pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1289-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 5,000 8,208E-15 2,005E-11 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 3,000 4,296E-08 5,248E-05 ! positive regulation of vasoconstriction GO:0045907 10 5 2,000 4,562E-08 3,715E-05 ! myoblast cell fate commitment GO:0048625 18 6 2,000 9,112E-08 5,565E-05 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 2,000 1,593E-07 7,782E-05 ! positive regulation of microtubule polymerization GO:0031116 15 7 2,000 1,593E-07 6,485E-05 ! positive regulation of insulin secretion GO:0032024 17 8 2,000 2,545E-07 8,883E-05 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 2,545E-07 7,773E-05 ! gas homeostasis GO:0033483 14 8 2,000 2,545E-07 6,909E-05 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 2,000 2,545E-07 6,218E-05 ! regulation of microtubule polymerization GO:0031113 17 8 2,000 2,545E-07 5,653E-05 ! regulation of epithelial cell differentiation GO:0030856 18 9 2,000 3,813E-07 7,763E-05 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 3,813E-07 7,166E-05 ! negative regulation of MAPKKK cascade GO:0043409 20 10 2,000 5,441E-07 9,495E-05 ! mammary gland development GO:0030879 93 40 3,000 6,405E-07 1,043E-04 ! positive regulation of peptide secretion GO:0002793 24 11 2,000 7,473E-07 1,141E-04 ! skeletal muscle tissue development GO:0007519 223 100 4,000 7,697E-07 1,106E-04 GO:0060538|skeletal muscle organ development, ! regulation of hormone metabolic process GO:0032350 28 12 2,000 9,951E-07 1,351E-04 ! gland morphogenesis GO:0022612 31 13 2,000 1,292E-06 1,661E-04 ! protein homooligomerization GO:0051260 84 49 3,000 1,468E-06 1,793E-04 ! lipid localization GO:0010876 32 14 2,000 1,643E-06 1,911E-04 GO:0019915|lipid storage, ! positive regulation of protein polymerization GO:0032273 27 14 2,000 1,643E-06 1,824E-04 ! regulation of vasodilation GO:0042312 27 15 2,000 2,051E-06 2,178E-04 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 2,051E-06 2,087E-04 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 2,000 3,057E-06 2,988E-04 ! myoblast differentiation GO:0045445 50 17 2,000 3,057E-06 2,873E-04 ! positive regulation of protein complex assembly GO:0031334 34 18 2,000 3,665E-06 3,316E-04 ! positive regulation of hormone secretion GO:0046887 35 19 2,000 4,346E-06 3,792E-04 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 4,888E-06 4,118E-04 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 5,107E-06 4,159E-04 ! pancreas development GO:0031016 40 20 2,000 5,107E-06 4,025E-04 ! regulation of fatty acid metabolic process GO:0019217 45 20 2,000 5,107E-06 3,899E-04 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 5,841E-06 4,324E-04 ! regulation of vasoconstriction GO:0019229 40 21 2,000 5,951E-06 4,276E-04 ! negative regulation of kinase activity GO:0033673 145 70 3,000 6,187E-06 4,319E-04 ! inactivation of MAPK activity GO:0000188 45 22 2,000 6,883E-06 4,671E-04 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 6,883E-06 4,544E-04 ! negative regulation of transferase activity GO:0051348 155 74 3,000 7,726E-06 4,967E-04 ! positive regulation of cytoskeleton organization GO:0051495 52 24 2,000 9,024E-06 5,653E-04 ! membrane depolarization GO:0051899 45 24 2,000 9,024E-06 5,512E-04 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 2,000 9,024E-06 5,377E-04 ! protein oligomerization GO:0051259 149 79 3,000 1,003E-05 5,831E-04 ! vasculogenesis GO:0001570 49 25 2,000 1,024E-05 5,819E-04 ! regulation of insulin secretion GO:0050796 42 25 2,000 1,024E-05 5,687E-04 ! regulation of smooth muscle contraction GO:0006940 48 26 2,000 1,156E-05 6,278E-04 ! regulation of cellular ketone metabolic process GO:0010565 51 26 2,000 1,156E-05 6,142E-04 ! regulation of blood coagulation GO:0030193 46 26 2,000 1,156E-05 6,011E-04 ! regulation of peptidase activity GO:0052547 150 82 3,000 1,163E-05 5,917E-04 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 1,299E-05 6,479E-04 ! regulation of endothelial cell proliferation GO:0001936 60 27 2,000 1,299E-05 6,349E-04 ! fat cell differentiation GO:0045444 57 28 2,000 1,454E-05 6,963E-04 ! regulation of peptide secretion GO:0002791 52 29 2,000 1,619E-05 7,608E-04 ! gland development GO:0048732 220 91 3,000 1,757E-05 8,097E-04 ! negative regulation of protein kinase cascade GO:0010741 72 30 2,000 1,797E-05 8,131E-04 ! regulation of coagulation GO:0050818 52 30 2,000 1,797E-05 7,983E-04 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 2,000 1,987E-05 8,67E-04 ! cholesterol homeostasis GO:0042632 60 33 2,000 2,406E-05 1,031E-03 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 46 33 2,000 2,406E-05 1,014E-03 ! cholesterol transport GO:0030301 62 34 2,000 2,636E-05 1,092E-03 ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 2,636E-05 1,073E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 2,793E-05 1,119E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 2,793E-05 1,101E-03 ! sterol transport GO:0015918 63 35 2,000 2,88E-05 1,117E-03 ! tissue remodeling GO:0048771 78 37 2,000 3,411E-05 1,302E-03 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 3,411E-05 1,282E-03 ! regulation of microtubule-based process GO:0032886 86 37 2,000 3,411E-05 1,262E-03 ! neutral lipid metabolic process GO:0006638 54 38 2,000 3,699E-05 1,349E-03 GO:0006639|acylglycerol metabolic process, ! cellular response to insulin stimulus GO:0032869 85 38 2,000 3,699E-05 1,329E-03 ! carbohydrate homeostasis GO:0033500 59 39 2,000 4,002E-05 1,417E-03 GO:0042593|glucose homeostasis, ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 4,185E-05 1,461E-03 ! lipid homeostasis GO:0055088 75 40 2,000 4,321E-05 1,487E-03 ! glycerol ether metabolic process GO:0006662 57 40 2,000 4,321E-05 1,466E-03 ! regulation of hormone secretion GO:0046883 69 41 2,000 4,657E-05 1,558E-03 ! mesenchymal cell development GO:0014031 94 41 2,000 4,657E-05 1,537E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! organic ether metabolic process GO:0018904 59 42 2,000 5,009E-05 1,632E-03 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 5,009E-05 1,61E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 5,852E-05 1,857E-03 ! vesicle fusion GO:0006906 20 7 1,000 5,852E-05 1,833E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 6,592E-05 2,038E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 6,592E-05 2,013E-03 ! positive regulation of protein transport GO:0051222 80 46 2,000 6,592E-05 1,988E-03 ! response to insulin stimulus GO:0032868 98 47 2,000 7,033E-05 2,095E-03 ! regulation of JAK-STAT cascade GO:0046425 76 48 2,000 7,492E-05 2,205E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 7,795E-05 2,267E-03 ! male meiosis GO:0007140 9 8 1,000 7,795E-05 2,24E-03 ! regulation of lipid kinase activity GO:0043550 17 8 1,000 7,795E-05 2,214E-03 ! ER overload response GO:0006983 13 8 1,000 7,795E-05 2,189E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 1,000 1,001E-04 2,779E-03 ! vesicle organization GO:0016050 127 53 2,000 1,009E-04 2,769E-03 ! regulation of muscle contraction GO:0006937 94 54 2,000 1,067E-04 2,896E-03 ! regulation of protein polymerization GO:0032271 117 55 2,000 1,127E-04 3,025E-03 ! response to UV GO:0009411 120 55 2,000 1,127E-04 2,993E-03 ! skeletal muscle fiber development GO:0048741 130 56 2,000 1,189E-04 3,124E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 1,25E-04 3,249E-03 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 1,000 1,25E-04 3,215E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 1,25E-04 3,181E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 1,254E-04 3,158E-03 ! muscle fiber development GO:0048747 131 57 2,000 1,254E-04 3,126E-03 ! regulation of intracellular transport GO:0032386 108 57 2,000 1,254E-04 3,094E-03 ! positive regulation of cell migration GO:0030335 137 58 2,000 1,321E-04 3,226E-03 ! positive regulation of organelle organization GO:0010638 108 58 2,000 1,321E-04 3,195E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,526E-04 3,655E-03 ! regulation of smoothened signaling pathway GO:0008589 27 11 1,000 1,526E-04 3,62E-03 ! positive regulation of secretion GO:0051047 110 61 2,000 1,535E-04 3,606E-03 ! regulation of protein complex assembly GO:0043254 132 63 2,000 1,69E-04 3,931E-03 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 1,771E-04 4,081E-03 ! regulation of B cell proliferation GO:0030888 22 12 1,000 1,829E-04 4,177E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 1,829E-04 4,138E-03 ! localization within membrane GO:0051668 26 12 1,000 1,829E-04 4,1E-03 ! positive regulation of cell motion GO:0051272 157 65 2,000 1,854E-04 4,117E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 1,94E-04 4,27E-03 ! organelle fusion GO:0048284 36 13 1,000 2,16E-04 4,711E-03 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 2,16E-04 4,669E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 2,409E-04 5,161E-03 ! regulation of MAPKKK cascade GO:0043408 157 72 2,000 2,51E-04 5,333E-03 ! cell-cell junction assembly GO:0007043 32 14 1,000 2,517E-04 5,301E-03 ! regulation of RNA stability GO:0043487 33 14 1,000 2,517E-04 5,255E-03 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 3,312E-04 6,856E-03 ! negative regulation of inflammatory response GO:0050728 24 16 1,000 3,312E-04 6,799E-03 ! muscle cell differentiation GO:0042692 178 81 2,000 3,553E-04 7,232E-03 ! response to hypoxia GO:0001666 178 81 2,000 3,553E-04 7,173E-03 ! response to oxygen levels GO:0070482 183 83 2,000 3,817E-04 7,643E-03 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 4,093E-04 8,129E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 4,213E-04 8,301E-03 ! regulation of protein transport GO:0051223 165 87 2,000 4,382E-04 8,564E-03 GO:0070201|regulation of establishment of protein localization, ! negative regulation of defense response GO:0031348 27 19 1,000 4,704E-04 9,12E-03 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 5,221E-04 0,01004281 ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 5,221E-04 9,964E-03 ! cell-cell junction organization GO:0045216 43 20 1,000 5,221E-04 9,887E-03 ! regulation of membrane potential GO:0042391 179 94 2,000 5,495E-04 0,01032658 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 5,668E-04 0,01056926 ! lipid phosphorylation GO:0046834 43 21 1,000 5,764E-04 0,0106679 ! regulation of protein localization GO:0032880 188 97 2,000 6,023E-04 0,01106258 ! interphase of mitotic cell cycle GO:0051329 224 98 2,000 6,205E-04 0,01131322 ! peptidyl-serine modification GO:0018209 50 22 1,000 6,334E-04 0,01146147 ! positive regulation of B cell activation GO:0050871 42 22 1,000 6,334E-04 0,01137719 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 7,551E-04 0,01346503 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 7,551E-04 0,01336746 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 7,551E-04 0,01327129 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 8,199E-04 0,01430673 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 8,199E-04 0,01420527 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 8,872E-04 0,01526409 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 8,872E-04 0,01515735 GO:0045936|negative regulation of phosphate metabolic process, ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 8,872E-04 0,01505209 ! negative regulation of cell development GO:0010721 83 26 1,000 8,872E-04 0,01494828 GO:0050768|negative regulation of neurogenesis, ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 1,03E-03 0,01722947 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 1,03E-03 0,01711227 ! vesicle docking GO:0048278 55 28 1,000 1,03E-03 0,01699664 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 1,105E-03 0,01811346 ! regulation of B cell activation GO:0050864 55 30 1,000 1,182E-03 0,01925699 ! cell junction assembly GO:0034329 85 31 1,000 1,263E-03 0,02042656 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 1,263E-03 0,02029218 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 1,345E-03 0,0214802 ! negative regulation of response to external stimulus GO:0032102 50 33 1,000 1,43E-03 0,02269291 ! membrane docking GO:0022406 69 35 1,000 1,609E-03 0,02535247 ! calcium-mediated signaling GO:0019722 67 35 1,000 1,609E-03 0,02518995 ! cell junction organization GO:0034330 96 37 1,000 1,797E-03 0,02795553 ! glycogen metabolic process GO:0005977 63 38 1,000 1,894E-03 0,02929009 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 1,995E-03 0,03064592 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 64 39 1,000 1,995E-03 0,03045439 GO:0006073|cellular glucan metabolic process, ! establishment or maintenance of cell polarity GO:0007163 96 41 1,000 2,202E-03 0,03341937 ! energy reserve metabolic process GO:0006112 76 44 1,000 2,533E-03 0,03819221 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 2,648E-03 0,03968038 ! induction of apoptosis by intracellular signals GO:0008629 95 45 1,000 2,648E-03 0,03943843 ! positive regulation of cell cycle GO:0045787 96 48 1,000 3,007E-03 0,0445187 ! regulation of inflammatory response GO:0050727 84 48 1,000 3,007E-03 0,04425051 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 3,131E-03 0,04580764 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 3,653E-03 0,05312595 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! activation of phospholipase C activity GO:0007202 110 54 1,000 3,79E-03 0,0547835 GO:0010863|positive regulation of phospholipase C activity, ! membrane fusion GO:0006944 122 54 1,000 3,79E-03 0,05446124 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 3,929E-03 0,05612512 ! regulation of phospholipase activity GO:0010517 113 57 1,000 4,213E-03 0,05984003 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 4,359E-03 0,06155232 ! positive regulation of lipase activity GO:0060193 115 58 1,000 4,359E-03 0,06119857 ! lipid modification GO:0030258 112 60 1,000 4,657E-03 0,06501501 ! negative regulation of response to stimulus GO:0048585 106 61 1,000 4,81E-03 0,06676476 ! protein amino acid autophosphorylation GO:0046777 157 64 1,000 5,282E-03 0,07289837 ! negative regulation of cell growth GO:0030308 142 67 1,000 5,774E-03 0,07924311 ! regulation of lipase activity GO:0060191 137 68 1,000 5,942E-03 0,08110065 ! negative regulation of cell size GO:0045792 144 69 1,000 6,113E-03 0,08296789 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 6,113E-03 0,0825095 ! regulation of caspase activity GO:0043281 136 74 1,000 7E-03 0,09396434 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 7,559E-03 0,10090832 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 7,559E-03 0,10035991 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 7,749E-03 0,10233372 ! meiosis GO:0007126 143 81 1,000 8,334E-03 0,1094616 GO:0051327|M phase of meiotic cell cycle, ! positive regulation of phosphorylation GO:0042327 149 81 1,000 8,334E-03 0,10887624 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 8,412E-03 0,10931474 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 8,412E-03 0,10873635 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 8,412E-03 0,10816405 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 8,412E-03 0,10759775 ! positive regulation of helicase activity GO:0051096 12 5 0,000 8,412E-03 0,10703735 ! neuron fate determination GO:0048664 7 5 0,000 8,412E-03 0,10648275 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 8,412E-03 0,10593387 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 8,412E-03 0,10539062 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 8,412E-03 0,10485291 ! polyol transport GO:0015791 12 5 0,000 8,412E-03 0,10432066 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 8,412E-03 0,10379379 ! response to superoxide GO:0000303 10 5 0,000 8,412E-03 0,10327221 ! negative regulation of bone resorption GO:0045779 10 5 0,000 8,412E-03 0,10275585 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 8,412E-03 0,10224463 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 8,412E-03 0,10173847 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 8,412E-03 0,10123729 ! female meiosis GO:0007143 10 5 0,000 8,412E-03 0,10074103 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 8,412E-03 0,10024961 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 8,412E-03 0,09976296 ! hypothalamus development GO:0021854 9 5 0,000 8,412E-03 0,09928102 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 8,412E-03 0,0988037 ! cobalt ion transport GO:0006824 11 5 0,000 8,412E-03 0,09833096 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 8,412E-03 0,09786272 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 8,412E-03 0,09739891 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 8,412E-03 0,09693948 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 8,412E-03 0,09648437 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 8,412E-03 0,09603351 ! embryonic camera-type eye development GO:0031076 12 5 0,000 8,412E-03 0,09558684 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 8,412E-03 0,09514431 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 8,412E-03 0,09470585 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 8,412E-03 0,09427142 ! transposition GO:0032196 9 5 0,000 8,412E-03 0,09384096 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 8,412E-03 0,09341441 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 8,412E-03 0,09299172 ! negative chemotaxis GO:0050919 16 5 0,000 8,412E-03 0,09257284 ! positive regulation of histone modification GO:0031058 6 5 0,000 8,412E-03 0,09215771 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 8,412E-03 0,0917463 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 8,412E-03 0,09133853 ! behavioral response to pain GO:0048266 10 5 0,000 8,412E-03 0,09093438 ! clathrin coat assembly GO:0048268 15 5 0,000 8,412E-03 0,09053379 ! Notch receptor processing GO:0007220 11 5 0,000 8,412E-03 0,09013671 ! regulation of dopamine uptake GO:0051584 9 5 0,000 8,412E-03 0,0897431 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 8,412E-03 0,08935291 ! micturition GO:0060073 9 5 0,000 8,412E-03 0,08896611 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 8,412E-03 0,08858263 ! copulation GO:0007620 9 5 0,000 8,412E-03 0,08820245 ! glial cell fate commitment GO:0021781 14 5 0,000 8,412E-03 0,08782551 ! protein maturation by protein folding GO:0022417 14 5 0,000 8,412E-03 0,08745179 ! bioluminescence GO:0008218 9 5 0,000 8,412E-03 0,08708123 ! spermidine metabolic process GO:0008216 7 5 0,000 8,412E-03 0,0867138 ! regulation of potassium ion transport GO:0043266 10 5 0,000 8,412E-03 0,08634945 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 8,412E-03 0,08598816 ! apoptotic cell clearance GO:0043277 23 5 0,000 8,412E-03 0,08562988 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 8,412E-03 0,08527457 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 8,412E-03 0,08492219 ! lipoprotein particle clearance GO:0034381 10 5 0,000 8,412E-03 0,08457272 ! grooming behavior GO:0007625 6 5 0,000 8,412E-03 0,08422611 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 8,412E-03 0,08388233 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 8,412E-03 0,08354134 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 8,412E-03 0,08320312 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 8,412E-03 0,08286762 ! response to protozoan GO:0001562 13 5 0,000 8,412E-03 0,08253482 ! positive regulation of glycolysis GO:0045821 13 5 0,000 8,412E-03 0,08220468 ! lymph vessel development GO:0001945 10 5 0,000 8,412E-03 0,08187717 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 8,412E-03 0,08155226 ! endochondral ossification GO:0001958 17 5 0,000 8,412E-03 0,08122992 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 8,412E-03 0,08091012 ! single strand break repair GO:0000012 8 5 0,000 8,412E-03 0,08059282 ! parathyroid gland development GO:0060017 14 5 0,000 8,412E-03 0,08027801 ! anagen GO:0042640 7 5 0,000 8,412E-03 0,07996564 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 8,412E-03 0,0796557 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 8,412E-03 0,07934815 ! cytokine secretion GO:0050663 15 5 0,000 8,412E-03 0,07904296 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 8,412E-03 0,07874012 ! ceramide catabolic process GO:0046514 7 5 0,000 8,412E-03 0,07843958 ! skeletal myofibril assembly GO:0014866 12 5 0,000 8,412E-03 0,07814133 ! smooth muscle tissue development GO:0048745 32 5 0,000 8,412E-03 0,07784534 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 8,412E-03 0,07755159 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 8,412E-03 0,07726004 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 8,412E-03 0,07697068 ! cardiac muscle fiber development GO:0048739 12 5 0,000 8,412E-03 0,07668347 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 8,412E-03 0,0763984 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 8,412E-03 0,07611545 ! neutrophil mediated immunity GO:0002446 7 5 0,000 8,412E-03 0,07583458 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 8,412E-03 0,07555577 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 8,412E-03 0,07527901 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 8,412E-03 0,07500427 ! glycine biosynthetic process GO:0006545 7 5 0,000 8,412E-03 0,07473153 ! microvillus organization GO:0032528 8 5 0,000 8,412E-03 0,07446076 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 8,412E-03 0,07419195 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 8,412E-03 0,07392507 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 8,412E-03 0,07366011 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 8,412E-03 0,07339704 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 8,412E-03 0,07313584 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 8,412E-03 0,07287649 ! polyol catabolic process GO:0046174 9 5 0,000 8,412E-03 0,07261898 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 8,412E-03 0,07236328 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 8,412E-03 0,07210937 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 8,412E-03 0,07185724 ! muscle cell migration GO:0014812 8 5 0,000 8,412E-03 0,07160687 ! mitochondrial fission GO:0000266 8 5 0,000 8,412E-03 0,07135823 ! sister chromatid cohesion GO:0007062 15 5 0,000 8,412E-03 0,07111132 ! response to tumor necrosis factor GO:0034612 10 5 0,000 8,412E-03 0,0708661 ! mRNA transcription GO:0009299 10 5 0,000 8,412E-03 0,07062258 ! nerve growth factor processing GO:0032455 9 5 0,000 8,412E-03 0,07038072 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 8,412E-03 0,07014051 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 8,412E-03 0,06990194 ! anaerobic glycolysis GO:0019642 6 5 0,000 8,412E-03 0,06966498 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 8,412E-03 0,06942963 ! monocyte activation GO:0042117 10 5 0,000 8,412E-03 0,06919586 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 8,412E-03 0,06896366 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 8,412E-03 0,06873301 ! response to food GO:0032094 6 5 0,000 8,412E-03 0,0685039 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 8,412E-03 0,06827631 ! positive regulation of transporter activity GO:0032411 8 5 0,000 8,412E-03 0,06805023 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 8,412E-03 0,06782564 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 8,412E-03 0,06760253 ! forebrain neuron development GO:0021884 13 5 0,000 8,412E-03 0,06738089 ! lipoprotein catabolic process GO:0042159 11 5 0,000 8,412E-03 0,06716069 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 8,412E-03 0,06694192 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 8,412E-03 0,06672458 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 8,412E-03 0,06650864 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 8,412E-03 0,0662941 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 8,412E-03 0,06608093 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 8,412E-03 0,06586914 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 8,412E-03 0,06565869 ! lipid glycosylation GO:0030259 7 5 0,000 8,412E-03 0,06544959 ! nucleobase transport GO:0015851 6 5 0,000 8,412E-03 0,06524181 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 8,412E-03 0,06503535 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 8,412E-03 0,06483019 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 8,412E-03 0,06462632 ! basic amino acid transport GO:0015802 12 5 0,000 8,412E-03 0,06442373 ! cellular glucose homeostasis GO:0001678 6 5 0,000 8,412E-03 0,06422241 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 8,412E-03 0,06402234 ! actin nucleation GO:0045010 11 5 0,000 8,412E-03 0,06382351 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 8,412E-03 0,06362591 ! depurination GO:0045007 5 5 0,000 8,412E-03 0,06342954 ! depyrimidination GO:0045008 10 5 0,000 8,412E-03 0,06323437 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 8,412E-03 0,0630404 ! regulation of centrosome cycle GO:0046605 7 5 0,000 8,412E-03 0,06284762 ! G2/M transition checkpoint GO:0031576 8 5 0,000 8,412E-03 0,06265601 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 8,412E-03 0,06246556 ! zinc ion homeostasis GO:0055069 9 5 0,000 8,412E-03 0,06227627 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 8,412E-03 0,06208813 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 8,412E-03 0,06190112 ! forebrain morphogenesis GO:0048853 13 5 0,000 8,412E-03 0,06171523 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 8,412E-03 0,06153045 ! activated T cell proliferation GO:0050798 16 5 0,000 8,412E-03 0,06134678 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 8,412E-03 0,0611642 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 8,412E-03 0,0609827 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 8,412E-03 0,06080228 ! positive regulation of organ growth GO:0046622 6 5 0,000 8,412E-03 0,06062292 ! gamma-delta T cell activation GO:0046629 6 5 0,000 8,412E-03 0,06044462 ! response to arsenic GO:0046685 11 5 0,000 8,412E-03 0,06026736 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 8,412E-03 0,06009114 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 8,412E-03 0,05991595 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 8,412E-03 0,05974177 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 8,412E-03 0,05956861 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 8,412E-03 0,05939645 ! response to mercury ion GO:0046689 8 5 0,000 8,412E-03 0,05922527 ! response to cadmium ion GO:0046686 7 5 0,000 8,412E-03 0,05905509 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 8,412E-03 0,05888587 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 8,412E-03 0,05871763 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 8,412E-03 0,05855034 ! bile acid biosynthetic process GO:0006699 7 5 0,000 8,412E-03 0,05838401 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 8,412E-03 0,05821861 ! ganglioside catabolic process GO:0006689 12 5 0,000 8,412E-03 0,05805415 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 8,412E-03 0,05789062 ! decidualization GO:0046697 11 5 0,000 8,412E-03 0,05772801 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 8,412E-03 0,0575663 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 8,412E-03 0,0574055 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 8,412E-03 0,0572456 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 8,412E-03 0,05708658 ! embryonic cleavage GO:0040016 6 5 0,000 8,412E-03 0,05692845 ! peroxisome fission GO:0016559 5 5 0,000 8,412E-03 0,05677119 ! histone demethylation GO:0016577 13 5 0,000 8,412E-03 0,05661479 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 8,412E-03 0,05645926 ! mitotic recombination GO:0006312 9 5 0,000 8,412E-03 0,05630458 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 8,412E-03 0,05615074 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 8,412E-03 0,05599774 ! metaphase plate congression GO:0051310 7 5 0,000 8,412E-03 0,05584557 ! regulation of sterol transport GO:0032371 7 5 0,000 8,412E-03 0,05569423 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 8,412E-03 0,0555437 ! enteric nervous system development GO:0048484 8 5 0,000 8,412E-03 0,05539399 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 8,412E-03 0,05524508 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 8,412E-03 0,05509697 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 8,412E-03 0,05494965 ! muscle cell proliferation GO:0033002 12 5 0,000 8,412E-03 0,05480312 ! skeletal muscle regeneration GO:0043403 8 5 0,000 8,412E-03 0,05465737 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 8,412E-03 0,05451239 ! B cell homeostasis GO:0001782 13 5 0,000 8,412E-03 0,05436818 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 8,412E-03 0,05422472 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 8,412E-03 0,05408203 ! metaphase GO:0051323 11 5 0,000 8,412E-03 0,05394008 ! melatonin biosynthetic process GO:0030187 7 5 0,000 8,412E-03 0,05379888 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 8,412E-03 0,05365841 ! cellular response to nutrient GO:0031670 8 5 0,000 8,412E-03 0,05351867 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 8,412E-03 0,05337966 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 8,412E-03 0,05324137 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 8,412E-03 0,0531038 ! regulation of hair follicle development GO:0051797 10 5 0,000 8,412E-03 0,05296693 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 8,412E-03 0,05283077 ! response to redox state GO:0051775 6 5 0,000 8,412E-03 0,05269531 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 8,412E-03 0,05256054 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 8,412E-03 0,05242645 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 8,412E-03 0,05229305 ! brown fat cell differentiation GO:0050873 7 5 0,000 8,412E-03 0,05216033 ! regulation of telomerase activity GO:0051972 7 5 0,000 8,412E-03 0,05202828 ! galactolipid metabolic process GO:0019374 7 5 0,000 8,412E-03 0,05189689 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 8,412E-03 0,05176617 ! porphyrin catabolic process GO:0006787 12 5 0,000 8,412E-03 0,05163611 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 8,412E-03 0,05150669 ! striatum development GO:0021756 14 5 0,000 8,412E-03 0,05137793 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 8,412E-03 0,0512498 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 8,412E-03 0,05112231 ! glial cell migration GO:0008347 10 5 0,000 8,412E-03 0,05099546 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 8,412E-03 0,05086923 ! neural plate morphogenesis GO:0001839 7 5 0,000 8,412E-03 0,05074363 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 8,412E-03 0,05061865 ! somatic stem cell maintenance GO:0035019 15 5 0,000 8,412E-03 0,05049428 ! T cell activation during immune response GO:0002286 9 5 0,000 8,412E-03 0,05037052 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 8,412E-03 0,05024736 ! negative regulation of lipase activity GO:0060192 8 5 0,000 8,412E-03 0,05012481 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 8,412E-03 0,05000285 ! neuroprotection GO:0043526 8 5 0,000 8,412E-03 0,04988148 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 8,412E-03 0,0497607 ! regulation of sensory perception GO:0051931 8 5 0,000 8,412E-03 0,04964051 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 8,412E-03 0,04952089 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 8,412E-03 0,04940185 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 8,412E-03 0,04928338 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 8,412E-03 0,04916548 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 8,412E-03 0,04904814 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 8,412E-03 0,04893136 ! sequestering of calcium ion GO:0051208 7 5 0,000 8,412E-03 0,04881513 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 8,412E-03 0,04869946 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 8,412E-03 0,04858433 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 8,412E-03 0,04846974 ! spindle assembly GO:0051225 6 5 0,000 8,412E-03 0,04835569 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 8,412E-03 0,04824218 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 8,412E-03 0,0481292 ! protein palmitoylation GO:0018345 12 5 0,000 8,412E-03 0,04801675 ! drug metabolic process GO:0017144 7 5 0,000 8,412E-03 0,04790483 ! stem cell division GO:0017145 11 5 0,000 8,412E-03 0,04779342 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 8,412E-03 0,04768253 ! organ regeneration GO:0031100 7 5 0,000 8,412E-03 0,04757215 ! carnitine metabolic process GO:0009437 8 5 0,000 8,412E-03 0,04746229 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 8,412E-03 0,04735293 ! meiotic cell cycle GO:0051321 144 82 1,000 8,533E-03 0,04792266 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 8,734E-03 0,04894051 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of growth GO:0045926 168 85 1,000 9,143E-03 0,05111441 ! positive regulation of cell activation GO:0050867 161 86 1,000 9,351E-03 0,05215569 GO:0002696|positive regulation of leukocyte activation, ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01008635 0,05612974 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01008635 0,05600217 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01008635 0,05587519 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01008635 0,05574877 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01008635 0,05562293 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01008635 0,05549765 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01008635 0,05537294 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01008635 0,05524878 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01008635 0,05512518 ! response to oxygen radical GO:0000305 11 6 0,000 0,01008635 0,05500214 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01008635 0,05487964 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01008635 0,05475768 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01008635 0,05463627 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01008635 0,05451539 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01008635 0,05439505 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01008635 0,05427524 ! forebrain regionalization GO:0021871 9 6 0,000 0,01008635 0,05415595 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01008635 0,05403719 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01008635 0,05391894 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01008635 0,05380122 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01008635 0,053684 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01008635 0,0535673 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01008635 0,0534511 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01008635 0,0533354 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01008635 0,05322021 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01008635 0,05310551 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01008635 0,05299131 ! malate metabolic process GO:0006108 13 6 0,000 0,01008635 0,05287759 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01008635 0,05276436 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01008635 0,05265162 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01008635 0,05253935 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01008635 0,05242757 ! protein refolding GO:0042026 15 6 0,000 0,01008635 0,05231626 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01008635 0,05220542 ! opsonization GO:0008228 8 6 0,000 0,01008635 0,05209505 ! mating behavior GO:0007617 7 6 0,000 0,01008635 0,05198514 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01008635 0,0518757 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01008635 0,05176672 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01008635 0,05165819 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01008635 0,05155012 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01008635 0,0514425 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01008635 0,05133533 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01008635 0,0512286 ! toxin metabolic process GO:0009404 11 6 0,000 0,01008635 0,05112232 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01008635 0,05101647 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01008635 0,05091107 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01008635 0,0508061 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01008635 0,05070156 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,01008635 0,05059745 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01008635 0,05049376 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01008635 0,05039051 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01008635 0,05028767 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01008635 0,05018525 ! thymic T cell selection GO:0045061 16 6 0,000 0,01008635 0,05008325 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01008635 0,04998166 ! protein lipoylation GO:0009249 10 6 0,000 0,01008635 0,04988048 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01008635 0,04977971 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01008635 0,04967935 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01008635 0,04957939 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01008635 0,04947983 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01008635 0,04938068 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01008635 0,04928191 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01008635 0,04918355 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01008635 0,04908557 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01008635 0,04898799 ! hyperosmotic response GO:0006972 10 6 0,000 0,01008635 0,04889079 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01008635 0,04879397 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01008635 0,04869754 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01008635 0,04860149 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01008635 0,04850582 ! urea metabolic process GO:0019627 7 6 0,000 0,01008635 0,04841052 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01008635 0,0483156 ! neutrophil activation GO:0042119 7 6 0,000 0,01008635 0,04822105 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01008635 0,04812687 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01008635 0,04803305 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01008635 0,04793961 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01008635 0,04784652 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01008635 0,04775379 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01008635 0,04766143 ! neuron apoptosis GO:0051402 15 6 0,000 0,01008635 0,04756942 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01008635 0,04747776 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01008635 0,04738646 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01008635 0,0472955 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01008635 0,0472049 ! carnitine transport GO:0015879 10 6 0,000 0,01008635 0,04711464 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01008635 0,04702473 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01008635 0,04693516 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01008635 0,04684593 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01008635 0,04675703 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01008635 0,04666848 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01008635 0,04658026 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01008635 0,04649237 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01008635 0,04640482 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01008635 0,04631759 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01008635 0,04623069 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01008635 0,04614411 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01008635 0,04605786 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01008635 0,04597193 ! response to UV-C GO:0010225 14 6 0,000 0,01008635 0,04588633 ! astrocyte development GO:0014002 16 6 0,000 0,01008635 0,04580104 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01008635 0,04571606 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01008635 0,0456314 ! interaction with symbiont GO:0051702 14 6 0,000 0,01008635 0,04554706 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01008635 0,04546302 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01008635 0,04537929 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01008635 0,04529588 ! response to copper ion GO:0046688 10 6 0,000 0,01008635 0,04521277 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01008635 0,04512996 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01008635 0,04504745 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01008635 0,04496525 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01008635 0,04488335 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01008635 0,04480174 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01008635 0,04472043 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01008635 0,04463941 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01008635 0,04455869 ! hair follicle maturation GO:0048820 8 6 0,000 0,01008635 0,04447826 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01008635 0,04439812 ! Schwann cell development GO:0014044 15 6 0,000 0,01008635 0,04431827 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01008635 0,0442387 ! response to pheromone GO:0019236 6 6 0,000 0,01008635 0,04415942 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01008635 0,04408042 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01008635 0,04400171 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01008635 0,04392327 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01008635 0,04384512 ! subpallium development GO:0021544 15 6 0,000 0,01008635 0,04376724 ! neural tube patterning GO:0021532 8 6 0,000 0,01008635 0,04368964 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01008635 0,04361231 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01008635 0,04353526 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01008635 0,04345848 ! G2 phase GO:0051319 16 6 0,000 0,01008635 0,04338197 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01008635 0,04330572 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01008635 0,04322975 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01008635 0,04315404 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01008635 0,0430786 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01008635 0,04300342 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01008635 0,0429285 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01008635 0,04285384 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01008635 0,04277944 ! receptor internalization GO:0031623 11 6 0,000 0,01008635 0,0427053 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,01008635 0,04263141 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,01008635 0,04255778 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01008635 0,04248441 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01008635 0,04241129 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01008635 0,04233841 ! protein deubiquitination GO:0016579 16 6 0,000 0,01008635 0,04226579 ! protein destabilization GO:0031648 9 6 0,000 0,01008635 0,04219342 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01008635 0,04212129 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01008635 0,04204941 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01008635 0,04197778 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01008635 0,04190639 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01008635 0,04183524 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01008635 0,04176433 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01008635 0,04169367 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01008635 0,04162324 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01008635 0,04155305 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01008635 0,04148309 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01008635 0,04141337 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01008635 0,04134389 ! neural plate development GO:0001840 9 6 0,000 0,01008635 0,04127463 ! catecholamine transport GO:0051937 9 6 0,000 0,01008635 0,04120561 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01008635 0,04113682 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01008635 0,04106826 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01008635 0,04099993 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01008635 0,04093182 ! maternal placenta development GO:0001893 12 6 0,000 0,01008635 0,04086394 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01008635 0,04079629 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01008635 0,04072885 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01008635 0,04066165 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01008635 0,04059466 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01008635 0,04052789 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01008635 0,04046134 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01008635 0,04039501 GO:0055081|anion homeostasis, ! ossification GO:0001503 205 91 1,000 0,01042027 0,04166402 ! bone development GO:0060348 206 92 1,000 0,01064036 0,04247452 ! positive regulation of MAP kinase activity GO:0043406 174 93 1,000 0,01086251 0,04329056 ! regulation of defense response GO:0031347 171 95 1,000 0,01131294 0,04501225 ! ATP biosynthetic process GO:0006754 197 95 1,000 0,01131294 0,04493906 ! tRNA transcription GO:0009304 17 7 0,000 0,01175766 0,0466298 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,01175766 0,04655422 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,01175766 0,04647889 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01175766 0,0464038 ! regulation of helicase activity GO:0051095 16 7 0,000 0,01175766 0,04632896 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,01175766 0,04625435 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,01175766 0,04617999 ! sleep GO:0030431 16 7 0,000 0,01175766 0,04610586 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01175766 0,04603198 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,01175766 0,04595833 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01175766 0,04588491 ! prostate gland development GO:0030850 14 7 0,000 0,01175766 0,04581173 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,01175766 0,04573878 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01175766 0,04566606 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01175766 0,04559358 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,01175766 0,04552132 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01175766 0,04544929 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,01175766 0,04537749 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,01175766 0,04530592 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01175766 0,04523457 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,01175766 0,04516345 ! glycolipid transport GO:0046836 11 7 0,000 0,01175766 0,04509255 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01175766 0,04502187 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,01175766 0,04495141 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 0,01175766 0,04488118 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,01175766 0,04481116 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,01175766 0,04474136 ! mRNA stabilization GO:0048255 18 7 0,000 0,01175766 0,04467178 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,01175766 0,04460241 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,01175766 0,04453326 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,01175766 0,04446432 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,01175766 0,0443956 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,01175766 0,04432709 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01175766 0,04425879 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01175766 0,0441907 ! lipoprotein transport GO:0042953 14 7 0,000 0,01175766 0,04412282 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,01175766 0,04405514 ! rhythmic behavior GO:0007622 17 7 0,000 0,01175766 0,04398768 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,01175766 0,04392042 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,01175766 0,04385336 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,01175766 0,04378652 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,01175766 0,04371987 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01175766 0,04365343 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,01175766 0,04358718 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01175766 0,04352114 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,01175766 0,0434553 ! mechanosensory behavior GO:0007638 16 7 0,000 0,01175766 0,04338966 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,01175766 0,04332421 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,01175766 0,04325897 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,01175766 0,04319392 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,01175766 0,04312906 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01175766 0,0430644 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01175766 0,04299993 ! spinal cord patterning GO:0021511 14 7 0,000 0,01175766 0,04293566 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,01175766 0,04287157 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,01175766 0,04280768 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01175766 0,04274398 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,01175766 0,04268047 ! adrenal gland development GO:0030325 17 7 0,000 0,01175766 0,04261714 ! cysteine metabolic process GO:0006534 13 7 0,000 0,01175766 0,04255401 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,01175766 0,04249106 ! ovulation GO:0030728 10 7 0,000 0,01175766 0,04242829 ! adenohypophysis development GO:0021984 11 7 0,000 0,01175766 0,04236571 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,01175766 0,04230332 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,01175766 0,04224111 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,01175766 0,04217908 ! microtubule nucleation GO:0007020 21 7 0,000 0,01175766 0,04211723 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01175766 0,04205557 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,01175766 0,04199408 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01175766 0,04193278 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,01175766 0,04187165 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,01175766 0,0418107 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01175766 0,04174993 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,01175766 0,04168934 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,01175766 0,04162892 ! galactose metabolic process GO:0006012 13 7 0,000 0,01175766 0,04156867 ! response to dietary excess GO:0002021 8 7 0,000 0,01175766 0,0415086 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01175766 0,04144871 ! intracellular pH reduction GO:0051452 13 7 0,000 0,01175766 0,04138898 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01175766 0,04132943 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,01175766 0,04127005 ! organ growth GO:0035265 15 7 0,000 0,01175766 0,04121084 ! nucleoside transport GO:0015858 11 7 0,000 0,01175766 0,0411518 ! nucleoside salvage GO:0043174 11 7 0,000 0,01175766 0,04109292 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,01175766 0,04103422 ! male sex determination GO:0030238 15 7 0,000 0,01175766 0,04097568 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,01175766 0,04091731 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,01175766 0,04085911 ! parturition GO:0007567 16 7 0,000 0,01175766 0,04080107 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,01175766 0,0407432 ! rRNA modification GO:0000154 14 7 0,000 0,01175766 0,04068549 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,01175766 0,04062794 ! spindle checkpoint GO:0031577 16 7 0,000 0,01175766 0,04057056 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,01175766 0,04051333 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,01175766 0,04045627 ! monocyte differentiation GO:0030224 16 7 0,000 0,01175766 0,04039937 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,01175766 0,04034263 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01175766 0,04028605 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,01175766 0,04022963 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,01175766 0,04017336 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,01175766 0,04011725 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01175766 0,0400613 ! fibrinolysis GO:0042730 11 7 0,000 0,01175766 0,04000551 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,01175766 0,03994987 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,01175766 0,03989438 ! eating behavior GO:0042755 8 7 0,000 0,01175766 0,03983905 ! B cell lineage commitment GO:0002326 21 7 0,000 0,01175766 0,03978387 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01175766 0,03972884 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,01175766 0,03967397 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,01175766 0,03961925 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,01175766 0,03956467 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,01175766 0,03951025 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01175766 0,03945598 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,01175766 0,03940186 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,01175766 0,03934788 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,01175766 0,03929405 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,01175766 0,03924037 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01175766 0,03918684 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,01175766 0,03913345 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,01175766 0,03908021 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01175766 0,03902711 ! histone ubiquitination GO:0016574 9 7 0,000 0,01175766 0,03897416 ! regulation of meiosis GO:0040020 12 7 0,000 0,01175766 0,03892135 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,01175766 0,03886868 ! T cell lineage commitment GO:0002360 16 7 0,000 0,01175766 0,03881615 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,01175766 0,03876377 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01175766 0,03871153 ! membrane to membrane docking GO:0022614 14 7 0,000 0,01175766 0,03865943 ! transcription termination GO:0006353 14 7 0,000 0,01175766 0,03860746 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01175766 0,03855564 ! anaphase GO:0051322 18 7 0,000 0,01175766 0,03850396 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,01175766 0,03845241 ! axonal fasciculation GO:0007413 19 7 0,000 0,01175766 0,03840101 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,01175766 0,03834974 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,01175766 0,03829861 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,01175766 0,03824761 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,01175766 0,03819675 ! diuresis GO:0030146 12 7 0,000 0,01175766 0,03814602 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01175766 0,03809543 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01175766 0,03804497 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01175766 0,03799465 ! antibiotic transport GO:0042891 9 7 0,000 0,01175766 0,03794446 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01175766 0,0378944 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,01175766 0,03784447 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,01175766 0,03779468 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,01175766 0,03774501 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,01175766 0,03769548 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,01175766 0,03764607 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,01175766 0,0375968 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01175766 0,03754765 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01175766 0,03749863 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,01175766 0,03744974 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,01175766 0,03740098 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,01175766 0,03735235 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,01175766 0,03730384 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,01175766 0,03725545 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,01175766 0,03720719 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,01175766 0,03715906 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,01175766 0,03711105 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,01175766 0,03706317 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01175766 0,0370154 ! muscle adaptation GO:0043500 13 7 0,000 0,01175766 0,03696777 ! embryonic heart tube development GO:0035050 14 7 0,000 0,01175766 0,03692025 ! retina homeostasis GO:0001895 12 7 0,000 0,01175766 0,03687285 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,01175766 0,03682558 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,01175766 0,03677843 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,01175766 0,0367314 ! mRNA transport GO:0051028 185 100 1,000 0,01247447 0,03892097 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,01342619 0,04183695 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,01342619 0,04178366 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,01342619 0,0417305 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,01342619 0,04167747 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,01342619 0,04162458 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,01342619 0,04157183 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,01342619 0,04151921 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,01342619 0,04146672 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,01342619 0,04141436 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,01342619 0,04136213 ! meiotic prophase I GO:0007128 14 8 0,000 0,01342619 0,04131004 ! response to zinc ion GO:0010043 12 8 0,000 0,01342619 0,04125808 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,01342619 0,04120625 ! oligopeptide transport GO:0006857 16 8 0,000 0,01342619 0,04115454 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,01342619 0,04110297 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,01342619 0,04105153 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,01342619 0,04100021 ! signal peptide processing GO:0006465 12 8 0,000 0,01342619 0,04094903 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,01342619 0,04089797 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,01342619 0,04084704 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,01342619 0,04079623 ! succinate metabolic process GO:0006105 17 8 0,000 0,01342619 0,04074556 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,01342619 0,040695 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,01342619 0,04064457 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,01342619 0,04059427 ! estrogen metabolic process GO:0008210 17 8 0,000 0,01342619 0,04054409 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,01342619 0,04049404 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,01342619 0,04044411 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,01342619 0,0403943 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,01342619 0,04034461 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01342619 0,04029505 ! reflex GO:0060004 17 8 0,000 0,01342619 0,04024561 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,01342619 0,04019629 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,01342619 0,04014709 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,01342619 0,04009801 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,01342619 0,04004905 ! pigment granule organization GO:0048753 17 8 0,000 0,01342619 0,04000021 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,01342619 0,03995149 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,01342619 0,03990289 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,01342619 0,0398544 ! astrocyte differentiation GO:0048708 19 8 0,000 0,01342619 0,03980603 ! histidine catabolic process GO:0006548 10 8 0,000 0,01342619 0,03975778 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,01342619 0,03970965 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,01342619 0,03966163 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,01342619 0,03961373 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,01342619 0,03956595 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,01342619 0,03951828 ! melanin metabolic process GO:0006582 17 8 0,000 0,01342619 0,03947072 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,01342619 0,03942328 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,01342619 0,03937596 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,01342619 0,03932874 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,01342619 0,03928164 ! macrophage activation GO:0042116 13 8 0,000 0,01342619 0,03923466 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,01342619 0,03918778 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,01342619 0,03914102 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,01342619 0,03909436 ! purine salvage GO:0043101 12 8 0,000 0,01342619 0,03904782 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,01342619 0,03900139 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01342619 0,03895507 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,01342619 0,03890886 ! osteoblast development GO:0002076 17 8 0,000 0,01342619 0,03886276 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,01342619 0,03881677 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,01342619 0,03877089 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,01342619 0,03872511 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,01342619 0,03867945 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,01342619 0,03863389 ! response to UV-B GO:0010224 17 8 0,000 0,01342619 0,03858844 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,01342619 0,03854309 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,01342619 0,03849785 ! intermediate filament organization GO:0045109 12 8 0,000 0,01342619 0,03845272 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,01342619 0,0384077 ! cellular extravasation GO:0045123 13 8 0,000 0,01342619 0,03836277 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,01342619 0,03831796 ! response to antibiotic GO:0046677 11 8 0,000 0,01342619 0,03827325 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,01342619 0,03822864 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,01342619 0,03818413 ! DNA topological change GO:0006265 12 8 0,000 0,01342619 0,03813973 ! response to tropane GO:0014073 15 8 0,000 0,01342619 0,03809544 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,01342619 0,03805124 ! melanosome transport GO:0032402 13 8 0,000 0,01342619 0,03800715 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,01342619 0,03796316 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,01342619 0,03791927 ! mast cell activation GO:0045576 14 8 0,000 0,01342619 0,03787549 ! multicellular organismal aging GO:0010259 20 8 0,000 0,01342619 0,0378318 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,01342619 0,03778822 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,01342619 0,03774473 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,01342619 0,03770135 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,01342619 0,03765806 ! nucleosome disassembly GO:0006337 14 8 0,000 0,01342619 0,03761488 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,01342619 0,03757179 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,01342619 0,0375288 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,01342619 0,03748591 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,01342619 0,03744312 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,01342619 0,03740042 ! intracellular lipid transport GO:0032365 16 8 0,000 0,01342619 0,03735783 ! response to tumor cell GO:0002347 16 8 0,000 0,01342619 0,03731533 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,01342619 0,03727292 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,01342619 0,03723062 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,01342619 0,0371884 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,01342619 0,03714629 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,01342619 0,03710427 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,01342619 0,03706234 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,01342619 0,03702051 ! hormone catabolic process GO:0042447 17 8 0,000 0,01342619 0,03697877 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,01342619 0,03693713 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,01342619 0,03689558 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,01342619 0,03685413 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,01342619 0,03681276 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,01342619 0,03677149 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,01342619 0,03673032 ! adult feeding behavior GO:0008343 10 8 0,000 0,01342619 0,03668923 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,01342619 0,03664824 ! ATP catabolic process GO:0006200 11 8 0,000 0,01342619 0,03660733 ! blastocyst growth GO:0001832 19 8 0,000 0,01342619 0,03656652 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,01342619 0,0365258 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,01342619 0,03648517 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,01342619 0,03644464 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,01342619 0,03640419 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,01342619 0,03636383 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,01342619 0,03632356 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,01342619 0,03628338 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,01342619 0,03624328 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,01342619 0,03620328 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,01342619 0,03616336 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,01342619 0,03612354 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,01342619 0,0360838 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,01342619 0,03604415 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,01342619 0,03600458 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,01342619 0,0359651 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,01342619 0,03592571 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,01342619 0,0358864 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,01342619 0,03584718 ! axon extension GO:0048675 16 9 0,000 0,01509195 0,04025068 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,01509195 0,04020679 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,01509195 0,04016299 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,01509195 0,04011928 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,01509195 0,04007568 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,01509195 0,04003216 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,01509195 0,03998874 ! reproductive behavior GO:0019098 22 9 0,000 0,01509195 0,03994542 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,01509195 0,03990219 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,01509195 0,03985905 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,01509195 0,03981601 ! UTP metabolic process GO:0046051 10 9 0,000 0,01509195 0,03977306 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,01509195 0,0397302 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,01509195 0,03968743 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,01509195 0,03964476 ! artery development GO:0060840 25 9 0,000 0,01509195 0,03960217 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,01509195 0,03955968 ! regulation of glycolysis GO:0006110 20 9 0,000 0,01509195 0,03951728 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,01509195 0,03947497 ! equilibrioception GO:0050957 20 9 0,000 0,01509195 0,03943275 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,01509195 0,03939062 ! chemosensory behavior GO:0007635 21 9 0,000 0,01509195 0,03934858 ! microtubule bundle formation GO:0001578 22 9 0,000 0,01509195 0,03930663 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,01509195 0,03926477 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,01509195 0,039223 ! leukocyte degranulation GO:0043299 16 9 0,000 0,01509195 0,03918132 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,01509195 0,03913973 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,01509195 0,03909822 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,01509195 0,0390568 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,01509195 0,03901547 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,01509195 0,03897423 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,01509195 0,03893308 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,01509195 0,03889201 ! protein targeting to ER GO:0045047 25 9 0,000 0,01509195 0,03885102 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,01509195 0,03881013 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,01509195 0,03876932 ! T cell selection GO:0045058 27 9 0,000 0,01509195 0,03872859 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,01509195 0,03868796 ! glycine catabolic process GO:0006546 15 9 0,000 0,01509195 0,0386474 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,01509195 0,03860693 ! endosome organization GO:0007032 20 9 0,000 0,01509195 0,03856655 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,01509195 0,03852625 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,01509195 0,03848604 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,01509195 0,0384459 ! mannose metabolic process GO:0006013 13 9 0,000 0,01509195 0,03840586 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,01509195 0,03836589 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,01509195 0,03832601 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,01509195 0,03828621 ! receptor clustering GO:0043113 20 9 0,000 0,01509195 0,0382465 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,01509195 0,03820686 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,01509195 0,03816731 ! retinol metabolic process GO:0042572 20 9 0,000 0,01509195 0,03812784 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,01509195 0,03808845 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,01509195 0,03804915 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,01509195 0,03800992 ! macrophage differentiation GO:0030225 15 9 0,000 0,01509195 0,03797077 ! oligodendrocyte development GO:0014003 11 9 0,000 0,01509195 0,03793171 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,01509195 0,03789273 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,01509195 0,03785382 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,01509195 0,037815 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,01509195 0,03777625 ! response to amine stimulus GO:0014075 13 9 0,000 0,01509195 0,03773759 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,01509195 0,037699 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,01509195 0,03766049 ! erythrocyte development GO:0048821 17 9 0,000 0,01509195 0,03762206 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,01509195 0,03758371 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,01509195 0,03754544 ! renal water homeostasis GO:0003091 15 9 0,000 0,01509195 0,03750725 ! postreplication repair GO:0006301 25 9 0,000 0,01509195 0,03746913 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,01509195 0,03743109 ! icosanoid secretion GO:0032309 15 9 0,000 0,01509195 0,03739313 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,01509195 0,03735524 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,01509195 0,03731743 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,01509195 0,0372797 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,01509195 0,03724204 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,01509195 0,03720446 ! sterol catabolic process GO:0016127 14 9 0,000 0,01509195 0,03716696 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,01509195 0,03712953 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,01509195 0,03709218 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,01509195 0,0370549 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,01509195 0,03701769 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,01509195 0,03698056 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,01509195 0,03694351 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,01509195 0,03690653 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,01509195 0,03686962 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,01509195 0,03683279 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,01509195 0,03679603 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,01509195 0,03675934 ! purine base metabolic process GO:0006144 25 9 0,000 0,01509195 0,03672273 ! pigment granule transport GO:0051904 17 9 0,000 0,01509195 0,03668619 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,01509195 0,03664972 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,01509195 0,03661333 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,01509195 0,03657701 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,01509195 0,03654076 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,01509195 0,03650458 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,01509195 0,03646847 ! mitochondrion localization GO:0051646 18 9 0,000 0,01509195 0,03643243 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,01675494 0,04040702 ! regulation of developmental growth GO:0048638 16 10 0,000 0,01675494 0,04036718 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,01675494 0,04032741 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,01675494 0,04028771 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,01675494 0,0402481 ! associative learning GO:0008306 21 10 0,000 0,01675494 0,04020856 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,01675494 0,0401691 ! phosphate transport GO:0006817 24 10 0,000 0,01675494 0,04012972 ! cell volume homeostasis GO:0006884 17 10 0,000 0,01675494 0,04009042 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,01675494 0,04005119 ! CTP metabolic process GO:0046036 11 10 0,000 0,01675494 0,04001204 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,01675494 0,03997296 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,01675494 0,03993397 ! GTP metabolic process GO:0046039 11 10 0,000 0,01675494 0,03989504 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,01675494 0,0398562 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,01675494 0,03981743 ! social behavior GO:0035176 29 10 0,000 0,01675494 0,03977873 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,01675494 0,03974011 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,01675494 0,03970157 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,01675494 0,0396631 ! androgen metabolic process GO:0008209 17 10 0,000 0,01675494 0,0396247 ! phospholipid efflux GO:0033700 19 10 0,000 0,01675494 0,03958638 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,01675494 0,03954813 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,01675494 0,03950996 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,01675494 0,03947186 ! lung alveolus development GO:0048286 26 10 0,000 0,01675494 0,03943383 ! pathogenesis GO:0009405 17 10 0,000 0,01675494 0,03939588 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,01675494 0,039358 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,01675494 0,03932019 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,01675494 0,03928245 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,01675494 0,03924479 ! endoderm development GO:0007492 18 10 0,000 0,01675494 0,0392072 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,01675494 0,03916968 ! arginine catabolic process GO:0006527 17 10 0,000 0,01675494 0,03913223 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,01675494 0,03909486 ! proline metabolic process GO:0006560 13 10 0,000 0,01675494 0,03905755 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,01675494 0,03902032 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,01675494 0,03898316 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,01675494 0,03894607 ! V(D)J recombination GO:0033151 34 10 0,000 0,01675494 0,03890905 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,01675494 0,0388721 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,01675494 0,03883521 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,01675494 0,0387984 ! B cell proliferation GO:0042100 19 10 0,000 0,01675494 0,03876166 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,01675494 0,03872499 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,01675494 0,03868839 ! multicellular organism growth GO:0035264 19 10 0,000 0,01675494 0,03865186 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,01675494 0,03861539 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,01675494 0,038579 ! ruffle organization GO:0031529 17 10 0,000 0,01675494 0,03854267 ! epithelial cell development GO:0002064 21 10 0,000 0,01675494 0,03850641 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,01675494 0,03847022 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,01675494 0,0384341 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,01675494 0,03839805 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,01675494 0,03836206 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,01675494 0,03832614 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,01675494 0,03829029 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,01675494 0,0382545 ! motor axon guidance GO:0008045 22 10 0,000 0,01675494 0,03821878 ! copper ion homeostasis GO:0055070 13 10 0,000 0,01675494 0,03818313 ! regulation of bone resorption GO:0045124 25 10 0,000 0,01675494 0,03814755 ! protein heterooligomerization GO:0051291 17 10 0,000 0,01675494 0,03811203 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,01675494 0,03807657 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,01675494 0,03804119 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,01675494 0,03800586 ! segment specification GO:0007379 15 10 0,000 0,01675494 0,03797061 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,01675494 0,03793542 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,01675494 0,03790029 ! blastoderm segmentation GO:0007350 19 10 0,000 0,01675494 0,03786523 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,01675494 0,03783024 ! response to dsRNA GO:0043331 23 10 0,000 0,01675494 0,03779531 ! DNA ligation GO:0006266 18 10 0,000 0,01675494 0,03776044 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,01675494 0,03772564 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,01675494 0,0376909 ! melanosome localization GO:0032400 16 10 0,000 0,01675494 0,03765622 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,01675494 0,03762161 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,01675494 0,03758707 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,01675494 0,03755258 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,01675494 0,03751816 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,01675494 0,03748381 ! induction of an organ GO:0001759 17 10 0,000 0,01675494 0,03744951 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,01675494 0,03741528 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,01675494 0,03738111 ! protein sumoylation GO:0016925 17 10 0,000 0,01675494 0,037347 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,01675494 0,03731296 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,01675494 0,03727898 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,01675494 0,03724506 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,01675494 0,0372112 ! salivary gland development GO:0007431 28 10 0,000 0,01675494 0,0371774 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,01675494 0,03714366 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,01675494 0,03710999 ! midbrain development GO:0030901 14 10 0,000 0,01675494 0,03707637 ! musculoskeletal movement GO:0050881 16 10 0,000 0,01675494 0,03704282 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,01675494 0,03700933 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,01675494 0,0369759 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,01675494 0,03694252 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,01675494 0,03690921 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,01675494 0,03687596 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,01675494 0,03684277 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,01675494 0,03680964 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,01675494 0,03677656 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,01675494 0,03674355 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,01675494 0,0367106 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,01675494 0,0366777 ! blastocyst formation GO:0001825 18 10 0,000 0,01675494 0,03664487 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,01675494 0,03661209 ! cerebellar cortex development GO:0021695 16 10 0,000 0,01675494 0,03657937 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,01675494 0,03654671 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,01675494 0,03651411 ! response to nicotine GO:0035094 20 10 0,000 0,01675494 0,03648157 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,01675494 0,03644908 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,01675494 0,03641665 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,01841517 0,03998957 ! respiratory burst GO:0045730 17 11 0,000 0,01841517 0,03995405 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,01841517 0,0399186 ! neuron fate specification GO:0048665 18 11 0,000 0,01841517 0,03988321 ! telencephalon cell migration GO:0022029 23 11 0,000 0,01841517 0,03984789 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,01841517 0,03981262 ! thyroid gland development GO:0030878 26 11 0,000 0,01841517 0,03977742 ! synapsis GO:0007129 14 11 0,000 0,01841517 0,03974228 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,01841517 0,03970721 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,01841517 0,03967219 ! response to pain GO:0048265 27 11 0,000 0,01841517 0,03963724 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,01841517 0,03960235 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,01841517 0,03956751 ! blood vessel remodeling GO:0001974 30 11 0,000 0,01841517 0,03953275 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,01841517 0,03949804 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,01841517 0,03946339 ! bone resorption GO:0045453 16 11 0,000 0,01841517 0,0394288 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,01841517 0,03939428 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 0,01841517 0,03935981 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,01841517 0,03932541 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,01841517 0,03929106 ! melanocyte differentiation GO:0030318 20 11 0,000 0,01841517 0,03925678 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,01841517 0,03922255 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,01841517 0,03918838 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,01841517 0,03915428 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,01841517 0,03912023 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,01841517 0,03908624 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,01841517 0,03905231 ! UV protection GO:0009650 20 11 0,000 0,01841517 0,03901844 ! adult heart development GO:0007512 16 11 0,000 0,01841517 0,03898463 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,01841517 0,03895088 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,01841517 0,03891718 ! macroautophagy GO:0016236 19 11 0,000 0,01841517 0,03888355 ! temperature homeostasis GO:0001659 18 11 0,000 0,01841517 0,03884997 ! behavioral fear response GO:0001662 27 11 0,000 0,01841517 0,03881645 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,01841517 0,03878299 ! negative regulation of ossification GO:0030279 27 11 0,000 0,01841517 0,03874958 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,01841517 0,03871623 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,01841517 0,03868294 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,01841517 0,03864971 ! regulation of organ growth GO:0046620 14 11 0,000 0,01841517 0,03861654 ! pigment granule localization GO:0051875 20 11 0,000 0,01841517 0,03858342 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,01841517 0,03855035 ! vasoconstriction GO:0042310 20 11 0,000 0,01841517 0,03851735 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,01841517 0,0384844 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,01841517 0,03845151 ! embryonic axis specification GO:0000578 19 11 0,000 0,01841517 0,03841867 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,01841517 0,03838589 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,01841517 0,03835317 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,01841517 0,0383205 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,01841517 0,03828788 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,01841517 0,03825533 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,01841517 0,03822282 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,01841517 0,03819038 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,01841517 0,03815798 ! prophase GO:0051324 17 11 0,000 0,01841517 0,03812565 ! neuroblast proliferation GO:0007405 25 11 0,000 0,01841517 0,03809337 ! nucleosome positioning GO:0016584 15 11 0,000 0,01841517 0,03806114 ! regulation of isotype switching GO:0045191 24 11 0,000 0,01841517 0,03802896 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,01841517 0,03799684 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,01841517 0,03796478 ! apical protein localization GO:0045176 18 11 0,000 0,01841517 0,03793277 ! acid secretion GO:0046717 20 11 0,000 0,01841517 0,03790081 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,01841517 0,03786891 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,01841517 0,03783706 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,01841517 0,03780526 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,01841517 0,03777352 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,01841517 0,03774183 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,01841517 0,0377102 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,01841517 0,03767861 ! cholesterol efflux GO:0033344 21 11 0,000 0,01841517 0,03764708 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,01841517 0,03761561 ! oocyte development GO:0048599 20 11 0,000 0,01841517 0,03758418 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,01841517 0,03755281 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,01841517 0,03752149 ! embryonic gut development GO:0048566 19 11 0,000 0,01841517 0,03749022 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,01841517 0,037459 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,01841517 0,03742784 ! activation of innate immune response GO:0002218 16 11 0,000 0,01841517 0,03739673 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,01841517 0,03736567 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,01841517 0,03733466 ! lysogeny GO:0030069 22 11 0,000 0,01841517 0,0373037 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,01841517 0,0372728 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,01841517 0,03724194 ! sequestering of metal ion GO:0051238 15 11 0,000 0,01841517 0,03721114 ! regulation of embryonic development GO:0045995 35 11 0,000 0,01841517 0,03718038 ! nucleus localization GO:0051647 22 11 0,000 0,01841517 0,03714968 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,02007265 0,04045997 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,02007265 0,04042661 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,02007265 0,04039331 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,02007265 0,04036006 ! virus-host interaction GO:0019048 30 12 0,000 0,02007265 0,04032687 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,02007265 0,04029374 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,02007265 0,04026065 ! protein complex disassembly GO:0043241 28 12 0,000 0,02007265 0,04022763 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,02007265 0,04019465 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,02007265 0,04016173 ! hippocampus development GO:0021766 29 12 0,000 0,02007265 0,04012887 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,02007265 0,04009606 ! T cell proliferation GO:0042098 32 12 0,000 0,02007265 0,0400633 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,02007265 0,04003059 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,02007265 0,03999794 ! ventral spinal cord development GO:0021517 25 12 0,000 0,02007265 0,03996534 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,02007265 0,0399328 ! drug transport GO:0015893 16 12 0,000 0,02007265 0,03990031 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,02007265 0,03986787 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,02007265 0,03983548 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,02007265 0,03980315 ! polyamine metabolic process GO:0006595 18 12 0,000 0,02007265 0,03977087 ! focal adhesion formation GO:0048041 37 12 0,000 0,02007265 0,03973864 ! mitotic spindle organization GO:0007052 23 12 0,000 0,02007265 0,03970646 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,02007265 0,03967433 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,02007265 0,03964226 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,02007265 0,03961024 ! lipid digestion GO:0044241 21 12 0,000 0,02007265 0,03957827 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,02007265 0,03954635 ! entry into host cell GO:0030260 34 12 0,000 0,02007265 0,03951449 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02007265 0,03948267 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,02007265 0,03945091 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,02007265 0,03941919 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,02007265 0,03938753 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,02007265 0,03935592 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,02007265 0,03932436 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,02007265 0,03929285 ! snRNA metabolic process GO:0016073 30 12 0,000 0,02007265 0,03926139 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,02007265 0,03922998 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,02007265 0,03919862 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,02007265 0,03916731 ! cranial nerve development GO:0021545 23 12 0,000 0,02007265 0,03913606 ! fucose catabolic process GO:0019317 25 12 0,000 0,02007265 0,03910485 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,02007265 0,03907369 ! histone acetylation GO:0016573 27 12 0,000 0,02007265 0,03904258 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,02007265 0,03901152 ! autonomic nervous system development GO:0048483 24 12 0,000 0,02007265 0,03898051 ! zymogen activation GO:0031638 18 12 0,000 0,02007265 0,03894955 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,02007265 0,03891863 ! T cell homeostasis GO:0043029 28 12 0,000 0,02007265 0,03888777 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,02007265 0,03885696 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,02007265 0,03882619 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,02007265 0,03879547 ! oocyte differentiation GO:0009994 21 12 0,000 0,02007265 0,0387648 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,02007265 0,03873418 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,02007265 0,03870361 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,02007265 0,03867309 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,02007265 0,03864261 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,02007265 0,03861219 ! defense response to fungus GO:0050832 15 12 0,000 0,02007265 0,03858181 ! developmental induction GO:0031128 22 12 0,000 0,02007265 0,03855148 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,02007265 0,03852119 ! lamellipodium assembly GO:0030032 24 12 0,000 0,02007265 0,03849096 ! response to cold GO:0009409 17 12 0,000 0,02007265 0,03846077 ! establishment of cell polarity GO:0030010 21 12 0,000 0,02007265 0,03843063 ! regulation of synapse organization GO:0050807 18 12 0,000 0,02007265 0,03840053 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,02172737 0,04153362 ! cGMP metabolic process GO:0046068 18 13 0,000 0,02172737 0,04150115 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,02172737 0,04146872 ! regulation of chemokine production GO:0032642 18 13 0,000 0,02172737 0,04143635 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,02172737 0,04140403 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,02172737 0,04137176 ! peroxisomal transport GO:0043574 28 13 0,000 0,02172737 0,04133954 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,02172737 0,04130737 ! cartilage condensation GO:0001502 22 13 0,000 0,02172737 0,04127525 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,02172737 0,04124318 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,02172737 0,04121116 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,02172737 0,04117918 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,02172737 0,04114726 ! endocrine pancreas development GO:0031018 25 13 0,000 0,02172737 0,04111539 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,02172737 0,04108357 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,02172737 0,04105179 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,02172737 0,04102007 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,02172737 0,04098839 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,02172737 0,04095677 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,02172737 0,04092519 ! methionine metabolic process GO:0006555 31 13 0,000 0,02172737 0,04089366 ! plasma membrane organization GO:0007009 27 13 0,000 0,02172737 0,04086218 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,02172737 0,04083074 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,02172737 0,04079936 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,02172737 0,04076802 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,02172737 0,04073674 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,02172737 0,0407055 ! cytokine metabolic process GO:0042107 24 13 0,000 0,02172737 0,0406743 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,02172737 0,04064316 ! exocrine system development GO:0035272 34 13 0,000 0,02172737 0,04061206 ! asymmetric protein localization GO:0008105 24 13 0,000 0,02172737 0,04058102 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,02172737 0,04055001 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,02172737 0,04051906 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,02172737 0,04048815 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,02172737 0,04045729 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,02172737 0,04042648 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,02172737 0,04039571 ! protein homotetramerization GO:0051289 24 13 0,000 0,02172737 0,04036499 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,02172737 0,04033432 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,02172737 0,0403037 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,02172737 0,04027312 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,02172737 0,04024258 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,02172737 0,0402121 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,02172737 0,04018166 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,02172737 0,04015126 ! histone methylation GO:0016571 29 13 0,000 0,02172737 0,04012091 ! chromatin silencing GO:0006342 29 13 0,000 0,02172737 0,04009061 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,02172737 0,04006035 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,02172737 0,04003014 ! regulation of epidermis development GO:0045682 19 13 0,000 0,02172737 0,03999998 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,02172737 0,03996986 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,02172737 0,03993978 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,02172737 0,03990975 ! spleen development GO:0048536 24 13 0,000 0,02172737 0,03987977 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,02172737 0,03984983 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,02172737 0,03981993 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,02172737 0,03979008 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,02172737 0,03976028 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,02172737 0,03973051 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,02172737 0,0397008 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,02172737 0,03967113 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,02172737 0,0396415 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,02172737 0,03961192 ! insulin secretion GO:0030073 24 13 0,000 0,02172737 0,03958238 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,02172737 0,03955288 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,02172737 0,03952343 ! acrosome reaction GO:0007340 19 13 0,000 0,02172737 0,03949402 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,02172737 0,03946466 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,02172737 0,03943534 ! rRNA transcription GO:0009303 28 14 0,000 0,02337935 0,04240219 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,02337935 0,04237073 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,02337935 0,04233932 ! water transport GO:0006833 21 14 0,000 0,02337935 0,04230796 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,02337935 0,04227664 ! non-recombinational repair GO:0000726 29 14 0,000 0,02337935 0,04224537 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,02337935 0,04221415 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,02337935 0,04218297 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,02337935 0,04215184 ! RNA polyadenylation GO:0043631 32 14 0,000 0,02337935 0,04212076 ! palate development GO:0060021 32 14 0,000 0,02337935 0,04208972 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,02337935 0,04205872 ! regulated secretory pathway GO:0045055 24 14 0,000 0,02337935 0,04202777 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,02337935 0,04199687 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,02337935 0,04196601 ! arginine metabolic process GO:0006525 21 14 0,000 0,02337935 0,0419352 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,02337935 0,04190444 ! regulation of heart rate GO:0002027 25 14 0,000 0,02337935 0,04187371 ! fear response GO:0042596 34 14 0,000 0,02337935 0,04184304 ! organic alcohol transport GO:0015850 29 14 0,000 0,02337935 0,0418124 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,02337935 0,04178182 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,02337935 0,04175128 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,02337935 0,04172078 ! neutral amino acid transport GO:0015804 28 14 0,000 0,02337935 0,04169032 ! bone mineralization GO:0030282 18 14 0,000 0,02337935 0,04165992 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,02337935 0,04162955 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,02337935 0,04159923 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,02337935 0,04156896 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,02337935 0,04153872 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,02337935 0,04150854 ! regulation of cellular pH GO:0030641 27 14 0,000 0,02337935 0,04147839 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,02337935 0,04144829 ! ribosome assembly GO:0042255 18 14 0,000 0,02337935 0,04141823 ! cerebellum development GO:0021549 23 14 0,000 0,02337935 0,04138822 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,02337935 0,04135825 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,02337935 0,04132832 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,02337935 0,04129844 ! response to gamma radiation GO:0010332 30 14 0,000 0,02337935 0,0412686 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,02337935 0,04123881 ! NADP metabolic process GO:0006739 24 14 0,000 0,02337935 0,04120905 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,02337935 0,04117934 ! oxygen transport GO:0015671 22 14 0,000 0,02337935 0,04114967 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,02337935 0,04112005 ! male genitalia development GO:0030539 26 14 0,000 0,02337935 0,04109046 ! regulation of axon extension GO:0030516 43 14 0,000 0,02337935 0,04106092 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,02337935 0,04103143 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,02337935 0,04100197 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,02502858 0,04386286 ! lactation GO:0007595 30 15 0,000 0,02502858 0,04383141 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 0,02502858 0,04380001 ! reproductive cellular process GO:0048610 22 15 0,000 0,02502858 0,04376866 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,02502858 0,04373735 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,02502858 0,04370609 ! superoxide anion generation GO:0042554 22 15 0,000 0,02502858 0,04367487 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,02502858 0,0436437 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,02502858 0,04361257 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,02502858 0,04358148 ! copper ion transport GO:0006825 22 15 0,000 0,02502858 0,04355044 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,02502858 0,04351945 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,02502858 0,04348849 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,02502858 0,04345758 ! sulfate transport GO:0008272 27 15 0,000 0,02502858 0,04342672 ! response to cAMP GO:0051591 25 15 0,000 0,02502858 0,0433959 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,02502858 0,04336512 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,02502858 0,04333439 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,02502858 0,0433037 ! response to hexose stimulus GO:0009746 25 15 0,000 0,02502858 0,04327305 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,02502858 0,04324245 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,02502858 0,04321189 ! vesicle coating GO:0006901 38 15 0,000 0,02502858 0,04318137 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,02502858 0,0431509 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,02502858 0,04312047 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,02502858 0,04309008 ! regulation of exocytosis GO:0017157 26 15 0,000 0,02502858 0,04305973 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,02502858 0,04302943 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,02502858 0,04299917 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,02502858 0,04296895 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,02502858 0,04293878 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,02502858 0,04290865 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,02502858 0,04287856 ! histone deacetylation GO:0016575 24 15 0,000 0,02502858 0,04284851 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,02502858 0,0428185 ! water homeostasis GO:0030104 28 15 0,000 0,02502858 0,04278854 ! cofactor transport GO:0051181 30 15 0,000 0,02502858 0,04275862 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,02502858 0,04272874 ! muscle maintenance GO:0046716 26 15 0,000 0,02502858 0,0426989 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,02502858 0,0426691 ! intestinal absorption GO:0050892 31 15 0,000 0,02502858 0,04263934 ! dopamine metabolic process GO:0042417 35 15 0,000 0,02502858 0,04260963 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,02502858 0,04257996 ! heme biosynthetic process GO:0006783 33 15 0,000 0,02502858 0,04255033 ! cell killing GO:0001906 32 15 0,000 0,02502858 0,04252074 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,02502858 0,04249119 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,02502858 0,04246168 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,02502858 0,04243221 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,02502858 0,04240279 ! actin filament polymerization GO:0030041 27 15 0,000 0,02502858 0,0423734 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,02502858 0,04234406 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,02667507 0,04509841 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,02667507 0,04506722 ! positive regulation of cell size GO:0045793 29 16 0,000 0,02667507 0,04503608 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,02667507 0,04500498 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,02667507 0,04497392 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,02667507 0,0449429 ! bone remodeling GO:0046849 28 16 0,000 0,02667507 0,04491193 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,02667507 0,044881 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,02667507 0,04485011 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,02667507 0,04481926 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,02667507 0,04478846 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,02667507 0,0447577 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,02667507 0,04472698 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,02667507 0,0446963 ! startle response GO:0001964 28 16 0,000 0,02667507 0,04466567 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,02667507 0,04463507 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,02667507 0,04460452 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,02667507 0,04457401 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,02667507 0,04454354 ! protein polyubiquitination GO:0000209 41 16 0,000 0,02667507 0,04451312 ! glutamate metabolic process GO:0006536 25 16 0,000 0,02667507 0,04448273 ! pituitary gland development GO:0021983 30 16 0,000 0,02667507 0,04445239 ! response to osmotic stress GO:0006970 27 16 0,000 0,02667507 0,04442209 ! lysosomal transport GO:0007041 31 16 0,000 0,02667507 0,04439183 ! fructose metabolic process GO:0006000 25 16 0,000 0,02667507 0,04436161 ! L-amino acid transport GO:0015807 33 16 0,000 0,02667507 0,04433143 ! stem cell development GO:0048864 46 16 0,000 0,02667507 0,0443013 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,02667507 0,0442712 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,02667507 0,04424114 ! intermediate filament-based process GO:0045103 36 16 0,000 0,02667507 0,04421113 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,02667507 0,04418116 ! negative regulation of immune response GO:0050777 38 16 0,000 0,02667507 0,04415122 ! axon cargo transport GO:0008088 46 16 0,000 0,02667507 0,04412133 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,02667507 0,04409148 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,02667507 0,04406167 ! DNA replication initiation GO:0006270 28 16 0,000 0,02667507 0,0440319 ! neuron recognition GO:0008038 40 16 0,000 0,02667507 0,04400216 ! mRNA splice site selection GO:0006376 44 16 0,000 0,02667507 0,04397247 ! tissue regeneration GO:0042246 27 16 0,000 0,02667507 0,04394282 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,02667507 0,04391321 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,02667507 0,04388364 ! biomineral formation GO:0031214 22 16 0,000 0,02667507 0,04385411 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,02667507 0,04382462 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,02667507 0,04379516 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,02667507 0,04376575 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,02667507 0,04373638 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,02667507 0,04370705 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,02667507 0,04367775 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,02667507 0,0436485 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,02667507 0,04361928 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,02667507 0,0435901 ! peptide hormone processing GO:0016486 27 16 0,000 0,02667507 0,04356097 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,02831883 0,04621437 ! metencephalon development GO:0022037 32 17 0,000 0,02831883 0,04618352 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,02831883 0,04615271 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,02831883 0,04612194 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,02831883 0,04609121 ! signal complex assembly GO:0007172 47 17 0,000 0,02831883 0,04606053 ! filopodium assembly GO:0046847 42 17 0,000 0,02831883 0,04602988 ! endothelial cell migration GO:0043542 31 17 0,000 0,02831883 0,04599928 ! gene silencing by RNA GO:0031047 38 17 0,000 0,02831883 0,04596871 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,02831883 0,04593819 ! glial cell development GO:0021782 28 17 0,000 0,02831883 0,0459077 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,02831883 0,04587726 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,02831883 0,04584686 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,02831883 0,0458165 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,02831883 0,04578617 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,02831883 0,04575589 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,02831883 0,04572565 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,02831883 0,04569545 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,02831883 0,04566529 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,02831883 0,04563517 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,02831883 0,04560508 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,02831883 0,04557504 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,02831883 0,04554504 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,02831883 0,04551507 ! membrane budding GO:0006900 42 17 0,000 0,02831883 0,04548515 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,02831883 0,04545526 ! regulation of protein binding GO:0043393 33 17 0,000 0,02831883 0,04542542 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,02831883 0,04539561 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,02831883 0,04536584 ! genitalia development GO:0048806 32 17 0,000 0,02831883 0,04533611 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,02831883 0,04530642 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,02831883 0,04527677 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,02831883 0,04524716 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,02831883 0,04521759 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,02831883 0,04518805 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,02831883 0,04515856 ! steroid catabolic process GO:0006706 34 17 0,000 0,02831883 0,0451291 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,02831883 0,04509968 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,02831883 0,0450703 ! gas transport GO:0015669 26 17 0,000 0,02831883 0,04504096 ! organic cation transport GO:0015695 32 17 0,000 0,02831883 0,04501165 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,02831883 0,04498239 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,02831883 0,04495316 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,02831883 0,04492397 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,02995986 0,0474964 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,02995986 0,04746559 ! limbic system development GO:0021761 40 18 0,000 0,02995986 0,04743483 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,02995986 0,04740411 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,02995986 0,04737343 ! adult walking behavior GO:0007628 36 18 0,000 0,02995986 0,04734279 ! patterning of blood vessels GO:0001569 43 18 0,000 0,02995986 0,04731218 ! heart looping GO:0001947 34 18 0,000 0,02995986 0,04728162 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,02995986 0,0472511 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,02995986 0,04722061 ! centrosome cycle GO:0007098 26 18 0,000 0,02995986 0,04719017 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,02995986 0,04715976 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,02995986 0,04712939 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,02995986 0,04709906 ! glycine metabolic process GO:0006544 30 18 0,000 0,02995986 0,04706878 ! glutamine metabolic process GO:0006541 29 18 0,000 0,02995986 0,04703853 ! response to retinoic acid GO:0032526 31 18 0,000 0,02995986 0,04700832 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,02995986 0,04697814 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,02995986 0,04694801 ! DNA integration GO:0015074 32 18 0,000 0,02995986 0,04691791 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,02995986 0,04688786 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,02995986 0,04685784 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,02995986 0,04682786 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,02995986 0,04679792 ! neural crest cell migration GO:0001755 41 18 0,000 0,02995986 0,04676802 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,02995986 0,04673815 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,02995986 0,04670833 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,02995986 0,04667854 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,02995986 0,04664879 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,02995986 0,04661907 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,02995986 0,0465894 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,02995986 0,04655976 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,02995986 0,04653016 ! detection of bacterium GO:0016045 22 18 0,000 0,02995986 0,0465006 ! nerve development GO:0021675 34 18 0,000 0,02995986 0,04647108 ! defense response to virus GO:0051607 43 18 0,000 0,02995986 0,04644159 ! microspike assembly GO:0030035 46 18 0,000 0,02995986 0,04641214 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,02995986 0,04638273 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,02995986 0,04635335 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,03159817 0,04885717 ! positive regulation of translation GO:0045727 31 19 0,000 0,03159817 0,04882626 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,03159817 0,0487954 ! neuron maturation GO:0042551 46 19 0,000 0,03159817 0,04876458 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,03159817 0,04873379 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,03159817 0,04870304 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,03159817 0,04867234 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,03159817 0,04864167 ! inositol metabolic process GO:0006020 33 19 0,000 0,03159817 0,04861104 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,03159817 0,04858044 ! memory GO:0007613 34 19 0,000 0,03159817 0,04854989 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,03159817 0,04851937 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,03159817 0,0484889 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,03159817 0,04845846 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,03159817 0,04842806 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,03159817 0,0483977 ! cerebral cortex development GO:0021987 40 19 0,000 0,03159817 0,04836737 ! pigmentation during development GO:0048066 42 19 0,000 0,03159817 0,04833708 ! response to vitamin A GO:0033189 32 19 0,000 0,03159817 0,04830684 ! heme metabolic process GO:0042168 40 19 0,000 0,03159817 0,04827663 ! neuromuscular junction development GO:0007528 43 19 0,000 0,03159817 0,04824645 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,03159817 0,04821632 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,03159817 0,04818622 ! response to fungus GO:0009620 26 19 0,000 0,03159817 0,04815616 ! peptide cross-linking GO:0018149 39 19 0,000 0,03159817 0,04812614 ! protein export from nucleus GO:0006611 40 19 0,000 0,03159817 0,04809615 ! heart process GO:0003015 32 19 0,000 0,03159817 0,0480662 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,03159817 0,04803629 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,03159817 0,04800642 ! visual learning GO:0008542 38 19 0,000 0,03159817 0,04797658 ! cellular pigmentation GO:0033059 37 19 0,000 0,03159817 0,04794679 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,03159817 0,04791702 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,03159817 0,0478873 ! vitamin transport GO:0051180 31 19 0,000 0,03159817 0,04785761 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,03159817 0,04782796 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,03159817 0,04779834 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,03159817 0,04776877 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,03159817 0,04773922 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,03159817 0,04770972 ! cilium assembly GO:0042384 38 19 0,000 0,03159817 0,04768025 ! peptide hormone secretion GO:0030072 32 19 0,000 0,03159817 0,04765082 ! protein secretion GO:0009306 45 20 0,000 0,03323375 0,0500864 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,03323375 0,05005552 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,03323375 0,05002468 ! positive regulation of ossification GO:0045778 50 20 0,000 0,03323375 0,04999388 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,03323375 0,04996311 ! skin development GO:0043588 42 20 0,000 0,03323375 0,04993238 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,03323375 0,04990169 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,03323375 0,04987104 ! protein amino acid acetylation GO:0006473 41 20 0,000 0,03323375 0,04984043 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,03323375 0,04980985 ! response to vitamin GO:0033273 36 20 0,000 0,03323375 0,04977931 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,03323375 0,04974881 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,03323375 0,04971834 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,03323375 0,04968792 ! bile acid metabolic process GO:0008206 34 20 0,000 0,03323375 0,04965753 ! response to alkaloid GO:0043279 38 20 0,000 0,03323375 0,04962717 ! retinoid metabolic process GO:0001523 34 20 0,000 0,03323375 0,04959686 GO:0016101|diterpenoid metabolic process, ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,03323375 0,04956658 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,03323375 0,04953634 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,03323375 0,04950613 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,03323375 0,04947596 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 0,000 0,03323375 0,04944583 ! body fluid secretion GO:0007589 33 20 0,000 0,03323375 0,04941574 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,03323375 0,04938568 ! peptide secretion GO:0002790 38 20 0,000 0,03323375 0,04935566 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,03323375 0,04932567 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,03323375 0,04929572 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,03323375 0,04926581 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,03323375 0,04923593 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,03323375 0,04920609 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,03323375 0,04917629 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,03323375 0,04914652 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,03323375 0,04911679 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,03323375 0,0490871 ! regulation of glucose import GO:0046324 30 20 0,000 0,03323375 0,04905744 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,03323375 0,04902781 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,03323375 0,04899822 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,03323375 0,04896867 ! negative regulation of translation GO:0017148 32 20 0,000 0,03323375 0,04893915 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,03323375 0,04890967 ! regulation of cell killing GO:0031341 46 21 0,000 0,03486662 0,05128185 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,03486662 0,05125099 ! hormone secretion GO:0046879 39 21 0,000 0,03486662 0,05122017 ! cAMP metabolic process GO:0046058 41 21 0,000 0,03486662 0,05118939 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,03486662 0,05115865 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,03486662 0,05112794 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,03486662 0,05109727 ! ovarian follicle development GO:0001541 39 21 0,000 0,03486662 0,05106664 ! smooth muscle contraction GO:0006939 48 21 0,000 0,03486662 0,05103604 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,03486662 0,05100548 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,03486662 0,05097496 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,03486662 0,05094447 ! plasma membrane fusion GO:0045026 33 21 0,000 0,03486662 0,05091402 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,03486662 0,0508836 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,03486662 0,05085322 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,03486662 0,05082288 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,03486662 0,05079258 ! diencephalon development GO:0021536 36 21 0,000 0,03486662 0,05076231 ! collagen fibril organization GO:0030199 62 21 0,000 0,03486662 0,05073207 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,03486662 0,05070188 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,03486662 0,05067171 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,03486662 0,05064159 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,03486662 0,0506115 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,03486662 0,05058144 ! collagen catabolic process GO:0030574 29 21 0,000 0,03486662 0,05055142 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,03486662 0,05052144 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,03486662 0,05049149 ! sperm-egg recognition GO:0035036 23 21 0,000 0,03486662 0,05046158 ! actin filament-based movement GO:0030048 47 21 0,000 0,03486662 0,05043171 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,03486662 0,05040186 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,03649677 0,05272716 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,03649677 0,05269599 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,03649677 0,05266487 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,03649677 0,05263378 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,03649677 0,05260273 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,03649677 0,05257171 ! microtubule-based transport GO:0010970 59 22 0,000 0,03649677 0,05254073 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,03649677 0,05250979 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,03649677 0,05247888 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,03649677 0,05244801 ! cellular response to starvation GO:0009267 37 22 0,000 0,03649677 0,05241718 ! vacuolar transport GO:0007034 41 22 0,000 0,03649677 0,05238638 ! central nervous system neuron development GO:0021954 47 22 0,000 0,03649677 0,05235562 ! fucose metabolic process GO:0006004 44 22 0,000 0,03649677 0,05232489 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,03649677 0,0522942 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,03649677 0,05226355 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,03649677 0,05223293 ! ureteric bud development GO:0001657 50 22 0,000 0,03649677 0,05220235 ! cell aging GO:0007569 48 22 0,000 0,03649677 0,05217181 ! stem cell differentiation GO:0048863 57 22 0,000 0,03649677 0,0521413 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,03649677 0,05211082 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,03649677 0,05208039 ! cytolysis GO:0019835 27 22 0,000 0,03649677 0,05204998 ! renal system process GO:0003014 42 22 0,000 0,03649677 0,05201961 ! vasodilation GO:0042311 40 22 0,000 0,03649677 0,05198928 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,03649677 0,05195899 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,03649677 0,05192872 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 0,03649677 0,0518985 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,03649677 0,05186831 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,03649677 0,05183815 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,03649677 0,05180803 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,03649677 0,05177794 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,03649677 0,05174789 ! sarcomere organization GO:0045214 32 22 0,000 0,03649677 0,05171788 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,03649677 0,0516879 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,03649677 0,05165795 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,03649677 0,05162804 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,03649677 0,05159816 ! gut development GO:0048565 44 22 0,000 0,03649677 0,05156832 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,03649677 0,05153851 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,03649677 0,05150873 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,03649677 0,05147899 ! protein stabilization GO:0050821 41 22 0,000 0,03649677 0,05144929 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,03812422 0,0537125 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,03812422 0,05368154 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,03812422 0,05365062 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,03812422 0,05361973 ! gluconeogenesis GO:0006094 38 23 0,000 0,03812422 0,05358888 ! glycerol metabolic process GO:0006071 40 23 0,000 0,03812422 0,05355806 ! viral genome replication GO:0019079 44 23 0,000 0,03812422 0,05352728 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,03812422 0,05349654 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,03812422 0,05346583 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,03812422 0,05343515 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,03812422 0,05340451 ! regeneration GO:0031099 42 23 0,000 0,03812422 0,05337391 ! axis specification GO:0009798 43 23 0,000 0,03812422 0,05334334 ! visual behavior GO:0007632 46 23 0,000 0,03812422 0,05331281 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,03812422 0,05328231 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,03812422 0,05325184 ! response to ethanol GO:0045471 47 23 0,000 0,03812422 0,05322141 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,03812422 0,05319102 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,03812422 0,05316066 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,03812422 0,05313033 ! peroxisome organization GO:0007031 43 23 0,000 0,03812422 0,05310004 ! lysosome organization GO:0007040 47 23 0,000 0,03812422 0,05306979 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,03812422 0,05303956 ! vesicle targeting GO:0006903 49 23 0,000 0,03812422 0,05300938 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,03812422 0,05297922 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,03812422 0,0529491 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,03812422 0,05291902 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,03812422 0,05288897 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,03812422 0,05285895 ! DNA modification GO:0006304 36 23 0,000 0,03812422 0,05282897 ! fatty acid transport GO:0015908 47 23 0,000 0,03812422 0,05279902 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,03812422 0,05276911 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,03812422 0,05273923 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,03812422 0,05270938 ! hormone transport GO:0009914 41 23 0,000 0,03812422 0,05267957 ! cell-cell recognition GO:0009988 28 23 0,000 0,03812422 0,05264979 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,03812422 0,05262004 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,03812422 0,05259033 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,03812422 0,05256065 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,03974897 0,05476973 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,03974897 0,05473885 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,03974897 0,05470801 ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,03974897 0,05467721 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,03974897 0,05464644 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,03974897 0,05461571 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,03974897 0,05458501 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,03974897 0,05455434 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,03974897 0,05452371 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,03974897 0,05449311 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,03974897 0,05446255 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,03974897 0,05443202 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,03974897 0,05440153 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,03974897 0,05437107 GO:0042278|purine nucleoside metabolic process, ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,03974897 0,05434064 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,03974897 0,05431025 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,03974897 0,05427989 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,03974897 0,05424957 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,03974897 0,05421928 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,03974897 0,05418902 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,03974897 0,0541588 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,03974897 0,05412861 ! pallium development GO:0021543 56 24 0,000 0,03974897 0,05409845 ! oogenesis GO:0048477 44 24 0,000 0,03974897 0,05406833 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,03974897 0,05403824 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,03974897 0,05400819 ! platelet activation GO:0030168 41 24 0,000 0,03974897 0,05397817 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,03974897 0,05394818 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,03974897 0,05391823 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,03974897 0,0538883 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,03974897 0,05385842 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,03974897 0,05382856 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,03974897 0,05379874 ! regulation of amine transport GO:0051952 41 24 0,000 0,03974897 0,05376895 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,04137101 0,05593214 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,04137101 0,05590121 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,04137101 0,05587031 ! leukocyte adhesion GO:0007159 55 25 0,000 0,04137101 0,05583944 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,04137101 0,0558086 ! phototransduction GO:0007602 37 25 0,000 0,04137101 0,0557778 ! keratinization GO:0031424 37 25 0,000 0,04137101 0,05574704 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,04137101 0,05571631 ! vacuole organization GO:0007033 49 25 0,000 0,04137101 0,05568561 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,04137101 0,05565495 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,04137101 0,05562432 ! receptor metabolic process GO:0043112 53 25 0,000 0,04137101 0,05559372 ! chromosome condensation GO:0030261 48 25 0,000 0,04137101 0,05556316 ! regulation of behavior GO:0050795 48 25 0,000 0,04137101 0,05553263 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,04137101 0,05550213 ! interaction with host GO:0051701 66 25 0,000 0,04137101 0,05547167 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,04137101 0,05544124 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,04137101 0,05541085 ! immunoglobulin production GO:0002377 62 25 0,000 0,04137101 0,05538048 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,04137101 0,05535015 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,04137101 0,05531986 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,04137101 0,0552896 ! liver development GO:0001889 55 25 0,000 0,04137101 0,05525937 ! protein tetramerization GO:0051262 57 25 0,000 0,04137101 0,05522917 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,04299036 0,05735962 ! myelination GO:0042552 50 26 0,000 0,04299036 0,05732831 ! initiation of viral infection GO:0019059 60 26 0,000 0,04299036 0,05729703 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,04299036 0,05726579 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,04299036 0,05723458 ! molting cycle process GO:0022404 52 26 0,000 0,04299036 0,05720341 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,04299036 0,05717227 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,04299036 0,05714116 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,04299036 0,05711009 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,04299036 0,05707905 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,04299036 0,05704805 ! digestive system process GO:0022600 49 26 0,000 0,04299036 0,05701708 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,04299036 0,05698614 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,04299036 0,05695524 ! osteoblast differentiation GO:0001649 63 26 0,000 0,04299036 0,05692437 ! neural crest cell development GO:0014032 59 26 0,000 0,04299036 0,05689353 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,04299036 0,05686273 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,04299036 0,05683196 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,04299036 0,05680122 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,04299036 0,05677052 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,04299036 0,05673985 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,04299036 0,05670921 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,04299036 0,05667861 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,04299036 0,05664804 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,04299036 0,0566175 ! blastocyst development GO:0001824 50 26 0,000 0,04299036 0,05658699 ! telomere organization GO:0032200 46 26 0,000 0,04299036 0,05655652 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,04299036 0,05652608 ! neural tube closure GO:0001843 58 26 0,000 0,04299036 0,05649567 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,04299036 0,0564653 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,04299036 0,05643496 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,04299036 0,05640465 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,04460702 0,05849434 ! embryonic pattern specification GO:0009880 49 27 0,000 0,04460702 0,05846296 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,04460702 0,05843161 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,04460702 0,0584003 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,04460702 0,05836902 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,04460702 0,05833777 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,04460702 0,05830656 ! iron ion transport GO:0006826 65 27 0,000 0,04460702 0,05827538 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,04460702 0,05824423 ! superoxide metabolic process GO:0006801 41 27 0,000 0,04460702 0,05821312 ! tube lumen formation GO:0035148 59 27 0,000 0,04460702 0,05818204 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,04460702 0,05815099 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,04460702 0,05811998 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,04460702 0,058089 ! response to starvation GO:0042594 47 27 0,000 0,04460702 0,05805805 ! response to toxin GO:0009636 49 27 0,000 0,04460702 0,05802714 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,04460702 0,05799625 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,04460702 0,0579654 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,04460702 0,05793459 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,04460702 0,0579038 ! leukocyte proliferation GO:0070661 59 27 0,000 0,04460702 0,05787305 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,04460702 0,05784234 ! neuron fate commitment GO:0048663 52 28 0,000 0,046221 0,0599034 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,046221 0,05987164 ! protein amino acid acylation GO:0043543 59 28 0,000 0,046221 0,05983991 ! circadian rhythm GO:0007623 56 28 0,000 0,046221 0,05980821 ! dendrite development GO:0016358 67 28 0,000 0,046221 0,05977655 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,046221 0,05974492 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,046221 0,05971333 ! sperm motility GO:0030317 37 28 0,000 0,046221 0,05968177 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,046221 0,05965024 ! base-excision repair GO:0006284 41 28 0,000 0,046221 0,05961875 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,046221 0,05958728 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,046221 0,05955586 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,046221 0,05952446 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,046221 0,0594931 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,046221 0,05946177 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,046221 0,05943048 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,046221 0,05939921 ! glutathione metabolic process GO:0006749 42 28 0,000 0,046221 0,05936798 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,046221 0,05933679 ! lipid oxidation GO:0034440 48 28 0,000 0,046221 0,05930562 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,046221 0,05927449 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,046221 0,05924339 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,04783229 0,06127651 ! translational initiation GO:0006413 66 29 0,000 0,04783229 0,06124439 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,04783229 0,06121231 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,04783229 0,06118026 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,04783229 0,06114825 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,04783229 0,06111626 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,04783229 0,06108432 ! primary neural tube formation GO:0014020 61 29 0,000 0,04783229 0,0610524 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,04783229 0,06102052 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,04783229 0,06098867 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,04783229 0,06095686 ! somitogenesis GO:0001756 52 29 0,000 0,04783229 0,06092508 ! synaptogenesis GO:0007416 46 29 0,000 0,04783229 0,06089333 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,04783229 0,06086161 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,04783229 0,06082993 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,04783229 0,06079828 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,04783229 0,06076666 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,04944091 0,06277762 ! phenol metabolic process GO:0018958 56 30 0,000 0,04944091 0,06274501 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,04944091 0,06271244 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,04944091 0,06267989 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,04944091 0,06264738 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,04944091 0,0626149 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,04944091 0,06258246 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,04944091 0,06255005 ! acute-phase response GO:0006953 50 30 0,000 0,04944091 0,06251768 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,04944091 0,06248533 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,04944091 0,06245302 ! myofibril assembly GO:0030239 50 30 0,000 0,04944091 0,06242075 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,04944091 0,06238851 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,04944091 0,0623563 ! cell fate determination GO:0001709 64 30 0,000 0,04944091 0,06232412 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,04944091 0,06229198 ! phospholipid transport GO:0015914 65 30 0,000 0,04944091 0,06225987 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,04944091 0,06222779 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,04944091 0,06219575 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,04944091 0,06216374 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,04944091 0,06213176 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,04944091 0,06209982 GO:0048871|multicellular organismal homeostasis, ! alkaloid metabolic process GO:0009820 57 31 0,000 0,05104686 0,06408401 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,05104686 0,06405109 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,05104686 0,06401821 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,05104686 0,06398536 ! regulation of innate immune response GO:0045088 57 31 0,000 0,05104686 0,06395255 ! ovulation cycle process GO:0022602 55 31 0,000 0,05104686 0,06391977 ! peptide transport GO:0015833 60 31 0,000 0,05104686 0,06388703 ! male gonad development GO:0008584 56 31 0,000 0,05104686 0,06385431 ! iron ion homeostasis GO:0055072 60 31 0,000 0,05104686 0,06382163 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,05104686 0,06378899 ! detection of light stimulus GO:0009583 44 31 0,000 0,05104686 0,06375638 ! natural killer cell activation GO:0030101 50 31 0,000 0,05104686 0,0637238 ! ensheathment of neurons GO:0007272 64 31 0,000 0,05104686 0,06369125 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,05104686 0,06365874 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,05104686 0,06362626 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,05104686 0,06359382 ! eye morphogenesis GO:0048592 65 31 0,000 0,05104686 0,0635614 ! response to heat GO:0009408 54 31 0,000 0,05104686 0,06352902 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,05104686 0,06349668 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,05265014 0,06545765 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,05265014 0,06542435 ! collagen metabolic process GO:0032963 49 32 0,000 0,05265014 0,06539109 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,05265014 0,06535787 ! spindle organization GO:0007051 50 32 0,000 0,05265014 0,06532467 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,05265014 0,06529151 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,05265014 0,06525839 ! metanephros development GO:0001656 81 32 0,000 0,05265014 0,06522529 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,05265014 0,06519224 ! muscle cell development GO:0055001 52 32 0,000 0,05265014 0,06515921 ! mesoderm formation GO:0001707 73 32 0,000 0,05265014 0,06512622 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,05265014 0,06509326 ! ovulation cycle GO:0042698 57 32 0,000 0,05265014 0,06506033 ! peripheral nervous system development GO:0007422 68 32 0,000 0,05265014 0,06502744 ! BMP signaling pathway GO:0030509 71 32 0,000 0,05265014 0,06499458 ! hindbrain development GO:0030902 65 32 0,000 0,05265014 0,06496176 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,05265014 0,06492897 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,05265014 0,06489621 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,05265014 0,06486348 ! gene silencing GO:0016458 71 32 0,000 0,05265014 0,06483079 ! regulation of pH GO:0006885 56 33 0,000 0,05425075 0,06676805 ! pigment biosynthetic process GO:0046148 73 33 0,000 0,05425075 0,06673443 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,05425075 0,06670085 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,05425075 0,06666729 ! response to ionizing radiation GO:0010212 74 33 0,000 0,05425075 0,06663378 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,05425075 0,06660029 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,05425075 0,06656684 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,05425075 0,06653342 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,05425075 0,06650004 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,05425075 0,06646669 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,05425075 0,06643337 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,05425075 0,06640009 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,0558487 0,06832167 ! glial cell differentiation GO:0010001 67 34 0,000 0,0558487 0,06828748 ! post-embryonic development GO:0009791 76 34 0,000 0,0558487 0,06825332 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,0558487 0,06821919 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,0558487 0,0681851 ! spliceosome assembly GO:0000245 75 34 0,000 0,0558487 0,06815104 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,0558487 0,06811702 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,0558487 0,06808303 ! formation of primary germ layer GO:0001704 76 34 0,000 0,0558487 0,06804907 ! cell fate specification GO:0001708 56 34 0,000 0,0558487 0,06801515 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,0558487 0,06798126 ! adult locomotory behavior GO:0008344 62 34 0,000 0,0558487 0,0679474 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,0558487 0,06791358 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,057444 0,06981876 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,057444 0,06978404 ! negative regulation of secretion GO:0051048 68 35 0,000 0,057444 0,06974935 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,057444 0,0697147 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,057444 0,06968009 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,057444 0,06964551 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,057444 0,06961096 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,057444 0,06957645 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,057444 0,06954197 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,057444 0,06950753 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,057444 0,06947312 ! ceramide metabolic process GO:0006672 72 35 0,000 0,057444 0,06943874 ! telencephalon development GO:0021537 81 35 0,000 0,057444 0,0694044 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,057444 0,06937009 ! placenta development GO:0001890 53 35 0,000 0,057444 0,06933582 ! vesicle localization GO:0051648 70 35 0,000 0,057444 0,06930158 ! regulation of muscle development GO:0048634 82 36 0,000 0,05903665 0,07118783 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,05903665 0,07115271 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,05903665 0,07111762 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,05903665 0,07108257 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,05903665 0,07104756 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,05903665 0,07101257 ! positive regulation of cell development GO:0010720 85 36 0,000 0,05903665 0,07097763 ! protein targeting to membrane GO:0006612 75 36 0,000 0,05903665 0,07094271 ! regulation of proteolysis GO:0030162 77 36 0,000 0,05903665 0,07090784 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,05903665 0,07087299 ! aerobic respiration GO:0009060 56 36 0,000 0,05903665 0,07083818 ! cytokine production GO:0001816 68 36 0,000 0,05903665 0,07080341 ! embryonic organ development GO:0048568 67 36 0,000 0,05903665 0,07076866 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,05903665 0,07073396 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,05903665 0,07069928 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,06062665 0,07256782 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,06062665 0,07253228 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,06062665 0,07249678 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,06062665 0,07246131 ! sister chromatid segregation GO:0000819 65 37 0,000 0,06062665 0,07242588 ! odontogenesis GO:0042476 74 37 0,000 0,06062665 0,07239048 ! actomyosin structure organization GO:0031032 68 37 0,000 0,06062665 0,07235511 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,06062665 0,07231978 ! female gonad development GO:0008585 71 37 0,000 0,06062665 0,07228449 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,06062665 0,07224923 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,06062665 0,072214 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,06221401 0,07406863 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,06221401 0,07403256 ! meiosis I GO:0007127 74 38 0,000 0,06221401 0,07399651 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,06221401 0,0739605 ! organic anion transport GO:0015711 82 38 0,000 0,06221401 0,07392453 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,06221401 0,07388859 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,06221401 0,07385269 ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,06221401 0,07381682 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,06221401 0,07378099 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,06221401 0,07374519 ! regulation of protein stability GO:0031647 77 38 0,000 0,06221401 0,07370943 ! spermatid development GO:0007286 69 38 0,000 0,06221401 0,0736737 ! pigment metabolic process GO:0042440 87 38 0,000 0,06221401 0,073638 ! neural tube formation GO:0001841 79 38 0,000 0,06221401 0,07360234 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,06379874 0,07544062 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,06379874 0,07540412 ! negative regulation of binding GO:0051100 71 39 0,000 0,06379874 0,07536766 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,06379874 0,07533123 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,06379874 0,07529484 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,06379874 0,07525848 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,06379874 0,07522216 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,06379874 0,07518587 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,06379874 0,07514962 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,06538083 0,07697608 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,06538083 0,076939 ! learning GO:0007612 82 40 0,000 0,06538083 0,07690195 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,06538083 0,07686495 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,06538083 0,07682797 ! mismatch repair GO:0006298 58 40 0,000 0,06538083 0,07679104 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,06538083 0,07675414 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,06538083 0,07671727 ! RNA export from nucleus GO:0006405 61 41 0,000 0,06696029 0,07853287 ! mRNA catabolic process GO:0006402 79 41 0,000 0,06696029 0,07849519 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,06696029 0,07845754 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,06696029 0,07841993 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,06696029 0,07838236 ! gliogenesis GO:0042063 91 41 0,000 0,06696029 0,07834482 ! feeding behavior GO:0007631 69 41 0,000 0,06696029 0,07830731 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,06696029 0,07826985 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,06696029 0,07823241 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,06696029 0,07819502 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,06696029 0,07815766 ! spermatid differentiation GO:0048515 73 41 0,000 0,06696029 0,07812033 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,06696029 0,07808304 ! RNA modification GO:0009451 64 41 0,000 0,06696029 0,07804579 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,06853712 0,07984558 ! ear morphogenesis GO:0042471 64 42 0,000 0,06853712 0,07980752 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,06853712 0,0797695 ! T cell differentiation GO:0030217 93 42 0,000 0,06853712 0,07973152 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,06853712 0,07969357 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,06853712 0,07965565 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,06853712 0,07961778 ! regulation of protein secretion GO:0050708 77 42 0,000 0,06853712 0,07957994 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,06853712 0,07954213 ! cytokinesis GO:0000910 84 42 0,000 0,06853712 0,07950436 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,06853712 0,07946663 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,07011134 0,08125332 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 0,000 0,07011134 0,08121479 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,07011134 0,0811763 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,07011134 0,08113785 ! regulation of tube size GO:0035150 76 43 0,000 0,07011134 0,08109943 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,07011134 0,08106105 ! glucose transport GO:0015758 66 43 0,000 0,07011134 0,0810227 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,07011134 0,08098439 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,07011134 0,08094612 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,07011134 0,08090789 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,07011134 0,08086969 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,07011134 0,08083152 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,07011134 0,08079339 ! segmentation GO:0035282 78 43 0,000 0,07011134 0,0807553 ! ion transmembrane transport GO:0034220 79 43 0,000 0,07011134 0,08071724 ! neuron migration GO:0001764 85 43 0,000 0,07011134 0,08067922 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,07011134 0,08064124 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,07168293 0,08241007 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,07168293 0,08237131 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,07168293 0,08233259 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,07168293 0,08229389 ! hexose transport GO:0008645 68 44 0,000 0,07168293 0,08225524 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,07168293 0,08221662 ! striated muscle contraction GO:0006941 85 44 0,000 0,07168293 0,08217804 ! phagocytosis GO:0006909 105 44 0,000 0,07168293 0,0821395 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,07168293 0,08210099 ! double-strand break repair GO:0006302 85 44 0,000 0,07168293 0,08206252 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,07325192 0,08381941 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,07325192 0,08378017 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,07325192 0,08374097 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,07325192 0,0837018 ! biopolymer methylation GO:0043414 91 45 0,000 0,07325192 0,08366267 ! B cell differentiation GO:0030183 124 45 0,000 0,07325192 0,08362357 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,07325192 0,08358451 ! female gamete generation GO:0007292 71 45 0,000 0,07325192 0,08354549 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,07325192 0,08350651 ! polyol metabolic process GO:0019751 77 45 0,000 0,07325192 0,08346756 ! developmental growth GO:0048589 88 45 0,000 0,07325192 0,08342864 ! maintenance of location in cell GO:0051651 101 45 0,000 0,07325192 0,08338977 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,0748183 0,08513326 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,0748183 0,08509362 ! glycolysis GO:0006096 71 46 0,000 0,0748183 0,08505403 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,0748183 0,08501447 ! leukocyte migration GO:0050900 75 46 0,000 0,0748183 0,08497494 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,0748183 0,08493546 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,0748183 0,08489601 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,0748183 0,0848566 ! pigmentation GO:0043473 103 46 0,000 0,0748183 0,08481722 ! cell growth GO:0016049 90 46 0,000 0,0748183 0,08477788 ! neural tube development GO:0021915 91 47 0,000 0,07638208 0,08650969 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,07638208 0,08646961 ! positive regulation of defense response GO:0031349 88 48 0,000 0,07794325 0,08819609 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,07794325 0,08815526 ! mitochondrial transport GO:0006839 94 48 0,000 0,07794325 0,08811447 ! cellular component disassembly GO:0022411 89 48 0,000 0,07794325 0,08807371 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,07794325 0,08803299 ! endosome transport GO:0016197 127 48 0,000 0,07794325 0,08799231 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,07794325 0,08795167 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,07794325 0,08791106 ! male sex differentiation GO:0046661 93 48 0,000 0,07794325 0,0878705 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,07794325 0,08782996 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,07794325 0,08778947 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,07794325 0,08774902 ! methylation GO:0032259 97 48 0,000 0,07794325 0,0877086 ! response to calcium ion GO:0051592 94 49 0,000 0,07950183 0,08942126 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,07950183 0,08938011 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,07950183 0,089339 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,07950183 0,08929792 ! JNK cascade GO:0007254 106 49 0,000 0,07950183 0,08925688 ! regulation of action potential GO:0001508 102 50 0,000 0,08105782 0,090962 ! regulation of ion transport GO:0043269 86 50 0,000 0,08105782 0,09092023 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,08105782 0,09087851 ! endocrine system development GO:0035270 109 50 0,000 0,08105782 0,09083682 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,08105782 0,09079517 ! activation of caspase activity GO:0006919 95 50 0,000 0,08105782 0,09075356 ! regulation of ossification GO:0030278 123 50 0,000 0,08105782 0,09071198 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,08105782 0,09067045 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,08105782 0,09062895 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,08105782 0,09058749 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,08105782 0,09054607 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,08105782 0,09050469 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,08261123 0,092197 ! viral infectious cycle GO:0019058 104 51 0,000 0,08261123 0,0921549 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,08261123 0,09211284 ! peptide metabolic process GO:0006518 80 51 0,000 0,08261123 0,09207082 ! response to temperature stimulus GO:0009266 84 51 0,000 0,08261123 0,09202883 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,08261123 0,09198689 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,08261123 0,09194498 ! positive regulation of binding GO:0051099 88 52 0,000 0,08416205 0,09362836 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,08416205 0,09358575 ! Notch signaling pathway GO:0007219 111 52 0,000 0,08416205 0,09354317 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,08416205 0,09350063 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,08416205 0,09345813 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,08416205 0,09341567 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,08416205 0,09337325 ! excretion GO:0007588 87 52 0,000 0,08416205 0,09333086 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,08416205 0,09328852 ! histone modification GO:0016570 104 52 0,000 0,08416205 0,09324621 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,08416205 0,09320394 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,08416205 0,09316171 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,08416205 0,09311951 ! amino acid activation GO:0043038 98 52 0,000 0,08416205 0,09307736 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,08571029 0,09474672 ! positive regulation of growth GO:0045927 96 53 0,000 0,08571029 0,09470387 ! inner ear development GO:0048839 89 53 0,000 0,08571029 0,09466105 ! chromatin remodeling GO:0006338 122 53 0,000 0,08571029 0,09461828 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,08571029 0,09457554 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,08571029 0,09453284 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,08571029 0,09449018 ! cartilage development GO:0051216 99 53 0,000 0,08571029 0,09444756 ! synapse organization GO:0050808 102 53 0,000 0,08571029 0,09440498 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,08725596 0,09606414 ! regulation of translational initiation GO:0006446 87 54 0,000 0,08725596 0,09602087 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,08725596 0,09597763 ! neuromuscular process GO:0050905 107 54 0,000 0,08725596 0,09593444 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,08725596 0,09589128 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,08725596 0,09584817 ! covalent chromatin modification GO:0016569 115 54 0,000 0,08725596 0,09580509 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,08725596 0,09576205 ! regulation of cell shape GO:0008360 142 54 0,000 0,08725596 0,09571905 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,08725596 0,09567609 ! RNA catabolic process GO:0006401 103 55 0,000 0,08879906 0,09732441 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,08879906 0,09728077 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,08879906 0,09723717 ! cell recognition GO:0008037 98 55 0,000 0,08879906 0,0971936 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,08879906 0,09715007 ! cell maturation GO:0048469 107 55 0,000 0,08879906 0,09710659 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,08879906 0,09706314 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,0903396 0,09870288 ! glucose catabolic process GO:0006007 88 56 0,000 0,0903396 0,09865876 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,0903396 0,09861468 ! regulation of DNA replication GO:0006275 105 56 0,000 0,0903396 0,09857063 ! RNA elongation GO:0006354 90 56 0,000 0,0903396 0,09852663 ! chloride transport GO:0006821 102 57 0,000 0,09187757 0,10015927 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,09187757 0,10011459 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,09187757 0,10006996 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 105 57 0,000 0,09187757 0,10002536 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,09187757 0,09998081 ! regulation of actin filament length GO:0030832 118 58 0,000 0,09341299 0,10160638 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,09341299 0,10156116 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,09341299 0,10151599 ! aging GO:0007568 112 58 0,000 0,09341299 0,10147085 ! gastrulation GO:0007369 122 58 0,000 0,09341299 0,10142575 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,09341299 0,10138069 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,09341299 0,10133567 ! maintenance of location GO:0051235 124 58 0,000 0,09341299 0,1012907 ! nuclear export GO:0051168 110 59 0,000 0,09494586 0,10290715 ! establishment of organelle localization GO:0051656 122 59 0,000 0,09494586 0,10286152 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,09647617 0,10447309 ! DNA catabolic process GO:0006308 94 60 0,000 0,09647617 0,1044268 ! regulation of endocytosis GO:0030100 104 60 0,000 0,09647617 0,10438055 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,09647617 0,10433435 ! adult behavior GO:0030534 104 60 0,000 0,09647617 0,10428818 ! kidney development GO:0001822 133 60 0,000 0,09647617 0,10424205 ! regulation of cellular component size GO:0032535 125 61 0,000 0,09800394 0,10584599 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,09800394 0,10579922 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,09800394 0,10575249 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,09800394 0,1057058 ! regulation of heart contraction GO:0008016 123 61 0,000 0,09800394 0,10565915 ! camera-type eye development GO:0043010 126 61 0,000 0,09800394 0,10561254 ! proton transport GO:0015992 117 61 0,000 0,09800394 0,10556597 ! viral reproductive process GO:0022415 132 62 0,000 0,09952917 0,10716164 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,09952917 0,10711444 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,09952917 0,10706727 ! tRNA processing GO:0008033 102 62 0,000 0,09952917 0,10702015 ! regulation of homeostatic process GO:0032844 148 62 0,000 0,09952917 0,10697306 ! regulation of mitosis GO:0007088 112 63 0,000 0,10105187 0,10856188 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,10105187 0,10851416 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,10105187 0,10846648 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,10105187 0,10841885 ! hydrogen transport GO:0006818 121 64 0,000 0,10257203 0,11000152 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,10257203 0,10995326 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,10257203 0,10990503 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,10408966 0,11148227 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,10408966 0,11143341 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,10408966 0,1113846 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,10408966 0,11133584 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,10408966 0,11128711 ! ear development GO:0043583 114 66 0,000 0,10560478 0,1128576 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,10560478 0,11280825 ! gonad development GO:0008406 115 66 0,000 0,10560478 0,11275895 ! activation of MAPK activity GO:0000187 124 67 0,000 0,10711737 0,11432404 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,10711737 0,11427412 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,10711737 0,11422424 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,10711737 0,1141744 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,10711737 0,11412461 ! secondary metabolic process GO:0019748 125 67 0,000 0,10711737 0,11407486 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,10711737 0,11402515 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,10862744 0,11558225 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,10862744 0,11553193 ! hexose catabolic process GO:0019320 113 68 0,000 0,10862744 0,11548165 ! extracellular matrix organization GO:0030198 146 68 0,000 0,10862744 0,11543142 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,10862744 0,11538124 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,10862744 0,11533109 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,10862744 0,11528099 ! viral reproduction GO:0016032 142 68 0,000 0,10862744 0,11523093 ! adaptive immune response GO:0002250 126 68 0,000 0,10862744 0,11518092 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,10862744 0,11513095 ! cell projection assembly GO:0030031 138 68 0,000 0,10862744 0,11508102 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,11013501 0,11662758 ! lung development GO:0030324 165 69 0,000 0,11013501 0,11657705 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,11013501 0,11652656 ! urogenital system development GO:0001655 149 69 0,000 0,11013501 0,11647611 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,11013501 0,11642571 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,11013501 0,11637536 ! developmental maturation GO:0021700 128 69 0,000 0,11013501 0,11632504 ! single fertilization GO:0007338 83 69 0,000 0,11013501 0,11627477 ! cell redox homeostasis GO:0045454 114 70 0,000 0,11164006 0,11781282 ! germ cell development GO:0007281 133 70 0,000 0,11164006 0,11776195 ! activation of immune response GO:0002253 120 70 0,000 0,11164006 0,11771113 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,11164006 0,11766034 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,11314262 0,1191925 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,11314262 0,11914113 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,11314262 0,1190898 ! appendage morphogenesis GO:0035107 150 72 0,000 0,11464267 0,12061673 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,11464267 0,12056481 ! respiratory tube development GO:0030323 171 72 0,000 0,11464267 0,12051293 ! actin filament organization GO:0007015 167 72 0,000 0,11464267 0,1204611 ! B cell activation GO:0042113 179 72 0,000 0,11464267 0,12040931 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,11464267 0,12035756 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,11464267 0,12030586 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,11464267 0,12025421 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,11464267 0,1202026 ! appendage development GO:0048736 151 73 0,000 0,11614023 0,12172054 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,11614023 0,12166835 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,11614023 0,1216162 ! regulation of immune effector process GO:0002697 156 73 0,000 0,11614023 0,12156409 ! acute inflammatory response GO:0002526 118 74 0,000 0,1176353 0,12307625 ! amino acid transport GO:0006865 148 74 0,000 0,1176353 0,12302356 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,1176353 0,12297092 ! respiratory system development GO:0060541 175 74 0,000 0,1176353 0,12291832 ! organelle localization GO:0051640 155 74 0,000 0,1176353 0,12286577 ! regulation of transcription factor activity GO:0051090 137 75 0,000 0,11912788 0,12437155 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 143 75 0,000 0,11912788 0,12431842 ! reproductive structure development GO:0048608 131 75 0,000 0,11912788 0,12426534 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,11912788 0,1242123 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,11912788 0,12415931 ! eye development GO:0001654 155 75 0,000 0,11912788 0,12410636 ! axon guidance GO:0007411 162 75 0,000 0,11912788 0,12405346 ! rhythmic process GO:0048511 142 75 0,000 0,11912788 0,1240006 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,12061798 0,12549818 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,12061798 0,12544476 ! learning or memory GO:0007611 161 76 0,000 0,12061798 0,12539138 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,12061798 0,12533804 ! regulation of blood pressure GO:0008217 134 76 0,000 0,12061798 0,12528475 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,12061798 0,12523151 ! amine catabolic process GO:0009310 136 77 0,000 0,1221056 0,12672217 ! neurotransmitter transport GO:0006836 142 77 0,000 0,1221056 0,12666836 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,1221056 0,1266146 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,1221056 0,12656088 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,1221056 0,1265072 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,1221056 0,12645358 ! regulation of catabolic process GO:0009894 173 77 0,000 0,1221056 0,12639999 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,12359075 0,12788318 ! antigen processing and presentation GO:0019882 117 78 0,000 0,12359075 0,12782904 ! fertilization GO:0009566 99 78 0,000 0,12359075 0,12777495 ! blood coagulation GO:0007596 151 79 0,000 0,12507342 0,12925312 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,12507342 0,12919847 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,12507342 0,12914386 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,12507342 0,1290893 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,12507342 0,12903479 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,12507342 0,12898032 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,12655363 0,1304517 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,12655363 0,13039668 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,12655363 0,1303417 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,12655363 0,13028678 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,12803138 0,13175259 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,12950667 0,13321465 ! protein import into nucleus GO:0006606 174 82 0,000 0,12950667 0,13315858 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,1309795 0,13461629 ! exocytosis GO:0006887 153 83 0,000 0,1309795 0,13455968 ! response to drug GO:0042493 149 83 0,000 0,1309795 0,13450312 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,1309795 0,1344466 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,1309795 0,13439014 ! nuclear import GO:0051170 177 83 0,000 0,1309795 0,13433372 ! inorganic anion transport GO:0015698 156 83 0,000 0,1309795 0,13427735 ! response to metal ion GO:0010038 158 84 0,000 0,13244988 0,13572779 ! T cell activation GO:0042110 189 84 0,000 0,13244988 0,13567088 ! response to nutrient GO:0007584 135 84 0,000 0,13244988 0,13561402 ! digestion GO:0007586 130 84 0,000 0,13244988 0,13555721 ! regulation of ligase activity GO:0051340 147 84 0,000 0,13244988 0,13550044 ! hemostasis GO:0007599 165 85 0,000 0,13391782 0,13694484 ! negative regulation of transport GO:0051051 164 85 0,000 0,13391782 0,13688754 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,13391782 0,13683029 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,13391782 0,13677309 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,13391782 0,13671593 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,13391782 0,13665882 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,13538331 0,13809663 ! regulation of lyase activity GO:0051339 169 86 0,000 0,13538331 0,13803899 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,13684637 0,13947254 ! mitochondrion organization GO:0007005 159 87 0,000 0,13684637 0,13941437 ! alcohol catabolic process GO:0046164 142 87 0,000 0,13684637 0,13935626 ! nucleosome assembly GO:0006334 126 87 0,000 0,13684637 0,1392982 ! cellular respiration GO:0045333 143 88 0,000 0,13830699 0,14072635 ! amine biosynthetic process GO:0009309 146 88 0,000 0,13830699 0,14066776 ! sensory perception of smell GO:0007608 117 88 0,000 0,13830699 0,14060922 ! chromatin assembly GO:0031497 128 88 0,000 0,13830699 0,14055073 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,13830699 0,14049229 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,13976518 0,14191452 ! regulation of DNA binding GO:0051101 167 89 0,000 0,13976518 0,14185556 ! tube morphogenesis GO:0035239 194 89 0,000 0,13976518 0,14179665 ! cellular defense response GO:0006968 123 89 0,000 0,13976518 0,14173778 ! protein localization in nucleus GO:0034504 192 89 0,000 0,13976518 0,14167897 ! regulation of neurological system process GO:0031644 175 89 0,000 0,13976518 0,14162021 ! response to inorganic substance GO:0010035 173 90 0,000 0,14122094 0,14303597 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,14122094 0,14297669 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,14122094 0,14291746 ! response to unfolded protein GO:0006986 139 90 0,000 0,14122094 0,14285828 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,14122094 0,14279915 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,14267428 0,14420905 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,14267428 0,14414941 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,1441252 0,14555513 ! regulation of cell adhesion GO:0030155 241 92 0,000 0,1441252 0,14549499 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,14557371 0,14689656 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,14557371 0,14683591 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,14557371 0,14677531 ! vitamin metabolic process GO:0006766 153 93 0,000 0,14557371 0,14671476 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,14701981 0,14811109 ! female pregnancy GO:0007565 166 94 0,000 0,14701981 0,14805004 ! sterol metabolic process GO:0016125 166 94 0,000 0,14701981 0,14798903 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,14701981 0,14792808 ! nucleosome organization GO:0034728 143 95 0,000 0,1484635 0,14931919 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,1484635 0,14925775 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,1484635 0,14919635 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,1484635 0,149135 ! sex differentiation GO:0007548 171 96 0,000 0,14990478 0,15052091 ! response to protein stimulus GO:0051789 158 96 0,000 0,14990478 0,15045907 ! regulation of T cell activation GO:0050863 175 96 0,000 0,14990478 0,15039728 ! regulation of DNA metabolic process GO:0051052 188 97 0,000 0,15134367 0,15177857 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,15134367 0,15171629 ! transcription initiation GO:0006352 171 97 0,000 0,15134367 0,15165406 ! leukocyte differentiation GO:0002521 232 98 0,000 0,15278016 0,15303073 ! forebrain development GO:0030900 210 98 0,000 0,15278016 0,15296801 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,15278016 0,15290534 ! positive regulation of immune response GO:0050778 175 100 0,000 0,15564598 0,15570972 ! hormone metabolic process GO:0042445 171 100 0,000 0,15564598 0,15564598