pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/578-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! tube morphogenesis GO:0035239 118 73 6,000 8,89E-07 2,045E-03 ! nuclear migration GO:0007097 10 5 2,000 3,532E-06 4,061E-03 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 3,532E-06 2,708E-03 GO:0031272|regulation of pseudopodium assembly, ! glial cell migration GO:0008347 10 5 2,000 3,532E-06 2,031E-03 ! mitotic cell cycle checkpoint GO:0007093 63 34 4,000 4,064E-06 1,87E-03 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 5,000 4,324E-06 1,658E-03 ! negative regulation of ligase activity GO:0051352 91 61 5,000 4,768E-06 1,567E-03 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 5,000 4,768E-06 1,371E-03 ! angiogenesis GO:0001525 149 95 6,000 5,295E-06 1,353E-03 ! cell cycle checkpoint GO:0000075 108 64 5,000 6,327E-06 1,455E-03 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 5,000 6,929E-06 1,449E-03 ! macrophage differentiation GO:0030225 10 6 2,000 7,026E-06 1,347E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 5,000 1,16E-05 2,053E-03 ! branching morphogenesis of a tube GO:0048754 72 42 4,000 1,187E-05 1,95E-03 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 1,223E-05 1,876E-03 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 1,223E-05 1,758E-03 ! establishment of nucleus localization GO:0040023 13 7 2,000 1,223E-05 1,655E-03 ! response to hypoxia GO:0001666 132 72 5,000 1,258E-05 1,608E-03 ! epithelial tube morphogenesis GO:0060562 65 43 4,000 1,335E-05 1,617E-03 ! response to oxygen levels GO:0070482 137 74 5,000 1,475E-05 1,696E-03 ! regulation of ligase activity GO:0051340 114 75 5,000 1,594E-05 1,745E-03 ! ureteric bud development GO:0001657 32 22 3,000 1,649E-05 1,724E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 1,947E-05 1,947E-03 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 4,000 2,08E-05 1,993E-03 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 5,000 2,31E-05 2,125E-03 GO:0010498|proteasomal protein catabolic process, ! RNA elongation GO:0006354 62 49 4,000 2,556E-05 2,261E-03 ! morphogenesis of a branching structure GO:0001763 86 49 4,000 2,556E-05 2,178E-03 ! positive regulation of GTPase activity GO:0043547 21 9 2,000 2,905E-05 2,386E-03 ! SMAD protein nuclear translocation GO:0007184 15 9 2,000 2,905E-05 2,304E-03 ! nucleus localization GO:0051647 15 9 2,000 2,905E-05 2,227E-03 ! regulation of phosphatase activity GO:0010921 21 10 2,000 4,128E-05 3,063E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 4,128E-05 2,967E-03 ! positive regulation of leukocyte migration GO:0002687 23 10 2,000 4,128E-05 2,877E-03 ! detection of bacterium GO:0016045 10 10 2,000 4,128E-05 2,793E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 3,000 4,465E-05 2,934E-03 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 2,000 5,647E-05 3,608E-03 ! filopodium assembly GO:0046847 19 11 2,000 5,647E-05 3,51E-03 ! negative regulation of proteolysis GO:0045861 16 11 2,000 5,647E-05 3,418E-03 ! adult heart development GO:0007512 11 11 2,000 5,647E-05 3,33E-03 ! regulation of leukocyte migration GO:0002685 24 11 2,000 5,647E-05 3,247E-03 ! spindle organization GO:0007051 37 30 3,000 5,911E-05 3,316E-03 ! lung development GO:0030324 94 59 4,000 6,339E-05 3,472E-03 ! regulation of cellular component biogenesis GO:0044087 158 96 5,000 6,494E-05 3,473E-03 ! metanephros development GO:0001656 58 31 3,000 6,749E-05 3,528E-03 ! urogenital system development GO:0001655 101 61 4,000 7,448E-05 3,807E-03 ! positive regulation of cell growth GO:0030307 16 12 2,000 7,49E-05 3,745E-03 ! microspike assembly GO:0030035 23 12 2,000 7,49E-05 3,665E-03 ! mitotic sister chromatid segregation GO:0000070 45 32 3,000 7,671E-05 3,676E-03 ! respiratory tube development GO:0030323 99 62 4,000 8,055E-05 3,781E-03 ! sister chromatid segregation GO:0000819 46 33 3,000 8,681E-05 3,993E-03 ! respiratory system development GO:0060541 100 64 4,000 9,384E-05 4,232E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 1,226E-04 5,424E-03 GO:0060675|ureteric bud morphogenesis, ! epithelial to mesenchymal transition GO:0001837 22 14 2,000 1,226E-04 5,322E-03 ! acute inflammatory response GO:0002526 92 68 4,000 1,254E-04 5,341E-03 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 4,000 1,439E-04 6,02E-03 ! mesenchymal cell development GO:0014031 64 38 3,000 1,523E-04 6,256E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! positive regulation of cell size GO:0045793 20 15 2,000 1,525E-04 6,153E-03 ! phosphoinositide-mediated signaling GO:0048015 109 71 4,000 1,54E-04 6,106E-03 ! complement activation, alternative pathway GO:0006957 16 16 2,000 1,867E-04 7,278E-03 ! regulation of dephosphorylation GO:0035303 33 16 2,000 1,867E-04 7,157E-03 ! detection of biotic stimulus GO:0009595 19 16 2,000 1,867E-04 7,04E-03 ! negative regulation of protein catabolic process GO:0042177 26 17 2,000 2,255E-04 8,366E-03 ! positive regulation of ossification GO:0045778 30 19 2,000 3,18E-04 0,01161081 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 2,000 3,18E-04 0,01142939 ! transcription initiation GO:0006352 118 85 4,000 3,582E-04 0,01267581 ! positive regulation of locomotion GO:0040017 35 20 2,000 3,722E-04 0,01297095 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! heart morphogenesis GO:0003007 65 48 3,000 3,8E-04 0,01304482 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 4,32E-04 0,01461121 ! positive regulation of bone remodeling GO:0046852 33 21 2,000 4,32E-04 0,01439946 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 2,000 4,32E-04 0,01419375 ! regulation of chemotaxis GO:0050920 36 21 2,000 4,32E-04 0,01399384 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 4,8E-04 0,01533469 ! positive regulation of cell migration GO:0030335 92 51 3,000 4,8E-04 0,01512463 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 4,976E-04 0,01546557 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 4,976E-04 0,01525936 GO:0010810|regulation of cell-substrate adhesion, ! regulation of behavior GO:0050795 38 22 2,000 4,976E-04 0,01505858 ! negative regulation of protein ubiquitination GO:0031397 7 5 1,000 5,001E-04 0,01493786 ! negative regulation of bone resorption GO:0045779 10 5 1,000 5,001E-04 0,01474635 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 5,001E-04 0,01455969 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 1,000 5,001E-04 0,01437769 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 1,000 5,001E-04 0,01420019 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! neutrophil mediated immunity GO:0002446 6 5 1,000 5,001E-04 0,01402702 ! microvillus organization GO:0032528 7 5 1,000 5,001E-04 0,01385802 GO:0030033|microvillus assembly, ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 1,000 5,001E-04 0,01369304 ! positive regulation of Rho GTPase activity GO:0032321 9 5 1,000 5,001E-04 0,01353195 ! positive regulation of chemokine production GO:0032722 7 5 1,000 5,001E-04 0,0133746 ! enteric nervous system development GO:0048484 8 5 1,000 5,001E-04 0,01322087 ! muscle cell proliferation GO:0033002 8 5 1,000 5,001E-04 0,01307063 ! regulation of hair follicle development GO:0051797 9 5 1,000 5,001E-04 0,01292377 GO:0042634|regulation of hair cycle, ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 5,001E-04 0,01278017 ! regulation of sensory perception GO:0051931 6 5 1,000 5,001E-04 0,01263973 GO:0051930|regulation of sensory perception of pain, ! nucleotide-excision repair GO:0006289 64 52 3,000 5,172E-04 0,0129298 ! regulation of bone remodeling GO:0046850 90 53 3,000 5,563E-04 0,013759 ! kidney development GO:0001822 90 53 3,000 5,563E-04 0,01361262 ! cell projection assembly GO:0030031 76 53 3,000 5,563E-04 0,01346933 ! positive regulation of cell adhesion GO:0045785 37 23 2,000 5,692E-04 0,01363823 ! negative regulation of catabolic process GO:0009895 34 23 2,000 5,692E-04 0,01349763 ! regulation of protein complex assembly GO:0043254 81 54 3,000 5,976E-04 0,0140242 ! regulation of mitosis GO:0007088 84 54 3,000 5,976E-04 0,01388255 GO:0051783|regulation of nuclear division, ! regulation of tissue remodeling GO:0034103 91 54 3,000 5,976E-04 0,01374372 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 6,472E-04 0,01473787 ! positive regulation of cell motion GO:0051272 99 56 3,000 6,864E-04 0,01547763 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 7,214E-04 0,01610998 ! chromosome segregation GO:0007059 83 57 3,000 7,342E-04 0,01623613 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 7,466E-04 0,01635469 ! mRNA stabilization GO:0048255 15 6 1,000 7,466E-04 0,0162004 GO:0043489|RNA stabilization, ! erythrocyte maturation GO:0043249 6 6 1,000 7,466E-04 0,016049 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 7,466E-04 0,0159004 ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 7,466E-04 0,01575452 ! spindle checkpoint GO:0031577 14 6 1,000 7,466E-04 0,0156113 ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 7,466E-04 0,01547066 ! interaction with symbiont GO:0051702 8 6 1,000 7,466E-04 0,01533253 ! negative regulation of focal adhesion formation GO:0051895 16 6 1,000 7,466E-04 0,01519684 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 7,466E-04 0,01506353 ! salivary gland morphogenesis GO:0007435 11 6 1,000 7,466E-04 0,01493255 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 7,466E-04 0,01480382 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 8,227E-04 0,01617352 ! myeloid cell differentiation GO:0030099 85 59 3,000 8,366E-04 0,01630735 ! acute-phase response GO:0006953 42 27 2,000 9,208E-04 0,01779643 ! organelle localization GO:0051640 96 62 3,000 1,009E-03 0,01933343 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,04E-03 0,01977592 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,04E-03 0,01961383 ! retinol metabolic process GO:0042572 9 7 1,000 1,04E-03 0,01945436 ! transcription from RNA polymerase I promoter GO:0006360 12 7 1,000 1,04E-03 0,01929747 ! positive regulation of epidermis development GO:0045684 11 7 1,000 1,04E-03 0,01914309 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 1,000 1,04E-03 0,01899116 GO:0002688|regulation of leukocyte chemotaxis, ! dopamine biosynthetic process GO:0042416 15 7 1,000 1,04E-03 0,01884163 ! embryonic epithelial tube formation GO:0001838 44 30 2,000 1,258E-03 0,02260919 ! induction of positive chemotaxis GO:0050930 14 8 1,000 1,381E-03 0,02461697 ! pseudouridine synthesis GO:0001522 9 8 1,000 1,381E-03 0,02442761 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,381E-03 0,02424114 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,381E-03 0,0240575 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,381E-03 0,02387661 GO:0045685|regulation of glial cell differentiation, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,381E-03 0,02369843 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 1,000 1,381E-03 0,02352289 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 1,381E-03 0,02334992 ! mitochondrion localization GO:0051646 12 8 1,000 1,381E-03 0,02317949 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 1,381E-03 0,02301152 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 3,000 1,587E-03 0,02625531 ! positive regulation of cell development GO:0010720 54 33 2,000 1,665E-03 0,02734871 ! regulation of proteolysis GO:0030162 50 33 2,000 1,665E-03 0,02715475 ! steroid biosynthetic process GO:0006694 94 71 3,000 1,672E-03 0,02708609 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 1,767E-03 0,02841826 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 1,767E-03 0,02822091 GO:0010469|regulation of receptor activity, ! lung alveolus development GO:0048286 17 9 1,000 1,767E-03 0,02802628 ! myeloid leukocyte mediated immunity GO:0002444 11 9 1,000 1,767E-03 0,02783432 ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 1,000 1,767E-03 0,02764497 ! regulation of stress fiber formation GO:0051492 20 9 1,000 1,767E-03 0,02745818 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,767E-03 0,0272739 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 1,000 1,767E-03 0,02709207 ! erythrocyte development GO:0048821 11 9 1,000 1,767E-03 0,02691265 ! spleen development GO:0048536 15 9 1,000 1,767E-03 0,0267356 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 1,767E-03 0,02656085 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 1,816E-03 0,0271271 ! protein import into nucleus GO:0006606 118 74 3,000 1,948E-03 0,02890644 ! response to nutrient GO:0007584 104 75 3,000 2,047E-03 0,03017351 ! nuclear import GO:0051170 121 75 3,000 2,047E-03 0,02998132 ! tissue remodeling GO:0048771 62 36 2,000 2,145E-03 0,03122193 ! development of primary female sexual characteristics GO:0046545 52 36 2,000 2,145E-03 0,03102556 GO:0046660|female sex differentiation, ! regulation of cell morphogenesis GO:0022604 140 76 3,000 2,148E-03 0,03088398 ! hair follicle morphogenesis GO:0031069 17 10 1,000 2,198E-03 0,03140388 ! blood vessel remodeling GO:0001974 21 10 1,000 2,198E-03 0,03121003 ! positive regulation of heart contraction GO:0045823 14 10 1,000 2,198E-03 0,03101856 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,198E-03 0,03082942 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 2,198E-03 0,03064258 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,198E-03 0,03045798 ! regulation of bone resorption GO:0045124 24 10 1,000 2,198E-03 0,0302756 ! zymogen activation GO:0031638 14 10 1,000 2,198E-03 0,03009539 ! salivary gland development GO:0007431 22 10 1,000 2,198E-03 0,02991731 ! regulation of actin filament bundle formation GO:0032231 21 10 1,000 2,198E-03 0,02974132 ! cardiac cell differentiation GO:0035051 16 10 1,000 2,198E-03 0,0295674 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 2,000 2,322E-03 0,03104955 GO:0006956|complement activation, ! gliogenesis GO:0042063 71 38 2,000 2,508E-03 0,0333425 ! protein localization in nucleus GO:0034504 133 80 3,000 2,591E-03 0,03425066 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 2,674E-03 0,035147 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 2,674E-03 0,0349473 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 2,674E-03 0,03474986 ! membrane protein proteolysis GO:0033619 18 11 1,000 2,674E-03 0,03455463 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of interleukin-8 production GO:0032677 17 11 1,000 2,674E-03 0,03436159 ! regulation of Rho GTPase activity GO:0032319 18 11 1,000 2,674E-03 0,03417069 ! morphogenesis of embryonic epithelium GO:0016331 60 39 2,000 2,703E-03 0,03434578 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 2,000 2,703E-03 0,03415707 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 2,703E-03 0,03397042 ! regulation of cell cycle process GO:0010564 122 81 3,000 2,711E-03 0,03388589 ! response to calcium ion GO:0051592 58 40 2,000 2,907E-03 0,03613973 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 2,907E-03 0,03594543 ! regulation of cell adhesion GO:0030155 159 83 3,000 2,962E-03 0,03642632 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 3,093E-03 0,03783678 ! cartilage condensation GO:0001502 18 12 1,000 3,194E-03 0,03886993 ! histone acetylation GO:0016573 23 12 1,000 3,194E-03 0,03866535 ! autonomic nervous system development GO:0048483 23 12 1,000 3,194E-03 0,03846291 ! gland morphogenesis GO:0022612 23 12 1,000 3,194E-03 0,03826259 ! peptidyl-lysine modification GO:0018205 18 12 1,000 3,194E-03 0,03806433 ! regulation of epidermis development GO:0045682 17 12 1,000 3,194E-03 0,03786813 ! regulation of mRNA stability GO:0043488 27 12 1,000 3,194E-03 0,03767393 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 3,194E-03 0,03748172 ! negative regulation of multicellular organismal process GO:0051241 133 85 3,000 3,228E-03 0,03768478 ! regulation of cell shape GO:0008360 78 42 2,000 3,343E-03 0,03883035 ! response to insulin stimulus GO:0032868 63 43 2,000 3,575E-03 0,04131811 ! protein processing GO:0016485 114 88 3,000 3,657E-03 0,04205458 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 3,757E-03 0,04299315 ! regulation of chemokine production GO:0032642 17 13 1,000 3,757E-03 0,04278032 ! exocrine system development GO:0035272 27 13 1,000 3,757E-03 0,04256958 ! genitalia development GO:0048806 15 13 1,000 3,757E-03 0,0423609 ! tissue regeneration GO:0042246 21 13 1,000 3,757E-03 0,04215426 ! positive regulation of bone mineralization GO:0030501 19 13 1,000 3,757E-03 0,04194963 ! regulation of RNA stability GO:0043487 28 13 1,000 3,757E-03 0,04174698 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 1,000 3,757E-03 0,04154627 ! regulation of cell projection organization GO:0031344 83 44 2,000 3,817E-03 0,04200156 ! leukocyte differentiation GO:0002521 143 90 3,000 3,964E-03 0,04341065 ! positive regulation of cell cycle GO:0045787 77 45 2,000 4,068E-03 0,04434478 ! cell maturation GO:0048469 60 45 2,000 4,068E-03 0,04413561 ! positive regulation of immune response GO:0050778 121 92 3,000 4,287E-03 0,04629377 ! regulation of ossification GO:0030278 71 46 2,000 4,329E-03 0,04653196 ! neuron maturation GO:0042551 21 14 1,000 4,363E-03 0,04667389 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,363E-03 0,0464578 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 4,363E-03 0,04624371 ! retina development in camera-type eye GO:0060041 18 14 1,000 4,363E-03 0,04603159 ! startle response GO:0001964 21 14 1,000 4,363E-03 0,0458214 ! epidermis morphogenesis GO:0048730 29 14 1,000 4,363E-03 0,04561312 ! cellular response to starvation GO:0009267 21 14 1,000 4,363E-03 0,04540672 ! positive regulation of biomineral formation GO:0070169 20 14 1,000 4,363E-03 0,04520219 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 4,363E-03 0,04499949 ! catecholamine biosynthetic process GO:0042423 23 14 1,000 4,363E-03 0,0447986 ! cell killing GO:0001906 20 14 1,000 4,363E-03 0,04459949 ! response to estrogen stimulus GO:0043627 74 47 2,000 4,601E-03 0,04682238 ! protein maturation GO:0051604 129 96 3,000 4,987E-03 0,05052949 ! regulation of protein ubiquitination GO:0031396 19 15 1,000 5,011E-03 0,05054718 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 5,011E-03 0,05032645 ! lipid phosphorylation GO:0046834 23 15 1,000 5,011E-03 0,05010763 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 5,011E-03 0,04989072 ! cardiac muscle tissue development GO:0048738 23 15 1,000 5,011E-03 0,04967567 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 5,011E-03 0,04946247 ! dopamine metabolic process GO:0042417 30 15 1,000 5,011E-03 0,04925109 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 5,011E-03 0,04904151 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 5,011E-03 0,04883371 ! cartilage development GO:0051216 70 49 2,000 5,174E-03 0,0502095 ! positive regulation of growth GO:0045927 67 50 2,000 5,476E-03 0,05291553 ! protein import GO:0017038 156 99 3,000 5,56E-03 0,05350206 ! protein amino acid acetylation GO:0006473 28 16 1,000 5,7E-03 0,05462419 ! patterning of blood vessels GO:0001569 24 16 1,000 5,7E-03 0,05439753 ! negative regulation of immune response GO:0050777 28 16 1,000 5,7E-03 0,05417275 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 5,7E-03 0,05394981 ! neural crest cell migration GO:0001755 24 16 1,000 5,7E-03 0,05372871 ! neutrophil chemotaxis GO:0030593 21 16 1,000 5,7E-03 0,05350941 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 5,7E-03 0,05329189 ! negative regulation of translation GO:0017148 22 16 1,000 5,7E-03 0,05307613 ! protein localization in organelle GO:0033365 161 100 3,000 5,76E-03 0,05341701 ! regulation of protein catabolic process GO:0042176 77 51 2,000 5,788E-03 0,05346189 ! establishment of organelle localization GO:0051656 85 52 2,000 6,111E-03 0,05621681 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 6,43E-03 0,05891879 ! retinoid metabolic process GO:0001523 22 17 1,000 6,43E-03 0,05868499 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 1,000 6,43E-03 0,05845303 ! vitamin A metabolic process GO:0006776 22 17 1,000 6,43E-03 0,0582229 ! regulation of immunoglobulin production GO:0002637 25 17 1,000 6,43E-03 0,05799458 ! proximal/distal pattern formation GO:0009954 25 17 1,000 6,43E-03 0,05776804 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 6,43E-03 0,05754326 ! DNA catabolic process GO:0006308 67 54 2,000 6,788E-03 0,06051022 ! detection of external stimulus GO:0009581 66 54 2,000 6,788E-03 0,06027659 ! transcription from RNA polymerase III promoter GO:0006383 32 18 1,000 7,2E-03 0,06369151 ! response to retinoic acid GO:0032526 25 18 1,000 7,2E-03 0,06344748 ! peptide cross-linking GO:0018149 31 18 1,000 7,2E-03 0,06320532 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 7,2E-03 0,06296499 ! somitogenesis GO:0001756 24 18 1,000 7,2E-03 0,06272649 ! cellular response to nutrient levels GO:0031669 27 18 1,000 7,2E-03 0,06248979 ! vitamin transport GO:0051180 24 18 1,000 7,2E-03 0,06225486 ! terpenoid metabolic process GO:0006721 24 18 1,000 7,2E-03 0,0620217 ! gut development GO:0048565 26 18 1,000 7,2E-03 0,06179027 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 7,2E-03 0,06156057 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 7,508E-03 0,06395464 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 7,884E-03 0,06691241 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 7,884E-03 0,06666641 ! developmental maturation GO:0021700 75 57 2,000 7,884E-03 0,06642221 ! regeneration GO:0031099 32 19 1,000 8,01E-03 0,06723339 ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 8,01E-03 0,0669889 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 8,01E-03 0,06674619 ! digestive system process GO:0022600 30 19 1,000 8,01E-03 0,06650523 ! response to vitamin A GO:0033189 26 19 1,000 8,01E-03 0,066266 ! response to starvation GO:0042594 30 19 1,000 8,01E-03 0,06602849 ! response to lipopolysaccharide GO:0032496 26 19 1,000 8,01E-03 0,06579267 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 8,01E-03 0,06555853 ! embryonic organ morphogenesis GO:0048562 23 19 1,000 8,01E-03 0,06532606 ! negative regulation of kinase activity GO:0033673 100 58 2,000 8,271E-03 0,0672225 ! protein maturation by peptide bond cleavage GO:0051605 76 58 2,000 8,271E-03 0,0669858 ! response to vitamin GO:0033273 29 20 1,000 8,858E-03 0,0714867 ! collagen fibril organization GO:0030199 45 20 1,000 8,858E-03 0,07123675 ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 8,858E-03 0,07098854 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 8,858E-03 0,07074205 ! regulation of homeostatic process GO:0032844 105 60 2,000 9,079E-03 0,0722546 ! negative regulation of transferase activity GO:0051348 105 61 2,000 9,499E-03 0,07534064 ! gluconeogenesis GO:0006094 25 21 1,000 9,745E-03 0,07702311 ! protein amino acid acylation GO:0043543 37 21 1,000 9,745E-03 0,07675934 ! ovarian follicle development GO:0001541 30 21 1,000 9,745E-03 0,07649736 ! regulation of insulin secretion GO:0050796 26 21 1,000 9,745E-03 0,07623716 ! platelet activation GO:0030168 28 21 1,000 9,745E-03 0,07597873 ! positive regulation of protein secretion GO:0050714 26 21 1,000 9,745E-03 0,07572205 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 9,745E-03 0,07546709 ! regulation of bone mineralization GO:0030500 29 21 1,000 9,745E-03 0,07521385 ! negative regulation of cytokine production GO:0001818 31 21 1,000 9,745E-03 0,07496229 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 2,000 9,931E-03 0,07613925 ! viral genome replication GO:0019079 29 22 1,000 0,01066985 0,08153041 ! molting cycle process GO:0022404 40 22 1,000 0,01066985 0,08126044 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01066985 0,08099225 ! vasculogenesis GO:0001570 33 22 1,000 0,01066985 0,08072583 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 0,01066985 0,08046116 ! barbed-end actin filament capping GO:0051016 33 22 1,000 0,01066985 0,08019821 GO:0051693|actin filament capping, ! neural tube closure GO:0001843 33 22 1,000 0,01066985 0,07993698 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of actin cytoskeleton organization GO:0032956 97 64 2,000 0,01082853 0,08086238 ! adaptive immune response GO:0002250 94 64 2,000 0,01082853 0,08060069 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 2,000 0,01129422 0,08379582 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 2,000 0,01129422 0,08352638 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 0,01129422 0,08325867 ! activation of immune response GO:0002253 83 65 2,000 0,01129422 0,08299267 ! interaction with host GO:0051701 37 23 1,000 0,01163181 0,08520117 ! regulation of biomineral formation GO:0070167 31 23 1,000 0,01163181 0,08493069 ! fat-soluble vitamin metabolic process GO:0006775 28 23 1,000 0,01163181 0,08466192 ! response to molecule of bacterial origin GO:0002237 30 23 1,000 0,01163181 0,08439485 ! liver development GO:0001889 40 23 1,000 0,01163181 0,08412945 ! regulation of actin filament-based process GO:0032970 99 66 2,000 0,01177133 0,08487166 ! cell-substrate adhesion GO:0031589 121 66 2,000 0,01177133 0,08460643 ! pyruvate metabolic process GO:0006090 29 24 1,000 0,01263041 0,09049829 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 0,01263041 0,09021724 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,01263041 0,08993793 ! neural crest cell development GO:0014032 39 24 1,000 0,01263041 0,08966034 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 1,000 0,01263041 0,08938447 ! base-excision repair GO:0006284 31 24 1,000 0,01263041 0,08911028 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,01263041 0,08883777 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,01263041 0,08856693 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,01275998 0,08920351 ! positive regulation of ligase activity GO:0051351 99 69 2,000 0,0132716 0,09249905 ! negative regulation of actin filament depolymerization GO:0030835 36 25 1,000 0,01366509 0,09495381 ! negative regulation of actin filament polymerization GO:0030837 36 25 1,000 0,01366509 0,09466781 ! regulation of peptide secretion GO:0002791 34 25 1,000 0,01366509 0,09438352 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,01366509 0,09410093 ! response to metal ion GO:0010038 103 70 2,000 0,01379481 0,09471061 ! humoral immune response GO:0006959 86 70 2,000 0,01379481 0,09442873 ! eye development GO:0001654 111 70 2,000 0,01379481 0,09414853 ! regulation of catabolic process GO:0009894 106 70 2,000 0,01379481 0,09386998 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01473529 0,09997393 ! negative regulation of protein modification process GO:0031400 50 26 1,000 0,01473529 0,09967989 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 0,01473529 0,09938757 ! negative regulation of protein polymerization GO:0032272 38 26 1,000 0,01473529 0,09909697 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,01487609 0,09975219 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,01543423 0,10319395 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 0,01584045 0,105603 ! catechol metabolic process GO:0009712 43 27 1,000 0,01584045 0,10529778 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,01584045 0,10499433 ! blood coagulation GO:0007596 116 75 2,000 0,01658563 0,10961765 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 2,000 0,01658563 0,10930356 ! phenol metabolic process GO:0018958 44 28 1,000 0,01698003 0,11158305 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01698003 0,11126515 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01698003 0,11094906 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 0,01698003 0,11063475 ! BMP signaling pathway GO:0030509 40 28 1,000 0,01698003 0,11032223 ! neural tube formation GO:0001841 41 28 1,000 0,01698003 0,11001146 ! placenta development GO:0001890 37 28 1,000 0,01698003 0,10970244 ! response to unfolded protein GO:0006986 99 76 2,000 0,01717894 0,11067662 ! sex differentiation GO:0007548 105 77 2,000 0,01778401 0,11425481 ! ovulation cycle process GO:0022602 41 29 1,000 0,01815349 0,11630369 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,01815349 0,11598062 ! eye morphogenesis GO:0048592 51 29 1,000 0,01815349 0,11565934 ! tissue homeostasis GO:0001894 42 29 1,000 0,01815349 0,11533984 GO:0048871|multicellular organismal homeostasis, ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,01936029 0,12266851 ! ovulation cycle GO:0042698 43 30 1,000 0,01936029 0,12233151 ! adult locomotory behavior GO:0008344 47 30 1,000 0,01936029 0,12199635 ! regulation of GTPase activity GO:0043087 129 80 2,000 0,01966997 0,12360909 ! hemostasis GO:0007599 125 81 2,000 0,02032224 0,12736009 ! response to protein stimulus GO:0051789 111 81 2,000 0,02032224 0,12701401 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02059991 0,12840052 ! odontogenesis GO:0042476 50 31 1,000 0,02059991 0,12805349 ! segmentation GO:0035282 41 31 1,000 0,02059991 0,12770833 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02059991 0,12736503 ! leukocyte chemotaxis GO:0030595 43 31 1,000 0,02059991 0,12702357 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 0,02059991 0,12668393 ! RNA modification GO:0009451 40 31 1,000 0,02059991 0,12634611 ! ossification GO:0001503 134 82 2,000 0,02098634 0,12837388 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 2,000 0,02098634 0,12803337 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,02187182 0,1330825 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,02187182 0,13273135 ! RNA export from nucleus GO:0006405 44 33 1,000 0,0231755 0,14027279 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,0231755 0,13990462 ! actomyosin structure organization GO:0031032 43 33 1,000 0,0231755 0,13953837 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,0231755 0,13917404 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 1,000 0,0231755 0,13881161 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,0231755 0,13845106 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02451045 0,14604673 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02451045 0,14566935 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,02451045 0,14529391 ! isoprenoid metabolic process GO:0006720 46 34 1,000 0,02451045 0,14492041 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 0,02451045 0,14454882 ! embryonic organ development GO:0048568 45 34 1,000 0,02451045 0,14417913 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,02451045 0,14381132 ! Notch signaling pathway GO:0007219 56 35 1,000 0,02587616 0,15143807 ! protein homooligomerization GO:0051260 52 35 1,000 0,02587616 0,15105371 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,02596629 0,15119614 ! reproductive developmental process GO:0003006 127 89 2,000 0,02596629 0,15081433 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,02727212 0,15799968 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 1,000 0,02727212 0,15760269 ! neural tube development GO:0021915 50 36 1,000 0,02727212 0,1572077 ! regulation of protein secretion GO:0050708 51 37 1,000 0,02869784 0,16501259 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,0290719 0,16674657 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,03015284 0,17251623 ! maintenance of location in cell GO:0051651 69 38 1,000 0,03015284 0,17208815 ! regulation of response to external stimulus GO:0032101 139 96 2,000 0,03152461 0,17947181 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,03163662 0,17966475 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,03163662 0,17922222 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 0,03163662 0,17878187 ! chromatin remodeling GO:0006338 68 39 1,000 0,03163662 0,17834368 ! developmental growth GO:0048589 62 39 1,000 0,03163662 0,17790763 ! cell growth GO:0016049 61 39 1,000 0,03163662 0,17747371 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,03314871 0,18550373 ! T cell differentiation GO:0030217 65 40 1,000 0,03314871 0,18505347 ! B cell differentiation GO:0030183 62 40 1,000 0,03314871 0,1846054 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,03314871 0,1841595 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,03468864 0,19225027 ! regulation of translation GO:0006417 151 100 2,000 0,0349586 0,1932807 ! regulation of body fluid levels GO:0050878 154 100 2,000 0,0349586 0,19281719 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03524742 0,19394514 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03524742 0,19348226 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03524742 0,19302159 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03524742 0,1925631 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03524742 0,19210679 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03524742 0,19165264 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03524742 0,19120063 ! sleep GO:0030431 11 5 0,000 0,03524742 0,19075075 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03524742 0,19030297 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03524742 0,1898573 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03524742 0,18941371 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03524742 0,18897218 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03524742 0,18853271 ! tongue development GO:0043586 6 5 0,000 0,03524742 0,18809528 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03524742 0,18765988 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03524742 0,18722648 ! cobalt ion transport GO:0006824 9 5 0,000 0,03524742 0,18679509 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03524742 0,18636567 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03524742 0,18593823 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03524742 0,18551274 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03524742 0,18508919 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03524742 0,18466758 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03524742 0,18424788 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03524742 0,18383008 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03524742 0,18341418 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03524742 0,18300015 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03524742 0,18258799 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03524742 0,18217768 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,03524742 0,18176921 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03524742 0,18136257 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03524742 0,18095774 ! malate metabolic process GO:0006108 7 5 0,000 0,03524742 0,18055472 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03524742 0,18015348 ! behavioral response to pain GO:0048266 7 5 0,000 0,03524742 0,17975403 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03524742 0,17935634 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03524742 0,17896041 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03524742 0,17856623 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03524742 0,17817377 ! mating behavior GO:0007617 6 5 0,000 0,03524742 0,17778304 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03524742 0,17739402 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03524742 0,1770067 ! rhythmic behavior GO:0007622 12 5 0,000 0,03524742 0,17662106 ! copulation GO:0007620 7 5 0,000 0,03524742 0,1762371 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03524742 0,17585481 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03524742 0,17547417 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03524742 0,17509518 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03524742 0,17471782 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03524742 0,17434208 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03524742 0,17396796 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03524742 0,17359543 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03524742 0,1732245 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03524742 0,17285515 ! response to protozoan GO:0001562 9 5 0,000 0,03524742 0,17248738 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03524742 0,17212116 ! lymph vessel development GO:0001945 7 5 0,000 0,03524742 0,1717565 ! endochondral ossification GO:0001958 12 5 0,000 0,03524742 0,17139338 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03524742 0,17103179 ! parathyroid gland development GO:0060017 8 5 0,000 0,03524742 0,17067172 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03524742 0,17031317 ! anagen GO:0042640 6 5 0,000 0,03524742 0,16995612 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03524742 0,16960056 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03524742 0,16924649 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03524742 0,16889389 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03524742 0,16854276 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03524742 0,16819309 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03524742 0,16784486 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03524742 0,16749807 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03524742 0,16715272 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03524742 0,16680878 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03524742 0,16646626 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,03524742 0,16612514 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03524742 0,16578541 ! ovulation GO:0030728 6 5 0,000 0,03524742 0,16544708 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03524742 0,16511012 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,03524742 0,16477453 ! response to pH GO:0009268 9 5 0,000 0,03524742 0,1644403 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03524742 0,16410742 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03524742 0,16377589 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03524742 0,1634457 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03524742 0,16311684 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03524742 0,16278929 ! polyol catabolic process GO:0046174 7 5 0,000 0,03524742 0,16246306 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03524742 0,16213813 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03524742 0,16181451 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03524742 0,16149217 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03524742 0,16117111 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03524742 0,16085132 ! urea metabolic process GO:0019627 6 5 0,000 0,03524742 0,16053281 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03524742 0,16021555 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03524742 0,15989954 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03524742 0,15958478 ! neutrophil activation GO:0042119 5 5 0,000 0,03524742 0,15927125 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03524742 0,15895896 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03524742 0,15864788 ! response to food GO:0032094 5 5 0,000 0,03524742 0,15833802 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03524742 0,15802937 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03524742 0,15772192 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03524742 0,15741566 ! forebrain neuron development GO:0021884 7 5 0,000 0,03524742 0,1571106 ! melanosome organization GO:0032438 7 5 0,000 0,03524742 0,15680671 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03524742 0,15650399 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03524742 0,15620244 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03524742 0,15590205 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03524742 0,15560282 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03524742 0,15530473 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03524742 0,15500778 ! nucleoside transport GO:0015858 6 5 0,000 0,03524742 0,15471196 ! nucleoside salvage GO:0043174 7 5 0,000 0,03524742 0,15441727 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03524742 0,1541237 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03524742 0,15383125 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03524742 0,1535399 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03524742 0,15324965 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03524742 0,1529605 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03524742 0,15267244 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03524742 0,15238546 ! depyrimidination GO:0045008 8 5 0,000 0,03524742 0,15209956 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03524742 0,15181473 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03524742 0,15153097 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03524742 0,15124826 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03524742 0,15096661 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03524742 0,150686 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03524742 0,15040643 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03524742 0,1501279 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03524742 0,1498504 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03524742 0,14957392 ! monocyte differentiation GO:0030224 8 5 0,000 0,03524742 0,14929847 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03524742 0,14902402 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03524742 0,14875058 ! centrosome duplication GO:0051298 5 5 0,000 0,03524742 0,14847814 ! response to UV-C GO:0010225 6 5 0,000 0,03524742 0,1482067 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03524742 0,14793625 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03524742 0,14766679 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03524742 0,1473983 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03524742 0,14713079 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03524742 0,14686425 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03524742 0,14659867 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03524742 0,14633406 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03524742 0,14607039 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03524742 0,14580767 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03524742 0,1455459 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03524742 0,14528507 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03524742 0,14502516 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03524742 0,14476619 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03524742 0,14450814 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03524742 0,14425101 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03524742 0,14399479 ! neural tube patterning GO:0021532 6 5 0,000 0,03524742 0,14373948 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03524742 0,14348507 ! histone demethylation GO:0016577 9 5 0,000 0,03524742 0,14323157 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03524742 0,14297895 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03524742 0,14272723 GO:0032374|regulation of cholesterol transport, ! establishment of planar polarity GO:0001736 6 5 0,000 0,03524742 0,14247639 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03524742 0,14222643 ! transcription termination GO:0006353 8 5 0,000 0,03524742 0,14197735 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03524742 0,14172914 ! plasminogen activation GO:0031639 5 5 0,000 0,03524742 0,14148179 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03524742 0,14123531 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03524742 0,14098968 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03524742 0,14074491 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03524742 0,14050098 GO:0015991|ATP hydrolysis coupled proton transport, ! protein destabilization GO:0031648 6 5 0,000 0,03524742 0,1402579 ! apical protein localization GO:0045176 6 5 0,000 0,03524742 0,14001566 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03524742 0,13977425 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03524742 0,13953368 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03524742 0,13929393 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03524742 0,139055 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03524742 0,1388169 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03524742 0,1385796 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03524742 0,13834312 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03524742 0,13810744 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03524742 0,13787256 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03524742 0,13763848 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03524742 0,1374052 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03524742 0,1371727 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03524742 0,13694099 ! neural plate development GO:0001840 6 5 0,000 0,03524742 0,13671006 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03524742 0,13647991 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03524742 0,13625053 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03524742 0,13602192 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03524742 0,13579408 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03524742 0,135567 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03524742 0,13534068 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03524742 0,13511511 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03524742 0,13489029 ! spindle assembly GO:0051225 5 5 0,000 0,03524742 0,13466622 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03524742 0,1344429 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03524742 0,13422031 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03524742 0,13399846 ! organ regeneration GO:0031100 7 5 0,000 0,03524742 0,13377734 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03524742 0,13355695 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03524742 0,13333728 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03524742 0,13311834 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03524742 0,13290011 GO:0055081|anion homeostasis, ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,03625593 0,13647894 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,03625593 0,13625594 ! positive regulation of binding GO:0051099 59 43 1,000 0,03785012 0,14201514 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 0,03785012 0,14178385 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,03785012 0,14155331 ! leukocyte migration GO:0050900 60 43 1,000 0,03785012 0,14132351 ! neuromuscular process GO:0050905 79 43 1,000 0,03785012 0,14109446 ! tRNA processing GO:0008033 49 43 1,000 0,03785012 0,14086615 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,03947076 0,14666035 ! regulation of translational initiation GO:0006446 64 45 1,000 0,0411174 0,15253228 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,0411174 0,15228666 ! tRNA transcription GO:0009304 11 6 0,000 0,04214758 0,15585118 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04214758 0,15560101 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04214758 0,15535165 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04214758 0,15510309 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04214758 0,15485532 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04214758 0,15460834 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04214758 0,15436215 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04214758 0,15411674 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04214758 0,15387211 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04214758 0,15362826 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04214758 0,15338518 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04214758 0,15314286 ! prostate gland development GO:0030850 9 6 0,000 0,04214758 0,15290131 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04214758 0,15266052 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04214758 0,15242049 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04214758 0,15218121 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04214758 0,15194268 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04214758 0,1517049 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04214758 0,15146786 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04214758 0,15123156 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04214758 0,150996 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04214758 0,15076117 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,04214758 0,15052707 ! neuron adhesion GO:0007158 9 6 0,000 0,04214758 0,15029369 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04214758 0,15006104 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04214758 0,14982911 ! signal peptide processing GO:0006465 8 6 0,000 0,04214758 0,14959789 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04214758 0,14936738 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04214758 0,14913759 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04214758 0,1489085 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04214758 0,14868011 ! opsonization GO:0008228 8 6 0,000 0,04214758 0,14845242 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04214758 0,14822543 GO:0042069|regulation of catecholamine metabolic process, ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04214758 0,14799913 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04214758 0,14777352 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04214758 0,1475486 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04214758 0,14732436 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04214758 0,14710081 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04214758 0,14687793 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04214758 0,14665572 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04214758 0,14643419 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04214758 0,14621332 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04214758 0,14599312 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04214758 0,14577358 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04214758 0,1455547 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04214758 0,14533648 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04214758 0,14511891 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04214758 0,14490199 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04214758 0,14468572 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04214758 0,14447009 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04214758 0,14425511 ! thymic T cell selection GO:0045061 12 6 0,000 0,04214758 0,14404076 ! protein lipoylation GO:0009249 10 6 0,000 0,04214758 0,14382705 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04214758 0,14361397 ! pigment granule organization GO:0048753 11 6 0,000 0,04214758 0,14340153 ! drug transport GO:0015893 6 6 0,000 0,04214758 0,14318971 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04214758 0,14297851 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04214758 0,14276794 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04214758 0,14255799 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04214758 0,14234865 ! histidine metabolic process GO:0006547 6 6 0,000 0,04214758 0,14213993 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04214758 0,14193182 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04214758 0,14172432 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04214758 0,14151742 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04214758 0,14131113 ! adenohypophysis development GO:0021984 10 6 0,000 0,04214758 0,14110543 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04214758 0,14090034 ! hyperosmotic response GO:0006972 8 6 0,000 0,04214758 0,14069584 ! microtubule nucleation GO:0007020 10 6 0,000 0,04214758 0,14049193 ! ER overload response GO:0006983 7 6 0,000 0,04214758 0,14028861 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04214758 0,14008588 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04214758 0,13988374 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04214758 0,13968218 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04214758 0,1394812 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04214758 0,13928079 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04214758 0,13908096 ! response to dietary excess GO:0002021 7 6 0,000 0,04214758 0,13888171 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04214758 0,13868302 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04214758 0,1384849 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04214758 0,13828735 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04214758 0,13809036 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04214758 0,13789393 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04214758 0,13769806 ! neuron apoptosis GO:0051402 8 6 0,000 0,04214758 0,13750274 ! organic alcohol transport GO:0015850 9 6 0,000 0,04214758 0,13730798 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04214758 0,13711377 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04214758 0,1369201 ! male sex determination GO:0030238 9 6 0,000 0,04214758 0,13672698 ! carnitine transport GO:0015879 8 6 0,000 0,04214758 0,13653441 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04214758 0,13634238 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04214758 0,13615089 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04214758 0,13595993 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04214758 0,13576951 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04214758 0,13557963 ! parturition GO:0007567 12 6 0,000 0,04214758 0,13539027 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04214758 0,13520144 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04214758 0,13501314 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04214758 0,13482536 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04214758 0,1346381 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04214758 0,13445136 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04214758 0,13426514 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04214758 0,13407944 ! astrocyte development GO:0014002 14 6 0,000 0,04214758 0,13389424 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04214758 0,13370956 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04214758 0,13352539 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04214758 0,13334172 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04214758 0,13315856 ! eating behavior GO:0042755 6 6 0,000 0,04214758 0,1329759 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04214758 0,13279374 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04214758 0,13261208 ! response to copper ion GO:0046688 9 6 0,000 0,04214758 0,13243092 ! DNA topological change GO:0006265 8 6 0,000 0,04214758 0,13225025 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04214758 0,13207007 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04214758 0,13189038 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04214758 0,13171118 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04214758 0,13153247 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04214758 0,13135424 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04214758 0,1311765 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04214758 0,13099923 ! gas homeostasis GO:0033483 11 6 0,000 0,04214758 0,13082245 ! hair follicle maturation GO:0048820 7 6 0,000 0,04214758 0,13064613 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04214758 0,1304703 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04214758 0,13029494 ! Schwann cell development GO:0014044 14 6 0,000 0,04214758 0,13012004 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04214758 0,12994562 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04214758 0,12977166 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04214758 0,12959817 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04214758 0,12942514 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04214758 0,12925258 ! histone ubiquitination GO:0016574 7 6 0,000 0,04214758 0,12908047 ! regulation of meiosis GO:0040020 10 6 0,000 0,04214758 0,12890882 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04214758 0,12873763 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04214758 0,12856689 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04214758 0,1283966 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04214758 0,12822676 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04214758 0,12805737 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04214758 0,12788843 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04214758 0,12771994 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04214758 0,12755188 ! receptor internalization GO:0031623 9 6 0,000 0,04214758 0,12738427 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04214758 0,1272171 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04214758 0,12705037 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04214758 0,12688407 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 8 6 0,000 0,04214758 0,12671821 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04214758 0,12655278 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,04214758 0,12638779 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04214758 0,12622322 ! axonal fasciculation GO:0007413 9 6 0,000 0,04214758 0,12605908 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04214758 0,12589537 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04214758 0,12573208 ! midbrain development GO:0030901 6 6 0,000 0,04214758 0,12556921 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04214758 0,12540677 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04214758 0,12524474 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04214758 0,12508314 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04214758 0,12492195 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04214758 0,12476117 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04214758 0,12460081 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04214758 0,12444086 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04214758 0,12428132 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04214758 0,12412219 ! adult feeding behavior GO:0008343 6 6 0,000 0,04214758 0,12396347 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04214758 0,12380515 ! blastocyst growth GO:0001832 15 6 0,000 0,04214758 0,12364723 ! pigment granule transport GO:0051904 12 6 0,000 0,04214758 0,12348972 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04214758 0,12333261 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04214758 0,1231759 ! catecholamine transport GO:0051937 7 6 0,000 0,04214758 0,12301958 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04214758 0,12286367 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04214758 0,12270814 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04214758 0,12255301 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,04214758 0,12239827 ! protein prenylation GO:0018342 10 6 0,000 0,04214758 0,12224392 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04214758 0,12208996 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04214758 0,12193639 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04214758 0,12178321 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04214758 0,1216304 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,04278957 0,12332835 ! histone modification GO:0016570 68 46 1,000 0,04278957 0,12317399 ! viral infectious cycle GO:0019058 71 47 1,000 0,04448685 0,1278997 ! covalent chromatin modification GO:0016569 75 47 1,000 0,04448685 0,12774003 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,04448685 0,12758075 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,04448685 0,12742187 ! regulation of protein polymerization GO:0032271 71 47 1,000 0,04448685 0,12726339 ! regulation of muscle contraction GO:0006937 69 48 1,000 0,04620879 0,13202513 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,04620879 0,13186133 ! regulation of DNA replication GO:0006275 75 48 1,000 0,04620879 0,13169793 ! regulation of endocytosis GO:0030100 63 48 1,000 0,04620879 0,13153494 ! nuclear export GO:0051168 69 48 1,000 0,04620879 0,13137235 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,04620879 0,13121016 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,04795497 0,13600052 ! maintenance of location GO:0051235 84 49 1,000 0,04795497 0,13583303 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04899878 0,13861893 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04899878 0,13844864 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04899878 0,13827876 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04899878 0,1381093 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04899878 0,13794026 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04899878 0,13777163 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04899878 0,13760341 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04899878 0,1374356 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04899878 0,1372682 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04899878 0,1371012 ! reproductive behavior GO:0019098 12 7 0,000 0,04899878 0,13693462 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04899878 0,13676843 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04899878 0,13660265 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,04899878 0,13643728 ! oligopeptide transport GO:0006857 11 7 0,000 0,04899878 0,1362723 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04899878 0,13610772 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04899878 0,13594353 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04899878 0,13577975 ! RNA methylation GO:0001510 11 7 0,000 0,04899878 0,13561635 ! pericardium development GO:0060039 8 7 0,000 0,04899878 0,13545335 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04899878 0,13529074 ! fibril organization GO:0043206 13 7 0,000 0,04899878 0,13512852 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04899878 0,13496669 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04899878 0,13480525 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,04899878 0,13464419 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04899878 0,13448352 ! lipoprotein transport GO:0042953 9 7 0,000 0,04899878 0,13432323 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04899878 0,13416332 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04899878 0,13400379 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04899878 0,13384464 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04899878 0,13368587 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04899878 0,13352748 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04899878 0,13336946 ! chemosensory behavior GO:0007635 9 7 0,000 0,04899878 0,13321181 ! microtubule bundle formation GO:0001578 8 7 0,000 0,04899878 0,13305453 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04899878 0,13289763 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04899878 0,13274109 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04899878 0,13258493 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04899878 0,13242913 ! reflex GO:0060004 12 7 0,000 0,04899878 0,1322737 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04899878 0,13211863 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04899878 0,13196392 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04899878 0,13180958 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04899878 0,1316556 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04899878 0,13150197 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04899878 0,13134871 ! spinal cord patterning GO:0021511 7 7 0,000 0,04899878 0,1311958 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04899878 0,13104324 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04899878 0,13089104 ! adrenal gland development GO:0030325 17 7 0,000 0,04899878 0,1307392 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04899878 0,13058771 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04899878 0,13043656 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04899878 0,13028577 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04899878 0,13013532 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04899878 0,12998522 ! endosome organization GO:0007032 10 7 0,000 0,04899878 0,12983547 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04899878 0,12968606 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04899878 0,129537 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04899878 0,12938828 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,04899878 0,1292399 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04899878 0,12909186 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04899878 0,12894415 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04899878 0,12879679 ! galactose metabolic process GO:0006012 10 7 0,000 0,04899878 0,12864976 ! vesicle fusion GO:0006906 15 7 0,000 0,04899878 0,12850307 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04899878 0,12835671 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04899878 0,12821068 ! organ growth GO:0035265 11 7 0,000 0,04899878 0,12806499 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04899878 0,12791962 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04899878 0,12777459 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04899878 0,12762989 ! behavioral fear response GO:0001662 13 7 0,000 0,04899878 0,12748551 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04899878 0,12734146 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04899878 0,12719773 ! rRNA modification GO:0000154 12 7 0,000 0,04899878 0,12705433 ! protein heterooligomerization GO:0051291 10 7 0,000 0,04899878 0,12691125 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04899878 0,12676849 ! response to UV-B GO:0010224 11 7 0,000 0,04899878 0,12662606 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,04899878 0,12648394 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04899878 0,12634214 ! intermediate filament organization GO:0045109 11 7 0,000 0,04899878 0,12620066 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04899878 0,1260595 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04899878 0,12591865 ! fibrinolysis GO:0042730 9 7 0,000 0,04899878 0,12577811 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,04899878 0,12563789 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04899878 0,12549798 ! B cell lineage commitment GO:0002326 17 7 0,000 0,04899878 0,12535839 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04899878 0,1252191 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04899878 0,12508012 ! response to tropane GO:0014073 13 7 0,000 0,04899878 0,12494145 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04899878 0,12480309 ! melanosome localization GO:0032400 10 7 0,000 0,04899878 0,12466503 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04899878 0,12452728 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04899878 0,12438983 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04899878 0,12425269 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04899878 0,12411585 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04899878 0,12397931 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04899878 0,12384307 ! mast cell activation GO:0045576 9 7 0,000 0,04899878 0,12370712 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04899878 0,12357148 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04899878 0,12343613 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04899878 0,12330108 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04899878 0,12316633 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04899878 0,12303187 ! T cell lineage commitment GO:0002360 12 7 0,000 0,04899878 0,1228977 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04899878 0,12276382 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04899878 0,12263024 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04899878 0,12249695 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04899878 0,12236394 ! response to tumor cell GO:0002347 12 7 0,000 0,04899878 0,12223123 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04899878 0,1220988 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04899878 0,12196666 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04899878 0,1218348 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04899878 0,12170323 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,04899878 0,12157194 ! diuresis GO:0030146 12 7 0,000 0,04899878 0,12144094 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04899878 0,12131021 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04899878 0,12117977 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04899878 0,12104961 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04899878 0,12091973 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04899878 0,12079013 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04899878 0,1206608 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04899878 0,12053175 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,04899878 0,12040298 ! lymph node development GO:0048535 9 7 0,000 0,04899878 0,12027448 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04899878 0,12014626 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04899878 0,12001831 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04899878 0,11989063 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04899878 0,11976322 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04899878 0,11963608 ! ATP catabolic process GO:0006200 10 7 0,000 0,04899878 0,11950921 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04899878 0,11938262 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04899878 0,11925629 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04899878 0,11913022 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04899878 0,11900442 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04899878 0,11887889 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04899878 0,11875362 ! muscle adaptation GO:0043500 12 7 0,000 0,04899878 0,11862862 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04899878 0,11850388 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04899878 0,1183794 ! retina homeostasis GO:0001895 9 7 0,000 0,04899878 0,11825518 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04899878 0,11813123 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04899878 0,11800753 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04899878 0,11788409 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04899878 0,11776091 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04899878 0,11763798 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04899878 0,11751532 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04899878 0,11739291 ! lipid modification GO:0030258 73 50 1,000 0,04972494 0,1190087 ! regulation of actin filament length GO:0030832 72 50 1,000 0,04972494 0,11888499 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,04972494 0,11876154 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,04972494 0,11863834 ! positive regulation of secretion GO:0051047 71 51 1,000 0,05151829 0,12278971 ! adult behavior GO:0030534 80 51 1,000 0,05151829 0,1226626 ! regulation of cellular component size GO:0032535 74 52 1,000 0,0533346 0,12685583 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,05517346 0,13109396 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05580136 0,13244905 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05580136 0,13231251 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,05580136 0,13217624 ! axon extension GO:0048675 11 8 0,000 0,05580136 0,13204026 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,05580136 0,13190456 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05580136 0,13176913 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05580136 0,13163398 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05580136 0,13149911 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05580136 0,13136452 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05580136 0,1312302 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,05580136 0,13109615 ! phosphate transport GO:0006817 10 8 0,000 0,05580136 0,13096238 ! N-glycan processing GO:0006491 12 8 0,000 0,05580136 0,13082888 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05580136 0,13069565 ! UTP metabolic process GO:0046051 8 8 0,000 0,05580136 0,1305627 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05580136 0,13043001 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05580136 0,1302976 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05580136 0,13016545 ! succinate metabolic process GO:0006105 14 8 0,000 0,05580136 0,13003357 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,05580136 0,12990196 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05580136 0,12977061 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05580136 0,12963953 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,05580136 0,12950871 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05580136 0,12937816 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,05580136 0,12924787 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05580136 0,12911784 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05580136 0,12898807 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05580136 0,12885857 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05580136 0,12872932 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05580136 0,12860033 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05580136 0,1284716 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05580136 0,12834313 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05580136 0,12821492 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05580136 0,12808696 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05580136 0,12795925 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05580136 0,12783181 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05580136 0,12770461 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05580136 0,12757767 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05580136 0,12745098 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05580136 0,12732454 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05580136 0,12719835 ! melanin metabolic process GO:0006582 12 8 0,000 0,05580136 0,12707241 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05580136 0,12694672 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05580136 0,12682128 ! macrophage activation GO:0042116 12 8 0,000 0,05580136 0,12669608 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05580136 0,12657114 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05580136 0,12644644 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,05580136 0,12632198 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05580136 0,12619777 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05580136 0,1260738 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05580136 0,12595008 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05580136 0,1258266 ! ruffle organization GO:0031529 11 8 0,000 0,05580136 0,12570336 ! osteoblast development GO:0002076 13 8 0,000 0,05580136 0,12558036 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05580136 0,12545761 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05580136 0,12533509 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05580136 0,12521281 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05580136 0,12509077 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05580136 0,12496897 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05580136 0,12484741 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05580136 0,12472608 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05580136 0,12460498 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05580136 0,12448412 ! brain morphogenesis GO:0048854 20 8 0,000 0,05580136 0,1243635 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05580136 0,12424311 ! segment specification GO:0007379 10 8 0,000 0,05580136 0,12412295 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05580136 0,12400303 ! cellular extravasation GO:0045123 11 8 0,000 0,05580136 0,12388333 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05580136 0,12376387 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05580136 0,12364464 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05580136 0,12352563 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,05580136 0,12340686 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05580136 0,12328831 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05580136 0,12316999 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05580136 0,1230519 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,05580136 0,12293403 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05580136 0,12281639 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05580136 0,12269898 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05580136 0,12258179 ! icosanoid secretion GO:0032309 12 8 0,000 0,05580136 0,12246482 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05580136 0,12234808 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05580136 0,12223155 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05580136 0,12211525 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05580136 0,12199918 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05580136 0,12188332 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05580136 0,12176768 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05580136 0,12165226 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05580136 0,12153706 ! sterol catabolic process GO:0016127 9 8 0,000 0,05580136 0,12142207 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05580136 0,12130731 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05580136 0,12119276 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05580136 0,12107843 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05580136 0,12096431 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05580136 0,12085041 ! prophase GO:0051324 11 8 0,000 0,05580136 0,12073672 ! S phase GO:0051320 8 8 0,000 0,05580136 0,12062324 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05580136 0,12050998 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05580136 0,12039693 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05580136 0,1202841 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05580136 0,12017147 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05580136 0,12005906 ! hormone catabolic process GO:0042447 13 8 0,000 0,05580136 0,11994685 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05580136 0,11983486 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05580136 0,11972307 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05580136 0,11961149 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05580136 0,11950012 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05580136 0,11938896 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,05580136 0,119278 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05580136 0,11916725 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05580136 0,11905671 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05580136 0,11894637 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05580136 0,11883623 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05580136 0,1187263 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05580136 0,11861657 ! regulation of embryonic development GO:0045995 16 8 0,000 0,05580136 0,11850705 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05580136 0,11839772 GO:0000076|DNA replication checkpoint, ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,06082123 0,12892979 ! negative regulation of response to stimulus GO:0048585 80 56 1,000 0,06082123 0,12881107 ! regulation of developmental growth GO:0048638 13 9 0,000 0,06255567 0,13236251 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,06255567 0,13224085 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06255567 0,13211942 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06255567 0,13199821 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06255567 0,13187722 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06255567 0,13175645 ! CTP metabolic process GO:0046036 9 9 0,000 0,06255567 0,13163591 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! GTP metabolic process GO:0046039 9 9 0,000 0,06255567 0,13151558 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06255567 0,13139548 ! social behavior GO:0035176 14 9 0,000 0,06255567 0,13127559 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06255567 0,13115592 ! artery development GO:0060840 19 9 0,000 0,06255567 0,13103647 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06255567 0,13091724 ! regulation of glycolysis GO:0006110 15 9 0,000 0,06255567 0,13079823 ! response to pain GO:0048265 16 9 0,000 0,06255567 0,13067943 ! protein complex disassembly GO:0043241 17 9 0,000 0,06255567 0,13056084 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06255567 0,13044247 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06255567 0,13032432 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06255567 0,13020638 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06255567 0,13008865 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06255567 0,12997114 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06255567 0,12985383 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06255567 0,12973674 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06255567 0,12961986 ! protein targeting to ER GO:0045047 19 9 0,000 0,06255567 0,12950319 ! T cell selection GO:0045058 18 9 0,000 0,06255567 0,12938673 ! endoderm development GO:0007492 12 9 0,000 0,06255567 0,12927048 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06255567 0,12915444 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06255567 0,12903861 ! arginine catabolic process GO:0006527 10 9 0,000 0,06255567 0,12892298 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06255567 0,12880756 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06255567 0,12869235 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06255567 0,12857734 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,06255567 0,12846254 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06255567 0,12834795 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06255567 0,12823355 ! mannose metabolic process GO:0006013 9 9 0,000 0,06255567 0,12811937 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06255567 0,12800538 ! receptor clustering GO:0043113 15 9 0,000 0,06255567 0,1278916 ! epithelial cell development GO:0002064 10 9 0,000 0,06255567 0,12777802 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06255567 0,12766464 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06255567 0,12755146 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06255567 0,12743848 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06255567 0,12732571 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06255567 0,12721313 ! motor axon guidance GO:0008045 14 9 0,000 0,06255567 0,12710075 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06255567 0,12698857 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06255567 0,12687659 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06255567 0,1267648 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06255567 0,12665321 ! DNA ligation GO:0006266 14 9 0,000 0,06255567 0,12654182 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06255567 0,12643062 ! response to amine stimulus GO:0014075 13 9 0,000 0,06255567 0,12631962 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06255567 0,12620881 ! renal water homeostasis GO:0003091 14 9 0,000 0,06255567 0,1260982 ! postreplication repair GO:0006301 11 9 0,000 0,06255567 0,12598778 ! mRNA cleavage GO:0006379 13 9 0,000 0,06255567 0,12587756 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06255567 0,12576752 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06255567 0,12565768 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06255567 0,12554803 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06255567 0,12543858 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06255567 0,12532931 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06255567 0,12522023 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06255567 0,12511135 ! acid secretion GO:0046717 14 9 0,000 0,06255567 0,12500265 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06255567 0,12489414 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06255567 0,12478582 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06255567 0,12467768 ! purine base metabolic process GO:0006144 18 9 0,000 0,06255567 0,12456974 ! oocyte differentiation GO:0009994 12 9 0,000 0,06255567 0,12446198 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,06255567 0,12435441 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06255567 0,12424702 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06255567 0,12413982 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06255567 0,1240328 ! detection of calcium ion GO:0005513 13 9 0,000 0,06255567 0,12392597 ! blastocyst formation GO:0001825 12 9 0,000 0,06255567 0,12381932 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06255567 0,12371285 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06255567 0,12360657 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06255567 0,12350047 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06255567 0,12339455 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06255567 0,12328882 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06255567 0,12318326 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06255567 0,12307789 ! prepulse inhibition GO:0060134 14 9 0,000 0,06255567 0,12297269 ! embryonic placenta development GO:0001892 12 9 0,000 0,06255567 0,12286768 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06255567 0,12276284 ! insulin secretion GO:0030073 17 9 0,000 0,06255567 0,12265818 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06255567 0,1225537 ! response to nicotine GO:0035094 16 9 0,000 0,06255567 0,1224494 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06255567 0,12234528 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06255567 0,12224133 ! localization within membrane GO:0051668 15 9 0,000 0,06255567 0,12213756 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,06274622 0,12240568 GO:0048609|reproductive process in a multicellular organism, ! camera-type eye development GO:0043010 88 57 1,000 0,06274622 0,12230195 ! secondary metabolic process GO:0019748 84 57 1,000 0,06274622 0,12219839 ! gonad development GO:0008406 79 57 1,000 0,06274622 0,12209501 ! viral reproductive process GO:0022415 87 58 1,000 0,06469175 0,12577432 ! actin filament organization GO:0007015 95 59 1,000 0,06665744 0,12948658 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,0686429 0,13323095 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,0686429 0,13311862 GO:0035113|embryonic appendage morphogenesis, ! regulation of heart contraction GO:0008016 91 60 1,000 0,0686429 0,13300647 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,0686429 0,13289451 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,06926205 0,13398042 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06926205 0,13386783 ! neuron fate specification GO:0048665 11 10 0,000 0,06926205 0,13375543 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,06926205 0,13364322 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,06926205 0,1335312 ! thyroid gland development GO:0030878 19 10 0,000 0,06926205 0,13341936 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,06926205 0,13330771 ! synapsis GO:0007129 13 10 0,000 0,06926205 0,13319625 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06926205 0,13308498 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,06926205 0,13297389 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06926205 0,13286298 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,06926205 0,13275226 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06926205 0,13264173 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,06926205 0,13253138 ! phospholipid efflux GO:0033700 16 10 0,000 0,06926205 0,13242121 ! hippocampus development GO:0021766 19 10 0,000 0,06926205 0,13231123 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,06926205 0,13220142 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06926205 0,1320918 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,06926205 0,13198237 ! pathogenesis GO:0009405 13 10 0,000 0,06926205 0,13187311 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06926205 0,13176403 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06926205 0,13165514 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06926205 0,13154642 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,06926205 0,13143789 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06926205 0,13132953 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06926205 0,13122135 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,06926205 0,13111335 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06926205 0,13100552 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06926205 0,13089788 ! response to X-ray GO:0010165 16 10 0,000 0,06926205 0,13079041 ! B cell proliferation GO:0042100 14 10 0,000 0,06926205 0,13068311 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,06926205 0,130576 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,06926205 0,13046906 ! forebrain cell migration GO:0021885 17 10 0,000 0,06926205 0,13036229 ! lipid digestion GO:0044241 15 10 0,000 0,06926205 0,1302557 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06926205 0,13014928 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,06926205 0,13004303 ! UV protection GO:0009650 14 10 0,000 0,06926205 0,12993696 ! entry into host cell GO:0030260 20 10 0,000 0,06926205 0,12983106 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,06926205 0,12972534 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06926205 0,12961979 ! negative regulation of ossification GO:0030279 19 10 0,000 0,06926205 0,1295144 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,06926205 0,12940919 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,06926205 0,12930415 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,06926205 0,12919928 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06926205 0,12909458 ! regulation of organ growth GO:0046620 11 10 0,000 0,06926205 0,12899005 ! response to dsRNA GO:0043331 18 10 0,000 0,06926205 0,12888569 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06926205 0,1287815 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06926205 0,12867748 ! embryonic axis specification GO:0000578 12 10 0,000 0,06926205 0,12857362 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,06926205 0,12846993 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,06926205 0,12836641 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,06926205 0,12826306 ! cranial nerve development GO:0021545 12 10 0,000 0,06926205 0,12815987 ! fucose catabolic process GO:0019317 16 10 0,000 0,06926205 0,12805685 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,06926205 0,12795399 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,06926205 0,1278513 ! protein sumoylation GO:0016925 12 10 0,000 0,06926205 0,12774877 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06926205 0,12764641 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06926205 0,12754421 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06926205 0,12744217 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,06926205 0,1273403 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,06926205 0,12723859 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06926205 0,12713704 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,06926205 0,12703566 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06926205 0,12693444 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06926205 0,12683337 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06926205 0,12673247 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,06926205 0,12663173 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06926205 0,12653115 ! embryonic gut development GO:0048566 11 10 0,000 0,06926205 0,12643073 ! activation of innate immune response GO:0002218 10 10 0,000 0,06926205 0,12633047 GO:0002758|innate immune response-activating signal transduction, ! developmental induction GO:0031128 13 10 0,000 0,06926205 0,12623036 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,06926205 0,12613042 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,06926205 0,12603063 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06926205 0,125931 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,06926205 0,12583153 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,07064777 0,12824772 ! meiosis GO:0007126 96 61 1,000 0,07064777 0,12814658 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,07064777 0,1280456 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,07064777 0,12794477 ! extracellular matrix organization GO:0030198 103 61 1,000 0,07064777 0,12784411 ! cellular hormone metabolic process GO:0034754 87 62 1,000 0,07267165 0,13140314 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,07267165 0,13129992 ! meiotic cell cycle GO:0051321 97 62 1,000 0,07267165 0,13119686 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,07471419 0,13477854 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,07471419 0,13467292 ! viral reproduction GO:0016032 92 63 1,000 0,07471419 0,13456745 ! rRNA transcription GO:0009303 17 11 0,000 0,07592083 0,13663374 ! respiratory burst GO:0045730 14 11 0,000 0,07592083 0,13652691 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07592083 0,13642025 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07592083 0,13631375 ! virus-host interaction GO:0019048 17 11 0,000 0,07592083 0,13620742 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,07592083 0,13610126 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,07592083 0,13599526 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07592083 0,13588943 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07592083 0,13578376 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,07592083 0,13567826 ! mating GO:0007618 14 11 0,000 0,07592083 0,13557292 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,07592083 0,13546774 ! T cell proliferation GO:0042098 20 11 0,000 0,07592083 0,13536273 ! bone resorption GO:0045453 16 11 0,000 0,07592083 0,13525787 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07592083 0,13515319 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07592083 0,13504866 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! regulation of mRNA processing GO:0050684 18 11 0,000 0,07592083 0,13494429 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07592083 0,13484009 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07592083 0,13473605 ! syncytium formation GO:0006949 15 11 0,000 0,07592083 0,13463216 ! plasma membrane organization GO:0007009 18 11 0,000 0,07592083 0,13452844 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,07592083 0,13442488 ! focal adhesion formation GO:0048041 24 11 0,000 0,07592083 0,13432147 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07592083 0,13421823 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07592083 0,13411514 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,07592083 0,13401221 ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07592083 0,13390944 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,07592083 0,13380683 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,07592083 0,13370438 ! temperature homeostasis GO:0001659 16 11 0,000 0,07592083 0,13360208 ! L-glutamate transport GO:0015813 16 11 0,000 0,07592083 0,13349994 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,07592083 0,13339795 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07592083 0,13329612 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07592083 0,13319444 ! stem cell development GO:0048864 29 11 0,000 0,07592083 0,13309292 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07592083 0,13299156 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07592083 0,13289035 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07592083 0,13278929 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,07592083 0,13268839 ! vasoconstriction GO:0042310 15 11 0,000 0,07592083 0,13258764 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,07592083 0,13248704 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,07592083 0,13238659 ! ribosome assembly GO:0042255 13 11 0,000 0,07592083 0,1322863 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,07592083 0,13218616 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,07592083 0,13208617 ! chromatin silencing GO:0006342 19 11 0,000 0,07592083 0,13198633 ! nucleosome positioning GO:0016584 13 11 0,000 0,07592083 0,13188664 ! T cell homeostasis GO:0043029 20 11 0,000 0,07592083 0,13178711 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07592083 0,13168772 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07592083 0,13158848 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07592083 0,13148939 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07592083 0,13139046 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07592083 0,13129167 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07592083 0,13119302 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07592083 0,13109453 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07592083 0,13099619 ! male genitalia development GO:0030539 13 11 0,000 0,07592083 0,13089799 ! cholesterol efflux GO:0033344 19 11 0,000 0,07592083 0,13079994 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,07592083 0,13070203 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07592083 0,13060428 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07592083 0,13050666 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,07592083 0,1304092 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,07592083 0,13031188 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07592083 0,1302147 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,07592083 0,13011767 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,07592083 0,13002079 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07592083 0,12992404 ! lysogeny GO:0030069 18 11 0,000 0,07592083 0,12982745 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,07592083 0,12973099 ! acrosome reaction GO:0007340 13 11 0,000 0,07592083 0,12963468 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07592083 0,12953851 ! negative regulation of cell size GO:0045792 108 64 1,000 0,07677502 0,13089885 ! appendage morphogenesis GO:0035107 93 64 1,000 0,07677502 0,13080188 GO:0035108|limb morphogenesis, ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,07677502 0,13070507 ! appendage development GO:0048736 94 65 1,000 0,07885377 0,13414473 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 1,000 0,07885377 0,13404559 ! protein oligomerization GO:0051259 100 65 1,000 0,07885377 0,13394659 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,0809501 0,13740608 ! regulation of immune effector process GO:0002697 101 66 1,000 0,0809501 0,13730474 ! lactation GO:0007595 20 12 0,000 0,08253235 0,13988535 ! reproductive cellular process GO:0048610 14 12 0,000 0,08253235 0,13978234 ! tRNA modification GO:0006400 14 12 0,000 0,08253235 0,13967948 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08253235 0,13957678 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08253235 0,13947422 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,08253235 0,13937182 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08253235 0,13926956 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08253235 0,13916746 ! non-recombinational repair GO:0000726 19 12 0,000 0,08253235 0,13906551 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08253235 0,1389637 ! peroxisomal transport GO:0043574 21 12 0,000 0,08253235 0,13886205 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,08253235 0,13876054 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08253235 0,13865918 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08253235 0,13855797 ! heart looping GO:0001947 15 12 0,000 0,08253235 0,1384569 ! palate development GO:0060021 15 12 0,000 0,08253235 0,13835599 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08253235 0,13825522 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,08253235 0,1381546 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08253235 0,13805412 ! arginine metabolic process GO:0006525 13 12 0,000 0,08253235 0,13795379 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08253235 0,13785361 ! methionine metabolic process GO:0006555 13 12 0,000 0,08253235 0,13775357 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08253235 0,13765367 ! Golgi organization GO:0007030 18 12 0,000 0,08253235 0,13755392 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08253235 0,13745432 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08253235 0,13735486 ! monoamine transport GO:0015844 13 12 0,000 0,08253235 0,13725554 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08253235 0,13715637 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,08253235 0,13705734 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08253235 0,13695845 ! L-amino acid transport GO:0015807 20 12 0,000 0,08253235 0,13685971 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08253235 0,13676111 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08253235 0,13666265 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08253235 0,13656433 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08253235 0,13646615 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08253235 0,13636811 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08253235 0,13627022 ! cerebellum development GO:0021549 13 12 0,000 0,08253235 0,13617246 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08253235 0,13607485 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08253235 0,13597738 ! histone methylation GO:0016571 15 12 0,000 0,08253235 0,13588004 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08253235 0,13578284 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08253235 0,13568579 ! response to gamma radiation GO:0010332 20 12 0,000 0,08253235 0,13558887 ! intestinal absorption GO:0050892 19 12 0,000 0,08253235 0,13549209 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08253235 0,13539545 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08253235 0,13529894 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08253235 0,13520258 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08253235 0,13510635 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08253235 0,13501025 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08253235 0,1349143 ! response to cold GO:0009409 14 12 0,000 0,08253235 0,13481848 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,08306365 0,13559005 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,08519406 0,13896903 ! rhythmic process GO:0048511 105 68 1,000 0,08519406 0,13887054 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,087341 0,14226933 ! response to drug GO:0042493 108 69 1,000 0,087341 0,14216865 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,08909695 0,14492432 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,08909695 0,1448219 ! cGMP metabolic process GO:0046068 16 13 0,000 0,08909695 0,14471962 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,08909695 0,14461749 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,08909695 0,1445155 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,08909695 0,14441366 ! lipid localization GO:0010876 24 13 0,000 0,08909695 0,14431196 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,08909695 0,1442104 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,08909695 0,14410899 ! organelle fusion GO:0048284 28 13 0,000 0,08909695 0,14400772 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,08909695 0,14390659 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,08909695 0,1438056 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,08909695 0,14370476 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,08909695 0,14360405 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,08909695 0,14350349 ! response to hexose stimulus GO:0009746 19 13 0,000 0,08909695 0,14340307 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,08909695 0,14330278 ! glutamate metabolic process GO:0006536 18 13 0,000 0,08909695 0,14320264 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,08909695 0,14310264 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,08909695 0,14300278 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,08909695 0,14290306 ! NAD metabolic process GO:0019674 21 13 0,000 0,08909695 0,14280347 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,08909695 0,14270403 ! bone mineralization GO:0030282 15 13 0,000 0,08909695 0,14260472 ! regulation of exocytosis GO:0017157 17 13 0,000 0,08909695 0,14250555 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,08909695 0,14240652 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,08909695 0,14230763 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,08909695 0,14220887 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,08909695 0,14211025 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,08909695 0,14201177 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,08909695 0,14191342 ! regulation of cellular pH GO:0030641 20 13 0,000 0,08909695 0,14181521 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,08909695 0,14171714 ! cellular pigmentation GO:0033059 24 13 0,000 0,08909695 0,1416192 ! cofactor transport GO:0051181 19 13 0,000 0,08909695 0,1415214 ! NADP metabolic process GO:0006739 18 13 0,000 0,08909695 0,14142373 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,08909695 0,14132619 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,08909695 0,1412288 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08909695 0,14113153 ! gas transport GO:0015669 18 13 0,000 0,08909695 0,1410344 ! heme biosynthetic process GO:0006783 20 13 0,000 0,08909695 0,1409374 ! regulation of axon extension GO:0030516 23 13 0,000 0,08909695 0,14084054 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,08909695 0,14074381 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,08909695 0,14064721 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,08909695 0,14055074 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,08909695 0,14045441 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,08909695 0,14035821 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,08950412 0,14090314 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,09168309 0,14423469 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,09168309 0,1441361 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,09387758 0,14748527 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,09561495 0,1501122 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,09561495 0,1500098 ! superoxide anion generation GO:0042554 18 14 0,000 0,09561495 0,14990755 ! regulation of S phase GO:0033261 18 14 0,000 0,09561495 0,14980543 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09561495 0,14970345 ! myotube differentiation GO:0014902 21 14 0,000 0,09561495 0,14960161 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09561495 0,14949991 ! inositol metabolic process GO:0006020 20 14 0,000 0,09561495 0,14939835 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09561495 0,14929693 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09561495 0,14919564 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09561495 0,14909449 ! gene silencing by RNA GO:0031047 20 14 0,000 0,09561495 0,14899348 ! response to cAMP GO:0051591 19 14 0,000 0,09561495 0,1488926 ! limbic system development GO:0021761 25 14 0,000 0,09561495 0,14879186 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,09561495 0,14869126 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09561495 0,14859079 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,09561495 0,14849046 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09561495 0,14839027 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,09561495 0,1482902 ! glycine metabolic process GO:0006544 22 14 0,000 0,09561495 0,14819028 ! pituitary gland development GO:0021983 23 14 0,000 0,09561495 0,14809049 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,09561495 0,14799083 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,09561495 0,14789131 ! regulation of heart rate GO:0002027 23 14 0,000 0,09561495 0,14779192 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09561495 0,14769266 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09561495 0,14759354 ! embryo implantation GO:0007566 27 14 0,000 0,09561495 0,14749455 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,09561495 0,14739569 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,09561495 0,14729697 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09561495 0,14719838 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09561495 0,14709992 ! axon cargo transport GO:0008088 27 14 0,000 0,09561495 0,14700159 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09561495 0,14690339 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,09561495 0,14680532 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09561495 0,14670739 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09561495 0,14660958 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09561495 0,14651191 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09561495 0,14641436 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09561495 0,14631695 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09561495 0,14621966 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09561495 0,14612251 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,09561495 0,14602548 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,09561495 0,14592858 ! muscle maintenance GO:0046716 19 14 0,000 0,09561495 0,14583181 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09561495 0,14573517 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,09561495 0,14563866 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09561495 0,14554227 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,09561495 0,14544601 ! cilium assembly GO:0042384 20 14 0,000 0,09561495 0,14534988 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09561495 0,14525388 ! digestion GO:0007586 97 74 1,000 0,09831178 0,14925221 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,09831178 0,14915376 ! negative regulation of growth GO:0045926 123 75 1,000 0,10055086 0,15245021 ! metencephalon development GO:0022037 19 15 0,000 0,10208667 0,15467678 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10208667 0,15457495 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10208667 0,15447325 ! skin development GO:0043588 25 15 0,000 0,10208667 0,15437169 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10208667 0,15427027 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,10208667 0,15416897 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,10208667 0,15406781 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10208667 0,15396678 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10208667 0,15386589 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10208667 0,15376513 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10208667 0,15366449 ! adult walking behavior GO:0007628 25 15 0,000 0,10208667 0,15356399 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10208667 0,15346363 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10208667 0,15336339 ! myoblast differentiation GO:0045445 27 15 0,000 0,10208667 0,15326328 ! centrosome cycle GO:0007098 16 15 0,000 0,10208667 0,15316331 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10208667 0,15306346 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,10208667 0,15296374 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10208667 0,15286416 ! cerebral cortex development GO:0021987 29 15 0,000 0,10208667 0,1527647 ! response to osmotic stress GO:0006970 22 15 0,000 0,10208667 0,15266537 ! vesicle coating GO:0006901 25 15 0,000 0,10208667 0,15256618 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,10208667 0,15246711 ! DNA integration GO:0015074 22 15 0,000 0,10208667 0,15236817 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,10208667 0,15226936 ! peptide secretion GO:0002790 27 15 0,000 0,10208667 0,15217067 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10208667 0,15207212 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10208667 0,15197369 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10208667 0,15187539 ! neuron recognition GO:0008038 22 15 0,000 0,10208667 0,15177721 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,10208667 0,15167916 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10208667 0,15158124 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,10208667 0,15148345 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10208667 0,15138578 ! biomineral formation GO:0031214 18 15 0,000 0,10208667 0,15128824 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10208667 0,15119082 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10208667 0,15109353 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10208667 0,15099636 ! organic cation transport GO:0015695 19 15 0,000 0,10208667 0,15089932 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10208667 0,15080241 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,10208667 0,15070561 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,10208667 0,15060895 ! peptide hormone processing GO:0016486 19 15 0,000 0,10208667 0,1505124 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,10208667 0,15041598 ! amine biosynthetic process GO:0009309 97 76 1,000 0,10280415 0,15137615 ! tRNA metabolic process GO:0006399 95 76 1,000 0,10280415 0,1512793 ! regulation of protein transport GO:0051223 114 76 1,000 0,10280415 0,15118258 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 1,000 0,10507136 0,15441797 ! gland development GO:0048732 148 77 1,000 0,10507136 0,15431936 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,10507136 0,15422088 ! positive regulation of protein modification process GO:0031401 107 78 1,000 0,10735216 0,15746809 ! protein secretion GO:0009306 27 16 0,000 0,10851246 0,15906861 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,10851246 0,15896729 ! hormone secretion GO:0046879 25 16 0,000 0,10851246 0,1588661 ! bone remodeling GO:0046849 24 16 0,000 0,10851246 0,15876504 ! endothelial cell migration GO:0043542 22 16 0,000 0,10851246 0,15866411 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,10851246 0,15856331 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10851246 0,15846263 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,10851246 0,15836209 ! glial cell development GO:0021782 24 16 0,000 0,10851246 0,15826167 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,10851246 0,15816137 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,10851246 0,15806121 ! protein polyubiquitination GO:0000209 26 16 0,000 0,10851246 0,15796117 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,10851246 0,15786126 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,10851246 0,15776147 ! fructose metabolic process GO:0006000 20 16 0,000 0,10851246 0,15766181 ! regulation of protein binding GO:0043393 27 16 0,000 0,10851246 0,15756228 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,10851246 0,15746287 ! protein export from nucleus GO:0006611 24 16 0,000 0,10851246 0,15736359 ! DNA replication initiation GO:0006270 25 16 0,000 0,10851246 0,15726443 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,10851246 0,1571654 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,10851246 0,15706649 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,10851246 0,1569677 ! diencephalon development GO:0021536 25 16 0,000 0,10851246 0,15686904 ! oogenesis GO:0048477 23 16 0,000 0,10851246 0,15677051 ! G1 phase GO:0051318 27 16 0,000 0,10851246 0,1566721 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,10851246 0,15657381 GO:0006626|protein targeting to mitochondrion, ! steroid catabolic process GO:0006706 22 16 0,000 0,10851246 0,15647564 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,10851246 0,1563776 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,10851246 0,15627968 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,10851246 0,15618188 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,10851246 0,15608421 ! sperm-egg recognition GO:0035036 16 16 0,000 0,10851246 0,15598666 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,10851246 0,15588923 ! nerve development GO:0021675 18 16 0,000 0,10851246 0,15579192 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,10851246 0,15569473 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,10851246 0,15559766 ! T cell activation GO:0042110 134 79 1,000 0,10964625 0,15712547 ! ATP biosynthetic process GO:0006754 118 79 1,000 0,10964625 0,15702763 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,11427311 0,16355206 ! regulation of neurological system process GO:0031644 122 81 1,000 0,11427311 0,16345035 ! vitamin metabolic process GO:0006766 103 81 1,000 0,11427311 0,16334876 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,11489262 0,16413231 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,11489262 0,16403043 ! negative regulation of defense response GO:0031348 19 17 0,000 0,11489262 0,16392868 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,11489262 0,16382705 ! glycerol metabolic process GO:0006071 20 17 0,000 0,11489262 0,16372554 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,11489262 0,16362416 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,11489262 0,16352291 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,11489262 0,16342179 ! signal complex assembly GO:0007172 29 17 0,000 0,11489262 0,16332078 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,11489262 0,16321991 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,11489262 0,16311915 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,11489262 0,16301852 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,11489262 0,16291802 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,11489262 0,16281764 ! memory GO:0007613 25 17 0,000 0,11489262 0,16271738 ! keratinization GO:0031424 17 17 0,000 0,11489262 0,16261725 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,11489262 0,16251724 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,11489262 0,16241735 ! regulation of viral genome replication GO:0045069 24 17 0,000 0,11489262 0,16231758 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,11489262 0,16221794 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,11489262 0,16211842 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,11489262 0,16201902 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,11489262 0,16191975 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,11489262 0,16182059 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,11489262 0,16172156 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,11489262 0,16162265 ! membrane budding GO:0006900 29 17 0,000 0,11489262 0,16152385 ! heme metabolic process GO:0042168 27 17 0,000 0,11489262 0,16142518 ! actin filament bundle formation GO:0051017 26 17 0,000 0,11489262 0,16132663 ! neuromuscular junction development GO:0007528 23 17 0,000 0,11489262 0,1612282 ! body fluid secretion GO:0007589 27 17 0,000 0,11489262 0,16112989 ! stem cell differentiation GO:0048863 36 17 0,000 0,11489262 0,1610317 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,11489262 0,16093363 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,11489262 0,16083568 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,11489262 0,16073785 ! sensory perception of pain GO:0019233 23 17 0,000 0,11489262 0,16064014 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,11489262 0,16054254 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,11489262 0,16044507 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,11489262 0,16034771 ! synaptogenesis GO:0007416 24 17 0,000 0,11489262 0,16025047 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,11489262 0,16015335 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,11489262 0,16005635 GO:0046467|membrane lipid biosynthetic process, ! cell-cell junction organization GO:0045216 25 17 0,000 0,11489262 0,15995946 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,11489262 0,15986269 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,11489262 0,15976604 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,11489262 0,1596695 ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,11894955 0,16520771 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,12122749 0,1682699 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,12122749 0,16816841 ! positive regulation of translation GO:0045727 28 18 0,000 0,12122749 0,16806704 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,12122749 0,16796579 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,12122749 0,16786467 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12122749 0,16776367 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,12122749 0,16766279 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12122749 0,16756203 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12122749 0,16746139 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12122749 0,16736087 ! axis specification GO:0009798 26 18 0,000 0,12122749 0,16726048 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,12122749 0,1671602 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12122749 0,16706005 ! pancreas development GO:0031016 26 18 0,000 0,12122749 0,16696001 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,12122749 0,16686009 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12122749 0,1667603 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12122749 0,16666062 ! pigmentation during development GO:0048066 31 18 0,000 0,12122749 0,16656106 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12122749 0,16646162 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,12122749 0,1663623 ! fucose metabolic process GO:0006004 26 18 0,000 0,12122749 0,1662631 ! response to fungus GO:0009620 19 18 0,000 0,12122749 0,16616401 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12122749 0,16606505 ! heart process GO:0003015 27 18 0,000 0,12122749 0,1659662 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12122749 0,16586747 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,12122749 0,16576886 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12122749 0,16567036 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12122749 0,16557198 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,12122749 0,16547372 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12122749 0,16537557 ! hormone transport GO:0009914 27 18 0,000 0,12122749 0,16527754 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,12122749 0,16517963 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12122749 0,16508183 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12122749 0,16498415 ! cell-cell recognition GO:0009988 20 18 0,000 0,12122749 0,16488659 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,12122749 0,16478914 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12122749 0,1646918 ! regulation of glucose import GO:0046324 21 18 0,000 0,12122749 0,16459458 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,12122749 0,16449747 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,12122749 0,16440048 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,12367325 0,16761843 ! regulation of protein localization GO:0032880 132 85 1,000 0,12367325 0,16751972 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,12367325 0,16742112 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,12605212 0,1705411 ! cell cycle arrest GO:0007050 150 86 1,000 0,12605212 0,17044084 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,12605212 0,1703407 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,12751737 0,17221959 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,12751737 0,17211852 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,12751737 0,17201757 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,12751737 0,17191674 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,12751737 0,17181602 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,12751737 0,17171543 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,12751737 0,17161495 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,12751737 0,17151459 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,12751737 0,17141435 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,12751737 0,17131423 ! response to alkaloid GO:0043279 32 19 0,000 0,12751737 0,17121422 ! sensory perception of taste GO:0050909 23 19 0,000 0,12751737 0,17111433 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,12751737 0,17101455 ! smooth muscle contraction GO:0006939 36 19 0,000 0,12751737 0,17091489 ! peroxisome organization GO:0007031 29 19 0,000 0,12751737 0,17081535 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,12751737 0,17071592 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,12751737 0,17061661 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,12751737 0,17051741 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,12751737 0,17041833 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,12751737 0,17031937 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,12751737 0,17022052 ! sex determination GO:0007530 29 19 0,000 0,12751737 0,17012178 ! plasma membrane fusion GO:0045026 23 19 0,000 0,12751737 0,17002316 ! cytolysis GO:0019835 20 19 0,000 0,12751737 0,16992465 ! renal system process GO:0003014 35 19 0,000 0,12751737 0,16982626 ! vasodilation GO:0042311 33 19 0,000 0,12751737 0,16972798 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,12751737 0,16962982 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,12751737 0,16953177 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,12751737 0,16943383 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,12751737 0,169336 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,12751737 0,16923829 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,12751737 0,16914069 ! sarcomere organization GO:0045214 23 19 0,000 0,12751737 0,1690432 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,12751737 0,16894583 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,12751737 0,16884856 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,12751737 0,16875141 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,12751737 0,16865437 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,12751737 0,16855744 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,12751737 0,16846063 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,12751737 0,16836392 ! protein stabilization GO:0050821 26 19 0,000 0,12751737 0,16826733 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 1,000 0,12844195 0,16939018 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,12844195 0,16929311 GO:0060538|skeletal muscle organ development, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 1,000 0,13084247 0,17235835 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,13084247 0,17225969 ! interphase GO:0051325 159 88 1,000 0,13084247 0,17216115 ! establishment of RNA localization GO:0051236 128 88 1,000 0,13084247 0,17206271 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 1,000 0,13325342 0,17513306 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,13325342 0,17503304 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,13376259 0,17560158 ! iron ion transport GO:0006826 37 20 0,000 0,13376259 0,17550141 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,13376259 0,17540135 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,13376259 0,17530141 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,13376259 0,17520158 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,13376259 0,17510186 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,13376259 0,17500226 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,13376259 0,17490277 ! spinal cord development GO:0021510 31 20 0,000 0,13376259 0,17480339 ! response to ethanol GO:0045471 37 20 0,000 0,13376259 0,17470413 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,13376259 0,17460498 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,13376259 0,17450594 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,13376259 0,17440701 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,13376259 0,1743082 ! chromosome condensation GO:0030261 31 20 0,000 0,13376259 0,17420949 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,13376259 0,1741109 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,13376259 0,17401242 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,13376259 0,17391406 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,13376259 0,1738158 ! pallium development GO:0021543 38 20 0,000 0,13376259 0,17371765 ! DNA modification GO:0006304 28 20 0,000 0,13376259 0,17361962 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,13376259 0,1735217 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,13376259 0,17342388 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,13376259 0,17332618 ! collagen catabolic process GO:0030574 25 20 0,000 0,13376259 0,17322858 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,13376259 0,1731311 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,13376259 0,17303373 ! alditol metabolic process GO:0019400 24 20 0,000 0,13376259 0,17293646 ! actin filament-based movement GO:0030048 34 20 0,000 0,13376259 0,17283931 ! hormone metabolic process GO:0042445 121 90 1,000 0,13567452 0,17521134 ! RNA localization GO:0006403 135 91 1,000 0,13810551 0,17825065 ! ATP metabolic process GO:0046034 137 91 1,000 0,13810551 0,17815068 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,13996347 0,18044618 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,13996347 0,18034509 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,13996347 0,18024411 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,13996347 0,18014324 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,13996347 0,18004249 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,13996347 0,17994186 GO:0009799|determination of symmetry, ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,13996347 0,17984133 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,13996347 0,17974091 ! vesicle docking GO:0048278 27 21 0,000 0,13996347 0,17964061 ! phototransduction GO:0007602 25 21 0,000 0,13996347 0,17954042 ! dendrite development GO:0016358 35 21 0,000 0,13996347 0,17944034 ! visual behavior GO:0007632 39 21 0,000 0,13996347 0,17934038 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,13996347 0,17924052 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,13996347 0,17914078 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,13996347 0,17904114 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,13996347 0,17894162 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,13996347 0,17884221 ! cell aging GO:0007569 32 21 0,000 0,13996347 0,17874291 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,13996347 0,17864372 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,13996347 0,17854464 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,13996347 0,17844566 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,13996347 0,1783468 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,13996347 0,17824805 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,13996347 0,17814941 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,13996347 0,17805087 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,13996347 0,17795245 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,13996347 0,17785413 ! fatty acid transport GO:0015908 30 21 0,000 0,13996347 0,17775592 ! immunoglobulin production GO:0002377 33 21 0,000 0,13996347 0,17765782 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,13996347 0,17755983 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,13996347 0,17746195 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,13996347 0,17736418 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,13996347 0,17726651 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,13996347 0,17716895 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,13996347 0,1770715 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,13996347 0,17697415 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,13996347 0,17687691 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,13996347 0,17677978 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,13996347 0,17668275 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,14054612 0,17732094 ! cell fate commitment GO:0045165 141 92 1,000 0,14054612 0,17722373 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,1429961 0,18021427 ! response to oxidative stress GO:0006979 141 94 1,000 0,1454552 0,18321301 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,14612031 0,18395003 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,14612031 0,1838494 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,14612031 0,18374888 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,14612031 0,18364847 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,14612031 0,18354817 ! leukocyte adhesion GO:0007159 38 22 0,000 0,14612031 0,18344798 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,14612031 0,1833479 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,14612031 0,18324793 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,14612031 0,18314807 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,14612031 0,18304832 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,14612031 0,18294867 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,14612031 0,18284913 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,14612031 0,18274971 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,14612031 0,18265038 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,14612031 0,18255117 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,14612031 0,18245207 ! membrane depolarization GO:0051899 35 22 0,000 0,14612031 0,18235307 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,14612031 0,18225418 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,14612031 0,1821554 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,14612031 0,18205672 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,14612031 0,18195815 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,14612031 0,18185969 ! blastocyst development GO:0001824 37 22 0,000 0,14612031 0,18176133 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,14612031 0,18166309 ! protein tetramerization GO:0051262 39 22 0,000 0,14612031 0,18156494 ! regulation of binding GO:0051098 151 95 1,000 0,14792315 0,18370586 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,15039972 0,18668071 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,15223342 0,18885484 ! neuron fate commitment GO:0048663 32 23 0,000 0,15223342 0,18875303 ! embryonic pattern specification GO:0009880 31 23 0,000 0,15223342 0,18865133 ! myelination GO:0042552 35 23 0,000 0,15223342 0,18854974 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,15223342 0,18844826 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,15223342 0,18834689 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,15223342 0,18824563 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,15223342 0,18814448 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,15223342 0,18804343 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,15223342 0,1879425 ! vesicle targeting GO:0006903 32 23 0,000 0,15223342 0,18784167 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,15223342 0,18774095 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,15223342 0,18764034 ! osteoblast differentiation GO:0001649 40 23 0,000 0,15223342 0,18753983 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,15223342 0,18743944 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,15223342 0,18733915 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,15223342 0,18723897 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,15223342 0,18713889 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,15223342 0,18703893 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,15223342 0,18693907 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,15223342 0,18683931 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,15223342 0,18673966 ! cell fate determination GO:0001709 45 23 0,000 0,15223342 0,18664012 ! pentose metabolic process GO:0019321 31 23 0,000 0,15223342 0,18654069 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,15223342 0,18644136 ! spermatid development GO:0007286 33 23 0,000 0,15223342 0,18634213 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,15223342 0,18624302 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,15223342 0,186144 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,15223342 0,1860451 ! telomere organization GO:0032200 32 23 0,000 0,15223342 0,18594629 GO:0000723|telomere maintenance, ! regulation of amine transport GO:0051952 38 23 0,000 0,15223342 0,1858476 ! extracellular structure organization GO:0043062 156 99 1,000 0,15787863 0,19263705 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,15830312 0,19305258 ! initiation of viral infection GO:0019059 42 24 0,000 0,15830312 0,19295028 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,15830312 0,19284808 ! superoxide metabolic process GO:0006801 32 24 0,000 0,15830312 0,19274599 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,15830312 0,19264401 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,15830312 0,19254213 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,15830312 0,19244036 ! sperm motility GO:0030317 27 24 0,000 0,15830312 0,19233871 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,15830312 0,19223715 ! vacuole organization GO:0007033 39 24 0,000 0,15830312 0,19213571 ! receptor metabolic process GO:0043112 37 24 0,000 0,15830312 0,19203437 ! response to toxin GO:0009636 38 24 0,000 0,15830312 0,19193314 ! negative regulation of cell development GO:0010721 56 24 0,000 0,15830312 0,19183202 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,15830312 0,191731 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,15830312 0,19163009 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,15830312 0,19152928 ! glutathione metabolic process GO:0006749 29 24 0,000 0,15830312 0,19142859 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,15830312 0,19132799 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,15830312 0,19122751 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,1603872 0,19364334 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 1,000 0,1603872 0,19354174 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,1643297 0,19819524 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,1643297 0,19809136 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,1643297 0,19798759 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,1643297 0,19788393 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,1643297 0,19778038 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,1643297 0,19767694 ! peptide transport GO:0015833 43 25 0,000 0,1643297 0,19757361 ! male gonad development GO:0008584 33 25 0,000 0,1643297 0,19747038 ! iron ion homeostasis GO:0055072 39 25 0,000 0,1643297 0,19736727 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,1643297 0,19726426 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,1643297 0,19716135 ! phospholipid transport GO:0015914 35 25 0,000 0,1643297 0,19705856 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,1643297 0,19695587 ! detection of light stimulus GO:0009583 30 25 0,000 0,1643297 0,19685329 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,1643297 0,19675081 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,1643297 0,19664845 ! leukocyte proliferation GO:0070661 39 25 0,000 0,1643297 0,19654619 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,1643297 0,19644403 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,17031348 0,20349143 ! translational initiation GO:0006413 43 26 0,000 0,17031348 0,20338577 ! regulation of pH GO:0006885 36 26 0,000 0,17031348 0,20328023 ! circadian rhythm GO:0007623 42 26 0,000 0,17031348 0,20317479 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,17031348 0,20306947 ! post-embryonic development GO:0009791 42 26 0,000 0,17031348 0,20296425 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,17031348 0,20285914 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,17031348 0,20275414 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,17031348 0,20264925 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,17031348 0,20254447 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,17031348 0,20243979 ! regulation of coagulation GO:0050818 39 26 0,000 0,17031348 0,20233523 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,17625475 0,20928545 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,17625475 0,20917746 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,17625475 0,20906958 ! membrane docking GO:0022406 39 27 0,000 0,17625475 0,20896182 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,17625475 0,20885416 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,17625475 0,20874661 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,17625475 0,20863918 ! myofibril assembly GO:0030239 36 27 0,000 0,17625475 0,20853185 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,17625475 0,20842464 ! response to ionizing radiation GO:0010212 47 27 0,000 0,17625475 0,20831753 ! natural killer cell activation GO:0030101 35 27 0,000 0,17625475 0,20821054 ! lipid oxidation GO:0034440 38 27 0,000 0,17625475 0,20810366 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,17625475 0,20799688 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,17625475 0,20789022 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,17625475 0,20778366 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,17625475 0,20767721 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,17625475 0,20757088 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,17625475 0,20746465 ! gene silencing GO:0016458 41 27 0,000 0,17625475 0,20735853 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,18215381 0,21418904 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,18215381 0,2140796 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,18215381 0,21397026 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,18215381 0,21386104 ! cell junction assembly GO:0034329 56 28 0,000 0,18215381 0,21375192 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,18215381 0,21364292 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,18215381 0,21353403 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,18215381 0,21342525 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,18215381 0,21331658 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,18215381 0,21320802 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,18215381 0,21309958 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,18215381 0,21299124 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,18215381 0,21288301 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,18215381 0,2127749 ! mesoderm formation GO:0001707 46 28 0,000 0,18215381 0,21266689 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,18215381 0,21255899 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,18215381 0,2124512 ! ensheathment of neurons GO:0007272 43 28 0,000 0,18215381 0,21234352 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,18215381 0,21223595 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,18215381 0,21212849 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,18215381 0,21202114 ! regulation of B cell activation GO:0050864 42 28 0,000 0,18215381 0,21191389 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,18801097 0,2186174 ! regulation of innate immune response GO:0045088 38 29 0,000 0,18801097 0,21850693 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,18801097 0,21839658 ! protein targeting to membrane GO:0006612 53 29 0,000 0,18801097 0,21828633 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,18801097 0,2181762 ! mismatch repair GO:0006298 34 29 0,000 0,18801097 0,21806617 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,18801097 0,21795626 ! muscle cell development GO:0055001 38 29 0,000 0,18801097 0,21784646 ! formation of primary germ layer GO:0001704 48 29 0,000 0,18801097 0,21773677 ! telencephalon development GO:0021537 52 29 0,000 0,18801097 0,21762719 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,18801097 0,21751772 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,19382651 0,22413322 ! collagen metabolic process GO:0032963 40 30 0,000 0,19382651 0,22402059 ! organic anion transport GO:0015711 51 30 0,000 0,19382651 0,22390807 ! cholesterol transport GO:0030301 46 30 0,000 0,19382651 0,22379567 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,19382651 0,22368338 ! spliceosome assembly GO:0000245 49 30 0,000 0,19382651 0,2235712 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,19382651 0,22345913 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,19382651 0,22334718 ! ceramide metabolic process GO:0006672 43 30 0,000 0,19382651 0,22323534 ! hindbrain development GO:0030902 45 30 0,000 0,19382651 0,22312361 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,19382651 0,22301199 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,19382651 0,22290048 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,19382651 0,22278909 ! response to heat GO:0009408 41 30 0,000 0,19382651 0,22267781 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,19382651 0,22256663 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,19382651 0,22245557 ! negative regulation of secretion GO:0051048 49 31 0,000 0,19960073 0,22896842 ! mammary gland development GO:0030879 57 31 0,000 0,19960073 0,22885427 ! glial cell differentiation GO:0010001 55 31 0,000 0,19960073 0,22874025 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,19960073 0,22862633 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,19960073 0,22851253 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,19960073 0,22839884 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,19960073 0,22828527 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,19960073 0,22817181 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,19960073 0,22805846 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,19960073 0,22794522 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,19960073 0,2278321 ! cell fate specification GO:0001708 37 31 0,000 0,19960073 0,22771908 ! regulation of muscle development GO:0048634 48 32 0,000 0,20533392 0,23414378 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,20533392 0,23402776 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,20533392 0,23391184 ! meiosis I GO:0007127 52 32 0,000 0,20533392 0,23379605 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,20533392 0,23368036 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,20533392 0,23356479 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,20533392 0,23344934 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,20533392 0,233334 ! peripheral nervous system development GO:0007422 53 32 0,000 0,20533392 0,23321877 ! regulation of protein stability GO:0031647 48 32 0,000 0,20533392 0,23310366 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,20533392 0,23298866 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,20533392 0,23287377 ! cytokine production GO:0001816 44 32 0,000 0,20533392 0,232759 ! vesicle localization GO:0051648 47 32 0,000 0,20533392 0,23264434 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,21102637 0,23897619 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,21102637 0,23885859 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,21102637 0,2387411 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,21102637 0,23862372 ! ear morphogenesis GO:0042471 42 33 0,000 0,21102637 0,23850646 ! cell junction organization GO:0034330 63 33 0,000 0,21102637 0,23838932 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,21102637 0,23827229 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,21102637 0,23815537 ! nucleus organization GO:0006997 49 33 0,000 0,21102637 0,23803857 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,21102637 0,23792189 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,21102637 0,23780531 ! lipid homeostasis GO:0055088 55 33 0,000 0,21102637 0,23768886 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,21102637 0,23757251 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,21102637 0,23745629 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,21102637 0,23734017 ! cytokinesis GO:0000910 52 33 0,000 0,21102637 0,23722417 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,21102637 0,23710828 ! mRNA catabolic process GO:0006402 48 34 0,000 0,21667837 0,24333996 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,21667837 0,2432212 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,21667837 0,24310256 ! feeding behavior GO:0007631 45 34 0,000 0,21667837 0,24298403 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,21667837 0,24286561 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,21667837 0,24274732 ! neuron migration GO:0001764 46 34 0,000 0,21667837 0,24262913 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,21667837 0,24251107 ! female gamete generation GO:0007292 43 34 0,000 0,21667837 0,24239311 ! polyol metabolic process GO:0019751 44 34 0,000 0,21667837 0,24227528 ! aerobic respiration GO:0009060 47 34 0,000 0,21667837 0,24215755 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,21667837 0,24203994 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,2222902 0,24818808 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,2222902 0,24806766 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,2222902 0,24794736 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,2222902 0,24782717 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,2222902 0,2477071 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,2222902 0,24758714 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,2222902 0,2474673 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,2222902 0,24734758 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,2222902 0,24722797 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,2222902 0,24710848 ! glycogen metabolic process GO:0005977 48 35 0,000 0,2222902 0,24698911 ! pigment metabolic process GO:0042440 61 35 0,000 0,2222902 0,24686985 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,2222902 0,2467507 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,22786214 0,25281376 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,22786214 0,25269186 ! negative regulation of binding GO:0051100 58 36 0,000 0,22786214 0,25257008 ! organic ether metabolic process GO:0018904 46 36 0,000 0,22786214 0,25244842 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,22786214 0,25232688 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,22786214 0,25220545 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,22786214 0,25208414 ! glucan metabolic process GO:0044042 49 36 0,000 0,22786214 0,25196294 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,23339448 0,25795642 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,23339448 0,25783252 ! learning GO:0007612 67 37 0,000 0,23339448 0,25770874 ! ion transmembrane transport GO:0034220 56 37 0,000 0,23339448 0,25758508 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,23339448 0,25746154 ! amino acid activation GO:0043038 52 37 0,000 0,23339448 0,25733812 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,23339448 0,25721481 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,2388875 0,26314236 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,2388875 0,2630164 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,2388875 0,26289055 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,2388875 0,26276483 ! phagocytosis GO:0006909 60 38 0,000 0,2388875 0,26263922 ! pigmentation GO:0043473 74 38 0,000 0,2388875 0,26251374 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,24434147 0,26837888 ! male sex differentiation GO:0046661 53 39 0,000 0,24434147 0,26825078 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,24434147 0,2681228 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,24434147 0,26799494 ! JNK cascade GO:0007254 54 39 0,000 0,24434147 0,2678672 ! synapse organization GO:0050808 55 39 0,000 0,24434147 0,26773958 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,24975667 0,27354302 ! regulation of tube size GO:0035150 60 40 0,000 0,24975667 0,27341282 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,24975667 0,27328275 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,24975667 0,2731528 ! peptide metabolic process GO:0006518 56 40 0,000 0,24975667 0,27302298 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,24975667 0,27289327 ! inner ear development GO:0048839 57 40 0,000 0,24975667 0,27276369 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,24975667 0,27263424 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,24975667 0,2725049 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,24975667 0,27237569 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,24975667 0,27224661 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,24975667 0,27211764 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,25513337 0,27784411 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,25513337 0,27771261 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,25513337 0,27758124 ! glucose transport GO:0015758 52 41 0,000 0,25513337 0,27745 ! endosome transport GO:0016197 71 41 0,000 0,25513337 0,27731888 ! striated muscle contraction GO:0006941 62 41 0,000 0,25513337 0,27718788 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,25513337 0,27705701 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,25513337 0,27692626 ! biopolymer methylation GO:0043414 62 41 0,000 0,25513337 0,27679564 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,25513337 0,27666514 ! mitochondrial transport GO:0006839 60 42 0,000 0,26047184 0,28232104 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,26047184 0,28218806 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,26047184 0,2820552 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,26047184 0,28192247 ! cellular component disassembly GO:0022411 64 42 0,000 0,26047184 0,28178986 ! hexose transport GO:0008645 54 42 0,000 0,26047184 0,28165738 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,26047184 0,28152502 ! excretion GO:0007588 63 42 0,000 0,26047184 0,28139279 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,26047184 0,28126068 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,26047184 0,28112869 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,26047184 0,28099683 ! activation of caspase activity GO:0006919 65 43 0,000 0,26577236 0,28658061 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,26577236 0,28644631 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,26577236 0,28631215 ! vesicle organization GO:0016050 79 43 0,000 0,26577236 0,2861781 ! methylation GO:0032259 64 43 0,000 0,26577236 0,28604419 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,27103519 0,291572 ! glycolysis GO:0006096 53 44 0,000 0,27103519 0,29143569 ! regulation of action potential GO:0001508 71 44 0,000 0,27103519 0,2912995 ! regulation of ion transport GO:0043269 57 44 0,000 0,27103519 0,29116344 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,27103519 0,29102751 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,27103519 0,29089171 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,27103519 0,29075603 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,27103519 0,29062048 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,27103519 0,29048506 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,27103519 0,29034976 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,27103519 0,29021459 ! RNA catabolic process GO:0006401 64 45 0,000 0,27626059 0,29567211 ! positive regulation of defense response GO:0031349 59 45 0,000 0,27626059 0,29553459 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,27626059 0,29539719 ! cell recognition GO:0008037 58 45 0,000 0,27626059 0,29525993 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,27626059 0,29512279 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,28144884 0,30052569 ! cell redox homeostasis GO:0045454 63 46 0,000 0,28144884 0,30038623 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,28144884 0,30024691 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,28144884 0,30010771 ! response to UV GO:0009411 75 46 0,000 0,28144884 0,29996864 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,28660019 0,30531747 ! endocrine system development GO:0035270 83 47 0,000 0,28660019 0,30517612 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,28660019 0,3050349 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,28660019 0,30489382 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,28660019 0,30475286 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! chloride transport GO:0006821 67 48 0,000 0,2917149 0,31004818 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,2917149 0,30990497 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 0,000 0,2917149 0,30976189 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,2917149 0,30961895 ! gastrulation GO:0007369 73 48 0,000 0,2917149 0,30947614 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,2917149 0,30933345 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,2917149 0,3091909 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,2917149 0,30904849 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,2917149 0,3089062 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,29679323 0,31413917 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,29679323 0,31399468 ! sensory perception of smell GO:0007608 61 49 0,000 0,29679323 0,31385031 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,29679323 0,31370608 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,29679323 0,31356198 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,29679323 0,31341801 ! germ cell development GO:0007281 68 49 0,000 0,29679323 0,31327417 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,29679323 0,31313047 ! ear development GO:0043583 72 50 0,000 0,30183544 0,31830422 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,30183544 0,31815834 ! membrane fusion GO:0006944 80 50 0,000 0,30183544 0,3180126 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,30183544 0,31786699 ! proton transport GO:0015992 75 50 0,000 0,30183544 0,31772151 ! hydrogen transport GO:0006818 77 51 0,000 0,30684178 0,32284359 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,30684178 0,32269597 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,30684178 0,32254849 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,30684178 0,32240114 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,30684178 0,32225393 ! transition metal ion transport GO:0000041 74 52 0,000 0,31181251 0,32732486 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,31181251 0,32717554 ! aging GO:0007568 79 52 0,000 0,31181251 0,32702634 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,31181251 0,32687729 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,31674788 0,33189983 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,31674788 0,33174869 ! single fertilization GO:0007338 59 53 0,000 0,31674788 0,33159769 ! amino acid transport GO:0006865 84 54 0,000 0,32164813 0,33657448 ! glucose catabolic process GO:0006007 66 54 0,000 0,32164813 0,33642142 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,32164813 0,3362685 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,32164813 0,33611572 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,32164813 0,33596308 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,32164813 0,33581058 ! exocytosis GO:0006887 74 55 0,000 0,32651352 0,34073552 ! mesoderm development GO:0007498 76 55 0,000 0,32651352 0,34058099 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,32651352 0,34042661 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,32651352 0,34027236 ! carbohydrate transport GO:0008643 74 57 0,000 0,33614068 0,35014654 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,33614068 0,34998803 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,33614068 0,34982967 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,34090294 0,3546254 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,34090294 0,35446509 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,34563131 0,35921917 ! activation of MAPK activity GO:0000187 84 59 0,000 0,34563131 0,35905692 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,34563131 0,35889482 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,35032603 0,36360554 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,35032603 0,36344153 ! fertilization GO:0009566 68 60 0,000 0,35032603 0,36327767 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,35498734 0,36794541 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,35498734 0,36777967 ! amine catabolic process GO:0009310 90 62 0,000 0,35961546 0,37240683 ! neurotransmitter transport GO:0006836 81 62 0,000 0,35961546 0,37223923 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,35961546 0,37207178 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,36421065 0,37665669 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,36421065 0,37648741 ! regulation of lipase activity GO:0060191 109 63 0,000 0,36421065 0,37631828 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,36877312 0,38086132 ! hexose catabolic process GO:0019320 82 64 0,000 0,36877312 0,38069038 ! regulation of caspase activity GO:0043281 97 65 0,000 0,37330311 0,38519387 ! defense response to bacterium GO:0042742 73 65 0,000 0,37330311 0,38502114 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,37330311 0,38484856 ! antigen processing and presentation GO:0019882 96 66 0,000 0,37780084 0,38931091 ! axon guidance GO:0007411 99 66 0,000 0,37780084 0,38913656 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,38226656 0,39356002 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,38226656 0,39338393 ! learning or memory GO:0007611 123 68 0,000 0,38670048 0,39776883 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,38670048 0,39759101 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,38670048 0,39741336 ! inorganic anion transport GO:0015698 93 68 0,000 0,38670048 0,39723586 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,39110282 0,40157879 ! amine transport GO:0015837 101 70 0,000 0,39547382 0,40588567 ! muscle cell differentiation GO:0042692 104 71 0,000 0,39981368 0,41015677 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,39981368 0,40997391 ! regulation of peptidase activity GO:0052547 106 72 0,000 0,40412264 0,4142077 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,40412264 0,4140232 ! negative regulation of transport GO:0051051 116 73 0,000 0,40840091 0,41821999 ! regulation of blood pressure GO:0008217 107 73 0,000 0,40840091 0,41803387 ! mitochondrion organization GO:0007005 104 73 0,000 0,40840091 0,41784791 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,40840091 0,41766212 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,41264871 0,42181868 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,41264871 0,42163129 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,41686625 0,4257515 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,42521141 0,43408177 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,42521141 0,43388919 ! protein ubiquitination GO:0016567 125 77 0,000 0,42521141 0,43369678 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,42521141 0,43350454 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,42521141 0,43331247 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,42933945 0,43732539 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,42933945 0,4371318 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,43343808 0,44110955 ! cellular respiration GO:0045333 107 79 0,000 0,43343808 0,44091445 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,43343808 0,44071953 ! regulation of lyase activity GO:0051339 133 79 0,000 0,43343808 0,44052478 ! chromatin assembly GO:0031497 102 80 0,000 0,43750751 0,44446434 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,43750751 0,44426811 ! forebrain development GO:0030900 131 80 0,000 0,43750751 0,44407205 ! mRNA transport GO:0051028 121 81 0,000 0,44154794 0,44797541 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,44154794 0,44777789 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,44954262 0,45568446 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of defense response GO:0031347 117 84 0,000 0,45349729 0,45949064 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,45349729 0,45928831 ! sterol metabolic process GO:0016125 120 84 0,000 0,45349729 0,45908616 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,45742376 0,4628573 ! rRNA metabolic process GO:0016072 107 85 0,000 0,45742376 0,46265376 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 0,000 0,45742376 0,4624504 ! regulation of membrane potential GO:0042391 128 85 0,000 0,45742376 0,46224721 ! nucleosome organization GO:0034728 114 87 0,000 0,46519295 0,46989187 ! cellular defense response GO:0006968 102 87 0,000 0,46519295 0,4696856 ! female pregnancy GO:0007565 130 87 0,000 0,46519295 0,4694795 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,46519295 0,46927359 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,46903606 0,47294298 GO:0016054|organic acid catabolic process, ! regulation of T cell activation GO:0050863 128 89 0,000 0,47285177 0,47658154 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,47664028 0,48018951 ! response to virus GO:0009615 122 91 0,000 0,48040178 0,48376712 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,48413646 0,4873146 ! DNA recombination GO:0006310 146 92 0,000 0,48413646 0,48710142 ! sulfur metabolic process GO:0006790 118 92 0,000 0,48413646 0,48688844 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,4878445 0,49040313 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,4878445 0,49018889 ! electron transport chain GO:0022900 123 94 0,000 0,49152611 0,49367251 ! carboxylic acid transport GO:0046942 147 95 0,000 0,49518146 0,49712674 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,49881074 0,50055179 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,49881074 0,5003335 ! response to light stimulus GO:0009416 153 96 0,000 0,49881074 0,50011539 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,50241414 0,50350872 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,50241414 0,50328943 ! calcium ion transport GO:0006816 167 99 0,000 0,50954401 0,5102095 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,51307085 0,51351738 ! divalent metal ion transport GO:0070838 171 100 0,000 0,51307085 0,51329402 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,51307085 0,51307085