pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/579-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! nuclear migration GO:0007097 10 5 2,000 6,113E-07 1,406E-03 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 6,113E-07 7,03E-04 GO:0031272|regulation of pseudopodium assembly, ! macrophage differentiation GO:0030225 10 6 2,000 1,219E-06 9,346E-04 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 2,127E-06 1,223E-03 ! establishment of nucleus localization GO:0040023 13 7 2,000 2,127E-06 9,785E-04 ! regulation of lipid metabolic process GO:0019216 84 56 4,000 2,902E-06 1,113E-03 ! nucleus localization GO:0051647 15 9 2,000 5,076E-06 1,668E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 7,231E-06 2,079E-03 ! filopodium assembly GO:0046847 19 11 2,000 9,914E-06 2,534E-03 ! microspike assembly GO:0030035 23 12 2,000 1,318E-05 3,032E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 4,000 2,411E-05 5,042E-03 ! interphase GO:0051325 159 88 4,000 2,696E-05 5,167E-03 ! integrin-mediated signaling pathway GO:0007229 81 49 3,000 4,359E-05 7,712E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 5,69E-05 9,348E-03 ! regulation of protein complex assembly GO:0043254 81 54 3,000 6,409E-05 9,827E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 6,675E-05 9,595E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 7,765E-05 0,01050533 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 7,765E-05 9,922E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 7,933E-05 9,603E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 8,495E-05 9,769E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 8,965E-05 9,819E-03 ! vasculogenesis GO:0001570 33 22 2,000 8,965E-05 9,373E-03 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 3,000 9,705E-05 9,705E-03 ! cell-matrix adhesion GO:0007160 114 61 3,000 1,035E-04 9,923E-03 ! negative regulation of ligase activity GO:0051352 91 61 3,000 1,035E-04 9,526E-03 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 3,000 1,035E-04 9,16E-03 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 3,000 1,035E-04 8,821E-03 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 1,172E-04 9,623E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 1,172E-04 9,291E-03 ! adaptive immune response GO:0002250 94 64 3,000 1,249E-04 9,579E-03 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 3,000 1,327E-04 9,848E-03 ! regulation of cellular ketone metabolic process GO:0010565 34 25 2,000 1,327E-04 9,541E-03 ! cell-substrate adhesion GO:0031589 121 66 3,000 1,409E-04 9,818E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 1,568E-04 0,01060856 ! protein maturation by protein folding GO:0022417 12 5 1,000 1,568E-04 0,01030545 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 1,000 1,568E-04 0,01001919 ! regulation of appetite GO:0032098 5 5 1,000 1,568E-04 9,748E-03 ! positive regulation of vasoconstriction GO:0045907 9 5 1,000 1,568E-04 9,492E-03 ! regulation of sterol transport GO:0032371 7 5 1,000 1,568E-04 9,248E-03 GO:0032374|regulation of cholesterol transport, ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 1,568E-04 9,017E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 1,568E-04 8,797E-03 ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 1,568E-04 8,588E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 1,871E-04 0,0100064 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 1,875E-04 9,799E-03 ! complement activation, classical pathway GO:0006958 36 28 2,000 1,875E-04 9,581E-03 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 2,000 2,31E-04 0,01154939 ! regulation of ligase activity GO:0051340 114 75 3,000 2,312E-04 0,01131505 ! mRNA stabilization GO:0048255 15 6 1,000 2,346E-04 0,01124238 GO:0043489|RNA stabilization, ! response to dietary excess GO:0002021 7 6 1,000 2,346E-04 0,01101295 ! eating behavior GO:0042755 6 6 1,000 2,346E-04 0,01079269 ! gas homeostasis GO:0033483 11 6 1,000 2,346E-04 0,01058107 ! regulation of meiosis GO:0040020 10 6 1,000 2,346E-04 0,01037758 GO:0051445|regulation of meiotic cell cycle, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 2,346E-04 0,01018178 GO:0031958|corticosteroid receptor signaling pathway, ! interaction with symbiont GO:0051702 8 6 1,000 2,346E-04 9,993E-03 ! adult feeding behavior GO:0008343 6 6 1,000 2,346E-04 9,812E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 2,346E-04 9,636E-03 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 2,346E-04 9,467E-03 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 2,346E-04 9,304E-03 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 3,000 2,964E-04 0,01155383 GO:0010498|proteasomal protein catabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 3,276E-04 0,01255885 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 3,276E-04 0,01235297 ! regulation of gluconeogenesis GO:0006111 7 7 1,000 3,276E-04 0,01215373 ! T-helper 1 type immune response GO:0042088 11 7 1,000 3,276E-04 0,01196081 ! regulation of response to extracellular stimulus GO:0032104 10 7 1,000 3,276E-04 0,01177392 GO:0032107|regulation of response to nutrient levels, ! vesicle fusion GO:0006906 15 7 1,000 3,276E-04 0,01159279 ! regulation of lipid transport GO:0032368 13 7 1,000 3,276E-04 0,01141714 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 3,366E-04 0,01155387 ! tissue remodeling GO:0048771 62 36 2,000 3,993E-04 0,01350551 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 2,000 4,333E-04 0,01444274 GO:0006956|complement activation, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 4,357E-04 0,0143158 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 4,357E-04 0,01411417 ! induction of positive chemotaxis GO:0050930 14 8 1,000 4,357E-04 0,01391814 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 4,357E-04 0,01372748 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 4,357E-04 0,01354197 ! regulation of vascular permeability GO:0043114 12 8 1,000 4,357E-04 0,01336141 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 4,357E-04 0,01318561 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 4,357E-04 0,01301437 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 5,067E-04 0,01494149 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 5,462E-04 0,01590289 ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 5,587E-04 0,01606358 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 1,000 5,587E-04 0,01586526 ! lung alveolus development GO:0048286 17 9 1,000 5,587E-04 0,01567179 ! positive regulation of phagocytosis GO:0050766 11 9 1,000 5,587E-04 0,01548297 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 5,587E-04 0,01529865 ! sequestering of metal ion GO:0051238 11 9 1,000 5,587E-04 0,01511866 ! localization within membrane GO:0051668 15 9 1,000 5,587E-04 0,01494286 ! regulation of response to external stimulus GO:0032101 139 96 3,000 5,933E-04 0,01568502 ! regulation of cellular component biogenesis GO:0044087 158 96 3,000 5,933E-04 0,01550678 ! protein maturation GO:0051604 129 96 3,000 5,933E-04 0,01533254 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 6,765E-04 0,01728719 ! response to insulin stimulus GO:0032868 63 43 2,000 6,765E-04 0,01709722 ! cortical actin cytoskeleton organization GO:0030866 19 10 1,000 6,966E-04 0,01741522 ! regulation of B cell proliferation GO:0030888 15 10 1,000 6,966E-04 0,01722796 ! blood vessel remodeling GO:0001974 21 10 1,000 6,966E-04 0,01704468 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 6,966E-04 0,01686527 ! regulation of bone resorption GO:0045124 24 10 1,000 6,966E-04 0,01668959 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 6,966E-04 0,01651753 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 6,966E-04 0,01634898 ! regulation of cell projection organization GO:0031344 83 44 2,000 7,239E-04 0,01681735 ! positive regulation of cell cycle GO:0045787 77 45 2,000 7,734E-04 0,01778744 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 7,734E-04 0,01761132 ! response to UV GO:0009411 75 46 2,000 8,25E-04 0,01860202 ! cortical cytoskeleton organization GO:0030865 20 11 1,000 8,492E-04 0,01896289 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 8,492E-04 0,01878055 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 8,492E-04 0,01860169 GO:0000725|recombinational repair, ! regulation of positive chemotaxis GO:0050926 17 11 1,000 8,492E-04 0,0184262 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 8,492E-04 0,018254 ! regulation of phagocytosis GO:0050764 14 11 1,000 8,492E-04 0,01808498 ! regulation of leukocyte migration GO:0002685 24 11 1,000 8,492E-04 0,01791906 ! regulation of steroid biosynthetic process GO:0050810 11 11 1,000 8,492E-04 0,01775616 ! immunoglobulin mediated immune response GO:0016064 66 48 2,000 9,346E-04 0,01936542 GO:0019724|B cell mediated immunity, ! cartilage condensation GO:0001502 18 12 1,000 1,016E-03 0,02087277 ! Golgi organization GO:0007030 18 12 1,000 1,016E-03 0,02068805 ! gland morphogenesis GO:0022612 23 12 1,000 1,016E-03 0,02050658 ! regulation of mRNA stability GO:0043488 27 12 1,000 1,016E-03 0,02032826 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 1,016E-03 0,02015302 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 1,116E-03 0,021932 ! positive regulation of cell migration GO:0030335 92 51 2,000 1,116E-03 0,02174614 ! aging GO:0007568 79 52 2,000 1,181E-03 0,02281829 ! establishment of organelle localization GO:0051656 85 52 2,000 1,181E-03 0,02262814 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 1,198E-03 0,02277397 ! lipid localization GO:0010876 24 13 1,000 1,198E-03 0,0225873 GO:0019915|lipid storage, ! organelle fusion GO:0048284 28 13 1,000 1,198E-03 0,02240366 ! endocrine pancreas development GO:0031018 19 13 1,000 1,198E-03 0,02222299 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,198E-03 0,02204521 ! regulation of RNA stability GO:0043487 28 13 1,000 1,198E-03 0,02187024 ! regulation of bone remodeling GO:0046850 90 53 2,000 1,248E-03 0,0225991 ! cell projection assembly GO:0030031 76 53 2,000 1,248E-03 0,02242254 ! regulation of tissue remodeling GO:0034103 91 54 2,000 1,317E-03 0,02349026 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 1,394E-03 0,02466626 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 1,394E-03 0,02447797 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,394E-03 0,02429253 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 1,394E-03 0,02410988 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 1,394E-03 0,02392996 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 1,394E-03 0,0237527 ! cell killing GO:0001906 20 14 1,000 1,394E-03 0,02357804 ! positive regulation of cell motion GO:0051272 99 56 2,000 1,464E-03 0,02457803 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 1,541E-03 0,02568203 ! lipid phosphorylation GO:0046834 23 15 1,000 1,605E-03 0,02654947 ! bile acid metabolic process GO:0008206 22 15 1,000 1,605E-03 0,02635983 ! regulation of vasodilation GO:0042312 24 15 1,000 1,605E-03 0,02617288 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 1,605E-03 0,02598857 ! protein maturation by peptide bond cleavage GO:0051605 76 58 2,000 1,62E-03 0,02606139 ! myeloid cell differentiation GO:0030099 85 59 2,000 1,702E-03 0,02718912 ! regulation of homeostatic process GO:0032844 105 60 2,000 1,787E-03 0,02834173 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 1,829E-03 0,02881284 ! complement activation, alternative pathway GO:0006957 16 16 1,000 1,829E-03 0,02861684 ! protein export from nucleus GO:0006611 24 16 1,000 1,829E-03 0,02842348 ! regulation of steroid metabolic process GO:0019218 21 16 1,000 1,829E-03 0,02823272 ! G1 phase GO:0051318 27 16 1,000 1,829E-03 0,0280445 ! negative regulation of translation GO:0017148 22 16 1,000 1,829E-03 0,02785878 ! lymphocyte mediated immunity GO:0002449 88 62 2,000 1,963E-03 0,02971073 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 2,000 1,963E-03 0,02951654 ! organelle localization GO:0051640 96 62 2,000 1,963E-03 0,02932487 ! memory GO:0007613 25 17 1,000 2,068E-03 0,03067903 ! inactivation of MAPK activity GO:0000188 27 17 1,000 2,068E-03 0,03048237 ! cell-substrate junction assembly GO:0007044 39 17 1,000 2,068E-03 0,03028822 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 2,068E-03 0,03009652 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 2,068E-03 0,02990723 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 2,000 2,248E-03 0,03232072 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 2,248E-03 0,03211997 ! activation of immune response GO:0002253 83 65 2,000 2,248E-03 0,0319217 ! positive regulation of DNA replication GO:0045740 29 18 1,000 2,32E-03 0,03273522 ! pancreas development GO:0031016 26 18 1,000 2,32E-03 0,03253562 ! central nervous system neuron development GO:0021954 30 18 1,000 2,32E-03 0,03233843 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 2,32E-03 0,03214362 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 2,32E-03 0,03195115 ! regulation of neuron differentiation GO:0045664 107 67 2,000 2,452E-03 0,03356704 ! acute inflammatory response GO:0002526 92 68 2,000 2,558E-03 0,03480911 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 2,586E-03 0,03498936 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 2,586E-03 0,03478475 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 2,586E-03 0,03458251 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 2,586E-03 0,03438261 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 2,586E-03 0,03418501 ! cytolysis GO:0019835 20 19 1,000 2,586E-03 0,03398967 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 2,586E-03 0,03379654 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 2,586E-03 0,0336056 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 2,586E-03 0,03341681 ! protein stabilization GO:0050821 26 19 1,000 2,586E-03 0,03323012 ! positive regulation of ligase activity GO:0051351 99 69 2,000 2,666E-03 0,03407017 ! humoral immune response GO:0006959 86 70 2,000 2,778E-03 0,03529829 ! central nervous system neuron differentiation GO:0021953 33 20 1,000 2,866E-03 0,03622002 ! positive regulation of locomotion GO:0040017 35 20 1,000 2,866E-03 0,0360221 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of B cell activation GO:0050871 31 20 1,000 2,866E-03 0,03582633 ! leukocyte mediated immunity GO:0002443 99 71 2,000 2,892E-03 0,03595608 ! regulation of peptidase activity GO:0052547 106 72 2,000 3,009E-03 0,0372115 ! response to hypoxia GO:0001666 132 72 2,000 3,009E-03 0,03701251 ! regulation of chemotaxis GO:0050920 36 21 1,000 3,16E-03 0,03865502 ! vesicle docking GO:0048278 27 21 1,000 3,16E-03 0,0384505 ! cell aging GO:0007569 32 21 1,000 3,16E-03 0,03824813 ! regulation of insulin secretion GO:0050796 26 21 1,000 3,16E-03 0,03804788 ! regulation of vasoconstriction GO:0019229 31 21 1,000 3,16E-03 0,03784971 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 3,16E-03 0,0376536 ! response to oxygen levels GO:0070482 137 74 2,000 3,252E-03 0,03855781 ! blood coagulation GO:0007596 116 75 2,000 3,378E-03 0,03984478 GO:0050817|coagulation, ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 3,467E-03 0,04067979 GO:0010810|regulation of cell-substrate adhesion, ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 3,467E-03 0,0404733 ! regulation of behavior GO:0050795 38 22 1,000 3,467E-03 0,04026889 ! membrane depolarization GO:0051899 35 22 1,000 3,467E-03 0,04006653 ! regulation of blood coagulation GO:0030193 34 22 1,000 3,467E-03 0,0398662 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 3,787E-03 0,04333372 ! interaction with host GO:0051701 37 23 1,000 3,787E-03 0,04311919 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 3,787E-03 0,04290678 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 4,121E-03 0,04645788 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 4,121E-03 0,04623125 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 4,121E-03 0,04600683 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 4,121E-03 0,04578457 ! hemostasis GO:0007599 125 81 2,000 4,196E-03 0,04639939 ! ossification GO:0001503 134 82 2,000 4,343E-03 0,0477948 GO:0060348|bone development, ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 4,467E-03 0,04892848 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of peptide secretion GO:0002791 34 25 1,000 4,467E-03 0,04869659 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 4,803E-03 0,05210429 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 4,827E-03 0,05212464 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 4,827E-03 0,05188107 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 4,827E-03 0,05163976 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 4,827E-03 0,05140069 ! regulation of coagulation GO:0050818 39 26 1,000 4,827E-03 0,05116382 ! cell cycle arrest GO:0007050 150 86 2,000 4,962E-03 0,05235264 ! membrane docking GO:0022406 39 27 1,000 5,2E-03 0,05461127 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 1,000 5,2E-03 0,05436304 ! protein processing GO:0016485 114 88 2,000 5,291E-03 0,05506022 ! regulation of neurogenesis GO:0050767 153 89 2,000 5,46E-03 0,0565633 ! negative regulation of response to external stimulus GO:0032102 37 28 1,000 5,586E-03 0,05760849 ! cell junction assembly GO:0034329 56 28 1,000 5,586E-03 0,05735131 ! positive regulation of endocytosis GO:0045807 33 28 1,000 5,586E-03 0,05709641 ! cholesterol homeostasis GO:0042632 46 28 1,000 5,586E-03 0,05684377 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 1,000 5,586E-03 0,05659336 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 5,586E-03 0,05634514 ! regulation of B cell activation GO:0050864 42 28 1,000 5,586E-03 0,0560991 ! leukocyte differentiation GO:0002521 143 90 2,000 5,632E-03 0,05631827 ! positive regulation of immune response GO:0050778 121 92 2,000 5,986E-03 0,05960116 ! cholesterol transport GO:0030301 46 30 1,000 6,395E-03 0,06339607 GO:0015918|sterol transport, ! spindle organization GO:0007051 37 30 1,000 6,395E-03 0,06312398 ! regulation of microtubule-based process GO:0032886 58 30 1,000 6,395E-03 0,06285422 ! angiogenesis GO:0001525 149 95 2,000 6,542E-03 0,0640269 ! response to light stimulus GO:0009416 153 96 2,000 6,734E-03 0,06562571 ! mammary gland development GO:0030879 57 31 1,000 6,818E-03 0,06616783 ! neutral lipid metabolic process GO:0006638 41 32 1,000 7,254E-03 0,0701017 GO:0006639|acylglycerol metabolic process, ! regulation of protein stability GO:0031647 48 32 1,000 7,254E-03 0,06980839 ! calcium-mediated signaling GO:0019722 50 32 1,000 7,254E-03 0,06951752 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 7,254E-03 0,06922907 ! regulation of body fluid levels GO:0050878 154 100 2,000 7,535E-03 0,07161118 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 7,702E-03 0,07290098 ! cell junction organization GO:0034330 63 33 1,000 7,702E-03 0,07260221 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 1,000 7,702E-03 0,07230587 ! lipid homeostasis GO:0055088 55 33 1,000 7,702E-03 0,07201195 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 8,162E-03 0,07600705 ! feeding behavior GO:0007631 45 34 1,000 8,162E-03 0,07570057 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 8,162E-03 0,07539655 ! glycerol ether metabolic process GO:0006662 44 34 1,000 8,162E-03 0,07509496 ! neuron migration GO:0001764 46 34 1,000 8,162E-03 0,07479578 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 8,162E-03 0,07449897 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 8,635E-03 0,07849951 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 8,635E-03 0,07819046 ! regulation of hormone secretion GO:0046883 48 36 1,000 9,119E-03 0,08225338 ! organic ether metabolic process GO:0018904 46 36 1,000 9,119E-03 0,08193208 ! gliogenesis GO:0042063 71 38 1,000 0,01012389 0,09060294 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,01117519 0,09962379 ! induction of apoptosis by intracellular signals GO:0008629 67 40 1,000 0,01117519 0,09923914 ! double-strand break repair GO:0006302 67 40 1,000 0,01117519 0,09885745 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,01171814 0,1032633 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 0,01227249 0,10773563 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,01227249 0,10732599 ! excretion GO:0007588 63 42 1,000 0,01227249 0,10691945 ! regulation of cell shape GO:0008360 78 42 1,000 0,01227249 0,10651598 ! activation of caspase activity GO:0006919 65 43 1,000 0,01283815 0,11100659 ! vesicle organization GO:0016050 79 43 1,000 0,01283815 0,11059084 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,01341502 0,11512894 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,01400301 0,11972832 ! regulation of ossification GO:0030278 71 46 1,000 0,01460201 0,1243875 ! endocrine system development GO:0035270 83 47 1,000 0,01521194 0,12910499 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,01521194 0,12863034 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of protein polymerization GO:0032271 71 47 1,000 0,01521194 0,12815917 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,01583269 0,13290214 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 1,000 0,01583269 0,13241886 ! regulation of DNA replication GO:0006275 75 48 1,000 0,01583269 0,13193908 ! regulation of endocytosis GO:0030100 63 48 1,000 0,01583269 0,13146277 ! nuclear export GO:0051168 69 48 1,000 0,01583269 0,13098988 ! cartilage development GO:0051216 70 49 1,000 0,01646418 0,13572621 ! maintenance of location GO:0051235 84 49 1,000 0,01646418 0,13524147 ! membrane fusion GO:0006944 80 50 1,000 0,01710631 0,14001605 ! lipid modification GO:0030258 73 50 1,000 0,01710631 0,13951954 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,01710631 0,13902654 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,01775899 0,14382279 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,01775899 0,14331815 ! adult behavior GO:0030534 80 51 1,000 0,01775899 0,14281704 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01842212 0,14763375 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,01909562 0,15249978 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,0197794 0,1574139 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,0197794 0,15687109 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01986316 0,15699403 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01986316 0,15645638 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01986316 0,1559224 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01986316 0,15539205 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01986316 0,1548653 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01986316 0,15434211 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01986316 0,15382244 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01986316 0,15330625 ! sleep GO:0030431 11 5 0,000 0,01986316 0,15279352 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01986316 0,15228421 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01986316 0,15177828 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01986316 0,15127571 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01986316 0,15077645 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01986316 0,15028047 ! tongue development GO:0043586 6 5 0,000 0,01986316 0,14978775 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01986316 0,14929825 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01986316 0,14881193 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01986316 0,14832878 ! cobalt ion transport GO:0006824 9 5 0,000 0,01986316 0,14784875 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01986316 0,14737182 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01986316 0,14689795 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01986316 0,14642713 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01986316 0,14595931 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01986316 0,14549447 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01986316 0,14503258 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01986316 0,14457362 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01986316 0,14411755 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01986316 0,14366435 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01986316 0,14321399 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01986316 0,14276645 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01986316 0,14232169 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01986316 0,1418797 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01986316 0,14144044 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01986316 0,1410039 ! malate metabolic process GO:0006108 7 5 0,000 0,01986316 0,14057004 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01986316 0,14013884 ! behavioral response to pain GO:0048266 7 5 0,000 0,01986316 0,13971029 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01986316 0,13928434 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01986316 0,13886098 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01986316 0,13844019 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01986316 0,13802194 ! mating behavior GO:0007617 6 5 0,000 0,01986316 0,13760622 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01986316 0,13719298 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01986316 0,13678223 ! rhythmic behavior GO:0007622 12 5 0,000 0,01986316 0,13637392 ! copulation GO:0007620 7 5 0,000 0,01986316 0,13596805 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01986316 0,13556458 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01986316 0,1351635 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01986316 0,13476479 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01986316 0,13436842 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01986316 0,13397438 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01986316 0,13358264 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01986316 0,13319319 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01986316 0,132806 ! response to protozoan GO:0001562 9 5 0,000 0,01986316 0,13242105 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,01986316 0,13203833 ! lymph vessel development GO:0001945 7 5 0,000 0,01986316 0,13165782 ! endochondral ossification GO:0001958 12 5 0,000 0,01986316 0,13127949 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01986316 0,13090333 ! parathyroid gland development GO:0060017 8 5 0,000 0,01986316 0,13052932 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01986316 0,13015745 ! anagen GO:0042640 6 5 0,000 0,01986316 0,12978768 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01986316 0,12942001 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01986316 0,12905442 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01986316 0,12869088 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01986316 0,12832939 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01986316 0,12796993 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01986316 0,12761247 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01986316 0,127257 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01986316 0,12690351 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01986316 0,12655198 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01986316 0,12620239 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01986316 0,12585472 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01986316 0,12550897 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01986316 0,12516511 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01986316 0,12482312 ! ovulation GO:0030728 6 5 0,000 0,01986316 0,12448301 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01986316 0,12414474 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01986316 0,1238083 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01986316 0,12347368 ! response to pH GO:0009268 9 5 0,000 0,01986316 0,12314087 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01986316 0,12280985 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01986316 0,1224806 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01986316 0,12215311 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01986316 0,12182737 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01986316 0,12150336 ! polyol catabolic process GO:0046174 7 5 0,000 0,01986316 0,12118107 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01986316 0,12086049 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01986316 0,12054159 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01986316 0,12022438 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01986316 0,11990883 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01986316 0,11959493 ! urea metabolic process GO:0019627 6 5 0,000 0,01986316 0,11928267 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01986316 0,11897204 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01986316 0,11866302 ! neutrophil activation GO:0042119 5 5 0,000 0,01986316 0,1183556 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01986316 0,11804978 GO:0060177|regulation of angiotensin metabolic process, ! response to food GO:0032094 5 5 0,000 0,01986316 0,11774552 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01986316 0,11744284 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01986316 0,1171417 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01986316 0,11684211 ! forebrain neuron development GO:0021884 7 5 0,000 0,01986316 0,11654404 ! melanosome organization GO:0032438 7 5 0,000 0,01986316 0,11624749 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01986316 0,11595245 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01986316 0,11565889 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01986316 0,11536683 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01986316 0,11507623 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01986316 0,11478709 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01986316 0,11449941 ! nucleoside transport GO:0015858 6 5 0,000 0,01986316 0,11421316 ! nucleoside salvage GO:0043174 7 5 0,000 0,01986316 0,11392834 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01986316 0,11364493 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01986316 0,11336294 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01986316 0,11308234 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01986316 0,11280312 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01986316 0,11252528 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01986316 0,1122488 ! depyrimidination GO:0045008 8 5 0,000 0,01986316 0,11197368 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01986316 0,11169991 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01986316 0,11142747 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01986316 0,11115636 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01986316 0,11088656 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01986316 0,11061807 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01986316 0,11035088 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01986316 0,11008497 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01986316 0,10982034 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01986316 0,10955699 ! monocyte differentiation GO:0030224 8 5 0,000 0,01986316 0,10929489 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01986316 0,10903404 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01986316 0,10877444 ! centrosome duplication GO:0051298 5 5 0,000 0,01986316 0,10851607 ! response to UV-C GO:0010225 6 5 0,000 0,01986316 0,10825892 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01986316 0,10800299 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01986316 0,10774826 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01986316 0,10749474 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01986316 0,1072424 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01986316 0,10699125 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01986316 0,10674127 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01986316 0,10649246 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01986316 0,1062448 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01986316 0,10599829 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01986316 0,10575292 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01986316 0,10550869 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01986316 0,10526558 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01986316 0,10502359 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01986316 0,10478271 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01986316 0,10454294 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01986316 0,10430425 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01986316 0,10406666 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01986316 0,10383014 ! neural tube patterning GO:0021532 6 5 0,000 0,01986316 0,1035947 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01986316 0,10336032 ! histone demethylation GO:0016577 9 5 0,000 0,01986316 0,10312701 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01986316 0,10289474 ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01986316 0,10266351 ! enteric nervous system development GO:0048484 8 5 0,000 0,01986316 0,10243333 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01986316 0,10220417 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01986316 0,10197603 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01986316 0,10174892 ! transcription termination GO:0006353 8 5 0,000 0,01986316 0,10152281 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01986316 0,1012977 ! plasminogen activation GO:0031639 5 5 0,000 0,01986316 0,10107359 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,01986316 0,10085047 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01986316 0,10062833 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01986316 0,10040717 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01986316 0,10018698 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01986316 0,09996775 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01986316 0,09974948 ! apical protein localization GO:0045176 6 5 0,000 0,01986316 0,09953216 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01986316 0,09931579 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01986316 0,09910035 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01986316 0,09888585 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01986316 0,09867228 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01986316 0,09845962 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01986316 0,09824788 ! glial cell migration GO:0008347 10 5 0,000 0,01986316 0,09803705 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01986316 0,09782712 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01986316 0,09761808 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01986316 0,09740994 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01986316 0,09720269 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01986316 0,09699631 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01986316 0,09679081 ! neural plate development GO:0001840 6 5 0,000 0,01986316 0,09658618 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01986316 0,09638241 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01986316 0,0961795 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01986316 0,09597744 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01986316 0,09577623 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01986316 0,09557586 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01986316 0,09537633 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01986316 0,09517763 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01986316 0,09497976 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01986316 0,0947827 ! spindle assembly GO:0051225 5 5 0,000 0,01986316 0,09458647 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01986316 0,09439104 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01986316 0,09419642 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01986316 0,0940026 ! organ regeneration GO:0031100 7 5 0,000 0,01986316 0,09380958 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01986316 0,09361734 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01986316 0,0934259 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01986316 0,09323523 GO:0055081|anion homeostasis, ! negative regulation of response to stimulus GO:0048585 80 56 1,000 0,02117741 0,0992017 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,02261543 0,10572253 ! lung development GO:0030324 94 59 1,000 0,02334922 0,10893147 ! tRNA transcription GO:0009304 11 6 0,000 0,02378886 0,11075787 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02378886 0,11053412 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02378886 0,11031127 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02378886 0,11008931 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02378886 0,10986825 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02378886 0,10964807 ! regulation of helicase activity GO:0051095 11 6 0,000 0,02378886 0,10942878 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02378886 0,10921036 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,02378886 0,10899281 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02378886 0,10877612 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02378886 0,1085603 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02378886 0,10834533 ! prostate gland development GO:0030850 9 6 0,000 0,02378886 0,1081312 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02378886 0,10791793 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02378886 0,10770549 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02378886 0,10749389 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02378886 0,10728312 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02378886 0,10707317 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02378886 0,10686404 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02378886 0,10665573 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02378886 0,10644823 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02378886 0,10624153 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,02378886 0,10603564 ! neuron adhesion GO:0007158 9 6 0,000 0,02378886 0,10583054 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,02378886 0,10562623 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02378886 0,10542272 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02378886 0,10521998 ! signal peptide processing GO:0006465 8 6 0,000 0,02378886 0,10501802 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02378886 0,10481684 ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02378886 0,10461642 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02378886 0,10441677 ! opsonization GO:0008228 8 6 0,000 0,02378886 0,10421788 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02378886 0,10401975 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02378886 0,10382237 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02378886 0,10362574 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02378886 0,10342985 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02378886 0,1032347 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02378886 0,10304028 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02378886 0,1028466 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02378886 0,10265364 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02378886 0,1024614 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02378886 0,10226989 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02378886 0,10207908 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02378886 0,10188899 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02378886 0,10169961 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02378886 0,10151093 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02378886 0,10132294 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02378886 0,10113565 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02378886 0,10094906 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02378886 0,10076315 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02378886 0,10057792 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02378886 0,10039337 ! thymic T cell selection GO:0045061 12 6 0,000 0,02378886 0,1002095 ! protein lipoylation GO:0009249 10 6 0,000 0,02378886 0,10002631 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02378886 0,09984378 ! pigment granule organization GO:0048753 11 6 0,000 0,02378886 0,09966191 ! drug transport GO:0015893 6 6 0,000 0,02378886 0,09948071 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02378886 0,09930016 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,02378886 0,09912027 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02378886 0,09894103 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02378886 0,09876244 ! histidine metabolic process GO:0006547 6 6 0,000 0,02378886 0,09858449 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02378886 0,09840717 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02378886 0,0982305 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02378886 0,09805446 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02378886 0,09787905 ! adenohypophysis development GO:0021984 10 6 0,000 0,02378886 0,09770427 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02378886 0,09753011 ! hyperosmotic response GO:0006972 8 6 0,000 0,02378886 0,09735656 ! microtubule nucleation GO:0007020 10 6 0,000 0,02378886 0,09718364 ! ER overload response GO:0006983 7 6 0,000 0,02378886 0,09701133 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02378886 0,09683963 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02378886 0,09666853 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02378886 0,09649804 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02378886 0,09632815 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02378886 0,09615886 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02378886 0,09599016 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02378886 0,09582205 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02378886 0,09565453 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02378886 0,09548759 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02378886 0,09532124 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02378886 0,09515546 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02378886 0,09499026 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02378886 0,09482563 ! neuron apoptosis GO:0051402 8 6 0,000 0,02378886 0,09466157 ! organic alcohol transport GO:0015850 9 6 0,000 0,02378886 0,09449808 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02378886 0,09433515 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02378886 0,09417279 ! male sex determination GO:0030238 9 6 0,000 0,02378886 0,09401098 ! carnitine transport GO:0015879 8 6 0,000 0,02378886 0,09384972 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02378886 0,09368902 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02378886 0,09352887 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02378886 0,09336926 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02378886 0,0932102 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02378886 0,09305168 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02378886 0,0928937 ! parturition GO:0007567 12 6 0,000 0,02378886 0,09273625 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02378886 0,09257934 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02378886 0,09242295 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02378886 0,0922671 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02378886 0,09211177 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02378886 0,09195696 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02378886 0,09180267 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02378886 0,09164889 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02378886 0,09149563 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02378886 0,09134289 ! astrocyte development GO:0014002 14 6 0,000 0,02378886 0,09119065 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02378886 0,09103892 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02378886 0,09088769 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02378886 0,09073696 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02378886 0,09058674 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02378886 0,09043701 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02378886 0,09028777 ! response to copper ion GO:0046688 9 6 0,000 0,02378886 0,09013903 ! DNA topological change GO:0006265 8 6 0,000 0,02378886 0,08999077 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02378886 0,089843 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02378886 0,08969572 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02378886 0,08954892 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02378886 0,0894026 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02378886 0,08925675 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02378886 0,08911138 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02378886 0,08896649 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02378886 0,08882206 ! hair follicle maturation GO:0048820 7 6 0,000 0,02378886 0,0886781 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02378886 0,08853461 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02378886 0,08839158 ! Schwann cell development GO:0014044 14 6 0,000 0,02378886 0,08824901 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02378886 0,08810691 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02378886 0,08796526 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02378886 0,08782406 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02378886 0,08768332 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02378886 0,08754302 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02378886 0,08740318 ! histone ubiquitination GO:0016574 7 6 0,000 0,02378886 0,08726378 ! G2 phase GO:0051319 13 6 0,000 0,02378886 0,08712482 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02378886 0,08698631 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02378886 0,08684824 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02378886 0,0867106 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02378886 0,0865734 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02378886 0,08643663 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02378886 0,0863003 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02378886 0,08616439 ! receptor internalization GO:0031623 9 6 0,000 0,02378886 0,08602891 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02378886 0,08589386 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02378886 0,08575923 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02378886 0,08562502 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02378886 0,08549123 ! protein deubiquitination GO:0016579 8 6 0,000 0,02378886 0,08535786 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02378886 0,08522491 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,02378886 0,08509236 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02378886 0,08496023 ! axonal fasciculation GO:0007413 9 6 0,000 0,02378886 0,08482851 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02378886 0,0846972 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02378886 0,08456629 ! midbrain development GO:0030901 6 6 0,000 0,02378886 0,08443579 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02378886 0,08430568 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02378886 0,08417598 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02378886 0,08404668 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02378886 0,08391777 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02378886 0,08378926 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02378886 0,08366115 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02378886 0,08353342 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02378886 0,08340608 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02378886 0,08327913 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02378886 0,08315257 ! blastocyst growth GO:0001832 15 6 0,000 0,02378886 0,08302639 ! pigment granule transport GO:0051904 12 6 0,000 0,02378886 0,08290059 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02378886 0,08277517 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02378886 0,08265013 ! catecholamine transport GO:0051937 7 6 0,000 0,02378886 0,08252547 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02378886 0,08240119 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02378886 0,08227728 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02378886 0,08215374 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02378886 0,08203057 ! protein prenylation GO:0018342 10 6 0,000 0,02378886 0,08190777 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02378886 0,08178534 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02378886 0,08166327 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,02409276 0,08258322 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,02409276 0,08246033 ! meiosis GO:0007126 96 61 1,000 0,02484594 0,08491183 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of cell growth GO:0030308 106 62 1,000 0,02560869 0,0873887 ! respiratory tube development GO:0030323 99 62 1,000 0,02560869 0,08725924 ! meiotic cell cycle GO:0051321 97 62 1,000 0,02560869 0,08713016 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,02638092 0,08962497 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,02638092 0,08949278 ! regulation of lipase activity GO:0060191 109 63 1,000 0,02638092 0,08936098 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,02716253 0,09187328 ! negative regulation of cell size GO:0045792 108 64 1,000 0,02716253 0,09173837 ! respiratory system development GO:0060541 100 64 1,000 0,02716253 0,09160385 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02769907 0,09327652 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02769907 0,09314015 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02769907 0,09300418 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02769907 0,09286861 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02769907 0,09273343 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02769907 0,09259864 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02769907 0,09246425 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02769907 0,09233024 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02769907 0,09219662 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02769907 0,09206339 ! reproductive behavior GO:0019098 12 7 0,000 0,02769907 0,09193054 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02769907 0,09179808 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02769907 0,09166599 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,02769907 0,09153429 ! oligopeptide transport GO:0006857 11 7 0,000 0,02769907 0,09140296 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02769907 0,09127201 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02769907 0,09114144 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,02769907 0,09101124 ! pericardium development GO:0060039 8 7 0,000 0,02769907 0,09088141 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02769907 0,09075195 ! fibril organization GO:0043206 13 7 0,000 0,02769907 0,09062285 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02769907 0,09049413 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,02769907 0,09036577 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02769907 0,09023777 ! lipoprotein transport GO:0042953 9 7 0,000 0,02769907 0,09011014 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02769907 0,08998286 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02769907 0,08985595 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02769907 0,08972939 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02769907 0,08960319 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02769907 0,08947734 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02769907 0,08935185 ! chemosensory behavior GO:0007635 9 7 0,000 0,02769907 0,0892267 ! microtubule bundle formation GO:0001578 8 7 0,000 0,02769907 0,08910191 ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02769907 0,08897747 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02769907 0,08885337 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02769907 0,08872962 ! reflex GO:0060004 12 7 0,000 0,02769907 0,08860621 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02769907 0,08848315 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02769907 0,08836042 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02769907 0,08823804 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02769907 0,088116 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02769907 0,08799429 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02769907 0,08787292 ! spinal cord patterning GO:0021511 7 7 0,000 0,02769907 0,08775188 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02769907 0,08763118 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02769907 0,0875108 ! adrenal gland development GO:0030325 17 7 0,000 0,02769907 0,08739076 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02769907 0,08727105 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02769907 0,08715166 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02769907 0,0870326 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02769907 0,08691387 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02769907 0,08679546 ! endosome organization GO:0007032 10 7 0,000 0,02769907 0,08667737 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02769907 0,0865596 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,02769907 0,08644215 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02769907 0,08632502 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02769907 0,08620821 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02769907 0,08609171 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02769907 0,08597553 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02769907 0,08585966 ! galactose metabolic process GO:0006012 10 7 0,000 0,02769907 0,0857441 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02769907 0,08562885 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02769907 0,08551391 ! organ growth GO:0035265 11 7 0,000 0,02769907 0,08539928 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02769907 0,08528496 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02769907 0,08517094 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02769907 0,08505723 ! retinol metabolic process GO:0042572 9 7 0,000 0,02769907 0,08494382 ! behavioral fear response GO:0001662 13 7 0,000 0,02769907 0,08483071 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,02769907 0,08471791 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02769907 0,0846054 ! rRNA modification GO:0000154 12 7 0,000 0,02769907 0,08449319 ! protein heterooligomerization GO:0051291 10 7 0,000 0,02769907 0,08438128 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02769907 0,08426966 ! response to UV-B GO:0010224 11 7 0,000 0,02769907 0,08415834 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,02769907 0,08404732 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02769907 0,08393658 ! intermediate filament organization GO:0045109 11 7 0,000 0,02769907 0,08382614 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02769907 0,08371599 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02769907 0,08360612 ! fibrinolysis GO:0042730 9 7 0,000 0,02769907 0,08349655 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,02769907 0,08338726 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02769907 0,08327826 ! B cell lineage commitment GO:0002326 17 7 0,000 0,02769907 0,08316954 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02769907 0,0830611 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02769907 0,08295295 ! response to tropane GO:0014073 13 7 0,000 0,02769907 0,08284508 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02769907 0,08273749 ! melanosome localization GO:0032400 10 7 0,000 0,02769907 0,08263018 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02769907 0,08252314 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02769907 0,08241638 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02769907 0,0823099 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02769907 0,0822037 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02769907 0,08209776 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02769907 0,0819921 ! mast cell activation GO:0045576 9 7 0,000 0,02769907 0,08188672 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02769907 0,0817816 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02769907 0,08167675 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02769907 0,08157217 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02769907 0,08146786 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02769907 0,08136381 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02769907 0,08126003 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02769907 0,08115652 ! T cell lineage commitment GO:0002360 12 7 0,000 0,02769907 0,08105326 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02769907 0,08095027 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02769907 0,08084755 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02769907 0,08074508 ! response to tumor cell GO:0002347 12 7 0,000 0,02769907 0,08064287 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02769907 0,08054092 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02769907 0,08043922 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02769907 0,08033779 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02769907 0,08023661 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02769907 0,08013568 ! diuresis GO:0030146 12 7 0,000 0,02769907 0,08003501 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02769907 0,07993459 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02769907 0,07983442 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02769907 0,0797345 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02769907 0,07963483 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02769907 0,07953541 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02769907 0,07943624 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02769907 0,07933732 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02769907 0,07923864 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02769907 0,07914021 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02769907 0,07904202 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02769907 0,07894407 ! lymph node development GO:0048535 9 7 0,000 0,02769907 0,07884637 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02769907 0,07874891 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,02769907 0,07865169 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02769907 0,0785547 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02769907 0,07845796 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02769907 0,07836146 ! ATP catabolic process GO:0006200 10 7 0,000 0,02769907 0,07826519 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02769907 0,07816916 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02769907 0,07807336 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02769907 0,0779778 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02769907 0,07788248 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02769907 0,07778738 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02769907 0,07769252 ! muscle adaptation GO:0043500 12 7 0,000 0,02769907 0,07759789 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02769907 0,07750349 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02769907 0,07740931 ! retina homeostasis GO:0001895 9 7 0,000 0,02769907 0,07731537 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02769907 0,07722166 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02769907 0,07712817 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,02769907 0,0770349 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02769907 0,07694187 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02769907 0,07684905 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02769907 0,07675646 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02769907 0,0766641 ! regulation of caspase activity GO:0043281 97 65 1,000 0,02795346 0,07727519 ! protein oligomerization GO:0051259 100 65 1,000 0,02795346 0,07718242 ! antigen processing and presentation GO:0019882 96 66 1,000 0,02875361 0,07929651 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,02956289 0,08143072 ! learning or memory GO:0007611 123 68 1,000 0,03038123 0,08358472 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03159384 0,086817 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03159384 0,0867134 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,03159384 0,08661005 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03159384 0,08650694 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03159384 0,08640408 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03159384 0,08630146 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03159384 0,08619909 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03159384 0,08609696 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03159384 0,08599507 ! phosphate transport GO:0006817 10 8 0,000 0,03159384 0,08589342 ! N-glycan processing GO:0006491 12 8 0,000 0,03159384 0,08579201 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03159384 0,08569084 ! UTP metabolic process GO:0046051 8 8 0,000 0,03159384 0,08558991 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03159384 0,08548921 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03159384 0,08538876 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03159384 0,08528853 ! succinate metabolic process GO:0006105 14 8 0,000 0,03159384 0,08518855 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,03159384 0,0850888 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03159384 0,08498928 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03159384 0,08488999 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,03159384 0,08479093 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03159384 0,08469211 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,03159384 0,08459352 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03159384 0,08449515 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03159384 0,08439702 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03159384 0,08429911 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03159384 0,08420143 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03159384 0,08410397 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03159384 0,08400674 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03159384 0,08390974 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03159384 0,08381295 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03159384 0,0837164 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03159384 0,08362006 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03159384 0,08352394 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03159384 0,08342805 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03159384 0,08333238 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03159384 0,08323692 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03159384 0,08314168 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03159384 0,08304666 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03159384 0,08295186 ! melanin metabolic process GO:0006582 12 8 0,000 0,03159384 0,08285728 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03159384 0,08276291 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03159384 0,08266875 ! macrophage activation GO:0042116 12 8 0,000 0,03159384 0,08257481 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03159384 0,08248108 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03159384 0,08238756 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,03159384 0,08229426 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03159384 0,08220117 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03159384 0,08210828 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03159384 0,08201561 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03159384 0,08192315 ! ruffle organization GO:0031529 11 8 0,000 0,03159384 0,08183089 ! osteoblast development GO:0002076 13 8 0,000 0,03159384 0,08173884 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03159384 0,081647 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03159384 0,08155537 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03159384 0,08146394 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03159384 0,08137271 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03159384 0,08128169 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03159384 0,08119087 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03159384 0,08110026 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03159384 0,08100985 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03159384 0,08091963 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03159384 0,08082962 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03159384 0,08073981 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03159384 0,0806502 ! segment specification GO:0007379 10 8 0,000 0,03159384 0,08056079 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03159384 0,08047157 ! cellular extravasation GO:0045123 11 8 0,000 0,03159384 0,08038256 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03159384 0,08029374 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03159384 0,08020511 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03159384 0,08011668 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,03159384 0,08002845 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03159384 0,07994041 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03159384 0,07985256 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03159384 0,07976491 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03159384 0,07967745 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03159384 0,07959018 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03159384 0,0795031 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03159384 0,07941621 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03159384 0,07932951 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03159384 0,079243 ! icosanoid secretion GO:0032309 12 8 0,000 0,03159384 0,07915668 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,03159384 0,07907055 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03159384 0,0789846 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03159384 0,07889884 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03159384 0,07881327 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03159384 0,07872788 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03159384 0,07864267 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03159384 0,07855766 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03159384 0,07847282 ! sterol catabolic process GO:0016127 9 8 0,000 0,03159384 0,07838817 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03159384 0,0783037 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03159384 0,07821941 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03159384 0,0781353 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03159384 0,07805138 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03159384 0,07796763 ! prophase GO:0051324 11 8 0,000 0,03159384 0,07788406 ! S phase GO:0051320 8 8 0,000 0,03159384 0,07780068 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03159384 0,07771747 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03159384 0,07763444 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03159384 0,07755158 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03159384 0,0774689 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03159384 0,0773864 ! hormone catabolic process GO:0042447 13 8 0,000 0,03159384 0,07730408 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03159384 0,07722192 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03159384 0,07713995 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03159384 0,07705815 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03159384 0,07697652 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03159384 0,07689506 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,03159384 0,07681378 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03159384 0,07673266 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03159384 0,07665172 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03159384 0,07657095 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03159384 0,07649035 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03159384 0,07640992 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03159384 0,07632965 ! regulation of embryonic development GO:0045995 16 8 0,000 0,03159384 0,07624956 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03159384 0,07616963 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03159384 0,07608988 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,03204474 0,07709508 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,03288974 0,07904535 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,03374347 0,0810125 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,03547323 0,08507656 ! regulation of developmental growth GO:0048638 13 9 0,000 0,03547323 0,08498794 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,03547323 0,0848995 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03547323 0,08481125 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03547323 0,08472318 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03547323 0,08463529 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,03547323 0,08454759 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,03547323 0,08446007 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03547323 0,08437272 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,03547323 0,08428556 ! GTP metabolic process GO:0046039 9 9 0,000 0,03547323 0,08419858 ! elastic fiber assembly GO:0048251 13 9 0,000 0,03547323 0,08411178 ! social behavior GO:0035176 14 9 0,000 0,03547323 0,08402515 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03547323 0,08393871 ! artery development GO:0060840 19 9 0,000 0,03547323 0,08385244 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03547323 0,08376635 ! regulation of glycolysis GO:0006110 15 9 0,000 0,03547323 0,08368044 ! response to pain GO:0048265 16 9 0,000 0,03547323 0,0835947 ! protein complex disassembly GO:0043241 17 9 0,000 0,03547323 0,08350913 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03547323 0,08342375 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,03547323 0,08333853 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03547323 0,08325349 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03547323 0,08316863 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03547323 0,08308394 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03547323 0,08299941 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03547323 0,08291507 ! protein targeting to ER GO:0045047 19 9 0,000 0,03547323 0,08283089 ! T cell selection GO:0045058 18 9 0,000 0,03547323 0,08274688 ! endoderm development GO:0007492 12 9 0,000 0,03547323 0,08266304 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03547323 0,08257938 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,03547323 0,08249588 ! arginine catabolic process GO:0006527 10 9 0,000 0,03547323 0,08241255 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03547323 0,08232939 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,03547323 0,0822464 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,03547323 0,08216357 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,03547323 0,08208091 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,03547323 0,08199842 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03547323 0,08191609 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03547323 0,08183393 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03547323 0,08175193 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,03547323 0,08167009 ! mannose metabolic process GO:0006013 9 9 0,000 0,03547323 0,08158842 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,03547323 0,08150692 ! receptor clustering GO:0043113 15 9 0,000 0,03547323 0,08142557 ! epithelial cell development GO:0002064 10 9 0,000 0,03547323 0,08134439 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03547323 0,08126337 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03547323 0,08118251 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03547323 0,08110181 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03547323 0,08102128 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03547323 0,0809409 ! motor axon guidance GO:0008045 14 9 0,000 0,03547323 0,08086068 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,03547323 0,08078062 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,03547323 0,08070072 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,03547323 0,08062097 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03547323 0,08054139 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03547323 0,08046196 ! DNA ligation GO:0006266 14 9 0,000 0,03547323 0,08038268 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03547323 0,08030357 ! response to amine stimulus GO:0014075 13 9 0,000 0,03547323 0,08022461 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03547323 0,0801458 ! erythrocyte development GO:0048821 11 9 0,000 0,03547323 0,08006715 ! renal water homeostasis GO:0003091 14 9 0,000 0,03547323 0,07998865 ! postreplication repair GO:0006301 11 9 0,000 0,03547323 0,07991031 ! mRNA cleavage GO:0006379 13 9 0,000 0,03547323 0,07983212 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03547323 0,07975408 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,03547323 0,0796762 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,03547323 0,07959846 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03547323 0,07952088 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03547323 0,07944345 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03547323 0,07936617 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,03547323 0,07928904 ! acid secretion GO:0046717 14 9 0,000 0,03547323 0,07921206 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03547323 0,07913523 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03547323 0,07905855 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03547323 0,07898202 ! purine base metabolic process GO:0006144 18 9 0,000 0,03547323 0,07890563 ! oocyte differentiation GO:0009994 12 9 0,000 0,03547323 0,0788294 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,03547323 0,07875331 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03547323 0,07867736 ! spleen development GO:0048536 15 9 0,000 0,03547323 0,07860156 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,03547323 0,07852591 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03547323 0,07845041 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03547323 0,07837505 ! detection of calcium ion GO:0005513 13 9 0,000 0,03547323 0,07829983 ! blastocyst formation GO:0001825 12 9 0,000 0,03547323 0,07822476 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,03547323 0,07814983 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03547323 0,07807505 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,03547323 0,07800041 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,03547323 0,07792591 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03547323 0,07785155 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03547323 0,07777733 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03547323 0,07770326 ! prepulse inhibition GO:0060134 14 9 0,000 0,03547323 0,07762933 ! embryonic placenta development GO:0001892 12 9 0,000 0,03547323 0,07755554 ! insulin secretion GO:0030073 17 9 0,000 0,03547323 0,07748188 ! response to nicotine GO:0035094 16 9 0,000 0,03547323 0,07740837 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03547323 0,077335 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03547323 0,07726177 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,03547677 0,07719638 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,03547677 0,07712341 ! negative regulation of growth GO:0045926 123 75 1,000 0,03635618 0,07896055 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,037244 0,08081245 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,03814014 0,08267891 ! gland development GO:0048732 148 77 1,000 0,03814014 0,08260106 ! protein ubiquitination GO:0016567 125 77 1,000 0,03814014 0,08252335 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,0393373 0,08503363 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,0393373 0,08495379 ! neuron fate specification GO:0048665 11 10 0,000 0,0393373 0,08487409 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,0393373 0,08479455 ! thyroid gland development GO:0030878 19 10 0,000 0,0393373 0,08471515 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,0393373 0,08463591 ! synapsis GO:0007129 13 10 0,000 0,0393373 0,08455681 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,0393373 0,08447785 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,0393373 0,08439905 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,0393373 0,08432039 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,0393373 0,08424188 ! sulfate transport GO:0008272 12 10 0,000 0,0393373 0,08416352 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,0393373 0,0840853 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,0393373 0,08400723 ! phospholipid efflux GO:0033700 16 10 0,000 0,0393373 0,0839293 ! hippocampus development GO:0021766 19 10 0,000 0,0393373 0,08385151 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,0393373 0,08377387 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,0393373 0,08369638 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,0393373 0,08361902 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,0393373 0,08354181 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,0393373 0,08346474 ! pathogenesis GO:0009405 13 10 0,000 0,0393373 0,08338782 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,0393373 0,08331103 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0393373 0,08323439 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,0393373 0,08315789 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,0393373 0,08308153 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,0393373 0,08300531 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,0393373 0,08292922 ! melanocyte differentiation GO:0030318 15 10 0,000 0,0393373 0,08285328 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,0393373 0,08277748 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,0393373 0,08270181 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,0393373 0,08262629 ! response to X-ray GO:0010165 16 10 0,000 0,0393373 0,0825509 ! B cell proliferation GO:0042100 14 10 0,000 0,0393373 0,08247564 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,0393373 0,08240053 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,0393373 0,08232555 ! forebrain cell migration GO:0021885 17 10 0,000 0,0393373 0,08225071 ! lipid digestion GO:0044241 15 10 0,000 0,0393373 0,08217601 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,0393373 0,08210144 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,0393373 0,082027 ! UV protection GO:0009650 14 10 0,000 0,0393373 0,0819527 ! entry into host cell GO:0030260 20 10 0,000 0,0393373 0,08187854 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,0393373 0,0818045 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,0393373 0,08173061 ! negative regulation of ossification GO:0030279 19 10 0,000 0,0393373 0,08165684 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,0393373 0,08158321 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,0393373 0,08150971 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,0393373 0,08143635 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,0393373 0,08136311 ! regulation of organ growth GO:0046620 11 10 0,000 0,0393373 0,08129001 ! response to dsRNA GO:0043331 18 10 0,000 0,0393373 0,08121704 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,0393373 0,0811442 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,0393373 0,08107149 ! embryonic axis specification GO:0000578 12 10 0,000 0,0393373 0,08099891 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,0393373 0,08092646 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,0393373 0,08085414 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,0393373 0,08078195 ! cranial nerve development GO:0021545 12 10 0,000 0,0393373 0,08070989 ! fucose catabolic process GO:0019317 16 10 0,000 0,0393373 0,08063795 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,0393373 0,08056615 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,0393373 0,08049447 ! protein sumoylation GO:0016925 12 10 0,000 0,0393373 0,08042292 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,0393373 0,08035149 ! zymogen activation GO:0031638 14 10 0,000 0,0393373 0,0802802 ! salivary gland development GO:0007431 22 10 0,000 0,0393373 0,08020903 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,0393373 0,08013798 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,0393373 0,08006706 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,0393373 0,07999627 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,0393373 0,0799256 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,0393373 0,07985506 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,0393373 0,07978464 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,0393373 0,07971435 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,0393373 0,07964417 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,0393373 0,07957413 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,0393373 0,0795042 ! detection of bacterium GO:0016045 10 10 0,000 0,0393373 0,0794344 ! embryonic gut development GO:0048566 11 10 0,000 0,0393373 0,07936472 ! activation of innate immune response GO:0002218 10 10 0,000 0,0393373 0,07929516 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,0393373 0,07922573 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,0393373 0,07915642 ! developmental induction GO:0031128 13 10 0,000 0,0393373 0,07908722 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,0393373 0,07901815 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,0393373 0,0789492 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,0393373 0,07888037 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,0393373 0,07881166 ! chromatin assembly GO:0031497 102 80 1,000 0,04087771 0,08182657 GO:0006334|nucleosome assembly, ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,04180636 0,08361272 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,04180636 0,08354007 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,04180636 0,08346755 GO:0002696|positive regulation of leukocyte activation, ! rRNA transcription GO:0009303 17 11 0,000 0,04318611 0,08614748 ! respiratory burst GO:0045730 14 11 0,000 0,04318611 0,08607283 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04318611 0,08599831 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04318611 0,08592391 ! virus-host interaction GO:0019048 17 11 0,000 0,04318611 0,08584965 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04318611 0,08577551 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04318611 0,0857015 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,04318611 0,08562762 ! mating GO:0007618 14 11 0,000 0,04318611 0,08555387 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,04318611 0,08548024 ! T cell proliferation GO:0042098 20 11 0,000 0,04318611 0,08540674 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,04318611 0,08533337 ! bone resorption GO:0045453 16 11 0,000 0,04318611 0,08526012 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04318611 0,085187 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04318611 0,085114 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04318611 0,08504113 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,04318611 0,08496839 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04318611 0,08489576 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04318611 0,08482326 ! syncytium formation GO:0006949 15 11 0,000 0,04318611 0,08475089 ! plasma membrane organization GO:0007009 18 11 0,000 0,04318611 0,08467864 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04318611 0,08460651 ! focal adhesion formation GO:0048041 24 11 0,000 0,04318611 0,0845345 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04318611 0,08446262 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04318611 0,08439086 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,04318611 0,08431922 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04318611 0,0842477 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04318611 0,08417631 ! adult heart development GO:0007512 11 11 0,000 0,04318611 0,08410503 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,04318611 0,08403388 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,04318611 0,08396284 ! temperature homeostasis GO:0001659 16 11 0,000 0,04318611 0,08389193 ! L-glutamate transport GO:0015813 16 11 0,000 0,04318611 0,08382113 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04318611 0,08375046 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04318611 0,0836799 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04318611 0,08360946 ! stem cell development GO:0048864 29 11 0,000 0,04318611 0,08353914 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04318611 0,08346894 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04318611 0,08339886 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04318611 0,0833289 ! vasoconstriction GO:0042310 15 11 0,000 0,04318611 0,08325905 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04318611 0,08318932 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04318611 0,0831197 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04318611 0,0830502 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04318611 0,08298082 ! ribosome assembly GO:0042255 13 11 0,000 0,04318611 0,08291156 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04318611 0,0828424 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04318611 0,08277337 ! chromatin silencing GO:0006342 19 11 0,000 0,04318611 0,08270445 ! nucleosome positioning GO:0016584 13 11 0,000 0,04318611 0,08263564 ! T cell homeostasis GO:0043029 20 11 0,000 0,04318611 0,08256695 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04318611 0,08249837 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04318611 0,08242991 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04318611 0,08236156 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04318611 0,08229332 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04318611 0,0822252 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04318611 0,08215719 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04318611 0,08208929 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04318611 0,08202151 ! male genitalia development GO:0030539 13 11 0,000 0,04318611 0,08195383 ! cholesterol efflux GO:0033344 19 11 0,000 0,04318611 0,08188627 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,04318611 0,08181882 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04318611 0,08175148 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04318611 0,08168425 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,04318611 0,08161713 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,04318611 0,08155012 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04318611 0,08148322 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,04318611 0,08141643 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,04318611 0,08134975 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04318611 0,08128318 ! lysogeny GO:0030069 18 11 0,000 0,04318611 0,08121672 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04318611 0,08115036 ! acrosome reaction GO:0007340 13 11 0,000 0,04318611 0,08108412 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,04368738 0,08195838 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,0446396 0,08367651 ! protein-DNA complex assembly GO:0065004 107 84 1,000 0,0446396 0,08360837 ! sterol metabolic process GO:0016125 120 84 1,000 0,0446396 0,08354034 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,04559952 0,0852674 ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,04559952 0,08519814 ! regulation of membrane potential GO:0042391 128 85 1,000 0,04559952 0,08512898 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,04656708 0,08686479 ! lactation GO:0007595 20 12 0,000 0,04701971 0,08763804 ! reproductive cellular process GO:0048610 14 12 0,000 0,04701971 0,08756708 ! tRNA modification GO:0006400 14 12 0,000 0,04701971 0,08749623 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04701971 0,0874255 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04701971 0,08735488 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,04701971 0,08728438 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04701971 0,08721399 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,04701971 0,08714371 ! non-recombinational repair GO:0000726 19 12 0,000 0,04701971 0,08707354 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04701971 0,08700349 ! peroxisomal transport GO:0043574 21 12 0,000 0,04701971 0,08693355 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,04701971 0,08686373 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04701971 0,08679401 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04701971 0,08672441 ! heart looping GO:0001947 15 12 0,000 0,04701971 0,08665492 ! palate development GO:0060021 15 12 0,000 0,04701971 0,08658554 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,04701971 0,08651627 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04701971 0,08644712 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,04701971 0,08637807 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04701971 0,08630913 ! arginine metabolic process GO:0006525 13 12 0,000 0,04701971 0,0862403 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04701971 0,08617159 ! methionine metabolic process GO:0006555 13 12 0,000 0,04701971 0,08610298 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04701971 0,08603448 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,04701971 0,08596609 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,04701971 0,08589781 ! monoamine transport GO:0015844 13 12 0,000 0,04701971 0,08582964 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04701971 0,08576157 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,04701971 0,08569362 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04701971 0,08562577 ! L-amino acid transport GO:0015807 20 12 0,000 0,04701971 0,08555802 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04701971 0,08549039 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04701971 0,08542286 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04701971 0,08535544 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04701971 0,08528812 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04701971 0,08522092 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04701971 0,08515381 ! cerebellum development GO:0021549 13 12 0,000 0,04701971 0,08508682 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04701971 0,08501992 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,04701971 0,08495314 ! histone acetylation GO:0016573 23 12 0,000 0,04701971 0,08488645 ! histone methylation GO:0016571 15 12 0,000 0,04701971 0,08481988 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04701971 0,0847534 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04701971 0,08468703 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,04701971 0,08462077 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04701971 0,08455461 ! response to gamma radiation GO:0010332 20 12 0,000 0,04701971 0,08448855 ! regulation of epidermis development GO:0045682 17 12 0,000 0,04701971 0,08442259 ! intestinal absorption GO:0050892 19 12 0,000 0,04701971 0,08435674 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04701971 0,08429099 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04701971 0,08422534 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04701971 0,0841598 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04701971 0,08409436 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04701971 0,08402902 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04701971 0,08396378 ! response to cold GO:0009409 14 12 0,000 0,04701971 0,08389864 ! nucleosome organization GO:0034728 114 87 1,000 0,0475422 0,08476516 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,0475422 0,0846995 GO:0060538|skeletal muscle organ development, ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,0495148 0,08814554 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,05051214 0,08985144 ! hormone metabolic process GO:0042445 121 90 1,000 0,05051214 0,08978201 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,05083818 0,09029175 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,05083818 0,09022208 ! cGMP metabolic process GO:0046068 16 13 0,000 0,05083818 0,09015252 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,05083818 0,09008306 ! water transport GO:0006833 17 13 0,000 0,05083818 0,09001372 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,05083818 0,08994447 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,05083818 0,08987534 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,05083818 0,08980631 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,05083818 0,08973739 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,05083818 0,08966857 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,05083818 0,08959986 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,05083818 0,08953125 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,05083818 0,08946275 ! response to hexose stimulus GO:0009746 19 13 0,000 0,05083818 0,08939436 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,05083818 0,08932606 ! glutamate metabolic process GO:0006536 18 13 0,000 0,05083818 0,08925788 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,05083818 0,08918979 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,05083818 0,08912181 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,05083818 0,08905393 ! NAD metabolic process GO:0019674 21 13 0,000 0,05083818 0,08898616 ! exocrine system development GO:0035272 27 13 0,000 0,05083818 0,08891849 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,05083818 0,08885092 ! bone mineralization GO:0030282 15 13 0,000 0,05083818 0,08878346 ! regulation of exocytosis GO:0017157 17 13 0,000 0,05083818 0,0887161 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,05083818 0,08864884 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,05083818 0,08858168 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,05083818 0,08851462 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,05083818 0,08844767 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,05083818 0,08838081 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,05083818 0,08831406 ! genitalia development GO:0048806 15 13 0,000 0,05083818 0,08824741 ! regulation of cellular pH GO:0030641 20 13 0,000 0,05083818 0,08818086 ! cellular pigmentation GO:0033059 24 13 0,000 0,05083818 0,08811441 ! tissue regeneration GO:0042246 21 13 0,000 0,05083818 0,08804805 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,05083818 0,0879818 ! cofactor transport GO:0051181 19 13 0,000 0,05083818 0,08791565 ! NADP metabolic process GO:0006739 18 13 0,000 0,05083818 0,0878496 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,05083818 0,08778365 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,05083818 0,08771779 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05083818 0,08765204 ! gas transport GO:0015669 18 13 0,000 0,05083818 0,08758638 ! heme biosynthetic process GO:0006783 20 13 0,000 0,05083818 0,08752082 ! regulation of axon extension GO:0030516 23 13 0,000 0,05083818 0,08745536 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,05083818 0,08739 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,05083818 0,08732473 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,05083818 0,08725956 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,05083818 0,08719449 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,05083818 0,08712952 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,05083818 0,08706464 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,05252853 0,08989258 ! DNA recombination GO:0006310 146 92 1,000 0,05252853 0,08982574 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,05354745 0,09150009 ! response to oxidative stress GO:0006979 141 94 1,000 0,05457341 0,09318399 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,05464157 0,09323116 ! superoxide anion generation GO:0042554 18 14 0,000 0,05464157 0,09316205 ! neuron maturation GO:0042551 21 14 0,000 0,05464157 0,09309304 ! regulation of S phase GO:0033261 18 14 0,000 0,05464157 0,09302413 ! myotube differentiation GO:0014902 21 14 0,000 0,05464157 0,09295533 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,05464157 0,09288662 ! inositol metabolic process GO:0006020 20 14 0,000 0,05464157 0,09281802 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,05464157 0,09274952 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,05464157 0,09268112 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,05464157 0,09261282 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,05464157 0,09254463 ! gene silencing by RNA GO:0031047 20 14 0,000 0,05464157 0,09247653 ! response to cAMP GO:0051591 19 14 0,000 0,05464157 0,09240853 ! limbic system development GO:0021761 25 14 0,000 0,05464157 0,09234063 ! startle response GO:0001964 21 14 0,000 0,05464157 0,09227284 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,05464157 0,09220514 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,05464157 0,09213754 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,05464157 0,09207004 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,05464157 0,09200264 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,05464157 0,09193533 ! glycine metabolic process GO:0006544 22 14 0,000 0,05464157 0,09186813 ! pituitary gland development GO:0021983 23 14 0,000 0,05464157 0,09180102 ! cellular response to starvation GO:0009267 21 14 0,000 0,05464157 0,09173402 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,05464157 0,09166711 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,05464157 0,09160029 ! regulation of heart rate GO:0002027 23 14 0,000 0,05464157 0,09153358 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,05464157 0,09146696 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,05464157 0,09140044 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,05464157 0,09133401 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,05464157 0,09126768 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,05464157 0,09120145 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,05464157 0,09113532 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,05464157 0,09106928 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,05464157 0,09100333 ! axon cargo transport GO:0008088 27 14 0,000 0,05464157 0,09093748 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,05464157 0,09087173 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,05464157 0,09080607 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,05464157 0,09074051 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,05464157 0,09067504 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,05464157 0,09060966 ! mRNA splice site selection GO:0006376 26 14 0,000 0,05464157 0,09054438 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,05464157 0,09047919 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,05464157 0,0904141 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,05464157 0,0903491 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,05464157 0,0902842 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,05464157 0,09021938 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,05464157 0,09015466 ! muscle maintenance GO:0046716 19 14 0,000 0,05464157 0,09009004 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,05464157 0,0900255 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,05464157 0,08996106 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,05464157 0,08989671 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,05464157 0,08983245 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,05464157 0,08976829 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,05464157 0,08970421 ! cilium assembly GO:0042384 20 14 0,000 0,05464157 0,08964023 ! peptide hormone secretion GO:0030072 23 14 0,000 0,05464157 0,08957634 ! in utero embryonic development GO:0001701 147 96 1,000 0,05664618 0,09279645 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,05664618 0,09273041 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,05842993 0,09558238 ! positive regulation of cell size GO:0045793 20 15 0,000 0,05842993 0,09551445 ! metencephalon development GO:0022037 19 15 0,000 0,05842993 0,09544661 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,05842993 0,09537887 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,05842993 0,09531123 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,05842993 0,09524368 ! skin development GO:0043588 25 15 0,000 0,05842993 0,09517623 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,05842993 0,09510887 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,05842993 0,09504161 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,05842993 0,09497444 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,05842993 0,09490737 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,05842993 0,09484039 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,05842993 0,09477351 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,05842993 0,09470672 ! adult walking behavior GO:0007628 25 15 0,000 0,05842993 0,09464002 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,05842993 0,09457342 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,05842993 0,09450691 ! myoblast differentiation GO:0045445 27 15 0,000 0,05842993 0,0944405 ! centrosome cycle GO:0007098 16 15 0,000 0,05842993 0,09437418 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,05842993 0,09430795 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,05842993 0,09424182 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,05842993 0,09417578 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,05842993 0,09410983 ! cerebral cortex development GO:0021987 29 15 0,000 0,05842993 0,09404397 ! response to osmotic stress GO:0006970 22 15 0,000 0,05842993 0,0939782 ! vesicle coating GO:0006901 25 15 0,000 0,05842993 0,09391253 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,05842993 0,09384695 ! DNA integration GO:0015074 22 15 0,000 0,05842993 0,09378146 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,05842993 0,09371606 ! peptide secretion GO:0002790 27 15 0,000 0,05842993 0,09365075 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,05842993 0,09358554 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,05842993 0,09352041 ! neuron recognition GO:0008038 22 15 0,000 0,05842993 0,09345538 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,05842993 0,09339043 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,05842993 0,09332558 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,05842993 0,09326081 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,05842993 0,09319614 ! biomineral formation GO:0031214 18 15 0,000 0,05842993 0,09313155 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,05842993 0,09306706 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,05842993 0,09300265 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,05842993 0,09293833 ! dopamine metabolic process GO:0042417 30 15 0,000 0,05842993 0,09287411 ! organic cation transport GO:0015695 19 15 0,000 0,05842993 0,09280997 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,05842993 0,09274592 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,05842993 0,09268195 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,05842993 0,09261808 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,05842993 0,09255429 ! defense response to virus GO:0051607 27 15 0,000 0,05842993 0,09249059 ! peptide hormone processing GO:0016486 19 15 0,000 0,05842993 0,09242698 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,05842993 0,09236346 ! calcium ion transport GO:0006816 167 99 1,000 0,05980645 0,09447447 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,05980645 0,09440963 ! regulation of translation GO:0006417 151 100 1,000 0,06087322 0,09602771 ! divalent metal ion transport GO:0070838 171 100 1,000 0,06087322 0,09596189 ! protein secretion GO:0009306 27 16 0,000 0,06220332 0,09799154 ! hormone secretion GO:0046879 25 16 0,000 0,06220332 0,09792446 ! bone remodeling GO:0046849 24 16 0,000 0,06220332 0,09785748 ! endothelial cell migration GO:0043542 22 16 0,000 0,06220332 0,0977906 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,06220332 0,0977238 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,06220332 0,09765709 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06220332 0,09759048 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,06220332 0,09752396 ! glial cell development GO:0021782 24 16 0,000 0,06220332 0,09745752 ! patterning of blood vessels GO:0001569 24 16 0,000 0,06220332 0,09739118 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,06220332 0,09732493 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,06220332 0,09725876 ! protein polyubiquitination GO:0000209 26 16 0,000 0,06220332 0,09719269 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,06220332 0,09712671 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,06220332 0,09706082 ! fructose metabolic process GO:0006000 20 16 0,000 0,06220332 0,09699501 ! regulation of protein binding GO:0043393 27 16 0,000 0,06220332 0,0969293 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,06220332 0,09686367 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,06220332 0,09679813 ! negative regulation of immune response GO:0050777 28 16 0,000 0,06220332 0,09673269 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,06220332 0,09666733 ! DNA replication initiation GO:0006270 25 16 0,000 0,06220332 0,09660205 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,06220332 0,09653687 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,06220332 0,09647177 ! diencephalon development GO:0021536 25 16 0,000 0,06220332 0,09640677 ! oogenesis GO:0048477 23 16 0,000 0,06220332 0,09634185 ! neural crest cell migration GO:0001755 24 16 0,000 0,06220332 0,09627701 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,06220332 0,09621227 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,06220332 0,09614761 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,06220332 0,09608304 ! steroid catabolic process GO:0006706 22 16 0,000 0,06220332 0,09601855 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,06220332 0,09595415 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,06220332 0,09588984 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,06220332 0,09582561 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,06220332 0,09576147 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,06220332 0,09569742 ! sperm-egg recognition GO:0035036 16 16 0,000 0,06220332 0,09563345 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,06220332 0,09556957 ! nerve development GO:0021675 18 16 0,000 0,06220332 0,09550577 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,06220332 0,09544206 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,06220332 0,09537843 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,06596181 0,10107406 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,06596181 0,10100677 ! negative regulation of defense response GO:0031348 19 17 0,000 0,06596181 0,10093957 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,06596181 0,10087245 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,06596181 0,10080543 ! glycerol metabolic process GO:0006071 20 17 0,000 0,06596181 0,10073849 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,06596181 0,10067164 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,06596181 0,10060489 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,06596181 0,10053822 ! signal complex assembly GO:0007172 29 17 0,000 0,06596181 0,10047163 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,06596181 0,10040514 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,06596181 0,10033873 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,06596181 0,10027242 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,06596181 0,10020619 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,06596181 0,10014004 ! keratinization GO:0031424 17 17 0,000 0,06596181 0,10007399 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,06596181 0,10000802 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,06596181 0,09994214 ! retinoid metabolic process GO:0001523 22 17 0,000 0,06596181 0,09987634 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,06596181 0,09981064 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,06596181 0,09974501 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,06596181 0,09967948 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,06596181 0,09961403 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,06596181 0,09954867 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,06596181 0,09948339 ! membrane budding GO:0006900 29 17 0,000 0,06596181 0,0994182 ! heme metabolic process GO:0042168 27 17 0,000 0,06596181 0,09935309 ! actin filament bundle formation GO:0051017 26 17 0,000 0,06596181 0,09928807 ! neuromuscular junction development GO:0007528 23 17 0,000 0,06596181 0,09922313 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,06596181 0,09915828 ! body fluid secretion GO:0007589 27 17 0,000 0,06596181 0,09909351 ! stem cell differentiation GO:0048863 36 17 0,000 0,06596181 0,09902883 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,06596181 0,09896423 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,06596181 0,09889972 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,06596181 0,09883529 ! sensory perception of pain GO:0019233 23 17 0,000 0,06596181 0,09877094 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,06596181 0,09870668 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,06596181 0,0986425 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,06596181 0,09857841 ! synaptogenesis GO:0007416 24 17 0,000 0,06596181 0,09851439 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,06596181 0,09845047 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,06596181 0,09838662 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,06596181 0,09832286 ! cell-cell junction organization GO:0045216 25 17 0,000 0,06596181 0,09825918 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,06596181 0,09819558 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,06596181 0,09813206 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,06596181 0,09806863 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,06596181 0,09800528 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,06596181 0,09794201 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,06970545 0,1034339 ! positive regulation of translation GO:0045727 28 18 0,000 0,06970545 0,10336721 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,06970545 0,1033006 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,06970545 0,10323409 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,06970545 0,10316766 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,06970545 0,10310131 ! cAMP metabolic process GO:0046058 33 18 0,000 0,06970545 0,10303505 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,06970545 0,10296888 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,06970545 0,10290278 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,06970545 0,10283678 ! axis specification GO:0009798 26 18 0,000 0,06970545 0,10277086 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,06970545 0,10270502 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,06970545 0,10263927 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,06970545 0,1025736 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,06970545 0,10250802 ! glutamine metabolic process GO:0006541 23 18 0,000 0,06970545 0,10244252 ! response to retinoic acid GO:0032526 25 18 0,000 0,06970545 0,1023771 ! pigmentation during development GO:0048066 31 18 0,000 0,06970545 0,10231177 ! fucose metabolic process GO:0006004 26 18 0,000 0,06970545 0,10224652 ! response to fungus GO:0009620 19 18 0,000 0,06970545 0,10218135 ! peptide cross-linking GO:0018149 31 18 0,000 0,06970545 0,10211627 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,06970545 0,10205127 ! heart process GO:0003015 27 18 0,000 0,06970545 0,10198635 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,06970545 0,10192151 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,06970545 0,10185676 ! visual learning GO:0008542 35 18 0,000 0,06970545 0,10179209 ! somitogenesis GO:0001756 24 18 0,000 0,06970545 0,1017275 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,06970545 0,10166299 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,06970545 0,10159857 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,06970545 0,10153422 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,06970545 0,10146996 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,06970545 0,10140578 ! vitamin transport GO:0051180 24 18 0,000 0,06970545 0,10134168 ! hormone transport GO:0009914 27 18 0,000 0,06970545 0,10127766 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,06970545 0,10121372 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,06970545 0,10114987 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,06970545 0,10108609 ! cell-cell recognition GO:0009988 20 18 0,000 0,06970545 0,10102239 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,06970545 0,10095878 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,06970545 0,10089524 ! regulation of glucose import GO:0046324 21 18 0,000 0,06970545 0,10083179 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,06970545 0,10076841 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,06970545 0,10070511 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,06970545 0,1006419 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,06970545 0,10057876 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,0734343 0,10589272 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,0734343 0,10582637 ! positive regulation of ossification GO:0045778 30 19 0,000 0,0734343 0,10576011 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,0734343 0,10569392 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,0734343 0,10562782 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,0734343 0,10556181 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,0734343 0,10549587 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,0734343 0,10543002 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,0734343 0,10536425 ! regeneration GO:0031099 32 19 0,000 0,0734343 0,10529856 ! response to alkaloid GO:0043279 32 19 0,000 0,0734343 0,10523295 ! sensory perception of taste GO:0050909 23 19 0,000 0,0734343 0,10516743 ! smooth muscle contraction GO:0006939 36 19 0,000 0,0734343 0,10510199 ! peroxisome organization GO:0007031 29 19 0,000 0,0734343 0,10503662 ! digestive system process GO:0022600 30 19 0,000 0,0734343 0,10497134 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,0734343 0,10490614 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,0734343 0,10484103 ! response to vitamin A GO:0033189 26 19 0,000 0,0734343 0,10477599 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,0734343 0,10471103 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,0734343 0,10464615 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,0734343 0,10458136 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,0734343 0,10451664 ! response to starvation GO:0042594 30 19 0,000 0,0734343 0,104452 ! sex determination GO:0007530 29 19 0,000 0,0734343 0,10438745 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,0734343 0,10432297 ! plasma membrane fusion GO:0045026 23 19 0,000 0,0734343 0,10425857 ! renal system process GO:0003014 35 19 0,000 0,0734343 0,10419426 ! vasodilation GO:0042311 33 19 0,000 0,0734343 0,10413002 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,0734343 0,10406586 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,0734343 0,10400178 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,0734343 0,10393778 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,0734343 0,10387386 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,0734343 0,10381001 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,0734343 0,10374625 ! sarcomere organization GO:0045214 23 19 0,000 0,0734343 0,10368256 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,0734343 0,10361895 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,0734343 0,10355542 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,0734343 0,10349197 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,0734343 0,10342859 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,0734343 0,10336529 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,0734343 0,10330207 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,07714842 0,10846049 ! iron ion transport GO:0006826 37 20 0,000 0,07714842 0,10839423 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,07714842 0,10832806 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,07714842 0,10826196 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,07714842 0,10819595 ! response to vitamin GO:0033273 29 20 0,000 0,07714842 0,10813002 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,07714842 0,10806416 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,07714842 0,10799839 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,07714842 0,1079327 ! spinal cord development GO:0021510 31 20 0,000 0,07714842 0,10786709 ! response to ethanol GO:0045471 37 20 0,000 0,07714842 0,10780155 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,07714842 0,1077361 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,07714842 0,10767073 ! chromosome condensation GO:0030261 31 20 0,000 0,07714842 0,10760543 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,07714842 0,10754022 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,07714842 0,10747508 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,07714842 0,10741002 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,07714842 0,10734504 ! pallium development GO:0021543 38 20 0,000 0,07714842 0,10728014 ! DNA modification GO:0006304 28 20 0,000 0,07714842 0,10721532 ! collagen fibril organization GO:0030199 45 20 0,000 0,07714842 0,10715058 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,07714842 0,10708591 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,07714842 0,10702133 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,07714842 0,10695682 ! collagen catabolic process GO:0030574 25 20 0,000 0,07714842 0,10689238 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,07714842 0,10682803 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,07714842 0,10676375 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,07714842 0,10669955 ! alditol metabolic process GO:0019400 24 20 0,000 0,07714842 0,10663543 ! actin filament-based movement GO:0030048 34 20 0,000 0,07714842 0,10657139 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,08084786 0,11161469 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,08084786 0,11154773 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,08084786 0,11148086 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,08084786 0,11141406 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,08084786 0,11134735 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,08084786 0,11128071 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,08084786 0,11121416 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,08084786 0,11114768 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,08084786 0,11108128 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,08084786 0,11101497 ! protein amino acid acylation GO:0043543 37 21 0,000 0,08084786 0,11094873 ! phototransduction GO:0007602 25 21 0,000 0,08084786 0,11088257 ! dendrite development GO:0016358 35 21 0,000 0,08084786 0,11081649 ! visual behavior GO:0007632 39 21 0,000 0,08084786 0,11075049 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,08084786 0,11068456 ! ovarian follicle development GO:0001541 30 21 0,000 0,08084786 0,11061872 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,08084786 0,11055295 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,08084786 0,11048727 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,08084786 0,11042166 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,08084786 0,11035612 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,08084786 0,11029067 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,08084786 0,11022529 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,08084786 0,11015999 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,08084786 0,11009477 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,08084786 0,11002963 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,08084786 0,10996456 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,08084786 0,10989957 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,08084786 0,10983465 ! fatty acid transport GO:0015908 30 21 0,000 0,08084786 0,10976982 ! immunoglobulin production GO:0002377 33 21 0,000 0,08084786 0,10970505 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,08084786 0,10964037 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,08084786 0,10957576 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,08084786 0,10951123 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,08084786 0,10944677 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,08084786 0,10938239 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,08084786 0,10931809 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,08084786 0,10925386 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,08084786 0,10918971 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,08084786 0,10912563 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,08084786 0,10906162 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,08084786 0,1089977 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,08084786 0,10893384 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,08084786 0,10887006 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,08084786 0,10880636 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,08453268 0,11369892 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,08453268 0,11363247 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,08453268 0,1135661 ! viral genome replication GO:0019079 29 22 0,000 0,08453268 0,1134998 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,08453268 0,11343358 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,08453268 0,11336744 ! leukocyte adhesion GO:0007159 38 22 0,000 0,08453268 0,11330137 ! molting cycle process GO:0022404 40 22 0,000 0,08453268 0,11323538 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,08453268 0,11316947 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,08453268 0,11310364 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,08453268 0,11303788 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,08453268 0,1129722 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,08453268 0,11290659 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,08453268 0,11284106 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,08453268 0,11277561 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,08453268 0,11271023 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,08453268 0,11264493 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,08453268 0,11257971 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,08453268 0,11251456 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,08453268 0,11244948 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,08453268 0,11238448 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,08453268 0,11231956 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,08453268 0,11225471 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,08453268 0,11218993 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,08453268 0,11212523 ! blastocyst development GO:0001824 37 22 0,000 0,08453268 0,11206061 ! neural tube closure GO:0001843 33 22 0,000 0,08453268 0,11199606 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,08453268 0,11193158 ! protein tetramerization GO:0051262 39 22 0,000 0,08453268 0,11186718 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,08820293 0,11665713 ! neuron fate commitment GO:0048663 32 23 0,000 0,08820293 0,11659009 ! embryonic pattern specification GO:0009880 31 23 0,000 0,08820293 0,11652312 ! myelination GO:0042552 35 23 0,000 0,08820293 0,11645623 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,08820293 0,11638941 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,08820293 0,11632268 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,08820293 0,11625602 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,08820293 0,11618943 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,08820293 0,11612292 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,08820293 0,11605649 ! vesicle targeting GO:0006903 32 23 0,000 0,08820293 0,11599014 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,08820293 0,11592386 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,08820293 0,11585765 ! osteoblast differentiation GO:0001649 40 23 0,000 0,08820293 0,11579152 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,08820293 0,11572547 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,08820293 0,11565949 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,08820293 0,11559359 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,08820293 0,11552776 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,08820293 0,11546201 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,08820293 0,11539633 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,08820293 0,11533073 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,08820293 0,1152652 ! cell fate determination GO:0001709 45 23 0,000 0,08820293 0,11519974 ! pentose metabolic process GO:0019321 31 23 0,000 0,08820293 0,11513436 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,08820293 0,11506906 ! spermatid development GO:0007286 33 23 0,000 0,08820293 0,11500383 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,08820293 0,11493867 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,08820293 0,11487358 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,08820293 0,11480857 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,08820293 0,11474364 ! telomere organization GO:0032200 32 23 0,000 0,08820293 0,11467877 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,08820293 0,11461398 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,08820293 0,11454927 ! regulation of amine transport GO:0051952 38 23 0,000 0,08820293 0,11448462 ! liver development GO:0001889 40 23 0,000 0,08820293 0,11442005 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,09185869 0,11909525 ! initiation of viral infection GO:0019059 42 24 0,000 0,09185869 0,11902816 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,09185869 0,11896114 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,09185869 0,11889419 ! superoxide metabolic process GO:0006801 32 24 0,000 0,09185869 0,11882732 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,09185869 0,11876053 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,09185869 0,11869381 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,09185869 0,11862717 ! sperm motility GO:0030317 27 24 0,000 0,09185869 0,1185606 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,09185869 0,1184941 ! vacuole organization GO:0007033 39 24 0,000 0,09185869 0,11842768 ! receptor metabolic process GO:0043112 37 24 0,000 0,09185869 0,11836133 ! neural crest cell development GO:0014032 39 24 0,000 0,09185869 0,11829506 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,09185869 0,11822886 ! primary neural tube formation GO:0014020 35 24 0,000 0,09185869 0,11816274 ! negative regulation of cell development GO:0010721 56 24 0,000 0,09185869 0,11809669 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,09185869 0,11803072 ! base-excision repair GO:0006284 31 24 0,000 0,09185869 0,11796481 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,09185869 0,11789899 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,09185869 0,11783323 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,09185869 0,11776755 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,09185869 0,11770194 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,09549999 0,12229954 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,09549999 0,12223149 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,09549999 0,1221635 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,09549999 0,1220956 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,09549999 0,12202777 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,09549999 0,12196001 ! peptide transport GO:0015833 43 25 0,000 0,09549999 0,12189233 ! male gonad development GO:0008584 33 25 0,000 0,09549999 0,12182473 ! iron ion homeostasis GO:0055072 39 25 0,000 0,09549999 0,1217572 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,09549999 0,12168974 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,09549999 0,12162236 ! phospholipid transport GO:0015914 35 25 0,000 0,09549999 0,12155505 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,09549999 0,12148782 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,09549999 0,12142066 ! detection of light stimulus GO:0009583 30 25 0,000 0,09549999 0,12135358 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,09549999 0,12128657 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,09549999 0,12121964 ! leukocyte proliferation GO:0070661 39 25 0,000 0,09549999 0,12115278 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,09549999 0,12108599 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,0991269 0,12561536 ! translational initiation GO:0006413 43 26 0,000 0,0991269 0,12554619 ! regulation of pH GO:0006885 36 26 0,000 0,0991269 0,12547709 ! circadian rhythm GO:0007623 42 26 0,000 0,0991269 0,12540807 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,0991269 0,12533913 ! post-embryonic development GO:0009791 42 26 0,000 0,0991269 0,12527026 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,0991269 0,12520147 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,0991269 0,12513275 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,0991269 0,12506411 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,0991269 0,12499555 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,0991269 0,12492706 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,0991269 0,12485864 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,10273948 0,12933815 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,10273948 0,1292674 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,10273948 0,12919672 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,10273948 0,12912612 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,10273948 0,1290556 ! catechol metabolic process GO:0009712 43 27 0,000 0,10273948 0,12898515 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,10273948 0,12891479 ! acute-phase response GO:0006953 42 27 0,000 0,10273948 0,12884449 ! myofibril assembly GO:0030239 36 27 0,000 0,10273948 0,12877428 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,10273948 0,12870414 ! response to ionizing radiation GO:0010212 47 27 0,000 0,10273948 0,12863408 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,10273948 0,12856409 ! natural killer cell activation GO:0030101 35 27 0,000 0,10273948 0,12849418 ! lipid oxidation GO:0034440 38 27 0,000 0,10273948 0,12842435 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,10273948 0,12835459 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,10273948 0,12828491 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,10273948 0,1282153 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,10273948 0,12814577 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,10273948 0,12807632 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,10273948 0,12800694 ! gene silencing GO:0016458 41 27 0,000 0,10273948 0,12793763 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,10633777 0,1323468 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,10633777 0,13227522 ! phenol metabolic process GO:0018958 44 28 0,000 0,10633777 0,13220372 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,10633777 0,1321323 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,10633777 0,13206095 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,10633777 0,13198968 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,10633777 0,13191849 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,10633777 0,13184737 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,10633777 0,13177634 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,10633777 0,13170537 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,10633777 0,13163449 ! mesoderm formation GO:0001707 46 28 0,000 0,10633777 0,13156368 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,10633777 0,13149295 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,10633777 0,13142229 ! ensheathment of neurons GO:0007272 43 28 0,000 0,10633777 0,13135171 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,10633777 0,1312812 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,10633777 0,13121077 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,10633777 0,13114042 ! neural tube formation GO:0001841 41 28 0,000 0,10633777 0,13107014 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,10633777 0,13099994 ! placenta development GO:0001890 37 28 0,000 0,10633777 0,13092981 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,10992184 0,13527033 ! regulation of innate immune response GO:0045088 38 29 0,000 0,10992184 0,13519799 ! ovulation cycle process GO:0022602 41 29 0,000 0,10992184 0,13512573 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,10992184 0,13505355 ! protein targeting to membrane GO:0006612 53 29 0,000 0,10992184 0,13498144 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,10992184 0,13490941 ! mismatch repair GO:0006298 34 29 0,000 0,10992184 0,13483746 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,10992184 0,13476559 ! muscle cell development GO:0055001 38 29 0,000 0,10992184 0,13469379 ! formation of primary germ layer GO:0001704 48 29 0,000 0,10992184 0,13462207 ! telencephalon development GO:0021537 52 29 0,000 0,10992184 0,13455042 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,10992184 0,13447885 ! eye morphogenesis GO:0048592 51 29 0,000 0,10992184 0,13440736 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,10992184 0,13433594 ! tissue homeostasis GO:0001894 42 29 0,000 0,10992184 0,1342646 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,11349174 0,13855149 ! collagen metabolic process GO:0032963 40 30 0,000 0,11349174 0,13847799 ! organic anion transport GO:0015711 51 30 0,000 0,11349174 0,13840457 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,11349174 0,13833122 ! spliceosome assembly GO:0000245 49 30 0,000 0,11349174 0,13825795 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,11349174 0,13818476 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,11349174 0,13811165 ! ceramide metabolic process GO:0006672 43 30 0,000 0,11349174 0,13803861 ! ovulation cycle GO:0042698 43 30 0,000 0,11349174 0,13796565 ! hindbrain development GO:0030902 45 30 0,000 0,11349174 0,13789277 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,11349174 0,13781996 ! adult locomotory behavior GO:0008344 47 30 0,000 0,11349174 0,13774724 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,11349174 0,13767458 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,11349174 0,13760201 ! response to heat GO:0009408 41 30 0,000 0,11349174 0,13752951 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,11349174 0,13745709 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,11349174 0,13738474 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,11704753 0,14161458 ! negative regulation of secretion GO:0051048 49 31 0,000 0,11704753 0,14154013 ! glial cell differentiation GO:0010001 55 31 0,000 0,11704753 0,14146575 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,11704753 0,14139145 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,11704753 0,14131723 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,11704753 0,14124308 ! odontogenesis GO:0042476 50 31 0,000 0,11704753 0,14116902 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,11704753 0,14109503 ! segmentation GO:0035282 41 31 0,000 0,11704753 0,14102112 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,11704753 0,14094729 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,11704753 0,14087353 ! metanephros development GO:0001656 58 31 0,000 0,11704753 0,14079985 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,11704753 0,14072625 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,11704753 0,14065273 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,11704753 0,14057928 ! cell fate specification GO:0001708 37 31 0,000 0,11704753 0,14050591 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,11704753 0,14043261 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,11704753 0,1403594 ! RNA modification GO:0009451 40 31 0,000 0,11704753 0,14028625 ! regulation of muscle development GO:0048634 48 32 0,000 0,12058926 0,14445588 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,12058926 0,14438068 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,12058926 0,14430556 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,12058926 0,14423052 ! meiosis I GO:0007127 52 32 0,000 0,12058926 0,14415556 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,12058926 0,14408067 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,12058926 0,14400586 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,12058926 0,14393113 ! peripheral nervous system development GO:0007422 53 32 0,000 0,12058926 0,14385648 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,12058926 0,1437819 ! cytokine production GO:0001816 44 32 0,000 0,12058926 0,1437074 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,12058926 0,14363298 ! vesicle localization GO:0051648 47 32 0,000 0,12058926 0,14355864 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,12411698 0,14768187 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,12411698 0,14760551 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,12411698 0,14752923 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,12411698 0,14745302 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,12411698 0,1473769 ! sister chromatid segregation GO:0000819 46 33 0,000 0,12411698 0,14730085 ! ear morphogenesis GO:0042471 42 33 0,000 0,12411698 0,14722489 ! actomyosin structure organization GO:0031032 43 33 0,000 0,12411698 0,147149 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,12411698 0,14707319 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,12411698 0,14699745 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,12411698 0,1469218 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,12411698 0,14684622 ! female gonad development GO:0008585 49 33 0,000 0,12411698 0,14677072 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,12411698 0,1466953 ! positive regulation of cell development GO:0010720 54 33 0,000 0,12411698 0,14661996 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,12411698 0,14654469 ! regulation of proteolysis GO:0030162 50 33 0,000 0,12411698 0,1464695 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,12411698 0,14639439 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,12411698 0,14631935 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,12411698 0,14624439 ! cytokinesis GO:0000910 52 33 0,000 0,12411698 0,14616951 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,12411698 0,1460947 ! mRNA catabolic process GO:0006402 48 34 0,000 0,12763075 0,15015383 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,12763075 0,15007706 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,12763075 0,15000037 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,12763075 0,14992376 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,12763075 0,14984723 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,12763075 0,14977078 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,12763075 0,14969441 ! female gamete generation GO:0007292 43 34 0,000 0,12763075 0,14961811 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,12763075 0,14954189 ! polyol metabolic process GO:0019751 44 34 0,000 0,12763075 0,14946575 ! aerobic respiration GO:0009060 47 34 0,000 0,12763075 0,14938968 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,12763075 0,1493137 ! embryonic organ development GO:0048568 45 34 0,000 0,12763075 0,14923779 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,12763075 0,14916196 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,13113063 0,15317443 ! Notch signaling pathway GO:0007219 56 35 0,000 0,13113063 0,15309667 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,13113063 0,153019 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,13113063 0,1529414 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,13113063 0,15286388 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,13113063 0,15278645 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,13113063 0,15270909 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,13113063 0,1526318 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,13113063 0,1525546 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,13113063 0,15247747 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,13113063 0,15240043 ! glycogen metabolic process GO:0005977 48 35 0,000 0,13113063 0,15232346 ! pigment metabolic process GO:0042440 61 35 0,000 0,13113063 0,15224656 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,13461666 0,1562151 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,13461666 0,15613632 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,13461666 0,15605762 ! negative regulation of binding GO:0051100 58 36 0,000 0,13461666 0,15597901 ! neural tube development GO:0021915 50 36 0,000 0,13461666 0,15590047 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,13461666 0,15582201 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,13461666 0,15574362 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,13461666 0,15566532 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,13461666 0,1555871 ! glucan metabolic process GO:0044042 49 36 0,000 0,13461666 0,15550895 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,13808891 0,15944001 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,13808891 0,15936001 ! learning GO:0007612 67 37 0,000 0,13808891 0,15928009 ! ion transmembrane transport GO:0034220 56 37 0,000 0,13808891 0,15920025 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,13808891 0,15912049 ! regulation of protein secretion GO:0050708 51 37 0,000 0,13808891 0,15904081 ! amino acid activation GO:0043038 52 37 0,000 0,13808891 0,15896121 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,13808891 0,15888169 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,14154743 0,16277954 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,14154743 0,16269819 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,14154743 0,16261692 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,14154743 0,16253574 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,14154743 0,16245463 ! phagocytosis GO:0006909 60 38 0,000 0,14154743 0,1623736 ! mesenchymal cell development GO:0014031 64 38 0,000 0,14154743 0,16229266 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,14154743 0,1622118 ! maintenance of location in cell GO:0051651 69 38 0,000 0,14154743 0,16213101 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,14499226 0,16599412 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,14499226 0,16591154 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,14499226 0,16582904 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,14499226 0,16574662 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,14499226 0,16566428 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,14499226 0,16558202 ! male sex differentiation GO:0046661 53 39 0,000 0,14499226 0,16549985 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,14499226 0,16541776 ! chromatin remodeling GO:0006338 68 39 0,000 0,14499226 0,16533574 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,14499226 0,16525381 ! JNK cascade GO:0007254 54 39 0,000 0,14499226 0,16517196 ! developmental growth GO:0048589 62 39 0,000 0,14499226 0,1650902 ! cell growth GO:0016049 61 39 0,000 0,14499226 0,16500851 ! synapse organization GO:0050808 55 39 0,000 0,14499226 0,1649269 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,14842347 0,1687464 ! response to calcium ion GO:0051592 58 40 0,000 0,14842347 0,16866303 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,14842347 0,16857974 ! regulation of tube size GO:0035150 60 40 0,000 0,14842347 0,16849653 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,14842347 0,1684134 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,14842347 0,16833036 ! peptide metabolic process GO:0006518 56 40 0,000 0,14842347 0,1682474 ! inner ear development GO:0048839 57 40 0,000 0,14842347 0,16816452 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,14842347 0,16808172 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,14842347 0,167999 ! B cell differentiation GO:0030183 62 40 0,000 0,14842347 0,16791637 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,14842347 0,16783381 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,14842347 0,16775134 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,14842347 0,16766894 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,1518411 0,17144552 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,1518411 0,1713614 ! glucose transport GO:0015758 52 41 0,000 0,1518411 0,17127736 ! endosome transport GO:0016197 71 41 0,000 0,1518411 0,1711934 ! striated muscle contraction GO:0006941 62 41 0,000 0,1518411 0,17110952 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,1518411 0,17102572 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,1518411 0,17094201 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,1518411 0,17085838 ! biopolymer methylation GO:0043414 62 41 0,000 0,1518411 0,17077483 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,1518411 0,17069136 ! mitochondrial transport GO:0006839 60 42 0,000 0,15524521 0,17443282 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,15524521 0,17434765 ! cellular component disassembly GO:0022411 64 42 0,000 0,15524521 0,17426256 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,15524521 0,17417755 ! hexose transport GO:0008645 54 42 0,000 0,15524521 0,17409263 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,15524521 0,17400779 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,15524521 0,17392303 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,15524521 0,17383836 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,15524521 0,17375376 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,15524521 0,17366925 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,15524521 0,17358483 ! positive regulation of binding GO:0051099 59 43 0,000 0,15863586 0,17728983 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,15863586 0,17720372 ! leukocyte migration GO:0050900 60 43 0,000 0,15863586 0,1771177 ! neuromuscular process GO:0050905 79 43 0,000 0,15863586 0,17703176 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,15863586 0,17694591 ! tRNA processing GO:0008033 49 43 0,000 0,15863586 0,17686014 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,15863586 0,17677445 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,15863586 0,17668885 ! methylation GO:0032259 64 43 0,000 0,15863586 0,17660332 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,16201308 0,18027581 ! glycolysis GO:0006096 53 44 0,000 0,16201308 0,18018863 ! regulation of action potential GO:0001508 71 44 0,000 0,16201308 0,18010154 ! regulation of ion transport GO:0043269 57 44 0,000 0,16201308 0,18001454 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,16201308 0,17992762 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,16201308 0,17984078 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,16201308 0,17975402 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,16201308 0,17966735 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,16201308 0,17958077 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,16201308 0,17949426 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,16201308 0,17940784 ! RNA catabolic process GO:0006401 64 45 0,000 0,16537695 0,18304475 ! positive regulation of defense response GO:0031349 59 45 0,000 0,16537695 0,1829567 ! regulation of translational initiation GO:0006446 64 45 0,000 0,16537695 0,18286874 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,16537695 0,18278087 ! cell recognition GO:0008037 58 45 0,000 0,16537695 0,18269308 ! cell maturation GO:0048469 60 45 0,000 0,16537695 0,18260537 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,1687275 0,18621557 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,1687275 0,18612626 ! cell redox homeostasis GO:0045454 63 46 0,000 0,1687275 0,18603704 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,1687275 0,1859479 ! histone modification GO:0016570 68 46 0,000 0,1687275 0,18585884 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,1687275 0,18576987 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,1720648 0,18935361 ! viral infectious cycle GO:0019058 71 47 0,000 0,1720648 0,18926305 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,1720648 0,18917258 ! covalent chromatin modification GO:0016569 75 47 0,000 0,1720648 0,1890822 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,1720648 0,1889919 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,1720648 0,18890169 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,1720648 0,18881156 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,1720648 0,18872152 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,1720648 0,18863157 ! chloride transport GO:0006821 67 48 0,000 0,17538889 0,19218411 ! response to temperature stimulus GO:0009266 62 48 0,000 0,17538889 0,19209259 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,17538889 0,19200116 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,17538889 0,19190982 ! gastrulation GO:0007369 73 48 0,000 0,17538889 0,19181856 ! heart morphogenesis GO:0003007 65 48 0,000 0,17538889 0,19172739 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,17538889 0,19163631 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,17538889 0,19154532 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,17538889 0,19145441 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,17538889 0,19136359 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,17869982 0,19488363 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,17869982 0,19479127 ! sensory perception of smell GO:0007608 61 49 0,000 0,17869982 0,194699 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,17869982 0,19460681 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,17869982 0,19451471 ! RNA elongation GO:0006354 62 49 0,000 0,17869982 0,1944227 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,17869982 0,19433077 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,17869982 0,19423893 ! germ cell development GO:0007281 68 49 0,000 0,17869982 0,19414718 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,17869982 0,19405551 ! regulation of actin filament length GO:0030832 72 50 0,000 0,18199764 0,19754346 ! ear development GO:0043583 72 50 0,000 0,18199764 0,19745027 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,18199764 0,19735718 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,18199764 0,19726418 ! positive regulation of growth GO:0045927 67 50 0,000 0,18199764 0,19717126 ! proton transport GO:0015992 75 50 0,000 0,18199764 0,19707843 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,18199764 0,19698569 ! positive regulation of secretion GO:0051047 71 51 0,000 0,18528242 0,20044664 ! hydrogen transport GO:0006818 77 51 0,000 0,18528242 0,2003524 ! muscle fiber development GO:0048747 74 51 0,000 0,18528242 0,20025825 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,18528242 0,20016419 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,18528242 0,20007022 ! transition metal ion transport GO:0000041 74 52 0,000 0,18855419 0,20350757 ! regulation of cellular component size GO:0032535 74 52 0,000 0,18855419 0,20341212 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,18855419 0,20331675 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,18855419 0,20322148 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,19181301 0,20663696 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,19181301 0,20654022 ! kidney development GO:0001822 90 53 0,000 0,19181301 0,20644357 ! single fertilization GO:0007338 59 53 0,000 0,19181301 0,20634701 ! amino acid transport GO:0006865 84 54 0,000 0,19505892 0,20974078 ! regulation of mitosis GO:0007088 84 54 0,000 0,19505892 0,20964277 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,19505892 0,20954485 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,19505892 0,20944702 ! DNA catabolic process GO:0006308 67 54 0,000 0,19505892 0,20934929 ! detection of external stimulus GO:0009581 66 54 0,000 0,19505892 0,20925164 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,19505892 0,20915409 ! exocytosis GO:0006887 74 55 0,000 0,19829199 0,2125217 ! mesoderm development GO:0007498 76 55 0,000 0,19829199 0,21242272 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,19829199 0,21232382 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,19829199 0,21222502 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,20151225 0,21557125 ! carbohydrate transport GO:0008643 74 57 0,000 0,20471977 0,21890073 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,20471977 0,21879901 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,20471977 0,21869738 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,20471977 0,21859585 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,20471977 0,21849442 ! camera-type eye development GO:0043010 88 57 0,000 0,20471977 0,21839307 ! secondary metabolic process GO:0019748 84 57 0,000 0,20471977 0,21829183 ! developmental maturation GO:0021700 75 57 0,000 0,20471977 0,21819067 ! gonad development GO:0008406 79 57 0,000 0,20471977 0,21808961 ! viral reproductive process GO:0022415 87 58 0,000 0,20791458 0,22139053 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,20791458 0,22128808 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,21109674 0,224571 ! activation of MAPK activity GO:0000187 84 59 0,000 0,21109674 0,22446718 ! actin filament organization GO:0007015 95 59 0,000 0,21109674 0,22436345 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,21109674 0,22425982 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,2142663 0,22752193 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,2142663 0,22741693 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,2142663 0,22731204 ! regulation of heart contraction GO:0008016 91 60 0,000 0,2142663 0,22720724 ! fertilization GO:0009566 68 60 0,000 0,2142663 0,22710253 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,21742331 0,23034252 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,21742331 0,23023647 ! urogenital system development GO:0001655 101 61 0,000 0,21742331 0,23013051 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,21742331 0,23002466 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,21742331 0,2299189 ! extracellular matrix organization GO:0030198 103 61 0,000 0,21742331 0,22981324 ! amine catabolic process GO:0009310 90 62 0,000 0,22056781 0,23302984 ! neurotransmitter transport GO:0006836 81 62 0,000 0,22056781 0,23292285 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,22056781 0,23281595 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,22369986 0,23601361 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,22369986 0,2359054 ! viral reproduction GO:0016032 92 63 0,000 0,22369986 0,23579728 ! appendage morphogenesis GO:0035107 93 64 0,000 0,2268195 0,23897611 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,2268195 0,23886669 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,2268195 0,23875737 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,2268195 0,23864814 ! hexose catabolic process GO:0019320 82 64 0,000 0,2268195 0,23853902 ! reproductive structure development GO:0048608 90 65 0,000 0,22992678 0,24169634 ! appendage development GO:0048736 94 65 0,000 0,22992678 0,24158593 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,22992678 0,24147561 ! defense response to bacterium GO:0042742 73 65 0,000 0,22992678 0,2413654 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,22992678 0,24125529 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,23302175 0,24439126 ! axon guidance GO:0007411 99 66 0,000 0,23302175 0,24427987 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,23302175 0,24416858 ! regulation of immune effector process GO:0002697 101 66 0,000 0,23302175 0,24405739 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,23610446 0,24717354 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,23917496 0,25027407 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,23917496 0,25016025 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,23917496 0,25004655 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,23917496 0,24993294 ! rhythmic process GO:0048511 105 68 0,000 0,23917496 0,24981944 ! inorganic anion transport GO:0015698 93 68 0,000 0,23917496 0,24970604 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,24223329 0,25278428 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,24223329 0,25266964 ! response to drug GO:0042493 108 69 0,000 0,24223329 0,2525551 ! response to metal ion GO:0010038 103 70 0,000 0,2452795 0,25561524 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,2452795 0,25549948 ! eye development GO:0001654 111 70 0,000 0,2452795 0,25538381 ! amine transport GO:0015837 101 70 0,000 0,2452795 0,25526825 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,2452795 0,2551528 ! regulation of catabolic process GO:0009894 106 70 0,000 0,2452795 0,25503745 ! muscle cell differentiation GO:0042692 104 71 0,000 0,24831364 0,25807563 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,24831364 0,25795906 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,24831364 0,2578426 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,24831364 0,25772625 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,25133575 0,26074525 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,25133575 0,2606277 ! negative regulation of transport GO:0051051 116 73 0,000 0,25434589 0,26363026 ! regulation of blood pressure GO:0008217 107 73 0,000 0,25434589 0,26351151 ! tube morphogenesis GO:0035239 118 73 0,000 0,25434589 0,26339286 ! mitochondrion organization GO:0007005 104 73 0,000 0,25434589 0,26327432 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,25434589 0,26315589 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,25434589 0,26303757 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,2573441 0,26601862 ! digestion GO:0007586 97 74 0,000 0,2573441 0,26589911 ! protein import into nucleus GO:0006606 118 74 0,000 0,2573441 0,26577971 ! response to inorganic substance GO:0010035 115 75 0,000 0,26033042 0,26874325 ! response to nutrient GO:0007584 104 75 0,000 0,26033042 0,26862269 ! nuclear import GO:0051170 121 75 0,000 0,26033042 0,26850223 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,26033042 0,26838188 ! amine biosynthetic process GO:0009309 97 76 0,000 0,26330491 0,27132674 ! tRNA metabolic process GO:0006399 95 76 0,000 0,26330491 0,27120523 ! response to unfolded protein GO:0006986 99 76 0,000 0,26330491 0,27108383 ! regulation of protein transport GO:0051223 114 76 0,000 0,26330491 0,27096254 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,2662676 0,27388885 ! regulation of DNA binding GO:0051101 119 77 0,000 0,2662676 0,27376642 ! sex differentiation GO:0007548 105 77 0,000 0,2662676 0,27364409 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,2662676 0,27352188 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,2662676 0,27339977 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,2662676 0,27327777 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,26921855 0,27618317 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,26921855 0,27606004 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,26921855 0,27593701 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,2721578 0,27882536 ! cellular respiration GO:0045333 107 79 0,000 0,2721578 0,27870122 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,2721578 0,27857719 ! T cell activation GO:0042110 134 79 0,000 0,2721578 0,27845326 ! regulation of lyase activity GO:0051339 133 79 0,000 0,2721578 0,27832945 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,2721578 0,27820575 ! alcohol catabolic process GO:0046164 104 80 0,000 0,27508539 0,28107348 ! protein localization in nucleus GO:0034504 133 80 0,000 0,27508539 0,28094867 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,27508539 0,28082397 ! forebrain development GO:0030900 131 80 0,000 0,27508539 0,28069938 ! mRNA transport GO:0051028 121 81 0,000 0,27800138 0,28354908 ! response to protein stimulus GO:0051789 111 81 0,000 0,27800138 0,28342339 ! regulation of neurological system process GO:0031644 122 81 0,000 0,27800138 0,28329782 ! vitamin metabolic process GO:0006766 103 81 0,000 0,27800138 0,28317236 ! detection of stimulus GO:0051606 108 82 0,000 0,28090581 0,28600414 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,28379872 0,2888217 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,28379872 0,28869396 ! regulation of defense response GO:0031347 117 84 0,000 0,28668015 0,29149617 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,28955016 0,2942843 ! rRNA metabolic process GO:0016072 107 85 0,000 0,28955016 0,29415431 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,28955016 0,29402444 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,28955016 0,29389469 ! regulation of protein localization GO:0032880 132 85 0,000 0,28955016 0,29376505 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,29525607 0,29942194 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,29525607 0,29928998 ! female pregnancy GO:0007565 130 87 0,000 0,29525607 0,29915813 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,29525607 0,2990264 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,29809206 0,30176573 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,29809206 0,30163297 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,29809206 0,30150032 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,29809206 0,3013678 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! reproductive developmental process GO:0003006 127 89 0,000 0,3009168 0,30408991 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,3009168 0,30395636 ! regulation of T cell activation GO:0050863 128 89 0,000 0,3009168 0,30382293 ! RNA localization GO:0006403 135 91 0,000 0,30653271 0,30935728 ! ATP metabolic process GO:0046034 137 91 0,000 0,30653271 0,30922159 ! response to virus GO:0009615 122 91 0,000 0,30653271 0,30908603 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,30932396 0,31176386 ! cell fate commitment GO:0045165 141 92 0,000 0,30932396 0,3116273 ! sulfur metabolic process GO:0006790 118 92 0,000 0,30932396 0,31149086 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,31210414 0,31415297 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,31210414 0,31401554 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,31210414 0,31387824 ! electron transport chain GO:0022900 123 94 0,000 0,31487329 0,31652473 ! regulation of binding GO:0051098 151 95 0,000 0,31763145 0,31915786 ! carboxylic acid transport GO:0046942 147 95 0,000 0,31763145 0,31901849 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,32037866 0,32163724 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,32311497 0,32424278 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,32311497 0,32410137 ! extracellular structure organization GO:0043062 156 99 0,000 0,32855506 0,3294144 ! protein import GO:0017038 156 99 0,000 0,32855506 0,32927086 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,33125891 0,33183602 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,33125891 0,33169156 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,33125891 0,33154722 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,33125891 0,331403 ! protein localization in organelle GO:0033365 161 100 0,000 0,33125891 0,33125891