pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/549-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! insulin receptor signaling pathway GO:0008286 40 24 5,000 1,112E-09 2,559E-06 ! cellular response to insulin stimulus GO:0032869 52 34 5,000 1,071E-08 1,231E-05 ! regulation of lipid kinase activity GO:0043550 12 7 3,000 1,557E-08 1,193E-05 ! response to insulin stimulus GO:0032868 63 43 5,000 4,694E-08 2,699E-05 ! response to peptide hormone stimulus GO:0043434 84 57 5,000 2,652E-07 1,22E-04 ! nuclear migration GO:0007097 10 5 2,000 9,88E-07 3,787E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 9,88E-07 3,246E-04 GO:0031272|regulation of pseudopodium assembly, ! cellular response to hormone stimulus GO:0032870 109 74 5,000 1,271E-06 3,653E-04 ! regulation of DNA binding GO:0051101 119 77 5,000 1,608E-06 4,11E-04 ! macrophage differentiation GO:0030225 10 6 2,000 1,969E-06 4,529E-04 ! protein import into nucleus, translocation GO:0000060 36 22 3,000 3,084E-06 6,448E-04 ! maintenance of location GO:0051235 84 49 4,000 3,255E-06 6,238E-04 ! establishment of nucleus localization GO:0040023 13 7 2,000 3,434E-06 6,076E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 5,477E-06 8,997E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 5,477E-06 8,397E-04 ! regulation of binding GO:0051098 151 95 5,000 5,512E-06 7,924E-04 ! sequestering of metal ion GO:0051238 11 9 2,000 8,187E-06 1,108E-03 ! nucleus localization GO:0051647 15 9 2,000 8,187E-06 1,046E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 1,166E-05 1,411E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 1,166E-05 1,34E-03 ! filopodium assembly GO:0046847 19 11 2,000 1,597E-05 1,749E-03 ! microspike assembly GO:0030035 23 12 2,000 2,123E-05 2,219E-03 ! protein import into nucleus GO:0006606 118 74 4,000 2,509E-05 2,509E-03 ! nuclear import GO:0051170 121 75 4,000 2,678E-05 2,567E-03 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 2,000 2,75E-05 2,53E-03 ! maintenance of location in cell GO:0051651 69 38 3,000 2,939E-05 2,6E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 3,488E-05 2,971E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 3,613E-05 2,968E-03 ! protein localization in nucleus GO:0034504 133 80 4,000 3,663E-05 2,905E-03 ! positive regulation of DNA binding GO:0043388 57 41 3,000 3,989E-05 3,059E-03 ! positive regulation of binding GO:0051099 59 43 3,000 4,827E-05 3,581E-03 ! regulation of gene-specific transcription GO:0032583 69 43 3,000 4,827E-05 3,47E-03 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 4,907E-05 3,42E-03 ! leukocyte differentiation GO:0002521 143 90 4,000 6,455E-05 4,367E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 7,477E-05 4,913E-03 ! positive regulation of DNA replication GO:0045740 29 18 2,000 7,714E-05 4,928E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 7,714E-05 4,795E-03 ! response to lipopolysaccharide GO:0032496 26 19 2,000 9,13E-05 5,526E-03 ! protein import GO:0017038 156 99 4,000 1,016E-04 5,995E-03 ! aging GO:0007568 79 52 3,000 1,026E-04 5,897E-03 ! protein localization in organelle GO:0033365 161 100 4,000 1,066E-04 5,981E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 1,245E-04 6,816E-03 ! cell aging GO:0007569 32 21 2,000 1,245E-04 6,657E-03 ! regulation of lipid metabolic process GO:0019216 84 56 3,000 1,372E-04 7,17E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 1,436E-04 7,341E-03 ! protein tetramerization GO:0051262 39 22 2,000 1,436E-04 7,181E-03 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 1,646E-04 8,056E-03 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 1,646E-04 7,888E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 1,646E-04 7,727E-03 ! response to molecule of bacterial origin GO:0002237 30 23 2,000 1,646E-04 7,572E-03 ! myeloid cell differentiation GO:0030099 85 59 3,000 1,682E-04 7,584E-03 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 1,875E-04 8,293E-03 ! iron ion homeostasis GO:0055072 39 25 2,000 2,123E-04 9,215E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 2,154E-04 9,173E-03 ! protein maturation by protein folding GO:0022417 12 5 1,000 2,154E-04 9,006E-03 ! apoptotic cell clearance GO:0043277 13 5 1,000 2,154E-04 8,845E-03 ! lipoprotein particle clearance GO:0034381 9 5 1,000 2,154E-04 8,69E-03 ! response to protozoan GO:0001562 9 5 1,000 2,154E-04 8,54E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 2,154E-04 8,395E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 2,154E-04 8,255E-03 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 1,000 2,154E-04 8,12E-03 ! response to UV-C GO:0010225 6 5 1,000 2,154E-04 7,989E-03 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 1,000 2,154E-04 7,862E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 2,154E-04 7,739E-03 ! lymphocyte activation during immune response GO:0002285 9 5 1,000 2,154E-04 7,62E-03 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 1,000 2,154E-04 7,505E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 2,392E-04 8,212E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 2,994E-04 0,01012668 ! regulation of helicase activity GO:0051095 11 6 1,000 3,221E-04 0,01073509 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 1,000 3,221E-04 0,01058173 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 3,221E-04 0,0104327 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 3,221E-04 0,0102878 GO:0031958|corticosteroid receptor signaling pathway, ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 3,221E-04 0,01014687 ! ER overload response GO:0006983 7 6 1,000 3,221E-04 0,01000975 ! maintenance of protein location in nucleus GO:0051457 16 6 1,000 3,221E-04 9,876E-03 ! male sex determination GO:0030238 9 6 1,000 3,221E-04 9,746E-03 ! response to exogenous dsRNA GO:0043330 8 6 1,000 3,221E-04 9,62E-03 ! regulation of meiosis GO:0040020 10 6 1,000 3,221E-04 9,496E-03 GO:0051445|regulation of meiotic cell cycle, ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 3,221E-04 9,376E-03 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 3,328E-04 9,568E-03 ! mitochondrion organization GO:0007005 104 73 3,000 3,827E-04 0,0108655 ! maintenance of protein location in cell GO:0032507 60 31 2,000 4,067E-04 0,01140631 ! regulation of protein transport GO:0051223 114 76 3,000 4,463E-04 0,01236657 GO:0070201|regulation of establishment of protein localization, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 4,495E-04 0,01230774 ! T-helper 1 type immune response GO:0042088 11 7 1,000 4,495E-04 0,01216294 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 4,495E-04 0,01202151 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 1,000 4,495E-04 0,01188334 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 4,495E-04 0,0117483 ! protein heterooligomerization GO:0051291 10 7 1,000 4,495E-04 0,01161629 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 4,495E-04 0,01148722 ! fibrinolysis GO:0042730 9 7 1,000 4,495E-04 0,01136099 ! B cell lineage commitment GO:0002326 17 7 1,000 4,495E-04 0,0112375 ! regulation of interleukin-10 production GO:0032653 11 7 1,000 4,495E-04 0,01111667 ! T cell lineage commitment GO:0002360 12 7 1,000 4,495E-04 0,01099841 ! response to tumor cell GO:0002347 12 7 1,000 4,495E-04 0,01088263 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 1,000 4,495E-04 0,01076927 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 4,903E-04 0,01162514 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 5,359E-04 0,01257751 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 5,842E-04 0,0135718 ! maintenance of protein location GO:0045185 65 35 2,000 5,842E-04 0,01343608 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 5,975E-04 0,01360662 ! middle ear morphogenesis GO:0042474 9 8 1,000 5,975E-04 0,01347322 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 5,975E-04 0,01334241 ! polyamine biosynthetic process GO:0006596 9 8 1,000 5,975E-04 0,01321412 ! intestinal cholesterol absorption GO:0030299 13 8 1,000 5,975E-04 0,01308827 ! regulation of Notch signaling pathway GO:0008593 18 8 1,000 5,975E-04 0,01296479 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 5,975E-04 0,01284363 ! leukocyte activation during immune response GO:0002366 13 8 1,000 5,975E-04 0,01272471 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 1,000 5,975E-04 0,01260797 ! regulation of telomere maintenance GO:0032204 10 8 1,000 5,975E-04 0,01249335 ! regulation of embryonic development GO:0045995 16 8 1,000 5,975E-04 0,01238079 ! positive regulation of transcription factor activity GO:0051091 49 36 2,000 6,351E-04 0,01304299 GO:0090047|positive regulation of transcription regulator activity, ! regulation of protein localization GO:0032880 132 85 3,000 6,822E-04 0,01388495 ! cell cycle arrest GO:0007050 150 86 3,000 7,129E-04 0,01438344 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 7,659E-04 0,01531771 ! regulation of developmental growth GO:0048638 13 9 1,000 7,659E-04 0,01518566 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 7,659E-04 0,01505587 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 7,659E-04 0,01492827 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 15 9 1,000 7,659E-04 0,01480283 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 1,000 7,659E-04 0,01467947 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 7,659E-04 0,01455815 ! positive regulation of phagocytosis GO:0050766 11 9 1,000 7,659E-04 0,01443882 ! spleen development GO:0048536 15 9 1,000 7,659E-04 0,01432143 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 2,000 8,048E-04 0,01492718 ! T cell differentiation GO:0030217 65 40 2,000 8,671E-04 0,01595449 ! B cell differentiation GO:0030183 62 40 2,000 8,671E-04 0,01582786 ! cortical actin cytoskeleton organization GO:0030866 19 10 1,000 9,544E-04 0,01728518 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 9,544E-04 0,01715014 ! polyamine metabolic process GO:0006595 14 10 1,000 9,544E-04 0,01701719 ! response to X-ray GO:0010165 16 10 1,000 9,544E-04 0,01688629 ! lipid digestion GO:0044241 15 10 1,000 9,544E-04 0,01675739 ! alpha-beta T cell activation GO:0046631 16 10 1,000 9,544E-04 0,01663044 ! response to dsRNA GO:0043331 18 10 1,000 9,544E-04 0,0165054 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 9,544E-04 0,01638222 GO:0043470|regulation of carbohydrate catabolic process, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 9,544E-04 0,01626087 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 1,001E-03 0,01692427 ! cellular component disassembly GO:0022411 64 42 2,000 1,001E-03 0,01680074 ! activation of caspase activity GO:0006919 65 43 2,000 1,072E-03 0,01786958 ! regulation of cell projection organization GO:0031344 83 44 2,000 1,147E-03 0,01897509 ! cortical cytoskeleton organization GO:0030865 20 11 1,000 1,163E-03 0,01910629 ! virus-host interaction GO:0019048 17 11 1,000 1,163E-03 0,01897078 ! detection of mechanical stimulus GO:0050982 15 11 1,000 1,163E-03 0,01883719 ! focal adhesion formation GO:0048041 24 11 1,000 1,163E-03 0,01870546 ! regulation of intracellular pH GO:0051453 17 11 1,000 1,163E-03 0,01857556 ! regulation of phagocytosis GO:0050764 14 11 1,000 1,163E-03 0,01844745 ! regulation of interleukin-8 production GO:0032677 17 11 1,000 1,163E-03 0,0183211 ! positive regulation of cell cycle GO:0045787 77 45 2,000 1,225E-03 0,01915936 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 1,225E-03 0,0190299 ! response to UV GO:0009411 75 46 2,000 1,306E-03 0,02015293 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,391E-03 0,02133395 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 1,391E-03 0,02119267 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,391E-03 0,02105324 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,391E-03 0,02091564 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,391E-03 0,02077982 ! response to gamma radiation GO:0010332 20 12 1,000 1,391E-03 0,02064576 ! intestinal absorption GO:0050892 19 12 1,000 1,391E-03 0,02051342 ! positive regulation of caspase activity GO:0043280 72 48 2,000 1,478E-03 0,02164579 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 78 49 2,000 1,569E-03 0,02283452 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,639E-03 0,02371339 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 1,000 1,639E-03 0,02356518 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 1,639E-03 0,02341881 ! regulation of cellular pH GO:0030641 20 13 1,000 1,639E-03 0,02327425 ! positive regulation of cell migration GO:0030335 92 51 2,000 1,761E-03 0,0248507 ! establishment of organelle localization GO:0051656 85 52 2,000 1,863E-03 0,02612331 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,907E-03 0,02657856 ! inositol metabolic process GO:0006020 20 14 1,000 1,907E-03 0,02641845 ! activation of MAPKK activity GO:0000186 21 14 1,000 1,907E-03 0,02626025 ! cellular response to starvation GO:0009267 21 14 1,000 1,907E-03 0,02610394 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,907E-03 0,02594948 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,907E-03 0,02579684 ! intermediate filament-based process GO:0045103 24 14 1,000 1,907E-03 0,02564598 ! negative regulation of blood coagulation GO:0030195 19 14 1,000 1,907E-03 0,02549687 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 1,907E-03 0,02534949 ! cell projection assembly GO:0030031 76 53 2,000 1,968E-03 0,02601163 ! regulation of protein complex assembly GO:0043254 81 54 2,000 2,077E-03 0,02729238 ! lipid phosphorylation GO:0046834 23 15 1,000 2,193E-03 0,02866348 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 2,193E-03 0,02850154 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 2,193E-03 0,02834142 ! regulation of survival gene product expression GO:0045884 20 15 1,000 2,193E-03 0,02818309 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 2,193E-03 0,02802651 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 2,193E-03 0,02787167 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 2,305E-03 0,02913122 ! positive regulation of cell motion GO:0051272 99 56 2,000 2,305E-03 0,02897203 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 2,499E-03 0,03123881 ! protein amino acid acetylation GO:0006473 28 16 1,000 2,499E-03 0,03106995 ! cellular response to hydrogen peroxide GO:0070301 21 16 1,000 2,499E-03 0,03090291 GO:0042744|hydrogen peroxide catabolic process, ! NLS-bearing substrate import into nucleus GO:0006607 33 16 1,000 2,499E-03 0,03073766 ! protein export from nucleus GO:0006611 24 16 1,000 2,499E-03 0,03057416 ! DNA replication initiation GO:0006270 25 16 1,000 2,499E-03 0,03041239 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 2,499E-03 0,03025232 ! negative regulation of translation GO:0017148 22 16 1,000 2,499E-03 0,03009393 ! negative regulation of kinase activity GO:0033673 100 58 2,000 2,549E-03 0,03053201 ! activation of MAPK activity GO:0000187 84 59 2,000 2,676E-03 0,03189362 ! keratinization GO:0031424 17 17 1,000 2,824E-03 0,03347708 ! regulation of striated muscle contraction GO:0006942 20 17 1,000 2,824E-03 0,0333054 ! cell-substrate junction assembly GO:0007044 39 17 1,000 2,824E-03 0,03313547 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 2,824E-03 0,03296727 ! actin filament bundle formation GO:0051017 26 17 1,000 2,824E-03 0,03280077 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 2,824E-03 0,03263594 ! negative regulation of coagulation GO:0050819 23 17 1,000 2,824E-03 0,03247276 ! cell-matrix adhesion GO:0007160 114 61 2,000 2,943E-03 0,03367636 ! negative regulation of transferase activity GO:0051348 105 61 2,000 2,943E-03 0,03350965 ! negative regulation of cell growth GO:0030308 106 62 2,000 3,082E-03 0,03492258 ! organelle localization GO:0051640 96 62 2,000 3,082E-03 0,03475139 ! positive regulation of translation GO:0045727 28 18 1,000 3,167E-03 0,03553265 ! somitogenesis GO:0001756 24 18 1,000 3,167E-03 0,03536016 ! cellular response to nutrient levels GO:0031669 27 18 1,000 3,167E-03 0,03518934 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 3,167E-03 0,03502016 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 3,167E-03 0,0348526 ! regulation of transcription factor activity GO:0051090 97 63 2,000 3,226E-03 0,03532759 GO:0090046|regulation of transcription regulator activity, ! negative regulation of cell size GO:0045792 108 64 2,000 3,373E-03 0,03676571 ! regulation of caspase activity GO:0043281 97 65 2,000 3,524E-03 0,03823432 ! B cell activation GO:0042113 104 65 2,000 3,524E-03 0,03805482 ! protein oligomerization GO:0051259 100 65 2,000 3,524E-03 0,03787699 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 3,529E-03 0,03775095 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 3,529E-03 0,03757618 ! response to alkaloid GO:0043279 32 19 1,000 3,529E-03 0,03740301 ! digestive system process GO:0022600 30 19 1,000 3,529E-03 0,03723144 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 3,529E-03 0,03706143 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 3,529E-03 0,03689297 ! apoptotic nuclear changes GO:0030262 24 19 1,000 3,529E-03 0,03672604 ! response to starvation GO:0042594 30 19 1,000 3,529E-03 0,0365606 ! sex determination GO:0007530 29 19 1,000 3,529E-03 0,03639666 ! sarcomere organization GO:0045214 23 19 1,000 3,529E-03 0,03623417 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 1,000 3,529E-03 0,03607313 ! protein stabilization GO:0050821 26 19 1,000 3,529E-03 0,03591351 ! cell-substrate adhesion GO:0031589 121 66 2,000 3,68E-03 0,03728287 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 3,839E-03 0,03872915 ! protein amino acid O-linked glycosylation GO:0006493 29 20 1,000 3,909E-03 0,03926169 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 3,909E-03 0,03909099 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 4,307E-03 0,04288834 ! protein amino acid acylation GO:0043543 37 21 1,000 4,307E-03 0,04270348 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 4,307E-03 0,0425202 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 4,307E-03 0,04233849 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 4,307E-03 0,04215833 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 4,307E-03 0,04197969 ! lymphocyte differentiation GO:0030098 113 71 2,000 4,52E-03 0,04386034 ! regulation of peptidase activity GO:0052547 106 72 2,000 4,7E-03 0,04542251 ! response to hypoxia GO:0001666 132 72 2,000 4,7E-03 0,04523245 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 4,724E-03 0,04527039 ! macromolecular complex disassembly GO:0032984 38 22 1,000 4,724E-03 0,04508255 ! regulation of tumor necrosis factor production GO:0032680 28 22 1,000 4,724E-03 0,04489625 ! regulation of blood coagulation GO:0030193 34 22 1,000 4,724E-03 0,0447115 ! negative regulation of transport GO:0051051 116 73 2,000 4,885E-03 0,04604978 ! response to oxygen levels GO:0070482 137 74 2,000 5,075E-03 0,04763976 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 5,158E-03 0,04822596 ! negative regulation of DNA replication GO:0008156 35 23 1,000 5,158E-03 0,04803072 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 5,158E-03 0,04783704 ! hydrogen peroxide metabolic process GO:0042743 30 23 1,000 5,158E-03 0,04764493 ! interaction with host GO:0051701 37 23 1,000 5,158E-03 0,04745435 ! cellular response to oxidative stress GO:0034599 33 23 1,000 5,158E-03 0,04726529 ! negative regulation of growth GO:0045926 123 75 2,000 5,268E-03 0,04808493 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 5,61E-03 0,05099957 ! regulation of interferon-gamma production GO:0032649 30 24 1,000 5,61E-03 0,05079878 ! mitochondrial membrane organization GO:0007006 39 24 1,000 5,61E-03 0,05059957 ! negative regulation of cell development GO:0010721 56 24 1,000 5,61E-03 0,05040192 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 5,61E-03 0,0502058 ! regulation of chromosome organization GO:0033044 35 25 1,000 6,079E-03 0,0541954 ! positive regulation of nuclear division GO:0051785 39 25 1,000 6,079E-03 0,05398615 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 6,079E-03 0,05377851 ! T cell activation GO:0042110 134 79 2,000 6,088E-03 0,05364744 ! regulation of cell cycle process GO:0010564 122 81 2,000 6,524E-03 0,05727583 ! regulation of pH GO:0006885 36 26 1,000 6,566E-03 0,05742115 ! regulation of coagulation GO:0050818 39 26 1,000 6,566E-03 0,05720364 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 1,000 7,07E-03 0,06136057 ! myofibril assembly GO:0030239 36 27 1,000 7,07E-03 0,06112989 GO:0055002|striated muscle cell development, ! response to ionizing radiation GO:0010212 47 27 1,000 7,07E-03 0,06090094 ! negative regulation of protein transport GO:0051224 49 27 1,000 7,07E-03 0,06067369 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 7,453E-03 0,06372136 ! regulation of membrane potential GO:0042391 128 85 2,000 7,453E-03 0,06348536 ! cell junction assembly GO:0034329 56 28 1,000 7,591E-03 0,06442211 ! positive regulation of endocytosis GO:0045807 33 28 1,000 7,591E-03 0,06418526 ! cholesterol homeostasis GO:0042632 46 28 1,000 7,591E-03 0,06395015 GO:0055092|sterol homeostasis, ! positive regulation of catabolic process GO:0009896 40 28 1,000 7,591E-03 0,06371676 ! response to hydrogen peroxide GO:0042542 42 29 1,000 8,128E-03 0,06798147 ! muscle cell development GO:0055001 38 29 1,000 8,128E-03 0,06773516 ! regulation of neurogenesis GO:0050767 153 89 2,000 8,455E-03 0,07020505 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 8,682E-03 0,07183347 ! cholesterol transport GO:0030301 46 30 1,000 8,682E-03 0,07157601 GO:0015918|sterol transport, ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 8,682E-03 0,07132038 ! DNA damage checkpoint GO:0000077 53 31 1,000 9,253E-03 0,07573816 ! negative regulation of secretion GO:0051048 49 31 1,000 9,253E-03 0,07546958 ! mammary gland development GO:0030879 57 31 1,000 9,253E-03 0,07520291 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 9,253E-03 0,07493811 ! segmentation GO:0035282 41 31 1,000 9,253E-03 0,07467517 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 9,253E-03 0,07441406 ! response to mechanical stimulus GO:0009612 43 31 1,000 9,253E-03 0,07415478 ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 9,253E-03 0,0738973 ! peptidyl-amino acid modification GO:0018193 147 93 2,000 9,533E-03 0,07587005 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 9,84E-03 0,07804372 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 9,84E-03 0,07777552 ! regulation of protein stability GO:0031647 48 32 1,000 9,84E-03 0,07750917 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 9,84E-03 0,07724463 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,01039212 0,08129886 ! protein maturation GO:0051604 129 96 2,000 0,01039212 0,08102327 ! response to light stimulus GO:0009416 153 96 2,000 0,01039212 0,08074954 ! ear morphogenesis GO:0042471 42 33 1,000 0,01044352 0,08087576 ! actomyosin structure organization GO:0031032 43 33 1,000 0,01044352 0,08060436 ! cell junction organization GO:0034330 63 33 1,000 0,01044352 0,08033478 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 1,000 0,01044352 0,080067 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,01044352 0,079801 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 1,000 0,01044352 0,07953675 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,01044352 0,07927426 ! lipid homeostasis GO:0055088 55 33 1,000 0,01044352 0,07901349 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01044352 0,07875442 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,01106275 0,08315137 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,01106275 0,08288052 ! polyol metabolic process GO:0019751 44 34 1,000 0,01106275 0,08261142 ! regulation of translation GO:0006417 151 100 2,000 0,01160515 0,08638137 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,01169781 0,08679022 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,01234856 0,09132374 ! negative regulation of binding GO:0051100 58 36 1,000 0,01234856 0,09103103 ! regulation of protein secretion GO:0050708 51 37 1,000 0,01301483 0,09563611 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,01369646 0,10032441 ! phagocytosis GO:0006909 60 38 1,000 0,01369646 0,10000592 ! mesenchymal cell development GO:0014031 64 38 1,000 0,01369646 0,09968945 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 1,000 0,01369646 0,09937497 ! chromatin remodeling GO:0006338 68 39 1,000 0,01439331 0,10410257 ! response to calcium ion GO:0051592 58 40 1,000 0,01510522 0,10890909 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,01510522 0,10856875 ! double-strand break repair GO:0006302 67 40 1,000 0,01510522 0,10823053 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,01510522 0,10789441 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,01510522 0,10756037 ! glucose transport GO:0015758 52 41 1,000 0,01583203 0,11238786 ! mitochondrial transport GO:0006839 60 42 1,000 0,01657359 0,11729004 ! hexose transport GO:0008645 54 42 1,000 0,01657359 0,11693026 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,01657359 0,11657267 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 1,000 0,01657359 0,11621727 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,01657359 0,11586403 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,01732976 0,12078318 ! regulation of action potential GO:0001508 71 44 1,000 0,01810038 0,12577303 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,01810038 0,12539419 ! cell redox homeostasis GO:0045454 63 46 1,000 0,01968438 0,13595819 ! histone modification GO:0016570 68 46 1,000 0,01968438 0,13555113 ! covalent chromatin modification GO:0016569 75 47 1,000 0,02049747 0,1407289 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,02049747 0,14031006 ! regulation of muscle contraction GO:0006937 69 48 1,000 0,02132442 0,1455376 ! heart morphogenesis GO:0003007 65 48 1,000 0,02132442 0,14510702 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,02132442 0,14467898 GO:0019724|B cell mediated immunity, ! regulation of endocytosis GO:0030100 63 48 1,000 0,02132442 0,14425345 ! nuclear export GO:0051168 69 48 1,000 0,02132442 0,14383042 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,02132442 0,14340986 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,02216509 0,14862892 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,02216509 0,14819685 ! ear development GO:0043583 72 50 1,000 0,02301934 0,15346228 ! lipid modification GO:0030258 73 50 1,000 0,02301934 0,15301875 ! positive regulation of growth GO:0045927 67 50 1,000 0,02301934 0,15257777 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,02301934 0,15213933 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02323635 0,15313351 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02323635 0,15269599 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02323635 0,15226095 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02323635 0,1518284 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02323635 0,15139829 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02323635 0,15097061 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02323635 0,15054534 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02323635 0,15012246 ! sleep GO:0030431 11 5 0,000 0,02323635 0,14970195 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02323635 0,14928379 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02323635 0,14886795 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02323635 0,14845443 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02323635 0,1480432 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02323635 0,14763424 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02323635 0,14722753 ! tongue development GO:0043586 6 5 0,000 0,02323635 0,14682306 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02323635 0,14642081 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02323635 0,14602075 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02323635 0,14562288 ! cobalt ion transport GO:0006824 9 5 0,000 0,02323635 0,14522716 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02323635 0,14483359 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02323635 0,14444215 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02323635 0,14405282 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02323635 0,14366558 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02323635 0,14328042 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02323635 0,14289731 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02323635 0,14251625 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02323635 0,14213722 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02323635 0,1417602 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02323635 0,14138517 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02323635 0,14101212 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02323635 0,14064104 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02323635 0,1402719 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02323635 0,1399047 ! malate metabolic process GO:0006108 7 5 0,000 0,02323635 0,13953941 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02323635 0,13917603 ! behavioral response to pain GO:0048266 7 5 0,000 0,02323635 0,13881453 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02323635 0,13845491 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02323635 0,13809715 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02323635 0,13774122 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02323635 0,13738713 ! mating behavior GO:0007617 6 5 0,000 0,02323635 0,13703486 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02323635 0,13668439 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02323635 0,1363357 ! rhythmic behavior GO:0007622 12 5 0,000 0,02323635 0,13598879 ! copulation GO:0007620 7 5 0,000 0,02323635 0,13564364 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02323635 0,13530024 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02323635 0,13495857 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02323635 0,13461863 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02323635 0,13428039 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02323635 0,13394385 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02323635 0,13360899 ! lymph vessel development GO:0001945 7 5 0,000 0,02323635 0,1332758 ! endochondral ossification GO:0001958 12 5 0,000 0,02323635 0,13294427 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02323635 0,13261438 ! parathyroid gland development GO:0060017 8 5 0,000 0,02323635 0,13228613 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02323635 0,13195949 ! anagen GO:0042640 6 5 0,000 0,02323635 0,13163447 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02323635 0,13131104 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02323635 0,1309892 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02323635 0,13066894 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02323635 0,13035023 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02323635 0,13003308 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02323635 0,12971746 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02323635 0,12940338 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02323635 0,12909081 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02323635 0,12877975 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02323635 0,12847018 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02323635 0,1281621 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02323635 0,12785549 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02323635 0,12755035 ! ovulation GO:0030728 6 5 0,000 0,02323635 0,12724666 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02323635 0,12694441 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02323635 0,12664359 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,02323635 0,1263442 ! response to pH GO:0009268 9 5 0,000 0,02323635 0,12604622 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02323635 0,12574964 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02323635 0,12545445 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02323635 0,12516064 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02323635 0,12486821 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02323635 0,12457714 ! polyol catabolic process GO:0046174 7 5 0,000 0,02323635 0,12428743 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02323635 0,12399906 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02323635 0,12371203 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02323635 0,12342632 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02323635 0,12314192 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02323635 0,12285884 ! urea metabolic process GO:0019627 6 5 0,000 0,02323635 0,12257705 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02323635 0,12229656 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02323635 0,12201734 ! neutrophil activation GO:0042119 5 5 0,000 0,02323635 0,1217394 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02323635 0,12146272 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02323635 0,12118729 ! response to food GO:0032094 5 5 0,000 0,02323635 0,12091311 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02323635 0,12064017 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02323635 0,12036846 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02323635 0,12009797 ! forebrain neuron development GO:0021884 7 5 0,000 0,02323635 0,11982869 ! melanosome organization GO:0032438 7 5 0,000 0,02323635 0,11956062 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02323635 0,11929374 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02323635 0,11902805 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02323635 0,11876354 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02323635 0,11850021 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02323635 0,11823804 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02323635 0,11797703 ! nucleoside transport GO:0015858 6 5 0,000 0,02323635 0,11771717 ! nucleoside salvage GO:0043174 7 5 0,000 0,02323635 0,11745845 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02323635 0,11720087 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02323635 0,11694441 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02323635 0,11668907 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02323635 0,11643485 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02323635 0,11618173 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02323635 0,11592971 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02323635 0,11567878 ! depyrimidination GO:0045008 8 5 0,000 0,02323635 0,11542893 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02323635 0,11518016 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02323635 0,11493246 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02323635 0,11468583 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02323635 0,11444025 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02323635 0,11419572 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02323635 0,11395223 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02323635 0,11370978 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02323635 0,11346835 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02323635 0,11322796 ! monocyte differentiation GO:0030224 8 5 0,000 0,02323635 0,11298857 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02323635 0,1127502 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02323635 0,11251283 ! centrosome duplication GO:0051298 5 5 0,000 0,02323635 0,11227646 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02323635 0,11204108 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02323635 0,11180668 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02323635 0,11157327 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02323635 0,11134082 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02323635 0,11110935 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02323635 0,11087883 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02323635 0,11064927 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02323635 0,11042065 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02323635 0,11019298 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02323635 0,10996625 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02323635 0,10974044 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02323635 0,10951556 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02323635 0,10929161 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02323635 0,10906856 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02323635 0,10884643 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02323635 0,10862519 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02323635 0,10840486 ! neural tube patterning GO:0021532 6 5 0,000 0,02323635 0,10818542 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02323635 0,10796686 ! histone demethylation GO:0016577 9 5 0,000 0,02323635 0,10774918 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02323635 0,10753238 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02323635 0,10731646 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02323635 0,10710139 ! enteric nervous system development GO:0048484 8 5 0,000 0,02323635 0,10688719 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02323635 0,10667384 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02323635 0,10646135 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02323635 0,10624969 ! transcription termination GO:0006353 8 5 0,000 0,02323635 0,10603888 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02323635 0,1058289 ! plasminogen activation GO:0031639 5 5 0,000 0,02323635 0,10561975 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02323635 0,10541143 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02323635 0,10520393 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02323635 0,10499724 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02323635 0,10479136 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02323635 0,10458629 ! apical protein localization GO:0045176 6 5 0,000 0,02323635 0,10438202 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02323635 0,10417855 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02323635 0,10397587 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02323635 0,10377397 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02323635 0,10357286 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02323635 0,10337252 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02323635 0,10317296 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02323635 0,10297417 ! glial cell migration GO:0008347 10 5 0,000 0,02323635 0,10277614 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02323635 0,10257888 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02323635 0,10238237 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02323635 0,10218661 GO:0007439|ectodermal gut development, ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02323635 0,10199159 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02323635 0,10179732 ! neural plate development GO:0001840 6 5 0,000 0,02323635 0,10160379 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02323635 0,101411 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02323635 0,10121893 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02323635 0,10102759 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02323635 0,10083697 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02323635 0,10064707 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02323635 0,10045789 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02323635 0,10026941 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02323635 0,10008164 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02323635 0,09989457 ! spindle assembly GO:0051225 5 5 0,000 0,02323635 0,0997082 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02323635 0,09952252 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02323635 0,09933754 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02323635 0,09915324 ! organ regeneration GO:0031100 7 5 0,000 0,02323635 0,09896962 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02323635 0,09878668 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02323635 0,09860442 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02323635 0,09842283 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02323635 0,0982419 GO:0055081|anion homeostasis, ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,02388702 0,10080762 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,024768 0,10433405 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,02566212 0,10790288 ! kidney development GO:0001822 90 53 1,000 0,02566212 0,10770598 ! regulation of mitosis GO:0007088 84 54 1,000 0,02656926 0,11131018 GO:0051783|regulation of nuclear division, ! DNA catabolic process GO:0006308 67 54 1,000 0,02656926 0,1111078 ! detection of external stimulus GO:0009581 66 54 1,000 0,02656926 0,11090615 ! tRNA transcription GO:0009304 11 6 0,000 0,0278192 0,11591335 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,0278192 0,11570374 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,0278192 0,11549489 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,0278192 0,11528679 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,0278192 0,11507944 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,0278192 0,11487284 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,0278192 0,11466697 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,0278192 0,11446184 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,0278192 0,11425745 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,0278192 0,11405378 ! prostate gland development GO:0030850 9 6 0,000 0,0278192 0,11385084 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,0278192 0,11364861 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,0278192 0,11344711 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,0278192 0,11324632 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,0278192 0,11304624 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,0278192 0,11284686 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,0278192 0,11264819 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,0278192 0,11245021 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,0278192 0,11225293 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,0278192 0,11205634 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,0278192 0,11186044 ! neuron adhesion GO:0007158 9 6 0,000 0,0278192 0,11166522 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,0278192 0,11147068 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,0278192 0,11127682 ! signal peptide processing GO:0006465 8 6 0,000 0,0278192 0,11108363 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,0278192 0,11089111 ! mRNA stabilization GO:0048255 15 6 0,000 0,0278192 0,11069926 GO:0043489|RNA stabilization, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,0278192 0,11050807 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,0278192 0,11031753 ! opsonization GO:0008228 8 6 0,000 0,0278192 0,11012766 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,0278192 0,10993844 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,0278192 0,10974986 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,0278192 0,10956193 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,0278192 0,10937465 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,0278192 0,109188 ! photoreceptor cell development GO:0042461 10 6 0,000 0,0278192 0,10900199 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,0278192 0,10881662 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,0278192 0,10863187 ! mechanosensory behavior GO:0007638 8 6 0,000 0,0278192 0,10844775 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,0278192 0,10826425 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,0278192 0,10808137 ! response to interferon-gamma GO:0034341 12 6 0,000 0,0278192 0,10789911 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,0278192 0,10771746 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,0278192 0,10753642 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,0278192 0,10735599 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,0278192 0,10717616 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,0278192 0,10699694 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,0278192 0,10681831 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,0278192 0,10664028 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,0278192 0,10646285 ! thymic T cell selection GO:0045061 12 6 0,000 0,0278192 0,106286 ! protein lipoylation GO:0009249 10 6 0,000 0,0278192 0,10610973 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,0278192 0,10593406 ! pigment granule organization GO:0048753 11 6 0,000 0,0278192 0,10575896 ! drug transport GO:0015893 6 6 0,000 0,0278192 0,10558444 ! cysteine metabolic process GO:0006534 7 6 0,000 0,0278192 0,10541049 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,0278192 0,10523712 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,0278192 0,10506432 ! histidine metabolic process GO:0006547 6 6 0,000 0,0278192 0,10489208 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,0278192 0,10472041 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,0278192 0,1045493 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,0278192 0,10437874 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,0278192 0,10420875 ! adenohypophysis development GO:0021984 10 6 0,000 0,0278192 0,1040393 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,0278192 0,10387041 ! hyperosmotic response GO:0006972 8 6 0,000 0,0278192 0,10370206 ! microtubule nucleation GO:0007020 10 6 0,000 0,0278192 0,10353426 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,0278192 0,103367 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,0278192 0,10320027 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,0278192 0,10303409 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,0278192 0,10286844 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,0278192 0,10270332 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,0278192 0,10253873 ! response to dietary excess GO:0002021 7 6 0,000 0,0278192 0,10237467 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,0278192 0,10221113 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,0278192 0,10204812 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,0278192 0,10188562 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,0278192 0,10172364 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,0278192 0,10156217 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,0278192 0,10140122 ! neuron apoptosis GO:0051402 8 6 0,000 0,0278192 0,10124078 ! organic alcohol transport GO:0015850 9 6 0,000 0,0278192 0,10108084 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,0278192 0,1009214 ! T cell mediated immunity GO:0002456 12 6 0,000 0,0278192 0,10076247 ! carnitine transport GO:0015879 8 6 0,000 0,0278192 0,10060404 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,0278192 0,10044611 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,0278192 0,10028867 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,0278192 0,10013172 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,0278192 0,09997527 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,0278192 0,0998193 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,0278192 0,09966382 ! parturition GO:0007567 12 6 0,000 0,0278192 0,09950882 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,0278192 0,0993543 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,0278192 0,09920026 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,0278192 0,0990467 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,0278192 0,09889362 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,0278192 0,098741 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,0278192 0,09858886 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,0278192 0,09843718 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,0278192 0,09828598 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,0278192 0,09813523 ! astrocyte development GO:0014002 14 6 0,000 0,0278192 0,09798495 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,0278192 0,09783512 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,0278192 0,09768576 ! interaction with symbiont GO:0051702 8 6 0,000 0,0278192 0,09753684 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,0278192 0,09738839 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,0278192 0,09724038 ! eating behavior GO:0042755 6 6 0,000 0,0278192 0,09709282 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,0278192 0,09694571 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,0278192 0,09679905 ! response to copper ion GO:0046688 9 6 0,000 0,0278192 0,09665282 ! DNA topological change GO:0006265 8 6 0,000 0,0278192 0,09650704 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,0278192 0,0963617 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,0278192 0,0962168 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,0278192 0,09607233 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,0278192 0,09592829 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,0278192 0,09578469 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,0278192 0,09564151 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,0278192 0,09549876 ! gas homeostasis GO:0033483 11 6 0,000 0,0278192 0,09535644 ! hair follicle maturation GO:0048820 7 6 0,000 0,0278192 0,09521454 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,0278192 0,09507306 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,0278192 0,094932 ! Schwann cell development GO:0014044 14 6 0,000 0,0278192 0,09479136 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,0278192 0,09465114 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,0278192 0,09451133 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,0278192 0,09437193 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,0278192 0,09423295 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,0278192 0,09409437 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,0278192 0,0939562 ! histone ubiquitination GO:0016574 7 6 0,000 0,0278192 0,09381843 ! G2 phase GO:0051319 13 6 0,000 0,0278192 0,09368107 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,0278192 0,09354411 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,0278192 0,09340755 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,0278192 0,09327138 ! membrane to membrane docking GO:0022614 12 6 0,000 0,0278192 0,09313562 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,0278192 0,09300025 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,0278192 0,09286527 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,0278192 0,09273068 ! receptor internalization GO:0031623 9 6 0,000 0,0278192 0,09259648 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,0278192 0,09246267 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,0278192 0,09232925 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,0278192 0,09219621 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,0278192 0,09206355 ! protein deubiquitination GO:0016579 8 6 0,000 0,0278192 0,09193128 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,0278192 0,09179938 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,0278192 0,09166787 ! axonal fasciculation GO:0007413 9 6 0,000 0,0278192 0,09153672 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,0278192 0,09140596 ! thiamin metabolic process GO:0006772 6 6 0,000 0,0278192 0,09127556 ! midbrain development GO:0030901 6 6 0,000 0,0278192 0,09114554 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,0278192 0,09101589 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,0278192 0,09088661 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,0278192 0,09075769 ! progesterone metabolic process GO:0042448 8 6 0,000 0,0278192 0,09062914 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,0278192 0,09050095 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,0278192 0,09037312 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,0278192 0,09024566 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,0278192 0,09011855 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,0278192 0,0899918 ! adult feeding behavior GO:0008343 6 6 0,000 0,0278192 0,08986541 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,0278192 0,08973937 ! blastocyst growth GO:0001832 15 6 0,000 0,0278192 0,08961368 ! pigment granule transport GO:0051904 12 6 0,000 0,0278192 0,08948835 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,0278192 0,08936337 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,0278192 0,08923873 ! catecholamine transport GO:0051937 7 6 0,000 0,0278192 0,08911444 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,0278192 0,0889905 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,0278192 0,0888669 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,0278192 0,08874365 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,0278192 0,08862073 ! protein prenylation GO:0018342 10 6 0,000 0,0278192 0,08849816 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,0278192 0,08837593 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,0278192 0,08825403 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,0278192 0,08813247 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,0278192 0,08801124 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,0278192 0,08789034 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 0,02936735 0,0926542 ! carbohydrate transport GO:0008643 74 57 1,000 0,02936735 0,09252727 ! viral reproductive process GO:0022415 87 58 1,000 0,03032516 0,09541432 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,03032516 0,09528397 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,03032516 0,09515398 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,0312953 0,09806428 ! lung development GO:0030324 94 59 1,000 0,0312953 0,09793086 ! actin filament organization GO:0007015 95 59 1,000 0,0312953 0,0977978 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,03227763 0,10073072 ! regulation of heart contraction GO:0008016 91 60 1,000 0,03227763 0,10059423 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,03227763 0,10045811 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,03227763 0,10032235 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,03238082 0,10050727 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03238082 0,10037182 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03238082 0,10023673 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03238082 0,100102 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03238082 0,09996764 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03238082 0,09983363 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03238082 0,09969999 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03238082 0,0995667 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03238082 0,09943376 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03238082 0,09930119 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03238082 0,09916896 ! reproductive behavior GO:0019098 12 7 0,000 0,03238082 0,09903709 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03238082 0,09890556 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03238082 0,09877439 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,03238082 0,09864356 ! oligopeptide transport GO:0006857 11 7 0,000 0,03238082 0,09851308 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03238082 0,09838295 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03238082 0,09825315 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03238082 0,0981237 ! RNA methylation GO:0001510 11 7 0,000 0,03238082 0,09799459 ! pericardium development GO:0060039 8 7 0,000 0,03238082 0,09786582 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03238082 0,09773739 ! fibril organization GO:0043206 13 7 0,000 0,03238082 0,09760929 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03238082 0,09748153 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03238082 0,0973541 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03238082 0,09722701 ! lipoprotein transport GO:0042953 9 7 0,000 0,03238082 0,09710025 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03238082 0,09697382 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03238082 0,09684771 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03238082 0,09672193 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03238082 0,09659648 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03238082 0,09647136 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03238082 0,09634656 ! chemosensory behavior GO:0007635 9 7 0,000 0,03238082 0,09622208 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03238082 0,09609792 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03238082 0,09597408 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03238082 0,09585057 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03238082 0,09572736 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03238082 0,09560448 ! reflex GO:0060004 12 7 0,000 0,03238082 0,09548191 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03238082 0,09535965 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03238082 0,09523771 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03238082 0,09511608 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03238082 0,09499476 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03238082 0,09487375 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03238082 0,09475304 ! spinal cord patterning GO:0021511 7 7 0,000 0,03238082 0,09463264 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,03238082 0,09451255 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03238082 0,09439276 ! adrenal gland development GO:0030325 17 7 0,000 0,03238082 0,09427328 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03238082 0,0941541 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03238082 0,09403521 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03238082 0,09391663 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03238082 0,09379835 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03238082 0,09368036 ! endosome organization GO:0007032 10 7 0,000 0,03238082 0,09356268 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03238082 0,09344528 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03238082 0,09332818 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03238082 0,09321138 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03238082 0,09309486 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03238082 0,09297864 ! galactose metabolic process GO:0006012 10 7 0,000 0,03238082 0,09286271 ! vesicle fusion GO:0006906 15 7 0,000 0,03238082 0,09274706 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03238082 0,0926317 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03238082 0,09251663 ! organ growth GO:0035265 11 7 0,000 0,03238082 0,09240185 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03238082 0,09228735 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03238082 0,09217313 ! retinol metabolic process GO:0042572 9 7 0,000 0,03238082 0,0920592 ! behavioral fear response GO:0001662 13 7 0,000 0,03238082 0,09194554 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03238082 0,09183217 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03238082 0,09171908 ! rRNA modification GO:0000154 12 7 0,000 0,03238082 0,09160626 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03238082 0,09149372 ! response to UV-B GO:0010224 11 7 0,000 0,03238082 0,09138146 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03238082 0,09126947 ! intermediate filament organization GO:0045109 11 7 0,000 0,03238082 0,09115776 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03238082 0,09104632 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03238082 0,09093515 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,03238082 0,09082426 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03238082 0,09071363 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03238082 0,09060327 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03238082 0,09049318 ! response to tropane GO:0014073 13 7 0,000 0,03238082 0,09038336 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03238082 0,09027381 ! melanosome localization GO:0032400 10 7 0,000 0,03238082 0,09016452 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03238082 0,09005549 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03238082 0,08994673 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03238082 0,08983823 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03238082 0,08972999 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03238082 0,08962201 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03238082 0,08951429 ! mast cell activation GO:0045576 9 7 0,000 0,03238082 0,08940683 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03238082 0,08929963 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03238082 0,08919268 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03238082 0,08908599 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,03238082 0,08897956 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03238082 0,08887338 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03238082 0,08876745 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03238082 0,08866177 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03238082 0,08855635 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03238082 0,08845118 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03238082 0,08834625 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03238082 0,08824158 ! neuroblast proliferation GO:0007405 13 7 0,000 0,03238082 0,08813715 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03238082 0,08803297 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,03238082 0,08792903 ! diuresis GO:0030146 12 7 0,000 0,03238082 0,08782534 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03238082 0,0877219 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,03238082 0,08761869 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03238082 0,08751573 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03238082 0,08741302 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03238082 0,08731054 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03238082 0,0872083 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03238082 0,0871063 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03238082 0,08700454 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03238082 0,08690302 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03238082 0,08680174 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03238082 0,08670069 ! lymph node development GO:0048535 9 7 0,000 0,03238082 0,08659987 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03238082 0,08649929 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03238082 0,08639894 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03238082 0,08629883 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03238082 0,08619895 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03238082 0,08609929 ! ATP catabolic process GO:0006200 10 7 0,000 0,03238082 0,08599987 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03238082 0,08590068 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03238082 0,08580172 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03238082 0,08570298 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03238082 0,08560447 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03238082 0,08550619 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03238082 0,08540813 ! muscle adaptation GO:0043500 12 7 0,000 0,03238082 0,0853103 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03238082 0,08521269 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03238082 0,0851153 ! retina homeostasis GO:0001895 9 7 0,000 0,03238082 0,08501814 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03238082 0,0849212 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03238082 0,08482448 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03238082 0,08472797 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03238082 0,08463169 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03238082 0,08453563 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03238082 0,08443978 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03238082 0,08434416 ! lipoprotein metabolic process GO:0042157 89 61 1,000 0,03327202 0,08656747 ! urogenital system development GO:0001655 101 61 1,000 0,03327202 0,08646965 ! extracellular matrix organization GO:0030198 103 61 1,000 0,03327202 0,08637206 ! respiratory tube development GO:0030323 99 62 1,000 0,03427834 0,08888409 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,03427834 0,088784 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,03529647 0,09131819 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,03529647 0,09121559 ! viral reproduction GO:0016032 92 63 1,000 0,03529647 0,09111322 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,03632626 0,09366637 ! respiratory system development GO:0060541 100 64 1,000 0,03632626 0,09356148 ! adaptive immune response GO:0002250 94 64 1,000 0,03632626 0,09345682 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0369213 0,09488154 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0369213 0,09477565 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,0369213 0,09466999 ! axon extension GO:0048675 11 8 0,000 0,0369213 0,09456456 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,0369213 0,09445938 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0369213 0,09435442 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,0369213 0,0942497 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,0369213 0,09414521 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0369213 0,09404095 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,0369213 0,09393692 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,0369213 0,09383313 ! phosphate transport GO:0006817 10 8 0,000 0,0369213 0,09372956 ! N-glycan processing GO:0006491 12 8 0,000 0,0369213 0,09362622 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0369213 0,0935231 ! UTP metabolic process GO:0046051 8 8 0,000 0,0369213 0,09342022 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0369213 0,09331756 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0369213 0,09321512 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,0369213 0,09311292 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0369213 0,09301093 ! succinate metabolic process GO:0006105 14 8 0,000 0,0369213 0,09290917 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,0369213 0,09280763 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,0369213 0,09270631 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0369213 0,09260521 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,0369213 0,09250433 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0369213 0,09240368 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,0369213 0,09230324 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0369213 0,09220302 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0369213 0,09210301 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0369213 0,09200323 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0369213 0,09190366 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0369213 0,0918043 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0369213 0,09170516 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0369213 0,09160623 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,0369213 0,09150752 ! astrocyte differentiation GO:0048708 16 8 0,000 0,0369213 0,09140902 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0369213 0,09131073 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0369213 0,09121265 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0369213 0,09111478 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,0369213 0,09101713 GO:0006559|L-phenylalanine catabolic process, ! melanin metabolic process GO:0006582 12 8 0,000 0,0369213 0,09091968 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0369213 0,09082244 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0369213 0,0907254 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,0369213 0,09062858 ! macrophage activation GO:0042116 12 8 0,000 0,0369213 0,09053196 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0369213 0,09043555 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,0369213 0,09033934 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,0369213 0,09024334 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0369213 0,09014754 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,0369213 0,09005194 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,0369213 0,08995655 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0369213 0,08986135 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0369213 0,08976636 ! ruffle organization GO:0031529 11 8 0,000 0,0369213 0,08967157 ! osteoblast development GO:0002076 13 8 0,000 0,0369213 0,08957698 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0369213 0,08948259 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0369213 0,0893884 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,0369213 0,0892944 GO:0007351|tripartite regional subdivision, ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,0369213 0,08920061 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,0369213 0,08910701 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0369213 0,0890136 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0369213 0,0889204 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,0369213 0,08882738 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,0369213 0,08873457 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0369213 0,08864194 ! segment specification GO:0007379 10 8 0,000 0,0369213 0,08854951 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,0369213 0,08845727 ! cellular extravasation GO:0045123 11 8 0,000 0,0369213 0,08836522 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0369213 0,08827337 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0369213 0,0881817 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0369213 0,08809023 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,0369213 0,08799894 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0369213 0,08790785 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0369213 0,08781694 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,0369213 0,08772622 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,0369213 0,08763568 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0369213 0,08754534 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0369213 0,08745518 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0369213 0,0873652 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0369213 0,08727541 ! icosanoid secretion GO:0032309 12 8 0,000 0,0369213 0,08718581 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,0369213 0,08709639 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,0369213 0,08700715 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,0369213 0,08691809 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,0369213 0,08682922 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0369213 0,08674053 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0369213 0,08665202 ! sterol catabolic process GO:0016127 9 8 0,000 0,0369213 0,08656369 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0369213 0,08647554 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,0369213 0,08638757 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0369213 0,08629978 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0369213 0,08621216 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,0369213 0,08612472 ! prophase GO:0051324 11 8 0,000 0,0369213 0,08603747 ! S phase GO:0051320 8 8 0,000 0,0369213 0,08595038 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0369213 0,08586348 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,0369213 0,08577675 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0369213 0,08569019 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0369213 0,08560381 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0369213 0,0855176 ! hormone catabolic process GO:0042447 13 8 0,000 0,0369213 0,08543157 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0369213 0,08534571 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,0369213 0,08526002 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,0369213 0,0851745 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0369213 0,08508916 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,0369213 0,08500398 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0369213 0,08491898 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0369213 0,08483414 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,0369213 0,08474948 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,0369213 0,08466498 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0369213 0,08458066 ! lamellipodium assembly GO:0030032 9 8 0,000 0,0369213 0,0844965 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,0369213 0,0844125 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,0369213 0,08432868 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,0369213 0,08424502 ! defense response to bacterium GO:0042742 73 65 1,000 0,0373676 0,08517886 ! antigen processing and presentation GO:0019882 96 66 1,000 0,03842034 0,08749187 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,03842034 0,08740533 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,03948438 0,08973722 ! telencephalon cell migration GO:0022029 16 9 0,000 0,04144072 0,09409048 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,04144072 0,09399769 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04144072 0,09390508 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04144072 0,09381266 ! CTP metabolic process GO:0046036 9 9 0,000 0,04144072 0,09372041 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04144072 0,09362835 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,04144072 0,09353647 ! GTP metabolic process GO:0046039 9 9 0,000 0,04144072 0,09344476 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04144072 0,09335324 ! social behavior GO:0035176 14 9 0,000 0,04144072 0,0932619 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,04144072 0,09317073 ! artery development GO:0060840 19 9 0,000 0,04144072 0,09307975 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04144072 0,09298894 ! response to pain GO:0048265 16 9 0,000 0,04144072 0,0928983 ! protein complex disassembly GO:0043241 17 9 0,000 0,04144072 0,09280785 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04144072 0,09271757 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04144072 0,09262746 ! lung alveolus development GO:0048286 17 9 0,000 0,04144072 0,09253753 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04144072 0,09244778 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,04144072 0,0923582 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04144072 0,09226879 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04144072 0,09217955 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04144072 0,09209049 ! protein targeting to ER GO:0045047 19 9 0,000 0,04144072 0,0920016 ! T cell selection GO:0045058 18 9 0,000 0,04144072 0,09191288 ! endoderm development GO:0007492 12 9 0,000 0,04144072 0,09182433 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04144072 0,09173596 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04144072 0,09164775 ! arginine catabolic process GO:0006527 10 9 0,000 0,04144072 0,09155971 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,04144072 0,09147184 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,04144072 0,09138414 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,04144072 0,09129661 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04144072 0,09120924 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,04144072 0,09112204 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,04144072 0,09103501 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04144072 0,09094815 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04144072 0,09086145 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04144072 0,09077491 ! mannose metabolic process GO:0006013 9 9 0,000 0,04144072 0,09068854 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04144072 0,09060234 ! receptor clustering GO:0043113 15 9 0,000 0,04144072 0,0905163 ! epithelial cell development GO:0002064 10 9 0,000 0,04144072 0,09043042 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04144072 0,0903447 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04144072 0,09025915 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,04144072 0,09017376 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04144072 0,09008852 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04144072 0,09000346 ! motor axon guidance GO:0008045 14 9 0,000 0,04144072 0,08991855 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,04144072 0,0898338 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,04144072 0,08974921 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04144072 0,08966478 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04144072 0,08958051 ! DNA ligation GO:0006266 14 9 0,000 0,04144072 0,08949639 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04144072 0,08941244 ! response to amine stimulus GO:0014075 13 9 0,000 0,04144072 0,08932864 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04144072 0,089245 ! erythrocyte development GO:0048821 11 9 0,000 0,04144072 0,08916151 ! renal water homeostasis GO:0003091 14 9 0,000 0,04144072 0,08907819 ! postreplication repair GO:0006301 11 9 0,000 0,04144072 0,08899501 ! mRNA cleavage GO:0006379 13 9 0,000 0,04144072 0,088912 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04144072 0,08882913 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,04144072 0,08874642 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04144072 0,08866387 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04144072 0,08858147 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,04144072 0,08849922 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04144072 0,08841712 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,04144072 0,08833518 ! acid secretion GO:0046717 14 9 0,000 0,04144072 0,08825339 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04144072 0,08817175 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04144072 0,08809026 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04144072 0,08800892 ! purine base metabolic process GO:0006144 18 9 0,000 0,04144072 0,08792773 ! oocyte differentiation GO:0009994 12 9 0,000 0,04144072 0,08784669 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,04144072 0,0877658 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04144072 0,08768506 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,04144072 0,08760447 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04144072 0,08752402 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04144072 0,08744372 ! detection of calcium ion GO:0005513 13 9 0,000 0,04144072 0,08736357 ! blastocyst formation GO:0001825 12 9 0,000 0,04144072 0,08728357 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04144072 0,08720371 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,04144072 0,087124 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04144072 0,08704444 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04144072 0,08696502 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04144072 0,08688574 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04144072 0,08680661 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,04144072 0,08672762 ! prepulse inhibition GO:0060134 14 9 0,000 0,04144072 0,08664878 ! embryonic placenta development GO:0001892 12 9 0,000 0,04144072 0,08657008 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,04144072 0,08649152 ! insulin secretion GO:0030073 17 9 0,000 0,04144072 0,08641311 ! response to nicotine GO:0035094 16 9 0,000 0,04144072 0,08633484 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04144072 0,08625671 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04144072 0,08617872 ! localization within membrane GO:0051668 15 9 0,000 0,04144072 0,08610087 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,0416458 0,08644886 ! response to drug GO:0042493 108 69 1,000 0,0416458 0,08637091 ! response to metal ion GO:0010038 103 70 1,000 0,04274294 0,08856645 ! humoral immune response GO:0006959 86 70 1,000 0,04274294 0,08848673 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,04274294 0,08840716 ! regulation of catabolic process GO:0009894 106 70 1,000 0,04274294 0,08832773 ! muscle cell differentiation GO:0042692 104 71 1,000 0,04385086 0,0905359 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,04385086 0,0904547 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,04496945 0,09267898 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of muscle development GO:0048635 12 10 0,000 0,0459392 0,0945928 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,0459392 0,09450819 ! neuron fate specification GO:0048665 11 10 0,000 0,0459392 0,09442373 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,0459392 0,09433942 ! thyroid gland development GO:0030878 19 10 0,000 0,0459392 0,09425527 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,0459392 0,09417126 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,0459392 0,0940874 ! synapsis GO:0007129 13 10 0,000 0,0459392 0,09400369 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,0459392 0,09392014 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,0459392 0,09383673 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,0459392 0,09375346 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,0459392 0,09367035 ! sulfate transport GO:0008272 12 10 0,000 0,0459392 0,09358738 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,0459392 0,09350456 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,0459392 0,09342189 ! phospholipid efflux GO:0033700 16 10 0,000 0,0459392 0,09333936 ! hippocampus development GO:0021766 19 10 0,000 0,0459392 0,09325697 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,0459392 0,09317474 ! blood vessel remodeling GO:0001974 21 10 0,000 0,0459392 0,09309265 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,0459392 0,0930107 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,0459392 0,09292889 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,0459392 0,09284723 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,0459392 0,09276572 ! pathogenesis GO:0009405 13 10 0,000 0,0459392 0,09268434 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,0459392 0,09260311 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0459392 0,09252202 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,0459392 0,09244108 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,0459392 0,09236027 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,0459392 0,09227961 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,0459392 0,09219909 ! melanocyte differentiation GO:0030318 15 10 0,000 0,0459392 0,0921187 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,0459392 0,09203846 GO:0005978|glycogen biosynthetic process, ! reverse cholesterol transport GO:0043691 16 10 0,000 0,0459392 0,09195836 ! B cell proliferation GO:0042100 14 10 0,000 0,0459392 0,09187839 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,0459392 0,09179857 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,0459392 0,09171888 ! forebrain cell migration GO:0021885 17 10 0,000 0,0459392 0,09163933 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,0459392 0,09155992 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,0459392 0,09148065 ! UV protection GO:0009650 14 10 0,000 0,0459392 0,09140152 ! entry into host cell GO:0030260 20 10 0,000 0,0459392 0,09132252 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,0459392 0,09124366 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,0459392 0,09116493 ! negative regulation of ossification GO:0030279 19 10 0,000 0,0459392 0,09108634 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,0459392 0,09100788 ! regulation of bone resorption GO:0045124 24 10 0,000 0,0459392 0,09092956 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,0459392 0,09085138 ! regulation of organ growth GO:0046620 11 10 0,000 0,0459392 0,09077333 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,0459392 0,09069541 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,0459392 0,09061763 ! embryonic axis specification GO:0000578 12 10 0,000 0,0459392 0,09053998 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,0459392 0,09046246 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,0459392 0,09038507 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,0459392 0,09030782 ! cranial nerve development GO:0021545 12 10 0,000 0,0459392 0,0902307 ! fucose catabolic process GO:0019317 16 10 0,000 0,0459392 0,09015371 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,0459392 0,09007686 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,0459392 0,09000013 ! protein sumoylation GO:0016925 12 10 0,000 0,0459392 0,08992353 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,0459392 0,08984707 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0459392 0,08977073 ! zymogen activation GO:0031638 14 10 0,000 0,0459392 0,08969453 ! salivary gland development GO:0007431 22 10 0,000 0,0459392 0,08961845 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,0459392 0,0895425 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,0459392 0,08946668 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,0459392 0,08939099 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,0459392 0,08931543 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,0459392 0,08923999 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,0459392 0,08916469 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,0459392 0,0890895 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,0459392 0,08901445 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,0459392 0,08893952 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,0459392 0,08886472 ! detection of bacterium GO:0016045 10 10 0,000 0,0459392 0,08879004 ! embryonic gut development GO:0048566 11 10 0,000 0,0459392 0,08871549 ! activation of innate immune response GO:0002218 10 10 0,000 0,0459392 0,08864107 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,0459392 0,08856677 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,0459392 0,08849259 ! developmental induction GO:0031128 13 10 0,000 0,0459392 0,08841854 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,0459392 0,08834461 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,0459392 0,0882708 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,0459392 0,08819712 ! tube morphogenesis GO:0035239 118 73 1,000 0,04609859 0,08842931 ! digestion GO:0007586 97 74 1,000 0,04723814 0,09053977 ! blood coagulation GO:0007596 116 75 1,000 0,04838799 0,09266643 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,04838799 0,09258934 ! amine biosynthetic process GO:0009309 97 76 1,000 0,04954803 0,09473023 ! rRNA transcription GO:0009303 17 11 0,000 0,05041682 0,0963112 ! respiratory burst GO:0045730 14 11 0,000 0,05041682 0,09623127 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,05041682 0,09615148 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,05041682 0,09607181 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,05041682 0,09599228 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,05041682 0,09591289 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,05041682 0,09583362 ! RNA polyadenylation GO:0043631 19 11 0,000 0,05041682 0,09575448 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,05041682 0,09567548 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,05041682 0,0955966 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,05041682 0,09551786 ! T cell proliferation GO:0042098 20 11 0,000 0,05041682 0,09543924 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,05041682 0,09536076 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,05041682 0,0952824 ! bone resorption GO:0045453 16 11 0,000 0,05041682 0,09520417 ! regulated secretory pathway GO:0045055 14 11 0,000 0,05041682 0,09512607 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,05041682 0,0950481 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,05041682 0,09497025 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,05041682 0,09489254 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,05041682 0,09481495 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,05041682 0,09473748 ! syncytium formation GO:0006949 15 11 0,000 0,05041682 0,09466015 ! plasma membrane organization GO:0007009 18 11 0,000 0,05041682 0,09458294 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,05041682 0,09450585 ! mitotic spindle organization GO:0007052 15 11 0,000 0,05041682 0,09442889 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,05041682 0,09435206 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,05041682 0,09427535 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,05041682 0,09419876 ! adult heart development GO:0007512 11 11 0,000 0,05041682 0,0941223 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,05041682 0,09404597 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,05041682 0,09396976 ! temperature homeostasis GO:0001659 16 11 0,000 0,05041682 0,09389367 ! L-glutamate transport GO:0015813 16 11 0,000 0,05041682 0,0938177 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,05041682 0,09374186 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,05041682 0,09366614 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,05041682 0,09359054 ! stem cell development GO:0048864 29 11 0,000 0,05041682 0,09351506 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,05041682 0,09343971 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,05041682 0,09336448 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,05041682 0,09328936 ! vasoconstriction GO:0042310 15 11 0,000 0,05041682 0,09321437 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,05041682 0,0931395 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,05041682 0,09306475 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,05041682 0,09299012 ! ribosome assembly GO:0042255 13 11 0,000 0,05041682 0,09291561 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,05041682 0,09284122 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,05041682 0,09276694 ! chromatin silencing GO:0006342 19 11 0,000 0,05041682 0,09269279 ! nucleosome positioning GO:0016584 13 11 0,000 0,05041682 0,09261875 ! T cell homeostasis GO:0043029 20 11 0,000 0,05041682 0,09254484 ! regulation of isotype switching GO:0045191 19 11 0,000 0,05041682 0,09247104 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,05041682 0,09239735 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,05041682 0,09232379 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,05041682 0,09225034 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,05041682 0,09217701 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,05041682 0,0921038 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,05041682 0,0920307 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,05041682 0,09195772 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,05041682 0,09188485 ! male genitalia development GO:0030539 13 11 0,000 0,05041682 0,0918121 ! cholesterol efflux GO:0033344 19 11 0,000 0,05041682 0,09173946 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,05041682 0,09166694 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,05041682 0,09159453 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,05041682 0,09152224 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,05041682 0,09145006 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,05041682 0,091378 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,05041682 0,09130605 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,05041682 0,09123421 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,05041682 0,09116248 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,05041682 0,09109087 ! lysogeny GO:0030069 18 11 0,000 0,05041682 0,09101937 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,05041682 0,09094798 ! acrosome reaction GO:0007340 13 11 0,000 0,05041682 0,09087671 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,05041682 0,09080554 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,05071813 0,09127676 ! gland development GO:0048732 148 77 1,000 0,05071813 0,0912054 ! lactation GO:0007595 20 12 0,000 0,05487368 0,09860114 ! reproductive cellular process GO:0048610 14 12 0,000 0,05487368 0,09852417 ! tRNA modification GO:0006400 14 12 0,000 0,05487368 0,09844732 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,05487368 0,09837058 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,05487368 0,09829397 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,05487368 0,09821748 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,05487368 0,0981411 ! non-recombinational repair GO:0000726 19 12 0,000 0,05487368 0,09806485 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,05487368 0,09798871 ! peroxisomal transport GO:0043574 21 12 0,000 0,05487368 0,09791269 ! cartilage condensation GO:0001502 18 12 0,000 0,05487368 0,09783679 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,05487368 0,09776101 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,05487368 0,09768534 ! heart looping GO:0001947 15 12 0,000 0,05487368 0,09760979 ! palate development GO:0060021 15 12 0,000 0,05487368 0,09753436 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,05487368 0,09745904 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,05487368 0,09738384 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,05487368 0,09730876 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,05487368 0,09723379 ! arginine metabolic process GO:0006525 13 12 0,000 0,05487368 0,09715894 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,05487368 0,0970842 ! methionine metabolic process GO:0006555 13 12 0,000 0,05487368 0,09700958 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,05487368 0,09693507 ! Golgi organization GO:0007030 18 12 0,000 0,05487368 0,09686068 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,05487368 0,0967864 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,05487368 0,09671223 ! monoamine transport GO:0015844 13 12 0,000 0,05487368 0,09663818 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05487368 0,09656424 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,05487368 0,09649041 ! L-amino acid transport GO:0015807 20 12 0,000 0,05487368 0,0964167 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,05487368 0,0963431 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,05487368 0,09626961 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,05487368 0,09619624 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05487368 0,09612297 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,05487368 0,09604982 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,05487368 0,09597678 ! cerebellum development GO:0021549 13 12 0,000 0,05487368 0,09590385 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,05487368 0,09583103 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,05487368 0,09575832 ! histone methylation GO:0016571 15 12 0,000 0,05487368 0,09568572 ! autonomic nervous system development GO:0048483 23 12 0,000 0,05487368 0,09561323 ! gland morphogenesis GO:0022612 23 12 0,000 0,05487368 0,09554085 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,05487368 0,09546858 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,05487368 0,09539642 ! regulation of epidermis development GO:0045682 17 12 0,000 0,05487368 0,09532437 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,05487368 0,09525242 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,05487368 0,09518059 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,05487368 0,09510886 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,05487368 0,09503724 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,05487368 0,09496573 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,05487368 0,09489433 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,05487368 0,09482304 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,05487368 0,09475185 ! response to cold GO:0009409 14 12 0,000 0,05487368 0,09468077 ! mRNA transport GO:0051028 121 81 1,000 0,05549685 0,09568422 ! hemostasis GO:0007599 125 81 1,000 0,05549685 0,09561255 ! detection of stimulus GO:0051606 108 82 1,000 0,05671553 0,09763901 ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,05794359 0,09967857 ! sterol metabolic process GO:0016125 120 84 1,000 0,0591809 0,10173099 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,05930988 0,10187656 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,05930988 0,10180053 ! cGMP metabolic process GO:0046068 16 13 0,000 0,05930988 0,10172462 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,05930988 0,10164882 ! water transport GO:0006833 17 13 0,000 0,05930988 0,10157313 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,05930988 0,10149755 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,05930988 0,10142209 ! lipid localization GO:0010876 24 13 0,000 0,05930988 0,10134674 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,05930988 0,1012715 ! organelle fusion GO:0048284 28 13 0,000 0,05930988 0,10119637 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,05930988 0,10112136 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,05930988 0,10104645 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,05930988 0,10097166 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,05930988 0,10089698 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,05930988 0,1008224 ! response to hexose stimulus GO:0009746 19 13 0,000 0,05930988 0,10074794 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,05930988 0,10067359 ! glutamate metabolic process GO:0006536 18 13 0,000 0,05930988 0,10059935 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,05930988 0,10052521 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,05930988 0,10045119 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,05930988 0,10037727 ! NAD metabolic process GO:0019674 21 13 0,000 0,05930988 0,10030347 ! exocrine system development GO:0035272 27 13 0,000 0,05930988 0,10022977 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,05930988 0,10015618 ! bone mineralization GO:0030282 15 13 0,000 0,05930988 0,10008269 ! regulation of exocytosis GO:0017157 17 13 0,000 0,05930988 0,10000932 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,05930988 0,09993605 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,05930988 0,09986289 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,05930988 0,09978984 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,05930988 0,0997169 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,05930988 0,09964406 ! genitalia development GO:0048806 15 13 0,000 0,05930988 0,09957132 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,05930988 0,0994987 ! cellular pigmentation GO:0033059 24 13 0,000 0,05930988 0,09942618 ! tissue regeneration GO:0042246 21 13 0,000 0,05930988 0,09935376 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,05930988 0,09928145 ! cofactor transport GO:0051181 19 13 0,000 0,05930988 0,09920925 ! NADP metabolic process GO:0006739 18 13 0,000 0,05930988 0,09913715 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,05930988 0,09906515 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,05930988 0,09899326 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05930988 0,09892147 ! gas transport GO:0015669 18 13 0,000 0,05930988 0,09884979 ! regulation of RNA stability GO:0043487 28 13 0,000 0,05930988 0,09877821 ! heme biosynthetic process GO:0006783 20 13 0,000 0,05930988 0,09870674 ! regulation of axon extension GO:0030516 23 13 0,000 0,05930988 0,09863537 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,05930988 0,0985641 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,05930988 0,09849293 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,05930988 0,09842187 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,05930988 0,09835091 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,05930988 0,09828005 ! transcription initiation GO:0006352 118 85 1,000 0,06042736 0,10005971 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,06042736 0,09998773 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,06042736 0,09991584 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,0629473 0,10400775 GO:0060538|skeletal muscle organ development, ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,0637255 0,10521799 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,0637255 0,10514251 ! superoxide anion generation GO:0042554 18 14 0,000 0,0637255 0,10506714 ! neuron maturation GO:0042551 21 14 0,000 0,0637255 0,10499187 ! regulation of S phase GO:0033261 18 14 0,000 0,0637255 0,10491672 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,0637255 0,10484167 ! myotube differentiation GO:0014902 21 14 0,000 0,0637255 0,10476673 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,0637255 0,1046919 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,0637255 0,10461717 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,0637255 0,10454255 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,0637255 0,10446804 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,0637255 0,10439363 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,0637255 0,10431933 ! gene silencing by RNA GO:0031047 20 14 0,000 0,0637255 0,10424513 ! response to cAMP GO:0051591 19 14 0,000 0,0637255 0,10417104 ! limbic system development GO:0021761 25 14 0,000 0,0637255 0,10409706 ! startle response GO:0001964 21 14 0,000 0,0637255 0,10402318 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,0637255 0,1039494 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,0637255 0,10387573 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,0637255 0,10380216 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,0637255 0,1037287 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,0637255 0,10365534 ! glycine metabolic process GO:0006544 22 14 0,000 0,0637255 0,10358209 ! pituitary gland development GO:0021983 23 14 0,000 0,0637255 0,10350894 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,0637255 0,10343589 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,0637255 0,10336294 ! regulation of heart rate GO:0002027 23 14 0,000 0,0637255 0,1032901 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,0637255 0,10321736 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,0637255 0,10314473 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,0637255 0,10307219 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,0637255 0,10299976 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,0637255 0,10292743 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! axon cargo transport GO:0008088 27 14 0,000 0,0637255 0,1028552 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,0637255 0,10278307 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,0637255 0,10271104 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,0637255 0,10263911 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,0637255 0,10256729 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,0637255 0,10249556 ! mRNA splice site selection GO:0006376 26 14 0,000 0,0637255 0,10242394 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,0637255 0,10235241 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,0637255 0,10228099 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,0637255 0,10220966 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,0637255 0,10213844 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,0637255 0,10206731 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,0637255 0,10199628 ! muscle maintenance GO:0046716 19 14 0,000 0,0637255 0,10192535 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,0637255 0,10185452 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,0637255 0,10178379 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,0637255 0,10171315 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,0637255 0,10164262 ! cell killing GO:0001906 20 14 0,000 0,0637255 0,10157218 ! cilium assembly GO:0042384 20 14 0,000 0,0637255 0,10150184 ! peptide hormone secretion GO:0030072 23 14 0,000 0,0637255 0,1014316 ! establishment of RNA localization GO:0051236 128 88 1,000 0,06422055 0,10214887 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 1,000 0,06422055 0,10207828 ! reproductive developmental process GO:0003006 127 89 1,000 0,06550252 0,10404405 ! RNA localization GO:0006403 135 91 1,000 0,06809215 0,10808278 ! response to virus GO:0009615 122 91 1,000 0,06809215 0,10800824 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,06812065 0,10797898 ! positive regulation of cell size GO:0045793 20 15 0,000 0,06812065 0,10790462 ! metencephalon development GO:0022037 19 15 0,000 0,06812065 0,10783035 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,06812065 0,10775619 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,06812065 0,10768213 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,06812065 0,10760818 ! skin development GO:0043588 25 15 0,000 0,06812065 0,10753432 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,06812065 0,10746057 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,06812065 0,10738691 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,06812065 0,10731336 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,06812065 0,10723991 ! bile acid metabolic process GO:0008206 22 15 0,000 0,06812065 0,10716656 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,06812065 0,1070933 ! adult walking behavior GO:0007628 25 15 0,000 0,06812065 0,10702015 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,06812065 0,1069471 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,06812065 0,10687415 ! myoblast differentiation GO:0045445 27 15 0,000 0,06812065 0,1068013 ! centrosome cycle GO:0007098 16 15 0,000 0,06812065 0,10672855 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,06812065 0,10665589 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,06812065 0,10658334 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,06812065 0,10651088 ! cerebral cortex development GO:0021987 29 15 0,000 0,06812065 0,10643852 ! response to osmotic stress GO:0006970 22 15 0,000 0,06812065 0,10636626 ! vesicle coating GO:0006901 25 15 0,000 0,06812065 0,1062941 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,06812065 0,10622204 ! DNA integration GO:0015074 22 15 0,000 0,06812065 0,10615007 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,06812065 0,1060782 ! peptide secretion GO:0002790 27 15 0,000 0,06812065 0,10600643 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,06812065 0,10593476 ! regulation of vasodilation GO:0042312 24 15 0,000 0,06812065 0,10586318 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,06812065 0,1057917 ! neuron recognition GO:0008038 22 15 0,000 0,06812065 0,10572031 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,06812065 0,10564903 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,06812065 0,10557783 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,06812065 0,10550674 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,06812065 0,10543574 ! biomineral formation GO:0031214 18 15 0,000 0,06812065 0,10536483 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,06812065 0,10529402 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,06812065 0,10522331 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,06812065 0,10515269 ! dopamine metabolic process GO:0042417 30 15 0,000 0,06812065 0,10508216 ! organic cation transport GO:0015695 19 15 0,000 0,06812065 0,10501173 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,06812065 0,1049414 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,06812065 0,10487115 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,06812065 0,10480101 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,06812065 0,10473095 ! peptide hormone processing GO:0016486 19 15 0,000 0,06812065 0,10466099 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,06812065 0,10459112 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,06939961 0,10648372 ! cell fate commitment GO:0045165 141 92 1,000 0,06939961 0,10641273 ! response to oxidative stress GO:0006979 141 94 1,000 0,07203928 0,11038664 ! protein secretion GO:0009306 27 16 0,000 0,07249542 0,11101163 ! hormone secretion GO:0046879 25 16 0,000 0,07249542 0,11093777 ! bone remodeling GO:0046849 24 16 0,000 0,07249542 0,11086401 ! endothelial cell migration GO:0043542 22 16 0,000 0,07249542 0,11079035 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,07249542 0,11071678 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07249542 0,11064331 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,07249542 0,11056994 ! glial cell development GO:0021782 24 16 0,000 0,07249542 0,11049667 ! patterning of blood vessels GO:0001569 24 16 0,000 0,07249542 0,11042349 ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,07249542 0,11035041 ! protein polyubiquitination GO:0000209 26 16 0,000 0,07249542 0,11027743 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,07249542 0,11020454 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,07249542 0,11013175 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,07249542 0,11005906 ! fructose metabolic process GO:0006000 20 16 0,000 0,07249542 0,10998646 ! regulation of protein binding GO:0043393 27 16 0,000 0,07249542 0,10991396 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,07249542 0,10984155 ! negative regulation of immune response GO:0050777 28 16 0,000 0,07249542 0,10976924 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,07249542 0,10969702 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,07249542 0,1096249 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,07249542 0,10955287 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,07249542 0,10948094 ! diencephalon development GO:0021536 25 16 0,000 0,07249542 0,1094091 ! oogenesis GO:0048477 23 16 0,000 0,07249542 0,10933736 ! neural crest cell migration GO:0001755 24 16 0,000 0,07249542 0,10926571 ! G1 phase GO:0051318 27 16 0,000 0,07249542 0,10919416 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,07249542 0,10912269 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,07249542 0,10905132 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,07249542 0,10898005 ! steroid catabolic process GO:0006706 22 16 0,000 0,07249542 0,10890887 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,07249542 0,10883778 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,07249542 0,10876678 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,07249542 0,10869588 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,07249542 0,10862507 ! sperm-egg recognition GO:0035036 16 16 0,000 0,07249542 0,10855435 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,07249542 0,10848372 ! nerve development GO:0021675 18 16 0,000 0,07249542 0,10841318 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,07249542 0,10834274 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,07249542 0,10827239 ! angiogenesis GO:0001525 149 95 1,000 0,07337128 0,10950938 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,07471127 0,11143704 ! in utero embryonic development GO:0001701 147 96 1,000 0,07471127 0,11136482 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,07471127 0,11129269 ! protein amino acid glycosylation GO:0006486 134 97 1,000 0,07605912 0,11322717 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,07684991 0,11433039 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,07684991 0,11425649 ! negative regulation of defense response GO:0031348 19 17 0,000 0,07684991 0,11418268 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,07684991 0,11410896 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,07684991 0,11403534 ! glycerol metabolic process GO:0006071 20 17 0,000 0,07684991 0,11396182 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,07684991 0,11388839 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,07684991 0,11381506 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,07684991 0,11374182 ! signal complex assembly GO:0007172 29 17 0,000 0,07684991 0,11366867 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,07684991 0,11359562 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,07684991 0,11352266 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,07684991 0,1134498 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,07684991 0,11337703 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,07684991 0,11330435 ! memory GO:0007613 25 17 0,000 0,07684991 0,11323176 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,07684991 0,11315927 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,07684991 0,11308687 ! retinoid metabolic process GO:0001523 22 17 0,000 0,07684991 0,11301457 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,07684991 0,11294235 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,07684991 0,11287023 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,07684991 0,1127982 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,07684991 0,11272626 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,07684991 0,11265442 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,07684991 0,11258266 ! membrane budding GO:0006900 29 17 0,000 0,07684991 0,112511 ! heme metabolic process GO:0042168 27 17 0,000 0,07684991 0,11243943 ! neuromuscular junction development GO:0007528 23 17 0,000 0,07684991 0,11236795 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,07684991 0,11229656 ! body fluid secretion GO:0007589 27 17 0,000 0,07684991 0,11222526 ! stem cell differentiation GO:0048863 36 17 0,000 0,07684991 0,11215405 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,07684991 0,11208293 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,07684991 0,1120119 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,07684991 0,11194096 ! sensory perception of pain GO:0019233 23 17 0,000 0,07684991 0,11187012 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,07684991 0,11179936 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,07684991 0,11172869 ! synaptogenesis GO:0007416 24 17 0,000 0,07684991 0,11165811 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,07684991 0,11158762 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,07684991 0,11151721 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,07684991 0,1114469 ! cell-cell junction organization GO:0045216 25 17 0,000 0,07684991 0,11137667 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,07684991 0,11130654 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,07684991 0,11123649 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,07684991 0,11116653 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,07684991 0,11109666 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,07684991 0,11102687 ! extracellular structure organization GO:0043062 156 99 1,000 0,07877806 0,11374107 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,07877806 0,11366972 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,08014893 0,11557526 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,08118419 0,11699476 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,08118419 0,1169215 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,08118419 0,11684834 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,08118419 0,11677526 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,08118419 0,11670228 ! cAMP metabolic process GO:0046058 33 18 0,000 0,08118419 0,11662938 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,08118419 0,11655658 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,08118419 0,11648387 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,08118419 0,11641125 ! axis specification GO:0009798 26 18 0,000 0,08118419 0,11633872 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,08118419 0,11626628 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,08118419 0,11619393 ! pancreas development GO:0031016 26 18 0,000 0,08118419 0,11612167 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,08118419 0,1160495 ! glutamine metabolic process GO:0006541 23 18 0,000 0,08118419 0,11597742 ! response to retinoic acid GO:0032526 25 18 0,000 0,08118419 0,11590543 ! pigmentation during development GO:0048066 31 18 0,000 0,08118419 0,11583352 ! central nervous system neuron development GO:0021954 30 18 0,000 0,08118419 0,11576171 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,08118419 0,11568999 ! fucose metabolic process GO:0006004 26 18 0,000 0,08118419 0,11561835 ! response to fungus GO:0009620 19 18 0,000 0,08118419 0,11554681 ! peptide cross-linking GO:0018149 31 18 0,000 0,08118419 0,11547535 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,08118419 0,11540398 ! heart process GO:0003015 27 18 0,000 0,08118419 0,1153327 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,08118419 0,11526151 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,08118419 0,1151904 ! visual learning GO:0008542 35 18 0,000 0,08118419 0,11511938 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,08118419 0,11504845 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,08118419 0,11497761 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,08118419 0,11490686 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,08118419 0,11483619 ! vitamin transport GO:0051180 24 18 0,000 0,08118419 0,11476561 ! hormone transport GO:0009914 27 18 0,000 0,08118419 0,11469511 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,08118419 0,1146247 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,08118419 0,11455438 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,08118419 0,11448415 ! cell-cell recognition GO:0009988 20 18 0,000 0,08118419 0,114414 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,08118419 0,11434393 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,08118419 0,11427395 ! regulation of glucose import GO:0046324 21 18 0,000 0,08118419 0,11420406 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,08118419 0,11413425 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,08118419 0,11406453 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,08118419 0,1139949 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,08549837 0,11997942 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,08549837 0,11990626 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,08549837 0,11983319 ! positive regulation of ossification GO:0045778 30 19 0,000 0,08549837 0,11976021 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,08549837 0,11968732 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,08549837 0,11961451 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,08549837 0,1195418 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,08549837 0,11946918 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,08549837 0,11939664 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,08549837 0,11932419 ! regeneration GO:0031099 32 19 0,000 0,08549837 0,11925183 ! sensory perception of taste GO:0050909 23 19 0,000 0,08549837 0,11917955 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,08549837 0,11910737 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,08549837 0,11903527 ! smooth muscle contraction GO:0006939 36 19 0,000 0,08549837 0,11896326 ! peroxisome organization GO:0007031 29 19 0,000 0,08549837 0,11889133 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,08549837 0,11881949 ! response to vitamin A GO:0033189 26 19 0,000 0,08549837 0,11874774 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,08549837 0,11867608 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,08549837 0,1186045 ! plasma membrane fusion GO:0045026 23 19 0,000 0,08549837 0,11853301 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,08549837 0,1184616 ! cytolysis GO:0019835 20 19 0,000 0,08549837 0,11839028 ! renal system process GO:0003014 35 19 0,000 0,08549837 0,11831905 ! vasodilation GO:0042311 33 19 0,000 0,08549837 0,1182479 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,08549837 0,11817684 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,08549837 0,11810586 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,08549837 0,11803497 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,08549837 0,11796416 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,08549837 0,11789344 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,08549837 0,11782281 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,08549837 0,11775225 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,08549837 0,11768178 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,08549837 0,1176114 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,08549837 0,1175411 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,08549837 0,11747089 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,08549837 0,11740075 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,08549837 0,11733071 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,08549837 0,11726074 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,08979255 0,12307679 ! iron ion transport GO:0006826 37 20 0,000 0,08979255 0,12300349 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,08979255 0,12293027 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,08979255 0,12285714 ! response to vitamin GO:0033273 29 20 0,000 0,08979255 0,1227841 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,08979255 0,12271115 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,08979255 0,12263828 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,08979255 0,12256549 ! spinal cord development GO:0021510 31 20 0,000 0,08979255 0,1224928 ! response to ethanol GO:0045471 37 20 0,000 0,08979255 0,12242019 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,08979255 0,12234767 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,08979255 0,12227523 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,08979255 0,12220288 ! chromosome condensation GO:0030261 31 20 0,000 0,08979255 0,12213061 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,08979255 0,12205843 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,08979255 0,12198633 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,08979255 0,12191432 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,08979255 0,12184239 ! pallium development GO:0021543 38 20 0,000 0,08979255 0,12177055 ! DNA modification GO:0006304 28 20 0,000 0,08979255 0,1216988 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,08979255 0,12162713 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,08979255 0,12155554 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,08979255 0,12148403 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,08979255 0,12141262 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,08979255 0,12134128 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,08979255 0,12127003 ! collagen catabolic process GO:0030574 25 20 0,000 0,08979255 0,12119886 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,08979255 0,12112778 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,08979255 0,12105678 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,08979255 0,12098586 ! alditol metabolic process GO:0019400 24 20 0,000 0,08979255 0,12091502 ! actin filament-based movement GO:0030048 34 20 0,000 0,08979255 0,12084427 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,0940668 0,1265226 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,0940668 0,12644865 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,0940668 0,12637479 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,0940668 0,12630102 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,0940668 0,12622733 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,0940668 0,12615373 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,0940668 0,12608021 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,0940668 0,12600678 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,0940668 0,12593344 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,0940668 0,12586018 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,0940668 0,125787 ! vesicle docking GO:0048278 27 21 0,000 0,0940668 0,12571391 ! phototransduction GO:0007602 25 21 0,000 0,0940668 0,12564091 ! dendrite development GO:0016358 35 21 0,000 0,0940668 0,12556799 ! visual behavior GO:0007632 39 21 0,000 0,0940668 0,12549515 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,0940668 0,1254224 ! ovarian follicle development GO:0001541 30 21 0,000 0,0940668 0,12534973 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,0940668 0,12527715 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,0940668 0,12520465 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,0940668 0,12513224 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,0940668 0,12505991 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,0940668 0,12498766 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,0940668 0,1249155 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,0940668 0,12484342 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,0940668 0,12477142 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,0940668 0,12469951 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,0940668 0,12462767 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,0940668 0,12455592 ! fatty acid transport GO:0015908 30 21 0,000 0,0940668 0,12448426 ! immunoglobulin production GO:0002377 33 21 0,000 0,0940668 0,12441267 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,0940668 0,12434117 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,0940668 0,12426975 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,0940668 0,12419842 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,0940668 0,12412716 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,0940668 0,12405599 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,0940668 0,12398489 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,0940668 0,12391388 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,0940668 0,12384295 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,0940668 0,12377211 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,0940668 0,12370134 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,0940668 0,12363065 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,0940668 0,12356005 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,0940668 0,12348952 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,0940668 0,12341908 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,09832123 0,12892749 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,09832123 0,12885403 ! viral genome replication GO:0019079 29 22 0,000 0,09832123 0,12878065 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,09832123 0,12870735 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,09832123 0,12863414 ! leukocyte adhesion GO:0007159 38 22 0,000 0,09832123 0,12856101 ! molting cycle process GO:0022404 40 22 0,000 0,09832123 0,12848797 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,09832123 0,128415 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,09832123 0,12834212 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,09832123 0,12826932 ! vasculogenesis GO:0001570 33 22 0,000 0,09832123 0,12819661 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,09832123 0,12812398 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,09832123 0,12805143 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,09832123 0,12797896 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,09832123 0,12790657 ! lysosome organization GO:0007040 37 22 0,000 0,09832123 0,12783427 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,09832123 0,12776205 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,09832123 0,1276899 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,09832123 0,12761784 ! regulation of behavior GO:0050795 38 22 0,000 0,09832123 0,12754587 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,09832123 0,12747397 ! membrane depolarization GO:0051899 35 22 0,000 0,09832123 0,12740215 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,09832123 0,12733042 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,09832123 0,12725876 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,09832123 0,12718719 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,09832123 0,12711569 ! blastocyst development GO:0001824 37 22 0,000 0,09832123 0,12704428 ! neural tube closure GO:0001843 33 22 0,000 0,09832123 0,12697295 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,09832123 0,12690169 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,10255591 0,1322931 ! neuron fate commitment GO:0048663 32 23 0,000 0,10255591 0,13221895 ! embryonic pattern specification GO:0009880 31 23 0,000 0,10255591 0,13214488 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,10255591 0,13207089 ! myelination GO:0042552 35 23 0,000 0,10255591 0,13199698 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,10255591 0,13192316 ! vesicle targeting GO:0006903 32 23 0,000 0,10255591 0,13184941 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,10255591 0,13177576 ! osteoblast differentiation GO:0001649 40 23 0,000 0,10255591 0,13170218 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,10255591 0,13162868 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,10255591 0,13155527 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,10255591 0,13148194 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,10255591 0,13140869 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,10255591 0,13133553 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,10255591 0,13126244 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,10255591 0,13118943 ! cell fate determination GO:0001709 45 23 0,000 0,10255591 0,13111651 ! pentose metabolic process GO:0019321 31 23 0,000 0,10255591 0,13104367 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,10255591 0,13097091 ! spermatid development GO:0007286 33 23 0,000 0,10255591 0,13089823 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,10255591 0,13082563 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,10255591 0,13075311 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,10255591 0,13068067 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,10255591 0,13060831 ! telomere organization GO:0032200 32 23 0,000 0,10255591 0,13053603 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,10255591 0,13046383 ! regulation of amine transport GO:0051952 38 23 0,000 0,10255591 0,13039171 ! liver development GO:0001889 40 23 0,000 0,10255591 0,13031967 ! initiation of viral infection GO:0019059 42 24 0,000 0,10677096 0,13560088 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,10677096 0,13552605 ! superoxide metabolic process GO:0006801 32 24 0,000 0,10677096 0,1354513 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,10677096 0,13537663 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,10677096 0,13530204 ! fat cell differentiation GO:0045444 37 24 0,000 0,10677096 0,13522753 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,10677096 0,13515311 ! sperm motility GO:0030317 27 24 0,000 0,10677096 0,13507877 ! vacuole organization GO:0007033 39 24 0,000 0,10677096 0,13500451 ! receptor metabolic process GO:0043112 37 24 0,000 0,10677096 0,13493033 ! neural crest cell development GO:0014032 39 24 0,000 0,10677096 0,13485623 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,10677096 0,13478222 ! primary neural tube formation GO:0014020 35 24 0,000 0,10677096 0,13470828 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,10677096 0,13463443 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,10677096 0,13456066 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,10677096 0,13448697 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,10677096 0,13441335 ! glutathione metabolic process GO:0006749 29 24 0,000 0,10677096 0,13433982 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,10677096 0,13426637 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,10677096 0,13419301 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,10677096 0,13411972 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,11096644 0,13931376 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,11096644 0,13923776 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,11096644 0,13916184 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,11096644 0,139086 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,11096644 0,13901025 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,11096644 0,13893458 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,11096644 0,13885899 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,11096644 0,13878348 ! peptide transport GO:0015833 43 25 0,000 0,11096644 0,13870805 ! male gonad development GO:0008584 33 25 0,000 0,11096644 0,13863271 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,11096644 0,13855745 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,11096644 0,13848227 ! phospholipid transport GO:0015914 35 25 0,000 0,11096644 0,13840717 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,11096644 0,13833215 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,11096644 0,13825721 ! detection of light stimulus GO:0009583 30 25 0,000 0,11096644 0,13818236 ! leukocyte proliferation GO:0070661 39 25 0,000 0,11096644 0,13810758 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,11096644 0,13803289 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,11514246 0,14315009 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,11514246 0,14307275 ! translational initiation GO:0006413 43 26 0,000 0,11514246 0,1429955 ! circadian rhythm GO:0007623 42 26 0,000 0,11514246 0,14291833 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,11514246 0,14284124 ! post-embryonic development GO:0009791 42 26 0,000 0,11514246 0,14276424 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,11514246 0,14268732 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,11514246 0,14261048 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,11514246 0,14253372 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,11514246 0,14245705 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,11514246 0,14238046 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,11514246 0,14230395 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,11514246 0,14222753 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,11514246 0,14215118 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,1192991 0,14720383 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,1192991 0,1471249 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,1192991 0,14704605 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,1192991 0,14696729 ! membrane docking GO:0022406 39 27 0,000 0,1192991 0,14688861 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,1192991 0,14681002 ! catechol metabolic process GO:0009712 43 27 0,000 0,1192991 0,14673151 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,1192991 0,14665309 ! acute-phase response GO:0006953 42 27 0,000 0,1192991 0,14657475 ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,1192991 0,14649649 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,1192991 0,14641832 ! natural killer cell activation GO:0030101 35 27 0,000 0,1192991 0,14634023 ! lipid oxidation GO:0034440 38 27 0,000 0,1192991 0,14626222 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,1192991 0,1461843 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,1192991 0,14610646 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,1192991 0,1460287 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,1192991 0,14595103 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,1192991 0,14587343 ! gene silencing GO:0016458 41 27 0,000 0,1192991 0,14579593 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,12343645 0,15077209 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,12343645 0,15069206 ! phenol metabolic process GO:0018958 44 28 0,000 0,12343645 0,15061212 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,12343645 0,15053226 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,12343645 0,15045249 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,12343645 0,1503728 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,12343645 0,15029319 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,12343645 0,15021367 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,12343645 0,15013424 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,12343645 0,15005488 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,12343645 0,14997562 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,12343645 0,14989643 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,12343645 0,14981733 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,12343645 0,14973831 ! mesoderm formation GO:0001707 46 28 0,000 0,12343645 0,14965938 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,12343645 0,14958053 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,12343645 0,14950176 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,12343645 0,14942307 ! ensheathment of neurons GO:0007272 43 28 0,000 0,12343645 0,14934447 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,12343645 0,14926595 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,12343645 0,14918751 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,12343645 0,14910916 ! neural tube formation GO:0001841 41 28 0,000 0,12343645 0,14903089 ! placenta development GO:0001890 37 28 0,000 0,12343645 0,1489527 ! regulation of B cell activation GO:0050864 42 28 0,000 0,12343645 0,14887459 ! regulation of innate immune response GO:0045088 38 29 0,000 0,1275546 0,15376079 ! ovulation cycle process GO:0022602 41 29 0,000 0,1275546 0,15368024 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,1275546 0,15359978 ! protein targeting to membrane GO:0006612 53 29 0,000 0,1275546 0,15351941 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,1275546 0,15343911 ! mismatch repair GO:0006298 34 29 0,000 0,1275546 0,15335891 ! formation of primary germ layer GO:0001704 48 29 0,000 0,1275546 0,15327878 ! telencephalon development GO:0021537 52 29 0,000 0,1275546 0,15319874 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,1275546 0,15311878 ! eye morphogenesis GO:0048592 51 29 0,000 0,1275546 0,15303891 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,1275546 0,15295912 ! tissue homeostasis GO:0001894 42 29 0,000 0,1275546 0,15287941 GO:0048871|multicellular organismal homeostasis, ! collagen metabolic process GO:0032963 40 30 0,000 0,13165364 0,15771009 ! organic anion transport GO:0015711 51 30 0,000 0,13165364 0,15762799 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,13165364 0,15754598 ! spliceosome assembly GO:0000245 49 30 0,000 0,13165364 0,15746405 ! spindle organization GO:0007051 37 30 0,000 0,13165364 0,15738221 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,13165364 0,15730046 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,13165364 0,15721878 ! ceramide metabolic process GO:0006672 43 30 0,000 0,13165364 0,1571372 ! ovulation cycle GO:0042698 43 30 0,000 0,13165364 0,15705569 ! hindbrain development GO:0030902 45 30 0,000 0,13165364 0,15697428 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,13165364 0,15689294 ! adult locomotory behavior GO:0008344 47 30 0,000 0,13165364 0,15681169 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,13165364 0,15673053 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,13165364 0,15664944 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,13165364 0,15656845 ! response to heat GO:0009408 41 30 0,000 0,13165364 0,15648753 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,13165364 0,1564067 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,13165364 0,15632596 ! glial cell differentiation GO:0010001 55 31 0,000 0,13573366 0,16108741 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,13573366 0,16100434 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,13573366 0,16092134 ! odontogenesis GO:0042476 50 31 0,000 0,13573366 0,16083844 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,13573366 0,16075562 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,13573366 0,16067288 ! metanephros development GO:0001656 58 31 0,000 0,13573366 0,16059023 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,13573366 0,16050767 ! cell fate specification GO:0001708 37 31 0,000 0,13573366 0,16042518 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,13573366 0,16034279 GO:0060326|cell chemotaxis, ! RNA modification GO:0009451 40 31 0,000 0,13573366 0,16026048 ! regulation of muscle development GO:0048634 48 32 0,000 0,13979473 0,16497069 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,13979473 0,16488609 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,13979473 0,16480158 ! meiosis I GO:0007127 52 32 0,000 0,13979473 0,16471715 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,13979473 0,16463281 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,13979473 0,16454856 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,13979473 0,16446439 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 0,000 0,13979473 0,16438031 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,13979473 0,16429631 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,13979473 0,1642124 ! cytokine production GO:0001816 44 32 0,000 0,13979473 0,16412858 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,13979473 0,16404484 ! vesicle localization GO:0051648 47 32 0,000 0,13979473 0,16396118 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,14383696 0,16861621 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,14383696 0,16853031 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,14383696 0,1684445 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,14383696 0,16835878 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,14383696 0,16827314 ! sister chromatid segregation GO:0000819 46 33 0,000 0,14383696 0,1681876 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,14383696 0,16810214 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,14383696 0,16801676 ! female gonad development GO:0008585 49 33 0,000 0,14383696 0,16793147 ! positive regulation of cell development GO:0010720 54 33 0,000 0,14383696 0,16784627 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,14383696 0,16776116 ! regulation of proteolysis GO:0030162 50 33 0,000 0,14383696 0,16767613 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,14383696 0,16759119 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,14383696 0,16750633 ! cytokinesis GO:0000910 52 33 0,000 0,14383696 0,16742156 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,14383696 0,16733688 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,14786042 0,17193072 ! mRNA catabolic process GO:0006402 48 34 0,000 0,14786042 0,17184384 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,14786042 0,17175705 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,14786042 0,17167035 ! feeding behavior GO:0007631 45 34 0,000 0,14786042 0,17158373 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,14786042 0,17149721 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,14786042 0,17141077 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,14786042 0,17132441 ! neuron migration GO:0001764 46 34 0,000 0,14786042 0,17123815 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,14786042 0,17115197 ! female gamete generation GO:0007292 43 34 0,000 0,14786042 0,17106588 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,14786042 0,17097987 ! aerobic respiration GO:0009060 47 34 0,000 0,14786042 0,17089395 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,14786042 0,17080812 ! embryonic organ development GO:0048568 45 34 0,000 0,14786042 0,17072237 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,14786042 0,17063671 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,1518652 0,17517049 ! Notch signaling pathway GO:0007219 56 35 0,000 0,1518652 0,17508269 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,1518652 0,17499497 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,1518652 0,17490734 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,1518652 0,1748198 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,1518652 0,17473235 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,1518652 0,17464498 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,1518652 0,1745577 ! glycogen metabolic process GO:0005977 48 35 0,000 0,1518652 0,17447051 ! pigment metabolic process GO:0042440 61 35 0,000 0,1518652 0,17438341 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,1518652 0,17429639 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,1518652 0,17420946 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,15585139 0,17869302 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,15585139 0,17860399 ! organic ether metabolic process GO:0018904 46 36 0,000 0,15585139 0,17851504 ! tissue remodeling GO:0048771 62 36 0,000 0,15585139 0,17842618 ! neural tube development GO:0021915 50 36 0,000 0,15585139 0,17833741 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,15585139 0,17824873 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,15585139 0,17816014 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,15585139 0,17807163 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,15585139 0,17798322 ! glucan metabolic process GO:0044042 49 36 0,000 0,15585139 0,17789489 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,15981907 0,18233327 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,15981907 0,18224287 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,15981907 0,18215256 ! learning GO:0007612 67 37 0,000 0,15981907 0,18206234 ! ion transmembrane transport GO:0034220 56 37 0,000 0,15981907 0,18197221 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,15981907 0,18188217 ! amino acid activation GO:0043038 52 37 0,000 0,15981907 0,18179222 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,15981907 0,18170236 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,16376833 0,18610038 ! gliogenesis GO:0042063 71 38 0,000 0,16376833 0,18600848 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,16376833 0,18591667 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,16376833 0,18582495 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,16376833 0,18573332 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,16769925 0,19009773 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,16769925 0,19000408 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,16769925 0,18991053 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,16769925 0,18981707 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,16769925 0,1897237 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,16769925 0,18963043 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,16769925 0,18953724 ! male sex differentiation GO:0046661 53 39 0,000 0,16769925 0,18944415 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,16769925 0,18935115 ! JNK cascade GO:0007254 54 39 0,000 0,16769925 0,18925824 ! developmental growth GO:0048589 62 39 0,000 0,16769925 0,18916542 ! cell growth GO:0016049 61 39 0,000 0,16769925 0,18907269 ! synapse organization GO:0050808 55 39 0,000 0,16769925 0,18898005 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,17161192 0,19329453 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,17161192 0,19319991 ! regulation of tube size GO:0035150 60 40 0,000 0,17161192 0,19310539 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,17161192 0,19301096 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,17161192 0,19291663 ! peptide metabolic process GO:0006518 56 40 0,000 0,17161192 0,19282238 ! inner ear development GO:0048839 57 40 0,000 0,17161192 0,19272823 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,17161192 0,19263417 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! JAK-STAT cascade GO:0007259 53 40 0,000 0,17161192 0,19254021 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,17161192 0,19244633 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,17550642 0,19671772 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,17550642 0,1966219 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,17550642 0,19652618 ! endosome transport GO:0016197 71 41 0,000 0,17550642 0,19643054 ! striated muscle contraction GO:0006941 62 41 0,000 0,17550642 0,196335 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,17550642 0,19623955 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,17550642 0,1961442 ! biopolymer methylation GO:0043414 62 41 0,000 0,17550642 0,19604894 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,17550642 0,19595377 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,17938283 0,20018462 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,17938283 0,20008754 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,17938283 0,19999055 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,17938283 0,19989366 ! excretion GO:0007588 63 42 0,000 0,17938283 0,19979686 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,17938283 0,19970015 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,17938283 0,19960354 ! regulation of cell shape GO:0008360 78 42 0,000 0,17938283 0,19950702 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 0,000 0,18324124 0,20369978 ! leukocyte migration GO:0050900 60 43 0,000 0,18324124 0,20360137 ! neuromuscular process GO:0050905 79 43 0,000 0,18324124 0,20350306 ! tRNA processing GO:0008033 49 43 0,000 0,18324124 0,20340485 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,18324124 0,20330673 ! vesicle organization GO:0016050 79 43 0,000 0,18324124 0,2032087 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,18324124 0,20311077 ! methylation GO:0032259 64 43 0,000 0,18324124 0,20301293 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,18708172 0,20716801 ! glycolysis GO:0006096 53 44 0,000 0,18708172 0,20706831 ! regulation of ion transport GO:0043269 57 44 0,000 0,18708172 0,20696872 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,18708172 0,20686921 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,18708172 0,2067698 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,18708172 0,20667049 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,18708172 0,20657127 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,18708172 0,20647215 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,18708172 0,20637312 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,18708172 0,20627419 ! RNA catabolic process GO:0006401 64 45 0,000 0,19090437 0,21038814 ! positive regulation of defense response GO:0031349 59 45 0,000 0,19090437 0,21028738 ! regulation of translational initiation GO:0006446 64 45 0,000 0,19090437 0,21018671 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,19090437 0,21008615 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,19090437 0,20998567 ! cell recognition GO:0008037 58 45 0,000 0,19090437 0,2098853 ! cell maturation GO:0048469 60 45 0,000 0,19090437 0,20978502 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,19470926 0,21386403 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,19470926 0,21376195 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,19470926 0,21365997 ! regulation of ossification GO:0030278 71 46 0,000 0,19470926 0,21355808 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,19470926 0,21345629 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,19849647 0,21750447 ! viral infectious cycle GO:0019058 71 47 0,000 0,19849647 0,21740089 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,19849647 0,21729742 ! endocrine system development GO:0035270 83 47 0,000 0,19849647 0,21719404 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,19849647 0,21709076 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,19849647 0,21698758 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,19849647 0,2168845 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,19849647 0,21678152 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,19849647 0,21667863 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of protein polymerization GO:0032271 71 47 0,000 0,19849647 0,21657584 ! chloride transport GO:0006821 67 48 0,000 0,20226609 0,22058416 ! response to temperature stimulus GO:0009266 62 48 0,000 0,20226609 0,22047962 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,20226609 0,22037518 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,20226609 0,22027083 ! gastrulation GO:0007369 73 48 0,000 0,20226609 0,22016659 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,20226609 0,22006244 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,20226609 0,21995839 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,20226609 0,21985444 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,20601819 0,22382704 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,20601819 0,22372136 ! sensory perception of smell GO:0007608 61 49 0,000 0,20601819 0,22361578 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,20601819 0,2235103 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,20601819 0,22340492 ! RNA elongation GO:0006354 62 49 0,000 0,20601819 0,22329964 ! germ cell development GO:0007281 68 49 0,000 0,20601819 0,22319446 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,20601819 0,22308938 ! cartilage development GO:0051216 70 49 0,000 0,20601819 0,22298439 ! regulation of actin filament length GO:0030832 72 50 0,000 0,20975286 0,22691984 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,20975286 0,22681315 ! membrane fusion GO:0006944 80 50 0,000 0,20975286 0,22670657 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,20975286 0,22660008 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,20975286 0,2264937 ! proton transport GO:0015992 75 50 0,000 0,20975286 0,22638741 ! positive regulation of secretion GO:0051047 71 51 0,000 0,21347018 0,23029147 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 0,000 0,21347018 0,2301835 ! hydrogen transport GO:0006818 77 51 0,000 0,21347018 0,23007564 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,21347018 0,22996787 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,21347018 0,22986021 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,21347018 0,22975265 ! adult behavior GO:0030534 80 51 0,000 0,21347018 0,22964519 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,21347018 0,22953783 ! transition metal ion transport GO:0000041 74 52 0,000 0,21717022 0,23340725 ! regulation of cellular component size GO:0032535 74 52 0,000 0,21717022 0,23329823 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,21717022 0,23318931 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,21717022 0,2330805 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,22085307 0,2369226 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,22085307 0,23681215 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,22085307 0,2367018 ! single fertilization GO:0007338 59 53 0,000 0,22085307 0,23659155 ! amino acid transport GO:0006865 84 54 0,000 0,2245188 0,24040654 ! glucose catabolic process GO:0006007 66 54 0,000 0,2245188 0,24029467 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,2245188 0,2401829 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,2245188 0,24007124 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,2245188 0,23995968 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,2245188 0,23984823 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,2245188 0,23973688 ! exocytosis GO:0006887 74 55 0,000 0,2281675 0,24351983 ! mesoderm development GO:0007498 76 55 0,000 0,2281675 0,24340688 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,2281675 0,24329404 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,2281675 0,2431813 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,23179923 0,24693758 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,23541409 0,25067241 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,23541409 0,25055641 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,23541409 0,25044052 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,23541409 0,25032473 ! camera-type eye development GO:0043010 88 57 0,000 0,23541409 0,25020906 ! secondary metabolic process GO:0019748 84 57 0,000 0,23541409 0,25009349 ! developmental maturation GO:0021700 75 57 0,000 0,23541409 0,24997802 ! gonad development GO:0008406 79 57 0,000 0,23541409 0,24986267 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,23901214 0,25356454 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,24259346 0,25724526 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,24615814 0,26090494 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,24615814 0,26078476 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,24615814 0,2606647 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,24615814 0,26054474 ! fertilization GO:0009566 68 60 0,000 0,24615814 0,26042489 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,24970624 0,26405717 ! meiosis GO:0007126 96 61 0,000 0,24970624 0,26393582 GO:0051327|M phase of meiotic cell cycle, ! homeostasis of number of cells GO:0048872 84 61 0,000 0,24970624 0,26381459 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,24970624 0,26369346 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,24970624 0,26357244 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,24970624 0,26345154 ! amine catabolic process GO:0009310 90 62 0,000 0,25323784 0,26705504 ! neurotransmitter transport GO:0006836 81 62 0,000 0,25323784 0,26693265 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,25323784 0,26681037 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,25323784 0,26668821 ! meiotic cell cycle GO:0051321 97 62 0,000 0,25323784 0,26656615 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,25675303 0,27014271 ! regulation of lipase activity GO:0060191 109 63 0,000 0,25675303 0,27001919 ! appendage morphogenesis GO:0035107 93 64 0,000 0,26025187 0,27357372 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,26025187 0,27344874 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,26025187 0,27332388 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,26025187 0,27319913 ! hexose catabolic process GO:0019320 82 64 0,000 0,26025187 0,27307449 ! reproductive structure development GO:0048608 90 65 0,000 0,26373443 0,27660246 ! appendage development GO:0048736 94 65 0,000 0,26373443 0,27647639 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,26373443 0,27635043 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,26373443 0,27622459 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,26373443 0,27609886 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,26373443 0,27597325 ! activation of immune response GO:0002253 83 65 0,000 0,26373443 0,27584775 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,2672008 0,27934629 ! axon guidance GO:0007411 99 66 0,000 0,2672008 0,27921938 ! regulation of immune effector process GO:0002697 101 66 0,000 0,2672008 0,27909257 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,27065105 0,28256805 ! acute inflammatory response GO:0002526 92 68 0,000 0,27408525 0,28602363 ! learning or memory GO:0007611 123 68 0,000 0,27408525 0,28589392 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,27408525 0,28576432 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,27408525 0,28563484 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,27408525 0,28550547 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,27408525 0,28537623 ! rhythmic process GO:0048511 105 68 0,000 0,27408525 0,2852471 ! inorganic anion transport GO:0015698 93 68 0,000 0,27408525 0,28511808 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,27750348 0,2885434 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,27750348 0,28841302 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,28090581 0,29181723 ! eye development GO:0001654 111 70 0,000 0,28090581 0,29168549 ! amine transport GO:0015837 101 70 0,000 0,28090581 0,29155386 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,28090581 0,29142235 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,28429231 0,29480266 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,28429231 0,29466981 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,28429231 0,29453707 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,28429231 0,29440446 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,28766305 0,29776103 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,28766305 0,29762709 ! regulation of blood pressure GO:0008217 107 73 0,000 0,29101811 0,30096298 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,29101811 0,30082771 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,29101811 0,30069257 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,29435756 0,30400647 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,29435756 0,30387002 ! response to nutrient GO:0007584 104 75 0,000 0,29768148 0,30716348 ! regulation of ligase activity GO:0051340 114 75 0,000 0,29768148 0,30702574 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,29768148 0,30688812 ! tRNA metabolic process GO:0006399 95 76 0,000 0,30098992 0,31015987 ! response to unfolded protein GO:0006986 99 76 0,000 0,30098992 0,31002097 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,30098992 0,3098822 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,30428297 0,31313237 ! sex differentiation GO:0007548 105 77 0,000 0,30428297 0,31299233 ! protein ubiquitination GO:0016567 125 77 0,000 0,30428297 0,31285241 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,30428297 0,31271262 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,30428297 0,31257295 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,30428297 0,31243341 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,3075607 0,31565801 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,3075607 0,31551722 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,3075607 0,31537655 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,31082317 0,3185799 ! cellular respiration GO:0045333 107 79 0,000 0,31082317 0,31843799 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,31082317 0,31829621 ! regulation of lyase activity GO:0051339 133 79 0,000 0,31082317 0,31815456 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,31082317 0,31801303 ! chromatin assembly GO:0031497 102 80 0,000 0,31407045 0,32119255 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,31407045 0,3210498 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,31407045 0,32090717 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,31407045 0,32076467 ! forebrain development GO:0030900 131 80 0,000 0,31407045 0,3206223 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,31730262 0,32377819 ! response to protein stimulus GO:0051789 111 81 0,000 0,31730262 0,3236346 ! regulation of neurological system process GO:0031644 122 81 0,000 0,31730262 0,32349115 ! vitamin metabolic process GO:0006766 103 81 0,000 0,31730262 0,32334782 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,31730262 0,32320462 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,32051975 0,32633706 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,3237219 0,32945149 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell adhesion GO:0030155 159 83 0,000 0,3237219 0,32930578 ! regulation of defense response GO:0031347 117 84 0,000 0,32690914 0,33240098 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,32690914 0,33225409 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,32690914 0,33210734 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,33008154 0,33518214 ! rRNA metabolic process GO:0016072 107 85 0,000 0,33008154 0,33503422 GO:0006364|rRNA processing, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,33323917 0,33809003 ! interphase of mitotic cell cycle GO:0051329 156 86 0,000 0,33323917 0,33794096 ! nucleosome organization GO:0034728 114 87 0,000 0,3363821 0,34097789 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,3363821 0,34082768 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,3363821 0,3406776 ! female pregnancy GO:0007565 130 87 0,000 0,3363821 0,34052765 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,3363821 0,34037784 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,33951039 0,34339222 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,33951039 0,34324128 ! interphase GO:0051325 159 88 0,000 0,33951039 0,34309047 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,33951039 0,34293979 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,34262412 0,34593304 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,34262412 0,34578125 ! regulation of T cell activation GO:0050863 128 89 0,000 0,34262412 0,34562959 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,34572334 0,34860311 ! hormone metabolic process GO:0042445 121 90 0,000 0,34572334 0,34845035 ! ATP metabolic process GO:0046034 137 91 0,000 0,34880813 0,35140548 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,35187856 0,35434356 ! positive regulation of immune response GO:0050778 121 92 0,000 0,35187856 0,35418848 ! DNA recombination GO:0006310 146 92 0,000 0,35187856 0,35403354 ! sulfur metabolic process GO:0006790 118 92 0,000 0,35187856 0,35387874 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,35493468 0,35679623 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,35493468 0,35664035 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,35493468 0,35648461 ! electron transport chain GO:0022900 123 94 0,000 0,35797657 0,35938285 ! carboxylic acid transport GO:0046942 147 95 0,000 0,36100428 0,36226433 GO:0015849|organic acid transport, ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,36401789 0,36512915 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,36701746 0,3679774 ! calcium ion transport GO:0006816 167 99 0,000 0,37297474 0,37378732 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,37593258 0,37658751 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,37593258 0,37642357 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,37593258 0,37625976 ! divalent metal ion transport GO:0070838 171 100 0,000 0,37593258 0,3760961 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,37593258 0,37593258