pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1258-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! positive regulation of epithelial cell proliferation GO:0050679 37 19 3,000 2,047E-07 4,707E-04 ! positive regulation of glycolysis GO:0045821 11 5 2,000 2,061E-07 2,37E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 2,553E-07 1,957E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 5,553E-07 3,193E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,147E-06 5,278E-04 ! positive regulation of glucose metabolic process GO:0010907 15 9 2,000 1,718E-06 6,585E-04 ! regulation of glycolysis GO:0006110 15 9 2,000 1,718E-06 5,644E-04 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 2,374E-06 6,826E-04 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 2,000 2,449E-06 6,259E-04 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 4,168E-06 9,586E-04 ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 4,472E-06 9,351E-04 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 2,000 4,472E-06 8,572E-04 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of gene-specific transcription GO:0032583 69 43 3,000 6,202E-06 1,097E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 6,202E-06 1,019E-03 ! positive regulation of cell cycle GO:0045787 77 45 3,000 7,457E-06 1,143E-03 ! regulation of glucose metabolic process GO:0010906 22 16 2,000 1,129E-05 1,624E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 1,129E-05 1,528E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 1,235E-05 1,579E-03 ! positive regulation of organelle organization GO:0010638 82 51 3,000 1,235E-05 1,495E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 1,369E-05 1,574E-03 ! positive regulation of DNA replication GO:0045740 29 18 2,000 1,639E-05 1,795E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 1,797E-05 1,879E-03 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 1,929E-05 1,929E-03 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 1,943E-05 1,862E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of cellular catabolic process GO:0031329 36 24 2,000 4,018E-05 3,697E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 4,018E-05 3,555E-03 ! positive regulation of nuclear division GO:0051785 39 25 2,000 4,557E-05 3,882E-03 GO:0045840|positive regulation of mitosis, ! cellular response to hormone stimulus GO:0032870 109 74 3,000 5,425E-05 4,456E-03 ! positive regulation of catabolic process GO:0009896 40 28 2,000 6,453E-05 5,118E-03 ! positive regulation of vasoconstriction GO:0045907 9 5 1,000 7,655E-05 5,869E-03 ! muscle cell proliferation GO:0033002 8 5 1,000 7,655E-05 5,679E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 7,655E-05 5,502E-03 ! regulation of muscle cell apoptosis GO:0010660 8 5 1,000 7,655E-05 5,335E-03 ! somatic stem cell maintenance GO:0035019 13 5 1,000 7,655E-05 5,178E-03 ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 7,655E-05 5,03E-03 ! mammary gland development GO:0030879 57 31 2,000 8,802E-05 5,623E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 9,333E-05 5,802E-03 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 1,064E-04 6,441E-03 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 1,000 1,146E-04 6,76E-03 ! male sex determination GO:0030238 9 6 1,000 1,146E-04 6,591E-03 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 1,000 1,146E-04 6,43E-03 ! gas homeostasis GO:0033483 11 6 1,000 1,146E-04 6,277E-03 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 1,146E-04 6,131E-03 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 1,146E-04 5,991E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,602E-04 8,187E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,602E-04 8,009E-03 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 1,602E-04 7,839E-03 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 1,602E-04 7,675E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! vesicle fusion GO:0006906 15 7 1,000 1,602E-04 7,519E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 1,602E-04 7,368E-03 ! cardiac muscle cell differentiation GO:0055007 12 7 1,000 1,602E-04 7,224E-03 ! muscle adaptation GO:0043500 12 7 1,000 1,602E-04 7,085E-03 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 1,000 2,132E-04 9,252E-03 GO:0046579|positive regulation of Ras protein signal transduction, ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 2,132E-04 9,08E-03 ! multicellular organism growth GO:0035264 14 8 1,000 2,132E-04 8,915E-03 ! nucleosome disassembly GO:0006337 12 8 1,000 2,132E-04 8,756E-03 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! induction of an organ GO:0001759 11 8 1,000 2,132E-04 8,602E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 2,132E-04 8,454E-03 ! regulation of JAK-STAT cascade GO:0046425 61 42 2,000 2,2E-04 8,575E-03 ! regulation of gene expression, epigenetic GO:0040029 72 42 2,000 2,2E-04 8,432E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 2,703E-04 0,01019161 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 2,736E-04 0,01015003 ! regulation of developmental growth GO:0048638 13 9 1,000 2,736E-04 9,989E-03 ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 2,736E-04 9,833E-03 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 2,736E-04 9,682E-03 GO:0010469|regulation of receptor activity, ! retinoic acid receptor signaling pathway GO:0048384 15 9 1,000 2,736E-04 9,535E-03 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 2,736E-04 9,393E-03 ! localization within membrane GO:0051668 15 9 1,000 2,736E-04 9,254E-03 ! heart morphogenesis GO:0003007 65 48 2,000 3,275E-04 0,01091748 ! regulation of DNA replication GO:0006275 75 48 2,000 3,275E-04 0,01076152 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 3,414E-04 0,01105942 ! cardiac cell differentiation GO:0035051 16 10 1,000 3,414E-04 0,01090582 ! developmental induction GO:0031128 13 10 1,000 3,414E-04 0,01075642 GO:0045168|cell-cell signaling involved in cell fate specification, ! virus-host interaction GO:0019048 17 11 1,000 4,165E-04 0,01294587 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 4,165E-04 0,01277326 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 1,000 4,165E-04 0,01260519 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! stem cell development GO:0048864 29 11 1,000 4,165E-04 0,01244148 GO:0019827|stem cell maintenance, ! lysogeny GO:0030069 18 11 1,000 4,165E-04 0,01228198 GO:0019047|provirus integration, ! regulation of mitosis GO:0007088 84 54 2,000 4,642E-04 0,01351431 GO:0051783|regulation of nuclear division, ! gland morphogenesis GO:0022612 23 12 1,000 4,989E-04 0,0143442 ! viral reproductive process GO:0022415 87 58 2,000 5,729E-04 0,01626812 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 5,886E-04 0,01650917 ! lipid localization GO:0010876 24 13 1,000 5,886E-04 0,01631027 GO:0019915|lipid storage, ! organelle fusion GO:0048284 28 13 1,000 5,886E-04 0,0161161 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 5,886E-04 0,0159265 ! tissue regeneration GO:0042246 21 13 1,000 5,886E-04 0,0157413 ! activation of MAPK activity GO:0000187 84 59 2,000 6,024E-04 0,01592624 ! extracellular matrix organization GO:0030198 103 61 2,000 6,643E-04 0,01736283 ! myotube differentiation GO:0014902 21 14 1,000 6,855E-04 0,01771407 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 6,855E-04 0,01751725 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 6,855E-04 0,01732475 ! DNA unwinding during replication GO:0006268 21 14 1,000 6,855E-04 0,01713644 ! water homeostasis GO:0030104 24 14 1,000 6,855E-04 0,01695217 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 7,301E-04 0,01786476 ! viral reproduction GO:0016032 92 63 2,000 7,301E-04 0,01767671 ! lipid phosphorylation GO:0046834 23 15 1,000 7,895E-04 0,01891505 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 7,895E-04 0,01872005 ! myoblast differentiation GO:0045445 27 15 1,000 7,895E-04 0,01852903 ! DNA integration GO:0015074 22 15 1,000 7,895E-04 0,01834187 ! regulation of vasodilation GO:0042312 24 15 1,000 7,895E-04 0,01815845 ! protein oligomerization GO:0051259 100 65 2,000 7,999E-04 0,01821665 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 1,000 9,007E-04 0,02030922 ! positive regulation of phosphorylation GO:0042327 102 70 2,000 9,927E-04 0,0221671 ! regulation of catabolic process GO:0009894 106 70 2,000 9,927E-04 0,02195396 ! inactivation of MAPK activity GO:0000188 27 17 1,000 1,019E-03 0,0223195 ! DNA duplex unwinding GO:0032508 25 17 1,000 1,019E-03 0,02210894 GO:0032392|DNA geometric change, ! cellular macromolecular complex disassembly GO:0034623 29 17 1,000 1,019E-03 0,02190232 ! stem cell differentiation GO:0048863 36 17 1,000 1,019E-03 0,02169952 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 1,000 1,019E-03 0,02150044 ! muscle cell differentiation GO:0042692 104 71 2,000 1,034E-03 0,02162968 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 2,000 1,077E-03 0,02232288 GO:0045937|positive regulation of phosphate metabolic process, ! response to retinoic acid GO:0032526 25 18 1,000 1,144E-03 0,02349802 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 1,144E-03 0,02329007 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 1,277E-03 0,02575563 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 1,277E-03 0,02553167 ! regeneration GO:0031099 32 19 1,000 1,277E-03 0,02531157 ! response to vitamin A GO:0033189 26 19 1,000 1,277E-03 0,02509523 ! sex determination GO:0007530 29 19 1,000 1,277E-03 0,02488256 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 1,277E-03 0,02467346 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 1,277E-03 0,02446785 ! gland development GO:0048732 148 77 2,000 1,308E-03 0,02487147 ! response to vitamin GO:0033273 29 20 1,000 1,416E-03 0,02669304 ! collagen fibril organization GO:0030199 45 20 1,000 1,416E-03 0,02647602 ! regulation of cell cycle process GO:0010564 122 81 2,000 1,514E-03 0,02808617 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 1,562E-03 0,02874332 ! vesicle docking GO:0048278 27 21 1,000 1,562E-03 0,0285152 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 1,000 1,562E-03 0,02829067 GO:0060415|muscle tissue morphogenesis, ! regulation of vasoconstriction GO:0019229 31 21 1,000 1,562E-03 0,02806965 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 1,715E-03 0,03058253 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 1,715E-03 0,03034728 ! macromolecular complex disassembly GO:0032984 38 22 1,000 1,715E-03 0,03011562 ! vasculogenesis GO:0001570 33 22 1,000 1,715E-03 0,02988747 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 1,715E-03 0,02966275 ! membrane depolarization GO:0051899 35 22 1,000 1,715E-03 0,02944139 ! proteoglycan biosynthetic process GO:0030166 32 22 1,000 1,715E-03 0,02922331 ! regulation of blood coagulation GO:0030193 34 22 1,000 1,715E-03 0,02900843 ! protein tetramerization GO:0051262 39 22 1,000 1,715E-03 0,02879669 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 1,739E-03 0,02898689 ! skeletal muscle tissue development GO:0007519 123 87 2,000 1,859E-03 0,03076258 GO:0060538|skeletal muscle organ development, ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 1,875E-03 0,03080827 ! interaction with host GO:0051701 37 23 1,000 1,875E-03 0,03058977 ! initiation of viral infection GO:0019059 42 24 1,000 2,042E-03 0,03307649 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 2,042E-03 0,03284518 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 2,042E-03 0,03261709 ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 2,216E-03 0,03514599 ! regulation of chromosome organization GO:0033044 35 25 1,000 2,216E-03 0,03490527 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 2,216E-03 0,03466782 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 2,396E-03 0,03723645 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 2,396E-03 0,03698655 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 2,396E-03 0,03673997 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 2,396E-03 0,03649666 ! regulation of coagulation GO:0050818 39 26 1,000 2,396E-03 0,03625655 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 2,462E-03 0,0370144 ! proteoglycan metabolic process GO:0006029 41 27 1,000 2,583E-03 0,03857956 ! membrane docking GO:0022406 39 27 1,000 2,583E-03 0,03833066 ! extracellular structure organization GO:0043062 156 99 2,000 2,687E-03 0,03961827 ! cholesterol homeostasis GO:0042632 46 28 1,000 2,777E-03 0,04068061 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 1,000 2,777E-03 0,04042314 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 2,777E-03 0,0401689 ! cholesterol transport GO:0030301 46 30 1,000 3,184E-03 0,04577346 GO:0015918|sterol transport, ! regulation of microtubule-based process GO:0032886 58 30 1,000 3,184E-03 0,04548916 ! glial cell differentiation GO:0010001 55 31 1,000 3,398E-03 0,04824 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 3,398E-03 0,04794405 ! cell fate specification GO:0001708 37 31 1,000 3,398E-03 0,0476517 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 3,618E-03 0,05043036 ! neutral lipid metabolic process GO:0006638 41 32 1,000 3,618E-03 0,05012656 GO:0006639|acylglycerol metabolic process, ! calcium-mediated signaling GO:0019722 50 32 1,000 3,618E-03 0,0498264 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 3,618E-03 0,04952981 ! carbohydrate homeostasis GO:0033500 39 33 1,000 3,844E-03 0,05231987 GO:0042593|glucose homeostasis, ! lipid homeostasis GO:0055088 55 33 1,000 3,844E-03 0,0520121 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 4,077E-03 0,05484176 ! mRNA catabolic process GO:0006402 48 34 1,000 4,077E-03 0,05452292 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 4,077E-03 0,05420775 ! glycerol ether metabolic process GO:0006662 44 34 1,000 4,077E-03 0,05389622 ! protein homooligomerization GO:0051260 52 35 1,000 4,317E-03 0,05673473 ! organic ether metabolic process GO:0018904 46 36 1,000 4,563E-03 0,05962432 ! tissue remodeling GO:0048771 62 36 1,000 4,563E-03 0,05928746 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 4,815E-03 0,06221219 ! gliogenesis GO:0042063 71 38 1,000 5,073E-03 0,06518526 ! striated muscle cell differentiation GO:0051146 54 38 1,000 5,073E-03 0,06482312 ! developmental growth GO:0048589 62 39 1,000 5,338E-03 0,06782858 ! cell growth GO:0016049 61 39 1,000 5,338E-03 0,06745589 ! cellular component disassembly GO:0022411 64 42 1,000 6,169E-03 0,0775361 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 6,169E-03 0,07711471 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 6,459E-03 0,0802961 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 6,459E-03 0,0798644 ! vesicle organization GO:0016050 79 43 1,000 6,459E-03 0,07943732 ! RNA catabolic process GO:0006401 64 45 1,000 7,056E-03 0,08631958 ! response to UV GO:0009411 75 46 1,000 7,363E-03 0,08960609 ! viral infectious cycle GO:0019058 71 47 1,000 7,677E-03 0,09293049 ! regulation of protein polymerization GO:0032271 71 47 1,000 7,677E-03 0,09244394 ! regulation of muscle contraction GO:0006937 69 48 1,000 7,996E-03 0,09579025 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 7,996E-03 0,09529392 ! sulfur compound biosynthetic process GO:0044272 62 49 1,000 8,322E-03 0,09866121 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 8,322E-03 0,09815526 ! skeletal muscle fiber development GO:0048741 73 50 1,000 8,653E-03 0,10154264 ! membrane fusion GO:0006944 80 50 1,000 8,653E-03 0,10102719 ! lipid modification GO:0030258 73 50 1,000 8,653E-03 0,10051695 ! positive regulation of growth GO:0045927 67 50 1,000 8,653E-03 0,10001184 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 8,99E-03 0,10338948 ! activation of phospholipase C activity GO:0007202 87 51 1,000 8,99E-03 0,1028751 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 8,99E-03 0,10236582 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 9,333E-03 0,10574784 ! regulation of protein complex assembly GO:0043254 81 54 1,000 0,01003672 0,11315915 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,01003672 0,11260715 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,01003672 0,11206051 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,01076291 0,11958793 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 0,0111345 0,12312184 ! negative regulation of kinase activity GO:0033673 100 58 1,000 0,0115117 0,12668374 ! lung development GO:0030324 94 59 1,000 0,01189448 0,13027285 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,01228281 0,13388843 ! negative regulation of transferase activity GO:0051348 105 61 1,000 0,01267666 0,13752975 ! respiratory tube development GO:0030323 99 62 1,000 0,01307599 0,1411961 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,01348077 0,14488677 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01348077 0,14421288 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,01389097 0,14791311 ! respiratory system development GO:0060541 100 64 1,000 0,01389097 0,14723148 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01393766 0,14704869 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01393766 0,14637724 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01393766 0,14571189 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01393766 0,14505256 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01393766 0,14439917 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01393766 0,14375164 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01393766 0,14310989 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01393766 0,14247385 ! sleep GO:0030431 11 5 0,000 0,01393766 0,14184343 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01393766 0,14121857 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01393766 0,14059919 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01393766 0,13998522 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01393766 0,13937659 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01393766 0,13877323 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01393766 0,13817507 ! tongue development GO:0043586 6 5 0,000 0,01393766 0,13758204 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01393766 0,13699408 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01393766 0,13641113 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01393766 0,13583312 ! cobalt ion transport GO:0006824 9 5 0,000 0,01393766 0,13525998 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01393766 0,13469166 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01393766 0,1341281 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01393766 0,13356923 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01393766 0,133015 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01393766 0,13246535 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01393766 0,13192023 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01393766 0,13137957 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01393766 0,13084333 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01393766 0,13031144 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01393766 0,12978387 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01393766 0,12926055 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01393766 0,12874143 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01393766 0,12822646 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01393766 0,1277156 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01393766 0,12720879 ! malate metabolic process GO:0006108 7 5 0,000 0,01393766 0,12670599 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01393766 0,12620715 ! behavioral response to pain GO:0048266 7 5 0,000 0,01393766 0,12571222 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01393766 0,12522115 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01393766 0,12473391 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01393766 0,12425045 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01393766 0,12377072 ! mating behavior GO:0007617 6 5 0,000 0,01393766 0,12329467 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01393766 0,12282228 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01393766 0,12235349 ! rhythmic behavior GO:0007622 12 5 0,000 0,01393766 0,12188827 ! copulation GO:0007620 7 5 0,000 0,01393766 0,12142657 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01393766 0,12096836 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01393766 0,12051359 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01393766 0,12006223 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01393766 0,11961424 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01393766 0,11916957 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01393766 0,11872821 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01393766 0,11829009 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01393766 0,1178552 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01393766 0,1174235 ! response to protozoan GO:0001562 9 5 0,000 0,01393766 0,11699495 ! lymph vessel development GO:0001945 7 5 0,000 0,01393766 0,11656951 ! endochondral ossification GO:0001958 12 5 0,000 0,01393766 0,11614716 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01393766 0,11572785 ! parathyroid gland development GO:0060017 8 5 0,000 0,01393766 0,11531157 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01393766 0,11489826 ! anagen GO:0042640 6 5 0,000 0,01393766 0,11448791 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01393766 0,11408048 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01393766 0,11367594 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01393766 0,11327426 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01393766 0,11287541 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01393766 0,11247935 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01393766 0,11208607 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01393766 0,11169552 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01393766 0,11130769 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01393766 0,11092254 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01393766 0,11054005 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01393766 0,11016019 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01393766 0,10978293 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01393766 0,10940824 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01393766 0,10903611 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01393766 0,10866649 ! ovulation GO:0030728 6 5 0,000 0,01393766 0,10829938 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01393766 0,10793473 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01393766 0,10757253 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01393766 0,10721276 ! response to pH GO:0009268 9 5 0,000 0,01393766 0,10685538 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01393766 0,10650038 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01393766 0,10614773 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01393766 0,10579741 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01393766 0,10544939 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01393766 0,10510366 ! polyol catabolic process GO:0046174 7 5 0,000 0,01393766 0,10476018 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01393766 0,10441894 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01393766 0,10407992 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01393766 0,10374309 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01393766 0,10340844 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01393766 0,10307593 ! urea metabolic process GO:0019627 6 5 0,000 0,01393766 0,10274556 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01393766 0,1024173 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01393766 0,10209113 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01393766 0,10176703 ! neutrophil activation GO:0042119 5 5 0,000 0,01393766 0,10144499 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01393766 0,10112497 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01393766 0,10080697 ! response to food GO:0032094 5 5 0,000 0,01393766 0,10049096 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01393766 0,10017692 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01393766 0,09986485 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01393766 0,09955471 ! forebrain neuron development GO:0021884 7 5 0,000 0,01393766 0,09924649 ! melanosome organization GO:0032438 7 5 0,000 0,01393766 0,09894017 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01393766 0,09863574 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01393766 0,09833318 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01393766 0,09803246 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01393766 0,09773358 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01393766 0,09743652 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01393766 0,09714126 ! nucleoside transport GO:0015858 6 5 0,000 0,01393766 0,09684778 ! nucleoside salvage GO:0043174 7 5 0,000 0,01393766 0,09655607 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01393766 0,09626611 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01393766 0,09597789 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01393766 0,09569139 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01393766 0,09540659 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01393766 0,09512349 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01393766 0,09484206 ! depyrimidination GO:0045008 8 5 0,000 0,01393766 0,09456229 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01393766 0,09428416 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01393766 0,09400767 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01393766 0,09373279 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01393766 0,09345952 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01393766 0,09318784 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01393766 0,09291773 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01393766 0,09264918 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01393766 0,09238218 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01393766 0,09211671 ! monocyte differentiation GO:0030224 8 5 0,000 0,01393766 0,09185277 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01393766 0,09159033 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01393766 0,09132939 ! centrosome duplication GO:0051298 5 5 0,000 0,01393766 0,09106993 ! response to UV-C GO:0010225 6 5 0,000 0,01393766 0,09081194 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01393766 0,09055541 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01393766 0,09030032 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01393766 0,09004667 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01393766 0,08979444 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01393766 0,08954362 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01393766 0,08929419 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01393766 0,08904615 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01393766 0,08879949 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01393766 0,08855419 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01393766 0,08831024 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01393766 0,08806762 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01393766 0,08782634 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01393766 0,08758638 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01393766 0,08734773 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01393766 0,08711037 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01393766 0,0868743 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01393766 0,0866395 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01393766 0,08640597 ! neural tube patterning GO:0021532 6 5 0,000 0,01393766 0,0861737 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01393766 0,08594267 ! histone demethylation GO:0016577 9 5 0,000 0,01393766 0,08571288 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01393766 0,08548431 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01393766 0,08525696 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01393766 0,08503081 ! enteric nervous system development GO:0048484 8 5 0,000 0,01393766 0,08480586 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01393766 0,0845821 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01393766 0,08435951 ! transcription termination GO:0006353 8 5 0,000 0,01393766 0,0841381 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01393766 0,08391784 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01393766 0,08369873 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01393766 0,08348077 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01393766 0,08326394 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01393766 0,08304823 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01393766 0,08283363 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01393766 0,08262014 ! apical protein localization GO:0045176 6 5 0,000 0,01393766 0,08240775 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01393766 0,08219645 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01393766 0,08198623 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01393766 0,08177708 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01393766 0,081569 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01393766 0,08136197 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01393766 0,08115599 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01393766 0,08095105 ! glial cell migration GO:0008347 10 5 0,000 0,01393766 0,08074714 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01393766 0,08054426 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01393766 0,08034239 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01393766 0,08014154 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01393766 0,07994168 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01393766 0,07974282 ! neural plate development GO:0001840 6 5 0,000 0,01393766 0,07954495 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01393766 0,07934806 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01393766 0,07915214 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01393766 0,07895718 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01393766 0,07876318 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01393766 0,07857014 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01393766 0,07837803 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01393766 0,07818687 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01393766 0,07799663 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01393766 0,07780732 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01393766 0,07761892 ! spindle assembly GO:0051225 5 5 0,000 0,01393766 0,07743144 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01393766 0,07724486 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01393766 0,07705917 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01393766 0,07687438 ! organ regeneration GO:0031100 7 5 0,000 0,01393766 0,07669047 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01393766 0,07650744 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01393766 0,07632527 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01393766 0,07614398 GO:0055081|anion homeostasis, ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,01430656 0,07797413 ! tRNA transcription GO:0009304 11 6 0,000 0,01670227 0,09081611 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01670227 0,09060192 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01670227 0,09038874 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01670227 0,09017656 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01670227 0,08996537 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01670227 0,08975517 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01670227 0,08954595 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01670227 0,08933771 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01670227 0,08913043 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01670227 0,08892411 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01670227 0,08871874 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01670227 0,08851432 ! prostate gland development GO:0030850 9 6 0,000 0,01670227 0,08831084 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01670227 0,08810829 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01670227 0,08790667 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01670227 0,08770597 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01670227 0,08750618 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01670227 0,0873073 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01670227 0,08710933 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01670227 0,08691225 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01670227 0,08671606 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01670227 0,08652075 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01670227 0,08632632 ! neuron adhesion GO:0007158 9 6 0,000 0,01670227 0,08613277 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01670227 0,08594008 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01670227 0,08574825 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01670227 0,08555727 ! signal peptide processing GO:0006465 8 6 0,000 0,01670227 0,08536714 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01670227 0,08517786 ! mRNA stabilization GO:0048255 15 6 0,000 0,01670227 0,08498941 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01670227 0,0848018 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01670227 0,08461501 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01670227 0,08442904 ! opsonization GO:0008228 8 6 0,000 0,01670227 0,08424389 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01670227 0,08405955 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01670227 0,08387601 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01670227 0,08369328 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01670227 0,08351133 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01670227 0,08333018 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01670227 0,08314981 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01670227 0,08297022 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01670227 0,08279141 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01670227 0,08261336 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01670227 0,08243608 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01670227 0,08225956 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01670227 0,08208379 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01670227 0,08190877 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01670227 0,0817345 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01670227 0,08156096 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01670227 0,08138816 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01670227 0,0812161 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01670227 0,08104475 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01670227 0,08087413 ! thymic T cell selection GO:0045061 12 6 0,000 0,01670227 0,08070423 ! protein lipoylation GO:0009249 10 6 0,000 0,01670227 0,08053504 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01670227 0,08036656 ! pigment granule organization GO:0048753 11 6 0,000 0,01670227 0,08019878 ! drug transport GO:0015893 6 6 0,000 0,01670227 0,0800317 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01670227 0,07986531 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01670227 0,07969961 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01670227 0,0795346 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01670227 0,07937028 ! histidine metabolic process GO:0006547 6 6 0,000 0,01670227 0,07920663 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01670227 0,07904365 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01670227 0,07888134 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01670227 0,0787197 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01670227 0,07855872 ! adenohypophysis development GO:0021984 10 6 0,000 0,01670227 0,0783984 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01670227 0,07823872 ! hyperosmotic response GO:0006972 8 6 0,000 0,01670227 0,0780797 ! microtubule nucleation GO:0007020 10 6 0,000 0,01670227 0,07792133 ! ER overload response GO:0006983 7 6 0,000 0,01670227 0,07776359 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01670227 0,07760649 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01670227 0,07745003 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01670227 0,07729419 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01670227 0,07713898 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01670227 0,0769844 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01670227 0,07683043 ! response to dietary excess GO:0002021 7 6 0,000 0,01670227 0,07667707 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01670227 0,07652433 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01670227 0,07637219 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01670227 0,07622066 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01670227 0,07606973 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01670227 0,07591939 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01670227 0,07576965 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01670227 0,0756205 ! neuron apoptosis GO:0051402 8 6 0,000 0,01670227 0,07547193 ! organic alcohol transport GO:0015850 9 6 0,000 0,01670227 0,07532395 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01670227 0,07517654 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01670227 0,07502971 ! carnitine transport GO:0015879 8 6 0,000 0,01670227 0,07488346 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01670227 0,07473777 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01670227 0,07459265 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01670227 0,07444809 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01670227 0,07430409 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01670227 0,07416064 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01670227 0,07401775 ! parturition GO:0007567 12 6 0,000 0,01670227 0,07387541 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01670227 0,07373362 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01670227 0,07359236 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01670227 0,07345165 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01670227 0,07331148 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01670227 0,07317184 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01670227 0,07303273 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01670227 0,07289414 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01670227 0,07275609 ! macrophage differentiation GO:0030225 10 6 0,000 0,01670227 0,07261855 ! astrocyte development GO:0014002 14 6 0,000 0,01670227 0,07248154 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01670227 0,07234504 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01670227 0,07220905 ! interaction with symbiont GO:0051702 8 6 0,000 0,01670227 0,07207357 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01670227 0,0719386 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01670227 0,07180414 ! eating behavior GO:0042755 6 6 0,000 0,01670227 0,07167018 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01670227 0,07153671 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01670227 0,07140374 ! response to copper ion GO:0046688 9 6 0,000 0,01670227 0,07127127 ! DNA topological change GO:0006265 8 6 0,000 0,01670227 0,07113928 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01670227 0,07100779 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01670227 0,07087678 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01670227 0,07074625 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01670227 0,0706162 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01670227 0,07048663 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01670227 0,07035753 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01670227 0,07022891 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01670227 0,07010076 ! hair follicle maturation GO:0048820 7 6 0,000 0,01670227 0,06997307 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01670227 0,06984584 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01670227 0,06971908 ! Schwann cell development GO:0014044 14 6 0,000 0,01670227 0,06959278 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01670227 0,06946693 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01670227 0,06934154 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01670227 0,0692166 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01670227 0,06909211 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01670227 0,06896807 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01670227 0,06884447 ! histone ubiquitination GO:0016574 7 6 0,000 0,01670227 0,06872131 ! regulation of meiosis GO:0040020 10 6 0,000 0,01670227 0,0685986 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01670227 0,06847632 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01670227 0,06835447 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01670227 0,06823306 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01670227 0,06811208 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01670227 0,06799153 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01670227 0,0678714 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01670227 0,0677517 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01670227 0,06763242 ! receptor internalization GO:0031623 9 6 0,000 0,01670227 0,06751356 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01670227 0,06739511 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01670227 0,06727708 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01670227 0,06715946 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01670227 0,06704226 ! protein deubiquitination GO:0016579 8 6 0,000 0,01670227 0,06692546 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01670227 0,06680907 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01670227 0,06669308 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01670227 0,06657749 ! axonal fasciculation GO:0007413 9 6 0,000 0,01670227 0,06646231 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01670227 0,06634752 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01670227 0,06623313 ! midbrain development GO:0030901 6 6 0,000 0,01670227 0,06611913 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01670227 0,06600552 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01670227 0,06589231 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01670227 0,06577948 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01670227 0,06566703 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01670227 0,06555497 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01670227 0,06544329 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01670227 0,065332 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01670227 0,06522108 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01670227 0,06511053 ! adult feeding behavior GO:0008343 6 6 0,000 0,01670227 0,06500036 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01670227 0,06489056 ! blastocyst growth GO:0001832 15 6 0,000 0,01670227 0,06478114 ! pigment granule transport GO:0051904 12 6 0,000 0,01670227 0,06467208 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01670227 0,06456338 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01670227 0,06445506 ! catecholamine transport GO:0051937 7 6 0,000 0,01670227 0,06434709 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01670227 0,06423949 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01670227 0,06413224 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01670227 0,06402536 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01670227 0,06391883 ! protein prenylation GO:0018342 10 6 0,000 0,01670227 0,06381265 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01670227 0,06370682 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01670227 0,06360135 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01670227 0,06349622 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,01691142 0,06418525 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,01736382 0,06579372 ! response to hypoxia GO:0001666 132 72 1,000 0,01736382 0,0656855 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,01736382 0,06557764 ! tube morphogenesis GO:0035239 118 73 1,000 0,01782136 0,06719528 ! response to oxygen levels GO:0070482 137 74 1,000 0,01828399 0,06882682 ! response to nutrient GO:0007584 104 75 1,000 0,0187517 0,07047209 ! response to unfolded protein GO:0006986 99 76 1,000 0,01922445 0,0721309 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01945928 0,07289307 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01945928 0,07277455 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01945928 0,07265641 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01945928 0,07253865 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01945928 0,07242127 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01945928 0,07230428 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01945928 0,07218766 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01945928 0,07207141 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01945928 0,07195554 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01945928 0,07184004 ! reproductive behavior GO:0019098 12 7 0,000 0,01945928 0,07172492 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01945928 0,07161016 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,01945928 0,07149576 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01945928 0,07138173 ! oligopeptide transport GO:0006857 11 7 0,000 0,01945928 0,07126807 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01945928 0,07115477 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01945928 0,07104182 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,01945928 0,07092924 ! pericardium development GO:0060039 8 7 0,000 0,01945928 0,07081701 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01945928 0,07070513 ! fibril organization GO:0043206 13 7 0,000 0,01945928 0,07059361 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01945928 0,07048244 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01945928 0,07037162 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01945928 0,07026114 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01945928 0,07015102 ! lipoprotein transport GO:0042953 9 7 0,000 0,01945928 0,07004123 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01945928 0,06993179 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01945928 0,0698227 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01945928 0,06971394 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01945928 0,06960552 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01945928 0,06949743 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01945928 0,06938969 ! chemosensory behavior GO:0007635 9 7 0,000 0,01945928 0,06928227 ! microtubule bundle formation GO:0001578 8 7 0,000 0,01945928 0,06917519 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,01945928 0,06906844 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01945928 0,06896201 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01945928 0,06885592 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01945928 0,06875015 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01945928 0,06864471 ! reflex GO:0060004 12 7 0,000 0,01945928 0,06853958 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01945928 0,06843478 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01945928 0,0683303 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01945928 0,06822614 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01945928 0,06812229 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01945928 0,06801877 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01945928 0,06791555 ! spinal cord patterning GO:0021511 7 7 0,000 0,01945928 0,06781265 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01945928 0,06771006 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,01945928 0,06760778 ! adrenal gland development GO:0030325 17 7 0,000 0,01945928 0,0675058 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01945928 0,06740414 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01945928 0,06730278 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01945928 0,06720172 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01945928 0,06710097 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01945928 0,06700052 ! endosome organization GO:0007032 10 7 0,000 0,01945928 0,06690037 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01945928 0,06680052 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01945928 0,06670097 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01945928 0,06660171 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01945928 0,06650275 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01945928 0,06640408 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01945928 0,0663057 ! galactose metabolic process GO:0006012 10 7 0,000 0,01945928 0,06620761 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01945928 0,06610982 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01945928 0,06601231 ! organ growth GO:0035265 11 7 0,000 0,01945928 0,06591509 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,01945928 0,06581816 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,01945928 0,06572151 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01945928 0,06562514 ! retinol metabolic process GO:0042572 9 7 0,000 0,01945928 0,06552906 ! behavioral fear response GO:0001662 13 7 0,000 0,01945928 0,06543326 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,01945928 0,06533773 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01945928 0,06524249 ! rRNA modification GO:0000154 12 7 0,000 0,01945928 0,06514752 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01945928 0,06505283 ! response to UV-B GO:0010224 11 7 0,000 0,01945928 0,06495841 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01945928 0,06486427 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,01945928 0,0647704 ! intermediate filament organization GO:0045109 11 7 0,000 0,01945928 0,0646768 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01945928 0,06458347 ! fibrinolysis GO:0042730 9 7 0,000 0,01945928 0,06449041 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01945928 0,06439762 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01945928 0,0643051 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01945928 0,06421284 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01945928 0,06412084 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01945928 0,06402911 ! response to tropane GO:0014073 13 7 0,000 0,01945928 0,06393764 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01945928 0,06384643 ! melanosome localization GO:0032400 10 7 0,000 0,01945928 0,06375548 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01945928 0,06366479 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01945928 0,06357436 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,01945928 0,06348418 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01945928 0,06339426 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01945928 0,06330459 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01945928 0,06321518 ! mast cell activation GO:0045576 9 7 0,000 0,01945928 0,06312602 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01945928 0,06303711 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,01945928 0,06294845 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01945928 0,06286004 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01945928 0,06277188 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01945928 0,06268396 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01945928 0,06259629 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,01945928 0,06250887 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01945928 0,06242168 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01945928 0,06233475 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,01945928 0,06224805 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01945928 0,06216159 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01945928 0,06207538 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01945928 0,0619894 ! response to tumor cell GO:0002347 12 7 0,000 0,01945928 0,06190366 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01945928 0,06181816 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01945928 0,06173289 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01945928 0,06164786 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,01945928 0,06156306 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01945928 0,0614785 ! diuresis GO:0030146 12 7 0,000 0,01945928 0,06139417 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01945928 0,06131007 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01945928 0,06122619 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01945928 0,06114255 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01945928 0,06105914 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01945928 0,06097595 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01945928 0,06089299 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01945928 0,06081025 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01945928 0,06072774 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01945928 0,06064546 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01945928 0,06056339 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01945928 0,06048155 ! lymph node development GO:0048535 9 7 0,000 0,01945928 0,06039993 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01945928 0,06031853 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01945928 0,06023735 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01945928 0,06015638 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,01945928 0,06007563 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,01945928 0,0599951 ! ATP catabolic process GO:0006200 10 7 0,000 0,01945928 0,05991479 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01945928 0,05983469 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01945928 0,0597548 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,01945928 0,05967513 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01945928 0,05959567 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01945928 0,05951642 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01945928 0,05943738 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01945928 0,05935855 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01945928 0,05927993 ! retina homeostasis GO:0001895 9 7 0,000 0,01945928 0,05920152 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01945928 0,05912331 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,01945928 0,05904531 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01945928 0,05896752 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,01945928 0,05888993 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01945928 0,05881255 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01945928 0,05873536 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01945928 0,05865838 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,01970221 0,05931295 ! positive regulation of protein modification process GO:0031401 107 78 1,000 0,02018495 0,06068679 ! response to protein stimulus GO:0051789 111 81 1,000 0,02166274 0,06504479 ! vitamin metabolic process GO:0006766 103 81 1,000 0,02166274 0,06495998 ! ossification GO:0001503 134 82 1,000 0,02216509 0,06637984 GO:0060348|bone development, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02220872 0,06642401 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02220872 0,06633775 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,02220872 0,0662517 ! axon extension GO:0048675 11 8 0,000 0,02220872 0,06616589 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02220872 0,06608029 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02220872 0,06599491 ! associative learning GO:0008306 15 8 0,000 0,02220872 0,06590976 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02220872 0,06582482 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02220872 0,06574011 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,02220872 0,06565561 ! phosphate transport GO:0006817 10 8 0,000 0,02220872 0,06557133 ! N-glycan processing GO:0006491 12 8 0,000 0,02220872 0,06548726 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02220872 0,06540341 ! UTP metabolic process GO:0046051 8 8 0,000 0,02220872 0,06531977 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02220872 0,06523635 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02220872 0,06515314 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,02220872 0,06507014 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02220872 0,06498736 ! succinate metabolic process GO:0006105 14 8 0,000 0,02220872 0,06490478 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,02220872 0,06482242 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02220872 0,06474026 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02220872 0,06465831 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02220872 0,06457657 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,02220872 0,06449503 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02220872 0,0644137 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02220872 0,06433257 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02220872 0,06425165 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02220872 0,06417093 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02220872 0,06409042 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,02220872 0,0640101 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02220872 0,06392999 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02220872 0,06385008 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02220872 0,06377037 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02220872 0,06369085 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02220872 0,06361154 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,02220872 0,06353242 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02220872 0,0634535 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02220872 0,06337477 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02220872 0,06329624 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02220872 0,0632179 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02220872 0,06313976 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02220872 0,06306181 ! melanin metabolic process GO:0006582 12 8 0,000 0,02220872 0,06298405 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02220872 0,06290648 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02220872 0,06282911 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,02220872 0,06275192 ! macrophage activation GO:0042116 12 8 0,000 0,02220872 0,06267492 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02220872 0,06259812 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02220872 0,0625215 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02220872 0,06244507 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02220872 0,06236882 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02220872 0,06229276 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02220872 0,06221689 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02220872 0,0621412 ! ruffle organization GO:0031529 11 8 0,000 0,02220872 0,06206569 ! osteoblast development GO:0002076 13 8 0,000 0,02220872 0,06199037 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02220872 0,06191523 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02220872 0,06184027 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02220872 0,06176549 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02220872 0,0616909 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02220872 0,06161648 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02220872 0,06154225 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02220872 0,06146819 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02220872 0,06139431 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02220872 0,0613206 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02220872 0,06124708 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02220872 0,06117373 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02220872 0,06110055 ! segment specification GO:0007379 10 8 0,000 0,02220872 0,06102756 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02220872 0,06095473 ! cellular extravasation GO:0045123 11 8 0,000 0,02220872 0,06088208 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02220872 0,0608096 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02220872 0,06073729 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02220872 0,06066516 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,02220872 0,0605932 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02220872 0,0605214 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02220872 0,06044978 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,02220872 0,06037833 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02220872 0,06030704 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02220872 0,06023592 ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02220872 0,06016498 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02220872 0,06009419 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02220872 0,06002358 ! icosanoid secretion GO:0032309 12 8 0,000 0,02220872 0,05995313 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02220872 0,05988284 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02220872 0,05981272 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02220872 0,05974276 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02220872 0,05967297 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02220872 0,05960334 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02220872 0,05953387 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02220872 0,05946457 ! sterol catabolic process GO:0016127 9 8 0,000 0,02220872 0,05939542 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02220872 0,05932644 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02220872 0,05925761 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02220872 0,05918895 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02220872 0,05912044 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02220872 0,0590521 ! prophase GO:0051324 11 8 0,000 0,02220872 0,05898391 ! S phase GO:0051320 8 8 0,000 0,02220872 0,05891588 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02220872 0,058848 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02220872 0,05878028 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02220872 0,05871272 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02220872 0,05864531 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02220872 0,05857805 ! hormone catabolic process GO:0042447 13 8 0,000 0,02220872 0,05851096 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02220872 0,05844401 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02220872 0,05837722 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02220872 0,05831058 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02220872 0,05824409 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02220872 0,05817775 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02220872 0,05811156 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02220872 0,05804553 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02220872 0,05797964 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02220872 0,0579139 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02220872 0,05784832 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02220872 0,05778288 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02220872 0,05771759 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02220872 0,05765244 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02220872 0,05758745 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,02220872 0,05752259 ! sterol metabolic process GO:0016125 120 84 1,000 0,02318426 0,05998176 ! regulation of membrane potential GO:0042391 128 85 1,000 0,023701 0,06124978 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,023701 0,06118104 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,02422249 0,06245709 ! nucleosome organization GO:0034728 114 87 1,000 0,02474869 0,06374242 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02495061 0,06419061 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02495061 0,06411889 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02495061 0,06404733 ! CTP metabolic process GO:0046036 9 9 0,000 0,02495061 0,06397593 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02495061 0,06390469 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02495061 0,0638336 ! GTP metabolic process GO:0046039 9 9 0,000 0,02495061 0,06376268 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02495061 0,06369191 ! social behavior GO:0035176 14 9 0,000 0,02495061 0,0636213 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02495061 0,06355084 ! artery development GO:0060840 19 9 0,000 0,02495061 0,06348054 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02495061 0,0634104 ! response to pain GO:0048265 16 9 0,000 0,02495061 0,06334041 ! protein complex disassembly GO:0043241 17 9 0,000 0,02495061 0,06327057 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02495061 0,06320089 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02495061 0,06313136 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02495061 0,06306199 ! lung alveolus development GO:0048286 17 9 0,000 0,02495061 0,06299277 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02495061 0,06292369 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02495061 0,06285477 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02495061 0,06278601 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02495061 0,06271739 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02495061 0,06264892 ! protein targeting to ER GO:0045047 19 9 0,000 0,02495061 0,0625806 ! T cell selection GO:0045058 18 9 0,000 0,02495061 0,06251243 ! endoderm development GO:0007492 12 9 0,000 0,02495061 0,06244441 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02495061 0,06237653 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02495061 0,0623088 ! arginine catabolic process GO:0006527 10 9 0,000 0,02495061 0,06224122 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02495061 0,06217379 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02495061 0,0621065 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02495061 0,06203936 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02495061 0,06197236 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02495061 0,06190551 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02495061 0,0618388 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02495061 0,06177224 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02495061 0,06170582 ! mannose metabolic process GO:0006013 9 9 0,000 0,02495061 0,06163954 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02495061 0,0615734 ! receptor clustering GO:0043113 15 9 0,000 0,02495061 0,06150741 ! epithelial cell development GO:0002064 10 9 0,000 0,02495061 0,06144155 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02495061 0,06137584 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02495061 0,06131027 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02495061 0,06124483 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02495061 0,06117954 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02495061 0,06111439 ! motor axon guidance GO:0008045 14 9 0,000 0,02495061 0,06104937 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02495061 0,06098449 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02495061 0,06091975 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02495061 0,06085515 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02495061 0,06079069 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02495061 0,06072636 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02495061 0,06066217 ! DNA ligation GO:0006266 14 9 0,000 0,02495061 0,06059811 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02495061 0,06053419 ! response to amine stimulus GO:0014075 13 9 0,000 0,02495061 0,0604704 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02495061 0,06040675 ! erythrocyte development GO:0048821 11 9 0,000 0,02495061 0,06034323 ! renal water homeostasis GO:0003091 14 9 0,000 0,02495061 0,06027984 ! postreplication repair GO:0006301 11 9 0,000 0,02495061 0,06021659 ! mRNA cleavage GO:0006379 13 9 0,000 0,02495061 0,06015347 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02495061 0,06009048 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02495061 0,06002762 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02495061 0,0599649 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02495061 0,05990231 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02495061 0,05983984 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02495061 0,05977751 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02495061 0,05971531 ! acid secretion GO:0046717 14 9 0,000 0,02495061 0,05965323 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02495061 0,05959129 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02495061 0,05952947 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02495061 0,05946778 ! purine base metabolic process GO:0006144 18 9 0,000 0,02495061 0,05940622 ! oocyte differentiation GO:0009994 12 9 0,000 0,02495061 0,05934479 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02495061 0,05928348 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02495061 0,0592223 ! spleen development GO:0048536 15 9 0,000 0,02495061 0,05916125 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02495061 0,05910032 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02495061 0,05903952 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02495061 0,05897884 ! detection of calcium ion GO:0005513 13 9 0,000 0,02495061 0,05891828 ! blastocyst formation GO:0001825 12 9 0,000 0,02495061 0,05885786 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02495061 0,05879755 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02495061 0,05873737 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02495061 0,05867731 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02495061 0,05861737 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02495061 0,05855756 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02495061 0,05849787 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02495061 0,0584383 ! prepulse inhibition GO:0060134 14 9 0,000 0,02495061 0,05837885 ! embryonic placenta development GO:0001892 12 9 0,000 0,02495061 0,05831952 ! insulin secretion GO:0030073 17 9 0,000 0,02495061 0,05826031 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02495061 0,05820123 ! response to nicotine GO:0035094 16 9 0,000 0,02495061 0,05814226 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02495061 0,05808341 ! nucleus localization GO:0051647 15 9 0,000 0,02495061 0,05802468 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02495061 0,05796607 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,02527956 0,05867104 ! interphase GO:0051325 159 88 1,000 0,02527956 0,05861189 ! reproductive developmental process GO:0003006 127 89 1,000 0,02581509 0,05979326 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,02744929 0,06351446 ! cell fate commitment GO:0045165 141 92 1,000 0,02744929 0,06345063 ! DNA recombination GO:0006310 146 92 1,000 0,02744929 0,06338692 ! sulfur metabolic process GO:0006790 118 92 1,000 0,02744929 0,06332334 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02768497 0,06380304 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02768497 0,06373917 ! neuron fate specification GO:0048665 11 10 0,000 0,02768497 0,06367543 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02768497 0,06361182 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02768497 0,06354833 ! thyroid gland development GO:0030878 19 10 0,000 0,02768497 0,06348498 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,02768497 0,06342174 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02768497 0,06335864 ! synapsis GO:0007129 13 10 0,000 0,02768497 0,06329566 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02768497 0,0632328 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02768497 0,06317007 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02768497 0,06310746 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02768497 0,06304498 ! sulfate transport GO:0008272 12 10 0,000 0,02768497 0,06298262 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02768497 0,06292039 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02768497 0,06285827 ! androgen metabolic process GO:0008209 13 10 0,000 0,02768497 0,06279628 ! phospholipid efflux GO:0033700 16 10 0,000 0,02768497 0,06273441 ! hippocampus development GO:0021766 19 10 0,000 0,02768497 0,06267267 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,02768497 0,06261104 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02768497 0,06254954 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02768497 0,06248816 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02768497 0,06242689 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02768497 0,06236575 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02768497 0,06230473 ! pathogenesis GO:0009405 13 10 0,000 0,02768497 0,06224382 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02768497 0,06218304 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02768497 0,06212237 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02768497 0,06206182 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02768497 0,06200139 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02768497 0,06194108 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02768497 0,06188088 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02768497 0,06182081 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02768497 0,06176084 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02768497 0,061701 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02768497 0,06164127 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02768497 0,06158165 ! response to X-ray GO:0010165 16 10 0,000 0,02768497 0,06152215 ! B cell proliferation GO:0042100 14 10 0,000 0,02768497 0,06146277 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02768497 0,0614035 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02768497 0,06134435 ! forebrain cell migration GO:0021885 17 10 0,000 0,02768497 0,0612853 ! lipid digestion GO:0044241 15 10 0,000 0,02768497 0,06122638 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02768497 0,06116756 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02768497 0,06110886 ! UV protection GO:0009650 14 10 0,000 0,02768497 0,06105027 ! entry into host cell GO:0030260 20 10 0,000 0,02768497 0,06099179 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02768497 0,06093343 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02768497 0,06087517 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02768497 0,06081703 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02768497 0,060759 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02768497 0,06070108 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02768497 0,06064327 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02768497 0,06058557 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02768497 0,06052798 ! regulation of organ growth GO:0046620 11 10 0,000 0,02768497 0,06047049 ! response to dsRNA GO:0043331 18 10 0,000 0,02768497 0,06041312 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02768497 0,06035586 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02768497 0,0602987 ! embryonic axis specification GO:0000578 12 10 0,000 0,02768497 0,06024166 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02768497 0,06018472 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02768497 0,06012788 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02768497 0,06007116 ! cranial nerve development GO:0021545 12 10 0,000 0,02768497 0,06001454 ! fucose catabolic process GO:0019317 16 10 0,000 0,02768497 0,05995803 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02768497 0,05990163 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02768497 0,05984533 ! protein sumoylation GO:0016925 12 10 0,000 0,02768497 0,05978914 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02768497 0,05973305 ! zymogen activation GO:0031638 14 10 0,000 0,02768497 0,05967707 ! salivary gland development GO:0007431 22 10 0,000 0,02768497 0,05962119 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02768497 0,05956542 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02768497 0,05950975 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02768497 0,05945418 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02768497 0,05939872 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02768497 0,05934336 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02768497 0,05928811 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02768497 0,05923296 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02768497 0,05917791 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02768497 0,05912296 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02768497 0,05906812 ! detection of bacterium GO:0016045 10 10 0,000 0,02768497 0,05901337 ! embryonic gut development GO:0048566 11 10 0,000 0,02768497 0,05895873 ! activation of innate immune response GO:0002218 10 10 0,000 0,02768497 0,05890419 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02768497 0,05884975 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02768497 0,05879541 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02768497 0,05874117 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02768497 0,05868703 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,02768497 0,05863299 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,02800313 0,05925226 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,02800313 0,0591978 ! angiogenesis GO:0001525 149 95 1,000 0,02912431 0,0615114 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,02969159 0,06265198 ! response to light stimulus GO:0009416 153 96 1,000 0,02969159 0,06259455 ! rRNA transcription GO:0009303 17 11 0,000 0,03041181 0,06405419 ! respiratory burst GO:0045730 14 11 0,000 0,03041181 0,06399558 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,03041181 0,06393709 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,03041181 0,0638787 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,03041181 0,06382041 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,03041181 0,06376224 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,03041181 0,06370417 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,03041181 0,0636462 ! RNA polyadenylation GO:0043631 19 11 0,000 0,03041181 0,06358834 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,03041181 0,06353058 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,03041181 0,06347293 ! mating GO:0007618 14 11 0,000 0,03041181 0,06341539 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,03041181 0,06335795 ! T cell proliferation GO:0042098 20 11 0,000 0,03041181 0,06330061 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,03041181 0,06324338 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,03041181 0,06318625 ! bone resorption GO:0045453 16 11 0,000 0,03041181 0,06312922 ! regulated secretory pathway GO:0045055 14 11 0,000 0,03041181 0,06307229 ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,03041181 0,06301547 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,03041181 0,06295875 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,03041181 0,06290213 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,03041181 0,06284562 ! syncytium formation GO:0006949 15 11 0,000 0,03041181 0,0627892 ! plasma membrane organization GO:0007009 18 11 0,000 0,03041181 0,06273289 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,03041181 0,06267668 ! focal adhesion formation GO:0048041 24 11 0,000 0,03041181 0,06262057 ! mitotic spindle organization GO:0007052 15 11 0,000 0,03041181 0,06256456 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,03041181 0,06250864 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,03041181 0,06245283 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,03041181 0,06239712 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,03041181 0,06234151 ! adult heart development GO:0007512 11 11 0,000 0,03041181 0,062286 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,03041181 0,06223058 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,03041181 0,06217527 ! temperature homeostasis GO:0001659 16 11 0,000 0,03041181 0,06212005 ! L-glutamate transport GO:0015813 16 11 0,000 0,03041181 0,06206493 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,03041181 0,06200991 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,03041181 0,06195498 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,03041181 0,06190015 ! protein homotetramerization GO:0051289 18 11 0,000 0,03041181 0,06184542 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,03041181 0,06179079 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,03041181 0,06173625 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,03041181 0,06168181 ! vasoconstriction GO:0042310 15 11 0,000 0,03041181 0,06162747 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,03041181 0,06157322 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,03041181 0,06151906 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,03041181 0,061465 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,03041181 0,06141104 ! ribosome assembly GO:0042255 13 11 0,000 0,03041181 0,06135717 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,03041181 0,0613034 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,03041181 0,06124971 ! chromatin silencing GO:0006342 19 11 0,000 0,03041181 0,06119613 ! nucleosome positioning GO:0016584 13 11 0,000 0,03041181 0,06114263 ! T cell homeostasis GO:0043029 20 11 0,000 0,03041181 0,06108923 ! regulation of isotype switching GO:0045191 19 11 0,000 0,03041181 0,06103593 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,03041181 0,06098271 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,03041181 0,06092959 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,03041181 0,06087657 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,03041181 0,06082363 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,03041181 0,06077079 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,03041181 0,06071803 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,03041181 0,06066537 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,03041181 0,0606128 ! male genitalia development GO:0030539 13 11 0,000 0,03041181 0,06056032 ! cholesterol efflux GO:0033344 19 11 0,000 0,03041181 0,06050794 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,03041181 0,06045564 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,03041181 0,06040343 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,03041181 0,06035131 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,03041181 0,06029929 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,03041181 0,06024735 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,03041181 0,0601955 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,03041181 0,06014374 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,03041181 0,06009207 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,03041181 0,06004049 ! actin filament polymerization GO:0030041 17 11 0,000 0,03041181 0,059989 ! acrosome reaction GO:0007340 13 11 0,000 0,03041181 0,0599376 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,03041181 0,05988628 ! calcium ion transport GO:0006816 167 99 1,000 0,03141984 0,06181833 ! divalent metal ion transport GO:0070838 171 100 1,000 0,03200464 0,0629151 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,03200464 0,06286137 ! lactation GO:0007595 20 12 0,000 0,03313117 0,0650185 ! reproductive cellular process GO:0048610 14 12 0,000 0,03313117 0,06496307 ! tRNA modification GO:0006400 14 12 0,000 0,03313117 0,06490774 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,03313117 0,0648525 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,03313117 0,06479735 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,03313117 0,0647423 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,03313117 0,06468734 ! non-recombinational repair GO:0000726 19 12 0,000 0,03313117 0,06463247 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,03313117 0,0645777 ! peroxisomal transport GO:0043574 21 12 0,000 0,03313117 0,06452302 ! cartilage condensation GO:0001502 18 12 0,000 0,03313117 0,06446843 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,03313117 0,06441394 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,03313117 0,06435953 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,03313117 0,06430522 ! heart looping GO:0001947 15 12 0,000 0,03313117 0,064251 ! palate development GO:0060021 15 12 0,000 0,03313117 0,06419687 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,03313117 0,06414283 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,03313117 0,06408889 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,03313117 0,06403503 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,03313117 0,06398126 ! arginine metabolic process GO:0006525 13 12 0,000 0,03313117 0,06392759 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,03313117 0,063874 ! methionine metabolic process GO:0006555 13 12 0,000 0,03313117 0,06382051 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,03313117 0,0637671 ! Golgi organization GO:0007030 18 12 0,000 0,03313117 0,06371378 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,03313117 0,06366056 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,03313117 0,06360742 ! monoamine transport GO:0015844 13 12 0,000 0,03313117 0,06355437 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03313117 0,06350141 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,03313117 0,06344853 ! L-amino acid transport GO:0015807 20 12 0,000 0,03313117 0,06339575 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,03313117 0,06334305 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,03313117 0,06329044 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,03313117 0,06323791 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,03313117 0,06318548 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,03313117 0,06313313 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,03313117 0,06308087 ! cerebellum development GO:0021549 13 12 0,000 0,03313117 0,06302869 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,03313117 0,0629766 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,03313117 0,0629246 ! histone acetylation GO:0016573 23 12 0,000 0,03313117 0,06287268 ! histone methylation GO:0016571 15 12 0,000 0,03313117 0,06282085 ! autonomic nervous system development GO:0048483 23 12 0,000 0,03313117 0,0627691 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,03313117 0,06271744 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,03313117 0,06266586 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,03313117 0,06261437 ! response to gamma radiation GO:0010332 20 12 0,000 0,03313117 0,06256296 ! regulation of epidermis development GO:0045682 17 12 0,000 0,03313117 0,06251164 ! intestinal absorption GO:0050892 19 12 0,000 0,03313117 0,0624604 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,03313117 0,06240924 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,03313117 0,06235817 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,03313117 0,06230718 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,03313117 0,06225628 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,03313117 0,06220546 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,03313117 0,06215472 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,03313117 0,06210406 ! microspike assembly GO:0030035 23 12 0,000 0,03313117 0,06205349 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,03313117 0,062003 ! response to cold GO:0009409 14 12 0,000 0,03313117 0,06195259 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,03584305 0,06696914 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,03584305 0,06691478 ! cGMP metabolic process GO:0046068 16 13 0,000 0,03584305 0,06686051 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,03584305 0,06680633 ! water transport GO:0006833 17 13 0,000 0,03584305 0,06675224 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,03584305 0,06669823 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,03584305 0,06664431 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,03584305 0,06659048 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,03584305 0,06653673 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,03584305 0,06648308 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,03584305 0,0664295 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,03584305 0,06637602 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,03584305 0,06632262 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,03584305 0,0662693 ! response to hexose stimulus GO:0009746 19 13 0,000 0,03584305 0,06621608 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,03584305 0,06616293 ! glutamate metabolic process GO:0006536 18 13 0,000 0,03584305 0,06610987 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,03584305 0,0660569 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,03584305 0,06600401 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,03584305 0,06595121 ! NAD metabolic process GO:0019674 21 13 0,000 0,03584305 0,06589849 ! exocrine system development GO:0035272 27 13 0,000 0,03584305 0,06584586 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,03584305 0,06579331 ! bone mineralization GO:0030282 15 13 0,000 0,03584305 0,06574084 ! regulation of exocytosis GO:0017157 17 13 0,000 0,03584305 0,06568846 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,03584305 0,06563616 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,03584305 0,06558394 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,03584305 0,06553181 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,03584305 0,06547976 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,03584305 0,06542779 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,03584305 0,0653759 ! genitalia development GO:0048806 15 13 0,000 0,03584305 0,0653241 ! regulation of cellular pH GO:0030641 20 13 0,000 0,03584305 0,06527238 ! cellular pigmentation GO:0033059 24 13 0,000 0,03584305 0,06522074 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,03584305 0,06516918 ! cofactor transport GO:0051181 19 13 0,000 0,03584305 0,0651177 ! NADP metabolic process GO:0006739 18 13 0,000 0,03584305 0,06506631 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,03584305 0,065015 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,03584305 0,06496376 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03584305 0,06491261 ! gas transport GO:0015669 18 13 0,000 0,03584305 0,06486154 ! regulation of RNA stability GO:0043487 28 13 0,000 0,03584305 0,06481055 ! heme biosynthetic process GO:0006783 20 13 0,000 0,03584305 0,06475963 ! regulation of axon extension GO:0030516 23 13 0,000 0,03584305 0,0647088 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,03584305 0,06465805 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,03584305 0,06460738 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,03584305 0,06455678 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,03584305 0,06450627 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,03584305 0,06445584 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,03584305 0,06440548 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,03854748 0,06921093 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,03854748 0,06915694 ! superoxide anion generation GO:0042554 18 14 0,000 0,03854748 0,06910304 ! neuron maturation GO:0042551 21 14 0,000 0,03854748 0,06904922 ! regulation of S phase GO:0033261 18 14 0,000 0,03854748 0,06899549 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,03854748 0,06894184 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,03854748 0,06888827 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,03854748 0,06883479 ! inositol metabolic process GO:0006020 20 14 0,000 0,03854748 0,06878138 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,03854748 0,06872806 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,03854748 0,06867483 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,03854748 0,06862167 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,03854748 0,0685686 ! gene silencing by RNA GO:0031047 20 14 0,000 0,03854748 0,06851561 ! response to cAMP GO:0051591 19 14 0,000 0,03854748 0,06846271 ! limbic system development GO:0021761 25 14 0,000 0,03854748 0,06840988 ! startle response GO:0001964 21 14 0,000 0,03854748 0,06835713 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,03854748 0,06830447 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,03854748 0,06825189 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,03854748 0,06819939 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,03854748 0,06814697 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,03854748 0,06809463 ! glycine metabolic process GO:0006544 22 14 0,000 0,03854748 0,06804237 ! pituitary gland development GO:0021983 23 14 0,000 0,03854748 0,06799019 ! cellular response to starvation GO:0009267 21 14 0,000 0,03854748 0,06793809 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,03854748 0,06788607 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,03854748 0,06783413 ! regulation of heart rate GO:0002027 23 14 0,000 0,03854748 0,06778227 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,03854748 0,06773048 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,03854748 0,06767878 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,03854748 0,06762716 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,03854748 0,06757561 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,03854748 0,06752415 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,03854748 0,06747276 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,03854748 0,06742145 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,03854748 0,06737022 ! axon cargo transport GO:0008088 27 14 0,000 0,03854748 0,06731906 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,03854748 0,06726798 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,03854748 0,06721699 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,03854748 0,06716606 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03854748 0,06711522 ! mRNA splice site selection GO:0006376 26 14 0,000 0,03854748 0,06706445 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,03854748 0,06701376 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,03854748 0,06696314 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,03854748 0,06691261 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,03854748 0,06686214 GO:0046466|membrane lipid catabolic process, ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,03854748 0,06681176 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,03854748 0,06676145 ! muscle maintenance GO:0046716 19 14 0,000 0,03854748 0,06671121 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,03854748 0,06666106 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,03854748 0,06661097 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,03854748 0,06656096 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,03854748 0,06651103 ! cell killing GO:0001906 20 14 0,000 0,03854748 0,06646117 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,03854748 0,06641139 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,03854748 0,06636168 ! cilium assembly GO:0042384 20 14 0,000 0,03854748 0,06631204 ! peptide hormone secretion GO:0030072 23 14 0,000 0,03854748 0,06626248 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,04124448 0,07084563 ! positive regulation of cell size GO:0045793 20 15 0,000 0,04124448 0,07079276 ! metencephalon development GO:0022037 19 15 0,000 0,04124448 0,07073997 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,04124448 0,07068726 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,04124448 0,07063462 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,04124448 0,07058207 ! skin development GO:0043588 25 15 0,000 0,04124448 0,07052959 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,04124448 0,07047719 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,04124448 0,07042487 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,04124448 0,07037263 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,04124448 0,07032046 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,04124448 0,07026837 ! bile acid metabolic process GO:0008206 22 15 0,000 0,04124448 0,07021636 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,04124448 0,07016442 ! adult walking behavior GO:0007628 25 15 0,000 0,04124448 0,07011257 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,04124448 0,07006078 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,04124448 0,07000908 ! centrosome cycle GO:0007098 16 15 0,000 0,04124448 0,06995745 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,04124448 0,0699059 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,04124448 0,06985442 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,04124448 0,06980302 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,04124448 0,06975169 ! cerebral cortex development GO:0021987 29 15 0,000 0,04124448 0,06970044 ! response to osmotic stress GO:0006970 22 15 0,000 0,04124448 0,06964927 ! vesicle coating GO:0006901 25 15 0,000 0,04124448 0,06959817 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,04124448 0,06954714 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,04124448 0,06949619 ! peptide secretion GO:0002790 27 15 0,000 0,04124448 0,06944532 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,04124448 0,06939451 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,04124448 0,06934379 ! neuron recognition GO:0008038 22 15 0,000 0,04124448 0,06929313 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,04124448 0,06924256 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,04124448 0,06919205 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,04124448 0,06914162 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,04124448 0,06909126 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,04124448 0,06904098 ! biomineral formation GO:0031214 18 15 0,000 0,04124448 0,06899076 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,04124448 0,06894063 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,04124448 0,06889056 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,04124448 0,06884057 ! dopamine metabolic process GO:0042417 30 15 0,000 0,04124448 0,06879065 ! organic cation transport GO:0015695 19 15 0,000 0,04124448 0,0687408 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,04124448 0,06869102 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,04124448 0,06864132 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,04124448 0,06859169 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,04124448 0,06854212 ! defense response to virus GO:0051607 27 15 0,000 0,04124448 0,06849264 ! peptide hormone processing GO:0016486 19 15 0,000 0,04124448 0,06844322 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,04124448 0,06839387 ! protein secretion GO:0009306 27 16 0,000 0,04393407 0,07280141 ! hormone secretion GO:0046879 25 16 0,000 0,04393407 0,07274899 ! bone remodeling GO:0046849 24 16 0,000 0,04393407 0,07269666 ! endothelial cell migration GO:0043542 22 16 0,000 0,04393407 0,07264439 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,04393407 0,07259221 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,04393407 0,07254009 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,04393407 0,07248806 ! glial cell development GO:0021782 24 16 0,000 0,04393407 0,07243609 ! patterning of blood vessels GO:0001569 24 16 0,000 0,04393407 0,07238421 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,04393407 0,07233239 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,04393407 0,07228065 ! protein polyubiquitination GO:0000209 26 16 0,000 0,04393407 0,07222899 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,04393407 0,07217739 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,04393407 0,07212588 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,04393407 0,07207443 ! fructose metabolic process GO:0006000 20 16 0,000 0,04393407 0,07202306 ! regulation of protein binding GO:0043393 27 16 0,000 0,04393407 0,07197176 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,04393407 0,07192053 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,04393407 0,07186938 ! protein export from nucleus GO:0006611 24 16 0,000 0,04393407 0,0718183 ! negative regulation of immune response GO:0050777 28 16 0,000 0,04393407 0,07176729 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,04393407 0,07171636 ! DNA replication initiation GO:0006270 25 16 0,000 0,04393407 0,0716655 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,04393407 0,07161471 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,04393407 0,07156399 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,04393407 0,07151334 ! diencephalon development GO:0021536 25 16 0,000 0,04393407 0,07146277 ! oogenesis GO:0048477 23 16 0,000 0,04393407 0,07141226 ! neural crest cell migration GO:0001755 24 16 0,000 0,04393407 0,07136183 ! G1 phase GO:0051318 27 16 0,000 0,04393407 0,07131147 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,04393407 0,07126118 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,04393407 0,07121096 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,04393407 0,07116081 ! steroid catabolic process GO:0006706 22 16 0,000 0,04393407 0,07111073 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,04393407 0,07106073 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,04393407 0,07101079 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,04393407 0,07096092 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,04393407 0,07091112 ! sperm-egg recognition GO:0035036 16 16 0,000 0,04393407 0,0708614 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,04393407 0,07081174 ! nerve development GO:0021675 18 16 0,000 0,04393407 0,07076215 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,04393407 0,07071263 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,04393407 0,07066318 ! negative regulation of translation GO:0017148 22 16 0,000 0,04393407 0,0706138 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,04661626 0,07487249 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,04661626 0,07482024 ! negative regulation of defense response GO:0031348 19 17 0,000 0,04661626 0,07476806 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,04661626 0,07471596 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,04661626 0,07466393 ! glycerol metabolic process GO:0006071 20 17 0,000 0,04661626 0,07461197 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,04661626 0,07456008 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,04661626 0,07450827 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,04661626 0,07445653 ! signal complex assembly GO:0007172 29 17 0,000 0,04661626 0,07440486 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,04661626 0,07435326 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,04661626 0,07430173 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,04661626 0,07425028 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,04661626 0,07419889 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,04661626 0,07414758 ! memory GO:0007613 25 17 0,000 0,04661626 0,07409634 ! keratinization GO:0031424 17 17 0,000 0,04661626 0,07404517 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,04661626 0,07399407 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,04661626 0,07394304 ! retinoid metabolic process GO:0001523 22 17 0,000 0,04661626 0,07389208 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,04661626 0,07384119 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,04661626 0,07379037 ! vacuolar transport GO:0007034 24 17 0,000 0,04661626 0,07373962 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,04661626 0,07368894 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,04661626 0,07363833 ! membrane budding GO:0006900 29 17 0,000 0,04661626 0,07358778 ! heme metabolic process GO:0042168 27 17 0,000 0,04661626 0,07353731 ! actin filament bundle formation GO:0051017 26 17 0,000 0,04661626 0,07348691 ! neuromuscular junction development GO:0007528 23 17 0,000 0,04661626 0,07343658 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,04661626 0,07338631 ! body fluid secretion GO:0007589 27 17 0,000 0,04661626 0,07333612 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,04661626 0,07328599 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,04661626 0,07323593 ! sensory perception of pain GO:0019233 23 17 0,000 0,04661626 0,07318594 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,04661626 0,07313602 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,04661626 0,07308616 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,04661626 0,07303638 ! synaptogenesis GO:0007416 24 17 0,000 0,04661626 0,07298666 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,04661626 0,07293701 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,04661626 0,07288742 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,04661626 0,07283791 ! cell-cell junction organization GO:0045216 25 17 0,000 0,04661626 0,07278846 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,04661626 0,07273908 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,04661626 0,07268976 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,04661626 0,07264052 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,04661626 0,07259133 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,04661626 0,07254222 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,04661626 0,07249317 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,04929109 0,07660101 ! positive regulation of translation GO:0045727 28 18 0,000 0,04929109 0,07654929 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,04929109 0,07649764 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,04929109 0,07644605 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,04929109 0,07639454 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,04929109 0,0763431 ! cAMP metabolic process GO:0046058 33 18 0,000 0,04929109 0,07629172 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,04929109 0,07624041 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,04929109 0,07618918 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,04929109 0,07613801 ! axis specification GO:0009798 26 18 0,000 0,04929109 0,07608691 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,04929109 0,07603588 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,04929109 0,07598492 ! pancreas development GO:0031016 26 18 0,000 0,04929109 0,07593402 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,04929109 0,0758832 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,04929109 0,07583244 ! glutamine metabolic process GO:0006541 23 18 0,000 0,04929109 0,07578175 ! pigmentation during development GO:0048066 31 18 0,000 0,04929109 0,07573113 ! central nervous system neuron development GO:0021954 30 18 0,000 0,04929109 0,07568057 ! fucose metabolic process GO:0006004 26 18 0,000 0,04929109 0,07563008 ! response to fungus GO:0009620 19 18 0,000 0,04929109 0,07557966 ! peptide cross-linking GO:0018149 31 18 0,000 0,04929109 0,07552931 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,04929109 0,07547903 ! heart process GO:0003015 27 18 0,000 0,04929109 0,07542881 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,04929109 0,07537865 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,04929109 0,07532857 ! visual learning GO:0008542 35 18 0,000 0,04929109 0,07527855 ! somitogenesis GO:0001756 24 18 0,000 0,04929109 0,0752286 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,04929109 0,07517871 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,04929109 0,07512889 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,04929109 0,07507914 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,04929109 0,07502945 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,04929109 0,07497983 ! vitamin transport GO:0051180 24 18 0,000 0,04929109 0,07493027 ! hormone transport GO:0009914 27 18 0,000 0,04929109 0,07488078 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,04929109 0,07483135 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,04929109 0,07478199 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,04929109 0,07473269 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,04929109 0,07468346 ! cell-cell recognition GO:0009988 20 18 0,000 0,04929109 0,0746343 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,04929109 0,0745852 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,04929109 0,07453616 ! regulation of glucose import GO:0046324 21 18 0,000 0,04929109 0,07448719 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,04929109 0,07443828 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,04929109 0,07438943 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,04929109 0,07434065 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,04929109 0,07429194 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,05195856 0,07826109 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,05195856 0,07820987 ! positive regulation of ossification GO:0045778 30 19 0,000 0,05195856 0,07815872 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,05195856 0,07810764 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,05195856 0,07805662 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,05195856 0,07800567 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,05195856 0,07795478 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,05195856 0,07790397 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,05195856 0,07785321 ! response to alkaloid GO:0043279 32 19 0,000 0,05195856 0,07780253 ! sensory perception of taste GO:0050909 23 19 0,000 0,05195856 0,07775191 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,05195856 0,07770135 ! smooth muscle contraction GO:0006939 36 19 0,000 0,05195856 0,07765087 ! peroxisome organization GO:0007031 29 19 0,000 0,05195856 0,07760044 ! digestive system process GO:0022600 30 19 0,000 0,05195856 0,07755009 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,05195856 0,07749979 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,05195856 0,07744957 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,05195856 0,07739941 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,05195856 0,07734931 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,05195856 0,07729928 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,05195856 0,07724931 ! response to starvation GO:0042594 30 19 0,000 0,05195856 0,07719941 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,05195856 0,07714957 ! plasma membrane fusion GO:0045026 23 19 0,000 0,05195856 0,0770998 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,05195856 0,07705009 ! cytolysis GO:0019835 20 19 0,000 0,05195856 0,07700044 ! renal system process GO:0003014 35 19 0,000 0,05195856 0,07695086 ! vasodilation GO:0042311 33 19 0,000 0,05195856 0,07690134 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,05195856 0,07685189 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,05195856 0,0768025 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,05195856 0,07675317 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,05195856 0,0767039 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,05195856 0,0766547 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,05195856 0,07660557 ! sarcomere organization GO:0045214 23 19 0,000 0,05195856 0,07655649 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,05195856 0,07650748 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,05195856 0,07645853 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,05195856 0,07640964 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,05195856 0,07636082 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,05195856 0,07631206 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,05195856 0,07626336 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,05195856 0,07621472 ! protein stabilization GO:0050821 26 19 0,000 0,05195856 0,07616615 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,0546187 0,08001465 ! iron ion transport GO:0006826 37 20 0,000 0,0546187 0,07996372 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,0546187 0,07991285 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,0546187 0,07986205 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,0546187 0,07981131 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,0546187 0,07976064 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,0546187 0,07971003 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,0546187 0,07965948 ! spinal cord development GO:0021510 31 20 0,000 0,0546187 0,079609 ! response to ethanol GO:0045471 37 20 0,000 0,0546187 0,07955859 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,0546187 0,07950823 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,0546187 0,07945794 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,0546187 0,07940772 ! chromosome condensation GO:0030261 31 20 0,000 0,0546187 0,07935755 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,0546187 0,07930745 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,0546187 0,07925742 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,0546187 0,07920744 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,0546187 0,07915753 ! pallium development GO:0021543 38 20 0,000 0,0546187 0,07910769 ! DNA modification GO:0006304 28 20 0,000 0,0546187 0,0790579 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,0546187 0,07900818 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,0546187 0,07895852 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,0546187 0,07890892 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,0546187 0,07885939 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,0546187 0,07880992 ! collagen catabolic process GO:0030574 25 20 0,000 0,0546187 0,07876051 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,0546187 0,07871116 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,0546187 0,07866187 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,0546187 0,07861264 ! alditol metabolic process GO:0019400 24 20 0,000 0,0546187 0,07856348 ! actin filament-based movement GO:0030048 34 20 0,000 0,0546187 0,07851438 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,05727153 0,0822764 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,05727153 0,08222504 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,05727153 0,08217374 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,05727153 0,08212251 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,05727153 0,08207135 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,05727153 0,08202024 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,05727153 0,0819692 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,05727153 0,08191823 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,05727153 0,08186732 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,05727153 0,08181647 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,05727153 0,08176568 ! protein amino acid acylation GO:0043543 37 21 0,000 0,05727153 0,08171496 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,05727153 0,0816643 ! phototransduction GO:0007602 25 21 0,000 0,05727153 0,0816137 ! dendrite development GO:0016358 35 21 0,000 0,05727153 0,08156316 ! visual behavior GO:0007632 39 21 0,000 0,05727153 0,08151269 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,05727153 0,08146228 ! ovarian follicle development GO:0001541 30 21 0,000 0,05727153 0,08141193 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,05727153 0,08136165 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,05727153 0,08131143 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,05727153 0,08126127 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,05727153 0,08121117 ! cell aging GO:0007569 32 21 0,000 0,05727153 0,08116113 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,05727153 0,08111115 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,05727153 0,08106124 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,05727153 0,08101138 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,05727153 0,08096159 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,05727153 0,08091186 ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,05727153 0,08086219 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,05727153 0,08081258 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,05727153 0,08076304 ! fatty acid transport GO:0015908 30 21 0,000 0,05727153 0,08071355 ! immunoglobulin production GO:0002377 33 21 0,000 0,05727153 0,08066412 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,05727153 0,08061476 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,05727153 0,08056545 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,05727153 0,0805162 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,05727153 0,08046702 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,05727153 0,08041789 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,05727153 0,08036883 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,05727153 0,08031982 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,05727153 0,08027088 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,05727153 0,08022199 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,05727153 0,08017317 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,05727153 0,0801244 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,05727153 0,08007569 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,05727153 0,08002704 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,05727153 0,07997845 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,05727153 0,07992992 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,05991706 0,0835714 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,05991706 0,08352075 ! viral genome replication GO:0019079 29 22 0,000 0,05991706 0,08347016 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,05991706 0,08341964 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,05991706 0,08336917 ! leukocyte adhesion GO:0007159 38 22 0,000 0,05991706 0,08331877 ! molting cycle process GO:0022404 40 22 0,000 0,05991706 0,08326842 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,05991706 0,08321814 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,05991706 0,08316792 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,05991706 0,08311776 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,05991706 0,08306766 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,05991706 0,08301762 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,05991706 0,08296764 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,05991706 0,08291771 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,05991706 0,08286785 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,05991706 0,08281805 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,05991706 0,08276831 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,05991706 0,08271863 ! regulation of behavior GO:0050795 38 22 0,000 0,05991706 0,08266901 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,05991706 0,08261945 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,05991706 0,08256995 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,05991706 0,0825205 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,05991706 0,08247112 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,05991706 0,0824218 ! blastocyst development GO:0001824 37 22 0,000 0,05991706 0,08237253 ! neural tube closure GO:0001843 33 22 0,000 0,05991706 0,08232332 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,05991706 0,08227417 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,06255532 0,08584561 ! neuron fate commitment GO:0048663 32 23 0,000 0,06255532 0,08579442 ! embryonic pattern specification GO:0009880 31 23 0,000 0,06255532 0,08574329 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,06255532 0,08569223 ! myelination GO:0042552 35 23 0,000 0,06255532 0,08564122 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,06255532 0,08559027 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,06255532 0,08553939 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,06255532 0,08548856 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,06255532 0,08543779 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,06255532 0,08538709 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,06255532 0,08533644 ! vesicle targeting GO:0006903 32 23 0,000 0,06255532 0,08528586 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,06255532 0,08523534 ! osteoblast differentiation GO:0001649 40 23 0,000 0,06255532 0,08518487 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,06255532 0,08513447 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,06255532 0,08508412 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,06255532 0,08503383 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,06255532 0,08498361 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,06255532 0,08493344 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,06255532 0,08488333 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,06255532 0,08483328 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,06255532 0,08478329 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,06255532 0,08473336 ! cell fate determination GO:0001709 45 23 0,000 0,06255532 0,08468349 ! pentose metabolic process GO:0019321 31 23 0,000 0,06255532 0,08463367 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,06255532 0,08458392 ! spermatid development GO:0007286 33 23 0,000 0,06255532 0,08453422 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,06255532 0,08448458 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,06255532 0,084435 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,06255532 0,08438548 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,06255532 0,08433602 ! telomere organization GO:0032200 32 23 0,000 0,06255532 0,08428661 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,06255532 0,08423726 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,06255532 0,08418797 ! regulation of amine transport GO:0051952 38 23 0,000 0,06255532 0,08413874 ! liver development GO:0001889 40 23 0,000 0,06255532 0,08408957 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,06518633 0,0875751 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,06518633 0,08752397 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,06518633 0,08747291 ! superoxide metabolic process GO:0006801 32 24 0,000 0,06518633 0,08742191 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,06518633 0,08737096 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,06518633 0,08732007 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,06518633 0,08726925 ! sperm motility GO:0030317 27 24 0,000 0,06518633 0,08721848 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,06518633 0,08716777 ! vacuole organization GO:0007033 39 24 0,000 0,06518633 0,08711712 ! receptor metabolic process GO:0043112 37 24 0,000 0,06518633 0,08706653 ! neural crest cell development GO:0014032 39 24 0,000 0,06518633 0,087016 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,06518633 0,08696553 ! primary neural tube formation GO:0014020 35 24 0,000 0,06518633 0,08691511 ! negative regulation of cell development GO:0010721 56 24 0,000 0,06518633 0,08686476 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,06518633 0,08681446 ! base-excision repair GO:0006284 31 24 0,000 0,06518633 0,08676422 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,06518633 0,08671404 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,06518633 0,08666391 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,06518633 0,08661385 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,06518633 0,08656384 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,06518633 0,08651389 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,06781011 0,0899442 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,06781011 0,08989236 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,06781011 0,08984058 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,06781011 0,08978886 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,06781011 0,0897372 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,06781011 0,0896856 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,06781011 0,08963405 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 43 25 0,000 0,06781011 0,08958257 ! male gonad development GO:0008584 33 25 0,000 0,06781011 0,08953114 ! iron ion homeostasis GO:0055072 39 25 0,000 0,06781011 0,08947978 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,06781011 0,08942847 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,06781011 0,08937722 ! phospholipid transport GO:0015914 35 25 0,000 0,06781011 0,08932603 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,06781011 0,0892749 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,06781011 0,08922383 ! detection of light stimulus GO:0009583 30 25 0,000 0,06781011 0,08917281 ! leukocyte proliferation GO:0070661 39 25 0,000 0,06781011 0,08912186 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,06781011 0,08907096 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,07042667 0,0924551 ! translational initiation GO:0006413 43 26 0,000 0,07042667 0,09240236 ! regulation of pH GO:0006885 36 26 0,000 0,07042667 0,09234968 ! circadian rhythm GO:0007623 42 26 0,000 0,07042667 0,09229706 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,07042667 0,0922445 ! post-embryonic development GO:0009791 42 26 0,000 0,07042667 0,092192 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,07042667 0,09213956 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,07042667 0,09208717 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,07042667 0,09203485 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,07042667 0,09198259 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,07042667 0,09193039 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,07042667 0,09187824 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,07303604 0,09522839 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,07303604 0,09517444 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,07303604 0,09512054 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! inner ear morphogenesis GO:0042472 35 27 0,000 0,07303604 0,09506671 ! catechol metabolic process GO:0009712 43 27 0,000 0,07303604 0,09501294 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,07303604 0,09495923 ! acute-phase response GO:0006953 42 27 0,000 0,07303604 0,09490558 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,07303604 0,09485199 ! myofibril assembly GO:0030239 36 27 0,000 0,07303604 0,09479847 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,07303604 0,094745 ! response to ionizing radiation GO:0010212 47 27 0,000 0,07303604 0,09469159 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,07303604 0,09463824 ! natural killer cell activation GO:0030101 35 27 0,000 0,07303604 0,09458496 ! lipid oxidation GO:0034440 38 27 0,000 0,07303604 0,09453173 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,07303604 0,09447856 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,07303604 0,09442545 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,07303604 0,09437241 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,07303604 0,09431942 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,07303604 0,09426649 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,07303604 0,09421362 ! gene silencing GO:0016458 41 27 0,000 0,07303604 0,09416081 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,07563823 0,09746102 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,07563823 0,09740645 ! phenol metabolic process GO:0018958 44 28 0,000 0,07563823 0,09735194 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,07563823 0,09729749 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,07563823 0,09724311 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,07563823 0,09718878 ! cell junction assembly GO:0034329 56 28 0,000 0,07563823 0,09713452 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,07563823 0,09708031 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,07563823 0,09702617 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,07563823 0,09697208 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,07563823 0,09691806 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,07563823 0,0968641 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,07563823 0,0968102 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,07563823 0,09675635 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,07563823 0,09670257 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,07563823 0,09664884 ! mesoderm formation GO:0001707 46 28 0,000 0,07563823 0,09659518 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,07563823 0,09654158 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,07563823 0,09648803 ! ensheathment of neurons GO:0007272 43 28 0,000 0,07563823 0,09643455 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,07563823 0,09638112 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,07563823 0,09632775 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,07563823 0,09627444 ! neural tube formation GO:0001841 41 28 0,000 0,07563823 0,09622119 ! placenta development GO:0001890 37 28 0,000 0,07563823 0,096168 ! regulation of B cell activation GO:0050864 42 28 0,000 0,07563823 0,09611487 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,07823326 0,09935754 ! regulation of innate immune response GO:0045088 38 29 0,000 0,07823326 0,0993027 ! ovulation cycle process GO:0022602 41 29 0,000 0,07823326 0,09924793 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,07823326 0,09919322 ! protein targeting to membrane GO:0006612 53 29 0,000 0,07823326 0,09913857 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,07823326 0,09908398 ! mismatch repair GO:0006298 34 29 0,000 0,07823326 0,09902944 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,07823326 0,09897497 ! muscle cell development GO:0055001 38 29 0,000 0,07823326 0,09892056 ! formation of primary germ layer GO:0001704 48 29 0,000 0,07823326 0,09886621 ! telencephalon development GO:0021537 52 29 0,000 0,07823326 0,09881192 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,07823326 0,09875768 ! eye morphogenesis GO:0048592 51 29 0,000 0,07823326 0,09870351 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,07823326 0,0986494 ! tissue homeostasis GO:0001894 42 29 0,000 0,07823326 0,09859534 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,08082116 0,10180102 ! collagen metabolic process GO:0032963 40 30 0,000 0,08082116 0,1017453 ! organic anion transport GO:0015711 51 30 0,000 0,08082116 0,10168964 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,08082116 0,10163404 ! spliceosome assembly GO:0000245 49 30 0,000 0,08082116 0,1015785 ! spindle organization GO:0007051 37 30 0,000 0,08082116 0,10152303 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,08082116 0,10146761 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,08082116 0,10141225 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,08082116 0,10135696 ! ceramide metabolic process GO:0006672 43 30 0,000 0,08082116 0,10130172 ! ovulation cycle GO:0042698 43 30 0,000 0,08082116 0,10124655 ! hindbrain development GO:0030902 45 30 0,000 0,08082116 0,10119143 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,08082116 0,10113638 ! adult locomotory behavior GO:0008344 47 30 0,000 0,08082116 0,10108138 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,08082116 0,10102645 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,08082116 0,10097157 ! response to heat GO:0009408 41 30 0,000 0,08082116 0,10091676 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,08082116 0,100862 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,08082116 0,1008073 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,08340194 0,10396989 ! negative regulation of secretion GO:0051048 49 31 0,000 0,08340194 0,10391357 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,08340194 0,10385731 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,08340194 0,10380111 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,08340194 0,10374497 ! odontogenesis GO:0042476 50 31 0,000 0,08340194 0,10368889 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,08340194 0,10363288 ! segmentation GO:0035282 41 31 0,000 0,08340194 0,10357692 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,08340194 0,10352102 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,08340194 0,10346519 ! metanephros development GO:0001656 58 31 0,000 0,08340194 0,10340941 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,08340194 0,10335369 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,08340194 0,10329804 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,08340194 0,10324244 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,08340194 0,1031869 ! RNA modification GO:0009451 40 31 0,000 0,08340194 0,10313143 ! regulation of muscle development GO:0048634 48 32 0,000 0,08597562 0,10625681 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,08597562 0,10619974 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,08597562 0,10614274 ! meiosis I GO:0007127 52 32 0,000 0,08597562 0,10608579 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,08597562 0,10602891 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,08597562 0,10597209 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,08597562 0,10591533 ! peripheral nervous system development GO:0007422 53 32 0,000 0,08597562 0,10585863 ! regulation of protein stability GO:0031647 48 32 0,000 0,08597562 0,10580199 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,08597562 0,10574541 ! cytokine production GO:0001816 44 32 0,000 0,08597562 0,10568889 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,08597562 0,10563244 ! vesicle localization GO:0051648 47 32 0,000 0,08597562 0,10557604 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,08854222 0,10866975 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,08854222 0,10861179 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,08854222 0,10855389 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,08854222 0,10849606 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,08854222 0,10843829 ! sister chromatid segregation GO:0000819 46 33 0,000 0,08854222 0,10838058 ! ear morphogenesis GO:0042471 42 33 0,000 0,08854222 0,10832293 ! actomyosin structure organization GO:0031032 43 33 0,000 0,08854222 0,10826534 ! cell junction organization GO:0034330 63 33 0,000 0,08854222 0,10820781 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,08854222 0,10815035 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,08854222 0,10809294 ! nucleus organization GO:0006997 49 33 0,000 0,08854222 0,1080356 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,08854222 0,10797832 ! female gonad development GO:0008585 49 33 0,000 0,08854222 0,10792109 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,08854222 0,10786393 ! positive regulation of cell development GO:0010720 54 33 0,000 0,08854222 0,10780683 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,08854222 0,10774979 ! regulation of proteolysis GO:0030162 50 33 0,000 0,08854222 0,10769281 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,08854222 0,10763589 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,08854222 0,10757903 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,08854222 0,10752223 ! cytokinesis GO:0000910 52 33 0,000 0,08854222 0,10746549 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,08854222 0,10740881 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,09110176 0,11045548 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,09110176 0,11039729 ! feeding behavior GO:0007631 45 34 0,000 0,09110176 0,11033915 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,09110176 0,11028108 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,09110176 0,11022307 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,09110176 0,11016512 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,09110176 0,11010722 ! neuron migration GO:0001764 46 34 0,000 0,09110176 0,1100494 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,09110176 0,10999163 ! female gamete generation GO:0007292 43 34 0,000 0,09110176 0,10993392 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,09110176 0,10987627 ! polyol metabolic process GO:0019751 44 34 0,000 0,09110176 0,10981868 ! aerobic respiration GO:0009060 47 34 0,000 0,09110176 0,10976116 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,09110176 0,10970369 ! embryonic organ development GO:0048568 45 34 0,000 0,09110176 0,10964628 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,09110176 0,10958894 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,09365426 0,11260052 ! Notch signaling pathway GO:0007219 56 35 0,000 0,09365426 0,11254169 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,09365426 0,11248292 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,09365426 0,11242422 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,09365426 0,11236557 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,09365426 0,11230699 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,09365426 0,11224846 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,09365426 0,11219 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,09365426 0,1121316 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,09365426 0,11207326 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,09365426 0,11201498 ! glycogen metabolic process GO:0005977 48 35 0,000 0,09365426 0,11195676 ! pigment metabolic process GO:0042440 61 35 0,000 0,09365426 0,1118986 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,09365426 0,1118405 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,09619974 0,11482065 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,09619974 0,1147611 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,09619974 0,1147016 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,09619974 0,11464217 ! negative regulation of binding GO:0051100 58 36 0,000 0,09619974 0,1145828 ! neural tube development GO:0021915 50 36 0,000 0,09619974 0,1145235 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,09619974 0,11446425 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,09619974 0,11440507 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,09619974 0,11434594 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,09619974 0,11428688 ! glucan metabolic process GO:0044042 49 36 0,000 0,09619974 0,11422788 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,09873821 0,11718157 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,09873821 0,11712114 ! learning GO:0007612 67 37 0,000 0,09873821 0,11706077 ! ion transmembrane transport GO:0034220 56 37 0,000 0,09873821 0,11700046 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,09873821 0,11694021 ! regulation of protein secretion GO:0050708 51 37 0,000 0,09873821 0,11688002 ! amino acid activation GO:0043038 52 37 0,000 0,09873821 0,1168199 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,09873821 0,11675984 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,1012697 0,11969183 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,1012697 0,11963036 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,1012697 0,11956895 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,1012697 0,1195076 ! phagocytosis GO:0006909 60 38 0,000 0,1012697 0,11944631 ! mesenchymal cell development GO:0014031 64 38 0,000 0,1012697 0,11938509 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,1012697 0,11932393 ! maintenance of location in cell GO:0051651 69 38 0,000 0,1012697 0,11926283 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,10379422 0,12217334 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,10379422 0,12211085 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,10379422 0,12204842 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,10379422 0,12198606 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,10379422 0,12192376 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,10379422 0,12186152 ! male sex differentiation GO:0046661 53 39 0,000 0,10379422 0,12179934 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,10379422 0,12173723 ! chromatin remodeling GO:0006338 68 39 0,000 0,10379422 0,12167519 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,10379422 0,1216132 ! JNK cascade GO:0007254 54 39 0,000 0,10379422 0,12155128 ! synapse organization GO:0050808 55 39 0,000 0,10379422 0,12148942 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,1063118 0,12437291 ! response to calcium ion GO:0051592 58 40 0,000 0,1063118 0,12430968 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,1063118 0,12424651 ! regulation of tube size GO:0035150 60 40 0,000 0,1063118 0,12418341 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,1063118 0,12412038 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,1063118 0,1240574 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,1063118 0,12399449 ! peptide metabolic process GO:0006518 56 40 0,000 0,1063118 0,12393165 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,1063118 0,12386887 ! inner ear development GO:0048839 57 40 0,000 0,1063118 0,12380615 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,1063118 0,12374349 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,1063118 0,1236809 ! double-strand break repair GO:0006302 67 40 0,000 0,1063118 0,12361837 ! B cell differentiation GO:0030183 62 40 0,000 0,1063118 0,12355591 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,1063118 0,1234935 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,1063118 0,12343117 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,1063118 0,12336889 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,1063118 0,12330668 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,10882245 0,12615506 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,10882245 0,1260915 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,10882245 0,12602801 ! glucose transport GO:0015758 52 41 0,000 0,10882245 0,12596458 ! endosome transport GO:0016197 71 41 0,000 0,10882245 0,12590122 ! striated muscle contraction GO:0006941 62 41 0,000 0,10882245 0,12583792 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,10882245 0,12577469 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,10882245 0,12571152 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,10882245 0,12564841 ! biopolymer methylation GO:0043414 62 41 0,000 0,10882245 0,12558536 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,10882245 0,12552238 ! mitochondrial transport GO:0006839 60 42 0,000 0,11132619 0,12834598 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,11132619 0,12828168 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,11132619 0,12821744 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,11132619 0,12815327 ! hexose transport GO:0008645 54 42 0,000 0,11132619 0,12808916 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,11132619 0,12802511 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,11132619 0,12796113 ! excretion GO:0007588 63 42 0,000 0,11132619 0,12789722 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,11132619 0,12783336 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,11132619 0,12776957 ! regulation of cell shape GO:0008360 78 42 0,000 0,11132619 0,12770585 ! positive regulation of binding GO:0051099 59 43 0,000 0,11382303 0,13050497 ! leukocyte migration GO:0050900 60 43 0,000 0,11382303 0,13043995 ! neuromuscular process GO:0050905 79 43 0,000 0,11382303 0,13037499 ! activation of caspase activity GO:0006919 65 43 0,000 0,11382303 0,13031009 ! tRNA processing GO:0008033 49 43 0,000 0,11382303 0,13024526 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,11382303 0,1301805 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,11382303 0,13011579 ! methylation GO:0032259 64 43 0,000 0,11382303 0,13005116 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,11631301 0,13283015 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,11631301 0,13276423 ! glycolysis GO:0006096 53 44 0,000 0,11631301 0,13269837 ! regulation of action potential GO:0001508 71 44 0,000 0,11631301 0,13263258 ! regulation of ion transport GO:0043269 57 44 0,000 0,11631301 0,13256686 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,11631301 0,1325012 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,11631301 0,1324356 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,11631301 0,13237007 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,11631301 0,13230461 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,11631301 0,13223921 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,11631301 0,13217387 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,11631301 0,1321086 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,11631301 0,1320434 ! positive regulation of defense response GO:0031349 59 45 0,000 0,11879613 0,13479581 ! regulation of translational initiation GO:0006446 64 45 0,000 0,11879613 0,13472934 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,11879613 0,13466294 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,11879613 0,1345966 ! cell recognition GO:0008037 58 45 0,000 0,11879613 0,13453033 ! cell maturation GO:0048469 60 45 0,000 0,11879613 0,13446412 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,12127241 0,13719949 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,12127241 0,13713203 ! cell redox homeostasis GO:0045454 63 46 0,000 0,12127241 0,13706465 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,12127241 0,13699732 ! regulation of ossification GO:0030278 71 46 0,000 0,12127241 0,13693007 ! histone modification GO:0016570 68 46 0,000 0,12127241 0,13686288 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,12127241 0,13679576 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,12374188 0,13951291 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,12374188 0,13944455 ! endocrine system development GO:0035270 83 47 0,000 0,12374188 0,13937626 ! covalent chromatin modification GO:0016569 75 47 0,000 0,12374188 0,13930804 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,12374188 0,13923989 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,12374188 0,1391718 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,12374188 0,13910378 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,12374188 0,13903582 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,12374188 0,13896794 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,12374188 0,13890011 ! chloride transport GO:0006821 67 48 0,000 0,12620455 0,14159535 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,12620455 0,14152631 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 0,000 0,12620455 0,14145734 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,12620455 0,14138844 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,12620455 0,14131961 ! gastrulation GO:0007369 73 48 0,000 0,12620455 0,14125084 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,12620455 0,14118214 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,12620455 0,1411135 ! regulation of endocytosis GO:0030100 63 48 0,000 0,12620455 0,14104493 ! nuclear export GO:0051168 69 48 0,000 0,12620455 0,14097643 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,12620455 0,140908 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,12620455 0,14083963 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,12866044 0,14351068 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,12866044 0,14344111 ! sensory perception of smell GO:0007608 61 49 0,000 0,12866044 0,14337162 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,12866044 0,14330219 ! RNA elongation GO:0006354 62 49 0,000 0,12866044 0,14323283 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,12866044 0,14316353 ! germ cell development GO:0007281 68 49 0,000 0,12866044 0,1430943 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,12866044 0,14302514 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,12866044 0,14295605 ! cartilage development GO:0051216 70 49 0,000 0,12866044 0,14288702 ! maintenance of location GO:0051235 84 49 0,000 0,12866044 0,14281806 ! regulation of actin filament length GO:0030832 72 50 0,000 0,13110957 0,14546648 ! ear development GO:0043583 72 50 0,000 0,13110957 0,14539634 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,13110957 0,14532627 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,13110957 0,14525627 ! proton transport GO:0015992 75 50 0,000 0,13110957 0,14518633 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,13110957 0,14511646 ! positive regulation of secretion GO:0051047 71 51 0,000 0,13355195 0,14774867 ! hydrogen transport GO:0006818 77 51 0,000 0,13355195 0,14767764 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,13355195 0,14760668 ! adult behavior GO:0030534 80 51 0,000 0,13355195 0,14753578 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,13355195 0,14746495 ! transition metal ion transport GO:0000041 74 52 0,000 0,13598761 0,1500823 ! regulation of cellular component size GO:0032535 74 52 0,000 0,13598761 0,15001031 ! aging GO:0007568 79 52 0,000 0,13598761 0,1499384 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,13598761 0,14986656 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,13598761 0,14979478 ! establishment of organelle localization GO:0051656 85 52 0,000 0,13598761 0,14972308 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,13841656 0,15232445 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,13841656 0,1522516 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,13841656 0,15217882 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,13841656 0,15210611 ! kidney development GO:0001822 90 53 0,000 0,13841656 0,15203347 ! single fertilization GO:0007338 59 53 0,000 0,13841656 0,1519609 ! cell projection assembly GO:0030031 76 53 0,000 0,13841656 0,1518884 ! amino acid transport GO:0006865 84 54 0,000 0,14083882 0,15447272 ! glucose catabolic process GO:0006007 66 54 0,000 0,14083882 0,15439909 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,14083882 0,15432553 ! DNA catabolic process GO:0006308 67 54 0,000 0,14083882 0,15425204 ! detection of external stimulus GO:0009581 66 54 0,000 0,14083882 0,15417863 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,14083882 0,15410528 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,14083882 0,154032 ! exocytosis GO:0006887 74 55 0,000 0,14325441 0,15659941 ! mesoderm development GO:0007498 76 55 0,000 0,14325441 0,15652501 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,14325441 0,15645069 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,14325441 0,15637644 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,14566335 0,1589306 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,14566335 0,15885524 ! carbohydrate transport GO:0008643 74 57 0,000 0,14806565 0,16139858 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,14806565 0,16132212 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,14806565 0,16124574 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,14806565 0,16116942 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,14806565 0,16109319 ! camera-type eye development GO:0043010 88 57 0,000 0,14806565 0,16101702 ! secondary metabolic process GO:0019748 84 57 0,000 0,14806565 0,16094092 ! developmental maturation GO:0021700 75 57 0,000 0,14806565 0,1608649 ! gonad development GO:0008406 79 57 0,000 0,14806565 0,16078895 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,15046133 0,16331339 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,15046133 0,16323635 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,15046133 0,16315939 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,15285042 0,16567199 ! actin filament organization GO:0007015 95 59 0,000 0,15285042 0,16559395 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,15285042 0,16551599 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,15285042 0,1654381 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,15523292 0,16793778 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,15523292 0,16785882 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,15523292 0,16777994 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,15523292 0,16770113 ! regulation of heart contraction GO:0008016 91 60 0,000 0,15523292 0,1676224 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,15523292 0,16754374 ! fertilization GO:0009566 68 60 0,000 0,15523292 0,16746516 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,15523292 0,16738664 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,15760886 0,16986896 ! meiosis GO:0007126 96 61 0,000 0,15760886 0,1697894 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,15760886 0,16970991 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,15760886 0,1696305 ! urogenital system development GO:0001655 101 61 0,000 0,15760886 0,16955116 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,15760886 0,16947189 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,15760886 0,1693927 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,15760886 0,16931358 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,15760886 0,16923453 ! amine catabolic process GO:0009310 90 62 0,000 0,15997825 0,17169854 ! neurotransmitter transport GO:0006836 81 62 0,000 0,15997825 0,17161846 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,15997825 0,17153845 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,15997825 0,17145851 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,15997825 0,17137865 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,15997825 0,17129887 ! meiotic cell cycle GO:0051321 97 62 0,000 0,15997825 0,17121916 ! organelle localization GO:0051640 96 62 0,000 0,15997825 0,17113952 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,16234111 0,1735865 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,16234111 0,17350583 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,16469746 0,17594248 ! negative regulation of cell size GO:0045792 108 64 0,000 0,16469746 0,1758608 ! appendage morphogenesis GO:0035107 93 64 0,000 0,16469746 0,17577919 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,16469746 0,17569766 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,16469746 0,17561621 ! hexose catabolic process GO:0019320 82 64 0,000 0,16469746 0,17553483 ! adaptive immune response GO:0002250 94 64 0,000 0,16469746 0,17545353 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,16704732 0,17787446 ! regulation of caspase activity GO:0043281 97 65 0,000 0,16704732 0,17779215 ! appendage development GO:0048736 94 65 0,000 0,16704732 0,17770991 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,16704732 0,17762776 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,16704732 0,17754567 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,16704732 0,17746367 ! defense response to bacterium GO:0042742 73 65 0,000 0,16704732 0,17738173 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,16704732 0,17729988 ! activation of immune response GO:0002253 83 65 0,000 0,16704732 0,1772181 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,1693907 0,17962131 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,1693907 0,17953853 ! antigen processing and presentation GO:0019882 96 66 0,000 0,1693907 0,17945583 ! axon guidance GO:0007411 99 66 0,000 0,1693907 0,17937321 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,1693907 0,17929066 ! regulation of immune effector process GO:0002697 101 66 0,000 0,1693907 0,17920819 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,17172762 0,18159703 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,17172762 0,18151357 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,17172762 0,1814302 ! acute inflammatory response GO:0002526 92 68 0,000 0,17405811 0,18380792 ! learning or memory GO:0007611 123 68 0,000 0,17405811 0,18372356 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,17405811 0,18363929 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,17405811 0,18355509 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,17405811 0,18347097 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,17405811 0,18338692 ! rhythmic process GO:0048511 105 68 0,000 0,17405811 0,18330295 ! inorganic anion transport GO:0015698 93 68 0,000 0,17405811 0,18321906 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,17638217 0,1855805 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,17638217 0,18549565 ! response to drug GO:0042493 108 69 0,000 0,17638217 0,18541087 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,17638217 0,18532617 ! response to metal ion GO:0010038 103 70 0,000 0,17869982 0,18767561 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,17869982 0,18758995 ! humoral immune response GO:0006959 86 70 0,000 0,17869982 0,18750437 ! eye development GO:0001654 111 70 0,000 0,17869982 0,18741887 ! amine transport GO:0015837 101 70 0,000 0,17869982 0,18733345 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,17869982 0,1872481 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,18101108 0,18958355 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,18101108 0,18949726 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,18101108 0,18941105 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,18101108 0,18932491 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,18101108 0,18923886 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,18331597 0,19156144 ! negative regulation of transport GO:0051051 116 73 0,000 0,18561451 0,19387528 ! regulation of blood pressure GO:0008217 107 73 0,000 0,18561451 0,19378728 ! mitochondrion organization GO:0007005 104 73 0,000 0,18561451 0,19369935 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,18561451 0,1936115 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,18561451 0,19352374 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,18790671 0,19582484 ! digestion GO:0007586 97 74 0,000 0,18790671 0,19573615 ! protein import into nucleus GO:0006606 118 74 0,000 0,18790671 0,19564754 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,18790671 0,19555902 ! blood coagulation GO:0007596 116 75 0,000 0,19019258 0,19784846 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,19019258 0,19775902 ! negative regulation of growth GO:0045926 123 75 0,000 0,19019258 0,19766965 ! regulation of ligase activity GO:0051340 114 75 0,000 0,19019258 0,19758037 ! nuclear import GO:0051170 121 75 0,000 0,19019258 0,19749117 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,19019258 0,19740205 ! amine biosynthetic process GO:0009309 97 76 0,000 0,19247216 0,19967793 ! tRNA metabolic process GO:0006399 95 76 0,000 0,19247216 0,1995879 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,19247216 0,19949796 ! regulation of protein transport GO:0051223 114 76 0,000 0,19247216 0,19940809 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,19474545 0,20167246 ! regulation of DNA binding GO:0051101 119 77 0,000 0,19474545 0,2015817 ! sex differentiation GO:0007548 105 77 0,000 0,19474545 0,20149102 ! protein ubiquitination GO:0016567 125 77 0,000 0,19474545 0,20140042 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,19474545 0,2013099 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,19474545 0,20121947 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,19474545 0,20112911 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,19701247 0,20337912 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,19701247 0,20328788 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,19927324 0,20552845 ! cellular respiration GO:0045333 107 79 0,000 0,19927324 0,20543632 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,19927324 0,20534428 ! T cell activation GO:0042110 134 79 0,000 0,19927324 0,20525232 ! regulation of lyase activity GO:0051339 133 79 0,000 0,19927324 0,20516045 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,19927324 0,20506865 ! chromatin assembly GO:0031497 102 80 0,000 0,20152777 0,207296 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,20152777 0,20720334 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,20152777 0,20711075 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,20152777 0,20701825 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,20152777 0,20692583 ! forebrain development GO:0030900 131 80 0,000 0,20152777 0,2068335 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,20377608 0,20904772 ! hemostasis GO:0007599 125 81 0,000 0,20377608 0,20895452 ! mRNA transport GO:0051028 121 81 0,000 0,20377608 0,2088614 ! regulation of neurological system process GO:0031644 122 81 0,000 0,20377608 0,20876837 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,20377608 0,20867542 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 0,000 0,20601819 0,21087754 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,20825412 0,21307138 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,20825412 0,21297664 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,20825412 0,21288199 ! regulation of defense response GO:0031347 117 84 0,000 0,21048387 0,21506571 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,21048387 0,21497021 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,21048387 0,21487479 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,21270748 0,21704845 ! rRNA metabolic process GO:0016072 107 85 0,000 0,21270748 0,2169522 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,21270748 0,21685603 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,21270748 0,21675995 ! regulation of protein localization GO:0032880 132 85 0,000 0,21270748 0,21666395 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,21492495 0,21882576 ! cell cycle arrest GO:0007050 150 86 0,000 0,21492495 0,21872893 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,2171363 0,22088169 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,2171363 0,22078404 ! female pregnancy GO:0007565 130 87 0,000 0,2171363 0,22068648 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,2171363 0,220589 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,21934155 0,22273093 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,21934155 0,22263264 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,21934155 0,22253444 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,21934155 0,22243632 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,22154072 0,22456749 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,22154072 0,22446857 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,22154072 0,22436973 ! regulation of T cell activation GO:0050863 128 89 0,000 0,22154072 0,22427097 ! leukocyte differentiation GO:0002521 143 90 0,000 0,22373381 0,22639145 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,22373381 0,22629189 ! hormone metabolic process GO:0042445 121 90 0,000 0,22373381 0,22619242 ! RNA localization GO:0006403 135 91 0,000 0,22592085 0,22830315 ! ATP metabolic process GO:0046034 137 91 0,000 0,22592085 0,22820288 ! response to virus GO:0009615 122 91 0,000 0,22592085 0,22810271 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,22810186 0,23020372 ! positive regulation of immune response GO:0050778 121 92 0,000 0,22810186 0,23010275 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,23027685 0,23219498 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,23027685 0,23209323 ! electron transport chain GO:0022900 123 94 0,000 0,23244583 0,2341767 ! response to oxidative stress GO:0006979 141 94 0,000 0,23244583 0,23407417 ! regulation of binding GO:0051098 151 95 0,000 0,23460882 0,23614892 ! carboxylic acid transport GO:0046942 147 95 0,000 0,23460882 0,23604562 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,23676585 0,23811169 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,23676585 0,23800763 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,23676585 0,23790365 ! protein maturation GO:0051604 129 96 0,000 0,23676585 0,23779976 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,23891691 0,23985548 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,23891691 0,23975083 ! protein import GO:0017038 156 99 0,000 0,24320125 0,24394369 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,24320125 0,24383735 ! regulation of translation GO:0006417 151 100 0,000 0,24533455 0,24586905 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,24533455 0,24576196 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,24533455 0,24565497 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,24533455 0,24554807 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,24533455 0,24544126 ! protein localization in organelle GO:0033365 161 100 0,000 0,24533455 0,24533455