pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1286-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 4,000 2,164E-10 5,287E-07 ! protein sumoylation GO:0016925 17 10 3,000 2,915E-08 3,561E-05 ! Notch receptor processing GO:0007220 11 5 2,000 4,123E-07 3,357E-04 ! positive regulation of protein complex assembly GO:0031334 34 18 3,000 4,157E-07 2,539E-04 ! myoblast cell fate commitment GO:0048625 18 6 2,000 8,225E-07 4,019E-04 ! amyloid precursor protein catabolic process GO:0042987 15 7 2,000 1,436E-06 5,846E-04 ! positive regulation of insulin secretion GO:0032024 17 8 2,000 2,291E-06 7,996E-04 ! amyloid precursor protein metabolic process GO:0042982 18 9 2,000 3,428E-06 1,047E-03 ! negative regulation of transcription regulator activity GO:0090048 57 30 3,000 3,604E-06 9,783E-04 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of peptide secretion GO:0002793 24 11 2,000 6,699E-06 1,637E-03 ! negative regulation of DNA binding GO:0043392 67 36 3,000 7,622E-06 1,693E-03 ! androgen receptor signaling pathway GO:0030521 81 37 3,000 8,523E-06 1,735E-03 ! focal adhesion formation GO:0048041 37 12 2,000 8,91E-06 1,674E-03 ! regulation of hormone metabolic process GO:0032350 28 12 2,000 8,91E-06 1,555E-03 ! negative regulation of binding GO:0051100 71 39 3,000 1,056E-05 1,72E-03 ! membrane protein proteolysis GO:0033619 33 13 2,000 1,155E-05 1,764E-03 GO:0006509|membrane protein ectodomain proteolysis, ! mesenchymal cell development GO:0014031 94 41 3,000 1,293E-05 1,858E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! catecholamine biosynthetic process GO:0042423 30 14 2,000 1,467E-05 1,991E-03 ! glycoprotein catabolic process GO:0006516 33 15 2,000 1,829E-05 2,351E-03 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 1,829E-05 2,234E-03 ! fructose metabolic process GO:0006000 25 16 2,000 2,245E-05 2,612E-03 ! regulation of protein localization GO:0032880 188 97 4,000 2,376E-05 2,638E-03 ! myoblast differentiation GO:0045445 50 17 2,000 2,719E-05 2,888E-03 ! DNA unwinding during replication GO:0006268 26 17 2,000 2,719E-05 2,768E-03 ! cell-substrate junction assembly GO:0007044 56 18 2,000 3,254E-05 3,18E-03 ! positive regulation of hormone secretion GO:0046887 35 19 2,000 3,855E-05 3,622E-03 ! regulation of translational initiation GO:0006446 87 54 3,000 3,899E-05 3,528E-03 ! pancreas development GO:0031016 40 20 2,000 4,524E-05 3,947E-03 ! DNA duplex unwinding GO:0032508 30 20 2,000 4,524E-05 3,811E-03 GO:0032392|DNA geometric change, ! regulation of cell-matrix adhesion GO:0001952 81 23 2,000 6,974E-05 5,679E-03 GO:0010810|regulation of cell-substrate adhesion, ! regulation of protein complex assembly GO:0043254 132 63 3,000 7,167E-05 5,648E-03 ! steroid hormone receptor signaling pathway GO:0030518 146 66 3,000 8,602E-05 6,567E-03 ! regulation of insulin secretion GO:0050796 42 25 2,000 9,011E-05 6,671E-03 ! chromosome segregation GO:0007059 127 67 3,000 9,124E-05 6,556E-03 ! molting cycle process GO:0022404 52 26 2,000 1,016E-04 7,092E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! urogenital system development GO:0001655 149 69 3,000 1,024E-04 6,946E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 1,144E-04 7,555E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 1,199E-04 7,708E-03 GO:0045844|positive regulation of striated muscle development, ! regulation of mitochondrial membrane permeability GO:0046902 15 5 1,000 1,199E-04 7,511E-03 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 1,000 1,199E-04 7,323E-03 ! anagen GO:0042640 7 5 1,000 1,199E-04 7,144E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 1,199E-04 6,974E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 1,199E-04 6,812E-03 ! mitotic recombination GO:0006312 9 5 1,000 1,199E-04 6,657E-03 ! B cell homeostasis GO:0001782 13 5 1,000 1,199E-04 6,509E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 1,199E-04 6,368E-03 ! regulation of sensory perception GO:0051931 8 5 1,000 1,199E-04 6,232E-03 GO:0051930|regulation of sensory perception of pain, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 1,199E-04 6,102E-03 ! actin filament organization GO:0007015 167 72 3,000 1,208E-04 6,024E-03 ! fat cell differentiation GO:0045444 57 28 2,000 1,274E-04 6,223E-03 ! regulation of transcription factor activity GO:0051090 137 75 3,000 1,416E-04 6,783E-03 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 3,000 1,416E-04 6,653E-03 ! catechol metabolic process GO:0009712 55 29 2,000 1,417E-04 6,532E-03 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! regulation of peptide secretion GO:0002791 52 29 2,000 1,417E-04 6,411E-03 ! phenol metabolic process GO:0018958 56 30 2,000 1,57E-04 6,976E-03 ! cell junction assembly GO:0034329 85 31 2,000 1,734E-04 7,566E-03 ! male gonad development GO:0008584 56 31 2,000 1,734E-04 7,433E-03 ! neural nucleus development GO:0048857 19 6 1,000 1,794E-04 7,558E-03 ! hair follicle maturation GO:0048820 8 6 1,000 1,794E-04 7,43E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 1,794E-04 7,306E-03 ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 1,794E-04 7,186E-03 ! metanephros development GO:0001656 81 32 2,000 1,909E-04 7,522E-03 ! biogenic amine biosynthetic process GO:0042401 65 35 2,000 2,5E-04 9,693E-03 ! prostate gland development GO:0030850 14 7 1,000 2,506E-04 9,567E-03 ! organ growth GO:0035265 15 7 1,000 2,506E-04 9,42E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 2,506E-04 9,278E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 2,506E-04 9,139E-03 ! peptidyl-threonine modification GO:0018210 26 7 1,000 2,506E-04 9,005E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 2,506E-04 8,874E-03 ! regulation of DNA binding GO:0051101 167 89 3,000 2,74E-04 9,561E-03 ! cell junction organization GO:0034330 96 37 2,000 2,952E-04 0,01015903 ! male meiosis GO:0007140 9 8 1,000 3,334E-04 0,01131331 ! prostaglandin biosynthetic process GO:0001516 15 8 1,000 3,334E-04 0,01115833 GO:0046457|prostanoid biosynthetic process, ! pigment granule organization GO:0048753 17 8 1,000 3,334E-04 0,01100754 ! regulation of pigmentation during development GO:0048070 25 8 1,000 3,334E-04 0,01086078 ! melanin metabolic process GO:0006582 17 8 1,000 3,334E-04 0,01071787 ! response to UV-B GO:0010224 17 8 1,000 3,334E-04 0,01057868 ! carbohydrate homeostasis GO:0033500 59 39 2,000 3,455E-04 0,01082142 GO:0042593|glucose homeostasis, ! sex differentiation GO:0007548 171 96 3,000 3,658E-04 0,0113123 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 3,957E-04 0,01208219 ! regulation of hormone secretion GO:0046883 69 41 2,000 4,01E-04 0,01209328 ! T cell selection GO:0045058 27 9 1,000 4,277E-04 0,01274264 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 4,277E-04 0,01258911 ! development of primary male sexual characteristics GO:0046546 80 43 2,000 4,618E-04 0,01343183 ! response to reactive oxygen species GO:0000302 75 44 2,000 4,944E-04 0,0142089 ! developmental growth GO:0048589 88 45 2,000 5,283E-04 0,01500862 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 5,334E-04 0,01497859 ! B cell proliferation GO:0042100 19 10 1,000 5,334E-04 0,01480838 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 5,334E-04 0,01464199 ! response to nicotine GO:0035094 20 10 1,000 5,334E-04 0,0144793 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 5,638E-04 0,01513505 ! male sex differentiation GO:0046661 93 48 2,000 6,391E-04 0,01697092 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 1,000 6,505E-04 0,01708695 ! behavioral fear response GO:0001662 27 11 1,000 6,505E-04 0,01690517 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 6,505E-04 0,01672722 ! alpha-beta T cell activation GO:0046631 26 11 1,000 6,505E-04 0,01655298 ! DNA methylation GO:0006306 19 11 1,000 6,505E-04 0,01638233 GO:0006305|DNA alkylation, ! thymus development GO:0048538 29 11 1,000 6,505E-04 0,01621516 ! oocyte development GO:0048599 20 11 1,000 6,505E-04 0,01605137 ! sequestering of metal ion GO:0051238 15 11 1,000 6,505E-04 0,01589086 ! regulation of ossification GO:0030278 123 50 2,000 7,206E-04 0,01742917 ! T cell homeostasis GO:0043029 28 12 1,000 7,788E-04 0,01865245 ! oocyte differentiation GO:0009994 21 12 1,000 7,788E-04 0,01847136 ! Notch signaling pathway GO:0007219 111 52 2,000 8,084E-04 0,01898874 ! DNA-dependent DNA replication GO:0006261 82 52 2,000 8,084E-04 0,0188079 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 9,183E-04 0,02116355 GO:0000725|recombinational repair, ! pseudouridine synthesis GO:0001522 19 13 1,000 9,183E-04 0,02096576 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 9,183E-04 0,02077163 ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 9,183E-04 0,02058107 ! gland morphogenesis GO:0022612 31 13 1,000 9,183E-04 0,02039397 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 9,183E-04 0,02021024 ! spleen development GO:0048536 24 13 1,000 9,183E-04 0,02002979 ! digestive tract morphogenesis GO:0048546 31 13 1,000 9,183E-04 0,01985254 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! skeletal muscle fiber development GO:0048741 130 56 2,000 1,004E-03 0,0215089 ! regulation of bone remodeling GO:0046850 143 57 2,000 1,057E-03 0,0224494 ! muscle fiber development GO:0048747 131 57 2,000 1,057E-03 0,02225588 ! hair follicle morphogenesis GO:0031069 27 14 1,000 1,069E-03 0,02231841 ! fear response GO:0042596 34 14 1,000 1,069E-03 0,02212927 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 1,069E-03 0,02194331 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 37 14 1,000 1,069E-03 0,02176045 ! response to gamma radiation GO:0010332 30 14 1,000 1,069E-03 0,02158061 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 1,069E-03 0,02140372 ! regulation of tissue remodeling GO:0034103 146 58 2,000 1,112E-03 0,0220781 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 2,000 1,112E-03 0,02190005 ! kidney development GO:0001822 133 60 2,000 1,227E-03 0,02397149 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 1,231E-03 0,02385804 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 1,231E-03 0,02367018 ! muscle maintenance GO:0046716 26 15 1,000 1,231E-03 0,02348526 ! lymphocyte homeostasis GO:0002260 33 15 1,000 1,231E-03 0,0233032 ! positive regulation of secretion GO:0051047 110 61 2,000 1,287E-03 0,02418036 ! regulation of homeostatic process GO:0032844 148 62 2,000 1,349E-03 0,02515208 ! startle response GO:0001964 28 16 1,000 1,403E-03 0,0259676 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 1,000 1,403E-03 0,02577235 ! DNA replication initiation GO:0006270 28 16 1,000 1,403E-03 0,02558002 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 1,403E-03 0,02539054 ! regulation of mitosis GO:0007088 112 63 2,000 1,413E-03 0,02537437 GO:0051783|regulation of nuclear division, ! response to peptide hormone stimulus GO:0043434 129 64 2,000 1,478E-03 0,0263611 ! metencephalon development GO:0022037 32 17 1,000 1,587E-03 0,02808621 ! regulation of striated muscle contraction GO:0006942 23 17 1,000 1,587E-03 0,02788415 ! regulation of protein binding GO:0043393 33 17 1,000 1,587E-03 0,02768497 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 1,587E-03 0,02748863 ! gonad development GO:0008406 115 66 2,000 1,615E-03 0,02779207 ! regulation of viral genome replication GO:0045069 30 18 1,000 1,781E-03 0,03042269 ! epidermis morphogenesis GO:0048730 43 18 1,000 1,781E-03 0,03021142 ! defense response to virus GO:0051607 43 18 1,000 1,781E-03 0,03000307 ! germ cell development GO:0007281 133 70 2,000 1,913E-03 0,03200938 ! protein maturation by peptide bond cleavage GO:0051605 118 70 2,000 1,913E-03 0,03179163 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 1,986E-03 0,03277826 ! mitotic chromosome condensation GO:0007076 37 19 1,000 1,986E-03 0,03255827 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 1,986E-03 0,03234122 ! cellular pigmentation GO:0033059 37 19 1,000 1,986E-03 0,03212704 ! response to alkaloid GO:0043279 38 20 1,000 2,201E-03 0,03538108 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 2,201E-03 0,03514983 ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 2,201E-03 0,03492159 ! actin filament bundle formation GO:0051017 47 20 1,000 2,201E-03 0,03469629 ! cell-matrix adhesion GO:0007160 181 76 2,000 2,42E-03 0,03789349 ! ovarian follicle development GO:0001541 39 21 1,000 2,428E-03 0,03777379 ! prostaglandin metabolic process GO:0006693 43 21 1,000 2,428E-03 0,03753472 GO:0006692|prostanoid metabolic process, ! reciprocal meiotic recombination GO:0007131 44 22 1,000 2,664E-03 0,0409351 ! ureteric bud development GO:0001657 50 22 1,000 2,664E-03 0,04067926 ! cell aging GO:0007569 48 22 1,000 2,664E-03 0,04042659 ! renal system process GO:0003014 42 22 1,000 2,664E-03 0,04017704 ! G1 phase GO:0051318 44 22 1,000 2,664E-03 0,03993056 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 2,664E-03 0,03968708 ! peptidyl-serine modification GO:0018209 50 22 1,000 2,664E-03 0,03944655 ! response to cytokine stimulus GO:0034097 69 22 1,000 2,664E-03 0,03920892 ! gut development GO:0048565 44 22 1,000 2,664E-03 0,03897414 ! protein oligomerization GO:0051259 149 79 2,000 2,701E-03 0,03928189 ! development of primary sexual characteristics GO:0045137 143 80 2,000 2,799E-03 0,04046846 ! meiosis GO:0007126 143 81 2,000 2,9E-03 0,04167232 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 2,000 2,9E-03 0,04142862 ! regeneration GO:0031099 42 23 1,000 2,911E-03 0,04135075 ! regulation of DNA recombination GO:0000018 51 23 1,000 2,911E-03 0,04111173 ! response to ethanol GO:0045471 47 23 1,000 2,911E-03 0,04087546 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 2,911E-03 0,04064188 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 2,911E-03 0,04041096 ! DNA modification GO:0006304 36 23 1,000 2,911E-03 0,04018265 ! cell-substrate adhesion GO:0031589 189 82 2,000 3,002E-03 0,04120655 ! meiotic cell cycle GO:0051321 144 82 2,000 3,002E-03 0,04097634 ! response to drug GO:0042493 149 83 2,000 3,107E-03 0,04217012 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 3,169E-03 0,04276933 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 3,169E-03 0,04253434 ! sex determination GO:0007530 48 24 1,000 3,169E-03 0,04230191 ! regulation of viral reproduction GO:0050792 41 24 1,000 3,169E-03 0,04207201 ! oogenesis GO:0048477 44 24 1,000 3,169E-03 0,04184459 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 3,436E-03 0,0451358 ! vasculogenesis GO:0001570 49 25 1,000 3,436E-03 0,04489444 ! chromosome condensation GO:0030261 48 25 1,000 3,436E-03 0,04465564 ! lymphocyte proliferation GO:0046651 55 25 1,000 3,436E-03 0,04441936 ! leukocyte homeostasis GO:0001776 50 25 1,000 3,436E-03 0,04418558 ! amine biosynthetic process GO:0009309 146 88 2,000 3,664E-03 0,04686897 ! multicellular organismal response to stress GO:0033555 61 26 1,000 3,714E-03 0,04726135 ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 3,714E-03 0,04701648 ! regulation of cell cycle process GO:0010564 161 90 2,000 3,903E-03 0,0491519 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 4,002E-03 0,05014273 ! response to toxin GO:0009636 49 27 1,000 4,002E-03 0,0498869 ! leukocyte proliferation GO:0070661 59 27 1,000 4,002E-03 0,04963367 GO:0032943|mononuclear cell proliferation, ! mitochondrial membrane organization GO:0007006 60 27 1,000 4,002E-03 0,04938299 ! cellular response to oxidative stress GO:0034599 43 27 1,000 4,002E-03 0,04913484 ! gland development GO:0048732 220 91 2,000 4,026E-03 0,04917849 ! regulation of cell adhesion GO:0030155 241 92 2,000 4,151E-03 0,05045586 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 4,3E-03 0,05201009 ! regulation of membrane potential GO:0042391 179 94 2,000 4,409E-03 0,05305769 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 4,609E-03 0,05518931 ! response to organic cyclic substance GO:0014070 58 29 1,000 4,609E-03 0,0549201 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 4,609E-03 0,05465349 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 4,813E-03 0,05680127 ! biogenic amine metabolic process GO:0006576 162 97 2,000 4,813E-03 0,05652819 ! icosanoid biosynthetic process GO:0046456 60 30 1,000 4,926E-03 0,05758566 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 4,926E-03 0,05731144 ! tissue homeostasis GO:0001894 50 30 1,000 4,926E-03 0,05703982 GO:0048871|multicellular organismal homeostasis, ! skeletal muscle tissue development GO:0007519 223 100 2,000 5,239E-03 0,06036773 GO:0060538|skeletal muscle organ development, ! ovulation cycle process GO:0022602 55 31 1,000 5,254E-03 0,0602639 ! response to heat GO:0009408 54 31 1,000 5,254E-03 0,05998229 ! iron ion homeostasis GO:0055072 60 31 1,000 5,254E-03 0,0597033 ! ovulation cycle GO:0042698 57 32 1,000 5,592E-03 0,06324476 ! hindbrain development GO:0030902 65 32 1,000 5,592E-03 0,06295331 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 1,000 5,939E-03 0,06655598 ! response to ionizing radiation GO:0010212 74 33 1,000 5,939E-03 0,06625207 ! response to hydrogen peroxide GO:0042542 56 34 1,000 6,296E-03 0,06991384 ! post-embryonic development GO:0009791 76 34 1,000 6,296E-03 0,06959749 ! adult locomotory behavior GO:0008344 62 34 1,000 6,296E-03 0,06928399 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 6,662E-03 0,07298753 ! regulation of muscle development GO:0048634 82 36 1,000 7,038E-03 0,07676141 ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 7,038E-03 0,07642025 ! positive regulation of cell development GO:0010720 85 36 1,000 7,038E-03 0,0760821 ! sister chromatid segregation GO:0000819 65 37 1,000 7,424E-03 0,07989377 ! female gonad development GO:0008585 71 37 1,000 7,424E-03 0,07954335 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 7,818E-03 0,08340628 ! meiosis I GO:0007127 74 38 1,000 7,818E-03 0,08304364 ! regulation of protein stability GO:0031647 77 38 1,000 7,818E-03 0,08268415 ! glycogen metabolic process GO:0005977 63 38 1,000 7,818E-03 0,08232775 ! pigment metabolic process GO:0042440 87 38 1,000 7,818E-03 0,08197441 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 7,818E-03 0,08162409 ! glucan metabolic process GO:0044042 64 39 1,000 8,222E-03 0,08547595 GO:0006073|cellular glucan metabolic process, ! development of primary female sexual characteristics GO:0046545 80 40 1,000 8,635E-03 0,08939044 GO:0046660|female sex differentiation, ! gliogenesis GO:0042063 91 41 1,000 9,058E-03 0,0933661 ! RNA modification GO:0009451 64 41 1,000 9,058E-03 0,0929738 ! T cell differentiation GO:0030217 93 42 1,000 9,489E-03 0,0969939 ! epithelial cell differentiation GO:0030855 83 43 1,000 9,929E-03 0,10107213 ! glucose transport GO:0015758 66 43 1,000 9,929E-03 0,10065274 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 9,929E-03 0,10023682 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,0103786 0,10434119 ! hexose transport GO:0008645 68 44 1,000 0,0103786 0,10391356 GO:0015749|monosaccharide transport, ! double-strand break repair GO:0006302 85 44 1,000 0,0103786 0,10348942 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 0,01083675 0,10761859 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 0,01083675 0,10718288 ! induction of apoptosis by intracellular signals GO:0008629 95 45 1,000 0,01083675 0,10675069 ! biopolymer methylation GO:0043414 91 45 1,000 0,01083675 0,10632198 ! B cell differentiation GO:0030183 124 45 1,000 0,01083675 0,10589669 ! female gamete generation GO:0007292 71 45 1,000 0,01083675 0,10547479 ! maintenance of location in cell GO:0051651 101 45 1,000 0,01083675 0,10505624 ! glycolysis GO:0006096 71 46 1,000 0,0113037 0,10914996 ! pigmentation GO:0043473 103 46 1,000 0,0113037 0,10872023 ! cell growth GO:0016049 90 46 1,000 0,0113037 0,10829388 ! negative regulation of cell migration GO:0030336 122 46 1,000 0,0113037 0,10787086 ! response to insulin stimulus GO:0032868 98 47 1,000 0,01177939 0,11197296 ! mitochondrial transport GO:0006839 94 48 1,000 0,01226375 0,11612536 ! icosanoid metabolic process GO:0006690 92 48 1,000 0,01226375 0,115677 ! regulation of inflammatory response GO:0050727 84 48 1,000 0,01226375 0,11523209 ! methylation GO:0032259 97 48 1,000 0,01226375 0,11479058 ! protein homooligomerization GO:0051260 84 49 1,000 0,01275672 0,11894907 ! regulation of action potential GO:0001508 102 50 1,000 0,01325822 0,12315527 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,01325822 0,12268878 ! response to temperature stimulus GO:0009266 84 51 1,000 0,0137682 0,12692726 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,0142866 0,13121112 ! unsaturated fatty acid metabolic process GO:0033559 98 52 1,000 0,0142866 0,1307197 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 1,000 0,0142866 0,13023194 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,0142866 0,1297478 ! positive regulation of growth GO:0045927 96 53 1,000 0,01481334 0,13403329 ! vesicle organization GO:0016050 127 53 1,000 0,01481334 0,1335387 ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,01481334 0,13304775 ! neuromuscular process GO:0050905 107 54 1,000 0,01534837 0,13734819 ! regulation of muscle contraction GO:0006937 94 54 1,000 0,01534837 0,13684692 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,01534837 0,13634929 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,01589161 0,14066379 ! response to UV GO:0009411 120 55 1,000 0,01589161 0,14015598 ! negative regulation of cell motion GO:0051271 142 55 1,000 0,01589161 0,13965182 ! glucose catabolic process GO:0006007 88 56 1,000 0,01644302 0,14397953 ! RNA elongation GO:0006354 90 56 1,000 0,01644302 0,14346531 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 1,000 0,01700252 0,14781903 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01732286 0,15006998 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01732286 0,1495397 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01732286 0,14901315 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01732286 0,1484903 ! neuron fate determination GO:0048664 7 5 0,000 0,01732286 0,1479711 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01732286 0,14745552 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01732286 0,14694352 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01732286 0,14643507 ! polyol transport GO:0015791 12 5 0,000 0,01732286 0,14593012 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01732286 0,14542864 ! response to superoxide GO:0000303 10 5 0,000 0,01732286 0,1449306 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01732286 0,14443596 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01732286 0,14394468 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01732286 0,14345673 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01732286 0,14297208 ! female meiosis GO:0007143 10 5 0,000 0,01732286 0,14249069 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01732286 0,14201253 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01732286 0,14153758 ! hypothalamus development GO:0021854 9 5 0,000 0,01732286 0,14106578 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01732286 0,14059713 ! cobalt ion transport GO:0006824 11 5 0,000 0,01732286 0,14013157 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01732286 0,13966909 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01732286 0,13920966 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01732286 0,13875323 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01732286 0,13829979 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01732286 0,1378493 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01732286 0,13740174 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01732286 0,13695707 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01732286 0,13651527 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01732286 0,13607632 ! transposition GO:0032196 9 5 0,000 0,01732286 0,13564018 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01732286 0,13520682 ! negative chemotaxis GO:0050919 16 5 0,000 0,01732286 0,13477623 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01732286 0,13434837 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01732286 0,13392321 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01732286 0,13350074 ! behavioral response to pain GO:0048266 10 5 0,000 0,01732286 0,13308093 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01732286 0,13266375 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01732286 0,13224917 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01732286 0,13183718 ! micturition GO:0060073 9 5 0,000 0,01732286 0,13142775 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01732286 0,13102085 ! copulation GO:0007620 9 5 0,000 0,01732286 0,13061647 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01732286 0,13021457 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01732286 0,12981514 ! bioluminescence GO:0008218 9 5 0,000 0,01732286 0,12941815 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01732286 0,12902358 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01732286 0,12863141 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01732286 0,12824162 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01732286 0,12785418 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01732286 0,12746908 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01732286 0,12708629 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01732286 0,12670579 ! grooming behavior GO:0007625 6 5 0,000 0,01732286 0,12632757 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01732286 0,12595159 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01732286 0,12557785 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01732286 0,12520632 ! response to protozoan GO:0001562 13 5 0,000 0,01732286 0,12483698 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,01732286 0,12446981 ! lymph vessel development GO:0001945 10 5 0,000 0,01732286 0,1241048 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01732286 0,12374192 ! endochondral ossification GO:0001958 17 5 0,000 0,01732286 0,12338115 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01732286 0,12302249 ! single strand break repair GO:0000012 8 5 0,000 0,01732286 0,1226659 ! parathyroid gland development GO:0060017 14 5 0,000 0,01732286 0,12231137 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01732286 0,12195889 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01732286 0,12160843 ! cytokine secretion GO:0050663 15 5 0,000 0,01732286 0,12125999 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01732286 0,12091353 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01732286 0,12056905 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01732286 0,12022652 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01732286 0,11988594 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01732286 0,11954727 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01732286 0,11921052 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01732286 0,11887566 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01732286 0,11854268 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01732286 0,11821155 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01732286 0,11788227 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01732286 0,11755482 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01732286 0,11722918 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01732286 0,11690535 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01732286 0,11658329 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01732286 0,11626301 ! microvillus organization GO:0032528 8 5 0,000 0,01732286 0,11594448 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01732286 0,11562769 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01732286 0,11531263 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01732286 0,11499928 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01732286 0,11468763 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01732286 0,11437766 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01732286 0,11406937 ! polyol catabolic process GO:0046174 9 5 0,000 0,01732286 0,11376273 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01732286 0,11345774 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01732286 0,11315437 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01732286 0,11285263 ! muscle cell migration GO:0014812 8 5 0,000 0,01732286 0,11255249 ! mitochondrial fission GO:0000266 8 5 0,000 0,01732286 0,11225394 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01732286 0,11195697 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01732286 0,11166157 ! mRNA transcription GO:0009299 10 5 0,000 0,01732286 0,11136772 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01732286 0,11107542 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01732286 0,11078465 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01732286 0,11049539 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01732286 0,11020764 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01732286 0,10992139 ! monocyte activation GO:0042117 10 5 0,000 0,01732286 0,10963662 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01732286 0,10935332 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01732286 0,10907148 ! response to food GO:0032094 6 5 0,000 0,01732286 0,10879109 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01732286 0,10851214 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01732286 0,10823462 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01732286 0,10795851 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01732286 0,1076838 ! regulation of phospholipase A2 activity GO:0032429 15 5 0,000 0,01732286 0,1074105 ! forebrain neuron development GO:0021884 13 5 0,000 0,01732286 0,10713857 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01732286 0,10686802 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01732286 0,10659883 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01732286 0,10633099 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01732286 0,1060645 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01732286 0,10579934 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01732286 0,1055355 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01732286 0,10527297 ! lipid glycosylation GO:0030259 7 5 0,000 0,01732286 0,10501175 ! nucleobase transport GO:0015851 6 5 0,000 0,01732286 0,10475182 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01732286 0,10449317 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01732286 0,1042358 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01732286 0,10397969 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01732286 0,10372484 ! basic amino acid transport GO:0015802 12 5 0,000 0,01732286 0,10347124 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01732286 0,10321887 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01732286 0,10296773 ! actin nucleation GO:0045010 11 5 0,000 0,01732286 0,1027178 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01732286 0,10246909 ! depurination GO:0045007 5 5 0,000 0,01732286 0,10222158 ! depyrimidination GO:0045008 10 5 0,000 0,01732286 0,10197527 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01732286 0,10173013 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01732286 0,10148618 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01732286 0,10124339 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01732286 0,10100175 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01732286 0,10076127 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01732286 0,10052194 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01732286 0,10028373 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01732286 0,10004666 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01732286 0,0998107 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01732286 0,09957585 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01732286 0,0993421 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01732286 0,09910945 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01732286 0,09887789 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01732286 0,0986474 ! response to arsenic GO:0046685 11 5 0,000 0,01732286 0,09841799 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01732286 0,09818964 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01732286 0,09796235 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01732286 0,09773611 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01732286 0,09751091 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01732286 0,09728675 ! response to mercury ion GO:0046689 8 5 0,000 0,01732286 0,09706361 ! response to cadmium ion GO:0046686 7 5 0,000 0,01732286 0,0968415 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01732286 0,0966204 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01732286 0,09640031 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01732286 0,09618122 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01732286 0,09596312 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01732286 0,09574601 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01732286 0,09552988 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01732286 0,09531472 ! decidualization GO:0046697 11 5 0,000 0,01732286 0,09510053 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01732286 0,0948873 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01732286 0,09467502 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01732286 0,09446369 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01732286 0,09425331 ! embryonic cleavage GO:0040016 6 5 0,000 0,01732286 0,09404386 ! peroxisome fission GO:0016559 5 5 0,000 0,01732286 0,09383533 ! histone demethylation GO:0016577 13 5 0,000 0,01732286 0,09362773 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01732286 0,09342105 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01732286 0,09321528 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01732286 0,09301041 ! metaphase plate congression GO:0051310 7 5 0,000 0,01732286 0,09280644 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01732286 0,09260336 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01732286 0,09240117 ! enteric nervous system development GO:0048484 8 5 0,000 0,01732286 0,09219986 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01732286 0,09199942 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01732286 0,09179986 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01732286 0,09160116 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01732286 0,09140332 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01732286 0,09120633 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01732286 0,09101018 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01732286 0,09081488 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01732286 0,09062042 ! metaphase GO:0051323 11 5 0,000 0,01732286 0,09042678 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01732286 0,09023398 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01732286 0,09004199 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01732286 0,08985082 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01732286 0,08966046 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01732286 0,0894709 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01732286 0,08928214 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01732286 0,08909418 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01732286 0,08890701 ! response to redox state GO:0051775 6 5 0,000 0,01732286 0,08872062 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01732286 0,08853501 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01732286 0,08835018 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01732286 0,08816611 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01732286 0,08798282 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01732286 0,08780028 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01732286 0,0876185 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01732286 0,08743747 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01732286 0,08725719 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01732286 0,08707764 ! striatum development GO:0021756 14 5 0,000 0,01732286 0,08689884 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01732286 0,08672077 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01732286 0,08654343 ! glial cell migration GO:0008347 10 5 0,000 0,01732286 0,08636681 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01732286 0,08619091 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01732286 0,08601572 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01732286 0,08584125 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01732286 0,08566748 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01732286 0,08549441 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01732286 0,08532205 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01732286 0,08515037 ! neuroprotection GO:0043526 8 5 0,000 0,01732286 0,08497939 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01732286 0,08480909 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01732286 0,08463947 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01732286 0,08447053 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01732286 0,08430226 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01732286 0,08413466 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01732286 0,08396773 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01732286 0,08380146 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01732286 0,08363584 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 0,000 0,01732286 0,08347088 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01732286 0,08330657 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01732286 0,0831429 ! spindle assembly GO:0051225 6 5 0,000 0,01732286 0,08297987 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01732286 0,08281749 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01732286 0,08265573 ! protein palmitoylation GO:0018345 12 5 0,000 0,01732286 0,08249461 ! drug metabolic process GO:0017144 7 5 0,000 0,01732286 0,08233412 ! stem cell division GO:0017145 11 5 0,000 0,01732286 0,08217424 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01732286 0,08201499 ! organ regeneration GO:0031100 7 5 0,000 0,01732286 0,08185635 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01732286 0,08169833 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01732286 0,08154092 ! positive regulation of cell migration GO:0030335 137 58 1,000 0,01757005 0,08254544 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,01757005 0,08238701 ! aging GO:0007568 112 58 1,000 0,01757005 0,08222918 ! maintenance of location GO:0051235 124 58 1,000 0,01757005 0,08207195 ! adult behavior GO:0030534 104 60 1,000 0,01872897 0,08731845 ! regulation of heart contraction GO:0008016 123 61 1,000 0,01932023 0,08990347 ! camera-type eye development GO:0043010 126 61 1,000 0,01932023 0,08973255 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02075154 0,09619736 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02075154 0,09601517 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02075154 0,09583366 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02075154 0,09565284 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02075154 0,09547271 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02075154 0,09529325 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02075154 0,09511446 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02075154 0,09493634 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02075154 0,09475889 ! response to oxygen radical GO:0000305 11 6 0,000 0,02075154 0,0945821 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02075154 0,09440597 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02075154 0,0942305 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02075154 0,09405567 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02075154 0,0938815 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02075154 0,09370796 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02075154 0,09353507 ! forebrain regionalization GO:0021871 9 6 0,000 0,02075154 0,09336281 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02075154 0,09319119 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02075154 0,0930202 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02075154 0,09284983 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02075154 0,09268009 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02075154 0,09251096 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02075154 0,09234246 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02075154 0,09217456 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02075154 0,09200727 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02075154 0,09184059 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02075154 0,09167452 ! malate metabolic process GO:0006108 13 6 0,000 0,02075154 0,09150904 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02075154 0,09134416 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02075154 0,09117987 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02075154 0,09101617 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02075154 0,09085306 ! protein refolding GO:0042026 15 6 0,000 0,02075154 0,09069053 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02075154 0,09052859 ! opsonization GO:0008228 8 6 0,000 0,02075154 0,09036722 ! mating behavior GO:0007617 7 6 0,000 0,02075154 0,09020642 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02075154 0,0900462 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02075154 0,08988654 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02075154 0,08972745 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02075154 0,08956892 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02075154 0,08941095 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02075154 0,08925353 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02075154 0,08909667 ! toxin metabolic process GO:0009404 11 6 0,000 0,02075154 0,08894036 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02075154 0,0887846 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02075154 0,08862938 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02075154 0,08847471 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02075154 0,08832057 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,02075154 0,08816697 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02075154 0,0880139 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02075154 0,08786137 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02075154 0,08770936 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02075154 0,08755787 ! thymic T cell selection GO:0045061 16 6 0,000 0,02075154 0,08740691 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02075154 0,08725647 ! protein lipoylation GO:0009249 10 6 0,000 0,02075154 0,08710654 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02075154 0,08695713 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02075154 0,08680823 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02075154 0,08665984 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02075154 0,08651196 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02075154 0,08636458 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02075154 0,0862177 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02075154 0,08607132 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02075154 0,08592544 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02075154 0,08578005 ! hyperosmotic response GO:0006972 10 6 0,000 0,02075154 0,08563515 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02075154 0,08549074 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02075154 0,08534681 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02075154 0,08520337 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02075154 0,08506042 ! urea metabolic process GO:0019627 7 6 0,000 0,02075154 0,08491794 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02075154 0,08477593 ! neutrophil activation GO:0042119 7 6 0,000 0,02075154 0,0846344 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02075154 0,08449335 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02075154 0,08435276 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02075154 0,08421264 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02075154 0,08407298 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02075154 0,08393379 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02075154 0,08379505 ! neuron apoptosis GO:0051402 15 6 0,000 0,02075154 0,08365678 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02075154 0,08351896 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02075154 0,08338159 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02075154 0,08324468 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02075154 0,08310821 ! carnitine transport GO:0015879 10 6 0,000 0,02075154 0,08297219 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02075154 0,08283661 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02075154 0,08270148 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02075154 0,08256679 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02075154 0,08243253 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02075154 0,08229871 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02075154 0,08216533 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02075154 0,08203238 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02075154 0,08189985 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02075154 0,08176775 ! establishment of spindle localization GO:0051293 16 6 0,000 0,02075154 0,08163608 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02075154 0,08150484 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02075154 0,08137401 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,02075154 0,0812436 ! astrocyte development GO:0014002 16 6 0,000 0,02075154 0,08111361 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02075154 0,08098404 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02075154 0,08085488 ! interaction with symbiont GO:0051702 14 6 0,000 0,02075154 0,08072613 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02075154 0,08059779 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02075154 0,08046985 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02075154 0,08034233 ! response to copper ion GO:0046688 10 6 0,000 0,02075154 0,0802152 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02075154 0,08008848 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02075154 0,07996216 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02075154 0,07983623 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02075154 0,0797107 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02075154 0,07958557 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02075154 0,07946083 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02075154 0,07933648 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02075154 0,07921251 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02075154 0,07908894 ! Schwann cell development GO:0014044 15 6 0,000 0,02075154 0,07896574 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02075154 0,07884294 ! response to pheromone GO:0019236 6 6 0,000 0,02075154 0,07872051 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02075154 0,07859846 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02075154 0,07847679 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02075154 0,0783555 ! subpallium development GO:0021544 15 6 0,000 0,02075154 0,07823458 ! neural tube patterning GO:0021532 8 6 0,000 0,02075154 0,07811403 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02075154 0,07799386 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02075154 0,07787405 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02075154 0,07775461 ! G2 phase GO:0051319 16 6 0,000 0,02075154 0,07763554 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02075154 0,07751683 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02075154 0,07739849 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02075154 0,0772805 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02075154 0,07716287 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02075154 0,0770456 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02075154 0,07692869 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02075154 0,07681213 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02075154 0,07669593 ! receptor internalization GO:0031623 11 6 0,000 0,02075154 0,07658007 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,02075154 0,07646457 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,02075154 0,07634941 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02075154 0,0762346 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02075154 0,07612013 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02075154 0,07600601 ! protein deubiquitination GO:0016579 16 6 0,000 0,02075154 0,07589223 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,02075154 0,07577879 ! protein destabilization GO:0031648 9 6 0,000 0,02075154 0,07566568 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02075154 0,07555292 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02075154 0,07544049 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02075154 0,07532839 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02075154 0,07521663 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02075154 0,0751052 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02075154 0,07499409 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02075154 0,07488332 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02075154 0,07477287 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02075154 0,07466275 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02075154 0,07455295 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02075154 0,07444348 ! neural plate development GO:0001840 9 6 0,000 0,02075154 0,07433432 ! catecholamine transport GO:0051937 9 6 0,000 0,02075154 0,07422549 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02075154 0,07411697 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02075154 0,07400877 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02075154 0,07390089 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02075154 0,07379332 ! maternal placenta development GO:0001893 12 6 0,000 0,02075154 0,07368606 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02075154 0,07357911 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02075154 0,07347248 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02075154 0,07336615 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02075154 0,07326013 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02075154 0,07315441 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02075154 0,073049 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02075154 0,0729439 GO:0055081|anion homeostasis, ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,02176255 0,07638781 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,02176255 0,07627822 GO:0048609|reproductive process in a multicellular organism, ! positive regulation of cell motion GO:0051272 157 65 1,000 0,02176255 0,07616894 ! ear development GO:0043583 114 66 1,000 0,02239215 0,07826041 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,02302924 0,08037204 ! fatty acid biosynthetic process GO:0006633 139 67 1,000 0,02302924 0,08025738 ! secondary metabolic process GO:0019748 125 67 1,000 0,02302924 0,08014306 ! hexose catabolic process GO:0019320 113 68 1,000 0,02367375 0,08226881 ! tRNA transcription GO:0009304 17 7 0,000 0,02416835 0,08386831 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02416835 0,08374935 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02416835 0,08363072 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02416835 0,08351243 ! regulation of helicase activity GO:0051095 16 7 0,000 0,02416835 0,08339448 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02416835 0,08327685 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02416835 0,08315956 ! sleep GO:0030431 16 7 0,000 0,02416835 0,0830426 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02416835 0,08292597 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02416835 0,08280966 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02416835 0,08269368 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02416835 0,08257803 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02416835 0,08246269 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02416835 0,08234768 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02416835 0,08223299 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02416835 0,08211862 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02416835 0,08200457 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02416835 0,08189083 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02416835 0,08177741 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02416835 0,0816643 ! glycolipid transport GO:0046836 11 7 0,000 0,02416835 0,0815515 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02416835 0,08143902 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,02416835 0,08132684 ! neuron adhesion GO:0007158 14 7 0,000 0,02416835 0,08121498 ! N-terminal protein amino acid acetylation GO:0006474 14 7 0,000 0,02416835 0,08110342 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02416835 0,08099217 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02416835 0,08088122 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02416835 0,08077057 ! mRNA stabilization GO:0048255 18 7 0,000 0,02416835 0,08066023 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,02416835 0,08055019 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,02416835 0,08044045 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,02416835 0,08033101 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,02416835 0,08022186 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02416835 0,08011301 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,02416835 0,08000446 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02416835 0,0798962 ! lipoprotein transport GO:0042953 14 7 0,000 0,02416835 0,07978823 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02416835 0,07968055 ! rhythmic behavior GO:0007622 17 7 0,000 0,02416835 0,07957317 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02416835 0,07946607 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02416835 0,07935926 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02416835 0,07925274 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02416835 0,0791465 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02416835 0,07904055 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02416835 0,07893488 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02416835 0,07882949 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02416835 0,07872439 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02416835 0,07861956 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02416835 0,07851501 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02416835 0,07841074 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02416835 0,07830675 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02416835 0,07820303 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02416835 0,07809959 ! spinal cord patterning GO:0021511 14 7 0,000 0,02416835 0,07799642 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02416835 0,07789352 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02416835 0,0777909 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02416835 0,07768854 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02416835 0,07758645 ! adrenal gland development GO:0030325 17 7 0,000 0,02416835 0,07748463 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02416835 0,07738308 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02416835 0,07728179 ! ovulation GO:0030728 10 7 0,000 0,02416835 0,07718077 ! adenohypophysis development GO:0021984 11 7 0,000 0,02416835 0,07708001 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02416835 0,07697952 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02416835 0,07687928 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02416835 0,07677931 ! microtubule nucleation GO:0007020 21 7 0,000 0,02416835 0,0766796 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02416835 0,07658014 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02416835 0,07648094 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02416835 0,076382 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02416835 0,07628332 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02416835 0,07618489 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02416835 0,07608671 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02416835 0,07598879 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02416835 0,07589112 ! galactose metabolic process GO:0006012 13 7 0,000 0,02416835 0,0757937 ! vesicle fusion GO:0006906 20 7 0,000 0,02416835 0,07569652 ! response to dietary excess GO:0002021 8 7 0,000 0,02416835 0,0755996 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02416835 0,07550293 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02416835 0,0754065 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02416835 0,07531032 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02416835 0,07521438 ! nucleoside transport GO:0015858 11 7 0,000 0,02416835 0,07511869 ! nucleoside salvage GO:0043174 11 7 0,000 0,02416835 0,07502324 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02416835 0,07492803 ! male sex determination GO:0030238 15 7 0,000 0,02416835 0,07483307 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02416835 0,07473834 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02416835 0,07464386 ! parturition GO:0007567 16 7 0,000 0,02416835 0,07454961 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02416835 0,0744556 ! rRNA modification GO:0000154 14 7 0,000 0,02416835 0,07436183 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02416835 0,07426829 ! spindle checkpoint GO:0031577 16 7 0,000 0,02416835 0,07417499 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02416835 0,07408192 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02416835 0,07398908 ! monocyte differentiation GO:0030224 16 7 0,000 0,02416835 0,07389648 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02416835 0,07380411 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,02416835 0,07371197 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,02416835 0,07362006 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02416835 0,07352838 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,02416835 0,07343693 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02416835 0,0733457 ! fibrinolysis GO:0042730 11 7 0,000 0,02416835 0,0732547 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02416835 0,07316393 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02416835 0,07307338 ! eating behavior GO:0042755 8 7 0,000 0,02416835 0,07298305 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02416835 0,07289295 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02416835 0,07280307 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02416835 0,07271341 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02416835 0,07262397 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,02416835 0,07253475 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02416835 0,07244575 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02416835 0,07235697 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02416835 0,07226841 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02416835 0,07218006 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02416835 0,07209193 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02416835 0,07200401 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02416835 0,07191631 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,02416835 0,07182882 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02416835 0,07174154 ! histone ubiquitination GO:0016574 9 7 0,000 0,02416835 0,07165448 ! regulation of meiosis GO:0040020 12 7 0,000 0,02416835 0,07156762 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02416835 0,07148098 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02416835 0,07139455 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02416835 0,07130832 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02416835 0,0712223 ! transcription termination GO:0006353 14 7 0,000 0,02416835 0,07113649 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02416835 0,07105089 ! anaphase GO:0051322 18 7 0,000 0,02416835 0,07096549 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02416835 0,0708803 ! axonal fasciculation GO:0007413 19 7 0,000 0,02416835 0,07079531 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02416835 0,07071053 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02416835 0,07062594 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02416835 0,07054156 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,02416835 0,07045739 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02416835 0,07037341 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02416835 0,07028963 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02416835 0,07020605 ! antibiotic transport GO:0042891 9 7 0,000 0,02416835 0,07012267 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02416835 0,07003949 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02416835 0,0699565 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02416835 0,06987372 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02416835 0,06979112 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02416835 0,06970872 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02416835 0,06962652 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02416835 0,06954451 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02416835 0,06946269 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02416835 0,06938107 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02416835 0,06929964 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02416835 0,06921839 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02416835 0,06913734 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02416835 0,06905648 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02416835 0,06897581 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02416835 0,06889532 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02416835 0,06881502 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02416835 0,06873491 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02416835 0,06865499 ! muscle adaptation GO:0043500 13 7 0,000 0,02416835 0,06857525 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02416835 0,0684957 ! retina homeostasis GO:0001895 12 7 0,000 0,02416835 0,06841633 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02416835 0,06833714 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02416835 0,06825814 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02416835 0,06817932 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02416835 0,06810068 ! negative regulation of cell size GO:0045792 144 69 1,000 0,02432564 0,06846489 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,02432564 0,06838611 ! developmental maturation GO:0021700 128 69 1,000 0,02432564 0,0683075 ! carbohydrate transport GO:0008643 114 72 1,000 0,02632493 0,07383674 ! B cell activation GO:0042113 179 72 1,000 0,02632493 0,07375206 ! humoral immune response GO:0006959 115 73 1,000 0,02700571 0,07557269 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02757334 0,07707286 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02757334 0,07698478 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 0,000 0,02757334 0,07689689 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02757334 0,07680921 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02757334 0,07672173 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02757334 0,07663445 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02757334 0,07654736 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02757334 0,07646048 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02757334 0,07637379 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02757334 0,07628729 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02757334 0,076201 ! meiotic prophase I GO:0007128 14 8 0,000 0,02757334 0,07611489 ! response to zinc ion GO:0010043 12 8 0,000 0,02757334 0,07602898 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,02757334 0,07594327 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02757334 0,07585775 ! oligopeptide transport GO:0006857 16 8 0,000 0,02757334 0,07577242 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02757334 0,07568728 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02757334 0,07560233 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02757334 0,07551758 ! signal peptide processing GO:0006465 12 8 0,000 0,02757334 0,07543301 ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02757334 0,07534863 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02757334 0,07526445 ! succinate metabolic process GO:0006105 17 8 0,000 0,02757334 0,07518045 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02757334 0,07509663 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02757334 0,07501301 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02757334 0,07492957 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02757334 0,07484631 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02757334 0,07476324 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,02757334 0,07468035 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02757334 0,07459765 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02757334 0,07451513 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02757334 0,0744328 ! reflex GO:0060004 17 8 0,000 0,02757334 0,07435064 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02757334 0,07426867 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02757334 0,07418687 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02757334 0,07410526 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02757334 0,07402382 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,02757334 0,07394257 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02757334 0,07386149 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02757334 0,07378059 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02757334 0,07369987 ! histidine catabolic process GO:0006548 10 8 0,000 0,02757334 0,07361932 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02757334 0,07353895 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02757334 0,07345876 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02757334 0,07337874 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,02757334 0,07329889 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02757334 0,07321922 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02757334 0,07313972 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02757334 0,07306039 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02757334 0,07298123 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,02757334 0,07290225 ! macrophage activation GO:0042116 13 8 0,000 0,02757334 0,07282344 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02757334 0,07274479 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02757334 0,07266632 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02757334 0,07258802 ! purine salvage GO:0043101 12 8 0,000 0,02757334 0,07250988 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02757334 0,07243191 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02757334 0,07235411 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02757334 0,07227648 ! osteoblast development GO:0002076 17 8 0,000 0,02757334 0,07219901 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02757334 0,07212171 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02757334 0,07204458 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02757334 0,07196761 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02757334 0,0718908 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02757334 0,07181416 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02757334 0,07173768 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02757334 0,07166136 ! intermediate filament organization GO:0045109 12 8 0,000 0,02757334 0,07158521 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02757334 0,07150921 ! cellular extravasation GO:0045123 13 8 0,000 0,02757334 0,07143338 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02757334 0,07135771 ! response to antibiotic GO:0046677 11 8 0,000 0,02757334 0,0712822 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02757334 0,07120685 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02757334 0,07113166 ! DNA topological change GO:0006265 12 8 0,000 0,02757334 0,07105662 ! response to tropane GO:0014073 15 8 0,000 0,02757334 0,07098175 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,02757334 0,07090703 ! melanosome transport GO:0032402 13 8 0,000 0,02757334 0,07083247 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 0,000 0,02757334 0,07075807 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02757334 0,07068382 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02757334 0,07060973 ! mast cell activation GO:0045576 14 8 0,000 0,02757334 0,07053579 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02757334 0,07046201 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,02757334 0,07038838 ! gas homeostasis GO:0033483 14 8 0,000 0,02757334 0,07031491 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02757334 0,07024158 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02757334 0,07016842 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02757334 0,0700954 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02757334 0,07002254 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02757334 0,06994982 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,02757334 0,06987726 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02757334 0,06980485 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02757334 0,06973259 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02757334 0,06966048 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02757334 0,06958851 ! response to tumor cell GO:0002347 16 8 0,000 0,02757334 0,0695167 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02757334 0,06944503 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,02757334 0,06937351 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02757334 0,06930214 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02757334 0,06923091 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02757334 0,06915984 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02757334 0,0690889 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02757334 0,06901811 ! hormone catabolic process GO:0042447 17 8 0,000 0,02757334 0,06894747 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02757334 0,06887697 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02757334 0,06880662 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02757334 0,06873641 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02757334 0,06866634 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02757334 0,06859642 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02757334 0,06852663 ! adult feeding behavior GO:0008343 10 8 0,000 0,02757334 0,06845699 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02757334 0,06838749 ! ATP catabolic process GO:0006200 11 8 0,000 0,02757334 0,06831813 ! blastocyst growth GO:0001832 19 8 0,000 0,02757334 0,06824892 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02757334 0,06817984 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02757334 0,0681109 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02757334 0,0680421 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02757334 0,06797344 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02757334 0,06790492 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02757334 0,06783654 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02757334 0,06776829 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02757334 0,06770018 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02757334 0,06763221 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02757334 0,06756437 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02757334 0,06749667 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02757334 0,06742911 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02757334 0,06736168 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02757334 0,06729439 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02757334 0,06722723 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02757334 0,0671602 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,02757334 0,06709331 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02757334 0,06702655 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02757334 0,06695992 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02757334 0,06689343 ! eye development GO:0001654 155 75 1,000 0,02838847 0,06880261 ! rhythmic process GO:0048511 142 75 1,000 0,02838847 0,06873442 ! regulation of blood pressure GO:0008217 134 76 1,000 0,02909033 0,07036402 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,02909033 0,07029443 ! monosaccharide catabolic process GO:0046365 125 77 1,000 0,0297991 0,07193596 ! axon extension GO:0048675 16 9 0,000 0,03096655 0,07468043 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,03096655 0,07460678 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03096655 0,07453328 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03096655 0,07445992 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03096655 0,0743867 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03096655 0,07431363 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03096655 0,0742407 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03096655 0,07416792 ! reproductive behavior GO:0019098 22 9 0,000 0,03096655 0,07409528 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03096655 0,07402278 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,03096655 0,07395042 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,03096655 0,0738782 ! UTP metabolic process GO:0046051 10 9 0,000 0,03096655 0,07380612 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,03096655 0,07373419 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,03096655 0,07366239 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03096655 0,07359074 ! artery development GO:0060840 25 9 0,000 0,03096655 0,07351922 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03096655 0,07344784 ! regulation of glycolysis GO:0006110 20 9 0,000 0,03096655 0,0733766 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03096655 0,0733055 ! equilibrioception GO:0050957 20 9 0,000 0,03096655 0,07323454 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,03096655 0,07316371 ! chemosensory behavior GO:0007635 21 9 0,000 0,03096655 0,07309302 ! microtubule bundle formation GO:0001578 22 9 0,000 0,03096655 0,07302247 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,03096655 0,07295205 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03096655 0,07288177 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03096655 0,07281162 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03096655 0,07274161 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03096655 0,07267174 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03096655 0,07260199 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03096655 0,07253239 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03096655 0,07246291 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03096655 0,07239357 ! protein targeting to ER GO:0045047 25 9 0,000 0,03096655 0,07232436 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03096655 0,07225528 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,03096655 0,07218633 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 0,000 0,03096655 0,07211752 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03096655 0,07204884 ! glycine catabolic process GO:0006546 15 9 0,000 0,03096655 0,07198028 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03096655 0,07191186 ! endosome organization GO:0007032 20 9 0,000 0,03096655 0,07184357 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03096655 0,07177541 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03096655 0,07170737 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03096655 0,07163947 ! mannose metabolic process GO:0006013 13 9 0,000 0,03096655 0,07157169 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03096655 0,07150404 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03096655 0,07143652 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,03096655 0,07136913 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03096655 0,07130186 ! receptor clustering GO:0043113 20 9 0,000 0,03096655 0,07123472 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03096655 0,07116771 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03096655 0,07110082 ! retinol metabolic process GO:0042572 20 9 0,000 0,03096655 0,07103406 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03096655 0,07096743 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03096655 0,07090092 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,03096655 0,07083453 ! macrophage differentiation GO:0030225 15 9 0,000 0,03096655 0,07076827 ! oligodendrocyte development GO:0014003 11 9 0,000 0,03096655 0,07070213 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,03096655 0,07063611 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03096655 0,07057022 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03096655 0,07050445 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03096655 0,07043881 ! response to amine stimulus GO:0014075 13 9 0,000 0,03096655 0,07037328 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03096655 0,07030788 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03096655 0,0702426 ! erythrocyte development GO:0048821 17 9 0,000 0,03096655 0,07017744 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03096655 0,0701124 ! renal water homeostasis GO:0003091 15 9 0,000 0,03096655 0,07004748 ! postreplication repair GO:0006301 25 9 0,000 0,03096655 0,06998268 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03096655 0,069918 ! icosanoid secretion GO:0032309 15 9 0,000 0,03096655 0,06985344 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03096655 0,069789 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03096655 0,06972468 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03096655 0,06966048 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03096655 0,06959639 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03096655 0,06953242 ! sterol catabolic process GO:0016127 14 9 0,000 0,03096655 0,06946857 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,03096655 0,06940484 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03096655 0,06934123 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03096655 0,06927773 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,03096655 0,06921434 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,03096655 0,06915108 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03096655 0,06908792 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,03096655 0,06902489 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03096655 0,06896197 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03096655 0,06889916 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03096655 0,06883647 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03096655 0,06877389 ! purine base metabolic process GO:0006144 25 9 0,000 0,03096655 0,06871142 ! pigment granule transport GO:0051904 17 9 0,000 0,03096655 0,06864907 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,03096655 0,06858683 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03096655 0,06852471 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03096655 0,06846269 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03096655 0,06840079 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03096655 0,068339 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03096655 0,06827733 ! mitochondrion localization GO:0051646 18 9 0,000 0,03096655 0,06821576 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,03123715 0,06874986 ! response to hypoxia GO:0001666 178 81 1,000 0,03270218 0,07190947 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 1,000 0,03270218 0,0718448 ! protein import into nucleus GO:0006606 174 82 1,000 0,03344467 0,07341 ! response to oxygen levels GO:0070482 183 83 1,000 0,03419375 0,07498683 ! nuclear import GO:0051170 177 83 1,000 0,03419375 0,07491958 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,03434801 0,07519013 ! regulation of developmental growth GO:0048638 16 10 0,000 0,03434801 0,07512281 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,03434801 0,07505562 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,03434801 0,07498855 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,03434801 0,07492159 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,03434801 0,07485476 ! associative learning GO:0008306 21 10 0,000 0,03434801 0,07478804 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,03434801 0,07472144 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,03434801 0,07465497 ! phosphate transport GO:0006817 24 10 0,000 0,03434801 0,07458861 ! cell volume homeostasis GO:0006884 17 10 0,000 0,03434801 0,07452236 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,03434801 0,07445624 ! CTP metabolic process GO:0046036 11 10 0,000 0,03434801 0,07439023 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,03434801 0,07432434 ! GTP metabolic process GO:0046039 11 10 0,000 0,03434801 0,07425857 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,03434801 0,07419291 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,03434801 0,07412737 ! social behavior GO:0035176 29 10 0,000 0,03434801 0,07406194 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,03434801 0,07399663 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,03434801 0,07393144 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,03434801 0,07386636 ! androgen metabolic process GO:0008209 17 10 0,000 0,03434801 0,07380139 ! phospholipid efflux GO:0033700 19 10 0,000 0,03434801 0,07373654 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,03434801 0,0736718 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,03434801 0,07360718 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,03434801 0,07354267 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,03434801 0,07347827 ! lung alveolus development GO:0048286 26 10 0,000 0,03434801 0,07341398 ! pathogenesis GO:0009405 17 10 0,000 0,03434801 0,07334981 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03434801 0,07328575 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,03434801 0,0732218 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,03434801 0,07315796 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,03434801 0,07309424 ! endoderm development GO:0007492 18 10 0,000 0,03434801 0,07303062 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,03434801 0,07296711 ! arginine catabolic process GO:0006527 17 10 0,000 0,03434801 0,07290372 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,03434801 0,07284044 ! proline metabolic process GO:0006560 13 10 0,000 0,03434801 0,07277726 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,03434801 0,0727142 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,03434801 0,07265124 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,03434801 0,07258839 ! V(D)J recombination GO:0033151 34 10 0,000 0,03434801 0,07252565 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,03434801 0,07246302 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,03434801 0,0724005 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,03434801 0,07233809 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,03434801 0,07227578 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,03434801 0,07221358 ! multicellular organism growth GO:0035264 19 10 0,000 0,03434801 0,07215149 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,03434801 0,0720895 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,03434801 0,07202762 ! ruffle organization GO:0031529 17 10 0,000 0,03434801 0,07196585 ! epithelial cell development GO:0002064 21 10 0,000 0,03434801 0,07190418 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,03434801 0,07184262 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,03434801 0,07178117 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,03434801 0,07171981 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,03434801 0,07165857 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,03434801 0,07159742 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,03434801 0,07153639 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,03434801 0,07147545 ! motor axon guidance GO:0008045 22 10 0,000 0,03434801 0,07141462 ! copper ion homeostasis GO:0055070 13 10 0,000 0,03434801 0,0713539 ! regulation of bone resorption GO:0045124 25 10 0,000 0,03434801 0,07129327 ! protein heterooligomerization GO:0051291 17 10 0,000 0,03434801 0,07123275 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,03434801 0,07117233 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,03434801 0,07111202 ! segment specification GO:0007379 15 10 0,000 0,03434801 0,07105181 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,03434801 0,07099169 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,03434801 0,07093168 ! blastoderm segmentation GO:0007350 19 10 0,000 0,03434801 0,07087178 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,03434801 0,07081197 ! response to dsRNA GO:0043331 23 10 0,000 0,03434801 0,07075226 ! DNA ligation GO:0006266 18 10 0,000 0,03434801 0,07069266 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,03434801 0,07063315 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,03434801 0,07057374 ! melanosome localization GO:0032400 16 10 0,000 0,03434801 0,07051444 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,03434801 0,07045523 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,03434801 0,07039613 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,03434801 0,07033712 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,03434801 0,07027821 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,03434801 0,0702194 ! induction of an organ GO:0001759 17 10 0,000 0,03434801 0,07016069 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,03434801 0,07010207 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,03434801 0,07004356 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,03434801 0,06998514 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,03434801 0,06992682 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03434801 0,06986859 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,03434801 0,06981047 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,03434801 0,06975244 ! salivary gland development GO:0007431 28 10 0,000 0,03434801 0,0696945 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,03434801 0,06963667 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,03434801 0,06957892 ! midbrain development GO:0030901 14 10 0,000 0,03434801 0,06952128 ! musculoskeletal movement GO:0050881 16 10 0,000 0,03434801 0,06946373 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,03434801 0,06940627 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,03434801 0,06934891 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,03434801 0,06929164 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,03434801 0,06923447 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,03434801 0,0691774 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,03434801 0,06912041 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,03434801 0,06906352 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,03434801 0,06900673 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,03434801 0,06895003 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,03434801 0,06889342 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,03434801 0,0688369 ! blastocyst formation GO:0001825 18 10 0,000 0,03434801 0,06878048 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,03434801 0,06872415 ! cerebellar cortex development GO:0021695 16 10 0,000 0,03434801 0,06866791 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,03434801 0,06861176 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,03434801 0,0685557 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,03434801 0,06849974 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,03434801 0,06844387 ! response to metal ion GO:0010038 158 84 1,000 0,03494935 0,06958538 ! T cell activation GO:0042110 189 84 1,000 0,03494935 0,06952872 ! response to nutrient GO:0007584 135 84 1,000 0,03494935 0,06947214 ! negative regulation of growth GO:0045926 168 85 1,000 0,03571143 0,07092928 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,03571143 0,07087166 ! cellular response to hormone stimulus GO:0032870 182 85 1,000 0,03571143 0,07081414 ! mitochondrion organization GO:0007005 159 87 1,000 0,03725478 0,07381462 ! alcohol catabolic process GO:0046164 142 87 1,000 0,03725478 0,07375481 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,03771776 0,07461092 ! respiratory burst GO:0045730 17 11 0,000 0,03771776 0,07455056 ! neuron fate specification GO:0048665 18 11 0,000 0,03771776 0,07449029 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03771776 0,07443012 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03771776 0,07437005 ! thyroid gland development GO:0030878 26 11 0,000 0,03771776 0,07431007 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 0,000 0,03771776 0,07425019 ! synapsis GO:0007129 14 11 0,000 0,03771776 0,07419041 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03771776 0,07413073 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03771776 0,07407113 ! response to pain GO:0048265 27 11 0,000 0,03771776 0,07401164 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,03771776 0,07395224 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03771776 0,07389294 ! blood vessel remodeling GO:0001974 30 11 0,000 0,03771776 0,07383373 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,03771776 0,07377461 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,03771776 0,07371559 ! bone resorption GO:0045453 16 11 0,000 0,03771776 0,07365667 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03771776 0,07359784 ! peptide or protein amino-terminal blocking GO:0018409 22 11 0,000 0,03771776 0,0735391 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03771776 0,07348046 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03771776 0,07342191 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03771776 0,07336345 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03771776 0,07330508 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03771776 0,07324681 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03771776 0,07318864 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03771776 0,07313055 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,03771776 0,07307255 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03771776 0,07301465 ! UV protection GO:0009650 20 11 0,000 0,03771776 0,07295684 ! adult heart development GO:0007512 16 11 0,000 0,03771776 0,07289912 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03771776 0,0728415 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03771776 0,07278396 ! macroautophagy GO:0016236 19 11 0,000 0,03771776 0,07272651 ! temperature homeostasis GO:0001659 18 11 0,000 0,03771776 0,07266916 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03771776 0,07261189 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,03771776 0,07255472 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03771776 0,07249763 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03771776 0,07244064 ! regulation of organ growth GO:0046620 14 11 0,000 0,03771776 0,07238373 ! pigment granule localization GO:0051875 20 11 0,000 0,03771776 0,07232692 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03771776 0,07227019 ! vasoconstriction GO:0042310 20 11 0,000 0,03771776 0,07221355 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03771776 0,072157 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03771776 0,07210054 ! embryonic axis specification GO:0000578 19 11 0,000 0,03771776 0,07204417 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03771776 0,07198788 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03771776 0,07193169 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03771776 0,07187558 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03771776 0,07181956 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03771776 0,07176362 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03771776 0,07170778 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03771776 0,07165202 ! prophase GO:0051324 17 11 0,000 0,03771776 0,07159634 ! neuroblast proliferation GO:0007405 25 11 0,000 0,03771776 0,07154075 ! nucleosome positioning GO:0016584 15 11 0,000 0,03771776 0,07148525 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03771776 0,07142984 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03771776 0,07137451 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03771776 0,07131927 ! apical protein localization GO:0045176 18 11 0,000 0,03771776 0,07126411 ! acid secretion GO:0046717 20 11 0,000 0,03771776 0,07120904 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03771776 0,07115405 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03771776 0,07109914 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,03771776 0,07104433 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03771776 0,07098959 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03771776 0,07093494 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03771776 0,07088038 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,03771776 0,0708259 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03771776 0,0707715 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03771776 0,07071718 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03771776 0,07066295 ! embryonic gut development GO:0048566 19 11 0,000 0,03771776 0,07060881 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03771776 0,07055474 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03771776 0,07050076 ! activation of innate immune response GO:0002218 16 11 0,000 0,03771776 0,07044686 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03771776 0,07039304 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03771776 0,07033931 ! lysogeny GO:0030069 22 11 0,000 0,03771776 0,07028565 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03771776 0,07023208 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03771776 0,07017859 ! regulation of embryonic development GO:0045995 35 11 0,000 0,03771776 0,07012518 ! nucleus localization GO:0051647 22 11 0,000 0,03771776 0,07007186 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,03803595 0,0706093 ! tube morphogenesis GO:0035239 194 89 1,000 0,03882339 0,07201635 ! protein localization in nucleus GO:0034504 192 89 1,000 0,03882339 0,07196171 ! regulation of neurological system process GO:0031644 175 89 1,000 0,03882339 0,07190715 ! response to inorganic substance GO:0010035 173 90 1,000 0,03961703 0,07332152 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,04107585 0,07596389 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,04107585 0,07590643 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,04107585 0,07584906 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,04107585 0,07579177 ! virus-host interaction GO:0019048 30 12 0,000 0,04107585 0,07573457 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,04107585 0,07567745 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,04107585 0,07562043 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,04107585 0,07556348 ! protein complex disassembly GO:0043241 28 12 0,000 0,04107585 0,07550662 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,04107585 0,07544985 ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,04107585 0,07539317 ! hippocampus development GO:0021766 29 12 0,000 0,04107585 0,07533656 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,04107585 0,07528005 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,04107585 0,07522362 ! T cell proliferation GO:0042098 32 12 0,000 0,04107585 0,07516727 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,04107585 0,07511101 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,04107585 0,07505483 ! ventral spinal cord development GO:0021517 25 12 0,000 0,04107585 0,07499873 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,04107585 0,07494272 ! drug transport GO:0015893 16 12 0,000 0,04107585 0,07488679 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,04107585 0,07483095 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,04107585 0,07477519 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,04107585 0,07471951 ! polyamine metabolic process GO:0006595 18 12 0,000 0,04107585 0,07466392 ! mitotic spindle organization GO:0007052 23 12 0,000 0,04107585 0,0746084 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,04107585 0,07455298 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,04107585 0,07449763 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,04107585 0,07444236 ! lipid digestion GO:0044241 21 12 0,000 0,04107585 0,07438718 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,04107585 0,07433208 ! entry into host cell GO:0030260 34 12 0,000 0,04107585 0,07427706 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04107585 0,07422212 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,04107585 0,07416726 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,04107585 0,07411248 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,04107585 0,07405779 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,04107585 0,07400317 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,04107585 0,07394864 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,04107585 0,07389419 ! snRNA metabolic process GO:0016073 30 12 0,000 0,04107585 0,07383981 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,04107585 0,07378552 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,04107585 0,0737313 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,04107585 0,07367717 ! cranial nerve development GO:0021545 23 12 0,000 0,04107585 0,07362311 ! fucose catabolic process GO:0019317 25 12 0,000 0,04107585 0,07356914 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,04107585 0,07351524 ! histone acetylation GO:0016573 27 12 0,000 0,04107585 0,07346142 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,04107585 0,07340768 ! autonomic nervous system development GO:0048483 24 12 0,000 0,04107585 0,07335402 ! zymogen activation GO:0031638 18 12 0,000 0,04107585 0,07330044 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,04107585 0,07324694 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,04107585 0,07319351 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,04107585 0,07314016 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,04107585 0,07308689 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,04107585 0,0730337 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,04107585 0,07298059 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,04107585 0,07292755 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,04107585 0,07287459 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,04107585 0,0728217 ! defense response to fungus GO:0050832 15 12 0,000 0,04107585 0,07276889 ! developmental induction GO:0031128 22 12 0,000 0,04107585 0,07271616 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,04107585 0,07266351 ! lamellipodium assembly GO:0030032 24 12 0,000 0,04107585 0,07261093 ! response to cold GO:0009409 17 12 0,000 0,04107585 0,07255843 ! establishment of cell polarity GO:0030010 21 12 0,000 0,04107585 0,072506 ! regulation of synapse organization GO:0050807 18 12 0,000 0,04107585 0,07245365 ! localization within membrane GO:0051668 26 12 0,000 0,04107585 0,07240137 ! female pregnancy GO:0007565 166 94 1,000 0,04285263 0,07547872 ! regulation of defense response GO:0031347 171 95 1,000 0,04367654 0,07687448 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,04367654 0,07681913 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,04442232 0,07807462 ! cGMP metabolic process GO:0046068 18 13 0,000 0,04442232 0,07801849 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,04442232 0,07796244 ! regulation of chemokine production GO:0032642 18 13 0,000 0,04442232 0,07790647 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,04442232 0,07785059 ! peroxisomal transport GO:0043574 28 13 0,000 0,04442232 0,07779478 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,04442232 0,07773905 ! cartilage condensation GO:0001502 22 13 0,000 0,04442232 0,07768341 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,04442232 0,07762784 ! organelle fusion GO:0048284 36 13 0,000 0,04442232 0,07757235 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,04442232 0,07751694 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,04442232 0,07746161 ! endocrine pancreas development GO:0031018 25 13 0,000 0,04442232 0,07740636 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,04442232 0,07735119 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,04442232 0,0772961 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,04442232 0,07724108 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,04442232 0,07718614 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,04442232 0,07713129 ! methionine metabolic process GO:0006555 31 13 0,000 0,04442232 0,0770765 ! plasma membrane organization GO:0007009 27 13 0,000 0,04442232 0,0770218 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,04442232 0,07696718 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,04442232 0,07691263 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,04442232 0,07685816 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,04442232 0,07680376 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,04442232 0,07674945 ! cytokine metabolic process GO:0042107 24 13 0,000 0,04442232 0,07669521 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,04442232 0,07664104 ! exocrine system development GO:0035272 34 13 0,000 0,04442232 0,07658696 ! asymmetric protein localization GO:0008105 24 13 0,000 0,04442232 0,07653295 ! monoamine transport GO:0015844 21 13 0,000 0,04442232 0,07647901 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,04442232 0,07642515 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,04442232 0,07637137 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,04442232 0,07631766 ! protein homotetramerization GO:0051289 24 13 0,000 0,04442232 0,07626403 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,04442232 0,07621048 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,04442232 0,076157 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,04442232 0,07610359 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,04442232 0,07605026 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,04442232 0,075997 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,04442232 0,07594382 ! regulation of monooxygenase activity GO:0032768 35 13 0,000 0,04442232 0,07589071 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,04442232 0,07583768 ! histone methylation GO:0016571 29 13 0,000 0,04442232 0,07578472 ! chromatin silencing GO:0006342 29 13 0,000 0,04442232 0,07573183 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,04442232 0,07567902 ! regulation of epidermis development GO:0045682 19 13 0,000 0,04442232 0,07562628 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,04442232 0,07557362 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,04442232 0,07552103 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,04442232 0,07546851 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,04442232 0,07541607 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,04442232 0,07536369 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,04442232 0,07531139 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,04442232 0,07525917 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,04442232 0,07520701 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,04442232 0,07515493 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,04442232 0,07510292 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,04442232 0,07505098 ! insulin secretion GO:0030073 24 13 0,000 0,04442232 0,07499911 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,04442232 0,07494732 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,04442232 0,0748956 ! acrosome reaction GO:0007340 19 13 0,000 0,04442232 0,07484394 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,04442232 0,07479236 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,04442232 0,07474085 ! response to protein stimulus GO:0051789 158 96 1,000 0,04450634 0,07483069 ! transcription initiation GO:0006352 171 97 1,000 0,04534199 0,07618328 ! leukocyte differentiation GO:0002521 232 98 1,000 0,04618344 0,07754374 ! rRNA transcription GO:0009303 28 14 0,000 0,0477572 0,08013107 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,0477572 0,08007607 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,0477572 0,08002115 ! water transport GO:0006833 21 14 0,000 0,0477572 0,0799663 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,0477572 0,07991153 ! non-recombinational repair GO:0000726 29 14 0,000 0,0477572 0,07985683 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,0477572 0,07980221 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,0477572 0,07974766 ! RNA polyadenylation GO:0043631 32 14 0,000 0,0477572 0,07969319 ! lipid localization GO:0010876 32 14 0,000 0,0477572 0,07963879 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,0477572 0,07958447 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,0477572 0,07953022 ! regulated secretory pathway GO:0045055 24 14 0,000 0,0477572 0,07947604 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,0477572 0,07942194 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,0477572 0,07936791 ! arginine metabolic process GO:0006525 21 14 0,000 0,0477572 0,07931396 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,0477572 0,07926008 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,0477572 0,07920627 ! regulation of heart rate GO:0002027 25 14 0,000 0,0477572 0,07915253 ! organic alcohol transport GO:0015850 29 14 0,000 0,0477572 0,07909887 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,0477572 0,07904528 ! embryo implantation GO:0007566 30 14 0,000 0,0477572 0,07899176 ! neutral amino acid transport GO:0015804 28 14 0,000 0,0477572 0,07893832 ! bone mineralization GO:0030282 18 14 0,000 0,0477572 0,07888494 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,0477572 0,07883164 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,0477572 0,07877841 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,0477572 0,07872526 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,0477572 0,07867217 ! regulation of cellular pH GO:0030641 27 14 0,000 0,0477572 0,07861916 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,0477572 0,07856622 ! ribosome assembly GO:0042255 18 14 0,000 0,0477572 0,07851335 ! cerebellum development GO:0021549 23 14 0,000 0,0477572 0,07846055 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,0477572 0,07840782 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,0477572 0,07835516 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,0477572 0,07830257 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,0477572 0,07825005 ! NADP metabolic process GO:0006739 24 14 0,000 0,0477572 0,07819761 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,0477572 0,07814523 ! oxygen transport GO:0015671 22 14 0,000 0,0477572 0,07809293 ! male genitalia development GO:0030539 26 14 0,000 0,0477572 0,07804069 ! regulation of RNA stability GO:0043487 33 14 0,000 0,0477572 0,07798852 ! regulation of axon extension GO:0030516 43 14 0,000 0,0477572 0,07793643 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,0477572 0,0778844 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,0477572 0,07783244 ! lactation GO:0007595 30 15 0,000 0,05108053 0,08319316 ! N-terminal protein amino acid modification GO:0031365 30 15 0,000 0,05108053 0,08313773 ! reproductive cellular process GO:0048610 22 15 0,000 0,05108053 0,08308238 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,05108053 0,08302711 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,05108053 0,0829719 ! superoxide anion generation GO:0042554 22 15 0,000 0,05108053 0,08291677 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,05108053 0,08286171 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,05108053 0,08280673 ! copper ion transport GO:0006825 22 15 0,000 0,05108053 0,08275182 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,05108053 0,08269698 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,05108053 0,08264221 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,05108053 0,08258752 ! sulfate transport GO:0008272 27 15 0,000 0,05108053 0,0825329 ! response to cAMP GO:0051591 25 15 0,000 0,05108053 0,08247835 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,05108053 0,08242387 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,05108053 0,08236947 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,05108053 0,08231513 ! response to hexose stimulus GO:0009746 25 15 0,000 0,05108053 0,08226087 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,05108053 0,08220668 ! vesicle coating GO:0006901 38 15 0,000 0,05108053 0,08215256 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,05108053 0,08209851 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,05108053 0,08204454 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,05108053 0,08199063 ! regulation of exocytosis GO:0017157 26 15 0,000 0,05108053 0,0819368 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,05108053 0,08188303 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,05108053 0,08182934 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,05108053 0,08177571 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,05108053 0,08172216 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,05108053 0,08166868 ! regulation of vasodilation GO:0042312 27 15 0,000 0,05108053 0,08161526 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,05108053 0,08156192 ! histone deacetylation GO:0016575 24 15 0,000 0,05108053 0,08150865 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,05108053 0,08145544 ! water homeostasis GO:0030104 28 15 0,000 0,05108053 0,08140231 ! cofactor transport GO:0051181 30 15 0,000 0,05108053 0,08134924 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,05108053 0,08129625 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,05108053 0,08124332 ! intestinal absorption GO:0050892 31 15 0,000 0,05108053 0,08119046 ! dopamine metabolic process GO:0042417 35 15 0,000 0,05108053 0,08113767 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,05108053 0,08108495 ! heme biosynthetic process GO:0006783 33 15 0,000 0,05108053 0,0810323 ! cell killing GO:0001906 32 15 0,000 0,05108053 0,08097971 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,05108053 0,0809272 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,05108053 0,08087475 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,05108053 0,08082237 ! actin filament polymerization GO:0030041 27 15 0,000 0,05108053 0,08077006 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,05108053 0,08071781 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,05439236 0,08589563 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,05439236 0,08584014 ! positive regulation of cell size GO:0045793 29 16 0,000 0,05439236 0,08578473 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,05439236 0,08572938 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,05439236 0,08567411 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,05439236 0,08561891 ! bone remodeling GO:0046849 28 16 0,000 0,05439236 0,08556377 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,05439236 0,08550871 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,05439236 0,08545372 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05439236 0,08539881 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,05439236 0,08534396 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,05439236 0,08528918 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,05439236 0,08523447 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,05439236 0,08517983 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,05439236 0,08512527 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,05439236 0,08507077 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,05439236 0,08501634 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,05439236 0,08496198 ! protein polyubiquitination GO:0000209 41 16 0,000 0,05439236 0,08490769 ! glutamate metabolic process GO:0006536 25 16 0,000 0,05439236 0,08485347 ! pituitary gland development GO:0021983 30 16 0,000 0,05439236 0,08479932 ! response to osmotic stress GO:0006970 27 16 0,000 0,05439236 0,08474524 ! lysosomal transport GO:0007041 31 16 0,000 0,05439236 0,08469123 ! L-amino acid transport GO:0015807 33 16 0,000 0,05439236 0,08463729 ! stem cell development GO:0048864 46 16 0,000 0,05439236 0,08458341 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,05439236 0,08452961 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,05439236 0,08447587 ! intermediate filament-based process GO:0045103 36 16 0,000 0,05439236 0,0844222 ! negative regulation of immune response GO:0050777 38 16 0,000 0,05439236 0,0843686 ! axon cargo transport GO:0008088 46 16 0,000 0,05439236 0,08431506 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,05439236 0,0842616 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,05439236 0,0842082 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,05439236 0,08415487 ! neuron recognition GO:0008038 40 16 0,000 0,05439236 0,08410161 ! mRNA splice site selection GO:0006376 44 16 0,000 0,05439236 0,08404841 ! tissue regeneration GO:0042246 27 16 0,000 0,05439236 0,08399528 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,05439236 0,08394222 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,05439236 0,08388923 ! biomineral formation GO:0031214 22 16 0,000 0,05439236 0,0838363 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,05439236 0,08378344 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,05439236 0,08373065 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,05439236 0,08367792 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,05439236 0,08362526 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,05439236 0,08357267 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,05439236 0,08352014 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,05439236 0,08346768 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,05439236 0,08341528 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,05439236 0,08336295 ! peptide hormone processing GO:0016486 27 16 0,000 0,05439236 0,08331068 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,05769273 0,08831036 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,05769273 0,08825506 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,05769273 0,08819983 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,05769273 0,08814467 ! signal complex assembly GO:0007172 47 17 0,000 0,05769273 0,08808958 ! filopodium assembly GO:0046847 42 17 0,000 0,05769273 0,08803456 ! endothelial cell migration GO:0043542 31 17 0,000 0,05769273 0,08797961 ! gene silencing by RNA GO:0031047 38 17 0,000 0,05769273 0,08792472 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,05769273 0,08786991 ! glial cell development GO:0021782 28 17 0,000 0,05769273 0,08781516 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,05769273 0,08776048 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,05769273 0,08770587 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,05769273 0,08765133 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,05769273 0,08759685 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,05769273 0,08754244 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,05769273 0,0874881 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,05769273 0,08743383 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,05769273 0,08737962 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,05769273 0,08732548 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,05769273 0,08727141 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,05769273 0,08721741 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,05769273 0,08716347 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,05769273 0,0871096 ! membrane budding GO:0006900 42 17 0,000 0,05769273 0,08705579 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,05769273 0,08700206 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,05769273 0,08694838 ! genitalia development GO:0048806 32 17 0,000 0,05769273 0,08689478 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,05769273 0,08684124 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,05769273 0,08678777 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,05769273 0,08673436 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,05769273 0,08668102 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,05769273 0,08662774 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,05769273 0,08657453 ! steroid catabolic process GO:0006706 34 17 0,000 0,05769273 0,08652138 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,05769273 0,0864683 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,05769273 0,08641529 ! gas transport GO:0015669 26 17 0,000 0,05769273 0,08636234 ! organic cation transport GO:0015695 32 17 0,000 0,05769273 0,08630945 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,05769273 0,08625663 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,05769273 0,08620387 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,06098166 0,09106247 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,06098166 0,09100685 ! limbic system development GO:0021761 40 18 0,000 0,06098166 0,09095129 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,06098166 0,09089579 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,06098166 0,09084037 ! adult walking behavior GO:0007628 36 18 0,000 0,06098166 0,09078501 ! patterning of blood vessels GO:0001569 43 18 0,000 0,06098166 0,09072972 ! heart looping GO:0001947 34 18 0,000 0,06098166 0,0906745 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,06098166 0,09061935 ! centrosome cycle GO:0007098 26 18 0,000 0,06098166 0,09056426 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,06098166 0,09050924 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,06098166 0,09045428 ! glycine metabolic process GO:0006544 30 18 0,000 0,06098166 0,0903994 ! glutamine metabolic process GO:0006541 29 18 0,000 0,06098166 0,09034458 ! response to retinoic acid GO:0032526 31 18 0,000 0,06098166 0,09028982 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 0,000 0,06098166 0,09023513 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,06098166 0,09018051 ! DNA integration GO:0015074 32 18 0,000 0,06098166 0,09012596 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,06098166 0,09007147 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,06098166 0,09001704 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,06098166 0,08996269 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,06098166 0,08990839 ! neural crest cell migration GO:0001755 41 18 0,000 0,06098166 0,08985417 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,06098166 0,0898 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,06098166 0,08974591 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,06098166 0,08969188 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,06098166 0,08963791 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,06098166 0,08958401 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,06098166 0,08953017 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,06098166 0,0894764 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,06098166 0,08942269 ! detection of bacterium GO:0016045 22 18 0,000 0,06098166 0,08936905 ! nerve development GO:0021675 34 18 0,000 0,06098166 0,08931547 ! microspike assembly GO:0030035 46 18 0,000 0,06098166 0,08926196 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,06098166 0,08920851 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,06098166 0,08915512 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,06425922 0,09389071 ! positive regulation of translation GO:0045727 31 19 0,000 0,06425922 0,09383459 ! negative regulation of defense response GO:0031348 27 19 0,000 0,06425922 0,09377853 ! neuron maturation GO:0042551 46 19 0,000 0,06425922 0,09372255 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,06425922 0,09366663 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,06425922 0,09361077 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,06425922 0,09355498 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,06425922 0,09349926 ! inositol metabolic process GO:0006020 33 19 0,000 0,06425922 0,09344361 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,06425922 0,09338802 ! memory GO:0007613 34 19 0,000 0,06425922 0,0933325 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,06425922 0,09327704 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,06425922 0,09322165 GO:0042744|hydrogen peroxide catabolic process, ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,06425922 0,09316633 ! cerebral cortex development GO:0021987 40 19 0,000 0,06425922 0,09311107 ! pigmentation during development GO:0048066 42 19 0,000 0,06425922 0,09305588 ! response to vitamin A GO:0033189 32 19 0,000 0,06425922 0,09300075 ! heme metabolic process GO:0042168 40 19 0,000 0,06425922 0,09294569 ! neuromuscular junction development GO:0007528 43 19 0,000 0,06425922 0,09289069 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,06425922 0,09283576 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,06425922 0,09278089 ! response to fungus GO:0009620 26 19 0,000 0,06425922 0,09272609 ! peptide cross-linking GO:0018149 39 19 0,000 0,06425922 0,09267135 ! protein export from nucleus GO:0006611 40 19 0,000 0,06425922 0,09261667 ! heart process GO:0003015 32 19 0,000 0,06425922 0,09256207 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,06425922 0,09250752 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,06425922 0,09245304 ! visual learning GO:0008542 38 19 0,000 0,06425922 0,09239862 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,06425922 0,09234427 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,06425922 0,09228998 ! vitamin transport GO:0051180 31 19 0,000 0,06425922 0,09223576 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,06425922 0,0921816 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,06425922 0,0921275 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,06425922 0,09207347 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,06425922 0,0920195 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,06425922 0,09196559 ! cilium assembly GO:0042384 38 19 0,000 0,06425922 0,09191175 ! peptide hormone secretion GO:0030072 32 19 0,000 0,06425922 0,09185797 ! protein secretion GO:0009306 45 20 0,000 0,06752542 0,09647052 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,06752542 0,09641414 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,06752542 0,09635783 ! positive regulation of ossification GO:0045778 50 20 0,000 0,06752542 0,09630157 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,06752542 0,09624539 ! skin development GO:0043588 42 20 0,000 0,06752542 0,09618927 ! phosphoinositide phosphorylation GO:0046854 40 20 0,000 0,06752542 0,09613322 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,06752542 0,09607723 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,06752542 0,0960213 ! protein amino acid acetylation GO:0006473 41 20 0,000 0,06752542 0,09596544 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,06752542 0,09590965 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,06752542 0,09585392 ! response to vitamin GO:0033273 36 20 0,000 0,06752542 0,09579826 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,06752542 0,09574266 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,06752542 0,09568712 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,06752542 0,09563165 ! bile acid metabolic process GO:0008206 34 20 0,000 0,06752542 0,09557624 ! retinoid metabolic process GO:0001523 34 20 0,000 0,06752542 0,0955209 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,06752542 0,09546562 ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,06752542 0,09541041 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,06752542 0,09535526 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,06752542 0,09530017 ! peptide secretion GO:0002790 38 20 0,000 0,06752542 0,09524515 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,06752542 0,09519019 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,06752542 0,09513529 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,06752542 0,09508046 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,06752542 0,09502569 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,06752542 0,09497098 ! cell-cell junction organization GO:0045216 43 20 0,000 0,06752542 0,09491634 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,06752542 0,09486176 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,06752542 0,09480724 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,06752542 0,09475278 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,06752542 0,09469839 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,06752542 0,09464406 ! regulation of glucose import GO:0046324 30 20 0,000 0,06752542 0,09458979 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,06752542 0,09453559 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,06752542 0,09448144 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,06752542 0,09442736 ! negative regulation of translation GO:0017148 32 20 0,000 0,06752542 0,09437334 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,06752542 0,09431938 ! regulation of cell killing GO:0031341 46 21 0,000 0,07078031 0,09880932 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,07078031 0,09875289 ! hormone secretion GO:0046879 39 21 0,000 0,07078031 0,09869652 ! lipid phosphorylation GO:0046834 43 21 0,000 0,07078031 0,09864022 ! cAMP metabolic process GO:0046058 41 21 0,000 0,07078031 0,09858398 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,07078031 0,09852781 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,07078031 0,0984717 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,07078031 0,09841565 ! smooth muscle contraction GO:0006939 48 21 0,000 0,07078031 0,09835967 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 0,000 0,07078031 0,09830375 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,07078031 0,0982479 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,07078031 0,09819211 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,07078031 0,09813638 ! plasma membrane fusion GO:0045026 33 21 0,000 0,07078031 0,09808072 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,07078031 0,09802511 ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,07078031 0,09796958 ! sensory perception of pain GO:0019233 33 21 0,000 0,07078031 0,0979141 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,07078031 0,09785869 ! diencephalon development GO:0021536 36 21 0,000 0,07078031 0,09780334 ! collagen fibril organization GO:0030199 62 21 0,000 0,07078031 0,09774805 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,07078031 0,09769283 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,07078031 0,09763766 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,07078031 0,09758256 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,07078031 0,09752753 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,07078031 0,09747255 ! collagen catabolic process GO:0030574 29 21 0,000 0,07078031 0,09741764 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,07078031 0,09736278 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,07078031 0,09730799 ! sperm-egg recognition GO:0035036 23 21 0,000 0,07078031 0,09725326 ! actin filament-based movement GO:0030048 47 21 0,000 0,07078031 0,0971986 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,07078031 0,09714399 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,07402394 0,10153873 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,07402394 0,10148175 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,07402394 0,10142483 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,07402394 0,10136798 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,07402394 0,10131119 ! microtubule-based transport GO:0010970 59 22 0,000 0,07402394 0,10125447 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,07402394 0,1011978 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,07402394 0,10114121 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,07402394 0,10108467 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,07402394 0,1010282 ! cellular response to starvation GO:0009267 37 22 0,000 0,07402394 0,10097179 ! vacuolar transport GO:0007034 41 22 0,000 0,07402394 0,10091544 ! central nervous system neuron development GO:0021954 47 22 0,000 0,07402394 0,10085916 ! fucose metabolic process GO:0006004 44 22 0,000 0,07402394 0,10080294 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,07402394 0,10074678 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,07402394 0,10069069 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,07402394 0,10063466 ! stem cell differentiation GO:0048863 57 22 0,000 0,07402394 0,10057868 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,07402394 0,10052278 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,07402394 0,10046693 ! cytolysis GO:0019835 27 22 0,000 0,07402394 0,10041115 ! vasodilation GO:0042311 40 22 0,000 0,07402394 0,10035542 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,07402394 0,10029976 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,07402394 0,10024417 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,07402394 0,10018863 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,07402394 0,10013315 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,07402394 0,10007774 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,07402394 0,10002239 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,07402394 0,0999671 ! sarcomere organization GO:0045214 32 22 0,000 0,07402394 0,09991186 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,07402394 0,0998567 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,07402394 0,09980159 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,07402394 0,09974654 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,07402394 0,09969155 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,07402394 0,09963663 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,07402394 0,09958176 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,07402394 0,09952695 ! protein stabilization GO:0050821 41 22 0,000 0,07402394 0,09947221 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,07725633 0,10375877 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,07725633 0,10370176 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,07725633 0,10364482 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,07725633 0,10358793 ! gluconeogenesis GO:0006094 38 23 0,000 0,07725633 0,10353111 ! glycerol metabolic process GO:0006071 40 23 0,000 0,07725633 0,10347435 ! viral genome replication GO:0019079 44 23 0,000 0,07725633 0,10341765 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,07725633 0,10336101 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,07725633 0,10330444 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,07725633 0,10324793 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,07725633 0,10319148 ! axis specification GO:0009798 43 23 0,000 0,07725633 0,10313509 ! visual behavior GO:0007632 46 23 0,000 0,07725633 0,10307876 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,07725633 0,10302249 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,07725633 0,10296629 ! peroxisome organization GO:0007031 43 23 0,000 0,07725633 0,10291015 ! lysosome organization GO:0007040 47 23 0,000 0,07725633 0,10285406 ! vesicle targeting GO:0006903 49 23 0,000 0,07725633 0,10279804 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,07725633 0,10274208 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,07725633 0,10268619 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,07725633 0,10263035 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,07725633 0,10257457 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,07725633 0,10251885 ! fatty acid transport GO:0015908 47 23 0,000 0,07725633 0,1024632 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,07725633 0,1024076 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,07725633 0,10235207 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,07725633 0,10229659 ! hormone transport GO:0009914 41 23 0,000 0,07725633 0,10224118 ! cell-cell recognition GO:0009988 28 23 0,000 0,07725633 0,10218582 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,07725633 0,10213052 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,07725633 0,10207529 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,07725633 0,10202011 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,08047753 0,10621642 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,08047753 0,10615907 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,08047753 0,10610178 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,08047753 0,10604455 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,08047753 0,10598738 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,08047753 0,10593028 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,08047753 0,10587324 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,08047753 0,10581625 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,08047753 0,10575933 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,08047753 0,10570247 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 0,000 0,08047753 0,10564567 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,08047753 0,10558894 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,08047753 0,10553226 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,08047753 0,10547564 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,08047753 0,10541909 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,08047753 0,10536259 GO:0051693|actin filament capping, ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,08047753 0,10530616 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 52 24 0,000 0,08047753 0,10524979 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,08047753 0,10519347 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,08047753 0,10513722 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,08047753 0,10508103 ! membrane depolarization GO:0051899 45 24 0,000 0,08047753 0,10502489 ! pallium development GO:0021543 56 24 0,000 0,08047753 0,10496882 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,08047753 0,10491281 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,08047753 0,10485685 ! regulation of oxidoreductase activity GO:0051341 48 24 0,000 0,08047753 0,10480096 ! platelet activation GO:0030168 41 24 0,000 0,08047753 0,10474512 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,08047753 0,10468935 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,08047753 0,10463363 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,08047753 0,10457798 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,08047753 0,10452238 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,08047753 0,10446684 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,08047753 0,10441136 ! regulation of amine transport GO:0051952 41 24 0,000 0,08047753 0,10435594 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,08047753 0,10430058 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,08368757 0,10840336 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,08368757 0,10834591 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,08368757 0,10828853 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,08368757 0,1082312 ! leukocyte adhesion GO:0007159 55 25 0,000 0,08368757 0,10817394 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,08368757 0,10811673 ! phototransduction GO:0007602 37 25 0,000 0,08368757 0,10805959 ! keratinization GO:0031424 37 25 0,000 0,08368757 0,1080025 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,08368757 0,10794548 ! vacuole organization GO:0007033 49 25 0,000 0,08368757 0,10788852 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,08368757 0,10783161 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,08368757 0,10777477 ! receptor metabolic process GO:0043112 53 25 0,000 0,08368757 0,10771799 ! regulation of behavior GO:0050795 48 25 0,000 0,08368757 0,10766126 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,08368757 0,1076046 ! interaction with host GO:0051701 66 25 0,000 0,08368757 0,10754799 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,08368757 0,10749145 ! immunoglobulin production GO:0002377 62 25 0,000 0,08368757 0,10743496 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,08368757 0,10737854 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,08368757 0,10732217 ! liver development GO:0001889 55 25 0,000 0,08368757 0,10726586 ! protein tetramerization GO:0051262 57 25 0,000 0,08368757 0,10720962 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,0868865 0,11124933 ! myelination GO:0042552 50 26 0,000 0,0868865 0,11119105 ! initiation of viral infection GO:0019059 60 26 0,000 0,0868865 0,11113284 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,0868865 0,11107468 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,0868865 0,11101659 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,0868865 0,11095856 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,0868865 0,11090059 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,0868865 0,11084267 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,0868865 0,11078482 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,0868865 0,11072703 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,0868865 0,1106693 ! digestive system process GO:0022600 49 26 0,000 0,0868865 0,11061163 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,0868865 0,11055402 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,0868865 0,11049647 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 0,000 0,0868865 0,11043898 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,0868865 0,11038155 ! osteoblast differentiation GO:0001649 63 26 0,000 0,0868865 0,11032418 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,0868865 0,11026687 ! neural crest cell development GO:0014032 59 26 0,000 0,0868865 0,11020962 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,0868865 0,11015242 ! negative regulation of cell development GO:0010721 83 26 0,000 0,0868865 0,11009529 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,0868865 0,11003822 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,0868865 0,1099812 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,0868865 0,10992425 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,0868865 0,10986735 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,0868865 0,10981051 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,0868865 0,10975373 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,0868865 0,10969701 GO:0045840|positive regulation of mitosis, ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,0868865 0,10964035 ! blastocyst development GO:0001824 50 26 0,000 0,0868865 0,10958375 ! telomere organization GO:0032200 46 26 0,000 0,0868865 0,1095272 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,0868865 0,10947072 ! neural tube closure GO:0001843 58 26 0,000 0,0868865 0,10941429 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,0868865 0,10935792 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,0868865 0,10930161 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,0868865 0,10924535 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,09007435 0,11319529 ! embryonic pattern specification GO:0009880 49 27 0,000 0,09007435 0,11313709 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,09007435 0,11307895 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,09007435 0,11302087 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,09007435 0,11296285 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,09007435 0,11290489 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,09007435 0,11284699 ! iron ion transport GO:0006826 65 27 0,000 0,09007435 0,11278915 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,09007435 0,11273137 ! superoxide metabolic process GO:0006801 41 27 0,000 0,09007435 0,11267365 ! tube lumen formation GO:0035148 59 27 0,000 0,09007435 0,11261599 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,09007435 0,11255838 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,09007435 0,11250084 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,09007435 0,11244335 ! response to starvation GO:0042594 47 27 0,000 0,09007435 0,11238592 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,09007435 0,11232855 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,09007435 0,11227124 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,09007435 0,11221399 ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,09007435 0,1121568 ! neuron fate commitment GO:0048663 52 28 0,000 0,09325116 0,11605328 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 0,000 0,09325116 0,11599419 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,09325116 0,11593516 ! protein amino acid acylation GO:0043543 59 28 0,000 0,09325116 0,11587619 ! vesicle docking GO:0048278 55 28 0,000 0,09325116 0,11581728 ! circadian rhythm GO:0007623 56 28 0,000 0,09325116 0,11575843 ! dendrite development GO:0016358 67 28 0,000 0,09325116 0,11569964 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,09325116 0,11564091 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,09325116 0,11558224 ! sperm motility GO:0030317 37 28 0,000 0,09325116 0,11552362 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,09325116 0,11546507 ! base-excision repair GO:0006284 41 28 0,000 0,09325116 0,11540658 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,09325116 0,11534815 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,09325116 0,11528977 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,09325116 0,11523146 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,09325116 0,1151732 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,09325116 0,115115 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,09325116 0,11505686 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,09325116 0,11499878 ! glutathione metabolic process GO:0006749 42 28 0,000 0,09325116 0,11494076 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,09325116 0,1148828 ! lipid oxidation GO:0034440 48 28 0,000 0,09325116 0,11482489 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,09325116 0,11476705 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,09325116 0,11470926 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,09641697 0,11854386 ! translational initiation GO:0006413 66 29 0,000 0,09641697 0,11848423 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,09641697 0,11842466 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,09641697 0,11836515 ! autophagy GO:0006914 47 29 0,000 0,09641697 0,1183057 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,09641697 0,11824631 ! primary neural tube formation GO:0014020 61 29 0,000 0,09641697 0,11818698 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,09641697 0,11812771 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,09641697 0,1180685 ! somitogenesis GO:0001756 52 29 0,000 0,09641697 0,11800935 ! synaptogenesis GO:0007416 46 29 0,000 0,09641697 0,11795025 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,09641697 0,11789122 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,09641697 0,11783224 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,09641697 0,11777333 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,09957181 0,12156619 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,09957181 0,12150547 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,09957181 0,1214448 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,09957181 0,1213842 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,09957181 0,12132366 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,09957181 0,12126318 ! acute-phase response GO:0006953 50 30 0,000 0,09957181 0,12120276 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,09957181 0,1211424 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,09957181 0,1210821 ! myofibril assembly GO:0030239 50 30 0,000 0,09957181 0,12102186 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,09957181 0,12096168 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,09957181 0,12090156 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,09957181 0,1208415 ! cell fate determination GO:0001709 64 30 0,000 0,09957181 0,1207815 ! phospholipid transport GO:0015914 65 30 0,000 0,09957181 0,12072156 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,09957181 0,12066168 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,09957181 0,12060186 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,09957181 0,12054209 ! regulation of B cell activation GO:0050864 55 30 0,000 0,09957181 0,12048239 ! regulation of coagulation GO:0050818 52 30 0,000 0,09957181 0,12042274 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,10271573 0,12416355 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,10271573 0,12410214 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,10271573 0,1240408 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,10271573 0,12397951 ! regulation of innate immune response GO:0045088 57 31 0,000 0,10271573 0,12391829 ! peptide transport GO:0015833 60 31 0,000 0,10271573 0,12385712 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,10271573 0,12379602 ! detection of light stimulus GO:0009583 44 31 0,000 0,10271573 0,12373498 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,10271573 0,12367399 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,10271573 0,12361307 ! natural killer cell activation GO:0030101 50 31 0,000 0,10271573 0,12355221 ! ensheathment of neurons GO:0007272 64 31 0,000 0,10271573 0,1234914 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,10271573 0,12343066 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,10271573 0,12336998 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,10271573 0,12330935 ! eye morphogenesis GO:0048592 65 31 0,000 0,10271573 0,12324879 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,10271573 0,12318828 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,10584876 0,12688348 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,10584876 0,12682125 ! collagen metabolic process GO:0032963 49 32 0,000 0,10584876 0,12675908 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,10584876 0,12669697 ! spindle organization GO:0007051 50 32 0,000 0,10584876 0,12663493 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,10584876 0,12657294 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,10584876 0,12651102 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,10584876 0,12644916 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,10584876 0,12638735 ! muscle cell development GO:0055001 52 32 0,000 0,10584876 0,12632561 ! mesoderm formation GO:0001707 73 32 0,000 0,10584876 0,12626393 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,10584876 0,1262023 ! peripheral nervous system development GO:0007422 68 32 0,000 0,10584876 0,12614074 ! BMP signaling pathway GO:0030509 71 32 0,000 0,10584876 0,12607924 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,10584876 0,1260178 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,10584876 0,12595642 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,10584876 0,12589509 ! gene silencing GO:0016458 71 32 0,000 0,10584876 0,12583383 ! regulation of pH GO:0006885 56 33 0,000 0,10897094 0,12948249 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,10897094 0,12941954 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,10897094 0,12935666 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,10897094 0,12929383 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,10897094 0,12923107 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,10897094 0,12916837 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,10897094 0,12910572 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,10897094 0,12904314 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,10897094 0,12898062 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,10897094 0,12891816 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,10897094 0,12885576 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,10897094 0,12879342 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,10897094 0,12873114 ! glial cell differentiation GO:0010001 67 34 0,000 0,1120823 0,13234271 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,1120823 0,13227877 ! cholesterol transport GO:0030301 62 34 0,000 0,1120823 0,1322149 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,1120823 0,13215109 ! spliceosome assembly GO:0000245 75 34 0,000 0,1120823 0,13208734 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,1120823 0,13202365 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,1120823 0,13196003 ! formation of primary germ layer GO:0001704 76 34 0,000 0,1120823 0,13189646 ! cell fate specification GO:0001708 56 34 0,000 0,1120823 0,13183296 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,1120823 0,13176952 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,1120823 0,13170614 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,1120823 0,13164282 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,11518289 0,13521951 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,11518289 0,13515456 ! negative regulation of secretion GO:0051048 68 35 0,000 0,11518289 0,13508967 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,11518289 0,13502485 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,11518289 0,13496009 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,11518289 0,13489539 ! membrane docking GO:0022406 69 35 0,000 0,11518289 0,13483076 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,11518289 0,13476618 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,11518289 0,13470167 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,11518289 0,13463722 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,11518289 0,13457283 ! ceramide metabolic process GO:0006672 72 35 0,000 0,11518289 0,1345085 ! telencephalon development GO:0021537 81 35 0,000 0,11518289 0,13444424 ! sterol transport GO:0015918 63 35 0,000 0,11518289 0,13438003 ! calcium-mediated signaling GO:0019722 67 35 0,000 0,11518289 0,13431589 ! placenta development GO:0001890 53 35 0,000 0,11518289 0,13425181 ! vesicle localization GO:0051648 70 35 0,000 0,11518289 0,13418779 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,11827273 0,13772177 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,11827273 0,13765616 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,11827273 0,13759061 ! protein targeting to membrane GO:0006612 75 36 0,000 0,11827273 0,13752512 ! regulation of proteolysis GO:0030162 77 36 0,000 0,11827273 0,1374597 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,11827273 0,13739433 ! aerobic respiration GO:0009060 56 36 0,000 0,11827273 0,13732903 ! cytokine production GO:0001816 68 36 0,000 0,11827273 0,13726379 ! embryonic organ development GO:0048568 67 36 0,000 0,11827273 0,13719862 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,11827273 0,1371335 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,11827273 0,13706845 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,12135187 0,14057024 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,12135187 0,14050361 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,12135187 0,14043706 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,12135187 0,14037056 ! odontogenesis GO:0042476 74 37 0,000 0,12135187 0,14030413 ! actomyosin structure organization GO:0031032 68 37 0,000 0,12135187 0,14023776 ! tissue remodeling GO:0048771 78 37 0,000 0,12135187 0,14017146 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,12135187 0,14010521 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,12135187 0,14003903 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,12135187 0,13997291 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,12135187 0,13990686 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,12442035 0,14337685 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,12442035 0,14330925 ! organic anion transport GO:0015711 82 38 0,000 0,12442035 0,14324171 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,12442035 0,14317424 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,12442035 0,14310683 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,12442035 0,14303949 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,12442035 0,14297221 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,12442035 0,14290499 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,12442035 0,14283784 ! spermatid development GO:0007286 69 38 0,000 0,12442035 0,14277074 ! neural tube formation GO:0001841 79 38 0,000 0,12442035 0,14270372 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,1274782 0,1461423 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,1274782 0,14607375 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,1274782 0,14600527 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,1274782 0,14593685 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,1274782 0,14586849 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,1274782 0,1458002 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,1274782 0,14573198 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,1274782 0,14566381 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,1274782 0,14559571 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,13052545 0,14900639 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,13052545 0,14893679 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,13052545 0,14886726 ! learning GO:0007612 82 40 0,000 0,13052545 0,14879779 ! nucleus organization GO:0006997 73 40 0,000 0,13052545 0,14872839 ! lipid homeostasis GO:0055088 75 40 0,000 0,13052545 0,14865905 ! mismatch repair GO:0006298 58 40 0,000 0,13052545 0,14858978 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,13052545 0,14852057 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,13052545 0,14845143 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,13052545 0,14838235 ! RNA export from nucleus GO:0006405 61 41 0,000 0,13356214 0,15176387 ! mRNA catabolic process GO:0006402 79 41 0,000 0,13356214 0,15169331 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,13356214 0,15162282 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,13356214 0,1515524 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,13356214 0,15148204 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,13356214 0,15141175 ! feeding behavior GO:0007631 69 41 0,000 0,13356214 0,15134152 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,13356214 0,15127136 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,13356214 0,15120126 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,13356214 0,15113123 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,13356214 0,15106126 ! spermatid differentiation GO:0048515 73 41 0,000 0,13356214 0,15099135 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,13356214 0,15092152 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,13658832 0,15426965 ! ear morphogenesis GO:0042471 64 42 0,000 0,13658832 0,15419837 ! organic ether metabolic process GO:0018904 59 42 0,000 0,13658832 0,15412714 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,13658832 0,15405598 ! regulation of intracellular protein transport GO:0033157 86 42 0,000 0,13658832 0,15398489 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,13658832 0,15391387 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,13658832 0,15384291 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,13658832 0,15377201 ! regulation of protein secretion GO:0050708 77 42 0,000 0,13658832 0,15370118 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,13658832 0,15363042 ! cytokinesis GO:0000910 84 42 0,000 0,13658832 0,15355972 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,13658832 0,15348908 ! positive regulation of transcription factor activity GO:0051091 71 43 0,000 0,13960401 0,15680579 GO:0090047|positive regulation of transcription regulator activity, ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,13960401 0,15673373 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,13960401 0,15666173 ! regulation of tube size GO:0035150 76 43 0,000 0,13960401 0,1565898 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,13960401 0,15651794 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,13960401 0,15644614 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,13960401 0,15637441 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,13960401 0,15630275 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,13960401 0,15623115 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,13960401 0,15615961 ! segmentation GO:0035282 78 43 0,000 0,13960401 0,15608814 ! ion transmembrane transport GO:0034220 79 43 0,000 0,13960401 0,15601674 ! neuron migration GO:0001764 85 43 0,000 0,13960401 0,1559454 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,14260925 0,15922962 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,14260925 0,15915688 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,14260925 0,1590842 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,14260925 0,15901159 ! striated muscle contraction GO:0006941 85 44 0,000 0,14260925 0,15893905 ! phagocytosis GO:0006909 105 44 0,000 0,14260925 0,15886658 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,14260925 0,15879417 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,14560408 0,16205502 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,14560408 0,16198123 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,14560408 0,1619075 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,14560408 0,16183384 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,14560408 0,16176024 ! polyol metabolic process GO:0019751 77 45 0,000 0,14560408 0,16168671 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,14858853 0,16492585 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,14858853 0,16485095 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 0,000 0,14858853 0,16477612 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,14858853 0,16470136 ! leukocyte migration GO:0050900 75 46 0,000 0,14858853 0,16462666 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,14858853 0,16455203 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,14858853 0,16447748 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,14858853 0,16440298 ! neural tube development GO:0021915 91 47 0,000 0,15156265 0,16761772 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,15156265 0,16754188 ! positive regulation of cell cycle GO:0045787 96 48 0,000 0,15452645 0,1707409 ! positive regulation of defense response GO:0031349 88 48 0,000 0,15452645 0,17066371 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,15452645 0,17058659 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,15452645 0,17050954 ! cellular component disassembly GO:0022411 89 48 0,000 0,15452645 0,17043256 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,15452645 0,17035565 ! endosome transport GO:0016197 127 48 0,000 0,15452645 0,17027881 ! positive regulation of DNA binding GO:0043388 83 48 0,000 0,15452645 0,17020204 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,15452645 0,17012534 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,15452645 0,1700487 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,15452645 0,16997214 ! response to calcium ion GO:0051592 94 49 0,000 0,15747999 0,17314294 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,15747999 0,17306505 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,15747999 0,17298724 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,15747999 0,17290949 ! JNK cascade GO:0007254 106 49 0,000 0,15747999 0,17283181 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,15747999 0,1727542 ! regulation of ion transport GO:0043269 86 50 0,000 0,16042329 0,17590399 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,16042329 0,17582508 ! endocrine system development GO:0035270 109 50 0,000 0,16042329 0,17574623 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,16042329 0,17566746 ! activation of caspase activity GO:0006919 95 50 0,000 0,16042329 0,17558875 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,16042329 0,17551012 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,16042329 0,17543156 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,16042329 0,17535306 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,16042329 0,17527464 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,16335639 0,17839949 ! viral infectious cycle GO:0019058 104 51 0,000 0,16335639 0,17831978 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,16335639 0,17824014 ! peptide metabolic process GO:0006518 80 51 0,000 0,16335639 0,17816056 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,16335639 0,17808106 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,16335639 0,17800163 ! positive regulation of binding GO:0051099 88 52 0,000 0,16627933 0,18110584 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,16627933 0,18102513 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,16627933 0,1809445 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,16627933 0,18086394 ! excretion GO:0007588 87 52 0,000 0,16627933 0,18078344 ! histone modification GO:0016570 104 52 0,000 0,16627933 0,18070302 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,16627933 0,18062268 ! amino acid activation GO:0043038 98 52 0,000 0,16627933 0,1805424 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,16919214 0,18362345 ! inner ear development GO:0048839 89 53 0,000 0,16919214 0,18354191 ! chromatin remodeling GO:0006338 122 53 0,000 0,16919214 0,18346045 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,16919214 0,18337905 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,16919214 0,18329773 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,16919214 0,18321648 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! cartilage development GO:0051216 99 53 0,000 0,16919214 0,18313531 ! synapse organization GO:0050808 102 53 0,000 0,16919214 0,1830542 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,17209485 0,18611231 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,17209485 0,18602996 ! activation of phospholipase C activity GO:0007202 110 54 0,000 0,17209485 0,18594768 GO:0010863|positive regulation of phospholipase C activity, ! embryonic skeletal system development GO:0048706 101 54 0,000 0,17209485 0,18586548 ! membrane fusion GO:0006944 122 54 0,000 0,17209485 0,18578335 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,17209485 0,18570129 ! covalent chromatin modification GO:0016569 115 54 0,000 0,17209485 0,1856193 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,17209485 0,18553739 ! regulation of cell shape GO:0008360 142 54 0,000 0,17209485 0,18545554 ! RNA catabolic process GO:0006401 103 55 0,000 0,1749875 0,18848962 ! positive regulation of phospholipase activity GO:0010518 111 55 0,000 0,1749875 0,18840655 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,1749875 0,18832355 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,1749875 0,18824063 ! cell recognition GO:0008037 98 55 0,000 0,1749875 0,18815778 ! cell maturation GO:0048469 107 55 0,000 0,1749875 0,188075 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,1749875 0,18799229 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,17787013 0,19100515 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,17787013 0,19092123 ! regulation of DNA replication GO:0006275 105 56 0,000 0,17787013 0,19083738 ! chloride transport GO:0006821 102 57 0,000 0,18074276 0,19383432 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,18074276 0,19374926 GO:0010952|positive regulation of peptidase activity, ! regulation of phospholipase activity GO:0010517 113 57 0,000 0,18074276 0,19366429 ! heart morphogenesis GO:0003007 105 57 0,000 0,18074276 0,19357938 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,18074276 0,19349455 ! regulation of intracellular transport GO:0032386 108 57 0,000 0,18074276 0,1934098 ! regulation of actin filament length GO:0030832 118 58 0,000 0,18360544 0,19638708 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,18360544 0,19630114 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,18360544 0,19621527 ! gastrulation GO:0007369 122 58 0,000 0,18360544 0,19612947 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,18360544 0,19604375 ! positive regulation of lipase activity GO:0060193 115 58 0,000 0,18360544 0,1959581 ! nuclear export GO:0051168 110 59 0,000 0,1864582 0,19891589 ! establishment of organelle localization GO:0051656 122 59 0,000 0,1864582 0,19882906 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,18930107 0,20177247 ! lipid modification GO:0030258 112 60 0,000 0,18930107 0,20168448 ! DNA catabolic process GO:0006308 94 60 0,000 0,18930107 0,20159656 ! regulation of endocytosis GO:0030100 104 60 0,000 0,18930107 0,20150872 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,18930107 0,20142095 ! regulation of cellular component size GO:0032535 125 61 0,000 0,19213408 0,20434635 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,19213408 0,20425743 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,19213408 0,20416858 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,19213408 0,20407981 ! proton transport GO:0015992 117 61 0,000 0,19213408 0,20399112 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,19213408 0,2039025 ! viral reproductive process GO:0022415 132 62 0,000 0,19495728 0,20680878 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,19495728 0,20671902 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,19495728 0,20662934 ! tRNA processing GO:0008033 102 62 0,000 0,19495728 0,20653973 ! mesoderm development GO:0007498 128 63 0,000 0,19777068 0,20942947 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,19777068 0,20933873 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,19777068 0,20924806 ! hydrogen transport GO:0006818 121 64 0,000 0,20057434 0,21212256 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,20057434 0,21203077 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,20057434 0,21193906 ! protein amino acid autophosphorylation GO:0046777 157 64 0,000 0,20057434 0,21184743 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,20336827 0,21470557 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,20336827 0,21461282 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,20336827 0,21452016 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,20615252 0,21736323 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,20615252 0,21726946 ! activation of MAPK activity GO:0000187 124 67 0,000 0,20892711 0,22009872 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,20892711 0,22000385 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,20892711 0,21990906 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,20892711 0,21981436 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,21169209 0,22262754 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,21169209 0,22253174 ! extracellular matrix organization GO:0030198 146 68 0,000 0,21169209 0,22243603 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,21169209 0,2223404 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,21169209 0,22224485 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,21169209 0,22214939 ! viral reproduction GO:0016032 142 68 0,000 0,21169209 0,222054 ! regulation of lipase activity GO:0060191 137 68 0,000 0,21169209 0,2219587 ! adaptive immune response GO:0002250 126 68 0,000 0,21169209 0,22186348 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,21169209 0,22176834 ! cell projection assembly GO:0030031 138 68 0,000 0,21169209 0,22167329 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,21444748 0,22446238 ! negative regulation of protein kinase activity GO:0006469 144 69 0,000 0,21444748 0,22436625 ! lung development GO:0030324 165 69 0,000 0,21444748 0,2242702 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,21444748 0,22417424 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 0,000 0,21444748 0,22407835 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,21444748 0,22398255 ! single fertilization GO:0007338 83 69 0,000 0,21444748 0,22388683 ! negative regulation of kinase activity GO:0033673 145 70 0,000 0,21719331 0,22665667 ! cell redox homeostasis GO:0045454 114 70 0,000 0,21719331 0,22655989 ! activation of immune response GO:0002253 120 70 0,000 0,21719331 0,22646319 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,21992963 0,22921847 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,21992963 0,22912072 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,21992963 0,22902305 ! appendage morphogenesis GO:0035107 150 72 0,000 0,22265646 0,23176383 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 171 72 0,000 0,22265646 0,23166513 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,22265646 0,2315665 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,22265646 0,23146797 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,22265646 0,23136951 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,22265646 0,23127114 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,22265646 0,23117285 ! appendage development GO:0048736 151 73 0,000 0,22537383 0,23389476 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,22537383 0,23379544 ! regulation of immune effector process GO:0002697 156 73 0,000 0,22537383 0,2336962 ! acute inflammatory response GO:0002526 118 74 0,000 0,22808178 0,23640381 ! amino acid transport GO:0006865 148 74 0,000 0,22808178 0,23630355 ! regulation of caspase activity GO:0043281 136 74 0,000 0,22808178 0,23620338 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,22808178 0,2361033 ! negative regulation of transferase activity GO:0051348 155 74 0,000 0,22808178 0,23600329 ! respiratory system development GO:0060541 175 74 0,000 0,22808178 0,23590338 ! organelle localization GO:0051640 155 74 0,000 0,22808178 0,23580355 ! transition metal ion transport GO:0000041 143 75 0,000 0,23078033 0,23849254 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,23078033 0,23839169 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,23078033 0,23829094 ! axon guidance GO:0007411 162 75 0,000 0,23078033 0,23819026 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,23346953 0,24086405 ! learning or memory GO:0007611 161 76 0,000 0,23346953 0,24076238 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,23346953 0,24066079 ! amine catabolic process GO:0009310 136 77 0,000 0,23614941 0,24332054 ! neurotransmitter transport GO:0006836 142 77 0,000 0,23614941 0,24321796 ! phosphoinositide metabolic process GO:0030384 146 77 0,000 0,23614941 0,24311547 ! regulation of endopeptidase activity GO:0052548 141 77 0,000 0,23614941 0,24301306 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,23614941 0,24291074 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,23614941 0,2428085 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,23614941 0,24270635 ! regulation of catabolic process GO:0009894 173 77 0,000 0,23614941 0,24260429 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,23881999 0,24524474 ! antigen processing and presentation GO:0019882 117 78 0,000 0,23881999 0,24514169 ! fertilization GO:0009566 99 78 0,000 0,23881999 0,24503874 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,23881999 0,24493587 ! blood coagulation GO:0007596 151 79 0,000 0,24148131 0,24756141 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,24148131 0,24745756 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,24148131 0,24735381 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,24148131 0,24725014 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,24148131 0,24714656 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,2441334 0,24975623 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,2441334 0,24965169 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,2441334 0,24954723 ! positive regulation of phosphorylation GO:0042327 149 81 0,000 0,24677629 0,25214323 ! regulation of peptidase activity GO:0052547 150 82 0,000 0,24941001 0,2547277 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,2520346 0,25730068 ! exocytosis GO:0006887 153 83 0,000 0,2520346 0,2571932 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,2520346 0,25708581 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 0,000 0,2520346 0,25697851 GO:0045937|positive regulation of phosphate metabolic process, ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,2520346 0,25687131 ! inorganic anion transport GO:0015698 156 83 0,000 0,2520346 0,25676419 ! digestion GO:0007586 130 84 0,000 0,25465008 0,25932061 ! regulation of ligase activity GO:0051340 147 84 0,000 0,25465008 0,25921256 ! hemostasis GO:0007599 165 85 0,000 0,25725649 0,26175661 ! negative regulation of transport GO:0051051 164 85 0,000 0,25725649 0,26164763 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,25725649 0,26153875 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,25725649 0,26142996 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,25725649 0,26132125 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,25985387 0,26384996 ! regulation of lyase activity GO:0051339 169 86 0,000 0,25985387 0,26374034 ! positive regulation of cell activation GO:0050867 161 86 0,000 0,25985387 0,26363081 GO:0002696|positive regulation of leukocyte activation, ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,26244223 0,26614627 ! nucleosome assembly GO:0006334 126 87 0,000 0,26244223 0,26603584 ! regulation of protein transport GO:0051223 165 87 0,000 0,26244223 0,26592549 GO:0070201|regulation of establishment of protein localization, ! cellular respiration GO:0045333 143 88 0,000 0,26502161 0,26842778 ! sensory perception of smell GO:0007608 117 88 0,000 0,26502161 0,26831653 ! chromatin assembly GO:0031497 128 88 0,000 0,26502161 0,26820538 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,26759204 0,27069456 ! cellular defense response GO:0006968 123 89 0,000 0,26759204 0,27058252 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,27015356 0,27305964 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,27015356 0,27294671 ! response to unfolded protein GO:0006986 139 90 0,000 0,27015356 0,27283388 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,27270619 0,27529803 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! ossification GO:0001503 205 91 0,000 0,27270619 0,27518432 ! defense response to bacterium GO:0042742 112 91 0,000 0,27270619 0,2750707 ! bone development GO:0060348 206 92 0,000 0,27524997 0,27752194 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,27524997 0,27740745 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,27778492 0,27984682 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,27778492 0,27973147 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,27778492 0,27961621 ! positive regulation of MAP kinase activity GO:0043406 174 93 0,000 0,27778492 0,27950105 ! vitamin metabolic process GO:0006766 153 93 0,000 0,27778492 0,27938598 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,28031107 0,28181068 ! sterol metabolic process GO:0016125 166 94 0,000 0,28031107 0,28169475 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,28031107 0,28157892 ! nucleosome organization GO:0034728 143 95 0,000 0,28282846 0,28399093 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,28282846 0,28387425 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,28282846 0,28375767 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,28282846 0,28364118 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,28282846 0,28352479 ! regulation of T cell activation GO:0050863 175 96 0,000 0,28533711 0,2859223 ! forebrain development GO:0030900 210 98 0,000 0,29032833 0,29080448 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,29032833 0,2906853 ! mRNA transport GO:0051028 185 100 0,000 0,29528498 0,29552692 ! positive regulation of immune response GO:0050778 175 100 0,000 0,29528498 0,2954059 ! hormone metabolic process GO:0042445 171 100 0,000 0,29528498 0,29528498