pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/528-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of ossification GO:0030278 71 46 6,000 8,543E-10 1,965E-06 ! cartilage development GO:0051216 70 49 6,000 1,357E-09 1,561E-06 ! regulation of bone remodeling GO:0046850 90 53 6,000 2,403E-09 1,842E-06 ! regulation of tissue remodeling GO:0034103 91 54 6,000 2,752E-09 1,582E-06 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 1,602E-08 7,371E-06 ! collagen fibril organization GO:0030199 45 20 4,000 1,748E-08 6,7E-06 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 3,000 2,044E-08 6,716E-06 ! chondrocyte differentiation GO:0002062 17 11 3,000 9,543E-08 2,744E-05 ! cell fate commitment GO:0045165 141 92 6,000 1,198E-07 3,062E-05 ! peptidyl-amino acid modification GO:0018193 147 93 6,000 1,291E-07 2,97E-05 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 2,867E-07 5,995E-05 ! epithelial to mesenchymal transition GO:0001837 22 14 3,000 2,867E-07 5,495E-05 ! neutrophil chemotaxis GO:0030593 21 16 3,000 5,179E-07 9,164E-05 ! mesenchymal cell development GO:0014031 64 38 4,000 5,333E-07 8,762E-05 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 7,237E-07 1,11E-04 ! nuclear migration GO:0007097 10 5 2,000 7,237E-07 1,04E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 7,237E-07 9,791E-05 GO:0031272|regulation of pseudopodium assembly, ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 8,653E-07 1,106E-04 ! regulation of gene-specific transcription GO:0032583 69 43 4,000 1,006E-06 1,218E-04 ! positive regulation of ossification GO:0045778 30 19 3,000 1,092E-06 1,256E-04 ! ossification GO:0001503 134 82 5,000 1,271E-06 1,392E-04 GO:0060348|bone development, ! positive regulation of osteoblast differentiation GO:0045669 33 20 3,000 1,361E-06 1,423E-04 ! ER overload response GO:0006983 7 6 2,000 1,443E-06 1,443E-04 ! macrophage differentiation GO:0030225 10 6 2,000 1,443E-06 1,383E-04 ! positive regulation of bone remodeling GO:0046852 33 21 3,000 1,676E-06 1,542E-04 GO:0034105|positive regulation of tissue remodeling, ! cell cycle arrest GO:0007050 150 86 5,000 1,683E-06 1,489E-04 ! positive regulation of growth GO:0045927 67 50 4,000 2,164E-06 1,844E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 2,464E-06 2,024E-04 ! osteoblast differentiation GO:0001649 40 23 3,000 2,464E-06 1,954E-04 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 2,464E-06 1,889E-04 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 2,517E-06 1,868E-04 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 2,000 2,517E-06 1,809E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 2,517E-06 1,755E-04 ! B cell lineage commitment GO:0002326 17 7 2,000 2,517E-06 1,703E-04 ! establishment of nucleus localization GO:0040023 13 7 2,000 2,517E-06 1,654E-04 ! T cell lineage commitment GO:0002360 12 7 2,000 2,517E-06 1,608E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 2,947E-06 1,832E-04 ! regulation of osteoblast differentiation GO:0045667 37 24 3,000 2,947E-06 1,784E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 3,498E-06 2,063E-04 GO:0045936|negative regulation of phosphate metabolic process, ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 3,498E-06 2,011E-04 ! induction of positive chemotaxis GO:0050930 14 8 2,000 4,016E-06 2,253E-04 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 2,000 4,016E-06 2,199E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 4,016E-06 2,148E-04 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 4,179E-06 2,185E-04 ! extracellular matrix organization GO:0030198 103 61 4,000 5,861E-06 2,995E-04 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 6,005E-06 3,003E-04 ! nucleus localization GO:0051647 15 9 2,000 6,005E-06 2,939E-04 ! negative regulation of cell growth GO:0030308 106 62 4,000 6,354E-06 3,045E-04 ! negative regulation of cell size GO:0045792 108 64 4,000 7,437E-06 3,491E-04 ! response to mechanical stimulus GO:0009612 43 31 3,000 8,534E-06 3,926E-04 ! leukocyte chemotaxis GO:0030595 43 31 3,000 8,534E-06 3,849E-04 GO:0060326|cell chemotaxis, ! hair follicle morphogenesis GO:0031069 17 10 2,000 8,553E-06 3,783E-04 ! regulation of cell projection assembly GO:0060491 20 10 2,000 8,553E-06 3,712E-04 ! positive regulation of cell development GO:0010720 54 33 3,000 1,103E-05 4,697E-04 ! filopodium assembly GO:0046847 19 11 2,000 1,172E-05 4,903E-04 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 1,172E-05 4,815E-04 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 2,000 1,172E-05 4,731E-04 ! negative regulation of glucose import GO:0046325 14 11 2,000 1,172E-05 4,649E-04 GO:0010829|negative regulation of glucose transport, ! cellular response to insulin stimulus GO:0032869 52 34 3,000 1,246E-05 4,857E-04 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 1,521E-05 5,829E-04 ! gland morphogenesis GO:0022612 23 12 2,000 1,558E-05 5,876E-04 ! response to gamma radiation GO:0010332 20 12 2,000 1,558E-05 5,781E-04 ! microspike assembly GO:0030035 23 12 2,000 1,558E-05 5,69E-04 ! negative regulation of growth GO:0045926 123 75 4,000 1,624E-05 5,836E-04 ! pigmentation GO:0043473 74 38 3,000 1,958E-05 6,927E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 2,02E-05 7,039E-04 ! epidermis morphogenesis GO:0048730 29 14 2,000 2,563E-05 8,798E-04 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 2,563E-05 8,669E-04 GO:0060675|ureteric bud morphogenesis, ! regulation of DNA metabolic process GO:0051052 135 85 4,000 2,986E-05 9,955E-04 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 3,194E-05 1,049E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 3,194E-05 1,035E-03 ! positive regulation of neuron apoptosis GO:0043525 29 15 2,000 3,194E-05 1,02E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 3,000 3,221E-05 1,015E-03 ! leukocyte migration GO:0050900 60 43 3,000 3,221E-05 1,001E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 3,221E-05 9,878E-04 ! leukocyte differentiation GO:0002521 143 90 4,000 3,936E-05 1,191E-03 ! response to UV GO:0009411 75 46 3,000 4,219E-05 1,26E-03 ! regulation of neuron apoptosis GO:0043523 77 47 3,000 4,596E-05 1,355E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 4,744E-05 1,381E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 4,744E-05 1,364E-03 ! heart morphogenesis GO:0003007 65 48 3,000 4,998E-05 1,419E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 4,998E-05 1,402E-03 ! regulation of glucose import GO:0046324 21 18 2,000 5,676E-05 1,573E-03 GO:0010827|regulation of glucose transport, ! extracellular structure organization GO:0043062 156 99 4,000 6,219E-05 1,703E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 6,358E-05 1,72E-03 ! response to alkaloid GO:0043279 32 19 2,000 6,719E-05 1,797E-03 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 2,000 6,719E-05 1,776E-03 ! skeletal system morphogenesis GO:0048705 78 53 3,000 7,403E-05 1,935E-03 ! positive regulation of locomotion GO:0040017 35 20 2,000 7,881E-05 2,037E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 2,000 7,881E-05 2,014E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 9,167E-05 2,317E-03 ! regulation of chemotaxis GO:0050920 36 21 2,000 9,167E-05 2,292E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 9,167E-05 2,267E-03 ! cell aging GO:0007569 32 21 2,000 9,167E-05 2,243E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 9,167E-05 2,219E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 9,167E-05 2,196E-03 ! regulation of bone mineralization GO:0030500 29 21 2,000 9,167E-05 2,174E-03 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 9,197E-05 2,158E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 9,197E-05 2,137E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 9,859E-05 2,268E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 1,056E-04 2,404E-03 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 1,058E-04 2,386E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 1,058E-04 2,363E-03 ! molting cycle process GO:0022404 40 22 2,000 1,058E-04 2,34E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! ureteric bud development GO:0001657 32 22 2,000 1,058E-04 2,318E-03 ! regulation of behavior GO:0050795 38 22 2,000 1,058E-04 2,296E-03 ! protein tetramerization GO:0051262 39 22 2,000 1,058E-04 2,275E-03 ! regulation of heart contraction GO:0008016 91 60 3,000 1,205E-04 2,567E-03 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 1,213E-04 2,56E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 1,213E-04 2,537E-03 ! negative regulation of DNA replication GO:0008156 35 23 2,000 1,213E-04 2,514E-03 ! regulation of biomineral formation GO:0070167 31 23 2,000 1,213E-04 2,491E-03 ! negative regulation of transferase activity GO:0051348 105 61 3,000 1,286E-04 2,617E-03 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 1,382E-04 2,789E-03 ! mitochondrial membrane organization GO:0007006 39 24 2,000 1,382E-04 2,765E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 1,459E-04 2,892E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 1,551E-04 3,049E-03 ! iron ion homeostasis GO:0055072 39 25 2,000 1,566E-04 3,053E-03 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 1,753E-04 3,388E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,753E-04 3,36E-03 ! epithelial cell proliferation GO:0050673 6 5 1,000 1,753E-04 3,332E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 1,753E-04 3,305E-03 ! valine metabolic process GO:0006573 8 5 1,000 1,753E-04 3,278E-03 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 1,000 1,753E-04 3,252E-03 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 1,753E-04 3,226E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 1,753E-04 3,2E-03 ! muscle cell proliferation GO:0033002 8 5 1,000 1,753E-04 3,175E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 1,753E-04 3,15E-03 ! regulation of hair follicle development GO:0051797 9 5 1,000 1,753E-04 3,126E-03 GO:0042634|regulation of hair cycle, ! glial cell migration GO:0008347 10 5 1,000 1,753E-04 3,102E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 1,753E-04 3,078E-03 ! regulation of sensory perception GO:0051931 6 5 1,000 1,753E-04 3,055E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 1,753E-04 3,032E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,765E-04 3,029E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 1,98E-04 3,373E-03 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 3,000 2,195E-04 3,713E-03 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 2,195E-04 3,686E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 2,21E-04 3,684E-03 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 2,21E-04 3,657E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 2,21E-04 3,631E-03 ! BMP signaling pathway GO:0030509 40 28 2,000 2,21E-04 3,606E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 2,448E-04 3,965E-03 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 3,000 2,448E-04 3,937E-03 ! mitochondrion organization GO:0007005 104 73 3,000 2,581E-04 4,123E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 2,622E-04 4,16E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 2,622E-04 4,131E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 2,622E-04 4,103E-03 ! regulation of odontogenesis GO:0042481 8 6 1,000 2,622E-04 4,075E-03 ! pigment granule organization GO:0048753 11 6 1,000 2,622E-04 4,048E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 2,622E-04 4,021E-03 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 1,000 2,622E-04 3,995E-03 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! microtubule nucleation GO:0007020 10 6 1,000 2,622E-04 3,968E-03 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 2,622E-04 3,942E-03 ! male sex determination GO:0030238 9 6 1,000 2,622E-04 3,917E-03 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 1,000 2,622E-04 3,891E-03 ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 2,622E-04 3,866E-03 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 2,622E-04 3,842E-03 ! salivary gland morphogenesis GO:0007435 11 6 1,000 2,622E-04 3,818E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 2,622E-04 3,794E-03 ! midbrain development GO:0030901 6 6 1,000 2,622E-04 3,77E-03 ! response to oxygen levels GO:0070482 137 74 3,000 2,72E-04 3,886E-03 ! hindbrain development GO:0030902 45 30 2,000 2,723E-04 3,866E-03 ! metanephros development GO:0001656 58 31 2,000 3,005E-04 4,241E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 3,306E-04 4,637E-03 ! positive regulation of protein modification process GO:0031401 107 78 3,000 3,33E-04 4,641E-03 ! carbohydrate homeostasis GO:0033500 39 33 2,000 3,626E-04 5,024E-03 GO:0042593|glucose homeostasis, ! negative regulation of hydrolase activity GO:0051346 50 33 2,000 3,626E-04 4,994E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 3,661E-04 5,013E-03 ! fibril organization GO:0043206 13 7 1,000 3,661E-04 4,983E-03 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 3,661E-04 4,954E-03 ! regulation of pigmentation during development GO:0048070 15 7 1,000 3,661E-04 4,925E-03 ! organ growth GO:0035265 11 7 1,000 3,661E-04 4,896E-03 ! behavioral fear response GO:0001662 13 7 1,000 3,661E-04 4,868E-03 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 3,661E-04 4,84E-03 ! response to UV-B GO:0010224 11 7 1,000 3,661E-04 4,812E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 3,661E-04 4,785E-03 ! response to tumor cell GO:0002347 12 7 1,000 3,661E-04 4,758E-03 ! peptidyl-threonine modification GO:0018210 18 7 1,000 3,661E-04 4,731E-03 ! positive regulation of epidermis development GO:0045684 11 7 1,000 3,661E-04 4,705E-03 ! dopamine biosynthetic process GO:0042416 15 7 1,000 3,661E-04 4,678E-03 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 3,661E-04 4,653E-03 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 3,965E-04 5,01E-03 ! DNA integrity checkpoint GO:0031570 57 34 2,000 3,965E-04 4,983E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 4,622E-04 5,777E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 4,832E-04 6,007E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 4,869E-04 6,02E-03 ! succinate metabolic process GO:0006105 14 8 1,000 4,869E-04 5,988E-03 ! regulation of telomere maintenance GO:0032204 10 8 1,000 4,869E-04 5,956E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 4,869E-04 5,925E-03 ! negative regulation of DNA replication initiation GO:0032297 9 8 1,000 4,869E-04 5,893E-03 GO:0000076|DNA replication checkpoint, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 4,869E-04 5,863E-03 ! middle ear morphogenesis GO:0042474 9 8 1,000 4,869E-04 5,832E-03 ! melanin metabolic process GO:0006582 12 8 1,000 4,869E-04 5,802E-03 ! regulation of smoothened signaling pathway GO:0008589 13 8 1,000 4,869E-04 5,772E-03 ! regulation of gliogenesis GO:0014013 20 8 1,000 4,869E-04 5,742E-03 GO:0045685|regulation of glial cell differentiation, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 4,869E-04 5,713E-03 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 4,869E-04 5,684E-03 ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 5,049E-04 5,865E-03 ! interphase GO:0051325 159 88 3,000 5,272E-04 6,094E-03 ! regulation of neurogenesis GO:0050767 153 89 3,000 5,503E-04 6,328E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 5,964E-04 6,824E-03 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 5,964E-04 6,79E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 6,242E-04 7,073E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 6,242E-04 7,038E-03 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 6,242E-04 7,004E-03 ! regulation of glycolysis GO:0006110 15 9 1,000 6,242E-04 6,97E-03 ! T cell selection GO:0045058 18 9 1,000 6,242E-04 6,936E-03 ! phosphagen metabolic process GO:0006599 12 9 1,000 6,242E-04 6,903E-03 GO:0006600|creatine metabolic process, ! positive regulation of peptide secretion GO:0002793 15 9 1,000 6,242E-04 6,87E-03 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 6,242E-04 6,837E-03 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 6,242E-04 6,804E-03 ! regulation of DNA replication initiation GO:0030174 13 9 1,000 6,242E-04 6,772E-03 ! oocyte differentiation GO:0009994 12 9 1,000 6,242E-04 6,741E-03 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 6,242E-04 6,709E-03 ! spleen development GO:0048536 15 9 1,000 6,242E-04 6,678E-03 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 6,242E-04 6,647E-03 ! response to nicotine GO:0035094 16 9 1,000 6,242E-04 6,616E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 6,428E-04 6,782E-03 ! detection of stimulus involved in sensory perception GO:0050906 50 40 2,000 6,428E-04 6,751E-03 ! T cell differentiation GO:0030217 65 40 2,000 6,428E-04 6,72E-03 ! B cell differentiation GO:0030183 62 40 2,000 6,428E-04 6,689E-03 ! response to light stimulus GO:0009416 153 96 3,000 7,322E-04 7,586E-03 ! mitochondrial transport GO:0006839 60 42 2,000 7,423E-04 7,657E-03 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 7,423E-04 7,622E-03 ! regulation of B cell proliferation GO:0030888 15 10 1,000 7,782E-04 7,954E-03 ! regulation of phosphatase activity GO:0010921 21 10 1,000 7,782E-04 7,919E-03 ! positive regulation of heart contraction GO:0045823 14 10 1,000 7,782E-04 7,884E-03 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 7,782E-04 7,85E-03 ! response to X-ray GO:0010165 16 10 1,000 7,782E-04 7,816E-03 ! B cell proliferation GO:0042100 14 10 1,000 7,782E-04 7,782E-03 ! fear response GO:0042596 16 10 1,000 7,782E-04 7,748E-03 ! negative regulation of ossification GO:0030279 19 10 1,000 7,782E-04 7,714E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 7,782E-04 7,681E-03 ! alpha-beta T cell activation GO:0046631 16 10 1,000 7,782E-04 7,649E-03 ! salivary gland development GO:0007431 22 10 1,000 7,782E-04 7,616E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 7,782E-04 7,584E-03 GO:0043470|regulation of carbohydrate catabolic process, ! cardiac cell differentiation GO:0035051 16 10 1,000 7,782E-04 7,552E-03 ! activation of caspase activity GO:0006919 65 43 2,000 7,956E-04 7,689E-03 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 7,956E-04 7,657E-03 ! regulation of cell projection organization GO:0031344 83 44 2,000 8,512E-04 8,158E-03 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 8,512E-04 8,124E-03 ! regulation of inflammatory response GO:0050727 60 44 2,000 8,512E-04 8,09E-03 ! detection of abiotic stimulus GO:0009582 58 44 2,000 8,512E-04 8,057E-03 ! positive regulation of defense response GO:0031349 59 45 2,000 9,093E-04 8,571E-03 ! virus-host interaction GO:0019048 17 11 1,000 9,485E-04 8,904E-03 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 9,485E-04 8,868E-03 ! plasma membrane organization GO:0007009 18 11 1,000 9,485E-04 8,832E-03 ! focal adhesion formation GO:0048041 24 11 1,000 9,485E-04 8,796E-03 ! regulation of intracellular pH GO:0051453 17 11 1,000 9,485E-04 8,761E-03 ! T cell homeostasis GO:0043029 20 11 1,000 9,485E-04 8,726E-03 ! digestive tract morphogenesis GO:0048546 15 11 1,000 9,485E-04 8,691E-03 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! positive regulation of caspase activity GO:0043280 72 48 2,000 1,098E-03 0,01002404 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 1,098E-03 9,984E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,135E-03 0,01027802 ! cartilage condensation GO:0001502 18 12 1,000 1,135E-03 0,01023771 ! positive regulation of cell growth GO:0030307 16 12 1,000 1,135E-03 0,01019772 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 1,135E-03 0,01015804 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,135E-03 0,01011867 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,135E-03 0,0100796 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,135E-03 0,01004083 ! regulation of epidermis development GO:0045682 17 12 1,000 1,135E-03 0,01000236 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 1,166E-03 0,01023917 ! ear development GO:0043583 72 50 2,000 1,237E-03 0,0108185 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 1,237E-03 0,01077752 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,338E-03 0,01161067 ! exocrine system development GO:0035272 27 13 1,000 1,338E-03 0,01156702 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 1,338E-03 0,0115237 ! regulation of cellular pH GO:0030641 20 13 1,000 1,338E-03 0,0114807 ! cellular pigmentation GO:0033059 24 13 1,000 1,338E-03 0,01143802 ! positive regulation of bone mineralization GO:0030501 19 13 1,000 1,338E-03 0,01139566 ! lymphocyte homeostasis GO:0002260 24 13 1,000 1,338E-03 0,01135361 ! aging GO:0007568 79 52 2,000 1,386E-03 0,01172358 ! establishment of organelle localization GO:0051656 85 52 2,000 1,386E-03 0,01168064 ! kidney development GO:0001822 90 53 2,000 1,465E-03 0,01229901 ! cell projection assembly GO:0030031 76 53 2,000 1,465E-03 0,01225428 ! regulation of protein complex assembly GO:0043254 81 54 2,000 1,547E-03 0,01288905 ! detection of external stimulus GO:0009581 66 54 2,000 1,547E-03 0,01284252 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 1,556E-03 0,01287701 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,556E-03 0,01283085 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 1,556E-03 0,01278503 ! startle response GO:0001964 21 14 1,000 1,556E-03 0,01273953 ! cellular response to starvation GO:0009267 21 14 1,000 1,556E-03 0,01269435 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,556E-03 0,0126495 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,556E-03 0,01260496 ! positive regulation of biomineral formation GO:0070169 20 14 1,000 1,556E-03 0,01256073 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 1,556E-03 0,01251681 ! catecholamine biosynthetic process GO:0042423 23 14 1,000 1,556E-03 0,0124732 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 1,718E-03 0,01372085 ! positive regulation of cell size GO:0045793 20 15 1,000 1,791E-03 0,01425345 ! metencephalon development GO:0022037 19 15 1,000 1,791E-03 0,0142043 ! skin development GO:0043588 25 15 1,000 1,791E-03 0,01415549 ! lipid phosphorylation GO:0046834 23 15 1,000 1,791E-03 0,01410701 ! myoblast differentiation GO:0045445 27 15 1,000 1,791E-03 0,01405886 ! regulation of survival gene product expression GO:0045884 20 15 1,000 1,791E-03 0,01401104 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 1,791E-03 0,01396355 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 1,791E-03 0,01391637 ! dopamine metabolic process GO:0042417 30 15 1,000 1,791E-03 0,01386952 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 1,791E-03 0,01382297 ! defense response to virus GO:0051607 27 15 1,000 1,791E-03 0,01377674 ! activation of MAPK activity GO:0000187 84 59 2,000 1,997E-03 0,01530813 ! lung development GO:0030324 94 59 2,000 1,997E-03 0,01525728 ! myeloid cell differentiation GO:0030099 85 59 2,000 1,997E-03 0,01520676 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 2,041E-03 0,0154945 ! protein amino acid acetylation GO:0006473 28 16 1,000 2,041E-03 0,01544353 ! regulation of protein binding GO:0043393 27 16 1,000 2,041E-03 0,0153929 ! regulation of dephosphorylation GO:0035303 33 16 1,000 2,041E-03 0,01534259 ! negative regulation of immune response GO:0050777 28 16 1,000 2,041E-03 0,01529262 ! DNA replication initiation GO:0006270 25 16 1,000 2,041E-03 0,01524297 ! oogenesis GO:0048477 23 16 1,000 2,041E-03 0,01519364 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 2,041E-03 0,01514463 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 2,041E-03 0,01509593 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 2,041E-03 0,01504754 ! regulation of homeostatic process GO:0032844 105 60 2,000 2,095E-03 0,01539794 ! urogenital system development GO:0001655 101 61 2,000 2,197E-03 0,01609409 ! respiratory tube development GO:0030323 99 62 2,000 2,302E-03 0,01680787 ! organelle localization GO:0051640 96 62 2,000 2,302E-03 0,01675468 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 2,307E-03 0,016739 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 2,307E-03 0,01668636 ! regulation of viral genome replication GO:0045069 24 17 1,000 2,307E-03 0,01663405 ! cell-substrate junction assembly GO:0007044 39 17 1,000 2,307E-03 0,01658207 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 2,307E-03 0,01653041 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 2,307E-03 0,01647908 ! cell cycle checkpoint GO:0000075 108 64 2,000 2,521E-03 0,01794881 ! respiratory system development GO:0060541 100 64 2,000 2,521E-03 0,01789341 ! positive regulation of DNA replication GO:0045740 29 18 1,000 2,588E-03 0,01831762 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 1,000 2,588E-03 0,01826143 ! pancreas development GO:0031016 26 18 1,000 2,588E-03 0,01820559 ! pigmentation during development GO:0048066 31 18 1,000 2,588E-03 0,01815008 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 2,588E-03 0,01809492 ! somitogenesis GO:0001756 24 18 1,000 2,588E-03 0,01804008 ! cellular response to nutrient levels GO:0031669 27 18 1,000 2,588E-03 0,01798558 ! gut development GO:0048565 26 18 1,000 2,588E-03 0,01793141 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 2,588E-03 0,01787756 ! regulation of caspase activity GO:0043281 97 65 2,000 2,635E-03 0,01814268 ! B cell activation GO:0042113 104 65 2,000 2,635E-03 0,01808852 ! protein oligomerization GO:0051259 100 65 2,000 2,635E-03 0,01803469 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 2,872E-03 0,01960167 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 2,885E-03 0,01963144 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 2,885E-03 0,01957353 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regeneration GO:0031099 32 19 1,000 2,885E-03 0,01951596 ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 2,885E-03 0,01945873 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 2,885E-03 0,01940183 ! apoptotic nuclear changes GO:0030262 24 19 1,000 2,885E-03 0,01934526 ! response to starvation GO:0042594 30 19 1,000 2,885E-03 0,01928903 ! sex determination GO:0007530 29 19 1,000 2,885E-03 0,01923312 ! renal system process GO:0003014 35 19 1,000 2,885E-03 0,01917753 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 2,885E-03 0,01912226 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 2,885E-03 0,01906731 ! activation of protein kinase activity GO:0032147 102 69 2,000 3,122E-03 0,02057672 ! response to drug GO:0042493 108 69 2,000 3,122E-03 0,02051793 ! response to ethanol GO:0045471 37 20 1,000 3,197E-03 0,02094745 ! multicellular organismal response to stress GO:0033555 32 20 1,000 3,197E-03 0,02088794 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 3,197E-03 0,02082876 ! positive regulation of B cell activation GO:0050871 31 20 1,000 3,197E-03 0,02076993 ! response to metal ion GO:0010038 103 70 2,000 3,252E-03 0,02107103 ! humoral immune response GO:0006959 86 70 2,000 3,252E-03 0,02101184 ! eye development GO:0001654 111 70 2,000 3,252E-03 0,02095298 ! lymphocyte differentiation GO:0030098 113 71 2,000 3,386E-03 0,02175054 ! regulation of peptidase activity GO:0052547 106 72 2,000 3,522E-03 0,02256481 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 3,524E-03 0,02251198 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 3,524E-03 0,02244962 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 3,524E-03 0,02238761 ! protein amino acid acylation GO:0043543 37 21 1,000 3,524E-03 0,02232593 ! ovarian follicle development GO:0001541 30 21 1,000 3,524E-03 0,0222646 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 3,524E-03 0,0222036 ! regulation of insulin secretion GO:0050796 26 21 1,000 3,524E-03 0,02214293 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 3,524E-03 0,0220826 ! response to cytokine stimulus GO:0034097 47 21 1,000 3,524E-03 0,02202259 ! negative regulation of transport GO:0051051 116 73 2,000 3,662E-03 0,0228252 ! tube morphogenesis GO:0035239 118 73 2,000 3,662E-03 0,02276351 ! protein import into nucleus GO:0006606 118 74 2,000 3,805E-03 0,02359014 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 3,865E-03 0,02389894 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 3,865E-03 0,02383487 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 3,865E-03 0,02377114 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 3,865E-03 0,02370775 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 3,865E-03 0,0236447 ! leukocyte homeostasis GO:0001776 33 22 1,000 3,865E-03 0,02358198 ! response to inorganic substance GO:0010035 115 75 2,000 3,952E-03 0,02404539 ! response to nutrient GO:0007584 104 75 2,000 3,952E-03 0,02398194 ! nuclear import GO:0051170 121 75 2,000 3,952E-03 0,02391883 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 4,222E-03 0,02548697 ! embryonic pattern specification GO:0009880 31 23 1,000 4,222E-03 0,02542025 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 4,222E-03 0,02535388 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 4,222E-03 0,02528785 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 4,222E-03 0,02522217 ! regulation of viral reproduction GO:0050792 32 23 1,000 4,222E-03 0,02515683 ! interaction with host GO:0051701 37 23 1,000 4,222E-03 0,02509182 ! lymphocyte proliferation GO:0046651 36 23 1,000 4,222E-03 0,02502715 ! gland development GO:0048732 148 77 2,000 4,255E-03 0,02515968 ! T cell activation GO:0042110 134 79 2,000 4,573E-03 0,02696617 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 4,593E-03 0,02701895 ! fat cell differentiation GO:0045444 37 24 1,000 4,593E-03 0,02695002 ! response to toxin GO:0009636 38 24 1,000 4,593E-03 0,02688145 ! negative regulation of cell development GO:0010721 56 24 1,000 4,593E-03 0,02681322 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 4,593E-03 0,02674534 ! glutathione metabolic process GO:0006749 29 24 1,000 4,593E-03 0,0266778 ! protein localization in nucleus GO:0034504 133 80 2,000 4,736E-03 0,02744001 ! male gonad development GO:0008584 33 25 1,000 4,979E-03 0,02877319 ! regulation of peptide secretion GO:0002791 34 25 1,000 4,979E-03 0,02870108 ! regulation of chromosome organization GO:0033044 35 25 1,000 4,979E-03 0,02862933 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 4,979E-03 0,02855793 ! leukocyte proliferation GO:0070661 39 25 1,000 4,979E-03 0,02848689 GO:0032943|mononuclear cell proliferation, ! detection of stimulus GO:0051606 108 82 2,000 5,075E-03 0,02896214 ! regulation of cell adhesion GO:0030155 159 83 2,000 5,249E-03 0,02988371 ! regulation of pH GO:0006885 36 26 1,000 5,379E-03 0,03054867 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 5,379E-03 0,03047343 ! post-embryonic development GO:0009791 42 26 1,000 5,379E-03 0,03039856 ! regulation of defense response GO:0031347 117 84 2,000 5,427E-03 0,03059444 ! regulation of protein localization GO:0032880 132 85 2,000 5,609E-03 0,03154112 ! catechol metabolic process GO:0009712 43 27 1,000 5,794E-03 0,03250138 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 5,794E-03 0,0324223 ! skeletal muscle tissue development GO:0007519 123 87 2,000 5,983E-03 0,03340023 GO:0060538|skeletal muscle organ development, ! protein processing GO:0016485 114 88 2,000 6,176E-03 0,03439171 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 6,222E-03 0,03456885 ! phenol metabolic process GO:0018958 44 28 1,000 6,222E-03 0,03448555 ! cell junction assembly GO:0034329 56 28 1,000 6,222E-03 0,03440265 ! complement activation, classical pathway GO:0006958 36 28 1,000 6,222E-03 0,03432015 ! response to organic cyclic substance GO:0014070 47 28 1,000 6,222E-03 0,03423805 ! mesoderm formation GO:0001707 46 28 1,000 6,222E-03 0,03415633 ! positive regulation of catabolic process GO:0009896 40 28 1,000 6,222E-03 0,03407501 ! regulation of B cell activation GO:0050864 42 28 1,000 6,222E-03 0,03399407 ! reproductive developmental process GO:0003006 127 89 2,000 6,372E-03 0,03472774 ! response to hydrogen peroxide GO:0042542 42 29 1,000 6,665E-03 0,03624052 ! ovulation cycle process GO:0022602 41 29 1,000 6,665E-03 0,03615504 ! formation of primary germ layer GO:0001704 48 29 1,000 6,665E-03 0,03606997 ! eye morphogenesis GO:0048592 51 29 1,000 6,665E-03 0,0359853 ! tissue homeostasis GO:0001894 42 29 1,000 6,665E-03 0,03590103 GO:0048871|multicellular organismal homeostasis, ! positive regulation of immune response GO:0050778 121 92 2,000 6,983E-03 0,03752383 ! sulfur metabolic process GO:0006790 118 92 2,000 6,983E-03 0,03743636 ! collagen metabolic process GO:0032963 40 30 1,000 7,122E-03 0,038093 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 7,122E-03 0,03800461 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 7,122E-03 0,03791664 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 7,122E-03 0,03782907 ! ovulation cycle GO:0042698 43 30 1,000 7,122E-03 0,03774191 ! adult locomotory behavior GO:0008344 47 30 1,000 7,122E-03 0,03765515 ! response to heat GO:0009408 41 30 1,000 7,122E-03 0,03756878 ! DNA damage checkpoint GO:0000077 53 31 1,000 7,592E-03 0,03995875 ! odontogenesis GO:0042476 50 31 1,000 7,592E-03 0,03986752 ! segmentation GO:0035282 41 31 1,000 7,592E-03 0,0397767 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 7,592E-03 0,0396863 ! mesoderm morphogenesis GO:0048332 49 31 1,000 7,592E-03 0,03959631 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 7,592E-03 0,03950672 ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 7,592E-03 0,03941754 ! regulation of binding GO:0051098 151 95 2,000 7,627E-03 0,03951071 ! regulation of response to external stimulus GO:0032101 139 96 2,000 7,85E-03 0,04057152 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 7,85E-03 0,04048055 ! protein maturation GO:0051604 129 96 2,000 7,85E-03 0,04038999 ! regulation of muscle development GO:0048634 48 32 1,000 8,076E-03 0,04146296 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 8,076E-03 0,04137062 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 8,076E-03 0,04127868 ! regulation of protein stability GO:0031647 48 32 1,000 8,076E-03 0,04118716 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 8,076E-03 0,04109604 ! calcium ion transport GO:0006816 167 99 2,000 8,54E-03 0,04335911 ! protein import GO:0017038 156 99 2,000 8,54E-03 0,04326361 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 8,54E-03 0,04316852 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 8,574E-03 0,04324566 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 8,574E-03 0,04315103 ! ear morphogenesis GO:0042471 42 33 1,000 8,574E-03 0,04305681 ! cell junction organization GO:0034330 63 33 1,000 8,574E-03 0,04296301 ! nucleus organization GO:0006997 49 33 1,000 8,574E-03 0,04286961 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 8,574E-03 0,04277662 ! female gonad development GO:0008585 49 33 1,000 8,574E-03 0,04268403 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 8,574E-03 0,04259184 ! divalent metal ion transport GO:0070838 171 100 2,000 8,778E-03 0,04350959 ! protein localization in organelle GO:0033365 161 100 2,000 8,778E-03 0,04341602 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 9,085E-03 0,04484019 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 9,085E-03 0,04474418 ! female gamete generation GO:0007292 43 34 1,000 9,085E-03 0,04464857 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 9,085E-03 0,04455337 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 9,085E-03 0,04445857 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 9,609E-03 0,04692498 ! glycogen metabolic process GO:0005977 48 35 1,000 9,609E-03 0,04682556 ! pigment metabolic process GO:0042440 61 35 1,000 9,609E-03 0,04672656 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 9,609E-03 0,04662798 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01014702 0,04913294 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,01014702 0,04902972 ! regulation of hormone secretion GO:0046883 48 36 1,000 0,01014702 0,04892693 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,01014702 0,04882458 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,01014702 0,04872265 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,01014702 0,04862114 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,0106977 0,05115325 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 0,0106977 0,05104712 GO:0006956|complement activation, ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,01126134 0,05362543 ! gliogenesis GO:0042063 71 38 1,000 0,01126134 0,05351464 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,01183783 0,05613814 ! male sex differentiation GO:0046661 53 39 1,000 0,01183783 0,05602263 ! developmental growth GO:0048589 62 39 1,000 0,01183783 0,0559076 ! cell growth GO:0016049 61 39 1,000 0,01183783 0,05579303 ! response to calcium ion GO:0051592 58 40 1,000 0,01242704 0,05845029 ! peptide metabolic process GO:0006518 56 40 1,000 0,01242704 0,058331 ! double-strand break repair GO:0006302 67 40 1,000 0,01242704 0,0582122 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,01242704 0,05809388 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,01242704 0,05797605 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,01302887 0,06066071 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01302887 0,06053817 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,01364319 0,0632648 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,01364319 0,06313751 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,01364319 0,06301073 ! cellular component disassembly GO:0022411 64 42 1,000 0,01364319 0,06288445 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,01364319 0,06275868 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,01364319 0,06263342 ! positive regulation of binding GO:0051099 59 43 1,000 0,0142699 0,06538003 ! neuromuscular process GO:0050905 79 43 1,000 0,0142699 0,06525005 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,0142699 0,06512059 ! vesicle organization GO:0016050 79 43 1,000 0,0142699 0,06499164 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,01490889 0,06776767 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,01490889 0,067634 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,01556003 0,07044896 ! cell maturation GO:0048469 60 45 1,000 0,01556003 0,07031055 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 0,01556003 0,07017269 ! histone modification GO:0016570 68 46 1,000 0,01622322 0,07302039 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,01689836 0,07591058 ! covalent chromatin modification GO:0016569 75 47 1,000 0,01689836 0,07576261 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,01689836 0,07561521 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,01689836 0,07546839 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! response to temperature stimulus GO:0009266 62 48 1,000 0,01758532 0,07838416 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,01758532 0,07823255 ! gastrulation GO:0007369 73 48 1,000 0,01758532 0,07808152 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,01758532 0,07793107 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,01758532 0,0777812 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,01828399 0,08071629 ! germ cell development GO:0007281 68 49 1,000 0,01828399 0,08056166 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,01899428 0,08353126 ! lipid modification GO:0030258 73 50 1,000 0,01899428 0,08337185 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,01899428 0,08321305 ! positive regulation of secretion GO:0051047 71 51 1,000 0,01971607 0,08621097 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 0,01971607 0,08604738 ! muscle fiber development GO:0048747 74 51 1,000 0,01971607 0,08588441 ! adult behavior GO:0030534 80 51 1,000 0,01971607 0,08572206 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,01971607 0,08556032 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,02044926 0,08857494 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02098859 0,09074013 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02098859 0,09056989 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02098859 0,09040028 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02098859 0,09023131 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02098859 0,09006297 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02098859 0,08989525 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02098859 0,08972816 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02098859 0,08956169 ! sleep GO:0030431 11 5 0,000 0,02098859 0,08939584 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02098859 0,08923059 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02098859 0,08906596 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02098859 0,08890194 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02098859 0,08873851 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02098859 0,08857569 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02098859 0,08841346 ! tongue development GO:0043586 6 5 0,000 0,02098859 0,08825183 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02098859 0,08809079 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02098859 0,08793033 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02098859 0,08777046 ! cobalt ion transport GO:0006824 9 5 0,000 0,02098859 0,08761116 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02098859 0,08745245 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02098859 0,08729431 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02098859 0,08713674 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02098859 0,08697973 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02098859 0,08682329 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02098859 0,08666742 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02098859 0,0865121 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02098859 0,08635734 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02098859 0,08620313 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02098859 0,08604947 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02098859 0,08589636 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02098859 0,08574379 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02098859 0,08559176 ! malate metabolic process GO:0006108 7 5 0,000 0,02098859 0,08544027 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02098859 0,08528931 ! behavioral response to pain GO:0048266 7 5 0,000 0,02098859 0,08513889 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02098859 0,084989 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02098859 0,08483963 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02098859 0,08469079 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02098859 0,08454247 ! mating behavior GO:0007617 6 5 0,000 0,02098859 0,08439467 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02098859 0,08424739 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02098859 0,08410061 ! rhythmic behavior GO:0007622 12 5 0,000 0,02098859 0,08395435 ! copulation GO:0007620 7 5 0,000 0,02098859 0,0838086 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02098859 0,08366335 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02098859 0,0835186 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02098859 0,08337436 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02098859 0,08323061 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02098859 0,08308735 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02098859 0,08294459 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02098859 0,08280232 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02098859 0,08266053 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02098859 0,08251923 ! response to protozoan GO:0001562 9 5 0,000 0,02098859 0,08237842 ! lymph vessel development GO:0001945 7 5 0,000 0,02098859 0,08223808 ! endochondral ossification GO:0001958 12 5 0,000 0,02098859 0,08209822 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02098859 0,08195883 ! parathyroid gland development GO:0060017 8 5 0,000 0,02098859 0,08181992 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02098859 0,08168148 ! anagen GO:0042640 6 5 0,000 0,02098859 0,0815435 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02098859 0,08140599 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02098859 0,08126894 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02098859 0,08113236 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02098859 0,08099623 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02098859 0,08086056 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02098859 0,08072534 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02098859 0,08059057 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02098859 0,08045625 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02098859 0,08032238 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02098859 0,08018896 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02098859 0,08005597 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02098859 0,07992343 ! ovulation GO:0030728 6 5 0,000 0,02098859 0,07979133 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02098859 0,07965966 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02098859 0,07952842 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,02098859 0,07939762 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02098859 0,07926724 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02098859 0,0791373 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02098859 0,07900778 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02098859 0,07887868 ! polyol catabolic process GO:0046174 7 5 0,000 0,02098859 0,07875 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02098859 0,07862175 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02098859 0,07849391 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02098859 0,07836648 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02098859 0,07823947 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02098859 0,07811287 ! urea metabolic process GO:0019627 6 5 0,000 0,02098859 0,07798667 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02098859 0,07786089 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02098859 0,07773551 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02098859 0,07761053 ! neutrophil activation GO:0042119 5 5 0,000 0,02098859 0,07748596 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02098859 0,07736178 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02098859 0,077238 ! response to food GO:0032094 5 5 0,000 0,02098859 0,07711462 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02098859 0,07699163 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02098859 0,07686903 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02098859 0,07674682 ! forebrain neuron development GO:0021884 7 5 0,000 0,02098859 0,076625 ! melanosome organization GO:0032438 7 5 0,000 0,02098859 0,07650357 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02098859 0,07638252 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02098859 0,07626185 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02098859 0,07614156 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02098859 0,07602166 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02098859 0,07590213 ! nucleoside transport GO:0015858 6 5 0,000 0,02098859 0,07578297 ! nucleoside salvage GO:0043174 7 5 0,000 0,02098859 0,07566419 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02098859 0,07554578 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02098859 0,07542774 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02098859 0,07531007 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02098859 0,07519276 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02098859 0,07507582 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02098859 0,07495924 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02098859 0,07484303 ! depyrimidination GO:0045008 8 5 0,000 0,02098859 0,07472717 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02098859 0,07461167 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02098859 0,07449653 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02098859 0,07438174 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02098859 0,07426731 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02098859 0,07415323 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02098859 0,0740395 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02098859 0,07392611 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02098859 0,07381308 ! monocyte differentiation GO:0030224 8 5 0,000 0,02098859 0,07370038 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02098859 0,07358804 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02098859 0,07347603 ! centrosome duplication GO:0051298 5 5 0,000 0,02098859 0,07336436 ! response to UV-C GO:0010225 6 5 0,000 0,02098859 0,07325304 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02098859 0,07314205 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02098859 0,07303139 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02098859 0,07292108 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02098859 0,07281109 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02098859 0,07270143 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02098859 0,07259211 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02098859 0,07248311 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02098859 0,07237444 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02098859 0,0722661 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02098859 0,07215807 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02098859 0,07205038 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02098859 0,071943 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02098859 0,07183594 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02098859 0,0717292 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02098859 0,07162278 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02098859 0,07151667 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02098859 0,07141088 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02098859 0,07130539 ! neural tube patterning GO:0021532 6 5 0,000 0,02098859 0,07120022 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02098859 0,07109536 ! histone demethylation GO:0016577 9 5 0,000 0,02098859 0,07099081 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02098859 0,07088657 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02098859 0,07078263 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02098859 0,07067899 ! enteric nervous system development GO:0048484 8 5 0,000 0,02098859 0,07057566 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02098859 0,07047263 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02098859 0,0703699 ! transcription termination GO:0006353 8 5 0,000 0,02098859 0,07026747 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02098859 0,07016534 ! plasminogen activation GO:0031639 5 5 0,000 0,02098859 0,0700635 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02098859 0,06996196 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02098859 0,06986071 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02098859 0,06975976 GO:0015991|ATP hydrolysis coupled proton transport, ! protein destabilization GO:0031648 6 5 0,000 0,02098859 0,06965909 ! apical protein localization GO:0045176 6 5 0,000 0,02098859 0,06955872 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02098859 0,06945864 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02098859 0,06935884 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02098859 0,06925933 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02098859 0,0691601 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02098859 0,06906116 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02098859 0,0689625 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02098859 0,06886413 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02098859 0,06876603 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02098859 0,06866821 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02098859 0,06857067 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02098859 0,06847341 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02098859 0,06837642 ! neural plate development GO:0001840 6 5 0,000 0,02098859 0,06827971 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02098859 0,06818327 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02098859 0,0680871 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02098859 0,0679912 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02098859 0,06789557 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02098859 0,06780021 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02098859 0,06770512 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02098859 0,0676103 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02098859 0,06751574 ! spindle assembly GO:0051225 5 5 0,000 0,02098859 0,06742144 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02098859 0,06732741 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02098859 0,06723364 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02098859 0,06714013 ! organ regeneration GO:0031100 7 5 0,000 0,02098859 0,06704688 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02098859 0,06695389 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02098859 0,06686115 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02098859 0,06676867 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02098859 0,06667645 GO:0055081|anion homeostasis, ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,02194939 0,06963254 ! DNA catabolic process GO:0006308 67 54 1,000 0,02194939 0,06953663 ! mesoderm development GO:0007498 76 55 1,000 0,02271612 0,07186668 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,02349382 0,074225 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,0242824 0,07661113 GO:0048609|reproductive process in a multicellular organism, ! secondary metabolic process GO:0019748 84 57 1,000 0,0242824 0,07650619 ! developmental maturation GO:0021700 75 57 1,000 0,0242824 0,07640153 ! gonad development GO:0008406 79 57 1,000 0,0242824 0,07629715 ! viral reproductive process GO:0022415 87 58 1,000 0,02508174 0,07870122 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,02508174 0,078594 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,02508174 0,07848707 ! tRNA transcription GO:0009304 11 6 0,000 0,02513386 0,0785433 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02513386 0,07843673 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02513386 0,07833044 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02513386 0,07822445 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02513386 0,07811874 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02513386 0,07801332 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02513386 0,07790818 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,02513386 0,07780332 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02513386 0,07769875 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02513386 0,07759445 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02513386 0,07749044 ! prostate gland development GO:0030850 9 6 0,000 0,02513386 0,0773867 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02513386 0,07728325 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02513386 0,07718006 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02513386 0,07707716 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02513386 0,07697452 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02513386 0,07687216 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02513386 0,07677008 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02513386 0,07666826 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02513386 0,07656671 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02513386 0,07646543 ! neuron adhesion GO:0007158 9 6 0,000 0,02513386 0,07636442 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02513386 0,07626368 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02513386 0,0761632 ! signal peptide processing GO:0006465 8 6 0,000 0,02513386 0,07606298 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02513386 0,07596303 ! mRNA stabilization GO:0048255 15 6 0,000 0,02513386 0,07586334 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02513386 0,07576392 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02513386 0,07566475 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02513386 0,07556584 ! opsonization GO:0008228 8 6 0,000 0,02513386 0,07546719 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02513386 0,0753688 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02513386 0,07527066 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02513386 0,07517278 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02513386 0,07507515 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02513386 0,07497778 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02513386 0,07488066 GO:0046530|photoreceptor cell differentiation, ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02513386 0,07478379 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02513386 0,07468717 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02513386 0,0745908 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02513386 0,07449467 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02513386 0,0743988 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02513386 0,07430317 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02513386 0,07420779 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02513386 0,07411265 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02513386 0,07401776 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02513386 0,0739231 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02513386 0,07382869 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02513386 0,07373452 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02513386 0,0736406 ! thymic T cell selection GO:0045061 12 6 0,000 0,02513386 0,07354691 ! protein lipoylation GO:0009249 10 6 0,000 0,02513386 0,07345345 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02513386 0,07336024 ! drug transport GO:0015893 6 6 0,000 0,02513386 0,07326726 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02513386 0,07317452 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02513386 0,07308201 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02513386 0,07298973 ! histidine metabolic process GO:0006547 6 6 0,000 0,02513386 0,07289769 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02513386 0,07280588 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02513386 0,0727143 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 0,02513386 0,07262295 ! adenohypophysis development GO:0021984 10 6 0,000 0,02513386 0,07253183 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02513386 0,07244094 ! hyperosmotic response GO:0006972 8 6 0,000 0,02513386 0,07235027 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02513386 0,07225983 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02513386 0,07216962 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02513386 0,07207964 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02513386 0,07198987 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02513386 0,07190033 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02513386 0,07181102 ! response to dietary excess GO:0002021 7 6 0,000 0,02513386 0,07172192 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02513386 0,07163305 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02513386 0,07154439 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02513386 0,07145595 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02513386 0,07136774 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02513386 0,07127974 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02513386 0,07119196 ! neuron apoptosis GO:0051402 8 6 0,000 0,02513386 0,07110439 ! organic alcohol transport GO:0015850 9 6 0,000 0,02513386 0,07101704 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02513386 0,0709299 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02513386 0,07084297 ! carnitine transport GO:0015879 8 6 0,000 0,02513386 0,07075626 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02513386 0,07066976 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02513386 0,07058348 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02513386 0,0704974 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02513386 0,07041153 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02513386 0,07032587 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02513386 0,07024042 ! parturition GO:0007567 12 6 0,000 0,02513386 0,07015518 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02513386 0,07007014 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02513386 0,06998531 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02513386 0,06990069 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02513386 0,06981627 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02513386 0,06973205 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02513386 0,06964803 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02513386 0,06956422 ! astrocyte development GO:0014002 14 6 0,000 0,02513386 0,06948061 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02513386 0,0693972 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02513386 0,06931399 ! interaction with symbiont GO:0051702 8 6 0,000 0,02513386 0,06923098 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02513386 0,06914817 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02513386 0,06906555 ! eating behavior GO:0042755 6 6 0,000 0,02513386 0,06898314 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02513386 0,06890091 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02513386 0,06881889 ! response to copper ion GO:0046688 9 6 0,000 0,02513386 0,06873706 ! DNA topological change GO:0006265 8 6 0,000 0,02513386 0,06865542 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02513386 0,06857398 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02513386 0,06849273 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02513386 0,06841168 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02513386 0,06833081 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02513386 0,06825014 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02513386 0,06816966 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02513386 0,06808936 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02513386 0,06800926 ! gas homeostasis GO:0033483 11 6 0,000 0,02513386 0,06792934 ! hair follicle maturation GO:0048820 7 6 0,000 0,02513386 0,06784961 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02513386 0,06777007 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02513386 0,06769071 ! Schwann cell development GO:0014044 14 6 0,000 0,02513386 0,06761154 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02513386 0,06753256 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02513386 0,06745375 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02513386 0,06737514 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02513386 0,0672967 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02513386 0,06721845 ! histone ubiquitination GO:0016574 7 6 0,000 0,02513386 0,06714038 ! regulation of meiosis GO:0040020 10 6 0,000 0,02513386 0,06706249 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02513386 0,06698478 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02513386 0,06690725 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02513386 0,0668299 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02513386 0,06675273 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02513386 0,06667574 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02513386 0,06659893 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02513386 0,06652229 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02513386 0,06644582 ! receptor internalization GO:0031623 9 6 0,000 0,02513386 0,06636954 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02513386 0,06629343 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02513386 0,06621749 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02513386 0,06614172 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 8 6 0,000 0,02513386 0,06606613 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02513386 0,06599072 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02513386 0,06591547 ! axonal fasciculation GO:0007413 9 6 0,000 0,02513386 0,0658404 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02513386 0,06576549 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02513386 0,06569076 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02513386 0,06561619 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02513386 0,0655418 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02513386 0,06546757 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02513386 0,06539352 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02513386 0,06531962 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02513386 0,0652459 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02513386 0,06517234 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02513386 0,06509895 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02513386 0,06502572 ! adult feeding behavior GO:0008343 6 6 0,000 0,02513386 0,06495266 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02513386 0,06487976 ! blastocyst growth GO:0001832 15 6 0,000 0,02513386 0,06480703 ! pigment granule transport GO:0051904 12 6 0,000 0,02513386 0,06473445 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02513386 0,06466204 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02513386 0,0645898 ! catecholamine transport GO:0051937 7 6 0,000 0,02513386 0,06451771 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02513386 0,06444578 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02513386 0,06437402 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02513386 0,06430241 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02513386 0,06423096 ! protein prenylation GO:0018342 10 6 0,000 0,02513386 0,06415968 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02513386 0,06408854 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02513386 0,06401757 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02513386 0,06394676 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02513386 0,0638761 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02513386 0,06380559 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,02589174 0,06565711 ! actin filament organization GO:0007015 95 59 1,000 0,02589174 0,0655848 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,0267123 0,06758887 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,02754332 0,06961498 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,02754332 0,06953857 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,02754332 0,06946232 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,0283847 0,07150581 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,02923634 0,07357065 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,02923634 0,07349024 ! viral reproduction GO:0016032 92 63 1,000 0,02923634 0,07341001 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,02926181 0,07339385 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02926181 0,0733139 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02926181 0,07323412 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02926181 0,07315452 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02926181 0,07307509 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02926181 0,07299583 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02926181 0,07291675 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02926181 0,07283783 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02926181 0,07275909 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02926181 0,07268052 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02926181 0,07260211 ! reproductive behavior GO:0019098 12 7 0,000 0,02926181 0,07252388 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02926181 0,07244581 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02926181 0,07236791 ! oligopeptide transport GO:0006857 11 7 0,000 0,02926181 0,07229018 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02926181 0,07221262 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02926181 0,07213522 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,02926181 0,07205798 ! RNA methylation GO:0001510 11 7 0,000 0,02926181 0,07198092 ! pericardium development GO:0060039 8 7 0,000 0,02926181 0,07190401 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02926181 0,07182728 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02926181 0,0717507 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02926181 0,07167429 ! lipoprotein transport GO:0042953 9 7 0,000 0,02926181 0,07159804 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02926181 0,07152195 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02926181 0,07144603 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02926181 0,07137026 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02926181 0,07129466 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02926181 0,07121921 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02926181 0,07114393 ! chemosensory behavior GO:0007635 9 7 0,000 0,02926181 0,0710688 ! microtubule bundle formation GO:0001578 8 7 0,000 0,02926181 0,07099384 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02926181 0,07091903 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02926181 0,07084438 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02926181 0,07076988 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02926181 0,07069554 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02926181 0,07062136 ! reflex GO:0060004 12 7 0,000 0,02926181 0,07054734 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02926181 0,07047346 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02926181 0,07039975 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02926181 0,07032618 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02926181 0,07025277 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02926181 0,07017952 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02926181 0,07010641 ! spinal cord patterning GO:0021511 7 7 0,000 0,02926181 0,07003346 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02926181 0,06996066 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02926181 0,06988801 ! adrenal gland development GO:0030325 17 7 0,000 0,02926181 0,06981552 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02926181 0,06974317 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02926181 0,06967097 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02926181 0,06959892 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02926181 0,06952702 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02926181 0,06945527 ! endosome organization GO:0007032 10 7 0,000 0,02926181 0,06938367 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02926181 0,06931221 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,02926181 0,0692409 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02926181 0,06916974 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02926181 0,06909872 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02926181 0,06902785 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02926181 0,06895713 ! galactose metabolic process GO:0006012 10 7 0,000 0,02926181 0,06888655 ! vesicle fusion GO:0006906 15 7 0,000 0,02926181 0,06881611 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02926181 0,06874582 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02926181 0,06867567 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02926181 0,06860567 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02926181 0,0685358 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02926181 0,06846608 ! retinol metabolic process GO:0042572 9 7 0,000 0,02926181 0,0683965 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,02926181 0,06832706 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02926181 0,06825777 ! rRNA modification GO:0000154 12 7 0,000 0,02926181 0,06818861 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02926181 0,06811959 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02926181 0,06805072 ! intermediate filament organization GO:0045109 11 7 0,000 0,02926181 0,06798198 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02926181 0,06791338 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02926181 0,06784492 ! fibrinolysis GO:0042730 9 7 0,000 0,02926181 0,06777659 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02926181 0,06770841 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02926181 0,06764036 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02926181 0,06757245 ! response to tropane GO:0014073 13 7 0,000 0,02926181 0,06750467 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02926181 0,06743703 ! melanosome localization GO:0032400 10 7 0,000 0,02926181 0,06736953 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02926181 0,06730216 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02926181 0,06723492 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02926181 0,06716782 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02926181 0,06710086 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02926181 0,06703402 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02926181 0,06696732 ! mast cell activation GO:0045576 9 7 0,000 0,02926181 0,06690075 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02926181 0,06683432 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02926181 0,06676801 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02926181 0,06670184 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02926181 0,0666358 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02926181 0,06656989 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02926181 0,06650411 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02926181 0,06643846 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02926181 0,06637294 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02926181 0,06630754 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02926181 0,06624228 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02926181 0,06617715 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02926181 0,06611214 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02926181 0,06604726 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02926181 0,06598251 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02926181 0,06591788 ! diuresis GO:0030146 12 7 0,000 0,02926181 0,06585338 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02926181 0,06578901 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02926181 0,06572476 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02926181 0,06566064 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02926181 0,06559665 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02926181 0,06553277 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02926181 0,06546903 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02926181 0,0654054 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02926181 0,0653419 ! lymph node development GO:0048535 9 7 0,000 0,02926181 0,06527852 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02926181 0,06521527 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,02926181 0,06515214 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02926181 0,06508913 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02926181 0,06502624 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02926181 0,06496347 ! ATP catabolic process GO:0006200 10 7 0,000 0,02926181 0,06490083 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02926181 0,0648383 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02926181 0,0647759 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02926181 0,06471361 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02926181 0,06465145 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02926181 0,0645894 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02926181 0,06452748 ! muscle adaptation GO:0043500 12 7 0,000 0,02926181 0,06446567 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02926181 0,06440398 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02926181 0,06434241 ! retina homeostasis GO:0001895 9 7 0,000 0,02926181 0,06428095 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02926181 0,06421962 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02926181 0,0641584 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,02926181 0,06409729 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02926181 0,06403631 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02926181 0,06397544 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02926181 0,06391468 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02926181 0,06385404 ! adaptive immune response GO:0002250 94 64 1,000 0,03009813 0,06561678 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 1,000 0,03096999 0,06745358 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,03096999 0,06738976 ! activation of immune response GO:0002253 83 65 1,000 0,03096999 0,06732606 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,03185181 0,06917768 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,03274349 0,0710472 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03337252 0,07234381 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03337252 0,07227569 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,03337252 0,0722077 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03337252 0,07213984 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03337252 0,0720721 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03337252 0,07200449 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03337252 0,07193701 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03337252 0,07186965 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03337252 0,07180242 ! phosphate transport GO:0006817 10 8 0,000 0,03337252 0,07173531 ! N-glycan processing GO:0006491 12 8 0,000 0,03337252 0,07166834 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03337252 0,07160148 ! UTP metabolic process GO:0046051 8 8 0,000 0,03337252 0,07153475 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03337252 0,07146814 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03337252 0,07140166 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03337252 0,0713353 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03337252 0,07126907 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03337252 0,07120296 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03337252 0,07113697 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03337252 0,0710711 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03337252 0,07100535 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03337252 0,07093973 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03337252 0,07087423 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03337252 0,07080884 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03337252 0,07074358 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03337252 0,07067844 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03337252 0,07061342 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03337252 0,07054852 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03337252 0,07048373 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03337252 0,07041907 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03337252 0,07035453 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03337252 0,0702901 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03337252 0,07022579 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03337252 0,0701616 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03337252 0,07009752 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03337252 0,07003356 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03337252 0,06996972 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03337252 0,069906 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,03337252 0,06984239 ! macrophage activation GO:0042116 12 8 0,000 0,03337252 0,0697789 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03337252 0,06971552 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03337252 0,06965226 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,03337252 0,06958911 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03337252 0,06952608 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03337252 0,06946316 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03337252 0,06940035 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03337252 0,06933766 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03337252 0,06927508 ! ruffle organization GO:0031529 11 8 0,000 0,03337252 0,06921261 ! osteoblast development GO:0002076 13 8 0,000 0,03337252 0,06915026 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03337252 0,06908802 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03337252 0,06902589 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03337252 0,06896387 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03337252 0,06890196 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03337252 0,06884017 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03337252 0,06877848 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03337252 0,06871691 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03337252 0,06865544 ! brain morphogenesis GO:0048854 20 8 0,000 0,03337252 0,06859409 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03337252 0,06853285 ! segment specification GO:0007379 10 8 0,000 0,03337252 0,06847171 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03337252 0,06841068 ! cellular extravasation GO:0045123 11 8 0,000 0,03337252 0,06834977 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03337252 0,06828896 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03337252 0,06822825 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03337252 0,06816766 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,03337252 0,06810718 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03337252 0,0680468 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03337252 0,06798653 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03337252 0,06792636 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03337252 0,0678663 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03337252 0,06780635 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03337252 0,0677465 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03337252 0,06768676 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03337252 0,06762712 ! icosanoid secretion GO:0032309 12 8 0,000 0,03337252 0,06756759 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,03337252 0,06750817 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03337252 0,06744885 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03337252 0,06738963 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03337252 0,06733051 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03337252 0,0672715 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03337252 0,0672126 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03337252 0,06715379 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03337252 0,06709509 ! sterol catabolic process GO:0016127 9 8 0,000 0,03337252 0,0670365 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03337252 0,066978 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03337252 0,0669196 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03337252 0,06686131 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03337252 0,06680312 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03337252 0,06674503 ! prophase GO:0051324 11 8 0,000 0,03337252 0,06668704 ! S phase GO:0051320 8 8 0,000 0,03337252 0,06662916 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03337252 0,06657137 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03337252 0,06651368 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03337252 0,06645609 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03337252 0,0663986 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03337252 0,06634122 ! hormone catabolic process GO:0042447 13 8 0,000 0,03337252 0,06628393 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03337252 0,06622674 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03337252 0,06616964 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03337252 0,06611265 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03337252 0,06605575 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03337252 0,06599896 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03337252 0,06594226 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03337252 0,06588565 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03337252 0,06582915 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03337252 0,06577274 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03337252 0,06571643 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03337252 0,06566021 ! mitochondrion localization GO:0051646 12 8 0,000 0,03337252 0,06560409 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,03337252 0,06554807 ! acute inflammatory response GO:0002526 92 68 1,000 0,03364495 0,06602677 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,03364495 0,06597048 ! rhythmic process GO:0048511 105 68 1,000 0,03364495 0,06591429 ! regulation of catabolic process GO:0009894 106 70 1,000 0,03547677 0,06944389 ! muscle cell differentiation GO:0042692 104 71 1,000 0,03640695 0,07120407 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,03640695 0,07114357 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,03746605 0,07315103 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03746605 0,07308899 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,03746605 0,07302705 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03746605 0,07296521 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03746605 0,07290348 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,03746605 0,07284186 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,03746605 0,07278034 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03746605 0,07271892 ! GTP metabolic process GO:0046039 9 9 0,000 0,03746605 0,0726576 ! elastic fiber assembly GO:0048251 13 9 0,000 0,03746605 0,07259639 ! social behavior GO:0035176 14 9 0,000 0,03746605 0,07253528 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03746605 0,07247428 ! artery development GO:0060840 19 9 0,000 0,03746605 0,07241338 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03746605 0,07235258 ! response to pain GO:0048265 16 9 0,000 0,03746605 0,07229188 ! protein complex disassembly GO:0043241 17 9 0,000 0,03746605 0,07223128 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03746605 0,07217079 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,03746605 0,07211039 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,03746605 0,0720501 ! lung alveolus development GO:0048286 17 9 0,000 0,03746605 0,07198991 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03746605 0,07192981 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03746605 0,07186982 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03746605 0,07180993 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03746605 0,07175014 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03746605 0,07169045 ! protein targeting to ER GO:0045047 19 9 0,000 0,03746605 0,07163085 ! endoderm development GO:0007492 12 9 0,000 0,03746605 0,07157136 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03746605 0,07151196 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,03746605 0,07145267 ! arginine catabolic process GO:0006527 10 9 0,000 0,03746605 0,07139347 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03746605 0,07133437 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,03746605 0,07127537 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,03746605 0,07121646 ! V(D)J recombination GO:0033151 12 9 0,000 0,03746605 0,07115765 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03746605 0,07109894 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03746605 0,07104033 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03746605 0,07098181 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,03746605 0,07092339 ! mannose metabolic process GO:0006013 9 9 0,000 0,03746605 0,07086506 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,03746605 0,07080683 ! receptor clustering GO:0043113 15 9 0,000 0,03746605 0,0707487 ! epithelial cell development GO:0002064 10 9 0,000 0,03746605 0,07069066 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03746605 0,07063272 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03746605 0,07057487 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03746605 0,07051712 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03746605 0,07045946 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03746605 0,07040189 ! motor axon guidance GO:0008045 14 9 0,000 0,03746605 0,07034442 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,03746605 0,07028705 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03746605 0,07022976 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03746605 0,07017257 ! DNA ligation GO:0006266 14 9 0,000 0,03746605 0,07011547 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03746605 0,07005847 ! response to amine stimulus GO:0014075 13 9 0,000 0,03746605 0,07000156 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03746605 0,06994474 ! erythrocyte development GO:0048821 11 9 0,000 0,03746605 0,06988801 ! renal water homeostasis GO:0003091 14 9 0,000 0,03746605 0,06983138 ! postreplication repair GO:0006301 11 9 0,000 0,03746605 0,06977483 ! mRNA cleavage GO:0006379 13 9 0,000 0,03746605 0,06971838 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03746605 0,06966202 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03746605 0,06960575 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03746605 0,06954957 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03746605 0,06949348 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,03746605 0,06943748 ! acid secretion GO:0046717 14 9 0,000 0,03746605 0,06938158 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03746605 0,06932576 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03746605 0,06927003 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03746605 0,06921439 ! purine base metabolic process GO:0006144 18 9 0,000 0,03746605 0,06915884 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03746605 0,06910338 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03746605 0,06904801 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03746605 0,06899273 ! detection of calcium ion GO:0005513 13 9 0,000 0,03746605 0,06893753 ! blastocyst formation GO:0001825 12 9 0,000 0,03746605 0,06888243 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,03746605 0,06882741 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03746605 0,06877248 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,03746605 0,06871764 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,03746605 0,06866288 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03746605 0,06860821 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03746605 0,06855363 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03746605 0,06849914 ! prepulse inhibition GO:0060134 14 9 0,000 0,03746605 0,06844473 ! embryonic placenta development GO:0001892 12 9 0,000 0,03746605 0,06839041 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,03746605 0,06833618 ! insulin secretion GO:0030073 17 9 0,000 0,03746605 0,06828203 ! sequestering of metal ion GO:0051238 11 9 0,000 0,03746605 0,06822796 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03746605 0,06817399 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03746605 0,06812009 ! localization within membrane GO:0051668 15 9 0,000 0,03746605 0,06806629 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,03829538 0,06951805 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,03925344 0,07120104 ! amine biosynthetic process GO:0009309 97 76 1,000 0,04119679 0,07466716 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,04119679 0,07460836 ! regulation of protein transport GO:0051223 114 76 1,000 0,04119679 0,07454966 GO:0070201|regulation of establishment of protein localization, ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04154248 0,07511613 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04154248 0,07505712 ! neuron fate specification GO:0048665 11 10 0,000 0,04154248 0,07499821 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04154248 0,07493938 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,04154248 0,07488065 ! thyroid gland development GO:0030878 19 10 0,000 0,04154248 0,07482202 ! synapsis GO:0007129 13 10 0,000 0,04154248 0,07476347 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04154248 0,07470501 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,04154248 0,07464665 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04154248 0,07458838 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,04154248 0,0745302 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,04154248 0,07447211 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,04154248 0,07441411 ! phospholipid efflux GO:0033700 16 10 0,000 0,04154248 0,0743562 ! hippocampus development GO:0021766 19 10 0,000 0,04154248 0,07429838 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,04154248 0,07424065 ! blood vessel remodeling GO:0001974 21 10 0,000 0,04154248 0,07418301 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04154248 0,07412546 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,04154248 0,07406799 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,04154248 0,07401062 ! pathogenesis GO:0009405 13 10 0,000 0,04154248 0,07395334 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04154248 0,07389614 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04154248 0,07383904 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04154248 0,07378202 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,04154248 0,07372509 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,04154248 0,07366824 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04154248 0,07361149 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04154248 0,07355482 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,04154248 0,07349824 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04154248 0,07344175 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04154248 0,07338534 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04154248 0,07332902 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04154248 0,07327279 ! forebrain cell migration GO:0021885 17 10 0,000 0,04154248 0,07321664 ! lipid digestion GO:0044241 15 10 0,000 0,04154248 0,07316058 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04154248 0,0731046 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04154248 0,07304871 ! UV protection GO:0009650 14 10 0,000 0,04154248 0,07299291 ! entry into host cell GO:0030260 20 10 0,000 0,04154248 0,07293719 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04154248 0,07288155 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,04154248 0,072826 ! regulation of bone resorption GO:0045124 24 10 0,000 0,04154248 0,07277054 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04154248 0,07271515 ! regulation of organ growth GO:0046620 11 10 0,000 0,04154248 0,07265986 ! response to dsRNA GO:0043331 18 10 0,000 0,04154248 0,07260465 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,04154248 0,07254952 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,04154248 0,07249447 ! embryonic axis specification GO:0000578 12 10 0,000 0,04154248 0,07243951 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,04154248 0,07238463 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04154248 0,07232984 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04154248 0,07227512 ! cranial nerve development GO:0021545 12 10 0,000 0,04154248 0,07222049 ! fucose catabolic process GO:0019317 16 10 0,000 0,04154248 0,07216595 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,04154248 0,07211148 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04154248 0,0720571 ! protein sumoylation GO:0016925 12 10 0,000 0,04154248 0,0720028 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04154248 0,07194858 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04154248 0,07189444 ! zymogen activation GO:0031638 14 10 0,000 0,04154248 0,07184039 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04154248 0,07178641 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04154248 0,07173252 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04154248 0,0716787 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04154248 0,07162497 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,04154248 0,07157132 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,04154248 0,07151775 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,04154248 0,07146426 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04154248 0,07141085 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04154248 0,07135752 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04154248 0,07130426 ! detection of bacterium GO:0016045 10 10 0,000 0,04154248 0,07125109 ! embryonic gut development GO:0048566 11 10 0,000 0,04154248 0,071198 ! activation of innate immune response GO:0002218 10 10 0,000 0,04154248 0,07114498 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04154248 0,07109205 ! developmental induction GO:0031128 13 10 0,000 0,04154248 0,07103919 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,04154248 0,07098641 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,04154248 0,07093371 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04154248 0,07088109 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,04154248 0,07082855 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,0421819 0,07186546 ! regulation of DNA binding GO:0051101 119 77 1,000 0,0421819 0,07181226 ! sex differentiation GO:0007548 105 77 1,000 0,0421819 0,07175915 ! protein ubiquitination GO:0016567 125 77 1,000 0,0421819 0,07170611 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,04317584 0,07334153 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,04417852 0,07498937 ! regulation of lyase activity GO:0051339 133 79 1,000 0,04417852 0,07493407 ! rRNA transcription GO:0009303 17 11 0,000 0,04560189 0,07729133 ! respiratory burst GO:0045730 14 11 0,000 0,04560189 0,07723442 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04560189 0,07717758 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04560189 0,07712084 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04560189 0,07706417 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,04560189 0,07700759 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,04560189 0,07695109 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04560189 0,07689467 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04560189 0,07683834 ! mating GO:0007618 14 11 0,000 0,04560189 0,07678209 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,04560189 0,07672592 ! T cell proliferation GO:0042098 20 11 0,000 0,04560189 0,07666984 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,04560189 0,07661383 ! bone resorption GO:0045453 16 11 0,000 0,04560189 0,07655791 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04560189 0,07650207 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04560189 0,07644631 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04560189 0,07639063 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,04560189 0,07633503 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04560189 0,07627952 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04560189 0,07622408 ! syncytium formation GO:0006949 15 11 0,000 0,04560189 0,07616873 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04560189 0,07611345 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04560189 0,07605826 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04560189 0,07600314 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04560189 0,07594811 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04560189 0,07589315 ! adult heart development GO:0007512 11 11 0,000 0,04560189 0,07583828 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,04560189 0,07578348 ! temperature homeostasis GO:0001659 16 11 0,000 0,04560189 0,07572876 ! L-glutamate transport GO:0015813 16 11 0,000 0,04560189 0,07567412 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04560189 0,07561956 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04560189 0,07556508 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04560189 0,07551068 ! stem cell development GO:0048864 29 11 0,000 0,04560189 0,07545636 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04560189 0,07540211 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04560189 0,07534794 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,04560189 0,07529385 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04560189 0,07523984 ! vasoconstriction GO:0042310 15 11 0,000 0,04560189 0,0751859 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04560189 0,07513205 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04560189 0,07507826 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04560189 0,07502456 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04560189 0,07497093 ! ribosome assembly GO:0042255 13 11 0,000 0,04560189 0,07491738 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04560189 0,07486391 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04560189 0,07481051 ! chromatin silencing GO:0006342 19 11 0,000 0,04560189 0,07475719 ! nucleosome positioning GO:0016584 13 11 0,000 0,04560189 0,07470394 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04560189 0,07465077 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,04560189 0,07459768 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04560189 0,07454466 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04560189 0,07449172 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04560189 0,07443885 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04560189 0,07438605 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04560189 0,07433334 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04560189 0,07428069 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04560189 0,07422812 ! male genitalia development GO:0030539 13 11 0,000 0,04560189 0,07417563 ! cholesterol efflux GO:0033344 19 11 0,000 0,04560189 0,07412321 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04560189 0,07407086 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04560189 0,07401859 ! germ cell migration GO:0008354 18 11 0,000 0,04560189 0,07396639 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04560189 0,07391426 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,04560189 0,07386221 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,04560189 0,07381023 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04560189 0,07375832 ! lysogeny GO:0030069 18 11 0,000 0,04560189 0,07370649 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04560189 0,07365473 ! acrosome reaction GO:0007340 13 11 0,000 0,04560189 0,07360304 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04560189 0,07355143 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,04620976 0,07447964 ! response to protein stimulus GO:0051789 111 81 1,000 0,04620976 0,07442749 ! regulation of neurological system process GO:0031644 122 81 1,000 0,04620976 0,0743754 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,04620976 0,07432339 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,0482749 0,07759069 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,0482749 0,07753651 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,04931997 0,07915976 ! lactation GO:0007595 20 12 0,000 0,04964432 0,07962479 ! reproductive cellular process GO:0048610 14 12 0,000 0,04964432 0,0795693 ! tRNA modification GO:0006400 14 12 0,000 0,04964432 0,07951389 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04964432 0,07945856 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04964432 0,0794033 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04964432 0,07934812 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,04964432 0,07929302 ! non-recombinational repair GO:0000726 19 12 0,000 0,04964432 0,07923799 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04964432 0,07918304 ! peroxisomal transport GO:0043574 21 12 0,000 0,04964432 0,07912817 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,04964432 0,07907337 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04964432 0,07901865 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04964432 0,078964 ! heart looping GO:0001947 15 12 0,000 0,04964432 0,07890943 ! palate development GO:0060021 15 12 0,000 0,04964432 0,07885494 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04964432 0,07880052 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04964432 0,07874617 ! arginine metabolic process GO:0006525 13 12 0,000 0,04964432 0,0786919 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04964432 0,0786377 ! methionine metabolic process GO:0006555 13 12 0,000 0,04964432 0,07858358 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04964432 0,07852954 ! Golgi organization GO:0007030 18 12 0,000 0,04964432 0,07847556 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,04964432 0,07842167 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,04964432 0,07836784 ! monoamine transport GO:0015844 13 12 0,000 0,04964432 0,07831409 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04964432 0,07826042 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04964432 0,07820681 ! L-amino acid transport GO:0015807 20 12 0,000 0,04964432 0,07815328 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04964432 0,07809983 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04964432 0,07804644 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04964432 0,07799313 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04964432 0,0779399 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04964432 0,07788673 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04964432 0,07783364 ! cerebellum development GO:0021549 13 12 0,000 0,04964432 0,07778062 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04964432 0,07772767 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,04964432 0,07767479 ! histone methylation GO:0016571 15 12 0,000 0,04964432 0,07762199 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04964432 0,07756926 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04964432 0,0775166 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04964432 0,07746401 ! intestinal absorption GO:0050892 19 12 0,000 0,04964432 0,07741149 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04964432 0,07735904 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04964432 0,07730667 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,04964432 0,07725436 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04964432 0,07720213 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,04964432 0,07714996 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04964432 0,07709787 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04964432 0,07704585 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04964432 0,0769939 ! response to cold GO:0009409 14 12 0,000 0,04964432 0,07694201 ! transcription initiation GO:0006352 118 85 1,000 0,05037325 0,07801918 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,05037325 0,07796667 ! regulation of membrane potential GO:0042391 128 85 1,000 0,05037325 0,07791424 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,05037325 0,07786188 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,05143466 0,0794491 ! female pregnancy GO:0007565 130 87 1,000 0,05250411 0,08104661 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,05358152 0,08265425 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,05366987 0,08273506 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,05366987 0,08267964 ! cGMP metabolic process GO:0046068 16 13 0,000 0,05366987 0,0826243 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,05366987 0,08256903 ! water transport GO:0006833 17 13 0,000 0,05366987 0,08251384 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,05366987 0,08245872 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,05366987 0,08240368 ! lipid localization GO:0010876 24 13 0,000 0,05366987 0,0823487 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,05366987 0,0822938 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,05366987 0,08223898 ! organelle fusion GO:0048284 28 13 0,000 0,05366987 0,08218423 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,05366987 0,08212955 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,05366987 0,08207494 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,05366987 0,0820204 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,05366987 0,08196594 ! response to hexose stimulus GO:0009746 19 13 0,000 0,05366987 0,08191155 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,05366987 0,08185723 ! glutamate metabolic process GO:0006536 18 13 0,000 0,05366987 0,08180299 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,05366987 0,08174881 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,05366987 0,08169471 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,05366987 0,08164068 ! NAD metabolic process GO:0019674 21 13 0,000 0,05366987 0,08158672 ! bone mineralization GO:0030282 15 13 0,000 0,05366987 0,08153283 ! regulation of exocytosis GO:0017157 17 13 0,000 0,05366987 0,08147901 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,05366987 0,08142527 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,05366987 0,08137159 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,05366987 0,08131799 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,05366987 0,08126445 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,05366987 0,08121099 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,05366987 0,0811576 ! genitalia development GO:0048806 15 13 0,000 0,05366987 0,08110428 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,05366987 0,08105102 ! tissue regeneration GO:0042246 21 13 0,000 0,05366987 0,08099784 ! cofactor transport GO:0051181 19 13 0,000 0,05366987 0,08094473 ! NADP metabolic process GO:0006739 18 13 0,000 0,05366987 0,08089168 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,05366987 0,08083871 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,05366987 0,0807858 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05366987 0,08073297 ! gas transport GO:0015669 18 13 0,000 0,05366987 0,0806802 ! regulation of RNA stability GO:0043487 28 13 0,000 0,05366987 0,0806275 ! heme biosynthetic process GO:0006783 20 13 0,000 0,05366987 0,08057487 ! regulation of axon extension GO:0030516 23 13 0,000 0,05366987 0,08052231 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,05366987 0,08046982 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,05366987 0,0804174 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,05366987 0,08036504 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,05366987 0,08031276 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,05366987 0,08026054 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,0546668 0,08169827 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,05575987 0,08327773 ! response to virus GO:0009615 122 91 1,000 0,05686065 0,08486664 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,0576786 0,08603163 ! superoxide anion generation GO:0042554 18 14 0,000 0,0576786 0,08597588 ! neuron maturation GO:0042551 21 14 0,000 0,0576786 0,08592019 ! regulation of S phase GO:0033261 18 14 0,000 0,0576786 0,08586458 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,0576786 0,08580904 ! myotube differentiation GO:0014902 21 14 0,000 0,0576786 0,08575357 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,0576786 0,08569818 ! inositol metabolic process GO:0006020 20 14 0,000 0,0576786 0,08564285 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,0576786 0,0855876 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,0576786 0,08553242 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,0576786 0,0854773 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,0576786 0,08542226 ! gene silencing by RNA GO:0031047 20 14 0,000 0,0576786 0,08536729 ! response to cAMP GO:0051591 19 14 0,000 0,0576786 0,0853124 ! limbic system development GO:0021761 25 14 0,000 0,0576786 0,08525757 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,0576786 0,08520281 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,0576786 0,08514812 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,0576786 0,08509351 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,0576786 0,08503896 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,0576786 0,08498448 ! glycine metabolic process GO:0006544 22 14 0,000 0,0576786 0,08493007 ! pituitary gland development GO:0021983 23 14 0,000 0,0576786 0,08487574 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,0576786 0,08482147 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,0576786 0,08476727 ! regulation of heart rate GO:0002027 23 14 0,000 0,0576786 0,08471314 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,0576786 0,08465908 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,0576786 0,08460509 ! embryo implantation GO:0007566 27 14 0,000 0,0576786 0,08455116 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,0576786 0,08449731 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,0576786 0,08444352 ! axon cargo transport GO:0008088 27 14 0,000 0,0576786 0,08438981 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,0576786 0,08433616 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,0576786 0,08428258 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,0576786 0,08422906 ! mRNA splice site selection GO:0006376 26 14 0,000 0,0576786 0,08417562 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,0576786 0,08412224 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,0576786 0,08406893 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,0576786 0,08401569 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,0576786 0,08396252 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,0576786 0,08390941 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,0576786 0,08385637 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,0576786 0,0838034 ! muscle maintenance GO:0046716 19 14 0,000 0,0576786 0,08375049 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,0576786 0,08369765 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,0576786 0,08364488 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,0576786 0,08359217 ! cell killing GO:0001906 20 14 0,000 0,0576786 0,08353953 ! cilium assembly GO:0042384 20 14 0,000 0,0576786 0,08348696 ! peptide hormone secretion GO:0030072 23 14 0,000 0,0576786 0,08343445 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,05796904 0,08380189 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,05908498 0,08536147 ! response to oxidative stress GO:0006979 141 94 1,000 0,06020838 0,08692987 ! angiogenesis GO:0001525 149 95 1,000 0,06133916 0,08850694 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,06167057 0,08892935 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,06167057 0,08887363 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,06167057 0,08881798 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,06167057 0,0887624 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,06167057 0,08870689 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,06167057 0,08865145 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,06167057 0,08859607 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,06167057 0,08854077 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,06167057 0,08848554 ! bile acid metabolic process GO:0008206 22 15 0,000 0,06167057 0,08843037 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,06167057 0,08837527 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,06167057 0,08832025 ! adult walking behavior GO:0007628 25 15 0,000 0,06167057 0,08826529 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,06167057 0,08821039 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,06167057 0,08815557 ! centrosome cycle GO:0007098 16 15 0,000 0,06167057 0,08810082 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,06167057 0,08804613 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,06167057 0,08799151 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,06167057 0,08793696 ! cerebral cortex development GO:0021987 29 15 0,000 0,06167057 0,08788247 ! response to osmotic stress GO:0006970 22 15 0,000 0,06167057 0,08782806 ! vesicle coating GO:0006901 25 15 0,000 0,06167057 0,08777371 ! DNA integration GO:0015074 22 15 0,000 0,06167057 0,08771943 ! peptide secretion GO:0002790 27 15 0,000 0,06167057 0,08766521 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,06167057 0,08761106 ! regulation of vasodilation GO:0042312 24 15 0,000 0,06167057 0,08755698 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,06167057 0,08750297 ! neuron recognition GO:0008038 22 15 0,000 0,06167057 0,08744902 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,06167057 0,08739514 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,06167057 0,08734133 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,06167057 0,08728758 ! biomineral formation GO:0031214 18 15 0,000 0,06167057 0,0872339 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,06167057 0,08718028 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,06167057 0,08712673 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,06167057 0,08707324 ! organic cation transport GO:0015695 19 15 0,000 0,06167057 0,08701982 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,06167057 0,08696647 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,06167057 0,08691318 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! peptide hormone processing GO:0016486 19 15 0,000 0,06167057 0,08685996 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,06167057 0,0868068 ! in utero embryonic development GO:0001701 147 96 1,000 0,06247723 0,08788846 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,06247723 0,08783474 ! protein secretion GO:0009306 27 16 0,000 0,06564586 0,09223304 ! hormone secretion GO:0046879 25 16 0,000 0,06564586 0,09217673 ! bone remodeling GO:0046849 24 16 0,000 0,06564586 0,09212049 ! endothelial cell migration GO:0043542 22 16 0,000 0,06564586 0,09206432 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,06564586 0,09200821 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06564586 0,09195218 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,06564586 0,09189621 ! glial cell development GO:0021782 24 16 0,000 0,06564586 0,09184032 ! patterning of blood vessels GO:0001569 24 16 0,000 0,06564586 0,09178449 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,06564586 0,09172872 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,06564586 0,09167303 ! protein polyubiquitination GO:0000209 26 16 0,000 0,06564586 0,0916174 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,06564586 0,09156184 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,06564586 0,09150635 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,06564586 0,09145093 ! fructose metabolic process GO:0006000 20 16 0,000 0,06564586 0,09139557 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,06564586 0,09134028 ! protein export from nucleus GO:0006611 24 16 0,000 0,06564586 0,09128505 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,06564586 0,0912299 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,06564586 0,09117481 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,06564586 0,09111978 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,06564586 0,09106482 ! diencephalon development GO:0021536 25 16 0,000 0,06564586 0,09100993 ! neural crest cell migration GO:0001755 24 16 0,000 0,06564586 0,09095511 ! G1 phase GO:0051318 27 16 0,000 0,06564586 0,09090035 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,06564586 0,09084566 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,06564586 0,09079103 ! steroid catabolic process GO:0006706 22 16 0,000 0,06564586 0,09073647 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,06564586 0,09068197 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,06564586 0,09062754 ! sperm-egg recognition GO:0035036 16 16 0,000 0,06564586 0,09057317 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,06564586 0,09051887 ! nerve development GO:0021675 18 16 0,000 0,06564586 0,09046464 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,06564586 0,09041047 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,06564586 0,09035636 ! negative regulation of translation GO:0017148 22 16 0,000 0,06564586 0,09030232 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,06960453 0,09569063 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,06960453 0,09563347 ! negative regulation of defense response GO:0031348 19 17 0,000 0,06960453 0,09557638 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,06960453 0,09551935 ! glycerol metabolic process GO:0006071 20 17 0,000 0,06960453 0,09546239 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,06960453 0,0954055 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,06960453 0,09534868 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,06960453 0,09529192 ! signal complex assembly GO:0007172 29 17 0,000 0,06960453 0,09523524 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,06960453 0,09517861 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,06960453 0,09512206 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,06960453 0,09506558 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,06960453 0,09500916 ! memory GO:0007613 25 17 0,000 0,06960453 0,09495281 ! keratinization GO:0031424 17 17 0,000 0,06960453 0,09489652 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,06960453 0,0948403 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,06960453 0,09478415 ! retinoid metabolic process GO:0001523 22 17 0,000 0,06960453 0,09472807 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,06960453 0,09467205 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,06960453 0,09461609 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,06960453 0,09456021 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,06960453 0,09450439 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,06960453 0,09444863 ! membrane budding GO:0006900 29 17 0,000 0,06960453 0,09439294 ! heme metabolic process GO:0042168 27 17 0,000 0,06960453 0,09433732 ! actin filament bundle formation GO:0051017 26 17 0,000 0,06960453 0,09428176 ! neuromuscular junction development GO:0007528 23 17 0,000 0,06960453 0,09422627 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,06960453 0,09417084 ! body fluid secretion GO:0007589 27 17 0,000 0,06960453 0,09411548 ! stem cell differentiation GO:0048863 36 17 0,000 0,06960453 0,09406018 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,06960453 0,09400495 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,06960453 0,09394978 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,06960453 0,09389468 ! sensory perception of pain GO:0019233 23 17 0,000 0,06960453 0,09383964 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,06960453 0,09378467 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,06960453 0,09372976 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,06960453 0,09367492 ! synaptogenesis GO:0007416 24 17 0,000 0,06960453 0,09362013 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,06960453 0,09356542 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,06960453 0,09351077 ! cell-cell junction organization GO:0045216 25 17 0,000 0,06960453 0,09345618 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,06960453 0,09340165 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,06960453 0,09334719 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,06960453 0,09329279 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,06960453 0,09323846 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,06960453 0,09318419 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,07354666 0,09840449 ! positive regulation of translation GO:0045727 28 18 0,000 0,07354666 0,09834728 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,07354666 0,09829014 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,07354666 0,09823306 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,07354666 0,09817604 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,07354666 0,0981191 ! cAMP metabolic process GO:0046058 33 18 0,000 0,07354666 0,09806222 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,07354666 0,0980054 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,07354666 0,09794865 ! axis specification GO:0009798 26 18 0,000 0,07354666 0,09789197 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,07354666 0,09783535 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,07354666 0,0977788 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,07354666 0,09772231 ! glutamine metabolic process GO:0006541 23 18 0,000 0,07354666 0,09766589 ! response to retinoic acid GO:0032526 25 18 0,000 0,07354666 0,09760954 ! central nervous system neuron development GO:0021954 30 18 0,000 0,07354666 0,09755324 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,07354666 0,09749702 ! fucose metabolic process GO:0006004 26 18 0,000 0,07354666 0,09744086 ! response to fungus GO:0009620 19 18 0,000 0,07354666 0,09738476 ! peptide cross-linking GO:0018149 31 18 0,000 0,07354666 0,09732873 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,07354666 0,09727276 ! heart process GO:0003015 27 18 0,000 0,07354666 0,09721685 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,07354666 0,09716101 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,07354666 0,09710524 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,07354666 0,09704953 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,07354666 0,09699388 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,07354666 0,09693829 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,07354666 0,09688277 ! vitamin transport GO:0051180 24 18 0,000 0,07354666 0,09682732 ! hormone transport GO:0009914 27 18 0,000 0,07354666 0,09677192 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,07354666 0,09671659 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,07354666 0,09666133 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,07354666 0,09660612 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,07354666 0,09655098 ! cell-cell recognition GO:0009988 20 18 0,000 0,07354666 0,09649591 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,07354666 0,09644089 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,07354666 0,09638594 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,07354666 0,09633105 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,07354666 0,09627622 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,07747231 0,10135741 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,07747231 0,10129978 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,07747231 0,10124223 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,07747231 0,10118474 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,07747231 0,10112731 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,07747231 0,10106995 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,07747231 0,10101265 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,07747231 0,10095542 ! sensory perception of taste GO:0050909 23 19 0,000 0,07747231 0,10089826 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,07747231 0,10084115 ! smooth muscle contraction GO:0006939 36 19 0,000 0,07747231 0,10078412 ! peroxisome organization GO:0007031 29 19 0,000 0,07747231 0,10072714 ! digestive system process GO:0022600 30 19 0,000 0,07747231 0,10067024 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,07747231 0,10061339 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,07747231 0,10055661 ! response to vitamin A GO:0033189 26 19 0,000 0,07747231 0,1004999 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,07747231 0,10044325 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,07747231 0,10038666 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,07747231 0,10033013 ! plasma membrane fusion GO:0045026 23 19 0,000 0,07747231 0,10027367 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,07747231 0,10021728 ! cytolysis GO:0019835 20 19 0,000 0,07747231 0,10016094 ! vasodilation GO:0042311 33 19 0,000 0,07747231 0,10010467 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,07747231 0,10004847 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,07747231 0,09999232 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,07747231 0,09993624 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,07747231 0,09988022 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,07747231 0,09982427 ! sarcomere organization GO:0045214 23 19 0,000 0,07747231 0,09976838 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,07747231 0,09971255 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,07747231 0,09965678 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,07747231 0,09960107 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,07747231 0,09954543 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,07747231 0,09948985 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,07747231 0,09943433 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,07747231 0,09937887 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,07747231 0,09932348 ! protein stabilization GO:0050821 26 19 0,000 0,07747231 0,09926814 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,08138155 0,10421914 ! iron ion transport GO:0006826 37 20 0,000 0,08138155 0,10416114 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,08138155 0,10410321 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,08138155 0,10404534 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,08138155 0,10398754 ! response to vitamin GO:0033273 29 20 0,000 0,08138155 0,1039298 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,08138155 0,10387213 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,08138155 0,10381451 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,08138155 0,10375697 ! spinal cord development GO:0021510 31 20 0,000 0,08138155 0,10369948 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,08138155 0,10364207 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,08138155 0,10358471 ! chromosome condensation GO:0030261 31 20 0,000 0,08138155 0,10352742 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,08138155 0,10347019 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,08138155 0,10341302 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,08138155 0,10335592 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,08138155 0,10329888 ! pallium development GO:0021543 38 20 0,000 0,08138155 0,1032419 ! DNA modification GO:0006304 28 20 0,000 0,08138155 0,10318499 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,08138155 0,10312814 ! collagen catabolic process GO:0030574 25 20 0,000 0,08138155 0,10307135 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,08138155 0,10301462 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,08138155 0,10295796 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,08138155 0,10290136 ! alditol metabolic process GO:0019400 24 20 0,000 0,08138155 0,10284482 ! actin filament-based movement GO:0030048 34 20 0,000 0,08138155 0,10278834 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,08527445 0,10764612 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,08527445 0,10758707 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,08527445 0,10752809 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,08527445 0,10746917 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,08527445 0,10741031 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,08527445 0,10735152 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,08527445 0,1072928 ! vesicle docking GO:0048278 27 21 0,000 0,08527445 0,10723413 ! phototransduction GO:0007602 25 21 0,000 0,08527445 0,10717554 ! dendrite development GO:0016358 35 21 0,000 0,08527445 0,107117 ! visual behavior GO:0007632 39 21 0,000 0,08527445 0,10705853 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,08527445 0,10700013 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,08527445 0,10694178 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,08527445 0,10688351 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,08527445 0,10682529 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,08527445 0,10676714 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,08527445 0,10670905 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,08527445 0,10665102 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,08527445 0,10659306 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,08527445 0,10653516 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,08527445 0,10647732 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,08527445 0,10641955 ! fatty acid transport GO:0015908 30 21 0,000 0,08527445 0,10636184 ! immunoglobulin production GO:0002377 33 21 0,000 0,08527445 0,10630419 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,08527445 0,1062466 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,08527445 0,10618908 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,08527445 0,10613162 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,08527445 0,10607422 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,08527445 0,10601688 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,08527445 0,10595961 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,08527445 0,10590239 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,08527445 0,10584524 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,08527445 0,10578815 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,08527445 0,10573112 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,08527445 0,10567416 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,08915107 0,11041867 ! viral genome replication GO:0019079 29 22 0,000 0,08915107 0,11035924 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,08915107 0,11029987 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,08915107 0,11024057 ! leukocyte adhesion GO:0007159 38 22 0,000 0,08915107 0,11018133 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,08915107 0,11012216 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,08915107 0,11006305 ! vasculogenesis GO:0001570 33 22 0,000 0,08915107 0,110004 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,08915107 0,10994502 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,08915107 0,1098861 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,08915107 0,10982724 ! lysosome organization GO:0007040 37 22 0,000 0,08915107 0,10976845 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,08915107 0,10970972 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,08915107 0,10965105 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,08915107 0,10959244 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,08915107 0,1095339 ! membrane depolarization GO:0051899 35 22 0,000 0,08915107 0,10947542 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,08915107 0,109417 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,08915107 0,10935865 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,08915107 0,10930035 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,08915107 0,10924212 ! blastocyst development GO:0001824 37 22 0,000 0,08915107 0,10918395 ! neural tube closure GO:0001843 33 22 0,000 0,08915107 0,10912584 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,08915107 0,1090678 ! neuron fate commitment GO:0048663 32 23 0,000 0,09301148 0,11373015 ! myelination GO:0042552 35 23 0,000 0,09301148 0,11366972 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,09301148 0,11360935 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,09301148 0,11354905 ! vesicle targeting GO:0006903 32 23 0,000 0,09301148 0,11348881 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,09301148 0,11342864 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,09301148 0,11336853 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,09301148 0,11330848 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,09301148 0,1132485 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,09301148 0,11318858 ! cell fate determination GO:0001709 45 23 0,000 0,09301148 0,11312872 ! pentose metabolic process GO:0019321 31 23 0,000 0,09301148 0,11306893 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,09301148 0,1130092 ! spermatid development GO:0007286 33 23 0,000 0,09301148 0,11294953 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,09301148 0,11288993 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,09301148 0,11283039 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,09301148 0,11277091 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,09301148 0,11271149 ! telomere organization GO:0032200 32 23 0,000 0,09301148 0,11265214 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,09301148 0,11259285 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,09301148 0,11253362 ! regulation of amine transport GO:0051952 38 23 0,000 0,09301148 0,11247445 ! liver development GO:0001889 40 23 0,000 0,09301148 0,11241535 ! initiation of viral infection GO:0019059 42 24 0,000 0,09685576 0,11700013 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,09685576 0,11693871 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,09685576 0,11687736 ! superoxide metabolic process GO:0006801 32 24 0,000 0,09685576 0,11681607 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,09685576 0,11675484 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,09685576 0,11669368 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,09685576 0,11663259 ! sperm motility GO:0030317 27 24 0,000 0,09685576 0,11657155 ! vacuole organization GO:0007033 39 24 0,000 0,09685576 0,11651059 ! receptor metabolic process GO:0043112 37 24 0,000 0,09685576 0,11644968 ! neural crest cell development GO:0014032 39 24 0,000 0,09685576 0,11638884 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 0,000 0,09685576 0,11632806 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,09685576 0,11626735 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,09685576 0,1162067 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,09685576 0,11614611 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,09685576 0,11608559 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,09685576 0,11602512 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,09685576 0,11596473 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,10068395 0,12048548 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,10068395 0,12042283 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,10068395 0,12036024 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,10068395 0,12029771 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,10068395 0,12023525 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,10068395 0,12017286 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,10068395 0,12011053 ! peptide transport GO:0015833 43 25 0,000 0,10068395 0,12004826 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,10068395 0,11998606 ! phospholipid transport GO:0015914 35 25 0,000 0,10068395 0,11992392 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,10068395 0,11986185 ! detection of light stimulus GO:0009583 30 25 0,000 0,10068395 0,11979984 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,10068395 0,1197379 GO:0045840|positive regulation of mitosis, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,10068395 0,11967602 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,10449614 0,12414315 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,10449614 0,12407905 ! translational initiation GO:0006413 43 26 0,000 0,10449614 0,12401503 ! circadian rhythm GO:0007623 42 26 0,000 0,10449614 0,12395107 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,10449614 0,12388718 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,10449614 0,12382335 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,10449614 0,12375959 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,10449614 0,1236959 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,10449614 0,12363227 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,10449614 0,1235687 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,10449614 0,12350521 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,10449614 0,12344177 ! regulation of coagulation GO:0050818 39 26 0,000 0,10449614 0,1233784 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,10829239 0,12779502 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,10829239 0,12772949 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,10829239 0,12766402 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,10829239 0,12759862 ! membrane docking GO:0022406 39 27 0,000 0,10829239 0,12753328 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,10829239 0,12746801 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,10829239 0,12740281 ! acute-phase response GO:0006953 42 27 0,000 0,10829239 0,12733768 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,10829239 0,12727261 ! myofibril assembly GO:0030239 36 27 0,000 0,10829239 0,12720761 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,10829239 0,12714267 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,10829239 0,1270778 ! natural killer cell activation GO:0030101 35 27 0,000 0,10829239 0,127013 ! lipid oxidation GO:0034440 38 27 0,000 0,10829239 0,12694827 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,10829239 0,1268836 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,10829239 0,12681899 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,10829239 0,12675445 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,10829239 0,12668998 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,10829239 0,12662557 ! gene silencing GO:0016458 41 27 0,000 0,10829239 0,12656123 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,11207276 0,13091282 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,11207276 0,13084637 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,11207276 0,13077998 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,11207276 0,13071367 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,11207276 0,13064741 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,11207276 0,13058123 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,11207276 0,13051511 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,11207276 0,13044906 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,11207276 0,13038308 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,11207276 0,13031716 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,11207276 0,13025131 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,11207276 0,13018553 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,11207276 0,13011981 ! ensheathment of neurons GO:0007272 43 28 0,000 0,11207276 0,13005416 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,11207276 0,12998858 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,11207276 0,12992306 ! neural tube formation GO:0001841 41 28 0,000 0,11207276 0,12985761 ! placenta development GO:0001890 37 28 0,000 0,11207276 0,12979222 ! regulation of innate immune response GO:0045088 38 29 0,000 0,11583732 0,13408447 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,11583732 0,13401702 ! protein targeting to membrane GO:0006612 53 29 0,000 0,11583732 0,13394964 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,11583732 0,13388233 ! mismatch repair GO:0006298 34 29 0,000 0,11583732 0,13381509 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,11583732 0,13374791 ! muscle cell development GO:0055001 38 29 0,000 0,11583732 0,1336808 ! telencephalon development GO:0021537 52 29 0,000 0,11583732 0,13361376 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,11583732 0,13354678 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,11583732 0,13347988 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,11958613 0,13773065 ! organic anion transport GO:0015711 51 30 0,000 0,11958613 0,13766171 ! cholesterol transport GO:0030301 46 30 0,000 0,11958613 0,13759285 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,11958613 0,13752405 ! spindle organization GO:0007051 37 30 0,000 0,11958613 0,13745533 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,11958613 0,13738667 ! ceramide metabolic process GO:0006672 43 30 0,000 0,11958613 0,13731808 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,11958613 0,13724955 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,11958613 0,1371811 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,11958613 0,13711271 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,11958613 0,1370444 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,11958613 0,13697615 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,11958613 0,13690797 ! negative regulation of secretion GO:0051048 49 31 0,000 0,12331927 0,1411116 ! mammary gland development GO:0030879 57 31 0,000 0,12331927 0,14104143 ! glial cell differentiation GO:0010001 55 31 0,000 0,12331927 0,14097133 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,12331927 0,1409013 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,12331927 0,14083134 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,12331927 0,14076144 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,12331927 0,14069162 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,12331927 0,14062187 ! cell fate specification GO:0001708 37 31 0,000 0,12331927 0,14055219 ! RNA modification GO:0009451 40 31 0,000 0,12331927 0,14048257 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,12703678 0,14464584 ! meiosis I GO:0007127 52 32 0,000 0,12703678 0,14457427 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,12703678 0,14450277 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,12703678 0,14443134 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,12703678 0,14435998 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 0,000 0,12703678 0,14428869 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,12703678 0,14421747 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,12703678 0,14414632 ! cytokine production GO:0001816 44 32 0,000 0,12703678 0,14407525 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,12703678 0,14400424 ! vesicle localization GO:0051648 47 32 0,000 0,12703678 0,1439333 ! RNA export from nucleus GO:0006405 44 33 0,000 0,13073875 0,14805471 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,13073875 0,14798185 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,13073875 0,14790906 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,13073875 0,14783634 ! sister chromatid segregation GO:0000819 46 33 0,000 0,13073875 0,14776369 ! actomyosin structure organization GO:0031032 43 33 0,000 0,13073875 0,14769112 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,13073875 0,14761861 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,13073875 0,14754618 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,13073875 0,14747382 ! lipid homeostasis GO:0055088 55 33 0,000 0,13073875 0,14740153 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,13073875 0,14732931 ! regulation of proteolysis GO:0030162 50 33 0,000 0,13073875 0,14725716 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,13073875 0,14718508 ! cytokinesis GO:0000910 52 33 0,000 0,13073875 0,14711307 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,13073875 0,14704113 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,13442522 0,1511134 ! mRNA catabolic process GO:0006402 48 34 0,000 0,13442522 0,15103958 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,13442522 0,15096583 ! feeding behavior GO:0007631 45 34 0,000 0,13442522 0,15089215 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,13442522 0,15081854 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,13442522 0,15074501 ! neuron migration GO:0001764 46 34 0,000 0,13442522 0,15067155 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,13442522 0,15059815 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,13442522 0,15052484 ! polyol metabolic process GO:0019751 44 34 0,000 0,13442522 0,15045159 ! aerobic respiration GO:0009060 47 34 0,000 0,13442522 0,15037841 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,13442522 0,1503053 ! embryonic organ development GO:0048568 45 34 0,000 0,13442522 0,15023227 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,13809628 0,15426005 ! Notch signaling pathway GO:0007219 56 35 0,000 0,13809628 0,15418516 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,13809628 0,15411035 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,13809628 0,15403561 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,13809628 0,15396095 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,13809628 0,15388635 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,13809628 0,15381183 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,13809628 0,15373738 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,13809628 0,15366301 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,13809628 0,1535887 ! protein homooligomerization GO:0051260 52 35 0,000 0,13809628 0,15351447 ! negative regulation of binding GO:0051100 58 36 0,000 0,14175197 0,15750219 ! organic ether metabolic process GO:0018904 46 36 0,000 0,14175197 0,15742614 ! tissue remodeling GO:0048771 62 36 0,000 0,14175197 0,15735016 ! neural tube development GO:0021915 50 36 0,000 0,14175197 0,15727425 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,14175197 0,15719842 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,14175197 0,15712266 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,14175197 0,15704698 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,14539236 0,16100262 ! learning GO:0007612 67 37 0,000 0,14539236 0,16092514 ! ion transmembrane transport GO:0034220 56 37 0,000 0,14539236 0,16084773 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,14539236 0,1607704 ! regulation of protein secretion GO:0050708 51 37 0,000 0,14539236 0,16069315 ! amino acid activation GO:0043038 52 37 0,000 0,14539236 0,16061596 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,14539236 0,16053886 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,14901753 0,16446272 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,14901753 0,16438384 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,14901753 0,16430504 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,14901753 0,16422631 ! phagocytosis GO:0006909 60 38 0,000 0,14901753 0,16414766 ! maintenance of location in cell GO:0051651 69 38 0,000 0,14901753 0,16406908 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,15262752 0,1679633 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,15262752 0,16788297 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,15262752 0,16780272 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,15262752 0,16772255 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,15262752 0,16764245 ! chromatin remodeling GO:0006338 68 39 0,000 0,15262752 0,16756243 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,15262752 0,16748249 ! JNK cascade GO:0007254 54 39 0,000 0,15262752 0,16740262 ! synapse organization GO:0050808 55 39 0,000 0,15262752 0,16732283 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,1562224 0,17118224 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,1562224 0,17110073 ! regulation of tube size GO:0035150 60 40 0,000 0,1562224 0,17101929 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,1562224 0,17093793 ! inner ear development GO:0048839 57 40 0,000 0,1562224 0,17085665 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,1562224 0,17077544 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,1562224 0,17069431 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,1562224 0,17061326 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,15980224 0,17444004 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,15980224 0,17435729 ! glucose transport GO:0015758 52 41 0,000 0,15980224 0,17427461 ! endosome transport GO:0016197 71 41 0,000 0,15980224 0,17419202 ! striated muscle contraction GO:0006941 62 41 0,000 0,15980224 0,1741095 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,15980224 0,17402706 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,15980224 0,1739447 ! biopolymer methylation GO:0043414 62 41 0,000 0,15980224 0,17386242 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,15980224 0,17378022 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,1633671 0,17757293 ! hexose transport GO:0008645 54 42 0,000 0,1633671 0,17748905 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,1633671 0,17740525 ! excretion GO:0007588 63 42 0,000 0,1633671 0,17732153 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,1633671 0,17723789 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,1633671 0,17715433 ! regulation of cell shape GO:0008360 78 42 0,000 0,1633671 0,17707084 ! tRNA processing GO:0008033 49 43 0,000 0,16691703 0,18083333 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,16691703 0,1807482 ! methylation GO:0032259 64 43 0,000 0,16691703 0,18066314 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,1704521 0,18440256 ! glycolysis GO:0006096 53 44 0,000 0,1704521 0,18431586 ! regulation of action potential GO:0001508 71 44 0,000 0,1704521 0,18422925 ! regulation of ion transport GO:0043269 57 44 0,000 0,1704521 0,18414271 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,1704521 0,18405626 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,1704521 0,18396989 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,1704521 0,1838836 ! RNA catabolic process GO:0006401 64 45 0,000 0,17397238 0,18759328 ! regulation of translational initiation GO:0006446 64 45 0,000 0,17397238 0,18750537 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,17397238 0,18741755 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,17397238 0,18732981 ! cell recognition GO:0008037 58 45 0,000 0,17397238 0,18724215 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,17747791 0,19092573 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,17747791 0,19083647 ! cell redox homeostasis GO:0045454 63 46 0,000 0,17747791 0,19074729 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,17747791 0,1906582 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,17747791 0,19056919 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,18096877 0,19422687 ! viral infectious cycle GO:0019058 71 47 0,000 0,18096877 0,19413628 ! endocrine system development GO:0035270 83 47 0,000 0,18096877 0,19404577 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,18096877 0,19395535 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,18096877 0,19386501 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,18096877 0,19377476 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,18096877 0,19368459 ! chloride transport GO:0006821 67 48 0,000 0,18444502 0,19731328 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,18444502 0,19722154 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,18444502 0,1971299 ! regulation of endocytosis GO:0030100 63 48 0,000 0,18444502 0,19703834 ! nuclear export GO:0051168 69 48 0,000 0,18444502 0,19694686 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,18444502 0,19685547 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,18444502 0,19676417 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,18790671 0,20036413 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,18790671 0,20027128 ! sensory perception of smell GO:0007608 61 49 0,000 0,18790671 0,20017852 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,18790671 0,20008584 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,18790671 0,19999326 ! RNA elongation GO:0006354 62 49 0,000 0,18790671 0,19990075 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,18790671 0,19980833 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,18790671 0,199716 ! maintenance of location GO:0051235 84 49 0,000 0,18790671 0,19962375 ! regulation of actin filament length GO:0030832 72 50 0,000 0,1913539 0,20319204 ! membrane fusion GO:0006944 80 50 0,000 0,1913539 0,20309828 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,1913539 0,2030046 ! proton transport GO:0015992 75 50 0,000 0,1913539 0,202911 ! hydrogen transport GO:0006818 77 51 0,000 0,19478666 0,2064559 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,19478666 0,2063608 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,19478666 0,2062658 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,19478666 0,20617087 ! transition metal ion transport GO:0000041 74 52 0,000 0,19820504 0,20969254 ! regulation of cellular component size GO:0032535 74 52 0,000 0,19820504 0,20959613 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,19820504 0,20949981 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,19820504 0,20940357 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,2016091 0,21290217 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,2016091 0,21280446 ! single fertilization GO:0007338 59 53 0,000 0,2016091 0,21270685 ! amino acid transport GO:0006865 84 54 0,000 0,2049989 0,21618408 ! regulation of mitosis GO:0007088 84 54 0,000 0,2049989 0,21608501 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,2049989 0,21598602 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,2049989 0,21588713 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,2049989 0,21578832 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,2049989 0,21568961 ! exocytosis GO:0006887 74 55 0,000 0,20837451 0,219141 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,20837451 0,21904085 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,20837451 0,21894078 ! carbohydrate transport GO:0008643 74 57 0,000 0,21508336 0,22588664 ! chromosome segregation GO:0007059 83 57 0,000 0,21508336 0,22578354 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,21508336 0,22568054 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,21508336 0,22557763 ! camera-type eye development GO:0043010 88 57 0,000 0,21508336 0,22547481 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,21841673 0,22886491 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,22173612 0,23223729 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,22504161 0,23559204 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,22504161 0,23548485 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,22504161 0,23537777 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,22504161 0,23527078 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,22504161 0,23516388 ! fertilization GO:0009566 68 60 0,000 0,22504161 0,23505709 ! meiosis GO:0007126 96 61 0,000 0,22833325 0,23838696 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,22833325 0,2382788 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,22833325 0,23817074 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,22833325 0,23806277 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,22833325 0,2379549 ! amine catabolic process GO:0009310 90 62 0,000 0,23161109 0,24126156 ! neurotransmitter transport GO:0006836 81 62 0,000 0,23161109 0,24115234 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,23161109 0,24104322 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,23161109 0,2409342 ! meiotic cell cycle GO:0051321 97 62 0,000 0,23161109 0,24082528 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,2348752 0,24410889 ! regulation of lipase activity GO:0060191 109 63 0,000 0,2348752 0,24399863 ! appendage morphogenesis GO:0035107 93 64 0,000 0,23812563 0,24726364 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,23812563 0,24715206 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,23812563 0,24704058 ! hexose catabolic process GO:0019320 82 64 0,000 0,23812563 0,2469292 ! appendage development GO:0048736 94 65 0,000 0,24136244 0,25017288 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,24136244 0,25006019 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,24136244 0,2499476 ! defense response to bacterium GO:0042742 73 65 0,000 0,24136244 0,24983511 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,24136244 0,24972272 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,24458568 0,25294382 ! antigen processing and presentation GO:0019882 96 66 0,000 0,24458568 0,25283014 ! axon guidance GO:0007411 99 66 0,000 0,24458568 0,25271656 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,24458568 0,25260308 ! regulation of immune effector process GO:0002697 101 66 0,000 0,24458568 0,25248971 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,24779541 0,2556884 ! learning or memory GO:0007611 123 68 0,000 0,25099169 0,25887035 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,25099169 0,25875432 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,25099169 0,25863839 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,25099169 0,25852256 ! inorganic anion transport GO:0015698 93 68 0,000 0,25099169 0,25840684 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,25417456 0,26156666 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,25417456 0,26144968 ! amine transport GO:0015837 101 70 0,000 0,2573441 0,26459161 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,2573441 0,26447338 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,26050034 0,26759749 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,26050034 0,26747803 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,26050034 0,26735867 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,26050034 0,26723942 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,26364335 0,27034316 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,26364335 0,27022269 ! regulation of blood pressure GO:0008217 107 73 0,000 0,26677319 0,27330883 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,26677319 0,27318714 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,26988989 0,27625579 ! digestion GO:0007586 97 74 0,000 0,26988989 0,2761329 ! blood coagulation GO:0007596 116 75 0,000 0,27299353 0,27918414 GO:0050817|coagulation, ! regulation of ligase activity GO:0051340 114 75 0,000 0,27299353 0,27906006 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,27299353 0,27893609 ! tRNA metabolic process GO:0006399 95 76 0,000 0,27608416 0,28196872 ! response to unfolded protein GO:0006986 99 76 0,000 0,27608416 0,28184357 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,27916182 0,284859 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,27916182 0,28473267 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,27916182 0,28460646 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,27916182 0,28448036 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,28222657 0,28747614 ! cellular respiration GO:0045333 107 79 0,000 0,28527847 0,29045617 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,28527847 0,29032765 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,28527847 0,29019924 ! chromatin assembly GO:0031497 102 80 0,000 0,28831757 0,2931611 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,28831757 0,29303155 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,28831757 0,29290212 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,28831757 0,2927728 ! forebrain development GO:0030900 131 80 0,000 0,28831757 0,2926436 ! hemostasis GO:0007599 125 81 0,000 0,29134391 0,29558491 ! mRNA transport GO:0051028 121 81 0,000 0,29134391 0,29545459 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,29134391 0,29532437 ! vitamin metabolic process GO:0006766 103 81 0,000 0,29134391 0,29519427 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,30034699 0,30418233 ! sterol metabolic process GO:0016125 120 84 0,000 0,30034699 0,30404845 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,30332287 0,30692591 ! rRNA metabolic process GO:0016072 107 85 0,000 0,30332287 0,30679094 GO:0006364|rRNA processing, ! nucleosome organization GO:0034728 114 87 0,000 0,30923721 0,31263542 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,30923721 0,31249806 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,30923721 0,31236082 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,31217578 0,31519065 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,31217578 0,31505235 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,31217578 0,31491417 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,31510202 0,31772672 ! regulation of T cell activation GO:0050863 128 89 0,000 0,31510202 0,31758749 ! hormone metabolic process GO:0042445 121 90 0,000 0,31801598 0,32038404 ! RNA localization GO:0006403 135 91 0,000 0,32091771 0,32316582 ! ATP metabolic process GO:0046034 137 91 0,000 0,32091771 0,32302439 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,32380725 0,32579032 ! DNA recombination GO:0006310 146 92 0,000 0,32380725 0,32564787 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,32668467 0,32839805 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,32668467 0,32825458 ! electron transport chain GO:0022900 123 94 0,000 0,32955 0,33098909 ! carboxylic acid transport GO:0046942 147 95 0,000 0,33240331 0,33370913 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,33524464 0,33641478 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,33807403 0,3391061 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,33807403 0,33895827 ! regulation of translation GO:0006417 151 100 0,000 0,34649114 0,34724602 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,34649114 0,34709478 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,34649114 0,34694367 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,34649114 0,3467927 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,34649114 0,34664185 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,34649114 0,34649114