pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/596-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 1,01E-06 2,324E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 2,157E-06 2,48E-03 ! isoprenoid biosynthetic process GO:0008299 21 15 2,000 8,101E-06 6,211E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 1,044E-05 6,006E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 1,632E-05 7,505E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 1,749E-05 6,704E-03 ! negative regulation of transferase activity GO:0051348 105 61 3,000 2,139E-05 7,027E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 2,341E-05 6,731E-03 ! cholesterol biosynthetic process GO:0006695 29 21 2,000 2,341E-05 5,983E-03 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 3,000 3,692E-05 8,491E-03 ! sterol biosynthetic process GO:0016126 40 28 2,000 5,691E-05 0,0119001 ! regulation of B cell activation GO:0050864 42 28 2,000 5,691E-05 0,01090842 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 7,038E-05 0,01245217 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 7,038E-05 0,01156273 ! transcription initiation GO:0006352 118 85 3,000 7,916E-05 0,01213712 ! isoprenoid metabolic process GO:0006720 46 34 2,000 1,028E-04 0,01477603 ! neuron apoptosis GO:0051402 8 6 1,000 1,054E-04 0,01425887 ! coenzyme A metabolic process GO:0015936 9 6 1,000 1,054E-04 0,01346672 ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,054E-04 0,01275794 ! response to light stimulus GO:0009416 153 96 3,000 1,271E-04 0,01461539 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 3,000 1,323E-04 0,01448962 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 1,678E-04 0,01754323 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,961E-04 0,0196057 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,961E-04 0,01878879 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,961E-04 0,01803724 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 1,000 1,961E-04 0,0173435 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 2,233E-04 0,01901771 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 2,233E-04 0,0183385 ! regulation of activated T cell proliferation GO:0046006 15 9 1,000 2,516E-04 0,01995774 ! response to UV GO:0009411 75 46 2,000 2,549E-04 0,01954418 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 2,000 2,718E-04 0,02016528 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 2,718E-04 0,01953512 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! RNA elongation GO:0006354 62 49 2,000 3,077E-04 0,02144291 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 3,14E-04 0,021242 ! T cell homeostasis GO:0043029 20 11 1,000 3,831E-04 0,02517743 ! germ cell migration GO:0008354 18 11 1,000 3,831E-04 0,02447806 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 3,831E-04 0,02381649 GO:0042130|negative regulation of T cell proliferation, ! DNA catabolic process GO:0006308 67 54 2,000 4,103E-04 0,02483501 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 4,813E-04 0,02838471 ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 5,415E-04 0,03113593 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 5,415E-04 0,03037652 ! lymphocyte homeostasis GO:0002260 24 13 1,000 5,415E-04 0,02965327 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 6,307E-04 0,03373305 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 6,307E-04 0,03296639 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 6,307E-04 0,0322338 ! lipid phosphorylation GO:0046834 23 15 1,000 7,264E-04 0,03632199 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 7,264E-04 0,03554919 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 7,264E-04 0,03480858 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! G1 phase GO:0051318 27 16 1,000 8,288E-04 0,03890264 ! steroid biosynthetic process GO:0006694 94 71 2,000 9,157E-04 0,0421237 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 9,377E-04 0,04228813 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 1,053E-03 0,04657938 ! visual learning GO:0008542 35 18 1,000 1,053E-03 0,04570053 ! negative regulation of T cell activation GO:0050868 25 18 1,000 1,053E-03 0,04485422 ! cholesterol metabolic process GO:0008203 109 77 2,000 1,159E-03 0,04846168 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 1,175E-03 0,04825805 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 1,175E-03 0,04741142 ! apoptotic nuclear changes GO:0030262 24 19 1,000 1,175E-03 0,04659398 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,175E-03 0,04580425 ! regulation of GTPase activity GO:0043087 129 80 2,000 1,294E-03 0,04961457 ! regulation of ARF GTPase activity GO:0032312 31 20 1,000 1,303E-03 0,04914074 ! positive regulation of B cell activation GO:0050871 31 20 1,000 1,303E-03 0,04834815 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 1,438E-03 0,05249924 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 1,438E-03 0,05167894 ! visual behavior GO:0007632 39 21 1,000 1,438E-03 0,05088388 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 1,438E-03 0,05011291 ! purine ribonucleoside metabolic process GO:0046128 28 21 1,000 1,438E-03 0,04936495 GO:0042278|purine nucleoside metabolic process, ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 1,438E-03 0,048639 ! sterol metabolic process GO:0016125 120 84 2,000 1,49E-03 0,04966033 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 1,579E-03 0,05188534 ! leukocyte homeostasis GO:0001776 33 22 1,000 1,579E-03 0,05115456 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 1,594E-03 0,05092387 ! interphase GO:0051325 159 88 2,000 1,703E-03 0,05365433 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 1,727E-03 0,05366314 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 1,727E-03 0,05294763 ! group transfer coenzyme metabolic process GO:0006752 28 23 1,000 1,727E-03 0,05225095 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 1,88E-03 0,05616456 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 1,88E-03 0,0554445 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 2,04E-03 0,05940117 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 2,04E-03 0,05865866 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 2,379E-03 0,06755182 ! homophilic cell adhesion GO:0007156 149 100 2,000 2,454E-03 0,06881782 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 2,558E-03 0,07087383 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 2,742E-03 0,075089 ! negative regulation of cell activation GO:0050866 44 30 1,000 2,933E-03 0,07937018 ! regulation of ARF protein signal transduction GO:0032012 51 32 1,000 3,333E-03 0,08914268 ! nucleus organization GO:0006997 49 33 1,000 3,542E-03 0,09364293 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 3,542E-03 0,09257881 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 3,757E-03 0,09709374 ! Notch signaling pathway GO:0007219 56 35 1,000 3,978E-03 0,1016602 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 3,978E-03 0,10054306 ! keratinocyte differentiation GO:0030216 47 35 1,000 3,978E-03 0,0994502 ! Rho protein signal transduction GO:0007266 51 35 1,000 3,978E-03 0,09838084 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 3,978E-03 0,09733424 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 3,978E-03 0,09630967 ! learning GO:0007612 67 37 1,000 4,438E-03 0,10631541 ! ribonucleoside metabolic process GO:0009119 48 37 1,000 4,438E-03 0,10521937 ! regulation of T cell proliferation GO:0042129 58 38 1,000 4,676E-03 0,10974406 ! cell growth GO:0016049 61 39 1,000 4,92E-03 0,11431243 ! epidermal cell differentiation GO:0009913 53 40 1,000 5,171E-03 0,11892245 ! positive regulation of protein transport GO:0051222 55 40 1,000 5,171E-03 0,117745 ! positive regulation of DNA binding GO:0043388 57 41 1,000 5,426E-03 0,12236068 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 5,688E-03 0,12701447 ! cellular component disassembly GO:0022411 64 42 1,000 5,688E-03 0,12579318 ! positive regulation of binding GO:0051099 59 43 1,000 5,955E-03 0,13045026 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 5,955E-03 0,12921959 ! response to insulin stimulus GO:0032868 63 43 1,000 5,955E-03 0,12801193 ! negative regulation of immune system process GO:0002683 73 47 1,000 7,081E-03 0,15079487 ! regulation of DNA replication GO:0006275 75 48 1,000 7,376E-03 0,15564211 ! regulation of intracellular transport GO:0032386 78 49 1,000 7,677E-03 0,1605163 ! lipid modification GO:0030258 73 50 1,000 7,983E-03 0,16541609 ! nucleotide-excision repair GO:0006289 64 52 1,000 8,612E-03 0,17685233 ! nucleoside metabolic process GO:0009116 69 55 1,000 9,595E-03 0,19530587 ! gonad development GO:0008406 79 57 1,000 0,01027766 0,20735633 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,01062663 0,21253256 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,01134015 0,22484774 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,01170464 0,23009123 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,01207425 0,2353456 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,01244895 0,24061002 ! negative regulation of cell size GO:0045792 108 64 1,000 0,01282871 0,24588368 ! reproductive structure development GO:0048608 90 65 1,000 0,01321351 0,2511658 ! regulation of caspase activity GO:0043281 97 65 1,000 0,01321351 0,24910707 ! protein oligomerization GO:0051259 100 65 1,000 0,01321351 0,24708181 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01337183 0,24802596 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01337183 0,24604175 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01337183 0,24408904 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01337183 0,24216708 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01337183 0,24027515 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01337183 0,23841255 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01337183 0,23657861 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01337183 0,23477266 ! sleep GO:0030431 11 5 0,000 0,01337183 0,23299408 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01337183 0,23124225 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01337183 0,22951656 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01337183 0,22781644 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01337183 0,22614132 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01337183 0,22449065 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01337183 0,22286391 ! tongue development GO:0043586 6 5 0,000 0,01337183 0,22126057 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01337183 0,21968014 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01337183 0,21812212 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01337183 0,21658605 ! cobalt ion transport GO:0006824 9 5 0,000 0,01337183 0,21507146 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01337183 0,21357791 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01337183 0,21210496 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01337183 0,21065219 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01337183 0,20921918 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01337183 0,20780553 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01337183 0,20641087 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01337183 0,20503479 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01337183 0,20367695 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01337183 0,20233697 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01337183 0,2010145 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01337183 0,19970921 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01337183 0,19842077 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01337183 0,19714884 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01337183 0,19589312 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01337183 0,19465329 ! malate metabolic process GO:0006108 7 5 0,000 0,01337183 0,19342905 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01337183 0,19222012 ! behavioral response to pain GO:0048266 7 5 0,000 0,01337183 0,19102621 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01337183 0,18984703 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01337183 0,18868233 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01337183 0,18753182 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01337183 0,18639527 ! mating behavior GO:0007617 6 5 0,000 0,01337183 0,1852724 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01337183 0,18416299 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01337183 0,18306678 ! rhythmic behavior GO:0007622 12 5 0,000 0,01337183 0,18198354 ! copulation GO:0007620 7 5 0,000 0,01337183 0,18091305 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01337183 0,17985508 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01337183 0,17880941 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01337183 0,17777583 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01337183 0,17675413 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01337183 0,17574411 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01337183 0,17474556 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01337183 0,1737583 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01337183 0,17278213 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01337183 0,17181687 ! response to protozoan GO:0001562 9 5 0,000 0,01337183 0,17086233 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,01337183 0,16991834 ! lymph vessel development GO:0001945 7 5 0,000 0,01337183 0,16898472 ! endochondral ossification GO:0001958 12 5 0,000 0,01337183 0,16806131 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01337183 0,16714793 ! parathyroid gland development GO:0060017 8 5 0,000 0,01337183 0,16624443 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01337183 0,16535064 ! anagen GO:0042640 6 5 0,000 0,01337183 0,16446641 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01337183 0,16359159 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01337183 0,16272603 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01337183 0,16186957 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01337183 0,16102209 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01337183 0,16018343 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01337183 0,15935347 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01337183 0,15853206 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01337183 0,15771907 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01337183 0,15691438 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01337183 0,15611786 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01337183 0,15532939 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01337183 0,15454884 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01337183 0,1537761 ! ovulation GO:0030728 6 5 0,000 0,01337183 0,15301104 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01337183 0,15225356 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01337183 0,15150354 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01337183 0,15076088 ! response to pH GO:0009268 9 5 0,000 0,01337183 0,15002546 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01337183 0,14929718 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01337183 0,14857594 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01337183 0,14786163 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01337183 0,14715416 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01337183 0,14645342 ! polyol catabolic process GO:0046174 7 5 0,000 0,01337183 0,14575933 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01337183 0,14507179 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01337183 0,1443907 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01337183 0,14371598 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01337183 0,14304753 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01337183 0,14238527 ! urea metabolic process GO:0019627 6 5 0,000 0,01337183 0,14172912 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01337183 0,14107899 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01337183 0,14043479 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01337183 0,13979645 ! neutrophil activation GO:0042119 5 5 0,000 0,01337183 0,13916389 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01337183 0,13853702 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01337183 0,13791578 ! response to food GO:0032094 5 5 0,000 0,01337183 0,13730009 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01337183 0,13668986 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01337183 0,13608504 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01337183 0,13548555 ! forebrain neuron development GO:0021884 7 5 0,000 0,01337183 0,13489131 ! melanosome organization GO:0032438 7 5 0,000 0,01337183 0,13430227 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01337183 0,13371834 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01337183 0,13313948 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01337183 0,1325656 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01337183 0,13199665 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01337183 0,13143256 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01337183 0,13087327 ! nucleoside transport GO:0015858 6 5 0,000 0,01337183 0,13031872 ! nucleoside salvage GO:0043174 7 5 0,000 0,01337183 0,12976886 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01337183 0,12922361 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01337183 0,12868292 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01337183 0,12814675 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01337183 0,12761502 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01337183 0,12708768 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01337183 0,12656469 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01337183 0,12604598 ! depyrimidination GO:0045008 8 5 0,000 0,01337183 0,12553151 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01337183 0,12502122 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01337183 0,12451506 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01337183 0,12401298 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01337183 0,12351494 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01337183 0,12302088 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01337183 0,12253075 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01337183 0,12204452 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01337183 0,12156213 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01337183 0,12108354 ! monocyte differentiation GO:0030224 8 5 0,000 0,01337183 0,1206087 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01337183 0,12013757 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01337183 0,11967011 ! centrosome duplication GO:0051298 5 5 0,000 0,01337183 0,11920628 ! response to UV-C GO:0010225 6 5 0,000 0,01337183 0,11874602 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01337183 0,1182893 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01337183 0,11783609 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01337183 0,11738633 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01337183 0,11694 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01337183 0,11649704 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01337183 0,11605743 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01337183 0,11562112 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01337183 0,11518809 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01337183 0,11475828 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01337183 0,11433167 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01337183 0,11390822 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01337183 0,11348789 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01337183 0,11307066 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01337183 0,11265648 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01337183 0,11224533 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01337183 0,11183716 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01337183 0,11143195 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01337183 0,11102967 ! neural tube patterning GO:0021532 6 5 0,000 0,01337183 0,11063028 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01337183 0,11023376 ! histone demethylation GO:0016577 9 5 0,000 0,01337183 0,10984007 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01337183 0,10944918 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01337183 0,10906106 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01337183 0,10867569 ! enteric nervous system development GO:0048484 8 5 0,000 0,01337183 0,10829302 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01337183 0,10791305 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01337183 0,10753573 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01337183 0,10716104 ! transcription termination GO:0006353 8 5 0,000 0,01337183 0,10678896 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01337183 0,10641944 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01337183 0,10605248 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01337183 0,10568804 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,01337183 0,10532609 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01337183 0,10496662 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01337183 0,10460959 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01337183 0,10425498 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01337183 0,10390277 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01337183 0,10355293 ! apical protein localization GO:0045176 6 5 0,000 0,01337183 0,10320543 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01337183 0,10286026 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01337183 0,1025174 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01337183 0,10217681 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01337183 0,10183847 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01337183 0,10150237 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01337183 0,10116848 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01337183 0,10083678 ! glial cell migration GO:0008347 10 5 0,000 0,01337183 0,10050725 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01337183 0,10017987 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01337183 0,09985461 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01337183 0,09953145 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01337183 0,09921038 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01337183 0,09889138 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01337183 0,09857442 ! neural plate development GO:0001840 6 5 0,000 0,01337183 0,09825949 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01337183 0,09794656 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01337183 0,09763562 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01337183 0,09732664 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01337183 0,09701962 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01337183 0,09671453 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01337183 0,09641135 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01337183 0,09611006 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01337183 0,09581065 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01337183 0,0955131 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01337183 0,0952174 ! spindle assembly GO:0051225 5 5 0,000 0,01337183 0,09492352 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01337183 0,09463144 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01337183 0,09434116 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01337183 0,09405266 ! organ regeneration GO:0031100 7 5 0,000 0,01337183 0,09376591 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01337183 0,09348091 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01337183 0,09319763 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01337183 0,09291607 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01337183 0,0926362 GO:0055081|anion homeostasis, ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,01399807 0,09668335 ! learning or memory GO:0007611 123 68 1,000 0,01439778 0,09914641 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,01439778 0,09885045 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,01439778 0,09855625 ! response to drug GO:0042493 108 69 1,000 0,01480241 0,10102538 ! tRNA transcription GO:0009304 11 6 0,000 0,01602512 0,10904669 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01602512 0,10872502 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01602512 0,10840524 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01602512 0,10808734 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01602512 0,10777129 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01602512 0,10745709 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01602512 0,10714472 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01602512 0,10683415 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01602512 0,10652538 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01602512 0,10621839 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01602512 0,10591317 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01602512 0,10560969 ! prostate gland development GO:0030850 9 6 0,000 0,01602512 0,10530795 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01602512 0,10500793 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01602512 0,10470961 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01602512 0,10441298 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01602512 0,10411803 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01602512 0,10382474 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01602512 0,1035331 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01602512 0,10324309 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01602512 0,1029547 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01602512 0,10266792 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01602512 0,10238273 ! neuron adhesion GO:0007158 9 6 0,000 0,01602512 0,10209912 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01602512 0,10181708 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01602512 0,10153659 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01602512 0,10125764 ! signal peptide processing GO:0006465 8 6 0,000 0,01602512 0,10098023 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01602512 0,10070432 ! mRNA stabilization GO:0048255 15 6 0,000 0,01602512 0,10042993 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01602512 0,10015702 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01602512 0,09988559 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01602512 0,09961563 ! opsonization GO:0008228 8 6 0,000 0,01602512 0,09934712 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01602512 0,09908006 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01602512 0,09881443 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01602512 0,09855022 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01602512 0,09828742 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01602512 0,09802602 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01602512 0,097766 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01602512 0,09750736 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01602512 0,09725009 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01602512 0,09699417 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01602512 0,09673959 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01602512 0,09648634 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01602512 0,09623442 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01602512 0,09598381 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01602512 0,0957345 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01602512 0,09548648 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01602512 0,09523975 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01602512 0,09499429 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01602512 0,09475008 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01602512 0,09450714 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01602512 0,09426543 ! thymic T cell selection GO:0045061 12 6 0,000 0,01602512 0,09402496 ! protein lipoylation GO:0009249 10 6 0,000 0,01602512 0,09378571 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01602512 0,09354767 ! pigment granule organization GO:0048753 11 6 0,000 0,01602512 0,09331084 ! drug transport GO:0015893 6 6 0,000 0,01602512 0,09307521 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01602512 0,09284076 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01602512 0,09260749 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01602512 0,0923754 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01602512 0,09214446 ! histidine metabolic process GO:0006547 6 6 0,000 0,01602512 0,09191467 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01602512 0,09168603 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01602512 0,09145852 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01602512 0,09123214 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01602512 0,09100687 ! adenohypophysis development GO:0021984 10 6 0,000 0,01602512 0,09078272 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01602512 0,09055966 ! hyperosmotic response GO:0006972 8 6 0,000 0,01602512 0,0903377 ! microtubule nucleation GO:0007020 10 6 0,000 0,01602512 0,09011683 ! ER overload response GO:0006983 7 6 0,000 0,01602512 0,08989703 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01602512 0,0896783 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01602512 0,08946064 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01602512 0,08924403 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01602512 0,08902846 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01602512 0,08881393 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01602512 0,08860044 ! response to dietary excess GO:0002021 7 6 0,000 0,01602512 0,08838797 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01602512 0,08817651 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01602512 0,08796607 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01602512 0,08775663 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01602512 0,08754818 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01602512 0,08734072 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01602512 0,08713424 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01602512 0,08692873 ! organic alcohol transport GO:0015850 9 6 0,000 0,01602512 0,08672419 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01602512 0,08652062 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01602512 0,08631799 ! male sex determination GO:0030238 9 6 0,000 0,01602512 0,08611631 ! carnitine transport GO:0015879 8 6 0,000 0,01602512 0,08591558 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01602512 0,08571577 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01602512 0,0855169 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01602512 0,08531894 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01602512 0,0851219 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01602512 0,08492577 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01602512 0,08473053 ! parturition GO:0007567 12 6 0,000 0,01602512 0,0845362 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01602512 0,08434275 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01602512 0,08415019 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01602512 0,0839585 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01602512 0,08376769 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01602512 0,08357774 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01602512 0,08338865 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01602512 0,08320041 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01602512 0,08301302 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01602512 0,08282648 ! macrophage differentiation GO:0030225 10 6 0,000 0,01602512 0,08264077 ! astrocyte development GO:0014002 14 6 0,000 0,01602512 0,08245589 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01602512 0,08227184 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01602512 0,0820886 ! interaction with symbiont GO:0051702 8 6 0,000 0,01602512 0,08190618 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01602512 0,08172457 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01602512 0,08154377 ! eating behavior GO:0042755 6 6 0,000 0,01602512 0,08136376 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01602512 0,08118454 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01602512 0,08100612 ! response to copper ion GO:0046688 9 6 0,000 0,01602512 0,08082847 ! DNA topological change GO:0006265 8 6 0,000 0,01602512 0,0806516 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01602512 0,08047551 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01602512 0,08030018 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01602512 0,08012561 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01602512 0,07995181 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01602512 0,07977875 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01602512 0,07960644 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01602512 0,07943488 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01602512 0,07926405 ! gas homeostasis GO:0033483 11 6 0,000 0,01602512 0,07909395 ! hair follicle maturation GO:0048820 7 6 0,000 0,01602512 0,07892459 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01602512 0,07875595 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01602512 0,07858802 ! Schwann cell development GO:0014044 14 6 0,000 0,01602512 0,07842081 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01602512 0,07825432 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01602512 0,07808852 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01602512 0,07792343 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01602512 0,07775904 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01602512 0,07759533 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01602512 0,07743232 ! histone ubiquitination GO:0016574 7 6 0,000 0,01602512 0,07726998 ! regulation of meiosis GO:0040020 10 6 0,000 0,01602512 0,07710833 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01602512 0,07694735 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01602512 0,07678705 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01602512 0,07662741 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01602512 0,07646843 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01602512 0,07631011 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01602512 0,07615244 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01602512 0,07599543 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01602512 0,07583906 ! receptor internalization GO:0031623 9 6 0,000 0,01602512 0,07568333 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01602512 0,07552824 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01602512 0,07537379 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01602512 0,07521996 ! protein deubiquitination GO:0016579 8 6 0,000 0,01602512 0,07506677 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01602512 0,07491419 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01602512 0,07476224 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01602512 0,0746109 ! axonal fasciculation GO:0007413 9 6 0,000 0,01602512 0,07446017 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01602512 0,07431005 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01602512 0,07416053 ! midbrain development GO:0030901 6 6 0,000 0,01602512 0,07401161 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01602512 0,07386329 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01602512 0,07371557 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01602512 0,07356843 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01602512 0,07342188 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01602512 0,07327591 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01602512 0,07313052 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01602512 0,07298571 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01602512 0,07284147 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01602512 0,0726978 ! adult feeding behavior GO:0008343 6 6 0,000 0,01602512 0,07255469 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01602512 0,07241215 ! blastocyst growth GO:0001832 15 6 0,000 0,01602512 0,07227016 ! pigment granule transport GO:0051904 12 6 0,000 0,01602512 0,07212873 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01602512 0,07198786 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01602512 0,07184753 ! catecholamine transport GO:0051937 7 6 0,000 0,01602512 0,07170775 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01602512 0,07156851 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01602512 0,07142981 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01602512 0,07129165 ! protein prenylation GO:0018342 10 6 0,000 0,01602512 0,07115402 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01602512 0,07101692 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01602512 0,07088035 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,01602512 0,0707443 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,01602512 0,07060878 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01602512 0,07047377 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,01604553 0,07042887 ! mitochondrion organization GO:0007005 104 73 1,000 0,01646956 0,07215234 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,01689836 0,07389015 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,01689836 0,07374994 ! negative regulation of growth GO:0045926 123 75 1,000 0,01733191 0,07549883 ! response to nutrient GO:0007584 104 75 1,000 0,01733191 0,07535611 ! regulation of protein transport GO:0051223 114 76 1,000 0,01777018 0,07711587 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 1,000 0,01821315 0,07888934 ! sex differentiation GO:0007548 105 77 1,000 0,01821315 0,07874105 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,01867143 0,08057089 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01867143 0,08042001 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01867143 0,08026969 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01867143 0,08011993 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01867143 0,07997073 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01867143 0,07982209 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01867143 0,07967399 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01867143 0,07952645 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01867143 0,07937945 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01867143 0,07923299 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01867143 0,07908708 ! reproductive behavior GO:0019098 12 7 0,000 0,01867143 0,0789417 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01867143 0,07879685 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,01867143 0,07865253 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01867143 0,07850874 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,01867143 0,07836548 ! oligopeptide transport GO:0006857 11 7 0,000 0,01867143 0,07822274 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01867143 0,07808052 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01867143 0,07793881 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,01867143 0,07779761 ! RNA methylation GO:0001510 11 7 0,000 0,01867143 0,07765693 ! pericardium development GO:0060039 8 7 0,000 0,01867143 0,07751676 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01867143 0,07737709 ! fibril organization GO:0043206 13 7 0,000 0,01867143 0,07723792 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01867143 0,07709925 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01867143 0,07696108 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01867143 0,0768234 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01867143 0,07668622 ! lipoprotein transport GO:0042953 9 7 0,000 0,01867143 0,07654952 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01867143 0,07641332 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01867143 0,07627759 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01867143 0,07614235 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01867143 0,07600758 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01867143 0,07587329 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01867143 0,07573948 ! chemosensory behavior GO:0007635 9 7 0,000 0,01867143 0,07560613 ! microtubule bundle formation GO:0001578 8 7 0,000 0,01867143 0,07547326 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,01867143 0,07534085 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01867143 0,0752089 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01867143 0,07507742 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01867143 0,07494639 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01867143 0,07481582 ! reflex GO:0060004 12 7 0,000 0,01867143 0,07468571 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01867143 0,07455605 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01867143 0,07442683 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01867143 0,07429807 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01867143 0,07416975 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01867143 0,07404187 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01867143 0,07391443 ! spinal cord patterning GO:0021511 7 7 0,000 0,01867143 0,07378743 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01867143 0,07366086 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,01867143 0,07353473 ! adrenal gland development GO:0030325 17 7 0,000 0,01867143 0,07340903 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01867143 0,07328376 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01867143 0,07315892 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01867143 0,0730345 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01867143 0,0729105 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01867143 0,07278692 ! endosome organization GO:0007032 10 7 0,000 0,01867143 0,07266376 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01867143 0,07254102 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,01867143 0,07241869 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01867143 0,07229677 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01867143 0,07217527 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01867143 0,07205417 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01867143 0,07193347 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01867143 0,07181318 ! galactose metabolic process GO:0006012 10 7 0,000 0,01867143 0,07169329 ! vesicle fusion GO:0006906 15 7 0,000 0,01867143 0,07157381 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01867143 0,07145471 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01867143 0,07133602 ! organ growth GO:0035265 11 7 0,000 0,01867143 0,07121772 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,01867143 0,07109981 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,01867143 0,07098229 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01867143 0,07086515 ! retinol metabolic process GO:0042572 9 7 0,000 0,01867143 0,07074841 ! behavioral fear response GO:0001662 13 7 0,000 0,01867143 0,07063204 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,01867143 0,07051606 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01867143 0,07040046 ! rRNA modification GO:0000154 12 7 0,000 0,01867143 0,07028524 ! protein heterooligomerization GO:0051291 10 7 0,000 0,01867143 0,0701704 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01867143 0,07005593 ! response to UV-B GO:0010224 11 7 0,000 0,01867143 0,06994183 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01867143 0,0698281 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,01867143 0,06971475 ! intermediate filament organization GO:0045109 11 7 0,000 0,01867143 0,06960176 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,01867143 0,06948913 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01867143 0,06937687 ! fibrinolysis GO:0042730 9 7 0,000 0,01867143 0,06926497 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01867143 0,06915344 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01867143 0,06904226 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01867143 0,06893143 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01867143 0,06882097 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01867143 0,06871085 ! response to tropane GO:0014073 13 7 0,000 0,01867143 0,06860109 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01867143 0,06849168 ! melanosome localization GO:0032400 10 7 0,000 0,01867143 0,06838262 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01867143 0,0682739 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01867143 0,06816553 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,01867143 0,0680575 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01867143 0,06794982 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01867143 0,06784247 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01867143 0,06773546 ! mast cell activation GO:0045576 9 7 0,000 0,01867143 0,06762879 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01867143 0,06752246 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,01867143 0,06741646 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01867143 0,06731079 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01867143 0,06720545 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01867143 0,06710044 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01867143 0,06699576 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,01867143 0,06689141 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01867143 0,06678738 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01867143 0,06668367 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,01867143 0,06658028 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01867143 0,06647722 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01867143 0,06637447 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01867143 0,06627204 ! response to tumor cell GO:0002347 12 7 0,000 0,01867143 0,06616993 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01867143 0,06606813 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01867143 0,06596664 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01867143 0,06586547 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,01867143 0,0657646 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01867143 0,06566404 ! diuresis GO:0030146 12 7 0,000 0,01867143 0,06556379 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01867143 0,06546385 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01867143 0,06536421 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01867143 0,06526487 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01867143 0,06516583 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01867143 0,0650671 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01867143 0,06496866 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01867143 0,06487052 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01867143 0,06477267 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01867143 0,06467513 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01867143 0,06457787 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01867143 0,06448091 ! lymph node development GO:0048535 9 7 0,000 0,01867143 0,06438423 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01867143 0,06428785 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01867143 0,06419175 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01867143 0,06409595 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,01867143 0,06400042 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,01867143 0,06390518 ! ATP catabolic process GO:0006200 10 7 0,000 0,01867143 0,06381023 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01867143 0,06371555 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01867143 0,06362116 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,01867143 0,06352705 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01867143 0,06343321 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01867143 0,06333965 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01867143 0,06324637 ! muscle adaptation GO:0043500 12 7 0,000 0,01867143 0,06315336 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01867143 0,06306062 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01867143 0,06296816 ! retina homeostasis GO:0001895 9 7 0,000 0,01867143 0,06287596 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01867143 0,06278404 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,01867143 0,06269238 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01867143 0,062601 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,01867143 0,06250987 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01867143 0,06241902 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01867143 0,06232842 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01867143 0,06223809 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,02003143 0,06667481 GO:0002696|positive regulation of leukocyte activation, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02131077 0,07083058 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02131077 0,07072837 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,02131077 0,07062646 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02131077 0,07052484 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02131077 0,07042351 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02131077 0,07032247 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02131077 0,07022172 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02131077 0,07012126 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02131077 0,07002109 ! phosphate transport GO:0006817 10 8 0,000 0,02131077 0,0699212 ! N-glycan processing GO:0006491 12 8 0,000 0,02131077 0,0698216 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02131077 0,06972228 ! UTP metabolic process GO:0046051 8 8 0,000 0,02131077 0,06962324 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02131077 0,06952449 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02131077 0,06942601 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,02131077 0,06932781 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02131077 0,06922989 ! succinate metabolic process GO:0006105 14 8 0,000 0,02131077 0,06913225 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,02131077 0,06903488 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02131077 0,06893778 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02131077 0,06884096 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02131077 0,06874441 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,02131077 0,06864813 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02131077 0,06855211 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02131077 0,06845637 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02131077 0,0683609 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02131077 0,06826569 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02131077 0,06817074 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,02131077 0,06807606 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02131077 0,06798164 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02131077 0,06788748 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02131077 0,06779359 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02131077 0,06769995 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02131077 0,06760657 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,02131077 0,06751345 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02131077 0,06742058 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02131077 0,06732797 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02131077 0,06723561 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02131077 0,06714351 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02131077 0,06705166 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02131077 0,06696006 ! melanin metabolic process GO:0006582 12 8 0,000 0,02131077 0,06686871 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02131077 0,06677761 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02131077 0,06668675 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,02131077 0,06659614 ! macrophage activation GO:0042116 12 8 0,000 0,02131077 0,06650578 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02131077 0,06641567 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02131077 0,06632579 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,02131077 0,06623617 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02131077 0,06614678 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02131077 0,06605763 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02131077 0,06596872 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02131077 0,06588006 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02131077 0,06579163 ! ruffle organization GO:0031529 11 8 0,000 0,02131077 0,06570343 ! osteoblast development GO:0002076 13 8 0,000 0,02131077 0,06561548 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02131077 0,06552776 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02131077 0,06544027 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02131077 0,06535302 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02131077 0,06526599 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02131077 0,06517921 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02131077 0,06509265 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02131077 0,06500632 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02131077 0,06492021 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02131077 0,06483434 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02131077 0,0647487 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02131077 0,06466327 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02131077 0,06457808 ! segment specification GO:0007379 10 8 0,000 0,02131077 0,06449311 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02131077 0,06440836 ! cellular extravasation GO:0045123 11 8 0,000 0,02131077 0,06432383 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02131077 0,06423953 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02131077 0,06415545 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02131077 0,06407158 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,02131077 0,06398794 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02131077 0,06390451 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02131077 0,0638213 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,02131077 0,06373831 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02131077 0,06365554 ! nucleosome disassembly GO:0006337 12 8 0,000 0,02131077 0,06357297 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02131077 0,06349062 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02131077 0,06340849 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02131077 0,06332657 ! icosanoid secretion GO:0032309 12 8 0,000 0,02131077 0,06324485 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,02131077 0,06316335 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02131077 0,06308206 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02131077 0,06300098 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02131077 0,06292011 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02131077 0,06283944 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02131077 0,06275898 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02131077 0,06267872 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02131077 0,06259867 ! sterol catabolic process GO:0016127 9 8 0,000 0,02131077 0,06251883 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02131077 0,06243919 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02131077 0,06235975 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02131077 0,06228051 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02131077 0,06220147 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02131077 0,06212264 ! prophase GO:0051324 11 8 0,000 0,02131077 0,062044 ! S phase GO:0051320 8 8 0,000 0,02131077 0,06196557 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02131077 0,06188733 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02131077 0,06180928 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02131077 0,06173144 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02131077 0,06165379 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02131077 0,06157633 ! hormone catabolic process GO:0042447 13 8 0,000 0,02131077 0,06149907 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02131077 0,06142201 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02131077 0,06134513 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02131077 0,06126845 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02131077 0,06119196 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02131077 0,06111566 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02131077 0,06103955 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02131077 0,06096363 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02131077 0,0608879 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02131077 0,06081236 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02131077 0,060737 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02131077 0,06066183 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02131077 0,06058685 ! regulation of embryonic development GO:0045995 16 8 0,000 0,02131077 0,06051205 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02131077 0,06043744 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02131077 0,06036301 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,02131077 0,06028876 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,02192268 0,06194369 ! regulation of protein localization GO:0032880 132 85 1,000 0,02192268 0,06186769 ! cell cycle arrest GO:0007050 150 86 1,000 0,02240669 0,06315612 ! reproductive developmental process GO:0003006 127 89 1,000 0,02388519 0,06724105 ! regulation of T cell activation GO:0050863 128 89 1,000 0,02388519 0,06715885 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,02394316 0,06723963 ! regulation of developmental growth GO:0048638 13 9 0,000 0,02394316 0,06715763 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,02394316 0,06707584 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02394316 0,06699423 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,02394316 0,06691283 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02394316 0,06683163 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02394316 0,06675062 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,02394316 0,06666981 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02394316 0,06658919 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02394316 0,06650877 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02394316 0,06642854 ! GTP metabolic process GO:0046039 9 9 0,000 0,02394316 0,06634851 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02394316 0,06626867 ! social behavior GO:0035176 14 9 0,000 0,02394316 0,06618902 ! artery development GO:0060840 19 9 0,000 0,02394316 0,06610956 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02394316 0,06603029 ! regulation of glycolysis GO:0006110 15 9 0,000 0,02394316 0,06595121 ! response to pain GO:0048265 16 9 0,000 0,02394316 0,06587232 ! protein complex disassembly GO:0043241 17 9 0,000 0,02394316 0,06579362 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02394316 0,06571511 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02394316 0,06563678 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02394316 0,06555864 ! lung alveolus development GO:0048286 17 9 0,000 0,02394316 0,06548069 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02394316 0,06540292 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02394316 0,06532534 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02394316 0,06524794 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02394316 0,06517072 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02394316 0,06509369 ! protein targeting to ER GO:0045047 19 9 0,000 0,02394316 0,06501684 ! T cell selection GO:0045058 18 9 0,000 0,02394316 0,06494017 ! endoderm development GO:0007492 12 9 0,000 0,02394316 0,06486368 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02394316 0,06478737 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02394316 0,06471123 ! arginine catabolic process GO:0006527 10 9 0,000 0,02394316 0,06463528 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02394316 0,06455951 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02394316 0,06448391 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02394316 0,06440849 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02394316 0,06433325 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02394316 0,06425818 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02394316 0,06418329 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02394316 0,06410857 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02394316 0,06403402 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02394316 0,06395965 ! mannose metabolic process GO:0006013 9 9 0,000 0,02394316 0,06388545 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02394316 0,06381143 ! receptor clustering GO:0043113 15 9 0,000 0,02394316 0,06373757 ! epithelial cell development GO:0002064 10 9 0,000 0,02394316 0,06366389 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02394316 0,06359037 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02394316 0,06351702 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02394316 0,06344385 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02394316 0,06337084 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02394316 0,063298 ! motor axon guidance GO:0008045 14 9 0,000 0,02394316 0,06322533 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02394316 0,06315282 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02394316 0,06308048 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02394316 0,06300831 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02394316 0,0629363 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02394316 0,06286445 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02394316 0,06279277 ! DNA ligation GO:0006266 14 9 0,000 0,02394316 0,06272125 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02394316 0,0626499 ! response to amine stimulus GO:0014075 13 9 0,000 0,02394316 0,06257871 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02394316 0,06250767 ! erythrocyte development GO:0048821 11 9 0,000 0,02394316 0,0624368 ! renal water homeostasis GO:0003091 14 9 0,000 0,02394316 0,06236609 ! postreplication repair GO:0006301 11 9 0,000 0,02394316 0,06229554 ! mRNA cleavage GO:0006379 13 9 0,000 0,02394316 0,06222515 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02394316 0,06215492 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02394316 0,06208485 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02394316 0,06201493 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02394316 0,06194518 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02394316 0,06187557 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02394316 0,06180613 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02394316 0,06173684 ! acid secretion GO:0046717 14 9 0,000 0,02394316 0,06166771 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02394316 0,06159873 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02394316 0,0615299 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02394316 0,06146123 ! purine base metabolic process GO:0006144 18 9 0,000 0,02394316 0,06139271 ! oocyte differentiation GO:0009994 12 9 0,000 0,02394316 0,06132434 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02394316 0,06125613 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02394316 0,06118807 ! spleen development GO:0048536 15 9 0,000 0,02394316 0,06112016 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02394316 0,0610524 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02394316 0,06098478 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02394316 0,06091732 ! detection of calcium ion GO:0005513 13 9 0,000 0,02394316 0,06085001 ! blastocyst formation GO:0001825 12 9 0,000 0,02394316 0,06078285 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02394316 0,06071583 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02394316 0,06064897 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02394316 0,06058224 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02394316 0,06051567 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02394316 0,06044924 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02394316 0,06038296 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02394316 0,06031682 ! prepulse inhibition GO:0060134 14 9 0,000 0,02394316 0,06025083 ! embryonic placenta development GO:0001892 12 9 0,000 0,02394316 0,06018498 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,02394316 0,06011928 ! insulin secretion GO:0030073 17 9 0,000 0,02394316 0,06005372 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02394316 0,0599883 ! response to nicotine GO:0035094 16 9 0,000 0,02394316 0,05992303 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02394316 0,05985789 ! nucleus localization GO:0051647 15 9 0,000 0,02394316 0,0597929 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02394316 0,05972805 ! localization within membrane GO:0051668 15 9 0,000 0,02394316 0,05966334 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,02540283 0,06323216 ! cell fate commitment GO:0045165 141 92 1,000 0,02540283 0,0631638 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02656862 0,06599117 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02656862 0,06591998 ! neuron fate specification GO:0048665 11 10 0,000 0,02656862 0,06584894 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02656862 0,06577806 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02656862 0,06570733 ! thyroid gland development GO:0030878 19 10 0,000 0,02656862 0,06563676 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02656862 0,06556633 ! synapsis GO:0007129 13 10 0,000 0,02656862 0,06549606 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02656862 0,06542593 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02656862 0,06535596 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02656862 0,06528613 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02656862 0,06521646 ! sulfate transport GO:0008272 12 10 0,000 0,02656862 0,06514693 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02656862 0,06507755 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02656862 0,06500832 ! androgen metabolic process GO:0008209 13 10 0,000 0,02656862 0,06493923 ! phospholipid efflux GO:0033700 16 10 0,000 0,02656862 0,0648703 ! hippocampus development GO:0021766 19 10 0,000 0,02656862 0,06480151 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02656862 0,06473286 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02656862 0,06466436 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02656862 0,064596 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02656862 0,06452779 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02656862 0,06445973 ! pathogenesis GO:0009405 13 10 0,000 0,02656862 0,0643918 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02656862 0,06432402 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02656862 0,06425638 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02656862 0,06418889 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02656862 0,06412153 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02656862 0,06405432 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02656862 0,06398725 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02656862 0,06392031 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02656862 0,06385352 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02656862 0,06378687 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02656862 0,06372035 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02656862 0,06365398 ! response to X-ray GO:0010165 16 10 0,000 0,02656862 0,06358774 ! B cell proliferation GO:0042100 14 10 0,000 0,02656862 0,06352164 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02656862 0,06345568 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02656862 0,06338985 ! forebrain cell migration GO:0021885 17 10 0,000 0,02656862 0,06332417 ! lipid digestion GO:0044241 15 10 0,000 0,02656862 0,06325861 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02656862 0,0631932 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02656862 0,06312791 ! UV protection GO:0009650 14 10 0,000 0,02656862 0,06306277 ! entry into host cell GO:0030260 20 10 0,000 0,02656862 0,06299775 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02656862 0,06293287 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02656862 0,06286813 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02656862 0,06280351 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02656862 0,06273903 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02656862 0,06267469 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02656862 0,06261047 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02656862 0,06254639 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02656862 0,06248243 ! regulation of organ growth GO:0046620 11 10 0,000 0,02656862 0,06241861 ! response to dsRNA GO:0043331 18 10 0,000 0,02656862 0,06235492 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02656862 0,06229136 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02656862 0,06222792 ! embryonic axis specification GO:0000578 12 10 0,000 0,02656862 0,06216462 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02656862 0,06210144 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02656862 0,0620384 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02656862 0,06197548 ! cranial nerve development GO:0021545 12 10 0,000 0,02656862 0,06191268 ! fucose catabolic process GO:0019317 16 10 0,000 0,02656862 0,06185002 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02656862 0,06178748 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02656862 0,06172507 ! protein sumoylation GO:0016925 12 10 0,000 0,02656862 0,06166278 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02656862 0,06160062 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02656862 0,06153859 ! zymogen activation GO:0031638 14 10 0,000 0,02656862 0,06147668 ! salivary gland development GO:0007431 22 10 0,000 0,02656862 0,06141489 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02656862 0,06135323 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02656862 0,06129169 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02656862 0,06123028 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02656862 0,06116899 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02656862 0,06110782 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02656862 0,06104677 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02656862 0,06098585 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02656862 0,06092504 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02656862 0,06086436 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,02656862 0,0608038 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02656862 0,06074336 ! detection of bacterium GO:0016045 10 10 0,000 0,02656862 0,06068304 ! embryonic gut development GO:0048566 11 10 0,000 0,02656862 0,06062284 ! activation of innate immune response GO:0002218 10 10 0,000 0,02656862 0,06056276 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02656862 0,06050279 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02656862 0,06044295 ! developmental induction GO:0031128 13 10 0,000 0,02656862 0,06038322 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02656862 0,06032361 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02656862 0,06026412 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02656862 0,06020475 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,02656862 0,06014549 ! regulation of binding GO:0051098 151 95 1,000 0,02695892 0,06096905 ! rRNA transcription GO:0009303 17 11 0,000 0,02918717 0,0659435 ! respiratory burst GO:0045730 14 11 0,000 0,02918717 0,06587878 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,02918717 0,0658142 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,02918717 0,06574974 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,02918717 0,0656854 ! virus-host interaction GO:0019048 17 11 0,000 0,02918717 0,06562119 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,02918717 0,06555711 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,02918717 0,06549315 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,02918717 0,06542932 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,02918717 0,06536561 ! RNA polyadenylation GO:0043631 19 11 0,000 0,02918717 0,06530202 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,02918717 0,06523856 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,02918717 0,06517522 ! mating GO:0007618 14 11 0,000 0,02918717 0,06511201 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,02918717 0,06504892 ! T cell proliferation GO:0042098 20 11 0,000 0,02918717 0,06498594 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,02918717 0,0649231 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,02918717 0,06486037 ! bone resorption GO:0045453 16 11 0,000 0,02918717 0,06479776 ! regulated secretory pathway GO:0045055 14 11 0,000 0,02918717 0,06473528 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,02918717 0,06467291 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,02918717 0,06461066 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,02918717 0,06454854 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,02918717 0,06448653 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,02918717 0,06442465 ! syncytium formation GO:0006949 15 11 0,000 0,02918717 0,06436288 ! plasma membrane organization GO:0007009 18 11 0,000 0,02918717 0,06430123 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,02918717 0,06423969 ! focal adhesion formation GO:0048041 24 11 0,000 0,02918717 0,06417828 ! mitotic spindle organization GO:0007052 15 11 0,000 0,02918717 0,06411698 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,02918717 0,0640558 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,02918717 0,06399474 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,02918717 0,06393379 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,02918717 0,06387296 ! adult heart development GO:0007512 11 11 0,000 0,02918717 0,06381224 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,02918717 0,06375164 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,02918717 0,06369116 ! temperature homeostasis GO:0001659 16 11 0,000 0,02918717 0,06363079 ! L-glutamate transport GO:0015813 16 11 0,000 0,02918717 0,06357053 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,02918717 0,06351039 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,02918717 0,06345036 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,02918717 0,06339044 ! stem cell development GO:0048864 29 11 0,000 0,02918717 0,06333064 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,02918717 0,06327095 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,02918717 0,06321138 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,02918717 0,06315191 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,02918717 0,06309256 ! vasoconstriction GO:0042310 15 11 0,000 0,02918717 0,06303332 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,02918717 0,06297418 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,02918717 0,06291516 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,02918717 0,06285626 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,02918717 0,06279746 ! ribosome assembly GO:0042255 13 11 0,000 0,02918717 0,06273877 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,02918717 0,06268019 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,02918717 0,06262172 ! chromatin silencing GO:0006342 19 11 0,000 0,02918717 0,06256336 ! nucleosome positioning GO:0016584 13 11 0,000 0,02918717 0,0625051 ! regulation of isotype switching GO:0045191 19 11 0,000 0,02918717 0,06244696 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,02918717 0,06238892 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,02918717 0,06233099 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,02918717 0,06227317 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,02918717 0,06221546 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,02918717 0,06215785 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,02918717 0,06210035 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,02918717 0,06204296 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,02918717 0,06198567 ! male genitalia development GO:0030539 13 11 0,000 0,02918717 0,06192849 ! cholesterol efflux GO:0033344 19 11 0,000 0,02918717 0,06187141 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,02918717 0,06181444 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,02918717 0,06175757 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,02918717 0,06170081 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,02918717 0,06164415 GO:0010829|negative regulation of glucose transport, ! regulation of organic acid transport GO:0032890 17 11 0,000 0,02918717 0,0615876 ! defense response to fungus GO:0050832 12 11 0,000 0,02918717 0,06153115 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,02918717 0,0614748 ! lysogeny GO:0030069 18 11 0,000 0,02918717 0,06141856 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,02918717 0,06136241 ! acrosome reaction GO:0007340 13 11 0,000 0,02918717 0,06130638 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,02918717 0,06125044 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,02963597 0,06213558 ! lactation GO:0007595 20 12 0,000 0,03179882 0,06660955 ! reproductive cellular process GO:0048610 14 12 0,000 0,03179882 0,06654894 ! tRNA modification GO:0006400 14 12 0,000 0,03179882 0,06648844 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,03179882 0,06642805 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,03179882 0,06636777 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,03179882 0,0663076 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,03179882 0,06624754 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,03179882 0,06618759 ! non-recombinational repair GO:0000726 19 12 0,000 0,03179882 0,06612774 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,03179882 0,06606801 ! peroxisomal transport GO:0043574 21 12 0,000 0,03179882 0,06600838 ! cartilage condensation GO:0001502 18 12 0,000 0,03179882 0,06594886 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,03179882 0,06588945 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,03179882 0,06583014 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,03179882 0,06577094 ! heart looping GO:0001947 15 12 0,000 0,03179882 0,06571185 ! palate development GO:0060021 15 12 0,000 0,03179882 0,06565286 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,03179882 0,06559398 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,03179882 0,0655352 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,03179882 0,06547653 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,03179882 0,06541796 ! arginine metabolic process GO:0006525 13 12 0,000 0,03179882 0,0653595 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,03179882 0,06530115 ! methionine metabolic process GO:0006555 13 12 0,000 0,03179882 0,06524289 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,03179882 0,06518475 ! Golgi organization GO:0007030 18 12 0,000 0,03179882 0,0651267 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,03179882 0,06506876 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,03179882 0,06501092 ! monoamine transport GO:0015844 13 12 0,000 0,03179882 0,06495318 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03179882 0,06489555 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,03179882 0,06483802 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,03179882 0,06478059 ! L-amino acid transport GO:0015807 20 12 0,000 0,03179882 0,06472326 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,03179882 0,06466603 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,03179882 0,06460891 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,03179882 0,06455188 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,03179882 0,06449496 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,03179882 0,06443814 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,03179882 0,06438141 ! cerebellum development GO:0021549 13 12 0,000 0,03179882 0,06432479 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,03179882 0,06426826 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,03179882 0,06421184 ! histone acetylation GO:0016573 23 12 0,000 0,03179882 0,06415551 ! histone methylation GO:0016571 15 12 0,000 0,03179882 0,06409929 ! autonomic nervous system development GO:0048483 23 12 0,000 0,03179882 0,06404316 ! gland morphogenesis GO:0022612 23 12 0,000 0,03179882 0,06398713 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,03179882 0,06393119 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,03179882 0,06387536 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,03179882 0,06381962 ! response to gamma radiation GO:0010332 20 12 0,000 0,03179882 0,06376398 ! regulation of epidermis development GO:0045682 17 12 0,000 0,03179882 0,06370844 ! intestinal absorption GO:0050892 19 12 0,000 0,03179882 0,06365299 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,03179882 0,06359764 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,03179882 0,06354238 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,03179882 0,06348723 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,03179882 0,06343216 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,03179882 0,0633772 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,03179882 0,06332232 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,03179882 0,06326755 ! microspike assembly GO:0030035 23 12 0,000 0,03179882 0,06321286 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,03179882 0,06315828 ! response to cold GO:0009409 14 12 0,000 0,03179882 0,06310378 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,0344036 0,06821403 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,0344036 0,06815527 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,0344036 0,06809662 ! cGMP metabolic process GO:0046068 16 13 0,000 0,0344036 0,06803807 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,0344036 0,06797961 ! water transport GO:0006833 17 13 0,000 0,0344036 0,06792126 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,0344036 0,06786301 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,0344036 0,06780486 ! lipid localization GO:0010876 24 13 0,000 0,0344036 0,06774681 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,0344036 0,06768886 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,0344036 0,067631 ! organelle fusion GO:0048284 28 13 0,000 0,0344036 0,06757325 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,0344036 0,06751559 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,0344036 0,06745803 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,0344036 0,06740057 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,0344036 0,06734321 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,0344036 0,06728595 ! response to hexose stimulus GO:0009746 19 13 0,000 0,0344036 0,06722878 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,0344036 0,06717171 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,0344036 0,06711473 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,0344036 0,06705786 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,0344036 0,06700108 ! NAD metabolic process GO:0019674 21 13 0,000 0,0344036 0,06694439 ! exocrine system development GO:0035272 27 13 0,000 0,0344036 0,0668878 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,0344036 0,06683131 ! bone mineralization GO:0030282 15 13 0,000 0,0344036 0,06677491 ! regulation of exocytosis GO:0017157 17 13 0,000 0,0344036 0,06671861 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,0344036 0,0666624 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,0344036 0,06660629 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,0344036 0,06655027 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,0344036 0,06649435 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,0344036 0,06643852 ! genitalia development GO:0048806 15 13 0,000 0,0344036 0,06638278 ! regulation of cellular pH GO:0030641 20 13 0,000 0,0344036 0,06632713 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,0344036 0,06627158 ! cellular pigmentation GO:0033059 24 13 0,000 0,0344036 0,06621613 ! tissue regeneration GO:0042246 21 13 0,000 0,0344036 0,06616076 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,0344036 0,06610549 ! cofactor transport GO:0051181 19 13 0,000 0,0344036 0,06605031 ! NADP metabolic process GO:0006739 18 13 0,000 0,0344036 0,06599522 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,0344036 0,06594023 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,0344036 0,06588532 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,0344036 0,06583051 ! gas transport GO:0015669 18 13 0,000 0,0344036 0,06577579 ! regulation of RNA stability GO:0043487 28 13 0,000 0,0344036 0,06572116 ! heme biosynthetic process GO:0006783 20 13 0,000 0,0344036 0,06566662 ! regulation of axon extension GO:0030516 23 13 0,000 0,0344036 0,06561217 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,0344036 0,06555781 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,0344036 0,06550354 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,0344036 0,06544936 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,0344036 0,06539527 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,0344036 0,06534126 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,03700151 0,0702174 ! superoxide anion generation GO:0042554 18 14 0,000 0,03700151 0,07015951 ! neuron maturation GO:0042551 21 14 0,000 0,03700151 0,07010172 ! regulation of S phase GO:0033261 18 14 0,000 0,03700151 0,07004402 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,03700151 0,06998642 ! myotube differentiation GO:0014902 21 14 0,000 0,03700151 0,06992891 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,03700151 0,0698715 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,03700151 0,06981418 ! inositol metabolic process GO:0006020 20 14 0,000 0,03700151 0,06975695 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,03700151 0,06969982 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,03700151 0,06964279 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,03700151 0,06958584 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,03700151 0,06952899 ! gene silencing by RNA GO:0031047 20 14 0,000 0,03700151 0,06947223 ! response to cAMP GO:0051591 19 14 0,000 0,03700151 0,06941557 ! limbic system development GO:0021761 25 14 0,000 0,03700151 0,06935899 ! startle response GO:0001964 21 14 0,000 0,03700151 0,06930251 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,03700151 0,06924612 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,03700151 0,06918982 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,03700151 0,06913362 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,03700151 0,0690775 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,03700151 0,06902148 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,03700151 0,06896555 ! glycine metabolic process GO:0006544 22 14 0,000 0,03700151 0,0689097 ! pituitary gland development GO:0021983 23 14 0,000 0,03700151 0,06885395 ! cellular response to starvation GO:0009267 21 14 0,000 0,03700151 0,06879829 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,03700151 0,06874272 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,03700151 0,06868723 ! regulation of heart rate GO:0002027 23 14 0,000 0,03700151 0,06863184 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,03700151 0,06857654 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,03700151 0,06852132 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,03700151 0,0684662 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,03700151 0,06841116 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,03700151 0,06835621 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,03700151 0,06830135 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,03700151 0,06824658 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,03700151 0,06819189 ! axon cargo transport GO:0008088 27 14 0,000 0,03700151 0,0681373 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,03700151 0,06808279 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,03700151 0,06802836 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,03700151 0,06797403 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,03700151 0,06791978 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03700151 0,06786562 ! mRNA splice site selection GO:0006376 26 14 0,000 0,03700151 0,06781154 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,03700151 0,06775755 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,03700151 0,06770365 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,03700151 0,06764983 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,03700151 0,06759609 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,03700151 0,06754245 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,03700151 0,06748888 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,03700151 0,06743541 ! muscle maintenance GO:0046716 19 14 0,000 0,03700151 0,06738201 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,03700151 0,06732871 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,03700151 0,06727548 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,03700151 0,06722234 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,03700151 0,06716928 ! cell killing GO:0001906 20 14 0,000 0,03700151 0,06711631 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,03700151 0,06706342 ! cilium assembly GO:0042384 20 14 0,000 0,03700151 0,06701062 ! peptide hormone secretion GO:0030072 23 14 0,000 0,03700151 0,06695789 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,03959259 0,07159038 ! positive regulation of cell size GO:0045793 20 15 0,000 0,03959259 0,07153414 ! metencephalon development GO:0022037 19 15 0,000 0,03959259 0,07147799 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,03959259 0,07142193 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,03959259 0,07136596 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,03959259 0,07131007 ! skin development GO:0043588 25 15 0,000 0,03959259 0,07125427 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,03959259 0,07119856 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,03959259 0,07114294 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,03959259 0,0710874 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,03959259 0,07103195 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,03959259 0,07097659 ! bile acid metabolic process GO:0008206 22 15 0,000 0,03959259 0,07092131 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,03959259 0,07086612 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,03959259 0,07081101 ! adult walking behavior GO:0007628 25 15 0,000 0,03959259 0,07075599 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,03959259 0,07070106 ! myoblast differentiation GO:0045445 27 15 0,000 0,03959259 0,07064621 ! centrosome cycle GO:0007098 16 15 0,000 0,03959259 0,07059144 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,03959259 0,07053676 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,03959259 0,07048217 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,03959259 0,07042766 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,03959259 0,07037323 ! cerebral cortex development GO:0021987 29 15 0,000 0,03959259 0,07031889 ! response to osmotic stress GO:0006970 22 15 0,000 0,03959259 0,07026463 ! vesicle coating GO:0006901 25 15 0,000 0,03959259 0,07021045 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,03959259 0,07015636 ! DNA integration GO:0015074 22 15 0,000 0,03959259 0,07010236 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,03959259 0,07004843 ! peptide secretion GO:0002790 27 15 0,000 0,03959259 0,06999459 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,03959259 0,06994083 ! regulation of vasodilation GO:0042312 24 15 0,000 0,03959259 0,06988715 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,03959259 0,06983356 ! neuron recognition GO:0008038 22 15 0,000 0,03959259 0,06978005 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,03959259 0,06972662 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,03959259 0,06967327 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,03959259 0,06962 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,03959259 0,06956681 ! biomineral formation GO:0031214 18 15 0,000 0,03959259 0,06951371 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,03959259 0,06946069 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,03959259 0,06940774 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,03959259 0,06935488 ! dopamine metabolic process GO:0042417 30 15 0,000 0,03959259 0,0693021 ! organic cation transport GO:0015695 19 15 0,000 0,03959259 0,0692494 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,03959259 0,06919678 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,03959259 0,06914424 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,03959259 0,06909178 ! defense response to virus GO:0051607 27 15 0,000 0,03959259 0,06903939 ! peptide hormone processing GO:0016486 19 15 0,000 0,03959259 0,06898709 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,03959259 0,06893487 ! protein secretion GO:0009306 27 16 0,000 0,04217684 0,07337878 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,04217684 0,07332331 ! hormone secretion GO:0046879 25 16 0,000 0,04217684 0,07326793 ! bone remodeling GO:0046849 24 16 0,000 0,04217684 0,07321264 ! endothelial cell migration GO:0043542 22 16 0,000 0,04217684 0,07315742 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,04217684 0,07310229 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,04217684 0,07304725 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04217684 0,07299228 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,04217684 0,0729374 ! glial cell development GO:0021782 24 16 0,000 0,04217684 0,0728826 ! patterning of blood vessels GO:0001569 24 16 0,000 0,04217684 0,07282788 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,04217684 0,07277325 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,04217684 0,0727187 ! protein polyubiquitination GO:0000209 26 16 0,000 0,04217684 0,07266423 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,04217684 0,07260984 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,04217684 0,07255553 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,04217684 0,0725013 ! fructose metabolic process GO:0006000 20 16 0,000 0,04217684 0,07244716 ! regulation of protein binding GO:0043393 27 16 0,000 0,04217684 0,07239309 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,04217684 0,07233911 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,04217684 0,0722852 ! protein export from nucleus GO:0006611 24 16 0,000 0,04217684 0,07223138 ! negative regulation of immune response GO:0050777 28 16 0,000 0,04217684 0,07217764 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,04217684 0,07212397 ! DNA replication initiation GO:0006270 25 16 0,000 0,04217684 0,07207039 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,04217684 0,07201688 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,04217684 0,07196346 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,04217684 0,07191011 ! diencephalon development GO:0021536 25 16 0,000 0,04217684 0,07185685 ! oogenesis GO:0048477 23 16 0,000 0,04217684 0,07180366 ! neural crest cell migration GO:0001755 24 16 0,000 0,04217684 0,07175055 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,04217684 0,07169752 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,04217684 0,07164457 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,04217684 0,07159169 ! steroid catabolic process GO:0006706 22 16 0,000 0,04217684 0,0715389 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,04217684 0,07148618 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,04217684 0,07143354 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,04217684 0,07138097 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,04217684 0,07132849 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,04217684 0,07127608 ! sperm-egg recognition GO:0035036 16 16 0,000 0,04217684 0,07122375 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,04217684 0,07117149 ! nerve development GO:0021675 18 16 0,000 0,04217684 0,07111931 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,04217684 0,07106721 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,04217684 0,07101518 ! negative regulation of translation GO:0017148 22 16 0,000 0,04217684 0,07096323 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,04475429 0,07524479 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,04475429 0,07518982 ! negative regulation of defense response GO:0031348 19 17 0,000 0,04475429 0,07513494 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,04475429 0,07508014 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,04475429 0,07502542 ! glycerol metabolic process GO:0006071 20 17 0,000 0,04475429 0,07497077 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,04475429 0,07491621 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,04475429 0,07486172 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,04475429 0,07480732 ! signal complex assembly GO:0007172 29 17 0,000 0,04475429 0,07475299 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,04475429 0,07469874 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,04475429 0,07464458 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,04475429 0,07459049 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,04475429 0,07453647 ! memory GO:0007613 25 17 0,000 0,04475429 0,07448254 ! keratinization GO:0031424 17 17 0,000 0,04475429 0,07442868 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,04475429 0,07437491 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,04475429 0,07432121 ! retinoid metabolic process GO:0001523 22 17 0,000 0,04475429 0,07426758 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,04475429 0,07421404 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,04475429 0,07416057 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,04475429 0,07410718 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,04475429 0,07405386 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,04475429 0,07400063 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,04475429 0,07394746 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,04475429 0,07389438 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,04475429 0,07384137 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,04475429 0,07378844 ! membrane budding GO:0006900 29 17 0,000 0,04475429 0,07373558 ! heme metabolic process GO:0042168 27 17 0,000 0,04475429 0,0736828 ! actin filament bundle formation GO:0051017 26 17 0,000 0,04475429 0,07363009 ! neuromuscular junction development GO:0007528 23 17 0,000 0,04475429 0,07357746 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,04475429 0,07352491 ! body fluid secretion GO:0007589 27 17 0,000 0,04475429 0,07347243 ! stem cell differentiation GO:0048863 36 17 0,000 0,04475429 0,07342002 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,04475429 0,07336769 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,04475429 0,07331543 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,04475429 0,07326325 ! sensory perception of pain GO:0019233 23 17 0,000 0,04475429 0,07321115 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,04475429 0,07315911 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,04475429 0,07310715 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,04475429 0,07305527 ! synaptogenesis GO:0007416 24 17 0,000 0,04475429 0,07300345 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,04475429 0,07295172 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,04475429 0,07290005 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,04475429 0,07284846 ! cell-cell junction organization GO:0045216 25 17 0,000 0,04475429 0,07279694 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,04475429 0,07274549 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,04475429 0,07269412 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,04475429 0,07264282 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,04475429 0,07259159 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,04475429 0,07254043 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,04475429 0,07248935 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,04732495 0,07659914 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,04732495 0,07654528 ! positive regulation of translation GO:0045727 28 18 0,000 0,04732495 0,07649149 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,04732495 0,07643777 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,04732495 0,07638413 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,04732495 0,07633056 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,04732495 0,07627707 ! cAMP metabolic process GO:0046058 33 18 0,000 0,04732495 0,07622366 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,04732495 0,07617032 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,04732495 0,07611705 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,04732495 0,07606386 ! axis specification GO:0009798 26 18 0,000 0,04732495 0,07601074 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,04732495 0,0759577 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,04732495 0,07590473 ! pancreas development GO:0031016 26 18 0,000 0,04732495 0,07585184 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,04732495 0,07579901 ! glutamine metabolic process GO:0006541 23 18 0,000 0,04732495 0,07574627 ! response to retinoic acid GO:0032526 25 18 0,000 0,04732495 0,07569359 ! pigmentation during development GO:0048066 31 18 0,000 0,04732495 0,07564099 ! central nervous system neuron development GO:0021954 30 18 0,000 0,04732495 0,07558846 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,04732495 0,07553601 ! fucose metabolic process GO:0006004 26 18 0,000 0,04732495 0,07548362 ! response to fungus GO:0009620 19 18 0,000 0,04732495 0,07543131 ! peptide cross-linking GO:0018149 31 18 0,000 0,04732495 0,07537907 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,04732495 0,07532691 ! heart process GO:0003015 27 18 0,000 0,04732495 0,07527482 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,04732495 0,07522279 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,04732495 0,07517085 ! somitogenesis GO:0001756 24 18 0,000 0,04732495 0,07511897 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,04732495 0,07506716 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,04732495 0,07501543 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,04732495 0,07496376 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,04732495 0,07491217 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,04732495 0,07486065 ! vitamin transport GO:0051180 24 18 0,000 0,04732495 0,0748092 ! hormone transport GO:0009914 27 18 0,000 0,04732495 0,07475782 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,04732495 0,07470651 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,04732495 0,07465527 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,04732495 0,0746041 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,04732495 0,074553 ! cell-cell recognition GO:0009988 20 18 0,000 0,04732495 0,07450197 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,04732495 0,07445102 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,04732495 0,07440013 ! regulation of glucose import GO:0046324 21 18 0,000 0,04732495 0,07434931 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,04732495 0,07429856 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,04732495 0,07424787 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,04732495 0,07419726 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,04988884 0,07816371 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,04988884 0,0781105 ! positive regulation of ossification GO:0045778 30 19 0,000 0,04988884 0,07805736 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,04988884 0,0780043 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,04988884 0,07795131 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,04988884 0,07789839 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,04988884 0,07784554 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,04988884 0,07779276 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,04988884 0,07774006 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,04988884 0,07768742 ! regeneration GO:0031099 32 19 0,000 0,04988884 0,07763486 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,04988884 0,07758237 ! response to alkaloid GO:0043279 32 19 0,000 0,04988884 0,07752995 ! sensory perception of taste GO:0050909 23 19 0,000 0,04988884 0,0774776 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,04988884 0,07742532 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,04988884 0,07737311 ! smooth muscle contraction GO:0006939 36 19 0,000 0,04988884 0,07732097 ! peroxisome organization GO:0007031 29 19 0,000 0,04988884 0,07726891 ! digestive system process GO:0022600 30 19 0,000 0,04988884 0,07721691 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,04988884 0,07716498 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,04988884 0,07711312 ! response to vitamin A GO:0033189 26 19 0,000 0,04988884 0,07706133 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,04988884 0,07700961 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,04988884 0,07695796 ! response to starvation GO:0042594 30 19 0,000 0,04988884 0,07690638 ! sex determination GO:0007530 29 19 0,000 0,04988884 0,07685487 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,04988884 0,07680343 ! plasma membrane fusion GO:0045026 23 19 0,000 0,04988884 0,07675206 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,04988884 0,07670075 ! cytolysis GO:0019835 20 19 0,000 0,04988884 0,07664952 ! renal system process GO:0003014 35 19 0,000 0,04988884 0,07659835 ! vasodilation GO:0042311 33 19 0,000 0,04988884 0,07654725 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,04988884 0,07649622 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,04988884 0,07644525 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,04988884 0,07639436 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,04988884 0,07634353 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,04988884 0,07629277 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,04988884 0,07624208 ! sarcomere organization GO:0045214 23 19 0,000 0,04988884 0,07619145 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,04988884 0,07614089 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,04988884 0,0760904 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,04988884 0,07603998 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,04988884 0,07598962 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,04988884 0,07593933 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,04988884 0,0758891 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,04988884 0,07583895 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,04988884 0,07578885 ! protein stabilization GO:0050821 26 19 0,000 0,04988884 0,07573883 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,05244597 0,07956842 ! iron ion transport GO:0006826 37 20 0,000 0,05244597 0,07951597 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,05244597 0,07946359 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,05244597 0,07941128 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,05244597 0,07935903 ! response to vitamin GO:0033273 29 20 0,000 0,05244597 0,07930686 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,05244597 0,07925475 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,05244597 0,07920271 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,05244597 0,07915074 ! spinal cord development GO:0021510 31 20 0,000 0,05244597 0,07909884 ! response to ethanol GO:0045471 37 20 0,000 0,05244597 0,07904701 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,05244597 0,07899524 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,05244597 0,07894354 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,05244597 0,07889191 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,05244597 0,07884035 ! chromosome condensation GO:0030261 31 20 0,000 0,05244597 0,07878885 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,05244597 0,07873742 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,05244597 0,07868606 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,05244597 0,07863477 ! pallium development GO:0021543 38 20 0,000 0,05244597 0,07858354 ! DNA modification GO:0006304 28 20 0,000 0,05244597 0,07853238 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,05244597 0,07848128 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,05244597 0,07843026 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,05244597 0,07837929 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,05244597 0,0783284 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,05244597 0,07827757 ! collagen catabolic process GO:0030574 25 20 0,000 0,05244597 0,0782268 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,05244597 0,07817611 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,05244597 0,07812547 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,05244597 0,07807491 ! alditol metabolic process GO:0019400 24 20 0,000 0,05244597 0,07802441 ! actin filament-based movement GO:0030048 34 20 0,000 0,05244597 0,07797397 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,05499637 0,08171295 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,05499637 0,0816602 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,05499637 0,08160751 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,05499637 0,0815549 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,05499637 0,08150235 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,05499637 0,08144987 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,05499637 0,08139746 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,05499637 0,08134511 GO:0034105|positive regulation of tissue remodeling, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,05499637 0,08129283 ! protein amino acid acylation GO:0043543 37 21 0,000 0,05499637 0,08124062 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,05499637 0,08118848 ! vesicle docking GO:0048278 27 21 0,000 0,05499637 0,0811364 ! phototransduction GO:0007602 25 21 0,000 0,05499637 0,08108439 ! dendrite development GO:0016358 35 21 0,000 0,05499637 0,08103244 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,05499637 0,08098057 ! ovarian follicle development GO:0001541 30 21 0,000 0,05499637 0,08092876 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,05499637 0,08087701 ! autophagy GO:0006914 28 21 0,000 0,05499637 0,08082533 ! cell aging GO:0007569 32 21 0,000 0,05499637 0,08077372 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,05499637 0,08072217 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,05499637 0,08067069 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,05499637 0,08061928 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,05499637 0,08056793 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,05499637 0,08051664 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,05499637 0,08046542 GO:0060415|muscle tissue morphogenesis, ! leukotriene metabolic process GO:0006691 28 21 0,000 0,05499637 0,08041427 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,05499637 0,08036318 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,05499637 0,08031216 ! fatty acid transport GO:0015908 30 21 0,000 0,05499637 0,0802612 ! immunoglobulin production GO:0002377 33 21 0,000 0,05499637 0,0802103 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,05499637 0,08015947 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,05499637 0,08010871 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,05499637 0,080058 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,05499637 0,08000737 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,05499637 0,07995679 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,05499637 0,07990628 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,05499637 0,07985584 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,05499637 0,07980546 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,05499637 0,07975514 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,05499637 0,07970488 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,05499637 0,07965469 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,05499637 0,07960456 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,05499637 0,07955449 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,05499637 0,07950449 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,05754005 0,08312946 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,05754005 0,08307728 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,05754005 0,08302516 ! viral genome replication GO:0019079 29 22 0,000 0,05754005 0,08297311 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,05754005 0,08292112 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,05754005 0,0828692 ! leukocyte adhesion GO:0007159 38 22 0,000 0,05754005 0,08281734 ! molting cycle process GO:0022404 40 22 0,000 0,05754005 0,08276555 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,05754005 0,08271382 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,05754005 0,08266215 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,05754005 0,08261055 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,05754005 0,08255902 ! vasculogenesis GO:0001570 33 22 0,000 0,05754005 0,08250755 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,05754005 0,08245614 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,05754005 0,0824048 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,05754005 0,08235352 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,05754005 0,08230231 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,05754005 0,08225115 ! lysosome organization GO:0007040 37 22 0,000 0,05754005 0,08220007 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,05754005 0,08214904 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,05754005 0,08209808 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,05754005 0,08204718 ! regulation of behavior GO:0050795 38 22 0,000 0,05754005 0,08199635 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,05754005 0,08194558 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,05754005 0,08189487 ! membrane depolarization GO:0051899 35 22 0,000 0,05754005 0,08184422 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,05754005 0,08179364 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,05754005 0,08174312 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,05754005 0,08169266 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,05754005 0,08164226 ! blastocyst development GO:0001824 37 22 0,000 0,05754005 0,08159193 ! neural tube closure GO:0001843 33 22 0,000 0,05754005 0,08154166 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,05754005 0,08149145 ! protein tetramerization GO:0051262 39 22 0,000 0,05754005 0,0814413 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,06007702 0,0849798 ! neuron fate commitment GO:0048663 32 23 0,000 0,06007702 0,08492757 ! embryonic pattern specification GO:0009880 31 23 0,000 0,06007702 0,0848754 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,06007702 0,0848233 ! myelination GO:0042552 35 23 0,000 0,06007702 0,08477126 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,06007702 0,08471929 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,06007702 0,08466737 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,06007702 0,08461553 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,06007702 0,08456374 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,06007702 0,08451202 ! vesicle targeting GO:0006903 32 23 0,000 0,06007702 0,08446036 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,06007702 0,08440877 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,06007702 0,08435724 ! osteoblast differentiation GO:0001649 40 23 0,000 0,06007702 0,08430577 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,06007702 0,08425436 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,06007702 0,08420302 ! interaction with host GO:0051701 37 23 0,000 0,06007702 0,08415174 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,06007702 0,08410052 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,06007702 0,08404936 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,06007702 0,08399827 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,06007702 0,08394724 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,06007702 0,08389627 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,06007702 0,08384536 ! cell fate determination GO:0001709 45 23 0,000 0,06007702 0,08379451 ! pentose metabolic process GO:0019321 31 23 0,000 0,06007702 0,08374373 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,06007702 0,08369301 ! spermatid development GO:0007286 33 23 0,000 0,06007702 0,08364234 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,06007702 0,08359174 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,06007702 0,08354121 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,06007702 0,08349073 ! telomere organization GO:0032200 32 23 0,000 0,06007702 0,08344031 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,06007702 0,08338995 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,06007702 0,08333966 ! regulation of amine transport GO:0051952 38 23 0,000 0,06007702 0,08328942 ! liver development GO:0001889 40 23 0,000 0,06007702 0,08323925 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,06260732 0,08669285 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,06260732 0,08664069 ! initiation of viral infection GO:0019059 42 24 0,000 0,06260732 0,08658859 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,06260732 0,08653655 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,06260732 0,08648458 ! superoxide metabolic process GO:0006801 32 24 0,000 0,06260732 0,08643267 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,06260732 0,08638082 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,06260732 0,08632903 ! fat cell differentiation GO:0045444 37 24 0,000 0,06260732 0,08627731 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,06260732 0,08622564 ! sperm motility GO:0030317 27 24 0,000 0,06260732 0,08617404 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,06260732 0,0861225 ! vacuole organization GO:0007033 39 24 0,000 0,06260732 0,08607103 ! receptor metabolic process GO:0043112 37 24 0,000 0,06260732 0,08601961 ! neural crest cell development GO:0014032 39 24 0,000 0,06260732 0,08596825 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,06260732 0,08591696 ! primary neural tube formation GO:0014020 35 24 0,000 0,06260732 0,08586573 ! negative regulation of cell development GO:0010721 56 24 0,000 0,06260732 0,08581456 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,06260732 0,08576345 ! base-excision repair GO:0006284 31 24 0,000 0,06260732 0,0857124 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,06260732 0,08566141 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,06260732 0,08561048 ! glutathione metabolic process GO:0006749 29 24 0,000 0,06260732 0,08555961 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,06260732 0,0855088 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,06260732 0,08545806 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,06260732 0,08540737 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,06513094 0,08879737 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,06513094 0,08874477 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,06513094 0,08869222 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,06513094 0,08863974 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,06513094 0,08858732 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,06513094 0,08853497 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,06513094 0,08848267 ! peptide transport GO:0015833 43 25 0,000 0,06513094 0,08843044 ! male gonad development GO:0008584 33 25 0,000 0,06513094 0,08837827 ! iron ion homeostasis GO:0055072 39 25 0,000 0,06513094 0,08832616 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,06513094 0,08827411 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,06513094 0,08822212 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,06513094 0,0881702 ! phospholipid transport GO:0015914 35 25 0,000 0,06513094 0,08811833 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,06513094 0,08806653 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,06513094 0,08801479 ! detection of light stimulus GO:0009583 30 25 0,000 0,06513094 0,0879631 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,06513094 0,08791148 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,06513094 0,08785992 ! leukocyte proliferation GO:0070661 39 25 0,000 0,06513094 0,08780842 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,06764792 0,09114834 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,06764792 0,09109497 ! translational initiation GO:0006413 43 26 0,000 0,06764792 0,09104167 ! regulation of pH GO:0006885 36 26 0,000 0,06764792 0,09098843 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,06764792 0,09093525 ! circadian rhythm GO:0007623 42 26 0,000 0,06764792 0,09088213 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,06764792 0,09082908 ! post-embryonic development GO:0009791 42 26 0,000 0,06764792 0,09077609 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,06764792 0,09072315 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,06764792 0,09067029 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,06764792 0,09061748 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,06764792 0,09056473 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,06764792 0,09051205 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,06764792 0,09045942 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,06764792 0,09040686 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,06764792 0,09035436 ! regulation of coagulation GO:0050818 39 26 0,000 0,06764792 0,09030192 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,07015826 0,09359861 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,07015826 0,09354435 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,07015826 0,09349015 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,07015826 0,09343602 ! membrane docking GO:0022406 39 27 0,000 0,07015826 0,09338194 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,07015826 0,09332793 ! catechol metabolic process GO:0009712 43 27 0,000 0,07015826 0,09327399 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,07015826 0,0932201 ! acute-phase response GO:0006953 42 27 0,000 0,07015826 0,09316628 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,07015826 0,09311252 ! myofibril assembly GO:0030239 36 27 0,000 0,07015826 0,09305882 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,07015826 0,09300519 ! response to ionizing radiation GO:0010212 47 27 0,000 0,07015826 0,09295161 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,07015826 0,0928981 ! natural killer cell activation GO:0030101 35 27 0,000 0,07015826 0,09284465 ! lipid oxidation GO:0034440 38 27 0,000 0,07015826 0,09279126 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,07015826 0,09273793 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,07015826 0,09268466 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,07015826 0,09263146 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,07015826 0,09257831 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,07015826 0,09252523 ! gene silencing GO:0016458 41 27 0,000 0,07015826 0,09247221 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,07266199 0,0957174 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,07266199 0,09566261 ! phenol metabolic process GO:0018958 44 28 0,000 0,07266199 0,09560788 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,07266199 0,09555321 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,07266199 0,09549861 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,07266199 0,09544407 ! cell junction assembly GO:0034329 56 28 0,000 0,07266199 0,0953896 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,07266199 0,09533518 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,07266199 0,09528083 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,07266199 0,09522654 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,07266199 0,09517231 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,07266199 0,09511814 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,07266199 0,09506403 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,07266199 0,09500999 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,07266199 0,09495601 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,07266199 0,09490209 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,07266199 0,09484822 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,07266199 0,09479443 ! mesoderm formation GO:0001707 46 28 0,000 0,07266199 0,09474069 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,07266199 0,09468701 ! ensheathment of neurons GO:0007272 43 28 0,000 0,07266199 0,09463339 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,07266199 0,09457984 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,07266199 0,09452634 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,07266199 0,09447291 ! neural tube formation GO:0001841 41 28 0,000 0,07266199 0,09441953 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,07266199 0,09436622 ! placenta development GO:0001890 37 28 0,000 0,07266199 0,09431296 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,07515912 0,09749914 ! regulation of innate immune response GO:0045088 38 29 0,000 0,07515912 0,09744418 ! ovulation cycle process GO:0022602 41 29 0,000 0,07515912 0,09738928 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,07515912 0,09733444 ! protein targeting to membrane GO:0006612 53 29 0,000 0,07515912 0,09727967 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,07515912 0,09722495 ! mismatch repair GO:0006298 34 29 0,000 0,07515912 0,0971703 ! muscle cell development GO:0055001 38 29 0,000 0,07515912 0,09711571 ! formation of primary germ layer GO:0001704 48 29 0,000 0,07515912 0,09706118 ! telencephalon development GO:0021537 52 29 0,000 0,07515912 0,09700672 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,07515912 0,09695231 ! eye morphogenesis GO:0048592 51 29 0,000 0,07515912 0,09689796 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,07515912 0,09684368 ! tissue homeostasis GO:0001894 42 29 0,000 0,07515912 0,09678946 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,07764966 0,09994081 ! collagen metabolic process GO:0032963 40 30 0,000 0,07764966 0,09988491 ! organic anion transport GO:0015711 51 30 0,000 0,07764966 0,09982908 ! cholesterol transport GO:0030301 46 30 0,000 0,07764966 0,09977331 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,07764966 0,0997176 ! spliceosome assembly GO:0000245 49 30 0,000 0,07764966 0,09966196 ! spindle organization GO:0007051 37 30 0,000 0,07764966 0,09960637 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,07764966 0,09955085 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,07764966 0,09949539 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,07764966 0,09943999 ! ceramide metabolic process GO:0006672 43 30 0,000 0,07764966 0,09938466 ! ovulation cycle GO:0042698 43 30 0,000 0,07764966 0,09932938 ! hindbrain development GO:0030902 45 30 0,000 0,07764966 0,09927417 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,07764966 0,09921902 ! adult locomotory behavior GO:0008344 47 30 0,000 0,07764966 0,09916392 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,07764966 0,09910889 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,07764966 0,09905393 ! response to heat GO:0009408 41 30 0,000 0,07764966 0,09899902 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,07764966 0,09894417 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,07764966 0,09888938 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,08013365 0,10199634 ! negative regulation of secretion GO:0051048 49 31 0,000 0,08013365 0,10193993 ! mammary gland development GO:0030879 57 31 0,000 0,08013365 0,10188358 ! glial cell differentiation GO:0010001 55 31 0,000 0,08013365 0,10182729 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,08013365 0,10177106 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,08013365 0,10171489 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,08013365 0,10165879 ! odontogenesis GO:0042476 50 31 0,000 0,08013365 0,10160275 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,08013365 0,10154677 ! segmentation GO:0035282 41 31 0,000 0,08013365 0,10149085 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,08013365 0,101435 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,08013365 0,1013792 ! metanephros development GO:0001656 58 31 0,000 0,08013365 0,10132347 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,08013365 0,1012678 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,08013365 0,10121218 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,08013365 0,10115663 ! cell fate specification GO:0001708 37 31 0,000 0,08013365 0,10110115 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,08013365 0,10104572 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,08013365 0,10099035 ! RNA modification GO:0009451 40 31 0,000 0,08013365 0,10093504 ! regulation of muscle development GO:0048634 48 32 0,000 0,08261108 0,10399863 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,08261108 0,10394173 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,08261108 0,1038849 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,08261108 0,10382814 ! meiosis I GO:0007127 52 32 0,000 0,08261108 0,10377143 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,08261108 0,10371479 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,08261108 0,1036582 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,08261108 0,10360168 ! peripheral nervous system development GO:0007422 53 32 0,000 0,08261108 0,10354523 ! regulation of protein stability GO:0031647 48 32 0,000 0,08261108 0,10348883 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,08261108 0,10343249 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,08261108 0,10337622 ! cytokine production GO:0001816 44 32 0,000 0,08261108 0,10332 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,08261108 0,10326385 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,08261108 0,10320776 ! vesicle localization GO:0051648 47 32 0,000 0,08261108 0,10315173 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,08508199 0,10617936 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,08508199 0,10612178 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,08508199 0,10606426 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,08508199 0,10600681 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,08508199 0,10594941 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,08508199 0,10589208 ! sister chromatid segregation GO:0000819 46 33 0,000 0,08508199 0,10583481 ! ear morphogenesis GO:0042471 42 33 0,000 0,08508199 0,1057776 ! actomyosin structure organization GO:0031032 43 33 0,000 0,08508199 0,10572046 ! cell junction organization GO:0034330 63 33 0,000 0,08508199 0,10566337 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,08508199 0,10560635 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,08508199 0,10554939 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,08508199 0,10549249 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,08508199 0,10543565 ! female gonad development GO:0008585 49 33 0,000 0,08508199 0,10537887 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,08508199 0,10532216 ! positive regulation of cell development GO:0010720 54 33 0,000 0,08508199 0,1052655 ! lipid homeostasis GO:0055088 55 33 0,000 0,08508199 0,10520891 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,08508199 0,10515237 ! regulation of proteolysis GO:0030162 50 33 0,000 0,08508199 0,1050959 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,08508199 0,10503949 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,08508199 0,10498314 ! cytokinesis GO:0000910 52 33 0,000 0,08508199 0,10492685 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,08508199 0,10487062 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,08754638 0,10785038 ! mRNA catabolic process GO:0006402 48 34 0,000 0,08754638 0,10779265 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,08754638 0,10773497 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,08754638 0,10767736 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,08754638 0,10761981 ! feeding behavior GO:0007631 45 34 0,000 0,08754638 0,10756232 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,08754638 0,10750489 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,08754638 0,10744753 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,08754638 0,10739022 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,08754638 0,10733298 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,08754638 0,10727579 ! neuron migration GO:0001764 46 34 0,000 0,08754638 0,10721867 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,08754638 0,10716161 ! female gamete generation GO:0007292 43 34 0,000 0,08754638 0,10710461 ! polyol metabolic process GO:0019751 44 34 0,000 0,08754638 0,10704767 ! aerobic respiration GO:0009060 47 34 0,000 0,08754638 0,10699079 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,08754638 0,10693397 ! embryonic organ development GO:0048568 45 34 0,000 0,08754638 0,10687721 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,08754638 0,10682051 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,09000427 0,1097613 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,09000427 0,10970314 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,09000427 0,10964503 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,09000427 0,10958699 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,09000427 0,10952901 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,09000427 0,10947108 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,09000427 0,10941322 ! glycogen metabolic process GO:0005977 48 35 0,000 0,09000427 0,10935543 ! pigment metabolic process GO:0042440 61 35 0,000 0,09000427 0,10929769 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,09245568 0,11221534 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,09245568 0,11215615 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,09245568 0,11209703 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,09245568 0,11203797 ! negative regulation of binding GO:0051100 58 36 0,000 0,09245568 0,11197897 ! organic ether metabolic process GO:0018904 46 36 0,000 0,09245568 0,11192004 ! tissue remodeling GO:0048771 62 36 0,000 0,09245568 0,11186116 ! neural tube development GO:0021915 50 36 0,000 0,09245568 0,11180235 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,09245568 0,1117436 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,09245568 0,11168491 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,09245568 0,11162628 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,09245568 0,11156772 ! glucan metabolic process GO:0044042 49 36 0,000 0,09245568 0,11150921 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,09490063 0,11439804 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,09490063 0,11433811 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,09490063 0,11427825 ! ion transmembrane transport GO:0034220 56 37 0,000 0,09490063 0,11421845 ! regulation of protein secretion GO:0050708 51 37 0,000 0,09490063 0,11415871 ! amino acid activation GO:0043038 52 37 0,000 0,09490063 0,11409903 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,09490063 0,11403942 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,09733913 0,11690862 ! gliogenesis GO:0042063 71 38 0,000 0,09733913 0,1168476 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,09733913 0,11678665 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,09733913 0,11672576 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,09733913 0,11666493 ! phagocytosis GO:0006909 60 38 0,000 0,09733913 0,11660417 ! mesenchymal cell development GO:0014031 64 38 0,000 0,09733913 0,11654347 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,09733913 0,11648283 ! maintenance of location in cell GO:0051651 69 38 0,000 0,09733913 0,11642226 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,09977121 0,11926911 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,09977121 0,11920715 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,09977121 0,11914526 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,09977121 0,11908343 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,09977121 0,11902167 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,09977121 0,11895996 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,09977121 0,11889833 ! male sex differentiation GO:0046661 53 39 0,000 0,09977121 0,11883675 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,09977121 0,11877524 ! chromatin remodeling GO:0006338 68 39 0,000 0,09977121 0,1187138 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,09977121 0,11865242 ! JNK cascade GO:0007254 54 39 0,000 0,09977121 0,1185911 ! developmental growth GO:0048589 62 39 0,000 0,09977121 0,11852984 ! synapse organization GO:0050808 55 39 0,000 0,09977121 0,11846865 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,10219686 0,12128627 ! response to calcium ion GO:0051592 58 40 0,000 0,10219686 0,12122372 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,10219686 0,12116123 ! regulation of tube size GO:0035150 60 40 0,000 0,10219686 0,12109881 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,10219686 0,12103645 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,10219686 0,12097416 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,10219686 0,12091193 ! peptide metabolic process GO:0006518 56 40 0,000 0,10219686 0,12084976 ! inner ear development GO:0048839 57 40 0,000 0,10219686 0,12078766 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,10219686 0,12072562 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,10219686 0,12066365 ! double-strand break repair GO:0006302 67 40 0,000 0,10219686 0,12060174 ! B cell differentiation GO:0030183 62 40 0,000 0,10219686 0,12053989 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,10219686 0,12047811 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,10219686 0,12041639 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,10461612 0,12320383 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,10461612 0,12314078 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,10461612 0,12307779 ! glucose transport GO:0015758 52 41 0,000 0,10461612 0,12301487 ! endosome transport GO:0016197 71 41 0,000 0,10461612 0,12295201 ! striated muscle contraction GO:0006941 62 41 0,000 0,10461612 0,12288922 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,10461612 0,12282649 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,10461612 0,12276382 ! biopolymer methylation GO:0043414 62 41 0,000 0,10461612 0,12270122 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,10461612 0,12263868 ! mitochondrial transport GO:0006839 60 42 0,000 0,107029 0,12540332 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,107029 0,12533947 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,107029 0,12527568 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,107029 0,12521196 ! hexose transport GO:0008645 54 42 0,000 0,107029 0,1251483 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,107029 0,12508471 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,107029 0,12502118 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,107029 0,12495772 ! excretion GO:0007588 63 42 0,000 0,107029 0,12489432 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,107029 0,12483099 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,107029 0,12476772 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,107029 0,12470451 ! regulation of cell shape GO:0008360 78 42 0,000 0,107029 0,12464137 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,10943552 0,1273794 ! leukocyte migration GO:0050900 60 43 0,000 0,10943552 0,12731497 ! neuromuscular process GO:0050905 79 43 0,000 0,10943552 0,1272506 ! activation of caspase activity GO:0006919 65 43 0,000 0,10943552 0,1271863 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,10943552 0,12712207 ! tRNA processing GO:0008033 49 43 0,000 0,10943552 0,1270579 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,10943552 0,12699379 ! vesicle organization GO:0016050 79 43 0,000 0,10943552 0,12692975 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,10943552 0,12686577 ! methylation GO:0032259 64 43 0,000 0,10943552 0,12680186 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,11183569 0,12951767 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,11183569 0,12945248 ! glycolysis GO:0006096 53 44 0,000 0,11183569 0,12938737 ! regulation of action potential GO:0001508 71 44 0,000 0,11183569 0,12932231 ! regulation of ion transport GO:0043269 57 44 0,000 0,11183569 0,12925733 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,11183569 0,12919241 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,11183569 0,12912755 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,11183569 0,12906276 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,11183569 0,12899804 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,11183569 0,12893338 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,11183569 0,12886878 ! positive regulation of cell cycle GO:0045787 77 45 0,000 0,11422952 0,1315613 ! RNA catabolic process GO:0006401 64 45 0,000 0,11422952 0,13149545 ! positive regulation of defense response GO:0031349 59 45 0,000 0,11422952 0,13142967 ! regulation of translational initiation GO:0006446 64 45 0,000 0,11422952 0,13136395 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,11422952 0,1312983 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,11422952 0,13123272 ! cell recognition GO:0008037 58 45 0,000 0,11422952 0,1311672 ! cell maturation GO:0048469 60 45 0,000 0,11422952 0,13110175 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,11422952 0,13103636 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,11661705 0,13370848 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,11661705 0,13364186 ! cell redox homeostasis GO:0045454 63 46 0,000 0,11661705 0,1335753 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,11661705 0,13350881 ! regulation of ossification GO:0030278 71 46 0,000 0,11661705 0,13344239 ! histone modification GO:0016570 68 46 0,000 0,11661705 0,13337604 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,11661705 0,13330974 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,11899827 0,13596424 ! viral infectious cycle GO:0019058 71 47 0,000 0,11899827 0,13589673 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,11899827 0,13582929 ! endocrine system development GO:0035270 83 47 0,000 0,11899827 0,13576191 ! covalent chromatin modification GO:0016569 75 47 0,000 0,11899827 0,13569461 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,11899827 0,13562736 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,11899827 0,13556019 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,11899827 0,13549308 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,11899827 0,13542604 ! chloride transport GO:0006821 67 48 0,000 0,12137321 0,13806052 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,12137321 0,13799228 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,12137321 0,1379241 ! response to temperature stimulus GO:0009266 62 48 0,000 0,12137321 0,13785599 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,12137321 0,13778795 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,12137321 0,13771997 ! gastrulation GO:0007369 73 48 0,000 0,12137321 0,13765206 ! heart morphogenesis GO:0003007 65 48 0,000 0,12137321 0,13758422 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,12137321 0,13751644 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,12137321 0,13744874 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,12137321 0,13738109 ! regulation of endocytosis GO:0030100 63 48 0,000 0,12137321 0,13731352 ! nuclear export GO:0051168 69 48 0,000 0,12137321 0,13724601 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,12137321 0,13717857 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,12137321 0,13711119 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,12374188 0,13971838 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,12374188 0,13964982 ! sensory perception of smell GO:0007608 61 49 0,000 0,12374188 0,13958133 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,12374188 0,13951291 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,12374188 0,13944455 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,12374188 0,13937626 ! germ cell development GO:0007281 68 49 0,000 0,12374188 0,13930804 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,12374188 0,13923989 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,12374188 0,1391718 ! cartilage development GO:0051216 70 49 0,000 0,12374188 0,13910378 ! maintenance of location GO:0051235 84 49 0,000 0,12374188 0,13903582 ! regulation of actin filament length GO:0030832 72 50 0,000 0,12610431 0,14162105 ! ear development GO:0043583 72 50 0,000 0,12610431 0,14155193 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,12610431 0,14148288 ! membrane fusion GO:0006944 80 50 0,000 0,12610431 0,1414139 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,12610431 0,14134498 ! positive regulation of growth GO:0045927 67 50 0,000 0,12610431 0,14127614 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,12610431 0,14120735 ! proton transport GO:0015992 75 50 0,000 0,12610431 0,14113864 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,12610431 0,14106999 ! positive regulation of secretion GO:0051047 71 51 0,000 0,1284605 0,14363595 ! hydrogen transport GO:0006818 77 51 0,000 0,1284605 0,14356615 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,1284605 0,14349643 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,1284605 0,14342677 ! positive regulation of cell migration GO:0030335 92 51 0,000 0,1284605 0,14335718 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,1284605 0,14328765 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,1284605 0,1432182 ! adult behavior GO:0030534 80 51 0,000 0,1284605 0,14314881 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,1284605 0,14307949 ! transition metal ion transport GO:0000041 74 52 0,000 0,13081047 0,14562637 ! regulation of cellular component size GO:0032535 74 52 0,000 0,13081047 0,14555592 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,13081047 0,14548553 ! aging GO:0007568 79 52 0,000 0,13081047 0,14541521 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,13081047 0,14534496 ! establishment of organelle localization GO:0051656 85 52 0,000 0,13081047 0,14527478 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,13315424 0,14780635 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,13315424 0,14773504 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,13315424 0,14766381 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,13315424 0,14759265 ! kidney development GO:0001822 90 53 0,000 0,13315424 0,14752155 ! single fertilization GO:0007338 59 53 0,000 0,13315424 0,14745053 ! cell projection assembly GO:0030031 76 53 0,000 0,13315424 0,14737957 ! amino acid transport GO:0006865 84 54 0,000 0,13549182 0,14989475 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,13549182 0,14982269 ! regulation of mitosis GO:0007088 84 54 0,000 0,13549182 0,14975069 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,13549182 0,14967877 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,13549182 0,14960691 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,13549182 0,14953512 ! detection of external stimulus GO:0009581 66 54 0,000 0,13549182 0,1494634 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,13549182 0,14939175 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,13549182 0,14932017 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,13549182 0,14924865 ! exocytosis GO:0006887 74 55 0,000 0,13782324 0,15174411 ! mesoderm development GO:0007498 76 55 0,000 0,13782324 0,1516715 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,13782324 0,15159897 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,1401485 0,15408295 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,1401485 0,15400934 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,1401485 0,15393579 ! positive regulation of cell motion GO:0051272 99 56 0,000 0,1401485 0,15386231 ! carbohydrate transport GO:0008643 74 57 0,000 0,14246762 0,15633374 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,14246762 0,15625919 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,14246762 0,15618471 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,14246762 0,1561103 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,14246762 0,15603596 ! camera-type eye development GO:0043010 88 57 0,000 0,14246762 0,1559617 ! secondary metabolic process GO:0019748 84 57 0,000 0,14246762 0,1558875 ! developmental maturation GO:0021700 75 57 0,000 0,14246762 0,15581337 ! viral reproductive process GO:0022415 87 58 0,000 0,14478062 0,15826779 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,14478062 0,1581926 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,14478062 0,15811748 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,14708751 0,16056064 ! activation of MAPK activity GO:0000187 84 59 0,000 0,14708751 0,16048448 ! lung development GO:0030324 94 59 0,000 0,14708751 0,16040838 ! actin filament organization GO:0007015 95 59 0,000 0,14708751 0,16033236 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,14708751 0,16025641 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,14708751 0,16018053 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,14938831 0,16260914 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,14938831 0,16253222 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,14938831 0,16245538 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,14938831 0,1623786 ! regulation of heart contraction GO:0008016 91 60 0,000 0,14938831 0,1623019 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,14938831 0,16222527 ! fertilization GO:0009566 68 60 0,000 0,14938831 0,16214871 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,14938831 0,16207223 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,15168304 0,1644842 ! meiosis GO:0007126 96 61 0,000 0,15168304 0,16440669 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,15168304 0,16432925 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,15168304 0,16425188 ! urogenital system development GO:0001655 101 61 0,000 0,15168304 0,16417459 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,15168304 0,16409736 ! extracellular matrix organization GO:0030198 103 61 0,000 0,15168304 0,16402021 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,15168304 0,16394314 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,15168304 0,16386613 ! amine catabolic process GO:0009310 90 62 0,000 0,15397171 0,16626053 ! neurotransmitter transport GO:0006836 81 62 0,000 0,15397171 0,16618251 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,15397171 0,16610457 ! respiratory tube development GO:0030323 99 62 0,000 0,15397171 0,16602669 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,15397171 0,16594889 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,15397171 0,16587116 ! meiotic cell cycle GO:0051321 97 62 0,000 0,15397171 0,16579351 ! organelle localization GO:0051640 96 62 0,000 0,15397171 0,16571593 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,15625434 0,168094 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,15625434 0,16801541 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,15625434 0,1679369 ! viral reproduction GO:0016032 92 63 0,000 0,15625434 0,16785846 ! regulation of lipase activity GO:0060191 109 63 0,000 0,15625434 0,1677801 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,15853093 0,17014519 ! appendage morphogenesis GO:0035107 93 64 0,000 0,15853093 0,17006583 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,15853093 0,16998655 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,15853093 0,16990734 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,15853093 0,1698282 ! hexose catabolic process GO:0019320 82 64 0,000 0,15853093 0,16974914 ! respiratory system development GO:0060541 100 64 0,000 0,15853093 0,16967015 ! adaptive immune response GO:0002250 94 64 0,000 0,15853093 0,16959123 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 0,000 0,16080152 0,17194026 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,16080152 0,17186036 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,16080152 0,17178053 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,16080152 0,17170078 ! defense response to bacterium GO:0042742 73 65 0,000 0,16080152 0,17162111 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,16080152 0,17154151 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,16080152 0,17146198 ! activation of immune response GO:0002253 83 65 0,000 0,16080152 0,17138253 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,16306611 0,17371563 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,16306611 0,17363521 ! antigen processing and presentation GO:0019882 96 66 0,000 0,16306611 0,17355486 ! axon guidance GO:0007411 99 66 0,000 0,16306611 0,17347458 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,16306611 0,17339438 ! regulation of immune effector process GO:0002697 101 66 0,000 0,16306611 0,17331425 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,16532471 0,17563364 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,16532471 0,17555256 ! acute inflammatory response GO:0002526 92 68 0,000 0,16757735 0,17786244 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,16757735 0,1777804 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,16757735 0,17769844 ! rhythmic process GO:0048511 105 68 0,000 0,16757735 0,17761655 ! inorganic anion transport GO:0015698 93 68 0,000 0,16757735 0,17753474 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,16982404 0,17983209 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,16982404 0,17974933 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,16982404 0,17966665 ! response to metal ion GO:0010038 103 70 0,000 0,1720648 0,18195358 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,1720648 0,18186996 ! humoral immune response GO:0006959 86 70 0,000 0,1720648 0,18178642 ! eye development GO:0001654 111 70 0,000 0,1720648 0,18170296 ! amine transport GO:0015837 101 70 0,000 0,1720648 0,18161957 ! positive regulation of phosphorylation GO:0042327 102 70 0,000 0,1720648 0,18153626 ! regulation of catabolic process GO:0009894 106 70 0,000 0,1720648 0,18145302 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,17429963 0,18372555 ! muscle cell differentiation GO:0042692 104 71 0,000 0,17429963 0,18364139 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,17429963 0,18355731 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,17429963 0,1834733 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,17429963 0,18338937 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,17429963 0,18330551 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 0,000 0,17652856 0,18556476 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 0,000 0,17652856 0,18547999 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,17652856 0,1853953 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,17652856 0,18531068 ! negative regulation of transport GO:0051051 116 73 0,000 0,17875161 0,18755871 ! regulation of blood pressure GO:0008217 107 73 0,000 0,17875161 0,18747319 ! tube morphogenesis GO:0035239 118 73 0,000 0,17875161 0,18738774 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,17875161 0,18730237 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,17875161 0,18721707 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,18096877 0,18945297 ! response to oxygen levels GO:0070482 137 74 0,000 0,18096877 0,18936678 ! digestion GO:0007586 97 74 0,000 0,18096877 0,18928066 ! protein import into nucleus GO:0006606 118 74 0,000 0,18096877 0,18919463 ! blood coagulation GO:0007596 116 75 0,000 0,18318008 0,19141944 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,18318008 0,19133251 ! regulation of ligase activity GO:0051340 114 75 0,000 0,18318008 0,19124566 ! nuclear import GO:0051170 121 75 0,000 0,18318008 0,19115889 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,18318008 0,1910722 ! amine biosynthetic process GO:0009309 97 76 0,000 0,18538555 0,19328502 ! tRNA metabolic process GO:0006399 95 76 0,000 0,18538555 0,19319745 ! response to unfolded protein GO:0006986 99 76 0,000 0,18538555 0,19310995 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,18538555 0,19302253 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,18758519 0,1952244 ! gland development GO:0048732 148 77 0,000 0,18758519 0,1951361 ! protein ubiquitination GO:0016567 125 77 0,000 0,18758519 0,19504789 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,18758519 0,19495975 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,18758519 0,19487169 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,18758519 0,19478371 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,18977901 0,1969728 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,18977901 0,19688395 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,18977901 0,19679519 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,19196703 0,19897439 ! cellular respiration GO:0045333 107 79 0,000 0,19196703 0,19888477 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,19196703 0,19879522 ! T cell activation GO:0042110 134 79 0,000 0,19196703 0,19870575 ! regulation of lyase activity GO:0051339 133 79 0,000 0,19196703 0,19861636 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,19196703 0,19852706 ! chromatin assembly GO:0031497 102 80 0,000 0,19414928 0,20069363 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,19414928 0,20060347 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,19414928 0,2005134 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,19414928 0,2004234 ! forebrain development GO:0030900 131 80 0,000 0,19414928 0,20033348 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,19632575 0,20248844 ! hemostasis GO:0007599 125 81 0,000 0,19632575 0,20239768 ! mRNA transport GO:0051028 121 81 0,000 0,19632575 0,202307 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,19632575 0,2022164 ! response to protein stimulus GO:0051789 111 81 0,000 0,19632575 0,20212588 ! regulation of neurological system process GO:0031644 122 81 0,000 0,19632575 0,20203545 ! vitamin metabolic process GO:0006766 103 81 0,000 0,19632575 0,20194509 ! ossification GO:0001503 134 82 0,000 0,19849647 0,20408667 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,19849647 0,20399548 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,20066145 0,20612833 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,20066145 0,20603631 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,20066145 0,20594437 ! regulation of defense response GO:0031347 117 84 0,000 0,20282071 0,20806763 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,20282071 0,20797487 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,20282071 0,20788219 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,20497425 0,20999589 ! rRNA metabolic process GO:0016072 107 85 0,000 0,20497425 0,2099024 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 0,000 0,20497425 0,20980898 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,20497425 0,20971565 ! regulation of membrane potential GO:0042391 128 85 0,000 0,20497425 0,2096224 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,20497425 0,20952924 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,20712211 0,21163076 ! nucleosome organization GO:0034728 114 87 0,000 0,20926428 0,21372462 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,20926428 0,21362976 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,20926428 0,21353498 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,20926428 0,21344029 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,20926428 0,21334568 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,20926428 0,21325115 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,21140079 0,21533296 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,21140079 0,21523764 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,21140079 0,2151424 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,21140079 0,21504724 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,21140079 0,21495217 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,21353165 0,21702289 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,21353165 0,21692703 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,21353165 0,21683126 ! leukocyte differentiation GO:0002521 143 90 0,000 0,21565687 0,21889268 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,21565687 0,21879612 ! hormone metabolic process GO:0042445 121 90 0,000 0,21565687 0,21869965 ! RNA localization GO:0006403 135 91 0,000 0,21777648 0,22075183 ! ATP metabolic process GO:0046034 137 91 0,000 0,21777648 0,22065458 ! response to virus GO:0009615 122 91 0,000 0,21777648 0,22055742 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,21989047 0,22260039 ! positive regulation of immune response GO:0050778 121 92 0,000 0,21989047 0,22250246 ! DNA recombination GO:0006310 146 92 0,000 0,21989047 0,22240461 ! sulfur metabolic process GO:0006790 118 92 0,000 0,21989047 0,22230685 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,22199888 0,22433981 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,22199888 0,22424129 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,22199888 0,22414285 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,22199888 0,2240445 ! electron transport chain GO:0022900 123 94 0,000 0,2241017 0,22606751 ! response to oxidative stress GO:0006979 141 94 0,000 0,2241017 0,2259684 ! angiogenesis GO:0001525 149 95 0,000 0,22619897 0,22798318 ! carboxylic acid transport GO:0046942 147 95 0,000 0,22619897 0,22788332 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,22829068 0,22988992 ! in utero embryonic development GO:0001701 147 96 0,000 0,22829068 0,22978931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,22829068 0,22968879 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,22829068 0,22958835 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,22829068 0,22948801 ! protein maturation GO:0051604 129 96 0,000 0,22829068 0,22938775 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,23037686 0,23138287 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,23453268 0,23545402 ! extracellular structure organization GO:0043062 156 99 0,000 0,23453268 0,23535129 ! protein import GO:0017038 156 99 0,000 0,23453268 0,23524865 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,23453268 0,2351461 ! regulation of translation GO:0006417 151 100 0,000 0,23660234 0,23711782 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,23660234 0,23701454 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,23660234 0,23691136 ! divalent metal ion transport GO:0070838 171 100 0,000 0,23660234 0,23680826 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,23660234 0,23670526 ! protein localization in organelle GO:0033365 161 100 0,000 0,23660234 0,23660234