pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/532-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of lipid kinase activity GO:0043550 17 8 5,000 5,929E-14 1,448E-10 ! lung development GO:0030324 165 69 7,000 1,785E-10 2,181E-07 ! respiratory tube development GO:0030323 171 72 7,000 2,532E-10 2,062E-07 ! respiratory system development GO:0060541 175 74 7,000 3,169E-10 1,936E-07 ! positive regulation of pseudopodium assembly GO:0031274 15 6 3,000 2,548E-09 1,245E-06 GO:0031272|regulation of pseudopodium assembly, ! interphase of mitotic cell cycle GO:0051329 224 98 7,000 3,075E-09 1,252E-06 ! auditory receptor cell differentiation GO:0042491 36 17 4,000 3,618E-09 1,263E-06 ! trophectodermal cell differentiation GO:0001829 13 8 3,000 1,182E-08 3,61E-06 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 4,000 1,517E-08 4,119E-06 ! inner ear receptor cell differentiation GO:0060113 42 22 4,000 1,517E-08 3,707E-06 ! induction of apoptosis by intracellular signals GO:0008629 95 45 5,000 1,544E-08 3,429E-06 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 1,77E-08 3,604E-06 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 3,000 2,122E-08 3,988E-06 ! mechanoreceptor differentiation GO:0042490 48 24 4,000 2,435E-08 4,248E-06 ! blastocyst formation GO:0001825 18 10 3,000 3,527E-08 5,744E-06 ! positive regulation of cell migration GO:0030335 137 58 5,000 7,38E-08 1,127E-05 ! regulation of cell projection assembly GO:0060491 33 12 3,000 8,266E-08 1,188E-05 ! positive regulation of cell motion GO:0051272 157 65 5,000 1,475E-07 2,002E-05 ! ear development GO:0043583 114 66 5,000 1,617E-07 2,08E-05 ! regulation of lipid metabolic process GO:0019216 132 66 5,000 1,617E-07 1,976E-05 ! positive regulation of glycolysis GO:0045821 13 5 2,000 4,755E-07 5,532E-05 ! regulation of gene-specific transcription GO:0032583 102 46 4,000 7,361E-07 8,175E-05 ! nuclear migration GO:0007097 13 6 2,000 9,485E-07 1,007E-04 ! G1 phase GO:0051318 44 22 3,000 1,187E-06 1,209E-04 ! inner ear development GO:0048839 89 53 4,000 1,51E-06 1,475E-04 ! regulation of DNA metabolic process GO:0051052 188 97 5,000 1,604E-06 1,507E-04 ! blastocyst development GO:0001824 50 26 3,000 2,399E-06 2,171E-04 ! establishment of organelle localization GO:0051656 122 59 4,000 2,588E-06 2,258E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 2,641E-06 2,225E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 2,641E-06 2,151E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 2,641E-06 2,082E-04 ! positive regulation of cell projection organization GO:0031346 66 27 3,000 2,809E-06 2,144E-04 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 2,809E-06 2,079E-04 ! regulation of fibroblast proliferation GO:0048145 56 28 3,000 3,267E-06 2,348E-04 ! regulation of homeostatic process GO:0032844 148 62 4,000 3,316E-06 2,315E-04 ! positive regulation of glucose metabolic process GO:0010907 18 9 2,000 3,952E-06 2,682E-04 ! regulation of glycolysis GO:0006110 20 9 2,000 3,952E-06 2,609E-04 ! macrophage differentiation GO:0030225 15 9 2,000 3,952E-06 2,54E-04 ! regulation of developmental growth GO:0048638 16 10 2,000 5,63E-06 3,527E-04 ! lung alveolus development GO:0048286 26 10 2,000 5,63E-06 3,439E-04 ! protein sumoylation GO:0016925 17 10 2,000 5,63E-06 3,355E-04 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 2,000 5,63E-06 3,275E-04 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 5,63E-06 3,199E-04 ! positive regulation of gene-specific transcription GO:0043193 70 33 3,000 6,438E-06 3,575E-04 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 2,000 7,721E-06 4,191E-04 ! nucleus localization GO:0051647 22 11 2,000 7,721E-06 4,1E-04 ! organelle localization GO:0051640 155 74 4,000 7,971E-06 4,143E-04 ! positive regulation of cellular catabolic process GO:0031331 34 12 2,000 1,027E-05 5,225E-04 ! embryonic placenta development GO:0001892 21 12 2,000 1,027E-05 5,119E-04 ! cellular response to insulin stimulus GO:0032869 85 38 3,000 1,145E-05 5,595E-04 ! response to hypoxia GO:0001666 178 81 4,000 1,242E-05 5,95E-04 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 2,000 1,331E-05 6,253E-04 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of erythrocyte differentiation GO:0045646 47 13 2,000 1,331E-05 6,135E-04 ! response to oxygen levels GO:0070482 183 83 4,000 1,399E-05 6,331E-04 ! negative regulation of growth GO:0045926 168 85 4,000 1,572E-05 6,981E-04 ! cellular response to hormone stimulus GO:0032870 182 85 4,000 1,572E-05 6,856E-04 ! release of cytochrome c from mitochondria GO:0001836 31 14 2,000 1,69E-05 7,241E-04 ! regulation of myeloid cell differentiation GO:0045637 105 43 3,000 1,887E-05 7,95E-04 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 2,000 2,106E-05 8,721E-04 ! muscle maintenance GO:0046716 26 15 2,000 2,106E-05 8,576E-04 ! regulation of glucose metabolic process GO:0010906 28 16 2,000 2,585E-05 1,035E-03 ! response to insulin stimulus GO:0032868 98 47 3,000 2,697E-05 1,063E-03 ! filopodium assembly GO:0046847 42 17 2,000 3,131E-05 1,214E-03 ! regulation of muscle cell differentiation GO:0051147 36 17 2,000 3,131E-05 1,195E-03 ! regulation of cell projection organization GO:0031344 135 51 3,000 3,737E-05 1,404E-03 ! heart looping GO:0001947 34 18 2,000 3,747E-05 1,387E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 2,000 3,747E-05 1,366E-03 ! microspike assembly GO:0030035 46 18 2,000 3,747E-05 1,346E-03 ! positive regulation of growth GO:0045927 96 53 3,000 4,354E-05 1,541E-03 ! G1 phase of mitotic cell cycle GO:0000080 39 19 2,000 4,438E-05 1,549E-03 ! regulation of cell shape GO:0008360 142 54 3,000 4,689E-05 1,613E-03 ! response to UV GO:0009411 120 55 3,000 5,042E-05 1,711E-03 ! regulation of carbohydrate metabolic process GO:0006109 37 20 2,000 5,207E-05 1,743E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 5,207E-05 1,719E-03 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 2,000 5,207E-05 1,696E-03 ! regulation of DNA replication GO:0006275 105 56 3,000 5,415E-05 1,741E-03 ! heart morphogenesis GO:0003007 105 57 3,000 5,807E-05 1,842E-03 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 2,000 8,025E-05 2,513E-03 ! regulation of cellular catabolic process GO:0031329 55 24 2,000 9,147E-05 2,828E-03 ! response to peptide hormone stimulus GO:0043434 129 64 3,000 9,158E-05 2,797E-03 ! positive regulation of fibroblast proliferation GO:0048146 48 25 2,000 1,037E-04 3,126E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 1,037E-04 3,088E-03 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 2,000 1,037E-04 3,051E-03 ! vasculogenesis GO:0001570 49 25 2,000 1,037E-04 3,015E-03 ! interaction with host GO:0051701 66 25 2,000 1,037E-04 2,979E-03 ! protein tetramerization GO:0051262 57 25 2,000 1,037E-04 2,945E-03 ! negative regulation of cell growth GO:0030308 142 67 3,000 1,095E-04 3,076E-03 ! myeloid cell differentiation GO:0030099 126 67 3,000 1,095E-04 3,041E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 1,169E-04 3,208E-03 ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 1,169E-04 3,172E-03 ! negative regulation of cell size GO:0045792 144 69 3,000 1,229E-04 3,298E-03 ! regulation of endothelial cell proliferation GO:0001936 60 27 2,000 1,311E-04 3,482E-03 ! cellular response to oxidative stress GO:0034599 43 27 2,000 1,311E-04 3,445E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 1,311E-04 3,408E-03 ! hemoglobin biosynthetic process GO:0042541 8 5 1,000 1,318E-04 3,389E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 1,318E-04 3,354E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 1,318E-04 3,319E-03 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 1,318E-04 3,285E-03 ! positive regulation of muscle cell differentiation GO:0051149 13 5 1,000 1,318E-04 3,252E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 1,318E-04 3,22E-03 ! valine metabolic process GO:0006573 12 5 1,000 1,318E-04 3,188E-03 ! mRNA transcription GO:0009299 10 5 1,000 1,318E-04 3,156E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 1,318E-04 3,126E-03 ! decidualization GO:0046697 11 5 1,000 1,318E-04 3,096E-03 ! mitotic recombination GO:0006312 9 5 1,000 1,318E-04 3,066E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 1,318E-04 3,037E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 1,318E-04 3,009E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 1,465E-04 3,313E-03 ! cellular iron ion homeostasis GO:0006879 57 29 2,000 1,629E-04 3,652E-03 ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 1,629E-04 3,619E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 1,806E-04 3,974E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 1,972E-04 4,302E-03 ! embryonic hemopoiesis GO:0035162 16 6 1,000 1,972E-04 4,264E-03 ! regulation of smooth muscle cell differentiation GO:0051150 12 6 1,000 1,972E-04 4,226E-03 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 1,000 1,972E-04 4,189E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 1,972E-04 4,153E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 1,972E-04 4,118E-03 GO:0051653|spindle localization, ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 1,972E-04 4,083E-03 ! oxygen homeostasis GO:0032364 10 6 1,000 1,972E-04 4,049E-03 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 1,972E-04 4,015E-03 ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 1,972E-04 3,982E-03 ! maternal placenta development GO:0001893 12 6 1,000 1,972E-04 3,949E-03 ! iron ion homeostasis GO:0055072 60 31 2,000 1,994E-04 3,96E-03 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 1,994E-04 3,928E-03 ! protein oligomerization GO:0051259 149 79 3,000 2,076E-04 4,057E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 2,194E-04 4,254E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 2,633E-04 5,065E-03 ! regulation of helicase activity GO:0051095 16 7 1,000 2,754E-04 5,257E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 2,754E-04 5,216E-03 ! mRNA stabilization GO:0048255 18 7 1,000 2,754E-04 5,176E-03 GO:0043489|RNA stabilization, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 2,754E-04 5,136E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 2,754E-04 5,098E-03 ! male sex determination GO:0030238 15 7 1,000 2,754E-04 5,059E-03 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 2,754E-04 5,022E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 2,754E-04 4,984E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 2,754E-04 4,948E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 2,754E-04 4,912E-03 ! placenta development GO:0001890 53 35 2,000 2,872E-04 5,084E-03 ! tissue remodeling GO:0048771 78 37 2,000 3,391E-04 5,961E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 3,664E-04 6,393E-03 ! succinate metabolic process GO:0006105 17 8 1,000 3,664E-04 6,348E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 3,664E-04 6,303E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 3,664E-04 6,259E-03 ! hemoglobin metabolic process GO:0020027 14 8 1,000 3,664E-04 6,215E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 3,664E-04 6,173E-03 ! ER overload response GO:0006983 13 8 1,000 3,664E-04 6,13E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 3,664E-04 6,089E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 3,664E-04 6,047E-03 ! gas homeostasis GO:0033483 14 8 1,000 3,664E-04 6,007E-03 ! response to tumor cell GO:0002347 16 8 1,000 3,664E-04 5,967E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 3,664E-04 5,927E-03 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 1,000 3,664E-04 5,888E-03 ! positive regulation of smooth muscle contraction GO:0045987 15 8 1,000 3,664E-04 5,85E-03 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 3,672E-04 5,826E-03 ! meiosis I GO:0007127 74 38 2,000 3,672E-04 5,788E-03 ! regulation of cell morphogenesis GO:0022604 243 93 3,000 3,878E-04 6,073E-03 ! carbohydrate homeostasis GO:0033500 59 39 2,000 3,968E-04 6,174E-03 GO:0042593|glucose homeostasis, ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 4,603E-04 7,118E-03 ! multicellular organismal metabolic process GO:0044236 64 41 2,000 4,603E-04 7,073E-03 ! induction of positive chemotaxis GO:0050930 17 9 1,000 4,699E-04 7,175E-03 ! middle ear morphogenesis GO:0042474 14 9 1,000 4,699E-04 7,13E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 1,000 4,699E-04 7,086E-03 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 4,699E-04 7,043E-03 ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 1,000 4,699E-04 7E-03 ! regulation of macrophage differentiation GO:0045649 16 9 1,000 4,699E-04 6,957E-03 ! regulation of telomere maintenance GO:0032204 17 9 1,000 4,699E-04 6,916E-03 ! leukocyte differentiation GO:0002521 232 98 3,000 4,731E-04 6,92E-03 ! double-strand break repair GO:0006302 85 44 2,000 5,674E-04 8,251E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 5,86E-04 8,471E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 5,86E-04 8,421E-03 ! COPI coating of Golgi vesicle GO:0048205 23 10 1,000 5,86E-04 8,372E-03 GO:0048200|Golgi transport vesicle coating, ! regulation of mesenchymal cell proliferation GO:0010464 36 10 1,000 5,86E-04 8,323E-03 ! phosphagen metabolic process GO:0006599 17 10 1,000 5,86E-04 8,275E-03 GO:0006600|creatine metabolic process, ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 1,000 5,86E-04 8,227E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 5,86E-04 8,18E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 5,86E-04 8,134E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 5,86E-04 8,088E-03 ! pigmentation GO:0043473 103 46 2,000 6,469E-04 8,878E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 7,145E-04 9,751E-03 ! Golgi vesicle budding GO:0048194 26 11 1,000 7,145E-04 9,697E-03 ! detection of mechanical stimulus GO:0050982 22 11 1,000 7,145E-04 9,644E-03 ! blood vessel remodeling GO:0001974 30 11 1,000 7,145E-04 9,591E-03 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 7,145E-04 9,538E-03 ! regulation of intracellular pH GO:0051453 21 11 1,000 7,145E-04 9,486E-03 ! positive regulation of muscle contraction GO:0045933 19 11 1,000 7,145E-04 9,435E-03 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 7,145E-04 9,384E-03 ! DNA methylation GO:0006306 19 11 1,000 7,145E-04 9,334E-03 GO:0006305|DNA alkylation, ! apical protein localization GO:0045176 18 11 1,000 7,145E-04 9,284E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 1,000 7,145E-04 9,235E-03 ! regulation of embryonic development GO:0045995 35 11 1,000 7,145E-04 9,187E-03 ! positive regulation of cell cycle GO:0045787 96 48 2,000 7,331E-04 9,377E-03 ! activation of caspase activity GO:0006919 95 50 2,000 8,263E-04 0,01051434 ! virus-host interaction GO:0019048 30 12 1,000 8,553E-04 0,01082671 ! regulation of B cell proliferation GO:0030888 22 12 1,000 8,553E-04 0,0107709 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 8,553E-04 0,01071566 GO:0050927|positive regulation of positive chemotaxis, ! entry into host cell GO:0030260 34 12 1,000 8,553E-04 0,01066099 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 8,553E-04 0,01060688 ! regulation of hormone metabolic process GO:0032350 28 12 1,000 8,553E-04 0,01055331 ! peptidyl-lysine modification GO:0018205 21 12 1,000 8,553E-04 0,01050027 ! regulation of leukocyte migration GO:0002685 29 12 1,000 8,553E-04 0,01044777 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 8,553E-04 0,01039579 ! histone modification GO:0016570 104 52 2,000 9,268E-04 0,01120869 ! regulation of chemokine production GO:0032642 18 13 1,000 1,008E-03 0,01213577 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 1,008E-03 0,01207628 GO:0000725|recombinational repair, ! response to X-ray GO:0010165 28 13 1,000 1,008E-03 0,01201737 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 1,008E-03 0,01195903 ! asymmetric protein localization GO:0008105 24 13 1,000 1,008E-03 0,01190126 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 1,008E-03 0,01184404 ! regulation of mRNA stability GO:0043488 32 13 1,000 1,008E-03 0,01178737 ! covalent chromatin modification GO:0016569 115 54 2,000 1,035E-03 0,0120366 ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 1,000 1,174E-03 0,01358898 ! regulation of cellular pH GO:0030641 27 14 1,000 1,174E-03 0,01352488 ! response to gamma radiation GO:0010332 30 14 1,000 1,174E-03 0,01346139 ! regulation of RNA stability GO:0043487 33 14 1,000 1,174E-03 0,01339848 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 1,211E-03 0,01375846 ! regulation of bone remodeling GO:0046850 143 57 2,000 1,211E-03 0,01369476 ! positive regulation of caspase activity GO:0043280 108 57 2,000 1,211E-03 0,01363165 GO:0010952|positive regulation of peptidase activity, ! aging GO:0007568 112 58 2,000 1,273E-03 0,01427124 ! regulation of tissue remodeling GO:0034103 146 58 2,000 1,273E-03 0,01420608 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 1,351E-03 0,01500217 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 1,351E-03 0,01493429 ! vesicle coating GO:0006901 38 15 1,000 1,351E-03 0,01486702 ! G1/S transition checkpoint GO:0031575 37 15 1,000 1,351E-03 0,01480035 ! histone deacetylation GO:0016575 24 15 1,000 1,351E-03 0,01473428 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 1,351E-03 0,01466879 ! epithelial to mesenchymal transition GO:0001837 30 15 1,000 1,351E-03 0,01460389 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 1,54E-03 0,01657688 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 1,54E-03 0,01650417 ! viral reproductive process GO:0022415 132 62 2,000 1,544E-03 0,01647574 ! regulation of protein complex assembly GO:0043254 132 63 2,000 1,617E-03 0,01717859 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 1,741E-03 0,01841766 ! endothelial cell migration GO:0043542 31 17 1,000 1,741E-03 0,01833828 ! myoblast differentiation GO:0045445 50 17 1,000 1,741E-03 0,01825957 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 1,741E-03 0,01818154 ! regulation of survival gene product expression GO:0045884 38 17 1,000 1,741E-03 0,01810417 ! membrane budding GO:0006900 42 17 1,000 1,741E-03 0,01802746 ! DNA unwinding during replication GO:0006268 26 17 1,000 1,741E-03 0,01795139 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 1,741E-03 0,01787597 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 1,741E-03 0,01780117 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 1,741E-03 0,017727 ! activation of MAPK activity GO:0000187 124 67 2,000 1,93E-03 0,01956827 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 1,955E-03 0,01973077 ! neural crest cell migration GO:0001755 41 18 1,000 1,955E-03 0,01964958 ! viral reproduction GO:0016032 142 68 2,000 2,014E-03 0,02016609 ! cell projection assembly GO:0030031 138 68 2,000 2,014E-03 0,02008378 ! negative regulation of protein kinase activity GO:0006469 144 69 2,000 2,1E-03 0,02085587 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 2,179E-03 0,021554 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 2,179E-03 0,02146709 ! cellular pigmentation GO:0033059 37 19 1,000 2,179E-03 0,02138088 ! negative regulation of kinase activity GO:0033673 145 70 2,000 2,188E-03 0,02138423 ! cell cycle checkpoint GO:0000075 145 71 2,000 2,279E-03 0,02217974 ! positive regulation of angiogenesis GO:0045766 50 20 1,000 2,416E-03 0,02341763 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 2,416E-03 0,02332507 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 1,000 2,416E-03 0,02323323 ! protein amino acid deacetylation GO:0006476 34 20 1,000 2,416E-03 0,02314212 ! protein amino acid acetylation GO:0006473 41 20 1,000 2,416E-03 0,02305172 ! response to alkaloid GO:0043279 38 20 1,000 2,416E-03 0,02296203 ! DNA duplex unwinding GO:0032508 30 20 1,000 2,416E-03 0,02287303 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 1,000 2,416E-03 0,02278472 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of caspase activity GO:0043281 136 74 2,000 2,564E-03 0,02409245 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 2,564E-03 0,02400014 ! negative regulation of transferase activity GO:0051348 155 74 2,000 2,564E-03 0,02390853 ! lipid phosphorylation GO:0046834 43 21 1,000 2,663E-03 0,02474085 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 2,663E-03 0,02464714 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 2,663E-03 0,02455413 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 2,663E-03 0,02446182 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 2,87E-03 0,02626429 ! regulation of catabolic process GO:0009894 173 77 2,000 2,87E-03 0,02616629 ! reciprocal meiotic recombination GO:0007131 44 22 1,000 2,923E-03 0,02654437 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 2,923E-03 0,02644606 ! cellular response to starvation GO:0009267 37 22 1,000 2,923E-03 0,02634847 ! apoptotic nuclear changes GO:0030262 34 22 1,000 2,923E-03 0,0262516 ! cell aging GO:0007569 48 22 1,000 2,923E-03 0,02615544 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 2,923E-03 0,02605999 ! positive regulation of locomotion GO:0040017 44 22 1,000 2,923E-03 0,02596522 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of B cell activation GO:0050871 42 22 1,000 2,923E-03 0,02587114 ! response to cytokine stimulus GO:0034097 69 22 1,000 2,923E-03 0,02577775 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 2,923E-03 0,02568502 ! positive regulation of DNA replication GO:0045740 44 23 1,000 3,194E-03 0,02796347 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 3,194E-03 0,0278636 ! regulation of chemotaxis GO:0050920 45 23 1,000 3,194E-03 0,02776444 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 3,194E-03 0,02766598 GO:0010810|regulation of cell-substrate adhesion, ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 3,194E-03 0,02756822 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 3,194E-03 0,02747115 ! vesicle targeting GO:0006903 49 23 1,000 3,194E-03 0,02737476 ! DNA modification GO:0006304 36 23 1,000 3,194E-03 0,02727905 ! meiosis GO:0007126 143 81 2,000 3,313E-03 0,02819853 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 2,000 3,313E-03 0,02810062 ! positive regulation of phosphorylation GO:0042327 149 81 2,000 3,313E-03 0,02800339 ! regulation of peptidase activity GO:0052547 150 82 2,000 3,429E-03 0,02888993 ! protein import into nucleus GO:0006606 174 82 2,000 3,429E-03 0,02879065 ! meiotic cell cycle GO:0051321 144 82 2,000 3,429E-03 0,02869205 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 3,476E-03 0,02897866 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 3,476E-03 0,0288801 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 3,476E-03 0,0287822 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 3,476E-03 0,02868496 ! sex determination GO:0007530 48 24 1,000 3,476E-03 0,02858838 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 3,476E-03 0,02849244 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 3,476E-03 0,02839715 ! response to drug GO:0042493 149 83 2,000 3,549E-03 0,02889753 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 2,000 3,549E-03 0,02880152 GO:0045937|positive regulation of phosphate metabolic process, ! nuclear import GO:0051170 177 83 2,000 3,549E-03 0,02870615 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 3,769E-03 0,03038632 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 3,769E-03 0,03028636 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 3,769E-03 0,03018706 ! negative regulation of DNA replication GO:0008156 45 25 1,000 3,769E-03 0,03008841 ! regulation of behavior GO:0050795 48 25 1,000 3,769E-03 0,0299904 ! mitochondrion organization GO:0007005 159 87 2,000 4,051E-03 0,03212851 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 4,073E-03 0,03220232 ! initiation of viral infection GO:0019059 60 26 1,000 4,073E-03 0,03209844 ! regulation of smooth muscle contraction GO:0006940 48 26 1,000 4,073E-03 0,03199523 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 4,073E-03 0,03189268 GO:0045936|negative regulation of phosphate metabolic process, ! neural crest cell development GO:0014032 59 26 1,000 4,073E-03 0,03179078 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 83 26 1,000 4,073E-03 0,03168954 GO:0050768|negative regulation of neurogenesis, ! positive regulation of nuclear division GO:0051785 41 26 1,000 4,073E-03 0,03158894 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 4,073E-03 0,03148897 ! protein localization in nucleus GO:0034504 192 89 2,000 4,317E-03 0,03326889 ! mitochondrial membrane organization GO:0007006 60 27 1,000 4,388E-03 0,03371362 ! response to starvation GO:0042594 47 27 1,000 4,388E-03 0,03360793 ! response to toxin GO:0009636 49 27 1,000 4,388E-03 0,03350291 ! cellular response to nutrient levels GO:0031669 45 27 1,000 4,388E-03 0,03339854 ! positive regulation of protein modification process GO:0031401 156 90 2,000 4,454E-03 0,03379214 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 4,715E-03 0,03565973 ! protein amino acid acylation GO:0043543 59 28 1,000 4,715E-03 0,03554967 ! fat cell differentiation GO:0045444 57 28 1,000 4,715E-03 0,03544028 ! base-excision repair GO:0006284 41 28 1,000 4,715E-03 0,03533157 ! positive regulation of MAP kinase activity GO:0043406 174 93 2,000 4,881E-03 0,03646485 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 5,052E-03 0,03762744 ! somitogenesis GO:0001756 52 29 1,000 5,052E-03 0,03751307 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 5,4E-03 0,0399753 ! regulation of B cell activation GO:0050864 55 30 1,000 5,4E-03 0,03985453 ! transcription initiation GO:0006352 171 97 2,000 5,487E-03 0,0403781 ! erythrocyte differentiation GO:0030218 62 31 1,000 5,759E-03 0,04224638 ! skeletal muscle tissue development GO:0007519 223 100 2,000 5,971E-03 0,04367068 GO:0060538|skeletal muscle organ development, ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 6,128E-03 0,0446871 ! collagen metabolic process GO:0032963 49 32 1,000 6,128E-03 0,04455411 ! spindle organization GO:0007051 50 32 1,000 6,128E-03 0,0444219 ! response to mechanical stimulus GO:0009612 60 32 1,000 6,128E-03 0,04429047 ! regulation of pH GO:0006885 56 33 1,000 6,508E-03 0,04689693 ! response to ionizing radiation GO:0010212 74 33 1,000 6,508E-03 0,046759 ! establishment of vesicle localization GO:0051650 67 33 1,000 6,508E-03 0,04662188 ! DNA damage checkpoint GO:0000077 78 35 1,000 7,299E-03 0,05213529 ! negative regulation of DNA metabolic process GO:0051053 65 35 1,000 7,299E-03 0,05198329 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 7,299E-03 0,05183218 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 1,000 7,299E-03 0,05168194 ! vesicle localization GO:0051648 70 35 1,000 7,299E-03 0,05153257 ! regulation of muscle development GO:0048634 82 36 1,000 7,709E-03 0,05427724 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 7,709E-03 0,05412127 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 7,709E-03 0,0539662 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 7,709E-03 0,05381201 ! embryonic organ development GO:0048568 67 36 1,000 7,709E-03 0,0536587 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 8,131E-03 0,05642926 ! sister chromatid segregation GO:0000819 65 37 1,000 8,131E-03 0,0562694 ! androgen receptor signaling pathway GO:0030521 81 37 1,000 8,131E-03 0,05611045 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 8,562E-03 0,05892046 ! DNA integrity checkpoint GO:0031570 82 38 1,000 8,562E-03 0,05875495 ! mitotic cell cycle checkpoint GO:0007093 76 39 1,000 9,003E-03 0,06161066 ! erythrocyte homeostasis GO:0034101 75 39 1,000 9,003E-03 0,06143856 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 9,003E-03 0,06126742 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mammary gland development GO:0030879 93 40 1,000 9,455E-03 0,06416009 ! nucleus organization GO:0006997 73 40 1,000 9,455E-03 0,06398236 ! Rho protein signal transduction GO:0007266 88 40 1,000 9,455E-03 0,06380561 ! cellular amide metabolic process GO:0043603 73 41 1,000 9,916E-03 0,06673403 ! mesenchymal cell development GO:0014031 94 41 1,000 9,916E-03 0,06655069 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 9,916E-03 0,06636836 ! gliogenesis GO:0042063 91 41 1,000 9,916E-03 0,06618703 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,01038693 0,06914245 ! ear morphogenesis GO:0042471 64 42 1,000 0,01038693 0,06895456 ! T cell differentiation GO:0030217 93 42 1,000 0,01038693 0,0687677 ! cytokinesis GO:0000910 84 42 1,000 0,01038693 0,06858184 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,01086776 0,07156314 GO:0090047|positive regulation of transcription regulator activity, ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,01086776 0,07137077 ! segmentation GO:0035282 78 43 1,000 0,01086776 0,07117943 ! response to reactive oxygen species GO:0000302 75 44 1,000 0,01135825 0,07419306 ! positive regulation of response to external stimulus GO:0032103 88 44 1,000 0,01135825 0,07399521 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 0,01185834 0,07704768 ! biopolymer methylation GO:0043414 91 45 1,000 0,01185834 0,07684331 ! B cell differentiation GO:0030183 124 45 1,000 0,01185834 0,07664002 ! mitochondrial transport GO:0006839 94 48 1,000 0,01341545 0,08647476 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,01341545 0,08624719 ! cellular component disassembly GO:0022411 89 48 1,000 0,01341545 0,08602082 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,01341545 0,08579564 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,01341545 0,08557163 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,01341545 0,08534878 ! methylation GO:0032259 97 48 1,000 0,01341545 0,0851271 ! response to calcium ion GO:0051592 94 49 1,000 0,01395317 0,08830985 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,01395317 0,08808166 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 0,01395317 0,08785465 ! protein homooligomerization GO:0051260 84 49 1,000 0,01395317 0,0876288 ! regulation of ossification GO:0030278 123 50 1,000 0,01450012 0,09083027 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,01450012 0,09059797 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,01450012 0,09036685 ! viral infectious cycle GO:0019058 104 51 1,000 0,01505623 0,09359379 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,01505623 0,09335624 ! positive regulation of binding GO:0051099 88 52 1,000 0,0156214 0,09661541 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,0156214 0,09637143 ! amino acid activation GO:0043038 98 52 1,000 0,0156214 0,09612868 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,01619558 0,09941159 ! vesicle organization GO:0016050 127 53 1,000 0,01619558 0,09916244 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 0,01619558 0,09891453 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,01619558 0,09866786 ! cartilage development GO:0051216 99 53 1,000 0,01619558 0,09842242 ! regulation of angiogenesis GO:0045765 125 54 1,000 0,0167787 0,10171304 ! regulation of muscle contraction GO:0006937 94 54 1,000 0,0167787 0,10146127 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,01737067 0,10478158 ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,01797143 0,10813842 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01815493 0,10897417 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01815493 0,10870708 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01815493 0,10844129 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01815493 0,1081768 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01815493 0,10791359 ! neuron fate determination GO:0048664 7 5 0,000 0,01815493 0,10765167 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01815493 0,10739101 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01815493 0,10713161 ! polyol transport GO:0015791 12 5 0,000 0,01815493 0,10687346 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01815493 0,10661656 ! response to superoxide GO:0000303 10 5 0,000 0,01815493 0,10636088 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01815493 0,10610643 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01815493 0,10585319 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01815493 0,10560116 ! female meiosis GO:0007143 10 5 0,000 0,01815493 0,10535033 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01815493 0,10510068 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01815493 0,10485222 ! hypothalamus development GO:0021854 9 5 0,000 0,01815493 0,10460492 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01815493 0,10435879 ! cobalt ion transport GO:0006824 11 5 0,000 0,01815493 0,10411382 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01815493 0,10386999 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01815493 0,10362731 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01815493 0,10338575 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01815493 0,10314532 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01815493 0,102906 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01815493 0,10266779 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01815493 0,10243069 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01815493 0,10219467 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01815493 0,10195974 ! transposition GO:0032196 9 5 0,000 0,01815493 0,10172589 ! negative chemotaxis GO:0050919 16 5 0,000 0,01815493 0,10149311 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01815493 0,10126139 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01815493 0,10103072 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01815493 0,10080111 ! behavioral response to pain GO:0048266 10 5 0,000 0,01815493 0,10057253 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01815493 0,10034499 ! Notch receptor processing GO:0007220 11 5 0,000 0,01815493 0,10011848 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01815493 0,09989299 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01815493 0,09966851 ! micturition GO:0060073 9 5 0,000 0,01815493 0,09944504 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01815493 0,09922257 ! copulation GO:0007620 9 5 0,000 0,01815493 0,09900109 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01815493 0,0987806 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01815493 0,09856108 ! bioluminescence GO:0008218 9 5 0,000 0,01815493 0,09834254 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01815493 0,09812497 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01815493 0,09790836 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01815493 0,0976927 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01815493 0,09747799 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01815493 0,09726423 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01815493 0,09705139 ! grooming behavior GO:0007625 6 5 0,000 0,01815493 0,09683949 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01815493 0,09662851 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01815493 0,09641845 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01815493 0,0962093 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01815493 0,09600105 ! response to protozoan GO:0001562 13 5 0,000 0,01815493 0,09579371 ! lymph vessel development GO:0001945 10 5 0,000 0,01815493 0,09558726 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01815493 0,09538169 ! endochondral ossification GO:0001958 17 5 0,000 0,01815493 0,09517701 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01815493 0,09497321 ! single strand break repair GO:0000012 8 5 0,000 0,01815493 0,09477027 ! parathyroid gland development GO:0060017 14 5 0,000 0,01815493 0,0945682 ! anagen GO:0042640 7 5 0,000 0,01815493 0,09436699 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01815493 0,09416664 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01815493 0,09396713 ! cytokine secretion GO:0050663 15 5 0,000 0,01815493 0,09376847 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01815493 0,09357065 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01815493 0,09337366 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01815493 0,09317749 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01815493 0,09298215 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01815493 0,09278763 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01815493 0,09259392 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01815493 0,09240102 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01815493 0,09220891 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01815493 0,09201761 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01815493 0,0918271 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01815493 0,09163737 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01815493 0,09144843 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01815493 0,09126026 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01815493 0,09107287 ! microvillus organization GO:0032528 8 5 0,000 0,01815493 0,09088624 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01815493 0,09070038 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01815493 0,09051528 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01815493 0,09033093 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01815493 0,09014733 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01815493 0,08996448 ! polyol catabolic process GO:0046174 9 5 0,000 0,01815493 0,08978236 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01815493 0,08960098 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01815493 0,08942034 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01815493 0,08924042 ! muscle cell migration GO:0014812 8 5 0,000 0,01815493 0,08906122 ! mitochondrial fission GO:0000266 8 5 0,000 0,01815493 0,08888274 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01815493 0,08870497 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01815493 0,08852792 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01815493 0,08835157 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01815493 0,08817592 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01815493 0,08800097 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01815493 0,08782671 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01815493 0,08765314 ! monocyte activation GO:0042117 10 5 0,000 0,01815493 0,08748025 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01815493 0,08730805 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01815493 0,08713652 ! response to food GO:0032094 6 5 0,000 0,01815493 0,08696566 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01815493 0,08679547 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01815493 0,08662595 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01815493 0,08645709 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01815493 0,08628889 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,01815493 0,08612133 ! forebrain neuron development GO:0021884 13 5 0,000 0,01815493 0,08595443 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01815493 0,08578818 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01815493 0,08562256 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01815493 0,08545759 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01815493 0,08529324 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01815493 0,08512953 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01815493 0,08496645 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01815493 0,08480399 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01815493 0,08464215 ! lipid glycosylation GO:0030259 7 5 0,000 0,01815493 0,08448093 ! nucleobase transport GO:0015851 6 5 0,000 0,01815493 0,08432032 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01815493 0,08416032 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01815493 0,08400092 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01815493 0,08384213 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01815493 0,08368394 ! basic amino acid transport GO:0015802 12 5 0,000 0,01815493 0,08352634 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01815493 0,08336934 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01815493 0,08321292 ! actin nucleation GO:0045010 11 5 0,000 0,01815493 0,08305709 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01815493 0,08290185 ! depurination GO:0045007 5 5 0,000 0,01815493 0,08274718 ! depyrimidination GO:0045008 10 5 0,000 0,01815493 0,08259309 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01815493 0,08243957 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01815493 0,08228662 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01815493 0,08213424 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01815493 0,08198242 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01815493 0,08183116 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01815493 0,08168046 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01815493 0,08153031 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01815493 0,08138071 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01815493 0,08123166 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01815493 0,08108316 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01815493 0,0809352 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01815493 0,08078777 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01815493 0,08064089 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01815493 0,08049453 ! response to arsenic GO:0046685 11 5 0,000 0,01815493 0,08034871 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01815493 0,08020341 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01815493 0,08005864 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01815493 0,07991439 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01815493 0,07977066 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01815493 0,07962745 ! response to mercury ion GO:0046689 8 5 0,000 0,01815493 0,07948474 ! response to cadmium ion GO:0046686 7 5 0,000 0,01815493 0,07934255 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01815493 0,07920087 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01815493 0,07905969 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01815493 0,07891902 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01815493 0,07877884 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01815493 0,07863916 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01815493 0,07849998 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01815493 0,07836128 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01815493 0,07822308 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01815493 0,07808536 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01815493 0,07794813 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01815493 0,07781138 ! embryonic cleavage GO:0040016 6 5 0,000 0,01815493 0,07767511 ! peroxisome fission GO:0016559 5 5 0,000 0,01815493 0,07753931 ! histone demethylation GO:0016577 13 5 0,000 0,01815493 0,07740399 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01815493 0,07726914 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01815493 0,07713476 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01815493 0,07700085 ! metaphase plate congression GO:0051310 7 5 0,000 0,01815493 0,0768674 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01815493 0,07673441 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,01815493 0,07660188 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01815493 0,07646981 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01815493 0,07633819 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01815493 0,07620702 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01815493 0,07607631 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01815493 0,07594604 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01815493 0,07581622 ! B cell homeostasis GO:0001782 13 5 0,000 0,01815493 0,07568684 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01815493 0,0755579 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01815493 0,0754294 ! metaphase GO:0051323 11 5 0,000 0,01815493 0,07530134 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01815493 0,07517371 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01815493 0,07504651 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01815493 0,07491974 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01815493 0,0747934 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01815493 0,07466749 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01815493 0,074542 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01815493 0,07441692 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01815493 0,07429227 ! response to redox state GO:0051775 6 5 0,000 0,01815493 0,07416804 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01815493 0,07404422 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01815493 0,07392081 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01815493 0,07379782 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01815493 0,07367523 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01815493 0,07355305 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01815493 0,07343127 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01815493 0,0733099 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01815493 0,07318892 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01815493 0,07306835 ! striatum development GO:0021756 14 5 0,000 0,01815493 0,07294817 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01815493 0,07282839 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01815493 0,072709 ! glial cell migration GO:0008347 10 5 0,000 0,01815493 0,07259 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01815493 0,07247138 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01815493 0,07235316 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01815493 0,07223532 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01815493 0,07211787 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01815493 0,07200079 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01815493 0,0718841 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01815493 0,07176778 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01815493 0,07165184 ! neuroprotection GO:0043526 8 5 0,000 0,01815493 0,07153627 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01815493 0,07142107 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01815493 0,07130625 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01815493 0,07119179 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01815493 0,0710777 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01815493 0,07096398 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01815493 0,07085062 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01815493 0,07073762 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01815493 0,07062498 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01815493 0,0705127 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,01815493 0,07040077 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01815493 0,0702892 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01815493 0,07017799 ! spindle assembly GO:0051225 6 5 0,000 0,01815493 0,07006712 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01815493 0,0699566 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01815493 0,06984644 ! protein palmitoylation GO:0018345 12 5 0,000 0,01815493 0,06973662 ! drug metabolic process GO:0017144 7 5 0,000 0,01815493 0,06962714 ! stem cell division GO:0017145 11 5 0,000 0,01815493 0,06951801 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01815493 0,06940921 ! organ regeneration GO:0031100 7 5 0,000 0,01815493 0,06930076 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01815493 0,06919265 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01815493 0,06908487 ! muscle fiber development GO:0048747 131 57 1,000 0,0185809 0,07059587 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,0185809 0,07048625 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,01919903 0,07271817 ! lipid modification GO:0030258 112 60 1,000 0,02046093 0,07737777 ! DNA catabolic process GO:0006308 94 60 1,000 0,02046093 0,07725818 ! regulation of heart contraction GO:0008016 123 61 1,000 0,02110457 0,07956551 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02174647 0,08185921 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02174647 0,08173327 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02174647 0,08160772 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02174647 0,08148256 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02174647 0,08135778 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02174647 0,08123338 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02174647 0,08110936 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02174647 0,08098571 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02174647 0,08086245 ! response to oxygen radical GO:0000305 11 6 0,000 0,02174647 0,08073956 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02174647 0,08061704 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02174647 0,08049489 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02174647 0,08037311 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02174647 0,0802517 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02174647 0,08013066 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02174647 0,08000998 ! forebrain regionalization GO:0021871 9 6 0,000 0,02174647 0,07988967 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02174647 0,07976971 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02174647 0,07965012 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02174647 0,07953088 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02174647 0,079412 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02174647 0,07929347 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02174647 0,0791753 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02174647 0,07905748 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02174647 0,07894001 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02174647 0,07882289 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02174647 0,07870612 ! malate metabolic process GO:0006108 13 6 0,000 0,02174647 0,07858969 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02174647 0,0784736 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02174647 0,07835786 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02174647 0,07824246 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02174647 0,07812739 ! protein refolding GO:0042026 15 6 0,000 0,02174647 0,07801267 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02174647 0,07789828 ! opsonization GO:0008228 8 6 0,000 0,02174647 0,07778423 ! mating behavior GO:0007617 7 6 0,000 0,02174647 0,07767051 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02174647 0,07755712 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02174647 0,07744406 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02174647 0,07733134 GO:0046530|photoreceptor cell differentiation, ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02174647 0,07721894 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02174647 0,07710686 ! toxin metabolic process GO:0009404 11 6 0,000 0,02174647 0,07699511 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02174647 0,07688369 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02174647 0,07677258 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02174647 0,0766618 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02174647 0,07655134 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02174647 0,07644119 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02174647 0,07633136 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02174647 0,07622185 ! thymic T cell selection GO:0045061 16 6 0,000 0,02174647 0,07611265 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02174647 0,07600376 ! protein lipoylation GO:0009249 10 6 0,000 0,02174647 0,07589518 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02174647 0,07578692 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02174647 0,07567896 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02174647 0,07557131 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02174647 0,07546396 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02174647 0,07535692 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02174647 0,07525018 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02174647 0,07514374 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02174647 0,07503761 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02174647 0,07493177 ! hyperosmotic response GO:0006972 10 6 0,000 0,02174647 0,07482624 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02174647 0,074721 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02174647 0,07461605 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02174647 0,0745114 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02174647 0,07440704 ! urea metabolic process GO:0019627 7 6 0,000 0,02174647 0,07430298 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02174647 0,0741992 ! neutrophil activation GO:0042119 7 6 0,000 0,02174647 0,07409571 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02174647 0,07399252 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02174647 0,07388961 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02174647 0,07378698 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02174647 0,07368464 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02174647 0,07358259 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02174647 0,07348081 ! neuron apoptosis GO:0051402 15 6 0,000 0,02174647 0,07337932 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02174647 0,07327811 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02174647 0,07317717 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02174647 0,07307652 ! carnitine transport GO:0015879 10 6 0,000 0,02174647 0,07297614 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02174647 0,07287603 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02174647 0,0727762 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02174647 0,07267665 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02174647 0,07257736 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02174647 0,07247835 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02174647 0,0723796 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02174647 0,07228113 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02174647 0,07218292 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02174647 0,07208498 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02174647 0,0719873 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02174647 0,07188989 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,02174647 0,07179274 ! response to UV-C GO:0010225 14 6 0,000 0,02174647 0,07169585 ! astrocyte development GO:0014002 16 6 0,000 0,02174647 0,07159923 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02174647 0,07150286 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02174647 0,07140676 ! interaction with symbiont GO:0051702 14 6 0,000 0,02174647 0,07131091 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02174647 0,07121532 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02174647 0,07111998 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02174647 0,0710249 ! response to copper ion GO:0046688 10 6 0,000 0,02174647 0,07093008 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02174647 0,0708355 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02174647 0,07074118 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02174647 0,07064711 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02174647 0,07055329 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02174647 0,07045972 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02174647 0,07036639 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02174647 0,07027332 ! hair follicle maturation GO:0048820 8 6 0,000 0,02174647 0,07018049 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02174647 0,0700879 ! Schwann cell development GO:0014044 15 6 0,000 0,02174647 0,06999556 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02174647 0,06990346 ! response to pheromone GO:0019236 6 6 0,000 0,02174647 0,0698116 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02174647 0,06971998 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02174647 0,06962861 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02174647 0,06953747 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02174647 0,06944657 ! subpallium development GO:0021544 15 6 0,000 0,02174647 0,06935591 ! neural tube patterning GO:0021532 8 6 0,000 0,02174647 0,06926549 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02174647 0,0691753 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02174647 0,06908534 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02174647 0,06899562 ! G2 phase GO:0051319 16 6 0,000 0,02174647 0,06890613 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02174647 0,06881688 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02174647 0,06872785 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02174647 0,06863905 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02174647 0,06855049 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02174647 0,06846215 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02174647 0,06837404 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02174647 0,06828615 ! receptor internalization GO:0031623 11 6 0,000 0,02174647 0,0681985 ! plasminogen activation GO:0031639 9 6 0,000 0,02174647 0,06811106 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02174647 0,06802385 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02174647 0,06793686 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02174647 0,0678501 ! protein deubiquitination GO:0016579 16 6 0,000 0,02174647 0,06776356 ! protein destabilization GO:0031648 9 6 0,000 0,02174647 0,06767723 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02174647 0,06759113 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02174647 0,06750524 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02174647 0,06741958 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02174647 0,06733413 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02174647 0,0672489 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02174647 0,06716388 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02174647 0,06707908 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02174647 0,06699449 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02174647 0,06691011 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02174647 0,06682595 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02174647 0,06674199 ! neural plate development GO:0001840 9 6 0,000 0,02174647 0,06665825 ! catecholamine transport GO:0051937 9 6 0,000 0,02174647 0,06657472 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02174647 0,0664914 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02174647 0,06640828 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02174647 0,06632538 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02174647 0,06624268 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02174647 0,06616018 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02174647 0,0660779 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02174647 0,06599581 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02174647 0,06591393 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02174647 0,06583225 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02174647 0,06575078 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02174647 0,0656695 GO:0055081|anion homeostasis, ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,02175657 0,06561889 ! regulation of mitosis GO:0007088 112 63 1,000 0,02241687 0,06752703 GO:0051783|regulation of nuclear division, ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,02241687 0,06744387 ! protein amino acid autophosphorylation GO:0046777 157 64 1,000 0,02308541 0,06936981 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,0237621 0,0713155 GO:0048609|reproductive process in a multicellular organism, ! steroid hormone receptor signaling pathway GO:0030518 146 66 1,000 0,02444689 0,07328068 ! chromosome segregation GO:0007059 127 67 1,000 0,02513971 0,07526508 ! tRNA transcription GO:0009304 17 7 0,000 0,02532498 0,07572695 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02532498 0,07563437 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02532498 0,07554203 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02532498 0,0754499 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02532498 0,075358 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02532498 0,07526632 ! sleep GO:0030431 16 7 0,000 0,02532498 0,07517487 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02532498 0,07508364 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02532498 0,07499263 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02532498 0,07490184 ! prostate gland development GO:0030850 14 7 0,000 0,02532498 0,07481127 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02532498 0,07472092 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02532498 0,07463078 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02532498 0,07454087 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02532498 0,07445117 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02532498 0,07436168 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02532498 0,07427241 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02532498 0,07418336 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02532498 0,07409451 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02532498 0,07400588 ! glycolipid transport GO:0046836 11 7 0,000 0,02532498 0,07391747 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02532498 0,07382926 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,02532498 0,07374126 ! neuron adhesion GO:0007158 14 7 0,000 0,02532498 0,07365347 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02532498 0,0735659 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02532498 0,07347853 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02532498 0,07339136 ! pericardium development GO:0060039 16 7 0,000 0,02532498 0,07330441 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02532498 0,07321766 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02532498 0,07313111 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02532498 0,07304477 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02532498 0,07295863 ! lipoprotein transport GO:0042953 14 7 0,000 0,02532498 0,0728727 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02532498 0,07278696 ! rhythmic behavior GO:0007622 17 7 0,000 0,02532498 0,07270143 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02532498 0,0726161 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02532498 0,07253097 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02532498 0,07244604 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02532498 0,07236131 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02532498 0,07227677 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02532498 0,07219244 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02532498 0,0721083 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02532498 0,07202435 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02532498 0,0719406 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02532498 0,07185705 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02532498 0,07177369 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02532498 0,07169052 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02532498 0,07160754 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02532498 0,07152476 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02532498 0,07144217 ! spinal cord patterning GO:0021511 14 7 0,000 0,02532498 0,07135977 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02532498 0,07127756 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02532498 0,07119553 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02532498 0,0711137 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02532498 0,07103205 ! adrenal gland development GO:0030325 17 7 0,000 0,02532498 0,07095059 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02532498 0,07086932 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02532498 0,07078824 ! ovulation GO:0030728 10 7 0,000 0,02532498 0,07070734 ! adenohypophysis development GO:0021984 11 7 0,000 0,02532498 0,07062662 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02532498 0,07054609 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02532498 0,07046574 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02532498 0,07038557 ! microtubule nucleation GO:0007020 21 7 0,000 0,02532498 0,07030559 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02532498 0,07022579 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02532498 0,07014617 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02532498 0,07006673 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02532498 0,06998746 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02532498 0,06990838 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02532498 0,06982948 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02532498 0,06975075 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02532498 0,06967221 ! galactose metabolic process GO:0006012 13 7 0,000 0,02532498 0,06959383 ! vesicle fusion GO:0006906 20 7 0,000 0,02532498 0,06951564 ! response to dietary excess GO:0002021 8 7 0,000 0,02532498 0,06943762 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02532498 0,06935977 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02532498 0,0692821 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02532498 0,06920461 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02532498 0,06912728 ! organ growth GO:0035265 15 7 0,000 0,02532498 0,06905013 ! nucleoside transport GO:0015858 11 7 0,000 0,02532498 0,06897315 ! nucleoside salvage GO:0043174 11 7 0,000 0,02532498 0,06889635 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02532498 0,06881971 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02532498 0,06874324 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02532498 0,06866695 ! parturition GO:0007567 16 7 0,000 0,02532498 0,06859082 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02532498 0,06851486 ! rRNA modification GO:0000154 14 7 0,000 0,02532498 0,06843907 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02532498 0,06836345 ! spindle checkpoint GO:0031577 16 7 0,000 0,02532498 0,06828799 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02532498 0,0682127 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02532498 0,06813758 ! monocyte differentiation GO:0030224 16 7 0,000 0,02532498 0,06806262 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02532498 0,06798782 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02532498 0,06791319 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02532498 0,06783873 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02532498 0,06776442 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02532498 0,06769028 ! fibrinolysis GO:0042730 11 7 0,000 0,02532498 0,0676163 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02532498 0,06754249 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02532498 0,06746883 ! eating behavior GO:0042755 8 7 0,000 0,02532498 0,06739534 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02532498 0,067322 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02532498 0,06724882 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02532498 0,06717581 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02532498 0,06710295 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,02532498 0,06703025 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02532498 0,0669577 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02532498 0,06688532 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02532498 0,06681309 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02532498 0,06674101 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02532498 0,06666909 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02532498 0,06659733 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02532498 0,06652572 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02532498 0,06645426 ! histone ubiquitination GO:0016574 9 7 0,000 0,02532498 0,06638296 ! regulation of meiosis GO:0040020 12 7 0,000 0,02532498 0,06631181 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02532498 0,06624081 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02532498 0,06616997 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02532498 0,06609927 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02532498 0,06602873 ! transcription termination GO:0006353 14 7 0,000 0,02532498 0,06595834 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02532498 0,06588809 ! anaphase GO:0051322 18 7 0,000 0,02532498 0,065818 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02532498 0,06574805 ! axonal fasciculation GO:0007413 19 7 0,000 0,02532498 0,06567826 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02532498 0,06560861 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02532498 0,06553911 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02532498 0,06546976 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02532498 0,06540055 ! diuresis GO:0030146 12 7 0,000 0,02532498 0,06533149 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02532498 0,06526257 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02532498 0,0651938 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02532498 0,06512518 ! antibiotic transport GO:0042891 9 7 0,000 0,02532498 0,0650567 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02532498 0,06498836 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02532498 0,06492017 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02532498 0,06485212 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02532498 0,06478421 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02532498 0,06471644 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02532498 0,06464882 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02532498 0,06458133 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02532498 0,06451399 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02532498 0,06444679 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02532498 0,06437973 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02532498 0,06431281 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02532498 0,06424602 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02532498 0,06417938 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02532498 0,06411287 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02532498 0,0640465 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02532498 0,06398027 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02532498 0,06391417 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02532498 0,06384821 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02532498 0,06378239 ! muscle adaptation GO:0043500 13 7 0,000 0,02532498 0,0637167 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02532498 0,06365115 ! retina homeostasis GO:0001895 12 7 0,000 0,02532498 0,06358573 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02532498 0,06352045 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02532498 0,0634553 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02532498 0,06339029 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02532498 0,0633254 ! detection of external stimulus GO:0009581 102 68 1,000 0,02584048 0,06454836 ! adaptive immune response GO:0002250 126 68 1,000 0,02584048 0,06448243 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! homeostasis of number of cells GO:0048872 131 69 1,000 0,02654915 0,06618324 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,02654915 0,06611577 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 1,000 0,0279899 0,06963272 ! B cell activation GO:0042113 179 72 1,000 0,02872185 0,07138096 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02889049 0,07172711 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02889049 0,07165429 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02889049 0,07158162 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02889049 0,07150909 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02889049 0,07143672 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02889049 0,07136448 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02889049 0,0712924 ! male meiosis GO:0007140 9 8 0,000 0,02889049 0,07122046 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02889049 0,07114866 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02889049 0,07107701 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02889049 0,07100551 ! meiotic prophase I GO:0007128 14 8 0,000 0,02889049 0,07093415 ! response to zinc ion GO:0010043 12 8 0,000 0,02889049 0,07086293 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02889049 0,07079185 ! oligopeptide transport GO:0006857 16 8 0,000 0,02889049 0,07072092 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02889049 0,07065013 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02889049 0,07057947 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02889049 0,07050897 ! signal peptide processing GO:0006465 12 8 0,000 0,02889049 0,0704386 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02889049 0,07036837 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02889049 0,07029828 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02889049 0,07022833 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02889049 0,07015852 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02889049 0,07008885 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02889049 0,07001932 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02889049 0,06994993 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02889049 0,06988067 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02889049 0,06981155 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02889049 0,06974256 ! reflex GO:0060004 17 8 0,000 0,02889049 0,06967372 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02889049 0,069605 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02889049 0,06953643 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02889049 0,06946799 ! pigment granule organization GO:0048753 17 8 0,000 0,02889049 0,06939968 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02889049 0,06933151 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02889049 0,06926347 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02889049 0,06919556 ! histidine catabolic process GO:0006548 10 8 0,000 0,02889049 0,06912779 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02889049 0,06906015 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02889049 0,06899264 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02889049 0,06892527 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02889049 0,06885802 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02889049 0,06879091 ! melanin metabolic process GO:0006582 17 8 0,000 0,02889049 0,06872393 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02889049 0,06865708 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02889049 0,06859035 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02889049 0,06852376 ! macrophage activation GO:0042116 13 8 0,000 0,02889049 0,0684573 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02889049 0,06839096 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02889049 0,06832476 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02889049 0,06825868 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02889049 0,06819273 ! purine salvage GO:0043101 12 8 0,000 0,02889049 0,06812691 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02889049 0,06806121 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02889049 0,06799564 ! osteoblast development GO:0002076 17 8 0,000 0,02889049 0,0679302 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02889049 0,06786488 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02889049 0,06779969 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02889049 0,06773462 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02889049 0,06766968 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02889049 0,06760486 ! response to UV-B GO:0010224 17 8 0,000 0,02889049 0,06754017 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02889049 0,0674756 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02889049 0,06741115 ! intermediate filament organization GO:0045109 12 8 0,000 0,02889049 0,06734683 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02889049 0,06728263 ! cellular extravasation GO:0045123 13 8 0,000 0,02889049 0,06721855 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02889049 0,06715459 ! response to antibiotic GO:0046677 11 8 0,000 0,02889049 0,06709076 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02889049 0,06702704 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02889049 0,06696345 ! DNA topological change GO:0006265 12 8 0,000 0,02889049 0,06689998 ! response to tropane GO:0014073 15 8 0,000 0,02889049 0,06683662 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,02889049 0,06677339 ! melanosome transport GO:0032402 13 8 0,000 0,02889049 0,06671028 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02889049 0,06664729 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02889049 0,06658441 ! mast cell activation GO:0045576 14 8 0,000 0,02889049 0,06652165 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02889049 0,06645902 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,02889049 0,0663965 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02889049 0,06633409 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02889049 0,06627181 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02889049 0,06620964 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02889049 0,06614759 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02889049 0,06608565 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02889049 0,06602383 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02889049 0,06596213 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02889049 0,06590054 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02889049 0,06583906 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02889049 0,0657777 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02889049 0,06571646 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02889049 0,06565533 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02889049 0,06559431 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02889049 0,0655334 ! hormone catabolic process GO:0042447 17 8 0,000 0,02889049 0,06547261 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02889049 0,06541193 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02889049 0,06535137 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02889049 0,06529091 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02889049 0,06523057 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02889049 0,06517034 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02889049 0,06511022 ! adult feeding behavior GO:0008343 10 8 0,000 0,02889049 0,06505021 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02889049 0,06499031 ! ATP catabolic process GO:0006200 11 8 0,000 0,02889049 0,06493052 ! blastocyst growth GO:0001832 19 8 0,000 0,02889049 0,06487084 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02889049 0,06481127 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02889049 0,06475181 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02889049 0,06469246 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02889049 0,06463322 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02889049 0,06457409 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02889049 0,06451506 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02889049 0,06445614 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02889049 0,06439733 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02889049 0,06433863 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02889049 0,06428003 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02889049 0,06422154 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02889049 0,06416316 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02889049 0,06410488 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02889049 0,06404671 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02889049 0,06398864 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02889049 0,06393068 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02889049 0,06387283 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,03096324 0,06839348 GO:0090046|regulation of transcription regulator activity, ! lymphocyte differentiation GO:0030098 193 76 1,000 0,03172532 0,07001352 ! axon extension GO:0048675 16 9 0,000 0,03244307 0,07153286 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03244307 0,07146836 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03244307 0,07140397 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03244307 0,0713397 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03244307 0,07127555 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03244307 0,07121151 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03244307 0,07114759 ! reproductive behavior GO:0019098 22 9 0,000 0,03244307 0,07108378 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03244307 0,07102008 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,03244307 0,0709565 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,03244307 0,07089303 ! UTP metabolic process GO:0046051 10 9 0,000 0,03244307 0,07082968 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,03244307 0,07076644 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03244307 0,07070331 ! artery development GO:0060840 25 9 0,000 0,03244307 0,07064029 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03244307 0,07057739 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03244307 0,0705146 ! equilibrioception GO:0050957 20 9 0,000 0,03244307 0,07045192 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,03244307 0,07038935 ! chemosensory behavior GO:0007635 21 9 0,000 0,03244307 0,0703269 ! microtubule bundle formation GO:0001578 22 9 0,000 0,03244307 0,07026455 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,03244307 0,07020231 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03244307 0,07014019 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03244307 0,07007817 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03244307 0,07001626 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03244307 0,06995447 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03244307 0,06989278 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03244307 0,0698312 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03244307 0,06976973 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03244307 0,06970836 ! protein targeting to ER GO:0045047 25 9 0,000 0,03244307 0,06964711 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03244307 0,06958596 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,03244307 0,06952492 ! T cell selection GO:0045058 27 9 0,000 0,03244307 0,06946399 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03244307 0,06940316 ! glycine catabolic process GO:0006546 15 9 0,000 0,03244307 0,06934244 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03244307 0,06928183 ! endosome organization GO:0007032 20 9 0,000 0,03244307 0,06922132 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03244307 0,06916092 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03244307 0,06910062 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03244307 0,06904043 ! mannose metabolic process GO:0006013 13 9 0,000 0,03244307 0,06898034 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03244307 0,06892036 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03244307 0,06886048 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03244307 0,0688007 ! receptor clustering GO:0043113 20 9 0,000 0,03244307 0,06874103 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03244307 0,06868147 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03244307 0,068622 ! retinol metabolic process GO:0042572 20 9 0,000 0,03244307 0,06856264 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03244307 0,06850338 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03244307 0,06844422 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,03244307 0,06838517 ! oligodendrocyte development GO:0014003 11 9 0,000 0,03244307 0,06832622 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03244307 0,06826737 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03244307 0,06820862 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03244307 0,06814997 ! response to amine stimulus GO:0014075 13 9 0,000 0,03244307 0,06809142 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03244307 0,06803297 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03244307 0,06797462 ! erythrocyte development GO:0048821 17 9 0,000 0,03244307 0,06791638 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03244307 0,06785823 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,03244307 0,06780018 ! renal water homeostasis GO:0003091 15 9 0,000 0,03244307 0,06774223 ! postreplication repair GO:0006301 25 9 0,000 0,03244307 0,06768438 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03244307 0,06762663 ! icosanoid secretion GO:0032309 15 9 0,000 0,03244307 0,06756898 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03244307 0,06751142 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03244307 0,06745397 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03244307 0,06739661 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03244307 0,06733935 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03244307 0,06728218 ! sterol catabolic process GO:0016127 14 9 0,000 0,03244307 0,06722512 GO:0006707|cholesterol catabolic process, ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03244307 0,06716814 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03244307 0,06711127 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,03244307 0,06705449 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,03244307 0,06699781 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03244307 0,06694123 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03244307 0,06688473 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03244307 0,06682834 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03244307 0,06677204 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03244307 0,06671583 ! purine base metabolic process GO:0006144 25 9 0,000 0,03244307 0,06665972 ! pigment granule transport GO:0051904 17 9 0,000 0,03244307 0,06660371 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03244307 0,06654778 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03244307 0,06649196 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03244307 0,06643622 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03244307 0,06638058 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03244307 0,06632503 ! mitochondrion localization GO:0051646 18 9 0,000 0,03244307 0,06626957 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,03249479 0,06631977 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,03327156 0,06784843 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,03484679 0,07100142 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,03484679 0,07094226 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 1,000 0,03564512 0,0725071 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,03598274 0,07313298 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,03598274 0,07307219 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,03598274 0,0730115 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,03598274 0,0729509 ! associative learning GO:0008306 21 10 0,000 0,03598274 0,07289041 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,03598274 0,07283003 ! phosphate transport GO:0006817 24 10 0,000 0,03598274 0,07276974 ! cell volume homeostasis GO:0006884 17 10 0,000 0,03598274 0,07270955 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,03598274 0,07264945 ! CTP metabolic process GO:0046036 11 10 0,000 0,03598274 0,07258946 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,03598274 0,07252957 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,03598274 0,07246978 ! GTP metabolic process GO:0046039 11 10 0,000 0,03598274 0,07241008 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,03598274 0,07235049 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,03598274 0,07229099 ! social behavior GO:0035176 29 10 0,000 0,03598274 0,07223159 ! smoothened signaling pathway GO:0007224 18 10 0,000 0,03598274 0,07217228 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,03598274 0,07211308 ! androgen metabolic process GO:0008209 17 10 0,000 0,03598274 0,07205397 ! phospholipid efflux GO:0033700 19 10 0,000 0,03598274 0,07199496 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,03598274 0,07193604 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,03598274 0,07187722 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,03598274 0,0718185 ! pathogenesis GO:0009405 17 10 0,000 0,03598274 0,07175987 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03598274 0,07170134 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,03598274 0,0716429 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,03598274 0,07158456 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,03598274 0,07152631 ! endoderm development GO:0007492 18 10 0,000 0,03598274 0,07146816 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,03598274 0,07141011 ! arginine catabolic process GO:0006527 17 10 0,000 0,03598274 0,07135214 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,03598274 0,07129427 ! proline metabolic process GO:0006560 13 10 0,000 0,03598274 0,0712365 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,03598274 0,07117882 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,03598274 0,07112123 ! V(D)J recombination GO:0033151 34 10 0,000 0,03598274 0,07106374 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,03598274 0,07100633 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,03598274 0,07094902 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,03598274 0,07089181 ! B cell proliferation GO:0042100 19 10 0,000 0,03598274 0,07083468 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,03598274 0,07077765 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,03598274 0,07072071 ! multicellular organism growth GO:0035264 19 10 0,000 0,03598274 0,07066386 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,03598274 0,0706071 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,03598274 0,07055043 ! ruffle organization GO:0031529 17 10 0,000 0,03598274 0,07049386 ! epithelial cell development GO:0002064 21 10 0,000 0,03598274 0,07043737 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,03598274 0,07038098 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,03598274 0,07032467 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,03598274 0,07026846 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,03598274 0,07021233 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,03598274 0,0701563 GO:0030204|chondroitin sulfate metabolic process, ! motor axon guidance GO:0008045 22 10 0,000 0,03598274 0,07010035 ! copper ion homeostasis GO:0055070 13 10 0,000 0,03598274 0,07004449 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,03598274 0,06998873 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,03598274 0,06993305 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,03598274 0,06987746 ! segment specification GO:0007379 15 10 0,000 0,03598274 0,06982195 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,03598274 0,06976654 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,03598274 0,06971121 ! blastoderm segmentation GO:0007350 19 10 0,000 0,03598274 0,06965597 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,03598274 0,06960082 ! response to dsRNA GO:0043331 23 10 0,000 0,03598274 0,06954576 ! DNA ligation GO:0006266 18 10 0,000 0,03598274 0,06949078 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,03598274 0,06943589 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,03598274 0,06938109 ! melanosome localization GO:0032400 16 10 0,000 0,03598274 0,06932637 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,03598274 0,06927174 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,03598274 0,0692172 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,03598274 0,06916274 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,03598274 0,06910837 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,03598274 0,06905408 ! induction of an organ GO:0001759 17 10 0,000 0,03598274 0,06899987 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,03598274 0,06894576 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,03598274 0,06889172 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,03598274 0,06883778 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,03598274 0,06878391 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03598274 0,06873013 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,03598274 0,06867644 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,03598274 0,06862283 ! salivary gland development GO:0007431 28 10 0,000 0,03598274 0,0685693 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,03598274 0,06851585 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,03598274 0,06846249 ! midbrain development GO:0030901 14 10 0,000 0,03598274 0,06840921 ! musculoskeletal movement GO:0050881 16 10 0,000 0,03598274 0,06835602 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,03598274 0,06830291 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,03598274 0,06824988 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,03598274 0,06819693 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,03598274 0,06814406 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,03598274 0,06809128 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,03598274 0,06803858 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,03598274 0,06798596 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,03598274 0,06793342 ! detection of calcium ion GO:0005513 24 10 0,000 0,03598274 0,06788096 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,03598274 0,06782858 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,03598274 0,06777628 ! cerebellar cortex development GO:0021695 16 10 0,000 0,03598274 0,06772407 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,03598274 0,06767193 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,03598274 0,06761988 ! response to nicotine GO:0035094 20 10 0,000 0,03598274 0,0675679 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,03598274 0,06751601 ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,03726291 0,06986437 ! response to metal ion GO:0010038 158 84 1,000 0,03808224 0,07134579 ! T cell activation GO:0042110 189 84 1,000 0,03808224 0,07129112 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,03950957 0,07390649 ! respiratory burst GO:0045730 17 11 0,000 0,03950957 0,07384994 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03950957 0,07379348 ! neuron fate specification GO:0048665 18 11 0,000 0,03950957 0,07373711 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03950957 0,07368082 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03950957 0,07362462 ! thyroid gland development GO:0030878 26 11 0,000 0,03950957 0,0735685 ! synapsis GO:0007129 14 11 0,000 0,03950957 0,07351247 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03950957 0,07345653 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,03950957 0,07340067 ! response to pain GO:0048265 27 11 0,000 0,03950957 0,07334489 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03950957 0,0732892 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,03950957 0,07323359 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 16 11 0,000 0,03950957 0,07317807 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03950957 0,07312263 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03950957 0,07306728 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03950957 0,07301201 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03950957 0,07295682 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03950957 0,07290172 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03950957 0,0728467 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03950957 0,07279176 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03950957 0,07273691 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03950957 0,07268214 ! UV protection GO:0009650 20 11 0,000 0,03950957 0,07262745 ! adult heart development GO:0007512 16 11 0,000 0,03950957 0,07257284 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03950957 0,07251831 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03950957 0,07246387 ! macroautophagy GO:0016236 19 11 0,000 0,03950957 0,07240951 ! temperature homeostasis GO:0001659 18 11 0,000 0,03950957 0,07235523 ! behavioral fear response GO:0001662 27 11 0,000 0,03950957 0,07230103 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 0,000 0,03950957 0,07224691 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03950957 0,07219288 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,03950957 0,07213892 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,03950957 0,07208505 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03950957 0,07203125 ! regulation of organ growth GO:0046620 14 11 0,000 0,03950957 0,07197754 ! pigment granule localization GO:0051875 20 11 0,000 0,03950957 0,0719239 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03950957 0,07187035 ! vasoconstriction GO:0042310 20 11 0,000 0,03950957 0,07181687 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03950957 0,07176348 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03950957 0,07171016 ! embryonic axis specification GO:0000578 19 11 0,000 0,03950957 0,07165692 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03950957 0,07160377 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03950957 0,07155069 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03950957 0,07149769 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03950957 0,07144476 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03950957 0,07139192 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03950957 0,07133916 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03950957 0,07128647 ! prophase GO:0051324 17 11 0,000 0,03950957 0,07123386 ! neuroblast proliferation GO:0007405 25 11 0,000 0,03950957 0,07118133 ! nucleosome positioning GO:0016584 15 11 0,000 0,03950957 0,07112887 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03950957 0,07107649 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03950957 0,07102419 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03950957 0,07097197 ! acid secretion GO:0046717 20 11 0,000 0,03950957 0,07091982 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03950957 0,07086775 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03950957 0,07081576 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03950957 0,07076384 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03950957 0,070712 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03950957 0,07066023 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03950957 0,07060854 ! cholesterol efflux GO:0033344 21 11 0,000 0,03950957 0,07055693 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03950957 0,07050539 ! oocyte development GO:0048599 20 11 0,000 0,03950957 0,07045392 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03950957 0,07040254 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03950957 0,07035122 ! embryonic gut development GO:0048566 19 11 0,000 0,03950957 0,07029998 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03950957 0,07024882 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03950957 0,07019773 ! activation of innate immune response GO:0002218 16 11 0,000 0,03950957 0,07014671 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03950957 0,07009577 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03950957 0,0700449 ! lysogeny GO:0030069 22 11 0,000 0,03950957 0,06999411 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03950957 0,06994339 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03950957 0,06989274 ! sequestering of metal ion GO:0051238 15 11 0,000 0,03950957 0,06984217 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,03974148 0,07020132 GO:0002696|positive regulation of leukocyte activation, ! one-carbon metabolic process GO:0006730 167 88 1,000 0,04142774 0,07312715 ! regulation of DNA binding GO:0051101 167 89 1,000 0,04228087 0,07457918 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,04302359 0,07583451 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,04302359 0,07577984 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,04302359 0,07572524 ! mating GO:0007618 17 12 0,000 0,04302359 0,07567072 ! protein complex disassembly GO:0043241 28 12 0,000 0,04302359 0,07561628 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,04302359 0,07556192 ! hippocampus development GO:0021766 29 12 0,000 0,04302359 0,07550764 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,04302359 0,07545343 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,04302359 0,07539931 ! T cell proliferation GO:0042098 32 12 0,000 0,04302359 0,07534526 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,04302359 0,07529128 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,04302359 0,07523739 ! ventral spinal cord development GO:0021517 25 12 0,000 0,04302359 0,07518357 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,04302359 0,07512983 ! drug transport GO:0015893 16 12 0,000 0,04302359 0,07507617 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,04302359 0,07502258 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,04302359 0,07496907 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,04302359 0,07491563 ! polyamine metabolic process GO:0006595 18 12 0,000 0,04302359 0,07486227 ! focal adhesion formation GO:0048041 37 12 0,000 0,04302359 0,07480899 ! mitotic spindle organization GO:0007052 23 12 0,000 0,04302359 0,07475578 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,04302359 0,07470265 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,04302359 0,0746496 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,04302359 0,07459662 ! lipid digestion GO:0044241 21 12 0,000 0,04302359 0,07454371 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,04302359 0,07449088 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04302359 0,07443813 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,04302359 0,07438544 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,04302359 0,07433284 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,04302359 0,07428031 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,04302359 0,07422785 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,04302359 0,07417546 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,04302359 0,07412315 ! snRNA metabolic process GO:0016073 30 12 0,000 0,04302359 0,07407092 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,04302359 0,07401876 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,04302359 0,07396667 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,04302359 0,07391465 ! cranial nerve development GO:0021545 23 12 0,000 0,04302359 0,07386271 ! fucose catabolic process GO:0019317 25 12 0,000 0,04302359 0,07381084 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,04302359 0,07375904 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,04302359 0,07370732 ! autonomic nervous system development GO:0048483 24 12 0,000 0,04302359 0,07365566 ! zymogen activation GO:0031638 18 12 0,000 0,04302359 0,07360409 ! T cell homeostasis GO:0043029 28 12 0,000 0,04302359 0,07355258 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,04302359 0,07350114 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,04302359 0,07344978 ! oocyte differentiation GO:0009994 21 12 0,000 0,04302359 0,07339849 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,04302359 0,07334727 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,04302359 0,07329612 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,04302359 0,07324504 GO:0042130|negative regulation of T cell proliferation, ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,04302359 0,07319403 ! defense response to fungus GO:0050832 15 12 0,000 0,04302359 0,0731431 ! developmental induction GO:0031128 22 12 0,000 0,04302359 0,07309223 GO:0045168|cell-cell signaling involved in cell fate specification, ! lamellipodium assembly GO:0030032 24 12 0,000 0,04302359 0,07304144 ! response to cold GO:0009409 17 12 0,000 0,04302359 0,07299072 ! establishment of cell polarity GO:0030010 21 12 0,000 0,04302359 0,07294006 ! regulation of synapse organization GO:0050807 18 12 0,000 0,04302359 0,07288948 ! localization within membrane GO:0051668 26 12 0,000 0,04302359 0,07283897 ! response to inorganic substance GO:0010035 173 90 1,000 0,04314057 0,07298643 ! response to unfolded protein GO:0006986 139 90 1,000 0,04314057 0,07293592 ! regulation of cell cycle process GO:0010564 161 90 1,000 0,04314057 0,07288548 ! gland development GO:0048732 220 91 1,000 0,04400679 0,07429758 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,04487948 0,07571862 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,04652486 0,07844046 ! cGMP metabolic process GO:0046068 18 13 0,000 0,04652486 0,07838636 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,04652486 0,07833234 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,04652486 0,07827839 ! peroxisomal transport GO:0043574 28 13 0,000 0,04652486 0,07822452 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,04652486 0,07817072 ! cartilage condensation GO:0001502 22 13 0,000 0,04652486 0,07811699 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,04652486 0,07806334 ! organelle fusion GO:0048284 36 13 0,000 0,04652486 0,07800976 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,04652486 0,07795626 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,04652486 0,07790283 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,04652486 0,07784947 ! endocrine pancreas development GO:0031018 25 13 0,000 0,04652486 0,07779618 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,04652486 0,07774297 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,04652486 0,07768983 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,04652486 0,07763676 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,04652486 0,07758377 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,04652486 0,07753085 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,04652486 0,077478 ! methionine metabolic process GO:0006555 31 13 0,000 0,04652486 0,07742522 ! plasma membrane organization GO:0007009 27 13 0,000 0,04652486 0,07737251 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,04652486 0,07731988 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,04652486 0,07726732 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,04652486 0,07721483 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,04652486 0,07716241 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,04652486 0,07711006 ! exocrine system development GO:0035272 34 13 0,000 0,04652486 0,07705778 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,04652486 0,07700557 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,04652486 0,07695343 ! L-glutamate transport GO:0015813 30 13 0,000 0,04652486 0,07690137 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,04652486 0,07684937 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,04652486 0,07679745 ! protein homotetramerization GO:0051289 24 13 0,000 0,04652486 0,07674559 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,04652486 0,07669381 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,04652486 0,07664209 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,04652486 0,07659045 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,04652486 0,07653887 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,04652486 0,07648736 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,04652486 0,07643593 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,04652486 0,07638456 ! histone methylation GO:0016571 29 13 0,000 0,04652486 0,07633326 ! chromatin silencing GO:0006342 29 13 0,000 0,04652486 0,07628203 ! gland morphogenesis GO:0022612 31 13 0,000 0,04652486 0,07623087 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,04652486 0,07617977 ! regulation of epidermis development GO:0045682 19 13 0,000 0,04652486 0,07612875 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,04652486 0,07607779 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,04652486 0,0760269 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,04652486 0,07597608 ! spleen development GO:0048536 24 13 0,000 0,04652486 0,07592533 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,04652486 0,07587465 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,04652486 0,07582403 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,04652486 0,07577348 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,04652486 0,075723 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,04652486 0,07567259 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,04652486 0,07562224 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,04652486 0,07557196 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,04652486 0,07552174 ! insulin secretion GO:0030073 24 13 0,000 0,04652486 0,0754716 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,04652486 0,07542151 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,04652486 0,0753715 ! acrosome reaction GO:0007340 19 13 0,000 0,04652486 0,07532155 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,04652486 0,07527167 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,04652486 0,07522185 ! female pregnancy GO:0007565 166 94 1,000 0,046644 0,07536462 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,04753573 0,07675465 ! response to protein stimulus GO:0051789 158 96 1,000 0,04843369 0,07815291 ! rRNA transcription GO:0009303 28 14 0,000 0,05001341 0,08064868 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,05001341 0,08059549 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,05001341 0,08054236 ! water transport GO:0006833 21 14 0,000 0,05001341 0,0804893 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,05001341 0,08043631 ! non-recombinational repair GO:0000726 29 14 0,000 0,05001341 0,08038339 GO:0006303|double-strand break repair via nonhomologous end joining, ! retina development in camera-type eye GO:0060041 28 14 0,000 0,05001341 0,08033054 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,05001341 0,08027776 ! RNA polyadenylation GO:0043631 32 14 0,000 0,05001341 0,08022505 ! lipid localization GO:0010876 32 14 0,000 0,05001341 0,08017241 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,05001341 0,08011984 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,05001341 0,08006734 ! regulated secretory pathway GO:0045055 24 14 0,000 0,05001341 0,0800149 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,05001341 0,07996254 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,05001341 0,07991024 ! arginine metabolic process GO:0006525 21 14 0,000 0,05001341 0,07985801 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,05001341 0,07980585 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,05001341 0,07975376 ! regulation of heart rate GO:0002027 25 14 0,000 0,05001341 0,07970173 ! fear response GO:0042596 34 14 0,000 0,05001341 0,07964978 ! organic alcohol transport GO:0015850 29 14 0,000 0,05001341 0,07959789 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,05001341 0,07954607 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,05001341 0,07949431 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,05001341 0,07944263 ! neutral amino acid transport GO:0015804 28 14 0,000 0,05001341 0,07939101 ! bone mineralization GO:0030282 18 14 0,000 0,05001341 0,07933945 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,05001341 0,07928797 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,05001341 0,07923655 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,05001341 0,0791852 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,05001341 0,07913391 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,05001341 0,07908269 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,05001341 0,07903154 ! ribosome assembly GO:0042255 18 14 0,000 0,05001341 0,07898045 ! cerebellum development GO:0021549 23 14 0,000 0,05001341 0,07892943 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,05001341 0,07887847 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,05001341 0,07882759 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,05001341 0,07877676 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,05001341 0,078726 ! NADP metabolic process GO:0006739 24 14 0,000 0,05001341 0,07867531 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,05001341 0,07862468 ! oxygen transport GO:0015671 22 14 0,000 0,05001341 0,07857412 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,05001341 0,07852362 ! male genitalia development GO:0030539 26 14 0,000 0,05001341 0,07847319 ! regulation of axon extension GO:0030516 43 14 0,000 0,05001341 0,07842282 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,05001341 0,07837252 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,05001341 0,07832228 ! mRNA transport GO:0051028 185 100 1,000 0,05208672 0,08151688 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,0534893 0,08365835 ! lactation GO:0007595 30 15 0,000 0,0534893 0,08360483 ! reproductive cellular process GO:0048610 22 15 0,000 0,0534893 0,08355137 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,0534893 0,08349799 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,0534893 0,08344467 ! superoxide anion generation GO:0042554 22 15 0,000 0,0534893 0,08339142 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,0534893 0,08333823 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,0534893 0,08328512 ! copper ion transport GO:0006825 22 15 0,000 0,0534893 0,08323207 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,0534893 0,08317909 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,0534893 0,08312618 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,0534893 0,08307333 ! sulfate transport GO:0008272 27 15 0,000 0,0534893 0,08302055 ! response to cAMP GO:0051591 25 15 0,000 0,0534893 0,08296784 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,0534893 0,0829152 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,0534893 0,08286262 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,0534893 0,08281011 ! response to hexose stimulus GO:0009746 25 15 0,000 0,0534893 0,08275766 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,0534893 0,08270528 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,0534893 0,08265297 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,0534893 0,08260073 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,0534893 0,08254855 ! regulation of exocytosis GO:0017157 26 15 0,000 0,0534893 0,08249643 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,0534893 0,08244438 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,0534893 0,0823924 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,0534893 0,08234048 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,0534893 0,08228863 ! regulation of vasodilation GO:0042312 27 15 0,000 0,0534893 0,08223685 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,0534893 0,08218512 ! water homeostasis GO:0030104 28 15 0,000 0,0534893 0,08213347 ! cofactor transport GO:0051181 30 15 0,000 0,0534893 0,08208188 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,0534893 0,08203035 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,0534893 0,08197889 ! intestinal absorption GO:0050892 31 15 0,000 0,0534893 0,08192749 ! dopamine metabolic process GO:0042417 35 15 0,000 0,0534893 0,08187616 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,0534893 0,08182489 ! heme biosynthetic process GO:0006783 33 15 0,000 0,0534893 0,08177369 ! cell killing GO:0001906 32 15 0,000 0,0534893 0,08172254 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,0534893 0,08167147 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,0534893 0,08162046 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,0534893 0,08156951 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,0534893 0,08151862 ! actin filament polymerization GO:0030041 27 15 0,000 0,0534893 0,0814678 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,0534893 0,08141704 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,05695256 0,08663456 ! positive regulation of cell size GO:0045793 29 16 0,000 0,05695256 0,08658065 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,05695256 0,08652681 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,05695256 0,08647303 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,05695256 0,08641932 ! bone remodeling GO:0046849 28 16 0,000 0,05695256 0,08636568 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,05695256 0,0863121 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,05695256 0,08625859 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05695256 0,08620515 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,05695256 0,08615177 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,05695256 0,08609846 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,05695256 0,08604521 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,05695256 0,08599203 ! startle response GO:0001964 28 16 0,000 0,05695256 0,08593892 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,05695256 0,08588587 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,05695256 0,08583289 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,05695256 0,08577997 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,05695256 0,08572712 ! protein polyubiquitination GO:0000209 41 16 0,000 0,05695256 0,08567433 ! glutamate metabolic process GO:0006536 25 16 0,000 0,05695256 0,08562161 ! pituitary gland development GO:0021983 30 16 0,000 0,05695256 0,08556895 ! response to osmotic stress GO:0006970 27 16 0,000 0,05695256 0,08551635 ! lysosomal transport GO:0007041 31 16 0,000 0,05695256 0,08546383 ! fructose metabolic process GO:0006000 25 16 0,000 0,05695256 0,08541136 ! L-amino acid transport GO:0015807 33 16 0,000 0,05695256 0,08535896 ! stem cell development GO:0048864 46 16 0,000 0,05695256 0,08530663 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,05695256 0,08525436 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,05695256 0,08520215 ! intermediate filament-based process GO:0045103 36 16 0,000 0,05695256 0,08515001 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,05695256 0,08509793 ! negative regulation of immune response GO:0050777 38 16 0,000 0,05695256 0,08504591 ! axon cargo transport GO:0008088 46 16 0,000 0,05695256 0,08499396 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,05695256 0,08494207 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,05695256 0,08489024 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,05695256 0,08483848 ! DNA replication initiation GO:0006270 28 16 0,000 0,05695256 0,08478678 ! neuron recognition GO:0008038 40 16 0,000 0,05695256 0,08473515 ! mRNA splice site selection GO:0006376 44 16 0,000 0,05695256 0,08468357 ! tissue regeneration GO:0042246 27 16 0,000 0,05695256 0,08463206 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,05695256 0,08458061 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,05695256 0,08452923 ! biomineral formation GO:0031214 22 16 0,000 0,05695256 0,0844779 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,05695256 0,08442664 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,05695256 0,08437544 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,05695256 0,08432431 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,05695256 0,08427323 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,05695256 0,08422222 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,05695256 0,08417127 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,05695256 0,08412038 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,05695256 0,08406955 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! peptide hormone processing GO:0016486 27 16 0,000 0,05695256 0,08401879 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,06040325 0,08905561 ! metencephalon development GO:0022037 32 17 0,000 0,06040325 0,0890019 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,06040325 0,08894825 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,06040325 0,08889467 ! signal complex assembly GO:0007172 47 17 0,000 0,06040325 0,08884115 ! gene silencing by RNA GO:0031047 38 17 0,000 0,06040325 0,08878769 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,06040325 0,0887343 ! glial cell development GO:0021782 28 17 0,000 0,06040325 0,08868098 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,06040325 0,08862772 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,06040325 0,08857452 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,06040325 0,08852138 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,06040325 0,08846831 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,06040325 0,08841531 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,06040325 0,08836236 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,06040325 0,08830948 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,06040325 0,08825667 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,06040325 0,08820391 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,06040325 0,08815122 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,06040325 0,0880986 ! regulation of protein binding GO:0043393 33 17 0,000 0,06040325 0,08804603 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,06040325 0,08799353 ! genitalia development GO:0048806 32 17 0,000 0,06040325 0,08794109 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,06040325 0,08788871 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,06040325 0,0878364 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,06040325 0,08778415 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,06040325 0,08773195 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,06040325 0,08767983 ! steroid catabolic process GO:0006706 34 17 0,000 0,06040325 0,08762776 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,06040325 0,08757576 ! gas transport GO:0015669 26 17 0,000 0,06040325 0,08752381 ! organic cation transport GO:0015695 32 17 0,000 0,06040325 0,08747193 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,06040325 0,08742011 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,06040325 0,08736835 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,06384142 0,09228673 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,06384142 0,09223216 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,06384142 0,09217765 ! limbic system development GO:0021761 40 18 0,000 0,06384142 0,0921232 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,06384142 0,09206882 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,06384142 0,0920145 ! adult walking behavior GO:0007628 36 18 0,000 0,06384142 0,09196025 ! patterning of blood vessels GO:0001569 43 18 0,000 0,06384142 0,09190606 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,06384142 0,09185193 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,06384142 0,09179787 ! centrosome cycle GO:0007098 26 18 0,000 0,06384142 0,09174387 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,06384142 0,09168993 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,06384142 0,09163606 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,06384142 0,09158225 ! glycine metabolic process GO:0006544 30 18 0,000 0,06384142 0,09152851 ! glutamine metabolic process GO:0006541 29 18 0,000 0,06384142 0,09147483 ! response to retinoic acid GO:0032526 31 18 0,000 0,06384142 0,09142121 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,06384142 0,09136765 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,06384142 0,09131416 ! DNA integration GO:0015074 32 18 0,000 0,06384142 0,09126072 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,06384142 0,09120736 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,06384142 0,09115405 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,06384142 0,0911008 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,06384142 0,09104762 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,06384142 0,0909945 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,06384142 0,09094144 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,06384142 0,09088845 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,06384142 0,09083551 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,06384142 0,09078264 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,06384142 0,09072983 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,06384142 0,09067708 ! detection of bacterium GO:0016045 22 18 0,000 0,06384142 0,09062439 ! nerve development GO:0021675 34 18 0,000 0,06384142 0,09057176 ! defense response to virus GO:0051607 43 18 0,000 0,06384142 0,0905192 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,06384142 0,09046669 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,06384142 0,09041425 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,06726709 0,09521061 ! positive regulation of translation GO:0045727 31 19 0,000 0,06726709 0,09515548 ! negative regulation of defense response GO:0031348 27 19 0,000 0,06726709 0,09510041 ! neuron maturation GO:0042551 46 19 0,000 0,06726709 0,09504541 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,06726709 0,09499047 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,06726709 0,09493559 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,06726709 0,09488078 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,06726709 0,09482603 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,06726709 0,09477134 ! inositol metabolic process GO:0006020 33 19 0,000 0,06726709 0,09471672 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,06726709 0,09466216 ! memory GO:0007613 34 19 0,000 0,06726709 0,09460766 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,06726709 0,09455323 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,06726709 0,09449885 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,06726709 0,09444454 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,06726709 0,0943903 ! cerebral cortex development GO:0021987 40 19 0,000 0,06726709 0,09433611 ! pigmentation during development GO:0048066 42 19 0,000 0,06726709 0,09428199 ! response to vitamin A GO:0033189 32 19 0,000 0,06726709 0,09422793 ! heme metabolic process GO:0042168 40 19 0,000 0,06726709 0,09417393 ! neuromuscular junction development GO:0007528 43 19 0,000 0,06726709 0,09411999 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,06726709 0,09406612 ! response to fungus GO:0009620 26 19 0,000 0,06726709 0,0940123 ! peptide cross-linking GO:0018149 39 19 0,000 0,06726709 0,09395855 ! protein export from nucleus GO:0006611 40 19 0,000 0,06726709 0,09390486 ! heart process GO:0003015 32 19 0,000 0,06726709 0,09385123 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,06726709 0,09379766 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,06726709 0,09374416 ! visual learning GO:0008542 38 19 0,000 0,06726709 0,09369071 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,06726709 0,09363733 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,06726709 0,093584 ! vitamin transport GO:0051180 31 19 0,000 0,06726709 0,09353074 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,06726709 0,09347754 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,06726709 0,09342439 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,06726709 0,09337131 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,06726709 0,09331829 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,06726709 0,09326533 ! cilium assembly GO:0042384 38 19 0,000 0,06726709 0,09321243 ! peptide hormone secretion GO:0030072 32 19 0,000 0,06726709 0,09315958 ! protein secretion GO:0009306 45 20 0,000 0,07068033 0,09783119 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,07068033 0,09777579 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,07068033 0,09772046 ! positive regulation of ossification GO:0045778 50 20 0,000 0,07068033 0,09766519 ! skin development GO:0043588 42 20 0,000 0,07068033 0,09760998 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,07068033 0,09755483 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,07068033 0,09749974 ! response to vitamin GO:0033273 36 20 0,000 0,07068033 0,09744472 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,07068033 0,09738976 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,07068033 0,09733486 ! bile acid metabolic process GO:0008206 34 20 0,000 0,07068033 0,09728003 ! retinoid metabolic process GO:0001523 34 20 0,000 0,07068033 0,09722525 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,07068033 0,09717054 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,07068033 0,09711589 ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,07068033 0,0970613 ! actin filament bundle formation GO:0051017 47 20 0,000 0,07068033 0,09700677 ! body fluid secretion GO:0007589 33 20 0,000 0,07068033 0,0969523 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,07068033 0,09689789 ! peptide secretion GO:0002790 38 20 0,000 0,07068033 0,09684355 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,07068033 0,09678926 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,07068033 0,09673504 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,07068033 0,09668088 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,07068033 0,09662678 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,07068033 0,09657273 ! cell-cell junction organization GO:0045216 43 20 0,000 0,07068033 0,09651875 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,07068033 0,09646483 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,07068033 0,09641097 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,07068033 0,09635717 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,07068033 0,09630343 ! regulation of glucose import GO:0046324 30 20 0,000 0,07068033 0,09624975 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,07068033 0,09619613 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,07068033 0,09614257 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,07068033 0,09608906 ! negative regulation of translation GO:0017148 32 20 0,000 0,07068033 0,09603562 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,07068033 0,09598224 ! regulation of cell killing GO:0031341 46 21 0,000 0,07408117 0,10054462 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,07408117 0,10048879 ! hormone secretion GO:0046879 39 21 0,000 0,07408117 0,10043302 ! cAMP metabolic process GO:0046058 41 21 0,000 0,07408117 0,10037732 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,07408117 0,10032168 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,07408117 0,1002661 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,07408117 0,10021058 ! ovarian follicle development GO:0001541 39 21 0,000 0,07408117 0,10015512 ! smooth muscle contraction GO:0006939 48 21 0,000 0,07408117 0,10009973 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,07408117 0,10004439 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,07408117 0,09998912 ! plasma membrane fusion GO:0045026 33 21 0,000 0,07408117 0,09993391 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,07408117 0,09987876 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,07408117 0,09982367 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,07408117 0,09976864 ! sensory perception of pain GO:0019233 33 21 0,000 0,07408117 0,09971367 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,07408117 0,09965876 ! diencephalon development GO:0021536 36 21 0,000 0,07408117 0,09960391 ! collagen fibril organization GO:0030199 62 21 0,000 0,07408117 0,09954912 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,07408117 0,0994944 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,07408117 0,09943973 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,07408117 0,09938512 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,07408117 0,09933057 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,07408117 0,09927609 ! collagen catabolic process GO:0030574 29 21 0,000 0,07408117 0,09922166 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,07408117 0,09916729 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,07408117 0,09911298 ! sperm-egg recognition GO:0035036 23 21 0,000 0,07408117 0,09905873 ! actin filament-based movement GO:0030048 47 21 0,000 0,07408117 0,09900454 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,07746967 0,10347643 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,07746967 0,10341989 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,07746967 0,10336341 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,07746967 0,10330699 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 59 22 0,000 0,07746967 0,10325063 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,07746967 0,10319433 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,07746967 0,10313809 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,07746967 0,10308192 ! vacuolar transport GO:0007034 41 22 0,000 0,07746967 0,1030258 ! central nervous system neuron development GO:0021954 47 22 0,000 0,07746967 0,10296975 ! fucose metabolic process GO:0006004 44 22 0,000 0,07746967 0,10291376 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,07746967 0,10285782 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,07746967 0,10280195 ! ureteric bud development GO:0001657 50 22 0,000 0,07746967 0,10274614 ! stem cell differentiation GO:0048863 57 22 0,000 0,07746967 0,10269039 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,07746967 0,10263471 ! cytolysis GO:0019835 27 22 0,000 0,07746967 0,10257908 ! renal system process GO:0003014 42 22 0,000 0,07746967 0,10252351 ! vasodilation GO:0042311 40 22 0,000 0,07746967 0,102468 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,07746967 0,10241255 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,07746967 0,10235716 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,07746967 0,10230184 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,07746967 0,10224657 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,07746967 0,10219136 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,07746967 0,10213621 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,07746967 0,10208112 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,07746967 0,10202609 ! sarcomere organization GO:0045214 32 22 0,000 0,07746967 0,10197112 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,07746967 0,10191621 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,07746967 0,10186135 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,07746967 0,10180656 ! gut development GO:0048565 44 22 0,000 0,07746967 0,10175183 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,07746967 0,10169715 ! protein stabilization GO:0050821 41 22 0,000 0,07746967 0,10164253 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,08084585 0,10601526 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,08084585 0,10595838 ! gluconeogenesis GO:0006094 38 23 0,000 0,08084585 0,10590157 ! glycerol metabolic process GO:0006071 40 23 0,000 0,08084585 0,10584481 ! viral genome replication GO:0019079 44 23 0,000 0,08084585 0,10578812 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,08084585 0,10573149 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,08084585 0,10567492 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,08084585 0,10561841 ! regeneration GO:0031099 42 23 0,000 0,08084585 0,10556196 ! axis specification GO:0009798 43 23 0,000 0,08084585 0,10550557 ! visual behavior GO:0007632 46 23 0,000 0,08084585 0,10544924 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,08084585 0,10539297 ! response to ethanol GO:0045471 47 23 0,000 0,08084585 0,10533676 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,08084585 0,10528061 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,08084585 0,10522452 ! peroxisome organization GO:0007031 43 23 0,000 0,08084585 0,10516849 ! lysosome organization GO:0007040 47 23 0,000 0,08084585 0,10511252 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,08084585 0,10505661 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,08084585 0,10500076 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,08084585 0,10494496 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,08084585 0,10488923 ! fatty acid transport GO:0015908 47 23 0,000 0,08084585 0,10483356 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,08084585 0,10477794 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,08084585 0,10472239 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,08084585 0,10466689 ! hormone transport GO:0009914 41 23 0,000 0,08084585 0,10461145 ! cell-cell recognition GO:0009988 28 23 0,000 0,08084585 0,10455607 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,08084585 0,10450075 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,08084585 0,10444549 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,08084585 0,10439029 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,08420978 0,10867644 GO:0016444|somatic cell DNA recombination, ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,08420978 0,10861906 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,08420978 0,10856174 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,08420978 0,10850448 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,08420978 0,10844728 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 0,000 0,08420978 0,10839015 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,08420978 0,10833307 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,08420978 0,10827605 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,08420978 0,10821909 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,08420978 0,1081622 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,08420978 0,10810536 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,08420978 0,10804858 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,08420978 0,10799186 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,08420978 0,1079352 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,08420978 0,1078786 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,08420978 0,10782206 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,08420978 0,10776558 ! membrane depolarization GO:0051899 45 24 0,000 0,08420978 0,10770916 ! pallium development GO:0021543 56 24 0,000 0,08420978 0,1076528 ! oogenesis GO:0048477 44 24 0,000 0,08420978 0,10759649 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,08420978 0,10754025 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,08420978 0,10748406 ! platelet activation GO:0030168 41 24 0,000 0,08420978 0,10742794 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,08420978 0,10737187 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,08420978 0,10731586 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,08420978 0,1072599 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,08420978 0,10720401 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,08420978 0,10714818 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,08420978 0,1070924 ! regulation of amine transport GO:0051952 41 24 0,000 0,08420978 0,10703668 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,08420978 0,10698102 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,08756149 0,11118125 ! leukocyte adhesion GO:0007159 55 25 0,000 0,08756149 0,11112349 ! phototransduction GO:0007602 37 25 0,000 0,08756149 0,1110658 ! keratinization GO:0031424 37 25 0,000 0,08756149 0,11100816 ! vacuole organization GO:0007033 49 25 0,000 0,08756149 0,11095058 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,08756149 0,11089307 ! receptor metabolic process GO:0043112 53 25 0,000 0,08756149 0,11083561 ! chromosome condensation GO:0030261 48 25 0,000 0,08756149 0,11077821 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,08756149 0,11072087 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,08756149 0,11066359 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,08756149 0,11060637 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,08756149 0,11054921 ! immunoglobulin production GO:0002377 62 25 0,000 0,08756149 0,11049211 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,08756149 0,11043507 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,08756149 0,11037808 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,08756149 0,11032116 ! liver development GO:0001889 55 25 0,000 0,08756149 0,11026429 ! myelination GO:0042552 50 26 0,000 0,09090103 0,11441072 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,09090103 0,11435181 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,09090103 0,11429295 ! molting cycle process GO:0022404 52 26 0,000 0,09090103 0,11423416 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,09090103 0,11417543 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,09090103 0,11411676 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,09090103 0,11405815 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,09090103 0,1139996 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,09090103 0,1139411 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,09090103 0,11388267 ! digestive system process GO:0022600 49 26 0,000 0,09090103 0,1138243 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,09090103 0,11376599 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,09090103 0,11370774 ! osteoblast differentiation GO:0001649 63 26 0,000 0,09090103 0,11364955 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,09090103 0,11359141 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,09090103 0,11353334 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,09090103 0,11347533 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,09090103 0,11341737 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,09090103 0,11335947 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,09090103 0,11330164 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,09090103 0,11324386 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,09090103 0,11318614 ! telomere organization GO:0032200 46 26 0,000 0,09090103 0,11312848 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,09090103 0,11307088 ! neural tube closure GO:0001843 58 26 0,000 0,09090103 0,11301334 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,09090103 0,11295586 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,09090103 0,11289843 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,09090103 0,11284106 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,09422844 0,11691217 ! embryonic pattern specification GO:0009880 49 27 0,000 0,09422844 0,11685283 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,09422844 0,11679354 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,09422844 0,11673431 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,09422844 0,11667515 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,09422844 0,11661604 ! iron ion transport GO:0006826 65 27 0,000 0,09422844 0,116557 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,09422844 0,11649801 ! superoxide metabolic process GO:0006801 41 27 0,000 0,09422844 0,11643908 ! tube lumen formation GO:0035148 59 27 0,000 0,09422844 0,11638022 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,09422844 0,11632141 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,09422844 0,11626266 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,09422844 0,11620397 ! leukocyte proliferation GO:0070661 59 27 0,000 0,09422844 0,11614534 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,09422844 0,11608677 ! neuron fate commitment GO:0048663 52 28 0,000 0,09754376 0,12011059 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,09754376 0,12005008 ! vesicle docking GO:0048278 55 28 0,000 0,09754376 0,11998963 ! circadian rhythm GO:0007623 56 28 0,000 0,09754376 0,11992924 ! dendrite development GO:0016358 67 28 0,000 0,09754376 0,11986891 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,09754376 0,11980865 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,09754376 0,11974844 ! sperm motility GO:0030317 37 28 0,000 0,09754376 0,1196883 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,09754376 0,11962821 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,09754376 0,11956819 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,09754376 0,11950823 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,09754376 0,11944832 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,09754376 0,11938848 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,09754376 0,11932869 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,09754376 0,11926897 ! glutathione metabolic process GO:0006749 42 28 0,000 0,09754376 0,11920931 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,09754376 0,1191497 ! lipid oxidation GO:0034440 48 28 0,000 0,09754376 0,11909016 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,09754376 0,11903067 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,09754376 0,11897124 ! translational initiation GO:0006413 66 29 0,000 0,10084704 0,12293878 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,10084704 0,12287746 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,10084704 0,12281621 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,10084704 0,12275502 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,10084704 0,12269388 ! primary neural tube formation GO:0014020 61 29 0,000 0,10084704 0,12263281 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,10084704 0,1225718 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,10084704 0,12251085 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,10084704 0,12244996 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,10084704 0,12238913 ! synaptogenesis GO:0007416 46 29 0,000 0,10084704 0,12232836 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,10084704 0,12226765 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,10084704 0,122207 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,10084704 0,12214641 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,10084704 0,12208588 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,10413832 0,12600788 ! phenol metabolic process GO:0018958 56 30 0,000 0,10413832 0,1259455 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,10413832 0,12588319 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,10413832 0,12582093 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,10413832 0,12575873 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,10413832 0,1256966 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,10413832 0,12563453 ! acute-phase response GO:0006953 50 30 0,000 0,10413832 0,12557252 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,10413832 0,12551057 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,10413832 0,12544868 ! myofibril assembly GO:0030239 50 30 0,000 0,10413832 0,12538685 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,10413832 0,12532508 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,10413832 0,12526338 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,10413832 0,12520173 ! cell fate determination GO:0001709 64 30 0,000 0,10413832 0,12514015 ! phospholipid transport GO:0015914 65 30 0,000 0,10413832 0,12507862 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,10413832 0,12501716 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,10413832 0,12495576 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,10413832 0,12489441 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,10413832 0,12483313 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,10413832 0,12477191 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 0,000 0,10413832 0,12471074 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,10741765 0,12857487 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,10741765 0,12851191 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,10741765 0,128449 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,10741765 0,12838616 ! cell junction assembly GO:0034329 85 31 0,000 0,10741765 0,12832338 ! regulation of innate immune response GO:0045088 57 31 0,000 0,10741765 0,12826066 ! ovulation cycle process GO:0022602 55 31 0,000 0,10741765 0,128198 ! peptide transport GO:0015833 60 31 0,000 0,10741765 0,12813541 ! male gonad development GO:0008584 56 31 0,000 0,10741765 0,12807287 ! detection of light stimulus GO:0009583 44 31 0,000 0,10741765 0,1280104 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,10741765 0,12794798 ! natural killer cell activation GO:0030101 50 31 0,000 0,10741765 0,12788563 ! ensheathment of neurons GO:0007272 64 31 0,000 0,10741765 0,12782334 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,10741765 0,12776111 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,10741765 0,12769894 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,10741765 0,12763683 ! eye morphogenesis GO:0048592 65 31 0,000 0,10741765 0,12757478 ! response to heat GO:0009408 54 31 0,000 0,10741765 0,12751279 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,10741765 0,12745086 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,11068506 0,13126389 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,11068506 0,1312002 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,11068506 0,13113657 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,11068506 0,131073 ! metanephros development GO:0001656 81 32 0,000 0,11068506 0,1310095 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,11068506 0,13094606 ! muscle cell development GO:0055001 52 32 0,000 0,11068506 0,13088268 ! mesoderm formation GO:0001707 73 32 0,000 0,11068506 0,13081936 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,11068506 0,1307561 ! ovulation cycle GO:0042698 57 32 0,000 0,11068506 0,1306929 ! peripheral nervous system development GO:0007422 68 32 0,000 0,11068506 0,13062976 ! BMP signaling pathway GO:0030509 71 32 0,000 0,11068506 0,13056669 ! hindbrain development GO:0030902 65 32 0,000 0,11068506 0,13050367 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,11068506 0,13044072 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,11068506 0,13037782 ! gene silencing GO:0016458 71 32 0,000 0,11068506 0,13031499 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,11394061 0,13408329 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,11394061 0,13401873 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,11394061 0,13395424 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,11394061 0,13388981 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,11394061 0,13382544 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,11394061 0,13376113 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,11394061 0,13369688 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,11394061 0,1336327 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,11394061 0,13356857 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,11394061 0,13350451 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,11394061 0,13344051 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,11718433 0,1371736 ! glial cell differentiation GO:0010001 67 34 0,000 0,11718433 0,13710791 ! post-embryonic development GO:0009791 76 34 0,000 0,11718433 0,13704228 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,11718433 0,1369767 ! cholesterol transport GO:0030301 62 34 0,000 0,11718433 0,1369112 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,11718433 0,13684575 ! spliceosome assembly GO:0000245 75 34 0,000 0,11718433 0,13678037 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,11718433 0,13671505 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,11718433 0,13664979 ! formation of primary germ layer GO:0001704 76 34 0,000 0,11718433 0,1365846 ! cell fate specification GO:0001708 56 34 0,000 0,11718433 0,13651946 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,11718433 0,13645439 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,11718433 0,13638938 ! adult locomotory behavior GO:0008344 62 34 0,000 0,11718433 0,13632443 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,12041626 0,14001758 ! negative regulation of secretion GO:0051048 68 35 0,000 0,12041626 0,13995097 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,12041626 0,13988442 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,12041626 0,13981793 ! membrane docking GO:0022406 69 35 0,000 0,12041626 0,13975151 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,12041626 0,13968515 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,12041626 0,13961886 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,12041626 0,13955262 ! ceramide metabolic process GO:0006672 72 35 0,000 0,12041626 0,13948645 ! telencephalon development GO:0021537 81 35 0,000 0,12041626 0,13942035 ! sterol transport GO:0015918 63 35 0,000 0,12041626 0,1393543 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,12041626 0,13928832 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,12041626 0,1392224 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,12363646 0,14287789 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,12363646 0,14281034 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,12363646 0,14274285 ! positive regulation of cell development GO:0010720 85 36 0,000 0,12363646 0,14267542 ! protein targeting to membrane GO:0006612 75 36 0,000 0,12363646 0,14260806 ! regulation of proteolysis GO:0030162 77 36 0,000 0,12363646 0,14254076 ! aerobic respiration GO:0009060 56 36 0,000 0,12363646 0,14247352 ! cytokine production GO:0001816 68 36 0,000 0,12363646 0,14240635 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,12363646 0,14233924 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,12363646 0,14227219 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,12684495 0,14589558 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,12684495 0,14582693 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,12684495 0,14575834 ! odontogenesis GO:0042476 74 37 0,000 0,12684495 0,14568981 ! actomyosin structure organization GO:0031032 68 37 0,000 0,12684495 0,14562134 ! cell junction organization GO:0034330 96 37 0,000 0,12684495 0,14555295 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,12684495 0,14548461 ! female gonad development GO:0008585 71 37 0,000 0,12684495 0,14541634 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,12684495 0,14534813 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,12684495 0,14527999 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,12684495 0,14521191 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,13004179 0,14880192 ! organic anion transport GO:0015711 82 38 0,000 0,13004179 0,14873226 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,13004179 0,14866266 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,13004179 0,14859312 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,13004179 0,14852366 GO:0006639|acylglycerol metabolic process, ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,13004179 0,14845425 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,13004179 0,14838491 ! regulation of protein stability GO:0031647 77 38 0,000 0,13004179 0,14831564 ! spermatid development GO:0007286 69 38 0,000 0,13004179 0,14824643 ! glycogen metabolic process GO:0005977 63 38 0,000 0,13004179 0,14817728 ! pigment metabolic process GO:0042440 87 38 0,000 0,13004179 0,1481082 ! neural tube formation GO:0001841 79 38 0,000 0,13004179 0,14803919 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,13322702 0,1515946 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,13322702 0,15152402 ! negative regulation of binding GO:0051100 71 39 0,000 0,13322702 0,15145351 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,13322702 0,15138307 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,13322702 0,15131269 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,13322702 0,15124238 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,13322702 0,15117213 ! glucan metabolic process GO:0044042 64 39 0,000 0,13322702 0,15110195 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,13640067 0,15462962 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,13640067 0,1545579 ! learning GO:0007612 82 40 0,000 0,13640067 0,15448625 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,13640067 0,15441466 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,13640067 0,15434314 ! mismatch repair GO:0006298 58 40 0,000 0,13640067 0,15427168 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,13640067 0,15420029 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,13640067 0,15412897 ! RNA export from nucleus GO:0006405 61 41 0,000 0,13956279 0,15762917 ! mRNA catabolic process GO:0006402 79 41 0,000 0,13956279 0,15755633 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,13956279 0,15748355 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,13956279 0,15741085 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,13956279 0,15733821 ! feeding behavior GO:0007631 69 41 0,000 0,13956279 0,15726563 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,13956279 0,15719313 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,13956279 0,15712069 ! spermatid differentiation GO:0048515 73 41 0,000 0,13956279 0,15704831 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,13956279 0,15697601 ! RNA modification GO:0009451 64 41 0,000 0,13956279 0,15690377 ! organic ether metabolic process GO:0018904 59 42 0,000 0,14271342 0,16037207 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,14271342 0,16029834 ! regulation of intracellular protein transport GO:0033157 86 42 0,000 0,14271342 0,16022467 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,14271342 0,16015107 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,14271342 0,16007754 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,14271342 0,16000408 ! regulation of protein secretion GO:0050708 77 42 0,000 0,14271342 0,15993068 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,14271342 0,15985735 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,14271342 0,15978409 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,1458526 0,16322396 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,1458526 0,16314922 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,1458526 0,16307456 ! regulation of tube size GO:0035150 76 43 0,000 0,1458526 0,16299996 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,1458526 0,16292542 ! glucose transport GO:0015758 66 43 0,000 0,1458526 0,16285096 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,1458526 0,16277657 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,1458526 0,16270224 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,1458526 0,16262798 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,1458526 0,16255379 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,1458526 0,16247966 ! ion transmembrane transport GO:0034220 79 43 0,000 0,1458526 0,16240561 ! neuron migration GO:0001764 85 43 0,000 0,1458526 0,16233162 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,14898038 0,16573728 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,14898038 0,16566184 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,14898038 0,16558647 ! hexose transport GO:0008645 68 44 0,000 0,14898038 0,16551117 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,14898038 0,16543594 ! striated muscle contraction GO:0006941 85 44 0,000 0,14898038 0,16536077 ! phagocytosis GO:0006909 105 44 0,000 0,14898038 0,16528568 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,14898038 0,16521065 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,15209679 0,16859004 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,15209679 0,16851358 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,15209679 0,16843719 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,15209679 0,16836087 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,15209679 0,16828462 ! female gamete generation GO:0007292 71 45 0,000 0,15209679 0,16820844 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,15209679 0,16813233 ! polyol metabolic process GO:0019751 77 45 0,000 0,15209679 0,16805629 ! developmental growth GO:0048589 88 45 0,000 0,15209679 0,16798031 ! maintenance of location in cell GO:0051651 101 45 0,000 0,15209679 0,16790441 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,15520187 0,17125482 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,15520187 0,1711775 ! glycolysis GO:0006096 71 46 0,000 0,15520187 0,17110026 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 0,000 0,15520187 0,17102308 ! leukocyte migration GO:0050900 75 46 0,000 0,15520187 0,17094597 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,15520187 0,17086894 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,15520187 0,17079197 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,15520187 0,17071507 ! cell growth GO:0016049 90 46 0,000 0,15520187 0,17063824 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,15520187 0,17056148 ! neural tube development GO:0021915 91 47 0,000 0,15829567 0,17388324 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,15829567 0,17380509 ! positive regulation of defense response GO:0031349 88 48 0,000 0,16137823 0,17711007 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,16137823 0,17703054 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,16137823 0,17695109 ! endosome transport GO:0016197 127 48 0,000 0,16137823 0,1768717 ! male sex differentiation GO:0046661 93 48 0,000 0,16137823 0,17679238 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,16137823 0,17671314 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,16137823 0,17663397 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,16137823 0,17655487 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,16444959 0,17983453 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,16444959 0,17975407 ! JNK cascade GO:0007254 106 49 0,000 0,16444959 0,17967368 ! regulation of action potential GO:0001508 102 50 0,000 0,16750978 0,18293536 ! regulation of ion transport GO:0043269 86 50 0,000 0,16750978 0,18285362 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,16750978 0,18277195 ! endocrine system development GO:0035270 109 50 0,000 0,16750978 0,18269035 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,16750978 0,18260883 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,16750978 0,18252738 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,16750978 0,18244601 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,16750978 0,1823647 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,17055885 0,18560146 ! peptide metabolic process GO:0006518 80 51 0,000 0,17055885 0,18551882 ! response to temperature stimulus GO:0009266 84 51 0,000 0,17055885 0,18543626 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,17055885 0,18535377 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,17359684 0,1885714 ! Notch signaling pathway GO:0007219 111 52 0,000 0,17359684 0,18848759 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,17359684 0,18840386 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,17359684 0,18832019 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,17359684 0,18823661 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,17359684 0,1881531 ! excretion GO:0007588 87 52 0,000 0,17359684 0,18806966 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,17359684 0,18798629 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,17359684 0,187903 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,17359684 0,18781979 ! respiratory electron transport chain GO:0022904 83 53 0,000 0,17662379 0,19101014 ! chromatin remodeling GO:0006338 122 53 0,000 0,17662379 0,19092562 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,17662379 0,19084118 ! synapse organization GO:0050808 102 53 0,000 0,17662379 0,19075681 ! regulation of translational initiation GO:0006446 87 54 0,000 0,17963973 0,19392835 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,17963973 0,1938427 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,17963973 0,19375711 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 0,000 0,17963973 0,19367161 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,17963973 0,19358618 ! membrane fusion GO:0006944 122 54 0,000 0,17963973 0,19350082 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,17963973 0,19341554 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,17963973 0,19333034 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,17963973 0,19324521 ! RNA catabolic process GO:0006401 103 55 0,000 0,18264471 0,1963913 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,18264471 0,1963049 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,18264471 0,19621857 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,18264471 0,19613232 ! cell recognition GO:0008037 98 55 0,000 0,18264471 0,19604615 ! cell maturation GO:0048469 107 55 0,000 0,18264471 0,19596005 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,18264471 0,19587403 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,18264471 0,19578808 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,18563877 0,19891032 ! glucose catabolic process GO:0006007 88 56 0,000 0,18563877 0,19882312 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,18563877 0,19873599 ! RNA elongation GO:0006354 90 56 0,000 0,18563877 0,19864894 ! chloride transport GO:0006821 102 57 0,000 0,18862195 0,20175281 ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,18862195 0,20166452 ! regulation of intracellular transport GO:0032386 108 57 0,000 0,18862195 0,2015763 ! regulation of actin filament length GO:0030832 118 58 0,000 0,19159428 0,20466324 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,19159428 0,20457379 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,19159428 0,20448442 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,19159428 0,20439512 ! gastrulation GO:0007369 122 58 0,000 0,19159428 0,20430591 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,19159428 0,20421677 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,19159428 0,20412771 ! maintenance of location GO:0051235 124 58 0,000 0,19159428 0,20403872 ! nuclear export GO:0051168 110 59 0,000 0,19455581 0,20710233 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,19750657 0,21015181 ! regulation of endocytosis GO:0030100 104 60 0,000 0,19750657 0,21006032 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,19750657 0,20996891 ! adult behavior GO:0030534 104 60 0,000 0,19750657 0,20987758 ! kidney development GO:0001822 133 60 0,000 0,19750657 0,20978633 ! positive regulation of secretion GO:0051047 110 61 0,000 0,2004466 0,21281662 ! regulation of cellular component size GO:0032535 125 61 0,000 0,2004466 0,21272418 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,2004466 0,21263181 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,2004466 0,21253952 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,2004466 0,21244731 ! camera-type eye development GO:0043010 126 61 0,000 0,2004466 0,21235518 ! proton transport GO:0015992 117 61 0,000 0,2004466 0,21226314 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,2004466 0,21217117 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,20337595 0,21517862 ! tRNA processing GO:0008033 102 62 0,000 0,20337595 0,21508547 ! mesoderm development GO:0007498 128 63 0,000 0,20629464 0,21807781 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,20629464 0,21798348 ! hydrogen transport GO:0006818 121 64 0,000 0,20920273 0,22096077 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,20920273 0,22086528 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,20920273 0,22076987 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,21210024 0,22373095 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,21210024 0,22363439 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,21210024 0,22353791 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,21210024 0,22344152 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,21498721 0,22638524 ! gonad development GO:0008406 115 66 0,000 0,21498721 0,2262877 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,21786369 0,22921662 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,21786369 0,22911795 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,21786369 0,22901936 ! secondary metabolic process GO:0019748 125 67 0,000 0,21786369 0,22892086 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,22072971 0,23183262 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,22072971 0,23173299 ! hexose catabolic process GO:0019320 113 68 0,000 0,22072971 0,23163345 ! extracellular matrix organization GO:0030198 146 68 0,000 0,22072971 0,23153399 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,22072971 0,23143462 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,22072971 0,23133534 ! regulation of lipase activity GO:0060191 137 68 0,000 0,22072971 0,23123614 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,22072971 0,23113702 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,2235853 0,23402695 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,2235853 0,23392672 ! urogenital system development GO:0001655 149 69 0,000 0,2235853 0,23382658 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,2235853 0,23372653 ! developmental maturation GO:0021700 128 69 0,000 0,2235853 0,23362656 ! single fertilization GO:0007338 83 69 0,000 0,2235853 0,23352668 ! cell redox homeostasis GO:0045454 114 70 0,000 0,22643051 0,23639733 ! germ cell development GO:0007281 133 70 0,000 0,22643051 0,23629635 ! activation of immune response GO:0002253 120 70 0,000 0,22643051 0,23619545 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,22643051 0,23609464 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,22926538 0,23894852 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,22926538 0,23884662 ! appendage morphogenesis GO:0035107 150 72 0,000 0,23208994 0,24168615 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,23208994 0,24158318 ! actin filament organization GO:0007015 167 72 0,000 0,23208994 0,24148029 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,23208994 0,24137749 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,23208994 0,24127477 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,23208994 0,24117215 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,23208994 0,24106961 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,23208994 0,24096716 ! appendage development GO:0048736 151 73 0,000 0,23490422 0,24378548 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,23490422 0,24368196 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,23490422 0,24357853 ! regulation of immune effector process GO:0002697 156 73 0,000 0,23490422 0,24347519 ! acute inflammatory response GO:0002526 118 74 0,000 0,23770827 0,24627706 ! amino acid transport GO:0006865 148 74 0,000 0,23770827 0,24617266 ! transition metal ion transport GO:0000041 143 75 0,000 0,24050212 0,24896046 ! reproductive structure development GO:0048608 131 75 0,000 0,24050212 0,24885501 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,24050212 0,24874966 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,24050212 0,24864439 ! eye development GO:0001654 155 75 0,000 0,24050212 0,24853921 ! axon guidance GO:0007411 162 75 0,000 0,24050212 0,24843412 ! rhythmic process GO:0048511 142 75 0,000 0,24050212 0,24832912 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,24328581 0,25109727 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,24328581 0,25099124 ! learning or memory GO:0007611 161 76 0,000 0,24328581 0,25088529 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,24328581 0,25077943 ! regulation of blood pressure GO:0008217 134 76 0,000 0,24328581 0,25067366 ! amine catabolic process GO:0009310 136 77 0,000 0,24605938 0,25342456 ! neurotransmitter transport GO:0006836 142 77 0,000 0,24605938 0,25331777 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,24605938 0,25321106 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,24605938 0,25310445 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,24605938 0,25299792 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,24605938 0,25289149 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,24882286 0,25562416 ! antigen processing and presentation GO:0019882 117 78 0,000 0,24882286 0,25551671 ! fertilization GO:0009566 99 78 0,000 0,24882286 0,25540935 ! blood coagulation GO:0007596 151 79 0,000 0,25157629 0,2581272 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,25157629 0,25801884 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,25157629 0,25791056 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,25157629 0,25780238 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,25157629 0,25769428 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,25157629 0,25758628 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,2543197 0,26028614 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,2543197 0,26017714 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,25977662 0,2656485 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,2624902 0,26831111 ! exocytosis GO:0006887 153 83 0,000 0,2624902 0,2681989 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,2624902 0,26808677 ! inorganic anion transport GO:0015698 156 83 0,000 0,2624902 0,26797474 ! response to nutrient GO:0007584 135 84 0,000 0,26519391 0,27062186 ! digestion GO:0007586 130 84 0,000 0,26519391 0,27050886 ! regulation of ligase activity GO:0051340 147 84 0,000 0,26519391 0,27039596 ! hemostasis GO:0007599 165 85 0,000 0,26788778 0,27302873 ! negative regulation of transport GO:0051051 164 85 0,000 0,26788778 0,27291487 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,26788778 0,27280111 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,26788778 0,27268744 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,26788778 0,27257387 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,26788778 0,27246039 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,27057186 0,27507576 ! regulation of lyase activity GO:0051339 169 86 0,000 0,27057186 0,27496134 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,27324617 0,27756357 ! alcohol catabolic process GO:0046164 142 87 0,000 0,27324617 0,27744821 ! nucleosome assembly GO:0006334 126 87 0,000 0,27324617 0,27733294 ! regulation of protein transport GO:0051223 165 87 0,000 0,27324617 0,27721777 GO:0070201|regulation of establishment of protein localization, ! cellular respiration GO:0045333 143 88 0,000 0,27591075 0,27980488 ! amine biosynthetic process GO:0009309 146 88 0,000 0,27591075 0,27968878 ! sensory perception of smell GO:0007608 117 88 0,000 0,27591075 0,27957277 ! chromatin assembly GO:0031497 128 88 0,000 0,27591075 0,27945686 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,27856563 0,28202894 ! tube morphogenesis GO:0035239 194 89 0,000 0,27856563 0,28191211 ! cellular defense response GO:0006968 123 89 0,000 0,27856563 0,28179538 ! regulation of neurological system process GO:0031644 175 89 0,000 0,27856563 0,28167874 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,28121086 0,28423588 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,28384646 0,28678118 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,28384646 0,28666263 ! defense response to bacterium GO:0042742 112 91 0,000 0,28384646 0,28654417 ! bone development GO:0060348 206 92 0,000 0,28647247 0,28907569 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,28647247 0,28895634 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,28908893 0,29147513 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,28908893 0,29135489 ! vitamin metabolic process GO:0006766 153 93 0,000 0,28908893 0,29123474 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,29169586 0,2937399 ! sterol metabolic process GO:0016125 166 94 0,000 0,29169586 0,29361887 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,29169586 0,29349793 ! regulation of membrane potential GO:0042391 179 94 0,000 0,29169586 0,2933771 ! regulation of defense response GO:0031347 171 95 0,000 0,29429331 0,29586772 ! nucleosome organization GO:0034728 143 95 0,000 0,29429331 0,29574601 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,29429331 0,2956244 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,29429331 0,2955029 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,29429331 0,29538149 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,29429331 0,29526019 ! sex differentiation GO:0007548 171 96 0,000 0,2968813 0,29773441 ! regulation of T cell activation GO:0050863 175 96 0,000 0,2968813 0,29761224 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,29945988 0,30007403 ! regulation of protein localization GO:0032880 188 97 0,000 0,29945988 0,299951 ! forebrain development GO:0030900 210 98 0,000 0,30202908 0,30240042 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,30202908 0,30227654 ! positive regulation of immune response GO:0050778 175 100 0,000 0,30713945 0,30726522 ! hormone metabolic process GO:0042445 171 100 0,000 0,30713945 0,30713945