pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/574-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of glycolysis GO:0045821 13 5 2,000 2,494E-07 6,093E-04 ! regulation of DNA metabolic process GO:0051052 188 97 5,000 4,571E-07 5,584E-04 ! regulation of DNA replication GO:0006275 105 56 4,000 6,924E-07 5,639E-04 ! positive regulation of cell migration GO:0030335 137 58 4,000 8,267E-07 5,049E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 3,000 1,022E-06 4,995E-04 ! response to endoplasmic reticulum stress GO:0034976 46 26 3,000 1,022E-06 4,162E-04 ! ER overload response GO:0006983 13 8 2,000 1,388E-06 4,843E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 1,388E-06 4,238E-04 ! peptidyl-tyrosine modification GO:0018212 57 28 3,000 1,394E-06 3,783E-04 ! positive regulation of cell motion GO:0051272 157 65 4,000 1,466E-06 3,582E-04 ! ER-nuclear signaling pathway GO:0006984 52 29 3,000 1,613E-06 3,583E-04 ! positive regulation of glucose metabolic process GO:0010907 18 9 2,000 2,077E-06 4,229E-04 ! regulation of glycolysis GO:0006110 20 9 2,000 2,077E-06 3,903E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 2,000 2,961E-06 5,167E-04 ! protein sumoylation GO:0016925 17 10 2,000 2,961E-06 4,822E-04 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 2,000 2,961E-06 4,521E-04 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 2,961E-06 4,255E-04 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 2,000 4,063E-06 5,514E-04 ! positive regulation of cellular catabolic process GO:0031331 34 12 2,000 5,405E-06 6,95E-04 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 2,000 7,011E-06 8,565E-04 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 8,905E-06 1,036E-03 ! induction of apoptosis by intracellular signals GO:0008629 95 45 3,000 9,758E-06 1,084E-03 ! regulation of gene-specific transcription GO:0032583 102 46 3,000 1,066E-05 1,133E-03 ! regulation of glucose metabolic process GO:0010906 28 16 2,000 1,364E-05 1,388E-03 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 2,000 1,653E-05 1,615E-03 ! response to retinoic acid GO:0032526 31 18 2,000 1,979E-05 1,86E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 2,000 1,979E-05 1,791E-03 ! regulation of angiogenesis GO:0045765 125 54 3,000 2,029E-05 1,771E-03 ! response to vitamin A GO:0033189 32 19 2,000 2,345E-05 1,976E-03 ! response to vitamin GO:0033273 36 20 2,000 2,753E-05 2,242E-03 ! regulation of carbohydrate metabolic process GO:0006109 37 20 2,000 2,753E-05 2,17E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 2,753E-05 2,102E-03 ! negative regulation of translation GO:0017148 32 20 2,000 2,753E-05 2,038E-03 ! DNA damage response, signal transduction GO:0042770 136 62 3,000 3,515E-05 2,526E-03 ! regulation of homeostatic process GO:0032844 148 62 3,000 3,515E-05 2,454E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 2,000 3,703E-05 2,513E-03 ! positive regulation of DNA replication GO:0045740 44 23 2,000 4,249E-05 2,806E-03 ! regulation of cellular catabolic process GO:0031329 55 24 2,000 4,846E-05 3,115E-03 ! lung development GO:0030324 165 69 3,000 5,362E-05 3,359E-03 ! keratinization GO:0031424 37 25 2,000 5,495E-05 3,356E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 2,000 5,495E-05 3,274E-03 ! protein tetramerization GO:0051262 57 25 2,000 5,495E-05 3,196E-03 ! respiratory tube development GO:0030323 171 72 3,000 6,338E-05 3,601E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 6,958E-05 3,863E-03 ! regulation of endothelial cell proliferation GO:0001936 60 27 2,000 6,958E-05 3,778E-03 ! cellular response to oxidative stress GO:0034599 43 27 2,000 6,958E-05 3,695E-03 ! respiratory system development GO:0060541 175 74 3,000 7,056E-05 3,668E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 7,776E-05 3,958E-03 ! hemoglobin biosynthetic process GO:0042541 8 5 1,000 8,594E-05 4,285E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 8,594E-05 4,199E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 8,594E-05 4,117E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 8,594E-05 4,037E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 8,594E-05 3,961E-03 ! valine metabolic process GO:0006573 12 5 1,000 8,594E-05 3,888E-03 ! mRNA transcription GO:0009299 10 5 1,000 8,594E-05 3,817E-03 ! G2/M transition checkpoint GO:0031576 8 5 1,000 8,594E-05 3,749E-03 GO:0031572|G2/M transition DNA damage checkpoint, ! positive regulation of chemokine production GO:0032722 8 5 1,000 8,594E-05 3,683E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 8,594E-05 3,62E-03 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 8,655E-05 3,584E-03 ! response to hypoxia GO:0001666 178 81 3,000 1,004E-04 4,089E-03 ! iron ion homeostasis GO:0055072 60 31 2,000 1,06E-04 4,246E-03 ! response to oxygen levels GO:0070482 183 83 3,000 1,104E-04 4,351E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 1,167E-04 4,527E-03 ! cellular response to hormone stimulus GO:0032870 182 85 3,000 1,211E-04 4,623E-03 ! positive regulation of gene-specific transcription GO:0043193 70 33 2,000 1,281E-04 4,816E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 1,287E-04 4,762E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 1,287E-04 4,691E-03 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 1,287E-04 4,622E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 1,287E-04 4,555E-03 ! oxygen homeostasis GO:0032364 10 6 1,000 1,287E-04 4,49E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 1,287E-04 4,427E-03 ! DNA damage checkpoint GO:0000077 78 35 2,000 1,53E-04 5,193E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 1,798E-04 6,016E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,798E-04 5,935E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,798E-04 5,856E-03 ! mRNA stabilization GO:0048255 18 7 1,000 1,798E-04 5,779E-03 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 1,798E-04 5,704E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 1,798E-04 5,631E-03 ! male sex determination GO:0030238 15 7 1,000 1,798E-04 5,559E-03 ! monocyte differentiation GO:0030224 16 7 1,000 1,798E-04 5,49E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 1,798E-04 5,422E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 1,798E-04 5,356E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 1,798E-04 5,291E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 1,798E-04 5,228E-03 ! tissue remodeling GO:0048771 78 37 2,000 1,809E-04 5,2E-03 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 1,96E-04 5,568E-03 ! DNA integrity checkpoint GO:0031570 82 38 2,000 1,96E-04 5,504E-03 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 1,96E-04 5,441E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 2,098E-04 5,759E-03 ! mitotic cell cycle checkpoint GO:0007093 76 39 2,000 2,119E-04 5,751E-03 ! carbohydrate homeostasis GO:0033500 59 39 2,000 2,119E-04 5,688E-03 GO:0042593|glucose homeostasis, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 2,392E-04 6,353E-03 ! succinate metabolic process GO:0006105 17 8 1,000 2,392E-04 6,284E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 2,392E-04 6,218E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 2,392E-04 6,152E-03 ! hemoglobin metabolic process GO:0020027 14 8 1,000 2,392E-04 6,088E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 2,392E-04 6,025E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 2,392E-04 5,964E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,392E-04 5,904E-03 ! gas homeostasis GO:0033483 14 8 1,000 2,392E-04 5,845E-03 ! response to tumor cell GO:0002347 16 8 1,000 2,392E-04 5,787E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 2,392E-04 5,73E-03 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 2,392E-04 5,674E-03 ! multicellular organismal metabolic process GO:0044236 64 41 2,000 2,461E-04 5,78E-03 ! induction of positive chemotaxis GO:0050930 17 9 1,000 3,07E-04 7,143E-03 ! microtubule bundle formation GO:0001578 22 9 1,000 3,07E-04 7,075E-03 ! middle ear morphogenesis GO:0042474 14 9 1,000 3,07E-04 7,009E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 3,07E-04 6,944E-03 ! regulation of telomere maintenance GO:0032204 17 9 1,000 3,07E-04 6,881E-03 ! keratinocyte differentiation GO:0030216 81 45 2,000 3,248E-04 7,213E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 3,467E-04 7,63E-03 ! pigmentation GO:0043473 103 46 2,000 3,467E-04 7,562E-03 ! response to insulin stimulus GO:0032868 98 47 2,000 3,695E-04 7,989E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 3,83E-04 8,208E-03 ! lung alveolus development GO:0048286 26 10 1,000 3,83E-04 8,136E-03 ! phosphagen metabolic process GO:0006599 17 10 1,000 3,83E-04 8,066E-03 GO:0006600|creatine metabolic process, ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 3,83E-04 7,997E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 3,83E-04 7,929E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 3,83E-04 7,863E-03 ! mitochondrial transport GO:0006839 94 48 2,000 3,933E-04 8,007E-03 ! activation of caspase activity GO:0006919 95 50 2,000 4,438E-04 8,961E-03 ! epidermal cell differentiation GO:0009913 87 50 2,000 4,438E-04 8,887E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 4,672E-04 9,28E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 4,672E-04 9,205E-03 ! detection of mechanical stimulus GO:0050982 22 11 1,000 4,672E-04 9,131E-03 ! blood vessel remodeling GO:0001974 30 11 1,000 4,672E-04 9,059E-03 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 4,672E-04 8,987E-03 ! regulation of intracellular pH GO:0051453 21 11 1,000 4,672E-04 8,917E-03 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 4,672E-04 8,848E-03 ! DNA methylation GO:0006306 19 11 1,000 4,672E-04 8,78E-03 GO:0006305|DNA alkylation, ! apical protein localization GO:0045176 18 11 1,000 4,672E-04 8,713E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 4,672E-04 8,647E-03 ! regulation of embryonic development GO:0045995 35 11 1,000 4,672E-04 8,582E-03 ! positive regulation of growth GO:0045927 96 53 2,000 5,27E-04 9,609E-03 ! membrane fusion GO:0006944 122 54 2,000 5,569E-04 0,01007696 ! regulation of cell shape GO:0008360 142 54 2,000 5,569E-04 0,01000287 ! virus-host interaction GO:0019048 30 12 1,000 5,596E-04 9,978E-03 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 5,596E-04 9,906E-03 GO:0050927|positive regulation of positive chemotaxis, ! histone acetylation GO:0016573 27 12 1,000 5,596E-04 9,835E-03 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 5,596E-04 9,765E-03 ! peptidyl-lysine modification GO:0018205 21 12 1,000 5,596E-04 9,695E-03 ! regulation of leukocyte migration GO:0002685 29 12 1,000 5,596E-04 9,627E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 5,596E-04 9,56E-03 ! embryonic placenta development GO:0001892 21 12 1,000 5,596E-04 9,493E-03 ! response to UV GO:0009411 120 55 2,000 5,877E-04 9,902E-03 ! positive regulation of caspase activity GO:0043280 108 57 2,000 6,527E-04 0,01092129 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 105 57 2,000 6,527E-04 0,01084699 ! regulation of chemokine production GO:0032642 18 13 1,000 6,6E-04 0,01089508 ! Golgi organization GO:0007030 25 13 1,000 6,6E-04 0,01082196 ! response to X-ray GO:0010165 28 13 1,000 6,6E-04 0,01074981 ! asymmetric protein localization GO:0008105 24 13 1,000 6,6E-04 0,01067862 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 6,6E-04 0,01060837 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 6,6E-04 0,01053903 ! regulation of mRNA stability GO:0043488 32 13 1,000 6,6E-04 0,01047059 ! regulation of cellular pH GO:0030641 27 14 1,000 7,686E-04 0,01211349 ! response to gamma radiation GO:0010332 30 14 1,000 7,686E-04 0,01203584 ! male genitalia development GO:0030539 26 14 1,000 7,686E-04 0,01195918 ! regulation of RNA stability GO:0043487 33 14 1,000 7,686E-04 0,01188349 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 8,851E-04 0,01359923 ! ER-associated protein catabolic process GO:0030433 24 15 1,000 8,851E-04 0,01351423 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! negative regulation of bone remodeling GO:0046851 34 15 1,000 8,851E-04 0,01343029 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 8,851E-04 0,01334739 ! G1/S transition checkpoint GO:0031575 37 15 1,000 8,851E-04 0,0132655 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 8,851E-04 0,01318462 ! muscle maintenance GO:0046716 26 15 1,000 8,851E-04 0,01310471 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 8,851E-04 0,01302576 ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 9,156E-04 0,01339345 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 9,156E-04 0,01331373 ! regulation of cytokine biosynthetic process GO:0042035 108 66 2,000 1,001E-03 0,01447405 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 1,01E-03 0,01450831 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 1,01E-03 0,01442347 ! activation of MAPK activity GO:0000187 124 67 2,000 1,046E-03 0,01485643 ! regulation of survival gene product expression GO:0045884 38 17 1,000 1,142E-03 0,0161265 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 1,142E-03 0,01603382 GO:0031114|regulation of microtubule depolymerization, ! genitalia development GO:0048806 32 17 1,000 1,142E-03 0,0159422 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 1,142E-03 0,01585162 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 1,142E-03 0,01576206 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 1,142E-03 0,01567351 ! cell cycle checkpoint GO:0000075 145 71 2,000 1,237E-03 0,01688693 ! heart looping GO:0001947 34 18 1,000 1,282E-03 0,0174032 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 1,282E-03 0,01730705 ! neural crest cell migration GO:0001755 41 18 1,000 1,282E-03 0,01721196 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 1,282E-03 0,0171179 ! regulation of caspase activity GO:0043281 136 74 2,000 1,394E-03 0,01851331 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 1,394E-03 0,01841324 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 1,43E-03 0,01878696 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 1,43E-03 0,0186865 ! cellular pigmentation GO:0033059 37 19 1,000 1,43E-03 0,0185871 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 1,563E-03 0,02020861 ! regulation of catabolic process GO:0009894 173 77 2,000 1,563E-03 0,02010224 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 1,586E-03 0,02028883 ! protein amino acid acetylation GO:0006473 41 20 1,000 1,586E-03 0,02018316 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 1,586E-03 0,02007858 ! response to alkaloid GO:0043279 38 20 1,000 1,586E-03 0,01997508 ! cellular response to unfolded protein GO:0034620 35 20 1,000 1,586E-03 0,01987265 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 1,586E-03 0,01977125 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 1,586E-03 0,01967089 ! protein oligomerization GO:0051259 149 79 2,000 1,683E-03 0,0207647 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 1,75E-03 0,02148159 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 1,75E-03 0,02137418 ! plasma membrane fusion GO:0045026 33 21 1,000 1,75E-03 0,02126784 ! negative regulation of angiogenesis GO:0016525 49 21 1,000 1,75E-03 0,02116256 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 1,75E-03 0,02105831 ! positive regulation of phosphorylation GO:0042327 149 81 2,000 1,808E-03 0,02165192 ! regulation of peptidase activity GO:0052547 150 82 2,000 1,873E-03 0,02231685 ! protein import into nucleus GO:0006606 174 82 2,000 1,873E-03 0,02220851 ! cellular response to starvation GO:0009267 37 22 1,000 1,921E-03 0,02267282 ! apoptotic nuclear changes GO:0030262 34 22 1,000 1,921E-03 0,02256381 ! cell aging GO:0007569 48 22 1,000 1,921E-03 0,02245585 ! positive regulation of locomotion GO:0040017 44 22 1,000 1,921E-03 0,02234892 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 1,000 1,921E-03 0,022243 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 1,921E-03 0,02213808 ! peptidyl-serine modification GO:0018209 50 22 1,000 1,921E-03 0,02203415 ! response to drug GO:0042493 149 83 2,000 1,939E-03 0,0221327 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 2,000 1,939E-03 0,02202976 GO:0045937|positive regulation of phosphate metabolic process, ! nuclear import GO:0051170 177 83 2,000 1,939E-03 0,02192777 ! response to nutrient GO:0007584 135 84 2,000 2,006E-03 0,02258688 ! negative regulation of growth GO:0045926 168 85 2,000 2,075E-03 0,02325618 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 2,1E-03 0,02342632 ! regulation of chemotaxis GO:0050920 45 23 1,000 2,1E-03 0,02331984 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 2,1E-03 0,02321432 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 2,1E-03 0,02310975 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 2,1E-03 0,02300612 ! DNA modification GO:0006304 36 23 1,000 2,1E-03 0,02290341 ! mitochondrion organization GO:0007005 159 87 2,000 2,218E-03 0,02407799 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 2,287E-03 0,02471681 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 2,287E-03 0,02460793 ! sex determination GO:0007530 48 24 1,000 2,287E-03 0,0245 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 2,287E-03 0,02439301 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 2,287E-03 0,02428695 ! protein localization in nucleus GO:0034504 192 89 2,000 2,366E-03 0,0250204 ! positive regulation of protein modification process GO:0031401 156 90 2,000 2,442E-03 0,02571673 ! response to unfolded protein GO:0006986 139 90 2,000 2,442E-03 0,02560636 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 2,481E-03 0,02589771 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 2,481E-03 0,02578751 ! myeloid leukocyte differentiation GO:0002573 46 25 1,000 2,481E-03 0,02567824 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 2,481E-03 0,02556989 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 2,481E-03 0,02546246 ! vasculogenesis GO:0001570 49 25 1,000 2,481E-03 0,02535592 ! negative regulation of DNA replication GO:0008156 45 25 1,000 2,481E-03 0,02525027 ! regulation of behavior GO:0050795 48 25 1,000 2,481E-03 0,0251455 ! interaction with host GO:0051701 66 25 1,000 2,481E-03 0,02504159 ! regulation of cell morphogenesis GO:0022604 243 93 2,000 2,68E-03 0,02694747 ! positive regulation of MAP kinase activity GO:0043406 174 93 2,000 2,68E-03 0,02683703 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 2,682E-03 0,0267447 ! neural crest cell development GO:0014032 59 26 1,000 2,682E-03 0,02663598 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 83 26 1,000 2,682E-03 0,02652814 GO:0050768|negative regulation of neurogenesis, ! odontogenesis of dentine-containing tooth GO:0042475 54 27 1,000 2,891E-03 0,02848004 ! mitochondrial membrane organization GO:0007006 60 27 1,000 2,891E-03 0,02836566 ! response to starvation GO:0042594 47 27 1,000 2,891E-03 0,0282522 ! regulation of chromosome organization GO:0033044 49 27 1,000 2,891E-03 0,02813964 ! cellular response to nutrient levels GO:0031669 45 27 1,000 2,891E-03 0,02802797 ! response to protein stimulus GO:0051789 158 96 2,000 2,932E-03 0,02831645 ! protein amino acid acylation GO:0043543 59 28 1,000 3,108E-03 0,02988877 ! dendrite development GO:0016358 67 28 1,000 3,108E-03 0,02977155 ! fat cell differentiation GO:0045444 57 28 1,000 3,108E-03 0,02965526 ! base-excision repair GO:0006284 41 28 1,000 3,108E-03 0,02953987 ! leukocyte differentiation GO:0002521 232 98 2,000 3,108E-03 0,02943312 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 3,331E-03 0,03142253 ! somitogenesis GO:0001756 52 29 1,000 3,331E-03 0,03130168 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 3,562E-03 0,03334485 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 3,801E-03 0,03544028 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 3,801E-03 0,03530552 ! response to heat GO:0009408 54 31 1,000 3,801E-03 0,03517179 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 4,046E-03 0,03730326 ! collagen metabolic process GO:0032963 49 32 1,000 4,046E-03 0,03716302 ! response to mechanical stimulus GO:0009612 60 32 1,000 4,046E-03 0,03702384 ! regulation of pH GO:0006885 56 33 1,000 4,299E-03 0,03919006 ! response to ionizing radiation GO:0010212 74 33 1,000 4,299E-03 0,03904437 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 4,559E-03 0,0412517 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 4,826E-03 0,04350674 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 1,000 4,826E-03 0,04334679 ! placenta development GO:0001890 53 35 1,000 4,826E-03 0,04318801 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 5,1E-03 0,04547421 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 5,1E-03 0,04530885 ! embryonic organ development GO:0048568 67 36 1,000 5,1E-03 0,04514468 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 5,381E-03 0,04746092 ! odontogenesis GO:0042476 74 37 1,000 5,381E-03 0,04729019 ! regulation of microtubule-based process GO:0032886 86 37 1,000 5,381E-03 0,04712069 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 5,669E-03 0,04946587 ! glycogen metabolic process GO:0005977 63 38 1,000 5,669E-03 0,04928983 ! glucan metabolic process GO:0044042 64 39 1,000 5,964E-03 0,0516707 GO:0006073|cellular glucan metabolic process, ! nucleus organization GO:0006997 73 40 1,000 6,266E-03 0,05409417 ! cellular amide metabolic process GO:0043603 73 41 1,000 6,575E-03 0,05655944 ! mesenchymal cell development GO:0014031 94 41 1,000 6,575E-03 0,05636098 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 6,575E-03 0,05616392 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 6,891E-03 0,05865409 ! ear morphogenesis GO:0042471 64 42 1,000 6,891E-03 0,05845043 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 6,891E-03 0,05824818 ! T cell differentiation GO:0030217 93 42 1,000 6,891E-03 0,05804732 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 7,213E-03 0,06055352 GO:0090047|positive regulation of transcription regulator activity, ! development of primary male sexual characteristics GO:0046546 80 43 1,000 7,213E-03 0,06034615 ! segmentation GO:0035282 78 43 1,000 7,213E-03 0,06014019 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 7,213E-03 0,05993563 ! response to reactive oxygen species GO:0000302 75 44 1,000 7,542E-03 0,06245707 ! energy reserve metabolic process GO:0006112 76 44 1,000 7,542E-03 0,06224607 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 7,542E-03 0,06203648 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 7,542E-03 0,06182831 ! double-strand break repair GO:0006302 85 44 1,000 7,542E-03 0,06162153 ! biopolymer methylation GO:0043414 91 45 1,000 7,878E-03 0,06414967 ! B cell differentiation GO:0030183 124 45 1,000 7,878E-03 0,06393655 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 8,22E-03 0,06649395 ! negative regulation of cell migration GO:0030336 122 46 1,000 8,22E-03 0,0662745 ! positive regulation of protein transport GO:0051222 80 46 1,000 8,22E-03 0,06605649 ! positive regulation of cell cycle GO:0045787 96 48 1,000 8,924E-03 0,07148172 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 8,924E-03 0,07124812 ! cellular component disassembly GO:0022411 89 48 1,000 8,924E-03 0,07101604 ! positive regulation of DNA binding GO:0043388 83 48 1,000 8,924E-03 0,07078547 ! vascular process in circulatory system GO:0003018 85 48 1,000 8,924E-03 0,07055639 ! male sex differentiation GO:0046661 93 48 1,000 8,924E-03 0,07032879 ! JAK-STAT cascade GO:0007259 82 48 1,000 8,924E-03 0,07010265 ! methylation GO:0032259 97 48 1,000 8,924E-03 0,06987796 ! response to calcium ion GO:0051592 94 49 1,000 9,286E-03 0,07247988 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 9,286E-03 0,07224905 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 9,655E-03 0,0748771 ! positive regulation of cytokine production GO:0001819 94 50 1,000 9,655E-03 0,07464014 ! response to temperature stimulus GO:0009266 84 51 1,000 0,0100295 0,0772936 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,0100295 0,07705054 ! positive regulation of binding GO:0051099 88 52 1,000 0,01041075 0,07972873 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,01041075 0,07947957 ! histone modification GO:0016570 104 52 1,000 0,01041075 0,07923197 ! amino acid activation GO:0043038 98 52 1,000 0,01041075 0,07898591 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! chromatin remodeling GO:0006338 122 53 1,000 0,01079835 0,08167294 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,01079835 0,08142087 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,01079835 0,08117034 ! cartilage development GO:0051216 99 53 1,000 0,01079835 0,08092135 ! regulation of translational initiation GO:0006446 87 54 1,000 0,01119225 0,08361672 ! covalent chromatin modification GO:0016569 115 54 1,000 0,01119225 0,08336179 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,01159242 0,0860799 ! negative regulation of cell motion GO:0051271 142 55 1,000 0,01159242 0,08581905 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,01199882 0,08855927 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 1,000 0,01241141 0,09132851 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,01241141 0,09105425 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,01241141 0,09078164 ! regulation of intracellular transport GO:0032386 108 57 1,000 0,01241141 0,09051065 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,01283014 0,09328583 ! aging GO:0007568 112 58 1,000 0,01283014 0,09300901 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,01283014 0,09273384 ! DNA catabolic process GO:0006308 94 60 1,000 0,0136859 0,09862732 ! viral reproductive process GO:0022415 132 62 1,000 0,01456579 0,10465948 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01468424 0,10520115 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01468424 0,10489355 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01468424 0,10458774 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01468424 0,1042837 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01468424 0,10398143 ! neuron fate determination GO:0048664 7 5 0,000 0,01468424 0,10368091 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01468424 0,10338211 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01468424 0,10308504 ! polyol transport GO:0015791 12 5 0,000 0,01468424 0,10278967 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01468424 0,10249598 ! response to superoxide GO:0000303 10 5 0,000 0,01468424 0,10220397 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01468424 0,10191362 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01468424 0,10162491 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01468424 0,10133783 ! female meiosis GO:0007143 10 5 0,000 0,01468424 0,10105238 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01468424 0,10076852 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01468424 0,10048626 ! hypothalamus development GO:0021854 9 5 0,000 0,01468424 0,10020557 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01468424 0,09992644 ! cobalt ion transport GO:0006824 11 5 0,000 0,01468424 0,09964887 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01468424 0,09937284 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01468424 0,09909832 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01468424 0,09882533 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01468424 0,09855383 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01468424 0,09828382 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01468424 0,09801528 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01468424 0,09774821 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01468424 0,09748259 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01468424 0,09721841 ! transposition GO:0032196 9 5 0,000 0,01468424 0,09695566 ! negative chemotaxis GO:0050919 16 5 0,000 0,01468424 0,09669432 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01468424 0,09643439 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01468424 0,09617585 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01468424 0,0959187 ! behavioral response to pain GO:0048266 10 5 0,000 0,01468424 0,09566292 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01468424 0,09540849 ! Notch receptor processing GO:0007220 11 5 0,000 0,01468424 0,09515542 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01468424 0,09490369 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01468424 0,09465328 ! micturition GO:0060073 9 5 0,000 0,01468424 0,09440419 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01468424 0,09415641 ! copulation GO:0007620 9 5 0,000 0,01468424 0,09390993 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01468424 0,09366473 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01468424 0,09342082 ! bioluminescence GO:0008218 9 5 0,000 0,01468424 0,09317816 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01468424 0,09293677 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01468424 0,09269662 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01468424 0,09245772 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01468424 0,09222003 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01468424 0,09198357 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01468424 0,09174832 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01468424 0,09151427 ! grooming behavior GO:0007625 6 5 0,000 0,01468424 0,09128141 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01468424 0,09104973 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01468424 0,09081922 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01468424 0,09058988 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01468424 0,0903617 ! response to protozoan GO:0001562 13 5 0,000 0,01468424 0,09013466 ! lymph vessel development GO:0001945 10 5 0,000 0,01468424 0,08990876 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01468424 0,08968398 ! endochondral ossification GO:0001958 17 5 0,000 0,01468424 0,08946033 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01468424 0,08923779 ! single strand break repair GO:0000012 8 5 0,000 0,01468424 0,08901636 ! parathyroid gland development GO:0060017 14 5 0,000 0,01468424 0,08879602 ! anagen GO:0042640 7 5 0,000 0,01468424 0,08857677 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01468424 0,0883586 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01468424 0,08814151 ! cytokine secretion GO:0050663 15 5 0,000 0,01468424 0,08792547 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01468424 0,0877105 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01468424 0,08749657 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01468424 0,08728368 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01468424 0,08707183 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01468424 0,086861 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01468424 0,08665119 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01468424 0,08644239 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01468424 0,0862346 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01468424 0,0860278 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01468424 0,08582199 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01468424 0,08561717 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01468424 0,08541332 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01468424 0,08521044 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01468424 0,08500852 ! microvillus organization GO:0032528 8 5 0,000 0,01468424 0,08480755 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01468424 0,08460753 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01468424 0,08440846 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01468424 0,08421031 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01468424 0,0840131 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01468424 0,08381681 ! polyol catabolic process GO:0046174 9 5 0,000 0,01468424 0,08362143 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01468424 0,08342696 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01468424 0,0832334 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01468424 0,08304073 ! muscle cell migration GO:0014812 8 5 0,000 0,01468424 0,08284895 ! mitochondrial fission GO:0000266 8 5 0,000 0,01468424 0,08265805 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01468424 0,08246803 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01468424 0,08227888 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01468424 0,0820906 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01468424 0,08190318 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01468424 0,08171661 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01468424 0,08153089 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01468424 0,08134602 ! monocyte activation GO:0042117 10 5 0,000 0,01468424 0,08116198 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01468424 0,08097877 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01468424 0,08079638 ! response to food GO:0032094 6 5 0,000 0,01468424 0,08061482 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01468424 0,08043407 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01468424 0,08025412 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01468424 0,08007499 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01468424 0,07989664 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,01468424 0,0797191 ! forebrain neuron development GO:0021884 13 5 0,000 0,01468424 0,07954234 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01468424 0,07936636 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01468424 0,07919116 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01468424 0,07901673 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01468424 0,07884306 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01468424 0,07867016 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01468424 0,07849802 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01468424 0,07832662 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01468424 0,07815598 ! lipid glycosylation GO:0030259 7 5 0,000 0,01468424 0,07798607 ! nucleobase transport GO:0015851 6 5 0,000 0,01468424 0,07781691 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01468424 0,07764847 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01468424 0,07748076 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01468424 0,07731378 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01468424 0,07714751 ! basic amino acid transport GO:0015802 12 5 0,000 0,01468424 0,07698196 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01468424 0,07681712 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01468424 0,07665298 ! actin nucleation GO:0045010 11 5 0,000 0,01468424 0,07648954 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01468424 0,07632679 ! depurination GO:0045007 5 5 0,000 0,01468424 0,07616474 ! depyrimidination GO:0045008 10 5 0,000 0,01468424 0,07600338 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01468424 0,07584269 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01468424 0,07568269 ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01468424 0,07552335 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01468424 0,07536469 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01468424 0,07520669 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01468424 0,07504936 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01468424 0,07489268 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01468424 0,07473665 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01468424 0,07458128 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01468424 0,07442654 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01468424 0,07427245 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01468424 0,07411899 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01468424 0,07396617 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01468424 0,07381398 ! response to arsenic GO:0046685 11 5 0,000 0,01468424 0,07366241 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01468424 0,07351146 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01468424 0,07336113 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01468424 0,07321142 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01468424 0,07306231 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01468424 0,07291381 ! response to mercury ion GO:0046689 8 5 0,000 0,01468424 0,07276591 ! response to cadmium ion GO:0046686 7 5 0,000 0,01468424 0,07261861 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01468424 0,07247191 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01468424 0,07232579 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01468424 0,07218027 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01468424 0,07203533 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01468424 0,07189097 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01468424 0,07174719 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01468424 0,07160398 ! decidualization GO:0046697 11 5 0,000 0,01468424 0,07146134 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01468424 0,07131927 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01468424 0,07117776 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01468424 0,07103682 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01468424 0,07089643 ! embryonic cleavage GO:0040016 6 5 0,000 0,01468424 0,07075659 ! peroxisome fission GO:0016559 5 5 0,000 0,01468424 0,07061731 ! histone demethylation GO:0016577 13 5 0,000 0,01468424 0,07047857 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01468424 0,07034038 ! mitotic recombination GO:0006312 9 5 0,000 0,01468424 0,07020273 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01468424 0,07006561 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01468424 0,06992903 ! metaphase plate congression GO:0051310 7 5 0,000 0,01468424 0,06979298 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01468424 0,06965746 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,01468424 0,06952247 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01468424 0,069388 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01468424 0,06925404 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01468424 0,0691206 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01468424 0,06898768 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01468424 0,06885527 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01468424 0,06872336 ! B cell homeostasis GO:0001782 13 5 0,000 0,01468424 0,06859196 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01468424 0,06846106 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01468424 0,06833065 ! metaphase GO:0051323 11 5 0,000 0,01468424 0,06820075 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01468424 0,06807133 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01468424 0,06794241 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01468424 0,06781398 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01468424 0,06768603 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01468424 0,06755856 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01468424 0,06743157 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01468424 0,06730505 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01468424 0,06717901 ! response to redox state GO:0051775 6 5 0,000 0,01468424 0,06705345 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01468424 0,06692835 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01468424 0,06680371 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01468424 0,06667954 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01468424 0,06655583 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01468424 0,06643258 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01468424 0,06630978 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01468424 0,06618744 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01468424 0,06606555 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01468424 0,06594411 ! striatum development GO:0021756 14 5 0,000 0,01468424 0,06582311 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01468424 0,06570255 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01468424 0,06558244 ! glial cell migration GO:0008347 10 5 0,000 0,01468424 0,06546276 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01468424 0,06534352 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01468424 0,06522472 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01468424 0,06510634 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01468424 0,06498839 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01468424 0,06487087 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01468424 0,06475378 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01468424 0,06463711 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01468424 0,06452085 ! neuroprotection GO:0043526 8 5 0,000 0,01468424 0,06440502 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01468424 0,06428959 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01468424 0,06417459 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01468424 0,06405999 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01468424 0,0639458 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01468424 0,06383202 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01468424 0,06371864 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01468424 0,06360566 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01468424 0,06349309 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01468424 0,06338091 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,01468424 0,06326912 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01468424 0,06315773 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01468424 0,06304674 ! spindle assembly GO:0051225 6 5 0,000 0,01468424 0,06293613 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01468424 0,06282591 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01468424 0,06271607 ! protein palmitoylation GO:0018345 12 5 0,000 0,01468424 0,06260662 ! drug metabolic process GO:0017144 7 5 0,000 0,01468424 0,06249755 ! stem cell division GO:0017145 11 5 0,000 0,01468424 0,06238886 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01468424 0,06228054 ! organ regeneration GO:0031100 7 5 0,000 0,01468424 0,06217261 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01468424 0,06206504 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01468424 0,06195785 ! mesoderm development GO:0007498 128 63 1,000 0,01501468 0,06324289 ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,01501468 0,06313403 ! ear development GO:0043583 114 66 1,000 0,01639671 0,06882675 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,01686904 0,07068794 ! myeloid cell differentiation GO:0030099 126 67 1,000 0,01686904 0,0705669 ! extracellular matrix organization GO:0030198 146 68 1,000 0,01734714 0,07244283 ! detection of external stimulus GO:0009581 102 68 1,000 0,01734714 0,07231921 ! viral reproduction GO:0016032 142 68 1,000 0,01734714 0,07219601 ! adaptive immune response GO:0002250 126 68 1,000 0,01734714 0,07207322 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01759535 0,07298039 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01759535 0,0728567 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01759535 0,07273342 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01759535 0,07261056 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01759535 0,07248811 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01759535 0,07236608 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01759535 0,07224445 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01759535 0,07212324 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01759535 0,07200243 ! response to oxygen radical GO:0000305 11 6 0,000 0,01759535 0,07188202 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01759535 0,07176202 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01759535 0,07164242 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01759535 0,07152321 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01759535 0,0714044 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01759535 0,07128599 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01759535 0,07116796 ! forebrain regionalization GO:0021871 9 6 0,000 0,01759535 0,07105033 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01759535 0,07093309 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01759535 0,07081623 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01759535 0,07069975 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01759535 0,07058366 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01759535 0,07046795 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01759535 0,07035262 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01759535 0,07023766 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01759535 0,07012308 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01759535 0,07000888 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01759535 0,06989504 ! malate metabolic process GO:0006108 13 6 0,000 0,01759535 0,06978157 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01759535 0,06966848 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01759535 0,06955574 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01759535 0,06944338 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01759535 0,06933137 ! protein refolding GO:0042026 15 6 0,000 0,01759535 0,06921973 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01759535 0,06910844 ! opsonization GO:0008228 8 6 0,000 0,01759535 0,06899751 ! mating behavior GO:0007617 7 6 0,000 0,01759535 0,06888694 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01759535 0,06877672 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01759535 0,06866685 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01759535 0,06855734 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01759535 0,06844817 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01759535 0,06833935 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01759535 0,06823087 ! toxin metabolic process GO:0009404 11 6 0,000 0,01759535 0,06812274 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01759535 0,06801495 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01759535 0,0679075 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01759535 0,06780039 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,01759535 0,06769362 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01759535 0,06758719 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01759535 0,06748108 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01759535 0,06737531 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01759535 0,06726987 ! thymic T cell selection GO:0045061 16 6 0,000 0,01759535 0,06716477 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01759535 0,06705998 ! protein lipoylation GO:0009249 10 6 0,000 0,01759535 0,06695553 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01759535 0,0668514 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01759535 0,06674759 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01759535 0,06664411 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01759535 0,06654094 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01759535 0,0664381 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01759535 0,06633557 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01759535 0,06623336 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01759535 0,06613146 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01759535 0,06602988 ! hyperosmotic response GO:0006972 10 6 0,000 0,01759535 0,0659286 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01759535 0,06582764 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01759535 0,06572699 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01759535 0,06562664 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01759535 0,0655266 ! urea metabolic process GO:0019627 7 6 0,000 0,01759535 0,06542686 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01759535 0,06532743 ! neutrophil activation GO:0042119 7 6 0,000 0,01759535 0,0652283 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01759535 0,06512947 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01759535 0,06503094 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01759535 0,0649327 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01759535 0,06483477 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01759535 0,06473712 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01759535 0,06463977 ! neuron apoptosis GO:0051402 15 6 0,000 0,01759535 0,06454272 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01759535 0,06444595 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01759535 0,06434948 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01759535 0,06425329 ! carnitine transport GO:0015879 10 6 0,000 0,01759535 0,06415739 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01759535 0,06406177 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01759535 0,06396644 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01759535 0,0638714 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01759535 0,06377663 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01759535 0,06368215 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01759535 0,06358794 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01759535 0,06349402 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01759535 0,06340037 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01759535 0,063307 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01759535 0,0632139 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01759535 0,06312107 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01759535 0,06302852 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01759535 0,06293624 ! response to UV-C GO:0010225 14 6 0,000 0,01759535 0,06284423 ! astrocyte development GO:0014002 16 6 0,000 0,01759535 0,06275248 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01759535 0,06266101 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01759535 0,0625698 ! interaction with symbiont GO:0051702 14 6 0,000 0,01759535 0,06247885 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01759535 0,06238817 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01759535 0,06229775 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01759535 0,0622076 ! response to copper ion GO:0046688 10 6 0,000 0,01759535 0,0621177 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01759535 0,06202807 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01759535 0,06193869 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01759535 0,06184957 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01759535 0,0617607 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01759535 0,06167209 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01759535 0,06158374 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01759535 0,06149564 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01759535 0,06140779 ! hair follicle maturation GO:0048820 8 6 0,000 0,01759535 0,06132019 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01759535 0,06123283 ! Schwann cell development GO:0014044 15 6 0,000 0,01759535 0,06114573 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01759535 0,06105888 ! response to pheromone GO:0019236 6 6 0,000 0,01759535 0,06097227 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01759535 0,06088591 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01759535 0,06079979 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01759535 0,06071391 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01759535 0,06062828 ! subpallium development GO:0021544 15 6 0,000 0,01759535 0,06054289 ! neural tube patterning GO:0021532 8 6 0,000 0,01759535 0,06045774 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01759535 0,06037282 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01759535 0,06028815 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01759535 0,06020371 ! G2 phase GO:0051319 16 6 0,000 0,01759535 0,06011951 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01759535 0,06003554 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01759535 0,05995181 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01759535 0,05986831 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01759535 0,05978505 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01759535 0,05970201 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01759535 0,05961921 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01759535 0,05953663 ! receptor internalization GO:0031623 11 6 0,000 0,01759535 0,05945429 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,01759535 0,05937217 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,01759535 0,05929028 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01759535 0,05920861 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01759535 0,05912717 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01759535 0,05904595 ! protein deubiquitination GO:0016579 16 6 0,000 0,01759535 0,05896495 ! protein destabilization GO:0031648 9 6 0,000 0,01759535 0,05888418 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01759535 0,05880363 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01759535 0,05872329 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01759535 0,05864318 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01759535 0,05856328 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01759535 0,05848361 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01759535 0,05840414 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01759535 0,0583249 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01759535 0,05824587 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01759535 0,05816705 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01759535 0,05808845 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01759535 0,05801005 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01759535 0,05793187 ! neural plate development GO:0001840 9 6 0,000 0,01759535 0,0578539 ! catecholamine transport GO:0051937 9 6 0,000 0,01759535 0,05777614 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01759535 0,05769859 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01759535 0,05762125 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01759535 0,05754411 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01759535 0,05746718 ! maternal placenta development GO:0001893 12 6 0,000 0,01759535 0,05739045 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01759535 0,05731393 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01759535 0,05723762 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01759535 0,0571615 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01759535 0,05708559 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01759535 0,05700988 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01759535 0,05693437 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01759535 0,05685906 GO:0055081|anion homeostasis, ! negative regulation of cell size GO:0045792 144 69 1,000 0,01783096 0,0575443 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,01783096 0,05746838 ! B cell activation GO:0042113 179 72 1,000 0,01931641 0,06217391 ! tRNA transcription GO:0009304 17 7 0,000 0,02049795 0,06589012 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02049795 0,06580354 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02049795 0,06571718 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02049795 0,06563105 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02049795 0,06554515 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02049795 0,06545947 ! sleep GO:0030431 16 7 0,000 0,02049795 0,06537401 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02049795 0,06528878 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02049795 0,06520377 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02049795 0,06511898 ! prostate gland development GO:0030850 14 7 0,000 0,02049795 0,06503441 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02049795 0,06495006 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02049795 0,06486593 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02049795 0,06478201 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02049795 0,06469831 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02049795 0,06461483 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02049795 0,06453156 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02049795 0,06444851 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02049795 0,06436567 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02049795 0,06428305 ! glycolipid transport GO:0046836 11 7 0,000 0,02049795 0,06420063 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02049795 0,06411843 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,02049795 0,06403644 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02049795 0,06395465 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02049795 0,06387308 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02049795 0,06379171 ! pericardium development GO:0060039 16 7 0,000 0,02049795 0,06371055 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02049795 0,0636296 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02049795 0,06354885 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02049795 0,06346831 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02049795 0,06338797 ! lipoprotein transport GO:0042953 14 7 0,000 0,02049795 0,06330783 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02049795 0,0632279 ! rhythmic behavior GO:0007622 17 7 0,000 0,02049795 0,06314816 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02049795 0,06306863 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02049795 0,0629893 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02049795 0,06291017 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02049795 0,06283123 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02049795 0,0627525 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02049795 0,06267396 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02049795 0,06259562 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02049795 0,06251747 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02049795 0,06243952 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02049795 0,06236176 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02049795 0,0622842 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02049795 0,06220683 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02049795 0,06212965 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02049795 0,06205266 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02049795 0,06197586 ! spinal cord patterning GO:0021511 14 7 0,000 0,02049795 0,06189925 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02049795 0,06182283 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02049795 0,0617466 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02049795 0,06167056 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02049795 0,0615947 ! adrenal gland development GO:0030325 17 7 0,000 0,02049795 0,06151903 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02049795 0,06144355 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02049795 0,06136825 ! ovulation GO:0030728 10 7 0,000 0,02049795 0,06129314 ! adenohypophysis development GO:0021984 11 7 0,000 0,02049795 0,06121821 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02049795 0,06114346 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02049795 0,0610689 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02049795 0,06099451 ! microtubule nucleation GO:0007020 21 7 0,000 0,02049795 0,06092031 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02049795 0,06084629 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02049795 0,06077244 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02049795 0,06069878 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02049795 0,0606253 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02049795 0,06055199 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02049795 0,06047886 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02049795 0,0604059 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02049795 0,06033313 ! galactose metabolic process GO:0006012 13 7 0,000 0,02049795 0,06026052 ! vesicle fusion GO:0006906 20 7 0,000 0,02049795 0,06018809 ! response to dietary excess GO:0002021 8 7 0,000 0,02049795 0,06011584 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02049795 0,06004376 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02049795 0,05997185 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02049795 0,05990011 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02049795 0,05982855 ! organ growth GO:0035265 15 7 0,000 0,02049795 0,05975715 ! nucleoside transport GO:0015858 11 7 0,000 0,02049795 0,05968593 ! nucleoside salvage GO:0043174 11 7 0,000 0,02049795 0,05961487 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02049795 0,05954399 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02049795 0,05947327 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02049795 0,05940272 ! parturition GO:0007567 16 7 0,000 0,02049795 0,05933234 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02049795 0,05926212 ! rRNA modification GO:0000154 14 7 0,000 0,02049795 0,05919207 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02049795 0,05912219 ! spindle checkpoint GO:0031577 16 7 0,000 0,02049795 0,05905247 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02049795 0,05898291 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02049795 0,05891352 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02049795 0,05884429 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02049795 0,05877523 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02049795 0,05870632 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02049795 0,05863758 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02049795 0,058569 ! fibrinolysis GO:0042730 11 7 0,000 0,02049795 0,05850058 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02049795 0,05843232 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02049795 0,05836421 ! eating behavior GO:0042755 8 7 0,000 0,02049795 0,05829627 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02049795 0,05822848 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02049795 0,05816085 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02049795 0,05809338 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02049795 0,05802607 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,02049795 0,05795891 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02049795 0,0578919 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02049795 0,05782505 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02049795 0,05775836 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02049795 0,05769181 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02049795 0,05762542 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02049795 0,05755919 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02049795 0,0574931 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02049795 0,05742717 ! histone ubiquitination GO:0016574 9 7 0,000 0,02049795 0,05736139 ! regulation of meiosis GO:0040020 12 7 0,000 0,02049795 0,05729576 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02049795 0,05723028 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02049795 0,05716495 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02049795 0,05709977 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02049795 0,05703473 ! transcription termination GO:0006353 14 7 0,000 0,02049795 0,05696985 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02049795 0,05690511 ! anaphase GO:0051322 18 7 0,000 0,02049795 0,05684052 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02049795 0,05677607 ! axonal fasciculation GO:0007413 19 7 0,000 0,02049795 0,05671177 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02049795 0,05664762 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02049795 0,05658361 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02049795 0,05651975 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02049795 0,05645603 ! diuresis GO:0030146 12 7 0,000 0,02049795 0,05639245 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02049795 0,05632901 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02049795 0,05626572 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02049795 0,05620257 ! antibiotic transport GO:0042891 9 7 0,000 0,02049795 0,05613957 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02049795 0,0560767 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02049795 0,05601398 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02049795 0,05595139 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02049795 0,05588894 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02049795 0,05582664 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02049795 0,05576447 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02049795 0,05570244 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02049795 0,05564055 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02049795 0,05557879 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02049795 0,05551718 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02049795 0,0554557 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02049795 0,05539435 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02049795 0,05533314 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02049795 0,05527207 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02049795 0,05521113 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02049795 0,05515032 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02049795 0,05508965 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02049795 0,05502911 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02049795 0,05496871 ! muscle adaptation GO:0043500 13 7 0,000 0,02049795 0,05490844 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02049795 0,0548483 ! retina homeostasis GO:0001895 12 7 0,000 0,02049795 0,05478829 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02049795 0,05472841 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02049795 0,05466866 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02049795 0,05460904 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02049795 0,05454956 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,02085208 0,05543158 GO:0090046|regulation of transcription regulator activity, ! cell-matrix adhesion GO:0007160 181 76 1,000 0,02137495 0,05675979 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,02137495 0,05669816 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02339205 0,06198133 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02339205 0,06191418 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02339205 0,06184717 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02339205 0,06178031 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02339205 0,06171359 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02339205 0,06164702 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02339205 0,06158059 ! male meiosis GO:0007140 9 8 0,000 0,02339205 0,0615143 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02339205 0,06144816 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02339205 0,06138215 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02339205 0,06131629 ! meiotic prophase I GO:0007128 14 8 0,000 0,02339205 0,06125057 ! response to zinc ion GO:0010043 12 8 0,000 0,02339205 0,061185 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,02339205 0,06111956 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02339205 0,06105426 ! oligopeptide transport GO:0006857 16 8 0,000 0,02339205 0,0609891 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02339205 0,06092408 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02339205 0,0608592 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02339205 0,06079445 ! signal peptide processing GO:0006465 12 8 0,000 0,02339205 0,06072985 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02339205 0,06066538 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02339205 0,06060105 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02339205 0,06053685 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02339205 0,06047279 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02339205 0,06040887 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02339205 0,06034508 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02339205 0,06028142 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02339205 0,0602179 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02339205 0,06015451 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02339205 0,06009126 ! reflex GO:0060004 17 8 0,000 0,02339205 0,06002814 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02339205 0,05996515 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02339205 0,05990229 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02339205 0,05983957 ! pigment granule organization GO:0048753 17 8 0,000 0,02339205 0,05977697 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02339205 0,05971451 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02339205 0,05965218 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02339205 0,05958998 ! histidine catabolic process GO:0006548 10 8 0,000 0,02339205 0,0595279 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02339205 0,05946596 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02339205 0,05940414 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02339205 0,05934246 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02339205 0,0592809 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02339205 0,05921947 ! melanin metabolic process GO:0006582 17 8 0,000 0,02339205 0,05915816 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02339205 0,05909699 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02339205 0,05903594 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02339205 0,05897501 ! macrophage activation GO:0042116 13 8 0,000 0,02339205 0,05891421 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02339205 0,05885354 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02339205 0,05879299 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02339205 0,05873257 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02339205 0,05867227 ! purine salvage GO:0043101 12 8 0,000 0,02339205 0,05861209 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02339205 0,05855204 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02339205 0,0584921 ! osteoblast development GO:0002076 17 8 0,000 0,02339205 0,0584323 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02339205 0,05837261 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02339205 0,05831305 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02339205 0,0582536 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02339205 0,05819428 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02339205 0,05813508 ! response to UV-B GO:0010224 17 8 0,000 0,02339205 0,058076 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02339205 0,05801704 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02339205 0,0579582 ! intermediate filament organization GO:0045109 12 8 0,000 0,02339205 0,05789948 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02339205 0,05784088 ! cellular extravasation GO:0045123 13 8 0,000 0,02339205 0,05778239 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02339205 0,05772403 ! response to antibiotic GO:0046677 11 8 0,000 0,02339205 0,05766578 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02339205 0,05760765 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02339205 0,05754963 ! DNA topological change GO:0006265 12 8 0,000 0,02339205 0,05749174 ! response to tropane GO:0014073 15 8 0,000 0,02339205 0,05743396 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,02339205 0,05737629 ! melanosome transport GO:0032402 13 8 0,000 0,02339205 0,05731874 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 0,000 0,02339205 0,05726131 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02339205 0,05720399 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02339205 0,05714679 ! mast cell activation GO:0045576 14 8 0,000 0,02339205 0,0570897 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02339205 0,05703272 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,02339205 0,05697586 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02339205 0,05691911 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02339205 0,05686247 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02339205 0,05680595 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02339205 0,05674954 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02339205 0,05669324 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,02339205 0,05663705 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02339205 0,05658098 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02339205 0,05652501 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02339205 0,05646916 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02339205 0,05641341 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02339205 0,05635778 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02339205 0,05630225 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02339205 0,05624684 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02339205 0,05619153 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02339205 0,05613633 ! hormone catabolic process GO:0042447 17 8 0,000 0,02339205 0,05608124 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02339205 0,05602626 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02339205 0,05597139 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02339205 0,05591662 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02339205 0,05586196 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02339205 0,05580741 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02339205 0,05575296 ! adult feeding behavior GO:0008343 10 8 0,000 0,02339205 0,05569862 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02339205 0,05564439 ! ATP catabolic process GO:0006200 11 8 0,000 0,02339205 0,05559026 ! blastocyst growth GO:0001832 19 8 0,000 0,02339205 0,05553624 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02339205 0,05548232 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02339205 0,0554285 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02339205 0,05537479 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02339205 0,05532119 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02339205 0,05526769 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02339205 0,05521429 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02339205 0,05516099 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02339205 0,0551078 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02339205 0,05505471 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02339205 0,05500172 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02339205 0,05494883 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02339205 0,05489605 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02339205 0,05484336 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02339205 0,05479078 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02339205 0,0547383 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02339205 0,05468592 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02339205 0,05463364 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02339205 0,05458146 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02339205 0,05452938 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,02352042 0,05477635 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,02352042 0,05472418 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,02352042 0,05467211 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,02462504 0,05718533 ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,02518519 0,0584306 ! response to metal ion GO:0010038 158 84 1,000 0,02575053 0,05968553 ! T cell activation GO:0042110 189 84 1,000 0,02575053 0,05962896 ! axon extension GO:0048675 16 9 0,000 0,02627769 0,06079203 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02627769 0,06073452 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,02627769 0,06067711 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02627769 0,06061982 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,02627769 0,06056263 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,02627769 0,06050555 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02627769 0,06044857 ! reproductive behavior GO:0019098 22 9 0,000 0,02627769 0,06039171 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02627769 0,06033495 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,02627769 0,0602783 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02627769 0,06022175 ! UTP metabolic process GO:0046051 10 9 0,000 0,02627769 0,06016531 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02627769 0,06010898 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02627769 0,06005275 ! artery development GO:0060840 25 9 0,000 0,02627769 0,05999662 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02627769 0,0599406 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,02627769 0,05988469 ! equilibrioception GO:0050957 20 9 0,000 0,02627769 0,05982888 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,02627769 0,05977317 ! chemosensory behavior GO:0007635 21 9 0,000 0,02627769 0,05971757 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02627769 0,05966207 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02627769 0,05960667 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02627769 0,05955138 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02627769 0,05949619 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02627769 0,0594411 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02627769 0,05938611 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02627769 0,05933123 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02627769 0,05927644 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02627769 0,05922176 ! protein targeting to ER GO:0045047 25 9 0,000 0,02627769 0,05916718 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02627769 0,05911269 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02627769 0,05905831 ! T cell selection GO:0045058 27 9 0,000 0,02627769 0,05900403 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02627769 0,05894985 ! glycine catabolic process GO:0006546 15 9 0,000 0,02627769 0,05889577 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,02627769 0,05884178 ! endosome organization GO:0007032 20 9 0,000 0,02627769 0,0587879 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02627769 0,05873411 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,02627769 0,05868043 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02627769 0,05862684 ! mannose metabolic process GO:0006013 13 9 0,000 0,02627769 0,05857335 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02627769 0,05851995 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02627769 0,05846665 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,02627769 0,05841345 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02627769 0,05836035 ! receptor clustering GO:0043113 20 9 0,000 0,02627769 0,05830734 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02627769 0,05825443 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02627769 0,05820162 ! retinol metabolic process GO:0042572 20 9 0,000 0,02627769 0,0581489 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02627769 0,05809628 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02627769 0,05804375 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02627769 0,05799132 ! macrophage differentiation GO:0030225 15 9 0,000 0,02627769 0,05793898 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02627769 0,05788673 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,02627769 0,05783458 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02627769 0,05778253 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02627769 0,05773056 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02627769 0,05767869 ! response to amine stimulus GO:0014075 13 9 0,000 0,02627769 0,05762692 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02627769 0,05757523 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02627769 0,05752364 ! erythrocyte development GO:0048821 17 9 0,000 0,02627769 0,05747215 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02627769 0,05742074 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02627769 0,05736942 ! renal water homeostasis GO:0003091 15 9 0,000 0,02627769 0,0573182 ! postreplication repair GO:0006301 25 9 0,000 0,02627769 0,05726707 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02627769 0,05721603 ! icosanoid secretion GO:0032309 15 9 0,000 0,02627769 0,05716508 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02627769 0,05711422 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02627769 0,05706345 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02627769 0,05701278 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02627769 0,05696219 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02627769 0,05691169 ! sterol catabolic process GO:0016127 14 9 0,000 0,02627769 0,05686128 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02627769 0,05681096 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02627769 0,05676073 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,02627769 0,05671059 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02627769 0,05666054 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,02627769 0,05661057 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02627769 0,05656069 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,02627769 0,0565109 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02627769 0,0564612 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,02627769 0,05641159 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,02627769 0,05636206 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02627769 0,05631262 ! purine base metabolic process GO:0006144 25 9 0,000 0,02627769 0,05626327 ! pigment granule transport GO:0051904 17 9 0,000 0,02627769 0,056214 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02627769 0,05616482 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02627769 0,05611572 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02627769 0,05606671 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02627769 0,05601779 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02627769 0,05596895 ! mitochondrion localization GO:0051646 18 9 0,000 0,02627769 0,0559202 ! regulation of protein transport GO:0051223 165 87 1,000 0,02747731 0,05842216 GO:0070201|regulation of establishment of protein localization, ! one-carbon metabolic process GO:0006730 167 88 1,000 0,02806304 0,05961565 ! regulation of DNA binding GO:0051101 167 89 1,000 0,02865378 0,0608177 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02915487 0,06182756 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,02915487 0,06177394 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02915487 0,06172041 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02915487 0,06166697 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02915487 0,06161363 ! associative learning GO:0008306 21 10 0,000 0,02915487 0,06156038 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,02915487 0,06150721 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02915487 0,06145415 ! phosphate transport GO:0006817 24 10 0,000 0,02915487 0,06140117 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02915487 0,06134828 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02915487 0,06129549 ! CTP metabolic process GO:0046036 11 10 0,000 0,02915487 0,06124278 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02915487 0,06119017 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02915487 0,06113764 ! GTP metabolic process GO:0046039 11 10 0,000 0,02915487 0,06108521 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02915487 0,06103287 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02915487 0,06098061 ! social behavior GO:0035176 29 10 0,000 0,02915487 0,06092845 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02915487 0,06087637 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,02915487 0,06082438 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02915487 0,06077249 ! androgen metabolic process GO:0008209 17 10 0,000 0,02915487 0,06072068 ! phospholipid efflux GO:0033700 19 10 0,000 0,02915487 0,06066896 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02915487 0,06061732 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02915487 0,06056578 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02915487 0,06051432 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02915487 0,06046295 ! pathogenesis GO:0009405 17 10 0,000 0,02915487 0,06041167 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02915487 0,06036047 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02915487 0,06030936 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02915487 0,06025834 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,02915487 0,0602074 ! endoderm development GO:0007492 18 10 0,000 0,02915487 0,06015655 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02915487 0,06010578 ! arginine catabolic process GO:0006527 17 10 0,000 0,02915487 0,0600551 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02915487 0,06000451 ! proline metabolic process GO:0006560 13 10 0,000 0,02915487 0,059954 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02915487 0,05990358 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02915487 0,05985324 ! V(D)J recombination GO:0033151 34 10 0,000 0,02915487 0,05980298 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02915487 0,05975281 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,02915487 0,05970273 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02915487 0,05965273 ! B cell proliferation GO:0042100 19 10 0,000 0,02915487 0,05960281 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02915487 0,05955297 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02915487 0,05950322 ! multicellular organism growth GO:0035264 19 10 0,000 0,02915487 0,05945355 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02915487 0,05940397 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02915487 0,05935446 ! ruffle organization GO:0031529 17 10 0,000 0,02915487 0,05930504 ! epithelial cell development GO:0002064 21 10 0,000 0,02915487 0,0592557 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02915487 0,05920645 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02915487 0,05915727 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02915487 0,05910818 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02915487 0,05905917 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02915487 0,05901024 GO:0030204|chondroitin sulfate metabolic process, ! motor axon guidance GO:0008045 22 10 0,000 0,02915487 0,05896139 ! copper ion homeostasis GO:0055070 13 10 0,000 0,02915487 0,05891262 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02915487 0,05886393 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,02915487 0,05881532 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02915487 0,05876679 ! segment specification GO:0007379 15 10 0,000 0,02915487 0,05871835 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02915487 0,05866998 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02915487 0,05862169 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02915487 0,05857348 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02915487 0,05852535 ! response to dsRNA GO:0043331 23 10 0,000 0,02915487 0,0584773 ! DNA ligation GO:0006266 18 10 0,000 0,02915487 0,05842933 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02915487 0,05838144 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02915487 0,05833362 ! melanosome localization GO:0032400 16 10 0,000 0,02915487 0,05828589 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02915487 0,05823823 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02915487 0,05819065 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,02915487 0,05814315 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02915487 0,05809572 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,02915487 0,05804837 ! induction of an organ GO:0001759 17 10 0,000 0,02915487 0,0580011 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02915487 0,05795391 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02915487 0,05790679 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02915487 0,05785975 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02915487 0,05781279 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02915487 0,0577659 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02915487 0,05771909 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02915487 0,05767235 ! salivary gland development GO:0007431 28 10 0,000 0,02915487 0,05762569 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02915487 0,05757911 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02915487 0,0575326 ! midbrain development GO:0030901 14 10 0,000 0,02915487 0,05748616 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02915487 0,0574398 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02915487 0,05739352 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02915487 0,05734731 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02915487 0,05730117 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02915487 0,05725511 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02915487 0,05720912 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02915487 0,05716321 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02915487 0,05711737 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02915487 0,0570716 ! detection of calcium ion GO:0005513 24 10 0,000 0,02915487 0,0570259 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02915487 0,05698028 ! blastocyst formation GO:0001825 18 10 0,000 0,02915487 0,05693474 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02915487 0,05688926 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02915487 0,05684386 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02915487 0,05679853 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02915487 0,05675327 ! response to nicotine GO:0035094 20 10 0,000 0,02915487 0,05670808 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02915487 0,05666297 ! response to inorganic substance GO:0010035 173 90 1,000 0,02924949 0,05680168 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 0,03106617 0,0602817 GO:0010498|proteasomal protein catabolic process, ! negative regulation of muscle development GO:0048635 27 11 0,000 0,03202364 0,06209028 ! respiratory burst GO:0045730 17 11 0,000 0,03202364 0,06204104 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03202364 0,06199188 ! neuron fate specification GO:0048665 18 11 0,000 0,03202364 0,0619428 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03202364 0,06189379 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03202364 0,06184486 ! thyroid gland development GO:0030878 26 11 0,000 0,03202364 0,06179601 ! synapsis GO:0007129 14 11 0,000 0,03202364 0,06174724 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03202364 0,06169854 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03202364 0,06164992 ! response to pain GO:0048265 27 11 0,000 0,03202364 0,06160138 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03202364 0,06155291 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,03202364 0,06150452 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 16 11 0,000 0,03202364 0,06145621 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03202364 0,06140797 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03202364 0,0613598 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03202364 0,06131172 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03202364 0,0612637 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03202364 0,06121577 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03202364 0,0611679 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03202364 0,06112012 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03202364 0,0610724 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03202364 0,06102477 ! UV protection GO:0009650 20 11 0,000 0,03202364 0,0609772 ! adult heart development GO:0007512 16 11 0,000 0,03202364 0,06092971 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03202364 0,0608823 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03202364 0,06083495 ! macroautophagy GO:0016236 19 11 0,000 0,03202364 0,06078768 ! temperature homeostasis GO:0001659 18 11 0,000 0,03202364 0,06074049 ! behavioral fear response GO:0001662 27 11 0,000 0,03202364 0,06069337 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03202364 0,06064632 ! negative regulation of ossification GO:0030279 27 11 0,000 0,03202364 0,06059934 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03202364 0,06055244 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,03202364 0,06050561 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,03202364 0,06045885 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03202364 0,06041216 ! regulation of organ growth GO:0046620 14 11 0,000 0,03202364 0,06036555 ! pigment granule localization GO:0051875 20 11 0,000 0,03202364 0,06031901 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03202364 0,06027253 ! vasoconstriction GO:0042310 20 11 0,000 0,03202364 0,06022614 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03202364 0,06017981 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03202364 0,06013355 ! embryonic axis specification GO:0000578 19 11 0,000 0,03202364 0,06008737 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03202364 0,06004125 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03202364 0,05999521 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03202364 0,05994923 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03202364 0,05990333 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03202364 0,0598575 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03202364 0,05981174 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03202364 0,05976604 ! prophase GO:0051324 17 11 0,000 0,03202364 0,05972042 ! neuroblast proliferation GO:0007405 25 11 0,000 0,03202364 0,05967487 ! nucleosome positioning GO:0016584 15 11 0,000 0,03202364 0,05962938 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03202364 0,05958397 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03202364 0,05953862 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03202364 0,05949335 ! acid secretion GO:0046717 20 11 0,000 0,03202364 0,05944814 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03202364 0,059403 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03202364 0,05935793 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03202364 0,05931293 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03202364 0,05926799 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03202364 0,05922313 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03202364 0,05917833 ! cholesterol efflux GO:0033344 21 11 0,000 0,03202364 0,0591336 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03202364 0,05908894 ! oocyte development GO:0048599 20 11 0,000 0,03202364 0,05904434 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03202364 0,05899981 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03202364 0,05895535 ! embryonic gut development GO:0048566 19 11 0,000 0,03202364 0,05891096 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03202364 0,05886663 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03202364 0,05882237 ! activation of innate immune response GO:0002218 16 11 0,000 0,03202364 0,05877817 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03202364 0,05873405 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03202364 0,05868999 ! lysogeny GO:0030069 22 11 0,000 0,03202364 0,05864599 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03202364 0,05860206 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03202364 0,0585582 ! sequestering of metal ion GO:0051238 15 11 0,000 0,03202364 0,0585144 ! nucleus localization GO:0051647 22 11 0,000 0,03202364 0,05847067 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,03230156 0,05893406 ! sex differentiation GO:0007548 171 96 1,000 0,03292643 0,06002931 ! transcription initiation GO:0006352 171 97 1,000 0,03355605 0,06113157 ! regulation of protein localization GO:0032880 188 97 1,000 0,03355605 0,06108601 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,03488401 0,06345617 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,03488401 0,06340895 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,03488401 0,06336181 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,03488401 0,06331474 ! mating GO:0007618 17 12 0,000 0,03488401 0,06326773 ! protein complex disassembly GO:0043241 28 12 0,000 0,03488401 0,0632208 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,03488401 0,06317393 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,03488401 0,06312714 ! hippocampus development GO:0021766 29 12 0,000 0,03488401 0,06308041 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,03488401 0,06303375 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,03488401 0,06298716 ! T cell proliferation GO:0042098 32 12 0,000 0,03488401 0,06294065 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,03488401 0,06289419 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,03488401 0,06284781 ! ventral spinal cord development GO:0021517 25 12 0,000 0,03488401 0,0628015 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,03488401 0,06275525 ! drug transport GO:0015893 16 12 0,000 0,03488401 0,06270908 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,03488401 0,06266297 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,03488401 0,06261692 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,03488401 0,06257095 ! polyamine metabolic process GO:0006595 18 12 0,000 0,03488401 0,06252504 ! focal adhesion formation GO:0048041 37 12 0,000 0,03488401 0,0624792 ! mitotic spindle organization GO:0007052 23 12 0,000 0,03488401 0,06243343 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,03488401 0,06238773 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,03488401 0,06234209 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,03488401 0,06229652 ! lipid digestion GO:0044241 21 12 0,000 0,03488401 0,06225101 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,03488401 0,06220557 ! entry into host cell GO:0030260 34 12 0,000 0,03488401 0,0621602 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03488401 0,06211489 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,03488401 0,06206965 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,03488401 0,06202448 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,03488401 0,06197937 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,03488401 0,06193433 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,03488401 0,06188935 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,03488401 0,06184444 ! snRNA metabolic process GO:0016073 30 12 0,000 0,03488401 0,06179959 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,03488401 0,06175481 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,03488401 0,06171009 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,03488401 0,06166544 ! cranial nerve development GO:0021545 23 12 0,000 0,03488401 0,06162085 ! fucose catabolic process GO:0019317 25 12 0,000 0,03488401 0,06157632 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,03488401 0,06153187 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,03488401 0,06148747 ! autonomic nervous system development GO:0048483 24 12 0,000 0,03488401 0,06144314 ! zymogen activation GO:0031638 18 12 0,000 0,03488401 0,06139887 ! T cell homeostasis GO:0043029 28 12 0,000 0,03488401 0,06135467 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,03488401 0,06131053 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,03488401 0,06126645 ! oocyte differentiation GO:0009994 21 12 0,000 0,03488401 0,06122244 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,03488401 0,06117849 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,03488401 0,0611346 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,03488401 0,06109078 GO:0042130|negative regulation of T cell proliferation, ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,03488401 0,06104702 ! defense response to fungus GO:0050832 15 12 0,000 0,03488401 0,06100332 ! developmental induction GO:0031128 22 12 0,000 0,03488401 0,06095968 GO:0045168|cell-cell signaling involved in cell fate specification, ! lamellipodium assembly GO:0030032 24 12 0,000 0,03488401 0,06091611 ! response to cold GO:0009409 17 12 0,000 0,03488401 0,0608726 ! establishment of cell polarity GO:0030010 21 12 0,000 0,03488401 0,06082915 ! regulation of synapse organization GO:0050807 18 12 0,000 0,03488401 0,06078576 ! localization within membrane GO:0051668 26 12 0,000 0,03488401 0,06074243 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,03547303 0,06172408 GO:0060538|skeletal muscle organ development, ! mRNA transport GO:0051028 185 100 1,000 0,03547303 0,06168015 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,03773601 0,06556832 ! cGMP metabolic process GO:0046068 18 13 0,000 0,03773601 0,06552172 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,03773601 0,06547519 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,03773601 0,06542872 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,03773601 0,06538231 ! peroxisomal transport GO:0043574 28 13 0,000 0,03773601 0,06533598 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,03773601 0,06528971 ! cartilage condensation GO:0001502 22 13 0,000 0,03773601 0,0652435 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,03773601 0,06519736 ! organelle fusion GO:0048284 36 13 0,000 0,03773601 0,06515128 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,03773601 0,06510527 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,03773601 0,06505933 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,03773601 0,06501344 ! endocrine pancreas development GO:0031018 25 13 0,000 0,03773601 0,06496763 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,03773601 0,06492188 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,03773601 0,06487619 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,03773601 0,06483057 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,03773601 0,06478501 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,03773601 0,06473951 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,03773601 0,06469408 ! methionine metabolic process GO:0006555 31 13 0,000 0,03773601 0,06464871 ! plasma membrane organization GO:0007009 27 13 0,000 0,03773601 0,06460341 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,03773601 0,06455817 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,03773601 0,06451299 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,03773601 0,06446788 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,03773601 0,06442283 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,03773601 0,06437784 ! exocrine system development GO:0035272 34 13 0,000 0,03773601 0,06433291 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,03773601 0,06428805 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,03773601 0,06424325 ! L-glutamate transport GO:0015813 30 13 0,000 0,03773601 0,06419851 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,03773601 0,06415384 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,03773601 0,06410922 ! protein homotetramerization GO:0051289 24 13 0,000 0,03773601 0,06406467 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,03773601 0,06402018 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,03773601 0,06397576 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,03773601 0,06393139 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,03773601 0,06388709 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,03773601 0,06384284 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,03773601 0,06379866 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,03773601 0,06375454 ! histone methylation GO:0016571 29 13 0,000 0,03773601 0,06371048 ! chromatin silencing GO:0006342 29 13 0,000 0,03773601 0,06366648 ! gland morphogenesis GO:0022612 31 13 0,000 0,03773601 0,06362254 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,03773601 0,06357866 ! regulation of epidermis development GO:0045682 19 13 0,000 0,03773601 0,06353485 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,03773601 0,06349109 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,03773601 0,06344739 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,03773601 0,06340376 ! spleen development GO:0048536 24 13 0,000 0,03773601 0,06336018 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,03773601 0,06331666 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,03773601 0,06327321 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,03773601 0,06322981 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,03773601 0,06318647 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,03773601 0,06314319 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,03773601 0,06309998 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,03773601 0,06305682 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,03773601 0,06301371 ! insulin secretion GO:0030073 24 13 0,000 0,03773601 0,06297067 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,03773601 0,06292769 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,03773601 0,06288476 ! acrosome reaction GO:0007340 19 13 0,000 0,03773601 0,0628419 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,03773601 0,06279909 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,03773601 0,06275634 ! rRNA transcription GO:0009303 28 14 0,000 0,04057966 0,06743952 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,04057966 0,06739368 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,04057966 0,06734789 ! water transport GO:0006833 21 14 0,000 0,04057966 0,06730217 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,04057966 0,06725651 ! non-recombinational repair GO:0000726 29 14 0,000 0,04057966 0,06721092 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,04057966 0,06716538 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,04057966 0,06711991 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,04057966 0,06707449 ! RNA polyadenylation GO:0043631 32 14 0,000 0,04057966 0,06702914 ! lipid localization GO:0010876 32 14 0,000 0,04057966 0,06698385 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,04057966 0,06693862 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,04057966 0,06689345 ! regulated secretory pathway GO:0045055 24 14 0,000 0,04057966 0,06684835 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,04057966 0,0668033 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,04057966 0,06675832 ! arginine metabolic process GO:0006525 21 14 0,000 0,04057966 0,06671339 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,04057966 0,06666853 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,04057966 0,06662372 ! regulation of heart rate GO:0002027 25 14 0,000 0,04057966 0,06657898 ! fear response GO:0042596 34 14 0,000 0,04057966 0,0665343 ! organic alcohol transport GO:0015850 29 14 0,000 0,04057966 0,06648967 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,04057966 0,06644511 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,04057966 0,0664006 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,04057966 0,06635616 ! neutral amino acid transport GO:0015804 28 14 0,000 0,04057966 0,06631177 ! bone mineralization GO:0030282 18 14 0,000 0,04057966 0,06626745 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,04057966 0,06622318 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,04057966 0,06617897 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,04057966 0,06613482 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,04057966 0,06609073 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,04057966 0,0660467 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,04057966 0,06600273 ! ribosome assembly GO:0042255 18 14 0,000 0,04057966 0,06595882 ! cerebellum development GO:0021549 23 14 0,000 0,04057966 0,06591496 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,04057966 0,06587116 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,04057966 0,06582742 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,04057966 0,06578374 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,04057966 0,06574012 ! NADP metabolic process GO:0006739 24 14 0,000 0,04057966 0,06569655 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,04057966 0,06565305 ! oxygen transport GO:0015671 22 14 0,000 0,04057966 0,0656096 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,04057966 0,0655662 ! regulation of axon extension GO:0030516 43 14 0,000 0,04057966 0,06552287 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,04057966 0,06547959 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,04057966 0,06543637 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,04341498 0,06996227 ! lactation GO:0007595 30 15 0,000 0,04341498 0,06991615 ! reproductive cellular process GO:0048610 22 15 0,000 0,04341498 0,06987009 ! tRNA modification GO:0006400 24 15 0,000 0,04341498 0,0698241 ! superoxide anion generation GO:0042554 22 15 0,000 0,04341498 0,06977816 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,04341498 0,06973228 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,04341498 0,06968647 ! copper ion transport GO:0006825 22 15 0,000 0,04341498 0,06964071 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,04341498 0,06959501 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,04341498 0,06954938 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,04341498 0,0695038 ! sulfate transport GO:0008272 27 15 0,000 0,04341498 0,06945829 ! response to cAMP GO:0051591 25 15 0,000 0,04341498 0,06941283 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,04341498 0,06936743 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,04341498 0,06932209 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,04341498 0,06927681 ! response to hexose stimulus GO:0009746 25 15 0,000 0,04341498 0,06923159 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,04341498 0,06918643 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,04341498 0,06914133 ! vesicle coating GO:0006901 38 15 0,000 0,04341498 0,06909629 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,04341498 0,0690513 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,04341498 0,06900638 ! regulation of exocytosis GO:0017157 26 15 0,000 0,04341498 0,06896151 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,04341498 0,0689167 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,04341498 0,06887195 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,04341498 0,06882726 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,04341498 0,06878262 ! regulation of vasodilation GO:0042312 27 15 0,000 0,04341498 0,06873804 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,04341498 0,06869352 ! histone deacetylation GO:0016575 24 15 0,000 0,04341498 0,06864906 ! water homeostasis GO:0030104 28 15 0,000 0,04341498 0,06860466 ! cofactor transport GO:0051181 30 15 0,000 0,04341498 0,06856031 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,04341498 0,06851602 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,04341498 0,06847179 ! intestinal absorption GO:0050892 31 15 0,000 0,04341498 0,06842761 ! dopamine metabolic process GO:0042417 35 15 0,000 0,04341498 0,0683835 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,04341498 0,06833943 ! heme biosynthetic process GO:0006783 33 15 0,000 0,04341498 0,06829543 ! cell killing GO:0001906 32 15 0,000 0,04341498 0,06825148 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,04341498 0,06820759 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,04341498 0,06816375 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,04341498 0,06811998 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,04341498 0,06807625 ! actin filament polymerization GO:0030041 27 15 0,000 0,04341498 0,06803259 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,04341498 0,06798898 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,04624201 0,07236978 ! positive regulation of cell size GO:0045793 29 16 0,000 0,04624201 0,07232345 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,04624201 0,07227718 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,04624201 0,07223096 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,04624201 0,07218481 ! bone remodeling GO:0046849 28 16 0,000 0,04624201 0,07213871 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,04624201 0,07209268 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,04624201 0,0720467 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04624201 0,07200078 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,04624201 0,07195492 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,04624201 0,07190912 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,04624201 0,07186338 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,04624201 0,07181769 ! startle response GO:0001964 28 16 0,000 0,04624201 0,07177206 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,04624201 0,07172649 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,04624201 0,07168098 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,04624201 0,07163553 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,04624201 0,07159013 ! protein polyubiquitination GO:0000209 41 16 0,000 0,04624201 0,07154479 ! glutamate metabolic process GO:0006536 25 16 0,000 0,04624201 0,07149951 ! pituitary gland development GO:0021983 30 16 0,000 0,04624201 0,07145429 ! response to osmotic stress GO:0006970 27 16 0,000 0,04624201 0,07140912 ! lysosomal transport GO:0007041 31 16 0,000 0,04624201 0,07136401 ! fructose metabolic process GO:0006000 25 16 0,000 0,04624201 0,07131896 ! L-amino acid transport GO:0015807 33 16 0,000 0,04624201 0,07127396 ! stem cell development GO:0048864 46 16 0,000 0,04624201 0,07122902 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,04624201 0,07118414 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,04624201 0,07113931 ! intermediate filament-based process GO:0045103 36 16 0,000 0,04624201 0,07109454 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,04624201 0,07104983 ! negative regulation of immune response GO:0050777 38 16 0,000 0,04624201 0,07100517 ! axon cargo transport GO:0008088 46 16 0,000 0,04624201 0,07096057 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,04624201 0,07091602 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,04624201 0,07087154 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,04624201 0,0708271 ! DNA replication initiation GO:0006270 28 16 0,000 0,04624201 0,07078272 ! neuron recognition GO:0008038 40 16 0,000 0,04624201 0,0707384 ! mRNA splice site selection GO:0006376 44 16 0,000 0,04624201 0,07069413 ! tissue regeneration GO:0042246 27 16 0,000 0,04624201 0,07064992 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,04624201 0,07060577 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,04624201 0,07056167 ! biomineral formation GO:0031214 22 16 0,000 0,04624201 0,07051762 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,04624201 0,07047363 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,04624201 0,07042969 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,04624201 0,07038581 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,04624201 0,07034198 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,04624201 0,07029821 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,04624201 0,07025449 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,04624201 0,07021083 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,04624201 0,07016722 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! peptide hormone processing GO:0016486 27 16 0,000 0,04624201 0,07012367 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,04906076 0,07435201 ! metencephalon development GO:0022037 32 17 0,000 0,04906076 0,07430591 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,04906076 0,07425987 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,04906076 0,07421389 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,04906076 0,07416797 ! signal complex assembly GO:0007172 47 17 0,000 0,04906076 0,0741221 ! filopodium assembly GO:0046847 42 17 0,000 0,04906076 0,07407629 ! endothelial cell migration GO:0043542 31 17 0,000 0,04906076 0,07403054 ! gene silencing by RNA GO:0031047 38 17 0,000 0,04906076 0,07398484 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,04906076 0,0739392 ! glial cell development GO:0021782 28 17 0,000 0,04906076 0,07389361 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,04906076 0,07384808 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,04906076 0,07380261 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,04906076 0,07375719 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,04906076 0,07371183 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,04906076 0,07366653 ! myoblast differentiation GO:0045445 50 17 0,000 0,04906076 0,07362128 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,04906076 0,07357608 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,04906076 0,07353094 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,04906076 0,07348586 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,04906076 0,07344083 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,04906076 0,07339586 ! NAD metabolic process GO:0019674 33 17 0,000 0,04906076 0,07335094 ! membrane budding GO:0006900 42 17 0,000 0,04906076 0,07330608 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,04906076 0,07326127 ! regulation of protein binding GO:0043393 33 17 0,000 0,04906076 0,07321652 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,04906076 0,07317182 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,04906076 0,07312717 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,04906076 0,07308258 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,04906076 0,07303805 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,04906076 0,07299357 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,04906076 0,07294914 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,04906076 0,07290477 ! steroid catabolic process GO:0006706 34 17 0,000 0,04906076 0,07286045 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,04906076 0,07281618 ! gas transport GO:0015669 26 17 0,000 0,04906076 0,07277197 ! organic cation transport GO:0015695 32 17 0,000 0,04906076 0,07272781 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,04906076 0,07268371 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,04906076 0,07263966 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,05187126 0,07675438 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,05187126 0,07670792 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,05187126 0,07666152 ! limbic system development GO:0021761 40 18 0,000 0,05187126 0,07661517 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,05187126 0,07656887 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,05187126 0,07652264 ! adult walking behavior GO:0007628 36 18 0,000 0,05187126 0,07647646 ! patterning of blood vessels GO:0001569 43 18 0,000 0,05187126 0,07643033 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,05187126 0,07638426 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,05187126 0,07633825 ! centrosome cycle GO:0007098 26 18 0,000 0,05187126 0,07629229 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,05187126 0,07624638 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,05187126 0,07620053 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,05187126 0,07615474 ! glycine metabolic process GO:0006544 30 18 0,000 0,05187126 0,076109 ! glutamine metabolic process GO:0006541 29 18 0,000 0,05187126 0,07606332 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,05187126 0,07601769 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,05187126 0,07597211 ! DNA integration GO:0015074 32 18 0,000 0,05187126 0,0759266 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,05187126 0,07588113 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,05187126 0,07583572 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,05187126 0,07579036 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,05187126 0,07574506 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,05187126 0,07569981 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,05187126 0,07565462 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,05187126 0,07560948 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,05187126 0,07556439 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,05187126 0,07551936 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,05187126 0,07547438 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,05187126 0,07542946 ! detection of bacterium GO:0016045 22 18 0,000 0,05187126 0,07538458 ! nerve development GO:0021675 34 18 0,000 0,05187126 0,07533977 ! defense response to virus GO:0051607 43 18 0,000 0,05187126 0,075295 ! microspike assembly GO:0030035 46 18 0,000 0,05187126 0,07525029 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,05187126 0,07520563 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,05467353 0,07922149 ! positive regulation of translation GO:0045727 31 19 0,000 0,05467353 0,07917453 ! negative regulation of defense response GO:0031348 27 19 0,000 0,05467353 0,07912763 ! neuron maturation GO:0042551 46 19 0,000 0,05467353 0,07908078 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,05467353 0,07903399 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,05467353 0,07898725 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,05467353 0,07894057 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,05467353 0,07889394 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,05467353 0,07884737 ! inositol metabolic process GO:0006020 33 19 0,000 0,05467353 0,07880085 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,05467353 0,07875439 ! memory GO:0007613 34 19 0,000 0,05467353 0,07870798 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,05467353 0,07866162 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,05467353 0,07861533 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,05467353 0,07856908 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,05467353 0,07852289 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,05467353 0,07847676 ! cerebral cortex development GO:0021987 40 19 0,000 0,05467353 0,07843067 ! pigmentation during development GO:0048066 42 19 0,000 0,05467353 0,07838465 ! heme metabolic process GO:0042168 40 19 0,000 0,05467353 0,07833867 ! neuromuscular junction development GO:0007528 43 19 0,000 0,05467353 0,07829275 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,05467353 0,07824689 ! response to fungus GO:0009620 26 19 0,000 0,05467353 0,07820108 ! peptide cross-linking GO:0018149 39 19 0,000 0,05467353 0,07815532 ! protein export from nucleus GO:0006611 40 19 0,000 0,05467353 0,07810961 ! heart process GO:0003015 32 19 0,000 0,05467353 0,07806396 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,05467353 0,07801836 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,05467353 0,07797282 ! visual learning GO:0008542 38 19 0,000 0,05467353 0,07792733 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,05467353 0,07788189 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,05467353 0,0778365 ! vitamin transport GO:0051180 31 19 0,000 0,05467353 0,07779117 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,05467353 0,07774589 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,05467353 0,07770066 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,05467353 0,07765549 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,05467353 0,07761036 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,05467353 0,07756529 ! cilium assembly GO:0042384 38 19 0,000 0,05467353 0,07752028 ! peptide hormone secretion GO:0030072 32 19 0,000 0,05467353 0,07747531 ! protein secretion GO:0009306 45 20 0,000 0,0574676 0,08138745 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,0574676 0,08134029 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,0574676 0,08129319 ! positive regulation of ossification GO:0045778 50 20 0,000 0,0574676 0,08124615 ! skin development GO:0043588 42 20 0,000 0,0574676 0,08119916 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 0,0574676 0,08115222 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,0574676 0,08110534 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,0574676 0,08105851 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,0574676 0,08101174 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,0574676 0,08096502 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,0574676 0,08091836 ! bile acid metabolic process GO:0008206 34 20 0,000 0,0574676 0,08087174 ! retinoid metabolic process GO:0001523 34 20 0,000 0,0574676 0,08082519 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,0574676 0,08077868 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,0574676 0,08073223 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,0574676 0,08068583 GO:0032392|DNA geometric change, ! actin filament bundle formation GO:0051017 47 20 0,000 0,0574676 0,08063949 ! body fluid secretion GO:0007589 33 20 0,000 0,0574676 0,0805932 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,0574676 0,08054696 ! peptide secretion GO:0002790 38 20 0,000 0,0574676 0,08050077 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,0574676 0,08045464 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,0574676 0,08040856 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,0574676 0,08036253 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,0574676 0,08031656 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,0574676 0,08027064 ! cell-cell junction organization GO:0045216 43 20 0,000 0,0574676 0,08022477 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,0574676 0,08017895 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,0574676 0,08013319 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,0574676 0,08008748 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,0574676 0,08004182 ! regulation of glucose import GO:0046324 30 20 0,000 0,0574676 0,07999621 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,0574676 0,07995065 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,0574676 0,07990515 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,0574676 0,0798597 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,0574676 0,0798143 ! regulation of cell killing GO:0031341 46 21 0,000 0,06025349 0,08363595 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,06025349 0,08358846 ! hormone secretion GO:0046879 39 21 0,000 0,06025349 0,08354102 ! lipid phosphorylation GO:0046834 43 21 0,000 0,06025349 0,08349363 ! cAMP metabolic process GO:0046058 41 21 0,000 0,06025349 0,0834463 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,06025349 0,08339902 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,06025349 0,0833518 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,06025349 0,08330462 ! ovarian follicle development GO:0001541 39 21 0,000 0,06025349 0,08325751 ! smooth muscle contraction GO:0006939 48 21 0,000 0,06025349 0,08321044 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,06025349 0,08316343 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,06025349 0,08311647 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,06025349 0,08306957 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,06025349 0,08302271 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,06025349 0,08297591 ! sensory perception of pain GO:0019233 33 21 0,000 0,06025349 0,08292917 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,06025349 0,08288247 ! diencephalon development GO:0021536 36 21 0,000 0,06025349 0,08283583 ! collagen fibril organization GO:0030199 62 21 0,000 0,06025349 0,08278924 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,06025349 0,08274271 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,06025349 0,08269622 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,06025349 0,08264979 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,06025349 0,08260341 ! collagen catabolic process GO:0030574 29 21 0,000 0,06025349 0,08255708 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,06025349 0,0825108 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,06025349 0,08246458 ! sperm-egg recognition GO:0035036 23 21 0,000 0,06025349 0,08241841 ! actin filament-based movement GO:0030048 47 21 0,000 0,06025349 0,08237228 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,06303122 0,08612152 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,06303122 0,08607338 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,06303122 0,08602529 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,06303122 0,08597726 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,06303122 0,08592928 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,06303122 0,08588136 ! microtubule-based transport GO:0010970 59 22 0,000 0,06303122 0,08583349 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,06303122 0,08578567 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,06303122 0,0857379 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,06303122 0,08569019 ! vacuolar transport GO:0007034 41 22 0,000 0,06303122 0,08564253 ! central nervous system neuron development GO:0021954 47 22 0,000 0,06303122 0,08559493 ! fucose metabolic process GO:0006004 44 22 0,000 0,06303122 0,08554737 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,06303122 0,08549987 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,06303122 0,08545243 ! ureteric bud development GO:0001657 50 22 0,000 0,06303122 0,08540503 ! stem cell differentiation GO:0048863 57 22 0,000 0,06303122 0,08535769 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,06303122 0,0853104 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,06303122 0,08526316 ! cytolysis GO:0019835 27 22 0,000 0,06303122 0,08521598 ! renal system process GO:0003014 42 22 0,000 0,06303122 0,08516885 ! vasodilation GO:0042311 40 22 0,000 0,06303122 0,08512176 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,06303122 0,08507474 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,06303122 0,08502776 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,06303122 0,08498083 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,06303122 0,08493396 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,06303122 0,08488714 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,06303122 0,08484037 ! sarcomere organization GO:0045214 32 22 0,000 0,06303122 0,08479365 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,06303122 0,08474699 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,06303122 0,08470037 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,06303122 0,08465381 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,06303122 0,08460729 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,06303122 0,08456083 ! gut development GO:0048565 44 22 0,000 0,06303122 0,08451442 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,06303122 0,08446806 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,06303122 0,08442175 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,06303122 0,08437549 ! protein stabilization GO:0050821 41 22 0,000 0,06303122 0,08432928 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,06580082 0,08798654 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,06580082 0,08793841 ! gluconeogenesis GO:0006094 38 23 0,000 0,06580082 0,08789033 ! glycerol metabolic process GO:0006071 40 23 0,000 0,06580082 0,0878423 ! viral genome replication GO:0019079 44 23 0,000 0,06580082 0,08779432 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,06580082 0,0877464 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,06580082 0,08769853 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,06580082 0,08765071 ! regeneration GO:0031099 42 23 0,000 0,06580082 0,08760295 ! axis specification GO:0009798 43 23 0,000 0,06580082 0,08755523 ! visual behavior GO:0007632 46 23 0,000 0,06580082 0,08750757 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,06580082 0,08745996 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,06580082 0,0874124 ! response to ethanol GO:0045471 47 23 0,000 0,06580082 0,08736489 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,06580082 0,08731744 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,06580082 0,08727003 ! peroxisome organization GO:0007031 43 23 0,000 0,06580082 0,08722268 ! lysosome organization GO:0007040 47 23 0,000 0,06580082 0,08717538 ! vesicle targeting GO:0006903 49 23 0,000 0,06580082 0,08712813 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,06580082 0,08708093 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,06580082 0,08703379 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,06580082 0,08698669 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,06580082 0,08693965 ! fatty acid transport GO:0015908 47 23 0,000 0,06580082 0,08689265 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,06580082 0,08684571 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,06580082 0,08679881 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,06580082 0,08675197 ! hormone transport GO:0009914 41 23 0,000 0,06580082 0,08670518 ! cell-cell recognition GO:0009988 28 23 0,000 0,06580082 0,08665844 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,06580082 0,08661175 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,06580082 0,08656511 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,06580082 0,08651852 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,06856231 0,09010098 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,06856231 0,09005254 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,06856231 0,09000415 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,06856231 0,08995581 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,06856231 0,08990753 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,06856231 0,0898593 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,06856231 0,08981111 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,06856231 0,08976298 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 0,000 0,06856231 0,0897149 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,06856231 0,08966688 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,06856231 0,0896189 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,06856231 0,08957098 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,06856231 0,0895231 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,06856231 0,08947528 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,06856231 0,08942751 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,06856231 0,08937979 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,06856231 0,08933212 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 52 24 0,000 0,06856231 0,0892845 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,06856231 0,08923693 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,06856231 0,08918942 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,06856231 0,08914195 ! membrane depolarization GO:0051899 45 24 0,000 0,06856231 0,08909454 ! pallium development GO:0021543 56 24 0,000 0,06856231 0,08904717 ! oogenesis GO:0048477 44 24 0,000 0,06856231 0,08899985 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,06856231 0,08895259 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,06856231 0,08890537 ! platelet activation GO:0030168 41 24 0,000 0,06856231 0,08885821 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,06856231 0,0888111 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,06856231 0,08876403 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,06856231 0,08871702 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,06856231 0,08867005 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,06856231 0,08862314 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,06856231 0,08857627 ! regulation of amine transport GO:0051952 41 24 0,000 0,06856231 0,08852945 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,07131572 0,09203608 ! leukocyte adhesion GO:0007159 55 25 0,000 0,07131572 0,09198748 ! phototransduction GO:0007602 37 25 0,000 0,07131572 0,09193894 ! vacuole organization GO:0007033 49 25 0,000 0,07131572 0,09189045 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,07131572 0,09184201 ! receptor metabolic process GO:0043112 53 25 0,000 0,07131572 0,09179362 ! chromosome condensation GO:0030261 48 25 0,000 0,07131572 0,09174528 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,07131572 0,091697 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,07131572 0,09164876 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,07131572 0,09160058 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,07131572 0,09155244 ! immunoglobulin production GO:0002377 62 25 0,000 0,07131572 0,09150436 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,07131572 0,09145632 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,07131572 0,09140834 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,07131572 0,09136041 ! liver development GO:0001889 55 25 0,000 0,07131572 0,09131252 ! myelination GO:0042552 50 26 0,000 0,07406106 0,09477798 ! initiation of viral infection GO:0019059 60 26 0,000 0,07406106 0,09472836 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,07406106 0,09467879 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,07406106 0,09462927 ! molting cycle process GO:0022404 52 26 0,000 0,07406106 0,09457981 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,07406106 0,09453039 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,07406106 0,09448103 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,07406106 0,09443172 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,07406106 0,09438246 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,07406106 0,09433325 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,07406106 0,09428409 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,07406106 0,09423498 ! digestive system process GO:0022600 49 26 0,000 0,07406106 0,09418593 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,07406106 0,09413692 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 0,000 0,07406106 0,09408797 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,07406106 0,09403907 ! osteoblast differentiation GO:0001649 63 26 0,000 0,07406106 0,09399022 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,07406106 0,09394142 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,07406106 0,09389267 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,07406106 0,09384397 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,07406106 0,09379532 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,07406106 0,09374672 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,07406106 0,09369817 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,07406106 0,09364967 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,07406106 0,09360123 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,07406106 0,09355283 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,07406106 0,09350448 ! blastocyst development GO:0001824 50 26 0,000 0,07406106 0,09345618 ! telomere organization GO:0032200 46 26 0,000 0,07406106 0,09340793 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,07406106 0,09335974 ! neural tube closure GO:0001843 58 26 0,000 0,07406106 0,09331159 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,07406106 0,09326349 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,07406106 0,09321544 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,07406106 0,09316744 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,07679836 0,0965612 ! embryonic pattern specification GO:0009880 49 27 0,000 0,07679836 0,09651153 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,07679836 0,0964619 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,07679836 0,09641234 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,07679836 0,09636282 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,07679836 0,09631335 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,07679836 0,09626393 ! iron ion transport GO:0006826 65 27 0,000 0,07679836 0,09621457 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,07679836 0,09616525 ! superoxide metabolic process GO:0006801 41 27 0,000 0,07679836 0,09611599 ! tube lumen formation GO:0035148 59 27 0,000 0,07679836 0,09606677 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,07679836 0,09601761 ! response to toxin GO:0009636 49 27 0,000 0,07679836 0,09596849 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,07679836 0,09591943 ! leukocyte proliferation GO:0070661 59 27 0,000 0,07679836 0,09587042 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,07679836 0,09582145 ! neuron fate commitment GO:0048663 52 28 0,000 0,07952765 0,09917614 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,07952765 0,09912554 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,07952765 0,09907499 ! vesicle docking GO:0048278 55 28 0,000 0,07952765 0,09902449 ! circadian rhythm GO:0007623 56 28 0,000 0,07952765 0,09897405 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,07952765 0,09892366 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,07952765 0,09887331 ! sperm motility GO:0030317 37 28 0,000 0,07952765 0,09882302 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,07952765 0,09877278 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,07952765 0,09872259 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,07952765 0,09867245 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,07952765 0,09862236 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,07952765 0,09857233 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,07952765 0,09852234 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,07952765 0,09847241 ! glutathione metabolic process GO:0006749 42 28 0,000 0,07952765 0,09842252 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,07952765 0,09837269 ! lipid oxidation GO:0034440 48 28 0,000 0,07952765 0,0983229 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,07952765 0,09827317 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,07952765 0,09822349 ! translational initiation GO:0006413 66 29 0,000 0,08224895 0,10153319 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,08224895 0,10148191 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,08224895 0,10143069 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,08224895 0,10137951 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,08224895 0,10132839 ! primary neural tube formation GO:0014020 61 29 0,000 0,08224895 0,10127731 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,08224895 0,10122629 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,08224895 0,10117532 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,08224895 0,1011244 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,08224895 0,10107354 ! synaptogenesis GO:0007416 46 29 0,000 0,08224895 0,10102272 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,08224895 0,10097195 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,08224895 0,10092124 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,08224895 0,10087058 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,08224895 0,10081996 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,08496228 0,10409371 ! phenol metabolic process GO:0018958 56 30 0,000 0,08496228 0,10404153 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,08496228 0,1039894 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,08496228 0,10393733 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,08496228 0,10388531 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,08496228 0,10383334 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,08496228 0,10378142 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,08496228 0,10372956 ! acute-phase response GO:0006953 50 30 0,000 0,08496228 0,10367775 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,08496228 0,10362599 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,08496228 0,10357428 ! myofibril assembly GO:0030239 50 30 0,000 0,08496228 0,10352262 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,08496228 0,10347101 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,08496228 0,10341946 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,08496228 0,10336795 ! cell fate determination GO:0001709 64 30 0,000 0,08496228 0,1033165 ! phospholipid transport GO:0015914 65 30 0,000 0,08496228 0,1032651 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,08496228 0,10321375 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,08496228 0,10316245 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,08496228 0,1031112 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,08496228 0,10306 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,08496228 0,10300886 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,08496228 0,10295776 ! regulation of coagulation GO:0050818 52 30 0,000 0,08496228 0,10290672 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,08766766 0,10613087 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,08766766 0,10607831 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,08766766 0,10602579 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,08766766 0,10597333 ! cell junction assembly GO:0034329 85 31 0,000 0,08766766 0,10592092 ! regulation of innate immune response GO:0045088 57 31 0,000 0,08766766 0,10586856 ! ovulation cycle process GO:0022602 55 31 0,000 0,08766766 0,10581625 ! peptide transport GO:0015833 60 31 0,000 0,08766766 0,105764 ! male gonad development GO:0008584 56 31 0,000 0,08766766 0,1057118 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,08766766 0,10565964 ! detection of light stimulus GO:0009583 44 31 0,000 0,08766766 0,10560754 ! natural killer cell activation GO:0030101 50 31 0,000 0,08766766 0,1055555 ! ensheathment of neurons GO:0007272 64 31 0,000 0,08766766 0,1055035 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,08766766 0,10545155 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,08766766 0,10539966 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,08766766 0,10534781 ! eye morphogenesis GO:0048592 65 31 0,000 0,08766766 0,10529602 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,08766766 0,10524427 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,09036512 0,10842927 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,09036512 0,10837604 ! spindle organization GO:0007051 50 32 0,000 0,09036512 0,10832286 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,09036512 0,10826974 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,09036512 0,10821666 ! metanephros development GO:0001656 81 32 0,000 0,09036512 0,10816364 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,09036512 0,10811067 ! muscle cell development GO:0055001 52 32 0,000 0,09036512 0,10805776 ! mesoderm formation GO:0001707 73 32 0,000 0,09036512 0,10800489 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,09036512 0,10795208 ! ovulation cycle GO:0042698 57 32 0,000 0,09036512 0,10789931 ! peripheral nervous system development GO:0007422 68 32 0,000 0,09036512 0,1078466 ! BMP signaling pathway GO:0030509 71 32 0,000 0,09036512 0,10779394 ! hindbrain development GO:0030902 65 32 0,000 0,09036512 0,10774133 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,09036512 0,10768878 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,09036512 0,10763627 ! gene silencing GO:0016458 71 32 0,000 0,09036512 0,10758382 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,09305468 0,1107319 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,09305468 0,11067799 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,09305468 0,11062413 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,09305468 0,11057033 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,09305468 0,11051657 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,09305468 0,11046287 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,09305468 0,11040922 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,09305468 0,11035563 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,09305468 0,11030208 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,09305468 0,11024859 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,09305468 0,11019515 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,09305468 0,11014176 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,09573637 0,11326099 ! glial cell differentiation GO:0010001 67 34 0,000 0,09573637 0,11320617 ! post-embryonic development GO:0009791 76 34 0,000 0,09573637 0,1131514 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,09573637 0,11309668 ! cholesterol transport GO:0030301 62 34 0,000 0,09573637 0,11304202 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,09573637 0,11298741 ! spliceosome assembly GO:0000245 75 34 0,000 0,09573637 0,11293285 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,09573637 0,11287835 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,09573637 0,1128239 ! formation of primary germ layer GO:0001704 76 34 0,000 0,09573637 0,1127695 ! cell fate specification GO:0001708 56 34 0,000 0,09573637 0,11271515 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,09573637 0,11266086 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,09573637 0,11260662 ! adult locomotory behavior GO:0008344 62 34 0,000 0,09573637 0,11255243 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,0984102 0,11564026 ! negative regulation of secretion GO:0051048 68 35 0,000 0,0984102 0,11558467 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,0984102 0,11552912 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,0984102 0,11547363 ! membrane docking GO:0022406 69 35 0,000 0,0984102 0,1154182 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,0984102 0,11536282 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,0984102 0,11530749 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,0984102 0,11525221 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,0984102 0,11519698 ! ceramide metabolic process GO:0006672 72 35 0,000 0,0984102 0,11514181 ! telencephalon development GO:0021537 81 35 0,000 0,0984102 0,1150867 ! sterol transport GO:0015918 63 35 0,000 0,0984102 0,11503163 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,0984102 0,11497662 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,0984102 0,11492166 ! vesicle localization GO:0051648 70 35 0,000 0,0984102 0,11486675 ! regulation of muscle development GO:0048634 82 36 0,000 0,10107619 0,11792223 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,10107619 0,11786594 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,10107619 0,1178097 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,10107619 0,11775352 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,10107619 0,1176974 ! positive regulation of cell development GO:0010720 85 36 0,000 0,10107619 0,11764132 ! protein targeting to membrane GO:0006612 75 36 0,000 0,10107619 0,11758531 ! regulation of proteolysis GO:0030162 77 36 0,000 0,10107619 0,11752934 ! aerobic respiration GO:0009060 56 36 0,000 0,10107619 0,11747343 ! cytokine production GO:0001816 68 36 0,000 0,10107619 0,11741757 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,10107619 0,11736176 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,10107619 0,11730601 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,10373438 0,12033385 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,10373438 0,12027674 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,10373438 0,12021969 ! sister chromatid segregation GO:0000819 65 37 0,000 0,10373438 0,12016268 ! actomyosin structure organization GO:0031032 68 37 0,000 0,10373438 0,12010573 ! cell junction organization GO:0034330 96 37 0,000 0,10373438 0,12004884 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,10373438 0,119992 ! female gonad development GO:0008585 71 37 0,000 0,10373438 0,11993521 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,10373438 0,11987848 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,10373438 0,1198218 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,10373438 0,11976517 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,10638479 0,12276714 ! meiosis I GO:0007127 74 38 0,000 0,10638479 0,12270918 ! organic anion transport GO:0015711 82 38 0,000 0,10638479 0,12265127 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,10638479 0,12259341 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,10638479 0,12253561 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,10638479 0,12247787 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,10638479 0,12242018 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,10638479 0,12236254 ! regulation of protein stability GO:0031647 77 38 0,000 0,10638479 0,12230496 ! spermatid development GO:0007286 69 38 0,000 0,10638479 0,12224743 ! pigment metabolic process GO:0042440 87 38 0,000 0,10638479 0,12218996 ! neural tube formation GO:0001841 79 38 0,000 0,10638479 0,12213254 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,10902743 0,12510757 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,10902743 0,12504883 ! negative regulation of binding GO:0051100 71 39 0,000 0,10902743 0,12499015 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,10902743 0,12493152 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,10902743 0,12487295 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,10902743 0,12481444 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,10902743 0,12475597 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,10902743 0,12469757 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,10902743 0,12463922 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,11166233 0,12759171 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,11166233 0,12753206 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,11166233 0,12747246 ! learning GO:0007612 82 40 0,000 0,11166233 0,12741292 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,11166233 0,12735344 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,11166233 0,12729401 ! mismatch repair GO:0006298 58 40 0,000 0,11166233 0,12723464 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,11166233 0,12717532 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,11166233 0,12711606 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,11166233 0,12705685 ! RNA export from nucleus GO:0006405 61 41 0,000 0,11428951 0,12998569 ! mRNA catabolic process GO:0006402 79 41 0,000 0,11428951 0,12992521 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,11428951 0,12986478 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,11428951 0,1298044 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,11428951 0,12974409 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,11428951 0,12968382 ! gliogenesis GO:0042063 91 41 0,000 0,11428951 0,12962362 ! feeding behavior GO:0007631 69 41 0,000 0,11428951 0,12956347 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,11428951 0,12950337 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,11428951 0,12944333 ! spermatid differentiation GO:0048515 73 41 0,000 0,11428951 0,12938335 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,11428951 0,12932342 ! RNA modification GO:0009451 64 41 0,000 0,11428951 0,12926355 ! organic ether metabolic process GO:0018904 59 42 0,000 0,11690899 0,13216505 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,11690899 0,13210392 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,11690899 0,13204285 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,11690899 0,13198183 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,11690899 0,13192087 ! regulation of protein secretion GO:0050708 77 42 0,000 0,11690899 0,13185996 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,11690899 0,13179911 ! cytokinesis GO:0000910 84 42 0,000 0,11690899 0,13173832 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,11690899 0,13167758 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,11952081 0,1345573 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,11952081 0,13449532 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,11952081 0,13443339 ! regulation of tube size GO:0035150 76 43 0,000 0,11952081 0,13437153 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,11952081 0,13430972 ! glucose transport GO:0015758 66 43 0,000 0,11952081 0,13424797 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,11952081 0,13418627 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,11952081 0,13412464 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,11952081 0,13406305 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,11952081 0,13400153 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,11952081 0,13394006 ! ion transmembrane transport GO:0034220 79 43 0,000 0,11952081 0,13387865 ! neuron migration GO:0001764 85 43 0,000 0,11952081 0,13381729 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,12212497 0,13667031 ! hexose transport GO:0008645 68 44 0,000 0,12212497 0,13660774 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,12212497 0,13654522 ! striated muscle contraction GO:0006941 85 44 0,000 0,12212497 0,13648275 ! phagocytosis GO:0006909 105 44 0,000 0,12212497 0,13642035 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,12212497 0,136358 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,1247215 0,13919352 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,1247215 0,13912997 ! regulation of epithelial cell proliferation GO:0050678 122 45 0,000 0,1247215 0,13906646 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,1247215 0,13900302 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,1247215 0,13893964 ! female gamete generation GO:0007292 71 45 0,000 0,1247215 0,13887631 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,1247215 0,13881304 ! polyol metabolic process GO:0019751 77 45 0,000 0,1247215 0,13874983 ! developmental growth GO:0048589 88 45 0,000 0,1247215 0,13868667 ! maintenance of location in cell GO:0051651 101 45 0,000 0,1247215 0,13862358 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,12731042 0,14143673 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,12731042 0,14137244 ! glycolysis GO:0006096 71 46 0,000 0,12731042 0,14130821 ! leukocyte migration GO:0050900 75 46 0,000 0,12731042 0,14124404 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,12731042 0,14117992 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,12731042 0,14111587 ! cell growth GO:0016049 90 46 0,000 0,12731042 0,14105187 ! neural tube development GO:0021915 91 47 0,000 0,12989176 0,14384659 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,12989176 0,14378141 ! positive regulation of defense response GO:0031349 88 48 0,000 0,13246554 0,146564 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,13246554 0,14649765 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,13246554 0,14643137 ! endosome transport GO:0016197 127 48 0,000 0,13246554 0,14636514 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,13246554 0,14629897 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,13246554 0,14623286 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,13246554 0,14616681 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,13503178 0,14893121 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,13503178 0,148864 ! JNK cascade GO:0007254 106 49 0,000 0,13503178 0,14879686 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,13503178 0,14872977 ! protein homooligomerization GO:0051260 84 49 0,000 0,13503178 0,14866275 ! regulation of action potential GO:0001508 102 50 0,000 0,13759049 0,15141152 ! regulation of ion transport GO:0043269 86 50 0,000 0,13759049 0,15134335 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,13759049 0,15127524 ! endocrine system development GO:0035270 109 50 0,000 0,13759049 0,15120719 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,13759049 0,1511392 ! regulation of ossification GO:0030278 123 50 0,000 0,13759049 0,15107127 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,13759049 0,1510034 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,13759049 0,1509356 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,14014171 0,15366526 ! viral infectious cycle GO:0019058 104 51 0,000 0,14014171 0,15359633 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,14014171 0,15352745 ! peptide metabolic process GO:0006518 80 51 0,000 0,14014171 0,15345863 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,14014171 0,15338988 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,14268546 0,15610415 ! Notch signaling pathway GO:0007219 111 52 0,000 0,14268546 0,15603428 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,14268546 0,15596446 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,14268546 0,15589471 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,14268546 0,15582502 ! excretion GO:0007588 87 52 0,000 0,14268546 0,1557554 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,14268546 0,15568583 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,14268546 0,15561633 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,14268546 0,15554689 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,14268546 0,15547751 ! respiratory electron transport chain GO:0022904 83 53 0,000 0,14522175 0,15817064 ! inner ear development GO:0048839 89 53 0,000 0,14522175 0,15810015 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,14522175 0,15802973 ! vesicle organization GO:0016050 127 53 0,000 0,14522175 0,15795937 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,14522175 0,15788907 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! synapse organization GO:0050808 102 53 0,000 0,14522175 0,15781883 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,14775061 0,16049566 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,14775061 0,16042433 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,14775061 0,16035306 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,14775061 0,16028185 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,14775061 0,16021071 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,14775061 0,16013963 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,14775061 0,16006862 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,14775061 0,15999767 ! RNA catabolic process GO:0006401 103 55 0,000 0,15027206 0,16265602 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,15027206 0,16258398 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,15027206 0,16251201 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,15027206 0,1624401 ! cell recognition GO:0008037 98 55 0,000 0,15027206 0,16236826 ! cell maturation GO:0048469 107 55 0,000 0,15027206 0,16229648 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,15027206 0,16222476 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,15278612 0,16486594 ! glucose catabolic process GO:0006007 88 56 0,000 0,15278612 0,16479315 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,15278612 0,16472042 ! RNA elongation GO:0006354 90 56 0,000 0,15278612 0,16464776 ! chloride transport GO:0006821 102 57 0,000 0,15529281 0,16727528 ! muscle fiber development GO:0048747 131 57 0,000 0,15529281 0,16720155 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,15529281 0,1671279 ! regulation of actin filament length GO:0030832 118 58 0,000 0,15779215 0,16974294 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,15779215 0,16966823 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,15779215 0,16959359 ! gastrulation GO:0007369 122 58 0,000 0,15779215 0,16951901 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,15779215 0,16944449 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,15779215 0,16937005 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,15779215 0,16929566 ! maintenance of location GO:0051235 124 58 0,000 0,15779215 0,16922135 ! nuclear export GO:0051168 110 59 0,000 0,16028417 0,17181844 ! establishment of organelle localization GO:0051656 122 59 0,000 0,16028417 0,17174308 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,16276889 0,17432898 ! lipid modification GO:0030258 112 60 0,000 0,16276889 0,17425258 ! regulation of endocytosis GO:0030100 104 60 0,000 0,16276889 0,17417626 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,16276889 0,1741 ! adult behavior GO:0030534 104 60 0,000 0,16276889 0,1740238 ! kidney development GO:0001822 133 60 0,000 0,16276889 0,17394768 ! positive regulation of secretion GO:0051047 110 61 0,000 0,16524632 0,17651804 ! regulation of cellular component size GO:0032535 125 61 0,000 0,16524632 0,17644089 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,16524632 0,17636381 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,16524632 0,1762868 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,16524632 0,17620985 ! regulation of heart contraction GO:0008016 123 61 0,000 0,16524632 0,17613297 ! camera-type eye development GO:0043010 126 61 0,000 0,16524632 0,17605616 ! proton transport GO:0015992 117 61 0,000 0,16524632 0,17597941 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,16524632 0,17590273 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,16771649 0,17845444 ! tRNA processing GO:0008033 102 62 0,000 0,16771649 0,17837675 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,17017943 0,18091747 ! regulation of mitosis GO:0007088 112 63 0,000 0,17017943 0,18083877 GO:0051783|regulation of nuclear division, ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,17017943 0,18076015 ! hydrogen transport GO:0006818 121 64 0,000 0,17263514 0,18328885 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,17263514 0,18320923 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,17263514 0,18312968 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,17508365 0,18564643 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,17508365 0,18556589 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,17508365 0,18548542 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,17508365 0,18540501 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,17508365 0,18532468 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,17752499 0,18782744 ! gonad development GO:0008406 115 66 0,000 0,17752499 0,18774613 ! steroid hormone receptor signaling pathway GO:0030518 146 66 0,000 0,17752499 0,18766489 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,17995917 0,19015582 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,17995917 0,19007361 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,17995917 0,18999147 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,17995917 0,1899094 ! secondary metabolic process GO:0019748 125 67 0,000 0,17995917 0,1898274 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,18238622 0,1923045 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,18238622 0,19222154 ! hexose catabolic process GO:0019320 113 68 0,000 0,18238622 0,19213865 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,18238622 0,19205583 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,18238622 0,19197309 ! regulation of lipase activity GO:0060191 137 68 0,000 0,18238622 0,19189041 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,18238622 0,19180781 ! cell projection assembly GO:0030031 138 68 0,000 0,18238622 0,19172527 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,18480615 0,19418556 ! negative regulation of protein kinase activity GO:0006469 144 69 0,000 0,18480615 0,19410207 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,18480615 0,19401866 ! urogenital system development GO:0001655 149 69 0,000 0,18480615 0,19393532 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,18480615 0,19385205 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,18480615 0,19376885 ! developmental maturation GO:0021700 128 69 0,000 0,18480615 0,19368572 ! single fertilization GO:0007338 83 69 0,000 0,18480615 0,19360267 ! negative regulation of kinase activity GO:0033673 145 70 0,000 0,18721899 0,19604628 ! cell redox homeostasis GO:0045454 114 70 0,000 0,18721899 0,19596229 ! germ cell development GO:0007281 133 70 0,000 0,18721899 0,19587836 ! activation of immune response GO:0002253 120 70 0,000 0,18721899 0,19579451 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,18721899 0,19571073 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,18962475 0,19814083 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,18962475 0,19805612 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 0,000 0,18962475 0,19797148 ! appendage morphogenesis GO:0035107 150 72 0,000 0,19202346 0,20039013 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,19202346 0,20030457 ! actin filament organization GO:0007015 167 72 0,000 0,19202346 0,20021908 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,19202346 0,20013366 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,19202346 0,20004832 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,19202346 0,19996304 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,19202346 0,19987785 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,19202346 0,19979272 ! appendage development GO:0048736 151 73 0,000 0,19441513 0,20219505 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,19441513 0,20210901 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,19441513 0,20202304 ! regulation of immune effector process GO:0002697 156 73 0,000 0,19441513 0,20193715 ! acute inflammatory response GO:0002526 118 74 0,000 0,1967998 0,2043272 ! amino acid transport GO:0006865 148 74 0,000 0,1967998 0,2042404 ! negative regulation of transferase activity GO:0051348 155 74 0,000 0,1967998 0,20415367 ! organelle localization GO:0051640 155 74 0,000 0,1967998 0,20406702 ! transition metal ion transport GO:0000041 143 75 0,000 0,19917747 0,20644487 ! reproductive structure development GO:0048608 131 75 0,000 0,19917747 0,20635732 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,19917747 0,20626984 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,19917747 0,20618244 ! eye development GO:0001654 155 75 0,000 0,19917747 0,20609511 ! axon guidance GO:0007411 162 75 0,000 0,19917747 0,20600786 ! rhythmic process GO:0048511 142 75 0,000 0,19917747 0,20592067 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,20154817 0,20828349 ! learning or memory GO:0007611 161 76 0,000 0,20154817 0,20819542 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,20154817 0,20810743 ! regulation of blood pressure GO:0008217 134 76 0,000 0,20154817 0,20801951 ! amine catabolic process GO:0009310 136 77 0,000 0,20391192 0,21037028 ! neurotransmitter transport GO:0006836 142 77 0,000 0,20391192 0,21028147 ! phosphoinositide metabolic process GO:0030384 146 77 0,000 0,20391192 0,21019275 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,20391192 0,2101041 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,20391192 0,21001552 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,20391192 0,20992702 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,20391192 0,20983859 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,20626873 0,21217453 ! antigen processing and presentation GO:0019882 117 78 0,000 0,20626873 0,21208524 ! fertilization GO:0009566 99 78 0,000 0,20626873 0,21199601 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,20626873 0,21190686 ! blood coagulation GO:0007596 151 79 0,000 0,20861864 0,21423091 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,20861864 0,2141409 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,20861864 0,21405096 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,20861864 0,2139611 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,20861864 0,21387131 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,20861864 0,2137816 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,21096166 0,21609196 ! meiosis GO:0007126 143 81 0,000 0,2132978 0,21839335 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 0,000 0,2132978 0,21830185 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,2132978 0,21821044 ! meiotic cell cycle GO:0051321 144 82 0,000 0,21562709 0,22050104 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,21794956 0,22278275 ! exocytosis GO:0006887 153 83 0,000 0,21794956 0,22268957 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,21794956 0,22259647 ! inorganic anion transport GO:0015698 156 83 0,000 0,21794956 0,22250345 ! digestion GO:0007586 130 84 0,000 0,22026521 0,22477356 ! regulation of ligase activity GO:0051340 147 84 0,000 0,22026521 0,22467971 ! hemostasis GO:0007599 165 85 0,000 0,22257407 0,22694009 ! negative regulation of transport GO:0051051 164 85 0,000 0,22257407 0,22684541 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,22257407 0,22675081 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,22257407 0,22665629 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,22257407 0,22656185 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,22257407 0,22646749 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,22487615 0,22871459 ! regulation of lyase activity GO:0051339 169 86 0,000 0,22487615 0,22861941 ! positive regulation of cell activation GO:0050867 161 86 0,000 0,22487615 0,22852431 GO:0002696|positive regulation of leukocyte activation, ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,22717149 0,23076089 ! alcohol catabolic process GO:0046164 142 87 0,000 0,22717149 0,23066498 ! nucleosome assembly GO:0006334 126 87 0,000 0,22717149 0,23056915 ! cellular respiration GO:0045333 143 88 0,000 0,22946009 0,23279527 ! amine biosynthetic process GO:0009309 146 88 0,000 0,22946009 0,23269863 ! sensory perception of smell GO:0007608 117 88 0,000 0,22946009 0,23260208 ! chromatin assembly GO:0031497 128 88 0,000 0,22946009 0,2325056 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,23174198 0,23472042 ! tube morphogenesis GO:0035239 194 89 0,000 0,23174198 0,23462315 ! cellular defense response GO:0006968 123 89 0,000 0,23174198 0,23452596 ! regulation of neurological system process GO:0031644 175 89 0,000 0,23174198 0,23442885 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,23401718 0,23663244 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,23401718 0,23653453 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,2362857 0,23872869 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,2362857 0,23863 ! gland development GO:0048732 220 91 0,000 0,2362857 0,23853139 ! defense response to bacterium GO:0042742 112 91 0,000 0,2362857 0,23843287 ! bone development GO:0060348 206 92 0,000 0,23854757 0,2406159 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,23854757 0,2405166 ! regulation of cell adhesion GO:0030155 241 92 0,000 0,23854757 0,24041737 ! amine transport GO:0015837 181 93 0,000 0,2408028 0,2425902 ! vitamin metabolic process GO:0006766 153 93 0,000 0,2408028 0,24249021 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,24305142 0,24465374 ! female pregnancy GO:0007565 166 94 0,000 0,24305142 0,24455297 ! sterol metabolic process GO:0016125 166 94 0,000 0,24305142 0,24445229 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,24305142 0,24435169 ! regulation of membrane potential GO:0042391 179 94 0,000 0,24305142 0,24425118 ! regulation of defense response GO:0031347 171 95 0,000 0,24529344 0,24640291 ! nucleosome organization GO:0034728 143 95 0,000 0,24529344 0,24630163 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,24529344 0,24620044 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,24529344 0,24609933 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,24529344 0,2459983 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,24529344 0,24589736 ! regulation of T cell activation GO:0050863 175 96 0,000 0,24752888 0,24803653 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,24975776 0,25016737 ! forebrain development GO:0030900 210 98 0,000 0,25198011 0,25228992 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,25198011 0,25218656 ! positive regulation of immune response GO:0050778 175 100 0,000 0,25640525 0,25651025 ! hormone metabolic process GO:0042445 171 100 0,000 0,25640525 0,25640525