024447 0,06033058 ! regulation of glycolysis GO:0006110 15 9 0,000 0,024447 0,06026592 ! response to pain GO:0048265 16 9 0,000 0,024447 0,06020139 ! protein complex disassembly GO:0043241 17 9 0,000 0,024447 0,06013701 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,024447 0,06007276 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,024447 0,06000865 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,024447 0,05994467 ! lung alveolus development GO:0048286 17 9 0,000 0,024447 0,05988083 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,024447 0,05981713 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,024447 0,05975356 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,024447 0,05969013 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,024447 0,05962683 ! ventral spinal cord development GO:0021517 11 9 0,000 0,024447 0,05956367 ! protein targeting to ER GO:0045047 19 9 0,000 0,024447 0,05950064 ! endoderm development GO:0007492 12 9 0,000 0,024447 0,05943774 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,024447 0,05937497 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,024447 0,05931234 ! arginine catabolic process GO:0006527 10 9 0,000 0,024447 0,05924984 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,024447 0,05918747 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,024447 0,05912524 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,024447 0,05906313 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,024447 0,05900116 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,024447 0,05893931 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,024447 0,05887759 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,024447 0,058816 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,024447 0,05875455 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,024447 0,05869322 ! mannose metabolic process GO:0006013 9 9 0,000 0,024447 0,05863201 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,024447 0,05857094 ! receptor clustering GO:0043113 15 9 0,000 0,024447 0,05850999 ! epithelial cell development GO:0002064 10 9 0,000 0,024447 0,05844917 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,024447 0,05838847 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,024447 0,05832791 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,024447 0,05826746 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,024447 0,05820714 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,024447 0,05814695 ! motor axon guidance GO:0008045 14 9 0,000 0,024447 0,05808688 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,024447 0,05802694 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,024447 0,05796711 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,024447 0,05790742 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,024447 0,05784784 ! blastoderm segmentation GO:0007350 11 9 0,000 0,024447 0,05778839 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,024447 0,05772906 ! DNA ligation GO:0006266 14 9 0,000 0,024447 0,05766985 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,024447 0,05761076 ! response to amine stimulus GO:0014075 13 9 0,000 0,024447 0,05755179 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,024447 0,05749295 ! erythrocyte development GO:0048821 11 9 0,000 0,024447 0,05743422 ! renal water homeostasis GO:0003091 14 9 0,000 0,024447 0,05737561 ! postreplication repair GO:0006301 11 9 0,000 0,024447 0,05731713 ! mRNA cleavage GO:0006379 13 9 0,000 0,024447 0,05725876 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,024447 0,05720051 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,024447 0,05714238 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,024447 0,05708437 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,024447 0,05702647 ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,024447 0,05696869 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,024447 0,05691103 ! acid secretion GO:0046717 14 9 0,000 0,024447 0,05685349 ! musculoskeletal movement GO:0050881 11 9 0,000 0,024447 0,05679606 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,024447 0,05673875 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,024447 0,05668155 ! purine base metabolic process GO:0006144 18 9 0,000 0,024447 0,05662447 ! oocyte differentiation GO:0009994 12 9 0,000 0,024447 0,05656751 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,024447 0,05651065 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,024447 0,05645392 ! spleen development GO:0048536 15 9 0,000 0,024447 0,05639729 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,024447 0,05634078 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,024447 0,05628439 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,024447 0,0562281 ! detection of calcium ion GO:0005513 13 9 0,000 0,024447 0,05617193 ! blastocyst formation GO:0001825 12 9 0,000 0,024447 0,05611587 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,024447 0,05605992 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,024447 0,05600408 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,024447 0,05594836 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,024447 0,05589274 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,024447 0,05583724 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,024447 0,05578185 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,024447 0,05572656 ! prepulse inhibition GO:0060134 14 9 0,000 0,024447 0,05567139 ! embryonic placenta development GO:0001892 12 9 0,000 0,024447 0,05561632 ! insulin secretion GO:0030073 17 9 0,000 0,024447 0,05556136 ! sequestering of metal ion GO:0051238 11 9 0,000 0,024447 0,05550652 ! response to nicotine GO:0035094 16 9 0,000 0,024447 0,05545178 ! establishment of cell polarity GO:0030010 12 9 0,000 0,024447 0,05539714 ! nucleus localization GO:0051647 15 9 0,000 0,024447 0,05534262 ! regulation of synapse organization GO:0050807 12 9 0,000 0,024447 0,0552882 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,0248424 0,05612723 ! reproductive developmental process GO:0003006 127 89 1,000 0,0248424 0,05607214 ! regulation of T cell activation GO:0050863 128 89 1,000 0,0248424 0,05601717 ! leukocyte differentiation GO:0002521 143 90 1,000 0,02536313 0,05713536 ! response to virus GO:0009615 122 91 1,000 0,02588832 0,05826138 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,02641794 0,05939517 ! cell fate commitment GO:0045165 141 92 1,000 0,02641794 0,05933717 ! positive regulation of immune response GO:0050778 121 92 1,000 0,02641794 0,05927928 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,02695196 0,06041863 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02712694 0,06075166 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02712694 0,06069256 ! neuron fate specification GO:0048665 11 10 0,000 0,02712694 0,06063358 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02712694 0,06057471 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02712694 0,06051596 ! thyroid gland development GO:0030878 19 10 0,000 0,02712694 0,06045732 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02712694 0,0603988 ! synapsis GO:0007129 13 10 0,000 0,02712694 0,06034038 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02712694 0,06028208 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02712694 0,0602239 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02712694 0,06016582 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02712694 0,06010786 ! sulfate transport GO:0008272 12 10 0,000 0,02712694 0,06005001 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02712694 0,05999227 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02712694 0,05993464 ! androgen metabolic process GO:0008209 13 10 0,000 0,02712694 0,05987712 ! phospholipid efflux GO:0033700 16 10 0,000 0,02712694 0,05981971 ! hippocampus development GO:0021766 19 10 0,000 0,02712694 0,05976241 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02712694 0,05970522 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02712694 0,05964814 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02712694 0,05959117 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02712694 0,05953431 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02712694 0,05947756 ! pathogenesis GO:0009405 13 10 0,000 0,02712694 0,05942091 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02712694 0,05936437 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02712694 0,05930794 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02712694 0,05925162 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02712694 0,0591954 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02712694 0,0591393 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02712694 0,05908329 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02712694 0,05902739 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02712694 0,0589716 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02712694 0,05891592 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02712694 0,05886034 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02712694 0,05880486 ! response to X-ray GO:0010165 16 10 0,000 0,02712694 0,05874949 ! B cell proliferation GO:0042100 14 10 0,000 0,02712694 0,05869422 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02712694 0,05863906 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02712694 0,058584 ! forebrain cell migration GO:0021885 17 10 0,000 0,02712694 0,05852904 ! lipid digestion GO:0044241 15 10 0,000 0,02712694 0,05847419 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02712694 0,05841943 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02712694 0,05836479 ! UV protection GO:0009650 14 10 0,000 0,02712694 0,05831024 ! entry into host cell GO:0030260 20 10 0,000 0,02712694 0,0582558 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02712694 0,05820145 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02712694 0,05814721 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02712694 0,05809307 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02712694 0,05803903 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02712694 0,05798509 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02712694 0,05793125 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02712694 0,05787751 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02712694 0,05782387 ! regulation of organ growth GO:0046620 11 10 0,000 0,02712694 0,05777033 ! response to dsRNA GO:0043331 18 10 0,000 0,02712694 0,05771689 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02712694 0,05766355 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02712694 0,0576103 ! embryonic axis specification GO:0000578 12 10 0,000 0,02712694 0,05755716 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02712694 0,05750411 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02712694 0,05745116 ! cranial nerve development GO:0021545 12 10 0,000 0,02712694 0,0573983 ! fucose catabolic process GO:0019317 16 10 0,000 0,02712694 0,05734555 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02712694 0,05729289 GO:0006305|DNA alkylation, ! protein sumoylation GO:0016925 12 10 0,000 0,02712694 0,05724033 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02712694 0,05718786 ! zymogen activation GO:0031638 14 10 0,000 0,02712694 0,05713549 ! salivary gland development GO:0007431 22 10 0,000 0,02712694 0,05708322 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02712694 0,05703104 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02712694 0,05697896 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02712694 0,05692697 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02712694 0,05687507 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02712694 0,05682328 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02712694 0,05677157 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02712694 0,05671996 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02712694 0,05666844 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02712694 0,05661702 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,02712694 0,05656569 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02712694 0,05651445 ! detection of bacterium GO:0016045 10 10 0,000 0,02712694 0,05646331 ! embryonic gut development GO:0048566 11 10 0,000 0,02712694 0,05641226 ! activation of innate immune response GO:0002218 10 10 0,000 0,02712694 0,0563613 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02712694 0,05631043 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02712694 0,05625965 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02712694 0,05620897 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02712694 0,05615838 ! angiogenesis GO:0001525 149 95 1,000 0,02803312 0,05798216 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,02858019 0,05906059 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,02858019 0,05900757 ! response to light stimulus GO:0009416 153 96 1,000 0,02858019 0,05895465 ! rRNA transcription GO:0009303 17 11 0,000 0,02979967 0,06141508 ! respiratory burst GO:0045730 14 11 0,000 0,02979967 0,0613601 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,02979967 0,06130522 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,02979967 0,06125043 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,02979967 0,06119574 ! virus-host interaction GO:0019048 17 11 0,000 0,02979967 0,06114115 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,02979967 0,06108666 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,02979967 0,06103226 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,02979967 0,06097796 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,02979967 0,06092376 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,02979967 0,06086965 ! mating GO:0007618 14 11 0,000 0,02979967 0,06081564 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,02979967 0,06076173 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,02979967 0,06070791 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,02979967 0,06065419 ! bone resorption GO:0045453 16 11 0,000 0,02979967 0,06060056 ! regulated secretory pathway GO:0045055 14 11 0,000 0,02979967 0,06054702 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,02979967 0,06049358 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,02979967 0,06044024 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,02979967 0,06038699 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,02979967 0,06033383 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,02979967 0,06028077 ! syncytium formation GO:0006949 15 11 0,000 0,02979967 0,0602278 ! plasma membrane organization GO:0007009 18 11 0,000 0,02979967 0,06017492 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,02979967 0,06012213 ! focal adhesion formation GO:0048041 24 11 0,000 0,02979967 0,06006944 ! mitotic spindle organization GO:0007052 15 11 0,000 0,02979967 0,06001684 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,02979967 0,05996433 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,02979967 0,05991192 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,02979967 0,05985959 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,02979967 0,05980736 ! adult heart development GO:0007512 11 11 0,000 0,02979967 0,05975521 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,02979967 0,05970316 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,02979967 0,0596512 ! temperature homeostasis GO:0001659 16 11 0,000 0,02979967 0,05959933 ! L-glutamate transport GO:0015813 16 11 0,000 0,02979967 0,05954755 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,02979967 0,05949586 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,02979967 0,05944426 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,02979967 0,05939275 ! stem cell development GO:0048864 29 11 0,000 0,02979967 0,05934133 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,02979967 0,05928999 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,02979967 0,05923875 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,02979967 0,05918759 ! vasoconstriction GO:0042310 15 11 0,000 0,02979967 0,05913652 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,02979967 0,05908554 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,02979967 0,05903465 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,02979967 0,05898385 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,02979967 0,05893313 ! ribosome assembly GO:0042255 13 11 0,000 0,02979967 0,0588825 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,02979967 0,05883196 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,02979967 0,0587815 ! chromatin silencing GO:0006342 19 11 0,000 0,02979967 0,05873113 ! nucleosome positioning GO:0016584 13 11 0,000 0,02979967 0,05868085 ! T cell homeostasis GO:0043029 20 11 0,000 0,02979967 0,05863065 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,02979967 0,05858054 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,02979967 0,05853051 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,02979967 0,05848057 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,02979967 0,05843072 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,02979967 0,05838095 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,02979967 0,05833126 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,02979967 0,05828166 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,02979967 0,05823214 ! male genitalia development GO:0030539 13 11 0,000 0,02979967 0,05818271 ! cholesterol efflux GO:0033344 19 11 0,000 0,02979967 0,05813336 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,02979967 0,05808409 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,02979967 0,05803491 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,02979967 0,05798581 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,02979967 0,0579368 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,02979967 0,05788786 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,02979967 0,05783901 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,02979967 0,05779025 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,02979967 0,05774156 ! lysogeny GO:0030069 18 11 0,000 0,02979967 0,05769296 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,02979967 0,05764443 ! acrosome reaction GO:0007340 13 11 0,000 0,02979967 0,05759599 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,02979967 0,05754763 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,03024708 0,05836265 ! regulation of translation GO:0006417 151 100 1,000 0,03081118 0,05940126 ! lactation GO:0007595 20 12 0,000 0,0324652 0,06253766 ! reproductive cellular process GO:0048610 14 12 0,000 0,0324652 0,06248533 ! tRNA modification GO:0006400 14 12 0,000 0,0324652 0,06243308 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,0324652 0,06238093 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,0324652 0,06232886 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,0324652 0,06227687 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,0324652 0,06222497 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,0324652 0,06217316 ! non-recombinational repair GO:0000726 19 12 0,000 0,0324652 0,06212144 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,0324652 0,0620698 ! peroxisomal transport GO:0043574 21 12 0,000 0,0324652 0,06201825 ! cartilage condensation GO:0001502 18 12 0,000 0,0324652 0,06196678 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,0324652 0,0619154 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,0324652 0,0618641 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,0324652 0,06181289 ! heart looping GO:0001947 15 12 0,000 0,0324652 0,06176176 ! palate development GO:0060021 15 12 0,000 0,0324652 0,06171072 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,0324652 0,06165976 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,0324652 0,06160889 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,0324652 0,06155809 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,0324652 0,06150739 ! arginine metabolic process GO:0006525 13 12 0,000 0,0324652 0,06145676 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,0324652 0,06140622 ! methionine metabolic process GO:0006555 13 12 0,000 0,0324652 0,06135577 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,0324652 0,06130539 ! Golgi organization GO:0007030 18 12 0,000 0,0324652 0,0612551 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,0324652 0,06120489 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,0324652 0,06115477 ! monoamine transport GO:0015844 13 12 0,000 0,0324652 0,06110472 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0324652 0,06105476 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,0324652 0,06100488 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,0324652 0,06095508 ! L-amino acid transport GO:0015807 20 12 0,000 0,0324652 0,06090536 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,0324652 0,06085572 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,0324652 0,06080616 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,0324652 0,06075669 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,0324652 0,06070729 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,0324652 0,06065798 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,0324652 0,06060874 ! cerebellum development GO:0021549 13 12 0,000 0,0324652 0,06055959 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,0324652 0,06051051 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,0324652 0,06046151 ! histone acetylation GO:0016573 23 12 0,000 0,0324652 0,0604126 ! histone methylation GO:0016571 15 12 0,000 0,0324652 0,06036376 ! autonomic nervous system development GO:0048483 23 12 0,000 0,0324652 0,060315 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,0324652 0,06026632 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,0324652 0,06021772 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,0324652 0,06016919 ! response to gamma radiation GO:0010332 20 12 0,000 0,0324652 0,06012075 ! regulation of epidermis development GO:0045682 17 12 0,000 0,0324652 0,06007238 ! intestinal absorption GO:0050892 19 12 0,000 0,0324652 0,06002409 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,0324652 0,05997588 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,0324652 0,05992774 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,0324652 0,05987969 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,0324652 0,05983171 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,0324652 0,0597838 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,0324652 0,05973598 ! microspike assembly GO:0030035 23 12 0,000 0,0324652 0,05968822 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,0324652 0,05964055 ! response to cold GO:0009409 14 12 0,000 0,0324652 0,05959295 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,03512357 0,06442122 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,03512357 0,06436989 ! cGMP metabolic process GO:0046068 16 13 0,000 0,03512357 0,06431864 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,03512357 0,06426747 ! water transport GO:0006833 17 13 0,000 0,03512357 0,06421639 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,03512357 0,06416538 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,03512357 0,06411445 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,03512357 0,06406361 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,03512357 0,06401285 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,03512357 0,06396216 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,03512357 0,06391156 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,03512357 0,06386104 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,03512357 0,06381059 ! response to hexose stimulus GO:0009746 19 13 0,000 0,03512357 0,06376023 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,03512357 0,06370995 ! glutamate metabolic process GO:0006536 18 13 0,000 0,03512357 0,06365974 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,03512357 0,06360962 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,03512357 0,06355957 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,03512357 0,0635096 ! NAD metabolic process GO:0019674 21 13 0,000 0,03512357 0,06345971 ! exocrine system development GO:0035272 27 13 0,000 0,03512357 0,0634099 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,03512357 0,06336017 ! bone mineralization GO:0030282 15 13 0,000 0,03512357 0,06331051 ! regulation of exocytosis GO:0017157 17 13 0,000 0,03512357 0,06326093 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,03512357 0,06321143 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,03512357 0,06316201 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,03512357 0,06311267 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,03512357 0,0630634 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,03512357 0,06301421 ! genitalia development GO:0048806 15 13 0,000 0,03512357 0,06296509 ! regulation of cellular pH GO:0030641 20 13 0,000 0,03512357 0,06291605 ! cellular pigmentation GO:0033059 24 13 0,000 0,03512357 0,06286709 ! tissue regeneration GO:0042246 21 13 0,000 0,03512357 0,06281821 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,03512357 0,0627694 ! cofactor transport GO:0051181 19 13 0,000 0,03512357 0,06272066 ! NADP metabolic process GO:0006739 18 13 0,000 0,03512357 0,062672 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,03512357 0,06262342 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,03512357 0,06257491 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03512357 0,06252648 ! gas transport GO:0015669 18 13 0,000 0,03512357 0,06247812 ! regulation of RNA stability GO:0043487 28 13 0,000 0,03512357 0,06242984 ! heme biosynthetic process GO:0006783 20 13 0,000 0,03512357 0,06238163 ! regulation of axon extension GO:0030516 23 13 0,000 0,03512357 0,0623335 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,03512357 0,06228544 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,03512357 0,06223745 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,03512357 0,06218954 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,03512357 0,0621417 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,03512357 0,06209394 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,03512357 0,06204625 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,03777479 0,06667844 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,03777479 0,06662731 ! superoxide anion generation GO:0042554 18 14 0,000 0,03777479 0,06657625 ! neuron maturation GO:0042551 21 14 0,000 0,03777479 0,06652527 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,03777479 0,06647437 ! myotube differentiation GO:0014902 21 14 0,000 0,03777479 0,06642355 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,03777479 0,06637281 ! inositol metabolic process GO:0006020 20 14 0,000 0,03777479 0,06632214 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,03777479 0,06627155 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,03777479 0,06622104 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,03777479 0,06617061 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,03777479 0,06612025 ! gene silencing by RNA GO:0031047 20 14 0,000 0,03777479 0,06606997 ! response to cAMP GO:0051591 19 14 0,000 0,03777479 0,06601976 ! limbic system development GO:0021761 25 14 0,000 0,03777479 0,06596963 ! startle response GO:0001964 21 14 0,000 0,03777479 0,06591958 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,03777479 0,0658696 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,03777479 0,0658197 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,03777479 0,06576988 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,03777479 0,06572013 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,03777479 0,06567045 ! glycine metabolic process GO:0006544 22 14 0,000 0,03777479 0,06562085 ! pituitary gland development GO:0021983 23 14 0,000 0,03777479 0,06557133 ! cellular response to starvation GO:0009267 21 14 0,000 0,03777479 0,06552188 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,03777479 0,0654725 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,03777479 0,0654232 ! regulation of heart rate GO:0002027 23 14 0,000 0,03777479 0,06537397 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,03777479 0,06532482 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,03777479 0,06527574 ! embryo implantation GO:0007566 27 14 0,000 0,03777479 0,06522673 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,03777479 0,0651778 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,03777479 0,06512894 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,03777479 0,06508015 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,03777479 0,06503144 ! axon cargo transport GO:0008088 27 14 0,000 0,03777479 0,0649828 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,03777479 0,06493424 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,03777479 0,06488574 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03777479 0,06483732 ! mRNA splice site selection GO:0006376 26 14 0,000 0,03777479 0,06478897 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,03777479 0,06474069 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,03777479 0,06469248 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,03777479 0,06464435 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,03777479 0,06459629 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,03777479 0,0645483 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,03777479 0,06450038 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,03777479 0,06445253 ! muscle maintenance GO:0046716 19 14 0,000 0,03777479 0,06440475 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,03777479 0,06435704 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,03777479 0,06430941 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,03777479 0,06426184 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,03777479 0,06421434 ! cell killing GO:0001906 20 14 0,000 0,03777479 0,06416692 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,03777479 0,06411956 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,03777479 0,06407228 ! cilium assembly GO:0042384 20 14 0,000 0,03777479 0,06402506 ! peptide hormone secretion GO:0030072 23 14 0,000 0,03777479 0,06397791 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,04041887 0,06840573 ! positive regulation of cell size GO:0045793 20 15 0,000 0,04041887 0,06835544 ! metencephalon development GO:0022037 19 15 0,000 0,04041887 0,06830521 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,04041887 0,06825506 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,04041887 0,06820498 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,04041887 0,06815498 ! skin development GO:0043588 25 15 0,000 0,04041887 0,06810505 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,04041887 0,06805519 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,04041887 0,06800541 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,04041887 0,0679557 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,04041887 0,06790606 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,04041887 0,06785649 ! bile acid metabolic process GO:0008206 22 15 0,000 0,04041887 0,067807 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,04041887 0,06775758 ! adult walking behavior GO:0007628 25 15 0,000 0,04041887 0,06770823 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,04041887 0,06765895 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,04041887 0,06760974 ! myoblast differentiation GO:0045445 27 15 0,000 0,04041887 0,06756061 ! centrosome cycle GO:0007098 16 15 0,000 0,04041887 0,06751154 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,04041887 0,06746255 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,04041887 0,06741363 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,04041887 0,06736478 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,04041887 0,067316 ! cerebral cortex development GO:0021987 29 15 0,000 0,04041887 0,06726729 ! response to osmotic stress GO:0006970 22 15 0,000 0,04041887 0,06721865 ! vesicle coating GO:0006901 25 15 0,000 0,04041887 0,06717008 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,04041887 0,06712158 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,04041887 0,06707316 ! peptide secretion GO:0002790 27 15 0,000 0,04041887 0,0670248 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,04041887 0,06697651 ! neuron recognition GO:0008038 22 15 0,000 0,04041887 0,06692829 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,04041887 0,06688014 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,04041887 0,06683206 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,04041887 0,06678405 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,04041887 0,0667361 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,04041887 0,06668823 ! biomineral formation GO:0031214 18 15 0,000 0,04041887 0,06664043 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,04041887 0,06659269 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,04041887 0,06654502 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,04041887 0,06649742 ! dopamine metabolic process GO:0042417 30 15 0,000 0,04041887 0,06644989 ! organic cation transport GO:0015695 19 15 0,000 0,04041887 0,06640242 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,04041887 0,06635503 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,04041887 0,0663077 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,04041887 0,06626044 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,04041887 0,06621324 ! peptide hormone processing GO:0016486 19 15 0,000 0,04041887 0,06616612 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,04041887 0,06611906 ! protein secretion GO:0009306 27 16 0,000 0,04305583 0,07038267 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,04305583 0,07033268 ! hormone secretion GO:0046879 25 16 0,000 0,04305583 0,07028277 ! bone remodeling GO:0046849 24 16 0,000 0,04305583 0,07023292 ! endothelial cell migration GO:0043542 22 16 0,000 0,04305583 0,07018314 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,04305583 0,07013344 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,04305583 0,0700838 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04305583 0,07003424 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,04305583 0,06998475 ! glial cell development GO:0021782 24 16 0,000 0,04305583 0,06993532 ! patterning of blood vessels GO:0001569 24 16 0,000 0,04305583 0,06988597 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,04305583 0,06983668 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,04305583 0,06978747 ! protein polyubiquitination GO:0000209 26 16 0,000 0,04305583 0,06973832 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,04305583 0,06968924 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,04305583 0,06964024 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,04305583 0,0695913 ! fructose metabolic process GO:0006000 20 16 0,000 0,04305583 0,06954243 ! regulation of protein binding GO:0043393 27 16 0,000 0,04305583 0,06949363 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,04305583 0,06944489 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,04305583 0,06939623 ! protein export from nucleus GO:0006611 24 16 0,000 0,04305583 0,06934763 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,04305583 0,0692991 ! DNA replication initiation GO:0006270 25 16 0,000 0,04305583 0,06925064 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,04305583 0,06920225 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,04305583 0,06915392 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,04305583 0,06910566 ! diencephalon development GO:0021536 25 16 0,000 0,04305583 0,06905747 ! oogenesis GO:0048477 23 16 0,000 0,04305583 0,06900935 ! neural crest cell migration GO:0001755 24 16 0,000 0,04305583 0,06896129 ! G1 phase GO:0051318 27 16 0,000 0,04305583 0,0689133 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,04305583 0,06886538 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,04305583 0,06881752 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,04305583 0,06876973 ! steroid catabolic process GO:0006706 22 16 0,000 0,04305583 0,06872201 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,04305583 0,06867435 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,04305583 0,06862676 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,04305583 0,06857924 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,04305583 0,06853178 ! sperm-egg recognition GO:0035036 16 16 0,000 0,04305583 0,06848438 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,04305583 0,06843705 ! nerve development GO:0021675 18 16 0,000 0,04305583 0,06838979 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,04305583 0,06834259 ! negative regulation of translation GO:0017148 22 16 0,000 0,04305583 0,06829546 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,0456857 0,07241704 ! negative regulation of defense response GO:0031348 19 17 0,000 0,0456857 0,07236716 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,0456857 0,07231736 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,0456857 0,07226762 ! glycerol metabolic process GO:0006071 20 17 0,000 0,0456857 0,07221795 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,0456857 0,07216835 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,0456857 0,07211882 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,0456857 0,07206935 ! signal complex assembly GO:0007172 29 17 0,000 0,0456857 0,07201996 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,0456857 0,07197063 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,0456857 0,07192137 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,0456857 0,07187217 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,0456857 0,07182305 ! memory GO:0007613 25 17 0,000 0,0456857 0,07177399 ! keratinization GO:0031424 17 17 0,000 0,0456857 0,071725 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,0456857 0,07167607 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,0456857 0,07162721 ! retinoid metabolic process GO:0001523 22 17 0,000 0,0456857 0,07157842 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,0456857 0,07152969 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,0456857 0,07148103 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,0456857 0,07143244 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,0456857 0,07138391 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,0456857 0,07133545 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,0456857 0,07128705 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,0456857 0,07123872 ! membrane budding GO:0006900 29 17 0,000 0,0456857 0,07119046 ! heme metabolic process GO:0042168 27 17 0,000 0,0456857 0,07114226 ! actin filament bundle formation GO:0051017 26 17 0,000 0,0456857 0,07109413 ! neuromuscular junction development GO:0007528 23 17 0,000 0,0456857 0,07104606 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,0456857 0,07099805 ! body fluid secretion GO:0007589 27 17 0,000 0,0456857 0,07095011 ! stem cell differentiation GO:0048863 36 17 0,000 0,0456857 0,07090224 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,0456857 0,07085443 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,0456857 0,07080668 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,0456857 0,070759 ! sensory perception of pain GO:0019233 23 17 0,000 0,0456857 0,07071139 ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,0456857 0,07066383 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,0456857 0,07061634 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,0456857 0,07056892 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,0456857 0,07052156 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,0456857 0,07047426 ! cell-cell junction organization GO:0045216 25 17 0,000 0,0456857 0,07042702 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,0456857 0,07037985 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,0456857 0,07033274 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,0456857 0,0702857 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,0456857 0,07023872 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,0456857 0,0701918 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,0483085 0,07417192 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,0483085 0,07412244 ! positive regulation of translation GO:0045727 28 18 0,000 0,0483085 0,07407303 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,0483085 0,07402368 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,0483085 0,0739744 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,0483085 0,07392518 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,0483085 0,07387603 ! cAMP metabolic process GO:0046058 33 18 0,000 0,0483085 0,07382694 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,0483085 0,07377792 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,0483085 0,07372896 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,0483085 0,07368007 ! axis specification GO:0009798 26 18 0,000 0,0483085 0,07363124 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,0483085 0,07358248 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,0483085 0,07353378 ! pancreas development GO:0031016 26 18 0,000 0,0483085 0,07348515 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,0483085 0,07343658 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,0483085 0,07338807 ! glutamine metabolic process GO:0006541 23 18 0,000 0,0483085 0,07333963 ! response to retinoic acid GO:0032526 25 18 0,000 0,0483085 0,07329126 ! pigmentation during development GO:0048066 31 18 0,000 0,0483085 0,07324294 ! central nervous system neuron development GO:0021954 30 18 0,000 0,0483085 0,07319469 ! fucose metabolic process GO:0006004 26 18 0,000 0,0483085 0,07314651 ! response to fungus GO:0009620 19 18 0,000 0,0483085 0,07309838 ! peptide cross-linking GO:0018149 31 18 0,000 0,0483085 0,07305032 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,0483085 0,07300233 ! heart process GO:0003015 27 18 0,000 0,0483085 0,07295439 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,0483085 0,07290652 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,0483085 0,07285872 ! visual learning GO:0008542 35 18 0,000 0,0483085 0,07281097 ! somitogenesis GO:0001756 24 18 0,000 0,0483085 0,07276329 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,0483085 0,07271567 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,0483085 0,07266811 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,0483085 0,07262062 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,0483085 0,07257318 ! vitamin transport GO:0051180 24 18 0,000 0,0483085 0,07252581 ! hormone transport GO:0009914 27 18 0,000 0,0483085 0,0724785 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,0483085 0,07243125 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,0483085 0,07238407 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,0483085 0,07233694 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,0483085 0,07228988 ! cell-cell recognition GO:0009988 20 18 0,000 0,0483085 0,07224288 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,0483085 0,07219593 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,0483085 0,07214905 ! regulation of glucose import GO:0046324 21 18 0,000 0,0483085 0,07210223 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,0483085 0,07205548 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,0483085 0,07200878 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,0483085 0,07196214 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,0483085 0,07191556 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,05092423 0,0757605 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,05092423 0,07571153 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,05092423 0,07566262 ! positive regulation of ossification GO:0045778 30 19 0,000 0,05092423 0,07561377 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,05092423 0,07556499 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,05092423 0,07551627 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,05092423 0,07546761 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,05092423 0,07541902 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,05092423 0,07537048 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,05092423 0,07532202 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,05092423 0,07527361 ! regeneration GO:0031099 32 19 0,000 0,05092423 0,07522526 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,05092423 0,07517698 ! response to alkaloid GO:0043279 32 19 0,000 0,05092423 0,07512876 ! sensory perception of taste GO:0050909 23 19 0,000 0,05092423 0,0750806 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,05092423 0,0750325 ! smooth muscle contraction GO:0006939 36 19 0,000 0,05092423 0,07498446 ! peroxisome organization GO:0007031 29 19 0,000 0,05092423 0,07493649 ! digestive system process GO:0022600 30 19 0,000 0,05092423 0,07488858 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,05092423 0,07484072 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,05092423 0,07479293 ! response to vitamin A GO:0033189 26 19 0,000 0,05092423 0,0747452 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,05092423 0,07469753 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,05092423 0,07464993 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,05092423 0,07460238 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,05092423 0,07455489 ! response to starvation GO:0042594 30 19 0,000 0,05092423 0,07450746 ! sex determination GO:0007530 29 19 0,000 0,05092423 0,0744601 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,05092423 0,07441279 ! plasma membrane fusion GO:0045026 23 19 0,000 0,05092423 0,07436555 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,05092423 0,07431836 ! cytolysis GO:0019835 20 19 0,000 0,05092423 0,07427123 ! renal system process GO:0003014 35 19 0,000 0,05092423 0,07422417 ! vasodilation GO:0042311 33 19 0,000 0,05092423 0,07417716 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,05092423 0,07413021 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,05092423 0,07408332 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,05092423 0,07403649 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,05092423 0,07398972 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,05092423 0,07394301 ! sarcomere organization GO:0045214 23 19 0,000 0,05092423 0,07389636 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,05092423 0,07384977 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,05092423 0,07380323 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,05092423 0,07375676 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,05092423 0,07371034 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,05092423 0,07366398 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,05092423 0,07361768 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,05092423 0,07357144 ! protein stabilization GO:0050821 26 19 0,000 0,05092423 0,07352526 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,05353293 0,07724324 ! iron ion transport GO:0006826 37 20 0,000 0,05353293 0,07719482 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,05353293 0,07714645 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,05353293 0,07709814 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,05353293 0,07704989 ! response to vitamin GO:0033273 29 20 0,000 0,05353293 0,07700171 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,05353293 0,07695358 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,05353293 0,07690552 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,05353293 0,07685751 ! spinal cord development GO:0021510 31 20 0,000 0,05353293 0,07680956 ! response to ethanol GO:0045471 37 20 0,000 0,05353293 0,07676168 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,05353293 0,07671385 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,05353293 0,07666608 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,05353293 0,07661838 ! chromosome condensation GO:0030261 31 20 0,000 0,05353293 0,07657073 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,05353293 0,07652314 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,05353293 0,07647561 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,05353293 0,07642814 ! pallium development GO:0021543 38 20 0,000 0,05353293 0,07638073 ! DNA modification GO:0006304 28 20 0,000 0,05353293 0,07633337 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,05353293 0,07628608 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,05353293 0,07623884 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,05353293 0,07619167 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,05353293 0,07614455 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,05353293 0,07609749 ! collagen catabolic process GO:0030574 25 20 0,000 0,05353293 0,07605048 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,05353293 0,07600354 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,05353293 0,07595665 ! alditol metabolic process GO:0019400 24 20 0,000 0,05353293 0,07590982 ! actin filament-based movement GO:0030048 34 20 0,000 0,05353293 0,07586305 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,0561346 0,07950097 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,0561346 0,07945205 GO:0016444|somatic cell DNA recombination, ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,0561346 0,07940319 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,0561346 0,07935438 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,0561346 0,07930564 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,0561346 0,07925696 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,0561346 0,07920833 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,0561346 0,07915977 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,0561346 0,07911126 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,0561346 0,07906282 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,0561346 0,07901443 ! protein amino acid acylation GO:0043543 37 21 0,000 0,0561346 0,0789661 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,0561346 0,07891784 ! phototransduction GO:0007602 25 21 0,000 0,0561346 0,07886963 ! dendrite development GO:0016358 35 21 0,000 0,0561346 0,07882148 ! visual behavior GO:0007632 39 21 0,000 0,0561346 0,07877339 ! ovarian follicle development GO:0001541 30 21 0,000 0,0561346 0,07872535 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,0561346 0,07867738 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,0561346 0,07862946 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,0561346 0,07858161 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,0561346 0,07853381 ! cell aging GO:0007569 32 21 0,000 0,0561346 0,07848607 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,0561346 0,07843838 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,0561346 0,07839076 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,0561346 0,07834319 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,0561346 0,07829568 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,0561346 0,07824823 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,0561346 0,07820084 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,0561346 0,0781535 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,0561346 0,07810622 ! fatty acid transport GO:0015908 30 21 0,000 0,0561346 0,078059 ! platelet activation GO:0030168 28 21 0,000 0,0561346 0,07801183 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,0561346 0,07796472 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,0561346 0,07791767 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,0561346 0,07787068 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,0561346 0,07782374 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,0561346 0,07777686 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,0561346 0,07773003 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,0561346 0,07768326 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,0561346 0,07763655 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,0561346 0,07758989 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,0561346 0,07754329 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,0561346 0,07749675 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,0561346 0,07745026 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,0561346 0,07740382 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,05872927 0,08093309 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,05872927 0,08088462 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,05872927 0,08083622 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,05872927 0,08078787 ! viral genome replication GO:0019079 29 22 0,000 0,05872927 0,08073958 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,05872927 0,08069135 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,05872927 0,08064318 ! molting cycle process GO:0022404 40 22 0,000 0,05872927 0,08059506 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,05872927 0,080547 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,05872927 0,080499 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,05872927 0,08045106 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,05872927 0,08040317 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,05872927 0,08035534 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,05872927 0,08030756 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,05872927 0,08025985 ! lysosome organization GO:0007040 37 22 0,000 0,05872927 0,08021219 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,05872927 0,08016458 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,05872927 0,08011704 ! regulation of behavior GO:0050795 38 22 0,000 0,05872927 0,08006954 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,05872927 0,08002211 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,05872927 0,07997473 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,05872927 0,07992741 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,05872927 0,07988014 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,05872927 0,07983293 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,05872927 0,07978578 ! blastocyst development GO:0001824 37 22 0,000 0,05872927 0,07973868 ! neural tube closure GO:0001843 33 22 0,000 0,05872927 0,07969164 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,05872927 0,07964465 ! protein tetramerization GO:0051262 39 22 0,000 0,05872927 0,07959771 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,06131696 0,08305595 ! neuron fate commitment GO:0048663 32 23 0,000 0,06131696 0,08300706 ! embryonic pattern specification GO:0009880 31 23 0,000 0,06131696 0,08295823 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,06131696 0,08290946 ! myelination GO:0042552 35 23 0,000 0,06131696 0,08286075 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,06131696 0,0828121 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,06131696 0,0827635 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,06131696 0,08271496 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,06131696 0,08266647 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,06131696 0,08261804 ! vesicle targeting GO:0006903 32 23 0,000 0,06131696 0,08256967 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,06131696 0,08252136 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,06131696 0,0824731 ! osteoblast differentiation GO:0001649 40 23 0,000 0,06131696 0,0824249 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,06131696 0,08237675 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,06131696 0,08232866 ! interaction with host GO:0051701 37 23 0,000 0,06131696 0,08228063 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,06131696 0,08223265 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,06131696 0,08218473 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,06131696 0,08213687 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,06131696 0,08208906 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,06131696 0,0820413 ! cell fate determination GO:0001709 45 23 0,000 0,06131696 0,0819936 ! pentose metabolic process GO:0019321 31 23 0,000 0,06131696 0,08194596 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,06131696 0,08189837 ! spermatid development GO:0007286 33 23 0,000 0,06131696 0,08185084 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,06131696 0,08180336 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,06131696 0,08175594 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,06131696 0,08170857 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,06131696 0,08166126 ! telomere organization GO:0032200 32 23 0,000 0,06131696 0,081614 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,06131696 0,0815668 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,06131696 0,08151965 ! regulation of amine transport GO:0051952 38 23 0,000 0,06131696 0,08147256 ! liver development GO:0001889 40 23 0,000 0,06131696 0,08142552 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,06389768 0,08480361 ! initiation of viral infection GO:0019059 42 24 0,000 0,06389768 0,0847547 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,06389768 0,08470585 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,06389768 0,08465706 ! superoxide metabolic process GO:0006801 32 24 0,000 0,06389768 0,08460832 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,06389768 0,08455964 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,06389768 0,08451101 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,06389768 0,08446245 ! sperm motility GO:0030317 27 24 0,000 0,06389768 0,08441393 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,06389768 0,08436547 ! vacuole organization GO:0007033 39 24 0,000 0,06389768 0,08431707 ! receptor metabolic process GO:0043112 37 24 0,000 0,06389768 0,08426872 ! neural crest cell development GO:0014032 39 24 0,000 0,06389768 0,08422043 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,06389768 0,0841722 ! primary neural tube formation GO:0014020 35 24 0,000 0,06389768 0,08412402 ! negative regulation of cell development GO:0010721 56 24 0,000 0,06389768 0,08407589 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 0,000 0,06389768 0,08402782 ! glutathione metabolic process GO:0006749 29 24 0,000 0,06389768 0,0839798 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,06389768 0,08393184 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,06389768 0,08388394 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,06389768 0,08383608 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,06647145 0,08716324 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,06647145 0,08711358 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,06647145 0,08706397 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,06647145 0,08701442 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,06647145 0,08696492 ! peptide transport GO:0015833 43 25 0,000 0,06647145 0,08691548 ! male gonad development GO:0008584 33 25 0,000 0,06647145 0,0868661 ! iron ion homeostasis GO:0055072 39 25 0,000 0,06647145 0,08681677 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,06647145 0,0867675 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,06647145 0,08671828 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,06647145 0,08666912 ! phospholipid transport GO:0015914 35 25 0,000 0,06647145 0,08662002 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,06647145 0,08657097 ! detection of light stimulus GO:0009583 30 25 0,000 0,06647145 0,08652198 ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,06647145 0,08647304 ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,06647145 0,08642416 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,06903829 0,08971077 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,06903829 0,08966012 ! translational initiation GO:0006413 43 26 0,000 0,06903829 0,08960952 ! regulation of pH GO:0006885 36 26 0,000 0,06903829 0,08955898 ! circadian rhythm GO:0007623 42 26 0,000 0,06903829 0,08950849 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,06903829 0,08945807 ! post-embryonic development GO:0009791 42 26 0,000 0,06903829 0,0894077 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,06903829 0,08935738 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,06903829 0,08930712 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,06903829 0,08925692 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,06903829 0,08920678 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,06903829 0,08915669 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,07159822 0,09241072 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,07159822 0,0923589 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,07159822 0,09230712 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,07159822 0,09225541 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,07159822 0,09220376 ! catechol metabolic process GO:0009712 43 27 0,000 0,07159822 0,09215216 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,07159822 0,09210062 ! acute-phase response GO:0006953 42 27 0,000 0,07159822 0,09204914 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,07159822 0,09199772 ! myofibril assembly GO:0030239 36 27 0,000 0,07159822 0,09194635 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,07159822 0,09189504 ! response to ionizing radiation GO:0010212 47 27 0,000 0,07159822 0,09184379 ! natural killer cell activation GO:0030101 35 27 0,000 0,07159822 0,09179259 ! lipid oxidation GO:0034440 38 27 0,000 0,07159822 0,09174145 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,07159822 0,09169037 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,07159822 0,09163935 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,07159822 0,09158838 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,07159822 0,09153747 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,07159822 0,09148662 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,07159822 0,09143582 ! gene silencing GO:0016458 41 27 0,000 0,07159822 0,09138508 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,07415126 0,09459118 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,07415126 0,09453875 ! phenol metabolic process GO:0018958 44 28 0,000 0,07415126 0,09448637 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,07415126 0,09443405 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,07415126 0,09438179 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,07415126 0,09432959 ! cell junction assembly GO:0034329 56 28 0,000 0,07415126 0,09427745 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,07415126 0,09422536 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,07415126 0,09417333 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,07415126 0,09412136 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,07415126 0,09406944 ! response to organic cyclic substance GO:0014070 47 28 0,000 0,07415126 0,09401758 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,07415126 0,09396578 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,07415126 0,09391404 ! mesoderm formation GO:0001707 46 28 0,000 0,07415126 0,09386235 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,07415126 0,09381073 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,07415126 0,09375915 ! ensheathment of neurons GO:0007272 43 28 0,000 0,07415126 0,09370764 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,07415126 0,09365618 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,07415126 0,09360477 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,07415126 0,09355343 ! neural tube formation GO:0001841 41 28 0,000 0,07415126 0,09350214 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,07415126 0,0934509 ! placenta development GO:0001890 37 28 0,000 0,07415126 0,09339973 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,07669742 0,09655395 ! regulation of innate immune response GO:0045088 38 29 0,000 0,07669742 0,09650114 ! ovulation cycle process GO:0022602 41 29 0,000 0,07669742 0,09644837 ! protein targeting to membrane GO:0006612 53 29 0,000 0,07669742 0,09639567 ! mismatch repair GO:0006298 34 29 0,000 0,07669742 0,09634302 ! muscle cell development GO:0055001 38 29 0,000 0,07669742 0,09629043 ! formation of primary germ layer GO:0001704 48 29 0,000 0,07669742 0,0962379 ! telencephalon development GO:0021537 52 29 0,000 0,07669742 0,09618543 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,07669742 0,09613301 ! eye morphogenesis GO:0048592 51 29 0,000 0,07669742 0,09608065 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,07669742 0,09602835 ! tissue homeostasis GO:0001894 42 29 0,000 0,07669742 0,0959761 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,07923673 0,09909977 ! collagen metabolic process GO:0032963 40 30 0,000 0,07923673 0,09904591 ! organic anion transport GO:0015711 51 30 0,000 0,07923673 0,09899211 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,07923673 0,09893837 ! spliceosome assembly GO:0000245 49 30 0,000 0,07923673 0,09888469 ! spindle organization GO:0007051 37 30 0,000 0,07923673 0,09883106 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,07923673 0,0987775 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,07923673 0,09872399 ! ceramide metabolic process GO:0006672 43 30 0,000 0,07923673 0,09867054 ! ovulation cycle GO:0042698 43 30 0,000 0,07923673 0,09861714 ! hindbrain development GO:0030902 45 30 0,000 0,07923673 0,09856381 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,07923673 0,09851053 ! adult locomotory behavior GO:0008344 47 30 0,000 0,07923673 0,09845731 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,07923673 0,09840415 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,07923673 0,09835104 ! response to heat GO:0009408 41 30 0,000 0,07923673 0,09829799 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,07923673 0,098245 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,0817692 0,10133037 ! negative regulation of secretion GO:0051048 49 31 0,000 0,0817692 0,1012758 ! glial cell differentiation GO:0010001 55 31 0,000 0,0817692 0,10122129 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,0817692 0,10116684 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,0817692 0,10111245 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,0817692 0,10105812 ! odontogenesis GO:0042476 50 31 0,000 0,0817692 0,10100384 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,0817692 0,10094963 ! segmentation GO:0035282 41 31 0,000 0,0817692 0,10089547 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,0817692 0,10084137 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,0817692 0,10078733 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,0817692 0,10073335 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,0817692 0,10067942 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,0817692 0,10062555 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,0817692 0,10057174 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,0817692 0,10051799 ! RNA modification GO:0009451 40 31 0,000 0,0817692 0,10046429 ! regulation of muscle development GO:0048634 48 32 0,000 0,08429485 0,10351209 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,08429485 0,10345686 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,08429485 0,10340168 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,08429485 0,10334656 ! meiosis I GO:0007127 52 32 0,000 0,08429485 0,1032915 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,08429485 0,1032365 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,08429485 0,10318156 ! peripheral nervous system development GO:0007422 53 32 0,000 0,08429485 0,10312667 ! regulation of protein stability GO:0031647 48 32 0,000 0,08429485 0,10307185 ! cytokine production GO:0001816 44 32 0,000 0,08429485 0,10301708 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,08429485 0,10296237 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,08429485 0,10290772 ! vesicle localization GO:0051648 47 32 0,000 0,08429485 0,10285313 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,08681369 0,10587036 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,08681369 0,10581425 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,08681369 0,10575821 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,08681369 0,10570222 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,08681369 0,10564629 ! sister chromatid segregation GO:0000819 46 33 0,000 0,08681369 0,10559042 ! ear morphogenesis GO:0042471 42 33 0,000 0,08681369 0,10553461 ! actomyosin structure organization GO:0031032 43 33 0,000 0,08681369 0,10547887 ! cell junction organization GO:0034330 63 33 0,000 0,08681369 0,10542317 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,08681369 0,10536754 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,08681369 0,10531197 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,08681369 0,10525645 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,08681369 0,105201 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,08681369 0,1051456 ! female gonad development GO:0008585 49 33 0,000 0,08681369 0,10509026 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,08681369 0,10503498 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,08681369 0,10497975 ! regulation of proteolysis GO:0030162 50 33 0,000 0,08681369 0,10492459 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,08681369 0,10486948 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,08681369 0,10481443 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,08681369 0,10475944 ! cytokinesis GO:0000910 52 33 0,000 0,08681369 0,10470451 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,08681369 0,10464963 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,08932575 0,10762139 ! mRNA catabolic process GO:0006402 48 34 0,000 0,08932575 0,10756504 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,08932575 0,10750875 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,08932575 0,10745253 ! feeding behavior GO:0007631 45 34 0,000 0,08932575 0,10739636 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,08932575 0,10734025 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,08932575 0,10728419 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,08932575 0,1072282 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,08932575 0,10717226 ! neuron migration GO:0001764 46 34 0,000 0,08932575 0,10711639 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,08932575 0,10706057 ! female gamete generation GO:0007292 43 34 0,000 0,08932575 0,10700481 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,08932575 0,1069491 ! polyol metabolic process GO:0019751 44 34 0,000 0,08932575 0,10689346 ! aerobic respiration GO:0009060 47 34 0,000 0,08932575 0,10683787 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,08932575 0,10678234 ! embryonic organ development GO:0048568 45 34 0,000 0,08932575 0,10672687 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,09183105 0,10966324 ! Notch signaling pathway GO:0007219 56 35 0,000 0,09183105 0,10960633 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,09183105 0,10954948 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,09183105 0,10949269 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,09183105 0,10943596 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,09183105 0,10937929 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,09183105 0,10932267 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,09183105 0,10926612 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,09183105 0,10920962 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,09183105 0,10915318 ! glycogen metabolic process GO:0005977 48 35 0,000 0,09183105 0,1090968 ! pigment metabolic process GO:0042440 61 35 0,000 0,09183105 0,10904048 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,09432959 0,11194946 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,09432959 0,11189173 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,09432959 0,11183405 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,09432959 0,11177643 ! negative regulation of binding GO:0051100 58 36 0,000 0,09432959 0,11171888 ! neural tube development GO:0021915 50 36 0,000 0,09432959 0,11166138 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,09432959 0,11160394 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,09432959 0,11154656 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,09432959 0,11148924 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,09432959 0,11143198 ! glucan metabolic process GO:0044042 49 36 0,000 0,09432959 0,11137477 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,0968214 0,1142582 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,0968214 0,11419961 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,0968214 0,11414107 ! learning GO:0007612 67 37 0,000 0,0968214 0,1140826 ! ion transmembrane transport GO:0034220 56 37 0,000 0,0968214 0,11402418 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,0968214 0,11396583 ! regulation of protein secretion GO:0050708 51 37 0,000 0,0968214 0,11390753 ! amino acid activation GO:0043038 52 37 0,000 0,0968214 0,1138493 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,0968214 0,11379112 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,0993065 0,11665218 ! gliogenesis GO:0042063 71 38 0,000 0,0993065 0,11659263 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,0993065 0,11653314 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,0993065 0,11647372 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,0993065 0,11641435 ! phagocytosis GO:0006909 60 38 0,000 0,0993065 0,11635505 ! mesenchymal cell development GO:0014031 64 38 0,000 0,0993065 0,1162958 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,0993065 0,11623662 ! maintenance of location in cell GO:0051651 69 38 0,000 0,0993065 0,1161775 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,10178491 0,11901642 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,10178491 0,11895594 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,10178491 0,11889553 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,10178491 0,11883517 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,10178491 0,11877488 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,10178491 0,11871465 ! male sex differentiation GO:0046661 53 39 0,000 0,10178491 0,11865448 ! chromatin remodeling GO:0006338 68 39 0,000 0,10178491 0,11859437 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,10178491 0,11853432 ! JNK cascade GO:0007254 54 39 0,000 0,10178491 0,11847434 ! developmental growth GO:0048589 62 39 0,000 0,10178491 0,11841441 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,10425664 0,12122865 ! response to calcium ion GO:0051592 58 40 0,000 0,10425664 0,12116739 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,10425664 0,12110619 ! regulation of tube size GO:0035150 60 40 0,000 0,10425664 0,12104506 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,10425664 0,12098399 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,10425664 0,12092298 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,10425664 0,12086203 ! peptide metabolic process GO:0006518 56 40 0,000 0,10425664 0,12080114 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,10425664 0,12074031 ! inner ear development GO:0048839 57 40 0,000 0,10425664 0,12067955 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,10425664 0,12061884 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,10425664 0,1205582 ! B cell differentiation GO:0030183 62 40 0,000 0,10425664 0,12049762 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,10425664 0,1204371 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,10425664 0,12037664 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,10425664 0,12031624 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,1067217 0,12309925 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,1067217 0,12303755 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,1067217 0,12297591 ! glucose transport GO:0015758 52 41 0,000 0,1067217 0,12291433 ! endosome transport GO:0016197 71 41 0,000 0,1067217 0,12285281 ! striated muscle contraction GO:0006941 62 41 0,000 0,1067217 0,12279135 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,1067217 0,12272996 ! biopolymer methylation GO:0043414 62 41 0,000 0,1067217 0,12266862 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,1067217 0,12260735 ! mitochondrial transport GO:0006839 60 42 0,000 0,10918012 0,12536909 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,10918012 0,12530653 ! cellular component disassembly GO:0022411 64 42 0,000 0,10918012 0,12524403 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,10918012 0,1251816 ! hexose transport GO:0008645 54 42 0,000 0,10918012 0,12511923 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,10918012 0,12505692 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,10918012 0,12499467 ! excretion GO:0007588 63 42 0,000 0,10918012 0,12493248 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,10918012 0,12487036 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,10918012 0,12480829 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,10918012 0,12474629 ! regulation of cell shape GO:0008360 78 42 0,000 0,10918012 0,12468435 ! positive regulation of binding GO:0051099 59 43 0,000 0,11163192 0,12742105 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,11163192 0,12735785 ! leukocyte migration GO:0050900 60 43 0,000 0,11163192 0,12729471 ! neuromuscular process GO:0050905 79 43 0,000 0,11163192 0,12723163 ! activation of caspase activity GO:0006919 65 43 0,000 0,11163192 0,12716861 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,11163192 0,12710565 ! tRNA processing GO:0008033 49 43 0,000 0,11163192 0,12704276 ! methylation GO:0032259 64 43 0,000 0,11163192 0,12697993 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,11407711 0,12969716 ! glycolysis GO:0006096 53 44 0,000 0,11407711 0,12963308 ! regulation of action potential GO:0001508 71 44 0,000 0,11407711 0,12956907 ! regulation of ion transport GO:0043269 57 44 0,000 0,11407711 0,12950511 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,11407711 0,12944122 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,11407711 0,1293774 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,11407711 0,12931363 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,11407711 0,12924993 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,11407711 0,12918629 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,11407711 0,12912272 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,11407711 0,1290592 ! RNA catabolic process GO:0006401 64 45 0,000 0,11651571 0,13175326 ! positive regulation of defense response GO:0031349 59 45 0,000 0,11651571 0,13168852 ! regulation of translational initiation GO:0006446 64 45 0,000 0,11651571 0,13162384 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,11651571 0,13155922 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,11651571 0,13149467 ! cell recognition GO:0008037 58 45 0,000 0,11651571 0,13143018 ! cell maturation GO:0048469 60 45 0,000 0,11651571 0,13136575 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,11894774 0,13404204 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,11894774 0,13397639 ! cell redox homeostasis GO:0045454 63 46 0,000 0,11894774 0,13391082 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,11894774 0,1338453 ! regulation of ossification GO:0030278 71 46 0,000 0,11894774 0,13377985 ! histone modification GO:0016570 68 46 0,000 0,11894774 0,13371447 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,12137321 0,13637439 ! viral infectious cycle GO:0019058 71 47 0,000 0,12137321 0,1363078 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,12137321 0,13624128 ! endocrine system development GO:0035270 83 47 0,000 0,12137321 0,13617482 ! covalent chromatin modification GO:0016569 75 47 0,000 0,12137321 0,13610843 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,12137321 0,1360421 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,12137321 0,13597583 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,12137321 0,13590963 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,12137321 0,13584349 ! chloride transport GO:0006821 67 48 0,000 0,12379214 0,13848343 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,12379214 0,1384161 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 0,000 0,12379214 0,13834885 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,12379214 0,13828165 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,12379214 0,13821453 ! gastrulation GO:0007369 73 48 0,000 0,12379214 0,13814747 ! heart morphogenesis GO:0003007 65 48 0,000 0,12379214 0,13808047 ! regulation of DNA replication GO:0006275 75 48 0,000 0,12379214 0,13801354 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,12379214 0,13794667 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,12379214 0,13787987 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,12379214 0,13781313 ! regulation of endocytosis GO:0030100 63 48 0,000 0,12379214 0,13774646 ! nuclear export GO:0051168 69 48 0,000 0,12379214 0,13767985 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,12379214 0,1376133 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,12620455 0,14022728 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,12620455 0,14015957 ! sensory perception of smell GO:0007608 61 49 0,000 0,12620455 0,14009193 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,12620455 0,14002435 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,12620455 0,13995683 ! RNA elongation GO:0006354 62 49 0,000 0,12620455 0,13988938 ! germ cell development GO:0007281 68 49 0,000 0,12620455 0,139822 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,12620455 0,13975468 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,12620455 0,13968743 ! cartilage development GO:0051216 70 49 0,000 0,12620455 0,13962024 ! maintenance of location GO:0051235 84 49 0,000 0,12620455 0,13955311 ! regulation of actin filament length GO:0030832 72 50 0,000 0,12861046 0,14214515 ! ear development GO:0043583 72 50 0,000 0,12861046 0,14207688 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,12861046 0,14200867 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,12861046 0,14194053 ! positive regulation of growth GO:0045927 67 50 0,000 0,12861046 0,14187245 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,12861046 0,14180444 ! proton transport GO:0015992 75 50 0,000 0,12861046 0,14173649 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,12861046 0,14166861 ! positive regulation of secretion GO:0051047 71 51 0,000 0,13100988 0,14424257 ! hydrogen transport GO:0006818 77 51 0,000 0,13100988 0,14417355 ! muscle fiber development GO:0048747 74 51 0,000 0,13100988 0,1441046 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,13100988 0,14403572 ! adult behavior GO:0030534 80 51 0,000 0,13100988 0,1439669 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,13100988 0,14389815 ! transition metal ion transport GO:0000041 74 52 0,000 0,13340283 0,14645657 ! regulation of cellular component size GO:0032535 74 52 0,000 0,13340283 0,14638669 ! aging GO:0007568 79 52 0,000 0,13340283 0,14631689 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,13340283 0,14624715 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,13340283 0,14617747 ! establishment of organelle localization GO:0051656 85 52 0,000 0,13340283 0,14610786 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,13578933 0,14865086 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,13578933 0,14858014 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,13578933 0,14850949 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,13578933 0,14843891 ! single fertilization GO:0007338 59 53 0,000 0,13578933 0,14836839 ! cell projection assembly GO:0030031 76 53 0,000 0,13578933 0,14829794 ! amino acid transport GO:0006865 84 54 0,000 0,13816939 0,15082563 ! glucose catabolic process GO:0006007 66 54 0,000 0,13816939 0,15075408 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,13816939 0,1506826 ! DNA catabolic process GO:0006308 67 54 0,000 0,13816939 0,15061119 ! detection of external stimulus GO:0009581 66 54 0,000 0,13816939 0,15053984 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,13816939 0,15046856 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,13816939 0,15039735 ! exocytosis GO:0006887 74 55 0,000 0,14054304 0,1529087 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,14054304 0,1528364 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,14054304 0,15276417 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,14291028 0,15526388 ! carbohydrate transport GO:0008643 74 57 0,000 0,14527114 0,1577543 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,14527114 0,15767986 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,14527114 0,15760548 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,14527114 0,15753117 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,14527114 0,15745693 ! camera-type eye development GO:0043010 88 57 0,000 0,14527114 0,15738277 ! secondary metabolic process GO:0019748 84 57 0,000 0,14527114 0,15730867 ! developmental maturation GO:0021700 75 57 0,000 0,14527114 0,15723464 ! gonad development GO:0008406 79 57 0,000 0,14527114 0,15716068 ! viral reproductive process GO:0022415 87 58 0,000 0,14762563 0,15963279 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,14762563 0,15955777 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,14762563 0,15948283 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,14762563 0,15940795 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,14997377 0,16186751 ! actin filament organization GO:0007015 95 59 0,000 0,14997377 0,16179159 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,14997377 0,16171573 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,14997377 0,16163995 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,15231557 0,16408703 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,15231557 0,16401021 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,15231557 0,16393346 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,15231557 0,16385679 ! regulation of heart contraction GO:0008016 91 60 0,000 0,15231557 0,16378018 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,15231557 0,16370365 ! fertilization GO:0009566 68 60 0,000 0,15231557 0,16362719 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,15465106 0,16605856 ! meiosis GO:0007126 96 61 0,000 0,15465106 0,16598107 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,15465106 0,16590365 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,15465106 0,16582631 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,15465106 0,16574904 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,15465106 0,16567184 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,15465106 0,16559471 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,15465106 0,16551765 ! amine catabolic process GO:0009310 90 62 0,000 0,15698024 0,16793235 ! neurotransmitter transport GO:0006836 81 62 0,000 0,15698024 0,16785428 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,15698024 0,16777628 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,15698024 0,16769835 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,15698024 0,1676205 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,15698024 0,16754272 ! meiotic cell cycle GO:0051321 97 62 0,000 0,15698024 0,16746501 ! organelle localization GO:0051640 96 62 0,000 0,15698024 0,16738737 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,15930314 0,16978556 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,15930314 0,16970692 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,15930314 0,16962835 ! viral reproduction GO:0016032 92 63 0,000 0,15930314 0,16954985 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,16161978 0,17193593 ! negative regulation of cell size GO:0045792 108 64 0,000 0,16161978 0,17185644 ! appendage morphogenesis GO:0035107 93 64 0,000 0,16161978 0,17177703 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,16161978 0,17169769 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,16161978 0,17161842 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,16161978 0,17153922 ! hexose catabolic process GO:0019320 82 64 0,000 0,16161978 0,1714601 ! adaptive immune response GO:0002250 94 64 0,000 0,16161978 0,17138105 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,16393016 0,17375086 ! appendage development GO:0048736 94 65 0,000 0,16393016 0,17367083 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,16393016 0,17359087 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,16393016 0,17351099 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,16393016 0,17343117 ! defense response to bacterium GO:0042742 73 65 0,000 0,16393016 0,17335143 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,16623431 0,17570722 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,16623431 0,17562651 ! antigen processing and presentation GO:0019882 96 66 0,000 0,16623431 0,17554587 ! axon guidance GO:0007411 99 66 0,000 0,16623431 0,17546531 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,16623431 0,17538482 ! acute inflammatory response GO:0002526 92 68 0,000 0,17082397 0,18014449 ! learning or memory GO:0007611 123 68 0,000 0,17082397 0,18006193 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,17082397 0,17997944 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,17082397 0,17989704 ! rhythmic process GO:0048511 105 68 0,000 0,17082397 0,1798147 ! inorganic anion transport GO:0015698 93 68 0,000 0,17082397 0,17973245 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,17310951 0,1820539 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,17310951 0,18197069 ! response to drug GO:0042493 108 69 0,000 0,17310951 0,18188756 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,17310951 0,18180451 ! response to metal ion GO:0010038 103 70 0,000 0,17538889 0,1841143 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,17538889 0,18403031 ! humoral immune response GO:0006959 86 70 0,000 0,17538889 0,18394639 ! eye development GO:0001654 111 70 0,000 0,17538889 0,18386255 ! amine transport GO:0015837 101 70 0,000 0,17538889 0,18377879 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,17538889 0,1836951 ! regulation of catabolic process GO:0009894 106 70 0,000 0,17538889 0,18361149 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,17766211 0,18590666 ! muscle cell differentiation GO:0042692 104 71 0,000 0,17766211 0,18582212 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,17766211 0,18573766 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,17766211 0,18565327 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,17766211 0,18556896 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,17766211 0,18548472 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,17992919 0,1877664 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,17992919 0,18768124 ! negative regulation of transport GO:0051051 116 73 0,000 0,18219016 0,18995347 ! regulation of blood pressure GO:0008217 107 73 0,000 0,18219016 0,1898674 ! mitochondrion organization GO:0007005 104 73 0,000 0,18219016 0,18978141 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,18219016 0,1896955 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,18219016 0,18960967 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,18444502 0,19186954 ! digestion GO:0007586 97 74 0,000 0,18444502 0,19178279 ! protein import into nucleus GO:0006606 118 74 0,000 0,18444502 0,19169613 ! blood coagulation GO:0007596 116 75 0,000 0,18669379 0,19394567 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,18669379 0,19385811 ! negative regulation of growth GO:0045926 123 75 0,000 0,18669379 0,19377063 ! response to nutrient GO:0007584 104 75 0,000 0,18669379 0,19368323 ! regulation of ligase activity GO:0051340 114 75 0,000 0,18669379 0,19359591 ! nuclear import GO:0051170 121 75 0,000 0,18669379 0,19350866 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,18669379 0,1934215 ! amine biosynthetic process GO:0009309 97 76 0,000 0,18893649 0,19565688 ! tRNA metabolic process GO:0006399 95 76 0,000 0,18893649 0,19556883 ! response to unfolded protein GO:0006986 99 76 0,000 0,18893649 0,19548085 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,19117314 0,19770603 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,19117314 0,19761718 ! regulation of DNA binding GO:0051101 119 77 0,000 0,19117314 0,1975284 ! protein ubiquitination GO:0016567 125 77 0,000 0,19117314 0,1974397 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,19117314 0,19735108 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,19117314 0,19726255 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,19117314 0,19717409 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,19340374 0,1993853 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,19340374 0,19929597 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,19340374 0,19920672 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,19562832 0,20140785 ! cellular respiration GO:0045333 107 79 0,000 0,19562832 0,20131774 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,19562832 0,2012277 ! regulation of lyase activity GO:0051339 133 79 0,000 0,19562832 0,20113775 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,19562832 0,20104788 ! chromatin assembly GO:0031497 102 80 0,000 0,1978469 0,2032371 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,1978469 0,20314637 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,1978469 0,20305572 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,1978469 0,20296515 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,20005948 0,20514347 ! hemostasis GO:0007599 125 81 0,000 0,20005948 0,20505205 ! mRNA transport GO:0051028 121 81 0,000 0,20005948 0,20496072 ! response to protein stimulus GO:0051789 111 81 0,000 0,20005948 0,20486946 ! regulation of neurological system process GO:0031644 122 81 0,000 0,20005948 0,20477828 ! vitamin metabolic process GO:0006766 103 81 0,000 0,20005948 0,20468719 ! detection of stimulus GO:0051606 108 82 0,000 0,20226609 0,20685282 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,20446673 0,20901044 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,20446673 0,20891758 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,20446673 0,20882481 ! regulation of defense response GO:0031347 117 84 0,000 0,20666143 0,21097261 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,20666143 0,21087901 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,20666143 0,2107855 ! sterol metabolic process GO:0016125 120 84 0,000 0,20666143 0,21069206 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,2088502 0,21282918 ! rRNA metabolic process GO:0016072 107 85 0,000 0,2088502 0,21273493 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,2088502 0,21264076 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,2088502 0,21254667 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,21103306 0,21467317 ! cell cycle arrest GO:0007050 150 86 0,000 0,21103306 0,21457827 ! nucleosome organization GO:0034728 114 87 0,000 0,21321002 0,216696 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,21321002 0,21660029 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,21321002 0,21650466 ! female pregnancy GO:0007565 130 87 0,000 0,21321002 0,21640911 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,21321002 0,21631365 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,2153811 0,21841999 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,2153811 0,21832373 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,2153811 0,21822755 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,2153811 0,21813146 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,2153811 0,21803545 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,21754632 0,22013046 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,21754632 0,22003365 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,21970568 0,22212002 ! hormone metabolic process GO:0042445 121 90 0,000 0,21970568 0,22202243 ! RNA localization GO:0006403 135 91 0,000 0,2218592 0,2241002 ! ATP metabolic process GO:0046034 137 91 0,000 0,2218592 0,22400183 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,22400691 0,22607104 ! DNA recombination GO:0006310 146 92 0,000 0,22400691 0,22597188 ! sulfur metabolic process GO:0006790 118 92 0,000 0,22400691 0,22587281 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,22614881 0,22793263 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,22614881 0,22783279 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,22614881 0,22773304 ! electron transport chain GO:0022900 123 94 0,000 0,22828492 0,22978351 ! response to oxidative stress GO:0006979 141 94 0,000 0,22828492 0,22968299 ! regulation of binding GO:0051098 151 95 0,000 0,23041526 0,23172501 ! carboxylic acid transport GO:0046942 147 95 0,000 0,23041526 0,23162373 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,23253984 0,23365733 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,23253984 0,2335553 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,23253984 0,23345335 ! protein maturation GO:0051604 129 96 0,000 0,23253984 0,2333515 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,23465868 0,23537504 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,23465868 0,23527243 ! protein import GO:0017038 156 99 0,000 0,23887918 0,23939961 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,24098088 0,2414007 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,24098088 0,24129561 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,24098088 0,24119061 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,24098088 0,2410857 ! protein localization in organelle GO:0033365 161 100 0,000 0,24098088 0,24098088