pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/549-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! insulin receptor signaling pathway GO:0008286 66 27 5,000 4,9E-10 1,197E-06 ! cellular response to insulin stimulus GO:0032869 85 38 5,000 4,427E-09 5,407E-06 ! regulation of lipid kinase activity GO:0043550 17 8 3,000 1,042E-08 8,487E-06 ! response to insulin stimulus GO:0032868 98 47 5,000 1,678E-08 1,025E-05 ! response to peptide hormone stimulus GO:0043434 129 64 5,000 1,115E-07 5,448E-05 ! cellular response to hormone stimulus GO:0032870 182 85 5,000 6,122E-07 2,493E-04 ! regulation of DNA binding GO:0051101 167 89 5,000 8,04E-07 2,806E-04 ! nuclear migration GO:0007097 13 6 2,000 8,631E-07 2,636E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 8,631E-07 2,343E-04 GO:0031272|regulation of pseudopodium assembly, ! protein import into nucleus, translocation GO:0000060 51 25 3,000 1,797E-06 4,391E-04 ! maintenance of location GO:0051235 124 58 4,000 2,037E-06 4,524E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 2,404E-06 4,895E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 2,404E-06 4,518E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 3,597E-06 6,277E-04 ! macrophage differentiation GO:0030225 15 9 2,000 3,597E-06 5,858E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 2,000 5,125E-06 7,826E-04 ! sequestering of metal ion GO:0051238 15 11 2,000 7,029E-06 1,01E-03 ! nucleus localization GO:0051647 22 11 2,000 7,029E-06 9,54E-04 ! regulation of cell projection assembly GO:0060491 33 12 2,000 9,348E-06 1,202E-03 ! protein import into nucleus GO:0006606 174 82 4,000 1,133E-05 1,384E-03 ! nuclear import GO:0051170 177 83 4,000 1,203E-05 1,399E-03 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 1,539E-05 1,709E-03 ! protein localization in nucleus GO:0034504 192 89 4,000 1,69E-05 1,795E-03 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 2,000 1,918E-05 1,953E-03 ! induction of apoptosis by intracellular signals GO:0008629 95 45 3,000 2,004E-05 1,958E-03 ! maintenance of location in cell GO:0051651 101 45 3,000 2,004E-05 1,883E-03 ! regulation of gene-specific transcription GO:0032583 102 46 3,000 2,189E-05 1,981E-03 ! regulation of DNA metabolic process GO:0051052 188 97 4,000 2,566E-05 2,239E-03 ! positive regulation of DNA binding GO:0043388 83 48 3,000 2,596E-05 2,187E-03 ! leukocyte differentiation GO:0002521 232 98 4,000 2,696E-05 2,196E-03 ! filopodium assembly GO:0046847 42 17 2,000 2,852E-05 2,248E-03 ! microspike assembly GO:0030035 46 18 2,000 3,414E-05 2,606E-03 ! positive regulation of binding GO:0051099 88 52 3,000 3,572E-05 2,645E-03 ! response to lipopolysaccharide GO:0032496 34 19 2,000 4,043E-05 2,905E-03 ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 4,744E-05 3,312E-03 ! regulation of DNA replication GO:0006275 105 56 3,000 4,794E-05 3,253E-03 ! aging GO:0007568 112 58 3,000 5,507E-05 3,636E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 2,000 6,376E-05 4,099E-03 ! cell aging GO:0007569 48 22 2,000 6,376E-05 3,994E-03 ! positive regulation of DNA replication GO:0045740 44 23 2,000 7,313E-05 4,467E-03 ! response to molecule of bacterial origin GO:0002237 40 23 2,000 7,313E-05 4,358E-03 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 9,153E-05 5,324E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 9,449E-05 5,368E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 2,000 9,449E-05 5,246E-03 ! interaction with host GO:0051701 66 25 2,000 9,449E-05 5,13E-03 ! protein tetramerization GO:0051262 57 25 2,000 9,449E-05 5,018E-03 ! myeloid cell differentiation GO:0030099 126 67 3,000 9,707E-05 5,046E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 1,065E-04 5,422E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 1,195E-04 5,96E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 1,238E-04 6,049E-03 ! protein maturation by protein folding GO:0022417 14 5 1,000 1,238E-04 5,93E-03 ! apoptotic cell clearance GO:0043277 23 5 1,000 1,238E-04 5,816E-03 ! lipoprotein particle clearance GO:0034381 10 5 1,000 1,238E-04 5,707E-03 ! response to protozoan GO:0001562 13 5 1,000 1,238E-04 5,601E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 1,238E-04 5,499E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 1,238E-04 5,401E-03 ! muscle cell migration GO:0014812 8 5 1,000 1,238E-04 5,306E-03 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 1,000 1,238E-04 5,215E-03 ! lipoprotein catabolic process GO:0042159 11 5 1,000 1,238E-04 5,126E-03 ! lipid glycosylation GO:0030259 7 5 1,000 1,238E-04 5,041E-03 ! T cell activation during immune response GO:0002286 9 5 1,000 1,238E-04 4,958E-03 ! sequestering of calcium ion GO:0051208 7 5 1,000 1,238E-04 4,878E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 1,335E-04 5,178E-03 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 1,486E-04 5,671E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 1,646E-04 6,188E-03 ! iron ion homeostasis GO:0055072 60 31 2,000 1,818E-04 6,73E-03 ! response to UV-C GO:0010225 14 6 1,000 1,853E-04 6,755E-03 ! response to exogenous dsRNA GO:0043330 13 6 1,000 1,853E-04 6,656E-03 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 1,000 1,853E-04 6,56E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 1,853E-04 6,466E-03 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 1,000 1,853E-04 6,375E-03 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 2,001E-04 6,79E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 2,402E-04 8,038E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 2,588E-04 8,543E-03 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 1,000 2,588E-04 8,429E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 2,588E-04 8,318E-03 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 1,000 2,588E-04 8,21E-03 GO:0031958|corticosteroid receptor signaling pathway, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 2,588E-04 8,105E-03 ! regulation of granule cell precursor proliferation GO:0021936 12 7 1,000 2,588E-04 8,002E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 1,000 2,588E-04 7,902E-03 ! maintenance of protein location in nucleus GO:0051457 19 7 1,000 2,588E-04 7,805E-03 ! male sex determination GO:0030238 15 7 1,000 2,588E-04 7,71E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 2,588E-04 7,617E-03 ! fibrinolysis GO:0042730 11 7 1,000 2,588E-04 7,526E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 2,588E-04 7,438E-03 ! regulation of interleukin-10 production GO:0032653 13 7 1,000 2,588E-04 7,351E-03 ! regulation of meiosis GO:0040020 12 7 1,000 2,588E-04 7,267E-03 GO:0051445|regulation of meiotic cell cycle, ! T cell lineage commitment GO:0002360 16 7 1,000 2,588E-04 7,184E-03 ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 1,000 2,588E-04 7,103E-03 ! lymphocyte activation during immune response GO:0002285 11 7 1,000 2,588E-04 7,024E-03 ! mitochondrion organization GO:0007005 159 87 3,000 2,669E-04 7,166E-03 ! regulation of protein transport GO:0051223 165 87 3,000 2,669E-04 7,088E-03 GO:0070201|regulation of establishment of protein localization, ! maintenance of protein location in cell GO:0032507 89 37 2,000 3,094E-04 8,129E-03 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 3,351E-04 8,709E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 3,442E-04 8,852E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 3,442E-04 8,76E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 3,442E-04 8,67E-03 ! ER overload response GO:0006983 13 8 1,000 3,442E-04 8,581E-03 ! positive regulation of interferon-gamma production GO:0032729 12 8 1,000 3,442E-04 8,495E-03 ! response to tumor cell GO:0002347 16 8 1,000 3,442E-04 8,41E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 3,442E-04 8,326E-03 ! regulation of protein localization GO:0032880 188 97 3,000 4,043E-04 9,683E-03 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 4,202E-04 9,966E-03 ! maintenance of protein location GO:0045185 95 41 2,000 4,202E-04 9,87E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 4,416E-04 0,01027362 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 1,000 4,416E-04 0,0101767 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 20 9 1,000 4,416E-04 0,01008159 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 1,000 4,416E-04 9,988E-03 ! middle ear morphogenesis GO:0042474 14 9 1,000 4,416E-04 9,897E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 1,000 4,416E-04 9,807E-03 ! regulation of Notch signaling pathway GO:0008593 24 9 1,000 4,416E-04 9,718E-03 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 4,416E-04 9,632E-03 ! regulation of telomere maintenance GO:0032204 17 9 1,000 4,416E-04 9,546E-03 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 4,513E-04 9,672E-03 ! T cell differentiation GO:0030217 93 42 2,000 4,513E-04 9,588E-03 ! positive regulation of transcription factor activity GO:0051091 71 43 2,000 4,839E-04 0,01019158 GO:0090047|positive regulation of transcription regulator activity, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 1,000 5,507E-04 0,01149814 ! regulation of developmental growth GO:0048638 16 10 1,000 5,507E-04 0,0114007 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 1,000 5,507E-04 0,01130489 ! polyamine biosynthetic process GO:0006596 13 10 1,000 5,507E-04 0,01121069 ! intestinal cholesterol absorption GO:0030299 19 10 1,000 5,507E-04 0,01111804 ! protein heterooligomerization GO:0051291 17 10 1,000 5,507E-04 0,0110269 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 5,507E-04 0,01093726 ! positive regulation of phagocytosis GO:0050766 14 10 1,000 5,507E-04 0,01084905 ! response to dsRNA GO:0043331 23 10 1,000 5,507E-04 0,01076226 ! leukocyte activation during immune response GO:0002366 15 10 1,000 5,507E-04 0,01067684 GO:0002263|cell activation during immune response, ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 5,507E-04 0,01059277 GO:0043470|regulation of carbohydrate catabolic process, ! B cell differentiation GO:0030183 124 45 2,000 5,536E-04 0,01056521 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 5,907E-04 0,01118578 ! positive regulation of cell cycle GO:0045787 96 48 2,000 6,695E-04 0,01258185 ! cellular component disassembly GO:0022411 89 48 2,000 6,695E-04 0,0124858 ! cortical actin cytoskeleton organization GO:0030866 29 11 1,000 6,715E-04 0,01242741 ! detection of mechanical stimulus GO:0050982 22 11 1,000 6,715E-04 0,01233397 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 6,715E-04 0,01224193 ! regulation of intracellular pH GO:0051453 21 11 1,000 6,715E-04 0,01215124 ! alpha-beta T cell activation GO:0046631 26 11 1,000 6,715E-04 0,0120619 ! regulation of embryonic development GO:0045995 35 11 1,000 6,715E-04 0,01197385 ! activation of caspase activity GO:0006919 95 50 2,000 7,548E-04 0,01336218 ! regulation of cell projection organization GO:0031344 135 51 2,000 7,999E-04 0,01405886 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 8,039E-04 0,0140281 ! cortical cytoskeleton organization GO:0030865 30 12 1,000 8,039E-04 0,01392861 ! virus-host interaction GO:0019048 30 12 1,000 8,039E-04 0,01383052 ! polyamine metabolic process GO:0006595 18 12 1,000 8,039E-04 0,01373381 ! focal adhesion formation GO:0048041 37 12 1,000 8,039E-04 0,01363843 ! lipid digestion GO:0044241 21 12 1,000 8,039E-04 0,01354437 ! entry into host cell GO:0030260 34 12 1,000 8,039E-04 0,0134516 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! regulation of phagocytosis GO:0050764 17 12 1,000 8,039E-04 0,0133601 ! regulation of interleukin-8 production GO:0032677 22 12 1,000 8,039E-04 0,01326983 ! histone acetylation GO:0016573 27 12 1,000 8,039E-04 0,01318077 ! peptidyl-lysine modification GO:0018205 21 12 1,000 8,039E-04 0,0130929 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 2,000 8,952E-04 0,01448306 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 9,479E-04 0,0152344 ! response to X-ray GO:0010165 28 13 1,000 9,479E-04 0,01513483 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 9,479E-04 0,01503655 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 9,479E-04 0,01493954 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! spleen development GO:0048536 24 13 1,000 9,479E-04 0,01484378 ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 9,479E-04 0,01474923 ! response to UV GO:0009411 120 55 2,000 9,974E-04 0,01542139 ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 1,103E-03 0,01695159 ! regulation of cellular pH GO:0030641 27 14 1,000 1,103E-03 0,01684564 ! response to gamma radiation GO:0010332 30 14 1,000 1,103E-03 0,01674101 ! positive regulation of caspase activity GO:0043280 108 57 2,000 1,107E-03 0,01668859 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 108 57 2,000 1,107E-03 0,0165862 ! positive regulation of cell migration GO:0030335 137 58 2,000 1,164E-03 0,01733951 ! establishment of organelle localization GO:0051656 122 59 2,000 1,223E-03 0,01811096 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 1,27E-03 0,0186913 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 1,000 1,27E-03 0,01857937 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 1,27E-03 0,01846878 ! G1/S transition checkpoint GO:0031575 37 15 1,000 1,27E-03 0,0183595 ! intestinal absorption GO:0050892 31 15 1,000 1,27E-03 0,0182515 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 1,27E-03 0,01814477 ! lipid modification GO:0030258 112 60 2,000 1,284E-03 0,01824124 ! viral reproductive process GO:0022415 132 62 2,000 1,412E-03 0,01994072 ! DNA damage response, signal transduction GO:0042770 136 62 2,000 1,412E-03 0,01982612 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 1,448E-03 0,02021593 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 1,448E-03 0,02010106 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 1,000 1,448E-03 0,0199875 ! intermediate filament-based process GO:0045103 36 16 1,000 1,448E-03 0,01987521 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 1,000 1,448E-03 0,01976417 ! DNA replication initiation GO:0006270 28 16 1,000 1,448E-03 0,01965437 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 1,448E-03 0,01954579 ! regulation of protein complex assembly GO:0043254 132 63 2,000 1,479E-03 0,01985119 ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 1,548E-03 0,0206604 ! positive regulation of cell motion GO:0051272 157 65 2,000 1,618E-03 0,02148699 ! activation of MAPKK activity GO:0000186 43 17 1,000 1,637E-03 0,02162271 ! regulation of survival gene product expression GO:0045884 38 17 1,000 1,637E-03 0,02150646 ! regulation of striated muscle contraction GO:0006942 23 17 1,000 1,637E-03 0,02139145 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 1,637E-03 0,02127767 ! negative regulation of blood coagulation GO:0030195 25 17 1,000 1,637E-03 0,02116509 ! negative regulation of cell growth GO:0030308 142 67 2,000 1,766E-03 0,022704 ! activation of MAPK activity GO:0000187 124 67 2,000 1,766E-03 0,02258513 ! cell-substrate junction assembly GO:0007044 56 18 1,000 1,838E-03 0,02338439 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 1,838E-03 0,02326323 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 1,838E-03 0,02314331 ! viral reproduction GO:0016032 142 68 2,000 1,843E-03 0,02308338 ! cell projection assembly GO:0030031 138 68 2,000 1,843E-03 0,02296561 ! negative regulation of cell size GO:0045792 144 69 2,000 1,921E-03 0,02382625 ! negative regulation of kinase activity GO:0033673 145 70 2,000 2,002E-03 0,02470374 ! positive regulation of translation GO:0045727 31 19 1,000 2,049E-03 0,02515776 ! inositol metabolic process GO:0006020 33 19 1,000 2,049E-03 0,02503197 ! cellular response to hydrogen peroxide GO:0070301 25 19 1,000 2,049E-03 0,02490743 GO:0042744|hydrogen peroxide catabolic process, ! protein export from nucleus GO:0006611 40 19 1,000 2,049E-03 0,02478413 ! B cell activation GO:0042113 179 72 2,000 2,17E-03 0,02611746 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 2,272E-03 0,02720481 ! protein amino acid acetylation GO:0006473 41 20 1,000 2,272E-03 0,02707211 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 2,272E-03 0,02694069 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 38 20 1,000 2,272E-03 0,02681054 ! actin filament bundle formation GO:0051017 47 20 1,000 2,272E-03 0,02668164 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 1,000 2,272E-03 0,02655398 ! negative regulation of translation GO:0017148 32 20 1,000 2,272E-03 0,02642753 ! negative regulation of coagulation GO:0050819 30 20 1,000 2,272E-03 0,02630228 ! regulation of caspase activity GO:0043281 136 74 2,000 2,347E-03 0,02704309 ! negative regulation of transferase activity GO:0051348 155 74 2,000 2,347E-03 0,02691612 ! organelle localization GO:0051640 155 74 2,000 2,347E-03 0,02679035 ! regulation of transcription factor activity GO:0051090 137 75 2,000 2,438E-03 0,02770551 GO:0090046|regulation of transcription regulator activity, ! lipid phosphorylation GO:0046834 43 21 1,000 2,505E-03 0,02833228 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 2,505E-03 0,02820172 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 2,505E-03 0,02807235 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 2,505E-03 0,02794417 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 2,505E-03 0,02781715 ! cell-matrix adhesion GO:0007160 181 76 2,000 2,532E-03 0,02798897 ! lymphocyte differentiation GO:0030098 193 76 2,000 2,532E-03 0,0278629 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 2,628E-03 0,0287884 ! cellular response to starvation GO:0009267 37 22 1,000 2,749E-03 0,02998292 ! apoptotic nuclear changes GO:0030262 34 22 1,000 2,749E-03 0,02984966 ! sarcomere organization GO:0045214 32 22 1,000 2,749E-03 0,02971758 ! protein stabilization GO:0050821 41 22 1,000 2,749E-03 0,02958667 ! protein oligomerization GO:0051259 149 79 2,000 2,826E-03 0,03028329 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 3,004E-03 0,03204713 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 3,004E-03 0,0319078 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 3,004E-03 0,03176967 ! response to hypoxia GO:0001666 178 81 2,000 3,034E-03 0,03194546 ! regulation of peptidase activity GO:0052547 150 82 2,000 3,141E-03 0,03293161 ! cell-substrate adhesion GO:0031589 189 82 2,000 3,141E-03 0,03279087 ! response to oxygen levels GO:0070482 183 83 2,000 3,25E-03 0,03378892 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 3,27E-03 0,03384509 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 3,27E-03 0,03370228 ! protein amino acid O-linked glycosylation GO:0006493 45 24 1,000 3,27E-03 0,03356068 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 3,27E-03 0,03342026 ! sex determination GO:0007530 48 24 1,000 3,27E-03 0,03328101 ! regulation of tumor necrosis factor production GO:0032680 37 24 1,000 3,27E-03 0,03314291 ! T cell activation GO:0042110 189 84 2,000 3,362E-03 0,03393957 ! negative regulation of transport GO:0051051 164 85 2,000 3,476E-03 0,03494669 ! negative regulation of growth GO:0045926 168 85 2,000 3,476E-03 0,03480347 ! keratinization GO:0031424 37 25 1,000 3,546E-03 0,03535481 ! negative regulation of DNA replication GO:0008156 45 25 1,000 3,546E-03 0,03521109 ! initiation of viral infection GO:0019059 60 26 1,000 3,832E-03 0,03790311 ! macromolecular complex disassembly GO:0032984 54 26 1,000 3,832E-03 0,03775027 ! digestive system process GO:0022600 49 26 1,000 3,832E-03 0,03759866 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 3,832E-03 0,03744827 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 3,832E-03 0,03729907 ! negative regulation of cell development GO:0010721 83 26 1,000 3,832E-03 0,03715106 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 1,000 3,832E-03 0,03700422 ! regulation of blood coagulation GO:0030193 46 26 1,000 3,832E-03 0,03685853 ! positive regulation of nuclear division GO:0051785 41 26 1,000 3,832E-03 0,03671399 GO:0045840|positive regulation of mitosis, ! regulation of cell cycle process GO:0010564 161 90 2,000 4,082E-03 0,03895307 ! regulation of interferon-gamma production GO:0032649 43 27 1,000 4,129E-03 0,03925163 ! mitochondrial membrane organization GO:0007006 60 27 1,000 4,129E-03 0,03909949 ! response to starvation GO:0042594 47 27 1,000 4,129E-03 0,03894853 ! cellular response to oxidative stress GO:0034599 43 27 1,000 4,129E-03 0,03879873 ! regulation of chromosome organization GO:0033044 49 27 1,000 4,129E-03 0,03865007 ! cellular response to nutrient levels GO:0031669 45 27 1,000 4,129E-03 0,03850256 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 4,437E-03 0,04121121 ! protein amino acid acylation GO:0043543 59 28 1,000 4,437E-03 0,04105511 ! base-excision repair GO:0006284 41 28 1,000 4,437E-03 0,04090018 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 4,437E-03 0,04074642 ! positive regulation of MAP kinase activity GO:0043406 174 93 2,000 4,474E-03 0,04093812 ! regulation of membrane potential GO:0042391 179 94 2,000 4,61E-03 0,04202212 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 4,754E-03 0,04317665 ! somitogenesis GO:0001756 52 29 1,000 4,754E-03 0,04301674 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 4,754E-03 0,042858 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 1,000 5,082E-03 0,04564484 ! myofibril assembly GO:0030239 50 30 1,000 5,082E-03 0,04547764 GO:0055002|striated muscle cell development, ! regulation of coagulation GO:0050818 52 30 1,000 5,082E-03 0,04531167 ! cell junction assembly GO:0034329 85 31 1,000 5,42E-03 0,04814909 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 5,42E-03 0,04797463 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 1,000 5,768E-03 0,05087055 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 1,000 5,768E-03 0,05068756 ! response to mechanical stimulus GO:0009612 60 32 1,000 5,768E-03 0,05050588 ! muscle cell development GO:0055001 52 32 1,000 5,768E-03 0,0503255 ! positive regulation of catabolic process GO:0009896 72 32 1,000 5,768E-03 0,05014641 ! regulation of pH GO:0006885 56 33 1,000 6,126E-03 0,05306966 ! cholesterol homeostasis GO:0042632 60 33 1,000 6,126E-03 0,05288213 GO:0055092|sterol homeostasis, ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 6,126E-03 0,05269593 ! response to ionizing radiation GO:0010212 74 33 1,000 6,126E-03 0,05251103 ! negative regulation of protein transport GO:0051224 74 33 1,000 6,126E-03 0,05232742 ! response to hydrogen peroxide GO:0042542 56 34 1,000 6,494E-03 0,05527639 ! cholesterol transport GO:0030301 62 34 1,000 6,494E-03 0,05508446 ! DNA damage checkpoint GO:0000077 78 35 1,000 6,871E-03 0,05808653 ! negative regulation of secretion GO:0051048 68 35 1,000 6,871E-03 0,05788623 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 6,871E-03 0,05768731 ! positive regulation of endocytosis GO:0045807 56 35 1,000 6,871E-03 0,05748975 ! sterol transport GO:0015918 63 35 1,000 6,871E-03 0,05729354 ! biogenic amine biosynthetic process GO:0042401 65 35 1,000 6,871E-03 0,05709866 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 1,000 7,259E-03 0,06011359 ! negative regulation of DNA binding GO:0043392 67 36 1,000 7,259E-03 0,0599105 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 7,259E-03 0,05970878 ! actomyosin structure organization GO:0031032 68 37 1,000 7,656E-03 0,06276394 ! cell junction organization GO:0034330 96 37 1,000 7,656E-03 0,06255402 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 1,000 8,063E-03 0,06565755 ! DNA integrity checkpoint GO:0031570 82 38 1,000 8,063E-03 0,06543942 ! regulation of protein stability GO:0031647 77 38 1,000 8,063E-03 0,06522273 ! negative regulation of binding GO:0051100 71 39 1,000 8,479E-03 0,06836359 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 8,479E-03 0,06813871 ! carbohydrate homeostasis GO:0033500 59 39 1,000 8,479E-03 0,0679153 GO:0042593|glucose homeostasis, ! mammary gland development GO:0030879 93 40 1,000 8,905E-03 0,0710921 ! nucleus organization GO:0006997 73 40 1,000 8,905E-03 0,07086053 ! lipid homeostasis GO:0055088 75 40 1,000 8,905E-03 0,07063047 ! mesenchymal cell development GO:0014031 94 41 1,000 9,34E-03 0,07384189 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 9,34E-03 0,07360369 ! ear morphogenesis GO:0042471 64 42 1,000 9,784E-03 0,07685811 ! regulation of protein secretion GO:0050708 77 42 1,000 9,784E-03 0,07661177 ! glucose transport GO:0015758 66 43 1,000 0,0102379 0,07990797 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,0102379 0,07965349 ! segmentation GO:0035282 78 43 1,000 0,0102379 0,07940062 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,0102379 0,07914935 ! response to reactive oxygen species GO:0000302 75 44 1,000 0,01070076 0,0824667 ! hexose transport GO:0008645 68 44 1,000 0,01070076 0,08220737 GO:0015749|monosaccharide transport, ! phagocytosis GO:0006909 105 44 1,000 0,01070076 0,08194967 ! double-strand break repair GO:0006302 85 44 1,000 0,01070076 0,08169358 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 0,01117272 0,08503099 ! keratinocyte differentiation GO:0030216 81 45 1,000 0,01117272 0,08476692 ! polyol metabolic process GO:0019751 77 45 1,000 0,01117272 0,08450449 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 1,000 0,01165372 0,08787049 ! pigmentation GO:0043473 103 46 1,000 0,01165372 0,08760012 ! mitochondrial transport GO:0006839 94 48 1,000 0,01264257 0,09474173 ! response to calcium ion GO:0051592 94 49 1,000 0,01315028 0,09824509 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,01315028 0,09794556 ! regulation of action potential GO:0001508 102 50 1,000 0,01366676 0,10148298 ! immunoglobulin mediated immune response GO:0016064 89 50 1,000 0,01366676 0,10117545 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,01366676 0,10086979 ! epidermal cell differentiation GO:0009913 87 50 1,000 0,01366676 0,10056596 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,01366676 0,10026396 ! viral infectious cycle GO:0019058 104 51 1,000 0,01419194 0,10380512 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,01419194 0,10349525 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,01472575 0,10706847 ! histone modification GO:0016570 104 52 1,000 0,01472575 0,10675076 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,01472575 0,10643493 ! positive regulation of growth GO:0045927 96 53 1,000 0,01526812 0,11002958 ! chromatin remodeling GO:0006338 122 53 1,000 0,01526812 0,10970596 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,01526812 0,10938425 ! regulation of muscle contraction GO:0006937 94 54 1,000 0,015819 0,11299945 ! covalent chromatin modification GO:0016569 115 54 1,000 0,015819 0,11267001 ! heart morphogenesis GO:0003007 105 57 1,000 0,01752195 0,12443644 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,01752195 0,12407575 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01760028 0,12427015 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01760028 0,12391202 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01760028 0,12355595 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01760028 0,12320193 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01760028 0,12284992 ! neuron fate determination GO:0048664 7 5 0,000 0,01760028 0,12249992 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01760028 0,12215191 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01760028 0,12180587 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01760028 0,12146179 ! polyol transport GO:0015791 12 5 0,000 0,01760028 0,12111964 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01760028 0,12077942 ! response to superoxide GO:0000303 10 5 0,000 0,01760028 0,1204411 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01760028 0,12010467 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01760028 0,11977012 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01760028 0,11943742 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01760028 0,11910657 ! female meiosis GO:0007143 10 5 0,000 0,01760028 0,11877755 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01760028 0,11845034 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01760028 0,11812492 ! hypothalamus development GO:0021854 9 5 0,000 0,01760028 0,11780129 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01760028 0,11747943 ! cobalt ion transport GO:0006824 11 5 0,000 0,01760028 0,11715932 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01760028 0,11684096 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01760028 0,11652432 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01760028 0,11620938 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01760028 0,11589615 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01760028 0,1155846 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01760028 0,11527472 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01760028 0,1149665 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01760028 0,11465993 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01760028 0,11435498 ! transposition GO:0032196 9 5 0,000 0,01760028 0,11405165 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01760028 0,11374993 ! negative chemotaxis GO:0050919 16 5 0,000 0,01760028 0,11344979 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01760028 0,11315124 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01760028 0,11285426 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01760028 0,11255883 ! behavioral response to pain GO:0048266 10 5 0,000 0,01760028 0,11226494 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01760028 0,11197258 ! Notch receptor processing GO:0007220 11 5 0,000 0,01760028 0,11168175 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01760028 0,11139242 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01760028 0,11110458 ! micturition GO:0060073 9 5 0,000 0,01760028 0,11081823 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01760028 0,11053335 ! copulation GO:0007620 9 5 0,000 0,01760028 0,11024993 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01760028 0,10996796 ! bioluminescence GO:0008218 9 5 0,000 0,01760028 0,10968743 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01760028 0,10940833 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01760028 0,10913064 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01760028 0,10885436 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01760028 0,10857948 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01760028 0,10830598 ! grooming behavior GO:0007625 6 5 0,000 0,01760028 0,10803385 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01760028 0,10776309 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01760028 0,10749368 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01760028 0,10722562 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01760028 0,10695889 ! lymph vessel development GO:0001945 10 5 0,000 0,01760028 0,10669348 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01760028 0,10642939 ! endochondral ossification GO:0001958 17 5 0,000 0,01760028 0,1061666 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01760028 0,1059051 ! single strand break repair GO:0000012 8 5 0,000 0,01760028 0,10564489 ! parathyroid gland development GO:0060017 14 5 0,000 0,01760028 0,10538596 ! anagen GO:0042640 7 5 0,000 0,01760028 0,10512829 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01760028 0,10487188 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01760028 0,10461672 ! cytokine secretion GO:0050663 15 5 0,000 0,01760028 0,1043628 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01760028 0,1041101 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01760028 0,10385863 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01760028 0,10360837 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01760028 0,10335931 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01760028 0,10311144 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01760028 0,10286477 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01760028 0,10261927 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01760028 0,10237493 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01760028 0,10213176 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01760028 0,10188974 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01760028 0,10164887 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01760028 0,10140913 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01760028 0,10117052 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01760028 0,10093303 ! microvillus organization GO:0032528 8 5 0,000 0,01760028 0,10069666 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01760028 0,10046138 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01760028 0,10022721 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01760028 0,09999412 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01760028 0,09976212 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01760028 0,09953119 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01760028 0,09930132 ! polyol catabolic process GO:0046174 9 5 0,000 0,01760028 0,09907252 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01760028 0,09884476 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01760028 0,09861806 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01760028 0,09839239 ! mitochondrial fission GO:0000266 8 5 0,000 0,01760028 0,09816774 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01760028 0,09794413 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01760028 0,09772153 ! mRNA transcription GO:0009299 10 5 0,000 0,01760028 0,09749994 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01760028 0,09727935 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01760028 0,09705976 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01760028 0,09684115 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01760028 0,09662353 ! monocyte activation GO:0042117 10 5 0,000 0,01760028 0,09640689 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01760028 0,09619121 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01760028 0,0959765 ! response to food GO:0032094 6 5 0,000 0,01760028 0,09576274 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01760028 0,09554994 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01760028 0,09533808 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01760028 0,09512715 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01760028 0,09491716 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,01760028 0,09470809 ! forebrain neuron development GO:0021884 13 5 0,000 0,01760028 0,09449994 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01760028 0,0942927 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01760028 0,09408637 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01760028 0,09388094 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01760028 0,09367641 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01760028 0,09347277 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01760028 0,09327 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01760028 0,09306812 ! nucleobase transport GO:0015851 6 5 0,000 0,01760028 0,09286711 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01760028 0,09266697 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01760028 0,09246768 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01760028 0,09226925 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01760028 0,09207168 ! basic amino acid transport GO:0015802 12 5 0,000 0,01760028 0,09187494 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01760028 0,09167905 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01760028 0,09148398 ! actin nucleation GO:0045010 11 5 0,000 0,01760028 0,09128975 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01760028 0,09109634 ! depurination GO:0045007 5 5 0,000 0,01760028 0,09090375 ! depyrimidination GO:0045008 10 5 0,000 0,01760028 0,09071197 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01760028 0,09052099 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01760028 0,09033082 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01760028 0,09014145 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01760028 0,08995287 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01760028 0,08976508 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01760028 0,08957807 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01760028 0,08939183 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01760028 0,08920637 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01760028 0,08902168 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01760028 0,08883775 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01760028 0,08865458 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01760028 0,08847217 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01760028 0,0882905 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01760028 0,08810957 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01760028 0,08792939 ! response to arsenic GO:0046685 11 5 0,000 0,01760028 0,08774994 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01760028 0,08757123 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01760028 0,08739324 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01760028 0,08721597 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01760028 0,08703942 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01760028 0,08686358 ! response to mercury ion GO:0046689 8 5 0,000 0,01760028 0,08668845 ! response to cadmium ion GO:0046686 7 5 0,000 0,01760028 0,08651403 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01760028 0,08634031 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01760028 0,08616728 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01760028 0,08599494 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01760028 0,0858233 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01760028 0,08565234 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01760028 0,08548205 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01760028 0,08531244 ! decidualization GO:0046697 11 5 0,000 0,01760028 0,08514351 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01760028 0,08497524 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01760028 0,08480764 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01760028 0,08464069 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01760028 0,08447441 ! embryonic cleavage GO:0040016 6 5 0,000 0,01760028 0,08430877 ! peroxisome fission GO:0016559 5 5 0,000 0,01760028 0,08414378 ! histone demethylation GO:0016577 13 5 0,000 0,01760028 0,08397944 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01760028 0,08381574 ! mitotic recombination GO:0006312 9 5 0,000 0,01760028 0,08365267 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01760028 0,08349024 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01760028 0,08332843 ! metaphase plate congression GO:0051310 7 5 0,000 0,01760028 0,08316726 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01760028 0,0830067 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01760028 0,08284677 ! enteric nervous system development GO:0048484 8 5 0,000 0,01760028 0,08268745 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01760028 0,08252874 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01760028 0,08237064 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01760028 0,08221314 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01760028 0,08205624 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01760028 0,08189995 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01760028 0,08174424 ! B cell homeostasis GO:0001782 13 5 0,000 0,01760028 0,08158913 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01760028 0,08143461 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01760028 0,08128067 ! metaphase GO:0051323 11 5 0,000 0,01760028 0,08112731 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01760028 0,08097452 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01760028 0,08082232 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01760028 0,08067068 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01760028 0,08051961 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01760028 0,08036911 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01760028 0,08021916 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01760028 0,08006978 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01760028 0,07992095 ! response to redox state GO:0051775 6 5 0,000 0,01760028 0,07977268 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01760028 0,07962495 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01760028 0,07947777 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01760028 0,07933113 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01760028 0,07918503 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01760028 0,07903947 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01760028 0,07889444 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01760028 0,07874995 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01760028 0,07860598 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01760028 0,07846254 ! striatum development GO:0021756 14 5 0,000 0,01760028 0,07831962 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01760028 0,07817722 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01760028 0,07803534 ! glial cell migration GO:0008347 10 5 0,000 0,01760028 0,07789397 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01760028 0,07775311 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01760028 0,07761277 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01760028 0,07747292 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01760028 0,07733358 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01760028 0,07719474 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01760028 0,0770564 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01760028 0,07691856 ! neuroprotection GO:0043526 8 5 0,000 0,01760028 0,0767812 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01760028 0,07664434 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01760028 0,07650796 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01760028 0,07637206 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01760028 0,07623665 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01760028 0,07610172 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01760028 0,07596727 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01760028 0,07583328 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01760028 0,07569978 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01760028 0,07556674 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,01760028 0,07543416 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01760028 0,07530205 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01760028 0,07517041 ! spindle assembly GO:0051225 6 5 0,000 0,01760028 0,07503922 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01760028 0,07490849 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01760028 0,07477821 ! protein palmitoylation GO:0018345 12 5 0,000 0,01760028 0,07464839 ! drug metabolic process GO:0017144 7 5 0,000 0,01760028 0,07451902 ! stem cell division GO:0017145 11 5 0,000 0,01760028 0,07439009 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01760028 0,07426161 ! organ regeneration GO:0031100 7 5 0,000 0,01760028 0,07413357 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01760028 0,07400598 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01760028 0,07387882 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,01810617 0,07587198 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 1,000 0,01810617 0,07574206 ! nuclear export GO:0051168 110 59 1,000 0,01869855 0,07808643 ! DNA catabolic process GO:0006308 94 60 1,000 0,01929904 0,08045659 ! regulation of endocytosis GO:0030100 104 60 1,000 0,01929904 0,08031953 ! kidney development GO:0001822 133 60 1,000 0,01929904 0,08018293 ! regulation of heart contraction GO:0008016 123 61 1,000 0,01990758 0,08257082 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,0205241 0,08498367 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02108328 0,08715134 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02108328 0,08700413 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02108328 0,08685741 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02108328 0,08671118 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02108328 0,08656545 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02108328 0,08642021 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02108328 0,08627545 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02108328 0,08613118 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02108328 0,08598738 ! response to oxygen radical GO:0000305 11 6 0,000 0,02108328 0,08584407 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02108328 0,08570124 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02108328 0,08555888 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02108328 0,08541699 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02108328 0,08527557 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02108328 0,08513462 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02108328 0,08499413 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02108328 0,08485411 ! forebrain regionalization GO:0021871 9 6 0,000 0,02108328 0,08471454 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02108328 0,08457544 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02108328 0,08443679 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02108328 0,0842986 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02108328 0,08416085 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02108328 0,08402356 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02108328 0,08388672 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02108328 0,08375031 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02108328 0,08361436 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02108328 0,08347884 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02108328 0,08334376 ! malate metabolic process GO:0006108 13 6 0,000 0,02108328 0,08320912 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02108328 0,08307491 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02108328 0,08294113 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02108328 0,08280779 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02108328 0,08267487 ! protein refolding GO:0042026 15 6 0,000 0,02108328 0,08254238 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02108328 0,08241031 ! opsonization GO:0008228 8 6 0,000 0,02108328 0,08227866 ! mating behavior GO:0007617 7 6 0,000 0,02108328 0,08214744 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02108328 0,08201663 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02108328 0,08188624 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02108328 0,08175626 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02108328 0,08162669 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02108328 0,08149754 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02108328 0,08136879 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02108328 0,08124045 ! toxin metabolic process GO:0009404 11 6 0,000 0,02108328 0,08111251 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02108328 0,08098497 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02108328 0,08085784 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02108328 0,0807311 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02108328 0,08060476 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02108328 0,08047882 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02108328 0,08035327 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02108328 0,0802281 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02108328 0,08010333 ! thymic T cell selection GO:0045061 16 6 0,000 0,02108328 0,07997895 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02108328 0,07985495 ! protein lipoylation GO:0009249 10 6 0,000 0,02108328 0,07973134 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02108328 0,0796081 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02108328 0,07948525 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02108328 0,07936278 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02108328 0,07924068 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02108328 0,07911896 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02108328 0,07899761 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02108328 0,07887664 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02108328 0,07875603 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02108328 0,07863579 ! hyperosmotic response GO:0006972 10 6 0,000 0,02108328 0,07851592 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02108328 0,07839641 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02108328 0,07827727 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02108328 0,07815849 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02108328 0,07804007 ! urea metabolic process GO:0019627 7 6 0,000 0,02108328 0,077922 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02108328 0,07780429 ! neutrophil activation GO:0042119 7 6 0,000 0,02108328 0,07768694 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02108328 0,07756994 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02108328 0,0774533 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02108328 0,077337 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02108328 0,07722105 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02108328 0,07710545 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02108328 0,0769902 ! neuron apoptosis GO:0051402 15 6 0,000 0,02108328 0,07687529 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02108328 0,07676072 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02108328 0,07664649 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02108328 0,07653261 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02108328 0,07641906 ! carnitine transport GO:0015879 10 6 0,000 0,02108328 0,07630584 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02108328 0,07619296 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02108328 0,07608042 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02108328 0,07596821 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02108328 0,07585632 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02108328 0,07574477 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02108328 0,07563354 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02108328 0,07552264 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02108328 0,07541207 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02108328 0,07530182 ! establishment of spindle localization GO:0051293 16 6 0,000 0,02108328 0,07519189 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02108328 0,07508228 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02108328 0,07497299 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,02108328 0,07486402 ! astrocyte development GO:0014002 16 6 0,000 0,02108328 0,07475536 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02108328 0,07464702 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02108328 0,07453899 ! interaction with symbiont GO:0051702 14 6 0,000 0,02108328 0,07443128 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02108328 0,07432387 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02108328 0,07421678 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02108328 0,07410999 ! response to copper ion GO:0046688 10 6 0,000 0,02108328 0,07400351 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02108328 0,07389734 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02108328 0,07379147 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02108328 0,0736859 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02108328 0,07358063 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02108328 0,07347567 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02108328 0,073371 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02108328 0,07326663 ! hair follicle maturation GO:0048820 8 6 0,000 0,02108328 0,07316256 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02108328 0,07305878 ! Schwann cell development GO:0014044 15 6 0,000 0,02108328 0,0729553 ! response to pheromone GO:0019236 6 6 0,000 0,02108328 0,07285211 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02108328 0,07274921 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02108328 0,07264661 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02108328 0,07254429 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02108328 0,07244225 ! subpallium development GO:0021544 15 6 0,000 0,02108328 0,07234051 ! neural tube patterning GO:0021532 8 6 0,000 0,02108328 0,07223905 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02108328 0,07213788 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02108328 0,07203698 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02108328 0,07193637 ! G2 phase GO:0051319 16 6 0,000 0,02108328 0,07183604 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02108328 0,07173599 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02108328 0,07163622 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02108328 0,07153673 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02108328 0,07143751 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02108328 0,07133856 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02108328 0,07123989 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02108328 0,0711415 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02108328 0,07104337 ! receptor internalization GO:0031623 11 6 0,000 0,02108328 0,07094551 ! plasminogen activation GO:0031639 9 6 0,000 0,02108328 0,07084793 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02108328 0,07075061 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02108328 0,07065356 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02108328 0,07055677 ! protein deubiquitination GO:0016579 16 6 0,000 0,02108328 0,07046025 ! protein destabilization GO:0031648 9 6 0,000 0,02108328 0,07036399 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02108328 0,070268 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02108328 0,07017227 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02108328 0,07007679 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02108328 0,06998158 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02108328 0,06988663 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02108328 0,06979193 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02108328 0,06969749 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02108328 0,0696033 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02108328 0,06950937 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02108328 0,06941569 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02108328 0,06932227 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02108328 0,06922909 ! neural plate development GO:0001840 9 6 0,000 0,02108328 0,06913617 ! catecholamine transport GO:0051937 9 6 0,000 0,02108328 0,06904349 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02108328 0,06895106 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02108328 0,06885888 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02108328 0,06876695 ! maternal placenta development GO:0001893 12 6 0,000 0,02108328 0,06867526 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02108328 0,06858381 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02108328 0,06849261 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02108328 0,06840165 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02108328 0,06831093 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02108328 0,06822045 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02108328 0,06813022 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02108328 0,06804022 GO:0055081|anion homeostasis, ! regulation of mitosis GO:0007088 112 63 1,000 0,02114853 0,06816076 GO:0051783|regulation of nuclear division, ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,02114853 0,06807095 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,02178082 0,07001386 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,02242089 0,07197667 ! lymphocyte mediated immunity GO:0002449 122 65 1,000 0,02242089 0,07188221 ! ear development GO:0043583 114 66 1,000 0,0230687 0,07386217 ! regulation of cytokine biosynthetic process GO:0042035 108 66 1,000 0,0230687 0,07376549 ! steroid hormone receptor signaling pathway GO:0030518 146 66 1,000 0,0230687 0,07366907 ! extracellular matrix organization GO:0030198 146 68 1,000 0,02438726 0,07777816 ! detection of external stimulus GO:0009581 102 68 1,000 0,02438726 0,07767675 ! adaptive immune response GO:0002250 126 68 1,000 0,02438726 0,07757561 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! tRNA transcription GO:0009304 17 7 0,000 0,02455403 0,07800453 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02455403 0,07790323 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02455403 0,07780219 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02455403 0,07770141 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02455403 0,07760089 ! sleep GO:0030431 16 7 0,000 0,02455403 0,07750063 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02455403 0,07740063 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02455403 0,07730088 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02455403 0,0772014 ! prostate gland development GO:0030850 14 7 0,000 0,02455403 0,07710217 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02455403 0,07700319 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02455403 0,07690447 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02455403 0,076806 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02455403 0,07670778 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02455403 0,07660981 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02455403 0,0765121 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02455403 0,07641463 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02455403 0,07631741 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02455403 0,07622044 ! glycolipid transport GO:0046836 11 7 0,000 0,02455403 0,07612371 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02455403 0,07602723 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,02455403 0,07593099 ! neuron adhesion GO:0007158 14 7 0,000 0,02455403 0,075835 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02455403 0,07573925 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02455403 0,07564374 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02455403 0,07554847 ! mRNA stabilization GO:0048255 18 7 0,000 0,02455403 0,07545344 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,02455403 0,07535865 ! fibril organization GO:0043206 17 7 0,000 0,02455403 0,0752641 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,02455403 0,07516978 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02455403 0,0750757 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02455403 0,07498186 ! lipoprotein transport GO:0042953 14 7 0,000 0,02455403 0,07488825 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02455403 0,07479487 ! rhythmic behavior GO:0007622 17 7 0,000 0,02455403 0,07470172 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02455403 0,07460881 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02455403 0,07451613 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02455403 0,07442368 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02455403 0,07433146 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02455403 0,07423946 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02455403 0,07414769 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02455403 0,07405615 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02455403 0,07396484 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02455403 0,07387375 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02455403 0,07378288 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02455403 0,07369224 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02455403 0,07360182 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02455403 0,07351162 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02455403 0,07342165 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02455403 0,07333189 ! spinal cord patterning GO:0021511 14 7 0,000 0,02455403 0,07324235 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02455403 0,07315303 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02455403 0,07306393 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02455403 0,07297504 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02455403 0,07288637 ! adrenal gland development GO:0030325 17 7 0,000 0,02455403 0,07279792 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02455403 0,07270968 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02455403 0,07262165 ! ovulation GO:0030728 10 7 0,000 0,02455403 0,07253384 ! adenohypophysis development GO:0021984 11 7 0,000 0,02455403 0,07244624 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02455403 0,07235885 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02455403 0,07227167 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02455403 0,0721847 ! microtubule nucleation GO:0007020 21 7 0,000 0,02455403 0,07209794 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02455403 0,07201139 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02455403 0,07192504 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02455403 0,0718389 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02455403 0,07175297 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02455403 0,07166725 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02455403 0,07158172 ! galactose metabolic process GO:0006012 13 7 0,000 0,02455403 0,07149641 ! vesicle fusion GO:0006906 20 7 0,000 0,02455403 0,07141129 ! response to dietary excess GO:0002021 8 7 0,000 0,02455403 0,07132638 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02455403 0,07124167 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02455403 0,07115716 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02455403 0,07107285 ! organ growth GO:0035265 15 7 0,000 0,02455403 0,07098874 ! nucleoside transport GO:0015858 11 7 0,000 0,02455403 0,07090483 ! nucleoside salvage GO:0043174 11 7 0,000 0,02455403 0,07082112 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02455403 0,0707376 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02455403 0,07065428 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02455403 0,07057116 ! parturition GO:0007567 16 7 0,000 0,02455403 0,07048823 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02455403 0,0704055 ! rRNA modification GO:0000154 14 7 0,000 0,02455403 0,07032296 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02455403 0,07024061 ! spindle checkpoint GO:0031577 16 7 0,000 0,02455403 0,07015846 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02455403 0,0700765 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02455403 0,06999473 ! monocyte differentiation GO:0030224 16 7 0,000 0,02455403 0,06991315 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02455403 0,06983176 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02455403 0,06975056 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02455403 0,06966955 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02455403 0,06958873 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02455403 0,06950809 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02455403 0,06942764 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02455403 0,06934738 ! eating behavior GO:0042755 8 7 0,000 0,02455403 0,0692673 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02455403 0,06918741 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02455403 0,0691077 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02455403 0,06902818 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02455403 0,06894883 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,02455403 0,06886967 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02455403 0,06879069 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02455403 0,0687119 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02455403 0,06863328 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02455403 0,06855484 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02455403 0,06847658 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02455403 0,0683985 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,02455403 0,0683206 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02455403 0,06824287 ! histone ubiquitination GO:0016574 9 7 0,000 0,02455403 0,06816532 ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02455403 0,06808795 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02455403 0,06801075 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02455403 0,06793373 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02455403 0,06785688 ! transcription termination GO:0006353 14 7 0,000 0,02455403 0,06778021 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02455403 0,06770371 ! anaphase GO:0051322 18 7 0,000 0,02455403 0,06762738 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02455403 0,06755122 ! axonal fasciculation GO:0007413 19 7 0,000 0,02455403 0,06747524 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02455403 0,06739942 GO:0045839|negative regulation of mitosis, ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02455403 0,06732378 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02455403 0,0672483 ! diuresis GO:0030146 12 7 0,000 0,02455403 0,067173 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02455403 0,06709786 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02455403 0,06702289 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02455403 0,06694809 ! antibiotic transport GO:0042891 9 7 0,000 0,02455403 0,06687345 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02455403 0,06679898 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02455403 0,06672468 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02455403 0,06665054 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02455403 0,06657656 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02455403 0,06650276 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02455403 0,06642911 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02455403 0,06635563 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02455403 0,0662823 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02455403 0,06620914 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02455403 0,06613615 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02455403 0,06606331 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02455403 0,06599063 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02455403 0,06591812 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02455403 0,06584576 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02455403 0,06577356 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02455403 0,06570152 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02455403 0,06562963 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02455403 0,06555791 ! muscle adaptation GO:0043500 13 7 0,000 0,02455403 0,06548634 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02455403 0,06541492 ! retina homeostasis GO:0001895 12 7 0,000 0,02455403 0,06534367 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02455403 0,06527256 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02455403 0,06520161 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02455403 0,06513082 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02455403 0,06506018 ! negative regulation of protein kinase activity GO:0006469 144 69 1,000 0,02505788 0,0663233 ! lung development GO:0030324 165 69 1,000 0,02505788 0,06625152 ! urogenital system development GO:0001655 149 69 1,000 0,02505788 0,0661799 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,02505788 0,06610843 ! cell redox homeostasis GO:0045454 114 70 1,000 0,02573599 0,06782419 ! cell cycle checkpoint GO:0000075 145 71 1,000 0,02642152 0,0695558 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 1,000 0,02642152 0,06948093 ! carbohydrate transport GO:0008643 114 72 1,000 0,02711442 0,07122637 ! respiratory tube development GO:0030323 171 72 1,000 0,02711442 0,07114986 ! actin filament organization GO:0007015 167 72 1,000 0,02711442 0,07107352 ! humoral immune response GO:0006959 115 73 1,000 0,02781461 0,07283076 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02801257 0,07327056 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02801257 0,07319219 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,02801257 0,073114 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02801257 0,07303597 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02801257 0,0729581 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02801257 0,07288041 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02801257 0,07280287 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02801257 0,07272551 ! male meiosis GO:0007140 9 8 0,000 0,02801257 0,0726483 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02801257 0,07257126 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02801257 0,07249439 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02801257 0,07241767 ! meiotic prophase I GO:0007128 14 8 0,000 0,02801257 0,07234112 ! response to zinc ion GO:0010043 12 8 0,000 0,02801257 0,07226473 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02801257 0,0721885 ! oligopeptide transport GO:0006857 16 8 0,000 0,02801257 0,07211244 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02801257 0,07203653 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02801257 0,07196078 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02801257 0,07188519 ! signal peptide processing GO:0006465 12 8 0,000 0,02801257 0,07180976 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02801257 0,07173449 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02801257 0,07165937 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02801257 0,07158442 ! succinate metabolic process GO:0006105 17 8 0,000 0,02801257 0,07150962 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02801257 0,07143497 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02801257 0,07136048 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02801257 0,07128615 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02801257 0,07121197 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02801257 0,07113794 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02801257 0,07106407 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02801257 0,07099035 ! reflex GO:0060004 17 8 0,000 0,02801257 0,07091679 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02801257 0,07084338 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02801257 0,07077012 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02801257 0,07069701 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02801257 0,07062405 ! pigment granule organization GO:0048753 17 8 0,000 0,02801257 0,07055124 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02801257 0,07047858 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02801257 0,07040607 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02801257 0,07033371 ! histidine catabolic process GO:0006548 10 8 0,000 0,02801257 0,0702615 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02801257 0,07018944 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02801257 0,07011752 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02801257 0,07004575 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02801257 0,06997413 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02801257 0,06990266 ! melanin metabolic process GO:0006582 17 8 0,000 0,02801257 0,06983133 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02801257 0,06976014 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02801257 0,06968911 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02801257 0,06961821 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,02801257 0,06954746 ! macrophage activation GO:0042116 13 8 0,000 0,02801257 0,06947685 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02801257 0,06940639 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02801257 0,06933607 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02801257 0,06926589 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02801257 0,06919586 ! purine salvage GO:0043101 12 8 0,000 0,02801257 0,06912596 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02801257 0,06905621 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02801257 0,06898659 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02801257 0,06891712 ! osteoblast development GO:0002076 17 8 0,000 0,02801257 0,06884779 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02801257 0,0687786 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02801257 0,06870954 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02801257 0,06864062 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02801257 0,06857185 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02801257 0,06850321 ! response to UV-B GO:0010224 17 8 0,000 0,02801257 0,0684347 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02801257 0,06836634 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02801257 0,06829811 ! intermediate filament organization GO:0045109 12 8 0,000 0,02801257 0,06823001 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02801257 0,06816205 ! cellular extravasation GO:0045123 13 8 0,000 0,02801257 0,06809423 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02801257 0,06802654 ! response to antibiotic GO:0046677 11 8 0,000 0,02801257 0,06795899 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02801257 0,06789157 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02801257 0,06782428 ! DNA topological change GO:0006265 12 8 0,000 0,02801257 0,06775713 ! response to tropane GO:0014073 15 8 0,000 0,02801257 0,06769011 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,02801257 0,06762322 ! melanosome transport GO:0032402 13 8 0,000 0,02801257 0,06755647 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02801257 0,06748984 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02801257 0,06742335 ! mast cell activation GO:0045576 14 8 0,000 0,02801257 0,06735699 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02801257 0,06729076 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,02801257 0,06722466 ! gas homeostasis GO:0033483 14 8 0,000 0,02801257 0,06715869 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02801257 0,06709285 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02801257 0,06702713 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02801257 0,06696155 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02801257 0,06689609 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02801257 0,06683076 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02801257 0,06676556 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02801257 0,06670049 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02801257 0,06663554 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02801257 0,06657072 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02801257 0,06650603 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02801257 0,06644146 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02801257 0,06637701 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02801257 0,0663127 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02801257 0,0662485 ! hormone catabolic process GO:0042447 17 8 0,000 0,02801257 0,06618443 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02801257 0,06612049 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02801257 0,06605666 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02801257 0,06599296 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02801257 0,06592939 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02801257 0,06586593 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02801257 0,0658026 ! adult feeding behavior GO:0008343 10 8 0,000 0,02801257 0,06573939 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02801257 0,0656763 ! ATP catabolic process GO:0006200 11 8 0,000 0,02801257 0,06561333 ! blastocyst growth GO:0001832 19 8 0,000 0,02801257 0,06555048 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02801257 0,06548775 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02801257 0,06542515 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02801257 0,06536266 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02801257 0,06530029 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02801257 0,06523804 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02801257 0,06517591 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02801257 0,06511389 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02801257 0,065052 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02801257 0,06499022 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02801257 0,06492856 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02801257 0,06486702 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02801257 0,06480559 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02801257 0,06474428 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02801257 0,06468308 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02801257 0,064622 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02801257 0,06456104 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,02801257 0,06450019 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02801257 0,06443946 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02801257 0,06437884 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02801257 0,06431833 ! respiratory system development GO:0060541 175 74 1,000 0,02852205 0,06542665 ! leukocyte mediated immunity GO:0002443 136 75 1,000 0,02923668 0,06700301 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,03068724 0,07026142 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,03068724 0,07019563 ! regulation of catabolic process GO:0009894 173 77 1,000 0,03068724 0,07012997 ! lipoprotein metabolic process GO:0042157 147 78 1,000 0,03142307 0,07174444 ! antigen processing and presentation GO:0019882 117 78 1,000 0,03142307 0,07167746 ! axon extension GO:0048675 16 9 0,000 0,03145894 0,07169235 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03145894 0,07162553 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03145894 0,07155884 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03145894 0,07149228 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03145894 0,07142584 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03145894 0,07135952 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03145894 0,07129332 ! reproductive behavior GO:0019098 22 9 0,000 0,03145894 0,07122725 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03145894 0,0711613 ! Golgi to endosome transport GO:0006895 25 9 0,000 0,03145894 0,07109547 ! UTP metabolic process GO:0046051 10 9 0,000 0,03145894 0,07102976 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,03145894 0,07096417 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,03145894 0,07089871 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03145894 0,07083336 ! artery development GO:0060840 25 9 0,000 0,03145894 0,07076814 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03145894 0,07070303 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03145894 0,07063805 ! equilibrioception GO:0050957 20 9 0,000 0,03145894 0,07057319 ! chemosensory behavior GO:0007635 21 9 0,000 0,03145894 0,07050844 ! microtubule bundle formation GO:0001578 22 9 0,000 0,03145894 0,07044381 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,03145894 0,0703793 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03145894 0,07031491 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03145894 0,07025064 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03145894 0,07018648 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03145894 0,07012244 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03145894 0,07005852 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03145894 0,06999472 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03145894 0,06993103 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03145894 0,06986745 ! protein targeting to ER GO:0045047 25 9 0,000 0,03145894 0,069804 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03145894 0,06974065 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,03145894 0,06967742 ! T cell selection GO:0045058 27 9 0,000 0,03145894 0,06961431 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03145894 0,06955131 ! glycine catabolic process GO:0006546 15 9 0,000 0,03145894 0,06948843 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03145894 0,06942565 ! endosome organization GO:0007032 20 9 0,000 0,03145894 0,069363 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03145894 0,06930045 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03145894 0,06923802 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03145894 0,0691757 ! mannose metabolic process GO:0006013 13 9 0,000 0,03145894 0,06911349 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03145894 0,06905139 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03145894 0,06898941 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03145894 0,06892753 ! receptor clustering GO:0043113 20 9 0,000 0,03145894 0,06886577 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03145894 0,06880412 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03145894 0,06874257 ! retinol metabolic process GO:0042572 20 9 0,000 0,03145894 0,06868114 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03145894 0,06861982 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03145894 0,06855861 GO:0007351|tripartite regional subdivision, ! oligodendrocyte development GO:0014003 11 9 0,000 0,03145894 0,0684975 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,03145894 0,06843651 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03145894 0,06837562 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03145894 0,06831484 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03145894 0,06825417 ! response to amine stimulus GO:0014075 13 9 0,000 0,03145894 0,06819361 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03145894 0,06813315 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03145894 0,06807281 ! erythrocyte development GO:0048821 17 9 0,000 0,03145894 0,06801257 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03145894 0,06795243 ! renal water homeostasis GO:0003091 15 9 0,000 0,03145894 0,0678924 ! postreplication repair GO:0006301 25 9 0,000 0,03145894 0,06783248 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03145894 0,06777266 ! icosanoid secretion GO:0032309 15 9 0,000 0,03145894 0,06771295 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03145894 0,06765334 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03145894 0,06759384 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03145894 0,06753445 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03145894 0,06747515 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03145894 0,06741596 ! sterol catabolic process GO:0016127 14 9 0,000 0,03145894 0,06735688 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,03145894 0,0672979 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03145894 0,06723902 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03145894 0,06718024 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,03145894 0,06712157 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,03145894 0,067063 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03145894 0,06700453 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,03145894 0,06694617 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03145894 0,0668879 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03145894 0,06682974 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03145894 0,06677168 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03145894 0,06671371 ! purine base metabolic process GO:0006144 25 9 0,000 0,03145894 0,06665585 ! pigment granule transport GO:0051904 17 9 0,000 0,03145894 0,06659809 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03145894 0,06654043 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03145894 0,06648287 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03145894 0,06642541 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03145894 0,06636805 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03145894 0,06631078 ! mitochondrion localization GO:0051646 18 9 0,000 0,03145894 0,06625362 ! blood coagulation GO:0007596 151 79 1,000 0,03216584 0,06768402 GO:0050817|coagulation, ! activation of protein kinase activity GO:0032147 170 80 1,000 0,03291551 0,06920188 ! muscle cell differentiation GO:0042692 178 81 1,000 0,03367201 0,07073149 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,03367201 0,07067072 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,0348932 0,07317088 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,0348932 0,07310813 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,0348932 0,07304548 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,0348932 0,07298294 ! associative learning GO:0008306 21 10 0,000 0,0348932 0,07292051 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,0348932 0,07285819 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,0348932 0,07279597 ! phosphate transport GO:0006817 24 10 0,000 0,0348932 0,07273386 ! cell volume homeostasis GO:0006884 17 10 0,000 0,0348932 0,07267185 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,0348932 0,07260995 ! CTP metabolic process GO:0046036 11 10 0,000 0,0348932 0,07254815 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,0348932 0,07248646 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,0348932 0,07242488 ! GTP metabolic process GO:0046039 11 10 0,000 0,0348932 0,07236339 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,0348932 0,07230202 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,0348932 0,07224074 ! social behavior GO:0035176 29 10 0,000 0,0348932 0,07217958 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,0348932 0,07211851 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,0348932 0,07205755 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,0348932 0,07199669 ! androgen metabolic process GO:0008209 17 10 0,000 0,0348932 0,07193593 ! phospholipid efflux GO:0033700 19 10 0,000 0,0348932 0,07187528 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,0348932 0,07181472 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,0348932 0,07175427 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,0348932 0,07169393 ! lung alveolus development GO:0048286 26 10 0,000 0,0348932 0,07163368 ! pathogenesis GO:0009405 17 10 0,000 0,0348932 0,07157353 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0348932 0,07151349 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,0348932 0,07145354 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,0348932 0,0713937 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,0348932 0,07133396 ! endoderm development GO:0007492 18 10 0,000 0,0348932 0,07127431 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,0348932 0,07121477 ! arginine catabolic process GO:0006527 17 10 0,000 0,0348932 0,07115532 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,0348932 0,07109598 ! proline metabolic process GO:0006560 13 10 0,000 0,0348932 0,07103673 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,0348932 0,07097758 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,0348932 0,07091853 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 34 10 0,000 0,0348932 0,07085958 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,0348932 0,07080073 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,0348932 0,07074197 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,0348932 0,07068332 ! B cell proliferation GO:0042100 19 10 0,000 0,0348932 0,07062475 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,0348932 0,07056629 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,0348932 0,07050792 ! multicellular organism growth GO:0035264 19 10 0,000 0,0348932 0,07044965 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,0348932 0,07039148 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,0348932 0,0703334 ! ruffle organization GO:0031529 17 10 0,000 0,0348932 0,07027541 ! epithelial cell development GO:0002064 21 10 0,000 0,0348932 0,07021753 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,0348932 0,07015974 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,0348932 0,07010204 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,0348932 0,07004444 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,0348932 0,06998693 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,0348932 0,06992951 GO:0030204|chondroitin sulfate metabolic process, ! motor axon guidance GO:0008045 22 10 0,000 0,0348932 0,0698722 ! copper ion homeostasis GO:0055070 13 10 0,000 0,0348932 0,06981497 ! regulation of bone resorption GO:0045124 25 10 0,000 0,0348932 0,06975784 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,0348932 0,0697008 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,0348932 0,06964385 ! segment specification GO:0007379 15 10 0,000 0,0348932 0,069587 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,0348932 0,06953024 ! blastoderm segmentation GO:0007350 19 10 0,000 0,0348932 0,06947358 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,0348932 0,069417 ! DNA ligation GO:0006266 18 10 0,000 0,0348932 0,06936052 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,0348932 0,06930413 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,0348932 0,06924783 ! melanosome localization GO:0032400 16 10 0,000 0,0348932 0,06919162 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,0348932 0,06913551 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,0348932 0,06907948 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,0348932 0,06902355 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,0348932 0,0689677 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,0348932 0,06891195 ! induction of an organ GO:0001759 17 10 0,000 0,0348932 0,06885628 ! mRNA cleavage GO:0006379 18 10 0,000 0,0348932 0,06880071 ! protein sumoylation GO:0016925 17 10 0,000 0,0348932 0,06874522 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,0348932 0,06868983 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,0348932 0,06863452 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0348932 0,06857931 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,0348932 0,06852418 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,0348932 0,06846914 ! salivary gland development GO:0007431 28 10 0,000 0,0348932 0,06841419 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,0348932 0,06835932 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,0348932 0,06830455 ! midbrain development GO:0030901 14 10 0,000 0,0348932 0,06824986 ! musculoskeletal movement GO:0050881 16 10 0,000 0,0348932 0,06819526 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,0348932 0,06814075 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,0348932 0,06808632 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,0348932 0,06803199 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,0348932 0,06797773 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,0348932 0,06792357 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,0348932 0,06786949 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,0348932 0,0678155 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,0348932 0,06776159 ! detection of calcium ion GO:0005513 24 10 0,000 0,0348932 0,06770777 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,0348932 0,06765403 ! blastocyst formation GO:0001825 18 10 0,000 0,0348932 0,06760038 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,0348932 0,06754681 ! cerebellar cortex development GO:0021695 16 10 0,000 0,0348932 0,06749333 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,0348932 0,06743994 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,0348932 0,06738662 ! response to nicotine GO:0035094 20 10 0,000 0,0348932 0,0673334 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,0348932 0,06728025 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,0348932 0,06722719 ! response to drug GO:0042493 149 83 1,000 0,03520529 0,06777504 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,03520529 0,06772167 GO:0045937|positive regulation of phosphate metabolic process, ! response to metal ion GO:0010038 158 84 1,000 0,03598195 0,06916122 ! digestion GO:0007586 130 84 1,000 0,03598195 0,06910685 ! hemostasis GO:0007599 165 85 1,000 0,03676523 0,07055574 ! cholesterol metabolic process GO:0008203 148 85 1,000 0,03676523 0,07050036 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,03676523 0,07044506 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,03831537 0,07335771 ! respiratory burst GO:0045730 17 11 0,000 0,03831537 0,07330027 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03831537 0,07324291 ! neuron fate specification GO:0048665 18 11 0,000 0,03831537 0,07318565 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03831537 0,07312847 ! thyroid gland development GO:0030878 26 11 0,000 0,03831537 0,07307139 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 0,03831537 0,07301439 ! synapsis GO:0007129 14 11 0,000 0,03831537 0,07295748 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03831537 0,07290066 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03831537 0,07284393 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,03831537 0,07278728 ! response to pain GO:0048265 27 11 0,000 0,03831537 0,07273073 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03831537 0,07267426 ! blood vessel remodeling GO:0001974 30 11 0,000 0,03831537 0,07261788 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,03831537 0,07256158 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,03831537 0,07250538 ! bone resorption GO:0045453 16 11 0,000 0,03831537 0,07244926 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03831537 0,07239323 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03831537 0,07233728 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03831537 0,07228142 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03831537 0,07222565 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03831537 0,07216996 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03831537 0,07211436 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03831537 0,07205885 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03831537 0,07200342 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03831537 0,07194807 ! UV protection GO:0009650 20 11 0,000 0,03831537 0,07189281 ! adult heart development GO:0007512 16 11 0,000 0,03831537 0,07183764 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03831537 0,07178255 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03831537 0,07172754 ! macroautophagy GO:0016236 19 11 0,000 0,03831537 0,07167262 ! temperature homeostasis GO:0001659 18 11 0,000 0,03831537 0,07161778 ! behavioral fear response GO:0001662 27 11 0,000 0,03831537 0,07156303 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03831537 0,07150836 ! negative regulation of ossification GO:0030279 27 11 0,000 0,03831537 0,07145377 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,03831537 0,07139927 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03831537 0,07134485 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,03831537 0,07129051 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03831537 0,07123626 ! regulation of organ growth GO:0046620 14 11 0,000 0,03831537 0,07118209 ! pigment granule localization GO:0051875 20 11 0,000 0,03831537 0,071128 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03831537 0,07107399 ! vasoconstriction GO:0042310 20 11 0,000 0,03831537 0,07102006 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03831537 0,07096622 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03831537 0,07091246 ! embryonic axis specification GO:0000578 19 11 0,000 0,03831537 0,07085878 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03831537 0,07080518 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03831537 0,07075166 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03831537 0,07069822 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03831537 0,07064486 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,03831537 0,07059159 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03831537 0,07053839 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03831537 0,07048527 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03831537 0,07043224 ! prophase GO:0051324 17 11 0,000 0,03831537 0,07037928 ! neuroblast proliferation GO:0007405 25 11 0,000 0,03831537 0,0703264 ! nucleosome positioning GO:0016584 15 11 0,000 0,03831537 0,07027361 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03831537 0,07022089 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03831537 0,07016825 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03831537 0,07011569 ! apical protein localization GO:0045176 18 11 0,000 0,03831537 0,07006321 ! acid secretion GO:0046717 20 11 0,000 0,03831537 0,0700108 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03831537 0,06995848 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03831537 0,06990623 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,03831537 0,06985406 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03831537 0,06980197 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03831537 0,06974996 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03831537 0,06969802 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03831537 0,06964616 ! cholesterol efflux GO:0033344 21 11 0,000 0,03831537 0,06959438 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03831537 0,06954268 ! oocyte development GO:0048599 20 11 0,000 0,03831537 0,06949105 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03831537 0,0694395 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03831537 0,06938802 ! embryonic gut development GO:0048566 19 11 0,000 0,03831537 0,06933663 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03831537 0,0692853 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03831537 0,06923406 ! activation of innate immune response GO:0002218 16 11 0,000 0,03831537 0,06918289 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03831537 0,06913179 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03831537 0,06908077 ! lysogeny GO:0030069 22 11 0,000 0,03831537 0,06902983 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03831537 0,06897896 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03831537 0,06892816 ! amine biosynthetic process GO:0009309 146 88 1,000 0,03915415 0,07038527 ! tube morphogenesis GO:0035239 194 89 1,000 0,0399633 0,07178702 ! response to inorganic substance GO:0010035 173 90 1,000 0,04077879 0,07319808 ! gland development GO:0048732 220 91 1,000 0,04160056 0,07461832 ! defense response to bacterium GO:0042742 112 91 1,000 0,04160056 0,07456358 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,0417255 0,0747327 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,0417255 0,07467795 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,0417255 0,07462328 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,0417255 0,07456869 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,0417255 0,07451418 ! protein complex disassembly GO:0043241 28 12 0,000 0,0417255 0,07445975 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,0417255 0,0744054 ! hippocampus development GO:0021766 29 12 0,000 0,0417255 0,07435113 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,0417255 0,07429694 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,0417255 0,07424283 ! T cell proliferation GO:0042098 32 12 0,000 0,0417255 0,07418879 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,0417255 0,07413484 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,0417255 0,07408096 ! ventral spinal cord development GO:0021517 25 12 0,000 0,0417255 0,07402716 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,0417255 0,07397344 ! drug transport GO:0015893 16 12 0,000 0,0417255 0,0739198 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,0417255 0,07386623 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,0417255 0,07381274 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,0417255 0,07375933 ! mitotic spindle organization GO:0007052 23 12 0,000 0,0417255 0,073706 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,0417255 0,07365275 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,0417255 0,07359957 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,0417255 0,07354646 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,0417255 0,07349344 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0417255 0,07344049 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,0417255 0,07338762 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,0417255 0,07333482 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,0417255 0,0732821 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,0417255 0,07322945 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,0417255 0,07317688 ! snRNA metabolic process GO:0016073 30 12 0,000 0,0417255 0,07312439 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,0417255 0,07307197 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,0417255 0,07301963 ! cranial nerve development GO:0021545 23 12 0,000 0,0417255 0,07296736 ! fucose catabolic process GO:0019317 25 12 0,000 0,0417255 0,07291516 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,0417255 0,07286304 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,0417255 0,072811 ! autonomic nervous system development GO:0048483 24 12 0,000 0,0417255 0,07275903 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,0417255 0,07270713 ! zymogen activation GO:0031638 18 12 0,000 0,0417255 0,07265531 ! T cell homeostasis GO:0043029 28 12 0,000 0,0417255 0,07260356 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,0417255 0,07255189 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,0417255 0,07250028 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,0417255 0,07244876 ! oocyte differentiation GO:0009994 21 12 0,000 0,0417255 0,0723973 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,0417255 0,07234592 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,0417255 0,07229461 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,0417255 0,07224337 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,0417255 0,07219221 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,0417255 0,07214112 ! defense response to fungus GO:0050832 15 12 0,000 0,0417255 0,0720901 ! developmental induction GO:0031128 22 12 0,000 0,0417255 0,07203915 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,0417255 0,07198828 ! lamellipodium assembly GO:0030032 24 12 0,000 0,0417255 0,07193747 ! response to cold GO:0009409 17 12 0,000 0,0417255 0,07188674 ! establishment of cell polarity GO:0030010 21 12 0,000 0,0417255 0,07183608 ! regulation of synapse organization GO:0050807 18 12 0,000 0,0417255 0,07178549 ! localization within membrane GO:0051668 26 12 0,000 0,0417255 0,07173498 ! sterol metabolic process GO:0016125 166 94 1,000 0,04410299 0,07576905 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,04494933 0,07716881 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,04512364 0,07741366 ! cGMP metabolic process GO:0046068 18 13 0,000 0,04512364 0,07735933 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,04512364 0,07730508 ! regulation of chemokine production GO:0032642 18 13 0,000 0,04512364 0,07725091 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,04512364 0,07719681 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,04512364 0,07714279 ! peroxisomal transport GO:0043574 28 13 0,000 0,04512364 0,07708884 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,04512364 0,07703497 ! cartilage condensation GO:0001502 22 13 0,000 0,04512364 0,07698118 ! organelle fusion GO:0048284 36 13 0,000 0,04512364 0,07692746 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,04512364 0,07687381 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,04512364 0,07682024 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,04512364 0,07676675 ! endocrine pancreas development GO:0031018 25 13 0,000 0,04512364 0,07671332 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,04512364 0,07665998 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,04512364 0,0766067 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,04512364 0,07655351 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,04512364 0,07650038 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,04512364 0,07644733 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,04512364 0,07639435 ! methionine metabolic process GO:0006555 31 13 0,000 0,04512364 0,07634145 ! plasma membrane organization GO:0007009 27 13 0,000 0,04512364 0,07628861 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,04512364 0,07623586 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,04512364 0,07618317 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,04512364 0,07613056 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,04512364 0,07607802 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,04512364 0,07602555 ! exocrine system development GO:0035272 34 13 0,000 0,04512364 0,07597315 ! asymmetric protein localization GO:0008105 24 13 0,000 0,04512364 0,07592083 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,04512364 0,07586858 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,04512364 0,0758164 ! L-glutamate transport GO:0015813 30 13 0,000 0,04512364 0,07576429 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,04512364 0,07571226 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,04512364 0,07566029 ! protein homotetramerization GO:0051289 24 13 0,000 0,04512364 0,0756084 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,04512364 0,07555658 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,04512364 0,07550483 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,04512364 0,07545315 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,04512364 0,07540154 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,04512364 0,07535 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,04512364 0,07529853 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 0,04512364 0,07524713 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,04512364 0,0751958 ! histone methylation GO:0016571 29 13 0,000 0,04512364 0,07514454 ! chromatin silencing GO:0006342 29 13 0,000 0,04512364 0,07509336 ! gland morphogenesis GO:0022612 31 13 0,000 0,04512364 0,07504224 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,04512364 0,07499119 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,04512364 0,07494021 ! regulation of epidermis development GO:0045682 19 13 0,000 0,04512364 0,0748893 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,04512364 0,07483846 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,04512364 0,07478768 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,04512364 0,07473698 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,04512364 0,07468635 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,04512364 0,07463578 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,04512364 0,07458528 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,04512364 0,07453485 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,04512364 0,07448449 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,04512364 0,0744342 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,04512364 0,07438397 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,04512364 0,07433381 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,04512364 0,07428372 ! insulin secretion GO:0030073 24 13 0,000 0,04512364 0,0742337 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,04512364 0,07418375 ! acrosome reaction GO:0007340 19 13 0,000 0,04512364 0,07413386 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,04512364 0,07408404 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,04512364 0,07403428 ! biogenic amine metabolic process GO:0006576 162 97 1,000 0,04666 0,07650361 ! transcription initiation GO:0006352 171 97 1,000 0,04666 0,0764523 ! rRNA transcription GO:0009303 28 14 0,000 0,04850982 0,07942995 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,04850982 0,07937675 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,04850982 0,07932362 ! water transport GO:0006833 21 14 0,000 0,04850982 0,07927056 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,04850982 0,07921757 ! non-recombinational repair GO:0000726 29 14 0,000 0,04850982 0,07916466 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,04850982 0,07911181 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,04850982 0,07905903 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,04850982 0,07900633 ! RNA polyadenylation GO:0043631 32 14 0,000 0,04850982 0,07895369 ! lipid localization GO:0010876 32 14 0,000 0,04850982 0,07890112 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,04850982 0,07884863 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,04850982 0,0787962 ! regulated secretory pathway GO:0045055 24 14 0,000 0,04850982 0,07874385 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,04850982 0,07869156 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,04850982 0,07863934 ! arginine metabolic process GO:0006525 21 14 0,000 0,04850982 0,07858719 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,04850982 0,07853512 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,04850982 0,07848311 ! regulation of heart rate GO:0002027 25 14 0,000 0,04850982 0,07843116 ! fear response GO:0042596 34 14 0,000 0,04850982 0,07837929 ! organic alcohol transport GO:0015850 29 14 0,000 0,04850982 0,07832749 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,04850982 0,07827575 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,04850982 0,07822409 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,04850982 0,07817249 ! neutral amino acid transport GO:0015804 28 14 0,000 0,04850982 0,07812096 ! bone mineralization GO:0030282 18 14 0,000 0,04850982 0,07806949 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,04850982 0,0780181 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,04850982 0,07796677 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,04850982 0,07791551 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,04850982 0,07786432 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,04850982 0,07781319 ! ribosome assembly GO:0042255 18 14 0,000 0,04850982 0,07776213 ! cerebellum development GO:0021549 23 14 0,000 0,04850982 0,07771114 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,04850982 0,07766022 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,04850982 0,07760936 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,04850982 0,07755857 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,04850982 0,07750784 ! NADP metabolic process GO:0006739 24 14 0,000 0,04850982 0,07745718 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,04850982 0,07740659 ! oxygen transport GO:0015671 22 14 0,000 0,04850982 0,07735606 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,04850982 0,0773056 ! male genitalia development GO:0030539 26 14 0,000 0,04850982 0,07725521 ! regulation of RNA stability GO:0043487 33 14 0,000 0,04850982 0,07720488 ! regulation of axon extension GO:0030516 43 14 0,000 0,04850982 0,07715462 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,04850982 0,07710442 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,04850982 0,07705428 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,04927018 0,0782112 GO:0060538|skeletal muscle organ development, ! mRNA transport GO:0051028 185 100 1,000 0,04927018 0,07816042 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,05188409 0,08225362 ! lactation GO:0007595 30 15 0,000 0,05188409 0,08220028 ! reproductive cellular process GO:0048610 22 15 0,000 0,05188409 0,082147 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,05188409 0,0820938 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,05188409 0,08204066 ! superoxide anion generation GO:0042554 22 15 0,000 0,05188409 0,0819876 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,05188409 0,0819346 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,05188409 0,08188167 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,05188409 0,08182881 ! copper ion transport GO:0006825 22 15 0,000 0,05188409 0,08177602 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,05188409 0,08172329 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,05188409 0,08167064 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,05188409 0,08161805 ! sulfate transport GO:0008272 27 15 0,000 0,05188409 0,08156553 ! response to cAMP GO:0051591 25 15 0,000 0,05188409 0,08151307 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,05188409 0,08146069 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,05188409 0,08140837 ! response to hexose stimulus GO:0009746 25 15 0,000 0,05188409 0,08135612 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,05188409 0,08130393 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,05188409 0,08125181 ! vesicle coating GO:0006901 38 15 0,000 0,05188409 0,08119976 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,05188409 0,08114778 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,05188409 0,08109586 ! regulation of exocytosis GO:0017157 26 15 0,000 0,05188409 0,08104401 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,05188409 0,08099222 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,05188409 0,0809405 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,05188409 0,08088885 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,05188409 0,08083726 ! regulation of vasodilation GO:0042312 27 15 0,000 0,05188409 0,08078574 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,05188409 0,08073428 ! histone deacetylation GO:0016575 24 15 0,000 0,05188409 0,08068289 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,05188409 0,08063157 ! water homeostasis GO:0030104 28 15 0,000 0,05188409 0,08058031 ! cofactor transport GO:0051181 30 15 0,000 0,05188409 0,08052912 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,05188409 0,08047799 ! muscle maintenance GO:0046716 26 15 0,000 0,05188409 0,08042692 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,05188409 0,08037592 ! dopamine metabolic process GO:0042417 35 15 0,000 0,05188409 0,08032499 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,05188409 0,08027411 ! heme biosynthetic process GO:0006783 33 15 0,000 0,05188409 0,08022331 ! cell killing GO:0001906 32 15 0,000 0,05188409 0,08017257 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,05188409 0,08012189 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,05188409 0,08007127 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,05188409 0,08002072 ! actin filament polymerization GO:0030041 27 15 0,000 0,05188409 0,07997024 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,05188409 0,07991982 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,05524649 0,08504547 ! positive regulation of cell size GO:0045793 29 16 0,000 0,05524649 0,08499192 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,05524649 0,08493843 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,05524649 0,08488501 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,05524649 0,08483166 ! bone remodeling GO:0046849 28 16 0,000 0,05524649 0,08477837 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,05524649 0,08472515 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05524649 0,084672 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,05524649 0,08461891 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,05524649 0,08456589 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,05524649 0,08451294 ! startle response GO:0001964 28 16 0,000 0,05524649 0,08446005 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,05524649 0,08440723 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,05524649 0,08435448 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,05524649 0,08430179 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,05524649 0,08424917 ! protein polyubiquitination GO:0000209 41 16 0,000 0,05524649 0,08419661 ! glutamate metabolic process GO:0006536 25 16 0,000 0,05524649 0,08414412 ! pituitary gland development GO:0021983 30 16 0,000 0,05524649 0,08409169 ! response to osmotic stress GO:0006970 27 16 0,000 0,05524649 0,08403933 ! lysosomal transport GO:0007041 31 16 0,000 0,05524649 0,08398703 ! fructose metabolic process GO:0006000 25 16 0,000 0,05524649 0,0839348 ! L-amino acid transport GO:0015807 33 16 0,000 0,05524649 0,08388264 ! stem cell development GO:0048864 46 16 0,000 0,05524649 0,08383054 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,05524649 0,0837785 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,05524649 0,08372653 ! negative regulation of immune response GO:0050777 38 16 0,000 0,05524649 0,08367462 ! axon cargo transport GO:0008088 46 16 0,000 0,05524649 0,08362278 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,05524649 0,083571 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,05524649 0,08351928 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,05524649 0,08346763 ! neuron recognition GO:0008038 40 16 0,000 0,05524649 0,08341605 ! mRNA splice site selection GO:0006376 44 16 0,000 0,05524649 0,08336452 ! tissue regeneration GO:0042246 27 16 0,000 0,05524649 0,08331306 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,05524649 0,08326167 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,05524649 0,08321033 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,05524649 0,08315907 ! biomineral formation GO:0031214 22 16 0,000 0,05524649 0,08310786 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,05524649 0,08305672 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,05524649 0,08300564 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,05524649 0,08295462 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,05524649 0,08290366 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,05524649 0,08285277 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,05524649 0,08280194 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,05524649 0,08275117 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,05524649 0,08270047 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! peptide hormone processing GO:0016486 27 16 0,000 0,05524649 0,08264982 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,05859705 0,08760869 ! metencephalon development GO:0022037 32 17 0,000 0,05859705 0,08755511 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,05859705 0,08750159 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,05859705 0,08744814 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,05859705 0,08739475 ! signal complex assembly GO:0007172 47 17 0,000 0,05859705 0,08734143 ! endothelial cell migration GO:0043542 31 17 0,000 0,05859705 0,08728817 ! gene silencing by RNA GO:0031047 38 17 0,000 0,05859705 0,08723498 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,05859705 0,08718185 ! glial cell development GO:0021782 28 17 0,000 0,05859705 0,08712879 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,05859705 0,08707579 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,05859705 0,08702286 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,05859705 0,08696999 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,05859705 0,08691718 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,05859705 0,08686444 ! myoblast differentiation GO:0045445 50 17 0,000 0,05859705 0,08681176 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,05859705 0,08675915 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,05859705 0,0867066 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,05859705 0,08665412 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,05859705 0,08660169 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,05859705 0,08654933 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,05859705 0,08649704 ! membrane budding GO:0006900 42 17 0,000 0,05859705 0,08644481 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,05859705 0,08639264 ! regulation of protein binding GO:0043393 33 17 0,000 0,05859705 0,08634053 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,05859705 0,08628849 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,05859705 0,08623651 ! genitalia development GO:0048806 32 17 0,000 0,05859705 0,08618459 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,05859705 0,08613273 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,05859705 0,08608094 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,05859705 0,08602921 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,05859705 0,08597754 ! steroid catabolic process GO:0006706 34 17 0,000 0,05859705 0,08592593 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,05859705 0,08587438 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,05859705 0,0858229 ! gas transport GO:0015669 26 17 0,000 0,05859705 0,08577148 ! organic cation transport GO:0015695 32 17 0,000 0,05859705 0,08572012 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,05859705 0,08566882 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,05859705 0,08561758 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,05859705 0,08556641 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,06193583 0,09038783 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,06193583 0,09033387 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,06193583 0,09027997 ! limbic system development GO:0021761 40 18 0,000 0,06193583 0,09022614 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,06193583 0,09017237 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,06193583 0,09011866 ! adult walking behavior GO:0007628 36 18 0,000 0,06193583 0,09006502 ! patterning of blood vessels GO:0001569 43 18 0,000 0,06193583 0,09001144 ! heart looping GO:0001947 34 18 0,000 0,06193583 0,08995793 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,06193583 0,08990448 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,06193583 0,08985109 ! centrosome cycle GO:0007098 26 18 0,000 0,06193583 0,08979776 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,06193583 0,0897445 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,06193583 0,08969131 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,06193583 0,08963817 ! glycine metabolic process GO:0006544 30 18 0,000 0,06193583 0,0895851 ! glutamine metabolic process GO:0006541 29 18 0,000 0,06193583 0,08953209 ! response to retinoic acid GO:0032526 31 18 0,000 0,06193583 0,08947914 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,06193583 0,08942626 ! DNA integration GO:0015074 32 18 0,000 0,06193583 0,08937344 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,06193583 0,08932068 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,06193583 0,08926798 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,06193583 0,08921535 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,06193583 0,08916278 ! neural crest cell migration GO:0001755 41 18 0,000 0,06193583 0,08911027 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,06193583 0,08905782 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,06193583 0,08900543 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,06193583 0,08895311 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,06193583 0,08890084 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,06193583 0,08884864 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,06193583 0,0887965 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,06193583 0,08874442 ! detection of bacterium GO:0016045 22 18 0,000 0,06193583 0,0886924 ! nerve development GO:0021675 34 18 0,000 0,06193583 0,08864044 ! defense response to virus GO:0051607 43 18 0,000 0,06193583 0,08858854 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,06193583 0,08853671 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,06193583 0,08848493 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,06526286 0,09318362 ! negative regulation of defense response GO:0031348 27 19 0,000 0,06526286 0,09312919 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,06526286 0,09307482 ! neuron maturation GO:0042551 46 19 0,000 0,06526286 0,09302052 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,06526286 0,09296628 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,06526286 0,0929121 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,06526286 0,09285799 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,06526286 0,09280394 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,06526286 0,09274995 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,06526286 0,09269603 ! memory GO:0007613 34 19 0,000 0,06526286 0,09264217 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,06526286 0,09258837 ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,06526286 0,09253463 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,06526286 0,09248096 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,06526286 0,09242734 ! cerebral cortex development GO:0021987 40 19 0,000 0,06526286 0,09237379 ! pigmentation during development GO:0048066 42 19 0,000 0,06526286 0,09232031 ! response to vitamin A GO:0033189 32 19 0,000 0,06526286 0,09226688 ! heme metabolic process GO:0042168 40 19 0,000 0,06526286 0,09221352 ! neuromuscular junction development GO:0007528 43 19 0,000 0,06526286 0,09216021 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,06526286 0,09210697 ! response to fungus GO:0009620 26 19 0,000 0,06526286 0,09205379 ! peptide cross-linking GO:0018149 39 19 0,000 0,06526286 0,09200067 ! heart process GO:0003015 32 19 0,000 0,06526286 0,09194762 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,06526286 0,09189462 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,06526286 0,09184169 ! visual learning GO:0008542 38 19 0,000 0,06526286 0,09178881 ! cellular pigmentation GO:0033059 37 19 0,000 0,06526286 0,091736 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,06526286 0,09168325 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,06526286 0,09163056 ! vitamin transport GO:0051180 31 19 0,000 0,06526286 0,09157793 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,06526286 0,09152536 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,06526286 0,09147285 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,06526286 0,09142039 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,06526286 0,09136801 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,06526286 0,09131568 ! cilium assembly GO:0042384 38 19 0,000 0,06526286 0,09126341 ! peptide hormone secretion GO:0030072 32 19 0,000 0,06526286 0,09121119 ! protein secretion GO:0009306 45 20 0,000 0,06857818 0,09578988 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,06857818 0,09573515 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,06857818 0,09568047 ! positive regulation of ossification GO:0045778 50 20 0,000 0,06857818 0,09562586 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,06857818 0,09557131 ! skin development GO:0043588 42 20 0,000 0,06857818 0,09551682 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,06857818 0,0954624 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,06857818 0,09540803 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,06857818 0,09535373 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,06857818 0,09529949 ! response to vitamin GO:0033273 36 20 0,000 0,06857818 0,09524531 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,06857818 0,0951912 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,06857818 0,09513714 ! bile acid metabolic process GO:0008206 34 20 0,000 0,06857818 0,09508315 ! retinoid metabolic process GO:0001523 34 20 0,000 0,06857818 0,09502921 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,06857818 0,09497534 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,06857818 0,09492153 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,06857818 0,09486778 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,06857818 0,09481409 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,06857818 0,09476047 ! body fluid secretion GO:0007589 33 20 0,000 0,06857818 0,0947069 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,06857818 0,09465339 ! peptide secretion GO:0002790 38 20 0,000 0,06857818 0,09459995 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,06857818 0,09454656 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,06857818 0,09449323 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,06857818 0,09443997 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,06857818 0,09438676 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,06857818 0,09433362 ! cell-cell junction organization GO:0045216 43 20 0,000 0,06857818 0,09428053 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,06857818 0,09422751 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,06857818 0,09417454 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,06857818 0,09412163 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,06857818 0,09406878 ! regulation of glucose import GO:0046324 30 20 0,000 0,06857818 0,094016 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,06857818 0,09396327 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,06857818 0,0939106 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,06857818 0,09385799 ! regulation of cell killing GO:0031341 46 21 0,000 0,07188184 0,09832438 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,07188184 0,09826936 ! hormone secretion GO:0046879 39 21 0,000 0,07188184 0,0982144 ! cAMP metabolic process GO:0046058 41 21 0,000 0,07188184 0,0981595 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,07188184 0,09810466 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,07188184 0,09804988 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,07188184 0,09799517 ! ovarian follicle development GO:0001541 39 21 0,000 0,07188184 0,09794051 ! smooth muscle contraction GO:0006939 48 21 0,000 0,07188184 0,09788592 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,07188184 0,09783139 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,07188184 0,09777692 ! plasma membrane fusion GO:0045026 33 21 0,000 0,07188184 0,09772251 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,07188184 0,09766815 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,07188184 0,09761386 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,07188184 0,09755963 ! sensory perception of pain GO:0019233 33 21 0,000 0,07188184 0,09750546 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,07188184 0,09745135 ! diencephalon development GO:0021536 36 21 0,000 0,07188184 0,09739731 ! collagen fibril organization GO:0030199 62 21 0,000 0,07188184 0,09734332 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,07188184 0,09728939 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,07188184 0,09723552 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,07188184 0,09718171 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,07188184 0,09712795 ! collagen catabolic process GO:0030574 29 21 0,000 0,07188184 0,09707426 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,07188184 0,09702063 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,07188184 0,09696706 ! sperm-egg recognition GO:0035036 23 21 0,000 0,07188184 0,09691354 ! actin filament-based movement GO:0030048 47 21 0,000 0,07188184 0,09686009 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,07517388 0,10124023 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,07517388 0,10118445 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,07517388 0,10112873 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,07517388 0,10107308 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,07517388 0,10101748 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,07517388 0,10096195 ! microtubule-based transport GO:0010970 59 22 0,000 0,07517388 0,10090647 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,07517388 0,10085106 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,07517388 0,10079571 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,07517388 0,10074042 ! vacuolar transport GO:0007034 41 22 0,000 0,07517388 0,10068519 ! central nervous system neuron development GO:0021954 47 22 0,000 0,07517388 0,10063002 ! fucose metabolic process GO:0006004 44 22 0,000 0,07517388 0,10057491 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,07517388 0,10051986 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,07517388 0,10046487 ! ureteric bud development GO:0001657 50 22 0,000 0,07517388 0,10040994 ! stem cell differentiation GO:0048863 57 22 0,000 0,07517388 0,10035507 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,07517388 0,10030026 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,07517388 0,10024551 ! cytolysis GO:0019835 27 22 0,000 0,07517388 0,10019082 ! renal system process GO:0003014 42 22 0,000 0,07517388 0,10013619 ! vasodilation GO:0042311 40 22 0,000 0,07517388 0,10008162 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,07517388 0,10002711 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,07517388 0,09997266 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 0,07517388 0,09991827 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,07517388 0,09986394 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,07517388 0,09980966 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,07517388 0,09975545 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,07517388 0,09970129 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,07517388 0,09964719 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,07517388 0,09959316 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,07517388 0,09953918 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,07517388 0,09948525 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,07517388 0,09943139 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,07517388 0,09937759 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,07517388 0,09932384 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,07517388 0,09927015 ! gut development GO:0048565 44 22 0,000 0,07517388 0,09921652 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,07517388 0,09916295 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,07517388 0,09910943 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,07517388 0,09905598 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,07845432 0,10332286 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,07845432 0,10326719 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,07845432 0,10321159 ! gluconeogenesis GO:0006094 38 23 0,000 0,07845432 0,10315604 ! glycerol metabolic process GO:0006071 40 23 0,000 0,07845432 0,10310055 ! viral genome replication GO:0019079 44 23 0,000 0,07845432 0,10304511 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,07845432 0,10298974 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,07845432 0,10293443 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,07845432 0,10287918 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,07845432 0,10282399 ! regeneration GO:0031099 42 23 0,000 0,07845432 0,10276885 ! axis specification GO:0009798 43 23 0,000 0,07845432 0,10271378 ! visual behavior GO:0007632 46 23 0,000 0,07845432 0,10265876 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,07845432 0,10260381 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,07845432 0,10254891 ! response to ethanol GO:0045471 47 23 0,000 0,07845432 0,10249407 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,07845432 0,10243929 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,07845432 0,10238457 ! peroxisome organization GO:0007031 43 23 0,000 0,07845432 0,10232991 ! lysosome organization GO:0007040 47 23 0,000 0,07845432 0,1022753 ! vesicle targeting GO:0006903 49 23 0,000 0,07845432 0,10222075 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,07845432 0,10216627 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,07845432 0,10211183 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,07845432 0,10205746 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,07845432 0,10200315 ! DNA modification GO:0006304 36 23 0,000 0,07845432 0,10194889 ! fatty acid transport GO:0015908 47 23 0,000 0,07845432 0,10189469 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,07845432 0,10184055 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,07845432 0,10178647 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,07845432 0,10173244 ! hormone transport GO:0009914 41 23 0,000 0,07845432 0,10167847 ! cell-cell recognition GO:0009988 28 23 0,000 0,07845432 0,10162456 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,07845432 0,1015707 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,07845432 0,1015169 GO:0006099|tricarboxylic acid cycle, ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,08172323 0,10569076 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,08172323 0,10563484 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,08172323 0,10557898 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,08172323 0,10552318 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,08172323 0,10546743 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,08172323 0,10541175 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,08172323 0,10535612 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 0,000 0,08172323 0,10530055 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,08172323 0,10524504 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,08172323 0,10518959 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,08172323 0,1051342 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,08172323 0,10507887 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,08172323 0,10502359 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,08172323 0,10496837 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,08172323 0,10491321 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,08172323 0,10485811 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 52 24 0,000 0,08172323 0,10480307 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,08172323 0,10474808 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,08172323 0,10469316 ! membrane depolarization GO:0051899 45 24 0,000 0,08172323 0,10463828 ! pallium development GO:0021543 56 24 0,000 0,08172323 0,10458347 ! oogenesis GO:0048477 44 24 0,000 0,08172323 0,10452872 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,08172323 0,10447402 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,08172323 0,10441938 ! regulation of oxidoreductase activity GO:0051341 48 24 0,000 0,08172323 0,10436479 ! platelet activation GO:0030168 41 24 0,000 0,08172323 0,10431027 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,08172323 0,1042558 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,08172323 0,10420138 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,08172323 0,10414703 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,08172323 0,10409273 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,08172323 0,10403848 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,08172323 0,1039843 ! regulation of amine transport GO:0051952 41 24 0,000 0,08172323 0,10393017 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,08172323 0,10387609 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,08498063 0,10796031 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,08498063 0,1079042 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,08498063 0,10784814 ! leukocyte adhesion GO:0007159 55 25 0,000 0,08498063 0,10779215 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,08498063 0,10773621 ! phototransduction GO:0007602 37 25 0,000 0,08498063 0,10768033 ! vasculogenesis GO:0001570 49 25 0,000 0,08498063 0,10762451 ! vacuole organization GO:0007033 49 25 0,000 0,08498063 0,10756874 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,08498063 0,10751304 ! receptor metabolic process GO:0043112 53 25 0,000 0,08498063 0,10745739 ! chromosome condensation GO:0030261 48 25 0,000 0,08498063 0,1074018 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,08498063 0,10734627 ! regulation of behavior GO:0050795 48 25 0,000 0,08498063 0,10729079 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,08498063 0,10723537 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,08498063 0,10718001 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,08498063 0,1071247 ! immunoglobulin production GO:0002377 62 25 0,000 0,08498063 0,10706946 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,08498063 0,10701427 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,08498063 0,10695913 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,08498063 0,10690406 ! liver development GO:0001889 55 25 0,000 0,08498063 0,10684904 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,08822657 0,1108732 ! myelination GO:0042552 50 26 0,000 0,08822657 0,1108162 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,08822657 0,11075925 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,08822657 0,11070236 ! molting cycle process GO:0022404 52 26 0,000 0,08822657 0,11064553 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! protein amino acid alkylation GO:0008213 59 26 0,000 0,08822657 0,11058876 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,08822657 0,11053205 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,08822657 0,1104754 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,08822657 0,1104188 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,08822657 0,11036226 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,08822657 0,11030578 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 0,000 0,08822657 0,11024936 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,08822657 0,110193 ! osteoblast differentiation GO:0001649 63 26 0,000 0,08822657 0,11013669 ! neural crest cell development GO:0014032 59 26 0,000 0,08822657 0,11008044 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,08822657 0,11002425 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,08822657 0,10996811 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,08822657 0,10991204 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,08822657 0,10985602 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,08822657 0,10980005 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,08822657 0,10974415 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,08822657 0,1096883 ! blastocyst development GO:0001824 50 26 0,000 0,08822657 0,1096325 ! telomere organization GO:0032200 46 26 0,000 0,08822657 0,10957677 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,08822657 0,10952109 ! neural tube closure GO:0001843 58 26 0,000 0,08822657 0,10946547 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,08822657 0,1094099 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,08822657 0,10935439 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,08822657 0,10929894 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,09146108 0,11324856 ! embryonic pattern specification GO:0009880 49 27 0,000 0,09146108 0,11319119 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,09146108 0,11313388 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,09146108 0,11307663 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,09146108 0,11301943 ! iron ion transport GO:0006826 65 27 0,000 0,09146108 0,11296229 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,09146108 0,11290521 ! superoxide metabolic process GO:0006801 41 27 0,000 0,09146108 0,11284819 ! tube lumen formation GO:0035148 59 27 0,000 0,09146108 0,11279123 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,09146108 0,11273432 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,09146108 0,11267747 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,09146108 0,11262067 ! response to toxin GO:0009636 49 27 0,000 0,09146108 0,11256394 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,09146108 0,11250726 ! leukocyte proliferation GO:0070661 59 27 0,000 0,09146108 0,11245064 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,09146108 0,11239407 ! neuron fate commitment GO:0048663 52 28 0,000 0,09468421 0,11629639 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,09468421 0,11623795 ! vesicle docking GO:0048278 55 28 0,000 0,09468421 0,11617957 ! circadian rhythm GO:0007623 56 28 0,000 0,09468421 0,11612125 ! dendrite development GO:0016358 67 28 0,000 0,09468421 0,11606298 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,09468421 0,11600478 ! fat cell differentiation GO:0045444 57 28 0,000 0,09468421 0,11594663 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,09468421 0,11588854 ! sperm motility GO:0030317 37 28 0,000 0,09468421 0,11583051 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,09468421 0,11577253 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,09468421 0,11571462 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,09468421 0,11565676 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,09468421 0,11559896 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,09468421 0,11554122 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,09468421 0,11548354 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,09468421 0,11542591 ! glutathione metabolic process GO:0006749 42 28 0,000 0,09468421 0,11536834 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,09468421 0,11531083 ! lipid oxidation GO:0034440 48 28 0,000 0,09468421 0,11525338 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,09468421 0,11519598 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,09468421 0,11513864 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,097896 0,11898503 ! translational initiation GO:0006413 66 29 0,000 0,097896 0,11892587 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,097896 0,11886676 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,097896 0,11880771 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,097896 0,11874872 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,097896 0,11868979 ! primary neural tube formation GO:0014020 61 29 0,000 0,097896 0,11863091 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,097896 0,1185721 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,097896 0,11851334 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,097896 0,11845464 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,097896 0,118396 ! synaptogenesis GO:0007416 46 29 0,000 0,097896 0,11833742 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,097896 0,11827889 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,097896 0,11822042 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,097896 0,11816201 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,10109648 0,12196479 ! phenol metabolic process GO:0018958 56 30 0,000 0,10109648 0,12190459 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,10109648 0,12184445 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,10109648 0,12178437 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,10109648 0,12172434 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,10109648 0,12166438 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,10109648 0,12160448 ! acute-phase response GO:0006953 50 30 0,000 0,10109648 0,12154463 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,10109648 0,12148485 ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,10109648 0,12142512 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,10109648 0,12136545 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,10109648 0,12130584 ! cell fate determination GO:0001709 64 30 0,000 0,10109648 0,12124629 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,10109648 0,1211868 ! phospholipid transport GO:0015914 65 30 0,000 0,10109648 0,12112736 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,10109648 0,12106799 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,10109648 0,12100867 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,10109648 0,12094941 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,10109648 0,12089021 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,10109648 0,12083106 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,10109648 0,12077198 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,10428569 0,12452099 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,10428569 0,12446016 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,10428569 0,12439939 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,10428569 0,12433868 ! regulation of innate immune response GO:0045088 57 31 0,000 0,10428569 0,12427802 ! ovulation cycle process GO:0022602 55 31 0,000 0,10428569 0,12421743 ! peptide transport GO:0015833 60 31 0,000 0,10428569 0,1241569 ! male gonad development GO:0008584 56 31 0,000 0,10428569 0,12409642 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,10428569 0,124036 ! detection of light stimulus GO:0009583 44 31 0,000 0,10428569 0,12397565 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,10428569 0,12391535 ! natural killer cell activation GO:0030101 50 31 0,000 0,10428569 0,1238551 ! ensheathment of neurons GO:0007272 64 31 0,000 0,10428569 0,12379492 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,10428569 0,1237348 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,10428569 0,12367473 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,10428569 0,12361473 ! eye morphogenesis GO:0048592 65 31 0,000 0,10428569 0,12355478 ! response to heat GO:0009408 54 31 0,000 0,10428569 0,12349489 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,10428569 0,12343505 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,10746369 0,127135 ! collagen metabolic process GO:0032963 49 32 0,000 0,10746369 0,12707347 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,10746369 0,12701199 ! spindle organization GO:0007051 50 32 0,000 0,10746369 0,12695057 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,10746369 0,12688921 ! metanephros development GO:0001656 81 32 0,000 0,10746369 0,12682791 ! mesoderm formation GO:0001707 73 32 0,000 0,10746369 0,12676667 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,10746369 0,12670549 ! ovulation cycle GO:0042698 57 32 0,000 0,10746369 0,12664437 ! peripheral nervous system development GO:0007422 68 32 0,000 0,10746369 0,12658331 ! BMP signaling pathway GO:0030509 71 32 0,000 0,10746369 0,12652231 ! hindbrain development GO:0030902 65 32 0,000 0,10746369 0,12646136 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,10746369 0,12640047 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,10746369 0,12633965 ! gene silencing GO:0016458 71 32 0,000 0,10746369 0,12627888 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,11063049 0,12993764 ! pigment biosynthetic process GO:0046148 73 33 0,000 0,11063049 0,1298752 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,11063049 0,12981282 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,11063049 0,1297505 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,11063049 0,12968824 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,11063049 0,12962604 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,11063049 0,1295639 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,11063049 0,12950181 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,11063049 0,12943979 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,11063049 0,12937783 ! glial cell differentiation GO:0010001 67 34 0,000 0,11378615 0,13300457 ! post-embryonic development GO:0009791 76 34 0,000 0,11378615 0,13294097 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,11378615 0,13287742 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,11378615 0,13281393 ! spliceosome assembly GO:0000245 75 34 0,000 0,11378615 0,13275051 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,11378615 0,13268714 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,11378615 0,13262384 ! formation of primary germ layer GO:0001704 76 34 0,000 0,11378615 0,13256059 ! cell fate specification GO:0001708 56 34 0,000 0,11378615 0,13249741 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,11378615 0,13243428 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,11378615 0,13237122 ! adult locomotory behavior GO:0008344 62 34 0,000 0,11378615 0,13230821 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,1169307 0,13589995 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,1169307 0,13583533 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,1169307 0,13577077 ! membrane docking GO:0022406 69 35 0,000 0,1169307 0,13570627 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,1169307 0,13564183 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,1169307 0,13557745 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,1169307 0,13551314 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,1169307 0,13544888 ! ceramide metabolic process GO:0006672 72 35 0,000 0,1169307 0,13538469 ! telencephalon development GO:0021537 81 35 0,000 0,1169307 0,13532056 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,1169307 0,13525648 ! placenta development GO:0001890 53 35 0,000 0,1169307 0,13519247 ! vesicle localization GO:0051648 70 35 0,000 0,1169307 0,13512852 ! regulation of muscle development GO:0048634 82 36 0,000 0,12006418 0,13868406 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,12006418 0,13861852 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,12006418 0,13855304 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,12006418 0,13848762 ! positive regulation of cell development GO:0010720 85 36 0,000 0,12006418 0,13842227 ! protein targeting to membrane GO:0006612 75 36 0,000 0,12006418 0,13835697 ! regulation of proteolysis GO:0030162 77 36 0,000 0,12006418 0,13829174 ! aerobic respiration GO:0009060 56 36 0,000 0,12006418 0,13822657 ! cytokine production GO:0001816 68 36 0,000 0,12006418 0,13816146 ! embryonic organ development GO:0048568 67 36 0,000 0,12006418 0,13809641 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,12006418 0,13803143 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,12006418 0,1379665 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,12318663 0,14148798 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,12318663 0,14142149 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,12318663 0,14135506 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,12318663 0,1412887 ! sister chromatid segregation GO:0000819 65 37 0,000 0,12318663 0,1412224 ! odontogenesis GO:0042476 74 37 0,000 0,12318663 0,14115616 ! tissue remodeling GO:0048771 78 37 0,000 0,12318663 0,14108998 ! female gonad development GO:0008585 71 37 0,000 0,12318663 0,14102386 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,12318663 0,14095781 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,12318663 0,14089182 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,12318663 0,14082589 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,12318663 0,14076002 ! meiosis I GO:0007127 74 38 0,000 0,12629808 0,14424788 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,12629808 0,14418047 ! organic anion transport GO:0015711 82 38 0,000 0,12629808 0,14411313 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,12629808 0,14404585 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,12629808 0,14397864 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,12629808 0,14391148 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,12629808 0,14384439 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,12629808 0,14377736 ! spermatid development GO:0007286 69 38 0,000 0,12629808 0,14371039 ! glycogen metabolic process GO:0005977 63 38 0,000 0,12629808 0,14364349 ! pigment metabolic process GO:0042440 87 38 0,000 0,12629808 0,14357665 ! neural tube formation GO:0001841 79 38 0,000 0,12629808 0,14350987 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,12939858 0,14696455 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,12939858 0,14689626 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,12939858 0,14682803 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,12939858 0,14675986 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,12939858 0,14669176 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,12939858 0,14662372 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,12939858 0,14655575 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,12939858 0,14648783 ! glucan metabolic process GO:0044042 64 39 0,000 0,12939858 0,14641998 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,13248817 0,14984658 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,13248817 0,14977723 ! learning GO:0007612 82 40 0,000 0,13248817 0,14970796 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,13248817 0,14963874 GO:0046660|female sex differentiation, ! mismatch repair GO:0006298 58 40 0,000 0,13248817 0,14956959 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,13248817 0,14950051 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,13248817 0,14943149 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,13248817 0,14936253 ! RNA export from nucleus GO:0006405 61 41 0,000 0,13556688 0,15276286 ! mRNA catabolic process GO:0006402 79 41 0,000 0,13556688 0,15269243 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,13556688 0,15262207 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,13556688 0,15255177 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,13556688 0,15248153 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,13556688 0,15241136 ! gliogenesis GO:0042063 91 41 0,000 0,13556688 0,15234126 ! feeding behavior GO:0007631 69 41 0,000 0,13556688 0,15227121 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,13556688 0,15220124 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,13556688 0,15213132 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,13556688 0,15206147 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,13556688 0,15199169 ! RNA modification GO:0009451 64 41 0,000 0,13556688 0,15192197 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,13863475 0,15528872 ! organic ether metabolic process GO:0018904 59 42 0,000 0,13863475 0,15521755 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,13863475 0,15514645 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,13863475 0,15507541 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,13863475 0,15500444 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,13863475 0,15493353 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,13863475 0,15486269 ! cytokinesis GO:0000910 84 42 0,000 0,13863475 0,15479191 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,13863475 0,15472119 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,14169182 0,15806078 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,14169182 0,15798864 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,14169182 0,15791657 ! regulation of tube size GO:0035150 76 43 0,000 0,14169182 0,15784456 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,14169182 0,15777261 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,14169182 0,15770073 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,14169182 0,15762892 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,14169182 0,15755717 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,14169182 0,15748549 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,14169182 0,15741388 ! ion transmembrane transport GO:0034220 79 43 0,000 0,14169182 0,15734232 ! neuron migration GO:0001764 85 43 0,000 0,14169182 0,15727084 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,14473812 0,16057912 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,14473812 0,16050623 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,14473812 0,16043341 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,14473812 0,16036065 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,14473812 0,16028796 ! striated muscle contraction GO:0006941 85 44 0,000 0,14473812 0,16021533 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,14473812 0,16014277 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,1477737 0,16342741 ! regulation of epithelial cell proliferation GO:0050678 122 45 0,000 0,1477737 0,16335346 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,1477737 0,16327958 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! biopolymer methylation GO:0043414 91 45 0,000 0,1477737 0,16320576 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,1477737 0,16313201 ! female gamete generation GO:0007292 71 45 0,000 0,1477737 0,16305833 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,1477737 0,16298472 ! developmental growth GO:0048589 88 45 0,000 0,1477737 0,16291117 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,15079859 0,16617093 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,15079859 0,16609601 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 0,000 0,15079859 0,16602116 ! glycolysis GO:0006096 71 46 0,000 0,15079859 0,16594637 ! leukocyte migration GO:0050900 75 46 0,000 0,15079859 0,16587166 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,15079859 0,16579701 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,15079859 0,16572242 ! cell growth GO:0016049 90 46 0,000 0,15079859 0,16564791 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,15079859 0,16557346 ! neural tube development GO:0021915 91 47 0,000 0,15381282 0,16880716 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,15381282 0,16873136 ! positive regulation of defense response GO:0031349 88 48 0,000 0,15681645 0,17194909 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,15681645 0,17187195 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,15681645 0,17179488 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,15681645 0,17171788 ! endosome transport GO:0016197 127 48 0,000 0,15681645 0,17164094 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,15681645 0,17156408 ! male sex differentiation GO:0046661 93 48 0,000 0,15681645 0,17148728 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,15681645 0,17141055 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,15681645 0,17133389 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,15681645 0,1712573 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,15681645 0,17118078 ! methylation GO:0032259 97 48 0,000 0,15681645 0,17110432 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,15980949 0,17429223 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,15980949 0,17421445 ! JNK cascade GO:0007254 106 49 0,000 0,15980949 0,17413675 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,15980949 0,17405911 ! protein homooligomerization GO:0051260 84 49 0,000 0,15980949 0,17398155 ! regulation of ion transport GO:0043269 86 50 0,000 0,162792 0,1771496 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,162792 0,17707072 ! endocrine system development GO:0035270 109 50 0,000 0,162792 0,17699192 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,162792 0,17691319 ! regulation of ossification GO:0030278 123 50 0,000 0,162792 0,17683453 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,162792 0,17675593 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,165764 0,17990291 ! peptide metabolic process GO:0006518 80 51 0,000 0,165764 0,17982302 ! response to temperature stimulus GO:0009266 84 51 0,000 0,165764 0,17974321 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,165764 0,17966346 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,16872553 0,18279223 ! Notch signaling pathway GO:0007219 111 52 0,000 0,16872553 0,1827112 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,16872553 0,18263025 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,16872553 0,18254937 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,16872553 0,18246856 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,16872553 0,18238782 ! excretion GO:0007588 87 52 0,000 0,16872553 0,18230715 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,16872553 0,18222656 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,16872553 0,18214603 ! amino acid activation GO:0043038 98 52 0,000 0,16872553 0,18206558 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,17167664 0,18516822 ! inner ear development GO:0048839 89 53 0,000 0,17167664 0,18508651 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,17167664 0,18500486 ! vesicle organization GO:0016050 127 53 0,000 0,17167664 0,18492329 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,17167664 0,18484179 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cartilage development GO:0051216 99 53 0,000 0,17167664 0,18476036 ! synapse organization GO:0050808 102 53 0,000 0,17167664 0,18467901 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,17461735 0,18775976 ! regulation of translational initiation GO:0006446 87 54 0,000 0,17461735 0,18767716 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,17461735 0,18759462 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,17461735 0,18751217 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,17461735 0,18742978 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,17461735 0,18734746 ! membrane fusion GO:0006944 122 54 0,000 0,17461735 0,18726522 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,17461735 0,18718305 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,17461735 0,18710095 ! regulation of cell shape GO:0008360 142 54 0,000 0,17461735 0,18701893 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,17461735 0,18693697 ! RNA catabolic process GO:0006401 103 55 0,000 0,1775477 0,18999081 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,1775477 0,18990763 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,1775477 0,18982452 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,1775477 0,18974148 ! cell recognition GO:0008037 98 55 0,000 0,1775477 0,18965852 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,1775477 0,18957562 ! cell maturation GO:0048469 107 55 0,000 0,1775477 0,1894928 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,1775477 0,18941006 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,1775477 0,18932738 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,18046773 0,19235718 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,18046773 0,19227329 ! glucose catabolic process GO:0006007 88 56 0,000 0,18046773 0,19218948 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,18046773 0,19210574 ! RNA elongation GO:0006354 90 56 0,000 0,18046773 0,19202207 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 0,000 0,18337748 0,19503316 ! chloride transport GO:0006821 102 57 0,000 0,18337748 0,19494829 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,18337748 0,19486349 ! muscle fiber development GO:0048747 131 57 0,000 0,18337748 0,19477877 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,18337748 0,19469412 ! regulation of actin filament length GO:0030832 118 58 0,000 0,18627697 0,19768664 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,18627697 0,1976008 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,18627697 0,19751504 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,18627697 0,19742935 ! gastrulation GO:0007369 122 58 0,000 0,18627697 0,19734373 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,18627697 0,19725819 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,18627697 0,19717272 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,19204536 0,20319048 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,19204536 0,20310252 ! adult behavior GO:0030534 104 60 0,000 0,19204536 0,20301463 ! positive regulation of secretion GO:0051047 110 61 0,000 0,19491432 0,20595835 ! regulation of cellular component size GO:0032535 125 61 0,000 0,19491432 0,2058693 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,19491432 0,20578033 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,19491432 0,20569144 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,19491432 0,20560263 ! camera-type eye development GO:0043010 126 61 0,000 0,19491432 0,20551389 ! proton transport GO:0015992 117 61 0,000 0,19491432 0,20542523 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,19491432 0,20533665 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,19777318 0,20825857 ! tRNA processing GO:0008033 102 62 0,000 0,19777318 0,20816884 ! mesoderm development GO:0007498 128 63 0,000 0,20062197 0,21107643 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,20062197 0,21098556 ! hydrogen transport GO:0006818 121 64 0,000 0,20346071 0,21387888 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,20346071 0,21378689 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,20628946 0,21666602 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,20628946 0,21657291 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,20628946 0,21647988 ! gonad development GO:0008406 115 66 0,000 0,20910824 0,21934368 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,21191709 0,22219462 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,21191709 0,22209929 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,21191709 0,22200405 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,21191709 0,2219089 ! secondary metabolic process GO:0019748 125 67 0,000 0,21191709 0,22181382 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,21471604 0,22464724 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,21471604 0,22455107 ! hexose catabolic process GO:0019320 113 68 0,000 0,21471604 0,22445498 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,21471604 0,22435898 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,21471604 0,22426306 ! regulation of lipase activity GO:0060191 137 68 0,000 0,21471604 0,22416722 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,21471604 0,22407146 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,21750513 0,22688516 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,21750513 0,22678832 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,21750513 0,22669157 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,21750513 0,2265949 ! developmental maturation GO:0021700 128 69 0,000 0,21750513 0,22649831 ! single fertilization GO:0007338 83 69 0,000 0,21750513 0,22640181 ! germ cell development GO:0007281 133 70 0,000 0,2202844 0,2291971 ! activation of immune response GO:0002253 120 70 0,000 0,2202844 0,22909952 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,2202844 0,22900204 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,22305387 0,23178247 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,22305387 0,23168393 ! appendage morphogenesis GO:0035107 150 72 0,000 0,22581358 0,23445073 GO:0035108|limb morphogenesis, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,22581358 0,23435113 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,22581358 0,23425162 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,22581358 0,23415219 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,22581358 0,23405285 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,22581358 0,23395359 ! appendage development GO:0048736 151 73 0,000 0,22856356 0,23670233 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,22856356 0,23660203 ! regulation of immune effector process GO:0002697 156 73 0,000 0,22856356 0,23650181 ! acute inflammatory response GO:0002526 118 74 0,000 0,23130386 0,23923595 ! amino acid transport GO:0006865 148 74 0,000 0,23130386 0,23913471 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,23130386 0,23903356 ! transition metal ion transport GO:0000041 143 75 0,000 0,2340345 0,24175318 ! reproductive structure development GO:0048608 131 75 0,000 0,2340345 0,241651 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,2340345 0,24154891 ! eye development GO:0001654 155 75 0,000 0,2340345 0,24144691 ! axon guidance GO:0007411 162 75 0,000 0,2340345 0,24134499 ! rhythmic process GO:0048511 142 75 0,000 0,2340345 0,24124315 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,23675551 0,24394505 ! learning or memory GO:0007611 161 76 0,000 0,23675551 0,2438422 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,23675551 0,24373945 ! regulation of blood pressure GO:0008217 134 76 0,000 0,23675551 0,24363678 ! amine catabolic process GO:0009310 136 77 0,000 0,23946693 0,24632325 ! neurotransmitter transport GO:0006836 142 77 0,000 0,23946693 0,24621958 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,23946693 0,246116 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,23946693 0,2460125 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,23946693 0,24590909 ! fertilization GO:0009566 99 78 0,000 0,2421688 0,24857915 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,2421688 0,24847475 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,24486115 0,25113173 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,24486115 0,25102635 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,24486115 0,25092105 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,24486115 0,25081584 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,24486115 0,25071072 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,247544 0,25335149 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,247544 0,25324539 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,247544 0,25313939 ! meiosis GO:0007126 143 81 0,000 0,2502174 0,25576616 GO:0051327|M phase of meiotic cell cycle, ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,2502174 0,25565919 ! meiotic cell cycle GO:0051321 144 82 0,000 0,25288138 0,25827308 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,25553597 0,26087521 ! exocytosis GO:0006887 153 83 0,000 0,25553597 0,26076624 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,25553597 0,26065736 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,25553597 0,26054857 ! inorganic anion transport GO:0015698 156 83 0,000 0,25553597 0,26043987 ! response to nutrient GO:0007584 135 84 0,000 0,2581812 0,26302613 ! regulation of ligase activity GO:0051340 147 84 0,000 0,2581812 0,26291649 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,2608171 0,26549007 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,2608171 0,2653795 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,26344371 0,26794046 ! regulation of lyase activity GO:0051339 169 86 0,000 0,26344371 0,26782896 ! positive regulation of cell activation GO:0050867 161 86 0,000 0,26344371 0,26771755 GO:0002696|positive regulation of leukocyte activation, ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,26606107 0,27026494 ! alcohol catabolic process GO:0046164 142 87 0,000 0,26606107 0,27015261 ! nucleosome assembly GO:0006334 126 87 0,000 0,26606107 0,27004038 ! cellular respiration GO:0045333 143 88 0,000 0,26866919 0,27257427 ! sensory perception of smell GO:0007608 117 88 0,000 0,26866919 0,27246112 ! chromatin assembly GO:0031497 128 88 0,000 0,26866919 0,27234806 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,26866919 0,2722351 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,27126812 0,27475457 ! cellular defense response GO:0006968 123 89 0,000 0,27126812 0,27464071 ! regulation of neurological system process GO:0031644 175 89 0,000 0,27126812 0,27452694 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,27385789 0,27703305 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,27385789 0,27691839 ! response to unfolded protein GO:0006986 139 90 0,000 0,27385789 0,27680382 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,27643853 0,27929666 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,27643853 0,2791812 ! bone development GO:0060348 206 92 0,000 0,27901007 0,28166181 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,27901007 0,28154547 ! regulation of cell adhesion GO:0030155 241 92 0,000 0,27901007 0,28142923 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,28157254 0,2838967 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,28157254 0,28377958 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,28157254 0,28366256 ! vitamin metabolic process GO:0006766 153 93 0,000 0,28157254 0,28354563 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,28412597 0,28599907 ! female pregnancy GO:0007565 166 94 0,000 0,28412597 0,28588128 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,28412597 0,28576359 ! regulation of defense response GO:0031347 171 95 0,000 0,2866704 0,28820403 ! nucleosome organization GO:0034728 143 95 0,000 0,2866704 0,28808548 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,2866704 0,28796702 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,2866704 0,28784866 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,2866704 0,2877304 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,2866704 0,28761224 ! sex differentiation GO:0007548 171 96 0,000 0,28920587 0,29003692 ! response to protein stimulus GO:0051789 158 96 0,000 0,28920587 0,2899179 ! regulation of T cell activation GO:0050863 175 96 0,000 0,28920587 0,28979899 ! interphase of mitotic cell cycle GO:0051329 224 98 0,000 0,29424999 0,29473257 ! forebrain development GO:0030900 210 98 0,000 0,29424999 0,29461178 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,29424999 0,29449108 ! positive regulation of immune response GO:0050778 175 100 0,000 0,29925861 0,29938116 ! hormone metabolic process GO:0042445 171 100 0,000 0,29925861 0,29925861