pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/605-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! interphase of mitotic cell cycle GO:0051329 156 86 7,000 2,051E-07 4,718E-04 ! interphase GO:0051325 159 88 7,000 2,455E-07 2,823E-04 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 5,000 6,385E-07 4,895E-04 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 3,000 2,513E-06 1,445E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 1,003E-05 4,615E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 2,042E-05 7,827E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 2,042E-05 6,709E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 3,36E-05 9,661E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 4,329E-05 0,01106239 ! regulation of chemokine biosynthetic process GO:0045073 12 10 2,000 4,329E-05 9,956E-03 ! actin filament organization GO:0007015 95 59 4,000 6,837E-05 0,01429506 ! regulation of chemokine production GO:0032642 17 13 2,000 1,015E-04 0,01946084 ! G1 phase of mitotic cell cycle GO:0000080 23 14 2,000 1,285E-04 0,02274182 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 1,285E-04 0,02111741 ! activation of protein kinase activity GO:0032147 102 69 4,000 1,448E-04 0,02220857 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 2,000 1,598E-04 0,02297469 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 1,598E-04 0,02162324 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 3,000 1,794E-04 0,02292712 ! G1 phase GO:0051318 27 16 2,000 1,957E-04 0,02368561 ! actin polymerization or depolymerization GO:0008154 31 17 2,000 2,363E-04 0,02717826 ! signal complex assembly GO:0007172 29 17 2,000 2,363E-04 0,02588406 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 2,821E-04 0,02949195 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 2,88E-04 0,02879551 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 3,143E-04 0,03011877 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 3,332E-04 0,03065589 ! regulation of postsynaptic membrane potential GO:0060078 30 19 2,000 3,332E-04 0,02947681 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 3,332E-04 0,02838508 ! apoptotic nuclear changes GO:0030262 24 19 2,000 3,332E-04 0,02737133 ! response to UV GO:0009411 75 46 3,000 3,423E-04 0,0271473 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 3,72E-04 0,02852338 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 4,525E-04 0,03357456 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 4,525E-04 0,03252536 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 4,525E-04 0,03153974 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 4,525E-04 0,0306121 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 1,000 5,162E-04 0,03391985 ! regulation of interferon-beta production GO:0032648 5 5 1,000 5,162E-04 0,03297764 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 5,162E-04 0,03208635 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 1,000 5,162E-04 0,03124197 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 5,162E-04 0,0304409 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 5,162E-04 0,02967987 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 5,162E-04 0,02895597 ! valine metabolic process GO:0006573 8 5 1,000 5,162E-04 0,02826655 ! early endosome to late endosome transport GO:0045022 11 5 1,000 5,162E-04 0,02760918 ! centrosome duplication GO:0051298 5 5 1,000 5,162E-04 0,0269817 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 5,162E-04 0,02638211 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 5,212E-04 0,02606031 ! membrane depolarization GO:0051899 35 22 2,000 5,212E-04 0,02550584 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 5,962E-04 0,02856874 ! DNA catabolic process GO:0006308 67 54 3,000 6,343E-04 0,02977419 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 6,778E-04 0,03117827 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 6,778E-04 0,03056693 ! neurotransmitter secretion GO:0007269 32 24 2,000 6,778E-04 0,0299791 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 7,661E-04 0,03324773 ! hyperosmotic response GO:0006972 8 6 1,000 7,706E-04 0,03282068 ! neuron apoptosis GO:0051402 8 6 1,000 7,706E-04 0,03222394 ! interaction with symbiont GO:0051702 8 6 1,000 7,706E-04 0,03164852 ! positive regulation of cytokine production during immune response GO:0002720 8 6 1,000 7,706E-04 0,03109328 ! response to exogenous dsRNA GO:0043330 8 6 1,000 7,706E-04 0,03055719 ! negative regulation of B cell activation GO:0050869 9 6 1,000 7,706E-04 0,03003927 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 7,791E-04 0,02986615 ! negative regulation of kinase activity GO:0033673 100 58 3,000 8,322E-04 0,0313768 ! negative regulation of transcription regulator activity GO:0090048 47 27 2,000 9,641E-04 0,03576378 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 2,000 9,641E-04 0,0351961 ! negative regulation of transferase activity GO:0051348 105 61 3,000 1,007E-03 0,03617348 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 3,000 1,007E-03 0,03561697 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 3,000 1,07E-03 0,03728772 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,074E-03 0,03685733 ! regulation of interferon-alpha production GO:0032647 7 7 1,000 1,074E-03 0,03631531 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,074E-03 0,035789 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,074E-03 0,03527773 ! negative regulation of muscle cell differentiation GO:0051148 9 7 1,000 1,074E-03 0,03478086 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 1,000 1,074E-03 0,03429779 ! Rac protein signal transduction GO:0016601 7 7 1,000 1,074E-03 0,03382796 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 1,000 1,074E-03 0,03337082 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 1,000 1,074E-03 0,03292588 ! negative regulation of osteoclast differentiation GO:0045671 10 7 1,000 1,074E-03 0,03249264 ! regulation of B cell activation GO:0050864 42 28 2,000 1,074E-03 0,03208213 ! regulation of transcription factor activity GO:0051090 97 63 3,000 1,136E-03 0,03350271 GO:0090046|regulation of transcription regulator activity, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 3,000 1,277E-03 0,03718038 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 3,000 1,277E-03 0,03671563 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,425E-03 0,04045599 ! succinate metabolic process GO:0006105 14 8 1,000 1,425E-03 0,03996262 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,425E-03 0,03948114 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,425E-03 0,03901113 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 1,000 1,425E-03 0,03855217 ! L-phenylalanine metabolic process GO:0006558 8 8 1,000 1,425E-03 0,03810389 GO:0006559|L-phenylalanine catabolic process, ! regulation of type I interferon production GO:0032479 8 8 1,000 1,425E-03 0,03766592 ! Schwann cell differentiation GO:0014037 17 8 1,000 1,425E-03 0,0372379 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,425E-03 0,03681949 ! negative regulation of cytokine secretion GO:0050710 12 8 1,000 1,425E-03 0,03641039 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,425E-03 0,03601027 ! lamellipodium assembly GO:0030032 9 8 1,000 1,425E-03 0,03561886 ! mitochondrion localization GO:0051646 12 8 1,000 1,425E-03 0,03523586 ! negative regulation of secretion GO:0051048 49 31 2,000 1,451E-03 0,03549103 ! response to mechanical stimulus GO:0009612 43 31 2,000 1,451E-03 0,03511744 ! calcium-mediated signaling GO:0019722 50 32 2,000 1,592E-03 0,03814441 ! positive regulation of ligase activity GO:0051351 99 69 3,000 1,595E-03 0,03781245 ! nucleus organization GO:0006997 49 33 2,000 1,742E-03 0,04088587 ! negative regulation of DNA binding GO:0043392 54 33 2,000 1,742E-03 0,04047289 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,742E-03 0,04006816 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 1,772E-03 0,04036298 ! regulation of activated T cell proliferation GO:0046006 15 9 1,000 1,823E-03 0,04110964 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,823E-03 0,04071052 GO:0006600|creatine metabolic process, ! receptor clustering GO:0043113 15 9 1,000 1,823E-03 0,04031907 ! oocyte differentiation GO:0009994 12 9 1,000 1,823E-03 0,03993508 GO:0048599|oocyte development, ! positive regulation of protein polymerization GO:0032273 15 9 1,000 1,823E-03 0,03955833 ! localization within membrane GO:0051668 15 9 1,000 1,823E-03 0,03918863 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 1,901E-03 0,04047605 ! negative regulation of transport GO:0051051 116 73 3,000 1,964E-03 0,04143218 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 2,064E-03 0,04316058 ! positive regulation of lymphocyte activation GO:0051251 108 74 3,000 2,064E-03 0,04277175 ! keratinocyte differentiation GO:0030216 47 35 2,000 2,068E-03 0,04246469 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 2,068E-03 0,04208889 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of ligase activity GO:0051340 114 75 3,000 2,168E-03 0,04374824 ! negative regulation of binding GO:0051100 58 36 2,000 2,244E-03 0,04487903 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,268E-03 0,04497059 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 1,000 2,268E-03 0,04458623 ! response to dsRNA GO:0043331 18 10 1,000 2,268E-03 0,04420838 ! cranial nerve development GO:0021545 12 10 1,000 2,268E-03 0,04383688 ! DNA methylation GO:0006306 15 10 1,000 2,268E-03 0,04347157 GO:0006305|DNA alkylation, ! positive regulation of JNK cascade GO:0046330 14 10 1,000 2,268E-03 0,0431123 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 2,268E-03 0,04275892 ! regulation of DNA binding GO:0051101 119 77 3,000 2,388E-03 0,04464531 ! gliogenesis GO:0042063 71 38 2,000 2,623E-03 0,04866019 ! regulation of T cell proliferation GO:0042129 58 38 2,000 2,623E-03 0,04827091 ! maintenance of location in cell GO:0051651 69 38 2,000 2,623E-03 0,04788781 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 3,000 2,744E-03 0,04969769 GO:0010498|proteasomal protein catabolic process, ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 2,759E-03 0,04957477 ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,759E-03 0,04919047 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 2,759E-03 0,04881208 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 2,759E-03 0,04843947 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 2,759E-03 0,04807251 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 1,000 2,759E-03 0,04771106 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 2,759E-03 0,04735501 ! T cell homeostasis GO:0043029 20 11 1,000 2,759E-03 0,04700423 ! regulation of osteoclast differentiation GO:0045670 15 11 1,000 2,759E-03 0,04665861 ! aromatic amino acid family catabolic process GO:0009074 13 11 1,000 2,759E-03 0,04631803 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 2,759E-03 0,0459824 GO:0042130|negative regulation of T cell proliferation, ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 2,827E-03 0,0467791 ! positive regulation of cell activation GO:0050867 120 81 3,000 2,871E-03 0,04716196 GO:0002696|positive regulation of leukocyte activation, ! epidermal cell differentiation GO:0009913 53 40 2,000 3,04E-03 0,04959246 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 3,04E-03 0,04924322 ! tyrosine metabolic process GO:0006570 14 12 1,000 3,295E-03 0,05299696 ! negative regulation of protein secretion GO:0050709 20 12 1,000 3,295E-03 0,05262893 ! transcription initiation GO:0006352 118 85 3,000 3,417E-03 0,05419925 ! cellular component disassembly GO:0022411 64 42 2,000 3,496E-03 0,05506667 ! cell cycle arrest GO:0007050 150 86 3,000 3,564E-03 0,05575924 ! response to insulin stimulus GO:0032868 63 43 2,000 3,738E-03 0,05808989 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 3,876E-03 0,05982568 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 1,000 3,876E-03 0,05942684 ! endocrine pancreas development GO:0031018 19 13 1,000 3,876E-03 0,05903329 ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 3,876E-03 0,05864491 ! regulation of cytokine production during immune response GO:0002718 18 13 1,000 3,876E-03 0,05826161 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 3,876E-03 0,05788329 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 3,876E-03 0,05750985 ! lymphocyte homeostasis GO:0002260 24 13 1,000 3,876E-03 0,0571412 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 2,000 3,99E-03 0,05845805 ! regulation of T cell activation GO:0050863 128 89 3,000 4,03E-03 0,05866254 ! cell maturation GO:0048469 60 45 2,000 4,253E-03 0,06152105 ! neuron maturation GO:0042551 21 14 1,000 4,5E-03 0,06469015 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,5E-03 0,06428835 ! gene silencing by RNA GO:0031047 20 14 1,000 4,5E-03 0,0638915 ! cellular response to starvation GO:0009267 21 14 1,000 4,5E-03 0,06349953 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 4,5E-03 0,06311234 ! cell killing GO:0001906 20 14 1,000 4,5E-03 0,06272984 ! regulation of binding GO:0051098 151 95 3,000 5,082E-03 0,07041942 ! lipid phosphorylation GO:0046834 23 15 1,000 5,168E-03 0,07117511 ! regulation of muscle cell differentiation GO:0051147 24 15 1,000 5,168E-03 0,07075145 ! centrosome cycle GO:0007098 16 15 1,000 5,168E-03 0,0703328 ! regulation of survival gene product expression GO:0045884 20 15 1,000 5,168E-03 0,06991908 ! response to osmotic stress GO:0006970 22 15 1,000 5,168E-03 0,06951019 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 5,168E-03 0,06910607 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 5,168E-03 0,06870661 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 5,168E-03 0,06831174 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! response to light stimulus GO:0009416 153 96 3,000 5,274E-03 0,06931697 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 5,407E-03 0,07065975 ! maintenance of location GO:0051235 84 49 2,000 5,407E-03 0,07026054 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 3,000 5,471E-03 0,07068718 ! skeletal muscle fiber development GO:0048741 73 50 2,000 5,722E-03 0,07352269 ! calcium ion transport GO:0006816 167 99 3,000 5,878E-03 0,07510832 ! oogenesis GO:0048477 23 16 1,000 5,878E-03 0,07469607 ! detection of biotic stimulus GO:0009595 19 16 1,000 5,878E-03 0,07428565 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 5,878E-03 0,07387972 ! nerve development GO:0021675 18 16 1,000 5,878E-03 0,0734782 ! muscle fiber development GO:0048747 74 51 2,000 6,048E-03 0,07518825 ! divalent metal ion transport GO:0070838 171 100 3,000 6,089E-03 0,07529606 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 6,631E-03 0,08155176 ! memory GO:0007613 25 17 1,000 6,631E-03 0,08111797 ! inactivation of MAPK activity GO:0000188 27 17 1,000 6,631E-03 0,08068877 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 6,631E-03 0,0802641 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 6,631E-03 0,07984387 ! aromatic compound catabolic process GO:0019439 22 17 1,000 6,631E-03 0,07942801 ! negative regulation of coagulation GO:0050819 23 17 1,000 6,631E-03 0,07901647 ! regulation of neurotransmitter levels GO:0001505 73 53 2,000 6,732E-03 0,0798127 ! detection of external stimulus GO:0009581 66 54 2,000 7,091E-03 0,08363409 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 7,424E-03 0,08711912 ! pancreas development GO:0031016 26 18 1,000 7,424E-03 0,08667689 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 7,424E-03 0,08623913 ! peptide cross-linking GO:0018149 31 18 1,000 7,424E-03 0,08580577 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 7,424E-03 0,08537674 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 7,424E-03 0,08495198 ! cellular response to nutrient levels GO:0031669 27 18 1,000 7,424E-03 0,08453142 ! regulation of cytokine secretion GO:0050707 26 18 1,000 7,424E-03 0,08411501 ! negative regulation of T cell activation GO:0050868 25 18 1,000 7,424E-03 0,08370269 ! exocytosis GO:0006887 74 55 2,000 7,461E-03 0,08370374 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 8,234E-03 0,09193269 ! developmental maturation GO:0021700 75 57 2,000 8,234E-03 0,09148857 ! response to alkaloid GO:0043279 32 19 1,000 8,258E-03 0,09131754 ! sex determination GO:0007530 29 19 1,000 8,258E-03 0,09088061 ! regulation of interleukin-2 production GO:0032663 31 19 1,000 8,258E-03 0,09044785 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 8,258E-03 0,09001918 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 1,000 8,258E-03 0,08959457 ! aromatic amino acid family metabolic process GO:0009072 24 19 1,000 8,258E-03 0,08917393 ! protein stabilization GO:0050821 26 19 1,000 8,258E-03 0,08875723 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 8,258E-03 0,08834441 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 8,258E-03 0,08793541 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 8,258E-03 0,08753017 ! response to starvation GO:0042594 30 19 1,000 8,258E-03 0,08712866 ! response to lipopolysaccharide GO:0032496 26 19 1,000 8,258E-03 0,08673081 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 8,258E-03 0,08633658 ! regulation of cytokine biosynthetic process GO:0042035 76 58 2,000 8,638E-03 0,08989467 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 8,638E-03 0,08948974 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 9,133E-03 0,09419213 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 9,133E-03 0,09377163 ! DNA modification GO:0006304 28 20 1,000 9,133E-03 0,09335487 ! positive regulation of B cell activation GO:0050871 31 20 1,000 9,133E-03 0,09294179 ! actin filament-based movement GO:0030048 34 20 1,000 9,133E-03 0,09253236 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 2,000 9,48E-03 0,09562725 ! regulation of homeostatic process GO:0032844 105 60 2,000 9,48E-03 0,09520966 ! negative regulation of ligase activity GO:0051352 91 61 2,000 9,918E-03 0,0991783 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01004623 0,10002737 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 0,01004623 0,09959622 ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 0,01004623 0,09916877 ! neurotransmitter transport GO:0006836 81 62 2,000 0,01036772 0,10190494 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 0,0108293 0,10598886 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,0108293 0,10553976 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01099873 0,10673872 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01099873 0,10629024 ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01099873 0,10584551 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 0,01099873 0,10540449 GO:0010810|regulation of cell-substrate adhesion, ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01099873 0,10496713 ! positive regulation of T cell activation GO:0050870 94 65 2,000 0,01178772 0,11203206 ! protein oligomerization GO:0051259 100 65 2,000 0,01178772 0,11157102 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01198944 0,11301526 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01198944 0,11255397 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01198944 0,11209643 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01198944 0,1116426 ! interaction with host GO:0051701 37 23 1,000 0,01198944 0,11119243 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01198944 0,11074588 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 0,01198944 0,11030289 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01198944 0,10986344 ! response to molecule of bacterial origin GO:0002237 30 23 1,000 0,01198944 0,10942747 ! regulation of interferon-gamma production GO:0032649 30 24 1,000 0,01301778 0,11834343 ! receptor metabolic process GO:0043112 37 24 1,000 0,01301778 0,11787751 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 0,01301778 0,11741524 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,01301778 0,11695659 ! acute inflammatory response GO:0002526 92 68 2,000 0,01331424 0,11915464 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 0,01408314 0,12554734 GO:0045936|negative regulation of phosphate metabolic process, ! iron ion homeostasis GO:0055072 39 25 1,000 0,01408314 0,1250626 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,01408314 0,12458159 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,01408314 0,12410427 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01408314 0,12363059 ! positive regulation of phosphorylation GO:0042327 102 70 2,000 0,01439164 0,12585848 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 2,000 0,01439164 0,12538174 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01518494 0,13179382 ! regulation of coagulation GO:0050818 39 26 1,000 0,01518494 0,13129835 ! regulation of synaptic transmission GO:0050804 109 72 2,000 0,01551716 0,1336684 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 2,000 0,01551716 0,13316964 GO:0045937|positive regulation of phosphate metabolic process, ! mitochondrion organization GO:0007005 104 73 2,000 0,01609803 0,13764113 ! acute-phase response GO:0006953 42 27 1,000 0,01632261 0,13904445 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,01632261 0,13853137 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01632261 0,13802207 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01632261 0,13751649 ! gene silencing GO:0016458 41 27 1,000 0,01632261 0,13701461 ! protein import into nucleus GO:0006606 118 74 2,000 0,01669101 0,13959751 ! nuclear import GO:0051170 121 75 2,000 0,01729612 0,1441343 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01749558 0,14527012 ! complement activation, classical pathway GO:0006958 36 28 1,000 0,01749558 0,14474757 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01749558 0,14422876 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 0,01749558 0,14371365 ! regulation of protein transport GO:0051223 114 76 2,000 0,01791337 0,14662193 GO:0070201|regulation of establishment of protein localization, ! cholesterol metabolic process GO:0008203 109 77 2,000 0,0185428 0,1512356 ! regulation of transmission of nerve impulse GO:0051969 116 77 2,000 0,0185428 0,1507012 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,01870327 0,15147017 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01870327 0,15093869 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 0,01994514 0,16039801 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 0,01994514 0,15983913 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,01994514 0,15928413 ! positive regulation of immune effector process GO:0002699 40 30 1,000 0,01994514 0,15873298 ! protein localization in nucleus GO:0034504 133 80 2,000 0,02050421 0,16261956 ! regulation of neurological system process GO:0031644 122 81 2,000 0,02118242 0,16742116 ! glial cell differentiation GO:0010001 55 31 1,000 0,02122064 0,16714885 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,02122064 0,16657837 ! detection of stimulus GO:0051606 108 82 2,000 0,02187284 0,17111407 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,0225292 0,17565142 ! peripheral nervous system development GO:0007422 53 32 1,000 0,0225292 0,17505801 ! regulation of protein stability GO:0031647 48 32 1,000 0,0225292 0,17446859 ! cytokine production GO:0001816 44 32 1,000 0,0225292 0,17388312 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,0225292 0,17330157 ! regulation of cell adhesion GO:0030155 159 83 2,000 0,02257548 0,17307871 ! sterol metabolic process GO:0016125 120 84 2,000 0,02329034 0,17796609 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,02387031 0,18179374 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,02387031 0,18119376 ! ear morphogenesis GO:0042471 42 33 1,000 0,02387031 0,18059773 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 0,02401742 0,18111498 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 0,02401742 0,1805231 ! regulation of protein localization GO:0032880 132 85 2,000 0,02401742 0,17993508 ! regulation of membrane potential GO:0042391 128 85 2,000 0,02401742 0,17935087 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,02524341 0,18789596 ! female gamete generation GO:0007292 43 34 1,000 0,02524341 0,18728985 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,02550821 0,18864591 GO:0060538|skeletal muscle organ development, ! protein processing GO:0016485 114 88 2,000 0,0262719 0,19367108 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,02664799 0,19581593 ! maintenance of protein location GO:0045185 65 35 1,000 0,02664799 0,19519231 ! protein homooligomerization GO:0051260 52 35 1,000 0,02664799 0,19457266 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,02808353 0,20440541 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,02808353 0,2037606 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,02808353 0,20311984 ! positive regulation of immune response GO:0050778 121 92 2,000 0,02944845 0,21232428 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,02954949 0,21238699 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 0,02954949 0,21172534 GO:0006956|complement activation, ! regulation of protein secretion GO:0050708 51 37 1,000 0,02954949 0,21106781 ! peptidyl-amino acid modification GO:0018193 147 93 2,000 0,03027296 0,21556598 ! pigmentation GO:0043473 74 38 1,000 0,03104539 0,22038392 ! response to oxidative stress GO:0006979 141 94 2,000 0,03110958 0,22016011 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,0325707 0,22979328 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,0325707 0,22909055 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,0325707 0,22839211 ! protein maturation GO:0051604 129 96 2,000 0,03281907 0,22943424 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,03412494 0,23784046 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03412494 0,23712191 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,03412494 0,23640769 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,03412494 0,23569775 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,03412494 0,23499207 ! protein import GO:0017038 156 99 2,000 0,03547357 0,24354991 ! endosome transport GO:0016197 71 41 1,000 0,0357076 0,24442701 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,0357076 0,24370171 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,0357076 0,2429807 ! biopolymer methylation GO:0043414 62 41 1,000 0,0357076 0,24226394 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,0357076 0,2415514 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03580319 0,24148776 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03580319 0,24078166 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03580319 0,24007967 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03580319 0,23938176 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03580319 0,2386879 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03580319 0,23799805 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03580319 0,23731218 ! sleep GO:0030431 11 5 0,000 0,03580319 0,23663025 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03580319 0,23595223 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03580319 0,23527808 ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03580319 0,23460777 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03580319 0,23394127 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03580319 0,23327855 ! tongue development GO:0043586 6 5 0,000 0,03580319 0,23261957 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03580319 0,2319643 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03580319 0,23131272 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03580319 0,23066478 ! cobalt ion transport GO:0006824 9 5 0,000 0,03580319 0,23002047 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03580319 0,22937974 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03580319 0,22874257 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03580319 0,22810894 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03580319 0,2274788 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03580319 0,22685214 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03580319 0,22622892 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03580319 0,22560911 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03580319 0,2249927 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03580319 0,22437964 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03580319 0,22376991 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03580319 0,22316349 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,03580319 0,22256034 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03580319 0,22196045 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03580319 0,22136378 ! malate metabolic process GO:0006108 7 5 0,000 0,03580319 0,22077031 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03580319 0,22018002 ! behavioral response to pain GO:0048266 7 5 0,000 0,03580319 0,21959287 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03580319 0,21900885 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03580319 0,21842792 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03580319 0,21785007 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03580319 0,21727527 ! mating behavior GO:0007617 6 5 0,000 0,03580319 0,21670349 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03580319 0,21613472 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03580319 0,21556892 ! rhythmic behavior GO:0007622 12 5 0,000 0,03580319 0,21500608 ! copulation GO:0007620 7 5 0,000 0,03580319 0,21444616 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03580319 0,21388916 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03580319 0,21333504 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03580319 0,21278379 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03580319 0,21223538 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03580319 0,21168979 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03580319 0,21114699 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03580319 0,21060697 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03580319 0,21006971 ! response to protozoan GO:0001562 9 5 0,000 0,03580319 0,20953518 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03580319 0,20900337 ! lymph vessel development GO:0001945 7 5 0,000 0,03580319 0,20847424 ! endochondral ossification GO:0001958 12 5 0,000 0,03580319 0,20794779 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03580319 0,207424 ! parathyroid gland development GO:0060017 8 5 0,000 0,03580319 0,20690283 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03580319 0,20638428 ! anagen GO:0042640 6 5 0,000 0,03580319 0,20586832 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03580319 0,20535493 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03580319 0,2048441 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03580319 0,2043358 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03580319 0,20383002 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03580319 0,20332673 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03580319 0,20282593 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03580319 0,20232758 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03580319 0,20183168 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03580319 0,20133821 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03580319 0,20084714 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03580319 0,20035846 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03580319 0,19987215 ! ovulation GO:0030728 6 5 0,000 0,03580319 0,1993882 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03580319 0,19890659 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03580319 0,19842729 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,03580319 0,1979503 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03580319 0,1974756 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03580319 0,19700317 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03580319 0,196533 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03580319 0,19606506 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03580319 0,19559935 ! polyol catabolic process GO:0046174 7 5 0,000 0,03580319 0,19513585 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03580319 0,19467453 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03580319 0,19421539 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03580319 0,19375842 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03580319 0,19330358 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03580319 0,19285088 ! urea metabolic process GO:0019627 6 5 0,000 0,03580319 0,1924003 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03580319 0,19195181 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03580319 0,19150541 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03580319 0,19106108 ! neutrophil activation GO:0042119 5 5 0,000 0,03580319 0,19061881 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03580319 0,19017858 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03580319 0,18974038 ! response to food GO:0032094 5 5 0,000 0,03580319 0,1893042 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03580319 0,18887002 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03580319 0,18843782 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03580319 0,1880076 ! forebrain neuron development GO:0021884 7 5 0,000 0,03580319 0,18757933 ! melanosome organization GO:0032438 7 5 0,000 0,03580319 0,18715302 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03580319 0,18672863 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03580319 0,18630617 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03580319 0,18588561 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03580319 0,18546695 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03580319 0,18505017 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03580319 0,18463526 ! nucleoside transport GO:0015858 6 5 0,000 0,03580319 0,18422221 ! nucleoside salvage GO:0043174 7 5 0,000 0,03580319 0,183811 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03580319 0,18340162 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03580319 0,18299406 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03580319 0,18258831 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03580319 0,18218435 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03580319 0,18178218 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03580319 0,18138178 ! depyrimidination GO:0045008 8 5 0,000 0,03580319 0,18098314 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03580319 0,18058624 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03580319 0,18019109 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03580319 0,17979766 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03580319 0,17940594 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03580319 0,17901593 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03580319 0,17862761 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03580319 0,17824097 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03580319 0,177856 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03580319 0,17747269 ! monocyte differentiation GO:0030224 8 5 0,000 0,03580319 0,17709103 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03580319 0,176711 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03580319 0,17633261 ! response to UV-C GO:0010225 6 5 0,000 0,03580319 0,17595583 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03580319 0,17558065 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03580319 0,17520708 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03580319 0,17483509 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03580319 0,17446468 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03580319 0,17409583 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03580319 0,17372854 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03580319 0,17336279 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03580319 0,17299859 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03580319 0,17263591 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03580319 0,17227474 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03580319 0,17191509 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03580319 0,17155693 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03580319 0,17120026 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03580319 0,17084508 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03580319 0,17049136 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03580319 0,1701391 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03580319 0,1697883 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03580319 0,16943894 ! neural tube patterning GO:0021532 6 5 0,000 0,03580319 0,16909102 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03580319 0,16874452 ! histone demethylation GO:0016577 9 5 0,000 0,03580319 0,16839944 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03580319 0,16805577 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03580319 0,1677135 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03580319 0,16737262 ! enteric nervous system development GO:0048484 8 5 0,000 0,03580319 0,16703312 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03580319 0,16669499 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03580319 0,16635824 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03580319 0,16602284 ! transcription termination GO:0006353 8 5 0,000 0,03580319 0,16568879 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03580319 0,16535608 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03580319 0,1650247 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03580319 0,16469465 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03580319 0,16436592 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03580319 0,1640385 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03580319 0,16371238 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03580319 0,16338755 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03580319 0,16306401 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03580319 0,16274175 ! apical protein localization GO:0045176 6 5 0,000 0,03580319 0,16242076 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03580319 0,16210104 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03580319 0,16178257 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03580319 0,16146535 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03580319 0,16114937 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03580319 0,16083462 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03580319 0,1605211 ! glial cell migration GO:0008347 10 5 0,000 0,03580319 0,16020881 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03580319 0,15989772 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03580319 0,15958784 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03580319 0,15927916 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03580319 0,15897167 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03580319 0,15866537 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03580319 0,15836024 ! neural plate development GO:0001840 6 5 0,000 0,03580319 0,15805629 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03580319 0,1577535 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03580319 0,15745187 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03580319 0,15715139 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03580319 0,15685205 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03580319 0,15655385 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03580319 0,15625679 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03580319 0,15596085 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03580319 0,15566602 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03580319 0,15537231 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03580319 0,15507971 ! spindle assembly GO:0051225 5 5 0,000 0,03580319 0,15478821 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03580319 0,1544978 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03580319 0,15420848 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03580319 0,15392024 ! organ regeneration GO:0031100 7 5 0,000 0,03580319 0,15363307 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03580319 0,15334698 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03580319 0,15306195 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03580319 0,15277797 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03580319 0,15249505 GO:0055081|anion homeostasis, ! protein localization in organelle GO:0033365 161 100 2,000 0,03638237 0,15467551 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,0373182 0,15836137 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,0373182 0,15806973 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,0373182 0,15777916 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 1,000 0,0373182 0,15748966 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,0373182 0,15720122 ! positive regulation of binding GO:0051099 59 43 1,000 0,03895626 0,16380147 ! activation of caspase activity GO:0006919 65 43 1,000 0,03895626 0,16350256 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,03895626 0,16320474 ! methylation GO:0032259 64 43 1,000 0,03895626 0,16290801 ! glycolysis GO:0006096 53 44 1,000 0,0406213 0,16956261 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,0406213 0,16925543 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,0406213 0,16894936 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,04231285 0,17566708 ! tRNA transcription GO:0009304 11 6 0,000 0,04280971 0,1774096 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04280971 0,17709052 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04280971 0,17677258 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04280971 0,17645579 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04280971 0,17614012 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04280971 0,17582559 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04280971 0,17551217 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04280971 0,17519987 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04280971 0,17488868 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04280971 0,1745786 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04280971 0,17426961 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04280971 0,17396171 ! prostate gland development GO:0030850 9 6 0,000 0,04280971 0,1736549 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04280971 0,17334917 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04280971 0,17304451 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04280971 0,17274093 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04280971 0,1724384 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04280971 0,17213694 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04280971 0,17183652 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04280971 0,17153716 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04280971 0,17123883 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04280971 0,17094154 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,04280971 0,17064528 ! neuron adhesion GO:0007158 9 6 0,000 0,04280971 0,17035005 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,04280971 0,17005584 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04280971 0,16976264 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04280971 0,16947045 ! signal peptide processing GO:0006465 8 6 0,000 0,04280971 0,16917926 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04280971 0,16888907 ! mRNA stabilization GO:0048255 15 6 0,000 0,04280971 0,16859988 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04280971 0,16831167 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04280971 0,16802445 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04280971 0,16773821 ! opsonization GO:0008228 8 6 0,000 0,04280971 0,16745294 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04280971 0,16716864 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04280971 0,1668853 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04280971 0,16660293 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04280971 0,1663215 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04280971 0,16604103 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04280971 0,1657615 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04280971 0,16548291 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04280971 0,16520525 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04280971 0,16492852 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04280971 0,16465272 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04280971 0,16437784 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04280971 0,16410388 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04280971 0,16383083 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04280971 0,16355869 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04280971 0,16328744 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04280971 0,1630171 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04280971 0,16274765 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04280971 0,16247909 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04280971 0,16221141 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04280971 0,16194462 ! thymic T cell selection GO:0045061 12 6 0,000 0,04280971 0,1616787 ! protein lipoylation GO:0009249 10 6 0,000 0,04280971 0,16141365 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04280971 0,16114947 ! pigment granule organization GO:0048753 11 6 0,000 0,04280971 0,16088616 ! drug transport GO:0015893 6 6 0,000 0,04280971 0,1606237 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04280971 0,1603621 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04280971 0,16010135 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04280971 0,15984144 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04280971 0,15958238 ! histidine metabolic process GO:0006547 6 6 0,000 0,04280971 0,15932416 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04280971 0,15906677 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04280971 0,15881021 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04280971 0,15855447 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04280971 0,15829956 ! adenohypophysis development GO:0021984 10 6 0,000 0,04280971 0,15804547 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04280971 0,15779219 ! microtubule nucleation GO:0007020 10 6 0,000 0,04280971 0,15753973 ! ER overload response GO:0006983 7 6 0,000 0,04280971 0,15728807 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04280971 0,15703721 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04280971 0,15678715 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04280971 0,15653788 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04280971 0,15628941 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04280971 0,15604173 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04280971 0,15579482 ! response to dietary excess GO:0002021 7 6 0,000 0,04280971 0,1555487 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04280971 0,15530336 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04280971 0,15505879 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04280971 0,15481498 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04280971 0,15457194 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04280971 0,15432967 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04280971 0,15408815 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04280971 0,15384739 ! organic alcohol transport GO:0015850 9 6 0,000 0,04280971 0,15360738 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04280971 0,15336811 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04280971 0,15312959 ! male sex determination GO:0030238 9 6 0,000 0,04280971 0,15289181 ! carnitine transport GO:0015879 8 6 0,000 0,04280971 0,15265477 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04280971 0,15241847 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04280971 0,15218289 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04280971 0,15194804 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04280971 0,15171391 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04280971 0,15148051 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04280971 0,15124782 ! parturition GO:0007567 12 6 0,000 0,04280971 0,15101584 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04280971 0,15078458 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04280971 0,15055402 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04280971 0,15032417 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04280971 0,15009501 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,04280971 0,14986656 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04280971 0,1496388 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04280971 0,14941173 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04280971 0,14918535 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04280971 0,14895965 ! macrophage differentiation GO:0030225 10 6 0,000 0,04280971 0,14873464 ! astrocyte development GO:0014002 14 6 0,000 0,04280971 0,1485103 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04280971 0,14828664 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04280971 0,14806365 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04280971 0,14784133 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04280971 0,14761968 ! eating behavior GO:0042755 6 6 0,000 0,04280971 0,1473987 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04280971 0,14717837 ! response to copper ion GO:0046688 9 6 0,000 0,04280971 0,1469587 ! DNA topological change GO:0006265 8 6 0,000 0,04280971 0,14673969 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04280971 0,14652132 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04280971 0,14630361 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04280971 0,14608654 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04280971 0,14587012 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04280971 0,14565433 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04280971 0,14543919 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04280971 0,14522467 ! gas homeostasis GO:0033483 11 6 0,000 0,04280971 0,14501079 ! hair follicle maturation GO:0048820 7 6 0,000 0,04280971 0,14479754 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04280971 0,14458492 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04280971 0,14437292 ! Schwann cell development GO:0014044 14 6 0,000 0,04280971 0,14416154 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04280971 0,14395077 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04280971 0,14374063 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04280971 0,14353109 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04280971 0,14332217 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04280971 0,14311385 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04280971 0,14290614 ! histone ubiquitination GO:0016574 7 6 0,000 0,04280971 0,14269903 ! regulation of meiosis GO:0040020 10 6 0,000 0,04280971 0,14249252 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04280971 0,1422866 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04280971 0,14208128 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04280971 0,14187655 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04280971 0,14167242 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04280971 0,14146886 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04280971 0,14126589 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04280971 0,14106351 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04280971 0,1408617 ! receptor internalization GO:0031623 9 6 0,000 0,04280971 0,14066047 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04280971 0,14045981 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04280971 0,14025973 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04280971 0,14006021 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04280971 0,13986126 ! protein deubiquitination GO:0016579 8 6 0,000 0,04280971 0,13966288 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04280971 0,13946505 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,04280971 0,13926779 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04280971 0,13907109 ! axonal fasciculation GO:0007413 9 6 0,000 0,04280971 0,13887493 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04280971 0,13867934 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04280971 0,13848429 ! midbrain development GO:0030901 6 6 0,000 0,04280971 0,13828979 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04280971 0,13809583 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04280971 0,13790242 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04280971 0,13770955 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04280971 0,13751722 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04280971 0,13732542 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04280971 0,13713416 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04280971 0,13694343 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04280971 0,13675323 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04280971 0,13656356 ! adult feeding behavior GO:0008343 6 6 0,000 0,04280971 0,13637442 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04280971 0,13618579 ! blastocyst growth GO:0001832 15 6 0,000 0,04280971 0,13599769 ! pigment granule transport GO:0051904 12 6 0,000 0,04280971 0,13581011 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04280971 0,13562304 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04280971 0,13543649 ! catecholamine transport GO:0051937 7 6 0,000 0,04280971 0,13525045 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04280971 0,13506492 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04280971 0,1348799 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04280971 0,13469539 ! protein prenylation GO:0018342 10 6 0,000 0,04280971 0,13451138 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04280971 0,13432787 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04280971 0,13414486 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04280971 0,13396235 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04280971 0,13378034 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04280971 0,13359882 ! regulation of ossification GO:0030278 71 46 1,000 0,04403045 0,13722226 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,04403045 0,13703657 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,04577362 0,14226936 ! endocrine system development GO:0035270 83 47 1,000 0,04577362 0,14207736 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,04577362 0,14188589 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,04577362 0,14169492 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,04577362 0,14150447 ! regulation of protein polymerization GO:0032271 71 47 1,000 0,04577362 0,14131453 ! chloride transport GO:0006821 67 48 1,000 0,04754192 0,14657697 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,04754192 0,14638075 GO:0010952|positive regulation of peptidase activity, ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,04754192 0,14618505 ! regulation of DNA replication GO:0006275 75 48 1,000 0,04754192 0,14598988 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,04754192 0,14579522 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,04754192 0,14560109 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,04754192 0,14540747 ! RNA elongation GO:0006354 62 49 1,000 0,0493349 0,15069092 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,0493349 0,15049106 ! germ cell development GO:0007281 68 49 1,000 0,0493349 0,15029173 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04976571 0,15140363 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04976571 0,15120362 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04976571 0,15100415 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04976571 0,1508052 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04976571 0,15060677 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04976571 0,15040886 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04976571 0,15021147 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04976571 0,1500146 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04976571 0,14981825 ! reproductive behavior GO:0019098 12 7 0,000 0,04976571 0,14962241 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04976571 0,14942708 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,04976571 0,14923226 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04976571 0,14903795 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,04976571 0,14884414 ! oligopeptide transport GO:0006857 11 7 0,000 0,04976571 0,14865084 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04976571 0,14845803 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04976571 0,14826573 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04976571 0,14807392 ! RNA methylation GO:0001510 11 7 0,000 0,04976571 0,14788261 ! pericardium development GO:0060039 8 7 0,000 0,04976571 0,1476918 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04976571 0,14750147 ! fibril organization GO:0043206 13 7 0,000 0,04976571 0,14731164 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04976571 0,14712229 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04976571 0,14693343 ! lipoprotein transport GO:0042953 9 7 0,000 0,04976571 0,14674506 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04976571 0,14655716 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04976571 0,14636975 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04976571 0,14618281 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04976571 0,14599636 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04976571 0,14581037 ! chemosensory behavior GO:0007635 9 7 0,000 0,04976571 0,14562486 ! microtubule bundle formation GO:0001578 8 7 0,000 0,04976571 0,14543983 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,04976571 0,14525526 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04976571 0,14507116 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04976571 0,14488752 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04976571 0,14470435 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04976571 0,14452165 ! reflex GO:0060004 12 7 0,000 0,04976571 0,1443394 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04976571 0,14415761 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04976571 0,14397628 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04976571 0,14379541 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04976571 0,14361499 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04976571 0,14343502 ! spinal cord patterning GO:0021511 7 7 0,000 0,04976571 0,1432555 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04976571 0,14307643 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04976571 0,14289781 ! adrenal gland development GO:0030325 17 7 0,000 0,04976571 0,14271963 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04976571 0,1425419 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04976571 0,14236461 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04976571 0,14218776 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04976571 0,14201134 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04976571 0,14183537 ! endosome organization GO:0007032 10 7 0,000 0,04976571 0,14165983 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04976571 0,14148473 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04976571 0,14131005 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04976571 0,14113581 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,04976571 0,140962 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04976571 0,14078861 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04976571 0,14061566 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04976571 0,14044312 ! galactose metabolic process GO:0006012 10 7 0,000 0,04976571 0,14027101 ! vesicle fusion GO:0006906 15 7 0,000 0,04976571 0,14009932 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04976571 0,13992805 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04976571 0,1397572 ! organ growth GO:0035265 11 7 0,000 0,04976571 0,13958676 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04976571 0,13941674 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04976571 0,13924713 ! retinol metabolic process GO:0042572 9 7 0,000 0,04976571 0,13907794 ! behavioral fear response GO:0001662 13 7 0,000 0,04976571 0,13890915 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04976571 0,13874078 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04976571 0,13857281 ! rRNA modification GO:0000154 12 7 0,000 0,04976571 0,13840525 ! protein heterooligomerization GO:0051291 10 7 0,000 0,04976571 0,1382381 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04976571 0,13807134 ! response to UV-B GO:0010224 11 7 0,000 0,04976571 0,13790499 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,04976571 0,13773904 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04976571 0,13757349 ! intermediate filament organization GO:0045109 11 7 0,000 0,04976571 0,13740834 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04976571 0,13724358 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04976571 0,13707921 ! fibrinolysis GO:0042730 9 7 0,000 0,04976571 0,13691524 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,04976571 0,13675166 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04976571 0,13658848 ! B cell lineage commitment GO:0002326 17 7 0,000 0,04976571 0,13642568 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04976571 0,13626327 ! response to tropane GO:0014073 13 7 0,000 0,04976571 0,13610124 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04976571 0,1359396 ! melanosome localization GO:0032400 10 7 0,000 0,04976571 0,13577834 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04976571 0,13561747 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04976571 0,13545697 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04976571 0,13529686 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04976571 0,13513712 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04976571 0,13497776 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04976571 0,13481878 ! mast cell activation GO:0045576 9 7 0,000 0,04976571 0,13466017 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04976571 0,13450193 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04976571 0,13434406 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04976571 0,13418657 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04976571 0,13402944 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04976571 0,13387268 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04976571 0,13371629 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04976571 0,13356026 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04976571 0,1334046 ! T cell lineage commitment GO:0002360 12 7 0,000 0,04976571 0,13324929 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04976571 0,13309435 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04976571 0,13293977 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04976571 0,13278555 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04976571 0,13263168 ! response to tumor cell GO:0002347 12 7 0,000 0,04976571 0,13247818 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04976571 0,13232502 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04976571 0,13217222 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04976571 0,13201977 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,04976571 0,13186768 ! diuresis GO:0030146 12 7 0,000 0,04976571 0,13171593 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04976571 0,13156453 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04976571 0,13141348 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04976571 0,13126278 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04976571 0,13111242 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04976571 0,13096241 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04976571 0,13081274 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04976571 0,13066341 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04976571 0,13051442 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04976571 0,13036577 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,04976571 0,13021746 ! lymph node development GO:0048535 9 7 0,000 0,04976571 0,13006948 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04976571 0,12992184 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04976571 0,12977454 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04976571 0,12962757 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04976571 0,12948093 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04976571 0,12933463 ! ATP catabolic process GO:0006200 10 7 0,000 0,04976571 0,12918865 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04976571 0,129043 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04976571 0,12889768 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04976571 0,12875269 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04976571 0,12860803 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04976571 0,12846369 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04976571 0,12831967 ! muscle adaptation GO:0043500 12 7 0,000 0,04976571 0,12817597 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04976571 0,1280326 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04976571 0,12788955 ! retina homeostasis GO:0001895 9 7 0,000 0,04976571 0,12774681 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04976571 0,1276044 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04976571 0,1274623 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04976571 0,12732052 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04976571 0,12717905 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04976571 0,12703789 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04976571 0,12689705 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04976571 0,12675653 ! regulation of actin filament length GO:0030832 72 50 1,000 0,0511521 0,13014362 ! ear development GO:0043583 72 50 1,000 0,0511521 0,12999981 ! lipid modification GO:0030258 73 50 1,000 0,0511521 0,12985632 ! positive regulation of growth GO:0045927 67 50 1,000 0,0511521 0,12971315 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,0511521 0,1295703 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,05299309 0,13408594 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of cell migration GO:0030335 92 51 1,000 0,05299309 0,13393859 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,05299309 0,13379157 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,05299309 0,13364486 ! regulation of cellular component size GO:0032535 74 52 1,000 0,05485744 0,13819509 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,05485744 0,13804389 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,05485744 0,13789302 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05667157 0,1422976 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05667157 0,14214242 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05667157 0,14198758 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,05667157 0,14183308 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05667157 0,14167891 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05667157 0,14152508 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05667157 0,14137159 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05667157 0,14121842 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05667157 0,14106559 ! phosphate transport GO:0006817 10 8 0,000 0,05667157 0,14091308 ! N-glycan processing GO:0006491 12 8 0,000 0,05667157 0,14076091 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05667157 0,14060906 ! UTP metabolic process GO:0046051 8 8 0,000 0,05667157 0,14045754 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05667157 0,14030635 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05667157 0,14015549 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,05667157 0,14000494 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05667157 0,13985472 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,05667157 0,13970482 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05667157 0,13955525 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05667157 0,13940599 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05667157 0,13925705 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05667157 0,13910843 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05667157 0,13896013 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05667157 0,13881214 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05667157 0,13866447 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05667157 0,13851711 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05667157 0,13837007 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05667157 0,13822333 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05667157 0,13807691 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05667157 0,1379308 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05667157 0,13778499 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05667157 0,13763949 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05667157 0,13749431 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05667157 0,13734942 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05667157 0,13720484 ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05667157 0,13706057 ! melanin metabolic process GO:0006582 12 8 0,000 0,05667157 0,1369166 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05667157 0,13677293 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05667157 0,13662956 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,05667157 0,13648649 ! macrophage activation GO:0042116 12 8 0,000 0,05667157 0,13634373 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05667157 0,13620126 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,05667157 0,13605908 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05667157 0,13591721 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05667157 0,13577563 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05667157 0,13563434 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05667157 0,13549335 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05667157 0,13535265 ! ruffle organization GO:0031529 11 8 0,000 0,05667157 0,13521224 ! osteoblast development GO:0002076 13 8 0,000 0,05667157 0,13507213 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05667157 0,1349323 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05667157 0,13479276 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05667157 0,13465351 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05667157 0,13451455 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05667157 0,13437588 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05667157 0,13423749 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05667157 0,13409938 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05667157 0,13396156 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,05667157 0,13382403 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,05667157 0,13368677 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05667157 0,1335498 ! segment specification GO:0007379 10 8 0,000 0,05667157 0,1334131 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05667157 0,13327669 ! cellular extravasation GO:0045123 11 8 0,000 0,05667157 0,13314055 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05667157 0,1330047 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05667157 0,13286911 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05667157 0,13273381 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,05667157 0,13259878 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05667157 0,13246403 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05667157 0,13232954 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05667157 0,13219534 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05667157 0,1320614 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,05667157 0,13192773 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05667157 0,13179434 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05667157 0,13166121 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05667157 0,13152836 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05667157 0,13139577 ! icosanoid secretion GO:0032309 12 8 0,000 0,05667157 0,13126345 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05667157 0,13113139 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05667157 0,1309996 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05667157 0,13086807 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05667157 0,13073681 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05667157 0,13060581 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05667157 0,13047508 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05667157 0,1303446 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05667157 0,13021439 ! sterol catabolic process GO:0016127 9 8 0,000 0,05667157 0,13008443 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05667157 0,12995474 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05667157 0,1298253 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05667157 0,12969612 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05667157 0,1295672 ! prophase GO:0051324 11 8 0,000 0,05667157 0,12943853 ! S phase GO:0051320 8 8 0,000 0,05667157 0,12931012 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05667157 0,12918196 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05667157 0,12905406 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05667157 0,12892641 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05667157 0,12879901 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05667157 0,12867187 ! hormone catabolic process GO:0042447 13 8 0,000 0,05667157 0,12854497 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05667157 0,12841833 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05667157 0,12829193 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05667157 0,12816578 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05667157 0,12803988 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05667157 0,12791423 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05667157 0,12778883 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05667157 0,12766366 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05667157 0,12753875 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05667157 0,12741408 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05667157 0,12728965 ! regulation of embryonic development GO:0045995 16 8 0,000 0,05667157 0,12716547 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05667157 0,12704152 GO:0000076|DNA replication checkpoint, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,05667157 0,12691782 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,05674471 0,12695801 ! cell projection assembly GO:0030031 76 53 1,000 0,05674471 0,12683463 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,05674471 0,12671149 ! regulation of protein complex assembly GO:0043254 81 54 1,000 0,05865448 0,13084899 ! glucose catabolic process GO:0006007 66 54 1,000 0,05865448 0,1307222 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,05865448 0,13059565 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,05865448 0,13046935 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,05865448 0,13034329 ! cellular amino acid catabolic process GO:0009063 74 54 1,000 0,05865448 0,13021748 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,05865448 0,13009191 ! positive regulation of cell motion GO:0051272 99 56 1,000 0,06253984 0,13857575 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06352762 0,140629 ! regulation of developmental growth GO:0048638 13 9 0,000 0,06352762 0,14049378 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,06352762 0,14035882 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06352762 0,14022412 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06352762 0,14008967 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06352762 0,13995549 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06352762 0,13982156 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06352762 0,13968789 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06352762 0,13955447 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06352762 0,13942131 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06352762 0,1392884 ! GTP metabolic process GO:0046039 9 9 0,000 0,06352762 0,13915574 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06352762 0,13902334 ! social behavior GO:0035176 14 9 0,000 0,06352762 0,13889119 ! artery development GO:0060840 19 9 0,000 0,06352762 0,13875929 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06352762 0,13862764 ! regulation of glycolysis GO:0006110 15 9 0,000 0,06352762 0,13849624 ! response to pain GO:0048265 16 9 0,000 0,06352762 0,13836508 ! protein complex disassembly GO:0043241 17 9 0,000 0,06352762 0,13823418 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06352762 0,13810352 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06352762 0,13797312 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06352762 0,13784295 ! lung alveolus development GO:0048286 17 9 0,000 0,06352762 0,13771303 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06352762 0,13758336 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06352762 0,13745393 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06352762 0,13732475 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06352762 0,1371958 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06352762 0,1370671 ! protein targeting to ER GO:0045047 19 9 0,000 0,06352762 0,13693864 ! T cell selection GO:0045058 18 9 0,000 0,06352762 0,13681042 ! endoderm development GO:0007492 12 9 0,000 0,06352762 0,13668244 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06352762 0,1365547 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06352762 0,1364272 ! arginine catabolic process GO:0006527 10 9 0,000 0,06352762 0,13629993 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06352762 0,13617291 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06352762 0,13604612 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06352762 0,13591956 ! V(D)J recombination GO:0033151 12 9 0,000 0,06352762 0,13579324 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06352762 0,13566716 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06352762 0,13554131 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06352762 0,13541569 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06352762 0,1352903 ! mannose metabolic process GO:0006013 9 9 0,000 0,06352762 0,13516515 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06352762 0,13504023 ! epithelial cell development GO:0002064 10 9 0,000 0,06352762 0,13491554 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06352762 0,13479108 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06352762 0,13466685 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06352762 0,13454284 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06352762 0,13441907 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06352762 0,13429552 ! motor axon guidance GO:0008045 14 9 0,000 0,06352762 0,1341722 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06352762 0,13404911 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06352762 0,13392624 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06352762 0,1338036 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,06352762 0,13368118 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06352762 0,13355898 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06352762 0,13343701 ! DNA ligation GO:0006266 14 9 0,000 0,06352762 0,13331526 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06352762 0,13319374 ! response to amine stimulus GO:0014075 13 9 0,000 0,06352762 0,13307243 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06352762 0,13295135 ! erythrocyte development GO:0048821 11 9 0,000 0,06352762 0,13283048 ! renal water homeostasis GO:0003091 14 9 0,000 0,06352762 0,13270984 ! postreplication repair GO:0006301 11 9 0,000 0,06352762 0,13258941 ! mRNA cleavage GO:0006379 13 9 0,000 0,06352762 0,1324692 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06352762 0,13234921 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06352762 0,13222944 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06352762 0,13210988 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06352762 0,13199054 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06352762 0,13187142 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06352762 0,13175251 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06352762 0,13163381 ! acid secretion GO:0046717 14 9 0,000 0,06352762 0,13151533 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06352762 0,13139706 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06352762 0,131279 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06352762 0,13116116 ! purine base metabolic process GO:0006144 18 9 0,000 0,06352762 0,13104352 ! thymus development GO:0048538 15 9 0,000 0,06352762 0,1309261 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06352762 0,13080889 ! spleen development GO:0048536 15 9 0,000 0,06352762 0,13069189 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06352762 0,13057509 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06352762 0,13045851 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06352762 0,13034213 ! detection of calcium ion GO:0005513 13 9 0,000 0,06352762 0,13022596 ! blastocyst formation GO:0001825 12 9 0,000 0,06352762 0,13011 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06352762 0,12999424 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06352762 0,12987869 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06352762 0,12976335 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06352762 0,12964821 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06352762 0,12953327 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06352762 0,12941854 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06352762 0,12930401 ! prepulse inhibition GO:0060134 14 9 0,000 0,06352762 0,12918968 ! embryonic placenta development GO:0001892 12 9 0,000 0,06352762 0,12907556 ! insulin secretion GO:0030073 17 9 0,000 0,06352762 0,12896163 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06352762 0,12884791 ! response to nicotine GO:0035094 16 9 0,000 0,06352762 0,12873439 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06352762 0,12862106 ! nucleus localization GO:0051647 15 9 0,000 0,06352762 0,12850794 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06352762 0,12839502 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,0665102 0,13430505 ! activation of MAPK activity GO:0000187 84 59 1,000 0,06852624 0,1382547 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07033424 0,14177804 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07033424 0,14165389 ! neuron fate specification GO:0048665 11 10 0,000 0,07033424 0,14152996 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07033424 0,14140625 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07033424 0,14128275 ! thyroid gland development GO:0030878 19 10 0,000 0,07033424 0,14115946 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07033424 0,14103639 ! synapsis GO:0007129 13 10 0,000 0,07033424 0,14091354 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07033424 0,1407909 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07033424 0,14066847 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07033424 0,14054626 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,07033424 0,14042426 ! sulfate transport GO:0008272 12 10 0,000 0,07033424 0,14030247 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07033424 0,14018089 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07033424 0,14005952 ! androgen metabolic process GO:0008209 13 10 0,000 0,07033424 0,13993836 ! phospholipid efflux GO:0033700 16 10 0,000 0,07033424 0,13981741 ! hippocampus development GO:0021766 19 10 0,000 0,07033424 0,13969667 ! blood vessel remodeling GO:0001974 21 10 0,000 0,07033424 0,13957614 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07033424 0,13945581 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07033424 0,1393357 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,07033424 0,13921579 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07033424 0,13909608 ! pathogenesis GO:0009405 13 10 0,000 0,07033424 0,13897658 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07033424 0,13885729 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,07033424 0,1387382 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07033424 0,13861932 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,07033424 0,13850064 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07033424 0,13838216 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07033424 0,13826388 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07033424 0,13814581 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07033424 0,13802794 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07033424 0,13791027 ! response to X-ray GO:0010165 16 10 0,000 0,07033424 0,1377928 ! B cell proliferation GO:0042100 14 10 0,000 0,07033424 0,13767553 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07033424 0,13755846 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07033424 0,13744158 ! forebrain cell migration GO:0021885 17 10 0,000 0,07033424 0,13732491 ! lipid digestion GO:0044241 15 10 0,000 0,07033424 0,13720843 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07033424 0,13709216 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07033424 0,13697607 ! UV protection GO:0009650 14 10 0,000 0,07033424 0,13686019 ! entry into host cell GO:0030260 20 10 0,000 0,07033424 0,1367445 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07033424 0,13662901 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07033424 0,13651371 ! negative regulation of ossification GO:0030279 19 10 0,000 0,07033424 0,1363986 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07033424 0,13628369 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,07033424 0,13616898 ! regulation of bone resorption GO:0045124 24 10 0,000 0,07033424 0,13605445 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,07033424 0,13594012 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07033424 0,13582598 ! regulation of organ growth GO:0046620 11 10 0,000 0,07033424 0,13571203 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07033424 0,13559828 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07033424 0,13548471 ! embryonic axis specification GO:0000578 12 10 0,000 0,07033424 0,13537133 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07033424 0,13525815 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07033424 0,13514515 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07033424 0,13503234 ! fucose catabolic process GO:0019317 16 10 0,000 0,07033424 0,13491972 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07033424 0,13480729 ! protein sumoylation GO:0016925 12 10 0,000 0,07033424 0,13469504 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07033424 0,13458298 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07033424 0,13447111 ! zymogen activation GO:0031638 14 10 0,000 0,07033424 0,13435942 ! salivary gland development GO:0007431 22 10 0,000 0,07033424 0,13424792 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07033424 0,1341366 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07033424 0,13402547 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07033424 0,13391452 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07033424 0,13380376 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,07033424 0,13369318 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07033424 0,13358278 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07033424 0,13347256 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07033424 0,13336253 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07033424 0,13325267 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,07033424 0,133143 GO:0043470|regulation of carbohydrate catabolic process, ! detection of bacterium GO:0016045 10 10 0,000 0,07033424 0,13303351 ! embryonic gut development GO:0048566 11 10 0,000 0,07033424 0,13292419 ! activation of innate immune response GO:0002218 10 10 0,000 0,07033424 0,13281506 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07033424 0,13270611 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07033424 0,13259733 ! developmental induction GO:0031128 13 10 0,000 0,07033424 0,13248873 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07033424 0,13238031 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07033424 0,13227207 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07033424 0,13216401 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,07056234 0,13248439 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,07056234 0,13237632 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,07261808 0,13612191 ! meiosis GO:0007126 96 61 1,000 0,07261808 0,13601107 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,07261808 0,1359004 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,07261808 0,13578991 ! amine catabolic process GO:0009310 90 62 1,000 0,07469309 0,13955655 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,07469309 0,13944328 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,07469309 0,13933018 ! meiotic cell cycle GO:0051321 97 62 1,000 0,07469309 0,13921728 ! organelle localization GO:0051640 96 62 1,000 0,07469309 0,13910455 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,07678699 0,14288841 ! regulation of lipase activity GO:0060191 109 63 1,000 0,07678699 0,1427729 ! rRNA transcription GO:0009303 17 11 0,000 0,07709177 0,1432238 ! respiratory burst GO:0045730 14 11 0,000 0,07709177 0,1431082 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07709177 0,14299279 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,07709177 0,14287757 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07709177 0,14276253 ! virus-host interaction GO:0019048 17 11 0,000 0,07709177 0,14264768 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,07709177 0,14253301 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,07709177 0,14241852 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07709177 0,14230422 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07709177 0,14219011 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,07709177 0,14207617 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,07709177 0,14196242 ! T cell proliferation GO:0042098 20 11 0,000 0,07709177 0,14184885 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,07709177 0,14173546 ! bone resorption GO:0045453 16 11 0,000 0,07709177 0,14162225 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07709177 0,14150923 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07709177 0,14139638 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,07709177 0,14128371 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,07709177 0,14117123 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07709177 0,14105892 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07709177 0,14094679 ! syncytium formation GO:0006949 15 11 0,000 0,07709177 0,14083484 ! plasma membrane organization GO:0007009 18 11 0,000 0,07709177 0,14072307 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,07709177 0,14061147 ! focal adhesion formation GO:0048041 24 11 0,000 0,07709177 0,14050005 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07709177 0,14038881 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07709177 0,14027774 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,07709177 0,14016685 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07709177 0,14005613 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07709177 0,13994559 ! adult heart development GO:0007512 11 11 0,000 0,07709177 0,13983522 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,07709177 0,13972503 ! temperature homeostasis GO:0001659 16 11 0,000 0,07709177 0,13961501 ! L-glutamate transport GO:0015813 16 11 0,000 0,07709177 0,13950516 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,07709177 0,13939549 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07709177 0,13928599 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07709177 0,13917666 ! stem cell development GO:0048864 29 11 0,000 0,07709177 0,1390675 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07709177 0,13895851 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07709177 0,1388497 ! vasoconstriction GO:0042310 15 11 0,000 0,07709177 0,13874105 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,07709177 0,13863257 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,07709177 0,13852427 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07709177 0,13841613 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07709177 0,13830816 ! ribosome assembly GO:0042255 13 11 0,000 0,07709177 0,13820036 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,07709177 0,13809273 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,07709177 0,13798526 ! chromatin silencing GO:0006342 19 11 0,000 0,07709177 0,13787796 ! nucleosome positioning GO:0016584 13 11 0,000 0,07709177 0,13777083 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07709177 0,13766387 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,07709177 0,13755707 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07709177 0,13745044 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07709177 0,13734397 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07709177 0,13723766 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07709177 0,13713153 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07709177 0,13702555 ! male genitalia development GO:0030539 13 11 0,000 0,07709177 0,13691974 ! cholesterol efflux GO:0033344 19 11 0,000 0,07709177 0,13681409 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,07709177 0,13670861 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07709177 0,13660328 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07709177 0,13649812 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,07709177 0,13639312 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,07709177 0,13628829 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07709177 0,13618361 ! defense response to fungus GO:0050832 12 11 0,000 0,07709177 0,1360791 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07709177 0,13597474 ! lysogeny GO:0030069 18 11 0,000 0,07709177 0,13587055 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,07709177 0,13576651 ! acrosome reaction GO:0007340 13 11 0,000 0,07709177 0,13566263 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07709177 0,13555892 ! negative regulation of cell size GO:0045792 108 64 1,000 0,07889939 0,13863147 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,07889939 0,13852564 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,07889939 0,13841998 ! hexose catabolic process GO:0019320 82 64 1,000 0,07889939 0,13831448 ! adaptive immune response GO:0002250 94 64 1,000 0,07889939 0,13820913 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of caspase activity GO:0043281 97 65 1,000 0,08102992 0,14183319 ! defense response to bacterium GO:0042742 73 65 1,000 0,08102992 0,14172533 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,08102992 0,14161764 ! activation of immune response GO:0002253 83 65 1,000 0,08102992 0,14151011 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,08317821 0,14515165 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,08317821 0,1450416 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,08317821 0,14493172 ! regulation of immune effector process GO:0002697 101 66 1,000 0,08317821 0,14482201 ! lactation GO:0007595 20 12 0,000 0,08380056 0,14579523 ! reproductive cellular process GO:0048610 14 12 0,000 0,08380056 0,14568503 ! tRNA modification GO:0006400 14 12 0,000 0,08380056 0,14557499 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08380056 0,14546512 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08380056 0,14535542 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,08380056 0,14524588 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08380056 0,14513651 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08380056 0,14502731 ! non-recombinational repair GO:0000726 19 12 0,000 0,08380056 0,14491826 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08380056 0,14480938 ! peroxisomal transport GO:0043574 21 12 0,000 0,08380056 0,14470067 ! cartilage condensation GO:0001502 18 12 0,000 0,08380056 0,14459211 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,08380056 0,14448372 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08380056 0,1443755 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08380056 0,14426743 ! heart looping GO:0001947 15 12 0,000 0,08380056 0,14415953 ! palate development GO:0060021 15 12 0,000 0,08380056 0,14405179 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08380056 0,1439442 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08380056 0,14383678 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,08380056 0,14372952 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08380056 0,14362242 ! arginine metabolic process GO:0006525 13 12 0,000 0,08380056 0,14351548 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08380056 0,1434087 ! methionine metabolic process GO:0006555 13 12 0,000 0,08380056 0,14330207 ! Golgi organization GO:0007030 18 12 0,000 0,08380056 0,14319561 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08380056 0,1430893 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08380056 0,14298315 ! monoamine transport GO:0015844 13 12 0,000 0,08380056 0,14287716 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08380056 0,14277133 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,08380056 0,14266565 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08380056 0,14256012 ! L-amino acid transport GO:0015807 20 12 0,000 0,08380056 0,14245476 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08380056 0,14234955 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08380056 0,14224449 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08380056 0,14213959 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08380056 0,14203485 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08380056 0,14193026 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08380056 0,14182582 ! cerebellum development GO:0021549 13 12 0,000 0,08380056 0,14172154 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08380056 0,14161741 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08380056 0,14151343 ! histone acetylation GO:0016573 23 12 0,000 0,08380056 0,1414096 ! histone methylation GO:0016571 15 12 0,000 0,08380056 0,14130593 ! autonomic nervous system development GO:0048483 23 12 0,000 0,08380056 0,14120241 ! gland morphogenesis GO:0022612 23 12 0,000 0,08380056 0,14109904 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08380056 0,14099582 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,08380056 0,14089276 ! response to gamma radiation GO:0010332 20 12 0,000 0,08380056 0,14078984 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08380056 0,14068707 ! intestinal absorption GO:0050892 19 12 0,000 0,08380056 0,14058446 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08380056 0,14048199 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08380056 0,14037967 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08380056 0,1402775 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08380056 0,14017548 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,08380056 0,14007361 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08380056 0,13997189 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08380056 0,13987031 ! microspike assembly GO:0030035 23 12 0,000 0,08380056 0,13976888 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08380056 0,1396676 ! response to cold GO:0009409 14 12 0,000 0,08380056 0,13956647 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,08534389 0,14203397 ! learning or memory GO:0007611 123 68 1,000 0,08752661 0,14556124 ! inorganic anion transport GO:0015698 93 68 1,000 0,08752661 0,14545607 ! response to drug GO:0042493 108 69 1,000 0,089726 0,14900347 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,09046097 0,1501156 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09046097 0,15000737 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09046097 0,1498993 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,09046097 0,14979138 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09046097 0,14968362 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09046097 0,14957601 ! lipid localization GO:0010876 24 13 0,000 0,09046097 0,14946855 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09046097 0,14936125 ! organelle fusion GO:0048284 28 13 0,000 0,09046097 0,14925411 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09046097 0,14914712 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,09046097 0,14904028 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,09046097 0,14893359 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09046097 0,14882706 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09046097 0,14872068 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,09046097 0,14861445 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09046097 0,14850837 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09046097 0,14840244 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,09046097 0,14829667 ! NAD metabolic process GO:0019674 21 13 0,000 0,09046097 0,14819105 ! exocrine system development GO:0035272 27 13 0,000 0,09046097 0,14808557 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,09046097 0,14798025 ! bone mineralization GO:0030282 15 13 0,000 0,09046097 0,14787507 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09046097 0,14777005 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09046097 0,14766517 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09046097 0,14756045 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09046097 0,14745587 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,09046097 0,14735144 ! genitalia development GO:0048806 15 13 0,000 0,09046097 0,14724715 ! regulation of cellular pH GO:0030641 20 13 0,000 0,09046097 0,14714302 ! cellular pigmentation GO:0033059 24 13 0,000 0,09046097 0,14703903 ! tissue regeneration GO:0042246 21 13 0,000 0,09046097 0,14693519 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09046097 0,14683149 ! cofactor transport GO:0051181 19 13 0,000 0,09046097 0,14672795 ! NADP metabolic process GO:0006739 18 13 0,000 0,09046097 0,14662454 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09046097 0,14652129 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09046097 0,14641818 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09046097 0,14631521 ! gas transport GO:0015669 18 13 0,000 0,09046097 0,14621239 ! regulation of RNA stability GO:0043487 28 13 0,000 0,09046097 0,14610971 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09046097 0,14600718 ! regulation of axon extension GO:0030516 23 13 0,000 0,09046097 0,14590479 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09046097 0,14580254 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09046097 0,14570044 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09046097 0,14559848 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09046097 0,14549666 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09046097 0,14539499 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,09194172 0,14767175 ! humoral immune response GO:0006959 86 70 1,000 0,09194172 0,1475687 ! regulation of catabolic process GO:0009894 106 70 1,000 0,09194172 0,14746579 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,09417341 0,15093996 ! monosaccharide catabolic process GO:0046365 91 71 1,000 0,09417341 0,15083485 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,09642073 0,15432685 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,09707334 0,15526333 ! superoxide anion generation GO:0042554 18 14 0,000 0,09707334 0,15515544 ! regulation of S phase GO:0033261 18 14 0,000 0,09707334 0,15504769 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09707334 0,15494009 ! myotube differentiation GO:0014902 21 14 0,000 0,09707334 0,15483264 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,09707334 0,15472535 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09707334 0,1546182 ! inositol metabolic process GO:0006020 20 14 0,000 0,09707334 0,15451119 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09707334 0,15440434 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09707334 0,15429763 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,09707334 0,15419107 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09707334 0,15408466 ! response to cAMP GO:0051591 19 14 0,000 0,09707334 0,1539784 ! limbic system development GO:0021761 25 14 0,000 0,09707334 0,15387228 ! startle response GO:0001964 21 14 0,000 0,09707334 0,1537663 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,09707334 0,15366048 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09707334 0,1535548 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,09707334 0,15344926 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09707334 0,15334387 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,09707334 0,15323862 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,09707334 0,15313352 ! glycine metabolic process GO:0006544 22 14 0,000 0,09707334 0,15302856 ! pituitary gland development GO:0021983 23 14 0,000 0,09707334 0,15292375 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,09707334 0,15281908 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,09707334 0,15271455 ! regulation of heart rate GO:0002027 23 14 0,000 0,09707334 0,15261017 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09707334 0,15250592 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09707334 0,15240183 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,09707334 0,15229787 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,09707334 0,15219405 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,09707334 0,15209038 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,09707334 0,15198684 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09707334 0,15188345 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09707334 0,1517802 ! axon cargo transport GO:0008088 27 14 0,000 0,09707334 0,15167709 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09707334 0,15157412 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09707334 0,15147128 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,09707334 0,15136859 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,09707334 0,15126604 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09707334 0,15116362 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09707334 0,15106135 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09707334 0,15095921 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09707334 0,15085721 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09707334 0,15075535 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09707334 0,15065363 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09707334 0,15055204 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,09707334 0,15045059 ! muscle maintenance GO:0046716 19 14 0,000 0,09707334 0,15034928 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09707334 0,1502481 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09707334 0,15014706 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,09707334 0,15004615 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,09707334 0,14994538 ! cilium assembly GO:0042384 20 14 0,000 0,09707334 0,14984475 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09707334 0,14974425 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,09868334 0,15212579 ! blood coagulation GO:0007596 116 75 1,000 0,10325309 0,1590637 GO:0050817|coagulation, ! negative regulation of growth GO:0045926 123 75 1,000 0,10325309 0,15895724 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10363801 0,15944309 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10363801 0,15933651 ! metencephalon development GO:0022037 19 15 0,000 0,10363801 0,15923007 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10363801 0,15912378 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10363801 0,15901762 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,10363801 0,15891161 ! skin development GO:0043588 25 15 0,000 0,10363801 0,15880574 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10363801 0,15870001 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,10363801 0,15859442 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,10363801 0,15848898 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10363801 0,15838367 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10363801 0,1582785 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10363801 0,15817347 ! adult walking behavior GO:0007628 25 15 0,000 0,10363801 0,15806858 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10363801 0,15796383 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10363801 0,15785922 ! myoblast differentiation GO:0045445 27 15 0,000 0,10363801 0,15775474 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10363801 0,15765041 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10363801 0,15754621 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10363801 0,15744215 ! cerebral cortex development GO:0021987 29 15 0,000 0,10363801 0,15733823 ! vesicle coating GO:0006901 25 15 0,000 0,10363801 0,15723445 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,10363801 0,1571308 ! DNA integration GO:0015074 22 15 0,000 0,10363801 0,15702729 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,10363801 0,15692391 ! peptide secretion GO:0002790 27 15 0,000 0,10363801 0,15682067 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10363801 0,15671757 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10363801 0,1566146 ! neuron recognition GO:0008038 22 15 0,000 0,10363801 0,15651177 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10363801 0,15640907 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,10363801 0,1563065 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10363801 0,15620408 ! biomineral formation GO:0031214 18 15 0,000 0,10363801 0,15610178 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10363801 0,15599962 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10363801 0,15589759 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10363801 0,1557957 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10363801 0,15569394 ! organic cation transport GO:0015695 19 15 0,000 0,10363801 0,15559231 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10363801 0,15549081 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10363801 0,15538945 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,10363801 0,15528822 ! defense response to virus GO:0051607 27 15 0,000 0,10363801 0,15518712 ! peptide hormone processing GO:0016486 19 15 0,000 0,10363801 0,15508615 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,10363801 0,15498532 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,10788002 0,1612242 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,10788002 0,16111951 ! protein secretion GO:0009306 27 16 0,000 0,11015533 0,16441093 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,11015533 0,16430431 ! hormone secretion GO:0046879 25 16 0,000 0,11015533 0,16419783 ! bone remodeling GO:0046849 24 16 0,000 0,11015533 0,16409148 ! endothelial cell migration GO:0043542 22 16 0,000 0,11015533 0,16398527 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11015533 0,1638792 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,11015533 0,16377327 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11015533 0,16366747 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11015533 0,16356181 ! glial cell development GO:0021782 24 16 0,000 0,11015533 0,16345629 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11015533 0,1633509 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11015533 0,16324565 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11015533 0,16314053 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11015533 0,16303555 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11015533 0,16293071 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,11015533 0,16282599 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11015533 0,16272142 ! fructose metabolic process GO:0006000 20 16 0,000 0,11015533 0,16261698 ! regulation of protein binding GO:0043393 27 16 0,000 0,11015533 0,16251267 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11015533 0,16240849 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,11015533 0,16230445 ! protein export from nucleus GO:0006611 24 16 0,000 0,11015533 0,16220054 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11015533 0,16209677 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11015533 0,16199313 ! DNA replication initiation GO:0006270 25 16 0,000 0,11015533 0,16188962 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11015533 0,16178624 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11015533 0,16168299 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11015533 0,16157988 ! diencephalon development GO:0021536 25 16 0,000 0,11015533 0,16147689 ! neural crest cell migration GO:0001755 24 16 0,000 0,11015533 0,16137404 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,11015533 0,16127132 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11015533 0,16116873 GO:0006626|protein targeting to mitochondrion, ! steroid catabolic process GO:0006706 22 16 0,000 0,11015533 0,16106627 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11015533 0,16096394 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,11015533 0,16086174 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11015533 0,16075967 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11015533 0,16065773 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11015533 0,16055592 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11015533 0,16045424 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11015533 0,16035269 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11015533 0,16025126 ! negative regulation of translation GO:0017148 22 16 0,000 0,11015533 0,16014997 ! positive regulation of protein modification process GO:0031401 107 78 1,000 0,11021411 0,16013421 ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,11021411 0,16003312 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,11021411 0,15993215 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,11256154 0,16323552 ! T cell activation GO:0042110 134 79 1,000 0,11256154 0,16313267 ! regulation of lyase activity GO:0051339 133 79 1,000 0,11256154 0,16302994 ! ATP biosynthetic process GO:0006754 118 79 1,000 0,11256154 0,16292734 ! alcohol catabolic process GO:0046164 104 80 1,000 0,11492198 0,16623935 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,11662563 0,1685977 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,11662563 0,1684918 ! negative regulation of defense response GO:0031348 19 17 0,000 0,11662563 0,16838603 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,11662563 0,16828039 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,11662563 0,16817488 ! glycerol metabolic process GO:0006071 20 17 0,000 0,11662563 0,16806951 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,11662563 0,16796427 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,11662563 0,16785916 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,11662563 0,16775418 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,11662563 0,16764934 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,11662563 0,16754462 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,11662563 0,16744004 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,11662563 0,16733558 ! keratinization GO:0031424 17 17 0,000 0,11662563 0,16723126 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,11662563 0,16712707 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,11662563 0,167023 ! retinoid metabolic process GO:0001523 22 17 0,000 0,11662563 0,16691907 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,11662563 0,16681526 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,11662563 0,16671158 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,11662563 0,16660804 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,11662563 0,16650462 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,11662563 0,16640133 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,11662563 0,16629816 ! membrane budding GO:0006900 29 17 0,000 0,11662563 0,16619513 ! heme metabolic process GO:0042168 27 17 0,000 0,11662563 0,16609222 ! actin filament bundle formation GO:0051017 26 17 0,000 0,11662563 0,16598944 ! neuromuscular junction development GO:0007528 23 17 0,000 0,11662563 0,16588679 ! body fluid secretion GO:0007589 27 17 0,000 0,11662563 0,16578426 ! stem cell differentiation GO:0048863 36 17 0,000 0,11662563 0,16568187 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,11662563 0,16557959 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,11662563 0,16547745 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,11662563 0,16537543 ! sensory perception of pain GO:0019233 23 17 0,000 0,11662563 0,16527353 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,11662563 0,16517176 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,11662563 0,16507012 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,11662563 0,1649686 ! synaptogenesis GO:0007416 24 17 0,000 0,11662563 0,1648672 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,11662563 0,16476593 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,11662563 0,16466479 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,11662563 0,16456377 ! cell-cell junction organization GO:0045216 25 17 0,000 0,11662563 0,16446287 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,11662563 0,1643621 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,11662563 0,16426144 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,11662563 0,16416092 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,11662563 0,16406051 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,11729514 0,16490148 ! hemostasis GO:0007599 125 81 1,000 0,11729514 0,16480074 ! response to protein stimulus GO:0051789 111 81 1,000 0,11729514 0,16470013 ! ossification GO:0001503 134 82 1,000 0,11968069 0,16794728 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,12207835 0,17120745 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,12304925 0,17246391 ! positive regulation of translation GO:0045727 28 18 0,000 0,12304925 0,17235887 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,12304925 0,17225397 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,12304925 0,17214919 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12304925 0,17204454 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,12304925 0,17194002 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12304925 0,17183562 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12304925 0,17173135 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,12304925 0,17162721 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12304925 0,17152319 ! axis specification GO:0009798 26 18 0,000 0,12304925 0,1714193 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,12304925 0,17131554 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12304925 0,1712119 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12304925 0,17110838 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12304925 0,171005 ! response to retinoic acid GO:0032526 25 18 0,000 0,12304925 0,17090173 ! pigmentation during development GO:0048066 31 18 0,000 0,12304925 0,17079859 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12304925 0,17069558 ! fucose metabolic process GO:0006004 26 18 0,000 0,12304925 0,17059269 ! response to fungus GO:0009620 19 18 0,000 0,12304925 0,17048992 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12304925 0,17038728 ! heart process GO:0003015 27 18 0,000 0,12304925 0,17028476 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12304925 0,17018236 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,12304925 0,17008009 ! somitogenesis GO:0001756 24 18 0,000 0,12304925 0,16997794 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12304925 0,16987591 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12304925 0,16977401 ! vitamin transport GO:0051180 24 18 0,000 0,12304925 0,16967222 ! hormone transport GO:0009914 27 18 0,000 0,12304925 0,16957056 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,12304925 0,16946902 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12304925 0,16936761 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,12304925 0,16926631 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12304925 0,16916513 ! cell-cell recognition GO:0009988 20 18 0,000 0,12304925 0,16906408 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,12304925 0,16896315 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12304925 0,16886233 ! regulation of glucose import GO:0046324 21 18 0,000 0,12304925 0,16876164 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,12304925 0,16866107 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,12304925 0,16856061 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,12304925 0,16846028 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,12448782 0,17032836 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,12690879 0,17353759 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,12934098 0,17675833 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,12942652 0,17677019 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,12942652 0,17666528 ! positive regulation of ossification GO:0045778 30 19 0,000 0,12942652 0,1765605 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,12942652 0,17645584 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,12942652 0,17635131 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,12942652 0,17624689 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,12942652 0,17614261 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,12942652 0,17603844 GO:0010675|regulation of cellular carbohydrate metabolic process, ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,12942652 0,1759344 ! regeneration GO:0031099 32 19 0,000 0,12942652 0,17583048 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,12942652 0,17572668 ! sensory perception of taste GO:0050909 23 19 0,000 0,12942652 0,17562301 ! smooth muscle contraction GO:0006939 36 19 0,000 0,12942652 0,17551946 ! peroxisome organization GO:0007031 29 19 0,000 0,12942652 0,17541603 ! digestive system process GO:0022600 30 19 0,000 0,12942652 0,17531272 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,12942652 0,17520954 ! response to vitamin A GO:0033189 26 19 0,000 0,12942652 0,17510647 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,12942652 0,17500353 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,12942652 0,17490071 ! plasma membrane fusion GO:0045026 23 19 0,000 0,12942652 0,17479801 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,12942652 0,17469542 ! cytolysis GO:0019835 20 19 0,000 0,12942652 0,17459296 ! renal system process GO:0003014 35 19 0,000 0,12942652 0,17449062 ! vasodilation GO:0042311 33 19 0,000 0,12942652 0,1743884 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,12942652 0,1742863 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,12942652 0,17418432 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,12942652 0,17408246 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,12942652 0,17398071 ! sarcomere organization GO:0045214 23 19 0,000 0,12942652 0,17387909 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,12942652 0,17377758 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,12942652 0,1736762 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,12942652 0,17357493 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,12942652 0,17347378 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,12942652 0,17337274 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,12942652 0,17327183 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 1,000 0,13178411 0,17632545 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 1,000 0,13423788 0,17950414 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,13423788 0,17939984 GO:0016054|organic acid catabolic process, ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,13575779 0,18132573 ! iron ion transport GO:0006826 37 20 0,000 0,13575779 0,18122049 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,13575779 0,18111537 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,13575779 0,18101038 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,13575779 0,18090551 ! response to vitamin GO:0033273 29 20 0,000 0,13575779 0,18080076 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,13575779 0,18069613 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,13575779 0,18059162 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,13575779 0,18048723 ! spinal cord development GO:0021510 31 20 0,000 0,13575779 0,18038296 ! response to ethanol GO:0045471 37 20 0,000 0,13575779 0,18027881 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,13575779 0,18017479 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,13575779 0,18007088 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,13575779 0,17996709 ! chromosome condensation GO:0030261 31 20 0,000 0,13575779 0,17986343 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,13575779 0,17975988 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,13575779 0,17965645 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,13575779 0,17955314 ! pallium development GO:0021543 38 20 0,000 0,13575779 0,17944995 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,13575779 0,17934687 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,13575779 0,17924392 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,13575779 0,17914108 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,13575779 0,17903836 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,13575779 0,17893576 ! collagen catabolic process GO:0030574 25 20 0,000 0,13575779 0,17883328 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,13575779 0,17873091 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,13575779 0,17862866 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,13575779 0,17852653 ! alditol metabolic process GO:0019400 24 20 0,000 0,13575779 0,17842452 ! reproductive developmental process GO:0003006 127 89 1,000 0,13670202 0,1795629 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 1,000 0,13670202 0,17946041 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,13670202 0,17935804 ! response to virus GO:0009615 122 91 1,000 0,1416603 0,18575752 ! ATP metabolic process GO:0046034 137 91 1,000 0,1416603 0,18565167 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,14204336 0,18604769 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,14204336 0,1859418 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,14204336 0,18583603 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14204336 0,18573038 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14204336 0,18562485 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,14204336 0,18551944 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14204336 0,18541415 GO:0034105|positive regulation of tissue remodeling, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,14204336 0,18530898 ! protein amino acid acylation GO:0043543 37 21 0,000 0,14204336 0,18520393 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,14204336 0,185099 ! vesicle docking GO:0048278 27 21 0,000 0,14204336 0,18499419 ! phototransduction GO:0007602 25 21 0,000 0,14204336 0,18488949 ! dendrite development GO:0016358 35 21 0,000 0,14204336 0,18478492 ! visual behavior GO:0007632 39 21 0,000 0,14204336 0,18468046 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,14204336 0,18457612 ! ovarian follicle development GO:0001541 30 21 0,000 0,14204336 0,1844719 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14204336 0,1843678 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,14204336 0,18426381 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,14204336 0,18415994 ! cell aging GO:0007569 32 21 0,000 0,14204336 0,18405619 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,14204336 0,18395255 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,14204336 0,18384903 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,14204336 0,18374563 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,14204336 0,18364235 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,14204336 0,18353918 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,14204336 0,18343612 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14204336 0,18333318 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14204336 0,18323036 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,14204336 0,18312765 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14204336 0,18302506 ! fatty acid transport GO:0015908 30 21 0,000 0,14204336 0,18292258 ! immunoglobulin production GO:0002377 33 21 0,000 0,14204336 0,18282022 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,14204336 0,18271797 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,14204336 0,18261584 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,14204336 0,18251382 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,14204336 0,18241191 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,14204336 0,18231012 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,14204336 0,18220844 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,14204336 0,18210688 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14204336 0,18200542 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14204336 0,18190408 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,14204336 0,18180286 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,14204336 0,18170174 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,14204336 0,18160074 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14204336 0,18149985 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,1441539 0,18409437 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,1441539 0,18399221 ! cell fate commitment GO:0045165 141 92 1,000 0,1441539 0,18389016 ! sulfur metabolic process GO:0006790 118 92 1,000 0,1441539 0,18378823 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,14665677 0,18687567 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,14665677 0,18677219 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,14828358 0,18873948 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,14828358 0,18863509 ! viral genome replication GO:0019079 29 22 0,000 0,14828358 0,18853081 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,14828358 0,18842665 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,14828358 0,18832261 ! leukocyte adhesion GO:0007159 38 22 0,000 0,14828358 0,18821868 ! molting cycle process GO:0022404 40 22 0,000 0,14828358 0,18811486 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 0,000 0,14828358 0,18801116 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,14828358 0,18790757 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,14828358 0,1878041 ! vasculogenesis GO:0001570 33 22 0,000 0,14828358 0,18770074 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,14828358 0,18759749 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,14828358 0,18749436 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,14828358 0,18739134 ! lysosome organization GO:0007040 37 22 0,000 0,14828358 0,18728844 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,14828358 0,18718564 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,14828358 0,18708296 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,14828358 0,1869804 ! regulation of behavior GO:0050795 38 22 0,000 0,14828358 0,18687794 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,14828358 0,1867756 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,14828358 0,18667337 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,14828358 0,18657125 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,14828358 0,18646924 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,14828358 0,18636735 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,14828358 0,18626556 ! blastocyst development GO:0001824 37 22 0,000 0,14828358 0,18616389 ! neural tube closure GO:0001843 33 22 0,000 0,14828358 0,18606233 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,14828358 0,18596087 ! protein tetramerization GO:0051262 39 22 0,000 0,14828358 0,18585953 ! in utero embryonic development GO:0001701 147 96 1,000 0,15421848 0,19319308 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,15421848 0,19308791 ! neuron fate commitment GO:0048663 32 23 0,000 0,15447877 0,19330858 ! embryonic pattern specification GO:0009880 31 23 0,000 0,15447877 0,19320347 ! myelination GO:0042552 35 23 0,000 0,15447877 0,19309846 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,15447877 0,19299358 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,15447877 0,1928888 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,15447877 0,19278414 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,15447877 0,1926796 ! vesicle targeting GO:0006903 32 23 0,000 0,15447877 0,19257516 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,15447877 0,19247084 ! osteoblast differentiation GO:0001649 40 23 0,000 0,15447877 0,19236664 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,15447877 0,19226254 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,15447877 0,19215856 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,15447877 0,19205469 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,15447877 0,19195093 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,15447877 0,19184729 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,15447877 0,19174375 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,15447877 0,19164033 ! cell fate determination GO:0001709 45 23 0,000 0,15447877 0,19153702 ! pentose metabolic process GO:0019321 31 23 0,000 0,15447877 0,19143382 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,15447877 0,19133074 ! spermatid development GO:0007286 33 23 0,000 0,15447877 0,19122776 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,15447877 0,19112489 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,15447877 0,19102214 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,15447877 0,19091949 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,15447877 0,19081696 ! telomere organization GO:0032200 32 23 0,000 0,15447877 0,19071453 GO:0000723|telomere maintenance, ! regulation of amine transport GO:0051952 38 23 0,000 0,15447877 0,19061222 ! liver development GO:0001889 40 23 0,000 0,15447877 0,19051001 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,16062925 0,19798889 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,16062925 0,19788285 ! initiation of viral infection GO:0019059 42 24 0,000 0,16062925 0,19777691 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,16062925 0,19767109 ! superoxide metabolic process GO:0006801 32 24 0,000 0,16062925 0,19756539 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,16062925 0,19745979 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,16062925 0,19735431 ! fat cell differentiation GO:0045444 37 24 0,000 0,16062925 0,19724895 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,16062925 0,19714369 ! sperm motility GO:0030317 27 24 0,000 0,16062925 0,19703855 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,16062925 0,19693352 ! vacuole organization GO:0007033 39 24 0,000 0,16062925 0,1968286 ! neural crest cell development GO:0014032 39 24 0,000 0,16062925 0,19672379 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,16062925 0,19661909 ! primary neural tube formation GO:0014020 35 24 0,000 0,16062925 0,19651451 ! negative regulation of cell development GO:0010721 56 24 0,000 0,16062925 0,19641003 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,16062925 0,19630567 ! base-excision repair GO:0006284 31 24 0,000 0,16062925 0,19620142 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,16062925 0,19609728 ! glutathione metabolic process GO:0006749 29 24 0,000 0,16062925 0,19599325 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,16062925 0,19588933 ! regulation of translation GO:0006417 151 100 1,000 0,16441508 0,20039994 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 1,000 0,16441508 0,20029379 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,16441508 0,20018776 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,16441508 0,20008184 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,16441508 0,19997604 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,16673534 0,20269095 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,16673534 0,20258388 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,16673534 0,20247692 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,16673534 0,20237007 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,16673534 0,20226333 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,16673534 0,20215671 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,16673534 0,2020502 ! peptide transport GO:0015833 43 25 0,000 0,16673534 0,2019438 ! male gonad development GO:0008584 33 25 0,000 0,16673534 0,20183751 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,16673534 0,20173134 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,16673534 0,20162528 ! phospholipid transport GO:0015914 35 25 0,000 0,16673534 0,20151933 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,16673534 0,20141349 ! detection of light stimulus GO:0009583 30 25 0,000 0,16673534 0,20130776 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,16673534 0,20120214 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,16673534 0,20109663 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,17279735 0,2082987 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,17279735 0,20818958 ! translational initiation GO:0006413 43 26 0,000 0,17279735 0,20808058 ! regulation of pH GO:0006885 36 26 0,000 0,17279735 0,2079717 ! circadian rhythm GO:0007623 42 26 0,000 0,17279735 0,20786293 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,17279735 0,20775427 ! post-embryonic development GO:0009791 42 26 0,000 0,17279735 0,20764572 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,17279735 0,20753729 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,17279735 0,20742897 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,17279735 0,20732077 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,17279735 0,20721268 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,17279735 0,2071047 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,17279735 0,20699683 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,17279735 0,20688908 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,17279735 0,20678143 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,17881561 0,21387203 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,17881561 0,21376087 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,17881561 0,21364982 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,17881561 0,21353889 ! membrane docking GO:0022406 39 27 0,000 0,17881561 0,21342808 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,17881561 0,21331738 ! catechol metabolic process GO:0009712 43 27 0,000 0,17881561 0,2132068 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,17881561 0,21309633 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,17881561 0,21298597 ! myofibril assembly GO:0030239 36 27 0,000 0,17881561 0,21287573 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,17881561 0,2127656 ! response to ionizing radiation GO:0010212 47 27 0,000 0,17881561 0,21265559 ! natural killer cell activation GO:0030101 35 27 0,000 0,17881561 0,21254569 ! lipid oxidation GO:0034440 38 27 0,000 0,17881561 0,2124359 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,17881561 0,21232623 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,17881561 0,21221667 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,18479043 0,21919442 ! phenol metabolic process GO:0018958 44 28 0,000 0,18479043 0,21908144 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,18479043 0,21896857 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,18479043 0,21885581 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,18479043 0,21874317 ! cell junction assembly GO:0034329 56 28 0,000 0,18479043 0,21863065 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,18479043 0,21851825 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,18479043 0,21840595 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,18479043 0,21829378 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,18479043 0,21818172 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,18479043 0,21806977 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,18479043 0,21795794 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,18479043 0,21784623 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,18479043 0,21773462 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,18479043 0,21762314 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,18479043 0,21751176 ! mesoderm formation GO:0001707 46 28 0,000 0,18479043 0,21740051 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,18479043 0,21728936 ! ensheathment of neurons GO:0007272 43 28 0,000 0,18479043 0,21717833 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,18479043 0,21706741 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,18479043 0,2169566 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,18479043 0,21684591 ! neural tube formation GO:0001841 41 28 0,000 0,18479043 0,21673533 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,18479043 0,21662487 ! placenta development GO:0001890 37 28 0,000 0,18479043 0,21651451 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,19072211 0,22335074 ! regulation of innate immune response GO:0045088 38 29 0,000 0,19072211 0,22323708 ! ovulation cycle process GO:0022602 41 29 0,000 0,19072211 0,22312353 ! protein targeting to membrane GO:0006612 53 29 0,000 0,19072211 0,2230101 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,19072211 0,22289678 ! mismatch repair GO:0006298 34 29 0,000 0,19072211 0,22278358 ! muscle cell development GO:0055001 38 29 0,000 0,19072211 0,22267049 ! formation of primary germ layer GO:0001704 48 29 0,000 0,19072211 0,22255751 ! telencephalon development GO:0021537 52 29 0,000 0,19072211 0,22244466 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,19072211 0,22233191 ! eye morphogenesis GO:0048592 51 29 0,000 0,19072211 0,22221928 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,19072211 0,22210677 ! tissue homeostasis GO:0001894 42 29 0,000 0,19072211 0,22199436 GO:0048871|multicellular organismal homeostasis, ! collagen metabolic process GO:0032963 40 30 0,000 0,19661097 0,22873305 ! organic anion transport GO:0015711 51 30 0,000 0,19661097 0,22861741 ! cholesterol transport GO:0030301 46 30 0,000 0,19661097 0,22850189 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,19661097 0,22838649 ! spliceosome assembly GO:0000245 49 30 0,000 0,19661097 0,2282712 ! spindle organization GO:0007051 37 30 0,000 0,19661097 0,22815603 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,19661097 0,22804097 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,19661097 0,22792603 ! ceramide metabolic process GO:0006672 43 30 0,000 0,19661097 0,2278112 ! ovulation cycle GO:0042698 43 30 0,000 0,19661097 0,2276965 ! hindbrain development GO:0030902 45 30 0,000 0,19661097 0,2275819 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,19661097 0,22746743 ! adult locomotory behavior GO:0008344 47 30 0,000 0,19661097 0,22735306 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,19661097 0,22723881 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,19661097 0,22712468 ! response to heat GO:0009408 41 30 0,000 0,19661097 0,22701066 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,19661097 0,22689676 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,20245732 0,2335265 ! mammary gland development GO:0030879 57 31 0,000 0,20245732 0,23340944 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,20245732 0,2332925 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,20245732 0,23317568 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,20245732 0,23305898 ! odontogenesis GO:0042476 50 31 0,000 0,20245732 0,23294239 ! segmentation GO:0035282 41 31 0,000 0,20245732 0,23282592 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,20245732 0,23270956 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,20245732 0,23259332 ! metanephros development GO:0001656 58 31 0,000 0,20245732 0,2324772 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,20245732 0,23236119 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,20245732 0,2322453 ! cell fate specification GO:0001708 37 31 0,000 0,20245732 0,23212953 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,20245732 0,23201387 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,20245732 0,23189832 ! RNA modification GO:0009451 40 31 0,000 0,20245732 0,23178289 ! regulation of muscle development GO:0048634 48 32 0,000 0,20826145 0,23830912 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,20826145 0,23819062 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,20826145 0,23807224 ! meiosis I GO:0007127 52 32 0,000 0,20826145 0,23795397 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,20826145 0,23783582 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,20826145 0,23771779 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,20826145 0,23759987 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,20826145 0,23748207 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,20826145 0,23736439 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,20826145 0,23724683 ! vesicle localization GO:0051648 47 32 0,000 0,20826145 0,23712938 ! RNA export from nucleus GO:0006405 44 33 0,000 0,21402368 0,24356974 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,21402368 0,24344928 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,21402368 0,24332894 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,21402368 0,24320872 ! sister chromatid segregation GO:0000819 46 33 0,000 0,21402368 0,24308862 ! actomyosin structure organization GO:0031032 43 33 0,000 0,21402368 0,24296863 ! cell junction organization GO:0034330 63 33 0,000 0,21402368 0,24284877 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,21402368 0,24272902 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,21402368 0,24260939 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,21402368 0,24248988 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,21402368 0,24237048 ! female gonad development GO:0008585 49 33 0,000 0,21402368 0,24225121 ! positive regulation of cell development GO:0010720 54 33 0,000 0,21402368 0,24213205 ! lipid homeostasis GO:0055088 55 33 0,000 0,21402368 0,24201301 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,21402368 0,24189408 ! regulation of proteolysis GO:0030162 50 33 0,000 0,21402368 0,24177527 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,21402368 0,24165658 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,21402368 0,241538 ! cytokinesis GO:0000910 52 33 0,000 0,21402368 0,24141955 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,21402368 0,2413012 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,21974429 0,24762953 ! mRNA catabolic process GO:0006402 48 34 0,000 0,21974429 0,24750826 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,21974429 0,24738711 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,21974429 0,24726608 ! feeding behavior GO:0007631 45 34 0,000 0,21974429 0,24714517 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,21974429 0,24702437 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,21974429 0,2469037 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,21974429 0,24678314 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,21974429 0,2466627 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,21974429 0,24654237 ! neuron migration GO:0001764 46 34 0,000 0,21974429 0,24642217 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,21974429 0,24630208 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,21974429 0,24618211 ! polyol metabolic process GO:0019751 44 34 0,000 0,21974429 0,24606225 ! aerobic respiration GO:0009060 47 34 0,000 0,21974429 0,24594251 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,21974429 0,24582289 ! embryonic organ development GO:0048568 45 34 0,000 0,21974429 0,24570339 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,21974429 0,245584 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,22542359 0,25180877 ! Notch signaling pathway GO:0007219 56 35 0,000 0,22542359 0,25168653 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,22542359 0,25156442 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,22542359 0,25144242 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,22542359 0,25132053 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,22542359 0,25119877 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,22542359 0,25107712 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,22542359 0,2509556 ! glycogen metabolic process GO:0005977 48 35 0,000 0,22542359 0,25083419 ! pigment metabolic process GO:0042440 61 35 0,000 0,22542359 0,25071289 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,23106188 0,25685951 ! organic ether metabolic process GO:0018904 46 36 0,000 0,23106188 0,25673542 ! tissue remodeling GO:0048771 62 36 0,000 0,23106188 0,25661145 ! neural tube development GO:0021915 50 36 0,000 0,23106188 0,25648761 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,23106188 0,25636388 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,23106188 0,25624027 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,23106188 0,25611678 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,23106188 0,25599341 ! glucan metabolic process GO:0044042 49 36 0,000 0,23106188 0,25587016 GO:0006073|cellular glucan metabolic process, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,23665945 0,2619426 ! learning GO:0007612 67 37 0,000 0,23665945 0,26181661 ! ion transmembrane transport GO:0034220 56 37 0,000 0,23665945 0,26169073 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,23665945 0,26156498 ! amino acid activation GO:0043038 52 37 0,000 0,23665945 0,26143935 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,23665945 0,26131384 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,24221658 0,26732156 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,24221658 0,26719335 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,24221658 0,26706526 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,24221658 0,2669373 ! phagocytosis GO:0006909 60 38 0,000 0,24221658 0,26680945 ! mesenchymal cell development GO:0014031 64 38 0,000 0,24221658 0,26668173 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,24773358 0,27262547 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,24773358 0,27249509 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,24773358 0,27236483 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,24773358 0,2722347 ! male sex differentiation GO:0046661 53 39 0,000 0,24773358 0,2721047 ! chromatin remodeling GO:0006338 68 39 0,000 0,24773358 0,27197481 ! JNK cascade GO:0007254 54 39 0,000 0,24773358 0,27184505 ! developmental growth GO:0048589 62 39 0,000 0,24773358 0,27171542 ! cell growth GO:0016049 61 39 0,000 0,24773358 0,27158591 ! synapse organization GO:0050808 55 39 0,000 0,24773358 0,27145652 ! response to calcium ion GO:0051592 58 40 0,000 0,25321072 0,27732603 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,25321072 0,27719403 ! regulation of tube size GO:0035150 60 40 0,000 0,25321072 0,27706216 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,25321072 0,27693042 ! peptide metabolic process GO:0006518 56 40 0,000 0,25321072 0,2767988 ! inner ear development GO:0048839 57 40 0,000 0,25321072 0,2766673 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,25321072 0,27653593 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,25321072 0,27640468 ! double-strand break repair GO:0006302 67 40 0,000 0,25321072 0,27627356 ! B cell differentiation GO:0030183 62 40 0,000 0,25321072 0,27614256 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,2586483 0,28193891 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,2586483 0,28180535 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,2586483 0,28167192 ! glucose transport GO:0015758 52 41 0,000 0,2586483 0,28153862 ! striated muscle contraction GO:0006941 62 41 0,000 0,2586483 0,28140544 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,2586483 0,28127239 ! mitochondrial transport GO:0006839 60 42 0,000 0,2640466 0,28700717 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,2640466 0,2868716 ! hexose transport GO:0008645 54 42 0,000 0,2640466 0,28673615 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,2640466 0,28660084 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,2640466 0,28646565 ! excretion GO:0007588 63 42 0,000 0,2640466 0,28633059 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,2640466 0,28619565 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,2640466 0,28606085 ! regulation of cell shape GO:0008360 78 42 0,000 0,2640466 0,28592617 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,26940589 0,29159226 ! leukocyte migration GO:0050900 60 43 0,000 0,26940589 0,2914551 ! neuromuscular process GO:0050905 79 43 0,000 0,26940589 0,29131808 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,26940589 0,29118118 ! tRNA processing GO:0008033 49 43 0,000 0,26940589 0,29104441 ! vesicle organization GO:0016050 79 43 0,000 0,26940589 0,29090777 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,26940589 0,29077126 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,27472646 0,2963747 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,27472646 0,29623575 ! regulation of action potential GO:0001508 71 44 0,000 0,27472646 0,29609694 ! regulation of ion transport GO:0043269 57 44 0,000 0,27472646 0,29595825 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,27472646 0,29581969 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,27472646 0,29568127 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,27472646 0,29554297 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,27472646 0,2954048 ! RNA catabolic process GO:0006401 64 45 0,000 0,28000859 0,30094381 ! positive regulation of defense response GO:0031349 59 45 0,000 0,28000859 0,30080325 ! regulation of translational initiation GO:0006446 64 45 0,000 0,28000859 0,30066282 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,28000859 0,30052252 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,28000859 0,30038235 ! cell recognition GO:0008037 58 45 0,000 0,28000859 0,30024231 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,28525255 0,30572268 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,28525255 0,30558028 ! cell redox homeostasis GO:0045454 63 46 0,000 0,28525255 0,30543802 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,28525255 0,30529589 ! histone modification GO:0016570 68 46 0,000 0,28525255 0,30515389 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,29045861 0,31057871 ! viral infectious cycle GO:0019058 71 47 0,000 0,29045861 0,31043439 ! covalent chromatin modification GO:0016569 75 47 0,000 0,29045861 0,3102902 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,29045861 0,31014615 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,29045861 0,31000223 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,29562705 0,31537209 ! response to temperature stimulus GO:0009266 62 48 0,000 0,29562705 0,31522588 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,29562705 0,31507981 ! gastrulation GO:0007369 73 48 0,000 0,29562705 0,31493387 ! heart morphogenesis GO:0003007 65 48 0,000 0,29562705 0,31478807 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,29562705 0,3146424 ! regulation of endocytosis GO:0030100 63 48 0,000 0,29562705 0,31449687 ! nuclear export GO:0051168 69 48 0,000 0,29562705 0,31435147 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,29562705 0,3142062 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,30075814 0,31951211 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,30075814 0,3193646 ! sensory perception of smell GO:0007608 61 49 0,000 0,30075814 0,31921722 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,30075814 0,31906998 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,30075814 0,31892288 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,30075814 0,31877591 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,30075814 0,31862908 ! cartilage development GO:0051216 70 49 0,000 0,30075814 0,31848238 ! membrane fusion GO:0006944 80 50 0,000 0,30585214 0,32372753 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,30585214 0,32357862 ! proton transport GO:0015992 75 50 0,000 0,30585214 0,32342985 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,30585214 0,32328121 ! positive regulation of secretion GO:0051047 71 51 0,000 0,31090932 0,32847563 ! hydrogen transport GO:0006818 77 51 0,000 0,31090932 0,32832481 ! adult behavior GO:0030534 80 51 0,000 0,31090932 0,32817413 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,31090932 0,3280236 ! transition metal ion transport GO:0000041 74 52 0,000 0,31592995 0,33316776 ! aging GO:0007568 79 52 0,000 0,31592995 0,33301507 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,31592995 0,33286252 ! establishment of organelle localization GO:0051656 85 52 0,000 0,31592995 0,33271011 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,32091428 0,3378045 ! kidney development GO:0001822 90 53 0,000 0,32091428 0,33764997 ! single fertilization GO:0007338 59 53 0,000 0,32091428 0,33749558 ! amino acid transport GO:0006865 84 54 0,000 0,32586258 0,34254293 ! regulation of mitosis GO:0007088 84 54 0,000 0,32586258 0,34238644 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 76 55 0,000 0,3307751 0,34738937 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,3307751 0,34723082 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,3307751 0,34707241 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,3356521 0,35202911 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,3356521 0,35186866 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,3356521 0,35170836 ! carbohydrate transport GO:0008643 74 57 0,000 0,34049385 0,35661924 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,34049385 0,35645692 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,34049385 0,35629474 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,34049385 0,35613272 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,34049385 0,35597084 ! camera-type eye development GO:0043010 88 57 0,000 0,34049385 0,35580911 ! secondary metabolic process GO:0019748 84 57 0,000 0,34049385 0,35564752 ! gonad development GO:0008406 79 57 0,000 0,34049385 0,35548608 ! viral reproductive process GO:0022415 87 58 0,000 0,34530058 0,36034089 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,35007255 0,36515504 ! lung development GO:0030324 94 59 0,000 0,35007255 0,36498951 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,35007255 0,36482413 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,35007255 0,3646589 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,35481001 0,36942645 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,35481001 0,36925928 ! regulation of heart contraction GO:0008016 91 60 0,000 0,35481001 0,36909227 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,35481001 0,36892542 ! fertilization GO:0009566 68 60 0,000 0,35481001 0,36875871 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,35951321 0,37347804 ! urogenital system development GO:0001655 101 61 0,000 0,35951321 0,37330943 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,35951321 0,37314096 ! extracellular matrix organization GO:0030198 103 61 0,000 0,35951321 0,37297266 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,36418239 0,3776463 ! respiratory tube development GO:0030323 99 62 0,000 0,36418239 0,37747611 ! viral reproduction GO:0016032 92 63 0,000 0,3688178 0,38210853 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,37341968 0,38670205 ! appendage morphogenesis GO:0035107 93 64 0,000 0,37341968 0,38652802 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,37341968 0,38635414 ! respiratory system development GO:0060541 100 64 0,000 0,37341968 0,38618042 ! reproductive structure development GO:0048608 90 65 0,000 0,37798827 0,39072945 ! appendage development GO:0048736 94 65 0,000 0,37798827 0,39055392 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,37798827 0,39037854 ! antigen processing and presentation GO:0019882 96 66 0,000 0,38252381 0,39488544 ! axon guidance GO:0007411 99 66 0,000 0,38252381 0,39470828 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,38702653 0,39917535 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,38702653 0,39899643 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,39149668 0,403424 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,39149668 0,40324334 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,39149668 0,40306283 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,39149668 0,40288249 ! rhythmic process GO:0048511 105 68 0,000 0,39149668 0,40270231 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,39593449 0,40708508 ! response to metal ion GO:0010038 103 70 0,000 0,40034018 0,41143093 ! eye development GO:0001654 111 70 0,000 0,40034018 0,41124717 ! amine transport GO:0015837 101 70 0,000 0,40034018 0,41106358 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,40471399 0,41536911 ! muscle cell differentiation GO:0042692 104 71 0,000 0,40471399 0,41518384 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,40471399 0,41499874 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,40471399 0,4148138 ! response to hypoxia GO:0001666 132 72 0,000 0,40905615 0,41907757 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,40905615 0,41889098 ! regulation of blood pressure GO:0008217 107 73 0,000 0,41336688 0,42311697 ! tube morphogenesis GO:0035239 118 73 0,000 0,41336688 0,42292875 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,41336688 0,4227407 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,41764642 0,42692745 ! response to oxygen levels GO:0070482 137 74 0,000 0,41764642 0,42673779 ! digestion GO:0007586 97 74 0,000 0,41764642 0,42654829 ! response to inorganic substance GO:0010035 115 75 0,000 0,42189497 0,43069616 ! response to nutrient GO:0007584 104 75 0,000 0,42189497 0,43050508 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,42189497 0,43031416 ! amine biosynthetic process GO:0009309 97 76 0,000 0,42611278 0,43442349 ! tRNA metabolic process GO:0006399 95 76 0,000 0,42611278 0,43423101 ! response to unfolded protein GO:0006986 99 76 0,000 0,42611278 0,4340387 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,42611278 0,43384657 ! gland development GO:0048732 148 77 0,000 0,43030005 0,43791598 ! sex differentiation GO:0007548 105 77 0,000 0,43030005 0,4377223 ! protein ubiquitination GO:0016567 125 77 0,000 0,43030005 0,43752879 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,43030005 0,43733545 ! cellular respiration GO:0045333 107 79 0,000 0,43858388 0,44555783 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,43858388 0,44536111 ! chromatin assembly GO:0031497 102 80 0,000 0,44268086 0,44932303 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,44268086 0,44912483 ! forebrain development GO:0030900 131 80 0,000 0,44268086 0,4489268 ! mRNA transport GO:0051028 121 81 0,000 0,44674819 0,45285184 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,44674819 0,45265235 ! vitamin metabolic process GO:0006766 103 81 0,000 0,44674819 0,45245303 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,45479469 0,46039955 ! regulation of defense response GO:0031347 117 84 0,000 0,45877429 0,46422387 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,45877429 0,46401973 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,46272507 0,46780996 ! rRNA metabolic process GO:0016072 107 85 0,000 0,46272507 0,46760442 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,46272507 0,46739906 ! nucleosome organization GO:0034728 114 87 0,000 0,47054099 0,47508528 ! cellular defense response GO:0006968 102 87 0,000 0,47054099 0,47487682 ! female pregnancy GO:0007565 130 87 0,000 0,47054099 0,47466854 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,47054099 0,47446045 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,47440654 0,47814858 ! establishment of RNA localization GO:0051236 128 88 0,000 0,47440654 0,47793914 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! regulation of neurogenesis GO:0050767 153 89 0,000 0,47824409 0,48159432 ! leukocyte differentiation GO:0002521 143 90 0,000 0,48205385 0,48521831 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,48205385 0,48500606 ! hormone metabolic process GO:0042445 121 90 0,000 0,48205385 0,48479399 ! RNA localization GO:0006403 135 91 0,000 0,485836 0,48838409 ! DNA recombination GO:0006310 146 92 0,000 0,48959074 0,49194352 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,49331829 0,49547252 ! electron transport chain GO:0022900 123 94 0,000 0,49701882 0,49897132 ! angiogenesis GO:0001525 149 95 0,000 0,50069254 0,50244016 ! carboxylic acid transport GO:0046942 147 95 0,000 0,50069254 0,50222104 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,50433963 0,50565874 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,50433963 0,50543841 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,50433963 0,50521827 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,5079603 0,50862372 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! extracellular structure organization GO:0043062 156 99 0,000 0,51512309 0,51557141 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,51512309 0,51534716 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,5186656 0,5186656