pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/532-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of lipid kinase activity GO:0043550 12 7 5,000 7,698E-14 1,771E-10 ! positive regulation of pseudopodium assembly GO:0031274 13 5 3,000 2,593E-09 2,981E-06 GO:0031272|regulation of pseudopodium assembly, ! interphase of mitotic cell cycle GO:0051329 156 86 7,000 8,703E-09 6,672E-06 ! interphase GO:0051325 159 88 7,000 1,046E-08 6,015E-06 ! trophectodermal cell differentiation GO:0001829 8 7 3,000 1,801E-08 8,286E-06 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 3,000 3,589E-08 1,376E-05 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 3,714E-08 1,22E-05 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 5,000 5,831E-08 1,676E-05 ! blastocyst formation GO:0001825 12 9 3,000 6,437E-08 1,645E-05 ! regulation of cell projection assembly GO:0060491 20 10 3,000 1,069E-07 2,458E-05 ! positive regulation of cell migration GO:0030335 92 51 5,000 1,67E-07 3,491E-05 ! cell cycle arrest GO:0007050 150 86 6,000 1,969E-07 3,774E-05 ! regulation of lipid metabolic process GO:0019216 84 56 5,000 2,953E-07 5,224E-05 ! positive regulation of cell motion GO:0051272 99 56 5,000 2,953E-07 4,851E-05 ! lung development GO:0030324 94 59 5,000 4,05E-07 6,21E-05 ! regulation of homeostatic process GO:0032844 105 60 5,000 4,483E-07 6,444E-05 ! regulation of erythrocyte differentiation GO:0045646 27 14 3,000 5,02E-07 6,791E-05 ! respiratory tube development GO:0030323 99 62 5,000 5,462E-07 6,979E-05 ! respiratory system development GO:0060541 100 64 5,000 6,61E-07 8,002E-05 ! G1 phase GO:0051318 27 16 3,000 9,059E-07 1,042E-04 ! positive regulation of glycolysis GO:0045821 11 5 2,000 1,102E-06 1,206E-04 ! nuclear migration GO:0007097 10 5 2,000 1,102E-06 1,152E-04 ! regulation of myeloid cell differentiation GO:0045637 69 40 4,000 1,389E-06 1,389E-04 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 3,000 1,908E-06 1,829E-04 ! regulation of gene-specific transcription GO:0032583 69 43 4,000 2,008E-06 1,848E-04 ! macrophage differentiation GO:0030225 10 6 2,000 2,195E-06 1,942E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 2,195E-06 1,87E-04 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 3,555E-06 2,92E-04 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 3,561E-06 2,824E-04 ! blastocyst development GO:0001824 37 22 3,000 3,561E-06 2,73E-04 ! establishment of nucleus localization GO:0040023 13 7 2,000 3,828E-06 2,84E-04 ! positive regulation of cell projection organization GO:0031346 39 24 3,000 5,135E-06 3,691E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 5,135E-06 3,579E-04 ! establishment of organelle localization GO:0051656 85 52 4,000 5,239E-06 3,544E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 6,104E-06 4,011E-04 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 2,000 6,104E-06 3,9E-04 ! in utero embryonic development GO:0001701 147 96 5,000 7,221E-06 4,489E-04 ! regulation of developmental growth GO:0048638 13 9 2,000 9,124E-06 5,522E-04 ! positive regulation of glucose metabolic process GO:0010907 15 9 2,000 9,124E-06 5,381E-04 ! regulation of glycolysis GO:0006110 15 9 2,000 9,124E-06 5,246E-04 ! lung alveolus development GO:0048286 17 9 2,000 9,124E-06 5,118E-04 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 2,000 9,124E-06 4,996E-04 ! embryonic placenta development GO:0001892 12 9 2,000 9,124E-06 4,88E-04 ! nucleus localization GO:0051647 15 9 2,000 9,124E-06 4,769E-04 ! organelle localization GO:0051640 96 62 4,000 1,256E-05 6,418E-04 ! protein sumoylation GO:0016925 12 10 2,000 1,299E-05 6,494E-04 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 2,000 1,299E-05 6,356E-04 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of gene-specific transcription GO:0043193 47 31 3,000 1,482E-05 7,099E-04 ! filopodium assembly GO:0046847 19 11 2,000 1,78E-05 8,353E-04 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 1,78E-05 8,186E-04 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 2,159E-05 9,739E-04 ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 2,364E-05 1,046E-03 ! auditory receptor cell differentiation GO:0042491 25 12 2,000 2,364E-05 1,026E-03 ! heart looping GO:0001947 15 12 2,000 2,364E-05 1,007E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 2,000 2,364E-05 9,888E-04 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! microspike assembly GO:0030035 23 12 2,000 2,364E-05 9,711E-04 ! response to hypoxia GO:0001666 132 72 4,000 2,614E-05 1,055E-03 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 2,986E-05 1,184E-03 ! response to oxygen levels GO:0070482 137 74 4,000 2,986E-05 1,164E-03 ! negative regulation of growth GO:0045926 123 75 4,000 3,188E-05 1,222E-03 ! G1 phase of mitotic cell cycle GO:0000080 23 14 2,000 3,885E-05 1,465E-03 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 2,000 3,885E-05 1,441E-03 ! muscle maintenance GO:0046716 19 14 2,000 3,885E-05 1,418E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 3,885E-05 1,396E-03 ! regulation of muscle cell differentiation GO:0051147 24 15 2,000 4,839E-05 1,712E-03 ! regulation of cell shape GO:0008360 78 42 3,000 5,06E-05 1,763E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 5,558E-05 1,908E-03 ! regulation of glucose metabolic process GO:0010906 22 16 2,000 5,935E-05 2,007E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 5,935E-05 1,978E-03 ! inner ear receptor cell differentiation GO:0060113 30 16 2,000 5,935E-05 1,95E-03 ! regulation of cell projection organization GO:0031344 83 44 3,000 6,092E-05 1,973E-03 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 2,000 7,181E-05 2,294E-03 ! response to UV GO:0009411 75 46 3,000 7,269E-05 2,29E-03 ! mechanoreceptor differentiation GO:0042490 32 18 2,000 8,587E-05 2,669E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 8,587E-05 2,633E-03 ! heart morphogenesis GO:0003007 65 48 3,000 8,603E-05 2,604E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 8,603E-05 2,57E-03 ! ear development GO:0043583 72 50 3,000 1,011E-04 2,98E-03 ! positive regulation of growth GO:0045927 67 50 3,000 1,011E-04 2,943E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 1,016E-04 2,921E-03 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 1,016E-04 2,885E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of cellular component biogenesis GO:0044087 158 96 4,000 1,042E-04 2,923E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 1,385E-04 3,838E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 1,385E-04 3,792E-03 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 2,000 1,385E-04 3,747E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 1,385E-04 3,704E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 1,385E-04 3,661E-03 ! vasculogenesis GO:0001570 33 22 2,000 1,598E-04 4,176E-03 ! protein tetramerization GO:0051262 39 22 2,000 1,598E-04 4,13E-03 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 1,689E-04 4,317E-03 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 1,831E-04 4,628E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 1,831E-04 4,578E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 1,831E-04 4,529E-03 ! cellular response to oxidative stress GO:0034599 33 23 2,000 1,831E-04 4,481E-03 ! myeloid cell differentiation GO:0030099 85 59 3,000 1,932E-04 4,678E-03 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 2,085E-04 4,996E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 2,085E-04 4,945E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,314E-04 5,431E-03 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 2,314E-04 5,377E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 2,314E-04 5,323E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 2,314E-04 5,27E-03 ! embryonic hemopoiesis GO:0035162 10 5 1,000 2,314E-04 5,218E-03 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 1,000 2,314E-04 5,168E-03 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 2,314E-04 5,118E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 2,314E-04 5,069E-03 ! valine metabolic process GO:0006573 8 5 1,000 2,314E-04 5,021E-03 ! positive regulation of chemokine production GO:0032722 7 5 1,000 2,314E-04 4,975E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 2,314E-04 4,929E-03 ! apical protein localization GO:0045176 6 5 1,000 2,314E-04 4,883E-03 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 2,314E-04 4,839E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 2,314E-04 4,795E-03 ! negative regulation of cell growth GO:0030308 106 62 3,000 2,342E-04 4,81E-03 ! iron ion homeostasis GO:0055072 39 25 2,000 2,362E-04 4,807E-03 ! regulation of chromosome organization GO:0033044 35 25 2,000 2,362E-04 4,765E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 2,362E-04 4,723E-03 ! negative regulation of cell size GO:0045792 108 64 3,000 2,648E-04 5,251E-03 ! protein oligomerization GO:0051259 100 65 3,000 2,811E-04 5,527E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 3,328E-04 6,488E-03 ! positive regulation of catabolic process GO:0009896 40 28 2,000 3,328E-04 6,433E-03 ! placenta development GO:0001890 37 28 2,000 3,328E-04 6,38E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 3,46E-04 6,578E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 3,46E-04 6,524E-03 ! mRNA stabilization GO:0048255 15 6 1,000 3,46E-04 6,471E-03 GO:0043489|RNA stabilization, ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 3,46E-04 6,418E-03 ! ER overload response GO:0006983 7 6 1,000 3,46E-04 6,367E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 3,46E-04 6,317E-03 ! male sex determination GO:0030238 9 6 1,000 3,46E-04 6,267E-03 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 3,46E-04 6,218E-03 ! gas homeostasis GO:0033483 11 6 1,000 3,46E-04 6,17E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 3,46E-04 6,122E-03 ! positive regulation of smooth muscle contraction GO:0045987 9 6 1,000 3,46E-04 6,076E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 4,829E-04 8,415E-03 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 4,829E-04 8,351E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 4,829E-04 8,289E-03 ! T-helper 1 type immune response GO:0042088 11 7 1,000 4,829E-04 8,228E-03 ! hemoglobin metabolic process GO:0020027 10 7 1,000 4,829E-04 8,167E-03 ! asymmetric protein localization GO:0008105 8 7 1,000 4,829E-04 8,108E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 4,829E-04 8,049E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 4,829E-04 7,991E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 4,829E-04 7,934E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 4,829E-04 7,878E-03 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 4,829E-04 7,822E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 4,829E-04 7,767E-03 ! response to tumor cell GO:0002347 12 7 1,000 4,829E-04 7,713E-03 ! meiosis I GO:0007127 52 32 2,000 4,969E-04 7,882E-03 ! regulation of cell morphogenesis GO:0022604 140 76 3,000 5,116E-04 8,059E-03 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 5,447E-04 8,523E-03 ! carbohydrate homeostasis GO:0033500 39 33 2,000 5,447E-04 8,465E-03 GO:0042593|glucose homeostasis, ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 5,953E-04 9,19E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 6,419E-04 9,842E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 6,419E-04 9,777E-03 ! induction of positive chemotaxis GO:0050930 14 8 1,000 6,419E-04 9,712E-03 ! succinate metabolic process GO:0006105 14 8 1,000 6,419E-04 9,649E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 6,419E-04 9,586E-03 ! middle ear morphogenesis GO:0042474 9 8 1,000 6,419E-04 9,524E-03 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 6,419E-04 9,463E-03 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 6,419E-04 9,403E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 6,419E-04 9,344E-03 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 6,419E-04 9,285E-03 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 1,000 6,419E-04 9,227E-03 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 6,419E-04 9,17E-03 ! regulation of telomere maintenance GO:0032204 10 8 1,000 6,419E-04 9,113E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 6,419E-04 9,057E-03 ! tissue remodeling GO:0048771 62 36 2,000 7,054E-04 9,892E-03 ! Golgi vesicle transport GO:0048193 138 85 3,000 7,81E-04 0,01088722 ! phosphagen metabolic process GO:0006599 12 9 1,000 8,226E-04 0,01139816 GO:0006600|creatine metabolic process, ! positive regulation of muscle contraction GO:0045933 12 9 1,000 8,226E-04 0,01132991 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 8,226E-04 0,01126247 ! pigmentation GO:0043473 74 38 2,000 8,276E-04 0,011263 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 8,934E-04 0,01208741 ! inner ear development GO:0048839 57 40 2,000 9,625E-04 0,01294567 ! double-strand break repair GO:0006302 67 40 2,000 9,625E-04 0,0128704 ! leukocyte differentiation GO:0002521 143 90 3,000 9,677E-04 0,012865 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,025E-03 0,01354971 ! COPI coating of Golgi vesicle GO:0048205 14 10 1,000 1,025E-03 0,01347228 GO:0048200|Golgi transport vesicle coating, ! blood vessel remodeling GO:0001974 21 10 1,000 1,025E-03 0,01339574 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,025E-03 0,01332005 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,025E-03 0,01324522 ! response to X-ray GO:0010165 16 10 1,000 1,025E-03 0,01317123 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 1,025E-03 0,01309805 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 1,025E-03 0,01302569 ! regulation of bone resorption GO:0045124 24 10 1,000 1,025E-03 0,01295412 ! DNA methylation GO:0006306 15 10 1,000 1,025E-03 0,01288333 GO:0006305|DNA alkylation, ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,025E-03 0,01281331 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 1,094E-03 0,01359607 ! angiogenesis GO:0001525 149 95 3,000 1,184E-03 0,01463681 ! activation of caspase activity GO:0006919 65 43 2,000 1,19E-03 0,01463235 ! response to light stimulus GO:0009416 153 96 3,000 1,231E-03 0,01505528 ! virus-host interaction GO:0019048 17 11 1,000 1,249E-03 0,01519829 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,249E-03 0,0151183 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 1,249E-03 0,01503914 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 1,000 1,249E-03 0,01496081 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 1,249E-03 0,0148833 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 1,000 1,249E-03 0,01480658 ! regulation of intracellular pH GO:0051453 17 11 1,000 1,249E-03 0,01473065 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 1,249E-03 0,01465549 ! histone deacetylation GO:0016575 13 11 1,000 1,249E-03 0,0145811 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,249E-03 0,01450745 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 3,000 1,279E-03 0,0147804 ! positive regulation of cell cycle GO:0045787 77 45 2,000 1,358E-03 0,01562141 ! histone modification GO:0016570 68 46 2,000 1,448E-03 0,01657011 ! histone acetylation GO:0016573 23 12 1,000 1,494E-03 0,01701037 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,494E-03 0,01692658 ! response to gamma radiation GO:0010332 20 12 1,000 1,494E-03 0,0168436 ! regulation of mRNA stability GO:0043488 27 12 1,000 1,494E-03 0,01676144 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 1,494E-03 0,01668007 ! covalent chromatin modification GO:0016569 75 47 2,000 1,541E-03 0,01712688 ! positive regulation of caspase activity GO:0043280 72 48 2,000 1,638E-03 0,01811742 GO:0010952|positive regulation of peptidase activity, ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,76E-03 0,01936857 ! regulation of chemokine production GO:0032642 17 13 1,000 1,76E-03 0,01927633 ! regulation of cellular pH GO:0030641 20 13 1,000 1,76E-03 0,01918498 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,76E-03 0,01909448 ! cellular pigmentation GO:0033059 24 13 1,000 1,76E-03 0,01900484 ! regulation of RNA stability GO:0043487 28 13 1,000 1,76E-03 0,01891603 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 1,952E-03 0,0208838 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 2,047E-03 0,02179542 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 2,047E-03 0,02169498 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 1,000 2,047E-03 0,02159546 ! cellular response to starvation GO:0009267 21 14 1,000 2,047E-03 0,02149685 ! G1/S transition checkpoint GO:0031575 33 14 1,000 2,047E-03 0,02139914 ! DNA unwinding during replication GO:0006268 21 14 1,000 2,047E-03 0,02130231 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 2,047E-03 0,02120635 ! aging GO:0007568 79 52 2,000 2,064E-03 0,02129286 ! regulation of bone remodeling GO:0046850 90 53 2,000 2,181E-03 0,02239137 ! cell projection assembly GO:0030031 76 53 2,000 2,181E-03 0,02229185 ! regulation of protein complex assembly GO:0043254 81 54 2,000 2,301E-03 0,02341683 ! regulation of tissue remodeling GO:0034103 91 54 2,000 2,301E-03 0,02331367 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 2,354E-03 0,02374986 ! lipid phosphorylation GO:0046834 23 15 1,000 2,354E-03 0,02364615 ! myoblast differentiation GO:0045445 27 15 1,000 2,354E-03 0,02354334 ! regulation of survival gene product expression GO:0045884 20 15 1,000 2,354E-03 0,02344142 ! vesicle coating GO:0006901 25 15 1,000 2,354E-03 0,02334038 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 2,354E-03 0,0232402 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 2,354E-03 0,02314089 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 2,354E-03 0,02304241 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 2,354E-03 0,02294478 ! endothelial cell migration GO:0043542 22 16 1,000 2,682E-03 0,02602968 ! protein amino acid deacetylation GO:0006476 20 16 1,000 2,682E-03 0,02592031 ! protein amino acid acetylation GO:0006473 28 16 1,000 2,682E-03 0,02581186 ! cellular response to unfolded protein GO:0034620 19 16 1,000 2,682E-03 0,02570431 GO:0030968|endoplasmic reticulum unfolded protein response, ! neural crest cell migration GO:0001755 24 16 1,000 2,682E-03 0,02559765 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 2,682E-03 0,02549188 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 2,686E-03 0,02542362 ! negative regulation of kinase activity GO:0033673 100 58 2,000 2,823E-03 0,02660753 ! activation of MAPK activity GO:0000187 84 59 2,000 2,964E-03 0,02782134 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 1,000 3,03E-03 0,02833151 ! DNA duplex unwinding GO:0032508 25 17 1,000 3,03E-03 0,02821681 GO:0032392|DNA geometric change, ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 3,03E-03 0,02810303 ! membrane budding GO:0006900 29 17 1,000 3,03E-03 0,02799017 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 3,03E-03 0,0278782 ! meiosis GO:0007126 96 61 2,000 3,258E-03 0,02985528 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of transferase activity GO:0051348 105 61 2,000 3,258E-03 0,0297368 ! positive regulation of DNA replication GO:0045740 29 18 1,000 3,398E-03 0,03089351 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 3,398E-03 0,03077188 ! somitogenesis GO:0001756 24 18 1,000 3,398E-03 0,03065121 ! cellular response to nutrient levels GO:0031669 27 18 1,000 3,398E-03 0,03053148 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 3,398E-03 0,03041268 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 3,398E-03 0,0302948 ! meiotic cell cycle GO:0051321 97 62 2,000 3,412E-03 0,03029852 ! cell cycle checkpoint GO:0000075 108 64 2,000 3,733E-03 0,03301883 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 3,733E-03 0,03289232 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 3,786E-03 0,03323702 ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 3,786E-03 0,03311064 ! response to alkaloid GO:0043279 32 19 1,000 3,786E-03 0,03298522 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 3,786E-03 0,03286075 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 3,786E-03 0,03273721 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 3,786E-03 0,0326146 ! apoptotic nuclear changes GO:0030262 24 19 1,000 3,786E-03 0,03249291 ! response to starvation GO:0042594 30 19 1,000 3,786E-03 0,03237211 ! sex determination GO:0007530 29 19 1,000 3,786E-03 0,03225222 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 3,786E-03 0,03213321 ! regulation of caspase activity GO:0043281 97 65 2,000 3,9E-03 0,03297429 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 4,194E-03 0,03533049 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 4,194E-03 0,03520154 ! DNA modification GO:0006304 28 20 1,000 4,194E-03 0,03507354 ! positive regulation of locomotion GO:0040017 35 20 1,000 4,194E-03 0,03494646 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of B cell activation GO:0050871 31 20 1,000 4,194E-03 0,0348203 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 4,247E-03 0,03513775 ! response to drug GO:0042493 108 69 2,000 4,613E-03 0,03802706 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 4,62E-03 0,0379535 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 4,62E-03 0,03781843 ! protein amino acid acylation GO:0043543 37 21 1,000 4,62E-03 0,03768433 ! regulation of chemotaxis GO:0050920 36 21 1,000 4,62E-03 0,03755117 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 4,62E-03 0,03741894 ! cell aging GO:0007569 32 21 1,000 4,62E-03 0,03728765 ! response to cytokine stimulus GO:0034097 47 21 1,000 4,62E-03 0,03715727 ! positive regulation of phosphorylation GO:0042327 102 70 2,000 4,803E-03 0,03848819 ! regulation of catabolic process GO:0009894 106 70 2,000 4,803E-03 0,03835455 ! muscle cell differentiation GO:0042692 104 71 2,000 4,997E-03 0,03976953 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 5,066E-03 0,0401825 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 5,066E-03 0,04004442 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 5,066E-03 0,03990728 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 5,066E-03 0,03977108 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 5,066E-03 0,0396358 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 5,066E-03 0,03950144 ! regulation of behavior GO:0050795 38 22 1,000 5,066E-03 0,03936799 ! regulation of peptidase activity GO:0052547 106 72 2,000 5,196E-03 0,04024066 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 2,000 5,196E-03 0,04010563 GO:0045937|positive regulation of phosphate metabolic process, ! mitochondrion organization GO:0007005 104 73 2,000 5,4E-03 0,04153989 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 5,532E-03 0,04240872 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 5,532E-03 0,04226783 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 5,532E-03 0,04212787 ! negative regulation of DNA replication GO:0008156 35 23 1,000 5,532E-03 0,04198883 ! vesicle targeting GO:0006903 32 23 1,000 5,532E-03 0,04185071 ! interaction with host GO:0051701 37 23 1,000 5,532E-03 0,04171349 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 5,532E-03 0,04157717 ! protein import into nucleus GO:0006606 118 74 2,000 5,609E-03 0,04202058 ! nuclear import GO:0051170 121 75 2,000 5,822E-03 0,04347797 ! fat cell differentiation GO:0045444 37 24 1,000 6,015E-03 0,04477544 ! mitochondrial membrane organization GO:0007006 39 24 1,000 6,015E-03 0,044631 ! neural crest cell development GO:0014032 39 24 1,000 6,015E-03 0,0444875 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 6,015E-03 0,04434491 ! negative regulation of cell development GO:0010721 56 24 1,000 6,015E-03 0,04420323 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 6,015E-03 0,04406246 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 6,015E-03 0,04392258 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 6,015E-03 0,04378358 ! positive regulation of protein modification process GO:0031401 107 78 2,000 6,492E-03 0,04709969 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 6,518E-03 0,04714301 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of nuclear division GO:0051785 39 25 1,000 6,518E-03 0,04699523 GO:0045840|positive regulation of mitosis, ! protein localization in nucleus GO:0034504 133 80 2,000 6,962E-03 0,05004083 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 7,039E-03 0,05043545 ! regulation of pH GO:0006885 36 26 1,000 7,039E-03 0,05027882 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 7,039E-03 0,05012316 ! response to ionizing radiation GO:0010212 47 27 1,000 7,578E-03 0,05379657 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 8,136E-03 0,05757531 ! erythrocyte differentiation GO:0030218 38 28 1,000 8,136E-03 0,0573987 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 8,136E-03 0,05722317 ! regulation of B cell activation GO:0050864 42 28 1,000 8,136E-03 0,05704871 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 8,226E-03 0,05750556 ! transcription initiation GO:0006352 118 85 2,000 8,226E-03 0,0573313 ! skeletal muscle tissue development GO:0007519 123 87 2,000 8,767E-03 0,06091538 GO:0060538|skeletal muscle organ development, ! anatomical structure homeostasis GO:0060249 136 88 2,000 9,045E-03 0,06265786 ! collagen metabolic process GO:0032963 40 30 1,000 9,304E-03 0,06426066 ! spindle organization GO:0007051 37 30 1,000 9,304E-03 0,06406826 ! establishment of vesicle localization GO:0051650 45 30 1,000 9,304E-03 0,06387701 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 9,616E-03 0,06582335 ! DNA damage checkpoint GO:0000077 53 31 1,000 9,914E-03 0,06766438 ! mammary gland development GO:0030879 57 31 1,000 9,914E-03 0,06746419 ! segmentation GO:0035282 41 31 1,000 9,914E-03 0,06726518 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 9,914E-03 0,06706734 ! response to mechanical stimulus GO:0009612 43 31 1,000 9,914E-03 0,06687066 ! regulation of muscle development GO:0048634 48 32 1,000 0,01054213 0,07089735 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,01054213 0,07069065 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,01054213 0,07048516 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,01054213 0,07028085 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,01054213 0,07007773 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01054213 0,06987578 ! vesicle localization GO:0051648 47 32 1,000 0,01054213 0,06967498 ! response to oxidative stress GO:0006979 141 94 2,000 0,01082083 0,07131203 ! sister chromatid segregation GO:0000819 46 33 1,000 0,01118712 0,07351538 ! nucleus organization GO:0006997 49 33 1,000 0,01118712 0,07330594 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,01118712 0,07309768 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01118712 0,07289061 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,01118712 0,0726847 ! cytokinesis GO:0000910 52 33 1,000 0,01118712 0,07247995 ! ear morphogenesis GO:0042471 42 33 1,000 0,01118712 0,07227636 ! regulation of response to external stimulus GO:0032101 139 96 2,000 0,01145458 0,07379702 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,01145458 0,07359088 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,01184911 0,07591352 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,01184911 0,07570265 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,01184911 0,07549295 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,01184911 0,07528441 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,01184911 0,07507701 ! embryonic organ development GO:0048568 45 34 1,000 0,01184911 0,07487076 ! protein import GO:0017038 156 99 2,000 0,01244469 0,07841858 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,01252791 0,07872733 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,01252791 0,07851281 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 0,01252791 0,07829946 ! Ras protein signal transduction GO:0007265 162 100 2,000 0,0127853 0,0796916 ! protein localization in organelle GO:0033365 161 100 2,000 0,0127853 0,07947621 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01322336 0,08197769 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,01322336 0,08175732 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,01322336 0,08153813 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,01393527 0,08569818 ! amino acid activation GO:0043038 52 37 1,000 0,01393527 0,08546965 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! gliogenesis GO:0042063 71 38 1,000 0,01466347 0,08969678 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,01466347 0,08945886 ! mesenchymal cell development GO:0014031 64 38 1,000 0,01466347 0,08922219 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 0,0154078 0,0935038 ! response to calcium ion GO:0051592 58 40 1,000 0,01616808 0,09785943 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,01616808 0,09760259 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,01616808 0,09734708 ! T cell differentiation GO:0030217 65 40 1,000 0,01616808 0,09709291 ! B cell differentiation GO:0030183 62 40 1,000 0,01616808 0,09684007 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,01616808 0,09658853 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01694414 0,10096252 ! biopolymer methylation GO:0043414 62 41 1,000 0,01694414 0,10070163 ! mitochondrial transport GO:0006839 60 42 1,000 0,01773582 0,10513504 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,01773582 0,10486477 ! cellular component disassembly GO:0022411 64 42 1,000 0,01773582 0,10459588 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,01773582 0,10432837 ! positive regulation of binding GO:0051099 59 43 1,000 0,01854295 0,10879794 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,01854295 0,1085211 ! vesicle organization GO:0016050 79 43 1,000 0,01854295 0,10824566 ! methylation GO:0032259 64 43 1,000 0,01854295 0,10797163 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,01936537 0,11247561 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,01936537 0,1121923 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,0202029 0,11675043 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 0,0202029 0,11645782 ! regulation of ossification GO:0030278 71 46 1,000 0,02105539 0,12106851 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,02192268 0,12574106 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,02192268 0,12542827 ! regulation of muscle contraction GO:0006937 69 48 1,000 0,0228046 0,13015034 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,0228046 0,12982819 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,0228046 0,12950762 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,023701 0,13426677 ! cartilage development GO:0051216 70 49 1,000 0,023701 0,13393687 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02407819 0,13573489 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02407819 0,13540302 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02407819 0,13507277 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02407819 0,13474413 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02407819 0,13441708 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02407819 0,13409161 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02407819 0,13376772 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02407819 0,13344539 ! sleep GO:0030431 11 5 0,000 0,02407819 0,13312461 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02407819 0,13280536 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02407819 0,13248765 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02407819 0,13217145 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02407819 0,13185675 ! tongue development GO:0043586 6 5 0,000 0,02407819 0,13154355 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02407819 0,13123184 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02407819 0,1309216 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02407819 0,13061282 ! cobalt ion transport GO:0006824 9 5 0,000 0,02407819 0,1303055 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02407819 0,12999962 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02407819 0,12969517 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02407819 0,12939214 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02407819 0,12909053 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02407819 0,12879032 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02407819 0,1284915 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02407819 0,12819407 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02407819 0,12789801 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02407819 0,12760331 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02407819 0,12730997 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02407819 0,12701797 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02407819 0,12672731 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02407819 0,12643798 ! malate metabolic process GO:0006108 7 5 0,000 0,02407819 0,12614997 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02407819 0,12586326 ! behavioral response to pain GO:0048266 7 5 0,000 0,02407819 0,12557786 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02407819 0,12529375 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02407819 0,12501092 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02407819 0,12472936 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02407819 0,12444907 ! mating behavior GO:0007617 6 5 0,000 0,02407819 0,12417004 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02407819 0,12389225 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02407819 0,12361571 ! rhythmic behavior GO:0007622 12 5 0,000 0,02407819 0,12334039 ! copulation GO:0007620 7 5 0,000 0,02407819 0,1230663 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02407819 0,12279343 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02407819 0,12252176 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02407819 0,12225129 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02407819 0,12198202 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02407819 0,12171393 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02407819 0,12144701 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02407819 0,12118126 ! response to protozoan GO:0001562 9 5 0,000 0,02407819 0,12091667 ! lymph vessel development GO:0001945 7 5 0,000 0,02407819 0,12065324 ! endochondral ossification GO:0001958 12 5 0,000 0,02407819 0,12039095 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02407819 0,1201298 ! parathyroid gland development GO:0060017 8 5 0,000 0,02407819 0,11986978 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02407819 0,11961088 ! anagen GO:0042640 6 5 0,000 0,02407819 0,1193531 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02407819 0,11909642 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02407819 0,11884085 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02407819 0,11858637 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02407819 0,11833298 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02407819 0,11808067 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02407819 0,11782944 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02407819 0,11757927 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02407819 0,11733016 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02407819 0,11708211 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02407819 0,1168351 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02407819 0,11658913 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02407819 0,11634419 ! ovulation GO:0030728 6 5 0,000 0,02407819 0,11610029 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02407819 0,1158574 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02407819 0,11561553 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,02407819 0,11537466 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02407819 0,1151348 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02407819 0,11489593 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02407819 0,11465805 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02407819 0,11442115 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02407819 0,11418523 ! polyol catabolic process GO:0046174 7 5 0,000 0,02407819 0,11395028 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02407819 0,1137163 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02407819 0,11348327 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02407819 0,1132512 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02407819 0,11302007 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02407819 0,11278989 ! urea metabolic process GO:0019627 6 5 0,000 0,02407819 0,11256064 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02407819 0,11233233 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02407819 0,11210493 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02407819 0,11187846 ! neutrophil activation GO:0042119 5 5 0,000 0,02407819 0,1116529 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02407819 0,11142824 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02407819 0,11120449 ! response to food GO:0032094 5 5 0,000 0,02407819 0,11098164 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02407819 0,11075967 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02407819 0,1105386 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02407819 0,1103184 ! forebrain neuron development GO:0021884 7 5 0,000 0,02407819 0,11009908 ! melanosome organization GO:0032438 7 5 0,000 0,02407819 0,10988063 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02407819 0,10966304 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02407819 0,10944632 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02407819 0,10923045 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02407819 0,10901543 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02407819 0,10880125 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02407819 0,10858791 ! nucleoside transport GO:0015858 6 5 0,000 0,02407819 0,10837541 ! nucleoside salvage GO:0043174 7 5 0,000 0,02407819 0,10816374 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02407819 0,1079529 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02407819 0,10774287 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02407819 0,10753366 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02407819 0,10732526 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02407819 0,10711767 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02407819 0,10691088 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02407819 0,10670489 ! depyrimidination GO:0045008 8 5 0,000 0,02407819 0,10649969 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02407819 0,10629527 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02407819 0,10609164 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02407819 0,10588879 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02407819 0,10568671 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02407819 0,1054854 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02407819 0,10528486 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02407819 0,10508508 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02407819 0,10488605 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02407819 0,10468778 ! monocyte differentiation GO:0030224 8 5 0,000 0,02407819 0,10449026 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02407819 0,10429348 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02407819 0,10409744 ! centrosome duplication GO:0051298 5 5 0,000 0,02407819 0,10390213 ! response to UV-C GO:0010225 6 5 0,000 0,02407819 0,10370756 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02407819 0,10351371 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02407819 0,10332059 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02407819 0,10312819 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02407819 0,1029365 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02407819 0,10274552 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02407819 0,10255525 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02407819 0,10236569 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02407819 0,10217682 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02407819 0,10198865 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02407819 0,10180117 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02407819 0,10161438 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02407819 0,10142827 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02407819 0,10124285 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02407819 0,1010581 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02407819 0,10087402 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02407819 0,10069061 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02407819 0,10050787 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02407819 0,10032579 ! neural tube patterning GO:0021532 6 5 0,000 0,02407819 0,10014437 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02407819 0,0999636 ! histone demethylation GO:0016577 9 5 0,000 0,02407819 0,09978349 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02407819 0,09960402 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02407819 0,0994252 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02407819 0,09924702 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02407819 0,09906948 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02407819 0,09889257 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02407819 0,09871629 ! transcription termination GO:0006353 8 5 0,000 0,02407819 0,09854063 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02407819 0,09836561 ! plasminogen activation GO:0031639 5 5 0,000 0,02407819 0,0981912 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02407819 0,09801741 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02407819 0,09784423 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02407819 0,09767167 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02407819 0,09749971 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02407819 0,09732836 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02407819 0,09715761 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02407819 0,09698745 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02407819 0,0968179 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02407819 0,09664893 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02407819 0,09648055 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02407819 0,09631276 ! glial cell migration GO:0008347 10 5 0,000 0,02407819 0,09614555 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02407819 0,09597892 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02407819 0,09581287 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02407819 0,09564739 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02407819 0,09548248 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02407819 0,09531814 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02407819 0,09515436 ! neural plate development GO:0001840 6 5 0,000 0,02407819 0,09499114 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02407819 0,09482849 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02407819 0,09466639 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02407819 0,09450484 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02407819 0,09434384 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02407819 0,0941834 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02407819 0,09402349 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02407819 0,09386413 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02407819 0,09370531 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02407819 0,09354702 ! spindle assembly GO:0051225 5 5 0,000 0,02407819 0,09338927 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02407819 0,09323205 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02407819 0,09307536 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02407819 0,09291919 ! organ regeneration GO:0031100 7 5 0,000 0,02407819 0,09276355 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02407819 0,09260842 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02407819 0,09245382 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02407819 0,09229973 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02407819 0,09214615 GO:0055081|anion homeostasis, ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,02461172 0,09403149 ! lipid modification GO:0030258 73 50 1,000 0,02461172 0,09387555 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,02461172 0,09372013 ! muscle fiber development GO:0048747 74 51 1,000 0,0255366 0,09708129 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,0255366 0,09692109 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,02647548 0,10031897 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,02742822 0,10375807 ! regulation of mitosis GO:0007088 84 54 1,000 0,02839465 0,10723761 GO:0051783|regulation of nuclear division, ! DNA catabolic process GO:0006308 67 54 1,000 0,02839465 0,10706181 ! detection of external stimulus GO:0009581 66 54 1,000 0,02839465 0,10688659 ! tRNA transcription GO:0009304 11 6 0,000 0,02882462 0,10832782 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02882462 0,1081511 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02882462 0,10797496 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02882462 0,10779939 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02882462 0,10762439 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02882462 0,10744996 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02882462 0,10727609 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,02882462 0,10710279 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02882462 0,10693004 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02882462 0,10675785 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02882462 0,10658621 ! prostate gland development GO:0030850 9 6 0,000 0,02882462 0,10641513 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02882462 0,10624459 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02882462 0,1060746 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02882462 0,10590515 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02882462 0,10573624 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02882462 0,10556787 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02882462 0,10540004 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02882462 0,10523274 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02882462 0,10506597 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02882462 0,10489972 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,02882462 0,104734 ! neuron adhesion GO:0007158 9 6 0,000 0,02882462 0,10456881 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02882462 0,10440413 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02882462 0,10423998 ! signal peptide processing GO:0006465 8 6 0,000 0,02882462 0,10407633 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02882462 0,10391321 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02882462 0,10375059 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02882462 0,10358848 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02882462 0,10342687 ! opsonization GO:0008228 8 6 0,000 0,02882462 0,10326577 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02882462 0,10310517 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02882462 0,10294507 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02882462 0,10278547 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02882462 0,10262635 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02882462 0,10246774 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02882462 0,10230961 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02882462 0,10215196 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02882462 0,10199481 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02882462 0,10183813 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02882462 0,10168194 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02882462 0,10152623 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02882462 0,10137099 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02882462 0,10121622 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02882462 0,10106193 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02882462 0,10090811 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02882462 0,10075475 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02882462 0,10060186 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02882462 0,10044943 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02882462 0,10029747 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02882462 0,10014596 ! thymic T cell selection GO:0045061 12 6 0,000 0,02882462 0,09999491 ! protein lipoylation GO:0009249 10 6 0,000 0,02882462 0,09984431 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02882462 0,09969417 ! pigment granule organization GO:0048753 11 6 0,000 0,02882462 0,09954448 ! drug transport GO:0015893 6 6 0,000 0,02882462 0,09939524 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02882462 0,09924644 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02882462 0,09909809 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02882462 0,09895019 ! histidine metabolic process GO:0006547 6 6 0,000 0,02882462 0,09880272 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02882462 0,09865569 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02882462 0,0985091 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02882462 0,09836295 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02882462 0,09821722 ! adenohypophysis development GO:0021984 10 6 0,000 0,02882462 0,09807193 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02882462 0,09792707 ! hyperosmotic response GO:0006972 8 6 0,000 0,02882462 0,09778263 ! microtubule nucleation GO:0007020 10 6 0,000 0,02882462 0,09763862 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02882462 0,09749504 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02882462 0,09735187 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02882462 0,09720913 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02882462 0,0970668 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02882462 0,09692489 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02882462 0,09678339 ! response to dietary excess GO:0002021 7 6 0,000 0,02882462 0,09664231 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02882462 0,09650164 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02882462 0,09636137 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02882462 0,09622152 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02882462 0,09608207 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02882462 0,09594302 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02882462 0,09580437 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02882462 0,09566613 ! neuron apoptosis GO:0051402 8 6 0,000 0,02882462 0,09552828 ! organic alcohol transport GO:0015850 9 6 0,000 0,02882462 0,09539083 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02882462 0,09525377 ! carnitine transport GO:0015879 8 6 0,000 0,02882462 0,09511711 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02882462 0,09498084 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02882462 0,09484496 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02882462 0,09470946 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02882462 0,09457436 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02882462 0,09443964 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02882462 0,0943053 ! parturition GO:0007567 12 6 0,000 0,02882462 0,09417134 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02882462 0,09403777 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02882462 0,09390457 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02882462 0,09377175 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02882462 0,0936393 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02882462 0,09350723 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02882462 0,09337553 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02882462 0,0932442 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02882462 0,09311324 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02882462 0,09298264 ! astrocyte development GO:0014002 14 6 0,000 0,02882462 0,09285242 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02882462 0,09272255 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02882462 0,09259305 ! interaction with symbiont GO:0051702 8 6 0,000 0,02882462 0,09246391 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02882462 0,09233513 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02882462 0,09220671 ! eating behavior GO:0042755 6 6 0,000 0,02882462 0,09207865 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02882462 0,09195094 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02882462 0,09182358 ! response to copper ion GO:0046688 9 6 0,000 0,02882462 0,09169658 ! DNA topological change GO:0006265 8 6 0,000 0,02882462 0,09156992 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02882462 0,09144362 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02882462 0,09131767 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02882462 0,09119206 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02882462 0,09106679 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02882462 0,09094187 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02882462 0,09081729 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02882462 0,09069306 ! hair follicle maturation GO:0048820 7 6 0,000 0,02882462 0,09056916 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02882462 0,0904456 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02882462 0,09032238 ! Schwann cell development GO:0014044 14 6 0,000 0,02882462 0,09019949 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02882462 0,09007694 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02882462 0,08995472 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02882462 0,08983283 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02882462 0,08971127 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02882462 0,08959003 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02882462 0,08946913 ! histone ubiquitination GO:0016574 7 6 0,000 0,02882462 0,08934855 ! regulation of meiosis GO:0040020 10 6 0,000 0,02882462 0,0892283 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02882462 0,08910837 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02882462 0,08898876 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02882462 0,08886947 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02882462 0,0887505 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02882462 0,08863185 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02882462 0,08851352 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02882462 0,0883955 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02882462 0,0882778 ! receptor internalization GO:0031623 9 6 0,000 0,02882462 0,08816041 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02882462 0,08804333 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02882462 0,08792656 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02882462 0,0878101 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02882462 0,08769395 ! protein deubiquitination GO:0016579 8 6 0,000 0,02882462 0,0875781 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02882462 0,08746257 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02882462 0,08734733 ! axonal fasciculation GO:0007413 9 6 0,000 0,02882462 0,0872324 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02882462 0,08711777 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02882462 0,08700345 ! midbrain development GO:0030901 6 6 0,000 0,02882462 0,08688942 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02882462 0,08677569 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02882462 0,08666226 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02882462 0,08654912 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02882462 0,08643628 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02882462 0,08632373 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02882462 0,08621148 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02882462 0,08609951 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02882462 0,08598784 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02882462 0,08587646 ! adult feeding behavior GO:0008343 6 6 0,000 0,02882462 0,08576536 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02882462 0,08565455 ! blastocyst growth GO:0001832 15 6 0,000 0,02882462 0,08554403 ! pigment granule transport GO:0051904 12 6 0,000 0,02882462 0,0854338 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02882462 0,08532384 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02882462 0,08521417 ! catecholamine transport GO:0051937 7 6 0,000 0,02882462 0,08510478 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02882462 0,08499567 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02882462 0,08488684 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02882462 0,08477829 ! protein prenylation GO:0018342 10 6 0,000 0,02882462 0,08467002 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02882462 0,08456202 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02882462 0,0844543 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02882462 0,08434685 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02882462 0,08423968 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,030368 0,08863758 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,03137462 0,0914596 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 1,000 0,03137462 0,09134383 ! viral reproductive process GO:0022415 87 58 1,000 0,03239433 0,09419338 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,03239433 0,09407445 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03354824 0,09730257 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03354824 0,09718003 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03354824 0,09705779 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03354824 0,09693586 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03354824 0,09681423 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03354824 0,09669291 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03354824 0,09657189 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03354824 0,09645118 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03354824 0,09633076 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03354824 0,09621065 ! reproductive behavior GO:0019098 12 7 0,000 0,03354824 0,09609084 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03354824 0,09597132 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03354824 0,0958521 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,03354824 0,09573318 ! oligopeptide transport GO:0006857 11 7 0,000 0,03354824 0,09561455 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03354824 0,09549621 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03354824 0,09537817 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03354824 0,09526042 ! RNA methylation GO:0001510 11 7 0,000 0,03354824 0,09514296 ! pericardium development GO:0060039 8 7 0,000 0,03354824 0,09502579 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03354824 0,09490891 ! fibril organization GO:0043206 13 7 0,000 0,03354824 0,09479231 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03354824 0,094676 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03354824 0,09455998 ! lipoprotein transport GO:0042953 9 7 0,000 0,03354824 0,09444424 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03354824 0,09432878 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03354824 0,0942136 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03354824 0,09409871 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03354824 0,09398409 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03354824 0,09386976 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03354824 0,0937557 ! chemosensory behavior GO:0007635 9 7 0,000 0,03354824 0,09364192 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03354824 0,09352841 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03354824 0,09341518 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03354824 0,09330223 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03354824 0,09318954 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03354824 0,09307713 ! reflex GO:0060004 12 7 0,000 0,03354824 0,09296499 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03354824 0,09285312 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03354824 0,09274152 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03354824 0,09263018 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03354824 0,09251911 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03354824 0,09240831 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03354824 0,09229778 ! spinal cord patterning GO:0021511 7 7 0,000 0,03354824 0,0921875 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03354824 0,0920775 ! adrenal gland development GO:0030325 17 7 0,000 0,03354824 0,09196775 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03354824 0,09185826 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03354824 0,09174904 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03354824 0,09164007 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03354824 0,09153137 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03354824 0,09142292 ! endosome organization GO:0007032 10 7 0,000 0,03354824 0,09131472 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03354824 0,09120679 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,03354824 0,0910991 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03354824 0,09099168 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03354824 0,0908845 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03354824 0,09077758 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03354824 0,09067091 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03354824 0,09056448 ! galactose metabolic process GO:0006012 10 7 0,000 0,03354824 0,09045831 ! vesicle fusion GO:0006906 15 7 0,000 0,03354824 0,09035239 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03354824 0,09024671 GO:0045851|pH reduction, ! organ growth GO:0035265 11 7 0,000 0,03354824 0,09014129 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03354824 0,0900361 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03354824 0,08993117 ! retinol metabolic process GO:0042572 9 7 0,000 0,03354824 0,08982647 ! behavioral fear response GO:0001662 13 7 0,000 0,03354824 0,08972202 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03354824 0,08961782 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03354824 0,08951385 ! rRNA modification GO:0000154 12 7 0,000 0,03354824 0,08941013 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03354824 0,08930664 ! response to UV-B GO:0010224 11 7 0,000 0,03354824 0,0892034 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03354824 0,08910039 ! intermediate filament organization GO:0045109 11 7 0,000 0,03354824 0,08899763 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03354824 0,08889509 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03354824 0,0887928 ! fibrinolysis GO:0042730 9 7 0,000 0,03354824 0,08869074 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,03354824 0,08858891 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03354824 0,08848732 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03354824 0,08838596 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03354824 0,08828483 ! response to tropane GO:0014073 13 7 0,000 0,03354824 0,08818393 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03354824 0,08808327 ! melanosome localization GO:0032400 10 7 0,000 0,03354824 0,08798283 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03354824 0,08788262 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03354824 0,08778264 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03354824 0,08768289 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03354824 0,08758336 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03354824 0,08748406 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03354824 0,08738498 ! mast cell activation GO:0045576 9 7 0,000 0,03354824 0,08728613 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03354824 0,0871875 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03354824 0,0870891 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,03354824 0,08699091 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03354824 0,08689295 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03354824 0,08679521 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03354824 0,08669769 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03354824 0,08660038 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03354824 0,0865033 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03354824 0,08640643 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03354824 0,08630978 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03354824 0,08621334 ! neuroblast proliferation GO:0007405 13 7 0,000 0,03354824 0,08611712 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03354824 0,08602112 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03354824 0,08592532 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,03354824 0,08582975 ! diuresis GO:0030146 12 7 0,000 0,03354824 0,08573438 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03354824 0,08563922 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,03354824 0,08554428 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03354824 0,08544955 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03354824 0,08535502 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03354824 0,08526071 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03354824 0,0851666 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03354824 0,0850727 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03354824 0,08497901 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03354824 0,08488552 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03354824 0,08479224 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03354824 0,08469917 ! lymph node development GO:0048535 9 7 0,000 0,03354824 0,0846063 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03354824 0,08451363 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03354824 0,08442116 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03354824 0,0843289 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03354824 0,08423684 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03354824 0,08414497 ! ATP catabolic process GO:0006200 10 7 0,000 0,03354824 0,08405331 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03354824 0,08396185 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03354824 0,08387059 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03354824 0,08377952 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03354824 0,08368866 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03354824 0,08359799 ! muscle adaptation GO:0043500 12 7 0,000 0,03354824 0,08350751 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03354824 0,08341723 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03354824 0,08332715 ! retina homeostasis GO:0001895 9 7 0,000 0,03354824 0,08323726 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03354824 0,08314757 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03354824 0,08305806 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03354824 0,08296875 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03354824 0,08287964 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03354824 0,08279071 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03354824 0,08270197 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03354824 0,08261343 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,03447245 0,08479853 ! regulation of heart contraction GO:0008016 91 60 1,000 0,03447245 0,08470794 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,03553056 0,08721482 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,03768417 0,09240256 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,03768417 0,09230415 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,03768417 0,09220595 ! viral reproduction GO:0016032 92 63 1,000 0,03768417 0,09210797 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03824915 0,09338963 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03824915 0,0932906 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,03824915 0,09319177 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03824915 0,09309316 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03824915 0,09299475 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03824915 0,09289655 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03824915 0,09279856 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03824915 0,09270077 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03824915 0,09260319 ! phosphate transport GO:0006817 10 8 0,000 0,03824915 0,09250582 ! N-glycan processing GO:0006491 12 8 0,000 0,03824915 0,09240865 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03824915 0,09231168 ! UTP metabolic process GO:0046051 8 8 0,000 0,03824915 0,09221492 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03824915 0,09211836 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03824915 0,092022 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03824915 0,09192585 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,03824915 0,09182989 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03824915 0,09173413 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03824915 0,09163858 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03824915 0,09154322 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03824915 0,09144806 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03824915 0,0913531 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03824915 0,09125833 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03824915 0,09116377 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03824915 0,09106939 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03824915 0,09097522 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03824915 0,09088123 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03824915 0,09078744 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03824915 0,09069385 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03824915 0,09060045 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03824915 0,09050724 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03824915 0,09041422 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03824915 0,09032139 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03824915 0,09022875 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03824915 0,09013631 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03824915 0,09004405 ! melanin metabolic process GO:0006582 12 8 0,000 0,03824915 0,08995198 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03824915 0,0898601 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03824915 0,0897684 ! macrophage activation GO:0042116 12 8 0,000 0,03824915 0,08967689 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03824915 0,08958557 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03824915 0,08949444 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,03824915 0,08940349 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03824915 0,08931272 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03824915 0,08922214 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03824915 0,08913175 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03824915 0,08904153 ! ruffle organization GO:0031529 11 8 0,000 0,03824915 0,0889515 ! osteoblast development GO:0002076 13 8 0,000 0,03824915 0,08886165 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03824915 0,08877198 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03824915 0,08868249 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03824915 0,08859319 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03824915 0,08850406 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03824915 0,08841511 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03824915 0,08832634 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03824915 0,08823775 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03824915 0,08814933 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03824915 0,08806109 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03824915 0,08797303 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03824915 0,08788515 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03824915 0,08779744 ! segment specification GO:0007379 10 8 0,000 0,03824915 0,0877099 ! cellular extravasation GO:0045123 11 8 0,000 0,03824915 0,08762254 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03824915 0,08753536 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03824915 0,08744834 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03824915 0,0873615 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,03824915 0,08727484 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03824915 0,08718834 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03824915 0,08710201 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03824915 0,08701586 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03824915 0,08692988 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03824915 0,08684406 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03824915 0,08675842 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03824915 0,08667294 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03824915 0,08658763 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03824915 0,08650249 ! icosanoid secretion GO:0032309 12 8 0,000 0,03824915 0,08641752 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,03824915 0,08633271 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03824915 0,08624807 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03824915 0,0861636 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03824915 0,08607929 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03824915 0,08599515 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03824915 0,08591117 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03824915 0,08582735 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03824915 0,0857437 ! sterol catabolic process GO:0016127 9 8 0,000 0,03824915 0,08566021 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03824915 0,08557688 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03824915 0,08549372 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03824915 0,08541071 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03824915 0,08532787 ! prophase GO:0051324 11 8 0,000 0,03824915 0,08524519 ! S phase GO:0051320 8 8 0,000 0,03824915 0,08516267 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03824915 0,0850803 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03824915 0,0849981 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03824915 0,08491606 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03824915 0,08483417 ! hormone catabolic process GO:0042447 13 8 0,000 0,03824915 0,08475244 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03824915 0,08467087 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03824915 0,08458946 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03824915 0,0845082 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03824915 0,0844271 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03824915 0,08434615 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03824915 0,08426536 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03824915 0,08418472 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03824915 0,08410424 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03824915 0,08402391 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03824915 0,08394373 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03824915 0,08386371 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03824915 0,08378384 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03824915 0,08370412 ! adaptive immune response GO:0002250 94 64 1,000 0,03877939 0,08478383 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 1,000 0,03988668 0,08712191 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,04292746 0,09367472 ! telencephalon cell migration GO:0022029 16 9 0,000 0,04292746 0,09358593 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,04292746 0,0934973 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04292746 0,09340885 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04292746 0,09332056 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,04292746 0,09323244 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04292746 0,09314448 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04292746 0,09305669 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,04292746 0,09296907 ! GTP metabolic process GO:0046039 9 9 0,000 0,04292746 0,09288161 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04292746 0,09279432 ! social behavior GO:0035176 14 9 0,000 0,04292746 0,09270718 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,04292746 0,09262022 ! artery development GO:0060840 19 9 0,000 0,04292746 0,09253341 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04292746 0,09244677 ! response to pain GO:0048265 16 9 0,000 0,04292746 0,09236029 ! protein complex disassembly GO:0043241 17 9 0,000 0,04292746 0,09227397 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04292746 0,09218782 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04292746 0,09210182 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,04292746 0,09201598 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04292746 0,09193031 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,04292746 0,09184479 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04292746 0,09175943 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04292746 0,09167424 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04292746 0,09158919 ! protein targeting to ER GO:0045047 19 9 0,000 0,04292746 0,09150431 ! T cell selection GO:0045058 18 9 0,000 0,04292746 0,09141958 ! endoderm development GO:0007492 12 9 0,000 0,04292746 0,09133502 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04292746 0,0912506 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04292746 0,09116634 ! arginine catabolic process GO:0006527 10 9 0,000 0,04292746 0,09108224 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,04292746 0,0909983 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,04292746 0,0909145 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,04292746 0,09083087 ! V(D)J recombination GO:0033151 12 9 0,000 0,04292746 0,09074738 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,04292746 0,09066405 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04292746 0,09058087 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04292746 0,09049785 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04292746 0,09041497 ! mannose metabolic process GO:0006013 9 9 0,000 0,04292746 0,09033225 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04292746 0,09024968 ! receptor clustering GO:0043113 15 9 0,000 0,04292746 0,09016726 ! epithelial cell development GO:0002064 10 9 0,000 0,04292746 0,09008499 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04292746 0,09000287 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04292746 0,0899209 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04292746 0,08983908 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04292746 0,08975741 ! motor axon guidance GO:0008045 14 9 0,000 0,04292746 0,08967589 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,04292746 0,08959451 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,04292746 0,08951328 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,04292746 0,0894322 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,04292746 0,08935127 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04292746 0,08927048 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04292746 0,08918984 ! DNA ligation GO:0006266 14 9 0,000 0,04292746 0,08910934 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04292746 0,08902899 ! response to amine stimulus GO:0014075 13 9 0,000 0,04292746 0,08894878 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04292746 0,08886872 ! erythrocyte development GO:0048821 11 9 0,000 0,04292746 0,08878881 ! renal water homeostasis GO:0003091 14 9 0,000 0,04292746 0,08870903 ! postreplication repair GO:0006301 11 9 0,000 0,04292746 0,0886294 ! mRNA cleavage GO:0006379 13 9 0,000 0,04292746 0,08854991 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04292746 0,08847057 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04292746 0,08839136 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04292746 0,0883123 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,04292746 0,08823338 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04292746 0,0881546 ! acid secretion GO:0046717 14 9 0,000 0,04292746 0,08807596 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04292746 0,08799746 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04292746 0,0879191 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04292746 0,08784088 ! purine base metabolic process GO:0006144 18 9 0,000 0,04292746 0,0877628 ! oocyte differentiation GO:0009994 12 9 0,000 0,04292746 0,08768486 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,04292746 0,08760706 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04292746 0,08752939 ! spleen development GO:0048536 15 9 0,000 0,04292746 0,08745186 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,04292746 0,08737447 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04292746 0,08729722 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04292746 0,0872201 ! detection of calcium ion GO:0005513 13 9 0,000 0,04292746 0,08714312 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04292746 0,08706627 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,04292746 0,08698956 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04292746 0,08691299 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04292746 0,08683654 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04292746 0,08676024 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04292746 0,08668407 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,04292746 0,08660803 ! prepulse inhibition GO:0060134 14 9 0,000 0,04292746 0,08653212 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,04292746 0,08645635 ! insulin secretion GO:0030073 17 9 0,000 0,04292746 0,08638071 ! sequestering of metal ion GO:0051238 11 9 0,000 0,04292746 0,0863052 ! response to nicotine GO:0035094 16 9 0,000 0,04292746 0,08622983 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04292746 0,08615458 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04292746 0,08607947 ! localization within membrane GO:0051668 15 9 0,000 0,04292746 0,08600449 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,04327967 0,08663467 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,0444339 0,0888678 ! response to metal ion GO:0010038 103 70 1,000 0,04559952 0,09111982 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,04559952 0,09104072 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,04677641 0,0933094 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04758328 0,09483669 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04758328 0,09475458 ! neuron fate specification GO:0048665 11 10 0,000 0,04758328 0,09467261 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04758328 0,09459079 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,04758328 0,0945091 ! thyroid gland development GO:0030878 19 10 0,000 0,04758328 0,09442756 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,04758328 0,09434616 ! synapsis GO:0007129 13 10 0,000 0,04758328 0,09426489 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04758328 0,09418377 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,04758328 0,09410279 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04758328 0,09402194 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,04758328 0,09394124 ! sulfate transport GO:0008272 12 10 0,000 0,04758328 0,09386067 ! androgen metabolic process GO:0008209 13 10 0,000 0,04758328 0,09378024 ! phospholipid efflux GO:0033700 16 10 0,000 0,04758328 0,09369995 ! hippocampus development GO:0021766 19 10 0,000 0,04758328 0,09361979 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,04758328 0,09353978 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,04758328 0,0934599 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04758328 0,09338015 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,04758328 0,09330055 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,04758328 0,09322107 ! pathogenesis GO:0009405 13 10 0,000 0,04758328 0,09314174 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04758328 0,09306253 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04758328 0,09298347 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04758328 0,09290453 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,04758328 0,09282573 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04758328 0,09274707 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04758328 0,09266854 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,04758328 0,09259014 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04758328 0,09251187 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04758328 0,09243373 ! B cell proliferation GO:0042100 14 10 0,000 0,04758328 0,09235573 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04758328 0,09227786 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04758328 0,09220012 ! forebrain cell migration GO:0021885 17 10 0,000 0,04758328 0,09212251 ! lipid digestion GO:0044241 15 10 0,000 0,04758328 0,09204503 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04758328 0,09196768 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04758328 0,09189046 ! UV protection GO:0009650 14 10 0,000 0,04758328 0,09181337 ! entry into host cell GO:0030260 20 10 0,000 0,04758328 0,09173641 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,04758328 0,09165958 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04758328 0,09158288 ! negative regulation of ossification GO:0030279 19 10 0,000 0,04758328 0,0915063 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,04758328 0,09142986 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04758328 0,09135354 ! regulation of organ growth GO:0046620 11 10 0,000 0,04758328 0,09127735 ! response to dsRNA GO:0043331 18 10 0,000 0,04758328 0,09120128 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,04758328 0,09112535 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,04758328 0,09104953 ! embryonic axis specification GO:0000578 12 10 0,000 0,04758328 0,09097385 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,04758328 0,09089829 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04758328 0,09082286 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04758328 0,09074755 ! cranial nerve development GO:0021545 12 10 0,000 0,04758328 0,09067236 ! fucose catabolic process GO:0019317 16 10 0,000 0,04758328 0,0905973 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04758328 0,09052237 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04758328 0,09044755 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04758328 0,09037287 ! zymogen activation GO:0031638 14 10 0,000 0,04758328 0,0902983 ! salivary gland development GO:0007431 22 10 0,000 0,04758328 0,09022386 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04758328 0,09014954 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04758328 0,09007534 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04758328 0,09000127 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04758328 0,08992731 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,04758328 0,08985348 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,04758328 0,08977977 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04758328 0,08970618 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04758328 0,08963271 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04758328 0,08955936 ! detection of bacterium GO:0016045 10 10 0,000 0,04758328 0,08948613 ! embryonic gut development GO:0048566 11 10 0,000 0,04758328 0,08941302 ! activation of innate immune response GO:0002218 10 10 0,000 0,04758328 0,08934003 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04758328 0,08926716 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,04758328 0,08919441 ! developmental induction GO:0031128 13 10 0,000 0,04758328 0,08912178 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,04758328 0,08904926 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,04758328 0,08897686 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04758328 0,08890458 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,04758328 0,08883242 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,04796441 0,08947132 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,05037325 0,09388855 ! response to inorganic substance GO:0010035 115 75 1,000 0,05159383 0,09608567 ! rRNA transcription GO:0009303 17 11 0,000 0,05221672 0,09716703 ! respiratory burst GO:0045730 14 11 0,000 0,05221672 0,09708848 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,05221672 0,09701005 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,05221672 0,09693176 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,05221672 0,09685359 ! RNA polyadenylation GO:0043631 19 11 0,000 0,05221672 0,09677554 ! mating GO:0007618 14 11 0,000 0,05221672 0,09669762 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,05221672 0,09661983 ! T cell proliferation GO:0042098 20 11 0,000 0,05221672 0,09654216 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,05221672 0,09646462 ! bone resorption GO:0045453 16 11 0,000 0,05221672 0,0963872 ! regulated secretory pathway GO:0045055 14 11 0,000 0,05221672 0,0963099 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,05221672 0,09623273 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,05221672 0,09615568 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,05221672 0,09607876 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,05221672 0,09600196 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,05221672 0,09592528 ! syncytium formation GO:0006949 15 11 0,000 0,05221672 0,09584872 ! plasma membrane organization GO:0007009 18 11 0,000 0,05221672 0,09577229 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,05221672 0,09569597 ! focal adhesion formation GO:0048041 24 11 0,000 0,05221672 0,09561978 ! mitotic spindle organization GO:0007052 15 11 0,000 0,05221672 0,09554371 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,05221672 0,09546776 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,05221672 0,09539194 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,05221672 0,09531623 ! adult heart development GO:0007512 11 11 0,000 0,05221672 0,09524064 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,05221672 0,09516517 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,05221672 0,09508982 ! temperature homeostasis GO:0001659 16 11 0,000 0,05221672 0,09501459 ! L-glutamate transport GO:0015813 16 11 0,000 0,05221672 0,09493948 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,05221672 0,09486449 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,05221672 0,09478962 ! stem cell development GO:0048864 29 11 0,000 0,05221672 0,09471486 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,05221672 0,09464023 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,05221672 0,09456571 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,05221672 0,0944913 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,05221672 0,09441702 ! vasoconstriction GO:0042310 15 11 0,000 0,05221672 0,09434285 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,05221672 0,0942688 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,05221672 0,09419486 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,05221672 0,09412104 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,05221672 0,09404733 ! ribosome assembly GO:0042255 13 11 0,000 0,05221672 0,09397375 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,05221672 0,09390027 GO:0006809|nitric oxide biosynthetic process, ! chromatin silencing GO:0006342 19 11 0,000 0,05221672 0,09382691 ! nucleosome positioning GO:0016584 13 11 0,000 0,05221672 0,09375367 ! T cell homeostasis GO:0043029 20 11 0,000 0,05221672 0,09368054 ! regulation of isotype switching GO:0045191 19 11 0,000 0,05221672 0,09360752 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,05221672 0,09353462 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,05221672 0,09346183 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,05221672 0,09338915 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,05221672 0,09331659 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,05221672 0,09324414 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,05221672 0,0931718 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,05221672 0,09309957 ! male genitalia development GO:0030539 13 11 0,000 0,05221672 0,09302746 ! cholesterol efflux GO:0033344 19 11 0,000 0,05221672 0,09295545 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,05221672 0,09288356 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,05221672 0,09281178 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,05221672 0,09274011 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,05221672 0,09266855 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,05221672 0,09259711 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,05221672 0,09252577 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,05221672 0,09245454 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,05221672 0,09238342 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,05221672 0,09231241 ! lysogeny GO:0030069 18 11 0,000 0,05221672 0,09224151 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,05221672 0,09217072 ! acrosome reaction GO:0007340 13 11 0,000 0,05221672 0,09210004 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,05221672 0,09202946 ! tRNA metabolic process GO:0006399 95 76 1,000 0,052825 0,09303024 ! response to unfolded protein GO:0006986 99 76 1,000 0,052825 0,09295906 ! gland development GO:0048732 148 77 1,000 0,05406663 0,0950713 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,05406663 0,09499867 ! regulation of DNA binding GO:0051101 119 77 1,000 0,05406663 0,09492615 ! T cell activation GO:0042110 134 79 1,000 0,0565808 0,09926455 ! lactation GO:0007595 20 12 0,000 0,05682788 0,09962204 ! reproductive cellular process GO:0048610 14 12 0,000 0,05682788 0,09954617 ! tRNA modification GO:0006400 14 12 0,000 0,05682788 0,09947041 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,05682788 0,09939476 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,05682788 0,09931924 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,05682788 0,09924382 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,05682788 0,09916852 ! non-recombinational repair GO:0000726 19 12 0,000 0,05682788 0,09909334 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,05682788 0,09901827 ! peroxisomal transport GO:0043574 21 12 0,000 0,05682788 0,09894331 ! cartilage condensation GO:0001502 18 12 0,000 0,05682788 0,09886847 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,05682788 0,09879374 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,05682788 0,09871912 ! palate development GO:0060021 15 12 0,000 0,05682788 0,09864462 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,05682788 0,09857022 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,05682788 0,09849594 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,05682788 0,09842177 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,05682788 0,09834772 ! arginine metabolic process GO:0006525 13 12 0,000 0,05682788 0,09827377 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,05682788 0,09819994 ! methionine metabolic process GO:0006555 13 12 0,000 0,05682788 0,09812621 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,05682788 0,0980526 ! Golgi organization GO:0007030 18 12 0,000 0,05682788 0,0979791 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,05682788 0,0979057 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,05682788 0,09783242 ! monoamine transport GO:0015844 13 12 0,000 0,05682788 0,09775925 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05682788 0,09768618 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,05682788 0,09761323 ! L-amino acid transport GO:0015807 20 12 0,000 0,05682788 0,09754038 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,05682788 0,09746765 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,05682788 0,09739502 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,05682788 0,0973225 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05682788 0,09725009 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,05682788 0,09717778 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,05682788 0,09710558 ! cerebellum development GO:0021549 13 12 0,000 0,05682788 0,09703349 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,05682788 0,09696151 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,05682788 0,09688963 ! histone methylation GO:0016571 15 12 0,000 0,05682788 0,09681786 ! autonomic nervous system development GO:0048483 23 12 0,000 0,05682788 0,0967462 ! gland morphogenesis GO:0022612 23 12 0,000 0,05682788 0,09667464 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,05682788 0,09660319 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,05682788 0,09653184 ! regulation of epidermis development GO:0045682 17 12 0,000 0,05682788 0,0964606 ! intestinal absorption GO:0050892 19 12 0,000 0,05682788 0,09638947 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,05682788 0,09631843 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,05682788 0,09624751 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,05682788 0,09617669 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,05682788 0,09610597 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,05682788 0,09603535 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,05682788 0,09596484 ! response to cold GO:0009409 14 12 0,000 0,05682788 0,09589444 ! mRNA transport GO:0051028 121 81 1,000 0,0591353 0,09971495 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,0591353 0,09964189 ! response to protein stimulus GO:0051789 111 81 1,000 0,0591353 0,09956895 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,0591353 0,09949611 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 1,000 0,06042736 0,10159572 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,06141686 0,10318392 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,06141686 0,10310861 ! cGMP metabolic process GO:0046068 16 13 0,000 0,06141686 0,1030334 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,06141686 0,1029583 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,06141686 0,10288331 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,06141686 0,10280843 ! lipid localization GO:0010876 24 13 0,000 0,06141686 0,10273366 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,06141686 0,102659 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,06141686 0,10258445 ! organelle fusion GO:0048284 28 13 0,000 0,06141686 0,10251001 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,06141686 0,10243567 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,06141686 0,10236144 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,06141686 0,10228732 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,06141686 0,10221331 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,06141686 0,1021394 ! response to hexose stimulus GO:0009746 19 13 0,000 0,06141686 0,1020656 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,06141686 0,10199191 ! glutamate metabolic process GO:0006536 18 13 0,000 0,06141686 0,10191832 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,06141686 0,10184484 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,06141686 0,10177146 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,06141686 0,10169819 ! NAD metabolic process GO:0019674 21 13 0,000 0,06141686 0,10162503 ! exocrine system development GO:0035272 27 13 0,000 0,06141686 0,10155197 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,06141686 0,10147901 ! bone mineralization GO:0030282 15 13 0,000 0,06141686 0,10140617 ! regulation of exocytosis GO:0017157 17 13 0,000 0,06141686 0,10133342 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,06141686 0,10126078 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,06141686 0,10118824 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,06141686 0,10111581 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,06141686 0,10104348 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,06141686 0,10097126 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,06141686 0,10089913 ! genitalia development GO:0048806 15 13 0,000 0,06141686 0,10082712 ! tissue regeneration GO:0042246 21 13 0,000 0,06141686 0,1007552 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,06141686 0,10068338 ! cofactor transport GO:0051181 19 13 0,000 0,06141686 0,10061167 ! NADP metabolic process GO:0006739 18 13 0,000 0,06141686 0,10054006 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,06141686 0,10046856 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,06141686 0,10039715 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,06141686 0,10032584 ! gas transport GO:0015669 18 13 0,000 0,06141686 0,10025464 ! heme biosynthetic process GO:0006783 20 13 0,000 0,06141686 0,10018354 ! regulation of axon extension GO:0030516 23 13 0,000 0,06141686 0,10011254 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,06141686 0,10004164 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,06141686 0,09997083 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,06141686 0,09990013 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,06141686 0,09982953 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,06141686 0,09975903 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,06141686 0,09968863 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,06172914 0,10012485 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,06304051 0,10217983 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,06436135 0,10424725 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,06436135 0,10417389 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,06598379 0,10672483 ! superoxide anion generation GO:0042554 18 14 0,000 0,06598379 0,10664983 ! neuron maturation GO:0042551 21 14 0,000 0,06598379 0,10657494 ! regulation of S phase GO:0033261 18 14 0,000 0,06598379 0,10650015 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,06598379 0,10642546 ! myotube differentiation GO:0014902 21 14 0,000 0,06598379 0,10635088 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,06598379 0,10627641 ! inositol metabolic process GO:0006020 20 14 0,000 0,06598379 0,10620204 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,06598379 0,10612777 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,06598379 0,10605361 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,06598379 0,10597955 ! gene silencing by RNA GO:0031047 20 14 0,000 0,06598379 0,10590559 ! response to cAMP GO:0051591 19 14 0,000 0,06598379 0,10583174 ! limbic system development GO:0021761 25 14 0,000 0,06598379 0,10575799 ! startle response GO:0001964 21 14 0,000 0,06598379 0,10568434 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,06598379 0,10561079 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,06598379 0,10553735 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,06598379 0,10546401 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,06598379 0,10539077 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,06598379 0,10531763 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,06598379 0,1052446 ! glycine metabolic process GO:0006544 22 14 0,000 0,06598379 0,10517166 ! pituitary gland development GO:0021983 23 14 0,000 0,06598379 0,10509883 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,06598379 0,1050261 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,06598379 0,10495346 ! regulation of heart rate GO:0002027 23 14 0,000 0,06598379 0,10488093 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,06598379 0,1048085 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,06598379 0,10473617 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,06598379 0,10466394 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,06598379 0,10459181 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,06598379 0,10451977 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,06598379 0,10444784 ! axon cargo transport GO:0008088 27 14 0,000 0,06598379 0,104376 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,06598379 0,10430427 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,06598379 0,10423263 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,06598379 0,10416109 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,06598379 0,10408965 ! mRNA splice site selection GO:0006376 26 14 0,000 0,06598379 0,10401831 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,06598379 0,10394706 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,06598379 0,10387591 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,06598379 0,10380486 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,06598379 0,10373391 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,06598379 0,10366305 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,06598379 0,10359229 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,06598379 0,10352163 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,06598379 0,10345106 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,06598379 0,10338059 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,06598379 0,10331022 ! cell killing GO:0001906 20 14 0,000 0,06598379 0,10323994 ! cilium assembly GO:0042384 20 14 0,000 0,06598379 0,10316976 ! peptide hormone secretion GO:0030072 23 14 0,000 0,06598379 0,10309967 ! female pregnancy GO:0007565 130 87 1,000 0,06703094 0,10466475 ! establishment of RNA localization GO:0051236 128 88 1,000 0,06837947 0,10669795 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 1,000 0,06837947 0,10662561 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,06973698 0,10866873 ! reproductive developmental process GO:0003006 127 89 1,000 0,06973698 0,10859516 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,07052875 0,1097538 ! positive regulation of cell size GO:0045793 20 15 0,000 0,07052875 0,10967959 ! metencephalon development GO:0022037 19 15 0,000 0,07052875 0,10960549 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,07052875 0,10953148 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,07052875 0,10945757 ! skin development GO:0043588 25 15 0,000 0,07052875 0,10938376 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,07052875 0,10931005 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,07052875 0,10923644 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,07052875 0,10916293 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,07052875 0,10908952 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,07052875 0,10901621 ! bile acid metabolic process GO:0008206 22 15 0,000 0,07052875 0,108943 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,07052875 0,10886988 ! adult walking behavior GO:0007628 25 15 0,000 0,07052875 0,10879686 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,07052875 0,10872394 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,07052875 0,10865112 ! centrosome cycle GO:0007098 16 15 0,000 0,07052875 0,10857839 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,07052875 0,10850577 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,07052875 0,10843324 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,07052875 0,1083608 ! cerebral cortex development GO:0021987 29 15 0,000 0,07052875 0,10828846 ! response to osmotic stress GO:0006970 22 15 0,000 0,07052875 0,10821622 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,07052875 0,10814408 ! DNA integration GO:0015074 22 15 0,000 0,07052875 0,10807203 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,07052875 0,10800008 ! peptide secretion GO:0002790 27 15 0,000 0,07052875 0,10792822 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,07052875 0,10785646 ! regulation of vasodilation GO:0042312 24 15 0,000 0,07052875 0,1077848 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,07052875 0,10771323 ! neuron recognition GO:0008038 22 15 0,000 0,07052875 0,10764175 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,07052875 0,10757037 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,07052875 0,10749909 ! biomineral formation GO:0031214 18 15 0,000 0,07052875 0,10742789 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,07052875 0,1073568 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,07052875 0,10728579 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,07052875 0,10721488 ! dopamine metabolic process GO:0042417 30 15 0,000 0,07052875 0,10714407 ! organic cation transport GO:0015695 19 15 0,000 0,07052875 0,10707335 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,07052875 0,10700272 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,07052875 0,10693218 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,07052875 0,10686174 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,07052875 0,10679139 ! peptide hormone processing GO:0016486 19 15 0,000 0,07052875 0,10672113 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,07052875 0,10665097 ! RNA localization GO:0006403 135 91 1,000 0,07247851 0,10952732 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,0738623 0,11154517 ! cell fate commitment GO:0045165 141 92 1,000 0,0738623 0,11147198 ! DNA recombination GO:0006310 146 92 1,000 0,0738623 0,11139888 ! sulfur metabolic process GO:0006790 118 92 1,000 0,0738623 0,11132588 ! protein secretion GO:0009306 27 16 0,000 0,07505185 0,1130447 ! hormone secretion GO:0046879 25 16 0,000 0,07505185 0,11297072 ! bone remodeling GO:0046849 24 16 0,000 0,07505185 0,11289683 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07505185 0,11282305 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,07505185 0,11274935 ! glial cell development GO:0021782 24 16 0,000 0,07505185 0,11267576 ! patterning of blood vessels GO:0001569 24 16 0,000 0,07505185 0,11260226 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,07505185 0,11252885 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,07505185 0,11245554 ! protein polyubiquitination GO:0000209 26 16 0,000 0,07505185 0,11238233 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,07505185 0,11230921 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,07505185 0,11223619 ! fructose metabolic process GO:0006000 20 16 0,000 0,07505185 0,11216326 ! regulation of protein binding GO:0043393 27 16 0,000 0,07505185 0,11209043 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,07505185 0,11201769 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,07505185 0,11194505 ! protein export from nucleus GO:0006611 24 16 0,000 0,07505185 0,11187249 ! negative regulation of immune response GO:0050777 28 16 0,000 0,07505185 0,11180004 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,07505185 0,11172768 ! DNA replication initiation GO:0006270 25 16 0,000 0,07505185 0,11165541 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,07505185 0,11158323 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,07505185 0,11151115 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,07505185 0,11143916 ! diencephalon development GO:0021536 25 16 0,000 0,07505185 0,11136726 ! oogenesis GO:0048477 23 16 0,000 0,07505185 0,11129546 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,07505185 0,11122375 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,07505185 0,11115213 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,07505185 0,1110806 ! steroid catabolic process GO:0006706 22 16 0,000 0,07505185 0,11100917 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,07505185 0,11093783 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,07505185 0,11086658 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,07505185 0,11079542 ! sperm-egg recognition GO:0035036 16 16 0,000 0,07505185 0,11072435 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,07505185 0,11065337 ! nerve development GO:0021675 18 16 0,000 0,07505185 0,11058249 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,07505185 0,11051169 ! negative regulation of translation GO:0017148 22 16 0,000 0,07505185 0,11044098 ! regulation of binding GO:0051098 151 95 1,000 0,07806439 0,11480058 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,07948162 0,11681005 ! protein maturation GO:0051604 129 96 1,000 0,07948162 0,11673546 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,0795532 0,11676603 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,0795532 0,11669156 ! negative regulation of defense response GO:0031348 19 17 0,000 0,0795532 0,11661719 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,0795532 0,11654291 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,0795532 0,11646872 ! glycerol metabolic process GO:0006071 20 17 0,000 0,0795532 0,11639464 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,0795532 0,11632064 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,0795532 0,11624674 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,0795532 0,11617293 ! signal complex assembly GO:0007172 29 17 0,000 0,0795532 0,11609922 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,0795532 0,1160256 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,0795532 0,11595207 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,0795532 0,11587864 ! memory GO:0007613 25 17 0,000 0,0795532 0,1158053 ! keratinization GO:0031424 17 17 0,000 0,0795532 0,11573205 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,0795532 0,11565889 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,0795532 0,11558583 ! retinoid metabolic process GO:0001523 22 17 0,000 0,0795532 0,11551286 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,0795532 0,11543998 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,0795532 0,11536719 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,0795532 0,1152945 ! vacuolar transport GO:0007034 24 17 0,000 0,0795532 0,11522189 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,0795532 0,11514938 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,0795532 0,11507696 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,0795532 0,11500463 ! heme metabolic process GO:0042168 27 17 0,000 0,0795532 0,11493239 ! actin filament bundle formation GO:0051017 26 17 0,000 0,0795532 0,11486024 ! neuromuscular junction development GO:0007528 23 17 0,000 0,0795532 0,11478818 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,0795532 0,11471622 ! body fluid secretion GO:0007589 27 17 0,000 0,0795532 0,11464434 ! stem cell differentiation GO:0048863 36 17 0,000 0,0795532 0,11457255 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,0795532 0,11450086 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,0795532 0,11442925 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,0795532 0,11435773 ! sensory perception of pain GO:0019233 23 17 0,000 0,0795532 0,1142863 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,0795532 0,11421496 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,0795532 0,11414371 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,0795532 0,11407255 ! synaptogenesis GO:0007416 24 17 0,000 0,0795532 0,11400147 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,0795532 0,11393049 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,0795532 0,11385959 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,0795532 0,11378879 ! cell-cell junction organization GO:0045216 25 17 0,000 0,0795532 0,11371806 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,0795532 0,11364743 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,0795532 0,11357689 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,0795532 0,11350643 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,0795532 0,11343606 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,0795532 0,11336578 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,0840329 0,11967534 ! positive regulation of translation GO:0045727 28 18 0,000 0,0840329 0,11960129 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,0840329 0,11952732 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,0840329 0,11945345 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,0840329 0,11937967 ! cAMP metabolic process GO:0046058 33 18 0,000 0,0840329 0,11930597 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,0840329 0,11923237 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,0840329 0,11915886 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,0840329 0,11908545 ! axis specification GO:0009798 26 18 0,000 0,0840329 0,11901212 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,0840329 0,11893888 GO:0050886|endocrine process, ! pancreas development GO:0031016 26 18 0,000 0,0840329 0,11886573 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,0840329 0,11879267 ! glutamine metabolic process GO:0006541 23 18 0,000 0,0840329 0,1187197 ! response to retinoic acid GO:0032526 25 18 0,000 0,0840329 0,11864683 ! pigmentation during development GO:0048066 31 18 0,000 0,0840329 0,11857404 ! central nervous system neuron development GO:0021954 30 18 0,000 0,0840329 0,11850134 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,0840329 0,11842872 ! fucose metabolic process GO:0006004 26 18 0,000 0,0840329 0,1183562 ! response to fungus GO:0009620 19 18 0,000 0,0840329 0,11828377 ! peptide cross-linking GO:0018149 31 18 0,000 0,0840329 0,11821142 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,0840329 0,11813917 ! heart process GO:0003015 27 18 0,000 0,0840329 0,118067 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,0840329 0,11799492 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,0840329 0,11792293 ! visual learning GO:0008542 35 18 0,000 0,0840329 0,11785102 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,0840329 0,11777921 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,0840329 0,11770748 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,0840329 0,11763584 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,0840329 0,11756428 ! vitamin transport GO:0051180 24 18 0,000 0,0840329 0,11749281 ! hormone transport GO:0009914 27 18 0,000 0,0840329 0,11742143 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,0840329 0,11735014 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,0840329 0,11727893 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,0840329 0,11720781 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,0840329 0,11713677 ! cell-cell recognition GO:0009988 20 18 0,000 0,0840329 0,11706583 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,0840329 0,11699496 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,0840329 0,11692419 ! regulation of glucose import GO:0046324 21 18 0,000 0,0840329 0,11685349 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,0840329 0,11678289 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,0840329 0,11671237 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,08849106 0,12283007 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,08849106 0,12275599 ! positive regulation of ossification GO:0045778 30 19 0,000 0,08849106 0,122682 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,08849106 0,12260809 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,08849106 0,12253428 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,08849106 0,12246055 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,08849106 0,12238691 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,08849106 0,12231336 ! regeneration GO:0031099 32 19 0,000 0,08849106 0,1222399 ! sensory perception of taste GO:0050909 23 19 0,000 0,08849106 0,12216653 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,08849106 0,12209324 ! smooth muscle contraction GO:0006939 36 19 0,000 0,08849106 0,12202004 ! peroxisome organization GO:0007031 29 19 0,000 0,08849106 0,12194693 ! digestive system process GO:0022600 30 19 0,000 0,08849106 0,12187391 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,08849106 0,12180098 ! response to vitamin A GO:0033189 26 19 0,000 0,08849106 0,12172813 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,08849106 0,12165537 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,08849106 0,1215827 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,08849106 0,12151011 ! plasma membrane fusion GO:0045026 23 19 0,000 0,08849106 0,12143761 ! cytolysis GO:0019835 20 19 0,000 0,08849106 0,1213652 ! renal system process GO:0003014 35 19 0,000 0,08849106 0,12129287 ! vasodilation GO:0042311 33 19 0,000 0,08849106 0,12122063 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,08849106 0,12114847 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,08849106 0,1210764 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,08849106 0,12100442 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,08849106 0,12093252 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,08849106 0,12086071 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,08849106 0,12078898 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,08849106 0,12071734 ! sarcomere organization GO:0045214 23 19 0,000 0,08849106 0,12064578 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,08849106 0,12057431 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,08849106 0,12050292 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,08849106 0,12043162 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,08849106 0,1203604 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,08849106 0,12028926 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,08849106 0,12021821 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,08849106 0,12014724 ! protein stabilization GO:0050821 26 19 0,000 0,08849106 0,12007636 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,09292777 0,12602233 ! iron ion transport GO:0006826 37 20 0,000 0,09292777 0,12594806 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,09292777 0,12587389 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,09292777 0,1257998 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,09292777 0,1257258 ! response to vitamin GO:0033273 29 20 0,000 0,09292777 0,12565189 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,09292777 0,12557806 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,09292777 0,12550432 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,09292777 0,12543067 ! spinal cord development GO:0021510 31 20 0,000 0,09292777 0,12535711 ! response to ethanol GO:0045471 37 20 0,000 0,09292777 0,12528363 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,09292777 0,12521023 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,09292777 0,12513692 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,09292777 0,1250637 ! chromosome condensation GO:0030261 31 20 0,000 0,09292777 0,12499056 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,09292777 0,12491751 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,09292777 0,12484455 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,09292777 0,12477167 ! pallium development GO:0021543 38 20 0,000 0,09292777 0,12469887 ! collagen fibril organization GO:0030199 45 20 0,000 0,09292777 0,12462616 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,09292777 0,12455353 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,09292777 0,12448099 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,09292777 0,12440854 ! collagen catabolic process GO:0030574 25 20 0,000 0,09292777 0,12433616 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,09292777 0,12426388 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,09292777 0,12419167 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,09292777 0,12411955 ! alditol metabolic process GO:0019400 24 20 0,000 0,09292777 0,12404751 ! actin filament-based movement GO:0030048 34 20 0,000 0,09292777 0,12397556 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,09734313 0,12979085 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,09734313 0,12971565 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,09734313 0,12964054 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,09734313 0,12956551 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,09734313 0,12949058 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,09734313 0,12941573 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,09734313 0,12934096 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,09734313 0,12926629 ! vesicle docking GO:0048278 27 21 0,000 0,09734313 0,1291917 ! phototransduction GO:0007602 25 21 0,000 0,09734313 0,12911719 ! dendrite development GO:0016358 35 21 0,000 0,09734313 0,12904277 ! visual behavior GO:0007632 39 21 0,000 0,09734313 0,12896844 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,09734313 0,12889419 ! ovarian follicle development GO:0001541 30 21 0,000 0,09734313 0,12882003 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,09734313 0,12874595 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,09734313 0,12867196 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,09734313 0,12859805 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,09734313 0,12852423 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,09734313 0,12845049 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,09734313 0,12837684 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,09734313 0,12830327 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,09734313 0,12822979 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,09734313 0,12815639 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,09734313 0,12808307 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,09734313 0,12800984 ! fatty acid transport GO:0015908 30 21 0,000 0,09734313 0,12793669 ! immunoglobulin production GO:0002377 33 21 0,000 0,09734313 0,12786363 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,09734313 0,12779064 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,09734313 0,12771775 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,09734313 0,12764493 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,09734313 0,1275722 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,09734313 0,12749955 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,09734313 0,12742698 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,09734313 0,1273545 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,09734313 0,1272821 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,09734313 0,12720978 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,09734313 0,12713754 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,09734313 0,12706539 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,09734313 0,12699331 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,09734313 0,12692132 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,10173726 0,13257547 ! viral genome replication GO:0019079 29 22 0,000 0,10173726 0,1325004 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,10173726 0,13242541 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,10173726 0,13235051 ! leukocyte adhesion GO:0007159 38 22 0,000 0,10173726 0,13227569 ! molting cycle process GO:0022404 40 22 0,000 0,10173726 0,13220096 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 0,000 0,10173726 0,13212631 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,10173726 0,13205175 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,10173726 0,13197727 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,10173726 0,13190287 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,10173726 0,13182856 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,10173726 0,13175434 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,10173726 0,13168019 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,10173726 0,13160613 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,10173726 0,13153215 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,10173726 0,13145826 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,10173726 0,13138445 ! membrane depolarization GO:0051899 35 22 0,000 0,10173726 0,13131072 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,10173726 0,13123707 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,10173726 0,13116351 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,10173726 0,13109003 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,10173726 0,13101663 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,10173726 0,13094331 ! neural tube closure GO:0001843 33 22 0,000 0,10173726 0,13087008 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,10173726 0,13079693 ! neuron fate commitment GO:0048663 32 23 0,000 0,10611025 0,13634277 ! embryonic pattern specification GO:0009880 31 23 0,000 0,10611025 0,13626665 ! myelination GO:0042552 35 23 0,000 0,10611025 0,13619061 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,10611025 0,13611465 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,10611025 0,13603878 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,10611025 0,13596299 ! osteoblast differentiation GO:0001649 40 23 0,000 0,10611025 0,13588729 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,10611025 0,13581167 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,10611025 0,13573613 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,10611025 0,13566068 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,10611025 0,13558531 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,10611025 0,13551003 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,10611025 0,13543483 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,10611025 0,13535972 ! cell fate determination GO:0001709 45 23 0,000 0,10611025 0,13528468 ! pentose metabolic process GO:0019321 31 23 0,000 0,10611025 0,13520973 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,10611025 0,13513487 ! spermatid development GO:0007286 33 23 0,000 0,10611025 0,13506008 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,10611025 0,13498538 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,10611025 0,13491076 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,10611025 0,13483622 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,10611025 0,13476177 ! telomere organization GO:0032200 32 23 0,000 0,10611025 0,1346874 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,10611025 0,13461311 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,10611025 0,1345389 ! regulation of amine transport GO:0051952 38 23 0,000 0,10611025 0,13446477 ! liver development GO:0001889 40 23 0,000 0,10611025 0,13439073 ! initiation of viral infection GO:0019059 42 24 0,000 0,11046219 0,13982556 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,11046219 0,13974865 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,11046219 0,13967182 ! superoxide metabolic process GO:0006801 32 24 0,000 0,11046219 0,13959508 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,11046219 0,13951842 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,11046219 0,13944185 ! sperm motility GO:0030317 27 24 0,000 0,11046219 0,13936536 ! vacuole organization GO:0007033 39 24 0,000 0,11046219 0,13928895 ! receptor metabolic process GO:0043112 37 24 0,000 0,11046219 0,13921263 ! primary neural tube formation GO:0014020 35 24 0,000 0,11046219 0,13913639 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,11046219 0,13906023 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,11046219 0,13898416 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,11046219 0,13890817 ! glutathione metabolic process GO:0006749 29 24 0,000 0,11046219 0,13883226 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,11046219 0,13875644 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,11046219 0,1386807 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,1147932 0,14403948 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,1147932 0,14396094 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,1147932 0,14388248 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,1147932 0,14380412 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,1147932 0,14372583 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,1147932 0,14364764 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,1147932 0,14356953 ! peptide transport GO:0015833 43 25 0,000 0,1147932 0,1434915 ! male gonad development GO:0008584 33 25 0,000 0,1147932 0,14341356 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,1147932 0,1433357 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,1147932 0,14325793 ! phospholipid transport GO:0015914 35 25 0,000 0,1147932 0,14318024 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,1147932 0,14310263 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,1147932 0,14302511 ! detection of light stimulus GO:0009583 30 25 0,000 0,1147932 0,14294768 ! leukocyte proliferation GO:0070661 39 25 0,000 0,1147932 0,14287032 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,1147932 0,14279305 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,11910337 0,14807445 ! translational initiation GO:0006413 43 26 0,000 0,11910337 0,14799446 ! circadian rhythm GO:0007623 42 26 0,000 0,11910337 0,14791455 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,11910337 0,14783472 ! post-embryonic development GO:0009791 42 26 0,000 0,11910337 0,14775498 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,11910337 0,14767533 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,11910337 0,14759577 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,11910337 0,14751629 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,11910337 0,14743689 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,11910337 0,14735758 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,11910337 0,14727836 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,11910337 0,14719922 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,11910337 0,14712016 ! regulation of coagulation GO:0050818 39 26 0,000 0,11910337 0,14704119 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,12339279 0,15225505 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,12339279 0,15217342 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,12339279 0,15209187 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,12339279 0,1520104 ! membrane docking GO:0022406 39 27 0,000 0,12339279 0,15192903 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,12339279 0,15184774 ! catechol metabolic process GO:0009712 43 27 0,000 0,12339279 0,15176653 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,12339279 0,15168542 ! acute-phase response GO:0006953 42 27 0,000 0,12339279 0,15160439 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,12339279 0,15152345 ! myofibril assembly GO:0030239 36 27 0,000 0,12339279 0,15144259 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,12339279 0,15136182 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,12339279 0,15128114 ! natural killer cell activation GO:0030101 35 27 0,000 0,12339279 0,15120054 ! lipid oxidation GO:0034440 38 27 0,000 0,12339279 0,15112003 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,12339279 0,15103961 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,12339279 0,15095927 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,12339279 0,15087901 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,12339279 0,15079884 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,12339279 0,15071876 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,12339279 0,15063876 ! gene silencing GO:0016458 41 27 0,000 0,12339279 0,15055884 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,12766157 0,15568485 ! phenol metabolic process GO:0018958 44 28 0,000 0,12766157 0,15560234 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,12766157 0,15551993 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,12766157 0,1554376 ! cell junction assembly GO:0034329 56 28 0,000 0,12766157 0,15535536 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,12766157 0,1552732 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,12766157 0,15519113 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,12766157 0,15510915 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,12766157 0,15502726 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,12766157 0,15494545 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,12766157 0,15486372 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,12766157 0,15478209 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,12766157 0,15470054 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,12766157 0,15461907 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,12766157 0,1545377 ! mesoderm formation GO:0001707 46 28 0,000 0,12766157 0,1544564 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,12766157 0,1543752 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,12766157 0,15429407 ! ensheathment of neurons GO:0007272 43 28 0,000 0,12766157 0,15421304 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,12766157 0,15413208 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,12766157 0,15405122 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,12766157 0,15397044 ! neural tube formation GO:0001841 41 28 0,000 0,12766157 0,15388974 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,13190981 0,15892749 ! regulation of innate immune response GO:0045088 38 29 0,000 0,13190981 0,15884428 ! ovulation cycle process GO:0022602 41 29 0,000 0,13190981 0,15876116 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,13190981 0,15867812 ! protein targeting to membrane GO:0006612 53 29 0,000 0,13190981 0,15859518 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,13190981 0,15851232 ! mismatch repair GO:0006298 34 29 0,000 0,13190981 0,15842954 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,13190981 0,15834685 ! muscle cell development GO:0055001 38 29 0,000 0,13190981 0,15826425 ! formation of primary germ layer GO:0001704 48 29 0,000 0,13190981 0,15818174 ! telencephalon development GO:0021537 52 29 0,000 0,13190981 0,15809931 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,13190981 0,15801696 ! eye morphogenesis GO:0048592 51 29 0,000 0,13190981 0,15793471 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,13190981 0,15785253 ! tissue homeostasis GO:0001894 42 29 0,000 0,13190981 0,15777045 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,13613761 0,16274246 ! organic anion transport GO:0015711 51 30 0,000 0,13613761 0,16265792 ! cholesterol transport GO:0030301 46 30 0,000 0,13613761 0,16257347 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,13613761 0,1624891 ! spliceosome assembly GO:0000245 49 30 0,000 0,13613761 0,16240482 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,13613761 0,16232063 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,13613761 0,16223653 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,13613761 0,16215251 ! ceramide metabolic process GO:0006672 43 30 0,000 0,13613761 0,16206858 ! ovulation cycle GO:0042698 43 30 0,000 0,13613761 0,16198474 ! hindbrain development GO:0030902 45 30 0,000 0,13613761 0,16190098 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,13613761 0,16181731 ! adult locomotory behavior GO:0008344 47 30 0,000 0,13613761 0,16173373 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,13613761 0,16165023 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,13613761 0,16156682 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,13613761 0,16148349 ! response to heat GO:0009408 41 30 0,000 0,13613761 0,16140026 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,13613761 0,1613171 ! negative regulation of secretion GO:0051048 49 31 0,000 0,14034505 0,1662171 ! glial cell differentiation GO:0010001 55 31 0,000 0,14034505 0,16613156 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,14034505 0,1660461 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,14034505 0,16596073 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,14034505 0,16587544 ! odontogenesis GO:0042476 50 31 0,000 0,14034505 0,16579025 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,14034505 0,16570514 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,14034505 0,16562012 ! metanephros development GO:0001656 58 31 0,000 0,14034505 0,16553519 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,14034505 0,16545034 ! cell fate specification GO:0001708 37 31 0,000 0,14034505 0,16536558 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,14034505 0,16528091 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,14034505 0,16519632 ! RNA modification GO:0009451 40 31 0,000 0,14034505 0,16511182 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,14453224 0,169951 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,14453224 0,16986416 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,14453224 0,1697774 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 0,000 0,14453224 0,16969074 ! regulation of protein stability GO:0031647 48 32 0,000 0,14453224 0,16960416 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,14453224 0,16951767 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,14453224 0,16943127 ! cytokine production GO:0001816 44 32 0,000 0,14453224 0,16934496 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,14453224 0,16925873 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,14869928 0,17405004 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,14869928 0,17396151 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,14869928 0,17387307 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,14869928 0,17378472 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,14869928 0,17369646 ! actomyosin structure organization GO:0031032 43 33 0,000 0,14869928 0,17360829 ! cell junction organization GO:0034330 63 33 0,000 0,14869928 0,17352021 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,14869928 0,17343222 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,14869928 0,17334432 ! female gonad development GO:0008585 49 33 0,000 0,14869928 0,1732565 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,14869928 0,17316878 ! positive regulation of cell development GO:0010720 54 33 0,000 0,14869928 0,17308114 ! lipid homeostasis GO:0055088 55 33 0,000 0,14869928 0,17299359 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,14869928 0,17290613 ! regulation of proteolysis GO:0030162 50 33 0,000 0,14869928 0,17281876 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,14869928 0,17273148 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,14869928 0,17264429 ! mRNA catabolic process GO:0006402 48 34 0,000 0,15284625 0,17736951 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,15284625 0,17728007 ! feeding behavior GO:0007631 45 34 0,000 0,15284625 0,17719071 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,15284625 0,17710145 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,15284625 0,17701227 ! neuron migration GO:0001764 46 34 0,000 0,15284625 0,17692319 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,15284625 0,17683419 ! female gamete generation GO:0007292 43 34 0,000 0,15284625 0,17674529 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,15284625 0,17665647 ! polyol metabolic process GO:0019751 44 34 0,000 0,15284625 0,17656774 ! aerobic respiration GO:0009060 47 34 0,000 0,15284625 0,1764791 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,15284625 0,17639056 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,15284625 0,17630209 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,15697326 0,18097168 ! Notch signaling pathway GO:0007219 56 35 0,000 0,15697326 0,18088101 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,15697326 0,18079044 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,15697326 0,18069995 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,15697326 0,18060955 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,15697326 0,18051925 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,15697326 0,18042904 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,15697326 0,18033891 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,15697326 0,18024888 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,15697326 0,18015893 ! glycogen metabolic process GO:0005977 48 35 0,000 0,15697326 0,18006908 ! pigment metabolic process GO:0042440 61 35 0,000 0,15697326 0,17997931 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,1610804 0,18459637 ! negative regulation of binding GO:0051100 58 36 0,000 0,1610804 0,18450444 ! organic ether metabolic process GO:0018904 46 36 0,000 0,1610804 0,1844126 ! neural tube development GO:0021915 50 36 0,000 0,1610804 0,18432086 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,1610804 0,1842292 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,1610804 0,18413763 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,1610804 0,18404616 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,1610804 0,18395478 ! glucan metabolic process GO:0044042 49 36 0,000 0,1610804 0,18386348 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,16516777 0,18843545 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,16516777 0,18834202 ! learning GO:0007612 67 37 0,000 0,16516777 0,18824869 ! ion transmembrane transport GO:0034220 56 37 0,000 0,16516777 0,18815545 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,16516777 0,18806231 ! regulation of protein secretion GO:0050708 51 37 0,000 0,16516777 0,18796925 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,16516777 0,18787629 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,16923545 0,19240807 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,16923545 0,19231301 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,16923545 0,19221804 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,16923545 0,19212317 ! phagocytosis GO:0006909 60 38 0,000 0,16923545 0,19202838 ! maintenance of location in cell GO:0051651 69 38 0,000 0,16923545 0,19193369 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,17328355 0,19642787 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,17328355 0,19633111 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,17328355 0,19623444 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,17328355 0,19613787 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,17328355 0,19604139 ! male sex differentiation GO:0046661 53 39 0,000 0,17328355 0,19594501 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,17328355 0,19584872 ! chromatin remodeling GO:0006338 68 39 0,000 0,17328355 0,19575253 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,17328355 0,19565643 ! JNK cascade GO:0007254 54 39 0,000 0,17328355 0,19556043 ! developmental growth GO:0048589 62 39 0,000 0,17328355 0,19546452 ! cell growth GO:0016049 61 39 0,000 0,17328355 0,1953687 ! synapse organization GO:0050808 55 39 0,000 0,17328355 0,19527298 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,17731215 0,19971495 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,17731215 0,1996172 ! regulation of tube size GO:0035150 60 40 0,000 0,17731215 0,19951954 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,17731215 0,19942197 ! peptide metabolic process GO:0006518 56 40 0,000 0,17731215 0,19932451 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,17731215 0,19922713 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,17731215 0,19912985 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,17731215 0,19903267 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,18132135 0,20343371 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,18132135 0,20333452 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,18132135 0,20323543 ! glucose transport GO:0015758 52 41 0,000 0,18132135 0,20313643 ! endosome transport GO:0016197 71 41 0,000 0,18132135 0,20303754 ! striated muscle contraction GO:0006941 62 41 0,000 0,18132135 0,20293873 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,18132135 0,20284003 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,18132135 0,20274142 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,18132135 0,2026429 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,18531124 0,20700138 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,18531124 0,2069009 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,18531124 0,20680051 ! hexose transport GO:0008645 54 42 0,000 0,18531124 0,20670022 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,18531124 0,20660002 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,18531124 0,20649993 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,18531124 0,20639993 ! excretion GO:0007588 63 42 0,000 0,18531124 0,20630002 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,18531124 0,20620022 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,18531124 0,20610051 ! leukocyte migration GO:0050900 60 43 0,000 0,18928191 0,21041488 ! neuromuscular process GO:0050905 79 43 0,000 0,18928191 0,21031323 ! tRNA processing GO:0008033 49 43 0,000 0,18928191 0,21021168 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,18928191 0,21011023 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,18928191 0,21000887 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,19323346 0,21428976 ! glycolysis GO:0006096 53 44 0,000 0,19323346 0,21418648 ! regulation of action potential GO:0001508 71 44 0,000 0,19323346 0,21408331 ! regulation of ion transport GO:0043269 57 44 0,000 0,19323346 0,21398024 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,19323346 0,21387726 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,19323346 0,21377439 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,19323346 0,21367161 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,19323346 0,21356894 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,19323346 0,21346636 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,19323346 0,21336388 ! RNA catabolic process GO:0006401 64 45 0,000 0,19716597 0,2176016 ! positive regulation of defense response GO:0031349 59 45 0,000 0,19716597 0,21749723 ! regulation of translational initiation GO:0006446 64 45 0,000 0,19716597 0,21739297 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,19716597 0,2172888 ! cell recognition GO:0008037 58 45 0,000 0,19716597 0,21718474 ! cell maturation GO:0048469 60 45 0,000 0,19716597 0,21708077 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,20107954 0,2212837 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,20107954 0,22117788 ! cell redox homeostasis GO:0045454 63 46 0,000 0,20107954 0,22107215 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,20107954 0,22096653 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,20107954 0,220861 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,20497425 0,2250314 ! viral infectious cycle GO:0019058 71 47 0,000 0,20497425 0,22492404 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,20497425 0,22481678 ! endocrine system development GO:0035270 83 47 0,000 0,20497425 0,22470962 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,20497425 0,22460257 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,20497425 0,22449561 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,20497425 0,22438876 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,20497425 0,22428201 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,20497425 0,22417536 ! chloride transport GO:0006821 67 48 0,000 0,2088502 0,22830583 ! response to temperature stimulus GO:0009266 62 48 0,000 0,2088502 0,22819737 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,2088502 0,22808902 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,2088502 0,22798076 ! gastrulation GO:0007369 73 48 0,000 0,2088502 0,22787261 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,2088502 0,22776457 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,2088502 0,22765662 ! regulation of endocytosis GO:0030100 63 48 0,000 0,2088502 0,22754878 ! nuclear export GO:0051168 69 48 0,000 0,2088502 0,22744104 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,2088502 0,2273334 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,21270748 0,23142252 ! sensory perception of smell GO:0007608 61 49 0,000 0,21270748 0,2313131 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,21270748 0,23120378 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,21270748 0,23109457 ! RNA elongation GO:0006354 62 49 0,000 0,21270748 0,23098546 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,21270748 0,23087645 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,21270748 0,23076755 ! germ cell development GO:0007281 68 49 0,000 0,21270748 0,23065875 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,21270748 0,23055005 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,21270748 0,23044145 ! maintenance of location GO:0051235 84 49 0,000 0,21270748 0,23033296 ! regulation of actin filament length GO:0030832 72 50 0,000 0,21654617 0,23437938 ! membrane fusion GO:0006944 80 50 0,000 0,21654617 0,23426914 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,21654617 0,234159 ! proton transport GO:0015992 75 50 0,000 0,21654617 0,23404896 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,21654617 0,23393903 ! positive regulation of secretion GO:0051047 71 51 0,000 0,22036636 0,23795428 ! hydrogen transport GO:0006818 77 51 0,000 0,22036636 0,23784262 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,22036636 0,23773106 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,22036636 0,23761961 ! adult behavior GO:0030534 80 51 0,000 0,22036636 0,23750826 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,22036636 0,23739701 ! transition metal ion transport GO:0000041 74 52 0,000 0,22416814 0,24137955 ! regulation of cellular component size GO:0032535 74 52 0,000 0,22416814 0,2412666 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,22416814 0,24115375 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,22416814 0,24104101 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,2279516 0,24499471 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,2279516 0,24488028 ! kidney development GO:0001822 90 53 0,000 0,2279516 0,24476596 ! single fertilization GO:0007338 59 53 0,000 0,2279516 0,24465174 ! amino acid transport GO:0006865 84 54 0,000 0,23171683 0,24857682 ! glucose catabolic process GO:0006007 66 54 0,000 0,23171683 0,24846093 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,23171683 0,24834515 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,23171683 0,24822948 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,23171683 0,24811392 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,23171683 0,24799846 ! exocytosis GO:0006887 74 55 0,000 0,2354639 0,25189162 ! mesoderm development GO:0007498 76 55 0,000 0,2354639 0,25177451 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,2354639 0,25165752 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,2354639 0,25154063 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,23919292 0,25540563 ! carbohydrate transport GO:0008643 74 57 0,000 0,24290396 0,25924785 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,24290396 0,2591276 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,24290396 0,25900747 ! camera-type eye development GO:0043010 88 57 0,000 0,24290396 0,25888745 ! secondary metabolic process GO:0019748 84 57 0,000 0,24290396 0,25876754 ! developmental maturation GO:0021700 75 57 0,000 0,24290396 0,25864774 ! gonad development GO:0008406 79 57 0,000 0,24290396 0,25852805 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,24659711 0,26233735 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,24659711 0,26221607 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,25027246 0,26600123 ! actin filament organization GO:0007015 95 59 0,000 0,25027246 0,26587836 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,25027246 0,26575561 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,25393009 0,26951509 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,25393009 0,26939078 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,25393009 0,26926657 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,25393009 0,26914249 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,25393009 0,26901852 ! fertilization GO:0009566 68 60 0,000 0,25393009 0,26889466 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,25757008 0,27262365 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,25757008 0,27249824 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,25757008 0,27237296 ! urogenital system development GO:0001655 101 61 0,000 0,25757008 0,27224779 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,25757008 0,27212273 ! extracellular matrix organization GO:0030198 103 61 0,000 0,25757008 0,27199779 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,25757008 0,27187296 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,25757008 0,27174825 ! amine catabolic process GO:0009310 90 62 0,000 0,26119252 0,27544374 ! neurotransmitter transport GO:0006836 81 62 0,000 0,26119252 0,27531751 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,26119252 0,27519139 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,26119252 0,27506538 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,26119252 0,2749395 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,26479749 0,2786067 ! regulation of lipase activity GO:0060191 109 63 0,000 0,26479749 0,2784793 ! appendage morphogenesis GO:0035107 93 64 0,000 0,26838508 0,28212326 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,26838508 0,28199438 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,26838508 0,28186561 ! hexose catabolic process GO:0019320 82 64 0,000 0,26838508 0,28173697 ! reproductive structure development GO:0048608 90 65 0,000 0,27195537 0,28535463 ! appendage development GO:0048736 94 65 0,000 0,27195537 0,28522451 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,27195537 0,28509451 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,27195537 0,28496462 ! defense response to bacterium GO:0042742 73 65 0,000 0,27195537 0,28483486 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,27195537 0,28470521 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,27195537 0,28457568 ! activation of immune response GO:0002253 83 65 0,000 0,27195537 0,28444627 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,27550844 0,28803155 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,27550844 0,28790069 ! antigen processing and presentation GO:0019882 96 66 0,000 0,27550844 0,28776994 ! axon guidance GO:0007411 99 66 0,000 0,27550844 0,28763931 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,27550844 0,28750881 ! regulation of immune effector process GO:0002697 101 66 0,000 0,27550844 0,28737842 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,27904437 0,29093475 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,27904437 0,29080292 ! acute inflammatory response GO:0002526 92 68 0,000 0,28256325 0,29433672 ! learning or memory GO:0007611 123 68 0,000 0,28256325 0,29420347 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,28256325 0,29407035 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,28256325 0,29393734 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,28256325 0,29380446 ! rhythmic process GO:0048511 105 68 0,000 0,28256325 0,2936717 ! inorganic anion transport GO:0015698 93 68 0,000 0,28256325 0,29353905 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,28606515 0,29704282 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,28606515 0,29690877 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,28955016 0,30039033 ! humoral immune response GO:0006959 86 70 0,000 0,28955016 0,3002549 ! eye development GO:0001654 111 70 0,000 0,28955016 0,30011959 ! amine transport GO:0015837 101 70 0,000 0,28955016 0,2999844 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,29301835 0,30344089 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,29301835 0,30330433 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,29301835 0,30316789 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,29301835 0,30303157 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,29301835 0,30289538 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,29646982 0,30632551 ! negative regulation of transport GO:0051051 116 73 0,000 0,29990463 0,30973536 ! regulation of blood pressure GO:0008217 107 73 0,000 0,29990463 0,30959634 ! tube morphogenesis GO:0035239 118 73 0,000 0,29990463 0,30945745 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,29990463 0,30931868 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,29990463 0,30918003 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,30332287 0,31256389 ! digestion GO:0007586 97 74 0,000 0,30332287 0,31242391 ! blood coagulation GO:0007596 116 75 0,000 0,30672461 0,31578631 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 0,000 0,30672461 0,31564501 ! regulation of ligase activity GO:0051340 114 75 0,000 0,30672461 0,31550385 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,30672461 0,31536281 ! amine biosynthetic process GO:0009309 97 76 0,000 0,31010994 0,31870101 ! regulation of protein transport GO:0051223 114 76 0,000 0,31010994 0,31855867 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,31347893 0,32187569 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,31347893 0,32173206 ! sex differentiation GO:0007548 105 77 0,000 0,31347893 0,32158855 ! protein ubiquitination GO:0016567 125 77 0,000 0,31347893 0,32144518 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,31347893 0,32130193 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,31347893 0,32115882 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,31683166 0,32444916 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,31683166 0,32430477 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,32016821 0,32757424 ! cellular respiration GO:0045333 107 79 0,000 0,32016821 0,32742858 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,32016821 0,32728306 ! regulation of lyase activity GO:0051339 133 79 0,000 0,32016821 0,32713767 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,32016821 0,3269924 ! chromatin assembly GO:0031497 102 80 0,000 0,32348866 0,33023698 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,32348866 0,33009047 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,32348866 0,32994408 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,32348866 0,32979783 ! forebrain development GO:0030900 131 80 0,000 0,32348866 0,32965171 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,32679307 0,3328716 ! hemostasis GO:0007599 125 81 0,000 0,32679307 0,33272424 ! regulation of neurological system process GO:0031644 122 81 0,000 0,32679307 0,33257702 ! vitamin metabolic process GO:0006766 103 81 0,000 0,32679307 0,33242993 ! ossification GO:0001503 134 82 0,000 0,33008154 0,33562668 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,33335413 0,33880446 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,33335413 0,33865481 ! regulation of defense response GO:0031347 117 84 0,000 0,33661092 0,34181241 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,33661092 0,34166157 ! sterol metabolic process GO:0016125 120 84 0,000 0,33661092 0,34151086 ! rRNA metabolic process GO:0016072 107 85 0,000 0,33985199 0,34464708 GO:0006364|rRNA processing, ! regulation of protein localization GO:0032880 132 85 0,000 0,33985199 0,34449518 ! regulation of membrane potential GO:0042391 128 85 0,000 0,33985199 0,34434342 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,3430774 0,3474584 ! nucleosome organization GO:0034728 114 87 0,000 0,34628725 0,35055487 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,34628725 0,35040064 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,34628725 0,35024655 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,34628725 0,3500926 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,34948159 0,35316681 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,34948159 0,3530117 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,3526605 0,35606636 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,3526605 0,35591012 ! regulation of T cell activation GO:0050863 128 89 0,000 0,3526605 0,35575402 ! hormone metabolic process GO:0042445 121 90 0,000 0,35582407 0,35878797 ! ATP metabolic process GO:0046034 137 91 0,000 0,35897235 0,36180386 ! response to virus GO:0009615 122 91 0,000 0,35897235 0,36164538 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,36210543 0,36464207 ! positive regulation of immune response GO:0050778 121 92 0,000 0,36210543 0,36448249 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,36522337 0,36746009 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,36522337 0,36729941 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,36522337 0,36713888 ! electron transport chain GO:0022900 123 94 0,000 0,36832625 0,37009628 ! carboxylic acid transport GO:0046942 147 95 0,000 0,37141415 0,37303604 GO:0015849|organic acid transport, ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,37754525 0,3790284 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,38361724 0,38495622 ! extracellular structure organization GO:0043062 156 99 0,000 0,38361724 0,38478834 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,38361724 0,3846206 ! regulation of translation GO:0006417 151 100 0,000 0,38663125 0,38747359 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,38663125 0,38730483 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,38663125 0,38713621 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,38663125 0,38696775 ! divalent metal ion transport GO:0070838 171 100 0,000 0,38663125 0,38679943 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,38663125 0,38663125