pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/502-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 9,000 5,564E-11 1,28E-07 ! apoptotic mitochondrial changes GO:0008637 29 18 6,000 2,201E-10 2,532E-07 ! regulation of lipid kinase activity GO:0043550 12 7 4,000 1,746E-09 1,338E-06 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 7,000 7,704E-09 4,43E-06 ! interphase of mitotic cell cycle GO:0051329 156 86 9,000 1,149E-08 5,286E-06 ! interphase GO:0051325 159 88 9,000 1,44E-08 5,522E-06 ! peptide or protein amino-terminal blocking GO:0018409 14 10 4,000 2,046E-08 6,721E-06 ! N-terminal protein amino acid modification GO:0031365 18 13 4,000 1,02E-07 2,933E-05 ! N-terminal protein amino acid acetylation GO:0006474 7 6 3,000 1,306E-07 3,337E-05 ! release of cytochrome c from mitochondria GO:0001836 23 14 4,000 1,574E-07 3,621E-05 ! negative regulation of cell size GO:0045792 108 64 7,000 1,975E-07 4,13E-05 ! response to UV GO:0009411 75 46 6,000 2,941E-07 5,636E-05 ! peptidyl-amino acid modification GO:0018193 147 93 8,000 3,158E-07 5,588E-05 ! mitochondrion organization GO:0007005 104 73 7,000 5,567E-07 9,146E-05 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 3,000 6,001E-07 9,201E-05 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 3,000 6,001E-07 8,626E-05 ! negative regulation of protein kinase activity GO:0006469 99 57 6,000 1,327E-06 1,795E-04 ! negative regulation of kinase activity GO:0033673 100 58 6,000 1,497E-06 1,913E-04 ! protein amino acid acylation GO:0043543 37 21 4,000 1,514E-06 1,832E-04 ! activation of pro-apoptotic gene products GO:0008633 36 21 4,000 1,514E-06 1,741E-04 ! regulation of B cell proliferation GO:0030888 15 10 3,000 1,773E-06 1,942E-04 ! cell cycle arrest GO:0007050 150 86 7,000 1,973E-06 2,063E-04 ! negative regulation of transferase activity GO:0051348 105 61 6,000 2,119E-06 2,119E-04 ! negative regulation of cell growth GO:0030308 106 62 6,000 2,369E-06 2,271E-04 ! T cell homeostasis GO:0043029 20 11 3,000 2,765E-06 2,543E-04 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 3,088E-06 2,731E-04 ! lymphocyte homeostasis GO:0002260 24 13 3,000 5,899E-06 5,025E-04 ! negative regulation of growth GO:0045926 123 75 6,000 8,595E-06 7,06E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 9,065E-06 7,189E-04 ! nuclear migration GO:0007097 10 5 2,000 9,065E-06 6,95E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 9,065E-06 6,725E-04 GO:0031272|regulation of pseudopodium assembly, ! peptidyl-serine phosphorylation GO:0018105 23 15 3,000 1,109E-05 7,971E-04 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 3,000 1,109E-05 7,73E-04 ! aging GO:0007568 79 52 5,000 1,125E-05 7,61E-04 ! regulation of protein stability GO:0031647 48 32 4,000 1,373E-05 9,023E-04 ! protein amino acid acetylation GO:0006473 28 16 3,000 1,467E-05 9,375E-04 ! G1 phase GO:0051318 27 16 3,000 1,467E-05 9,122E-04 ! ER overload response GO:0006983 7 6 2,000 1,8E-05 1,089E-03 ! macrophage differentiation GO:0030225 10 6 2,000 1,8E-05 1,061E-03 ! negative regulation of B cell activation GO:0050869 9 6 2,000 1,8E-05 1,035E-03 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 1,868E-05 1,048E-03 ! peptidyl-serine modification GO:0018209 27 17 3,000 1,904E-05 1,043E-03 ! response to peptide hormone stimulus GO:0043434 84 57 5,000 1,926E-05 1,03E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 3,000 3,054E-05 1,597E-03 ! apoptotic nuclear changes GO:0030262 24 19 3,000 3,054E-05 1,561E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 3,127E-05 1,564E-03 ! B cell lineage commitment GO:0002326 17 7 2,000 3,127E-05 1,53E-03 ! establishment of nucleus localization GO:0040023 13 7 2,000 3,127E-05 1,498E-03 ! T cell lineage commitment GO:0002360 12 7 2,000 3,127E-05 1,468E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 4,212E-05 1,937E-03 ! response to light stimulus GO:0009416 153 96 6,000 4,346E-05 1,96E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 3,000 4,645E-05 2,054E-03 ! cell aging GO:0007569 32 21 3,000 4,645E-05 2,016E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 3,000 4,645E-05 1,978E-03 ! regulation of embryonic development GO:0045995 16 8 2,000 4,967E-05 2,077E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 5,634E-05 2,314E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 3,000 5,634E-05 2,273E-03 GO:0010810|regulation of cell-substrate adhesion, ! leukocyte homeostasis GO:0001776 33 22 3,000 5,634E-05 2,234E-03 ! response to insulin stimulus GO:0032868 63 43 4,000 6,017E-05 2,346E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 3,000 6,768E-05 2,594E-03 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 6,768E-05 2,552E-03 ! nucleus localization GO:0051647 15 9 2,000 7,397E-05 2,744E-03 ! positive regulation of cell cycle GO:0045787 77 45 4,000 7,518E-05 2,745E-03 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 8,572E-05 3,081E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 9,522E-05 3,369E-03 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of DNA replication GO:0006275 75 48 4,000 1,029E-04 3,586E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 1,049E-04 3,602E-03 ! protein sumoylation GO:0016925 12 10 2,000 1,049E-04 3,549E-03 ! filopodium assembly GO:0046847 19 11 2,000 1,432E-04 4,774E-03 ! focal adhesion formation GO:0048041 24 11 2,000 1,432E-04 4,706E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 1,432E-04 4,64E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of B cell activation GO:0050864 42 28 3,000 1,506E-04 4,812E-03 ! DNA catabolic process GO:0006308 67 54 4,000 1,813E-04 5,711E-03 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 1,852E-04 5,757E-03 ! transcription initiation GO:0006352 118 85 5,000 1,852E-04 5,681E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 1,896E-04 5,738E-03 ! histone acetylation GO:0016573 23 12 2,000 1,896E-04 5,663E-03 ! peptidyl-lysine modification GO:0018205 18 12 2,000 1,896E-04 5,591E-03 ! response to gamma radiation GO:0010332 20 12 2,000 1,896E-04 5,52E-03 ! microspike assembly GO:0030035 23 12 2,000 1,896E-04 5,451E-03 ! regulation of lipid metabolic process GO:0019216 84 56 4,000 2,155E-04 6,12E-03 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 3,000 2,263E-04 6,346E-03 ! cellular pigmentation GO:0033059 24 13 2,000 2,447E-04 6,781E-03 ! leukocyte differentiation GO:0002521 143 90 5,000 2,533E-04 6,936E-03 ! nucleus organization GO:0006997 49 33 3,000 2,898E-04 7,842E-03 ! regulation of homeostatic process GO:0032844 105 60 4,000 2,986E-04 7,986E-03 ! G1 phase of mitotic cell cycle GO:0000080 23 14 2,000 3,092E-04 8,174E-03 ! regulation of erythrocyte differentiation GO:0045646 27 14 2,000 3,092E-04 8,082E-03 ! homeostasis of number of cells GO:0048872 84 61 4,000 3,227E-04 8,34E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 3,837E-04 9,807E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 3,837E-04 9,699E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! cell cycle checkpoint GO:0000075 108 64 4,000 4,04E-04 0,0100993 ! pigmentation GO:0043473 74 38 3,000 5,033E-04 0,0124462 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 5,653E-04 0,01383185 ! cell-substrate junction assembly GO:0007044 39 17 2,000 5,653E-04 0,01368626 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 5,653E-04 0,01354369 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 4,000 6,117E-04 0,01450532 ! ATP synthesis coupled electron transport GO:0042773 48 40 3,000 6,137E-04 0,01440285 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! B cell differentiation GO:0030183 62 40 3,000 6,137E-04 0,01425736 ! regulation of myeloid cell differentiation GO:0045637 69 40 3,000 6,137E-04 0,01411479 ! positive regulation of DNA replication GO:0045740 29 18 2,000 6,735E-04 0,01533719 ! negative regulation of T cell activation GO:0050868 25 18 2,000 6,735E-04 0,01518682 ! cellular component disassembly GO:0022411 64 42 3,000 7,403E-04 0,01653063 ! protein import into nucleus GO:0006606 118 74 4,000 7,891E-04 0,01745049 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 7,941E-04 0,01739364 ! response to alkaloid GO:0043279 32 19 2,000 7,941E-04 0,01722955 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 7,941E-04 0,01706852 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 7,941E-04 0,01691048 ! protein stabilization GO:0050821 26 19 2,000 7,941E-04 0,01675534 ! activation of caspase activity GO:0006919 65 43 3,000 8,1E-04 0,0169372 ! nuclear import GO:0051170 121 75 4,000 8,388E-04 0,01738106 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 8,843E-04 0,01815991 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 9,275E-04 0,0188783 ! sleep GO:0030431 11 5 1,000 9,33E-04 0,01882315 ! rhythmic behavior GO:0007622 12 5 1,000 9,33E-04 0,01865947 ! protein maturation by protein folding GO:0022417 12 5 1,000 9,33E-04 0,01849861 ! positive regulation of glycolysis GO:0045821 11 5 1,000 9,33E-04 0,0183405 ! anagen GO:0042640 6 5 1,000 9,33E-04 0,01818508 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 9,33E-04 0,01803226 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 9,33E-04 0,01788199 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 9,33E-04 0,01773421 ! microvillus organization GO:0032528 7 5 1,000 9,33E-04 0,01758884 GO:0030033|microvillus assembly, ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 1,000 9,33E-04 0,01744584 ! response to food GO:0032094 5 5 1,000 9,33E-04 0,01730515 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 9,33E-04 0,01716671 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 9,33E-04 0,01703047 ! early endosome to late endosome transport GO:0045022 11 5 1,000 9,33E-04 0,01689637 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 9,33E-04 0,01676437 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 1,000 9,33E-04 0,01663441 ! regulation of respiratory burst GO:0060263 8 5 1,000 9,33E-04 0,01650645 ! apical protein localization GO:0045176 6 5 1,000 9,33E-04 0,01638045 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 9,33E-04 0,01625636 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 9,33E-04 0,01613413 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 9,33E-04 0,01601372 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 9,632E-04 0,0164109 ! histone modification GO:0016570 68 46 3,000 1,047E-03 0,0177069 ! oxidative phosphorylation GO:0006119 105 79 4,000 1,062E-03 0,01782161 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 1,074E-03 0,01790568 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 1,074E-03 0,01777686 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 1,074E-03 0,01764988 ! protein localization in nucleus GO:0034504 133 80 4,000 1,123E-03 0,01832635 ! respiratory electron transport chain GO:0022904 59 47 3,000 1,136E-03 0,01839629 ! covalent chromatin modification GO:0016569 75 47 3,000 1,136E-03 0,01826764 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 1,136E-03 0,01814078 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of caspase activity GO:0043280 72 48 3,000 1,23E-03 0,01950508 GO:0010952|positive regulation of peptidase activity, ! protein import into nucleus, translocation GO:0000060 36 22 2,000 1,235E-03 0,01945671 ! molting cycle process GO:0022404 40 22 2,000 1,235E-03 0,01932435 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! protein tetramerization GO:0051262 39 22 2,000 1,235E-03 0,01919378 ! regulation of cell adhesion GO:0030155 159 83 4,000 1,325E-03 0,02045914 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 1,000 1,39E-03 0,0213204 GO:0045346|regulation of MHC class II biosynthetic process, ! regulation of helicase activity GO:0051095 11 6 1,000 1,39E-03 0,0211792 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,39E-03 0,02103987 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 1,39E-03 0,02090235 GO:0031958|corticosteroid receptor signaling pathway, ! protein lipoylation GO:0009249 10 6 1,000 1,39E-03 0,02076662 ! pigment granule organization GO:0048753 11 6 1,000 1,39E-03 0,02063264 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,39E-03 0,02050038 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 1,000 1,39E-03 0,02036981 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,39E-03 0,02024088 ! neuron apoptosis GO:0051402 8 6 1,000 1,39E-03 0,02011358 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 1,39E-03 0,01998787 ! male sex determination GO:0030238 9 6 1,000 1,39E-03 0,01986373 ! positive regulation of cytokine production during immune response GO:0002720 8 6 1,000 1,39E-03 0,01974111 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 1,39E-03 0,01962 ! hair follicle maturation GO:0048820 7 6 1,000 1,39E-03 0,01950036 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,39E-03 0,01938218 ! regulation of meiosis GO:0040020 10 6 1,000 1,39E-03 0,01926542 GO:0051445|regulation of meiotic cell cycle, ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,39E-03 0,01915006 ! positive regulation of growth GO:0045927 67 50 3,000 1,434E-03 0,01962559 ! positive regulation of cell migration GO:0030335 92 51 3,000 1,544E-03 0,02101016 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 1,6E-03 0,02164881 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 1,6E-03 0,02152221 ! mitochondrial membrane organization GO:0007006 39 24 2,000 1,6E-03 0,02139708 ! establishment of organelle localization GO:0051656 85 52 3,000 1,66E-03 0,02206707 ! cell projection assembly GO:0030031 76 53 3,000 1,782E-03 0,0235524 ! regulation of chromosome organization GO:0033044 35 25 2,000 1,805E-03 0,02372738 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,805E-03 0,02359257 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,934E-03 0,02513285 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,934E-03 0,02499165 ! protein-cofactor linkage GO:0018065 13 7 1,000 1,934E-03 0,02485204 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,934E-03 0,02471397 ! asymmetric protein localization GO:0008105 8 7 1,000 1,934E-03 0,02457743 ! organ growth GO:0035265 11 7 1,000 1,934E-03 0,02444239 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 1,934E-03 0,02430882 ! behavioral fear response GO:0001662 13 7 1,000 1,934E-03 0,02417671 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 1,934E-03 0,02404602 ! response to UV-B GO:0010224 11 7 1,000 1,934E-03 0,02391674 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,934E-03 0,02378885 ! regulation of circadian rhythm GO:0042752 11 7 1,000 1,934E-03 0,02366231 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 1,000 1,934E-03 0,02353711 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 1,934E-03 0,02341323 ! synaptic vesicle endocytosis GO:0048488 16 7 1,000 1,934E-03 0,02329065 ! response to tumor cell GO:0002347 12 7 1,000 1,934E-03 0,02316935 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,934E-03 0,0230493 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,934E-03 0,02293049 ! positive regulation of cell motion GO:0051272 99 56 3,000 2,185E-03 0,02576903 ! response to ionizing radiation GO:0010212 47 27 2,000 2,263E-03 0,02655886 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 2,263E-03 0,02642404 ! negative regulation of transcription regulator activity GO:0090048 47 27 2,000 2,263E-03 0,02629059 GO:0043433|negative regulation of transcription factor activity, ! response to oxidative stress GO:0006979 141 94 4,000 2,299E-03 0,02657472 ! regulation of binding GO:0051098 151 95 4,000 2,408E-03 0,02769382 ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 2,486E-03 0,02844504 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 2,517E-03 0,02865656 ! cell junction assembly GO:0034329 56 28 2,000 2,517E-03 0,02851539 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 2,517E-03 0,02837561 ! positive regulation of catabolic process GO:0009896 40 28 2,000 2,517E-03 0,0282372 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,562E-03 0,0286081 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 2,562E-03 0,0284699 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 2,562E-03 0,02833303 ! middle ear morphogenesis GO:0042474 9 8 1,000 2,562E-03 0,02819746 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 2,562E-03 0,02806319 ! melanin metabolic process GO:0006582 12 8 1,000 2,562E-03 0,02793019 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 2,562E-03 0,02779844 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 2,562E-03 0,02766793 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 2,562E-03 0,02753864 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 1,000 2,562E-03 0,02741056 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 2,562E-03 0,02728366 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 2,562E-03 0,02715792 ! regulation of telomere maintenance GO:0032204 10 8 1,000 2,562E-03 0,02703335 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 4,000 2,637E-03 0,02769521 ! actin filament organization GO:0007015 95 59 3,000 2,647E-03 0,02766872 ! myeloid cell differentiation GO:0030099 85 59 3,000 2,647E-03 0,02754352 ! protein import GO:0017038 156 99 4,000 2,881E-03 0,02985186 ! cell-matrix adhesion GO:0007160 114 61 3,000 2,989E-03 0,0308296 ! protein localization in organelle GO:0033365 161 100 4,000 3,009E-03 0,03090057 ! negative regulation of cell activation GO:0050866 44 30 2,000 3,075E-03 0,03143137 ! response to heat GO:0009408 41 30 2,000 3,075E-03 0,03129229 ! organelle localization GO:0051640 96 62 3,000 3,171E-03 0,03213169 ! regulation of developmental growth GO:0048638 13 9 1,000 3,273E-03 0,03301951 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 3,273E-03 0,03287532 ! positive regulation of GTPase activity GO:0043547 21 9 1,000 3,273E-03 0,03273239 ! regulation of activated T cell proliferation GO:0046006 15 9 1,000 3,273E-03 0,03259069 ! regulation of glycolysis GO:0006110 15 9 1,000 3,273E-03 0,03245021 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 3,273E-03 0,03231094 ! T cell selection GO:0045058 18 9 1,000 3,273E-03 0,03217286 ! receptor clustering GO:0043113 15 9 1,000 3,273E-03 0,03203595 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 3,273E-03 0,03190021 ! positive regulation of phagocytosis GO:0050766 11 9 1,000 3,273E-03 0,03176561 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 1,000 3,273E-03 0,03163214 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 3,273E-03 0,03149979 ! oocyte differentiation GO:0009994 12 9 1,000 3,273E-03 0,03136854 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 3,273E-03 0,03123838 ! spleen development GO:0048536 15 9 1,000 3,273E-03 0,03110929 ! sequestering of metal ion GO:0051238 11 9 1,000 3,273E-03 0,03098127 ! response to nicotine GO:0035094 16 9 1,000 3,273E-03 0,0308543 ! regulation of transcription factor activity GO:0051090 97 63 3,000 3,361E-03 0,03155047 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 3,000 3,361E-03 0,03142222 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 3,38E-03 0,03147377 ! regulation of muscle development GO:0048634 48 32 2,000 3,703E-03 0,03434344 ! mitotic sister chromatid segregation GO:0000070 45 32 2,000 3,703E-03 0,03420551 ! regulation of caspase activity GO:0043281 97 65 3,000 3,763E-03 0,03461747 ! B cell activation GO:0042113 104 65 3,000 3,763E-03 0,03447955 ! cell-substrate adhesion GO:0031589 121 66 3,000 3,975E-03 0,03628391 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 4,044E-03 0,03676773 ! sister chromatid segregation GO:0000819 46 33 2,000 4,044E-03 0,03662298 ! cell junction organization GO:0034330 63 33 2,000 4,044E-03 0,03647936 ! negative regulation of DNA binding GO:0043392 54 33 2,000 4,044E-03 0,03633686 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 4,044E-03 0,03619547 ! negative regulation of muscle development GO:0048635 12 10 1,000 4,065E-03 0,03624122 ! cortical actin cytoskeleton organization GO:0030866 19 10 1,000 4,065E-03 0,03610129 ! hair follicle morphogenesis GO:0031069 17 10 1,000 4,065E-03 0,03596244 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 4,065E-03 0,03582465 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 4,065E-03 0,03568792 GO:0010812|negative regulation of cell-substrate adhesion, ! glucan biosynthetic process GO:0009250 13 10 1,000 4,065E-03 0,03555222 GO:0005978|glycogen biosynthetic process, ! response to X-ray GO:0010165 16 10 1,000 4,065E-03 0,03541755 ! B cell proliferation GO:0042100 14 10 1,000 4,065E-03 0,0352839 ! fear response GO:0042596 16 10 1,000 4,065E-03 0,03515125 ! negative regulation of ossification GO:0030279 19 10 1,000 4,065E-03 0,0350196 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 4,065E-03 0,03488893 ! alpha-beta T cell activation GO:0046631 16 10 1,000 4,065E-03 0,03475923 ! DNA methylation GO:0006306 15 10 1,000 4,065E-03 0,0346305 GO:0006305|DNA alkylation, ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 4,065E-03 0,03450271 GO:0043470|regulation of carbohydrate catabolic process, ! T cell receptor signaling pathway GO:0050852 18 10 1,000 4,065E-03 0,03437586 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 4,065E-03 0,03424994 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 4,196E-03 0,03522301 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 4,404E-03 0,03683601 ! response to drug GO:0042493 108 69 3,000 4,662E-03 0,03885009 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 4,783E-03 0,03971419 ! glycogen metabolic process GO:0005977 48 35 2,000 4,783E-03 0,03957133 ! regulation of catabolic process GO:0009894 106 70 3,000 4,907E-03 0,04045594 ! cortical cytoskeleton organization GO:0030865 20 11 1,000 4,937E-03 0,04055307 ! virus-host interaction GO:0019048 17 11 1,000 4,937E-03 0,04040875 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,937E-03 0,04026546 ! detection of mechanical stimulus GO:0050982 15 11 1,000 4,937E-03 0,04012318 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 4,937E-03 0,0399819 ! regulation of intracellular pH GO:0051453 17 11 1,000 4,937E-03 0,03984161 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 4,937E-03 0,03970231 ! regulation of phagocytosis GO:0050764 14 11 1,000 4,937E-03 0,03956397 ! positive regulation of T cell mediated immunity GO:0002711 18 11 1,000 4,937E-03 0,0394266 ! histone deacetylation GO:0016575 13 11 1,000 4,937E-03 0,03929017 ! digestive tract morphogenesis GO:0048546 15 11 1,000 4,937E-03 0,03915469 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! lymphocyte differentiation GO:0030098 113 71 3,000 5,161E-03 0,04079523 ! response to reactive oxygen species GO:0000302 55 36 2,000 5,181E-03 0,04080701 ! negative regulation of binding GO:0051100 58 36 2,000 5,181E-03 0,04066774 ! glucan metabolic process GO:0044042 49 36 2,000 5,181E-03 0,04052941 GO:0006073|cellular glucan metabolic process, ! regulation of peptidase activity GO:0052547 106 72 3,000 5,424E-03 0,04228997 ! response to hypoxia GO:0001666 132 72 3,000 5,424E-03 0,0421471 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 5,886E-03 0,04558457 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 5,886E-03 0,0454316 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! gland morphogenesis GO:0022612 23 12 1,000 5,886E-03 0,04527966 ! response to oxygen levels GO:0070482 137 74 3,000 5,976E-03 0,04581583 ! regulation of T cell proliferation GO:0042129 58 38 2,000 6,034E-03 0,04611064 ! developmental growth GO:0048589 62 39 2,000 6,491E-03 0,04943458 ! regulation of DNA binding GO:0051101 119 77 3,000 6,872E-03 0,05216256 ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 6,912E-03 0,05229557 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 6,912E-03 0,05212411 ! regulation of cytokine production during immune response GO:0002718 18 13 1,000 6,912E-03 0,05195377 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 6,912E-03 0,05178454 ! regulation of cellular pH GO:0030641 20 13 1,000 6,912E-03 0,05161641 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 6,912E-03 0,05144936 ! T cell differentiation GO:0030217 65 40 2,000 6,968E-03 0,05169444 ! positive regulation of protein transport GO:0051222 55 40 2,000 6,968E-03 0,05152822 ! energy reserve metabolic process GO:0006112 59 41 2,000 7,464E-03 0,05502528 ! glucose transport GO:0015758 52 41 2,000 7,464E-03 0,05484948 ! cellular respiration GO:0045333 107 79 3,000 7,516E-03 0,05505302 ! mitochondrial transport GO:0006839 60 42 2,000 7,982E-03 0,05827784 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 7,982E-03 0,05809342 ! hexose transport GO:0008645 54 42 2,000 7,982E-03 0,05791016 GO:0015749|monosaccharide transport, ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 8,013E-03 0,05795273 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 8,013E-03 0,05777106 ! epidermis morphogenesis GO:0048730 29 14 1,000 8,013E-03 0,05759052 ! cellular response to starvation GO:0009267 21 14 1,000 8,013E-03 0,05741111 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 8,013E-03 0,05723282 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 8,013E-03 0,05705562 ! G1/S transition checkpoint GO:0031575 33 14 1,000 8,013E-03 0,05687953 ! intermediate filament-based process GO:0045103 24 14 1,000 8,013E-03 0,05670451 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 8,013E-03 0,05653057 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 1,000 8,013E-03 0,0563577 ! regulation of cell cycle process GO:0010564 122 81 3,000 8,199E-03 0,05749002 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 8,519E-03 0,05955806 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 8,519E-03 0,05937758 ! regulation of cell projection organization GO:0031344 83 44 2,000 9,078E-03 0,06308015 ! metencephalon development GO:0022037 19 15 1,000 9,186E-03 0,06363979 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 9,186E-03 0,06344868 ! positive regulation of proteolysis GO:0045862 19 15 1,000 9,186E-03 0,06325871 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 9,186E-03 0,06306988 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 9,186E-03 0,06288217 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 9,186E-03 0,06269558 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 9,186E-03 0,06251009 ! defense response to virus GO:0051607 27 15 1,000 9,186E-03 0,06232569 ! regulation of protein localization GO:0032880 132 85 3,000 9,683E-03 0,06550334 ! regulation of ossification GO:0030278 71 46 2,000 0,01025843 0,06919176 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 0,0104316 0,07015405 ! protein amino acid deacetylation GO:0006476 20 16 1,000 0,0104316 0,06994952 ! mitotic chromosome condensation GO:0007076 25 16 1,000 0,0104316 0,06974618 ! cellular response to unfolded protein GO:0034620 19 16 1,000 0,0104316 0,06954401 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of protein binding GO:0043393 27 16 1,000 0,0104316 0,06934302 ! protein export from nucleus GO:0006611 24 16 1,000 0,0104316 0,06914318 ! DNA replication initiation GO:0006270 25 16 1,000 0,0104316 0,0689445 ! oogenesis GO:0048477 23 16 1,000 0,0104316 0,06874695 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 0,0104316 0,06855053 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 0,0104316 0,06835523 ! negative regulation of translation GO:0017148 22 16 1,000 0,0104316 0,06816104 ! response to estrogen stimulus GO:0043627 74 47 2,000 0,01088043 0,07089232 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 2,000 0,01088043 0,07069206 ! negative regulation of immune system process GO:0002683 73 47 2,000 0,01088043 0,07049292 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 0,01088043 0,07029491 ! regulation of T cell activation GO:0050863 128 89 3,000 0,01133221 0,07300864 ! regulation of neurogenesis GO:0050767 153 89 3,000 0,01133221 0,07280471 ! response to temperature stimulus GO:0009266 62 48 2,000 0,01152381 0,07382945 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 0,01152381 0,07362436 ! regulation of endocytosis GO:0030100 63 48 2,000 0,01152381 0,07342042 ! signal complex assembly GO:0007172 29 17 1,000 0,01174711 0,07463633 ! regulation of viral genome replication GO:0045069 24 17 1,000 0,01174711 0,07443072 ! actin filament bundle formation GO:0051017 26 17 1,000 0,01174711 0,07422624 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 0,01174711 0,07402288 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 0,01174711 0,07382063 ! protein modification by small protein conjugation GO:0032446 140 90 3,000 0,01177095 0,07376888 ! RNA elongation GO:0006354 62 49 2,000 0,0121887 0,07617938 ! regulation of intracellular transport GO:0032386 78 49 2,000 0,0121887 0,07597294 ! germ cell development GO:0007281 68 49 2,000 0,0121887 0,0757676 ! maintenance of location GO:0051235 84 49 2,000 0,0121887 0,07556338 ! cell fate commitment GO:0045165 141 92 3,000 0,01268082 0,07840293 ! positive regulation of immune response GO:0050778 121 92 3,000 0,01268082 0,07819273 ! ear development GO:0043583 72 50 2,000 0,0128752 0,07917905 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 0,0128752 0,07896791 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 0,01313131 0,0803245 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 1,000 0,01313131 0,08011144 ! somitogenesis GO:0001756 24 18 1,000 0,01313131 0,0798995 ! synaptic vesicle transport GO:0048489 33 18 1,000 0,01313131 0,07968869 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 1,000 0,01313131 0,07947898 ! cellular response to nutrient levels GO:0031669 27 18 1,000 0,01313131 0,07927037 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 0,01313131 0,07906286 ! gut development GO:0048565 26 18 1,000 0,01313131 0,07885643 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 0,01313131 0,07865107 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 0,01313131 0,07844678 ! regulation of protein catabolic process GO:0042176 77 51 2,000 0,01358342 0,08093745 ! electron transport chain GO:0022900 123 94 3,000 0,01363449 0,08103183 ! nucleotide-excision repair GO:0006289 64 52 2,000 0,01431343 0,08484766 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,01458275 0,08622192 ! regeneration GO:0031099 32 19 1,000 0,01458275 0,08600084 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 0,01458275 0,08578089 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 0,01458275 0,08556206 ! response to starvation GO:0042594 30 19 1,000 0,01458275 0,08534434 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 0,01458275 0,08512773 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 0,01458275 0,08491222 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 0,01458275 0,0846978 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 0,01458275 0,08448445 ! sex determination GO:0007530 29 19 1,000 0,01458275 0,08427218 ! cytolysis GO:0019835 20 19 1,000 0,01458275 0,08406097 ! renal system process GO:0003014 35 19 1,000 0,01458275 0,08385082 ! regulation of interleukin-2 production GO:0032663 31 19 1,000 0,01458275 0,08364171 ! protein modification by small protein conjugation or removal GO:0070647 148 96 3,000 0,01463261 0,08371893 ! protein maturation GO:0051604 129 96 3,000 0,01463261 0,08351119 ! regulation of bone remodeling GO:0046850 90 53 2,000 0,01506533 0,08576797 ! regulation of protein complex assembly GO:0043254 81 54 2,000 0,01583918 0,08995091 ! regulation of tissue remodeling GO:0034103 91 54 2,000 0,01583918 0,08972936 ! response to ethanol GO:0045471 37 20 1,000 0,0161 0,09098281 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,0161 0,09075981 ! chromosome condensation GO:0030261 31 20 1,000 0,0161 0,0905379 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 0,0161 0,09031708 ! DNA modification GO:0006304 28 20 1,000 0,0161 0,09009733 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,0161 0,08987865 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 0,01768165 0,09846924 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 0,01768165 0,09823139 ! ovarian follicle development GO:0001541 30 21 1,000 0,01768165 0,09799469 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01768165 0,09775912 ! positive regulation of adaptive immune response GO:0002821 31 21 1,000 0,01768165 0,09752469 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01768165 0,09729137 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01768165 0,09705918 ! carbohydrate transport GO:0008643 74 57 2,000 0,01829305 0,10017623 ! chromosome segregation GO:0007059 83 57 2,000 0,01829305 0,09993828 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01932631 0,10533295 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 0,01932631 0,10508394 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! ureteric bud development GO:0001657 32 22 1,000 0,01932631 0,1048361 ! neural tube closure GO:0001843 33 22 1,000 0,01932631 0,10458943 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of vesicle-mediated transport GO:0060627 79 60 2,000 0,02094625 0,1130901 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,0210326 0,11329037 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,0210326 0,11302568 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,0210326 0,11276221 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,0210326 0,11249997 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,0210326 0,11223895 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,0210326 0,11197914 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,0210326 0,11172053 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,0210326 0,11146311 ! interaction with host GO:0051701 37 23 1,000 0,0210326 0,11120687 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,0210326 0,11095181 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,0210326 0,11069792 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,0210326 0,11044518 ! fat cell differentiation GO:0045444 37 24 1,000 0,02279919 0,11944907 ! receptor metabolic process GO:0043112 37 24 1,000 0,02279919 0,1191776 ! response to toxin GO:0009636 38 24 1,000 0,02279919 0,11890735 ! primary neural tube formation GO:0014020 35 24 1,000 0,02279919 0,11863833 ! negative regulation of cell development GO:0010721 56 24 1,000 0,02279919 0,11837053 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 0,02279919 0,11810393 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 1,000 0,02279919 0,11783852 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,02279919 0,11757431 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,02279919 0,11731128 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,02462474 0,12642168 ! male gonad development GO:0008584 33 25 1,000 0,02462474 0,12614012 ! iron ion homeostasis GO:0055072 39 25 1,000 0,02462474 0,12585981 ! response to estradiol stimulus GO:0032355 34 25 1,000 0,02462474 0,12558074 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,02462474 0,1253029 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,02462474 0,1250263 ! leukocyte proliferation GO:0070661 39 25 1,000 0,02462474 0,12475091 GO:0032943|mononuclear cell proliferation, ! activation of immune response GO:0002253 83 65 2,000 0,02581254 0,13048097 ! protein oligomerization GO:0051259 100 65 2,000 0,02581254 0,13019482 ! regulation of pH GO:0006885 36 26 1,000 0,02650795 0,13340982 ! circadian rhythm GO:0007623 42 26 1,000 0,02650795 0,13311854 ! post-embryonic development GO:0009791 42 26 1,000 0,02650795 0,13282852 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 0,02650795 0,13253976 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,02791441 0,1392693 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 1,000 0,02844753 0,14162188 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 1,000 0,02844753 0,141316 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,02844753 0,14101144 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,02844753 0,14070819 ! rhythmic process GO:0048511 105 68 2,000 0,02899854 0,14312585 ! positive regulation of endocytosis GO:0045807 33 28 1,000 0,0304422 0,14992945 ! complement activation, classical pathway GO:0006958 36 28 1,000 0,0304422 0,14960909 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,0304422 0,14929009 ! immune response-activating signal transduction GO:0002757 38 28 1,000 0,0304422 0,14897246 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 1,000 0,0304422 0,14865617 ! neural tube formation GO:0001841 41 28 1,000 0,0304422 0,14834122 ! placenta development GO:0001890 37 28 1,000 0,0304422 0,1480276 ! response to metal ion GO:0010038 103 70 2,000 0,03123298 0,15155245 ! humoral immune response GO:0006959 86 70 2,000 0,03123298 0,1512334 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,03249072 0,15699296 ! ovulation cycle process GO:0022602 41 29 1,000 0,03249072 0,15666384 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,03249072 0,15633609 ! tissue homeostasis GO:0001894 42 29 1,000 0,03249072 0,15600971 GO:0048871|multicellular organismal homeostasis, ! spindle organization GO:0007051 37 30 1,000 0,03459185 0,16575263 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 0,03459185 0,16540803 ! ovulation cycle GO:0042698 43 30 1,000 0,03459185 0,16506486 ! hindbrain development GO:0030902 45 30 1,000 0,03459185 0,16472311 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,03459185 0,16438277 ! positive regulation of immune effector process GO:0002699 40 30 1,000 0,03459185 0,16404384 ! tube morphogenesis GO:0035239 118 73 2,000 0,03474932 0,16445151 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,03474932 0,16411382 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,03596509 0,16950761 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,03674439 0,1728264 ! mammary gland development GO:0030879 57 31 1,000 0,03674439 0,17247369 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,03674439 0,17212242 ! segmentation GO:0035282 41 31 1,000 0,03674439 0,17177258 ! metanephros development GO:0001656 58 31 1,000 0,03674439 0,17142415 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,03674439 0,17107714 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,03674439 0,17073153 ! response to inorganic substance GO:0010035 115 75 2,000 0,03720258 0,17251197 ! regulation of protein transport GO:0051223 114 76 2,000 0,0384617 0,17799178 GO:0070201|regulation of establishment of protein localization, ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,03894715 0,17987638 ! meiosis I GO:0007127 52 32 1,000 0,03894715 0,1795159 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,03894715 0,17915687 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,03894715 0,17879927 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,03894715 0,1784431 ! gland development GO:0048732 148 77 2,000 0,03974237 0,18172456 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,04119893 0,188011 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,04119893 0,1876387 ! ear morphogenesis GO:0042471 42 33 1,000 0,04119893 0,18726788 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 1,000 0,04119893 0,18689851 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,04119893 0,1865306 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 1,000 0,04119893 0,18616414 ! positive regulation of cell development GO:0010720 54 33 1,000 0,04119893 0,18579911 ! regulation of proteolysis GO:0030162 50 33 1,000 0,04119893 0,18543551 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,04119893 0,18507333 ! cytokinesis GO:0000910 52 33 1,000 0,04119893 0,18471257 ! T cell activation GO:0042110 134 79 2,000 0,042368 0,18958442 ! feeding behavior GO:0007631 45 34 1,000 0,0434986 0,19426558 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,0434986 0,1938891 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,0434986 0,19351407 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,0434986 0,19314049 ! neuron migration GO:0001764 46 34 1,000 0,0434986 0,19276835 ! female gamete generation GO:0007292 43 34 1,000 0,0434986 0,19239764 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,0434986 0,19202836 ! response to protein stimulus GO:0051789 111 81 2,000 0,04507869 0,19862259 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,04507869 0,19824281 GO:0002696|positive regulation of leukocyte activation, ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,045845 0,20122805 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,045845 0,20084476 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 1,000 0,045845 0,20046292 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 1,000 0,045845 0,20008254 ! pigment metabolic process GO:0042440 61 35 1,000 0,045845 0,19970359 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,045845 0,19932608 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04796537 0,20815159 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04796537 0,20775959 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04796537 0,20736906 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04796537 0,20698 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04796537 0,2065924 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04796537 0,20620624 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04796537 0,20582153 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04796537 0,20543825 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,04796537 0,2050564 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04796537 0,20467596 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04796537 0,20429693 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04796537 0,2039193 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04796537 0,20354306 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04796537 0,20316822 ! tongue development GO:0043586 6 5 0,000 0,04796537 0,20279474 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04796537 0,20242264 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04796537 0,20205191 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04796537 0,20168252 ! cobalt ion transport GO:0006824 9 5 0,000 0,04796537 0,20131449 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04796537 0,2009478 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04796537 0,20058244 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04796537 0,2002184 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04796537 0,19985569 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04796537 0,19949429 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04796537 0,19913419 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04796537 0,19877539 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04796537 0,19841788 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04796537 0,19806165 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04796537 0,1977067 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04796537 0,19735303 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,04796537 0,19700061 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04796537 0,19664945 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04796537 0,19629954 ! malate metabolic process GO:0006108 7 5 0,000 0,04796537 0,19595087 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04796537 0,19560344 ! behavioral response to pain GO:0048266 7 5 0,000 0,04796537 0,19525724 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04796537 0,19491226 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04796537 0,1945685 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04796537 0,19422595 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04796537 0,19388461 ! mating behavior GO:0007617 6 5 0,000 0,04796537 0,19354446 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04796537 0,1932055 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04796537 0,19286773 ! copulation GO:0007620 7 5 0,000 0,04796537 0,19253114 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04796537 0,19219572 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,04796537 0,19186146 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04796537 0,19152837 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04796537 0,19119643 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04796537 0,19086564 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04796537 0,19053599 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04796537 0,19020748 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04796537 0,18988011 ! response to protozoan GO:0001562 9 5 0,000 0,04796537 0,18955385 ! lymph vessel development GO:0001945 7 5 0,000 0,04796537 0,18922872 ! endochondral ossification GO:0001958 12 5 0,000 0,04796537 0,18890469 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04796537 0,18858178 ! parathyroid gland development GO:0060017 8 5 0,000 0,04796537 0,18825997 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04796537 0,18793925 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,04796537 0,18761963 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04796537 0,18730109 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04796537 0,18698363 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04796537 0,18666724 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04796537 0,18635193 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04796537 0,18603767 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04796537 0,18572448 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,04796537 0,18541234 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04796537 0,18510124 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,04796537 0,18479119 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04796537 0,18448218 ! ovulation GO:0030728 6 5 0,000 0,04796537 0,18417419 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04796537 0,18386724 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,04796537 0,1835613 ! response to pH GO:0009268 9 5 0,000 0,04796537 0,18325638 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04796537 0,18295247 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04796537 0,18264957 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04796537 0,18234767 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04796537 0,18204677 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04796537 0,18174686 ! polyol catabolic process GO:0046174 7 5 0,000 0,04796537 0,18144793 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04796537 0,18114999 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04796537 0,18085302 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04796537 0,18055702 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04796537 0,180262 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04796537 0,17996793 ! urea metabolic process GO:0019627 6 5 0,000 0,04796537 0,17967482 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04796537 0,17938267 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04796537 0,17909146 ! neutrophil activation GO:0042119 5 5 0,000 0,04796537 0,1788012 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04796537 0,17851188 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04796537 0,17822349 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04796537 0,17793603 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04796537 0,1776495 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04796537 0,17736389 ! forebrain neuron development GO:0021884 7 5 0,000 0,04796537 0,1770792 ! melanosome organization GO:0032438 7 5 0,000 0,04796537 0,17679542 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04796537 0,17651255 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04796537 0,17623058 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04796537 0,17594951 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04796537 0,17566933 ! nucleoside transport GO:0015858 6 5 0,000 0,04796537 0,17539005 ! nucleoside salvage GO:0043174 7 5 0,000 0,04796537 0,17511165 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04796537 0,17483414 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04796537 0,1745575 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04796537 0,17428174 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04796537 0,17400685 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04796537 0,17373282 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04796537 0,17345966 ! depyrimidination GO:0045008 8 5 0,000 0,04796537 0,17318735 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04796537 0,1729159 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04796537 0,17264529 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04796537 0,17237553 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04796537 0,17210662 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04796537 0,17183854 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04796537 0,17157129 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,04796537 0,17130488 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04796537 0,17103929 ! monocyte differentiation GO:0030224 8 5 0,000 0,04796537 0,17077452 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04796537 0,17051057 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04796537 0,17024744 ! centrosome duplication GO:0051298 5 5 0,000 0,04796537 0,16998512 ! response to UV-C GO:0010225 6 5 0,000 0,04796537 0,1697236 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04796537 0,16946289 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04796537 0,16920298 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04796537 0,16894386 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04796537 0,16868554 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04796537 0,168428 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04796537 0,16817125 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04796537 0,16791528 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04796537 0,16766009 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04796537 0,16740568 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04796537 0,16715203 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,04796537 0,16689915 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04796537 0,16664704 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04796537 0,16639569 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04796537 0,16614509 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04796537 0,16589525 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04796537 0,16564616 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04796537 0,16539781 ! neural tube patterning GO:0021532 6 5 0,000 0,04796537 0,16515021 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04796537 0,16490335 ! histone demethylation GO:0016577 9 5 0,000 0,04796537 0,16465723 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04796537 0,16441183 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04796537 0,16416717 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,04796537 0,16392324 ! enteric nervous system development GO:0048484 8 5 0,000 0,04796537 0,16368003 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04796537 0,16343754 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04796537 0,16319577 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04796537 0,16295471 ! transcription termination GO:0006353 8 5 0,000 0,04796537 0,16271437 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04796537 0,16247473 ! plasminogen activation GO:0031639 5 5 0,000 0,04796537 0,1622358 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04796537 0,16199756 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04796537 0,16176003 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04796537 0,16152319 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04796537 0,16128705 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04796537 0,16105159 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04796537 0,16081682 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04796537 0,16058274 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04796537 0,16034933 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04796537 0,16011661 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04796537 0,15988455 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04796537 0,15965317 ! glial cell migration GO:0008347 10 5 0,000 0,04796537 0,15942246 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04796537 0,15919241 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04796537 0,15896303 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04796537 0,1587343 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04796537 0,15850624 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04796537 0,15827882 ! neural plate development GO:0001840 6 5 0,000 0,04796537 0,15805206 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,04796537 0,15782595 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04796537 0,15760049 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04796537 0,15737566 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04796537 0,15715148 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04796537 0,15692794 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04796537 0,15670503 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04796537 0,15648275 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04796537 0,15626111 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04796537 0,15604009 ! spindle assembly GO:0051225 5 5 0,000 0,04796537 0,15581969 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04796537 0,15559992 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04796537 0,15538076 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04796537 0,15516222 ! organ regeneration GO:0031100 7 5 0,000 0,04796537 0,1549443 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04796537 0,15472699 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04796537 0,15451028 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04796537 0,15429418 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04796537 0,15407869 GO:0055081|anion homeostasis, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,04823702 0,1547352 GO:0090047|positive regulation of transcription regulator activity, ! neural tube development GO:0021915 50 36 1,000 0,04823702 0,15451969 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,04823702 0,15430478 GO:0046660|female sex differentiation, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 0,05067354 0,16187381 GO:0006956|complement activation, ! learning GO:0007612 67 37 1,000 0,05067354 0,1616493 ! ion transmembrane transport GO:0034220 56 37 1,000 0,05067354 0,16142541 ! amino acid activation GO:0043038 52 37 1,000 0,05067354 0,16120214 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! gliogenesis GO:0042063 71 38 1,000 0,05315349 0,16885777 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,05315349 0,16862486 ! mesenchymal cell development GO:0014031 64 38 1,000 0,05315349 0,1683926 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 0,05315349 0,16816097 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,0537125 0,16969608 ! protein processing GO:0016485 114 88 2,000 0,05522338 0,17423015 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,05567579 0,17541687 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 0,05567579 0,1751769 ! male sex differentiation GO:0046661 53 39 1,000 0,05567579 0,17493759 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,05567579 0,17469893 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,05567579 0,17446092 ! reproductive developmental process GO:0003006 127 89 2,000 0,05675447 0,17759902 ! tRNA transcription GO:0009304 11 6 0,000 0,05728035 0,17900108 ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,05728035 0,17875821 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05728035 0,17851599 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05728035 0,17827442 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05728035 0,17803351 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05728035 0,17779325 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,05728035 0,17755364 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05728035 0,17731467 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05728035 0,17707634 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05728035 0,17683865 ! prostate gland development GO:0030850 9 6 0,000 0,05728035 0,1766016 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05728035 0,17636519 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05728035 0,17612941 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05728035 0,17589426 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,05728035 0,17565973 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05728035 0,17542583 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05728035 0,17519255 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05728035 0,17495989 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05728035 0,17472785 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,05728035 0,17449642 ! neuron adhesion GO:0007158 9 6 0,000 0,05728035 0,1742656 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05728035 0,1740354 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05728035 0,1738058 ! signal peptide processing GO:0006465 8 6 0,000 0,05728035 0,17357681 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05728035 0,17334842 ! mRNA stabilization GO:0048255 15 6 0,000 0,05728035 0,17312063 GO:0043489|RNA stabilization, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05728035 0,17289343 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05728035 0,17266684 ! opsonization GO:0008228 8 6 0,000 0,05728035 0,17244083 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05728035 0,17221542 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05728035 0,1719906 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05728035 0,17176636 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05728035 0,1715427 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05728035 0,17131963 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05728035 0,17109714 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05728035 0,17087522 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05728035 0,17065388 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05728035 0,17043311 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05728035 0,17021292 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05728035 0,16999329 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05728035 0,16977422 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05728035 0,16955572 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05728035 0,16933779 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05728035 0,16912041 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05728035 0,16890359 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05728035 0,16868732 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05728035 0,16847161 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,05728035 0,16825645 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,05728035 0,16804183 ! thymic T cell selection GO:0045061 12 6 0,000 0,05728035 0,16782777 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05728035 0,16761425 ! drug transport GO:0015893 6 6 0,000 0,05728035 0,16740127 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05728035 0,16718883 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05728035 0,16697693 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05728035 0,16676557 ! histidine metabolic process GO:0006547 6 6 0,000 0,05728035 0,16655474 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05728035 0,16634444 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,05728035 0,16613467 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,05728035 0,16592544 ! adenohypophysis development GO:0021984 10 6 0,000 0,05728035 0,16571673 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05728035 0,16550854 ! hyperosmotic response GO:0006972 8 6 0,000 0,05728035 0,16530087 ! microtubule nucleation GO:0007020 10 6 0,000 0,05728035 0,16509373 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05728035 0,16488711 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05728035 0,164681 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05728035 0,1644754 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,05728035 0,16427032 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,05728035 0,16406575 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,05728035 0,16386169 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05728035 0,16365813 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,05728035 0,16345508 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05728035 0,16325254 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,05728035 0,16305049 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,05728035 0,16284895 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,05728035 0,1626479 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05728035 0,16244735 ! organic alcohol transport GO:0015850 9 6 0,000 0,05728035 0,16224729 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05728035 0,16204772 ! carnitine transport GO:0015879 8 6 0,000 0,05728035 0,16184865 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05728035 0,16165006 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05728035 0,16145196 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05728035 0,16125434 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05728035 0,16105721 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05728035 0,16086056 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05728035 0,16066439 ! parturition GO:0007567 12 6 0,000 0,05728035 0,16046869 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05728035 0,16027348 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05728035 0,16007873 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05728035 0,15988446 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,05728035 0,15969066 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,05728035 0,15949733 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05728035 0,15930447 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,05728035 0,15911207 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05728035 0,15892014 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,05728035 0,15872867 ! astrocyte development GO:0014002 14 6 0,000 0,05728035 0,15853766 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05728035 0,15834711 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05728035 0,15815702 ! interaction with symbiont GO:0051702 8 6 0,000 0,05728035 0,15796738 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05728035 0,1577782 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05728035 0,15758947 ! eating behavior GO:0042755 6 6 0,000 0,05728035 0,15740119 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05728035 0,15721336 ! response to copper ion GO:0046688 9 6 0,000 0,05728035 0,15702598 ! DNA topological change GO:0006265 8 6 0,000 0,05728035 0,15683904 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05728035 0,15665255 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05728035 0,15646651 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05728035 0,1562809 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05728035 0,15609573 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05728035 0,155911 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,05728035 0,15572671 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05728035 0,15554285 ! gas homeostasis GO:0033483 11 6 0,000 0,05728035 0,15535943 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05728035 0,15517644 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05728035 0,15499388 ! Schwann cell development GO:0014044 14 6 0,000 0,05728035 0,15481175 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05728035 0,15463004 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,05728035 0,15444877 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05728035 0,15426791 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05728035 0,15408748 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05728035 0,15390747 ! histone ubiquitination GO:0016574 7 6 0,000 0,05728035 0,15372788 ! G2 phase GO:0051319 13 6 0,000 0,05728035 0,15354871 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05728035 0,15336996 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05728035 0,15319162 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05728035 0,1530137 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05728035 0,15283619 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05728035 0,15265909 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05728035 0,1524824 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05728035 0,15230612 ! receptor internalization GO:0031623 9 6 0,000 0,05728035 0,15213025 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05728035 0,15195478 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05728035 0,15177972 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,05728035 0,15160506 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05728035 0,1514308 ! protein deubiquitination GO:0016579 8 6 0,000 0,05728035 0,15125694 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05728035 0,15108348 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,05728035 0,15091042 ! axonal fasciculation GO:0007413 9 6 0,000 0,05728035 0,15073775 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05728035 0,15056548 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05728035 0,1503936 ! midbrain development GO:0030901 6 6 0,000 0,05728035 0,15022212 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05728035 0,15005102 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05728035 0,14988032 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05728035 0,14971 ! progesterone metabolic process GO:0042448 8 6 0,000 0,05728035 0,14954006 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05728035 0,14937052 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05728035 0,14920136 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05728035 0,14903258 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05728035 0,14886418 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05728035 0,14869616 ! adult feeding behavior GO:0008343 6 6 0,000 0,05728035 0,14852852 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05728035 0,14836126 ! blastocyst growth GO:0001832 15 6 0,000 0,05728035 0,14819437 ! pigment granule transport GO:0051904 12 6 0,000 0,05728035 0,14802786 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05728035 0,14786173 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05728035 0,14769596 ! catecholamine transport GO:0051937 7 6 0,000 0,05728035 0,14753057 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05728035 0,14736555 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05728035 0,14720089 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,05728035 0,1470366 ! protein prenylation GO:0018342 10 6 0,000 0,05728035 0,14687268 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05728035 0,14670913 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,05728035 0,14654594 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05728035 0,14638311 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05728035 0,14622064 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05728035 0,14605853 ! response to calcium ion GO:0051592 58 40 1,000 0,05823938 0,14833951 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,05823938 0,14817542 ! peptide metabolic process GO:0006518 56 40 1,000 0,05823938 0,14801169 ! double-strand break repair GO:0006302 67 40 1,000 0,05823938 0,14784832 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,05823938 0,14768531 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,05823938 0,14752266 ! protein amino acid lipidation GO:0006497 62 41 1,000 0,06084323 0,15394877 ! endosome transport GO:0016197 71 41 1,000 0,06084323 0,1537796 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,06084323 0,15361079 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,06084323 0,15344236 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,06084323 0,1532743 ! biopolymer methylation GO:0043414 62 41 1,000 0,06084323 0,1531066 ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,0630781 0,15855697 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,06348632 0,15940887 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,06348632 0,15923504 ! regulation of cell shape GO:0008360 78 42 1,000 0,06348632 0,15906158 ! positive regulation of binding GO:0051099 59 43 1,000 0,06616763 0,16559907 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,06616763 0,16541908 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,06616763 0,16523947 ! vesicle organization GO:0016050 79 43 1,000 0,06616763 0,16506025 ! methylation GO:0032259 64 43 1,000 0,06616763 0,16488142 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06650471 0,16554204 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06650471 0,16536308 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06650471 0,1651845 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,06650471 0,1650063 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06650471 0,1648285 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06650471 0,16465107 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06650471 0,16447403 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06650471 0,16429736 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,06650471 0,16412108 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06650471 0,16394517 ! reproductive behavior GO:0019098 12 7 0,000 0,06650471 0,16376964 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06650471 0,16359449 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06650471 0,16341971 ! oligopeptide transport GO:0006857 11 7 0,000 0,06650471 0,1632453 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06650471 0,16307126 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06650471 0,1628976 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,06650471 0,1627243 ! RNA methylation GO:0001510 11 7 0,000 0,06650471 0,16255138 ! pericardium development GO:0060039 8 7 0,000 0,06650471 0,16237882 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06650471 0,16220662 ! fibril organization GO:0043206 13 7 0,000 0,06650471 0,16203479 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,06650471 0,16186333 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06650471 0,16169222 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06650471 0,16152148 ! lipoprotein transport GO:0042953 9 7 0,000 0,06650471 0,1613511 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,06650471 0,16118108 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06650471 0,16101142 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06650471 0,16084211 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06650471 0,16067316 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,06650471 0,16050456 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06650471 0,16033631 ! chemosensory behavior GO:0007635 9 7 0,000 0,06650471 0,16016842 ! microtubule bundle formation GO:0001578 8 7 0,000 0,06650471 0,16000088 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,06650471 0,15983369 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06650471 0,15966685 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06650471 0,15950036 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06650471 0,15933421 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06650471 0,15916841 ! reflex GO:0060004 12 7 0,000 0,06650471 0,15900296 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06650471 0,15883784 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06650471 0,15867308 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06650471 0,15850865 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,06650471 0,15834456 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06650471 0,15818081 ! spinal cord patterning GO:0021511 7 7 0,000 0,06650471 0,1580174 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,06650471 0,15785433 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06650471 0,15769159 ! adrenal gland development GO:0030325 17 7 0,000 0,06650471 0,15752919 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06650471 0,15736712 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06650471 0,15720539 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06650471 0,15704399 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06650471 0,15688292 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06650471 0,15672218 ! endosome organization GO:0007032 10 7 0,000 0,06650471 0,15656176 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06650471 0,15640168 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,06650471 0,15624192 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06650471 0,15608249 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06650471 0,15592339 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06650471 0,15576461 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06650471 0,15560615 ! galactose metabolic process GO:0006012 10 7 0,000 0,06650471 0,15544801 ! vesicle fusion GO:0006906 15 7 0,000 0,06650471 0,1552902 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06650471 0,1551327 GO:0045851|pH reduction, ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06650471 0,15497553 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06650471 0,15481867 ! retinol metabolic process GO:0042572 9 7 0,000 0,06650471 0,15466213 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,06650471 0,1545059 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06650471 0,15434999 ! rRNA modification GO:0000154 12 7 0,000 0,06650471 0,1541944 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06650471 0,15403912 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06650471 0,15388415 ! intermediate filament organization GO:0045109 11 7 0,000 0,06650471 0,15372949 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06650471 0,15357514 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06650471 0,15342111 ! fibrinolysis GO:0042730 9 7 0,000 0,06650471 0,15326738 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,06650471 0,15311396 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06650471 0,15296084 ! response to tropane GO:0014073 13 7 0,000 0,06650471 0,15280804 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,06650471 0,15265553 ! melanosome localization GO:0032400 10 7 0,000 0,06650471 0,15250333 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06650471 0,15235144 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06650471 0,15219985 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06650471 0,15204855 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06650471 0,15189756 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06650471 0,15174687 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06650471 0,15159648 ! mast cell activation GO:0045576 9 7 0,000 0,06650471 0,15144638 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06650471 0,15129658 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,06650471 0,15114708 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06650471 0,15099787 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06650471 0,15084896 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,06650471 0,15070034 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06650471 0,15055201 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06650471 0,15040398 GO:0002714|positive regulation of B cell mediated immunity, ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06650471 0,15025623 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06650471 0,15010878 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06650471 0,14996161 ! neuroblast proliferation GO:0007405 13 7 0,000 0,06650471 0,14981473 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06650471 0,14966815 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06650471 0,14952184 ! diuresis GO:0030146 12 7 0,000 0,06650471 0,14937582 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06650471 0,14923009 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06650471 0,14908464 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06650471 0,14893948 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,06650471 0,1487946 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06650471 0,14864999 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06650471 0,14850567 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06650471 0,14836163 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,06650471 0,14821787 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06650471 0,14807439 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06650471 0,14793118 ! lymph node development GO:0048535 9 7 0,000 0,06650471 0,14778826 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06650471 0,1476456 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06650471 0,14750323 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06650471 0,14736112 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06650471 0,14721929 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06650471 0,14707773 ! ATP catabolic process GO:0006200 10 7 0,000 0,06650471 0,14693645 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06650471 0,14679544 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,06650471 0,14665469 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06650471 0,14651422 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06650471 0,14637401 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06650471 0,14623408 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06650471 0,14609441 ! muscle adaptation GO:0043500 12 7 0,000 0,06650471 0,145955 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06650471 0,14581587 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,06650471 0,14567699 ! retina homeostasis GO:0001895 9 7 0,000 0,06650471 0,14553839 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06650471 0,14540004 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,06650471 0,14526196 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06650471 0,14512414 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06650471 0,14498658 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06650471 0,14484928 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06650471 0,14471225 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06650471 0,14457547 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,068026 0,14774297 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,06888618 0,14947002 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,06888618 0,14932914 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,06888618 0,14918853 ! lipoprotein biosynthetic process GO:0042158 67 45 1,000 0,071641 0,15500874 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,07443111 0,16089432 ! regulation of translation GO:0006417 151 100 2,000 0,07488893 0,16173197 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,07563935 0,16319934 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,07563935 0,16304639 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,07563935 0,16289372 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,07563935 0,16274135 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,07563935 0,16258925 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,07563935 0,16243744 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,07563935 0,16228591 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,07563935 0,16213467 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,07563935 0,1619837 ! phosphate transport GO:0006817 10 8 0,000 0,07563935 0,16183302 ! N-glycan processing GO:0006491 12 8 0,000 0,07563935 0,16168262 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,07563935 0,1615325 ! UTP metabolic process GO:0046051 8 8 0,000 0,07563935 0,16138265 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,07563935 0,16123308 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,07563935 0,16108379 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,07563935 0,16093478 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,07563935 0,16078604 ! succinate metabolic process GO:0006105 14 8 0,000 0,07563935 0,16063758 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,07563935 0,16048939 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,07563935 0,16034147 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,07563935 0,16019383 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,07563935 0,16004646 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,07563935 0,15989935 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,07563935 0,15975252 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,07563935 0,15960596 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,07563935 0,15945967 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,07563935 0,15931364 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,07563935 0,15916788 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,07563935 0,15902239 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,07563935 0,15887717 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,07563935 0,15873221 ! astrocyte differentiation GO:0048708 16 8 0,000 0,07563935 0,15858751 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,07563935 0,15844308 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,07563935 0,15829891 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,07563935 0,158155 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,07563935 0,15801135 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,07563935 0,15786797 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,07563935 0,15772484 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,07563935 0,15758197 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,07563935 0,15743936 ! macrophage activation GO:0042116 12 8 0,000 0,07563935 0,15729701 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,07563935 0,15715492 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,07563935 0,15701308 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,07563935 0,1568715 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,07563935 0,15673018 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,07563935 0,15658911 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,07563935 0,15644829 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,07563935 0,15630772 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,07563935 0,15616741 ! ruffle organization GO:0031529 11 8 0,000 0,07563935 0,15602735 ! osteoblast development GO:0002076 13 8 0,000 0,07563935 0,15588754 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,07563935 0,15574798 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,07563935 0,15560867 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,07563935 0,15546961 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,07563935 0,1553308 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,07563935 0,15519224 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,07563935 0,15505392 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,07563935 0,15491585 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,07563935 0,15477802 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,07563935 0,15464044 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,07563935 0,15450311 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,07563935 0,15436601 ! oligodendrocyte development GO:0014003 8 8 0,000 0,07563935 0,15422916 ! segment specification GO:0007379 10 8 0,000 0,07563935 0,15409256 ! cellular extravasation GO:0045123 11 8 0,000 0,07563935 0,15395619 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,07563935 0,15382007 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,07563935 0,15368419 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,07563935 0,15354854 ! snRNA metabolic process GO:0016073 10 8 0,000 0,07563935 0,15341314 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,07563935 0,15327797 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,07563935 0,15314304 ! nucleosome disassembly GO:0006337 12 8 0,000 0,07563935 0,15300835 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,07563935 0,1528739 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,07563935 0,15273968 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,07563935 0,1526057 ! icosanoid secretion GO:0032309 12 8 0,000 0,07563935 0,15247195 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,07563935 0,15233844 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,07563935 0,15220516 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,07563935 0,15207211 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,07563935 0,1519393 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,07563935 0,15180672 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,07563935 0,15167437 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,07563935 0,15154225 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,07563935 0,15141036 ! sterol catabolic process GO:0016127 9 8 0,000 0,07563935 0,15127869 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,07563935 0,15114726 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,07563935 0,15101606 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,07563935 0,15088508 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,07563935 0,15075433 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,07563935 0,15062381 ! prophase GO:0051324 11 8 0,000 0,07563935 0,15049351 ! S phase GO:0051320 8 8 0,000 0,07563935 0,15036344 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,07563935 0,15023359 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,07563935 0,15010397 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,07563935 0,14997457 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,07563935 0,14984539 ! hormone catabolic process GO:0042447 13 8 0,000 0,07563935 0,14971644 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,07563935 0,1495877 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,07563935 0,14945919 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,07563935 0,1493309 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,07563935 0,14920283 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,07563935 0,14907498 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,07563935 0,14894734 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,07563935 0,14881993 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,07563935 0,14869273 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,07563935 0,14856575 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,07563935 0,14843899 ! lamellipodium assembly GO:0030032 9 8 0,000 0,07563935 0,14831244 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,07563935 0,14818611 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,07563935 0,14806 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,07563935 0,1479341 ! chloride transport GO:0006821 67 48 1,000 0,08011349 0,15655142 ! heart morphogenesis GO:0003007 65 48 1,000 0,08011349 0,15641853 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,08011349 0,15628586 GO:0019724|B cell mediated immunity, ! nuclear export GO:0051168 69 48 1,000 0,08011349 0,15615341 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,08011349 0,15602119 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,08011349 0,15588919 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,08300391 0,16137699 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,08300391 0,1612407 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,08468511 0,16436772 ! telencephalon cell migration GO:0022029 16 9 0,000 0,08468511 0,16422913 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,08468511 0,16409078 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,08468511 0,16395265 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,08468511 0,16381476 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,08468511 0,1636771 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,08468511 0,16353968 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,08468511 0,16340248 ! GTP metabolic process GO:0046039 9 9 0,000 0,08468511 0,16326551 ! elastic fiber assembly GO:0048251 13 9 0,000 0,08468511 0,16312877 ! social behavior GO:0035176 14 9 0,000 0,08468511 0,16299226 ! artery development GO:0060840 19 9 0,000 0,08468511 0,16285598 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,08468511 0,16271993 ! response to pain GO:0048265 16 9 0,000 0,08468511 0,1625841 ! protein complex disassembly GO:0043241 17 9 0,000 0,08468511 0,1624485 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,08468511 0,16231313 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,08468511 0,16217798 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,08468511 0,16204306 ! lung alveolus development GO:0048286 17 9 0,000 0,08468511 0,16190836 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,08468511 0,16177388 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,08468511 0,16163963 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,08468511 0,1615056 ! ventral spinal cord development GO:0021517 11 9 0,000 0,08468511 0,16137179 ! protein targeting to ER GO:0045047 19 9 0,000 0,08468511 0,16123821 ! endoderm development GO:0007492 12 9 0,000 0,08468511 0,16110484 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,08468511 0,1609717 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,08468511 0,16083877 ! arginine catabolic process GO:0006527 10 9 0,000 0,08468511 0,16070607 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,08468511 0,16057358 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,08468511 0,16044131 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,08468511 0,16030926 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,08468511 0,16017743 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,08468511 0,16004581 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,08468511 0,15991441 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,08468511 0,15978323 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,08468511 0,15965226 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,08468511 0,1595215 ! mannose metabolic process GO:0006013 9 9 0,000 0,08468511 0,15939096 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,08468511 0,15926063 ! epithelial cell development GO:0002064 10 9 0,000 0,08468511 0,15913052 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,08468511 0,15900062 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,08468511 0,15887092 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,08468511 0,15874145 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,08468511 0,15861218 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,08468511 0,15848312 ! motor axon guidance GO:0008045 14 9 0,000 0,08468511 0,15835427 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,08468511 0,15822563 ! blastoderm segmentation GO:0007350 11 9 0,000 0,08468511 0,1580972 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,08468511 0,15796898 ! DNA ligation GO:0006266 14 9 0,000 0,08468511 0,15784097 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,08468511 0,15771316 ! response to amine stimulus GO:0014075 13 9 0,000 0,08468511 0,15758556 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,08468511 0,15745817 ! erythrocyte development GO:0048821 11 9 0,000 0,08468511 0,15733098 ! renal water homeostasis GO:0003091 14 9 0,000 0,08468511 0,157204 ! postreplication repair GO:0006301 11 9 0,000 0,08468511 0,15707722 ! mRNA cleavage GO:0006379 13 9 0,000 0,08468511 0,15695065 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,08468511 0,15682428 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,08468511 0,15669811 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,08468511 0,15657215 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,08468511 0,15644639 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,08468511 0,15632083 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,08468511 0,15619547 ! acid secretion GO:0046717 14 9 0,000 0,08468511 0,15607032 ! musculoskeletal movement GO:0050881 11 9 0,000 0,08468511 0,15594536 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,08468511 0,1558206 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,08468511 0,15569605 ! purine base metabolic process GO:0006144 18 9 0,000 0,08468511 0,15557169 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,08468511 0,15544753 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,08468511 0,15532357 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,08468511 0,1551998 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,08468511 0,15507624 ! detection of calcium ion GO:0005513 13 9 0,000 0,08468511 0,15495287 ! blastocyst formation GO:0001825 12 9 0,000 0,08468511 0,15482969 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,08468511 0,15470671 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,08468511 0,15458393 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,08468511 0,15446134 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,08468511 0,15433895 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,08468511 0,15421675 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,08468511 0,15409474 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,08468511 0,15397293 ! prepulse inhibition GO:0060134 14 9 0,000 0,08468511 0,15385131 ! embryonic placenta development GO:0001892 12 9 0,000 0,08468511 0,15372988 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,08468511 0,15360864 ! insulin secretion GO:0030073 17 9 0,000 0,08468511 0,15348759 ! establishment of cell polarity GO:0030010 12 9 0,000 0,08468511 0,15336674 ! regulation of synapse organization GO:0050807 12 9 0,000 0,08468511 0,15324607 ! localization within membrane GO:0051668 15 9 0,000 0,08468511 0,15312559 ! membrane fusion GO:0006944 80 50 1,000 0,08592594 0,15524717 ! proton transport GO:0015992 75 50 1,000 0,08592594 0,15512532 ! hydrogen transport GO:0006818 77 51 1,000 0,08887869 0,16033019 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,08887869 0,16020454 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,08887869 0,16007908 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,09364287 0,16852785 ! neuron fate specification GO:0048665 11 10 0,000 0,09364287 0,16839608 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,09364287 0,16826452 ! thyroid gland development GO:0030878 19 10 0,000 0,09364287 0,16813317 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,09364287 0,16800202 ! synapsis GO:0007129 13 10 0,000 0,09364287 0,16787108 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,09364287 0,16774033 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,09364287 0,1676098 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,09364287 0,16747946 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,09364287 0,16734933 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,09364287 0,1672194 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,09364287 0,16708967 ! phospholipid efflux GO:0033700 16 10 0,000 0,09364287 0,16696015 ! hippocampus development GO:0021766 19 10 0,000 0,09364287 0,16683082 ! blood vessel remodeling GO:0001974 21 10 0,000 0,09364287 0,16670169 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,09364287 0,16657277 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,09364287 0,16644404 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,09364287 0,16631551 ! pathogenesis GO:0009405 13 10 0,000 0,09364287 0,16618718 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,09364287 0,16605905 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,09364287 0,16593112 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,09364287 0,16580338 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,09364287 0,16567584 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,09364287 0,16554849 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,09364287 0,16542134 ! melanocyte differentiation GO:0030318 15 10 0,000 0,09364287 0,16529439 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,09364287 0,16516763 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,09364287 0,16504106 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,09364287 0,16491469 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,09364287 0,16478852 ! forebrain cell migration GO:0021885 17 10 0,000 0,09364287 0,16466253 ! lipid digestion GO:0044241 15 10 0,000 0,09364287 0,16453674 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,09364287 0,16441114 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,09364287 0,16428573 ! UV protection GO:0009650 14 10 0,000 0,09364287 0,16416051 ! entry into host cell GO:0030260 20 10 0,000 0,09364287 0,16403548 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,09364287 0,16391065 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,09364287 0,163786 ! regulation of bone resorption GO:0045124 24 10 0,000 0,09364287 0,16366154 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,09364287 0,16353727 ! regulation of organ growth GO:0046620 11 10 0,000 0,09364287 0,16341319 ! response to dsRNA GO:0043331 18 10 0,000 0,09364287 0,1632893 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,09364287 0,1631656 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,09364287 0,16304208 ! embryonic axis specification GO:0000578 12 10 0,000 0,09364287 0,16291875 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,09364287 0,16279561 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,09364287 0,16267265 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,09364287 0,16254988 ! cranial nerve development GO:0021545 12 10 0,000 0,09364287 0,16242729 ! fucose catabolic process GO:0019317 16 10 0,000 0,09364287 0,16230489 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,09364287 0,16218267 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,09364287 0,16206064 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,09364287 0,16193879 ! zymogen activation GO:0031638 14 10 0,000 0,09364287 0,16181712 ! salivary gland development GO:0007431 22 10 0,000 0,09364287 0,16169564 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,09364287 0,16157434 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,09364287 0,16145322 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,09364287 0,16133228 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,09364287 0,16121152 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,09364287 0,16109094 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,09364287 0,16097055 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,09364287 0,16085033 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,09364287 0,16073029 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,09364287 0,16061043 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,09364287 0,16049075 ! detection of bacterium GO:0016045 10 10 0,000 0,09364287 0,16037125 ! embryonic gut development GO:0048566 11 10 0,000 0,09364287 0,16025193 ! activation of innate immune response GO:0002218 10 10 0,000 0,09364287 0,16013278 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,09364287 0,16001381 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,09364287 0,15989502 ! developmental induction GO:0031128 13 10 0,000 0,09364287 0,1597764 GO:0045168|cell-cell signaling involved in cell fate specification, ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,09364287 0,15965796 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,09364287 0,1595397 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,09487291 0,16151568 ! kidney development GO:0001822 90 53 1,000 0,09487291 0,16139622 ! regulation of mitosis GO:0007088 84 54 1,000 0,09791267 0,1664443 GO:0051783|regulation of nuclear division, ! detection of external stimulus GO:0009581 66 54 1,000 0,09791267 0,16632137 ! rRNA transcription GO:0009303 17 11 0,000 0,10251346 0,17400809 ! respiratory burst GO:0045730 14 11 0,000 0,10251346 0,17387977 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,10251346 0,17375163 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,10251346 0,17362368 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,10251346 0,17349593 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,10251346 0,17336835 ! RNA polyadenylation GO:0043631 19 11 0,000 0,10251346 0,17324097 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,10251346 0,17311378 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,10251346 0,17298677 ! T cell proliferation GO:0042098 20 11 0,000 0,10251346 0,17285994 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,10251346 0,17273331 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,10251346 0,17260685 ! bone resorption GO:0045453 16 11 0,000 0,10251346 0,17248059 ! regulated secretory pathway GO:0045055 14 11 0,000 0,10251346 0,1723545 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,10251346 0,17222861 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,10251346 0,17210289 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,10251346 0,17197736 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,10251346 0,17185201 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,10251346 0,17172685 ! syncytium formation GO:0006949 15 11 0,000 0,10251346 0,17160187 ! plasma membrane organization GO:0007009 18 11 0,000 0,10251346 0,17147706 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,10251346 0,17135244 ! mitotic spindle organization GO:0007052 15 11 0,000 0,10251346 0,171228 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,10251346 0,17110375 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,10251346 0,17097967 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,10251346 0,17085577 ! adult heart development GO:0007512 11 11 0,000 0,10251346 0,17073205 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,10251346 0,17060851 ! temperature homeostasis GO:0001659 16 11 0,000 0,10251346 0,17048515 ! L-glutamate transport GO:0015813 16 11 0,000 0,10251346 0,17036197 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,10251346 0,17023896 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,10251346 0,17011613 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,10251346 0,16999348 ! stem cell development GO:0048864 29 11 0,000 0,10251346 0,16987101 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,10251346 0,16974871 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,10251346 0,16962659 ! vasoconstriction GO:0042310 15 11 0,000 0,10251346 0,16950465 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,10251346 0,16938288 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,10251346 0,16926128 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,10251346 0,16913986 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,10251346 0,16901861 ! ribosome assembly GO:0042255 13 11 0,000 0,10251346 0,16889754 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,10251346 0,16877664 GO:0006809|nitric oxide biosynthetic process, ! chromatin silencing GO:0006342 19 11 0,000 0,10251346 0,16865591 ! nucleosome positioning GO:0016584 13 11 0,000 0,10251346 0,16853536 ! regulation of isotype switching GO:0045191 19 11 0,000 0,10251346 0,16841497 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,10251346 0,16829476 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,10251346 0,16817472 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,10251346 0,16805486 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,10251346 0,16793516 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,10251346 0,16781563 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,10251346 0,16769627 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,10251346 0,16757709 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,10251346 0,16745807 ! male genitalia development GO:0030539 13 11 0,000 0,10251346 0,16733922 ! cholesterol efflux GO:0033344 19 11 0,000 0,10251346 0,16722054 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,10251346 0,16710203 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,10251346 0,16698368 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,10251346 0,16686551 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,10251346 0,1667475 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,10251346 0,16662966 ! defense response to fungus GO:0050832 12 11 0,000 0,10251346 0,16651198 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,10251346 0,16639447 ! lysogeny GO:0030069 18 11 0,000 0,10251346 0,16627712 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,10251346 0,16615995 ! acrosome reaction GO:0007340 13 11 0,000 0,10251346 0,16604293 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,10251346 0,16592608 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,10407333 0,16833239 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,10719261 0,17325581 GO:0048609|reproductive process in a multicellular organism, ! secondary metabolic process GO:0019748 84 57 1,000 0,10719261 0,17313414 ! developmental maturation GO:0021700 75 57 1,000 0,10719261 0,17301264 ! gonad development GO:0008406 79 57 1,000 0,10719261 0,17289131 ! viral reproductive process GO:0022415 87 58 1,000 0,1103368 0,17783788 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,1103368 0,17771334 ! lactation GO:0007595 20 12 0,000 0,11129774 0,17913563 ! reproductive cellular process GO:0048610 14 12 0,000 0,11129774 0,17901036 ! tRNA modification GO:0006400 14 12 0,000 0,11129774 0,17888526 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,11129774 0,17876034 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,11129774 0,1786356 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,11129774 0,17851103 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,11129774 0,17838663 ! non-recombinational repair GO:0000726 19 12 0,000 0,11129774 0,1782624 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,11129774 0,17813835 ! peroxisomal transport GO:0043574 21 12 0,000 0,11129774 0,17801447 ! cartilage condensation GO:0001502 18 12 0,000 0,11129774 0,17789077 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,11129774 0,17776723 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,11129774 0,17764387 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,11129774 0,17752067 ! heart looping GO:0001947 15 12 0,000 0,11129774 0,17739765 ! palate development GO:0060021 15 12 0,000 0,11129774 0,1772748 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,11129774 0,17715212 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,11129774 0,17702961 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,11129774 0,17690726 ! arginine metabolic process GO:0006525 13 12 0,000 0,11129774 0,17678509 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,11129774 0,17666309 ! methionine metabolic process GO:0006555 13 12 0,000 0,11129774 0,17654125 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,11129774 0,17641958 ! Golgi organization GO:0007030 18 12 0,000 0,11129774 0,17629808 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,11129774 0,17617675 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,11129774 0,17605558 ! monoamine transport GO:0015844 13 12 0,000 0,11129774 0,17593458 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,11129774 0,17581374 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,11129774 0,17569308 ! L-amino acid transport GO:0015807 20 12 0,000 0,11129774 0,17557257 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,11129774 0,17545224 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,11129774 0,17533206 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,11129774 0,17521205 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,11129774 0,17509221 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,11129774 0,17497253 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,11129774 0,17485301 ! cerebellum development GO:0021549 13 12 0,000 0,11129774 0,17473366 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,11129774 0,17461447 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,11129774 0,17449544 ! histone methylation GO:0016571 15 12 0,000 0,11129774 0,17437658 ! autonomic nervous system development GO:0048483 23 12 0,000 0,11129774 0,17425787 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,11129774 0,17413933 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,11129774 0,17402095 ! regulation of epidermis development GO:0045682 17 12 0,000 0,11129774 0,17390273 ! intestinal absorption GO:0050892 19 12 0,000 0,11129774 0,17378467 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,11129774 0,17366677 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,11129774 0,17354903 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,11129774 0,17343144 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,11129774 0,17331402 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,11129774 0,17319676 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,11129774 0,17307966 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,11129774 0,17296271 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,11129774 0,17284592 ! response to cold GO:0009409 14 12 0,000 0,11129774 0,17272929 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,11350513 0,17603627 ! activation of MAPK activity GO:0000187 84 59 1,000 0,11350513 0,17591765 ! lung development GO:0030324 94 59 1,000 0,11350513 0,17579918 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,11669681 0,18062091 ! meiosis GO:0007126 96 61 1,000 0,11991111 0,18547111 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 1,000 0,11991111 0,18534647 ! urogenital system development GO:0001655 101 61 1,000 0,11991111 0,18522199 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,11991111 0,18509768 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,11999655 0,18510534 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,11999655 0,18498127 ! cGMP metabolic process GO:0046068 16 13 0,000 0,11999655 0,18485737 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,11999655 0,18473364 ! water transport GO:0006833 17 13 0,000 0,11999655 0,18461007 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,11999655 0,18448667 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,11999655 0,18436343 ! lipid localization GO:0010876 24 13 0,000 0,11999655 0,18424036 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,11999655 0,18411745 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,11999655 0,18399471 ! organelle fusion GO:0048284 28 13 0,000 0,11999655 0,18387212 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,11999655 0,18374971 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,11999655 0,18362745 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,11999655 0,18350536 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,11999655 0,18338343 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,11999655 0,18326166 ! response to hexose stimulus GO:0009746 19 13 0,000 0,11999655 0,18314005 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,11999655 0,18301861 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,11999655 0,18289732 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,11999655 0,1827762 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,11999655 0,18265523 ! NAD metabolic process GO:0019674 21 13 0,000 0,11999655 0,18253443 ! exocrine system development GO:0035272 27 13 0,000 0,11999655 0,18241379 ! bone mineralization GO:0030282 15 13 0,000 0,11999655 0,1822933 ! regulation of exocytosis GO:0017157 17 13 0,000 0,11999655 0,18217298 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,11999655 0,18205281 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,11999655 0,1819328 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,11999655 0,18181295 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,11999655 0,18169326 ! genitalia development GO:0048806 15 13 0,000 0,11999655 0,18157372 ! tissue regeneration GO:0042246 21 13 0,000 0,11999655 0,18145434 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,11999655 0,18133512 ! cofactor transport GO:0051181 19 13 0,000 0,11999655 0,18121606 ! NADP metabolic process GO:0006739 18 13 0,000 0,11999655 0,18109715 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,11999655 0,1809784 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,11999655 0,1808598 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,11999655 0,18074136 ! gas transport GO:0015669 18 13 0,000 0,11999655 0,18062308 ! regulation of RNA stability GO:0043487 28 13 0,000 0,11999655 0,18050494 ! heme biosynthetic process GO:0006783 20 13 0,000 0,11999655 0,18038697 ! regulation of axon extension GO:0030516 23 13 0,000 0,11999655 0,18026914 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,11999655 0,18015147 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,11999655 0,18003396 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,11999655 0,1799166 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,11999655 0,17979939 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,11999655 0,17968233 ! respiratory tube development GO:0030323 99 62 1,000 0,12314727 0,18428024 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,12314727 0,18416042 ! meiotic cell cycle GO:0051321 97 62 1,000 0,12314727 0,18404076 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,12640458 0,18878606 ! viral reproduction GO:0016032 92 63 1,000 0,12640458 0,18866356 ! superoxide anion generation GO:0042554 18 14 0,000 0,1286107 0,19183178 ! neuron maturation GO:0042551 21 14 0,000 0,1286107 0,19170746 ! regulation of S phase GO:0033261 18 14 0,000 0,1286107 0,19158329 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,1286107 0,19145929 ! myotube differentiation GO:0014902 21 14 0,000 0,1286107 0,19133545 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,1286107 0,19121177 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,1286107 0,19108825 ! inositol metabolic process GO:0006020 20 14 0,000 0,1286107 0,19096488 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,1286107 0,19084168 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,1286107 0,19071864 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,1286107 0,19059575 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,1286107 0,19047302 ! gene silencing by RNA GO:0031047 20 14 0,000 0,1286107 0,19035045 ! response to cAMP GO:0051591 19 14 0,000 0,1286107 0,19022804 ! limbic system development GO:0021761 25 14 0,000 0,1286107 0,19010579 ! startle response GO:0001964 21 14 0,000 0,1286107 0,18998369 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,1286107 0,18986175 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,1286107 0,18973996 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,1286107 0,18961834 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,1286107 0,18949686 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,1286107 0,18937555 ! glycine metabolic process GO:0006544 22 14 0,000 0,1286107 0,18925439 ! pituitary gland development GO:0021983 23 14 0,000 0,1286107 0,18913338 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,1286107 0,18901253 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,1286107 0,18889183 ! regulation of heart rate GO:0002027 23 14 0,000 0,1286107 0,18877129 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,1286107 0,1886509 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,1286107 0,18853066 ! embryo implantation GO:0007566 27 14 0,000 0,1286107 0,18841058 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,1286107 0,18829065 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! axon cargo transport GO:0008088 27 14 0,000 0,1286107 0,18817087 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,1286107 0,18805124 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,1286107 0,18793177 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,1286107 0,18781245 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,1286107 0,18769328 ! mRNA splice site selection GO:0006376 26 14 0,000 0,1286107 0,18757426 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,1286107 0,18745539 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,1286107 0,18733667 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,1286107 0,1872181 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,1286107 0,18709969 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,1286107 0,18698142 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,1286107 0,1868633 ! muscle maintenance GO:0046716 19 14 0,000 0,1286107 0,18674533 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,1286107 0,18662751 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,1286107 0,18650984 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,1286107 0,18639232 ! cell killing GO:0001906 20 14 0,000 0,1286107 0,18627494 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,1286107 0,18615771 ! cilium assembly GO:0042384 20 14 0,000 0,1286107 0,18604063 ! peptide hormone secretion GO:0030072 23 14 0,000 0,1286107 0,1859237 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,12968232 0,1873551 ! respiratory system development GO:0060541 100 64 1,000 0,12968232 0,18723749 ! adaptive immune response GO:0002250 94 64 1,000 0,12968232 0,18712003 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 1,000 0,13297977 0,19175766 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,13297977 0,19163751 ! antigen processing and presentation GO:0019882 96 66 1,000 0,13629625 0,19629391 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,13629625 0,19617107 ! regulation of immune effector process GO:0002697 101 66 1,000 0,13629625 0,19604839 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,13714101 0,19714021 ! positive regulation of cell size GO:0045793 20 15 0,000 0,13714101 0,19701707 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,13714101 0,19689409 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,13714101 0,19677126 ! skin development GO:0043588 25 15 0,000 0,13714101 0,19664859 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,13714101 0,19652606 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,13714101 0,19640369 ! lipid phosphorylation GO:0046834 23 15 0,000 0,13714101 0,19628148 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,13714101 0,19615941 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,13714101 0,1960375 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,13714101 0,19591573 ! bile acid metabolic process GO:0008206 22 15 0,000 0,13714101 0,19579412 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,13714101 0,19567266 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,13714101 0,19555135 ! adult walking behavior GO:0007628 25 15 0,000 0,13714101 0,19543019 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,13714101 0,19530918 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,13714101 0,19518832 ! myoblast differentiation GO:0045445 27 15 0,000 0,13714101 0,19506761 ! centrosome cycle GO:0007098 16 15 0,000 0,13714101 0,19494705 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,13714101 0,19482664 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,13714101 0,19470638 ! cerebral cortex development GO:0021987 29 15 0,000 0,13714101 0,19458626 ! response to osmotic stress GO:0006970 22 15 0,000 0,13714101 0,1944663 ! vesicle coating GO:0006901 25 15 0,000 0,13714101 0,19434648 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,13714101 0,19422681 ! DNA integration GO:0015074 22 15 0,000 0,13714101 0,19410728 ! peptide secretion GO:0002790 27 15 0,000 0,13714101 0,1939879 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,13714101 0,19386867 ! regulation of vasodilation GO:0042312 24 15 0,000 0,13714101 0,19374959 ! neuron recognition GO:0008038 22 15 0,000 0,13714101 0,19363065 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,13714101 0,19351186 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,13714101 0,19339321 ! biomineral formation GO:0031214 18 15 0,000 0,13714101 0,19327471 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,13714101 0,19315636 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,13714101 0,19303815 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,13714101 0,19292008 ! dopamine metabolic process GO:0042417 30 15 0,000 0,13714101 0,19280216 ! organic cation transport GO:0015695 19 15 0,000 0,13714101 0,19268438 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,13714101 0,19256675 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,13714101 0,19244926 ! peptide hormone processing GO:0016486 19 15 0,000 0,13714101 0,19233191 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,13714101 0,19221471 ! acute inflammatory response GO:0002526 92 68 1,000 0,14298358 0,2002815 ! learning or memory GO:0007611 123 68 1,000 0,14298358 0,2001596 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,14298358 0,20003785 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,14298358 0,19991625 ! inorganic anion transport GO:0015698 93 68 1,000 0,14298358 0,19979479 ! protein secretion GO:0009306 27 16 0,000 0,14558831 0,20331093 ! hormone secretion GO:0046879 25 16 0,000 0,14558831 0,20318757 ! bone remodeling GO:0046849 24 16 0,000 0,14558831 0,20306435 ! endothelial cell migration GO:0043542 22 16 0,000 0,14558831 0,20294128 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,14558831 0,20281836 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,14558831 0,20269559 ! glial cell development GO:0021782 24 16 0,000 0,14558831 0,20257296 ! patterning of blood vessels GO:0001569 24 16 0,000 0,14558831 0,20245049 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,14558831 0,20232816 GO:0042744|hydrogen peroxide catabolic process, ! protein polyubiquitination GO:0000209 26 16 0,000 0,14558831 0,20220598 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,14558831 0,20208395 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,14558831 0,20196207 ! fructose metabolic process GO:0006000 20 16 0,000 0,14558831 0,20184033 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,14558831 0,20171874 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,14558831 0,2015973 ! negative regulation of immune response GO:0050777 28 16 0,000 0,14558831 0,201476 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,14558831 0,20135485 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,14558831 0,20123384 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,14558831 0,20111298 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,14558831 0,20099226 ! diencephalon development GO:0021536 25 16 0,000 0,14558831 0,20087169 ! neural crest cell migration GO:0001755 24 16 0,000 0,14558831 0,20075126 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,14558831 0,20063098 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,14558831 0,20051084 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,14558831 0,20039085 ! steroid catabolic process GO:0006706 22 16 0,000 0,14558831 0,200271 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,14558831 0,20015129 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,14558831 0,20003173 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,14558831 0,1999123 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,14558831 0,19979302 ! sperm-egg recognition GO:0035036 16 16 0,000 0,14558831 0,19967389 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,14558831 0,19955489 ! nerve development GO:0021675 18 16 0,000 0,14558831 0,19943604 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,14558831 0,19931733 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,14635309 0,20024516 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,14973898 0,20475603 ! muscle cell differentiation GO:0042692 104 71 1,000 0,15314059 0,20928305 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,15314059 0,20915877 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,15314059 0,20903464 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,15395338 0,21001944 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,15395338 0,20989495 ! negative regulation of defense response GO:0031348 19 17 0,000 0,15395338 0,20977061 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,15395338 0,20964641 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,15395338 0,20952236 ! glycerol metabolic process GO:0006071 20 17 0,000 0,15395338 0,20939845 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,15395338 0,20927469 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,15395338 0,20915108 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,15395338 0,20902762 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,15395338 0,2089043 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,15395338 0,20878112 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,15395338 0,20865809 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,15395338 0,20853521 ! memory GO:0007613 25 17 0,000 0,15395338 0,20841247 ! keratinization GO:0031424 17 17 0,000 0,15395338 0,20828987 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,15395338 0,20816742 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,15395338 0,20804511 ! retinoid metabolic process GO:0001523 22 17 0,000 0,15395338 0,20792295 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,15395338 0,20780093 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,15395338 0,20767905 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,15395338 0,20755732 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,15395338 0,20743572 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,15395338 0,20731427 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,15395338 0,20719297 ! membrane budding GO:0006900 29 17 0,000 0,15395338 0,2070718 ! heme metabolic process GO:0042168 27 17 0,000 0,15395338 0,20695078 ! neuromuscular junction development GO:0007528 23 17 0,000 0,15395338 0,2068299 ! body fluid secretion GO:0007589 27 17 0,000 0,15395338 0,20670915 ! stem cell differentiation GO:0048863 36 17 0,000 0,15395338 0,20658855 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,15395338 0,20646809 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,15395338 0,20634777 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,15395338 0,2062276 ! sensory perception of pain GO:0019233 23 17 0,000 0,15395338 0,20610756 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,15395338 0,20598766 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,15395338 0,2058679 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,15395338 0,20574828 ! synaptogenesis GO:0007416 24 17 0,000 0,15395338 0,20562879 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,15395338 0,20550945 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,15395338 0,20539024 ! cell-cell junction organization GO:0045216 25 17 0,000 0,15395338 0,20527118 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,15395338 0,20515225 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,15395338 0,20503346 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,15395338 0,2049148 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,15395338 0,20479629 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,15395338 0,20467791 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,15655732 0,20801954 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,15655732 0,20789944 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,15655732 0,20777947 ! negative regulation of transport GO:0051051 116 73 1,000 0,15998853 0,21221085 ! positive regulation of translation GO:0045727 28 18 0,000 0,16223703 0,21506927 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,16223703 0,21494538 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,16223703 0,21482163 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,16223703 0,21469803 ! cAMP metabolic process GO:0046058 33 18 0,000 0,16223703 0,21457457 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,16223703 0,21445125 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,16223703 0,21432808 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,16223703 0,21420504 ! axis specification GO:0009798 26 18 0,000 0,16223703 0,21408215 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,16223703 0,21395939 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,16223703 0,21383678 ! pancreas development GO:0031016 26 18 0,000 0,16223703 0,21371431 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,16223703 0,21359197 ! glutamine metabolic process GO:0006541 23 18 0,000 0,16223703 0,21346978 ! response to retinoic acid GO:0032526 25 18 0,000 0,16223703 0,21334773 ! pigmentation during development GO:0048066 31 18 0,000 0,16223703 0,21322582 ! central nervous system neuron development GO:0021954 30 18 0,000 0,16223703 0,21310404 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,16223703 0,21298241 ! fucose metabolic process GO:0006004 26 18 0,000 0,16223703 0,21286091 ! response to fungus GO:0009620 19 18 0,000 0,16223703 0,21273956 ! peptide cross-linking GO:0018149 31 18 0,000 0,16223703 0,21261834 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,16223703 0,21249725 ! heart process GO:0003015 27 18 0,000 0,16223703 0,21237631 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,16223703 0,21225551 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,16223703 0,21213484 ! visual learning GO:0008542 35 18 0,000 0,16223703 0,21201431 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,16223703 0,21189391 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,16223703 0,21177365 ! vitamin transport GO:0051180 24 18 0,000 0,16223703 0,21165353 ! hormone transport GO:0009914 27 18 0,000 0,16223703 0,21153355 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,16223703 0,2114137 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,16223703 0,21129399 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,16223703 0,21117441 ! cell-cell recognition GO:0009988 20 18 0,000 0,16223703 0,21105497 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,16223703 0,21093566 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,16223703 0,21081649 ! regulation of glucose import GO:0046324 21 18 0,000 0,16223703 0,21069745 GO:0010827|regulation of glucose transport, ! response to nutrient GO:0007584 104 75 1,000 0,16689201 0,21662055 ! regulation of ligase activity GO:0051340 114 75 1,000 0,16689201 0,21649837 ! tRNA metabolic process GO:0006399 95 76 1,000 0,1703631 0,22087662 ! response to unfolded protein GO:0006986 99 76 1,000 0,1703631 0,22075218 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,1703631 0,22062789 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,17044005 0,22060333 ! positive regulation of ossification GO:0045778 30 19 0,000 0,17044005 0,22047926 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,17044005 0,22035532 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,17044005 0,22023153 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,17044005 0,22010787 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,17044005 0,21998435 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,17044005 0,21986097 ! sensory perception of taste GO:0050909 23 19 0,000 0,17044005 0,21973773 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,17044005 0,21961463 ! smooth muscle contraction GO:0006939 36 19 0,000 0,17044005 0,21949167 ! peroxisome organization GO:0007031 29 19 0,000 0,17044005 0,21936884 ! digestive system process GO:0022600 30 19 0,000 0,17044005 0,21924615 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,17044005 0,2191236 ! response to vitamin A GO:0033189 26 19 0,000 0,17044005 0,21900118 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,17044005 0,2188789 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,17044005 0,21875676 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,17044005 0,21863476 ! plasma membrane fusion GO:0045026 23 19 0,000 0,17044005 0,21851289 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,17044005 0,21839115 ! vasodilation GO:0042311 33 19 0,000 0,17044005 0,21826955 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,17044005 0,21814809 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,17044005 0,21802676 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,17044005 0,21790557 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,17044005 0,21778451 ! sarcomere organization GO:0045214 23 19 0,000 0,17044005 0,21766358 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,17044005 0,21754279 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,17044005 0,21742214 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,17044005 0,21730162 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,17044005 0,21718123 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,17044005 0,21706097 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,17044005 0,21694085 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,17044005 0,21682086 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,17384632 0,2210318 ! sex differentiation GO:0007548 105 77 1,000 0,17384632 0,22090968 ! protein ubiquitination GO:0016567 125 77 1,000 0,17384632 0,2207877 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,17384632 0,22066585 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,17384632 0,22054414 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,17384632 0,22042256 ! positive regulation of protein modification process GO:0031401 107 78 1,000 0,1773411 0,22472977 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,1773411 0,22460602 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,17856321 0,22602938 ! iron ion transport GO:0006826 37 20 0,000 0,17856321 0,22590505 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,17856321 0,22578086 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,17856321 0,2256568 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,17856321 0,22553289 ! response to vitamin GO:0033273 29 20 0,000 0,17856321 0,2254091 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,17856321 0,22528546 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,17856321 0,22516194 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,17856321 0,22503857 ! spinal cord development GO:0021510 31 20 0,000 0,17856321 0,22491533 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,17856321 0,22479222 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,17856321 0,22466925 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,17856321 0,22454641 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,17856321 0,22442371 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,17856321 0,22430114 ! pallium development GO:0021543 38 20 0,000 0,17856321 0,2241787 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,17856321 0,2240564 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,17856321 0,22393423 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,17856321 0,2238122 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,17856321 0,2236903 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,17856321 0,22356853 ! collagen catabolic process GO:0030574 25 20 0,000 0,17856321 0,22344689 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,17856321 0,22332539 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,17856321 0,22320401 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,17856321 0,22308277 ! alditol metabolic process GO:0019400 24 20 0,000 0,17856321 0,22296166 ! actin filament-based movement GO:0030048 34 20 0,000 0,17856321 0,22284069 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,1808469 0,22556825 ! regulation of lyase activity GO:0051339 133 79 1,000 0,1808469 0,225446 ! ATP biosynthetic process GO:0006754 118 79 1,000 0,1808469 0,22532387 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,18436316 0,22958054 ! forebrain development GO:0030900 131 80 1,000 0,18436316 0,22945631 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,18660729 0,23212372 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,18660729 0,23199825 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,18660729 0,23187291 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,18660729 0,23174771 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,18660729 0,23162265 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,18660729 0,23149772 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,18660729 0,23137292 GO:0034105|positive regulation of tissue remodeling, ! regulation of chemotaxis GO:0050920 36 21 0,000 0,18660729 0,23124826 ! vesicle docking GO:0048278 27 21 0,000 0,18660729 0,23112373 ! phototransduction GO:0007602 25 21 0,000 0,18660729 0,23099933 ! dendrite development GO:0016358 35 21 0,000 0,18660729 0,23087507 ! visual behavior GO:0007632 39 21 0,000 0,18660729 0,23075095 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,18660729 0,23062696 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,18660729 0,2305031 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,18660729 0,23037937 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,18660729 0,23025577 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,18660729 0,23013231 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,18660729 0,23000898 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,18660729 0,22988579 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,18660729 0,22976272 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,18660729 0,22963979 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,18660729 0,22951699 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,18660729 0,22939432 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,18660729 0,22927178 ! fatty acid transport GO:0015908 30 21 0,000 0,18660729 0,22914937 ! immunoglobulin production GO:0002377 33 21 0,000 0,18660729 0,22902709 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,18660729 0,22890494 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,18660729 0,22878292 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,18660729 0,22866104 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,18660729 0,22853928 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,18660729 0,22841765 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,18660729 0,22829615 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,18660729 0,22817478 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,18660729 0,22805354 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,18660729 0,22793243 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,18660729 0,22781145 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,18660729 0,22769059 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,18788935 0,22913335 ! mRNA transport GO:0051028 121 81 1,000 0,18788935 0,22901192 ! regulation of neurological system process GO:0031644 122 81 1,000 0,18788935 0,22889062 ! detection of stimulus GO:0051606 108 82 1,000 0,19142494 0,2330743 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,19457305 0,23678202 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,19457305 0,2366568 ! viral genome replication GO:0019079 29 22 0,000 0,19457305 0,23653172 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,19457305 0,23640677 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,19457305 0,23628195 ! leukocyte adhesion GO:0007159 38 22 0,000 0,19457305 0,23615726 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,19457305 0,23603271 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,19457305 0,23590828 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,19457305 0,23578399 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,19457305 0,23565983 ! vasculogenesis GO:0001570 33 22 0,000 0,19457305 0,2355358 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,19457305 0,2354119 GO:0051297|centrosome organization, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,19457305 0,23528813 ! lysosome organization GO:0007040 37 22 0,000 0,19457305 0,23516448 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,19457305 0,23504097 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,19457305 0,23491759 ! regulation of behavior GO:0050795 38 22 0,000 0,19457305 0,23479434 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,19457305 0,23467122 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,19457305 0,23454823 ! membrane depolarization GO:0051899 35 22 0,000 0,19457305 0,23442536 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,19457305 0,23430263 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,19457305 0,23418002 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,19457305 0,23405754 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,19457305 0,23393519 ! blastocyst development GO:0001824 37 22 0,000 0,19457305 0,23381296 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,19457305 0,23369087 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,19496941 0,2340447 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,19852227 0,2381853 ! Golgi vesicle transport GO:0048193 138 85 1,000 0,202083 0,24233102 ! rRNA metabolic process GO:0016072 107 85 1,000 0,202083 0,24220474 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,202083 0,24207859 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,202083 0,24195258 ! regulation of membrane potential GO:0042391 128 85 1,000 0,202083 0,24182669 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,202083 0,24170094 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,20246125 0,24202748 ! neuron fate commitment GO:0048663 32 23 0,000 0,20246125 0,24190176 ! embryonic pattern specification GO:0009880 31 23 0,000 0,20246125 0,24177616 ! myelination GO:0042552 35 23 0,000 0,20246125 0,24165069 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,20246125 0,24152535 ! vesicle targeting GO:0006903 32 23 0,000 0,20246125 0,24140014 ! osteoblast differentiation GO:0001649 40 23 0,000 0,20246125 0,24127507 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,20246125 0,24115012 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,20246125 0,2410253 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,20246125 0,24090061 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,20246125 0,24077605 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,20246125 0,24065162 ! cell fate determination GO:0001709 45 23 0,000 0,20246125 0,24052731 ! pentose metabolic process GO:0019321 31 23 0,000 0,20246125 0,24040314 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,20246125 0,24027909 ! spermatid development GO:0007286 33 23 0,000 0,20246125 0,24015517 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,20246125 0,24003138 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,20246125 0,23990772 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,20246125 0,23978418 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,20246125 0,23966077 ! telomere organization GO:0032200 32 23 0,000 0,20246125 0,23953749 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,20246125 0,23941433 ! regulation of amine transport GO:0051952 38 23 0,000 0,20246125 0,23929131 ! liver development GO:0001889 40 23 0,000 0,20246125 0,2391684 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,20565112 0,2428119 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 1,000 0,20922615 0,24690618 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,20922615 0,24677956 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 1,000 0,20922615 0,24665307 ! initiation of viral infection GO:0019059 42 24 0,000 0,21027265 0,24775978 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,21027265 0,24763292 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,21027265 0,24750619 ! superoxide metabolic process GO:0006801 32 24 0,000 0,21027265 0,24737958 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,21027265 0,24725311 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,21027265 0,24712677 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,21027265 0,24700055 ! sperm motility GO:0030317 27 24 0,000 0,21027265 0,24687447 ! vacuole organization GO:0007033 39 24 0,000 0,21027265 0,24674851 ! neural crest cell development GO:0014032 39 24 0,000 0,21027265 0,24662269 GO:0014033|neural crest cell differentiation, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,21027265 0,24649699 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,21027265 0,24637141 ! glutathione metabolic process GO:0006749 29 24 0,000 0,21027265 0,24624597 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,21027265 0,24612065 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,21027265 0,24599547 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 1,000 0,21280761 0,24883452 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,21280761 0,24870808 ! establishment of RNA localization GO:0051236 128 88 1,000 0,21280761 0,24858177 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 1,000 0,21639504 0,25264395 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,21639504 0,25251577 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,21800798 0,25426894 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,21800798 0,25414006 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,21800798 0,25401132 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,21800798 0,25388271 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,21800798 0,25375422 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,21800798 0,25362587 ! peptide transport GO:0015833 43 25 0,000 0,21800798 0,25349765 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,21800798 0,25336955 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,21800798 0,25324159 ! phospholipid transport GO:0015914 35 25 0,000 0,21800798 0,25311375 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,21800798 0,25298605 ! detection of light stimulus GO:0009583 30 25 0,000 0,21800798 0,25285847 ! RNA localization GO:0006403 135 91 1,000 0,22358598 0,25919746 ! ATP metabolic process GO:0046034 137 91 1,000 0,22358598 0,25906688 ! response to virus GO:0009615 122 91 1,000 0,22358598 0,25893643 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,22566798 0,26121608 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,22566798 0,26108468 ! translational initiation GO:0006413 43 26 0,000 0,22566798 0,26095342 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,22566798 0,26082228 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,22566798 0,26069128 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,22566798 0,26056041 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,22566798 0,26042968 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,22566798 0,26029907 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,22566798 0,26016859 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,22566798 0,26003825 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,22566798 0,25990803 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,22566798 0,25977795 ! regulation of coagulation GO:0050818 39 26 0,000 0,22566798 0,259648 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,22718861 0,26126691 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,23325338 0,26810733 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,23325338 0,26797341 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,23325338 0,26783963 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,23325338 0,26770597 ! membrane docking GO:0022406 39 27 0,000 0,23325338 0,26757245 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,23325338 0,26743907 ! catechol metabolic process GO:0009712 43 27 0,000 0,23325338 0,26730581 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,23325338 0,26717269 ! acute-phase response GO:0006953 42 27 0,000 0,23325338 0,26703971 ! myofibril assembly GO:0030239 36 27 0,000 0,23325338 0,26690685 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,23325338 0,26677413 ! natural killer cell activation GO:0030101 35 27 0,000 0,23325338 0,26664154 ! lipid oxidation GO:0034440 38 27 0,000 0,23325338 0,26650908 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,23325338 0,26637675 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,23325338 0,26624455 ! gene silencing GO:0016458 41 27 0,000 0,23325338 0,26611248 ! angiogenesis GO:0001525 149 95 1,000 0,23801998 0,27141594 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,2407649 0,27440995 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,2407649 0,27427404 ! phenol metabolic process GO:0018958 44 28 0,000 0,2407649 0,27413826 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,2407649 0,27400261 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,2407649 0,2738671 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,2407649 0,27373172 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,2407649 0,27359648 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,2407649 0,27346137 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,2407649 0,2733264 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,2407649 0,27319155 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,2407649 0,27305684 ! mesoderm formation GO:0001707 46 28 0,000 0,2407649 0,27292227 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,2407649 0,27278782 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,2407649 0,27265351 ! ensheathment of neurons GO:0007272 43 28 0,000 0,2407649 0,27251933 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,2407649 0,27238528 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,2407649 0,27225137 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,2407649 0,27211758 ! in utero embryonic development GO:0001701 147 96 1,000 0,24163687 0,27296896 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,24163687 0,27283496 ! regulation of innate immune response GO:0045088 38 29 0,000 0,24820327 0,28011164 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,24820327 0,27997426 ! protein targeting to membrane GO:0006612 53 29 0,000 0,24820327 0,27983702 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,24820327 0,27969991 ! mismatch repair GO:0006298 34 29 0,000 0,24820327 0,27956294 ! muscle cell development GO:0055001 38 29 0,000 0,24820327 0,2794261 ! formation of primary germ layer GO:0001704 48 29 0,000 0,24820327 0,27928939 ! telencephalon development GO:0021537 52 29 0,000 0,24820327 0,27915282 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,24820327 0,27901638 ! eye morphogenesis GO:0048592 51 29 0,000 0,24820327 0,27888008 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,24820327 0,2787439 ! calcium ion transport GO:0006816 167 99 1,000 0,25250125 0,28343235 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,25250125 0,28329409 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,25556918 0,28659635 ! collagen metabolic process GO:0032963 40 30 0,000 0,25556918 0,28645668 ! organic anion transport GO:0015711 51 30 0,000 0,25556918 0,28631715 ! cholesterol transport GO:0030301 46 30 0,000 0,25556918 0,28617776 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,25556918 0,2860385 ! spliceosome assembly GO:0000245 49 30 0,000 0,25556918 0,28589937 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,25556918 0,28576038 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,25556918 0,28562153 ! ceramide metabolic process GO:0006672 43 30 0,000 0,25556918 0,28548281 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,25556918 0,28534423 ! adult locomotory behavior GO:0008344 47 30 0,000 0,25556918 0,28520578 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,25556918 0,28506746 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,25556918 0,28492928 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 1,000 0,256126 0,28541172 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,256126 0,28527351 ! divalent metal ion transport GO:0070838 171 100 1,000 0,256126 0,28513543 ! negative regulation of secretion GO:0051048 49 31 0,000 0,26286334 0,29249428 ! glial cell differentiation GO:0010001 55 31 0,000 0,26286334 0,29235284 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,26286334 0,29221154 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,26286334 0,29207037 ! odontogenesis GO:0042476 50 31 0,000 0,26286334 0,29192935 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,26286334 0,29178845 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,26286334 0,2916477 ! cell fate specification GO:0001708 37 31 0,000 0,26286334 0,29150708 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,26286334 0,29136659 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,26286334 0,29122624 ! RNA modification GO:0009451 40 31 0,000 0,26286334 0,29108603 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,27008644 0,29894072 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,27008644 0,29879693 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,27008644 0,29865328 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 0,000 0,27008644 0,29850976 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,27008644 0,29836638 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,27008644 0,29822315 ! cytokine production GO:0001816 44 32 0,000 0,27008644 0,29808004 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,27008644 0,29793708 ! vesicle localization GO:0051648 47 32 0,000 0,27008644 0,29779425 ! RNA export from nucleus GO:0006405 44 33 0,000 0,27723917 0,30553431 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,27723917 0,30538798 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,27723917 0,30524179 ! actomyosin structure organization GO:0031032 43 33 0,000 0,27723917 0,30509574 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,27723917 0,30494983 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,27723917 0,30480406 ! lipid homeostasis GO:0055088 55 33 0,000 0,27723917 0,30465843 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,27723917 0,30451294 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,27723917 0,30436759 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,27723917 0,30422238 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,28432222 0,31184602 ! mRNA catabolic process GO:0006402 48 34 0,000 0,28432222 0,31169738 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,28432222 0,31154889 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,28432222 0,31140053 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,28432222 0,31125231 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,28432222 0,31110424 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,28432222 0,31095631 ! polyol metabolic process GO:0019751 44 34 0,000 0,28432222 0,31080851 ! aerobic respiration GO:0009060 47 34 0,000 0,28432222 0,31066086 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,28432222 0,31051335 ! embryonic organ development GO:0048568 45 34 0,000 0,28432222 0,31036598 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,28432222 0,31021874 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,29133626 0,31772091 ! Notch signaling pathway GO:0007219 56 35 0,000 0,29133626 0,31757033 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,29133626 0,31741989 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,29133626 0,3172696 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,29133626 0,31711945 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,29133626 0,31696944 ! protein homooligomerization GO:0051260 52 35 0,000 0,29133626 0,31681957 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,29828195 0,32421951 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,29828195 0,32406636 ! organic ether metabolic process GO:0018904 46 36 0,000 0,29828195 0,32391336 ! tissue remodeling GO:0048771 62 36 0,000 0,29828195 0,32376049 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,29828195 0,32360778 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,29828195 0,3234552 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,29828195 0,32330277 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,30515996 0,33060194 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,30515996 0,33044629 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,30515996 0,33029078 ! regulation of protein secretion GO:0050708 51 37 0,000 0,30515996 0,33013543 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,30515996 0,32998021 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,31197095 0,33718665 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,31197095 0,33702827 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,31197095 0,33687004 ! phagocytosis GO:0006909 60 38 0,000 0,31197095 0,33671196 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,31871556 0,3438301 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,31871556 0,34366891 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,31871556 0,34350786 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,31871556 0,34334697 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,31871556 0,34318623 ! chromatin remodeling GO:0006338 68 39 0,000 0,31871556 0,34302564 ! JNK cascade GO:0007254 54 39 0,000 0,31871556 0,34286519 ! cell growth GO:0016049 61 39 0,000 0,31871556 0,3427049 ! synapse organization GO:0050808 55 39 0,000 0,31871556 0,34254476 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,32539443 0,34955964 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,32539443 0,34939645 ! regulation of tube size GO:0035150 60 40 0,000 0,32539443 0,34923341 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,32539443 0,34907052 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,32539443 0,34890778 ! inner ear development GO:0048839 57 40 0,000 0,32539443 0,3487452 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,33200821 0,35566786 ! striated muscle contraction GO:0006941 62 41 0,000 0,33200821 0,35550228 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,33200821 0,35533685 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,33855753 0,36217782 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,33855753 0,36200944 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,33855753 0,36184122 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,33855753 0,36167316 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,33855753 0,36150525 ! excretion GO:0007588 63 42 0,000 0,33855753 0,3613375 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,33855753 0,36116991 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,33855753 0,36100246 ! leukocyte migration GO:0050900 60 43 0,000 0,345043 0,36774741 ! neuromuscular process GO:0050905 79 43 0,000 0,345043 0,36757708 ! tRNA processing GO:0008033 49 43 0,000 0,345043 0,3674069 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,35146525 0,37407223 ! glycolysis GO:0006096 53 44 0,000 0,35146525 0,37389921 ! regulation of action potential GO:0001508 71 44 0,000 0,35146525 0,37372635 ! regulation of ion transport GO:0043269 57 44 0,000 0,35146525 0,37355364 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,35146525 0,3733811 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,35146525 0,37320872 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,35146525 0,37303649 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,35146525 0,37286443 ! RNA catabolic process GO:0006401 64 45 0,000 0,3578249 0,37943627 ! positive regulation of defense response GO:0031349 59 45 0,000 0,3578249 0,37926141 ! regulation of translational initiation GO:0006446 64 45 0,000 0,3578249 0,37908672 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,3578249 0,37891218 ! cell recognition GO:0008037 58 45 0,000 0,3578249 0,37873781 ! cell maturation GO:0048469 60 45 0,000 0,3578249 0,3785636 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,36412254 0,38504912 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,36412254 0,38487217 ! cell redox homeostasis GO:0045454 63 46 0,000 0,36412254 0,38469538 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,36412254 0,38451875 ! viral infectious cycle GO:0019058 71 47 0,000 0,37035877 0,39092482 ! endocrine system development GO:0035270 83 47 0,000 0,37035877 0,3907455 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,37035877 0,39056634 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,37035877 0,39038734 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,37035877 0,39020851 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,37653421 0,39653328 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,37653421 0,3963518 ! gastrulation GO:0007369 73 48 0,000 0,37653421 0,39617048 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,37653421 0,39598933 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,37653421 0,39580835 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,38264942 0,40205284 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,38264942 0,40186925 ! sensory perception of smell GO:0007608 61 49 0,000 0,38264942 0,40168584 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,38264942 0,40150259 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,38264942 0,4013195 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,38264942 0,40113658 ! cartilage development GO:0051216 70 49 0,000 0,38264942 0,40095383 ! regulation of actin filament length GO:0030832 72 50 0,000 0,388705 0,40711362 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,388705 0,40692831 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,388705 0,40674318 ! lipid modification GO:0030258 73 50 0,000 0,388705 0,40655821 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,388705 0,40637341 ! positive regulation of secretion GO:0051047 71 51 0,000 0,39470153 0,41245503 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,39470153 0,41226772 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,39470153 0,41208058 ! adult behavior GO:0030534 80 51 0,000 0,39470153 0,41189361 ! transition metal ion transport GO:0000041 74 52 0,000 0,40063957 0,41790069 ! regulation of cellular component size GO:0032535 74 52 0,000 0,40063957 0,41771125 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,40063957 0,41752198 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,40063957 0,41733289 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,4065197 0,42326632 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,4065197 0,4230748 ! single fertilization GO:0007338 59 53 0,000 0,4065197 0,42288345 ! amino acid transport GO:0006865 84 54 0,000 0,41234247 0,4287467 ! glucose catabolic process GO:0006007 66 54 0,000 0,41234247 0,42855296 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,41234247 0,42835939 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,41234247 0,428166 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,41234247 0,42797278 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,41234247 0,42777974 ! exocytosis GO:0006887 74 55 0,000 0,41810845 0,43356602 ! mesoderm development GO:0007498 76 55 0,000 0,41810845 0,43337063 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,41810845 0,43317542 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,41810845 0,43298039 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,42381818 0,43869569 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,42947221 0,44434821 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,42947221 0,44414842 ! camera-type eye development GO:0043010 88 57 0,000 0,42947221 0,4439488 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,43507107 0,44953435 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,44061531 0,45505848 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,44610546 0,46052179 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,44610546 0,46031519 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,44610546 0,46010877 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,44610546 0,45990253 ! regulation of heart contraction GO:0008016 91 60 0,000 0,44610546 0,45969649 ! fertilization GO:0009566 68 60 0,000 0,44610546 0,45949062 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,45154203 0,46488213 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,45154203 0,46467413 ! extracellular matrix organization GO:0030198 103 61 0,000 0,45154203 0,46446631 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,45154203 0,46425868 ! amine catabolic process GO:0009310 90 62 0,000 0,45692555 0,4695839 ! neurotransmitter transport GO:0006836 81 62 0,000 0,45692555 0,46937417 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,45692555 0,46916463 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,45692555 0,46895527 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,46225654 0,474215 ! regulation of lipase activity GO:0060191 109 63 0,000 0,46225654 0,47400358 ! appendage morphogenesis GO:0035107 93 64 0,000 0,46753549 0,47920304 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,46753549 0,47898959 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,46753549 0,47877633 ! hexose catabolic process GO:0019320 82 64 0,000 0,46753549 0,47856325 ! appendage development GO:0048736 94 65 0,000 0,47276292 0,48369872 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,47276292 0,48348365 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,47276292 0,48326877 ! defense response to bacterium GO:0042742 73 65 0,000 0,47276292 0,48305408 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,47276292 0,48283958 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,47793933 0,48790966 ! axon guidance GO:0007411 99 66 0,000 0,47793933 0,4876932 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,48306522 0,4927051 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,48814106 0,49766154 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,48814106 0,49744105 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,49316736 0,50234053 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,49316736 0,50211816 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,49814458 0,5069613 ! eye development GO:0001654 111 70 0,000 0,49814458 0,50673708 ! amine transport GO:0015837 101 70 0,000 0,49814458 0,50651306 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,50307321 0,51129844 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,50307321 0,51107261 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,50307321 0,51084697 ! regulation of blood pressure GO:0008217 107 73 0,000 0,51278656 0,52048062 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,51278656 0,52025103 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,51757222 0,52487483 ! digestion GO:0007586 97 74 0,000 0,51757222 0,5246435 ! blood coagulation GO:0007596 116 75 0,000 0,52231114 0,52921393 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,52231114 0,5289809 ! amine biosynthetic process GO:0009309 97 76 0,000 0,52700378 0,53349855 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,53165059 0,53796584 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,53625201 0,5423833 ! chromatin assembly GO:0031497 102 80 0,000 0,54532046 0,55131299 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,54532046 0,55107076 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,54532046 0,55082874 GO:0010498|proteasomal protein catabolic process, ! hemostasis GO:0007599 125 81 0,000 0,54978834 0,55509798 ! vitamin metabolic process GO:0006766 103 81 0,000 0,54978834 0,55485441 ! ossification GO:0001503 134 82 0,000 0,55421258 0,5590741 GO:0060348|bone development, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,5585936 0,5632465 ! regulation of defense response GO:0031347 117 84 0,000 0,56293181 0,56737211 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,56293181 0,56712359 ! sterol metabolic process GO:0016125 120 84 0,000 0,56293181 0,56687529 ! nucleosome organization GO:0034728 114 87 0,000 0,57569374 0,57947291 ! cellular defense response GO:0006968 102 87 0,000 0,57569374 0,57921942 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,57986484 0,58316097 GO:0016054|organic acid catabolic process, ! hormone metabolic process GO:0042445 121 90 0,000 0,58808515 0,59116951 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,59614554 0,59901037 ! DNA recombination GO:0006310 146 92 0,000 0,59614554 0,5987488 ! sulfur metabolic process GO:0006790 118 92 0,000 0,59614554 0,59848745 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,60011674 0,60221139 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,60011674 0,60194876 ! carboxylic acid transport GO:0046942 147 95 0,000 0,60794304 0,60953313 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,61179889 0,61313179 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,61561705 0,61668955 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! extracellular structure organization GO:0043062 156 99 0,000 0,6231417 0,62395556 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,62684893 0,62739449 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,62684893 0,6271216 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,62684893 0,62684893