pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1245-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! peptidyl-amino acid modification GO:0018193 147 93 7,000 2,77E-07 6,371E-04 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 5,826E-07 6,7E-04 ! gland morphogenesis GO:0022612 23 12 3,000 1,07E-06 8,205E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 2,141E-06 1,231E-03 ! response to peptide hormone stimulus GO:0043434 84 57 5,000 2,769E-06 1,274E-03 ! positive regulation of vasoconstriction GO:0045907 9 5 2,000 3,282E-06 1,258E-03 ! positive regulation of microtubule polymerization GO:0031116 9 5 2,000 3,282E-06 1,078E-03 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 3,607E-06 1,037E-03 ! protein oligomerization GO:0051259 100 65 5,000 6,024E-06 1,539E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 6,405E-06 1,473E-03 ! gas homeostasis GO:0033483 11 6 2,000 6,531E-06 1,366E-03 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 2,000 6,531E-06 1,252E-03 ! regulation of microtubule polymerization GO:0031113 11 6 2,000 6,531E-06 1,156E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 1,003E-05 1,648E-03 ! regulation of peptidase activity GO:0052547 106 72 5,000 1,095E-05 1,679E-03 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 1,137E-05 1,635E-03 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 2,000 1,137E-05 1,538E-03 ! response to insulin stimulus GO:0032868 63 43 4,000 1,187E-05 1,516E-03 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 1,284E-05 1,554E-03 ! gland development GO:0048732 148 77 5,000 1,615E-05 1,857E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 1,804E-05 1,976E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 1,81E-05 1,892E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,81E-05 1,81E-03 ! ear development GO:0043583 72 50 4,000 2,512E-05 2,408E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 2,549E-05 2,345E-03 ! regulation of epithelial cell differentiation GO:0030856 13 9 2,000 2,701E-05 2,39E-03 ! positive regulation of protein polymerization GO:0032273 15 9 2,000 2,701E-05 2,301E-03 ! positive regulation of cell migration GO:0030335 92 51 4,000 2,77E-05 2,275E-03 ! negative regulation of MAPKKK cascade GO:0043409 20 10 2,000 3,839E-05 3,045E-03 ! cholesterol homeostasis GO:0042632 46 28 3,000 4,06E-05 3,113E-03 GO:0055092|sterol homeostasis, ! regulation of lipid metabolic process GO:0019216 84 56 4,000 4,381E-05 3,25E-03 ! positive regulation of cell motion GO:0051272 99 56 4,000 4,381E-05 3,149E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 4,775E-05 3,328E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 5,197E-05 3,515E-03 ! focal adhesion formation GO:0048041 24 11 2,000 5,252E-05 3,451E-03 ! mammary gland development GO:0030879 57 31 3,000 6,139E-05 3,922E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 6,636E-05 4,125E-03 ! mitotic sister chromatid segregation GO:0000070 45 32 3,000 6,979E-05 4,224E-03 ! sister chromatid segregation GO:0000819 46 33 3,000 7,899E-05 4,658E-03 ! lipid homeostasis GO:0055088 55 33 3,000 7,899E-05 4,542E-03 ! positive regulation of protein complex assembly GO:0031334 19 13 2,000 9,011E-05 5,055E-03 ! lipid localization GO:0010876 24 13 2,000 9,011E-05 4,935E-03 GO:0019915|lipid storage, ! protein homooligomerization GO:0051260 52 35 3,000 9,999E-05 5,348E-03 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 2,000 1,141E-04 5,965E-03 ! pigmentation GO:0043473 74 38 3,000 1,387E-04 7,089E-03 ! negative regulation of cell cycle process GO:0010948 24 15 2,000 1,419E-04 7,095E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 1,419E-04 6,944E-03 ! regulation of vasodilation GO:0042312 24 15 2,000 1,419E-04 6,8E-03 ! mitochondrion organization GO:0007005 104 73 4,000 1,567E-04 7,357E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 2,099E-04 9,657E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,099E-04 9,467E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 2,099E-04 9,285E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 2,099E-04 9,11E-03 ! vesicle organization GO:0016050 79 43 3,000 2,257E-04 9,615E-03 ! forebrain development GO:0030900 131 80 4,000 2,413E-04 0,01009058 ! positive regulation of DNA replication GO:0045740 29 18 2,000 2,506E-04 0,01029387 ! positive regulation of cytoskeleton organization GO:0051495 33 18 2,000 2,506E-04 0,01011328 ! negative regulation of neuron differentiation GO:0045665 24 18 2,000 2,506E-04 9,939E-03 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 2,000 2,506E-04 9,77E-03 ! response to alkaloid GO:0043279 32 19 2,000 2,961E-04 0,01135105 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 2,961E-04 0,01116497 ! regulation of fatty acid metabolic process GO:0019217 28 19 2,000 2,961E-04 0,01098489 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 2,961E-04 0,01081052 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 2,000 2,961E-04 0,01064161 ! regulation of membrane potential GO:0042391 128 85 4,000 3,202E-04 0,01133155 ! regulation of muscle contraction GO:0006937 69 48 3,000 3,465E-04 0,01207424 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 4,023E-04 0,01381071 ! regulation of vasoconstriction GO:0019229 31 21 2,000 4,023E-04 0,01360761 ! response to glucocorticoid stimulus GO:0051384 33 21 2,000 4,023E-04 0,0134104 ! positive regulation of organelle organization GO:0010638 82 51 3,000 4,379E-04 0,01438722 ! vasculogenesis GO:0001570 33 22 2,000 4,635E-04 0,01501379 ! regulation of smooth muscle contraction GO:0006940 36 22 2,000 4,635E-04 0,01480526 ! membrane depolarization GO:0051899 35 22 2,000 4,635E-04 0,01460245 ! regulation of blood coagulation GO:0030193 34 22 2,000 4,635E-04 0,01440512 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 4,764E-04 0,01461104 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 1,000 4,764E-04 0,01441879 ! positive regulation of glycolysis GO:0045821 11 5 1,000 4,764E-04 0,01423153 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 1,000 4,764E-04 0,01404907 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! epithelial cell proliferation GO:0050673 6 5 1,000 4,764E-04 0,01387124 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 4,764E-04 0,01369785 ! positive regulation of neuroblast proliferation GO:0002052 8 5 1,000 4,764E-04 0,01352874 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 4,764E-04 0,01336375 ! peptidyl-histidine phosphorylation GO:0018106 7 5 1,000 4,764E-04 0,01320274 ! 5S class rRNA transcription GO:0042791 8 5 1,000 4,764E-04 0,01304557 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 4,764E-04 0,01289209 ! regulation of respiratory burst GO:0060263 8 5 1,000 4,764E-04 0,01274218 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 4,764E-04 0,01259572 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 4,764E-04 0,01245259 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 5,303E-04 0,01370395 ! response to corticosteroid stimulus GO:0031960 36 23 2,000 5,303E-04 0,01355169 ! regulation of mitosis GO:0007088 84 54 3,000 5,453E-04 0,01378181 GO:0051783|regulation of nuclear division, ! regulation of response to external stimulus GO:0032101 139 96 4,000 5,615E-04 0,01403726 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 6,03E-04 0,01491197 ! chromosome segregation GO:0007059 83 57 3,000 6,702E-04 0,01639862 ! regulation of cellular ketone metabolic process GO:0010565 34 25 2,000 6,817E-04 0,01650451 ! iron ion homeostasis GO:0055072 39 25 2,000 6,817E-04 0,01633259 ! regulation of chromosome organization GO:0033044 35 25 2,000 6,817E-04 0,01616421 ! tRNA transcription GO:0009304 11 6 1,000 7,114E-04 0,01669623 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 7,114E-04 0,01652758 ! negative regulation of endocytosis GO:0045806 8 6 1,000 7,114E-04 0,01636231 ! pigment granule organization GO:0048753 11 6 1,000 7,114E-04 0,01620031 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 1,000 7,114E-04 0,01604148 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! ER overload response GO:0006983 7 6 1,000 7,114E-04 0,01588574 ! male sex determination GO:0030238 9 6 1,000 7,114E-04 0,01573299 ! spindle checkpoint GO:0031577 14 6 1,000 7,114E-04 0,01558315 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 7,114E-04 0,01543614 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 7,114E-04 0,01529188 ! peptidyl-histidine modification GO:0018202 9 6 1,000 7,114E-04 0,01515029 ! midbrain development GO:0030901 6 6 1,000 7,114E-04 0,01501129 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 7,667E-04 0,01603137 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 7,667E-04 0,01588694 ! regulation of coagulation GO:0050818 39 26 2,000 7,667E-04 0,01574509 ! cell-matrix adhesion GO:0007160 114 61 3,000 8,666E-04 0,01763952 ! cell junction assembly GO:0034329 56 28 2,000 9,563E-04 0,01929363 ! triglyceride metabolic process GO:0006641 34 28 2,000 9,563E-04 0,01912586 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 9,563E-04 0,01896098 ! positive regulation of catabolic process GO:0009896 40 28 2,000 9,563E-04 0,01879893 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 1,000 9,914E-04 0,01932425 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 9,914E-04 0,01916186 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 9,914E-04 0,01900218 ! regulation of pigmentation during development GO:0048070 15 7 1,000 9,914E-04 0,01884514 ! vesicle fusion GO:0006906 15 7 1,000 9,914E-04 0,01869067 ! organ growth GO:0035265 11 7 1,000 9,914E-04 0,01853871 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 9,914E-04 0,01838921 ! behavioral fear response GO:0001662 13 7 1,000 9,914E-04 0,01824209 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 9,914E-04 0,01809731 ! response to UV-B GO:0010224 11 7 1,000 9,914E-04 0,01795482 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 1,000 9,914E-04 0,01781454 ! B cell lineage commitment GO:0002326 17 7 1,000 9,914E-04 0,01767645 ! T cell lineage commitment GO:0002360 12 7 1,000 9,914E-04 0,01754047 ! peptidyl-threonine modification GO:0018210 18 7 1,000 9,914E-04 0,01740658 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 9,914E-04 0,01727471 ! cell cycle checkpoint GO:0000075 108 64 3,000 1,038E-03 0,01795625 ! regulation of caspase activity GO:0043281 97 65 3,000 1,101E-03 0,0188895 ! cell-substrate adhesion GO:0031589 121 66 3,000 1,165E-03 0,01985267 ! cholesterol transport GO:0030301 46 30 2,000 1,173E-03 0,01984038 GO:0015918|sterol transport, ! spindle organization GO:0007051 37 30 2,000 1,173E-03 0,01969556 ! hindbrain development GO:0030902 45 30 2,000 1,173E-03 0,01955284 ! regulation of microtubule-based process GO:0032886 58 30 2,000 1,173E-03 0,01941217 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 1,233E-03 0,02025043 ! regulation of neuron differentiation GO:0045664 107 67 3,000 1,233E-03 0,02010681 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,316E-03 0,02131318 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,316E-03 0,02116413 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,316E-03 0,02101716 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 1,316E-03 0,02087222 ! melanin metabolic process GO:0006582 12 8 1,000 1,316E-03 0,02072926 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,316E-03 0,02058824 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,316E-03 0,02044913 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,316E-03 0,02031189 ! branched chain family amino acid catabolic process GO:0009083 11 8 1,000 1,316E-03 0,02017648 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,316E-03 0,02004286 ! regulation of embryonic development GO:0045995 16 8 1,000 1,316E-03 0,019911 ! response to drug GO:0042493 108 69 3,000 1,375E-03 0,02067703 ! meiosis I GO:0007127 52 32 2,000 1,419E-03 0,02118919 ! neutral lipid metabolic process GO:0006638 41 32 2,000 1,419E-03 0,02105249 GO:0006639|acylglycerol metabolic process, ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 1,553E-03 0,02289283 ! ear morphogenesis GO:0042471 42 33 2,000 1,553E-03 0,02274702 ! cell junction organization GO:0034330 63 33 2,000 1,553E-03 0,02260305 ! positive regulation of cell development GO:0010720 54 33 2,000 1,553E-03 0,02246089 ! response to hypoxia GO:0001666 132 72 3,000 1,611E-03 0,02315544 ! regulation of developmental growth GO:0048638 13 9 1,000 1,684E-03 0,02405855 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,684E-03 0,02391004 ! regulation of glycolysis GO:0006110 15 9 1,000 1,684E-03 0,02376335 ! T cell selection GO:0045058 18 9 1,000 1,684E-03 0,02361845 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,684E-03 0,02347531 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 1,000 1,684E-03 0,02333389 ! oocyte differentiation GO:0009994 12 9 1,000 1,684E-03 0,02319417 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 1,684E-03 0,02305611 ! spleen development GO:0048536 15 9 1,000 1,684E-03 0,02291968 ! sequestering of metal ion GO:0051238 11 9 1,000 1,684E-03 0,02278486 ! response to nicotine GO:0035094 16 9 1,000 1,684E-03 0,02265161 ! development of primary male sexual characteristics GO:0046546 44 34 2,000 1,694E-03 0,02265739 ! glycerol ether metabolic process GO:0006662 44 34 2,000 1,694E-03 0,02252643 ! response to steroid hormone stimulus GO:0048545 114 73 3,000 1,695E-03 0,0224066 ! response to oxygen levels GO:0070482 137 74 3,000 1,782E-03 0,02342608 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 1,844E-03 0,02409581 ! glycogen metabolic process GO:0005977 48 35 2,000 1,844E-03 0,02395968 ! response to reactive oxygen species GO:0000302 55 36 2,000 2,001E-03 0,02585956 ! organic ether metabolic process GO:0018904 46 36 2,000 2,001E-03 0,0257151 ! tissue remodeling GO:0048771 62 36 2,000 2,001E-03 0,02557223 ! glucan metabolic process GO:0044042 49 36 2,000 2,001E-03 0,02543095 GO:0006073|cellular glucan metabolic process, ! hair follicle morphogenesis GO:0031069 17 10 1,000 2,096E-03 0,0264819 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,096E-03 0,02633719 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,096E-03 0,02619405 ! B cell proliferation GO:0042100 14 10 1,000 2,096E-03 0,02605246 ! fear response GO:0042596 16 10 1,000 2,096E-03 0,0259124 ! negative regulation of ossification GO:0030279 19 10 1,000 2,096E-03 0,02577383 ! alpha-beta T cell activation GO:0046631 16 10 1,000 2,096E-03 0,02563673 ! response to dsRNA GO:0043331 18 10 1,000 2,096E-03 0,02550109 ! DNA methylation GO:0006306 15 10 1,000 2,096E-03 0,02536687 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 1,000 2,096E-03 0,02523406 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,096E-03 0,02510263 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of cell cycle process GO:0010564 122 81 3,000 2,483E-03 0,02958671 ! male sex differentiation GO:0046661 53 39 2,000 2,523E-03 0,02991158 ! rRNA transcription GO:0009303 17 11 1,000 2,55E-03 0,03007132 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 1,000 2,55E-03 0,02991789 ! RNA polyadenylation GO:0043631 19 11 1,000 2,55E-03 0,02976602 ! virus-host interaction GO:0019048 17 11 1,000 2,55E-03 0,02961569 ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,55E-03 0,02946687 ! adult heart development GO:0007512 11 11 1,000 2,55E-03 0,02931953 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 2,55E-03 0,02917367 ! T cell homeostasis GO:0043029 20 11 1,000 2,55E-03 0,02902924 ! male genitalia development GO:0030539 13 11 1,000 2,55E-03 0,02888624 ! digestive tract morphogenesis GO:0048546 15 11 1,000 2,55E-03 0,02874464 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! mRNA 3'-end processing GO:0031124 19 11 1,000 2,55E-03 0,02860442 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 2,714E-03 0,03029935 ! inner ear development GO:0048839 57 40 2,000 2,714E-03 0,03015298 ! JAK-STAT cascade GO:0007259 53 40 2,000 2,714E-03 0,03000801 ! positive regulation of protein transport GO:0051222 55 40 2,000 2,714E-03 0,02986443 ! energy reserve metabolic process GO:0006112 59 41 2,000 2,913E-03 0,03190681 ! biopolymer methylation GO:0043414 62 41 2,000 2,913E-03 0,03175559 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 2,958E-03 0,03208818 ! transcription initiation GO:0006352 118 85 3,000 2,958E-03 0,03193753 ! regulation of protein localization GO:0032880 132 85 3,000 2,958E-03 0,03178829 ! negative regulation of multicellular organismal process GO:0051241 133 85 3,000 2,958E-03 0,03164044 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 3,045E-03 0,03242888 ! auditory receptor cell differentiation GO:0042491 25 12 1,000 3,045E-03 0,03227944 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 3,045E-03 0,03213137 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 3,045E-03 0,03198465 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone methylation GO:0016571 15 12 1,000 3,045E-03 0,03183927 ! response to gamma radiation GO:0010332 20 12 1,000 3,045E-03 0,0316952 ! RNA 3'-end processing GO:0031123 20 12 1,000 3,045E-03 0,03155243 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 3,085E-03 0,0318233 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 3,121E-03 0,03205103 ! regulation of JAK-STAT cascade GO:0046425 61 42 2,000 3,121E-03 0,03190858 ! cellular component disassembly GO:0022411 64 42 2,000 3,121E-03 0,03176739 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 3,339E-03 0,03382796 ! activation of caspase activity GO:0006919 65 43 2,000 3,339E-03 0,0336796 ! methylation GO:0032259 64 43 2,000 3,339E-03 0,03353252 ! interphase GO:0051325 159 88 3,000 3,352E-03 0,03352258 ! regulation of neurogenesis GO:0050767 153 89 3,000 3,491E-03 0,03476245 ! reproductive developmental process GO:0003006 127 89 3,000 3,491E-03 0,03461261 ! regulation of inflammatory response GO:0050727 60 44 2,000 3,565E-03 0,03518995 ! organelle fusion GO:0048284 28 13 1,000 3,583E-03 0,03521592 ! endocrine pancreas development GO:0031018 19 13 1,000 3,583E-03 0,03506606 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 3,583E-03 0,03491748 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 3,583E-03 0,03477015 ! genitalia development GO:0048806 15 13 1,000 3,583E-03 0,03462406 ! cellular pigmentation GO:0033059 24 13 1,000 3,583E-03 0,03447919 ! regulation of RNA stability GO:0043487 28 13 1,000 3,583E-03 0,03433552 ! lymphocyte homeostasis GO:0002260 24 13 1,000 3,583E-03 0,03419305 ! positive regulation of cell cycle GO:0045787 77 45 2,000 3,8E-03 0,03611828 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 3,8E-03 0,03596965 ! cell fate commitment GO:0045165 141 92 3,000 3,932E-03 0,03706507 ! regulation of ossification GO:0030278 71 46 2,000 4,045E-03 0,03797267 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 4,161E-03 0,03890327 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,161E-03 0,03874577 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 4,161E-03 0,03858954 ! epidermis morphogenesis GO:0048730 29 14 1,000 4,161E-03 0,03843456 ! pituitary gland development GO:0021983 23 14 1,000 4,161E-03 0,03828082 ! cellular response to starvation GO:0009267 21 14 1,000 4,161E-03 0,03812831 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 4,161E-03 0,03797701 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 27 14 1,000 4,161E-03 0,0378269 ! negative regulation of inflammatory response GO:0050728 16 14 1,000 4,161E-03 0,03767797 ! muscle maintenance GO:0046716 19 14 1,000 4,161E-03 0,03753022 ! response to oxidative stress GO:0006979 141 94 3,000 4,246E-03 0,03814779 ! response to estrogen stimulus GO:0043627 74 47 2,000 4,299E-03 0,03847294 ! endocrine system development GO:0035270 83 47 2,000 4,299E-03 0,03832382 ! regulation of protein polymerization GO:0032271 71 47 2,000 4,299E-03 0,03817585 ! positive regulation of caspase activity GO:0043280 72 48 2,000 4,562E-03 0,04035996 GO:0010952|positive regulation of peptidase activity, ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 4,562E-03 0,04020532 ! regulation of DNA replication GO:0006275 75 48 2,000 4,562E-03 0,04005187 ! metencephalon development GO:0022037 19 15 1,000 4,779E-03 0,04179594 ! lipid phosphorylation GO:0046834 23 15 1,000 4,779E-03 0,04163762 ! adult walking behavior GO:0007628 25 15 1,000 4,779E-03 0,0414805 ! positive regulation of proteolysis GO:0045862 19 15 1,000 4,779E-03 0,04132455 ! regulation of survival gene product expression GO:0045884 20 15 1,000 4,779E-03 0,04116978 ! neuron recognition GO:0008038 22 15 1,000 4,779E-03 0,04101616 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 4,779E-03 0,04086369 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 4,779E-03 0,04071234 ! defense response to virus GO:0051607 27 15 1,000 4,779E-03 0,04056211 ! regulation of intracellular transport GO:0032386 78 49 2,000 4,836E-03 0,04088848 ! calcium ion transport GO:0006816 167 99 3,000 5,104E-03 0,04299923 ! membrane fusion GO:0006944 80 50 2,000 5,118E-03 0,0429635 ! positive regulation of growth GO:0045927 67 50 2,000 5,118E-03 0,04280727 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 5,118E-03 0,04265217 ! divalent metal ion transport GO:0070838 171 100 3,000 5,288E-03 0,04391003 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 5,411E-03 0,04476548 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 5,437E-03 0,04482283 ! fructose metabolic process GO:0006000 20 16 1,000 5,437E-03 0,04466275 ! regulation of protein binding GO:0043393 27 16 1,000 5,437E-03 0,04450381 ! diencephalon development GO:0021536 25 16 1,000 5,437E-03 0,04434599 ! oogenesis GO:0048477 23 16 1,000 5,437E-03 0,04418929 ! G1 phase GO:0051318 27 16 1,000 5,437E-03 0,0440337 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 5,437E-03 0,04387919 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 5,437E-03 0,04372577 ! inner ear receptor cell differentiation GO:0060113 30 16 1,000 5,437E-03 0,04357341 ! negative regulation of translation GO:0017148 22 16 1,000 5,437E-03 0,04342212 ! regulation of bone remodeling GO:0046850 90 53 2,000 6,026E-03 0,04795384 ! negative regulation of defense response GO:0031348 19 17 1,000 6,134E-03 0,04865035 ! keratinization GO:0031424 17 17 1,000 6,134E-03 0,04848317 ! regulation of viral genome replication GO:0045069 24 17 1,000 6,134E-03 0,04831713 ! regulation of striated muscle contraction GO:0006942 20 17 1,000 6,134E-03 0,04815222 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 6,134E-03 0,04798844 ! actin filament bundle formation GO:0051017 26 17 1,000 6,134E-03 0,04782577 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 6,134E-03 0,04766419 ! regulation of protein complex assembly GO:0043254 81 54 2,000 6,348E-03 0,04915859 ! DNA catabolic process GO:0006308 67 54 2,000 6,348E-03 0,04899363 ! regulation of tissue remodeling GO:0034103 91 54 2,000 6,348E-03 0,04882977 ! transcription from RNA polymerase III promoter GO:0006383 32 18 1,000 6,87E-03 0,05266706 ! mechanoreceptor differentiation GO:0042490 32 18 1,000 6,87E-03 0,05249209 ! pancreas development GO:0031016 26 18 1,000 6,87E-03 0,05231828 ! pigmentation during development GO:0048066 31 18 1,000 6,87E-03 0,05214561 ! central nervous system neuron development GO:0021954 30 18 1,000 6,87E-03 0,05197408 ! cellular response to nutrient levels GO:0031669 27 18 1,000 6,87E-03 0,05180367 ! gut development GO:0048565 26 18 1,000 6,87E-03 0,05163438 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 7,023E-03 0,05261545 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 7,643E-03 0,05707413 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 7,643E-03 0,05688942 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 7,643E-03 0,05670591 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 7,643E-03 0,05652357 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regeneration GO:0031099 32 19 1,000 7,643E-03 0,05634241 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 7,643E-03 0,0561624 ! apoptotic nuclear changes GO:0030262 24 19 1,000 7,643E-03 0,05598354 ! response to starvation GO:0042594 30 19 1,000 7,643E-03 0,05580581 ! sex determination GO:0007530 29 19 1,000 7,643E-03 0,05562921 ! renal system process GO:0003014 35 19 1,000 7,643E-03 0,05545373 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 7,643E-03 0,05527934 ! lung development GO:0030324 94 59 2,000 8,113E-03 0,05849424 ! actin filament organization GO:0007015 95 59 2,000 8,113E-03 0,05831145 ! protein amino acid O-linked glycosylation GO:0006493 29 20 1,000 8,454E-03 0,06057153 ! response to ethanol GO:0045471 37 20 1,000 8,454E-03 0,06038342 ! multicellular organismal response to stress GO:0033555 32 20 1,000 8,454E-03 0,06019647 ! central nervous system neuron differentiation GO:0021953 33 20 1,000 8,454E-03 0,06001068 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 8,454E-03 0,05982603 ! DNA modification GO:0006304 28 20 1,000 8,454E-03 0,05964251 ! positive regulation of inflammatory response GO:0050729 30 20 1,000 8,454E-03 0,05946012 ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 8,454E-03 0,05927884 ! phosphoinositide metabolic process GO:0030384 87 60 2,000 8,497E-03 0,05940181 ! regulation of homeostatic process GO:0032844 105 60 2,000 8,497E-03 0,0592218 ! meiosis GO:0007126 96 61 2,000 8,892E-03 0,06178534 GO:0051327|M phase of meiotic cell cycle, ! homeostasis of number of cells GO:0048872 84 61 2,000 8,892E-03 0,06159924 ! extracellular matrix organization GO:0030198 103 61 2,000 8,892E-03 0,06141426 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 2,000 8,892E-03 0,06123039 ! negative regulation of cell growth GO:0030308 106 62 2,000 9,297E-03 0,06383004 ! respiratory tube development GO:0030323 99 62 2,000 9,297E-03 0,06364007 ! meiotic cell cycle GO:0051321 97 62 2,000 9,297E-03 0,06345123 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 9,301E-03 0,06329212 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 9,301E-03 0,06310542 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 1,000 9,301E-03 0,06291982 ! vesicle docking GO:0048278 27 21 1,000 9,301E-03 0,0627353 ! ovarian follicle development GO:0001541 30 21 1,000 9,301E-03 0,06255186 ! cell aging GO:0007569 32 21 1,000 9,301E-03 0,0623695 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 9,301E-03 0,06218819 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 9,301E-03 0,06200794 ! response to cytokine stimulus GO:0034097 47 21 1,000 9,301E-03 0,06182872 ! negative regulation of cell size GO:0045792 108 64 2,000 0,01013952 0,06720718 ! respiratory system development GO:0060541 100 64 2,000 0,01013952 0,06701405 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01018496 0,06712153 ! molting cycle process GO:0022404 40 22 1,000 0,01018496 0,06692975 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01018496 0,06673907 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 0,01018496 0,06654947 GO:0010810|regulation of cell-substrate adhesion, ! ureteric bud development GO:0001657 32 22 1,000 0,01018496 0,06636095 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01018496 0,06617349 ! protein tetramerization GO:0051262 39 22 1,000 0,01018496 0,06598708 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 0,01057689 0,06833383 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 0,01057689 0,06814242 ! regulation of Rho protein signal transduction GO:0035023 111 66 2,000 0,01102506 0,0708314 ! neuron fate commitment GO:0048663 32 23 1,000 0,01110446 0,07114275 ! embryonic pattern specification GO:0009880 31 23 1,000 0,01110446 0,07094513 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01110446 0,07074861 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01110446 0,07055317 ! osteoblast differentiation GO:0001649 40 23 1,000 0,01110446 0,07035881 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01110446 0,07016552 ! interaction with host GO:0051701 37 23 1,000 0,01110446 0,06997328 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01110446 0,0697821 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01110446 0,06959196 ! cell fate determination GO:0001709 45 23 1,000 0,01110446 0,06940285 ! liver development GO:0001889 40 23 1,000 0,01110446 0,06921476 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,01195399 0,0743086 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,01205914 0,07476015 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,01205914 0,07455918 ! response to toxin GO:0009636 38 24 1,000 0,01205914 0,07435929 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,01205914 0,07416047 ! response to metal ion GO:0010038 103 70 2,000 0,01292664 0,07928342 ! humoral immune response GO:0006959 86 70 2,000 0,01292664 0,07907256 ! regulation of catabolic process GO:0009894 106 70 2,000 0,01292664 0,07886282 ! protein amino acid alkylation GO:0008213 39 25 1,000 0,01304848 0,0793955 GO:0006479|protein amino acid methylation, ! male gonad development GO:0008584 33 25 1,000 0,01304848 0,07918602 ! response to estradiol stimulus GO:0032355 34 25 1,000 0,01304848 0,07897763 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01304848 0,07877034 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 1,000 0,01304848 0,07856414 GO:0032943|mononuclear cell proliferation, ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,01342946 0,08064689 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,01394332 0,08351465 ! post-embryonic development GO:0009791 42 26 1,000 0,01407196 0,08406625 ! membrane docking GO:0022406 39 27 1,000 0,01512906 0,09014725 ! inner ear morphogenesis GO:0042472 35 27 1,000 0,01512906 0,08991431 ! GPI anchor biosynthetic process GO:0006506 37 27 1,000 0,01512906 0,08968258 ! response to ionizing radiation GO:0010212 47 27 1,000 0,01512906 0,08945203 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01512906 0,08922267 ! response to inorganic substance GO:0010035 115 75 2,000 0,0155514 0,09147884 ! negative regulation of growth GO:0045926 123 75 2,000 0,0155514 0,09124548 ! regulation of ligase activity GO:0051340 114 75 2,000 0,0155514 0,0910133 ! regulation of protein transport GO:0051223 114 76 2,000 0,01610969 0,09404136 GO:0070201|regulation of establishment of protein localization, ! negative regulation of response to external stimulus GO:0032102 37 28 1,000 0,01621927 0,09444134 ! GPI anchor metabolic process GO:0006505 40 28 1,000 0,01621927 0,09420285 ! complement activation, classical pathway GO:0006958 36 28 1,000 0,01621927 0,09396556 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01621927 0,09372947 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01621927 0,09349456 ! mesoderm formation GO:0001707 46 28 1,000 0,01621927 0,09326082 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01621927 0,09302825 ! BMP signaling pathway GO:0030509 40 28 1,000 0,01621927 0,09279684 ! sex differentiation GO:0007548 105 77 2,000 0,01667915 0,0951912 ! one-carbon metabolic process GO:0006730 110 77 2,000 0,01667915 0,09495558 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,01734209 0,09848595 ! ovulation cycle process GO:0022602 41 29 1,000 0,01734209 0,09824338 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01734209 0,09800199 ! formation of primary germ layer GO:0001704 48 29 1,000 0,01734209 0,09776179 ! tissue homeostasis GO:0001894 42 29 1,000 0,01734209 0,09752276 GO:0048871|multicellular organismal homeostasis, ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 2,000 0,01845473 0,10352655 GO:0010498|proteasomal protein catabolic process, ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 0,01849701 0,10351127 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,01849701 0,10326003 ! ovulation cycle GO:0042698 43 30 1,000 0,01849701 0,10301001 ! adult locomotory behavior GO:0008344 47 30 1,000 0,01849701 0,10276119 ! response to heat GO:0009408 41 30 1,000 0,01849701 0,10251358 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,01968355 0,10882731 ! odontogenesis GO:0042476 50 31 1,000 0,01968355 0,10856633 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,01968355 0,1083066 ! mesoderm morphogenesis GO:0048332 49 31 1,000 0,01968355 0,10804811 ! metanephros development GO:0001656 58 31 1,000 0,01968355 0,10779086 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01968355 0,10753482 ! leukocyte chemotaxis GO:0030595 43 31 1,000 0,01968355 0,10728 GO:0060326|cell chemotaxis, ! regulation of muscle development GO:0048634 48 32 1,000 0,0209012 0,11364719 ! regulation of protein stability GO:0031647 48 32 1,000 0,0209012 0,11337915 ! cytokine production GO:0001816 44 32 1,000 0,0209012 0,11311238 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,0209012 0,11284686 ! regulation of defense response GO:0031347 117 84 2,000 0,02097947 0,11300416 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,02097947 0,11274013 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 0,0216388 0,11601222 ! phosphoinositide biosynthetic process GO:0046489 47 33 1,000 0,02214949 0,11847401 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,02214949 0,11819913 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 1,000 0,02214949 0,11792552 ! female gonad development GO:0008585 49 33 1,000 0,02214949 0,11765317 ! regulation of proteolysis GO:0030162 50 33 1,000 0,02214949 0,11738208 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,02214949 0,11711224 ! cytokinesis GO:0000910 52 33 1,000 0,02214949 0,11684363 ! cell cycle arrest GO:0007050 150 86 2,000 0,0223094 0,11741791 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,02299128 0,12073044 GO:0060538|skeletal muscle organ development, ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02342793 0,12274316 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02342793 0,12246419 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,02342793 0,1221865 ! female gamete generation GO:0007292 43 34 1,000 0,02342793 0,12191006 ! isoprenoid metabolic process GO:0006720 46 34 1,000 0,02342793 0,12163487 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,02342793 0,12136091 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,02368442 0,12241384 ! protein processing GO:0016485 114 88 2,000 0,02368442 0,12213937 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,02473606 0,12727726 ! pigment metabolic process GO:0042440 61 35 1,000 0,02473606 0,12699316 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,0260734 0,13356083 GO:0046660|female sex differentiation, ! glycerophospholipid metabolic process GO:0006650 130 92 2,000 0,02656961 0,13580021 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,02731903 0,13932097 ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,02731903 0,13901274 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 0,02743948 0,13931747 GO:0006956|complement activation, ! amino acid activation GO:0043038 52 37 1,000 0,02743948 0,1390106 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,02883386 0,14575358 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,02883386 0,14543394 ! mesenchymal cell development GO:0014031 64 38 1,000 0,02883386 0,1451157 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 0,02883386 0,14479886 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,02963461 0,14849586 ! protein maturation GO:0051604 129 96 2,000 0,02963461 0,14817304 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,03025607 0,15095219 ! chromatin remodeling GO:0006338 68 39 1,000 0,03025607 0,15062545 ! JNK cascade GO:0007254 54 39 1,000 0,03025607 0,15030013 ! developmental growth GO:0048589 62 39 1,000 0,03025607 0,14997621 ! response to calcium ion GO:0051592 58 40 1,000 0,03170566 0,15682372 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,03170566 0,15648718 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,03170566 0,15615209 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03170566 0,15581844 ! T cell differentiation GO:0030217 65 40 1,000 0,03170566 0,1554862 ! B cell differentiation GO:0030183 62 40 1,000 0,03170566 0,15515538 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,03170566 0,15482596 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,03170566 0,15449794 ! extracellular structure organization GO:0043062 156 99 2,000 0,03205087 0,15584988 ! regulation of translation GO:0006417 151 100 2,000 0,03287858 0,15953739 ! protein amino acid lipidation GO:0006497 62 41 1,000 0,0331822 0,1606717 ! glucose transport GO:0015758 52 41 1,000 0,0331822 0,16033416 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03441329 0,16593411 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03441329 0,16558697 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03441329 0,16524128 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03441329 0,16489703 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03441329 0,1645542 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03441329 0,16421281 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03441329 0,16387282 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03441329 0,16353424 ! sleep GO:0030431 11 5 0,000 0,03441329 0,16319706 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03441329 0,16286126 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03441329 0,16252684 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03441329 0,1621938 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03441329 0,16186211 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03441329 0,16153178 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03441329 0,1612028 ! tongue development GO:0043586 6 5 0,000 0,03441329 0,16087515 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03441329 0,16054883 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03441329 0,16022383 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03441329 0,15990015 ! cobalt ion transport GO:0006824 9 5 0,000 0,03441329 0,15957777 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03441329 0,15925669 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03441329 0,15893689 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03441329 0,15861838 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03441329 0,15830115 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03441329 0,15798517 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03441329 0,15767046 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03441329 0,157357 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03441329 0,15704479 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03441329 0,15673381 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03441329 0,15642406 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03441329 0,15611553 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03441329 0,15580821 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03441329 0,15550211 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03441329 0,1551972 ! malate metabolic process GO:0006108 7 5 0,000 0,03441329 0,15489349 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03441329 0,15459096 ! behavioral response to pain GO:0048266 7 5 0,000 0,03441329 0,15428962 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03441329 0,15398944 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03441329 0,15369043 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03441329 0,15339258 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03441329 0,15309589 ! mating behavior GO:0007617 6 5 0,000 0,03441329 0,15280033 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03441329 0,15250592 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03441329 0,15221264 ! rhythmic behavior GO:0007622 12 5 0,000 0,03441329 0,15192048 ! copulation GO:0007620 7 5 0,000 0,03441329 0,15162945 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03441329 0,15133953 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03441329 0,15105071 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03441329 0,150763 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03441329 0,15047637 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03441329 0,15019084 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03441329 0,14990639 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03441329 0,14962301 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03441329 0,1493407 ! response to protozoan GO:0001562 9 5 0,000 0,03441329 0,14905946 ! lymph vessel development GO:0001945 7 5 0,000 0,03441329 0,14877927 ! endochondral ossification GO:0001958 12 5 0,000 0,03441329 0,14850014 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03441329 0,14822205 ! parathyroid gland development GO:0060017 8 5 0,000 0,03441329 0,147945 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03441329 0,14766898 ! anagen GO:0042640 6 5 0,000 0,03441329 0,14739399 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03441329 0,14712002 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03441329 0,14684707 ! nuclear migration GO:0007097 10 5 0,000 0,03441329 0,14657513 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03441329 0,1463042 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03441329 0,14603427 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03441329 0,14576533 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03441329 0,14549738 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03441329 0,14523041 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03441329 0,14496442 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03441329 0,1446994 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03441329 0,14443535 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03441329 0,14417226 ! ovulation GO:0030728 6 5 0,000 0,03441329 0,14391013 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03441329 0,14364895 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03441329 0,14338872 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,03441329 0,14312943 ! response to pH GO:0009268 9 5 0,000 0,03441329 0,14287107 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03441329 0,14261364 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03441329 0,14235714 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03441329 0,14210157 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03441329 0,1418469 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03441329 0,14159315 ! polyol catabolic process GO:0046174 7 5 0,000 0,03441329 0,14134031 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03441329 0,14108836 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03441329 0,14083732 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03441329 0,14058716 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03441329 0,14033789 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03441329 0,14008951 ! urea metabolic process GO:0019627 6 5 0,000 0,03441329 0,139842 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03441329 0,13959537 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03441329 0,1393496 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03441329 0,1391047 ! neutrophil activation GO:0042119 5 5 0,000 0,03441329 0,13886065 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03441329 0,13861747 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03441329 0,13837513 ! response to food GO:0032094 5 5 0,000 0,03441329 0,13813363 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03441329 0,13789298 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03441329 0,13765317 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03441329 0,13741419 ! forebrain neuron development GO:0021884 7 5 0,000 0,03441329 0,13717604 ! melanosome organization GO:0032438 7 5 0,000 0,03441329 0,13693871 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03441329 0,1367022 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03441329 0,1364665 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03441329 0,13623162 GO:0009251|glucan catabolic process, ! nucleoside transport GO:0015858 6 5 0,000 0,03441329 0,13599755 ! nucleoside salvage GO:0043174 7 5 0,000 0,03441329 0,13576428 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03441329 0,1355318 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03441329 0,13530012 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03441329 0,13506924 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03441329 0,13483914 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03441329 0,13460982 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03441329 0,13438128 ! depyrimidination GO:0045008 8 5 0,000 0,03441329 0,13415351 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03441329 0,13392652 ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03441329 0,13370029 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03441329 0,13347483 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03441329 0,13325012 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03441329 0,13302617 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03441329 0,13280297 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03441329 0,13258052 ! monocyte differentiation GO:0030224 8 5 0,000 0,03441329 0,13235882 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03441329 0,13213785 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03441329 0,13191762 ! centrosome duplication GO:0051298 5 5 0,000 0,03441329 0,13169812 ! response to UV-C GO:0010225 6 5 0,000 0,03441329 0,13147936 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03441329 0,13126131 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03441329 0,13104399 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03441329 0,13082739 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03441329 0,13061151 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03441329 0,13039633 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03441329 0,13018186 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03441329 0,1299681 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03441329 0,12975504 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03441329 0,12954267 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03441329 0,129331 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03441329 0,12912002 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03441329 0,12890973 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03441329 0,12870012 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03441329 0,12849119 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03441329 0,12828294 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03441329 0,12807536 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03441329 0,12786845 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03441329 0,12766221 ! neural tube patterning GO:0021532 6 5 0,000 0,03441329 0,12745664 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03441329 0,12725172 ! histone demethylation GO:0016577 9 5 0,000 0,03441329 0,12704747 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03441329 0,12684387 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03441329 0,12664092 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03441329 0,12643861 ! enteric nervous system development GO:0048484 8 5 0,000 0,03441329 0,12623696 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03441329 0,12603594 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03441329 0,12583557 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03441329 0,12563583 ! transcription termination GO:0006353 8 5 0,000 0,03441329 0,12543672 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03441329 0,12523825 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03441329 0,1250404 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03441329 0,12484317 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03441329 0,12464657 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03441329 0,12445059 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03441329 0,12425522 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03441329 0,12406046 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03441329 0,12386631 ! apical protein localization GO:0045176 6 5 0,000 0,03441329 0,12367277 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03441329 0,12347983 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03441329 0,1232875 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03441329 0,12309576 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03441329 0,12290462 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03441329 0,12271407 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03441329 0,12252411 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03441329 0,12233473 ! glial cell migration GO:0008347 10 5 0,000 0,03441329 0,12214595 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03441329 0,12195774 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03441329 0,12177011 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03441329 0,12158306 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03441329 0,12139658 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03441329 0,12121068 ! neural plate development GO:0001840 6 5 0,000 0,03441329 0,12102534 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03441329 0,12084057 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03441329 0,12065636 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03441329 0,12047271 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03441329 0,12028962 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03441329 0,12010709 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03441329 0,11992511 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03441329 0,11974368 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03441329 0,1195628 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03441329 0,11938246 ! spindle assembly GO:0051225 5 5 0,000 0,03441329 0,11920267 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03441329 0,11902342 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03441329 0,1188447 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03441329 0,11866653 ! organ regeneration GO:0031100 7 5 0,000 0,03441329 0,11848888 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03441329 0,11831177 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03441329 0,11813518 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03441329 0,11795912 GO:0055081|anion homeostasis, ! mitochondrial transport GO:0006839 60 42 1,000 0,03468523 0,11871434 ! hexose transport GO:0008645 54 42 1,000 0,03468523 0,11853795 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,03468523 0,11836208 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,03468523 0,11818673 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,03621434 0,12321445 ! leukocyte migration GO:0050900 60 43 1,000 0,03621434 0,12303245 ! tRNA processing GO:0008033 49 43 1,000 0,03621434 0,12285099 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,03621434 0,12267006 ! glycolysis GO:0006096 53 44 1,000 0,03776907 0,12774833 ! regulation of action potential GO:0001508 71 44 1,000 0,03776907 0,12756074 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,03776907 0,1273737 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,03776907 0,12718721 ! positive regulation of defense response GO:0031349 59 45 1,000 0,03934901 0,13231394 ! lipoprotein biosynthetic process GO:0042158 67 45 1,000 0,03934901 0,13212078 ! cell recognition GO:0008037 58 45 1,000 0,03934901 0,13192818 ! cell maturation GO:0048469 60 45 1,000 0,03934901 0,13173615 ! histone modification GO:0016570 68 46 1,000 0,04095375 0,13690933 ! response to UV GO:0009411 75 46 1,000 0,04095375 0,13671062 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04115367 0,1371789 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04115367 0,13698038 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04115367 0,13678243 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04115367 0,13658505 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04115367 0,13638824 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04115367 0,136192 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04115367 0,13599632 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04115367 0,13580121 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04115367 0,13560665 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04115367 0,13541265 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04115367 0,1352192 ! prostate gland development GO:0030850 9 6 0,000 0,04115367 0,13502631 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04115367 0,13483396 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04115367 0,13464216 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04115367 0,13445091 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04115367 0,1342602 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04115367 0,13407003 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04115367 0,1338804 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04115367 0,1336913 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04115367 0,13350274 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04115367 0,13331471 ! neuron adhesion GO:0007158 9 6 0,000 0,04115367 0,1331272 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,04115367 0,13294023 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04115367 0,13275377 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04115367 0,13256784 ! signal peptide processing GO:0006465 8 6 0,000 0,04115367 0,13238243 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04115367 0,13219754 ! mRNA stabilization GO:0048255 15 6 0,000 0,04115367 0,13201317 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04115367 0,1318293 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04115367 0,13164595 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04115367 0,13146311 ! opsonization GO:0008228 8 6 0,000 0,04115367 0,13128078 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04115367 0,13109895 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04115367 0,13091762 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04115367 0,1307368 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04115367 0,13055647 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04115367 0,13037664 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04115367 0,13019731 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04115367 0,13001846 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04115367 0,12984011 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04115367 0,12966225 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04115367 0,12948487 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04115367 0,12930798 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04115367 0,12913157 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04115367 0,12895564 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04115367 0,12878019 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04115367 0,12860522 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04115367 0,12843072 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04115367 0,12825669 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04115367 0,12808314 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04115367 0,12791006 ! thymic T cell selection GO:0045061 12 6 0,000 0,04115367 0,12773744 ! protein lipoylation GO:0009249 10 6 0,000 0,04115367 0,12756528 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04115367 0,12739359 ! drug transport GO:0015893 6 6 0,000 0,04115367 0,12722237 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04115367 0,1270516 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04115367 0,12688129 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04115367 0,12671143 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04115367 0,12654203 ! histidine metabolic process GO:0006547 6 6 0,000 0,04115367 0,12637309 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04115367 0,12620459 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04115367 0,12603654 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 0,04115367 0,12586894 ! adenohypophysis development GO:0021984 10 6 0,000 0,04115367 0,12570178 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04115367 0,12553507 ! hyperosmotic response GO:0006972 8 6 0,000 0,04115367 0,1253688 ! microtubule nucleation GO:0007020 10 6 0,000 0,04115367 0,12520296 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04115367 0,12503757 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04115367 0,12487261 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04115367 0,12470809 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04115367 0,124544 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04115367 0,12438034 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04115367 0,12421711 ! response to dietary excess GO:0002021 7 6 0,000 0,04115367 0,12405431 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04115367 0,12389194 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04115367 0,12372999 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04115367 0,12356846 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04115367 0,12340735 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04115367 0,12324667 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04115367 0,1230864 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04115367 0,12292655 ! neuron apoptosis GO:0051402 8 6 0,000 0,04115367 0,12276711 ! organic alcohol transport GO:0015850 9 6 0,000 0,04115367 0,12260808 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04115367 0,12244947 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04115367 0,12229127 ! carnitine transport GO:0015879 8 6 0,000 0,04115367 0,12213347 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04115367 0,12197608 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04115367 0,1218191 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04115367 0,12166252 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04115367 0,12150634 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04115367 0,12135057 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04115367 0,12119519 ! parturition GO:0007567 12 6 0,000 0,04115367 0,12104021 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04115367 0,12088562 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04115367 0,12073143 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04115367 0,12057763 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04115367 0,12042423 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04115367 0,12027121 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04115367 0,12011858 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04115367 0,11996634 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04115367 0,11981448 ! macrophage differentiation GO:0030225 10 6 0,000 0,04115367 0,11966301 ! astrocyte development GO:0014002 14 6 0,000 0,04115367 0,11951192 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04115367 0,11936121 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04115367 0,11921088 ! interaction with symbiont GO:0051702 8 6 0,000 0,04115367 0,11906093 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04115367 0,11891136 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04115367 0,11876216 ! eating behavior GO:0042755 6 6 0,000 0,04115367 0,11861333 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04115367 0,11846488 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04115367 0,1183168 ! response to copper ion GO:0046688 9 6 0,000 0,04115367 0,11816909 ! DNA topological change GO:0006265 8 6 0,000 0,04115367 0,11802175 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04115367 0,11787477 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04115367 0,11772816 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04115367 0,11758191 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04115367 0,11743603 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04115367 0,11729051 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04115367 0,11714535 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04115367 0,11700054 ! hair follicle maturation GO:0048820 7 6 0,000 0,04115367 0,1168561 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04115367 0,11671201 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04115367 0,11656828 ! Schwann cell development GO:0014044 14 6 0,000 0,04115367 0,1164249 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04115367 0,11628187 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04115367 0,11613919 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04115367 0,11599686 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04115367 0,11585488 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04115367 0,11571325 ! histone ubiquitination GO:0016574 7 6 0,000 0,04115367 0,11557197 ! regulation of meiosis GO:0040020 10 6 0,000 0,04115367 0,11543103 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04115367 0,11529043 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04115367 0,11515017 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04115367 0,11501026 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04115367 0,11487068 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04115367 0,11473144 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04115367 0,11459254 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04115367 0,11445398 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04115367 0,11431575 ! receptor internalization GO:0031623 9 6 0,000 0,04115367 0,11417785 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04115367 0,11404029 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04115367 0,11390306 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04115367 0,11376615 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04115367 0,11362958 ! protein deubiquitination GO:0016579 8 6 0,000 0,04115367 0,11349333 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04115367 0,11335741 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,04115367 0,11322182 ! axonal fasciculation GO:0007413 9 6 0,000 0,04115367 0,11308655 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04115367 0,1129516 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04115367 0,11281697 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04115367 0,11268267 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04115367 0,11254868 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04115367 0,11241501 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04115367 0,11228166 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04115367 0,11214863 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04115367 0,11201591 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04115367 0,1118835 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04115367 0,11175141 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04115367 0,11161962 ! adult feeding behavior GO:0008343 6 6 0,000 0,04115367 0,11148815 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04115367 0,11135699 ! blastocyst growth GO:0001832 15 6 0,000 0,04115367 0,11122614 ! pigment granule transport GO:0051904 12 6 0,000 0,04115367 0,11109559 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04115367 0,11096535 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04115367 0,11083541 ! catecholamine transport GO:0051937 7 6 0,000 0,04115367 0,11070578 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04115367 0,11057645 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04115367 0,11044742 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04115367 0,1103187 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,04115367 0,11019027 ! protein prenylation GO:0018342 10 6 0,000 0,04115367 0,11006214 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04115367 0,10993431 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04115367 0,10980678 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04115367 0,10967954 ! covalent chromatin modification GO:0016569 75 47 1,000 0,04258285 0,11335712 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,04258285 0,11322607 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,04258285 0,11309533 ! response to temperature stimulus GO:0009266 62 48 1,000 0,04423591 0,11735017 ! gastrulation GO:0007369 73 48 1,000 0,04423591 0,11721497 ! heart morphogenesis GO:0003007 65 48 1,000 0,04423591 0,11708009 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,04423591 0,11694551 GO:0019724|B cell mediated immunity, ! regulation of endocytosis GO:0030100 63 48 1,000 0,04423591 0,11681125 ! nuclear export GO:0051168 69 48 1,000 0,04423591 0,11667729 ! RNA elongation GO:0006354 62 49 1,000 0,04591252 0,12096083 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,04591252 0,12082243 ! germ cell development GO:0007281 68 49 1,000 0,04591252 0,12068435 ! maintenance of location GO:0051235 84 49 1,000 0,04591252 0,12054658 ! lipid modification GO:0030258 73 50 1,000 0,04761228 0,12486688 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,04784738 0,12534051 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04784738 0,12519792 GO:0016446|somatic hypermutation of immunoglobulin genes, ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04784738 0,12505565 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04784738 0,1249137 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04784738 0,12477208 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04784738 0,12463077 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04784738 0,12448979 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04784738 0,12434912 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04784738 0,12420877 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04784738 0,12406874 ! reproductive behavior GO:0019098 12 7 0,000 0,04784738 0,12392902 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04784738 0,12378962 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04784738 0,12365053 ! oligopeptide transport GO:0006857 11 7 0,000 0,04784738 0,12351175 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04784738 0,12337329 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04784738 0,12323513 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,04784738 0,12309728 ! pericardium development GO:0060039 8 7 0,000 0,04784738 0,12295974 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04784738 0,12282251 ! fibril organization GO:0043206 13 7 0,000 0,04784738 0,12268559 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04784738 0,12254897 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04784738 0,12241265 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04784738 0,12227663 ! lipoprotein transport GO:0042953 9 7 0,000 0,04784738 0,12214092 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04784738 0,12200551 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04784738 0,1218704 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04784738 0,12173559 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04784738 0,12160107 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04784738 0,12146686 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04784738 0,12133293 ! chemosensory behavior GO:0007635 9 7 0,000 0,04784738 0,12119931 ! microtubule bundle formation GO:0001578 8 7 0,000 0,04784738 0,12106597 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,04784738 0,12093293 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04784738 0,12080019 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04784738 0,12066773 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04784738 0,12053556 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04784738 0,12040369 ! reflex GO:0060004 12 7 0,000 0,04784738 0,1202721 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04784738 0,1201408 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04784738 0,12000978 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04784738 0,11987905 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04784738 0,11974861 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04784738 0,11961845 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04784738 0,11948857 ! spinal cord patterning GO:0021511 7 7 0,000 0,04784738 0,11935897 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04784738 0,11922965 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04784738 0,11910062 ! adrenal gland development GO:0030325 17 7 0,000 0,04784738 0,11897186 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04784738 0,11884338 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04784738 0,11871518 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04784738 0,11858725 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04784738 0,1184596 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04784738 0,11833223 ! endosome organization GO:0007032 10 7 0,000 0,04784738 0,11820512 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04784738 0,11807829 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04784738 0,11795174 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04784738 0,11782545 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04784738 0,11769943 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04784738 0,11757369 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04784738 0,11744821 ! galactose metabolic process GO:0006012 10 7 0,000 0,04784738 0,117323 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04784738 0,11719805 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04784738 0,11707337 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04784738 0,11694896 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04784738 0,11682481 ! retinol metabolic process GO:0042572 9 7 0,000 0,04784738 0,11670092 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04784738 0,1165773 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04784738 0,11645394 ! rRNA modification GO:0000154 12 7 0,000 0,04784738 0,11633084 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04784738 0,11620799 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,04784738 0,11608541 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04784738 0,11596309 ! intermediate filament organization GO:0045109 11 7 0,000 0,04784738 0,11584102 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04784738 0,11571921 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04784738 0,11559766 ! fibrinolysis GO:0042730 9 7 0,000 0,04784738 0,11547636 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04784738 0,11535532 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04784738 0,11523452 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04784738 0,11511399 ! response to tropane GO:0014073 13 7 0,000 0,04784738 0,1149937 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04784738 0,11487366 ! melanosome localization GO:0032400 10 7 0,000 0,04784738 0,11475388 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04784738 0,11463434 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04784738 0,11451506 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04784738 0,11439602 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04784738 0,11427723 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04784738 0,11415868 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04784738 0,11404038 ! mast cell activation GO:0045576 9 7 0,000 0,04784738 0,11392233 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04784738 0,11380452 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04784738 0,11368695 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04784738 0,11356963 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04784738 0,11345255 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04784738 0,11333571 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04784738 0,11321911 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04784738 0,11310274 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04784738 0,11298662 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04784738 0,11287074 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04784738 0,11275509 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04784738 0,11263968 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04784738 0,11252451 ! response to tumor cell GO:0002347 12 7 0,000 0,04784738 0,11240957 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04784738 0,11229487 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04784738 0,1121804 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04784738 0,11206616 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04784738 0,11195216 ! diuresis GO:0030146 12 7 0,000 0,04784738 0,11183838 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04784738 0,11172484 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04784738 0,11161153 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04784738 0,11149845 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04784738 0,1113856 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04784738 0,11127297 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04784738 0,11116058 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04784738 0,11104841 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04784738 0,11093646 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04784738 0,11082474 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04784738 0,11071325 ! lymph node development GO:0048535 9 7 0,000 0,04784738 0,11060198 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04784738 0,11049093 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04784738 0,11038011 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04784738 0,11026951 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04784738 0,11015913 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04784738 0,11004897 ! ATP catabolic process GO:0006200 10 7 0,000 0,04784738 0,10993903 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04784738 0,10982931 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04784738 0,10971981 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04784738 0,10961053 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04784738 0,10950146 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04784738 0,10939262 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04784738 0,10928398 ! muscle adaptation GO:0043500 12 7 0,000 0,04784738 0,10917557 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04784738 0,10906736 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04784738 0,10895938 ! retina homeostasis GO:0001895 9 7 0,000 0,04784738 0,1088516 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04784738 0,10874404 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04784738 0,10863669 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04784738 0,10852956 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04784738 0,10842263 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04784738 0,10831592 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04784738 0,10820941 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04784738 0,10810311 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,0493348 0,1113543 ! adult behavior GO:0030534 80 51 1,000 0,0493348 0,11124513 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,0493348 0,11113617 ! aging GO:0007568 79 52 1,000 0,05107966 0,11495423 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,05107966 0,11484186 ! establishment of organelle localization GO:0051656 85 52 1,000 0,05107966 0,11472971 ! glycerophospholipid biosynthetic process GO:0046474 75 53 1,000 0,05284649 0,11858237 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,05284649 0,11846679 ! kidney development GO:0001822 90 53 1,000 0,05284649 0,11835144 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05449474 0,12192403 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05449474 0,12180554 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,05449474 0,12168728 ! axon extension GO:0048675 11 8 0,000 0,05449474 0,12156925 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,05449474 0,12145145 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05449474 0,12133388 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05449474 0,12121654 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05449474 0,12109942 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05449474 0,12098253 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05449474 0,12086586 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,05449474 0,12074942 ! phosphate transport GO:0006817 10 8 0,000 0,05449474 0,1206332 ! N-glycan processing GO:0006491 12 8 0,000 0,05449474 0,12051721 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05449474 0,12040144 ! UTP metabolic process GO:0046051 8 8 0,000 0,05449474 0,12028589 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05449474 0,12017056 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05449474 0,12005546 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,05449474 0,11994057 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05449474 0,11982591 ! succinate metabolic process GO:0006105 14 8 0,000 0,05449474 0,11971146 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05449474 0,11959723 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05449474 0,11948322 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05449474 0,11936943 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05449474 0,11925585 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05449474 0,11914249 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05449474 0,11902934 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05449474 0,11891641 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05449474 0,1188037 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05449474 0,11869119 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05449474 0,1185789 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05449474 0,11846682 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05449474 0,11835496 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05449474 0,1182433 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05449474 0,11813186 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05449474 0,11802062 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05449474 0,11790959 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05449474 0,11779878 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05449474 0,11768817 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05449474 0,11757777 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05449474 0,11746757 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05449474 0,11735758 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,05449474 0,1172478 ! macrophage activation GO:0042116 12 8 0,000 0,05449474 0,11713822 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05449474 0,11702885 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05449474 0,11691968 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,05449474 0,11681072 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05449474 0,11670195 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05449474 0,11659339 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05449474 0,11648504 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05449474 0,11637688 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05449474 0,11626892 ! ruffle organization GO:0031529 11 8 0,000 0,05449474 0,11616117 ! osteoblast development GO:0002076 13 8 0,000 0,05449474 0,11605361 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05449474 0,11594625 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05449474 0,11583909 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05449474 0,11573213 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05449474 0,11562537 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05449474 0,1155188 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05449474 0,11541243 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05449474 0,11530626 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05449474 0,11520028 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05449474 0,11509449 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,05449474 0,1149889 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,05449474 0,1148835 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05449474 0,1147783 ! segment specification GO:0007379 10 8 0,000 0,05449474 0,11467328 ! cellular extravasation GO:0045123 11 8 0,000 0,05449474 0,11456846 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05449474 0,11446383 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05449474 0,1143594 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05449474 0,11425515 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,05449474 0,11415109 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05449474 0,11404722 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05449474 0,11394354 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05449474 0,11384005 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05449474 0,11373675 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05449474 0,11363363 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05449474 0,11353071 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05449474 0,11342796 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05449474 0,11332541 ! icosanoid secretion GO:0032309 12 8 0,000 0,05449474 0,11322303 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05449474 0,11312085 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05449474 0,11301885 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05449474 0,11291703 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05449474 0,11281539 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05449474 0,11271394 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05449474 0,11261267 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05449474 0,11251158 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05449474 0,11241067 ! sterol catabolic process GO:0016127 9 8 0,000 0,05449474 0,11230995 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05449474 0,1122094 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05449474 0,11210903 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05449474 0,11200885 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05449474 0,11190884 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05449474 0,11180901 ! prophase GO:0051324 11 8 0,000 0,05449474 0,11170936 ! S phase GO:0051320 8 8 0,000 0,05449474 0,11160988 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05449474 0,11151059 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05449474 0,11141147 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05449474 0,11131252 ! hormone catabolic process GO:0042447 13 8 0,000 0,05449474 0,11121375 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05449474 0,11111516 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05449474 0,11101674 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05449474 0,11091849 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05449474 0,11082042 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05449474 0,11072253 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05449474 0,1106248 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05449474 0,11052725 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05449474 0,11042987 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05449474 0,11033266 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05449474 0,11023562 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05449474 0,11013875 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05449474 0,11004205 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05449474 0,10994553 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,05449474 0,10984917 ! glucose catabolic process GO:0006007 66 54 1,000 0,0546349 0,11003526 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,0546349 0,10993899 ! detection of external stimulus GO:0009581 66 54 1,000 0,0546349 0,10984289 ! cellular amino acid catabolic process GO:0009063 74 54 1,000 0,0546349 0,10974696 ! mesoderm development GO:0007498 76 55 1,000 0,0564445 0,11328304 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,05827493 0,1168547 ! carbohydrate transport GO:0008643 74 57 1,000 0,0601258 0,1204611 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,0601258 0,12035626 GO:0048609|reproductive process in a multicellular organism, ! secondary metabolic process GO:0019748 84 57 1,000 0,0601258 0,1202516 ! developmental maturation GO:0021700 75 57 1,000 0,0601258 0,12014713 ! gonad development GO:0008406 79 57 1,000 0,0601258 0,12004283 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06109607 0,12187421 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06109607 0,12176859 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06109607 0,12166317 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06109607 0,12155792 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06109607 0,12145286 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06109607 0,12134798 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06109607 0,12124328 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06109607 0,12113876 ! GTP metabolic process GO:0046039 9 9 0,000 0,06109607 0,12103442 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06109607 0,12093026 ! social behavior GO:0035176 14 9 0,000 0,06109607 0,12082628 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06109607 0,12072247 ! artery development GO:0060840 19 9 0,000 0,06109607 0,12061885 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06109607 0,1205154 ! response to pain GO:0048265 16 9 0,000 0,06109607 0,12041213 ! protein complex disassembly GO:0043241 17 9 0,000 0,06109607 0,12030904 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06109607 0,12020612 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06109607 0,12010338 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06109607 0,12000082 ! lung alveolus development GO:0048286 17 9 0,000 0,06109607 0,11989843 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06109607 0,11979621 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06109607 0,11969417 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06109607 0,11959231 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06109607 0,11949061 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06109607 0,11938909 ! protein targeting to ER GO:0045047 19 9 0,000 0,06109607 0,11928774 ! endoderm development GO:0007492 12 9 0,000 0,06109607 0,11918656 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06109607 0,11908556 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06109607 0,11898472 ! arginine catabolic process GO:0006527 10 9 0,000 0,06109607 0,11888406 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06109607 0,11878357 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06109607 0,11868324 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06109607 0,11858309 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06109607 0,1184831 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,06109607 0,11838328 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06109607 0,11828364 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06109607 0,11818415 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06109607 0,11808484 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06109607 0,11798569 ! mannose metabolic process GO:0006013 9 9 0,000 0,06109607 0,11788671 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06109607 0,11778789 ! receptor clustering GO:0043113 15 9 0,000 0,06109607 0,11768924 ! epithelial cell development GO:0002064 10 9 0,000 0,06109607 0,11759076 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06109607 0,11749244 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06109607 0,11739428 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06109607 0,11729629 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06109607 0,11719846 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06109607 0,1171008 ! motor axon guidance GO:0008045 14 9 0,000 0,06109607 0,1170033 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06109607 0,11690596 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06109607 0,11680878 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06109607 0,11671176 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06109607 0,1166149 ! DNA ligation GO:0006266 14 9 0,000 0,06109607 0,11651821 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06109607 0,11642167 ! response to amine stimulus GO:0014075 13 9 0,000 0,06109607 0,1163253 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06109607 0,11622908 ! erythrocyte development GO:0048821 11 9 0,000 0,06109607 0,11613302 ! renal water homeostasis GO:0003091 14 9 0,000 0,06109607 0,11603713 ! postreplication repair GO:0006301 11 9 0,000 0,06109607 0,11594138 ! mRNA cleavage GO:0006379 13 9 0,000 0,06109607 0,1158458 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06109607 0,11575038 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06109607 0,11565511 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06109607 0,11556 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06109607 0,11546504 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06109607 0,11537025 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06109607 0,1152756 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06109607 0,11518111 ! acid secretion GO:0046717 14 9 0,000 0,06109607 0,11508678 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06109607 0,1149926 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06109607 0,11489858 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06109607 0,1148047 ! purine base metabolic process GO:0006144 18 9 0,000 0,06109607 0,11471099 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06109607 0,11461742 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06109607 0,11452401 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06109607 0,11443075 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06109607 0,11433764 ! detection of calcium ion GO:0005513 13 9 0,000 0,06109607 0,11424468 ! blastocyst formation GO:0001825 12 9 0,000 0,06109607 0,11415188 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06109607 0,11405922 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06109607 0,11396671 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06109607 0,11387436 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06109607 0,11378215 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06109607 0,1136901 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06109607 0,11359819 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06109607 0,11350643 ! prepulse inhibition GO:0060134 14 9 0,000 0,06109607 0,11341482 ! embryonic placenta development GO:0001892 12 9 0,000 0,06109607 0,11332335 ! insulin secretion GO:0030073 17 9 0,000 0,06109607 0,11323204 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06109607 0,11314087 ! nucleus localization GO:0051647 15 9 0,000 0,06109607 0,11304985 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06109607 0,11295897 ! localization within membrane GO:0051668 15 9 0,000 0,06109607 0,11286824 ! viral reproductive process GO:0022415 87 58 1,000 0,06199675 0,11444023 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,06199675 0,11434846 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,06199675 0,11425683 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,06199675 0,11416535 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,06388741 0,11755284 ! activation of MAPK activity GO:0000187 84 59 1,000 0,06388741 0,11745887 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,06388741 0,11736505 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,06579742 0,1207774 ! glycerolipid biosynthetic process GO:0045017 85 60 1,000 0,06579742 0,12068108 ! regulation of heart contraction GO:0008016 91 60 1,000 0,06579742 0,12058492 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,06579742 0,12048891 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,06765168 0,1237859 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06765168 0,1236875 ! neuron fate specification GO:0048665 11 10 0,000 0,06765168 0,12358926 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,06765168 0,12349117 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,06765168 0,12339324 ! thyroid gland development GO:0030878 19 10 0,000 0,06765168 0,12329546 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,06765168 0,12319784 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,06765168 0,12310038 ! synapsis GO:0007129 13 10 0,000 0,06765168 0,12300306 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06765168 0,1229059 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,06765168 0,1228089 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06765168 0,12271205 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,06765168 0,12261535 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06765168 0,1225188 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,06765168 0,1224224 ! androgen metabolic process GO:0008209 13 10 0,000 0,06765168 0,12232616 ! phospholipid efflux GO:0033700 16 10 0,000 0,06765168 0,12223007 ! hippocampus development GO:0021766 19 10 0,000 0,06765168 0,12213413 ! blood vessel remodeling GO:0001974 21 10 0,000 0,06765168 0,12203833 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,06765168 0,12194269 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06765168 0,1218472 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,06765168 0,12175186 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,06765168 0,12165667 ! pathogenesis GO:0009405 13 10 0,000 0,06765168 0,12156162 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06765168 0,12146673 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06765168 0,12137198 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06765168 0,12127738 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,06765168 0,12118292 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,06765168 0,12108862 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06765168 0,12099446 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06765168 0,12090045 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,06765168 0,12080658 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06765168 0,12071286 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06765168 0,12061928 ! response to X-ray GO:0010165 16 10 0,000 0,06765168 0,12052585 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,06765168 0,12043257 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,06765168 0,12033942 ! forebrain cell migration GO:0021885 17 10 0,000 0,06765168 0,12024643 ! lipid digestion GO:0044241 15 10 0,000 0,06765168 0,12015357 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06765168 0,12006086 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,06765168 0,11996829 ! UV protection GO:0009650 14 10 0,000 0,06765168 0,11987587 ! entry into host cell GO:0030260 20 10 0,000 0,06765168 0,11978358 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06765168 0,11969144 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,06765168 0,11959944 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,06765168 0,11950758 ! regulation of bone resorption GO:0045124 24 10 0,000 0,06765168 0,11941587 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06765168 0,11932429 ! regulation of organ growth GO:0046620 11 10 0,000 0,06765168 0,11923285 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06765168 0,11914156 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06765168 0,1190504 ! embryonic axis specification GO:0000578 12 10 0,000 0,06765168 0,11895938 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,06765168 0,11886851 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,06765168 0,11877777 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,06765168 0,11868717 ! cranial nerve development GO:0021545 12 10 0,000 0,06765168 0,1185967 ! fucose catabolic process GO:0019317 16 10 0,000 0,06765168 0,11850638 GO:0042355|L-fucose catabolic process, ! protein sumoylation GO:0016925 12 10 0,000 0,06765168 0,11841619 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06765168 0,11832614 ! zymogen activation GO:0031638 14 10 0,000 0,06765168 0,11823623 ! salivary gland development GO:0007431 22 10 0,000 0,06765168 0,11814645 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06765168 0,11805681 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,06765168 0,11796731 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,06765168 0,11787794 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06765168 0,1177887 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,06765168 0,1176996 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,06765168 0,11761064 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06765168 0,11752181 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06765168 0,11743311 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06765168 0,11734455 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06765168 0,11725612 ! detection of bacterium GO:0016045 10 10 0,000 0,06765168 0,11716783 ! embryonic gut development GO:0048566 11 10 0,000 0,06765168 0,11707967 ! activation of innate immune response GO:0002218 10 10 0,000 0,06765168 0,11699164 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,06765168 0,11690374 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,06765168 0,11681597 ! developmental induction GO:0031128 13 10 0,000 0,06765168 0,11672834 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,06765168 0,11664084 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,06765168 0,11655346 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06765168 0,11646622 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,06765168 0,11637911 ! lipoprotein metabolic process GO:0042157 89 61 1,000 0,06772643 0,11642062 ! urogenital system development GO:0001655 101 61 1,000 0,06772643 0,11633368 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,06772643 0,11624686 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 1,000 0,06967408 0,11950066 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,06967408 0,11941161 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,06967408 0,1193227 ! organelle localization GO:0051640 96 62 1,000 0,06967408 0,11923392 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,07164002 0,1225071 ! viral reproduction GO:0016032 92 63 1,000 0,07164002 0,12241608 ! hexose catabolic process GO:0019320 82 64 1,000 0,07362391 0,12571269 ! adaptive immune response GO:0002250 94 64 1,000 0,07362391 0,12561943 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! respiratory burst GO:0045730 14 11 0,000 0,0741619 0,12644357 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,0741619 0,12634991 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,0741619 0,12625638 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,0741619 0,126163 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,0741619 0,12606975 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,0741619 0,12597664 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,0741619 0,12588367 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,0741619 0,12579084 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,0741619 0,12569814 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,0741619 0,12560558 ! T cell proliferation GO:0042098 20 11 0,000 0,0741619 0,12551315 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,0741619 0,12542086 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,0741619 0,12532871 ! bone resorption GO:0045453 16 11 0,000 0,0741619 0,12523669 ! regulated secretory pathway GO:0045055 14 11 0,000 0,0741619 0,12514481 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,0741619 0,12505306 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,0741619 0,12496144 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,0741619 0,12486997 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,0741619 0,12477862 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,0741619 0,12468741 ! syncytium formation GO:0006949 15 11 0,000 0,0741619 0,12459633 ! plasma membrane organization GO:0007009 18 11 0,000 0,0741619 0,12450538 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,0741619 0,12441457 ! mitotic spindle organization GO:0007052 15 11 0,000 0,0741619 0,12432389 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,0741619 0,12423334 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,0741619 0,12414292 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,0741619 0,12405263 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,0741619 0,12396248 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,0741619 0,12387246 ! temperature homeostasis GO:0001659 16 11 0,000 0,0741619 0,12378256 ! L-glutamate transport GO:0015813 16 11 0,000 0,0741619 0,1236928 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,0741619 0,12360317 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,0741619 0,12351367 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,0741619 0,12342429 ! stem cell development GO:0048864 29 11 0,000 0,0741619 0,12333505 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,0741619 0,12324593 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,0741619 0,12315695 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,0741619 0,12306809 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,0741619 0,12297936 ! vasoconstriction GO:0042310 15 11 0,000 0,0741619 0,12289076 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,0741619 0,12280228 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,0741619 0,12271394 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,0741619 0,12262572 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,0741619 0,12253762 ! ribosome assembly GO:0042255 13 11 0,000 0,0741619 0,12244966 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,0741619 0,12236182 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,0741619 0,1222741 ! chromatin silencing GO:0006342 19 11 0,000 0,0741619 0,12218651 ! nucleosome positioning GO:0016584 13 11 0,000 0,0741619 0,12209905 ! regulation of isotype switching GO:0045191 19 11 0,000 0,0741619 0,12201171 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,0741619 0,1219245 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,0741619 0,12183741 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,0741619 0,12175044 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,0741619 0,1216636 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,0741619 0,12157689 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,0741619 0,12149029 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,0741619 0,12140382 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,0741619 0,12131748 ! cholesterol efflux GO:0033344 19 11 0,000 0,0741619 0,12123125 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,0741619 0,12114515 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,0741619 0,12105917 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,0741619 0,12097331 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,0741619 0,12088758 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,0741619 0,12080196 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,0741619 0,12071647 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,0741619 0,1206311 ! lysogeny GO:0030069 18 11 0,000 0,0741619 0,12054585 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,0741619 0,12046071 ! acrosome reaction GO:0007340 13 11 0,000 0,0741619 0,1203757 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,0741619 0,12029081 ! reproductive structure development GO:0048608 90 65 1,000 0,0756254 0,12257817 ! B cell activation GO:0042113 104 65 1,000 0,0756254 0,12249185 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,0756254 0,12240564 ! activation of immune response GO:0002253 83 65 1,000 0,0756254 0,12231956 ! axon guidance GO:0007411 99 66 1,000 0,07764416 0,12549654 ! lactation GO:0007595 20 12 0,000 0,08062703 0,13022624 ! reproductive cellular process GO:0048610 14 12 0,000 0,08062703 0,13013485 ! tRNA modification GO:0006400 14 12 0,000 0,08062703 0,13004359 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08062703 0,12995246 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08062703 0,12986146 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08062703 0,12977059 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08062703 0,12967984 ! non-recombinational repair GO:0000726 19 12 0,000 0,08062703 0,12958921 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08062703 0,12949872 ! peroxisomal transport GO:0043574 21 12 0,000 0,08062703 0,12940835 ! cartilage condensation GO:0001502 18 12 0,000 0,08062703 0,12931811 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,08062703 0,12922799 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08062703 0,129138 ! heart looping GO:0001947 15 12 0,000 0,08062703 0,12904813 ! palate development GO:0060021 15 12 0,000 0,08062703 0,12895839 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08062703 0,12886877 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08062703 0,12877928 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08062703 0,12868991 ! arginine metabolic process GO:0006525 13 12 0,000 0,08062703 0,12860067 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08062703 0,12851155 ! methionine metabolic process GO:0006555 13 12 0,000 0,08062703 0,12842255 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08062703 0,12833368 ! Golgi organization GO:0007030 18 12 0,000 0,08062703 0,12824493 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08062703 0,1281563 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08062703 0,12806779 ! monoamine transport GO:0015844 13 12 0,000 0,08062703 0,12797941 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08062703 0,12789115 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08062703 0,12780301 ! L-amino acid transport GO:0015807 20 12 0,000 0,08062703 0,12771499 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08062703 0,12762709 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08062703 0,12753932 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08062703 0,12745166 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08062703 0,12736413 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08062703 0,12727671 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08062703 0,12718941 ! cerebellum development GO:0021549 13 12 0,000 0,08062703 0,12710224 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08062703 0,12701518 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08062703 0,12692825 ! histone acetylation GO:0016573 23 12 0,000 0,08062703 0,12684143 ! autonomic nervous system development GO:0048483 23 12 0,000 0,08062703 0,12675473 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08062703 0,12666815 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,08062703 0,12658168 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08062703 0,12649534 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08062703 0,12640911 ! intestinal absorption GO:0050892 19 12 0,000 0,08062703 0,126323 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08062703 0,12623701 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08062703 0,12615113 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08062703 0,12606537 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08062703 0,12597973 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,08062703 0,12589421 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08062703 0,1258088 ! microspike assembly GO:0030035 23 12 0,000 0,08062703 0,1257235 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08062703 0,12563832 ! response to cold GO:0009409 14 12 0,000 0,08062703 0,12555326 ! acute inflammatory response GO:0002526 92 68 1,000 0,08173215 0,12718806 ! rhythmic process GO:0048511 105 68 1,000 0,08173215 0,12710207 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,08380073 0,13023087 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,08588526 0,13338022 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,08588526 0,13329022 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,08704738 0,13500268 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,08704738 0,1349117 ! cGMP metabolic process GO:0046068 16 13 0,000 0,08704738 0,13482086 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,08704738 0,13473013 ! water transport GO:0006833 17 13 0,000 0,08704738 0,13463952 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,08704738 0,13454904 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,08704738 0,13445868 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,08704738 0,13436844 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,08704738 0,13427832 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,08704738 0,13418832 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,08704738 0,13409844 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,08704738 0,13400868 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,08704738 0,13391904 ! response to hexose stimulus GO:0009746 19 13 0,000 0,08704738 0,13382953 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,08704738 0,13374013 ! glutamate metabolic process GO:0006536 18 13 0,000 0,08704738 0,13365085 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,08704738 0,13356169 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,08704738 0,13347265 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,08704738 0,13338372 ! NAD metabolic process GO:0019674 21 13 0,000 0,08704738 0,13329492 ! exocrine system development GO:0035272 27 13 0,000 0,08704738 0,13320623 ! bone mineralization GO:0030282 15 13 0,000 0,08704738 0,13311767 ! regulation of exocytosis GO:0017157 17 13 0,000 0,08704738 0,13302922 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,08704738 0,13294088 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,08704738 0,13285267 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,08704738 0,13276457 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,08704738 0,13267659 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,08704738 0,13258872 ! regulation of cellular pH GO:0030641 20 13 0,000 0,08704738 0,13250097 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,08704738 0,13241334 ! tissue regeneration GO:0042246 21 13 0,000 0,08704738 0,13232582 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,08704738 0,13223842 ! cofactor transport GO:0051181 19 13 0,000 0,08704738 0,13215114 ! NADP metabolic process GO:0006739 18 13 0,000 0,08704738 0,13206396 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,08704738 0,13197691 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,08704738 0,13188997 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08704738 0,13180314 ! gas transport GO:0015669 18 13 0,000 0,08704738 0,13171643 ! heme biosynthetic process GO:0006783 20 13 0,000 0,08704738 0,13162983 ! regulation of axon extension GO:0030516 23 13 0,000 0,08704738 0,13154334 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,08704738 0,13145697 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,08704738 0,13137072 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,08704738 0,13128457 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,08704738 0,13119854 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,08704738 0,13111262 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,08798543 0,1324388 ! muscle cell differentiation GO:0042692 104 71 1,000 0,08798543 0,13235219 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,08798543 0,13226568 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,08798543 0,13217929 ! monosaccharide catabolic process GO:0046365 91 71 1,000 0,08798543 0,13209301 ! negative regulation of transport GO:0051051 116 73 1,000 0,09223142 0,13837721 ! tube morphogenesis GO:0035239 118 73 1,000 0,09223142 0,138287 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,09342326 0,13998273 ! superoxide anion generation GO:0042554 18 14 0,000 0,09342326 0,1398916 ! neuron maturation GO:0042551 21 14 0,000 0,09342326 0,13980058 ! regulation of S phase GO:0033261 18 14 0,000 0,09342326 0,13970968 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09342326 0,1396189 ! myotube differentiation GO:0014902 21 14 0,000 0,09342326 0,13952824 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09342326 0,1394377 ! inositol metabolic process GO:0006020 20 14 0,000 0,09342326 0,13934727 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09342326 0,13925696 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09342326 0,13916677 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,09342326 0,13907669 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09342326 0,13898673 ! gene silencing by RNA GO:0031047 20 14 0,000 0,09342326 0,13889689 ! response to cAMP GO:0051591 19 14 0,000 0,09342326 0,13880716 ! limbic system development GO:0021761 25 14 0,000 0,09342326 0,13871755 ! startle response GO:0001964 21 14 0,000 0,09342326 0,13862806 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09342326 0,13853868 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,09342326 0,13844941 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09342326 0,13836026 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,09342326 0,13827123 ! glycine metabolic process GO:0006544 22 14 0,000 0,09342326 0,13818231 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,09342326 0,1380935 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,09342326 0,13800481 ! regulation of heart rate GO:0002027 23 14 0,000 0,09342326 0,13791623 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09342326 0,13782777 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09342326 0,13773942 ! embryo implantation GO:0007566 27 14 0,000 0,09342326 0,13765118 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,09342326 0,13756305 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,09342326 0,13747504 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09342326 0,13738714 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09342326 0,13729935 ! axon cargo transport GO:0008088 27 14 0,000 0,09342326 0,13721168 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09342326 0,13712412 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09342326 0,13703666 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,09342326 0,13694932 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09342326 0,1368621 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09342326 0,13677498 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09342326 0,13668797 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09342326 0,13660107 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09342326 0,13651429 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09342326 0,13642761 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,09342326 0,13634105 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,09342326 0,13625459 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09342326 0,13616824 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,09342326 0,13608201 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09342326 0,13599588 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,09342326 0,13590986 ! cell killing GO:0001906 20 14 0,000 0,09342326 0,13582395 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,09342326 0,13573815 ! cilium assembly GO:0042384 20 14 0,000 0,09342326 0,13565246 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09342326 0,13556687 ! phospholipid biosynthetic process GO:0008654 102 74 1,000 0,09437662 0,13686395 ! response to nutrient GO:0007584 104 75 1,000 0,09653621 0,13990755 ! tRNA metabolic process GO:0006399 95 76 1,000 0,0987099 0,14296774 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,09975497 0,14439045 ! positive regulation of cell size GO:0045793 20 15 0,000 0,09975497 0,14429964 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,09975497 0,14420894 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,09975497 0,14411836 ! skin development GO:0043588 25 15 0,000 0,09975497 0,14402789 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,09975497 0,14393753 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,09975497 0,14384729 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,09975497 0,14375716 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,09975497 0,14366714 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,09975497 0,14357724 ! bile acid metabolic process GO:0008206 22 15 0,000 0,09975497 0,14348745 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,09975497 0,14339777 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,09975497 0,1433082 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,09975497 0,14321875 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,09975497 0,1431294 ! myoblast differentiation GO:0045445 27 15 0,000 0,09975497 0,14304017 ! centrosome cycle GO:0007098 16 15 0,000 0,09975497 0,14295105 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,09975497 0,14286204 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,09975497 0,14277314 ! cerebral cortex development GO:0021987 29 15 0,000 0,09975497 0,14268435 ! response to osmotic stress GO:0006970 22 15 0,000 0,09975497 0,14259567 ! vesicle coating GO:0006901 25 15 0,000 0,09975497 0,1425071 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,09975497 0,14241864 ! DNA integration GO:0015074 22 15 0,000 0,09975497 0,14233029 ! peptide secretion GO:0002790 27 15 0,000 0,09975497 0,14224205 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,09975497 0,14215392 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,09975497 0,1420659 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,09975497 0,14197799 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,09975497 0,14189019 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,09975497 0,14180249 ! biomineral formation GO:0031214 18 15 0,000 0,09975497 0,1417149 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,09975497 0,14162743 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,09975497 0,14154006 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,09975497 0,14145279 ! dopamine metabolic process GO:0042417 30 15 0,000 0,09975497 0,14136564 ! organic cation transport GO:0015695 19 15 0,000 0,09975497 0,14127859 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,09975497 0,14119165 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,09975497 0,14110482 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,09975497 0,14101809 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,09975497 0,14093147 ! peptide hormone processing GO:0016486 19 15 0,000 0,09975497 0,14084495 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,09975497 0,14075855 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,10089739 0,14228326 ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,10309838 0,14529796 ! T cell activation GO:0042110 134 79 1,000 0,10531258 0,14832757 ! ATP biosynthetic process GO:0006754 118 79 1,000 0,10531258 0,1482368 ! protein secretion GO:0009306 27 16 0,000 0,10604282 0,14917339 ! hormone secretion GO:0046879 25 16 0,000 0,10604282 0,1490822 ! bone remodeling GO:0046849 24 16 0,000 0,10604282 0,14899113 ! endothelial cell migration GO:0043542 22 16 0,000 0,10604282 0,14890018 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,10604282 0,14880933 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,10604282 0,14871859 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10604282 0,14862796 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,10604282 0,14853745 ! glial cell development GO:0021782 24 16 0,000 0,10604282 0,14844704 ! patterning of blood vessels GO:0001569 24 16 0,000 0,10604282 0,14835674 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,10604282 0,14826656 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,10604282 0,14817648 ! protein polyubiquitination GO:0000209 26 16 0,000 0,10604282 0,14808651 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,10604282 0,14799665 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,10604282 0,14790691 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,10604282 0,14781727 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,10604282 0,14772773 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,10604282 0,14763831 ! protein export from nucleus GO:0006611 24 16 0,000 0,10604282 0,14754899 ! negative regulation of immune response GO:0050777 28 16 0,000 0,10604282 0,14745979 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,10604282 0,14737069 ! DNA replication initiation GO:0006270 25 16 0,000 0,10604282 0,1472817 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,10604282 0,14719281 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,10604282 0,14710403 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,10604282 0,14701536 ! neural crest cell migration GO:0001755 24 16 0,000 0,10604282 0,1469268 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,10604282 0,14683834 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,10604282 0,14674999 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,10604282 0,14666175 ! steroid catabolic process GO:0006706 22 16 0,000 0,10604282 0,14657361 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,10604282 0,14648558 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,10604282 0,14639765 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,10604282 0,14630983 ! sperm-egg recognition GO:0035036 16 16 0,000 0,10604282 0,14622211 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,10604282 0,1461345 ! nerve development GO:0021675 18 16 0,000 0,10604282 0,146047 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,10604282 0,1459596 ! chromatin assembly GO:0031497 102 80 1,000 0,1075397 0,14793141 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 1,000 0,1075397 0,14784299 ! response to protein stimulus GO:0051789 111 81 1,000 0,10977947 0,150832 ! ossification GO:0001503 134 82 1,000 0,11203159 0,15383442 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,11203159 0,15374263 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,11228711 0,1540014 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,11228711 0,15390963 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,11228711 0,15381796 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,11228711 0,1537264 ! glycerol metabolic process GO:0006071 20 17 0,000 0,11228711 0,15363495 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,11228711 0,15354361 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,11228711 0,15345238 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,11228711 0,15336126 ! signal complex assembly GO:0007172 29 17 0,000 0,11228711 0,15327024 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,11228711 0,15317933 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,11228711 0,15308853 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,11228711 0,15299784 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,11228711 0,15290726 ! memory GO:0007613 25 17 0,000 0,11228711 0,15281678 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,11228711 0,15272641 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,11228711 0,15263614 ! retinoid metabolic process GO:0001523 22 17 0,000 0,11228711 0,15254599 GO:0016101|diterpenoid metabolic process, ! DNA duplex unwinding GO:0032508 25 17 0,000 0,11228711 0,15245594 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,11228711 0,15236599 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,11228711 0,15227615 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,11228711 0,15218642 ! membrane budding GO:0006900 29 17 0,000 0,11228711 0,15209679 ! heme metabolic process GO:0042168 27 17 0,000 0,11228711 0,15200727 ! neuromuscular junction development GO:0007528 23 17 0,000 0,11228711 0,15191786 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,11228711 0,15182855 ! body fluid secretion GO:0007589 27 17 0,000 0,11228711 0,15173934 ! stem cell differentiation GO:0048863 36 17 0,000 0,11228711 0,15165024 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,11228711 0,15156124 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,11228711 0,15147235 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,11228711 0,15138356 ! sensory perception of pain GO:0019233 23 17 0,000 0,11228711 0,15129488 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,11228711 0,1512063 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,11228711 0,15111782 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,11228711 0,15102945 ! synaptogenesis GO:0007416 24 17 0,000 0,11228711 0,15094118 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,11228711 0,15085301 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,11228711 0,15076495 ! cell-cell junction organization GO:0045216 25 17 0,000 0,11228711 0,15067699 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,11228711 0,15058913 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,11228711 0,15050137 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,11228711 0,15041372 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,11228711 0,15032617 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,11228711 0,15023872 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,11429579 0,15283739 ! protein-DNA complex assembly GO:0065004 107 84 1,000 0,1165718 0,15579032 ! sterol metabolic process GO:0016125 120 84 1,000 0,1165718 0,15569985 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,11848814 0,15816757 ! positive regulation of translation GO:0045727 28 18 0,000 0,11848814 0,15807582 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,11848814 0,15798419 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,11848814 0,15789265 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,11848814 0,15780123 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,11848814 0,15770991 ! cAMP metabolic process GO:0046058 33 18 0,000 0,11848814 0,15761869 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,11848814 0,15752758 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,11848814 0,15743658 ! axis specification GO:0009798 26 18 0,000 0,11848814 0,15734568 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,11848814 0,15725489 GO:0050886|endocrine process, ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,11848814 0,1571642 ! glutamine metabolic process GO:0006541 23 18 0,000 0,11848814 0,15707361 ! response to retinoic acid GO:0032526 25 18 0,000 0,11848814 0,15698313 ! fucose metabolic process GO:0006004 26 18 0,000 0,11848814 0,15689276 ! response to fungus GO:0009620 19 18 0,000 0,11848814 0,15680249 ! peptide cross-linking GO:0018149 31 18 0,000 0,11848814 0,15671232 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,11848814 0,15662225 ! heart process GO:0003015 27 18 0,000 0,11848814 0,15653229 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,11848814 0,15644244 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,11848814 0,15635268 ! visual learning GO:0008542 35 18 0,000 0,11848814 0,15626303 ! somitogenesis GO:0001756 24 18 0,000 0,11848814 0,15617348 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,11848814 0,15608403 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,11848814 0,15599469 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,11848814 0,15590545 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,11848814 0,15581631 ! vitamin transport GO:0051180 24 18 0,000 0,11848814 0,15572727 ! hormone transport GO:0009914 27 18 0,000 0,11848814 0,15563833 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,11848814 0,1555495 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,11848814 0,15546077 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,11848814 0,15537213 ! cell-cell recognition GO:0009988 20 18 0,000 0,11848814 0,1552836 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,11848814 0,15519517 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,11848814 0,15510684 ! regulation of glucose import GO:0046324 21 18 0,000 0,11848814 0,15501861 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,11848814 0,15493048 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,11848814 0,15484246 ! nucleosome organization GO:0034728 114 87 1,000 0,12346796 0,16125855 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 1,000 0,12346796 0,16116703 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! female pregnancy GO:0007565 130 87 1,000 0,12346796 0,16107561 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,12346796 0,1609843 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,1246462 0,16242848 ! positive regulation of ossification GO:0045778 30 19 0,000 0,1246462 0,16233651 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,1246462 0,16224464 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,1246462 0,16215287 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,1246462 0,1620612 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,1246462 0,16196964 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,1246462 0,16187819 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,1246462 0,16178683 ! sensory perception of taste GO:0050909 23 19 0,000 0,1246462 0,16169558 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,1246462 0,16160444 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,1246462 0,16151339 ! smooth muscle contraction GO:0006939 36 19 0,000 0,1246462 0,16142245 ! peroxisome organization GO:0007031 29 19 0,000 0,1246462 0,16133161 ! digestive system process GO:0022600 30 19 0,000 0,1246462 0,16124087 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,1246462 0,16115024 ! response to vitamin A GO:0033189 26 19 0,000 0,1246462 0,1610597 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,1246462 0,16096927 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,1246462 0,16087894 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,1246462 0,16078871 ! plasma membrane fusion GO:0045026 23 19 0,000 0,1246462 0,16069858 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,1246462 0,16060856 ! cytolysis GO:0019835 20 19 0,000 0,1246462 0,16051863 ! vasodilation GO:0042311 33 19 0,000 0,1246462 0,1604288 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,1246462 0,16033908 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,1246462 0,16024945 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,1246462 0,16015993 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,1246462 0,1600705 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,1246462 0,15998118 ! sarcomere organization GO:0045214 23 19 0,000 0,1246462 0,15989195 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,1246462 0,15980283 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,1246462 0,1597138 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,1246462 0,15962487 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,1246462 0,15953604 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,1246462 0,15944731 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,1246462 0,15935868 ! protein stabilization GO:0050821 26 19 0,000 0,1246462 0,15927015 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 1,000 0,1257885 0,16064051 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,1257885 0,16055136 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 1,000 0,12811953 0,1634359 ! leukocyte differentiation GO:0002521 143 90 1,000 0,13046078 0,16633027 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,1307616 0,16662143 ! iron ion transport GO:0006826 37 20 0,000 0,1307616 0,16652917 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,1307616 0,16643701 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,1307616 0,16634496 ! response to vitamin GO:0033273 29 20 0,000 0,1307616 0,166253 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,1307616 0,16616115 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,1307616 0,1660694 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,1307616 0,16597775 ! spinal cord development GO:0021510 31 20 0,000 0,1307616 0,1658862 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,1307616 0,16579475 ! chromosome condensation GO:0030261 31 20 0,000 0,1307616 0,16570341 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,1307616 0,16561216 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,1307616 0,16552101 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,1307616 0,16542997 ! pallium development GO:0021543 38 20 0,000 0,1307616 0,16533902 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,1307616 0,16524818 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,1307616 0,16515743 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,1307616 0,16506679 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,1307616 0,16497624 ! collagen catabolic process GO:0030574 25 20 0,000 0,1307616 0,16488579 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,1307616 0,16479544 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,1307616 0,16470519 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,1307616 0,16461504 ! alditol metabolic process GO:0019400 24 20 0,000 0,1307616 0,16452499 ! actin filament-based movement GO:0030048 34 20 0,000 0,1307616 0,16443504 ! ATP metabolic process GO:0046034 137 91 1,000 0,132812 0,16692219 ! response to virus GO:0009615 122 91 1,000 0,132812 0,16683103 ! positive regulation of immune response GO:0050778 121 92 1,000 0,13517295 0,16970403 ! DNA recombination GO:0006310 146 92 1,000 0,13517295 0,16961144 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,13683462 0,17160285 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,13683462 0,17150934 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,13683462 0,17141592 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,13683462 0,17132261 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,13683462 0,1712294 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,13683462 0,17113629 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,13683462 0,17104328 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,13683462 0,17095037 GO:0034105|positive regulation of tissue remodeling, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,13683462 0,17085756 ! protein amino acid acylation GO:0043543 37 21 0,000 0,13683462 0,17076486 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,13683462 0,17067225 ! phototransduction GO:0007602 25 21 0,000 0,13683462 0,17057975 ! dendrite development GO:0016358 35 21 0,000 0,13683462 0,17048734 ! visual behavior GO:0007632 39 21 0,000 0,13683462 0,17039504 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,13683462 0,17030283 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,13683462 0,17021072 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,13683462 0,17011872 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,13683462 0,17002681 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,13683462 0,16993501 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,13683462 0,1698433 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,13683462 0,16975169 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,13683462 0,16966018 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,13683462 0,16956877 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,13683462 0,16947745 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,13683462 0,16938624 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,13683462 0,16929512 ! fatty acid transport GO:0015908 30 21 0,000 0,13683462 0,1692041 ! immunoglobulin production GO:0002377 33 21 0,000 0,13683462 0,16911318 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,13683462 0,16902236 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,13683462 0,16893163 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,13683462 0,168841 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,13683462 0,16875047 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,13683462 0,16866004 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,13683462 0,1685697 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,13683462 0,16847946 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,13683462 0,16838932 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,13683462 0,16829927 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,13683462 0,16820932 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,13683462 0,16811946 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,13683462 0,1680297 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,13754336 0,16880989 ! regulation of binding GO:0051098 151 95 1,000 0,14231164 0,17456895 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,14286556 0,175155 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,14286556 0,17506169 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,14286556 0,17496847 ! viral genome replication GO:0019079 29 22 0,000 0,14286556 0,17487535 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,14286556 0,17478233 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,14286556 0,17468941 ! leukocyte adhesion GO:0007159 38 22 0,000 0,14286556 0,17459659 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,14286556 0,17450387 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,14286556 0,17441124 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,14286556 0,17431872 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,14286556 0,17422629 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,14286556 0,17413396 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,14286556 0,17404173 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,14286556 0,17394959 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,14286556 0,17385756 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,14286556 0,17376562 ! regulation of behavior GO:0050795 38 22 0,000 0,14286556 0,17367378 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,14286556 0,17358203 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,14286556 0,17349038 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,14286556 0,17339883 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,14286556 0,17330737 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,14286556 0,17321602 ! blastocyst development GO:0001824 37 22 0,000 0,14286556 0,17312475 ! neural tube closure GO:0001843 33 22 0,000 0,14286556 0,17303359 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,14286556 0,17294252 ! in utero embryonic development GO:0001701 147 96 1,000 0,14470902 0,17508193 ! response to light stimulus GO:0009416 153 96 1,000 0,14470902 0,17498988 ! protein amino acid glycosylation GO:0006486 134 97 1,000 0,14711492 0,17780574 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,1488547 0,17981397 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,1488547 0,17971958 ! myelination GO:0042552 35 23 0,000 0,1488547 0,17962529 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,1488547 0,1795311 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,1488547 0,17943701 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,1488547 0,17934301 ! vesicle targeting GO:0006903 32 23 0,000 0,1488547 0,17924911 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,1488547 0,17915532 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,1488547 0,17906161 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,1488547 0,17896801 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,1488547 0,17887451 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,1488547 0,1787811 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,1488547 0,17868779 ! pentose metabolic process GO:0019321 31 23 0,000 0,1488547 0,17859458 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,1488547 0,17850146 ! spermatid development GO:0007286 33 23 0,000 0,1488547 0,17840845 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,1488547 0,17831552 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,1488547 0,1782227 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,1488547 0,17812997 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,1488547 0,17803734 ! telomere organization GO:0032200 32 23 0,000 0,1488547 0,17794481 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,1488547 0,17785237 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,1488547 0,17776002 ! regulation of amine transport GO:0051952 38 23 0,000 0,1488547 0,17766778 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,15195133 0,18126974 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,15438139 0,1840732 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 1,000 0,15438139 0,18397782 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,15438139 0,18388255 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,15480233 0,18428849 ! initiation of viral infection GO:0019059 42 24 0,000 0,15480233 0,18419315 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,15480233 0,18409791 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,15480233 0,18400277 ! superoxide metabolic process GO:0006801 32 24 0,000 0,15480233 0,18390773 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,15480233 0,18381278 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,15480233 0,18371794 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,15480233 0,18362319 ! sperm motility GO:0030317 27 24 0,000 0,15480233 0,18352854 ! vacuole organization GO:0007033 39 24 0,000 0,15480233 0,18343398 ! receptor metabolic process GO:0043112 37 24 0,000 0,15480233 0,18333953 ! neural crest cell development GO:0014032 39 24 0,000 0,15480233 0,18324517 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 0,000 0,15480233 0,18315091 ! negative regulation of cell development GO:0010721 56 24 0,000 0,15480233 0,18305674 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,15480233 0,18296267 ! base-excision repair GO:0006284 31 24 0,000 0,15480233 0,1828687 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,15480233 0,18277483 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,15480233 0,18268105 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,15480233 0,18258737 ! glutathione metabolic process GO:0006749 29 24 0,000 0,15480233 0,18249378 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,15480233 0,18240029 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,15480233 0,18230689 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,16070874 0,18916587 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,16070874 0,18906911 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,16070874 0,18897245 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,16070874 0,18887589 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,16070874 0,18877942 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,16070874 0,18868306 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 43 25 0,000 0,16070874 0,18858679 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,16070874 0,18849062 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,16070874 0,18839455 ! phospholipid transport GO:0015914 35 25 0,000 0,16070874 0,18829858 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,16070874 0,1882027 ! detection of light stimulus GO:0009583 30 25 0,000 0,16070874 0,18810693 ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,16070874 0,18801125 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,16657421 0,19477412 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,16657421 0,19467515 ! translational initiation GO:0006413 43 26 0,000 0,16657421 0,19457628 ! regulation of pH GO:0006885 36 26 0,000 0,16657421 0,19447751 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,16657421 0,19437884 ! circadian rhythm GO:0007623 42 26 0,000 0,16657421 0,19428027 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,16657421 0,1941818 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,16657421 0,19408343 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,16657421 0,19398516 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,16657421 0,19388699 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,16657421 0,19378892 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,16657421 0,19369095 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,16657421 0,19359307 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,17239903 0,2002615 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,17239903 0,20016041 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,17239903 0,20005942 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,17239903 0,19995853 ! catechol metabolic process GO:0009712 43 27 0,000 0,17239903 0,19985774 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! acute-phase response GO:0006953 42 27 0,000 0,17239903 0,19975706 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,17239903 0,19965648 ! myofibril assembly GO:0030239 36 27 0,000 0,17239903 0,199556 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,17239903 0,19945562 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,17239903 0,19935534 ! natural killer cell activation GO:0030101 35 27 0,000 0,17239903 0,19925516 ! lipid oxidation GO:0034440 38 27 0,000 0,17239903 0,19915508 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,17239903 0,1990551 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,17239903 0,19895522 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,17239903 0,19885545 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,17239903 0,19875577 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,17239903 0,19865619 ! gene silencing GO:0016458 41 27 0,000 0,17239903 0,19855672 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,17818346 0,2051161 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,17818346 0,20501349 ! phenol metabolic process GO:0018958 44 28 0,000 0,17818346 0,20491098 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,17818346 0,20480858 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,17818346 0,20470628 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,17818346 0,20460408 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,17818346 0,20450198 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,17818346 0,20439998 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,17818346 0,20429809 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,17818346 0,2041963 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,17818346 0,2040946 ! ensheathment of neurons GO:0007272 43 28 0,000 0,17818346 0,20399301 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,17818346 0,20389152 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,17818346 0,20379014 ! neural tube formation GO:0001841 41 28 0,000 0,17818346 0,20368885 ! placenta development GO:0001890 37 28 0,000 0,17818346 0,20358766 ! regulation of B cell activation GO:0050864 42 28 0,000 0,17818346 0,20348658 ! regulation of innate immune response GO:0045088 38 29 0,000 0,1839278 0,2099424 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,1839278 0,20983826 ! protein targeting to membrane GO:0006612 53 29 0,000 0,1839278 0,20973423 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,1839278 0,20963029 ! mismatch repair GO:0006298 34 29 0,000 0,1839278 0,20952647 ! muscle cell development GO:0055001 38 29 0,000 0,1839278 0,20942274 ! telencephalon development GO:0021537 52 29 0,000 0,1839278 0,20931912 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,1839278 0,2092156 ! eye morphogenesis GO:0048592 51 29 0,000 0,1839278 0,20911218 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,1839278 0,20900886 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,18963231 0,21538484 ! collagen metabolic process GO:0032963 40 30 0,000 0,18963231 0,21527853 ! organic anion transport GO:0015711 51 30 0,000 0,18963231 0,21517233 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,18963231 0,21506623 ! spliceosome assembly GO:0000245 49 30 0,000 0,18963231 0,21496023 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,18963231 0,21485434 ! ceramide metabolic process GO:0006672 43 30 0,000 0,18963231 0,21474855 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,18963231 0,21464287 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,18963231 0,21453729 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,18963231 0,21443181 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,18963231 0,21432644 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,18963231 0,21422117 ! negative regulation of secretion GO:0051048 49 31 0,000 0,19529727 0,22051238 ! glial cell differentiation GO:0010001 55 31 0,000 0,19529727 0,22040418 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,19529727 0,22029608 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,19529727 0,22018809 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,19529727 0,22008021 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,19529727 0,21997243 ! segmentation GO:0035282 41 31 0,000 0,19529727 0,21986476 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,19529727 0,2197572 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,19529727 0,21964974 ! cell fate specification GO:0001708 37 31 0,000 0,19529727 0,21954238 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,19529727 0,21943513 ! RNA modification GO:0009451 40 31 0,000 0,19529727 0,21932798 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,20092295 0,22553576 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,20092295 0,22542574 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,20092295 0,22531583 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,20092295 0,22520603 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,20092295 0,22509633 ! peripheral nervous system development GO:0007422 53 32 0,000 0,20092295 0,22498675 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,20092295 0,22487726 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,20092295 0,22476789 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,20092295 0,22465862 ! vesicle localization GO:0051648 47 32 0,000 0,20092295 0,22454945 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,20650962 0,23068097 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,20650962 0,23056899 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,20650962 0,23045712 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,20650962 0,23034535 ! actomyosin structure organization GO:0031032 43 33 0,000 0,20650962 0,2302337 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,20650962 0,23012215 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,20650962 0,23001071 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,20650962 0,22989938 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,20650962 0,22978816 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,20650962 0,22967704 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,20650962 0,22956603 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,20650962 0,22945513 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,20650962 0,22934433 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,21205755 0,23539206 ! mRNA catabolic process GO:0006402 48 34 0,000 0,21205755 0,23527851 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,21205755 0,23516507 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,21205755 0,23505174 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,21205755 0,23493851 ! feeding behavior GO:0007631 45 34 0,000 0,21205755 0,2348254 ! neuron migration GO:0001764 46 34 0,000 0,21205755 0,23471239 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,21205755 0,2345995 ! polyol metabolic process GO:0019751 44 34 0,000 0,21205755 0,23448671 ! aerobic respiration GO:0009060 47 34 0,000 0,21205755 0,23437403 ! embryonic organ development GO:0048568 45 34 0,000 0,21205755 0,23426146 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,21205755 0,23414899 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,217567 0,24011713 ! Notch signaling pathway GO:0007219 56 35 0,000 0,217567 0,24000197 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,217567 0,23988691 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,217567 0,23977197 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,217567 0,23965714 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,217567 0,23954241 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,217567 0,2394278 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,217567 0,2393133 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,217567 0,2391989 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,217567 0,23908462 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,22303825 0,24497993 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 0,000 0,22303825 0,24486299 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,22303825 0,24474617 ! negative regulation of binding GO:0051100 58 36 0,000 0,22303825 0,24462946 ! neural tube development GO:0021915 50 36 0,000 0,22303825 0,24451285 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,22303825 0,24439636 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,22303825 0,24427998 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,22303825 0,24416372 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,22847155 0,24999265 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,22847155 0,24987378 ! learning GO:0007612 67 37 0,000 0,22847155 0,24975502 ! ion transmembrane transport GO:0034220 56 37 0,000 0,22847155 0,24963637 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,22847155 0,24951783 ! regulation of protein secretion GO:0050708 51 37 0,000 0,22847155 0,24939941 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,22847155 0,2492811 ! gliogenesis GO:0042063 71 38 0,000 0,23386716 0,25504716 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,23386716 0,25492629 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,23386716 0,25480553 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,23386716 0,25468488 ! phagocytosis GO:0006909 60 38 0,000 0,23386716 0,25456435 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,23922535 0,26027355 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,23922535 0,26015049 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,23922535 0,26002755 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,23922535 0,25990472 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,23922535 0,25978201 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,23922535 0,25965941 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,23922535 0,25953693 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,23922535 0,25941457 ! cell growth GO:0016049 61 39 0,000 0,23922535 0,25929232 ! synapse organization GO:0050808 55 39 0,000 0,23922535 0,25917018 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,24454636 0,26481009 ! regulation of tube size GO:0035150 60 40 0,000 0,24454636 0,26468548 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,24454636 0,26456098 ! peptide metabolic process GO:0006518 56 40 0,000 0,24454636 0,26443659 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,24454636 0,26431233 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,24454636 0,26418818 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,24983047 0,26976999 ! endosome transport GO:0016197 71 41 0,000 0,24983047 0,2696434 ! striated muscle contraction GO:0006941 62 41 0,000 0,24983047 0,26951692 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,24983047 0,26939056 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,24983047 0,26926433 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,24983047 0,26913821 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,24983047 0,26901221 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,25507791 0,27453402 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,25507791 0,27440561 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,25507791 0,27427732 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,25507791 0,27414916 ! excretion GO:0007588 63 42 0,000 0,25507791 0,27402111 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,25507791 0,27389318 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,25507791 0,27376537 ! regulation of cell shape GO:0008360 78 42 0,000 0,25507791 0,27363769 ! positive regulation of binding GO:0051099 59 43 0,000 0,26028895 0,27909771 ! neuromuscular process GO:0050905 79 43 0,000 0,26028895 0,27896765 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,26028895 0,27883772 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,26028895 0,27870791 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,26546383 0,28411671 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,26546383 0,28398456 ! regulation of ion transport GO:0043269 57 44 0,000 0,26546383 0,28385254 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,26546383 0,28372064 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,26546383 0,28358886 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,26546383 0,2834572 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,26546383 0,28332567 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,26546383 0,28319425 ! RNA catabolic process GO:0006401 64 45 0,000 0,2706028 0,28854263 ! regulation of translational initiation GO:0006446 64 45 0,000 0,2706028 0,28840892 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,2706028 0,28827533 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,27570612 0,29357596 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,27570612 0,2934401 ! cell redox homeostasis GO:0045454 63 46 0,000 0,27570612 0,29330438 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,27570612 0,29316878 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,27570612 0,2930333 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,28077401 0,29828186 ! viral infectious cycle GO:0019058 71 47 0,000 0,28077401 0,29814415 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,28077401 0,29800657 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,28077401 0,29786911 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,28077401 0,29773178 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,28077401 0,29759458 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! chloride transport GO:0006821 67 48 0,000 0,28580674 0,30278927 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,28580674 0,30264986 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,28580674 0,30251058 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,28580674 0,30237143 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,28580674 0,30223241 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,28580674 0,30209352 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,29080453 0,30723492 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,29080453 0,30709386 ! sensory perception of smell GO:0007608 61 49 0,000 0,29080453 0,30695293 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,29080453 0,30681212 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,29080453 0,30667145 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,29080453 0,3065309 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,29080453 0,30639049 ! cartilage development GO:0051216 70 49 0,000 0,29080453 0,3062502 ! regulation of actin filament length GO:0030832 72 50 0,000 0,29576764 0,31133436 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,29576764 0,31119194 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,29576764 0,31104965 ! proton transport GO:0015992 75 50 0,000 0,29576764 0,31090748 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,29576764 0,31076545 ! positive regulation of secretion GO:0051047 71 51 0,000 0,3006963 0,31579977 ! hydrogen transport GO:0006818 77 51 0,000 0,3006963 0,31565563 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,3006963 0,31551163 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 0,000 0,3006963 0,31536776 ! transition metal ion transport GO:0000041 74 52 0,000 0,30559074 0,32035493 ! regulation of cellular component size GO:0032535 74 52 0,000 0,30559074 0,32020898 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,30559074 0,32006316 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,30559074 0,31991748 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,31045121 0,32485795 ! single fertilization GO:0007338 59 53 0,000 0,31045121 0,32471022 ! cell projection assembly GO:0030031 76 53 0,000 0,31045121 0,32456263 ! amino acid transport GO:0006865 84 54 0,000 0,31527793 0,32945899 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,31527793 0,32930937 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,31527793 0,32915989 ! exocytosis GO:0006887 74 55 0,000 0,32007114 0,33401254 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,32007114 0,33386106 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,32007114 0,33370971 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,32955795 0,34344508 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,32955795 0,34328954 ! camera-type eye development GO:0043010 88 57 0,000 0,32955795 0,34313413 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,33891347 0,35271538 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,34354255 0,35737127 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,34354255 0,35720971 GO:0035113|embryonic appendage morphogenesis, ! fertilization GO:0009566 68 60 0,000 0,34354255 0,35704829 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,34813949 0,36166252 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,34813949 0,36149925 ! neurotransmitter transport GO:0006836 81 62 0,000 0,3527045 0,36607416 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,3527045 0,36590904 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,3572378 0,37044496 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,3572378 0,37027802 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,3572378 0,37011123 ! regulation of lipase activity GO:0060191 109 63 0,000 0,3572378 0,36994459 ! appendage morphogenesis GO:0035107 93 64 0,000 0,3617396 0,37443793 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,3617396 0,37426949 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,3617396 0,37410121 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,3617396 0,37393307 ! appendage development GO:0048736 94 65 0,000 0,36621014 0,37838424 GO:0060173|limb development, ! defense response to bacterium GO:0042742 73 65 0,000 0,36621014 0,37821433 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,36621014 0,37804458 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,37064961 0,38245586 ! antigen processing and presentation GO:0019882 96 66 0,000 0,37064961 0,38228436 ! regulation of immune effector process GO:0002697 101 66 0,000 0,37064961 0,382113 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,37505825 0,38648475 ! learning or memory GO:0007611 123 68 0,000 0,37943625 0,39082103 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,37943625 0,39064609 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,37943625 0,39047131 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,37943625 0,39029668 ! inorganic anion transport GO:0015698 93 68 0,000 0,37943625 0,3901222 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,38378383 0,39441591 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,38378383 0,39423975 ! eye development GO:0001654 111 70 0,000 0,3881012 0,39849677 ! amine transport GO:0015837 101 70 0,000 0,3881012 0,39831895 ! positive regulation of phosphorylation GO:0042327 102 70 0,000 0,3881012 0,39814128 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,39238857 0,4023601 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 0,000 0,39664614 0,40654462 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,39664614 0,40636353 ! regulation of blood pressure GO:0008217 107 73 0,000 0,40087412 0,41051224 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,40087412 0,41032954 ! digestion GO:0007586 97 74 0,000 0,40507272 0,41444273 ! protein import into nucleus GO:0006606 118 74 0,000 0,40507272 0,41425845 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,40507272 0,41407433 ! blood coagulation GO:0007596 116 75 0,000 0,40924213 0,41815056 GO:0050817|coagulation, ! nuclear import GO:0051170 121 75 0,000 0,40924213 0,41796488 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,40924213 0,41777936 ! amine biosynthetic process GO:0009309 97 76 0,000 0,41338256 0,42181894 ! response to unfolded protein GO:0006986 99 76 0,000 0,41338256 0,42163188 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,41338256 0,42144499 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,41749421 0,42544824 ! regulation of DNA binding GO:0051101 119 77 0,000 0,41749421 0,42525982 ! protein ubiquitination GO:0016567 125 77 0,000 0,41749421 0,42507157 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,41749421 0,42488349 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,41749421 0,42469557 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,42157727 0,42865947 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,42157727 0,42847005 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,42563195 0,43239994 ! cellular respiration GO:0045333 107 79 0,000 0,42563195 0,43220904 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,42563195 0,4320183 ! regulation of lyase activity GO:0051339 133 79 0,000 0,42563195 0,43182773 ! protein localization in nucleus GO:0034504 133 80 0,000 0,42965843 0,43572063 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,42965843 0,4355286 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,43365692 0,43938807 ! hemostasis GO:0007599 125 81 0,000 0,43365692 0,43919459 ! mRNA transport GO:0051028 121 81 0,000 0,43365692 0,43900128 ! regulation of neurological system process GO:0031644 122 81 0,000 0,43365692 0,43880814 ! vitamin metabolic process GO:0006766 103 81 0,000 0,43365692 0,43861518 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,43365692 0,43842238 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,44157067 0,44622695 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,44157067 0,44603098 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,44937474 0,45371462 ! rRNA metabolic process GO:0016072 107 85 0,000 0,44937474 0,45351553 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,44937474 0,45331662 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,45323611 0,45701142 ! cellular defense response GO:0006968 102 87 0,000 0,45707062 0,46067591 ! establishment of RNA localization GO:0051236 128 88 0,000 0,46087846 0,46431032 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,46465981 0,46791487 ! regulation of T cell activation GO:0050863 128 89 0,000 0,46465981 0,4677101 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,46841486 0,47128354 ! hormone metabolic process GO:0042445 121 90 0,000 0,46841486 0,47107747 ! RNA localization GO:0006403 135 91 0,000 0,47214378 0,47462006 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,47584676 0,47813348 ! sulfur metabolic process GO:0006790 118 92 0,000 0,47584676 0,47792469 ! electron transport chain GO:0022900 123 94 0,000 0,48317559 0,4850737 ! angiogenesis GO:0001525 149 95 0,000 0,4868018 0,48850094 ! carboxylic acid transport GO:0046942 147 95 0,000 0,4868018 0,48828789 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,49040278 0,49168544 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,49040278 0,49147119 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,49397869 0,49483928 ! protein import GO:0017038 156 99 0,000 0,50105603 0,50171043 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,50455779 0,50499692 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,50455779 0,50477726 ! protein localization in organelle GO:0033365 161 100 0,000 0,50455779 0,50455779