pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1308-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 4,000 5,091E-09 1,244E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 3,000 6,997E-09 8,547E-06 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 2,000 2,023E-07 1,648E-04 ! establishment of spindle localization GO:0051293 16 6 2,000 2,023E-07 1,236E-04 GO:0051653|spindle localization, ! platelet activating factor metabolic process GO:0046469 12 7 2,000 3,536E-07 1,727E-04 ! cerebral cortex cell migration GO:0021795 18 9 2,000 8,458E-07 3,444E-04 ! brain morphogenesis GO:0048854 23 10 2,000 1,206E-06 4,21E-04 ! central nervous system neuron axonogenesis GO:0021955 23 10 2,000 1,206E-06 3,684E-04 GO:0021952|central nervous system projection neuron axonogenesis, ! androgen receptor signaling pathway GO:0030521 81 37 3,000 1,341E-06 3,64E-04 ! telencephalon cell migration GO:0022029 23 11 2,000 1,656E-06 4,046E-04 ! neuroblast proliferation GO:0007405 25 11 2,000 1,656E-06 3,678E-04 ! hippocampus development GO:0021766 29 12 2,000 2,205E-06 4,489E-04 ! forebrain cell migration GO:0021885 24 12 2,000 2,205E-06 4,143E-04 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 4,538E-06 7,919E-04 ! axon cargo transport GO:0008088 46 16 2,000 5,577E-06 9,083E-04 ! limbic system development GO:0021761 40 18 2,000 8,101E-06 1,237E-03 ! cerebral cortex development GO:0021987 40 19 2,000 9,604E-06 1,38E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 1,128E-05 1,531E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 1,394E-05 1,793E-03 ! microtubule-based transport GO:0010970 59 22 2,000 1,519E-05 1,856E-03 ! central nervous system neuron development GO:0021954 47 22 2,000 1,519E-05 1,767E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 1,519E-05 1,687E-03 ! regulation of Rho GTPase activity GO:0032319 56 23 2,000 1,744E-05 1,853E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 1,864E-05 1,898E-03 ! central nervous system neuron differentiation GO:0021953 51 24 2,000 1,99E-05 1,945E-03 ! pallium development GO:0021543 56 24 2,000 1,99E-05 1,87E-03 ! neuromuscular process controlling balance GO:0050885 67 29 2,000 3,565E-05 3,226E-03 ! ethanolamine and derivative metabolic process GO:0042439 48 29 2,000 3,565E-05 3,11E-03 ! response to superoxide GO:0000303 10 5 1,000 4,734E-05 3,988E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 4,734E-05 3,855E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 4,734E-05 3,731E-03 ! adult locomotory behavior GO:0008344 62 34 2,000 5,792E-05 4,422E-03 ! telencephalon development GO:0021537 81 35 2,000 6,325E-05 4,682E-03 ! response to oxygen radical GO:0000305 11 6 1,000 7,091E-05 5,095E-03 ! malate metabolic process GO:0006108 13 6 1,000 7,091E-05 4,949E-03 ! oxygen homeostasis GO:0032364 10 6 1,000 7,091E-05 4,812E-03 ! removal of superoxide radicals GO:0019430 12 6 1,000 7,091E-05 4,682E-03 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 2,000 8,114E-05 5,216E-03 ! spermatid development GO:0007286 69 38 2,000 8,114E-05 5,083E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 9,913E-05 6,054E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 9,913E-05 5,906E-03 ! establishment of tissue polarity GO:0007164 8 7 1,000 9,913E-05 5,766E-03 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 1,000 9,913E-05 5,632E-03 ! mesenchymal cell development GO:0014031 94 41 2,000 1,02E-04 5,666E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! spermatid differentiation GO:0048515 73 41 2,000 1,02E-04 5,54E-03 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 1,097E-04 5,827E-03 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 2,000 1,178E-04 6,121E-03 ! neuron migration GO:0001764 85 43 2,000 1,178E-04 5,994E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,32E-04 6,58E-03 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 1,000 1,32E-04 6,449E-03 ! ER overload response GO:0006983 13 8 1,000 1,32E-04 6,322E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 1,32E-04 6,201E-03 ! gas homeostasis GO:0033483 14 8 1,000 1,32E-04 6,084E-03 ! glycolysis GO:0006096 71 46 2,000 1,442E-04 6,522E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 1,442E-04 6,404E-03 ! positive regulation of protein transport GO:0051222 80 46 2,000 1,442E-04 6,29E-03 ! microtubule bundle formation GO:0001578 22 9 1,000 1,694E-04 7,262E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,694E-04 7,137E-03 ! negative regulation of blood pressure GO:0045776 26 10 1,000 2,115E-04 8,758E-03 ! induction of an organ GO:0001759 17 10 1,000 2,115E-04 8,612E-03 ! neuromuscular process GO:0050905 107 54 2,000 2,326E-04 9,316E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 2,581E-04 0,01017155 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,581E-04 0,01001009 ! glucose catabolic process GO:0006007 88 56 2,000 2,592E-04 9,892E-03 ! regulation of intracellular transport GO:0032386 108 57 2,000 2,731E-04 0,01026497 ! establishment of organelle localization GO:0051656 122 59 2,000 3,025E-04 0,01119662 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 3,093E-04 0,01127889 ! mitotic spindle organization GO:0007052 23 12 1,000 3,093E-04 0,01111303 ! histone acetylation GO:0016573 27 12 1,000 3,093E-04 0,01095197 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,093E-04 0,01079551 ! developmental induction GO:0031128 22 12 1,000 3,093E-04 0,01064346 GO:0045168|cell-cell signaling involved in cell fate specification, ! localization within membrane GO:0051668 26 12 1,000 3,093E-04 0,01049564 ! adult behavior GO:0030534 104 60 2,000 3,179E-04 0,01063897 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 3,65E-04 0,01205152 ! response to gamma radiation GO:0010332 30 14 1,000 4,253E-04 0,01385289 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 4,253E-04 0,01367062 ! hexose catabolic process GO:0019320 113 68 2,000 4,597E-04 0,01458657 ! lung development GO:0030324 165 69 2,000 4,799E-04 0,0150304 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 4,9E-04 0,01515319 ! germ cell development GO:0007281 133 70 2,000 5,006E-04 0,01528672 ! respiratory tube development GO:0030323 171 72 2,000 5,437E-04 0,01639775 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 5,592E-04 0,01666062 ! neuron recognition GO:0008038 40 16 1,000 5,592E-04 0,01645989 ! respiratory system development GO:0060541 175 74 2,000 5,891E-04 0,01713249 ! organelle localization GO:0051640 155 74 2,000 5,891E-04 0,01693093 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 6,329E-04 0,01797819 GO:0031114|regulation of microtubule depolymerization, ! learning or memory GO:0007611 161 76 2,000 6,368E-04 0,01788268 ! monosaccharide catabolic process GO:0046365 125 77 2,000 6,616E-04 0,01836727 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 7,11E-04 0,01951591 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 7,11E-04 0,01929907 ! protein export from nucleus GO:0006611 40 19 1,000 7,935E-04 0,02130218 ! response to oxygen levels GO:0070482 183 83 2,000 8,232E-04 0,02186 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 8,804E-04 0,02312715 ! protein amino acid acetylation GO:0006473 41 20 1,000 8,804E-04 0,02288112 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 8,804E-04 0,02264027 ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 8,804E-04 0,02240443 ! alcohol catabolic process GO:0046164 142 87 2,000 9,437E-04 0,02376805 ! regulation of protein transport GO:0051223 165 87 2,000 9,437E-04 0,02352552 GO:0070201|regulation of establishment of protein localization, ! lipid phosphorylation GO:0046834 43 21 1,000 9,717E-04 0,02397827 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 9,717E-04 0,02373849 ! cellular respiration GO:0045333 143 88 2,000 9,755E-04 0,02359526 ! vasodilation GO:0042311 40 22 1,000 1,067E-03 0,02556394 ! detection of chemical stimulus GO:0009593 42 22 1,000 1,067E-03 0,02531575 ! peptidyl-serine modification GO:0018209 50 22 1,000 1,067E-03 0,02507233 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 1,000 1,167E-03 0,02715999 ! acetyl-CoA catabolic process GO:0046356 37 23 1,000 1,167E-03 0,02690377 GO:0006099|tricarboxylic acid cycle, ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 1,272E-03 0,02903396 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 1,272E-03 0,02876513 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 1,272E-03 0,02850123 ! biogenic amine metabolic process GO:0006576 162 97 2,000 1,292E-03 0,02869958 ! regulation of protein localization GO:0032880 188 97 2,000 1,292E-03 0,02844103 ! forebrain development GO:0030900 210 98 2,000 1,331E-03 0,02903156 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 1,38E-03 0,02984052 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 1,493E-03 0,03199814 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 1,493E-03 0,0317199 ! coenzyme catabolic process GO:0009109 42 26 1,000 1,493E-03 0,03144645 ! acetyl-CoA metabolic process GO:0006084 41 27 1,000 1,61E-03 0,03362408 ! superoxide metabolic process GO:0006801 41 27 1,000 1,61E-03 0,03333913 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 1,61E-03 0,03305896 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 1,732E-03 0,03525515 ! protein amino acid acylation GO:0043543 59 28 1,000 1,732E-03 0,03496378 ! dendrite development GO:0016358 67 28 1,000 1,732E-03 0,0346772 ! regulation of systemic arterial blood pressure GO:0003073 55 28 1,000 1,732E-03 0,03439527 ! glutathione metabolic process GO:0006749 42 28 1,000 1,732E-03 0,03411789 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 1,857E-03 0,03630037 ! somitogenesis GO:0001756 52 29 1,000 1,857E-03 0,03601227 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 1,857E-03 0,03572871 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 2,121E-03 0,04048595 ! cofactor catabolic process GO:0051187 54 31 1,000 2,121E-03 0,0401721 ! spindle organization GO:0007051 50 32 1,000 2,259E-03 0,04246029 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 2,259E-03 0,04213616 ! response to ionizing radiation GO:0010212 74 33 1,000 2,402E-03 0,04445166 ! response to hydrogen peroxide GO:0042542 56 34 1,000 2,548E-03 0,04680828 ! post-embryonic development GO:0009791 76 34 1,000 2,548E-03 0,04645897 ! cell fate specification GO:0001708 56 34 1,000 2,548E-03 0,04611483 ! calcium-mediated signaling GO:0019722 67 35 1,000 2,699E-03 0,04848118 ! aerobic respiration GO:0009060 56 36 1,000 2,854E-03 0,05088605 ! regulation of microtubule-based process GO:0032886 86 37 1,000 3,012E-03 0,0533283 ! glycogen metabolic process GO:0005977 63 38 1,000 3,175E-03 0,05580678 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 3,175E-03 0,05540816 ! glucan metabolic process GO:0044042 64 39 1,000 3,342E-03 0,0579068 GO:0006073|cellular glucan metabolic process, ! RNA export from nucleus GO:0006405 61 41 1,000 3,688E-03 0,06344892 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 4,05E-03 0,06918614 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 4,05E-03 0,06870569 ! regulation of tube size GO:0035150 76 43 1,000 4,05E-03 0,06823185 GO:0050880|regulation of blood vessel size, ! segmentation GO:0035282 78 43 1,000 4,05E-03 0,06776451 ! energy reserve metabolic process GO:0006112 76 44 1,000 4,237E-03 0,0704086 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 4,237E-03 0,06993287 ! double-strand break repair GO:0006302 85 44 1,000 4,237E-03 0,06946352 ! response to reactive oxygen species GO:0000302 75 44 1,000 4,237E-03 0,06900043 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 4,427E-03 0,07162997 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 1,000 4,622E-03 0,07428788 ! cell growth GO:0016049 90 46 1,000 4,622E-03 0,07380233 ! response to insulin stimulus GO:0032868 98 47 1,000 4,821E-03 0,07647349 ! positive regulation of cell cycle GO:0045787 96 48 1,000 5,023E-03 0,07917139 ! positive regulation of DNA binding GO:0043388 83 48 1,000 5,023E-03 0,07866388 ! vascular process in circulatory system GO:0003018 85 48 1,000 5,023E-03 0,07816283 ! protein homooligomerization GO:0051260 84 49 1,000 5,229E-03 0,08085857 ! peptide metabolic process GO:0006518 80 51 1,000 5,654E-03 0,08686787 ! positive regulation of binding GO:0051099 88 52 1,000 5,872E-03 0,08965096 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 5,872E-03 0,08909412 ! histone modification GO:0016570 104 52 1,000 5,872E-03 0,08854415 ! respiratory electron transport chain GO:0022904 83 53 1,000 6,093E-03 0,09132262 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 6,093E-03 0,09076578 ! activation of phospholipase C activity GO:0007202 110 54 1,000 6,319E-03 0,09355305 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 1,000 6,319E-03 0,09298947 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 6,548E-03 0,09578507 ! cell recognition GO:0008037 98 55 1,000 6,548E-03 0,09521492 ! response to UV GO:0009411 120 55 1,000 6,548E-03 0,09465152 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 6,781E-03 0,0974418 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 1,000 7,017E-03 0,1002527 ! regulation of phospholipase activity GO:0010517 113 57 1,000 7,017E-03 0,09966983 ! positive regulation of cell migration GO:0030335 137 58 1,000 7,258E-03 0,10248774 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 7,258E-03 0,10189873 ! aging GO:0007568 112 58 1,000 7,258E-03 0,10131645 ! positive regulation of lipase activity GO:0060193 115 58 1,000 7,258E-03 0,10074079 ! nuclear export GO:0051168 110 59 1,000 7,502E-03 0,10353994 ! lipid modification GO:0030258 112 60 1,000 7,749E-03 0,10635808 ! protein amino acid autophosphorylation GO:0046777 157 64 1,000 8,777E-03 0,11978434 ! response to peptide hormone stimulus GO:0043434 129 64 1,000 8,777E-03 0,11911887 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 9,043E-03 0,12204891 ! positive regulation of cell motion GO:0051272 157 65 1,000 9,043E-03 0,12137831 ! regulation of lipase activity GO:0060191 137 68 1,000 9,861E-03 0,13164735 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,01014147 0,13465009 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01092488 0,14426743 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01092488 0,1434918 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01092488 0,14272446 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01092488 0,14196529 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01092488 0,14121415 ! neuron fate determination GO:0048664 7 5 0,000 0,01092488 0,14047092 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01092488 0,13973547 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01092488 0,13900768 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01092488 0,13828743 ! polyol transport GO:0015791 12 5 0,000 0,01092488 0,13757461 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01092488 0,1368691 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01092488 0,13617079 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01092488 0,13547957 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01092488 0,13479532 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01092488 0,13411796 ! female meiosis GO:0007143 10 5 0,000 0,01092488 0,13344737 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01092488 0,13278345 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01092488 0,13212611 ! hypothalamus development GO:0021854 9 5 0,000 0,01092488 0,13147524 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01092488 0,13083076 ! cobalt ion transport GO:0006824 11 5 0,000 0,01092488 0,13019256 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01092488 0,12956055 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01092488 0,12893466 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01092488 0,12831478 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01092488 0,12770083 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01092488 0,12709273 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01092488 0,1264904 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01092488 0,12589375 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01092488 0,1253027 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01092488 0,12471717 ! transposition GO:0032196 9 5 0,000 0,01092488 0,12413709 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01092488 0,12356238 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01092488 0,12299297 ! negative chemotaxis GO:0050919 16 5 0,000 0,01092488 0,12242878 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01092488 0,12186975 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01092488 0,12131579 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01092488 0,12076685 ! behavioral response to pain GO:0048266 10 5 0,000 0,01092488 0,12022286 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01092488 0,11968374 ! Notch receptor processing GO:0007220 11 5 0,000 0,01092488 0,11914944 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01092488 0,11861989 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01092488 0,11809502 ! micturition GO:0060073 9 5 0,000 0,01092488 0,11757478 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01092488 0,1170591 ! copulation GO:0007620 9 5 0,000 0,01092488 0,11654792 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01092488 0,11604119 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01092488 0,11553885 ! bioluminescence GO:0008218 9 5 0,000 0,01092488 0,11504084 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01092488 0,1145471 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01092488 0,11405758 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01092488 0,11357223 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01092488 0,11309099 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01092488 0,11261382 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01092488 0,11214065 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01092488 0,11167144 ! grooming behavior GO:0007625 6 5 0,000 0,01092488 0,11120614 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01092488 0,11074471 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01092488 0,11028708 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01092488 0,10983323 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01092488 0,10938309 ! response to protozoan GO:0001562 13 5 0,000 0,01092488 0,10893663 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,01092488 0,1084938 ! lymph vessel development GO:0001945 10 5 0,000 0,01092488 0,10805455 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01092488 0,10761885 ! endochondral ossification GO:0001958 17 5 0,000 0,01092488 0,10718664 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01092488 0,1067579 ! single strand break repair GO:0000012 8 5 0,000 0,01092488 0,10633257 ! parathyroid gland development GO:0060017 14 5 0,000 0,01092488 0,10591061 ! anagen GO:0042640 7 5 0,000 0,01092488 0,10549199 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01092488 0,10507667 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01092488 0,10466461 ! cytokine secretion GO:0050663 15 5 0,000 0,01092488 0,10425576 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01092488 0,10385009 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01092488 0,10344757 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01092488 0,10304816 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01092488 0,10265182 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01092488 0,10225852 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01092488 0,10186822 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01092488 0,10148089 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01092488 0,10109649 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01092488 0,100715 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01092488 0,10033637 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01092488 0,09996058 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01092488 0,09958759 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01092488 0,09921738 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01092488 0,0988499 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01092488 0,09848515 ! microvillus organization GO:0032528 8 5 0,000 0,01092488 0,09812307 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01092488 0,09776364 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01092488 0,09740684 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01092488 0,09705263 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01092488 0,09670099 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01092488 0,09635189 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01092488 0,0960053 ! polyol catabolic process GO:0046174 9 5 0,000 0,01092488 0,0956612 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01092488 0,09531955 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01092488 0,09498034 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01092488 0,09464353 ! muscle cell migration GO:0014812 8 5 0,000 0,01092488 0,0943091 ! mitochondrial fission GO:0000266 8 5 0,000 0,01092488 0,09397702 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01092488 0,09364728 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01092488 0,09331984 ! mRNA transcription GO:0009299 10 5 0,000 0,01092488 0,09299468 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01092488 0,09267179 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01092488 0,09235112 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01092488 0,09203267 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01092488 0,09171641 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01092488 0,09140231 ! monocyte activation GO:0042117 10 5 0,000 0,01092488 0,09109036 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01092488 0,09078052 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01092488 0,09047279 ! response to food GO:0032094 6 5 0,000 0,01092488 0,09016714 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01092488 0,08986355 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01092488 0,08956199 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01092488 0,08926246 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01092488 0,08896491 ! forebrain neuron development GO:0021884 13 5 0,000 0,01092488 0,08866935 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01092488 0,08837574 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01092488 0,08808407 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01092488 0,08779432 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01092488 0,08750647 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01092488 0,0872205 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01092488 0,0869364 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01092488 0,08665414 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01092488 0,0863737 ! lipid glycosylation GO:0030259 7 5 0,000 0,01092488 0,08609508 ! nucleobase transport GO:0015851 6 5 0,000 0,01092488 0,08581825 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01092488 0,08554319 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01092488 0,08526989 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01092488 0,08499833 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01092488 0,08472849 ! basic amino acid transport GO:0015802 12 5 0,000 0,01092488 0,08446036 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01092488 0,08419393 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01092488 0,08392916 ! actin nucleation GO:0045010 11 5 0,000 0,01092488 0,08366606 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01092488 0,08340461 ! depurination GO:0045007 5 5 0,000 0,01092488 0,08314478 ! depyrimidination GO:0045008 10 5 0,000 0,01092488 0,08288657 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01092488 0,08262995 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01092488 0,08237492 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01092488 0,08212146 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01092488 0,08186955 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01092488 0,08161919 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01092488 0,08137035 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01092488 0,08112302 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01092488 0,08087719 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01092488 0,08063285 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01092488 0,08038998 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01092488 0,08014857 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01092488 0,07990861 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01092488 0,07967007 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01092488 0,07943296 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01092488 0,07919725 ! response to arsenic GO:0046685 11 5 0,000 0,01092488 0,07896294 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01092488 0,07873001 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01092488 0,07849845 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01092488 0,07826825 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01092488 0,0780394 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01092488 0,07781188 ! response to mercury ion GO:0046689 8 5 0,000 0,01092488 0,07758568 ! response to cadmium ion GO:0046686 7 5 0,000 0,01092488 0,0773608 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01092488 0,07713721 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01092488 0,07691491 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01092488 0,07669389 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01092488 0,07647414 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01092488 0,07625564 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01092488 0,07603839 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01092488 0,07582237 ! decidualization GO:0046697 11 5 0,000 0,01092488 0,07560758 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01092488 0,075394 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01092488 0,07518162 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01092488 0,07497043 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01092488 0,07476043 ! embryonic cleavage GO:0040016 6 5 0,000 0,01092488 0,0745516 ! peroxisome fission GO:0016559 5 5 0,000 0,01092488 0,07434394 ! histone demethylation GO:0016577 13 5 0,000 0,01092488 0,07413743 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01092488 0,07393206 ! mitotic recombination GO:0006312 9 5 0,000 0,01092488 0,07372783 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01092488 0,07352472 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01092488 0,07332273 ! metaphase plate congression GO:0051310 7 5 0,000 0,01092488 0,07312185 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01092488 0,07292206 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01092488 0,07272336 ! enteric nervous system development GO:0048484 8 5 0,000 0,01092488 0,07252575 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01092488 0,0723292 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01092488 0,07213371 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01092488 0,07193928 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01092488 0,0717459 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01092488 0,07155355 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01092488 0,07136223 ! B cell homeostasis GO:0001782 13 5 0,000 0,01092488 0,07117193 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01092488 0,07098264 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01092488 0,07079436 ! metaphase GO:0051323 11 5 0,000 0,01092488 0,07060707 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01092488 0,07042078 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01092488 0,07023546 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01092488 0,07005111 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01092488 0,06986773 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01092488 0,06968531 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01092488 0,06950384 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01092488 0,06932331 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01092488 0,06914372 ! response to redox state GO:0051775 6 5 0,000 0,01092488 0,06896505 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01092488 0,0687873 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01092488 0,06861047 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01092488 0,06843455 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01092488 0,06825953 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01092488 0,06808539 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01092488 0,06791215 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01092488 0,06773978 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01092488 0,06756829 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01092488 0,06739766 ! striatum development GO:0021756 14 5 0,000 0,01092488 0,0672279 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01092488 0,06705898 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01092488 0,06689091 ! glial cell migration GO:0008347 10 5 0,000 0,01092488 0,06672369 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01092488 0,06655729 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01092488 0,06639173 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01092488 0,06622698 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01092488 0,06606306 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01092488 0,06589994 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01092488 0,06573762 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01092488 0,0655761 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01092488 0,06541538 ! neuroprotection GO:0043526 8 5 0,000 0,01092488 0,06525544 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01092488 0,06509628 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01092488 0,06493789 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01092488 0,06478028 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01092488 0,06462342 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01092488 0,06446733 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01092488 0,06431199 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01092488 0,06415739 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01092488 0,06400354 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01092488 0,06385042 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01092488 0,06369803 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01092488 0,06354637 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01092488 0,06339543 ! spindle assembly GO:0051225 6 5 0,000 0,01092488 0,0632452 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01092488 0,06309568 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01092488 0,06294687 ! protein palmitoylation GO:0018345 12 5 0,000 0,01092488 0,06279876 ! drug metabolic process GO:0017144 7 5 0,000 0,01092488 0,06265135 ! stem cell division GO:0017145 11 5 0,000 0,01092488 0,06250462 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01092488 0,06235858 ! organ regeneration GO:0031100 7 5 0,000 0,01092488 0,06221323 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01092488 0,06206854 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01092488 0,06192453 ! regulation of caspase activity GO:0043281 136 74 1,000 0,01159402 0,06556525 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,01189488 0,06711128 GO:0090046|regulation of transcription regulator activity, ! regulation of blood pressure GO:0008217 134 76 1,000 0,01219915 0,0686694 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,01250682 0,07023943 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,01250682 0,07007833 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01309567 0,0732099 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01309567 0,07304275 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01309567 0,07287637 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01309567 0,07271074 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01309567 0,07254586 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01309567 0,07238173 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01309567 0,07221834 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01309567 0,07205569 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01309567 0,07189376 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01309567 0,07173257 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01309567 0,07157209 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01309567 0,07141233 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01309567 0,07125328 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01309567 0,07109494 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01309567 0,07093731 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01309567 0,07078036 ! forebrain regionalization GO:0021871 9 6 0,000 0,01309567 0,07062412 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01309567 0,07046856 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01309567 0,07031368 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01309567 0,07015948 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01309567 0,07000596 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01309567 0,06985311 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01309567 0,06970093 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01309567 0,0695494 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01309567 0,06939854 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01309567 0,06924832 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01309567 0,06909876 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01309567 0,06894984 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01309567 0,06880156 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01309567 0,06865392 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01309567 0,06850691 ! protein refolding GO:0042026 15 6 0,000 0,01309567 0,06836052 ! opsonization GO:0008228 8 6 0,000 0,01309567 0,06821477 ! mating behavior GO:0007617 7 6 0,000 0,01309567 0,06806963 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01309567 0,06792511 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01309567 0,0677812 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01309567 0,0676379 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01309567 0,0674952 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01309567 0,0673531 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01309567 0,06721161 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01309567 0,0670707 ! toxin metabolic process GO:0009404 11 6 0,000 0,01309567 0,06693039 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01309567 0,06679066 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01309567 0,06665151 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01309567 0,06651294 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01309567 0,06637495 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,01309567 0,06623753 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01309567 0,06610067 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01309567 0,06596438 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01309567 0,06582865 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01309567 0,06569348 ! thymic T cell selection GO:0045061 16 6 0,000 0,01309567 0,06555886 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01309567 0,0654248 ! protein lipoylation GO:0009249 10 6 0,000 0,01309567 0,06529128 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01309567 0,0651583 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01309567 0,06502586 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01309567 0,06489397 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01309567 0,0647626 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01309567 0,06463177 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01309567 0,06450146 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01309567 0,06437168 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01309567 0,06424242 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01309567 0,06411368 ! hyperosmotic response GO:0006972 10 6 0,000 0,01309567 0,06398545 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01309567 0,06385773 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01309567 0,06373053 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01309567 0,06360383 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01309567 0,06347763 ! urea metabolic process GO:0019627 7 6 0,000 0,01309567 0,06335193 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01309567 0,06322673 ! neutrophil activation GO:0042119 7 6 0,000 0,01309567 0,06310202 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01309567 0,0629778 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01309567 0,06285408 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01309567 0,06273083 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01309567 0,06260807 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01309567 0,06248579 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01309567 0,06236399 ! neuron apoptosis GO:0051402 15 6 0,000 0,01309567 0,06224266 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01309567 0,0621218 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01309567 0,0620014 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01309567 0,06188148 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01309567 0,06176202 ! carnitine transport GO:0015879 10 6 0,000 0,01309567 0,06164302 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01309567 0,06152447 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01309567 0,06140638 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01309567 0,06128874 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01309567 0,06117156 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01309567 0,06105482 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01309567 0,06093852 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01309567 0,06082267 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01309567 0,06070726 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01309567 0,06059228 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01309567 0,06047774 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01309567 0,06036363 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01309567 0,06024995 ! response to UV-C GO:0010225 14 6 0,000 0,01309567 0,0601367 ! astrocyte development GO:0014002 16 6 0,000 0,01309567 0,06002387 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01309567 0,05991147 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01309567 0,05979949 ! interaction with symbiont GO:0051702 14 6 0,000 0,01309567 0,05968792 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01309567 0,05957677 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01309567 0,05946603 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01309567 0,0593557 ! response to copper ion GO:0046688 10 6 0,000 0,01309567 0,05924579 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01309567 0,05913628 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01309567 0,05902717 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01309567 0,05891846 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01309567 0,05881016 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01309567 0,05870225 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01309567 0,05859473 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01309567 0,05848761 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01309567 0,05838088 ! hair follicle maturation GO:0048820 8 6 0,000 0,01309567 0,05827454 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01309567 0,05816859 ! Schwann cell development GO:0014044 15 6 0,000 0,01309567 0,05806302 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01309567 0,05795783 ! response to pheromone GO:0019236 6 6 0,000 0,01309567 0,05785303 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01309567 0,0577486 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01309567 0,05764455 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01309567 0,05754087 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01309567 0,05743757 ! subpallium development GO:0021544 15 6 0,000 0,01309567 0,05733463 ! neural tube patterning GO:0021532 8 6 0,000 0,01309567 0,05723207 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01309567 0,05712987 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01309567 0,05702803 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01309567 0,05692656 ! G2 phase GO:0051319 16 6 0,000 0,01309567 0,05682544 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01309567 0,05672469 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01309567 0,05662429 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01309567 0,05652425 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01309567 0,05642456 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01309567 0,05632522 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01309567 0,05622623 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01309567 0,05612759 ! receptor internalization GO:0031623 11 6 0,000 0,01309567 0,05602929 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,01309567 0,05593134 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,01309567 0,05583373 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01309567 0,05573645 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01309567 0,05563952 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01309567 0,05554293 ! protein deubiquitination GO:0016579 16 6 0,000 0,01309567 0,05544666 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,01309567 0,05535074 ! protein destabilization GO:0031648 9 6 0,000 0,01309567 0,05525514 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01309567 0,05515987 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01309567 0,05506493 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01309567 0,05497032 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01309567 0,05487603 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01309567 0,05478206 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01309567 0,05468842 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01309567 0,05459509 GO:0032862|activation of Rho GTPase activity, ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01309567 0,05450209 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01309567 0,0544094 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01309567 0,05431702 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01309567 0,05422496 ! neural plate development GO:0001840 9 6 0,000 0,01309567 0,05413321 ! catecholamine transport GO:0051937 9 6 0,000 0,01309567 0,05404176 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01309567 0,05395063 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01309567 0,05385981 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01309567 0,05376929 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01309567 0,05367907 ! maternal placenta development GO:0001893 12 6 0,000 0,01309567 0,05358915 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01309567 0,05349954 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01309567 0,05341023 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01309567 0,05332121 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01309567 0,05323249 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01309567 0,05314406 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01309567 0,05305593 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01309567 0,05296809 GO:0055081|anion homeostasis, ! protein oligomerization GO:0051259 149 79 1,000 0,01313228 0,05302835 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,01345004 0,05422185 ! response to hypoxia GO:0001666 178 81 1,000 0,01377113 0,05542483 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,01377113 0,05533367 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,01409554 0,05654418 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,01442325 0,05776395 GO:0045937|positive regulation of phosphate metabolic process, ! cellular response to hormone stimulus GO:0032870 182 85 1,000 0,01508852 0,06032938 ! tRNA transcription GO:0009304 17 7 0,000 0,01526176 0,06092236 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,01526176 0,06082298 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,01526176 0,06072392 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01526176 0,06062518 ! regulation of helicase activity GO:0051095 16 7 0,000 0,01526176 0,06052676 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,01526176 0,06042866 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,01526176 0,06033088 ! sleep GO:0030431 16 7 0,000 0,01526176 0,06023342 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01526176 0,06013627 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,01526176 0,06003943 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01526176 0,0599429 ! prostate gland development GO:0030850 14 7 0,000 0,01526176 0,05984669 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,01526176 0,05975078 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01526176 0,05965518 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01526176 0,05955988 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,01526176 0,05946489 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01526176 0,0593702 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,01526176 0,05927581 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01526176 0,05918172 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,01526176 0,05908793 ! glycolipid transport GO:0046836 11 7 0,000 0,01526176 0,05899444 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01526176 0,05890124 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,01526176 0,05880834 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,01526176 0,05871572 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,01526176 0,0586234 ! mRNA stabilization GO:0048255 18 7 0,000 0,01526176 0,05853137 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,01526176 0,05843963 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,01526176 0,05834818 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,01526176 0,05825701 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,01526176 0,05816612 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,01526176 0,05807552 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01526176 0,0579852 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01526176 0,05789516 ! lipoprotein transport GO:0042953 14 7 0,000 0,01526176 0,0578054 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,01526176 0,05771592 ! rhythmic behavior GO:0007622 17 7 0,000 0,01526176 0,05762672 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,01526176 0,05753779 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,01526176 0,05744913 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,01526176 0,05736075 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,01526176 0,05727263 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01526176 0,05718479 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,01526176 0,05709722 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01526176 0,05700992 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,01526176 0,05692288 ! mechanosensory behavior GO:0007638 16 7 0,000 0,01526176 0,0568361 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,01526176 0,0567496 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,01526176 0,05666335 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,01526176 0,05657737 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,01526176 0,05649164 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01526176 0,05640618 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01526176 0,05632097 ! spinal cord patterning GO:0021511 14 7 0,000 0,01526176 0,05623603 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,01526176 0,05615133 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,01526176 0,05606689 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01526176 0,05598271 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,01526176 0,05589878 ! adrenal gland development GO:0030325 17 7 0,000 0,01526176 0,0558151 ! cysteine metabolic process GO:0006534 13 7 0,000 0,01526176 0,05573167 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,01526176 0,05564848 ! ovulation GO:0030728 10 7 0,000 0,01526176 0,05556555 ! adenohypophysis development GO:0021984 11 7 0,000 0,01526176 0,05548286 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,01526176 0,05540042 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,01526176 0,05531823 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,01526176 0,05523627 ! microtubule nucleation GO:0007020 21 7 0,000 0,01526176 0,05515456 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01526176 0,05507309 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,01526176 0,05499187 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01526176 0,05491088 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,01526176 0,05483012 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,01526176 0,05474961 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01526176 0,05466933 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,01526176 0,05458929 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,01526176 0,05450948 ! galactose metabolic process GO:0006012 13 7 0,000 0,01526176 0,0544299 ! vesicle fusion GO:0006906 20 7 0,000 0,01526176 0,05435056 ! response to dietary excess GO:0002021 8 7 0,000 0,01526176 0,05427145 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01526176 0,05419257 ! intracellular pH reduction GO:0051452 13 7 0,000 0,01526176 0,05411391 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01526176 0,05403549 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,01526176 0,05395729 ! organ growth GO:0035265 15 7 0,000 0,01526176 0,05387931 ! nucleoside transport GO:0015858 11 7 0,000 0,01526176 0,05380157 ! nucleoside salvage GO:0043174 11 7 0,000 0,01526176 0,05372404 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,01526176 0,05364674 ! male sex determination GO:0030238 15 7 0,000 0,01526176 0,05356966 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,01526176 0,0534928 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,01526176 0,05341617 ! parturition GO:0007567 16 7 0,000 0,01526176 0,05333975 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,01526176 0,05326355 ! rRNA modification GO:0000154 14 7 0,000 0,01526176 0,05318757 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,01526176 0,0531118 ! spindle checkpoint GO:0031577 16 7 0,000 0,01526176 0,05303625 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,01526176 0,05296092 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,01526176 0,05288579 ! monocyte differentiation GO:0030224 16 7 0,000 0,01526176 0,05281089 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,01526176 0,05273619 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01526176 0,0526617 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,01526176 0,05258743 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,01526176 0,05251336 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,01526176 0,0524395 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01526176 0,05236585 ! fibrinolysis GO:0042730 11 7 0,000 0,01526176 0,05229241 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,01526176 0,05221917 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,01526176 0,05214613 ! eating behavior GO:0042755 8 7 0,000 0,01526176 0,0520733 ! B cell lineage commitment GO:0002326 21 7 0,000 0,01526176 0,05200068 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01526176 0,05192825 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,01526176 0,05185603 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,01526176 0,05178401 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,01526176 0,05171218 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01526176 0,05164056 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,01526176 0,05156914 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,01526176 0,05149791 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,01526176 0,05142688 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,01526176 0,05135604 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01526176 0,0512854 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,01526176 0,05121495 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,01526176 0,0511447 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01526176 0,05107464 ! histone ubiquitination GO:0016574 9 7 0,000 0,01526176 0,05100477 ! regulation of meiosis GO:0040020 12 7 0,000 0,01526176 0,05093509 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,01526176 0,0508656 ! T cell lineage commitment GO:0002360 16 7 0,000 0,01526176 0,0507963 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,01526176 0,05072719 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01526176 0,05065827 ! membrane to membrane docking GO:0022614 14 7 0,000 0,01526176 0,05058953 ! transcription termination GO:0006353 14 7 0,000 0,01526176 0,05052098 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01526176 0,05045262 ! anaphase GO:0051322 18 7 0,000 0,01526176 0,05038444 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,01526176 0,05031644 ! axonal fasciculation GO:0007413 19 7 0,000 0,01526176 0,05024863 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,01526176 0,050181 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,01526176 0,05011355 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,01526176 0,05004629 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,01526176 0,0499792 ! diuresis GO:0030146 12 7 0,000 0,01526176 0,0499123 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01526176 0,04984557 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01526176 0,04977902 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01526176 0,04971265 ! antibiotic transport GO:0042891 9 7 0,000 0,01526176 0,04964645 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01526176 0,04958043 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,01526176 0,04951459 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,01526176 0,04944892 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,01526176 0,04938342 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,01526176 0,0493181 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,01526176 0,04925295 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,01526176 0,04918797 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01526176 0,04912317 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01526176 0,04905853 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,01526176 0,04899407 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,01526176 0,04892977 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,01526176 0,04886564 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,01526176 0,04880168 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,01526176 0,04873789 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,01526176 0,04867426 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,01526176 0,0486108 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,01526176 0,04854751 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,01526176 0,04848438 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01526176 0,04842141 ! muscle adaptation GO:0043500 13 7 0,000 0,01526176 0,04835861 ! embryonic heart tube development GO:0035050 14 7 0,000 0,01526176 0,04829596 ! retina homeostasis GO:0001895 12 7 0,000 0,01526176 0,04823349 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,01526176 0,04817117 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,01526176 0,04810901 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,01526176 0,04804702 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,01526176 0,04798518 ! mitochondrion organization GO:0007005 159 87 1,000 0,0157668 0,04950937 ! regulation of DNA binding GO:0051101 167 89 1,000 0,01645798 0,0516134 ! ossification GO:0001503 205 91 1,000 0,01716192 0,05375202 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,01742316 0,05450036 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,01742316 0,05443066 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,01742316 0,05436115 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,01742316 0,05429181 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,01742316 0,05422265 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,01742316 0,05415366 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,01742316 0,05408485 ! male meiosis GO:0007140 9 8 0,000 0,01742316 0,05401622 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,01742316 0,05394776 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,01742316 0,05387947 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,01742316 0,05381135 ! meiotic prophase I GO:0007128 14 8 0,000 0,01742316 0,05374341 ! response to zinc ion GO:0010043 12 8 0,000 0,01742316 0,05367564 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,01742316 0,05360803 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,01742316 0,0535406 ! oligopeptide transport GO:0006857 16 8 0,000 0,01742316 0,05347334 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,01742316 0,05340625 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,01742316 0,05333932 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,01742316 0,05327256 ! signal peptide processing GO:0006465 12 8 0,000 0,01742316 0,05320597 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,01742316 0,05313955 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,01742316 0,05307329 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,01742316 0,0530072 ! succinate metabolic process GO:0006105 17 8 0,000 0,01742316 0,05294127 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,01742316 0,0528755 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,01742316 0,0528099 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,01742316 0,05274446 ! estrogen metabolic process GO:0008210 17 8 0,000 0,01742316 0,05267918 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,01742316 0,05261407 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,01742316 0,05254911 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,01742316 0,05248431 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,01742316 0,05241968 ! reflex GO:0060004 17 8 0,000 0,01742316 0,0523552 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,01742316 0,05229088 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,01742316 0,05222672 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,01742316 0,05216272 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,01742316 0,05209887 ! pigment granule organization GO:0048753 17 8 0,000 0,01742316 0,05203518 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,01742316 0,05197165 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,01742316 0,05190827 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,01742316 0,05184504 ! astrocyte differentiation GO:0048708 19 8 0,000 0,01742316 0,05178197 ! histidine catabolic process GO:0006548 10 8 0,000 0,01742316 0,05171905 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,01742316 0,05165629 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,01742316 0,05159367 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,01742316 0,05153121 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,01742316 0,0514689 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,01742316 0,05140674 ! melanin metabolic process GO:0006582 17 8 0,000 0,01742316 0,05134473 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,01742316 0,05128287 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,01742316 0,05122115 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,01742316 0,05115959 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,01742316 0,05109817 ! macrophage activation GO:0042116 13 8 0,000 0,01742316 0,05103691 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,01742316 0,05097578 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,01742316 0,05091481 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,01742316 0,05085398 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,01742316 0,05079329 ! purine salvage GO:0043101 12 8 0,000 0,01742316 0,05073275 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,01742316 0,05067236 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01742316 0,0506121 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,01742316 0,05055199 ! osteoblast development GO:0002076 17 8 0,000 0,01742316 0,05049203 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,01742316 0,0504322 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,01742316 0,05037252 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,01742316 0,05031298 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,01742316 0,05025358 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,01742316 0,05019431 ! response to UV-B GO:0010224 17 8 0,000 0,01742316 0,05013519 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,01742316 0,05007621 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,01742316 0,05001737 ! intermediate filament organization GO:0045109 12 8 0,000 0,01742316 0,04995866 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,01742316 0,04990009 ! cellular extravasation GO:0045123 13 8 0,000 0,01742316 0,04984166 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,01742316 0,04978337 ! response to antibiotic GO:0046677 11 8 0,000 0,01742316 0,04972521 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,01742316 0,04966719 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,01742316 0,0496093 ! DNA topological change GO:0006265 12 8 0,000 0,01742316 0,04955155 ! response to tropane GO:0014073 15 8 0,000 0,01742316 0,04949393 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,01742316 0,04943644 ! melanosome transport GO:0032402 13 8 0,000 0,01742316 0,04937909 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,01742316 0,04932188 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,01742316 0,04926479 ! mast cell activation GO:0045576 14 8 0,000 0,01742316 0,04920784 ! multicellular organismal aging GO:0010259 20 8 0,000 0,01742316 0,04915101 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,01742316 0,04909432 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,01742316 0,04903776 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,01742316 0,04898133 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,01742316 0,04892503 ! nucleosome disassembly GO:0006337 14 8 0,000 0,01742316 0,04886886 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,01742316 0,04881282 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,01742316 0,04875691 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,01742316 0,04870112 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,01742316 0,04864546 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,01742316 0,04858993 ! intracellular lipid transport GO:0032365 16 8 0,000 0,01742316 0,04853453 ! response to tumor cell GO:0002347 16 8 0,000 0,01742316 0,04847925 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,01742316 0,04842409 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,01742316 0,04836907 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,01742316 0,04831416 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,01742316 0,04825939 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,01742316 0,04820473 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,01742316 0,0481502 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,01742316 0,0480958 ! hormone catabolic process GO:0042447 17 8 0,000 0,01742316 0,04804151 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,01742316 0,04798735 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,01742316 0,04793331 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,01742316 0,04787939 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,01742316 0,04782559 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,01742316 0,04777192 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,01742316 0,04771836 ! adult feeding behavior GO:0008343 10 8 0,000 0,01742316 0,04766493 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,01742316 0,04761161 ! ATP catabolic process GO:0006200 11 8 0,000 0,01742316 0,04755841 ! blastocyst growth GO:0001832 19 8 0,000 0,01742316 0,04750533 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,01742316 0,04745237 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,01742316 0,04739953 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,01742316 0,04734681 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,01742316 0,0472942 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,01742316 0,04724171 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,01742316 0,04718933 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,01742316 0,04713708 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,01742316 0,04708493 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,01742316 0,0470329 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,01742316 0,04698099 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,01742316 0,04692919 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,01742316 0,04687751 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,01742316 0,04682594 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,01742316 0,04677448 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,01742316 0,04672314 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,01742316 0,04667191 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,01742316 0,04662079 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,01742316 0,04656978 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,01742316 0,04651888 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,01742316 0,0464681 ! bone development GO:0060348 206 92 1,000 0,01751865 0,04667181 ! positive regulation of MAP kinase activity GO:0043406 174 93 1,000 0,01787852 0,04757867 ! axon extension GO:0048675 16 9 0,000 0,01957987 0,05204965 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,01957987 0,05199308 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,01957987 0,05193662 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,01957987 0,05188029 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,01957987 0,05182409 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,01957987 0,051768 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,01957987 0,05171203 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,01957987 0,05165619 ! reproductive behavior GO:0019098 22 9 0,000 0,01957987 0,05160047 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,01957987 0,05154486 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,01957987 0,05148938 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,01957987 0,05143401 ! UTP metabolic process GO:0046051 10 9 0,000 0,01957987 0,05137877 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,01957987 0,05132364 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,01957987 0,05126863 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,01957987 0,05121374 ! artery development GO:0060840 25 9 0,000 0,01957987 0,05115896 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,01957987 0,05110431 ! regulation of glycolysis GO:0006110 20 9 0,000 0,01957987 0,05104977 ! equilibrioception GO:0050957 20 9 0,000 0,01957987 0,05099534 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,01957987 0,05094103 ! chemosensory behavior GO:0007635 21 9 0,000 0,01957987 0,05088684 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,01957987 0,05083276 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,01957987 0,0507788 ! leukocyte degranulation GO:0043299 16 9 0,000 0,01957987 0,05072495 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,01957987 0,05067122 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,01957987 0,0506176 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,01957987 0,05056409 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,01957987 0,0505107 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,01957987 0,05045742 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,01957987 0,05040425 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,01957987 0,05035119 ! protein targeting to ER GO:0045047 25 9 0,000 0,01957987 0,05029825 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,01957987 0,05024541 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,01957987 0,05019269 ! T cell selection GO:0045058 27 9 0,000 0,01957987 0,05014008 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,01957987 0,05008757 ! glycine catabolic process GO:0006546 15 9 0,000 0,01957987 0,05003518 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,01957987 0,0499829 ! endosome organization GO:0007032 20 9 0,000 0,01957987 0,04993072 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,01957987 0,04987866 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,01957987 0,0498267 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,01957987 0,04977485 ! mannose metabolic process GO:0006013 13 9 0,000 0,01957987 0,04972311 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,01957987 0,04967148 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,01957987 0,04961995 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,01957987 0,04956853 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,01957987 0,04951722 ! receptor clustering GO:0043113 20 9 0,000 0,01957987 0,04946601 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,01957987 0,04941491 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,01957987 0,04936391 ! retinol metabolic process GO:0042572 20 9 0,000 0,01957987 0,04931302 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,01957987 0,04926224 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,01957987 0,04921156 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,01957987 0,04916098 ! macrophage differentiation GO:0030225 15 9 0,000 0,01957987 0,0491105 ! oligodendrocyte development GO:0014003 11 9 0,000 0,01957987 0,04906013 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,01957987 0,04900987 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,01957987 0,0489597 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,01957987 0,04890964 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,01957987 0,04885968 ! response to amine stimulus GO:0014075 13 9 0,000 0,01957987 0,04880983 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,01957987 0,04876007 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,01957987 0,04871042 ! erythrocyte development GO:0048821 17 9 0,000 0,01957987 0,04866087 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,01957987 0,04861141 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,01957987 0,04856206 ! renal water homeostasis GO:0003091 15 9 0,000 0,01957987 0,04851281 ! postreplication repair GO:0006301 25 9 0,000 0,01957987 0,04846366 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,01957987 0,04841461 ! icosanoid secretion GO:0032309 15 9 0,000 0,01957987 0,04836565 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,01957987 0,0483168 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,01957987 0,04826804 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,01957987 0,04821939 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,01957987 0,04817083 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,01957987 0,04812237 ! sterol catabolic process GO:0016127 14 9 0,000 0,01957987 0,048074 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,01957987 0,04802573 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,01957987 0,04797756 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,01957987 0,04792949 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,01957987 0,04788151 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,01957987 0,04783363 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,01957987 0,04778585 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,01957987 0,04773816 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,01957987 0,04769056 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,01957987 0,04764306 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,01957987 0,04759565 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,01957987 0,04754834 ! purine base metabolic process GO:0006144 25 9 0,000 0,01957987 0,04750112 ! pigment granule transport GO:0051904 17 9 0,000 0,01957987 0,047454 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,01957987 0,04740697 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,01957987 0,04736003 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,01957987 0,04731319 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,01957987 0,04726643 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,01957987 0,04721977 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,01957987 0,04717321 ! mitochondrion localization GO:0051646 18 9 0,000 0,01957987 0,04712673 ! interphase of mitotic cell cycle GO:0051329 224 98 1,000 0,01972455 0,04742822 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,02048446 0,04920702 GO:0060538|skeletal muscle organ development, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02173191 0,05215233 ! regulation of developmental growth GO:0048638 16 10 0,000 0,02173191 0,05210115 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,02173191 0,05205007 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02173191 0,05199909 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02173191 0,05194821 ! associative learning GO:0008306 21 10 0,000 0,02173191 0,05189743 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,02173191 0,05184675 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02173191 0,05179616 ! phosphate transport GO:0006817 24 10 0,000 0,02173191 0,05174568 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02173191 0,05169529 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02173191 0,05164501 ! CTP metabolic process GO:0046036 11 10 0,000 0,02173191 0,05159482 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02173191 0,05154473 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02173191 0,05149473 ! GTP metabolic process GO:0046039 11 10 0,000 0,02173191 0,05144483 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02173191 0,05139503 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02173191 0,05134533 ! social behavior GO:0035176 29 10 0,000 0,02173191 0,05129572 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02173191 0,0512462 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,02173191 0,05119679 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02173191 0,05114746 ! androgen metabolic process GO:0008209 17 10 0,000 0,02173191 0,05109824 ! phospholipid efflux GO:0033700 19 10 0,000 0,02173191 0,0510491 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02173191 0,05100006 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02173191 0,05095112 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02173191 0,05090227 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02173191 0,05085351 ! lung alveolus development GO:0048286 26 10 0,000 0,02173191 0,05080485 ! pathogenesis GO:0009405 17 10 0,000 0,02173191 0,05075628 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02173191 0,0507078 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02173191 0,05065942 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02173191 0,05061112 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,02173191 0,05056292 ! endoderm development GO:0007492 18 10 0,000 0,02173191 0,05051481 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02173191 0,05046679 ! arginine catabolic process GO:0006527 17 10 0,000 0,02173191 0,05041887 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02173191 0,05037103 ! proline metabolic process GO:0006560 13 10 0,000 0,02173191 0,05032329 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02173191 0,05027563 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02173191 0,05022807 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02173191 0,05018059 ! V(D)J recombination GO:0033151 34 10 0,000 0,02173191 0,05013321 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02173191 0,05008591 ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02173191 0,05003871 ! B cell proliferation GO:0042100 19 10 0,000 0,02173191 0,04999159 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02173191 0,04994456 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02173191 0,04989762 ! multicellular organism growth GO:0035264 19 10 0,000 0,02173191 0,04985077 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02173191 0,049804 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02173191 0,04975733 ! ruffle organization GO:0031529 17 10 0,000 0,02173191 0,04971074 ! epithelial cell development GO:0002064 21 10 0,000 0,02173191 0,04966424 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02173191 0,04961782 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02173191 0,04957149 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02173191 0,04952525 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02173191 0,04947909 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02173191 0,04943302 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02173191 0,04938704 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,02173191 0,04934114 ! motor axon guidance GO:0008045 22 10 0,000 0,02173191 0,04929533 ! copper ion homeostasis GO:0055070 13 10 0,000 0,02173191 0,0492496 ! regulation of bone resorption GO:0045124 25 10 0,000 0,02173191 0,04920395 ! protein heterooligomerization GO:0051291 17 10 0,000 0,02173191 0,0491584 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02173191 0,04911292 GO:0045685|regulation of glial cell differentiation, ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02173191 0,04906753 ! segment specification GO:0007379 15 10 0,000 0,02173191 0,04902222 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02173191 0,048977 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02173191 0,04893186 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02173191 0,0488868 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02173191 0,04884183 ! response to dsRNA GO:0043331 23 10 0,000 0,02173191 0,04879694 ! DNA ligation GO:0006266 18 10 0,000 0,02173191 0,04875213 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02173191 0,0487074 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02173191 0,04866276 ! melanosome localization GO:0032400 16 10 0,000 0,02173191 0,04861819 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02173191 0,04857371 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02173191 0,04852931 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,02173191 0,04848499 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02173191 0,04844075 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,02173191 0,0483966 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02173191 0,04835252 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02173191 0,04830852 ! protein sumoylation GO:0016925 17 10 0,000 0,02173191 0,04826461 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02173191 0,04822077 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02173191 0,04817701 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02173191 0,04813333 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02173191 0,04808973 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02173191 0,04804621 ! salivary gland development GO:0007431 28 10 0,000 0,02173191 0,04800277 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02173191 0,04795941 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02173191 0,04791613 ! midbrain development GO:0030901 14 10 0,000 0,02173191 0,04787292 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02173191 0,04782979 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02173191 0,04778674 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02173191 0,04774377 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02173191 0,04770087 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02173191 0,04765805 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02173191 0,04761531 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02173191 0,04757264 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02173191 0,04753005 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02173191 0,04748754 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,02173191 0,0474451 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,02173191 0,04740274 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02173191 0,04736045 ! blastocyst formation GO:0001825 18 10 0,000 0,02173191 0,04731824 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02173191 0,04727611 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02173191 0,04723405 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02173191 0,04719206 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02173191 0,04715015 ! response to nicotine GO:0035094 20 10 0,000 0,02173191 0,04710831 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02173191 0,04706655 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,02173191 0,04702486 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,02387929 0,05162576 ! respiratory burst GO:0045730 17 11 0,000 0,02387929 0,05158012 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,02387929 0,05153455 ! neuron fate specification GO:0048665 18 11 0,000 0,02387929 0,05148906 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,02387929 0,05144366 ! thyroid gland development GO:0030878 26 11 0,000 0,02387929 0,05139834 ! synapsis GO:0007129 14 11 0,000 0,02387929 0,05135309 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,02387929 0,05130792 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,02387929 0,05126284 ! response to pain GO:0048265 27 11 0,000 0,02387929 0,05121783 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,02387929 0,0511729 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,02387929 0,05112805 ! blood vessel remodeling GO:0001974 30 11 0,000 0,02387929 0,05108328 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,02387929 0,05103859 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,02387929 0,05099398 ! bone resorption GO:0045453 16 11 0,000 0,02387929 0,05094944 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,02387929 0,05090498 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,02387929 0,0508606 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,02387929 0,0508163 ! melanocyte differentiation GO:0030318 20 11 0,000 0,02387929 0,05077207 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,02387929 0,05072792 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,02387929 0,05068385 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,02387929 0,05063985 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,02387929 0,05059593 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,02387929 0,05055209 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,02387929 0,05050832 ! UV protection GO:0009650 20 11 0,000 0,02387929 0,05046463 ! adult heart development GO:0007512 16 11 0,000 0,02387929 0,05042101 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,02387929 0,05037747 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,02387929 0,050334 ! macroautophagy GO:0016236 19 11 0,000 0,02387929 0,05029061 ! temperature homeostasis GO:0001659 18 11 0,000 0,02387929 0,0502473 ! behavioral fear response GO:0001662 27 11 0,000 0,02387929 0,05020405 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,02387929 0,05016089 ! negative regulation of ossification GO:0030279 27 11 0,000 0,02387929 0,05011779 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,02387929 0,05007477 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,02387929 0,05003183 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,02387929 0,04998895 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,02387929 0,04994616 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,02387929 0,04990343 ! regulation of organ growth GO:0046620 14 11 0,000 0,02387929 0,04986078 ! pigment granule localization GO:0051875 20 11 0,000 0,02387929 0,0498182 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,02387929 0,04977569 ! vasoconstriction GO:0042310 20 11 0,000 0,02387929 0,04973326 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,02387929 0,04969089 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,02387929 0,0496486 ! embryonic axis specification GO:0000578 19 11 0,000 0,02387929 0,04960639 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,02387929 0,04956424 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,02387929 0,04952217 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,02387929 0,04948016 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,02387929 0,04943823 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,02387929 0,04939637 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,02387929 0,04935458 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,02387929 0,04931286 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,02387929 0,04927121 ! prophase GO:0051324 17 11 0,000 0,02387929 0,04922963 ! nucleosome positioning GO:0016584 15 11 0,000 0,02387929 0,04918812 ! regulation of isotype switching GO:0045191 24 11 0,000 0,02387929 0,04914668 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,02387929 0,04910531 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,02387929 0,04906401 ! apical protein localization GO:0045176 18 11 0,000 0,02387929 0,04902278 ! acid secretion GO:0046717 20 11 0,000 0,02387929 0,04898162 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,02387929 0,04894053 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,02387929 0,04889951 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,02387929 0,04885855 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,02387929 0,04881767 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,02387929 0,04877685 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,02387929 0,0487361 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,02387929 0,04869542 ! cholesterol efflux GO:0033344 21 11 0,000 0,02387929 0,0486548 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,02387929 0,04861426 ! oocyte development GO:0048599 20 11 0,000 0,02387929 0,04857378 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,02387929 0,04853337 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,02387929 0,04849303 ! embryonic gut development GO:0048566 19 11 0,000 0,02387929 0,04845275 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,02387929 0,04841254 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,02387929 0,0483724 ! activation of innate immune response GO:0002218 16 11 0,000 0,02387929 0,04833232 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,02387929 0,04829231 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,02387929 0,04825237 ! lysogeny GO:0030069 22 11 0,000 0,02387929 0,04821249 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,02387929 0,04817268 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,02387929 0,04813293 ! sequestering of metal ion GO:0051238 15 11 0,000 0,02387929 0,04809325 ! regulation of embryonic development GO:0045995 35 11 0,000 0,02387929 0,04805363 ! nucleus localization GO:0051647 22 11 0,000 0,02387929 0,04801408 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,02602202 0,05227943 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,02602202 0,05223647 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,02602202 0,05219358 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,02602202 0,05215077 ! virus-host interaction GO:0019048 30 12 0,000 0,02602202 0,05210802 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,02602202 0,05206534 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,02602202 0,05202274 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,02602202 0,0519802 ! protein complex disassembly GO:0043241 28 12 0,000 0,02602202 0,05193773 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,02602202 0,05189533 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,02602202 0,05185301 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,02602202 0,05181075 ! T cell proliferation GO:0042098 32 12 0,000 0,02602202 0,05176855 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,02602202 0,05172643 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,02602202 0,05168438 ! ventral spinal cord development GO:0021517 25 12 0,000 0,02602202 0,05164239 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,02602202 0,05160048 ! drug transport GO:0015893 16 12 0,000 0,02602202 0,05155863 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,02602202 0,05151684 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,02602202 0,05147513 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,02602202 0,05143348 ! polyamine metabolic process GO:0006595 18 12 0,000 0,02602202 0,0513919 ! focal adhesion formation GO:0048041 37 12 0,000 0,02602202 0,05135039 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,02602202 0,05130895 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,02602202 0,05126757 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 21 12 0,000 0,02602202 0,05122626 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,02602202 0,05118501 ! entry into host cell GO:0030260 34 12 0,000 0,02602202 0,05114383 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02602202 0,05110272 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,02602202 0,05106167 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,02602202 0,05102069 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,02602202 0,05097978 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,02602202 0,05093893 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,02602202 0,05089815 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,02602202 0,05085743 ! snRNA metabolic process GO:0016073 30 12 0,000 0,02602202 0,05081677 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,02602202 0,05077619 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,02602202 0,05073566 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,02602202 0,0506952 ! cranial nerve development GO:0021545 23 12 0,000 0,02602202 0,05065481 ! fucose catabolic process GO:0019317 25 12 0,000 0,02602202 0,05061448 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,02602202 0,05057421 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,02602202 0,05053401 ! autonomic nervous system development GO:0048483 24 12 0,000 0,02602202 0,05049387 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,02602202 0,0504538 ! zymogen activation GO:0031638 18 12 0,000 0,02602202 0,05041379 ! T cell homeostasis GO:0043029 28 12 0,000 0,02602202 0,05037384 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,02602202 0,05033396 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,02602202 0,05029413 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,02602202 0,05025438 ! oocyte differentiation GO:0009994 21 12 0,000 0,02602202 0,05021468 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,02602202 0,05017505 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,02602202 0,05013548 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,02602202 0,05009597 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,02602202 0,05005652 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,02602202 0,05001714 ! defense response to fungus GO:0050832 15 12 0,000 0,02602202 0,04997782 ! embryonic placenta development GO:0001892 21 12 0,000 0,02602202 0,04993856 ! lamellipodium assembly GO:0030032 24 12 0,000 0,02602202 0,04989936 ! response to cold GO:0009409 17 12 0,000 0,02602202 0,04986022 ! establishment of cell polarity GO:0030010 21 12 0,000 0,02602202 0,04982115 ! regulation of synapse organization GO:0050807 18 12 0,000 0,02602202 0,04978213 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,0281601 0,05383029 ! cGMP metabolic process GO:0046068 18 13 0,000 0,0281601 0,05378821 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,0281601 0,05374618 ! regulation of chemokine production GO:0032642 18 13 0,000 0,0281601 0,05370423 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,0281601 0,05366234 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,0281601 0,05362051 ! peroxisomal transport GO:0043574 28 13 0,000 0,0281601 0,05357875 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,0281601 0,05353706 ! cartilage condensation GO:0001502 22 13 0,000 0,0281601 0,05349542 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,0281601 0,05345386 ! organelle fusion GO:0048284 36 13 0,000 0,0281601 0,05341236 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,0281601 0,05337092 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,0281601 0,05332955 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,0281601 0,05328824 ! endocrine pancreas development GO:0031018 25 13 0,000 0,0281601 0,05324699 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,0281601 0,05320581 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,0281601 0,0531647 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,0281601 0,05312364 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,0281601 0,05308265 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,0281601 0,05304172 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,0281601 0,05300086 ! methionine metabolic process GO:0006555 31 13 0,000 0,0281601 0,05296006 ! plasma membrane organization GO:0007009 27 13 0,000 0,0281601 0,05291932 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,0281601 0,05287864 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,0281601 0,05283803 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,0281601 0,05279748 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,0281601 0,05275699 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,0281601 0,05271656 ! cytokine metabolic process GO:0042107 24 13 0,000 0,0281601 0,0526762 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,0281601 0,0526359 ! exocrine system development GO:0035272 34 13 0,000 0,0281601 0,05259565 ! asymmetric protein localization GO:0008105 24 13 0,000 0,0281601 0,05255547 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,0281601 0,05251536 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,0281601 0,0524753 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,0281601 0,0524353 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,0281601 0,05239537 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,0281601 0,05235549 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,0281601 0,05231568 ! protein homotetramerization GO:0051289 24 13 0,000 0,0281601 0,05227592 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,0281601 0,05223623 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,0281601 0,0521966 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,0281601 0,05215703 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,0281601 0,05211751 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,0281601 0,05207806 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,0281601 0,05203867 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,0281601 0,05199933 ! histone methylation GO:0016571 29 13 0,000 0,0281601 0,05196006 ! chromatin silencing GO:0006342 29 13 0,000 0,0281601 0,05192084 ! gland morphogenesis GO:0022612 31 13 0,000 0,0281601 0,05188169 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,0281601 0,05184259 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,0281601 0,05180355 ! regulation of epidermis development GO:0045682 19 13 0,000 0,0281601 0,05176457 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,0281601 0,05172565 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,0281601 0,05168679 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,0281601 0,05164799 ! spleen development GO:0048536 24 13 0,000 0,0281601 0,05160924 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,0281601 0,05157055 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,0281601 0,05153192 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,0281601 0,05149335 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,0281601 0,05145484 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,0281601 0,05141638 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,0281601 0,05137798 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,0281601 0,05133964 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,0281601 0,05130135 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,0281601 0,05126313 ! insulin secretion GO:0030073 24 13 0,000 0,0281601 0,05122496 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,0281601 0,05118684 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,0281601 0,05114879 ! acrosome reaction GO:0007340 19 13 0,000 0,0281601 0,05111078 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,0281601 0,05107284 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,0281601 0,05103495 ! rRNA transcription GO:0009303 28 14 0,000 0,03029354 0,05486073 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,03029354 0,05482009 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,03029354 0,05477952 ! water transport GO:0006833 21 14 0,000 0,03029354 0,054739 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,03029354 0,05469854 ! non-recombinational repair GO:0000726 29 14 0,000 0,03029354 0,05465814 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,03029354 0,05461781 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,03029354 0,05457753 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,03029354 0,05453731 ! RNA polyadenylation GO:0043631 32 14 0,000 0,03029354 0,05449715 ! lipid localization GO:0010876 32 14 0,000 0,03029354 0,05445705 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,03029354 0,05441701 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,03029354 0,05437702 ! regulated secretory pathway GO:0045055 24 14 0,000 0,03029354 0,0543371 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,03029354 0,05429723 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,03029354 0,05425743 ! arginine metabolic process GO:0006525 21 14 0,000 0,03029354 0,05421768 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,03029354 0,05417799 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,03029354 0,05413835 ! regulation of heart rate GO:0002027 25 14 0,000 0,03029354 0,05409878 ! fear response GO:0042596 34 14 0,000 0,03029354 0,05405926 ! organic alcohol transport GO:0015850 29 14 0,000 0,03029354 0,0540198 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,03029354 0,0539804 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,03029354 0,05394106 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,03029354 0,05390177 ! neutral amino acid transport GO:0015804 28 14 0,000 0,03029354 0,05386254 ! bone mineralization GO:0030282 18 14 0,000 0,03029354 0,05382337 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,03029354 0,05378425 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,03029354 0,05374519 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,03029354 0,05370619 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,03029354 0,05366724 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,03029354 0,05362835 ! regulation of cellular pH GO:0030641 27 14 0,000 0,03029354 0,05358952 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,03029354 0,05355074 ! ribosome assembly GO:0042255 18 14 0,000 0,03029354 0,05351202 ! cerebellum development GO:0021549 23 14 0,000 0,03029354 0,05347336 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,03029354 0,05343475 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,03029354 0,0533962 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,03029354 0,0533577 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,03029354 0,05331926 ! NADP metabolic process GO:0006739 24 14 0,000 0,03029354 0,05328087 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,03029354 0,05324254 ! oxygen transport GO:0015671 22 14 0,000 0,03029354 0,05320426 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,03029354 0,05316604 ! male genitalia development GO:0030539 26 14 0,000 0,03029354 0,05312787 ! regulation of RNA stability GO:0043487 33 14 0,000 0,03029354 0,05308976 ! regulation of axon extension GO:0030516 43 14 0,000 0,03029354 0,0530517 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,03029354 0,0530137 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,03029354 0,05297575 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,03242237 0,05665797 ! lactation GO:0007595 30 15 0,000 0,03242237 0,05661747 ! reproductive cellular process GO:0048610 22 15 0,000 0,03242237 0,05657703 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,03242237 0,05653665 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,03242237 0,05649632 ! superoxide anion generation GO:0042554 22 15 0,000 0,03242237 0,05645605 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,03242237 0,05641584 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,03242237 0,05637569 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,03242237 0,05633559 ! copper ion transport GO:0006825 22 15 0,000 0,03242237 0,05629555 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,03242237 0,05625557 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,03242237 0,05621565 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,03242237 0,05617578 ! sulfate transport GO:0008272 27 15 0,000 0,03242237 0,05613596 ! response to cAMP GO:0051591 25 15 0,000 0,03242237 0,05609621 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,03242237 0,05605651 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,03242237 0,05601686 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,03242237 0,05597727 ! response to hexose stimulus GO:0009746 25 15 0,000 0,03242237 0,05593774 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,03242237 0,05589827 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,03242237 0,05585885 ! vesicle coating GO:0006901 38 15 0,000 0,03242237 0,05581948 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,03242237 0,05578017 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,03242237 0,05574092 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,03242237 0,05570172 ! regulation of exocytosis GO:0017157 26 15 0,000 0,03242237 0,05566257 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,03242237 0,05562349 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,03242237 0,05558445 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,03242237 0,05554547 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,03242237 0,05550655 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,03242237 0,05546768 ! regulation of vasodilation GO:0042312 27 15 0,000 0,03242237 0,05542886 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,03242237 0,0553901 ! histone deacetylation GO:0016575 24 15 0,000 0,03242237 0,05535139 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,03242237 0,05531274 ! water homeostasis GO:0030104 28 15 0,000 0,03242237 0,05527414 ! cofactor transport GO:0051181 30 15 0,000 0,03242237 0,0552356 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,03242237 0,0551971 ! muscle maintenance GO:0046716 26 15 0,000 0,03242237 0,05515867 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,03242237 0,05512028 ! intestinal absorption GO:0050892 31 15 0,000 0,03242237 0,05508195 ! dopamine metabolic process GO:0042417 35 15 0,000 0,03242237 0,05504367 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,03242237 0,05500545 ! heme biosynthetic process GO:0006783 33 15 0,000 0,03242237 0,05496728 ! cell killing GO:0001906 32 15 0,000 0,03242237 0,05492916 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,03242237 0,05489109 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,03242237 0,05485308 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,03242237 0,05481512 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,03242237 0,05477721 ! actin filament polymerization GO:0030041 27 15 0,000 0,03242237 0,05473935 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,03242237 0,05470155 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,03454658 0,0582452 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,03454658 0,05820503 ! positive regulation of cell size GO:0045793 29 16 0,000 0,03454658 0,05816491 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,03454658 0,05812485 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,03454658 0,05808485 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,03454658 0,0580449 ! bone remodeling GO:0046849 28 16 0,000 0,03454658 0,05800501 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,03454658 0,05796517 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,03454658 0,05792539 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,03454658 0,05788566 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,03454658 0,05784598 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,03454658 0,05780636 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,03454658 0,0577668 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,03454658 0,05772728 ! startle response GO:0001964 28 16 0,000 0,03454658 0,05768783 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,03454658 0,05764842 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,03454658 0,05760907 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,03454658 0,05756977 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,03454658 0,05753053 ! protein polyubiquitination GO:0000209 41 16 0,000 0,03454658 0,05749134 ! glutamate metabolic process GO:0006536 25 16 0,000 0,03454658 0,0574522 ! pituitary gland development GO:0021983 30 16 0,000 0,03454658 0,05741312 ! response to osmotic stress GO:0006970 27 16 0,000 0,03454658 0,05737409 ! lysosomal transport GO:0007041 31 16 0,000 0,03454658 0,05733511 ! fructose metabolic process GO:0006000 25 16 0,000 0,03454658 0,05729619 ! L-amino acid transport GO:0015807 33 16 0,000 0,03454658 0,05725732 ! stem cell development GO:0048864 46 16 0,000 0,03454658 0,0572185 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,03454658 0,05717974 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,03454658 0,05714102 ! intermediate filament-based process GO:0045103 36 16 0,000 0,03454658 0,05710236 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,03454658 0,05706375 ! negative regulation of immune response GO:0050777 38 16 0,000 0,03454658 0,0570252 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,03454658 0,05698669 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,03454658 0,05694824 ! DNA replication initiation GO:0006270 28 16 0,000 0,03454658 0,05690984 ! mRNA splice site selection GO:0006376 44 16 0,000 0,03454658 0,05687149 ! tissue regeneration GO:0042246 27 16 0,000 0,03454658 0,05683319 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,03454658 0,05679495 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,03454658 0,05675675 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,03454658 0,05671861 ! biomineral formation GO:0031214 22 16 0,000 0,03454658 0,05668052 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,03454658 0,05664248 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,03454658 0,05660449 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,03454658 0,05656655 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,03454658 0,05652866 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,03454658 0,05649082 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,03454658 0,05645304 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,03454658 0,0564153 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,03454658 0,05637761 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,03454658 0,05633998 ! peptide hormone processing GO:0016486 27 16 0,000 0,03454658 0,05630239 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,03666618 0,05971699 ! metencephalon development GO:0022037 32 17 0,000 0,03666618 0,05967721 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,03666618 0,05963747 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,03666618 0,0595978 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,03666618 0,05955817 ! signal complex assembly GO:0007172 47 17 0,000 0,03666618 0,0595186 ! filopodium assembly GO:0046847 42 17 0,000 0,03666618 0,05947907 ! endothelial cell migration GO:0043542 31 17 0,000 0,03666618 0,05943961 ! gene silencing by RNA GO:0031047 38 17 0,000 0,03666618 0,05940019 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,03666618 0,05936083 ! glial cell development GO:0021782 28 17 0,000 0,03666618 0,05932151 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,03666618 0,05928225 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,03666618 0,05924305 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,03666618 0,05920389 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,03666618 0,05916479 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,03666618 0,05912573 ! myoblast differentiation GO:0045445 50 17 0,000 0,03666618 0,05908673 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,03666618 0,05904778 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,03666618 0,05900888 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,03666618 0,05897004 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,03666618 0,05893124 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,03666618 0,0588925 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,03666618 0,0588538 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,03666618 0,05881516 ! NAD metabolic process GO:0019674 33 17 0,000 0,03666618 0,05877657 ! membrane budding GO:0006900 42 17 0,000 0,03666618 0,05873802 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,03666618 0,05869953 ! regulation of protein binding GO:0043393 33 17 0,000 0,03666618 0,05866109 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,03666618 0,0586227 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,03666618 0,05858436 ! genitalia development GO:0048806 32 17 0,000 0,03666618 0,05854607 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,03666618 0,05850783 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,03666618 0,05846964 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,03666618 0,0584315 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,03666618 0,05839341 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,03666618 0,05835537 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,03666618 0,05831737 ! steroid catabolic process GO:0006706 34 17 0,000 0,03666618 0,05827943 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,03666618 0,05824154 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,03666618 0,0582037 ! gas transport GO:0015669 26 17 0,000 0,03666618 0,0581659 ! organic cation transport GO:0015695 32 17 0,000 0,03666618 0,05812815 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,03666618 0,05809046 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,03666618 0,05805281 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,03666618 0,05801521 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,0387812 0,06132198 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,0387812 0,06128232 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,0387812 0,0612427 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,0387812 0,06120314 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,0387812 0,06116363 ! adult walking behavior GO:0007628 36 18 0,000 0,0387812 0,06112417 ! patterning of blood vessels GO:0001569 43 18 0,000 0,0387812 0,06108476 ! heart looping GO:0001947 34 18 0,000 0,0387812 0,0610454 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,0387812 0,06100609 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,0387812 0,06096683 ! centrosome cycle GO:0007098 26 18 0,000 0,0387812 0,06092763 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,0387812 0,06088847 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,0387812 0,06084937 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,0387812 0,06081031 ! glycine metabolic process GO:0006544 30 18 0,000 0,0387812 0,0607713 ! glutamine metabolic process GO:0006541 29 18 0,000 0,0387812 0,06073235 ! response to retinoic acid GO:0032526 31 18 0,000 0,0387812 0,06069344 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,0387812 0,06065458 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,0387812 0,06061578 ! DNA integration GO:0015074 32 18 0,000 0,0387812 0,06057702 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,0387812 0,06053831 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,0387812 0,06049966 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,0387812 0,06046105 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,0387812 0,06042249 ! neural crest cell migration GO:0001755 41 18 0,000 0,0387812 0,06038398 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,0387812 0,06034552 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,0387812 0,0603071 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,0387812 0,06026874 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,0387812 0,06023043 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,0387812 0,06019216 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,0387812 0,06015394 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,0387812 0,06011578 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,0387812 0,06007765 ! detection of bacterium GO:0016045 22 18 0,000 0,0387812 0,06003958 ! nerve development GO:0021675 34 18 0,000 0,0387812 0,06000156 ! defense response to virus GO:0051607 43 18 0,000 0,0387812 0,05996358 ! microspike assembly GO:0030035 46 18 0,000 0,0387812 0,05992566 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,0387812 0,05988778 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,04089162 0,06310691 ! positive regulation of translation GO:0045727 31 19 0,000 0,04089162 0,06306707 ! negative regulation of defense response GO:0031348 27 19 0,000 0,04089162 0,06302728 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,04089162 0,06298754 ! neuron maturation GO:0042551 46 19 0,000 0,04089162 0,06294785 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,04089162 0,06290821 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,04089162 0,06286862 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,04089162 0,06282908 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,04089162 0,06278959 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,04089162 0,06275015 ! inositol metabolic process GO:0006020 33 19 0,000 0,04089162 0,06271076 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,04089162 0,06267142 ! memory GO:0007613 34 19 0,000 0,04089162 0,06263212 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,04089162 0,06259288 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,04089162 0,06255369 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,04089162 0,06251454 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,04089162 0,06247545 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,04089162 0,0624364 ! pigmentation during development GO:0048066 42 19 0,000 0,04089162 0,0623974 ! response to vitamin A GO:0033189 32 19 0,000 0,04089162 0,06235845 ! heme metabolic process GO:0042168 40 19 0,000 0,04089162 0,06231955 ! neuromuscular junction development GO:0007528 43 19 0,000 0,04089162 0,0622807 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,04089162 0,06224189 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,04089162 0,06220314 ! response to fungus GO:0009620 26 19 0,000 0,04089162 0,06216443 ! peptide cross-linking GO:0018149 39 19 0,000 0,04089162 0,06212577 ! heart process GO:0003015 32 19 0,000 0,04089162 0,06208716 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,04089162 0,06204859 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,04089162 0,06201008 ! visual learning GO:0008542 38 19 0,000 0,04089162 0,06197161 ! cellular pigmentation GO:0033059 37 19 0,000 0,04089162 0,06193319 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,04089162 0,06189482 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,04089162 0,06185649 ! vitamin transport GO:0051180 31 19 0,000 0,04089162 0,06181822 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,04089162 0,06177999 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,04089162 0,0617418 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,04089162 0,06170367 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,04089162 0,06166558 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,04089162 0,06162754 ! cilium assembly GO:0042384 38 19 0,000 0,04089162 0,06158954 ! peptide hormone secretion GO:0030072 32 19 0,000 0,04089162 0,06155159 ! protein secretion GO:0009306 45 20 0,000 0,04299748 0,06468155 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,04299748 0,06464175 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,04299748 0,06460199 ! positive regulation of ossification GO:0045778 50 20 0,000 0,04299748 0,06456229 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,04299748 0,06452263 ! skin development GO:0043588 42 20 0,000 0,04299748 0,06448302 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,04299748 0,06444346 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,04299748 0,06440395 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,04299748 0,06436448 ! response to vitamin GO:0033273 36 20 0,000 0,04299748 0,06432507 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,04299748 0,0642857 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,04299748 0,06424638 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,04299748 0,06420711 ! bile acid metabolic process GO:0008206 34 20 0,000 0,04299748 0,06416789 ! response to alkaloid GO:0043279 38 20 0,000 0,04299748 0,06412872 ! retinoid metabolic process GO:0001523 34 20 0,000 0,04299748 0,06408959 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,04299748 0,06405051 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,04299748 0,06401148 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,04299748 0,0639725 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,04299748 0,06393356 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 0,000 0,04299748 0,06389467 ! body fluid secretion GO:0007589 33 20 0,000 0,04299748 0,06385583 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,04299748 0,06381703 ! peptide secretion GO:0002790 38 20 0,000 0,04299748 0,06377829 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,04299748 0,06373959 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,04299748 0,06370093 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,04299748 0,06366233 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,04299748 0,06362377 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,04299748 0,06358525 ! cell-cell junction organization GO:0045216 43 20 0,000 0,04299748 0,06354679 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,04299748 0,06350837 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,04299748 0,06346999 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,04299748 0,06343167 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,04299748 0,06339338 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,04299748 0,06335515 ! regulation of glucose import GO:0046324 30 20 0,000 0,04299748 0,06331696 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,04299748 0,06327882 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,04299748 0,06324072 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,04299748 0,06320267 ! negative regulation of translation GO:0017148 32 20 0,000 0,04299748 0,06316466 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,04299748 0,06312671 ! regulation of cell killing GO:0031341 46 21 0,000 0,04509877 0,06617194 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,04509877 0,06613223 ! hormone secretion GO:0046879 39 21 0,000 0,04509877 0,06609255 ! cAMP metabolic process GO:0046058 41 21 0,000 0,04509877 0,06605293 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,04509877 0,06601335 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,04509877 0,06597382 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,04509877 0,06593434 ! ovarian follicle development GO:0001541 39 21 0,000 0,04509877 0,06589491 ! smooth muscle contraction GO:0006939 48 21 0,000 0,04509877 0,06585552 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,04509877 0,06581618 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,04509877 0,06577689 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,04509877 0,06573764 ! plasma membrane fusion GO:0045026 33 21 0,000 0,04509877 0,06569844 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,04509877 0,06565929 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,04509877 0,06562018 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,04509877 0,06558112 ! sensory perception of pain GO:0019233 33 21 0,000 0,04509877 0,06554211 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,04509877 0,06550314 ! diencephalon development GO:0021536 36 21 0,000 0,04509877 0,06546422 ! collagen fibril organization GO:0030199 62 21 0,000 0,04509877 0,06542535 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,04509877 0,06538652 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,04509877 0,06534774 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,04509877 0,065309 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,04509877 0,06527031 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,04509877 0,06523167 ! collagen catabolic process GO:0030574 29 21 0,000 0,04509877 0,06519307 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,04509877 0,06515452 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,04509877 0,06511601 ! sperm-egg recognition GO:0035036 23 21 0,000 0,04509877 0,06507755 ! actin filament-based movement GO:0030048 47 21 0,000 0,04509877 0,06503913 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,04509877 0,06500076 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,0471955 0,06798267 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,0471955 0,06794261 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,0471955 0,0679026 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,0471955 0,06786263 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,0471955 0,06782271 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,0471955 0,06778284 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,0471955 0,06774301 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,0471955 0,06770324 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,0471955 0,0676635 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,0471955 0,06762382 ! cellular response to starvation GO:0009267 37 22 0,000 0,0471955 0,06758418 ! vacuolar transport GO:0007034 41 22 0,000 0,0471955 0,06754459 ! fucose metabolic process GO:0006004 44 22 0,000 0,0471955 0,06750504 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,0471955 0,06746554 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,0471955 0,06742609 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,0471955 0,06738668 ! ureteric bud development GO:0001657 50 22 0,000 0,0471955 0,06734732 ! cell aging GO:0007569 48 22 0,000 0,0471955 0,067308 ! stem cell differentiation GO:0048863 57 22 0,000 0,0471955 0,06726873 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,0471955 0,06722951 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,0471955 0,06719033 ! cytolysis GO:0019835 27 22 0,000 0,0471955 0,0671512 ! renal system process GO:0003014 42 22 0,000 0,0471955 0,06711211 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,0471955 0,06707307 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,0471955 0,06703408 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 0,0471955 0,06699512 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,0471955 0,06695622 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,0471955 0,06691736 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,0471955 0,06687854 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,0471955 0,06683977 ! sarcomere organization GO:0045214 32 22 0,000 0,0471955 0,06680105 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,0471955 0,06676237 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,0471955 0,06672373 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,0471955 0,06668514 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,0471955 0,0666466 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,0471955 0,06660809 ! gut development GO:0048565 44 22 0,000 0,0471955 0,06656964 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,0471955 0,06653122 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,0471955 0,06649285 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,0471955 0,06645453 ! protein stabilization GO:0050821 41 22 0,000 0,0471955 0,06641625 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,04928769 0,06932057 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,04928769 0,06928068 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,04928769 0,06924084 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,04928769 0,06920105 ! gluconeogenesis GO:0006094 38 23 0,000 0,04928769 0,0691613 ! glycerol metabolic process GO:0006071 40 23 0,000 0,04928769 0,0691216 ! viral genome replication GO:0019079 44 23 0,000 0,04928769 0,06908194 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,04928769 0,06904233 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,04928769 0,06900277 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,04928769 0,06896325 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,04928769 0,06892377 ! regeneration GO:0031099 42 23 0,000 0,04928769 0,06888434 ! axis specification GO:0009798 43 23 0,000 0,04928769 0,06884496 ! visual behavior GO:0007632 46 23 0,000 0,04928769 0,06880562 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,04928769 0,06876632 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,04928769 0,06872707 ! response to ethanol GO:0045471 47 23 0,000 0,04928769 0,06868787 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,04928769 0,0686487 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,04928769 0,06860959 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,04928769 0,06857052 ! peroxisome organization GO:0007031 43 23 0,000 0,04928769 0,06853149 ! lysosome organization GO:0007040 47 23 0,000 0,04928769 0,06849251 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,04928769 0,06845357 ! vesicle targeting GO:0006903 49 23 0,000 0,04928769 0,06841468 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,04928769 0,06837583 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,04928769 0,06833702 GO:0060415|muscle tissue morphogenesis, ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,04928769 0,06829826 ! DNA modification GO:0006304 36 23 0,000 0,04928769 0,06825954 ! fatty acid transport GO:0015908 47 23 0,000 0,04928769 0,06822087 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,04928769 0,06818224 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,04928769 0,06814365 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,04928769 0,06810511 ! hormone transport GO:0009914 41 23 0,000 0,04928769 0,06806661 ! cell-cell recognition GO:0009988 28 23 0,000 0,04928769 0,06802815 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,04928769 0,06798974 ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,04928769 0,06795137 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,05137534 0,0707896 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,05137534 0,0707497 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,05137534 0,07070984 ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,05137534 0,07067003 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,05137534 0,07063026 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,05137534 0,07059053 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,05137534 0,07055085 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,05137534 0,07051122 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,05137534 0,07047163 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,05137534 0,07043208 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,05137534 0,07039258 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,05137534 0,07035312 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,05137534 0,07031371 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,05137534 0,07027434 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,05137534 0,07023501 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,05137534 0,07019573 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,05137534 0,07015649 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,05137534 0,0701173 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,05137534 0,07007815 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 52 24 0,000 0,05137534 0,07003904 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,05137534 0,06999998 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,05137534 0,06996096 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,05137534 0,06992199 ! membrane depolarization GO:0051899 45 24 0,000 0,05137534 0,06988306 ! oogenesis GO:0048477 44 24 0,000 0,05137534 0,06984417 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,05137534 0,06980532 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,05137534 0,06976652 ! platelet activation GO:0030168 41 24 0,000 0,05137534 0,06972776 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,05137534 0,06968904 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,05137534 0,06965037 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,05137534 0,06961174 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,05137534 0,06957315 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,05137534 0,06953461 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,05137534 0,06949611 ! regulation of amine transport GO:0051952 41 24 0,000 0,05137534 0,06945765 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,05345847 0,07223399 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,05345847 0,07219406 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,05345847 0,07215417 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,05345847 0,07211433 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,05345847 0,07207453 ! leukocyte adhesion GO:0007159 55 25 0,000 0,05345847 0,07203478 ! phototransduction GO:0007602 37 25 0,000 0,05345847 0,07199507 ! keratinization GO:0031424 37 25 0,000 0,05345847 0,0719554 ! vasculogenesis GO:0001570 49 25 0,000 0,05345847 0,07191578 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,05345847 0,0718762 ! vacuole organization GO:0007033 49 25 0,000 0,05345847 0,07183666 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,05345847 0,07179717 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,05345847 0,07175772 ! receptor metabolic process GO:0043112 53 25 0,000 0,05345847 0,07171831 ! chromosome condensation GO:0030261 48 25 0,000 0,05345847 0,07167895 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,05345847 0,07163963 ! regulation of behavior GO:0050795 48 25 0,000 0,05345847 0,07160036 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,05345847 0,07156112 ! interaction with host GO:0051701 66 25 0,000 0,05345847 0,07152193 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,05345847 0,07148279 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,05345847 0,07144368 ! immunoglobulin production GO:0002377 62 25 0,000 0,05345847 0,07140462 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,05345847 0,0713656 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,05345847 0,07132662 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,05345847 0,07128769 ! liver development GO:0001889 55 25 0,000 0,05345847 0,0712488 ! protein tetramerization GO:0051262 57 25 0,000 0,05345847 0,07120995 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,05553709 0,07393847 ! myelination GO:0042552 50 26 0,000 0,05553709 0,0738982 ! initiation of viral infection GO:0019059 60 26 0,000 0,05553709 0,07385798 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,05553709 0,07381779 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,05553709 0,07377765 ! molting cycle process GO:0022404 52 26 0,000 0,05553709 0,07373755 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,05553709 0,0736975 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,05553709 0,07365749 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,05553709 0,07361753 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,05553709 0,0735776 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,05553709 0,07353772 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,05553709 0,07349789 ! digestive system process GO:0022600 49 26 0,000 0,05553709 0,07345809 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,05553709 0,07341834 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,05553709 0,07337864 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 0,000 0,05553709 0,07333897 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,05553709 0,07329935 ! osteoblast differentiation GO:0001649 63 26 0,000 0,05553709 0,07325977 ! neural crest cell development GO:0014032 59 26 0,000 0,05553709 0,07322024 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 83 26 0,000 0,05553709 0,07318074 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,05553709 0,07314129 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,05553709 0,07310189 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,05553709 0,07306252 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,05553709 0,0730232 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,05553709 0,07298392 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,05553709 0,07294468 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,05553709 0,07290548 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,05553709 0,07286633 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,05553709 0,07282721 ! blastocyst development GO:0001824 50 26 0,000 0,05553709 0,07278814 ! telomere organization GO:0032200 46 26 0,000 0,05553709 0,07274912 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,05553709 0,07271013 ! neural tube closure GO:0001843 58 26 0,000 0,05553709 0,07267118 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,05553709 0,07263228 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,05553709 0,07259342 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,05553709 0,0725546 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,05761119 0,07522402 ! embryonic pattern specification GO:0009880 49 27 0,000 0,05761119 0,07518384 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,05761119 0,0751437 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,05761119 0,0751036 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,05761119 0,07506354 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,05761119 0,07502353 ! iron ion transport GO:0006826 65 27 0,000 0,05761119 0,07498356 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,05761119 0,07494363 ! tube lumen formation GO:0035148 59 27 0,000 0,05761119 0,07490375 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,05761119 0,07486391 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,05761119 0,07482411 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,05761119 0,07478435 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,05761119 0,07474463 ! response to starvation GO:0042594 47 27 0,000 0,05761119 0,07470496 ! response to toxin GO:0009636 49 27 0,000 0,05761119 0,07466533 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,05761119 0,07462574 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,05761119 0,07458619 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,05761119 0,07454669 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,05761119 0,07450722 ! leukocyte proliferation GO:0070661 59 27 0,000 0,05761119 0,0744678 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,05761119 0,07442842 ! regulation of fibroblast proliferation GO:0048145 56 28 0,000 0,0596808 0,07706142 ! neuron fate commitment GO:0048663 52 28 0,000 0,0596808 0,07702071 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,0596808 0,07698004 ! vesicle docking GO:0048278 55 28 0,000 0,0596808 0,07693942 ! circadian rhythm GO:0007623 56 28 0,000 0,0596808 0,07689884 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,0596808 0,0768583 ! fat cell differentiation GO:0045444 57 28 0,000 0,0596808 0,07681781 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,0596808 0,07677736 ! sperm motility GO:0030317 37 28 0,000 0,0596808 0,07673695 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,0596808 0,07669658 ! base-excision repair GO:0006284 41 28 0,000 0,0596808 0,07665626 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,0596808 0,07661597 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,0596808 0,07657573 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,0596808 0,07653554 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,0596808 0,07649538 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,0596808 0,07645527 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,0596808 0,0764152 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,0596808 0,07637517 ! lipid oxidation GO:0034440 48 28 0,000 0,0596808 0,07633518 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,0596808 0,07629524 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,0596808 0,07625533 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,06174592 0,07885274 ! translational initiation GO:0006413 66 29 0,000 0,06174592 0,07881154 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,06174592 0,07877039 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,06174592 0,07872928 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,06174592 0,07868821 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,06174592 0,07864718 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,06174592 0,0786062 ! primary neural tube formation GO:0014020 61 29 0,000 0,06174592 0,07856526 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,06174592 0,07852436 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,06174592 0,0784835 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,06174592 0,07844269 ! synaptogenesis GO:0007416 46 29 0,000 0,06174592 0,07840192 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,06174592 0,07836119 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,06380657 0,08093429 ! phenol metabolic process GO:0018958 56 30 0,000 0,06380657 0,08089229 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,06380657 0,08085034 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,06380657 0,08080842 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,06380657 0,08076655 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,06380657 0,08072473 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,06380657 0,08068294 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,06380657 0,08064121 ! acute-phase response GO:0006953 50 30 0,000 0,06380657 0,08059951 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,06380657 0,08055786 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,06380657 0,08051624 ! myofibril assembly GO:0030239 50 30 0,000 0,06380657 0,08047468 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,06380657 0,08043315 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,06380657 0,08039167 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,06380657 0,08035023 ! cell fate determination GO:0001709 64 30 0,000 0,06380657 0,08030884 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,06380657 0,08026748 ! phospholipid transport GO:0015914 65 30 0,000 0,06380657 0,08022617 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,06380657 0,0801849 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,06380657 0,08014368 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,06380657 0,08010249 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,06380657 0,08006135 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,06380657 0,08002025 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,06380657 0,07997919 ! regulation of coagulation GO:0050818 52 30 0,000 0,06380657 0,07993818 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,06586275 0,08247191 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,06586275 0,08242966 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,06586275 0,08238745 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,06586275 0,08234529 ! cell junction assembly GO:0034329 85 31 0,000 0,06586275 0,08230317 ! regulation of innate immune response GO:0045088 57 31 0,000 0,06586275 0,08226109 ! ovulation cycle process GO:0022602 55 31 0,000 0,06586275 0,08221906 ! peptide transport GO:0015833 60 31 0,000 0,06586275 0,08217706 ! male gonad development GO:0008584 56 31 0,000 0,06586275 0,08213512 ! iron ion homeostasis GO:0055072 60 31 0,000 0,06586275 0,08209321 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,06586275 0,08205135 ! detection of light stimulus GO:0009583 44 31 0,000 0,06586275 0,08200953 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,06586275 0,08196775 ! natural killer cell activation GO:0030101 50 31 0,000 0,06586275 0,08192601 ! ensheathment of neurons GO:0007272 64 31 0,000 0,06586275 0,08188432 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,06586275 0,08184267 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,06586275 0,08180106 ! eye morphogenesis GO:0048592 65 31 0,000 0,06586275 0,0817595 ! response to heat GO:0009408 54 31 0,000 0,06586275 0,08171797 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,06586275 0,08167649 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,06791447 0,0841781 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,06791447 0,08413542 ! collagen metabolic process GO:0032963 49 32 0,000 0,06791447 0,08409277 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,06791447 0,08405017 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,06791447 0,08400762 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,06791447 0,0839651 ! metanephros development GO:0001656 81 32 0,000 0,06791447 0,08392263 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,06791447 0,0838802 ! muscle cell development GO:0055001 52 32 0,000 0,06791447 0,08383782 ! mesoderm formation GO:0001707 73 32 0,000 0,06791447 0,08379548 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,06791447 0,08375318 ! ovulation cycle GO:0042698 57 32 0,000 0,06791447 0,08371092 ! peripheral nervous system development GO:0007422 68 32 0,000 0,06791447 0,0836687 ! BMP signaling pathway GO:0030509 71 32 0,000 0,06791447 0,08362653 ! hindbrain development GO:0030902 65 32 0,000 0,06791447 0,0835844 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,06791447 0,08354232 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,06791447 0,08350027 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,06791447 0,08345827 ! gene silencing GO:0016458 71 32 0,000 0,06791447 0,08341631 ! regulation of pH GO:0006885 56 33 0,000 0,06996174 0,0858877 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,06996174 0,08584456 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,06996174 0,08580147 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,06996174 0,08575842 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,06996174 0,08571541 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,06996174 0,08567244 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,06996174 0,08562952 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,06996174 0,08558664 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,06996174 0,08554381 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,06996174 0,08550101 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,06996174 0,08545826 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,06996174 0,08541555 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,06996174 0,08537289 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,06996174 0,08533027 ! glial cell differentiation GO:0010001 67 34 0,000 0,07200457 0,08777802 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,07200457 0,08773424 ! cholesterol transport GO:0030301 62 34 0,000 0,07200457 0,08769051 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,07200457 0,08764682 ! spliceosome assembly GO:0000245 75 34 0,000 0,07200457 0,08760317 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,07200457 0,08755956 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,07200457 0,087516 ! formation of primary germ layer GO:0001704 76 34 0,000 0,07200457 0,08747248 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,07200457 0,08742901 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,07200457 0,08738557 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,07200457 0,08734218 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,07404297 0,08977021 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,07404297 0,08972568 ! negative regulation of secretion GO:0051048 68 35 0,000 0,07404297 0,0896812 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,07404297 0,08963676 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,07404297 0,08959236 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,07404297 0,08954801 ! membrane docking GO:0022406 69 35 0,000 0,07404297 0,0895037 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,07404297 0,08945943 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,07404297 0,08941521 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,07404297 0,08937104 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,07404297 0,0893269 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,07404297 0,08928281 ! ceramide metabolic process GO:0006672 72 35 0,000 0,07404297 0,08923876 ! sterol transport GO:0015918 63 35 0,000 0,07404297 0,08919476 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,07404297 0,0891508 ! placenta development GO:0001890 53 35 0,000 0,07404297 0,08910688 ! vesicle localization GO:0051648 70 35 0,000 0,07404297 0,08906301 ! regulation of muscle development GO:0048634 82 36 0,000 0,07607695 0,09146456 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,07607695 0,09141957 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,07607695 0,09137463 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,07607695 0,09132973 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,07607695 0,09128487 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,07607695 0,09124006 ! positive regulation of cell development GO:0010720 85 36 0,000 0,07607695 0,09119529 ! protein targeting to membrane GO:0006612 75 36 0,000 0,07607695 0,09115056 ! regulation of proteolysis GO:0030162 77 36 0,000 0,07607695 0,09110588 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,07607695 0,09106124 ! cytokine production GO:0001816 68 36 0,000 0,07607695 0,09101665 ! embryonic organ development GO:0048568 67 36 0,000 0,07607695 0,0909721 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,07607695 0,09092759 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,07607695 0,09088313 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,07810652 0,09326209 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,07810652 0,09321653 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,07810652 0,09317101 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,07810652 0,09312554 ! sister chromatid segregation GO:0000819 65 37 0,000 0,07810652 0,09308011 ! odontogenesis GO:0042476 74 37 0,000 0,07810652 0,09303473 ! actomyosin structure organization GO:0031032 68 37 0,000 0,07810652 0,09298939 ! cell junction organization GO:0034330 96 37 0,000 0,07810652 0,0929441 ! tissue remodeling GO:0048771 78 37 0,000 0,07810652 0,09289885 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,07810652 0,09285364 ! female gonad development GO:0008585 71 37 0,000 0,07810652 0,09280848 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,07810652 0,09276336 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,07810652 0,09271829 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,08013169 0,09507612 ! meiosis I GO:0007127 74 38 0,000 0,08013169 0,09502996 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,08013169 0,09498385 ! organic anion transport GO:0015711 82 38 0,000 0,08013169 0,09493779 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,08013169 0,09489177 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,08013169 0,0948458 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,08013169 0,09479987 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,08013169 0,09475398 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,08013169 0,09470814 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,08013169 0,09466234 ! regulation of protein stability GO:0031647 77 38 0,000 0,08013169 0,09461659 ! pigment metabolic process GO:0042440 87 38 0,000 0,08013169 0,09457088 ! neural tube formation GO:0001841 79 38 0,000 0,08013169 0,09452522 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,08215247 0,0968622 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,08215247 0,09681548 ! negative regulation of binding GO:0051100 71 39 0,000 0,08215247 0,0967688 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,08215247 0,09672216 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,08215247 0,09667557 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,08215247 0,09662902 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,08215247 0,09658252 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,08215247 0,09653607 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,08215247 0,09648965 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,08215247 0,09644329 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,08215247 0,09639697 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,08416886 0,09871557 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,08416886 0,0986682 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,08416886 0,09862088 ! learning GO:0007612 82 40 0,000 0,08416886 0,0985736 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,08416886 0,09852637 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,08416886 0,09847918 ! lipid homeostasis GO:0055088 75 40 0,000 0,08416886 0,09843204 ! mismatch repair GO:0006298 58 40 0,000 0,08416886 0,09838495 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,08416886 0,09833789 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,08416886 0,09829089 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,08416886 0,09824393 ! mRNA catabolic process GO:0006402 79 41 0,000 0,08618089 0,10054437 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,08618089 0,10049637 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,08618089 0,10044843 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,08618089 0,10040053 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,08618089 0,10035267 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,08618089 0,10030486 ! gliogenesis GO:0042063 91 41 0,000 0,08618089 0,1002571 ! feeding behavior GO:0007631 69 41 0,000 0,08618089 0,10020938 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,08618089 0,10016171 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,08618089 0,10011408 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,08618089 0,10006649 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,08618089 0,10001896 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,08618089 0,09997146 ! RNA modification GO:0009451 64 41 0,000 0,08618089 0,09992402 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,08818854 0,10220333 ! ear morphogenesis GO:0042471 64 42 0,000 0,08818854 0,10215487 ! organic ether metabolic process GO:0018904 59 42 0,000 0,08818854 0,10210645 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,08818854 0,10205808 ! T cell differentiation GO:0030217 93 42 0,000 0,08818854 0,10200976 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,08818854 0,10196148 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,08818854 0,10191325 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,08818854 0,10186507 ! regulation of protein secretion GO:0050708 77 42 0,000 0,08818854 0,10181693 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,08818854 0,10176883 ! cytokinesis GO:0000910 84 42 0,000 0,08818854 0,10172078 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,08818854 0,10167278 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,09019185 0,10393334 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,09019185 0,10388434 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,09019185 0,10383538 ! glucose transport GO:0015758 66 43 0,000 0,09019185 0,10378647 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,09019185 0,10373761 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,09019185 0,10368879 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,09019185 0,10364002 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,09019185 0,1035913 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,09019185 0,10354262 ! ion transmembrane transport GO:0034220 79 43 0,000 0,09019185 0,10349398 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,09019185 0,10344539 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,09219081 0,10568848 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,09219081 0,1056389 ! hexose transport GO:0008645 68 44 0,000 0,09219081 0,10558938 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,09219081 0,1055399 ! striated muscle contraction GO:0006941 85 44 0,000 0,09219081 0,10549046 ! phagocytosis GO:0006909 105 44 0,000 0,09219081 0,10544108 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,09219081 0,10539174 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,09418543 0,10762161 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,09418543 0,1075713 ! induction of apoptosis by intracellular signals GO:0008629 95 45 0,000 0,09418543 0,10752103 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,09418543 0,10747081 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,09418543 0,10742064 ! biopolymer methylation GO:0043414 91 45 0,000 0,09418543 0,10737051 ! B cell differentiation GO:0030183 124 45 0,000 0,09418543 0,10732043 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,09418543 0,1072704 ! female gamete generation GO:0007292 71 45 0,000 0,09418543 0,10722041 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,09418543 0,10717047 ! polyol metabolic process GO:0019751 77 45 0,000 0,09418543 0,10712058 ! developmental growth GO:0048589 88 45 0,000 0,09418543 0,10707073 ! maintenance of location in cell GO:0051651 101 45 0,000 0,09418543 0,10702093 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,09617573 0,10923166 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,09617573 0,1091809 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,09617573 0,10913019 ! leukocyte migration GO:0050900 75 46 0,000 0,09617573 0,10907953 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,09617573 0,10902891 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,09617573 0,10897834 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,09617573 0,10892782 ! pigmentation GO:0043473 103 46 0,000 0,09617573 0,10887734 ! neural tube development GO:0021915 91 47 0,000 0,09816171 0,11107413 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,09816171 0,11102271 ! positive regulation of defense response GO:0031349 88 48 0,000 0,10014338 0,1132116 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,10014338 0,11315924 ! mitochondrial transport GO:0006839 94 48 0,000 0,10014338 0,11310692 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,10014338 0,11305465 ! cellular component disassembly GO:0022411 89 48 0,000 0,10014338 0,11300243 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,10014338 0,11295026 ! endosome transport GO:0016197 127 48 0,000 0,10014338 0,11289814 ! male sex differentiation GO:0046661 93 48 0,000 0,10014338 0,11284607 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,10014338 0,11279404 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,10014338 0,11274206 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,10014338 0,11269013 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,10014338 0,11263825 ! methylation GO:0032259 97 48 0,000 0,10014338 0,11258641 ! response to calcium ion GO:0051592 94 49 0,000 0,10212075 0,11475667 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,10212075 0,1147039 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,10212075 0,11465119 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,10212075 0,11459853 ! JNK cascade GO:0007254 106 49 0,000 0,10212075 0,11454591 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,10212075 0,11449334 ! regulation of action potential GO:0001508 102 50 0,000 0,10409383 0,11665194 ! regulation of ion transport GO:0043269 86 50 0,000 0,10409383 0,11659846 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,10409383 0,11654502 ! endocrine system development GO:0035270 109 50 0,000 0,10409383 0,11649163 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,10409383 0,11643829 ! activation of caspase activity GO:0006919 95 50 0,000 0,10409383 0,116385 ! regulation of ossification GO:0030278 123 50 0,000 0,10409383 0,11633176 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,10409383 0,11627857 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,10409383 0,11622543 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,10409383 0,11617233 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,10409383 0,11611928 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,10409383 0,11606629 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,10606264 0,11820758 ! viral infectious cycle GO:0019058 104 51 0,000 0,10606264 0,11815368 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,10606264 0,11809983 ! response to temperature stimulus GO:0009266 84 51 0,000 0,10606264 0,11804602 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,10606264 0,11799227 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,10606264 0,11793856 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,10802717 0,12006841 ! Notch signaling pathway GO:0007219 111 52 0,000 0,10802717 0,12001381 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,10802717 0,11995926 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,10802717 0,11990476 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,10802717 0,1198503 ! excretion GO:0007588 87 52 0,000 0,10802717 0,1197959 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,10802717 0,11974155 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,10802717 0,11968724 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,10802717 0,11963299 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,10802717 0,11957878 ! amino acid activation GO:0043038 98 52 0,000 0,10802717 0,11952462 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! positive regulation of growth GO:0045927 96 53 0,000 0,10998744 0,12163844 ! inner ear development GO:0048839 89 53 0,000 0,10998744 0,1215834 ! chromatin remodeling GO:0006338 122 53 0,000 0,10998744 0,12152841 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,10998744 0,12147347 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,10998744 0,12141858 ! vesicle organization GO:0016050 127 53 0,000 0,10998744 0,12136373 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,10998744 0,12130894 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cartilage development GO:0051216 99 53 0,000 0,10998744 0,1212542 ! synapse organization GO:0050808 102 53 0,000 0,10998744 0,12119951 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,11194345 0,1232993 ! regulation of translational initiation GO:0006446 87 54 0,000 0,11194345 0,12324374 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,11194345 0,12318822 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,11194345 0,12313276 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,11194345 0,12307734 ! membrane fusion GO:0006944 122 54 0,000 0,11194345 0,12302198 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,11194345 0,12296666 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,11194345 0,1229114 ! regulation of cell shape GO:0008360 142 54 0,000 0,11194345 0,12285618 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,11194345 0,12280101 ! RNA catabolic process GO:0006401 103 55 0,000 0,11389523 0,12488601 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,11389523 0,12482998 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,11389523 0,12477401 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,11389523 0,12471808 ! cell maturation GO:0048469 107 55 0,000 0,11389523 0,1246622 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,11389523 0,12460638 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,11389523 0,1245506 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,11584276 0,12662366 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,11584276 0,12656703 ! regulation of DNA replication GO:0006275 105 56 0,000 0,11584276 0,12651045 ! RNA elongation GO:0006354 90 56 0,000 0,11584276 0,12645392 ! chloride transport GO:0006821 102 57 0,000 0,11778608 0,12851781 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,11778608 0,12846044 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,11778608 0,12840312 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 0,000 0,11778608 0,12834584 ! heart morphogenesis GO:0003007 105 57 0,000 0,11778608 0,12828862 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,11778608 0,12823145 ! regulation of actin filament length GO:0030832 118 58 0,000 0,11972517 0,13028445 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,11972517 0,13022644 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,11972517 0,13016849 ! gastrulation GO:0007369 122 58 0,000 0,11972517 0,13011058 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,11972517 0,13005273 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,11972517 0,12999493 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,11972517 0,12993718 ! maintenance of location GO:0051235 124 58 0,000 0,11972517 0,12987948 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,12359075 0,1340134 ! DNA catabolic process GO:0006308 94 60 0,000 0,12359075 0,13395395 ! regulation of endocytosis GO:0030100 104 60 0,000 0,12359075 0,13389455 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,12359075 0,13383519 ! kidney development GO:0001822 133 60 0,000 0,12359075 0,1337759 ! positive regulation of secretion GO:0051047 110 61 0,000 0,12551725 0,13580099 ! regulation of cellular component size GO:0032535 125 61 0,000 0,12551725 0,13574088 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,12551725 0,13568081 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,12551725 0,1356208 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,12551725 0,13556085 ! regulation of heart contraction GO:0008016 123 61 0,000 0,12551725 0,13550094 ! camera-type eye development GO:0043010 126 61 0,000 0,12551725 0,13544109 ! proton transport GO:0015992 117 61 0,000 0,12551725 0,1353813 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,12551725 0,13532155 ! viral reproductive process GO:0022415 132 62 0,000 0,12743957 0,13733342 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,12743957 0,13727287 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,12743957 0,13721237 ! tRNA processing GO:0008033 102 62 0,000 0,12743957 0,13715192 ! regulation of homeostatic process GO:0032844 148 62 0,000 0,12743957 0,13709153 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,12935772 0,13909371 ! regulation of mitosis GO:0007088 112 63 0,000 0,12935772 0,13903251 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,12935772 0,13897137 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,12935772 0,13891029 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,12935772 0,13884925 ! hydrogen transport GO:0006818 121 64 0,000 0,1312717 0,14084179 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,1312717 0,14077997 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,1312717 0,14071819 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,13318153 0,14270284 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,13318153 0,14264028 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,13318153 0,14257777 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,13318153 0,14251532 ! ear development GO:0043583 114 66 0,000 0,13508722 0,14449128 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,13508722 0,14442804 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,13508722 0,14436486 ! gonad development GO:0008406 115 66 0,000 0,13508722 0,14430174 ! negative regulation of cell growth GO:0030308 142 67 0,000 0,13698877 0,14626904 ! activation of MAPK activity GO:0000187 124 67 0,000 0,13698877 0,14620514 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,13698877 0,14614129 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,13698877 0,1460775 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,13698877 0,14601377 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,13698877 0,14595009 ! secondary metabolic process GO:0019748 125 67 0,000 0,13698877 0,14588647 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,13698877 0,1458229 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,13888619 0,14777829 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,13888619 0,14771396 ! extracellular matrix organization GO:0030198 146 68 0,000 0,13888619 0,14764968 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,13888619 0,14758546 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,13888619 0,14752129 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,13888619 0,14745718 ! viral reproduction GO:0016032 142 68 0,000 0,13888619 0,14739312 ! adaptive immune response GO:0002250 126 68 0,000 0,13888619 0,14732912 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,13888619 0,14726518 ! cell projection assembly GO:0030031 138 68 0,000 0,13888619 0,14720129 ! negative regulation of cell size GO:0045792 144 69 0,000 0,1407795 0,14914324 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,1407795 0,14907859 ! negative regulation of protein kinase activity GO:0006469 144 69 0,000 0,1407795 0,149014 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,1407795 0,14894946 ! urogenital system development GO:0001655 149 69 0,000 0,1407795 0,14888498 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,1407795 0,14882056 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,1407795 0,14875619 ! developmental maturation GO:0021700 128 69 0,000 0,1407795 0,14869188 ! single fertilization GO:0007338 83 69 0,000 0,1407795 0,14862762 ! negative regulation of kinase activity GO:0033673 145 70 0,000 0,14266869 0,15055707 ! cell redox homeostasis GO:0045454 114 70 0,000 0,14266869 0,15049206 ! activation of immune response GO:0002253 120 70 0,000 0,14266869 0,15042711 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,14266869 0,15036221 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,14455379 0,15228327 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,14455379 0,15221763 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,14455379 0,15215205 ! appendage morphogenesis GO:0035107 150 72 0,000 0,14643479 0,15406554 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,14643479 0,15399922 ! actin filament organization GO:0007015 167 72 0,000 0,14643479 0,15393295 ! B cell activation GO:0042113 179 72 0,000 0,14643479 0,15386675 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,14643479 0,1538006 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,14643479 0,1537345 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,14643479 0,15366847 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,14643479 0,15360248 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,14643479 0,15353656 ! appendage development GO:0048736 151 73 0,000 0,14831171 0,1554378 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,14831171 0,15537114 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,14831171 0,15530454 ! regulation of immune effector process GO:0002697 156 73 0,000 0,14831171 0,155238 ! acute inflammatory response GO:0002526 118 74 0,000 0,15018455 0,15713099 ! amino acid transport GO:0006865 148 74 0,000 0,15018455 0,15706372 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,15018455 0,15699652 ! negative regulation of transferase activity GO:0051348 155 74 0,000 0,15018455 0,15692937 ! transition metal ion transport GO:0000041 143 75 0,000 0,15205333 0,15881415 ! reproductive structure development GO:0048608 131 75 0,000 0,15205333 0,15874628 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,15205333 0,15867847 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,15205333 0,15861071 ! eye development GO:0001654 155 75 0,000 0,15205333 0,15854302 ! axon guidance GO:0007411 162 75 0,000 0,15205333 0,15847538 ! rhythmic process GO:0048511 142 75 0,000 0,15205333 0,1584078 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,15391805 0,1602821 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,15391805 0,16021381 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,15391805 0,16014557 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,15391805 0,1600774 ! amine catabolic process GO:0009310 136 77 0,000 0,15577873 0,16194359 ! neurotransmitter transport GO:0006836 142 77 0,000 0,15577873 0,16187471 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,15577873 0,16180588 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,15577873 0,16173712 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,15577873 0,16166841 ! regulation of catabolic process GO:0009894 173 77 0,000 0,15577873 0,16159976 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,15763536 0,16345636 ! antigen processing and presentation GO:0019882 117 78 0,000 0,15763536 0,16338701 ! fertilization GO:0009566 99 78 0,000 0,15763536 0,16331772 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,15763536 0,16324849 ! blood coagulation GO:0007596 151 79 0,000 0,15948797 0,16509708 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,15948797 0,16502715 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,15948797 0,16495728 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,15948797 0,16488747 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,15948797 0,16481773 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,15948797 0,16474803 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,16133655 0,16658715 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,16133655 0,16651677 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,16133655 0,16644645 ! meiosis GO:0007126 143 81 0,000 0,16318112 0,16827837 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 0,000 0,16318112 0,16820737 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,16318112 0,16813643 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,16502168 0,1699612 ! protein import into nucleus GO:0006606 174 82 0,000 0,16502168 0,16988957 ! meiotic cell cycle GO:0051321 144 82 0,000 0,16502168 0,16981801 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,16685824 0,17163566 ! exocytosis GO:0006887 153 83 0,000 0,16685824 0,17156342 ! response to drug GO:0042493 149 83 0,000 0,16685824 0,17149125 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,16685824 0,17141913 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,16685824 0,17134707 ! nuclear import GO:0051170 177 83 0,000 0,16685824 0,17127508 ! inorganic anion transport GO:0015698 156 83 0,000 0,16685824 0,17120315 ! response to metal ion GO:0010038 158 84 0,000 0,16869082 0,17301078 ! T cell activation GO:0042110 189 84 0,000 0,16869082 0,17293818 ! response to nutrient GO:0007584 135 84 0,000 0,16869082 0,17286564 ! digestion GO:0007586 130 84 0,000 0,16869082 0,17279316 ! regulation of ligase activity GO:0051340 147 84 0,000 0,16869082 0,17272074 ! hemostasis GO:0007599 165 85 0,000 0,17051942 0,17451988 ! negative regulation of transport GO:0051051 164 85 0,000 0,17051942 0,1744468 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,17051942 0,17437377 ! negative regulation of growth GO:0045926 168 85 0,000 0,17051942 0,17430081 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,17051942 0,17422792 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,17051942 0,17415508 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,17051942 0,1740823 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,17234405 0,17587156 ! regulation of lyase activity GO:0051339 169 86 0,000 0,17234405 0,17579813 ! positive regulation of cell activation GO:0050867 161 86 0,000 0,17234405 0,17572476 GO:0002696|positive regulation of leukocyte activation, ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,17416472 0,17750705 ! nucleosome assembly GO:0006334 126 87 0,000 0,17416472 0,17743303 ! amine biosynthetic process GO:0009309 146 88 0,000 0,17598143 0,1792091 ! sensory perception of smell GO:0007608 117 88 0,000 0,17598143 0,17913443 ! chromatin assembly GO:0031497 128 88 0,000 0,17598143 0,17905982 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,17598143 0,17898527 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,17779419 0,18075373 ! tube morphogenesis GO:0035239 194 89 0,000 0,17779419 0,18067854 ! cellular defense response GO:0006968 123 89 0,000 0,17779419 0,18060342 ! protein localization in nucleus GO:0034504 192 89 0,000 0,17779419 0,18052835 ! regulation of neurological system process GO:0031644 175 89 0,000 0,17779419 0,18045335 ! response to inorganic substance GO:0010035 173 90 0,000 0,17960302 0,18221353 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,17960302 0,18213789 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,17960302 0,18206232 ! response to unfolded protein GO:0006986 139 90 0,000 0,17960302 0,1819868 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,17960302 0,18191135 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,18140792 0,18366331 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! gland development GO:0048732 220 91 0,000 0,18140792 0,18358722 ! defense response to bacterium GO:0042742 112 91 0,000 0,18140792 0,1835112 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,18320891 0,18525636 ! regulation of cell adhesion GO:0030155 241 92 0,000 0,18320891 0,18517971 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,18500597 0,18691877 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,18500597 0,1868415 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,18500597 0,1867643 ! vitamin metabolic process GO:0006766 153 93 0,000 0,18500597 0,18668715 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,18679914 0,18841879 ! female pregnancy GO:0007565 166 94 0,000 0,18679914 0,18834102 ! sterol metabolic process GO:0016125 166 94 0,000 0,18679914 0,18826333 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,18679914 0,18818569 ! regulation of membrane potential GO:0042391 179 94 0,000 0,18679914 0,18810812 ! regulation of defense response GO:0031347 171 95 0,000 0,18858841 0,18983168 ! nucleosome organization GO:0034728 143 95 0,000 0,18858841 0,1897535 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,18858841 0,18967538 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,18858841 0,18959732 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,18858841 0,18951933 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,18858841 0,1894414 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,18858841 0,18936354 ! sex differentiation GO:0007548 171 96 0,000 0,1903738 0,19107773 ! response to protein stimulus GO:0051789 158 96 0,000 0,1903738 0,19099926 ! regulation of T cell activation GO:0050863 175 96 0,000 0,1903738 0,19092085 ! regulation of DNA metabolic process GO:0051052 188 97 0,000 0,1921553 0,1926284 ! transcription initiation GO:0006352 171 97 0,000 0,1921553 0,19254939 ! leukocyte differentiation GO:0002521 232 98 0,000 0,19393294 0,19425099 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,19393294 0,19417138 ! mRNA transport GO:0051028 185 100 0,000 0,19747664 0,19763844 ! positive regulation of immune response GO:0050778 175 100 0,000 0,19747664 0,1975575 ! hormone metabolic process GO:0042445 171 100 0,000 0,19747664 0,19747664