pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1242-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of lipid kinase activity GO:0043550 17 8 3,000 3,929E-09 9,599E-06 ! nuclear migration GO:0007097 13 6 2,000 4,166E-07 5,089E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 4,166E-07 3,393E-04 GO:0031272|regulation of pseudopodium assembly, ! establishment of nucleus localization GO:0040023 18 8 2,000 1,162E-06 7,096E-04 ! regulation of lipid metabolic process GO:0019216 132 66 4,000 1,182E-06 5,777E-04 ! macrophage differentiation GO:0030225 15 9 2,000 1,739E-06 7,082E-04 ! response to hypoxia GO:0001666 178 81 4,000 3,279E-06 1,145E-03 ! nucleus localization GO:0051647 22 11 2,000 3,403E-06 1,039E-03 ! response to oxygen levels GO:0070482 183 83 4,000 3,7E-06 1,004E-03 ! regulation of cell projection assembly GO:0060491 33 12 2,000 4,528E-06 1,106E-03 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 3,000 8,445E-06 1,876E-03 ! response to estrogen stimulus GO:0043627 98 52 3,000 1,383E-05 2,816E-03 ! filopodium assembly GO:0046847 42 17 2,000 1,385E-05 2,603E-03 ! microspike assembly GO:0030035 46 18 2,000 1,659E-05 2,895E-03 ! regulation of heart contraction GO:0008016 123 61 3,000 2,616E-05 4,26E-03 ! collagen catabolic process GO:0030574 29 21 2,000 2,688E-05 4,104E-03 ! myeloid cell differentiation GO:0030099 126 67 3,000 3,793E-05 5,451E-03 ! cell projection assembly GO:0030031 138 68 3,000 4,021E-05 5,458E-03 ! lung development GO:0030324 165 69 3,000 4,26E-05 5,477E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 4,61E-05 5,632E-03 ! respiratory tube development GO:0030323 171 72 3,000 5,037E-05 5,86E-03 ! respiratory system development GO:0060541 175 74 3,000 5,609E-05 6,229E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 5,84E-05 6,203E-03 ! multicellular organismal catabolic process GO:0044243 38 27 2,000 5,84E-05 5,944E-03 ! response to steroid hormone stimulus GO:0048545 147 79 3,000 7,247E-05 7,082E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 2,000 7,266E-05 6,827E-03 ! microvillus organization GO:0032528 8 5 1,000 7,638E-05 6,911E-03 GO:0030033|microvillus assembly, ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 7,638E-05 6,664E-03 ! regulation of centrosome cycle GO:0046605 7 5 1,000 7,638E-05 6,434E-03 ! glial cell migration GO:0008347 10 5 1,000 7,638E-05 6,22E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 7,638E-05 6,019E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 8,057E-05 6,151E-03 ! collagen metabolic process GO:0032963 49 32 2,000 9,803E-05 7,257E-03 ! response to mechanical stimulus GO:0009612 60 32 2,000 9,803E-05 7,044E-03 ! positive regulation of DNA repair GO:0045739 9 6 1,000 1,144E-04 7,982E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 1,000 1,144E-04 7,761E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! negative regulation of gliogenesis GO:0014014 18 6 1,000 1,144E-04 7,551E-03 GO:0045686|negative regulation of glial cell differentiation, ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 1,144E-04 7,352E-03 ! ossification GO:0001503 205 91 3,000 1,257E-04 7,872E-03 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 2,000 1,286E-04 7,853E-03 ! bone development GO:0060348 206 92 3,000 1,311E-04 7,811E-03 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 1,52E-04 8,843E-03 ! positive regulation of protein ubiquitination GO:0031398 14 7 1,000 1,598E-04 9,08E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,598E-04 8,873E-03 ! negative regulation of focal adhesion formation GO:0051895 21 7 1,000 1,598E-04 8,676E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 1,673E-04 8,887E-03 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 2,069E-04 0,01075369 ! multicellular organismal metabolic process GO:0044236 64 41 2,000 2,069E-04 0,01052965 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 2,127E-04 0,01060433 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 2,127E-04 0,01039225 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 2,127E-04 0,01018848 ! regulation of focal adhesion formation GO:0051893 23 8 1,000 2,127E-04 9,993E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 2,73E-04 0,01258225 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 2,73E-04 0,01234924 ! postreplication repair GO:0006301 25 9 1,000 2,73E-04 0,01212471 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 1,000 2,73E-04 0,0119082 ! regulation of macrophage differentiation GO:0045649 16 9 1,000 2,73E-04 0,01169928 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 1,000 3,406E-04 0,01434585 ! motor axon guidance GO:0008045 22 10 1,000 3,406E-04 0,0141027 ! regulation of gliogenesis GO:0014013 23 10 1,000 3,406E-04 0,01386766 GO:0045685|regulation of glial cell differentiation, ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 3,406E-04 0,01364032 ! induction of an organ GO:0001759 17 10 1,000 3,406E-04 0,01342031 ! regulation of cell projection organization GO:0031344 135 51 2,000 3,961E-04 0,01535955 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 4,155E-04 0,01586116 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 4,155E-04 0,01561714 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 4,155E-04 0,01538052 ! neuroblast proliferation GO:0007405 25 11 1,000 4,155E-04 0,01515096 ! hippocampus development GO:0021766 29 12 1,000 4,977E-04 0,01788125 ! ventral spinal cord development GO:0021517 25 12 1,000 4,977E-04 0,0176221 ! entry into host cell GO:0030260 34 12 1,000 4,977E-04 0,01737035 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 4,977E-04 0,0171257 ! zymogen activation GO:0031638 18 12 1,000 4,977E-04 0,01688784 ! peptidyl-lysine modification GO:0018205 21 12 1,000 4,977E-04 0,0166565 ! developmental induction GO:0031128 22 12 1,000 4,977E-04 0,01643142 GO:0045168|cell-cell signaling involved in cell fate specification, ! localization within membrane GO:0051668 26 12 1,000 4,977E-04 0,01621233 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 5,871E-04 0,01887359 GO:0000725|recombinational repair, ! negative regulation of lipid metabolic process GO:0045833 20 13 1,000 5,871E-04 0,01862848 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 5,871E-04 0,01838965 ! regulation of DNA repair GO:0006282 23 13 1,000 5,871E-04 0,01815687 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 5,871E-04 0,01792991 ! establishment of organelle localization GO:0051656 122 59 2,000 6,084E-04 0,01835053 ! bone mineralization GO:0030282 18 14 1,000 6,838E-04 0,02037098 ! regulation of protein complex assembly GO:0043254 132 63 2,000 7,373E-04 0,02170018 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 7,875E-04 0,02290369 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 7,875E-04 0,02263424 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 8,444E-04 0,02398804 ! regulation of protein ubiquitination GO:0031396 28 16 1,000 8,984E-04 0,02522718 ! embryonic hindlimb morphogenesis GO:0035116 36 16 1,000 8,984E-04 0,02494051 ! biomineral formation GO:0031214 22 16 1,000 8,984E-04 0,02466028 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 1,016E-03 0,02758764 ! cell cycle checkpoint GO:0000075 145 71 2,000 1,044E-03 0,0280317 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 1,044E-03 0,02772701 ! limbic system development GO:0021761 40 18 1,000 1,141E-03 0,02998046 ! centrosome cycle GO:0007098 26 18 1,000 1,141E-03 0,02966151 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 1,141E-03 0,02934929 ! organelle localization GO:0051640 155 74 2,000 1,177E-03 0,02995575 ! regulation of lipid biosynthetic process GO:0046890 28 19 1,000 1,273E-03 0,03206756 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 1,273E-03 0,03174034 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 1,412E-03 0,03484751 ! protein amino acid acetylation GO:0006473 41 20 1,000 1,412E-03 0,03449904 ! regulation of fatty acid metabolic process GO:0019217 45 20 1,000 1,412E-03 0,03415746 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 1,412E-03 0,03382259 ! lipid phosphorylation GO:0046834 43 21 1,000 1,558E-03 0,03695281 ! ovarian follicle development GO:0001541 39 21 1,000 1,558E-03 0,0365975 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 1,558E-03 0,03624895 ! hindlimb morphogenesis GO:0035137 47 22 1,000 1,711E-03 0,0394261 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 1,711E-03 0,03905763 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 1,711E-03 0,03869598 ! G1 phase GO:0051318 44 22 1,000 1,711E-03 0,03834097 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 1,87E-03 0,04153535 GO:0010810|regulation of cell-substrate adhesion, ! tube morphogenesis GO:0035239 194 89 2,000 2,001E-03 0,04403948 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 2,037E-03 0,04442155 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 2,037E-03 0,04402844 ! pallium development GO:0021543 56 24 1,000 2,037E-03 0,04364222 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 2,037E-03 0,04326272 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 2,21E-03 0,04653488 ! interaction with host GO:0051701 66 25 1,000 2,21E-03 0,04613715 ! initiation of viral infection GO:0019059 60 26 1,000 2,389E-03 0,0494686 ! microtubule organizing center organization GO:0031023 42 26 1,000 2,389E-03 0,04905289 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 1,000 2,389E-03 0,04864412 ! regulation of cellular ketone metabolic process GO:0010565 51 26 1,000 2,389E-03 0,0482421 ! negative regulation of cell development GO:0010721 83 26 1,000 2,389E-03 0,04784668 GO:0050768|negative regulation of neurogenesis, ! neural tube closure GO:0001843 58 26 1,000 2,389E-03 0,04745768 GO:0060606|tube closure, ! iron ion transport GO:0006826 65 27 1,000 2,576E-03 0,05074891 ! tube lumen formation GO:0035148 59 27 1,000 2,576E-03 0,05034292 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 2,576E-03 0,04994337 ! leukocyte differentiation GO:0002521 232 98 2,000 2,632E-03 0,05062852 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 2,769E-03 0,05284895 ! protein amino acid acylation GO:0043543 59 28 1,000 2,769E-03 0,05243927 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 2,969E-03 0,05578926 ! primary neural tube formation GO:0014020 61 29 1,000 2,969E-03 0,05536339 ! somitogenesis GO:0001756 52 29 1,000 2,969E-03 0,05494397 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 2,969E-03 0,05453085 ! ovulation cycle process GO:0022602 55 31 1,000 3,388E-03 0,06176513 ! iron ion homeostasis GO:0055072 60 31 1,000 3,388E-03 0,06130761 ! erythrocyte differentiation GO:0030218 62 31 1,000 3,388E-03 0,06085682 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 3,388E-03 0,06041261 ! ovulation cycle GO:0042698 57 32 1,000 3,607E-03 0,06385746 ! leukocyte chemotaxis GO:0030595 55 33 1,000 3,833E-03 0,06736623 GO:0060326|cell chemotaxis, ! cell fate specification GO:0001708 56 34 1,000 4,065E-03 0,07093689 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 4,065E-03 0,07043379 ! telencephalon development GO:0021537 81 35 1,000 4,304E-03 0,07404238 ! calcium-mediated signaling GO:0019722 67 35 1,000 4,304E-03 0,0735246 ! negative regulation of cell adhesion GO:0007162 94 37 1,000 4,8E-03 0,08143156 ! tissue remodeling GO:0048771 78 37 1,000 4,8E-03 0,08086996 ! female gonad development GO:0008585 71 37 1,000 4,8E-03 0,08031605 ! regulation of microtubule-based process GO:0032886 86 37 1,000 4,8E-03 0,07976969 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 5,057E-03 0,08348135 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 5,057E-03 0,08292108 ! neural tube formation GO:0001841 79 38 1,000 5,057E-03 0,08236827 ! erythrocyte homeostasis GO:0034101 75 39 1,000 5,321E-03 0,0860899 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 5,591E-03 0,08986222 GO:0046660|female sex differentiation, ! gliogenesis GO:0042063 91 41 1,000 5,867E-03 0,09368368 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 5,867E-03 0,09307535 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 6,438E-03 0,10146794 GO:0090047|positive regulation of transcription regulator activity, ! striated muscle cell differentiation GO:0051146 91 43 1,000 6,438E-03 0,10081751 ! segmentation GO:0035282 78 43 1,000 6,438E-03 0,10017536 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 6,438E-03 0,09954133 ! double-strand break repair GO:0006302 85 44 1,000 6,732E-03 0,10343861 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 7,033E-03 0,10737915 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 7,033E-03 0,10671219 ! induction of apoptosis by intracellular signals GO:0008629 95 45 1,000 7,033E-03 0,10605348 ! leukocyte migration GO:0050900 75 46 1,000 7,339E-03 0,10999519 ! cell growth GO:0016049 90 46 1,000 7,339E-03 0,10932449 ! neural tube development GO:0021915 91 47 1,000 7,651E-03 0,11328674 ! response to insulin stimulus GO:0032868 98 47 1,000 7,651E-03 0,11260429 ! positive regulation of cell cycle GO:0045787 96 48 1,000 7,97E-03 0,11658603 ! positive regulation of DNA binding GO:0043388 83 48 1,000 7,97E-03 0,11589207 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 8,624E-03 0,1246628 ! viral infectious cycle GO:0019058 104 51 1,000 8,96E-03 0,12875551 ! positive regulation of binding GO:0051099 88 52 1,000 9,301E-03 0,13288293 ! Notch signaling pathway GO:0007219 111 52 1,000 9,301E-03 0,13211035 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 9,301E-03 0,13134671 ! histone modification GO:0016570 104 52 1,000 9,301E-03 0,13059184 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 9,301E-03 0,1298456 ! cartilage development GO:0051216 99 53 1,000 9,649E-03 0,13392934 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,01000168 0,13804577 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 1,000 0,01000168 0,13727023 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,01000168 0,13650336 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,01036042 0,14061395 ! response to UV GO:0009411 120 55 1,000 0,01036042 0,13983707 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,01072481 0,14395995 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 1,000 0,01109481 0,14811267 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,01109481 0,14730771 ! positive regulation of cell migration GO:0030335 137 58 1,000 0,01147039 0,15147109 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,01147039 0,15065673 ! lipid modification GO:0030258 112 60 1,000 0,01223814 0,15988115 ! viral reproductive process GO:0022415 132 62 1,000 0,01302781 0,16929219 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,01302781 0,16839646 ! protein amino acid autophosphorylation GO:0046777 157 64 1,000 0,01383912 0,17794201 ! response to peptide hormone stimulus GO:0043434 129 64 1,000 0,01383912 0,17701037 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01384981 0,17622446 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01384981 0,17531138 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01384981 0,17440771 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01384981 0,17351331 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01384981 0,17262804 ! neuron fate determination GO:0048664 7 5 0,000 0,01384981 0,17175175 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01384981 0,17088432 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01384981 0,17002561 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01384981 0,16917548 ! polyol transport GO:0015791 12 5 0,000 0,01384981 0,16833381 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01384981 0,16750047 ! response to superoxide GO:0000303 10 5 0,000 0,01384981 0,16667535 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01384981 0,16585831 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01384981 0,16504925 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01384981 0,16424804 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01384981 0,16345457 ! female meiosis GO:0007143 10 5 0,000 0,01384981 0,16266873 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01384981 0,16189041 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01384981 0,1611195 ! hypothalamus development GO:0021854 9 5 0,000 0,01384981 0,1603559 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01384981 0,15959951 ! cobalt ion transport GO:0006824 11 5 0,000 0,01384981 0,15885021 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01384981 0,15810792 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01384981 0,15737254 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01384981 0,15664396 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01384981 0,1559221 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01384981 0,15520686 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01384981 0,15449815 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01384981 0,15379589 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01384981 0,15309998 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01384981 0,15241034 ! transposition GO:0032196 9 5 0,000 0,01384981 0,15172689 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01384981 0,15104953 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01384981 0,1503782 ! negative chemotaxis GO:0050919 16 5 0,000 0,01384981 0,14971281 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01384981 0,14905328 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01384981 0,14839954 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01384981 0,14775151 ! behavioral response to pain GO:0048266 10 5 0,000 0,01384981 0,14710911 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01384981 0,14647228 ! Notch receptor processing GO:0007220 11 5 0,000 0,01384981 0,14584093 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01384981 0,145215 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01384981 0,14459443 ! micturition GO:0060073 9 5 0,000 0,01384981 0,14397913 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01384981 0,14336905 ! copulation GO:0007620 9 5 0,000 0,01384981 0,14276412 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01384981 0,14216427 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01384981 0,14156944 ! bioluminescence GO:0008218 9 5 0,000 0,01384981 0,14097956 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01384981 0,14039459 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01384981 0,13981444 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01384981 0,13923908 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01384981 0,13866842 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01384981 0,13810243 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01384981 0,13754104 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01384981 0,13698419 ! grooming behavior GO:0007625 6 5 0,000 0,01384981 0,13643184 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01384981 0,13588392 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01384981 0,13534038 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01384981 0,13480118 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01384981 0,13426625 ! response to protozoan GO:0001562 13 5 0,000 0,01384981 0,13373556 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,01384981 0,13320904 ! lymph vessel development GO:0001945 10 5 0,000 0,01384981 0,13268665 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01384981 0,13216834 ! endochondral ossification GO:0001958 17 5 0,000 0,01384981 0,13165407 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01384981 0,13114378 ! single strand break repair GO:0000012 8 5 0,000 0,01384981 0,13063743 ! parathyroid gland development GO:0060017 14 5 0,000 0,01384981 0,13013498 ! anagen GO:0042640 7 5 0,000 0,01384981 0,12963638 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01384981 0,12914159 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01384981 0,12865055 ! cytokine secretion GO:0050663 15 5 0,000 0,01384981 0,12816324 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01384981 0,12767961 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01384981 0,12719961 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01384981 0,1267232 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01384981 0,12625036 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01384981 0,12578102 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01384981 0,12531517 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01384981 0,12485275 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01384981 0,12439373 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01384981 0,12393808 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01384981 0,12348575 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01384981 0,12303671 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01384981 0,12259093 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01384981 0,12214836 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01384981 0,12170898 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01384981 0,12127274 ! valine metabolic process GO:0006573 12 5 0,000 0,01384981 0,12083963 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01384981 0,12040959 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01384981 0,11998261 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01384981 0,11955864 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01384981 0,11913766 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01384981 0,11871963 ! polyol catabolic process GO:0046174 9 5 0,000 0,01384981 0,11830453 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01384981 0,11789232 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01384981 0,11748297 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01384981 0,11707646 ! muscle cell migration GO:0014812 8 5 0,000 0,01384981 0,11667274 ! mitochondrial fission GO:0000266 8 5 0,000 0,01384981 0,11627181 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01384981 0,11587361 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01384981 0,11547814 ! mRNA transcription GO:0009299 10 5 0,000 0,01384981 0,11508536 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01384981 0,11469524 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01384981 0,11430776 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01384981 0,11392288 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01384981 0,11354059 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01384981 0,11316085 ! monocyte activation GO:0042117 10 5 0,000 0,01384981 0,11278365 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01384981 0,11240896 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01384981 0,11203674 ! response to food GO:0032094 6 5 0,000 0,01384981 0,11166698 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01384981 0,11129966 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01384981 0,11093474 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01384981 0,11057221 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01384981 0,11021204 ! forebrain neuron development GO:0021884 13 5 0,000 0,01384981 0,10985421 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01384981 0,10949869 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01384981 0,10914547 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01384981 0,10879452 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01384981 0,10844582 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01384981 0,10809935 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01384981 0,10775508 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01384981 0,107413 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01384981 0,10707309 ! lipid glycosylation GO:0030259 7 5 0,000 0,01384981 0,10673532 ! nucleobase transport GO:0015851 6 5 0,000 0,01384981 0,10639967 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01384981 0,10606613 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01384981 0,10573467 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01384981 0,10540528 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01384981 0,10507794 ! basic amino acid transport GO:0015802 12 5 0,000 0,01384981 0,10475262 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01384981 0,10442931 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01384981 0,10410799 ! actin nucleation GO:0045010 11 5 0,000 0,01384981 0,10378864 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01384981 0,10347124 ! depurination GO:0045007 5 5 0,000 0,01384981 0,10315578 ! depyrimidination GO:0045008 10 5 0,000 0,01384981 0,10284224 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01384981 0,10253059 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01384981 0,10222083 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01384981 0,10191294 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01384981 0,10160689 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01384981 0,10130268 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01384981 0,10100029 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01384981 0,10069969 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01384981 0,10040088 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01384981 0,10010383 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01384981 0,09980854 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01384981 0,09951499 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01384981 0,09922315 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01384981 0,09893303 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01384981 0,09864459 ! response to arsenic GO:0046685 11 5 0,000 0,01384981 0,09835784 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01384981 0,09807274 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01384981 0,09778929 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01384981 0,09750748 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01384981 0,09722729 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01384981 0,0969487 ! response to mercury ion GO:0046689 8 5 0,000 0,01384981 0,0966717 ! response to cadmium ion GO:0046686 7 5 0,000 0,01384981 0,09639628 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01384981 0,09612243 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01384981 0,09585013 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01384981 0,09557937 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01384981 0,09531013 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01384981 0,0950424 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01384981 0,09477618 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01384981 0,09451144 ! decidualization GO:0046697 11 5 0,000 0,01384981 0,09424818 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01384981 0,09398638 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01384981 0,09372603 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01384981 0,09346711 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01384981 0,09320963 ! embryonic cleavage GO:0040016 6 5 0,000 0,01384981 0,09295356 ! peroxisome fission GO:0016559 5 5 0,000 0,01384981 0,09269889 ! histone demethylation GO:0016577 13 5 0,000 0,01384981 0,09244562 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01384981 0,09219372 ! mitotic recombination GO:0006312 9 5 0,000 0,01384981 0,09194319 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01384981 0,09169403 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01384981 0,0914462 ! metaphase plate congression GO:0051310 7 5 0,000 0,01384981 0,09119972 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01384981 0,09095456 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01384981 0,09071071 ! enteric nervous system development GO:0048484 8 5 0,000 0,01384981 0,09046817 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01384981 0,09022692 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01384981 0,08998696 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01384981 0,08974826 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01384981 0,08951083 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01384981 0,08927466 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01384981 0,08903973 ! B cell homeostasis GO:0001782 13 5 0,000 0,01384981 0,08880603 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01384981 0,08857355 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01384981 0,08834229 ! metaphase GO:0051323 11 5 0,000 0,01384981 0,08811223 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01384981 0,08788337 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01384981 0,08765569 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01384981 0,08742919 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01384981 0,08720385 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01384981 0,08697968 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01384981 0,08675666 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01384981 0,08653477 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01384981 0,08631402 ! response to redox state GO:0051775 6 5 0,000 0,01384981 0,08609439 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01384981 0,08587588 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01384981 0,08565847 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01384981 0,08544216 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01384981 0,08522694 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01384981 0,0850128 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01384981 0,08479974 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01384981 0,08458774 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01384981 0,0843768 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01384981 0,0841669 ! striatum development GO:0021756 14 5 0,000 0,01384981 0,08395805 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01384981 0,08375024 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01384981 0,08354345 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01384981 0,08333767 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01384981 0,08313291 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01384981 0,08292916 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01384981 0,0827264 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01384981 0,08252462 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01384981 0,08232383 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01384981 0,08212402 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01384981 0,08192517 ! neuroprotection GO:0043526 8 5 0,000 0,01384981 0,08172728 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01384981 0,08153035 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01384981 0,08133436 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01384981 0,08113932 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01384981 0,0809452 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01384981 0,08075202 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01384981 0,08055975 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01384981 0,0803684 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01384981 0,08017795 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01384981 0,07998841 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01384981 0,07979975 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01384981 0,07961199 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01384981 0,07942511 ! spindle assembly GO:0051225 6 5 0,000 0,01384981 0,0792391 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01384981 0,07905396 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01384981 0,07886969 ! protein palmitoylation GO:0018345 12 5 0,000 0,01384981 0,07868627 ! drug metabolic process GO:0017144 7 5 0,000 0,01384981 0,0785037 ! stem cell division GO:0017145 11 5 0,000 0,01384981 0,07832198 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01384981 0,0781411 ! organ regeneration GO:0031100 7 5 0,000 0,01384981 0,07796105 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01384981 0,07778183 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01384981 0,07760343 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,01425282 0,07967881 GO:0048609|reproductive process in a multicellular organism, ! positive regulation of cell motion GO:0051272 157 65 1,000 0,01425282 0,0794969 ! gonad development GO:0008406 115 66 1,000 0,01467183 0,08164758 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,01509613 0,08381782 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,01509613 0,08362776 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 1,000 0,01509613 0,08343855 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,01552567 0,08561901 ! extracellular matrix organization GO:0030198 146 68 1,000 0,01552567 0,08542617 ! viral reproduction GO:0016032 142 68 1,000 0,01552567 0,08523421 ! regulation of lipase activity GO:0060191 137 68 1,000 0,01552567 0,0850431 ! negative regulation of cell size GO:0045792 144 69 1,000 0,01596044 0,08722898 ! negative regulation of protein kinase activity GO:0006469 144 69 1,000 0,01596044 0,08703427 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,01596044 0,08684043 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,01596044 0,08664745 ! developmental maturation GO:0021700 128 69 1,000 0,01596044 0,08645533 ! negative regulation of kinase activity GO:0033673 145 70 1,000 0,01640039 0,08864194 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01659691 0,08950605 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01659691 0,0893089 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01659691 0,08911261 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01659691 0,08891719 GO:0030816|positive regulation of cAMP metabolic process, ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01659691 0,08872262 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01659691 0,08852891 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01659691 0,08833603 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01659691 0,088144 ! response to oxygen radical GO:0000305 11 6 0,000 0,01659691 0,0879528 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01659691 0,08776242 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01659691 0,08757287 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01659691 0,08738414 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01659691 0,08719621 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01659691 0,0870091 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01659691 0,08682278 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01659691 0,08663726 ! forebrain regionalization GO:0021871 9 6 0,000 0,01659691 0,08645254 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01659691 0,08626859 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01659691 0,08608543 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01659691 0,08590305 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01659691 0,08572144 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01659691 0,08554059 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01659691 0,0853605 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01659691 0,08518117 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01659691 0,0850026 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01659691 0,08482477 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01659691 0,08464768 ! malate metabolic process GO:0006108 13 6 0,000 0,01659691 0,08447133 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01659691 0,08429572 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01659691 0,08412083 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01659691 0,08394666 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01659691 0,08377322 ! protein refolding GO:0042026 15 6 0,000 0,01659691 0,08360049 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01659691 0,08342848 ! opsonization GO:0008228 8 6 0,000 0,01659691 0,08325716 ! mating behavior GO:0007617 7 6 0,000 0,01659691 0,08308656 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01659691 0,08291664 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01659691 0,08274743 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01659691 0,0825789 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01659691 0,08241105 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01659691 0,08224389 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01659691 0,08207741 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01659691 0,08191159 ! toxin metabolic process GO:0009404 11 6 0,000 0,01659691 0,08174645 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01659691 0,08158197 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01659691 0,08141815 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01659691 0,08125499 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01659691 0,08109248 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01659691 0,08093062 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01659691 0,0807694 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01659691 0,08060882 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01659691 0,08044889 ! thymic T cell selection GO:0045061 16 6 0,000 0,01659691 0,08028958 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01659691 0,08013091 ! protein lipoylation GO:0009249 10 6 0,000 0,01659691 0,07997286 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01659691 0,07981543 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01659691 0,07965862 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01659691 0,07950243 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01659691 0,07934685 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01659691 0,07919187 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01659691 0,0790375 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01659691 0,07888373 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01659691 0,07873056 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01659691 0,07857798 ! hyperosmotic response GO:0006972 10 6 0,000 0,01659691 0,07842599 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01659691 0,07827459 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01659691 0,07812377 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01659691 0,07797354 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01659691 0,07782388 ! urea metabolic process GO:0019627 7 6 0,000 0,01659691 0,07767479 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01659691 0,07752627 ! neutrophil activation GO:0042119 7 6 0,000 0,01659691 0,07737832 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01659691 0,07723093 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01659691 0,0770841 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01659691 0,07693783 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01659691 0,07679212 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01659691 0,07664695 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01659691 0,07650234 ! neuron apoptosis GO:0051402 15 6 0,000 0,01659691 0,07635827 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01659691 0,07621473 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01659691 0,07607174 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01659691 0,07592929 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01659691 0,07578736 ! carnitine transport GO:0015879 10 6 0,000 0,01659691 0,07564597 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01659691 0,0755051 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01659691 0,07536476 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01659691 0,07522493 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01659691 0,07508563 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01659691 0,07494684 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01659691 0,07480856 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01659691 0,07467079 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01659691 0,07453353 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01659691 0,07439677 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01659691 0,07426051 ! neural nucleus development GO:0048857 19 6 0,000 0,01659691 0,07412475 ! response to UV-C GO:0010225 14 6 0,000 0,01659691 0,07398949 ! astrocyte development GO:0014002 16 6 0,000 0,01659691 0,07385472 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01659691 0,07372043 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01659691 0,07358664 ! interaction with symbiont GO:0051702 14 6 0,000 0,01659691 0,07345333 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01659691 0,0733205 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01659691 0,07318816 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01659691 0,07305629 ! response to copper ion GO:0046688 10 6 0,000 0,01659691 0,07292489 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01659691 0,07279397 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01659691 0,07266351 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01659691 0,07253352 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01659691 0,072404 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01659691 0,07227494 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01659691 0,07214633 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01659691 0,07201819 ! hair follicle maturation GO:0048820 8 6 0,000 0,01659691 0,07189049 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01659691 0,07176325 ! Schwann cell development GO:0014044 15 6 0,000 0,01659691 0,07163646 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01659691 0,07151012 ! response to pheromone GO:0019236 6 6 0,000 0,01659691 0,07138422 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01659691 0,07125877 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01659691 0,07113375 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01659691 0,07100918 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01659691 0,07088503 ! subpallium development GO:0021544 15 6 0,000 0,01659691 0,07076132 ! neural tube patterning GO:0021532 8 6 0,000 0,01659691 0,07063805 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01659691 0,0705152 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01659691 0,07039278 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01659691 0,07027078 ! G2 phase GO:0051319 16 6 0,000 0,01659691 0,0701492 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01659691 0,07002805 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01659691 0,06990731 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01659691 0,06978699 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01659691 0,06966708 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01659691 0,06954758 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01659691 0,06942849 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01659691 0,06930981 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01659691 0,06919153 ! receptor internalization GO:0031623 11 6 0,000 0,01659691 0,06907366 ! plasminogen activation GO:0031639 9 6 0,000 0,01659691 0,06895619 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01659691 0,06883912 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01659691 0,06872244 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01659691 0,06860616 ! protein deubiquitination GO:0016579 16 6 0,000 0,01659691 0,06849027 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,01659691 0,06837477 ! protein destabilization GO:0031648 9 6 0,000 0,01659691 0,06825966 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01659691 0,06814494 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01659691 0,0680306 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01659691 0,06791665 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01659691 0,06780308 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01659691 0,06768988 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01659691 0,06757706 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01659691 0,06746462 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01659691 0,06735256 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01659691 0,06724086 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01659691 0,06712953 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01659691 0,06701858 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01659691 0,06690799 ! neural plate development GO:0001840 9 6 0,000 0,01659691 0,06679776 ! catecholamine transport GO:0051937 9 6 0,000 0,01659691 0,06668789 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01659691 0,06657839 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01659691 0,06646924 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01659691 0,06636046 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01659691 0,06625202 ! maternal placenta development GO:0001893 12 6 0,000 0,01659691 0,06614395 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01659691 0,06603622 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01659691 0,06592884 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01659691 0,06582182 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01659691 0,06571514 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01659691 0,0656088 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01659691 0,06550281 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01659691 0,06539716 GO:0055081|anion homeostasis, ! appendage morphogenesis GO:0035107 150 72 1,000 0,01729573 0,06804102 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 151 73 1,000 0,01775106 0,06971999 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 1,000 0,01775106 0,06960808 ! negative regulation of transferase activity GO:0051348 155 74 1,000 0,01821144 0,07129897 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,01867686 0,07300411 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 143 75 1,000 0,01867686 0,07288749 ! reproductive structure development GO:0048608 131 75 1,000 0,01867686 0,07277124 ! axon guidance GO:0007411 162 75 1,000 0,01867686 0,07265537 ! rhythmic process GO:0048511 142 75 1,000 0,01867686 0,07253986 ! tRNA transcription GO:0009304 17 7 0,000 0,01933642 0,07498234 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,01933642 0,07486351 GO:0045346|regulation of MHC class II biosynthetic process, ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01933642 0,07474506 ! regulation of helicase activity GO:0051095 16 7 0,000 0,01933642 0,07462698 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,01933642 0,07450927 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,01933642 0,07439193 ! sleep GO:0030431 16 7 0,000 0,01933642 0,07427496 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01933642 0,07415836 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,01933642 0,07404212 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01933642 0,07392625 ! prostate gland development GO:0030850 14 7 0,000 0,01933642 0,07381074 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,01933642 0,07369559 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01933642 0,0735808 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01933642 0,07346637 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,01933642 0,07335229 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01933642 0,07323857 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,01933642 0,07312519 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,01933642 0,07301217 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01933642 0,0728995 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,01933642 0,07278717 ! glycolipid transport GO:0046836 11 7 0,000 0,01933642 0,07267519 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01933642 0,07256356 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,01933642 0,07245226 ! neuron adhesion GO:0007158 14 7 0,000 0,01933642 0,07234131 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,01933642 0,0722307 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,01933642 0,07212042 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,01933642 0,07201048 ! mRNA stabilization GO:0048255 18 7 0,000 0,01933642 0,07190088 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,01933642 0,0717916 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,01933642 0,07168266 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,01933642 0,07157405 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,01933642 0,07146577 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,01933642 0,07135782 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01933642 0,07125019 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01933642 0,07114289 ! lipoprotein transport GO:0042953 14 7 0,000 0,01933642 0,0710359 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,01933642 0,07092924 ! rhythmic behavior GO:0007622 17 7 0,000 0,01933642 0,0708229 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,01933642 0,07071688 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,01933642 0,07061117 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,01933642 0,07050578 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,01933642 0,07040071 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01933642 0,07029595 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,01933642 0,07019149 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01933642 0,07008735 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,01933642 0,06998352 ! mechanosensory behavior GO:0007638 16 7 0,000 0,01933642 0,06987999 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,01933642 0,06977677 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,01933642 0,06967386 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,01933642 0,06957125 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,01933642 0,06946893 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01933642 0,06936692 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01933642 0,06926521 ! spinal cord patterning GO:0021511 14 7 0,000 0,01933642 0,0691638 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,01933642 0,06906268 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,01933642 0,06896186 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01933642 0,06886133 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,01933642 0,0687611 ! adrenal gland development GO:0030325 17 7 0,000 0,01933642 0,06866116 ! cysteine metabolic process GO:0006534 13 7 0,000 0,01933642 0,0685615 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,01933642 0,06846214 ! ovulation GO:0030728 10 7 0,000 0,01933642 0,06836306 ! adenohypophysis development GO:0021984 11 7 0,000 0,01933642 0,06826427 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,01933642 0,06816577 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,01933642 0,06806754 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,01933642 0,06796961 ! microtubule nucleation GO:0007020 21 7 0,000 0,01933642 0,06787195 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01933642 0,06777457 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,01933642 0,06767747 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01933642 0,06758065 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,01933642 0,06748411 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,01933642 0,06738784 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01933642 0,06729185 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,01933642 0,06719612 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,01933642 0,06710068 ! galactose metabolic process GO:0006012 13 7 0,000 0,01933642 0,0670055 ! vesicle fusion GO:0006906 20 7 0,000 0,01933642 0,06691059 ! response to dietary excess GO:0002021 8 7 0,000 0,01933642 0,06681595 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01933642 0,06672158 ! intracellular pH reduction GO:0051452 13 7 0,000 0,01933642 0,06662747 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01933642 0,06653363 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,01933642 0,06644005 ! organ growth GO:0035265 15 7 0,000 0,01933642 0,06634674 ! nucleoside transport GO:0015858 11 7 0,000 0,01933642 0,06625368 ! nucleoside salvage GO:0043174 11 7 0,000 0,01933642 0,06616089 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,01933642 0,06606836 ! male sex determination GO:0030238 15 7 0,000 0,01933642 0,06597608 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,01933642 0,06588407 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,01933642 0,06579231 ! parturition GO:0007567 16 7 0,000 0,01933642 0,0657008 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,01933642 0,06560955 ! rRNA modification GO:0000154 14 7 0,000 0,01933642 0,06551855 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,01933642 0,06542781 ! spindle checkpoint GO:0031577 16 7 0,000 0,01933642 0,06533731 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,01933642 0,06524707 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,01933642 0,06515707 ! monocyte differentiation GO:0030224 16 7 0,000 0,01933642 0,06506732 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,01933642 0,06497782 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01933642 0,06488857 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,01933642 0,06479956 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,01933642 0,06471079 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,01933642 0,06462226 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01933642 0,06453398 ! fibrinolysis GO:0042730 11 7 0,000 0,01933642 0,06444594 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,01933642 0,06435814 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,01933642 0,06427058 ! eating behavior GO:0042755 8 7 0,000 0,01933642 0,06418325 ! B cell lineage commitment GO:0002326 21 7 0,000 0,01933642 0,06409617 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01933642 0,06400932 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,01933642 0,0639227 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,01933642 0,06383632 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,01933642 0,06375017 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01933642 0,06366425 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,01933642 0,06357857 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,01933642 0,06349311 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,01933642 0,06340789 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,01933642 0,06332289 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01933642 0,06323812 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,01933642 0,06315358 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,01933642 0,06306926 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01933642 0,06298517 ! histone ubiquitination GO:0016574 9 7 0,000 0,01933642 0,0629013 ! regulation of meiosis GO:0040020 12 7 0,000 0,01933642 0,06281765 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,01933642 0,06273423 ! T cell lineage commitment GO:0002360 16 7 0,000 0,01933642 0,06265103 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,01933642 0,06256805 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01933642 0,06248529 ! membrane to membrane docking GO:0022614 14 7 0,000 0,01933642 0,06240274 ! transcription termination GO:0006353 14 7 0,000 0,01933642 0,06232042 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01933642 0,06223831 ! anaphase GO:0051322 18 7 0,000 0,01933642 0,06215642 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,01933642 0,06207474 ! axonal fasciculation GO:0007413 19 7 0,000 0,01933642 0,06199328 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,01933642 0,06191203 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,01933642 0,06183099 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,01933642 0,06175016 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,01933642 0,06166955 ! diuresis GO:0030146 12 7 0,000 0,01933642 0,06158915 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01933642 0,06150895 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01933642 0,06142897 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01933642 0,06134919 ! antibiotic transport GO:0042891 9 7 0,000 0,01933642 0,06126962 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01933642 0,06119025 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,01933642 0,06111109 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,01933642 0,06103214 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,01933642 0,06095339 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,01933642 0,06087484 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,01933642 0,06079649 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,01933642 0,06071835 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01933642 0,06064041 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01933642 0,06056266 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,01933642 0,06048512 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,01933642 0,06040777 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,01933642 0,06033062 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,01933642 0,06025367 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,01933642 0,06017691 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,01933642 0,06010035 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,01933642 0,06002398 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,01933642 0,05994781 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,01933642 0,05987183 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01933642 0,05979605 ! muscle adaptation GO:0043500 13 7 0,000 0,01933642 0,05972045 ! embryonic heart tube development GO:0035050 14 7 0,000 0,01933642 0,05964505 ! retina homeostasis GO:0001895 12 7 0,000 0,01933642 0,05956983 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,01933642 0,05949481 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,01933642 0,05941997 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,01933642 0,05934532 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,01933642 0,05927086 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,01962266 0,06007289 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,02107832 0,06444848 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,02107832 0,06436792 ! muscle cell differentiation GO:0042692 178 81 1,000 0,02157327 0,06579714 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,02157327 0,0657151 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02206838 0,06713955 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02206838 0,06705604 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02206838 0,06697274 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02206838 0,06688965 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02206838 0,06680676 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02206838 0,06672408 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02206838 0,0666416 ! male meiosis GO:0007140 9 8 0,000 0,02206838 0,06655933 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02206838 0,06647726 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02206838 0,06639539 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02206838 0,06631372 ! meiotic prophase I GO:0007128 14 8 0,000 0,02206838 0,06623226 ! response to zinc ion GO:0010043 12 8 0,000 0,02206838 0,06615099 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02206838 0,06606992 ! oligopeptide transport GO:0006857 16 8 0,000 0,02206838 0,06598905 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02206838 0,06590838 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02206838 0,06582791 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02206838 0,06574763 ! signal peptide processing GO:0006465 12 8 0,000 0,02206838 0,06566755 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02206838 0,06558766 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02206838 0,06550797 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02206838 0,06542847 ! succinate metabolic process GO:0006105 17 8 0,000 0,02206838 0,06534916 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02206838 0,06527004 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02206838 0,06519112 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02206838 0,06511239 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02206838 0,06503384 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02206838 0,06495549 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,02206838 0,06487732 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02206838 0,06479935 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02206838 0,06472156 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02206838 0,06464395 ! reflex GO:0060004 17 8 0,000 0,02206838 0,06456653 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02206838 0,0644893 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02206838 0,06441225 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02206838 0,06433539 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02206838 0,06425871 ! pigment granule organization GO:0048753 17 8 0,000 0,02206838 0,06418221 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,02206838 0,06410589 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02206838 0,06402976 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02206838 0,0639538 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02206838 0,06387803 ! histidine catabolic process GO:0006548 10 8 0,000 0,02206838 0,06380243 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02206838 0,06372702 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02206838 0,06365178 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02206838 0,06357672 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,02206838 0,06350183 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02206838 0,06342712 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02206838 0,06335259 ! melanin metabolic process GO:0006582 17 8 0,000 0,02206838 0,06327823 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02206838 0,06320405 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02206838 0,06313004 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02206838 0,06305621 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,02206838 0,06298254 ! macrophage activation GO:0042116 13 8 0,000 0,02206838 0,06290905 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02206838 0,06283573 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02206838 0,06276258 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02206838 0,0626896 ! purine salvage GO:0043101 12 8 0,000 0,02206838 0,06261679 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02206838 0,06254415 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02206838 0,06247168 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02206838 0,06239937 ! osteoblast development GO:0002076 17 8 0,000 0,02206838 0,06232723 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02206838 0,06225526 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02206838 0,06218346 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02206838 0,06211182 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02206838 0,06204034 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02206838 0,06196903 ! response to UV-B GO:0010224 17 8 0,000 0,02206838 0,06189788 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02206838 0,0618269 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02206838 0,06175608 ! intermediate filament organization GO:0045109 12 8 0,000 0,02206838 0,06168542 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02206838 0,06161492 ! cellular extravasation GO:0045123 13 8 0,000 0,02206838 0,06154458 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02206838 0,06147441 ! response to antibiotic GO:0046677 11 8 0,000 0,02206838 0,06140439 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02206838 0,06133453 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02206838 0,06126484 ! DNA topological change GO:0006265 12 8 0,000 0,02206838 0,0611953 ! response to tropane GO:0014073 15 8 0,000 0,02206838 0,06112591 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,02206838 0,06105669 ! melanosome transport GO:0032402 13 8 0,000 0,02206838 0,06098762 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02206838 0,06091871 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02206838 0,06084995 ! mast cell activation GO:0045576 14 8 0,000 0,02206838 0,06078135 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02206838 0,0607129 ! gas homeostasis GO:0033483 14 8 0,000 0,02206838 0,06064461 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02206838 0,06057647 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02206838 0,06050848 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02206838 0,06044065 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02206838 0,06037296 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02206838 0,06030543 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02206838 0,06023805 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02206838 0,06017082 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02206838 0,06010374 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02206838 0,06003681 ! response to tumor cell GO:0002347 16 8 0,000 0,02206838 0,05997003 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02206838 0,0599034 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,02206838 0,05983691 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02206838 0,05977057 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02206838 0,05970438 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02206838 0,05963834 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02206838 0,05957244 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02206838 0,05950668 ! hormone catabolic process GO:0042447 17 8 0,000 0,02206838 0,05944108 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02206838 0,05937561 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02206838 0,05931029 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02206838 0,05924512 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02206838 0,05918008 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02206838 0,05911519 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02206838 0,05905044 ! adult feeding behavior GO:0008343 10 8 0,000 0,02206838 0,05898584 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02206838 0,05892137 ! ATP catabolic process GO:0006200 11 8 0,000 0,02206838 0,05885705 ! blastocyst growth GO:0001832 19 8 0,000 0,02206838 0,05879286 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02206838 0,05872882 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02206838 0,05866491 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02206838 0,05860115 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02206838 0,05853752 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02206838 0,05847403 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02206838 0,05841068 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02206838 0,05834746 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02206838 0,05828438 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02206838 0,05822144 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02206838 0,05815864 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02206838 0,05809597 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02206838 0,05803343 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02206838 0,05797103 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02206838 0,05790876 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02206838 0,05784663 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02206838 0,05778463 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,02206838 0,05772276 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02206838 0,05766102 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02206838 0,05759942 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02206838 0,05753795 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,0225776 0,05880285 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of growth GO:0045926 168 85 1,000 0,02360095 0,06140268 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,02360095 0,06133736 ! cellular response to hormone stimulus GO:0032870 182 85 1,000 0,02360095 0,06127217 ! axon extension GO:0048675 16 9 0,000 0,02479281 0,06429812 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,02479281 0,06422994 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02479281 0,0641619 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,02479281 0,064094 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02479281 0,06402625 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,02479281 0,06395864 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,02479281 0,06389117 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02479281 0,06382385 ! reproductive behavior GO:0019098 22 9 0,000 0,02479281 0,06375666 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02479281 0,06368962 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,02479281 0,06362272 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02479281 0,06355596 ! UTP metabolic process GO:0046051 10 9 0,000 0,02479281 0,06348934 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02479281 0,06342286 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,02479281 0,06335652 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02479281 0,06329031 ! artery development GO:0060840 25 9 0,000 0,02479281 0,06322425 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02479281 0,06315832 ! regulation of glycolysis GO:0006110 20 9 0,000 0,02479281 0,06309253 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,02479281 0,06302688 ! equilibrioception GO:0050957 20 9 0,000 0,02479281 0,06296136 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,02479281 0,06289598 ! chemosensory behavior GO:0007635 21 9 0,000 0,02479281 0,06283074 ! microtubule bundle formation GO:0001578 22 9 0,000 0,02479281 0,06276563 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,02479281 0,06270065 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02479281 0,06263581 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02479281 0,06257111 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02479281 0,06250653 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02479281 0,06244209 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02479281 0,06237779 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02479281 0,06231361 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02479281 0,06224957 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02479281 0,06218566 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02479281 0,06212188 ! protein targeting to ER GO:0045047 25 9 0,000 0,02479281 0,06205823 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02479281 0,06199471 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02479281 0,06193132 ! T cell selection GO:0045058 27 9 0,000 0,02479281 0,06186806 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02479281 0,06180493 ! glycine catabolic process GO:0006546 15 9 0,000 0,02479281 0,06174193 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,02479281 0,06167905 ! endosome organization GO:0007032 20 9 0,000 0,02479281 0,06161631 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02479281 0,06155369 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,02479281 0,0614912 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02479281 0,06142883 ! mannose metabolic process GO:0006013 13 9 0,000 0,02479281 0,0613666 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02479281 0,06130448 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02479281 0,0612425 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,02479281 0,06118064 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02479281 0,0611189 ! receptor clustering GO:0043113 20 9 0,000 0,02479281 0,06105729 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02479281 0,0609958 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02479281 0,06093444 ! retinol metabolic process GO:0042572 20 9 0,000 0,02479281 0,0608732 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02479281 0,06081208 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02479281 0,06075108 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02479281 0,06069021 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02479281 0,06062946 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02479281 0,06056883 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02479281 0,06050832 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02479281 0,06044793 ! response to amine stimulus GO:0014075 13 9 0,000 0,02479281 0,06038767 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02479281 0,06032752 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02479281 0,06026749 ! erythrocyte development GO:0048821 17 9 0,000 0,02479281 0,06020759 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02479281 0,0601478 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02479281 0,06008813 ! renal water homeostasis GO:0003091 15 9 0,000 0,02479281 0,06002857 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02479281 0,05996914 ! icosanoid secretion GO:0032309 15 9 0,000 0,02479281 0,05990982 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02479281 0,05985062 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02479281 0,05979154 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02479281 0,05973257 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02479281 0,05967372 ! sterol catabolic process GO:0016127 14 9 0,000 0,02479281 0,05961499 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02479281 0,05955637 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02479281 0,05949787 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,02479281 0,05943948 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02479281 0,05938121 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,02479281 0,05932305 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02479281 0,059265 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02479281 0,05920707 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,02479281 0,05914925 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,02479281 0,05909154 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02479281 0,05903395 ! purine base metabolic process GO:0006144 25 9 0,000 0,02479281 0,05897647 ! pigment granule transport GO:0051904 17 9 0,000 0,02479281 0,0589191 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,02479281 0,05886184 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02479281 0,05880469 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02479281 0,05874765 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02479281 0,05869073 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02479281 0,05863391 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02479281 0,05857721 ! mitochondrion localization GO:0051646 18 9 0,000 0,02479281 0,05852061 ! regulation of DNA binding GO:0051101 167 89 1,000 0,02570377 0,06061227 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,026241 0,06181943 ! regulation of cell cycle process GO:0010564 161 90 1,000 0,026241 0,06175988 ! defense response to bacterium GO:0042742 112 91 1,000 0,02678277 0,06297431 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,02732907 0,06419703 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02750972 0,06455932 ! regulation of developmental growth GO:0048638 16 10 0,000 0,02750972 0,06449736 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,02750972 0,06443552 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02750972 0,0643738 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02750972 0,0643122 ! associative learning GO:0008306 21 10 0,000 0,02750972 0,06425072 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,02750972 0,06418935 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02750972 0,0641281 ! phosphate transport GO:0006817 24 10 0,000 0,02750972 0,06406697 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02750972 0,06400595 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02750972 0,06394505 ! CTP metabolic process GO:0046036 11 10 0,000 0,02750972 0,06388427 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02750972 0,0638236 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02750972 0,06376305 ! GTP metabolic process GO:0046039 11 10 0,000 0,02750972 0,06370261 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02750972 0,06364228 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02750972 0,06358207 ! social behavior GO:0035176 29 10 0,000 0,02750972 0,06352198 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02750972 0,06346199 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,02750972 0,06340212 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02750972 0,06334237 ! androgen metabolic process GO:0008209 17 10 0,000 0,02750972 0,06328272 ! phospholipid efflux GO:0033700 19 10 0,000 0,02750972 0,06322319 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02750972 0,06316377 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02750972 0,06310446 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02750972 0,06304526 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02750972 0,06298618 ! lung alveolus development GO:0048286 26 10 0,000 0,02750972 0,0629272 ! pathogenesis GO:0009405 17 10 0,000 0,02750972 0,06286833 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02750972 0,06280958 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02750972 0,06275093 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02750972 0,0626924 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,02750972 0,06263397 ! endoderm development GO:0007492 18 10 0,000 0,02750972 0,06257565 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02750972 0,06251744 ! arginine catabolic process GO:0006527 17 10 0,000 0,02750972 0,06245934 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02750972 0,06240135 ! proline metabolic process GO:0006560 13 10 0,000 0,02750972 0,06234346 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02750972 0,06228568 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02750972 0,06222801 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02750972 0,06217044 ! V(D)J recombination GO:0033151 34 10 0,000 0,02750972 0,06211299 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02750972 0,06205563 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,02750972 0,06199839 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02750972 0,06194124 ! B cell proliferation GO:0042100 19 10 0,000 0,02750972 0,06188421 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02750972 0,06182728 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02750972 0,06177045 ! multicellular organism growth GO:0035264 19 10 0,000 0,02750972 0,06171373 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02750972 0,06165711 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02750972 0,0616006 ! ruffle organization GO:0031529 17 10 0,000 0,02750972 0,06154418 ! epithelial cell development GO:0002064 21 10 0,000 0,02750972 0,06148788 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02750972 0,06143167 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02750972 0,06137557 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02750972 0,06131957 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02750972 0,06126367 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02750972 0,06120788 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02750972 0,06115218 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,02750972 0,06109659 ! copper ion homeostasis GO:0055070 13 10 0,000 0,02750972 0,0610411 ! regulation of bone resorption GO:0045124 25 10 0,000 0,02750972 0,06098571 ! protein heterooligomerization GO:0051291 17 10 0,000 0,02750972 0,06093042 ! brain morphogenesis GO:0048854 23 10 0,000 0,02750972 0,06087523 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02750972 0,06082014 ! segment specification GO:0007379 15 10 0,000 0,02750972 0,06076514 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02750972 0,06071025 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02750972 0,06065546 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02750972 0,06060077 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02750972 0,06054617 ! response to dsRNA GO:0043331 23 10 0,000 0,02750972 0,06049167 ! DNA ligation GO:0006266 18 10 0,000 0,02750972 0,06043727 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02750972 0,06038297 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02750972 0,06032877 ! melanosome localization GO:0032400 16 10 0,000 0,02750972 0,06027466 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02750972 0,06022065 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02750972 0,06016674 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,02750972 0,06011292 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02750972 0,0600592 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02750972 0,06000558 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02750972 0,05995205 ! protein sumoylation GO:0016925 17 10 0,000 0,02750972 0,05989862 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02750972 0,05984528 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02750972 0,05979204 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02750972 0,05973889 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02750972 0,05968583 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02750972 0,05963287 ! salivary gland development GO:0007431 28 10 0,000 0,02750972 0,05958001 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02750972 0,05952724 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02750972 0,05947456 ! midbrain development GO:0030901 14 10 0,000 0,02750972 0,05942197 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02750972 0,05936948 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02750972 0,05931708 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02750972 0,05926477 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02750972 0,05921255 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02750972 0,05916043 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02750972 0,0591084 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02750972 0,05905646 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02750972 0,05900461 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02750972 0,05895285 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,02750972 0,05890118 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,02750972 0,05884961 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02750972 0,05879812 ! blastocyst formation GO:0001825 18 10 0,000 0,02750972 0,05874672 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02750972 0,05869541 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02750972 0,0586442 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02750972 0,05859307 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02750972 0,05854203 ! response to nicotine GO:0035094 20 10 0,000 0,02750972 0,05849108 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02750972 0,05844022 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,02750972 0,05838944 ! positive regulation of MAP kinase activity GO:0043406 174 93 1,000 0,02787986 0,05912369 ! sex differentiation GO:0007548 171 96 1,000 0,02955889 0,06262998 ! regulation of DNA metabolic process GO:0051052 188 97 1,000 0,03012736 0,06377916 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,03021914 0,06391806 ! respiratory burst GO:0045730 17 11 0,000 0,03021914 0,06386277 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,03021914 0,06380757 ! neuron fate specification GO:0048665 18 11 0,000 0,03021914 0,06375247 ! telencephalon cell migration GO:0022029 23 11 0,000 0,03021914 0,06369747 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,03021914 0,06364255 ! thyroid gland development GO:0030878 26 11 0,000 0,03021914 0,06358774 ! synapsis GO:0007129 14 11 0,000 0,03021914 0,06353301 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,03021914 0,06347839 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,03021914 0,06342385 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,03021914 0,06336941 ! response to pain GO:0048265 27 11 0,000 0,03021914 0,06331506 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,03021914 0,06326081 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,03021914 0,06320665 ! blood vessel remodeling GO:0001974 30 11 0,000 0,03021914 0,06315258 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,03021914 0,0630986 ! bone resorption GO:0045453 16 11 0,000 0,03021914 0,06304472 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,03021914 0,06299092 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,03021914 0,06293722 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,03021914 0,06288361 ! melanocyte differentiation GO:0030318 20 11 0,000 0,03021914 0,0628301 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,03021914 0,06277667 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,03021914 0,06272333 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,03021914 0,06267009 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,03021914 0,06261693 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,03021914 0,06256387 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,03021914 0,06251089 ! UV protection GO:0009650 20 11 0,000 0,03021914 0,06245801 ! adult heart development GO:0007512 16 11 0,000 0,03021914 0,06240521 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,03021914 0,0623525 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,03021914 0,06229988 ! macroautophagy GO:0016236 19 11 0,000 0,03021914 0,06224736 ! temperature homeostasis GO:0001659 18 11 0,000 0,03021914 0,06219491 ! behavioral fear response GO:0001662 27 11 0,000 0,03021914 0,06214256 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,03021914 0,0620903 ! negative regulation of ossification GO:0030279 27 11 0,000 0,03021914 0,06203812 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,03021914 0,06198603 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,03021914 0,06193403 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,03021914 0,06188212 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,03021914 0,06183029 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,03021914 0,06177855 ! regulation of organ growth GO:0046620 14 11 0,000 0,03021914 0,06172689 ! pigment granule localization GO:0051875 20 11 0,000 0,03021914 0,06167532 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,03021914 0,06162384 ! vasoconstriction GO:0042310 20 11 0,000 0,03021914 0,06157245 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,03021914 0,06152114 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,03021914 0,06146991 ! embryonic axis specification GO:0000578 19 11 0,000 0,03021914 0,06141877 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,03021914 0,06136772 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,03021914 0,06131675 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,03021914 0,06126586 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,03021914 0,06121506 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,03021914 0,06116434 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,03021914 0,06111371 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,03021914 0,06106316 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,03021914 0,0610127 ! prophase GO:0051324 17 11 0,000 0,03021914 0,06096231 ! nucleosome positioning GO:0016584 15 11 0,000 0,03021914 0,06091202 ! regulation of isotype switching GO:0045191 24 11 0,000 0,03021914 0,0608618 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,03021914 0,06081167 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,03021914 0,06076162 ! apical protein localization GO:0045176 18 11 0,000 0,03021914 0,06071165 ! acid secretion GO:0046717 20 11 0,000 0,03021914 0,06066176 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,03021914 0,06061196 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,03021914 0,06056223 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,03021914 0,06051259 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,03021914 0,06046303 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,03021914 0,06041355 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,03021914 0,06036416 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,03021914 0,06031484 ! cholesterol efflux GO:0033344 21 11 0,000 0,03021914 0,0602656 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,03021914 0,06021645 ! oocyte development GO:0048599 20 11 0,000 0,03021914 0,06016737 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,03021914 0,06011837 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,03021914 0,06006946 ! embryonic gut development GO:0048566 19 11 0,000 0,03021914 0,06002062 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,03021914 0,05997186 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,03021914 0,05992318 ! activation of innate immune response GO:0002218 16 11 0,000 0,03021914 0,05987459 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,03021914 0,05982606 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,03021914 0,05977762 ! lysogeny GO:0030069 22 11 0,000 0,03021914 0,05972926 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,03021914 0,05968097 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,03021914 0,05963277 ! sequestering of metal ion GO:0051238 15 11 0,000 0,03021914 0,05958464 ! regulation of embryonic development GO:0045995 35 11 0,000 0,03021914 0,05953658 ! forebrain development GO:0030900 210 98 1,000 0,03070018 0,06043558 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,03185876 0,06266583 GO:0060538|skeletal muscle organ development, ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,03292109 0,06470332 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,03292109 0,0646513 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,03292109 0,06459937 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,03292109 0,06454753 ! virus-host interaction GO:0019048 30 12 0,000 0,03292109 0,06449577 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,03292109 0,06444409 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,03292109 0,06439249 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,03292109 0,06434098 ! protein complex disassembly GO:0043241 28 12 0,000 0,03292109 0,06428955 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,03292109 0,0642382 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,03292109 0,06418693 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,03292109 0,06413574 ! T cell proliferation GO:0042098 32 12 0,000 0,03292109 0,06408464 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,03292109 0,06403362 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,03292109 0,06398267 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,03292109 0,06393181 ! drug transport GO:0015893 16 12 0,000 0,03292109 0,06388103 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,03292109 0,06383033 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,03292109 0,06377972 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,03292109 0,06372918 ! polyamine metabolic process GO:0006595 18 12 0,000 0,03292109 0,06367872 ! focal adhesion formation GO:0048041 37 12 0,000 0,03292109 0,06362834 ! mitotic spindle organization GO:0007052 23 12 0,000 0,03292109 0,06357804 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,03292109 0,06352782 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,03292109 0,06347768 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,03292109 0,06342762 ! lipid digestion GO:0044241 21 12 0,000 0,03292109 0,06337764 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,03292109 0,06332773 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03292109 0,06327791 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,03292109 0,06322816 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,03292109 0,06317849 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,03292109 0,0631289 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,03292109 0,06307939 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,03292109 0,06302995 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,03292109 0,0629806 ! snRNA metabolic process GO:0016073 30 12 0,000 0,03292109 0,06293132 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,03292109 0,06288211 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,03292109 0,06283299 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,03292109 0,06278394 ! cranial nerve development GO:0021545 23 12 0,000 0,03292109 0,06273496 ! fucose catabolic process GO:0019317 25 12 0,000 0,03292109 0,06268607 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,03292109 0,06263724 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,03292109 0,0625885 ! autonomic nervous system development GO:0048483 24 12 0,000 0,03292109 0,06253983 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,03292109 0,06249124 ! T cell homeostasis GO:0043029 28 12 0,000 0,03292109 0,06244272 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,03292109 0,06239428 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,03292109 0,06234591 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,03292109 0,06229762 ! oocyte differentiation GO:0009994 21 12 0,000 0,03292109 0,0622494 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,03292109 0,06220125 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,03292109 0,06215319 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,03292109 0,06210519 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,03292109 0,06205727 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,03292109 0,06200942 ! defense response to fungus GO:0050832 15 12 0,000 0,03292109 0,06196165 ! embryonic placenta development GO:0001892 21 12 0,000 0,03292109 0,06191395 ! lamellipodium assembly GO:0030032 24 12 0,000 0,03292109 0,06186632 ! response to cold GO:0009409 17 12 0,000 0,03292109 0,06181877 ! establishment of cell polarity GO:0030010 21 12 0,000 0,03292109 0,06177129 ! regulation of synapse organization GO:0050807 18 12 0,000 0,03292109 0,06172388 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,03561558 0,0667246 ! cGMP metabolic process GO:0046068 18 13 0,000 0,03561558 0,06667347 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,03561558 0,06662241 ! regulation of chemokine production GO:0032642 18 13 0,000 0,03561558 0,06657144 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,03561558 0,06652055 ! peroxisomal transport GO:0043574 28 13 0,000 0,03561558 0,06646973 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,03561558 0,06641899 ! cartilage condensation GO:0001502 22 13 0,000 0,03561558 0,06636832 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,03561558 0,06631774 ! organelle fusion GO:0048284 36 13 0,000 0,03561558 0,06626723 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,03561558 0,0662168 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,03561558 0,06616644 ! endocrine pancreas development GO:0031018 25 13 0,000 0,03561558 0,06611617 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,03561558 0,06606596 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,03561558 0,06601584 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,03561558 0,06596579 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,03561558 0,06591581 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,03561558 0,06586592 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,03561558 0,06581609 ! methionine metabolic process GO:0006555 31 13 0,000 0,03561558 0,06576634 ! plasma membrane organization GO:0007009 27 13 0,000 0,03561558 0,06571667 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,03561558 0,06566707 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,03561558 0,06561755 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,03561558 0,0655681 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,03561558 0,06551873 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,03561558 0,06546943 ! cytokine metabolic process GO:0042107 24 13 0,000 0,03561558 0,06542021 ! exocrine system development GO:0035272 34 13 0,000 0,03561558 0,06537105 ! asymmetric protein localization GO:0008105 24 13 0,000 0,03561558 0,06532198 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,03561558 0,06527297 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,03561558 0,06522404 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,03561558 0,06517519 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,03561558 0,0651264 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,03561558 0,06507769 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,03561558 0,06502905 ! protein homotetramerization GO:0051289 24 13 0,000 0,03561558 0,06498049 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,03561558 0,064932 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,03561558 0,06488357 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,03561558 0,06483523 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,03561558 0,06478695 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,03561558 0,06473875 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,03561558 0,06469061 ! histone methylation GO:0016571 29 13 0,000 0,03561558 0,06464255 ! chromatin silencing GO:0006342 29 13 0,000 0,03561558 0,06459456 ! gland morphogenesis GO:0022612 31 13 0,000 0,03561558 0,06454664 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,03561558 0,06449879 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,03561558 0,06445102 ! regulation of epidermis development GO:0045682 19 13 0,000 0,03561558 0,06440331 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,03561558 0,06435568 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,03561558 0,06430811 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,03561558 0,06426062 ! spleen development GO:0048536 24 13 0,000 0,03561558 0,06421319 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,03561558 0,06416584 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,03561558 0,06411855 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,03561558 0,06407134 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,03561558 0,06402419 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,03561558 0,06397711 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,03561558 0,06393011 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,03561558 0,06388317 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,03561558 0,0638363 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,03561558 0,0637895 ! insulin secretion GO:0030073 24 13 0,000 0,03561558 0,06374276 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,03561558 0,0636961 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,03561558 0,06364951 ! acrosome reaction GO:0007340 19 13 0,000 0,03561558 0,06360298 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,03561558 0,06355652 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,03561558 0,06351013 ! rRNA transcription GO:0009303 28 14 0,000 0,03830265 0,06825191 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,03830265 0,06820216 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,03830265 0,06815249 ! water transport GO:0006833 21 14 0,000 0,03830265 0,06810289 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,03830265 0,06805336 ! non-recombinational repair GO:0000726 29 14 0,000 0,03830265 0,0680039 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,03830265 0,06795452 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,03830265 0,0679052 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,03830265 0,06785596 ! RNA polyadenylation GO:0043631 32 14 0,000 0,03830265 0,06780679 ! lipid localization GO:0010876 32 14 0,000 0,03830265 0,06775769 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,03830265 0,06770866 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,03830265 0,0676597 ! regulated secretory pathway GO:0045055 24 14 0,000 0,03830265 0,06761082 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,03830265 0,067562 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,03830265 0,06751325 ! arginine metabolic process GO:0006525 21 14 0,000 0,03830265 0,06746458 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,03830265 0,06741597 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,03830265 0,06736744 ! regulation of heart rate GO:0002027 25 14 0,000 0,03830265 0,06731897 ! fear response GO:0042596 34 14 0,000 0,03830265 0,06727058 ! organic alcohol transport GO:0015850 29 14 0,000 0,03830265 0,06722225 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,03830265 0,06717399 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,03830265 0,0671258 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,03830265 0,06707768 ! neutral amino acid transport GO:0015804 28 14 0,000 0,03830265 0,06702963 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,03830265 0,06698165 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,03830265 0,06693374 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,03830265 0,0668859 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,03830265 0,06683812 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,03830265 0,06679041 ! regulation of cellular pH GO:0030641 27 14 0,000 0,03830265 0,06674277 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,03830265 0,0666952 ! ribosome assembly GO:0042255 18 14 0,000 0,03830265 0,0666477 ! cerebellum development GO:0021549 23 14 0,000 0,03830265 0,06660026 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,03830265 0,06655289 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,03830265 0,06650559 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,03830265 0,06645836 ! response to gamma radiation GO:0010332 30 14 0,000 0,03830265 0,06641119 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,03830265 0,06636409 ! NADP metabolic process GO:0006739 24 14 0,000 0,03830265 0,06631706 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,03830265 0,06627009 ! oxygen transport GO:0015671 22 14 0,000 0,03830265 0,06622319 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,03830265 0,06617636 ! male genitalia development GO:0030539 26 14 0,000 0,03830265 0,06612959 ! regulation of RNA stability GO:0043487 33 14 0,000 0,03830265 0,06608289 ! regulation of axon extension GO:0030516 43 14 0,000 0,03830265 0,06603625 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,03830265 0,06598968 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,03830265 0,06594318 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,03830265 0,06589674 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,0409823 0,07045726 ! lactation GO:0007595 30 15 0,000 0,0409823 0,07040771 ! reproductive cellular process GO:0048610 22 15 0,000 0,0409823 0,07035823 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,0409823 0,07030882 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,0409823 0,07025948 ! superoxide anion generation GO:0042554 22 15 0,000 0,0409823 0,07021021 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,0409823 0,07016101 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,0409823 0,07011188 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,0409823 0,07006281 ! copper ion transport GO:0006825 22 15 0,000 0,0409823 0,07001382 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,0409823 0,06996489 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,0409823 0,06991603 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,0409823 0,06986724 ! sulfate transport GO:0008272 27 15 0,000 0,0409823 0,06981852 ! response to cAMP GO:0051591 25 15 0,000 0,0409823 0,06976987 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,0409823 0,06972128 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,0409823 0,06967276 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,0409823 0,06962431 ! response to hexose stimulus GO:0009746 25 15 0,000 0,0409823 0,06957593 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,0409823 0,06952761 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,0409823 0,06947936 ! vesicle coating GO:0006901 38 15 0,000 0,0409823 0,06943118 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,0409823 0,06938306 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,0409823 0,06933501 ! regulation of exocytosis GO:0017157 26 15 0,000 0,0409823 0,06928703 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,0409823 0,06923911 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,0409823 0,06919126 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,0409823 0,06914348 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,0409823 0,06909576 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,0409823 0,06904811 ! regulation of vasodilation GO:0042312 27 15 0,000 0,0409823 0,06900052 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,0409823 0,068953 ! histone deacetylation GO:0016575 24 15 0,000 0,0409823 0,06890555 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,0409823 0,06885816 ! water homeostasis GO:0030104 28 15 0,000 0,0409823 0,06881083 ! cofactor transport GO:0051181 30 15 0,000 0,0409823 0,06876357 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,0409823 0,06871638 ! muscle maintenance GO:0046716 26 15 0,000 0,0409823 0,06866925 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,0409823 0,06862218 ! intestinal absorption GO:0050892 31 15 0,000 0,0409823 0,06857518 ! dopamine metabolic process GO:0042417 35 15 0,000 0,0409823 0,06852824 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,0409823 0,06848137 ! heme biosynthetic process GO:0006783 33 15 0,000 0,0409823 0,06843456 ! cell killing GO:0001906 32 15 0,000 0,0409823 0,06838781 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,0409823 0,06834113 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,0409823 0,06829452 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,0409823 0,06824796 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,0409823 0,06820147 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,0409823 0,06815504 ! actin filament polymerization GO:0030041 27 15 0,000 0,0409823 0,06810868 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,0409823 0,06806238 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,04365456 0,07245115 ! positive regulation of cell size GO:0045793 29 16 0,000 0,04365456 0,07240196 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,04365456 0,07235284 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,04365456 0,07230379 ! bone remodeling GO:0046849 28 16 0,000 0,04365456 0,07225481 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,04365456 0,07220589 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,04365456 0,07215703 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04365456 0,07210824 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,04365456 0,07205952 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,04365456 0,07201087 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,04365456 0,07196228 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,04365456 0,07191375 ! startle response GO:0001964 28 16 0,000 0,04365456 0,07186529 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,04365456 0,0718169 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,04365456 0,07176857 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,04365456 0,0717203 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,04365456 0,07167211 ! protein polyubiquitination GO:0000209 41 16 0,000 0,04365456 0,07162397 ! glutamate metabolic process GO:0006536 25 16 0,000 0,04365456 0,0715759 ! pituitary gland development GO:0021983 30 16 0,000 0,04365456 0,0715279 ! response to osmotic stress GO:0006970 27 16 0,000 0,04365456 0,07147996 ! lysosomal transport GO:0007041 31 16 0,000 0,04365456 0,07143208 ! fructose metabolic process GO:0006000 25 16 0,000 0,04365456 0,07138427 ! L-amino acid transport GO:0015807 33 16 0,000 0,04365456 0,07133652 ! stem cell development GO:0048864 46 16 0,000 0,04365456 0,07128883 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,04365456 0,07124121 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,04365456 0,07119365 ! intermediate filament-based process GO:0045103 36 16 0,000 0,04365456 0,07114616 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,04365456 0,07109873 ! negative regulation of immune response GO:0050777 38 16 0,000 0,04365456 0,07105136 ! axon cargo transport GO:0008088 46 16 0,000 0,04365456 0,07100406 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,04365456 0,07095682 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,04365456 0,07090964 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,04365456 0,07086252 ! DNA replication initiation GO:0006270 28 16 0,000 0,04365456 0,07081547 ! neuron recognition GO:0008038 40 16 0,000 0,04365456 0,07076848 ! mRNA splice site selection GO:0006376 44 16 0,000 0,04365456 0,07072155 ! tissue regeneration GO:0042246 27 16 0,000 0,04365456 0,07067468 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,04365456 0,07062788 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,04365456 0,07058113 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,04365456 0,07053445 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,04365456 0,07048783 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,04365456 0,07044128 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,04365456 0,07039478 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,04365456 0,07034835 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,04365456 0,07030197 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,04365456 0,07025566 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,04365456 0,07020941 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,04365456 0,07016322 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,04365456 0,07011709 ! peptide hormone processing GO:0016486 27 16 0,000 0,04365456 0,07007102 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,04631945 0,07429968 ! metencephalon development GO:0022037 32 17 0,000 0,04631945 0,07425093 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,04631945 0,07420224 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,04631945 0,07415362 ! signal complex assembly GO:0007172 47 17 0,000 0,04631945 0,07410505 ! endothelial cell migration GO:0043542 31 17 0,000 0,04631945 0,07405656 ! gene silencing by RNA GO:0031047 38 17 0,000 0,04631945 0,07400812 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,04631945 0,07395975 ! glial cell development GO:0021782 28 17 0,000 0,04631945 0,07391144 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,04631945 0,0738632 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,04631945 0,07381502 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,04631945 0,0737669 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,04631945 0,07371884 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,04631945 0,07367085 ! myoblast differentiation GO:0045445 50 17 0,000 0,04631945 0,07362291 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,04631945 0,07357504 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,04631945 0,07352724 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,04631945 0,07347949 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,04631945 0,07343181 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,04631945 0,07338419 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,04631945 0,07333663 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,04631945 0,07328913 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,04631945 0,07324169 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,04631945 0,07319432 ! membrane budding GO:0006900 42 17 0,000 0,04631945 0,07314701 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,04631945 0,07309975 ! regulation of protein binding GO:0043393 33 17 0,000 0,04631945 0,07305256 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,04631945 0,07300543 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,04631945 0,07295836 ! genitalia development GO:0048806 32 17 0,000 0,04631945 0,07291135 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,04631945 0,0728644 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,04631945 0,07281752 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,04631945 0,07277069 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,04631945 0,07272392 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,04631945 0,07267721 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,04631945 0,07263056 ! steroid catabolic process GO:0006706 34 17 0,000 0,04631945 0,07258398 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,04631945 0,07253745 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,04631945 0,07249098 ! gas transport GO:0015669 26 17 0,000 0,04631945 0,07244457 ! organic cation transport GO:0015695 32 17 0,000 0,04631945 0,07239822 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,04631945 0,07235193 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,04631945 0,0723057 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,04631945 0,07225953 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,04897699 0,0763566 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,04897699 0,0763079 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,04897699 0,07625926 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,04897699 0,07621069 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,04897699 0,07616218 ! adult walking behavior GO:0007628 36 18 0,000 0,04897699 0,07611373 ! patterning of blood vessels GO:0001569 43 18 0,000 0,04897699 0,07606534 ! heart looping GO:0001947 34 18 0,000 0,04897699 0,07601702 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,04897699 0,07596875 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,04897699 0,07592055 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,04897699 0,07587241 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,04897699 0,07582433 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,04897699 0,0757763 ! glycine metabolic process GO:0006544 30 18 0,000 0,04897699 0,07572835 ! glutamine metabolic process GO:0006541 29 18 0,000 0,04897699 0,07568045 ! response to retinoic acid GO:0032526 31 18 0,000 0,04897699 0,07563261 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,04897699 0,07558483 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,04897699 0,07553711 ! DNA integration GO:0015074 32 18 0,000 0,04897699 0,07548945 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,04897699 0,07544186 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,04897699 0,07539432 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,04897699 0,07534684 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,04897699 0,07529942 ! neural crest cell migration GO:0001755 41 18 0,000 0,04897699 0,07525207 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,04897699 0,07520477 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,04897699 0,07515753 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,04897699 0,07511035 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,04897699 0,07506323 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,04897699 0,07501617 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,04897699 0,07496916 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,04897699 0,07492222 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,04897699 0,07487534 ! detection of bacterium GO:0016045 22 18 0,000 0,04897699 0,07482851 ! nerve development GO:0021675 34 18 0,000 0,04897699 0,07478174 ! defense response to virus GO:0051607 43 18 0,000 0,04897699 0,07473503 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,04897699 0,07468838 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,04897699 0,07464179 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,0516272 0,0786317 ! positive regulation of translation GO:0045727 31 19 0,000 0,0516272 0,07858271 ! negative regulation of defense response GO:0031348 27 19 0,000 0,0516272 0,07853378 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,0516272 0,07848491 ! neuron maturation GO:0042551 46 19 0,000 0,0516272 0,0784361 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,0516272 0,07838735 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,0516272 0,07833866 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,0516272 0,07829003 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,0516272 0,07824147 ! inositol metabolic process GO:0006020 33 19 0,000 0,0516272 0,07819296 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,0516272 0,07814451 ! memory GO:0007613 34 19 0,000 0,0516272 0,07809613 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,0516272 0,0780478 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,0516272 0,07799953 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,0516272 0,07795132 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,0516272 0,07790318 ! cerebral cortex development GO:0021987 40 19 0,000 0,0516272 0,07785509 ! pigmentation during development GO:0048066 42 19 0,000 0,0516272 0,07780706 ! response to vitamin A GO:0033189 32 19 0,000 0,0516272 0,07775909 ! heme metabolic process GO:0042168 40 19 0,000 0,0516272 0,07771118 ! neuromuscular junction development GO:0007528 43 19 0,000 0,0516272 0,07766333 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,0516272 0,07761553 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,0516272 0,0775678 ! response to fungus GO:0009620 26 19 0,000 0,0516272 0,07752012 ! peptide cross-linking GO:0018149 39 19 0,000 0,0516272 0,07747251 ! protein export from nucleus GO:0006611 40 19 0,000 0,0516272 0,07742495 ! heart process GO:0003015 32 19 0,000 0,0516272 0,07737745 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,0516272 0,07733001 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,0516272 0,07728262 ! visual learning GO:0008542 38 19 0,000 0,0516272 0,0772353 ! cellular pigmentation GO:0033059 37 19 0,000 0,0516272 0,07718803 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,0516272 0,07714082 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,0516272 0,07709367 ! vitamin transport GO:0051180 31 19 0,000 0,0516272 0,07704657 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,0516272 0,07699954 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,0516272 0,07695256 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,0516272 0,07690564 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,0516272 0,07685877 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,0516272 0,07681196 ! cilium assembly GO:0042384 38 19 0,000 0,0516272 0,07676521 ! peptide hormone secretion GO:0030072 32 19 0,000 0,0516272 0,07671852 ! protein secretion GO:0009306 45 20 0,000 0,05427009 0,08059686 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,05427009 0,0805479 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,05427009 0,08049899 ! positive regulation of ossification GO:0045778 50 20 0,000 0,05427009 0,08045015 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,05427009 0,08040136 ! skin development GO:0043588 42 20 0,000 0,05427009 0,08035263 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,05427009 0,08030396 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,05427009 0,08025535 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,05427009 0,0802068 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,05427009 0,08015831 ! response to vitamin GO:0033273 36 20 0,000 0,05427009 0,08010987 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,05427009 0,0800615 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,05427009 0,08001318 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,05427009 0,07996492 ! bile acid metabolic process GO:0008206 34 20 0,000 0,05427009 0,07991672 ! response to alkaloid GO:0043279 38 20 0,000 0,05427009 0,07986858 ! retinoid metabolic process GO:0001523 34 20 0,000 0,05427009 0,07982049 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,05427009 0,07977247 ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,05427009 0,0797245 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,05427009 0,07967659 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,05427009 0,07962873 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,05427009 0,07958094 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,05427009 0,0795332 ! actin filament bundle formation GO:0051017 47 20 0,000 0,05427009 0,07948552 ! body fluid secretion GO:0007589 33 20 0,000 0,05427009 0,07943789 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,05427009 0,07939032 ! peptide secretion GO:0002790 38 20 0,000 0,05427009 0,07934281 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,05427009 0,07929536 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,05427009 0,07924796 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,05427009 0,07920062 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,05427009 0,07915334 ! cell-cell junction organization GO:0045216 43 20 0,000 0,05427009 0,07910611 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,05427009 0,07905894 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,05427009 0,07901182 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,05427009 0,07896476 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,05427009 0,07891776 ! regulation of glucose import GO:0046324 30 20 0,000 0,05427009 0,07887081 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,05427009 0,07882392 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,05427009 0,07877709 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,05427009 0,07873031 ! negative regulation of translation GO:0017148 32 20 0,000 0,05427009 0,07868358 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,05427009 0,07863692 ! regulation of cell killing GO:0031341 46 21 0,000 0,0569057 0,08240701 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,0569057 0,08235819 ! hormone secretion GO:0046879 39 21 0,000 0,0569057 0,08230943 ! cAMP metabolic process GO:0046058 41 21 0,000 0,0569057 0,08226072 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,0569057 0,08221208 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,0569057 0,08216349 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,0569057 0,08211496 ! smooth muscle contraction GO:0006939 48 21 0,000 0,0569057 0,08206648 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,0569057 0,08201807 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,0569057 0,08196971 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,0569057 0,08192141 ! plasma membrane fusion GO:0045026 33 21 0,000 0,0569057 0,08187316 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,0569057 0,08182497 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,0569057 0,08177684 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,0569057 0,08172876 ! sensory perception of pain GO:0019233 33 21 0,000 0,0569057 0,08168074 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,0569057 0,08163278 ! diencephalon development GO:0021536 36 21 0,000 0,0569057 0,08158487 ! collagen fibril organization GO:0030199 62 21 0,000 0,0569057 0,08153702 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,0569057 0,08148923 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,0569057 0,08144149 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,0569057 0,08139381 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,0569057 0,08134618 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,0569057 0,08129861 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,0569057 0,0812511 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,0569057 0,08120364 ! sperm-egg recognition GO:0035036 23 21 0,000 0,0569057 0,08115623 ! actin filament-based movement GO:0030048 47 21 0,000 0,0569057 0,08110888 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,0569057 0,08106159 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,05953403 0,0847562 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,05953403 0,08470684 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,05953403 0,08465754 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,05953403 0,08460829 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,05953403 0,0845591 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,05953403 0,08450996 ! microtubule-based transport GO:0010970 59 22 0,000 0,05953403 0,08446089 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,05953403 0,08441187 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,05953403 0,0843629 ! cellular response to starvation GO:0009267 37 22 0,000 0,05953403 0,084314 ! vacuolar transport GO:0007034 41 22 0,000 0,05953403 0,08426515 ! central nervous system neuron development GO:0021954 47 22 0,000 0,05953403 0,08421636 ! fucose metabolic process GO:0006004 44 22 0,000 0,05953403 0,08416762 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,05953403 0,08411894 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,05953403 0,08407032 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,05953403 0,08402175 ! ureteric bud development GO:0001657 50 22 0,000 0,05953403 0,08397324 ! cell aging GO:0007569 48 22 0,000 0,05953403 0,08392478 ! stem cell differentiation GO:0048863 57 22 0,000 0,05953403 0,08387638 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,05953403 0,08382804 ! cytolysis GO:0019835 27 22 0,000 0,05953403 0,08377975 ! renal system process GO:0003014 42 22 0,000 0,05953403 0,08373152 ! vasodilation GO:0042311 40 22 0,000 0,05953403 0,08368334 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,05953403 0,08363522 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,05953403 0,08358715 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,05953403 0,08353914 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,05953403 0,08349119 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,05953403 0,08344329 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,05953403 0,08339544 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,05953403 0,08334765 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,05953403 0,08329991 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,05953403 0,08325223 ! sarcomere organization GO:0045214 32 22 0,000 0,05953403 0,0832046 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,05953403 0,08315703 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,05953403 0,08310951 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,05953403 0,08306205 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,05953403 0,08301464 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,05953403 0,08296728 ! gut development GO:0048565 44 22 0,000 0,05953403 0,08291998 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,05953403 0,08287273 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,05953403 0,08282554 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,05953403 0,0827784 ! protein stabilization GO:0050821 41 22 0,000 0,05953403 0,08273131 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,06215512 0,08632459 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,06215512 0,08627554 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,06215512 0,08622655 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,06215512 0,08617761 ! gluconeogenesis GO:0006094 38 23 0,000 0,06215512 0,08612873 ! glycerol metabolic process GO:0006071 40 23 0,000 0,06215512 0,08607991 ! viral genome replication GO:0019079 44 23 0,000 0,06215512 0,08603114 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,06215512 0,08598242 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,06215512 0,08593376 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,06215512 0,08588515 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,06215512 0,0858366 ! regeneration GO:0031099 42 23 0,000 0,06215512 0,08578811 ! axis specification GO:0009798 43 23 0,000 0,06215512 0,08573967 ! visual behavior GO:0007632 46 23 0,000 0,06215512 0,08569128 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,06215512 0,08564295 ! response to ethanol GO:0045471 47 23 0,000 0,06215512 0,08559468 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,06215512 0,08554645 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,06215512 0,08549828 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,06215512 0,08545017 ! peroxisome organization GO:0007031 43 23 0,000 0,06215512 0,08540211 ! lysosome organization GO:0007040 47 23 0,000 0,06215512 0,08535411 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,06215512 0,08530615 ! vesicle targeting GO:0006903 49 23 0,000 0,06215512 0,08525826 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,06215512 0,08521041 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,06215512 0,08516262 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,06215512 0,08511488 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,06215512 0,0850672 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,06215512 0,08501957 ! DNA modification GO:0006304 36 23 0,000 0,06215512 0,08497199 ! fatty acid transport GO:0015908 47 23 0,000 0,06215512 0,08492447 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,06215512 0,084877 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,06215512 0,08482958 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,06215512 0,08478222 ! hormone transport GO:0009914 41 23 0,000 0,06215512 0,08473491 ! cell-cell recognition GO:0009988 28 23 0,000 0,06215512 0,08468765 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,06215512 0,08464044 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,06215512 0,08459329 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,06215512 0,08454619 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,06476897 0,08805264 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,06476897 0,08800367 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,06476897 0,08795475 ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,06476897 0,08790589 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,06476897 0,08785708 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,06476897 0,08780832 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,06476897 0,08775962 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,06476897 0,08771097 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,06476897 0,08766238 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,06476897 0,08761384 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,06476897 0,08756535 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,06476897 0,08751692 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,06476897 0,08746854 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,06476897 0,08742022 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,06476897 0,08737195 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,06476897 0,08732373 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,06476897 0,08727556 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,06476897 0,08722745 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,06476897 0,08717939 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 52 24 0,000 0,06476897 0,08713138 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,06476897 0,08708343 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,06476897 0,08703553 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,06476897 0,08698768 ! membrane depolarization GO:0051899 45 24 0,000 0,06476897 0,08693989 ! oogenesis GO:0048477 44 24 0,000 0,06476897 0,08689214 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,06476897 0,08684445 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,06476897 0,08679682 ! platelet activation GO:0030168 41 24 0,000 0,06476897 0,08674923 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,06476897 0,0867017 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,06476897 0,08665421 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,06476897 0,08660678 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,06476897 0,08655941 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,06476897 0,08651208 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,06476897 0,08646481 ! regulation of amine transport GO:0051952 41 24 0,000 0,06476897 0,08641758 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,06476897 0,08637041 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,06737561 0,08979739 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,06737561 0,08974843 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,06737561 0,08969952 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,06737561 0,08965066 ! leukocyte adhesion GO:0007159 55 25 0,000 0,06737561 0,08960186 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,06737561 0,08955311 ! phototransduction GO:0007602 37 25 0,000 0,06737561 0,08950441 ! keratinization GO:0031424 37 25 0,000 0,06737561 0,08945577 ! vasculogenesis GO:0001570 49 25 0,000 0,06737561 0,08940718 ! vacuole organization GO:0007033 49 25 0,000 0,06737561 0,08935864 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,06737561 0,08931016 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,06737561 0,08926172 ! receptor metabolic process GO:0043112 53 25 0,000 0,06737561 0,08921334 ! chromosome condensation GO:0030261 48 25 0,000 0,06737561 0,08916501 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,06737561 0,08911674 ! regulation of behavior GO:0050795 48 25 0,000 0,06737561 0,08906852 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,06737561 0,08902034 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,06737561 0,08897223 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,06737561 0,08892416 ! immunoglobulin production GO:0002377 62 25 0,000 0,06737561 0,08887614 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,06737561 0,08882818 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,06737561 0,08878027 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,06737561 0,08873241 ! liver development GO:0001889 55 25 0,000 0,06737561 0,0886846 ! protein tetramerization GO:0051262 57 25 0,000 0,06737561 0,08863684 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,06997506 0,09200703 ! myelination GO:0042552 50 26 0,000 0,06997506 0,09195754 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,06997506 0,0919081 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,06997506 0,09185872 ! molting cycle process GO:0022404 52 26 0,000 0,06997506 0,09180938 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,06997506 0,0917601 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,06997506 0,09171087 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,06997506 0,0916617 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,06997506 0,09161258 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,06997506 0,09156351 ! digestive system process GO:0022600 49 26 0,000 0,06997506 0,09151449 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,06997506 0,09146553 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 0,000 0,06997506 0,09141662 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 0,000 0,06997506 0,09136776 GO:0045936|negative regulation of phosphate metabolic process, ! osteoblast differentiation GO:0001649 63 26 0,000 0,06997506 0,09131895 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,06997506 0,09127019 ! neural crest cell development GO:0014032 59 26 0,000 0,06997506 0,09122149 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,06997506 0,09117284 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,06997506 0,09112424 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,06997506 0,09107569 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,06997506 0,09102719 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,06997506 0,09097875 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,06997506 0,09093036 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,06997506 0,09088201 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,06997506 0,09083372 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,06997506 0,09078549 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,06997506 0,0907373 ! blastocyst development GO:0001824 50 26 0,000 0,06997506 0,09068916 ! telomere organization GO:0032200 46 26 0,000 0,06997506 0,09064108 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,06997506 0,09059304 ! alditol metabolic process GO:0019400 44 26 0,000 0,06997506 0,09054506 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,06997506 0,09049713 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,06997506 0,09044924 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,07256734 0,0937504 ! embryonic pattern specification GO:0009880 49 27 0,000 0,07256734 0,09370085 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,07256734 0,09365135 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,07256734 0,0936019 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,07256734 0,09355251 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,07256734 0,09350317 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,07256734 0,09345388 ! superoxide metabolic process GO:0006801 41 27 0,000 0,07256734 0,09340464 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,07256734 0,09335545 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,07256734 0,09330632 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,07256734 0,09325723 ! response to starvation GO:0042594 47 27 0,000 0,07256734 0,0932082 ! response to toxin GO:0009636 49 27 0,000 0,07256734 0,09315922 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,07256734 0,09311029 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,07256734 0,09306142 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,07256734 0,09301259 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,07256734 0,09296382 ! leukocyte proliferation GO:0070661 59 27 0,000 0,07256734 0,09291509 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,07256734 0,09286642 ! regulation of fibroblast proliferation GO:0048145 56 28 0,000 0,07515246 0,09612432 ! neuron fate commitment GO:0048663 52 28 0,000 0,07515246 0,09607402 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,07515246 0,09602378 ! vesicle docking GO:0048278 55 28 0,000 0,07515246 0,09597358 ! circadian rhythm GO:0007623 56 28 0,000 0,07515246 0,09592344 ! dendrite development GO:0016358 67 28 0,000 0,07515246 0,09587335 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,07515246 0,09582331 ! fat cell differentiation GO:0045444 57 28 0,000 0,07515246 0,09577332 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,07515246 0,09572339 ! sperm motility GO:0030317 37 28 0,000 0,07515246 0,09567351 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,07515246 0,09562368 ! base-excision repair GO:0006284 41 28 0,000 0,07515246 0,0955739 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,07515246 0,09552417 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,07515246 0,0954745 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,07515246 0,09542487 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,07515246 0,0953753 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,07515246 0,09532578 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,07515246 0,09527631 ! peptidyl-tyrosine modification GO:0018212 57 28 0,000 0,07515246 0,0952269 ! glutathione metabolic process GO:0006749 42 28 0,000 0,07515246 0,09517753 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,07515246 0,09512822 ! lipid oxidation GO:0034440 48 28 0,000 0,07515246 0,09507895 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,07515246 0,09502974 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,07515246 0,09498058 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,07773045 0,09818795 ! translational initiation GO:0006413 66 29 0,000 0,07773045 0,0981372 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,07773045 0,09808651 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,07773045 0,09803587 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,07773045 0,09798529 ! autophagy GO:0006914 47 29 0,000 0,07773045 0,09793475 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,07773045 0,09788427 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,07773045 0,09783384 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,07773045 0,09778346 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,07773045 0,09773314 ! synaptogenesis GO:0007416 46 29 0,000 0,07773045 0,09768286 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,07773045 0,09763264 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,07773045 0,09758247 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,07773045 0,09753235 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,08030133 0,10070644 ! phenol metabolic process GO:0018958 56 30 0,000 0,08030133 0,10065477 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,08030133 0,10060315 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,08030133 0,10055158 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,08030133 0,10050007 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,08030133 0,10044861 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,08030133 0,10039721 ! acute-phase response GO:0006953 50 30 0,000 0,08030133 0,10034585 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,08030133 0,10029455 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,08030133 0,1002433 ! myofibril assembly GO:0030239 50 30 0,000 0,08030133 0,1001921 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,08030133 0,10014096 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,08030133 0,10008987 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,08030133 0,10003883 ! cell fate determination GO:0001709 64 30 0,000 0,08030133 0,09998784 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,08030133 0,0999369 ! phospholipid transport GO:0015914 65 30 0,000 0,08030133 0,09988602 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,08030133 0,09983519 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,08030133 0,0997844 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,08030133 0,09973368 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,08030133 0,099683 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,08030133 0,09963237 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,08030133 0,0995818 ! regulation of coagulation GO:0050818 52 30 0,000 0,08030133 0,09953127 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,08286511 0,10265693 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,08286511 0,1026049 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,08286511 0,10255292 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,08286511 0,10250099 ! cell junction assembly GO:0034329 85 31 0,000 0,08286511 0,10244912 ! regulation of innate immune response GO:0045088 57 31 0,000 0,08286511 0,1023973 ! peptide transport GO:0015833 60 31 0,000 0,08286511 0,10234553 ! male gonad development GO:0008584 56 31 0,000 0,08286511 0,10229382 ! detection of light stimulus GO:0009583 44 31 0,000 0,08286511 0,10224215 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,08286511 0,10219054 ! natural killer cell activation GO:0030101 50 31 0,000 0,08286511 0,10213898 ! ensheathment of neurons GO:0007272 64 31 0,000 0,08286511 0,10208747 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,08286511 0,10203602 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,08286511 0,10198461 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,08286511 0,10193326 ! eye morphogenesis GO:0048592 65 31 0,000 0,08286511 0,10188196 ! response to heat GO:0009408 54 31 0,000 0,08286511 0,10183071 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,08286511 0,10177952 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,08542182 0,10486708 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,08542182 0,10481441 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,08542182 0,1047618 ! spindle organization GO:0007051 50 32 0,000 0,08542182 0,10470923 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,08542182 0,10465672 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,08542182 0,10460426 ! metanephros development GO:0001656 81 32 0,000 0,08542182 0,10455185 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,08542182 0,1044995 ! muscle cell development GO:0055001 52 32 0,000 0,08542182 0,1044472 ! mesoderm formation GO:0001707 73 32 0,000 0,08542182 0,10439495 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,08542182 0,10434275 ! peripheral nervous system development GO:0007422 68 32 0,000 0,08542182 0,1042906 ! BMP signaling pathway GO:0030509 71 32 0,000 0,08542182 0,10423851 ! hindbrain development GO:0030902 65 32 0,000 0,08542182 0,10418647 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,08542182 0,10413448 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,08542182 0,10408254 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,08542182 0,10403066 ! gene silencing GO:0016458 71 32 0,000 0,08542182 0,10397882 ! regulation of pH GO:0006885 56 33 0,000 0,08797147 0,10702903 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,08797147 0,10697576 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,08797147 0,10692254 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,08797147 0,10686937 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,08797147 0,10681625 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,08797147 0,10676319 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,08797147 0,10671018 ! response to ionizing radiation GO:0010212 74 33 0,000 0,08797147 0,10665722 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,08797147 0,10660431 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,08797147 0,10655146 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,08797147 0,10649866 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,08797147 0,10644591 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,08797147 0,10639322 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,08797147 0,10634057 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,09051408 0,10935999 ! glial cell differentiation GO:0010001 67 34 0,000 0,09051408 0,10930594 ! post-embryonic development GO:0009791 76 34 0,000 0,09051408 0,10925193 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,09051408 0,10919798 ! cholesterol transport GO:0030301 62 34 0,000 0,09051408 0,10914408 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,09051408 0,10909024 ! spliceosome assembly GO:0000245 75 34 0,000 0,09051408 0,10903644 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,09051408 0,1089827 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,09051408 0,10892902 ! formation of primary germ layer GO:0001704 76 34 0,000 0,09051408 0,10887538 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,09051408 0,1088218 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,09051408 0,10876828 ! adult locomotory behavior GO:0008344 62 34 0,000 0,09051408 0,1087148 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,09304968 0,11170534 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,09304968 0,11165048 ! negative regulation of secretion GO:0051048 68 35 0,000 0,09304968 0,11159567 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,09304968 0,11154091 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,09304968 0,11148621 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,09304968 0,11143156 ! membrane docking GO:0022406 69 35 0,000 0,09304968 0,11137696 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,09304968 0,11132242 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,09304968 0,11126793 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,09304968 0,11121349 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,09304968 0,11115911 ! ceramide metabolic process GO:0006672 72 35 0,000 0,09304968 0,11110478 ! sterol transport GO:0015918 63 35 0,000 0,09304968 0,1110505 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,09304968 0,11099628 ! placenta development GO:0001890 53 35 0,000 0,09304968 0,11094211 ! vesicle localization GO:0051648 70 35 0,000 0,09304968 0,11088799 ! regulation of muscle development GO:0048634 82 36 0,000 0,09557828 0,1138458 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,09557828 0,11379032 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,09557828 0,1137349 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,09557828 0,11367953 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,09557828 0,11362421 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,09557828 0,11356894 ! positive regulation of cell development GO:0010720 85 36 0,000 0,09557828 0,11351373 ! protein targeting to membrane GO:0006612 75 36 0,000 0,09557828 0,11345857 ! regulation of proteolysis GO:0030162 77 36 0,000 0,09557828 0,11340347 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,09557828 0,11334842 ! aerobic respiration GO:0009060 56 36 0,000 0,09557828 0,11329342 ! cytokine production GO:0001816 68 36 0,000 0,09557828 0,11323848 ! embryonic organ development GO:0048568 67 36 0,000 0,09557828 0,11318359 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,09557828 0,11312875 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,09557828 0,11307397 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,09809991 0,116001 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,09809991 0,11594488 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,09809991 0,11588881 ! sister chromatid segregation GO:0000819 65 37 0,000 0,09809991 0,1158328 ! odontogenesis GO:0042476 74 37 0,000 0,09809991 0,11577684 ! actomyosin structure organization GO:0031032 68 37 0,000 0,09809991 0,11572094 ! cell junction organization GO:0034330 96 37 0,000 0,09809991 0,11566509 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,09809991 0,11560929 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,09809991 0,11555355 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,09809991 0,11549786 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,10061457 0,11840144 ! meiosis I GO:0007127 74 38 0,000 0,10061457 0,11834443 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,10061457 0,11828748 ! organic anion transport GO:0015711 82 38 0,000 0,10061457 0,11823059 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,10061457 0,11817374 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,10061457 0,11811696 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,10061457 0,11806022 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,10061457 0,11800355 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,10061457 0,11794692 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,10061457 0,11789035 ! regulation of protein stability GO:0031647 77 38 0,000 0,10061457 0,11783384 ! spermatid development GO:0007286 69 38 0,000 0,10061457 0,11777738 ! glycogen metabolic process GO:0005977 63 38 0,000 0,10061457 0,11772097 ! pigment metabolic process GO:0042440 87 38 0,000 0,10061457 0,11766462 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,10312229 0,12053959 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,10312229 0,12048195 ! negative regulation of binding GO:0051100 71 39 0,000 0,10312229 0,12042436 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,10312229 0,12036682 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,10312229 0,12030934 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,10312229 0,12025191 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,10312229 0,12019454 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,10312229 0,12013722 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,10312229 0,12007996 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,10312229 0,12002275 ! glucan metabolic process GO:0044042 64 39 0,000 0,10312229 0,1199656 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,10562309 0,12281638 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,10562309 0,12275795 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,10562309 0,12269957 ! learning GO:0007612 82 40 0,000 0,10562309 0,12264126 ! nucleus organization GO:0006997 73 40 0,000 0,10562309 0,122583 ! lipid homeostasis GO:0055088 75 40 0,000 0,10562309 0,12252479 ! mismatch repair GO:0006298 58 40 0,000 0,10562309 0,12246664 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,10562309 0,12240854 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,10562309 0,1223505 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,10562309 0,12229251 ! RNA export from nucleus GO:0006405 61 41 0,000 0,10811699 0,1251207 ! mRNA catabolic process GO:0006402 79 41 0,000 0,10811699 0,12506146 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,10811699 0,12500227 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,10811699 0,12494314 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,10811699 0,12488406 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,10811699 0,12482504 ! feeding behavior GO:0007631 69 41 0,000 0,10811699 0,12476608 ! mesenchymal cell development GO:0014031 94 41 0,000 0,10811699 0,12470717 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,10811699 0,12464832 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,10811699 0,12458953 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,10811699 0,12453078 ! spermatid differentiation GO:0048515 73 41 0,000 0,10811699 0,1244721 ! RNA modification GO:0009451 64 41 0,000 0,10811699 0,12441347 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,110604 0,12721543 ! ear morphogenesis GO:0042471 64 42 0,000 0,110604 0,12715556 ! organic ether metabolic process GO:0018904 59 42 0,000 0,110604 0,12709575 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,110604 0,127036 ! regulation of intracellular protein transport GO:0033157 86 42 0,000 0,110604 0,1269763 ! T cell differentiation GO:0030217 93 42 0,000 0,110604 0,12691666 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,110604 0,12685707 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,110604 0,12679754 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,110604 0,12673807 ! regulation of protein secretion GO:0050708 77 42 0,000 0,110604 0,12667865 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,110604 0,12661929 ! cytokinesis GO:0000910 84 42 0,000 0,110604 0,12655998 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,110604 0,12650073 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,11308415 0,12927682 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,11308415 0,12921636 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,11308415 0,12915595 ! regulation of tube size GO:0035150 76 43 0,000 0,11308415 0,12909559 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,11308415 0,1290353 ! glucose transport GO:0015758 66 43 0,000 0,11308415 0,12897506 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,11308415 0,12891487 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,11308415 0,12885474 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,11308415 0,12879467 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,11308415 0,12873465 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,11308415 0,12867469 ! ion transmembrane transport GO:0034220 79 43 0,000 0,11308415 0,12861479 ! neuron migration GO:0001764 85 43 0,000 0,11308415 0,12855494 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,11555745 0,13130551 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,11555745 0,13124446 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,11555745 0,13118348 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,11555745 0,13112255 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,11555745 0,13106167 ! hexose transport GO:0008645 68 44 0,000 0,11555745 0,13100086 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,11555745 0,13094009 ! striated muscle contraction GO:0006941 85 44 0,000 0,11555745 0,13087939 ! phagocytosis GO:0006909 105 44 0,000 0,11555745 0,13081874 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,11555745 0,13075815 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,11802392 0,13348724 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,11802392 0,13342547 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,11802392 0,13336375 ! biopolymer methylation GO:0043414 91 45 0,000 0,11802392 0,1333021 ! B cell differentiation GO:0030183 124 45 0,000 0,11802392 0,1332405 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,11802392 0,13317896 ! female gamete generation GO:0007292 71 45 0,000 0,11802392 0,13311747 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,11802392 0,13305604 ! polyol metabolic process GO:0019751 77 45 0,000 0,11802392 0,13299467 ! developmental growth GO:0048589 88 45 0,000 0,11802392 0,13293335 ! maintenance of location in cell GO:0051651 101 45 0,000 0,11802392 0,13287209 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,12048359 0,13557872 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,12048359 0,1355163 ! glycolysis GO:0006096 71 46 0,000 0,12048359 0,13545393 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 0,000 0,12048359 0,13539163 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,12048359 0,13532938 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,12048359 0,13526719 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,12048359 0,13520505 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,12048359 0,13514297 ! pigmentation GO:0043473 103 46 0,000 0,12048359 0,13508095 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,12048359 0,13501899 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,12293646 0,13770462 ! positive regulation of defense response GO:0031349 88 48 0,000 0,12538256 0,1403802 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,12538256 0,14031589 ! mitochondrial transport GO:0006839 94 48 0,000 0,12538256 0,14025165 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,12538256 0,14018746 ! cellular component disassembly GO:0022411 89 48 0,000 0,12538256 0,14012333 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,12538256 0,14005926 ! endosome transport GO:0016197 127 48 0,000 0,12538256 0,13999525 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,12538256 0,13993129 ! male sex differentiation GO:0046661 93 48 0,000 0,12538256 0,1398674 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,12538256 0,13980356 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,12538256 0,13973978 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,12538256 0,13967606 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,12538256 0,1396124 ! methylation GO:0032259 97 48 0,000 0,12538256 0,13954879 ! response to calcium ion GO:0051592 94 49 0,000 0,12782191 0,14219897 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,12782191 0,14213424 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,12782191 0,14206958 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,12782191 0,14200497 ! JNK cascade GO:0007254 106 49 0,000 0,12782191 0,14194042 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,12782191 0,14187593 ! protein homooligomerization GO:0051260 84 49 0,000 0,12782191 0,1418115 ! regulation of action potential GO:0001508 102 50 0,000 0,13025452 0,14444476 ! regulation of ion transport GO:0043269 86 50 0,000 0,13025452 0,14437922 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,13025452 0,14431374 ! endocrine system development GO:0035270 109 50 0,000 0,13025452 0,14424832 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,13025452 0,14418296 ! activation of caspase activity GO:0006919 95 50 0,000 0,13025452 0,14411766 ! regulation of ossification GO:0030278 123 50 0,000 0,13025452 0,14405242 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,13025452 0,14398724 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,13025452 0,14392212 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,13025452 0,14385705 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,13025452 0,14379205 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,13268042 0,14640392 ! peptide metabolic process GO:0006518 80 51 0,000 0,13268042 0,14633782 ! response to temperature stimulus GO:0009266 84 51 0,000 0,13268042 0,14627178 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,13268042 0,14620581 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,13268042 0,14613989 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,13509962 0,14873744 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,13509962 0,14867044 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,13509962 0,1486035 ! excretion GO:0007588 87 52 0,000 0,13509962 0,14853662 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,13509962 0,1484698 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,13509962 0,14840305 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,13509962 0,14833635 ! amino acid activation GO:0043038 98 52 0,000 0,13509962 0,14826971 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,13751214 0,15084964 ! positive regulation of growth GO:0045927 96 53 0,000 0,13751214 0,15078194 ! inner ear development GO:0048839 89 53 0,000 0,13751214 0,15071429 ! chromatin remodeling GO:0006338 122 53 0,000 0,13751214 0,15064671 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,13751214 0,15057918 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,13751214 0,15051172 ! vesicle organization GO:0016050 127 53 0,000 0,13751214 0,15044432 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,13751214 0,15037697 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,13751214 0,15030969 ! synapse organization GO:0050808 102 53 0,000 0,13751214 0,15024247 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,139918 0,15280271 ! regulation of translational initiation GO:0006446 87 54 0,000 0,139918 0,15273444 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,139918 0,15266622 ! neuromuscular process GO:0050905 107 54 0,000 0,139918 0,15259807 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,139918 0,15252997 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,139918 0,15246194 ! membrane fusion GO:0006944 122 54 0,000 0,139918 0,15239397 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,139918 0,15232606 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,139918 0,1522582 ! regulation of cell shape GO:0008360 142 54 0,000 0,139918 0,15219041 ! RNA catabolic process GO:0006401 103 55 0,000 0,14231721 0,15473117 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,14231721 0,15466234 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,14231721 0,15459357 ! cell recognition GO:0008037 98 55 0,000 0,14231721 0,15452487 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,14231721 0,15445622 ! cell maturation GO:0048469 107 55 0,000 0,14231721 0,15438763 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,14231721 0,15431911 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,14231721 0,15425064 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,1447098 0,1567743 ! glucose catabolic process GO:0006007 88 56 0,000 0,1447098 0,15670481 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,1447098 0,15663538 ! regulation of DNA replication GO:0006275 105 56 0,000 0,1447098 0,15656601 ! RNA elongation GO:0006354 90 56 0,000 0,1447098 0,1564967 ! chloride transport GO:0006821 102 57 0,000 0,14709578 0,15900664 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,14709578 0,15893631 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,14709578 0,15886605 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 0,000 0,14709578 0,15879585 ! heart morphogenesis GO:0003007 105 57 0,000 0,14709578 0,15872571 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,14709578 0,15865563 ! regulation of intracellular transport GO:0032386 108 57 0,000 0,14709578 0,15858561 ! regulation of actin filament length GO:0030832 118 58 0,000 0,14947518 0,16107978 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,14947518 0,16100876 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,14947518 0,16093779 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,14947518 0,1608669 ! aging GO:0007568 112 58 0,000 0,14947518 0,16079606 ! gastrulation GO:0007369 122 58 0,000 0,14947518 0,16072529 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,14947518 0,16065458 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,14947518 0,16058393 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,14947518 0,16051334 ! maintenance of location GO:0051235 124 58 0,000 0,14947518 0,16044282 ! nuclear export GO:0051168 110 59 0,000 0,151848 0,16291816 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,15421427 0,16538431 ! DNA catabolic process GO:0006308 94 60 0,000 0,15421427 0,16531174 ! regulation of endocytosis GO:0030100 104 60 0,000 0,15421427 0,16523923 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,15421427 0,16516679 ! adult behavior GO:0030534 104 60 0,000 0,15421427 0,16509441 ! kidney development GO:0001822 133 60 0,000 0,15421427 0,1650221 ! positive regulation of secretion GO:0051047 110 61 0,000 0,156574 0,16747385 ! regulation of cellular component size GO:0032535 125 61 0,000 0,156574 0,16740056 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,156574 0,16732733 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,156574 0,16725417 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,156574 0,16718107 ! camera-type eye development GO:0043010 126 61 0,000 0,156574 0,16710803 ! proton transport GO:0015992 117 61 0,000 0,156574 0,16703506 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,156574 0,16696215 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,15892722 0,16939755 ! tRNA processing GO:0008033 102 62 0,000 0,15892722 0,16932368 ! regulation of homeostatic process GO:0032844 148 62 0,000 0,15892722 0,16924987 ! regulation of mitosis GO:0007088 112 63 0,000 0,16127393 0,17167417 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,16127393 0,1715994 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,16127393 0,17152469 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,16127393 0,17145005 ! hydrogen transport GO:0006818 121 64 0,000 0,16361417 0,17386229 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,16361417 0,1737867 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,16361417 0,17371118 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,16594794 0,17611243 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,16594794 0,17603596 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,16594794 0,17595956 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,16594794 0,17588322 ! ear development GO:0043583 114 66 0,000 0,16827526 0,17827254 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,16827526 0,17819526 ! activation of MAPK activity GO:0000187 124 67 0,000 0,17059616 0,18057471 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,17059616 0,1804965 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,17059616 0,18041836 ! secondary metabolic process GO:0019748 125 67 0,000 0,17059616 0,18034029 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,17291065 0,18270792 ! hexose catabolic process GO:0019320 113 68 0,000 0,17291065 0,18262893 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,17291065 0,18255 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,17291065 0,18247115 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,17291065 0,18239236 ! adaptive immune response GO:0002250 126 68 0,000 0,17291065 0,18231364 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,17291065 0,18223499 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,17521874 0,18458791 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,17521874 0,18450835 ! urogenital system development GO:0001655 149 69 0,000 0,17521874 0,18442886 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,17521874 0,18434943 ! single fertilization GO:0007338 83 69 0,000 0,17521874 0,18427007 ! cell redox homeostasis GO:0045454 114 70 0,000 0,17752045 0,18661035 ! germ cell development GO:0007281 133 70 0,000 0,17752045 0,18653009 ! activation of immune response GO:0002253 120 70 0,000 0,17752045 0,1864499 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,17752045 0,18636977 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,17981581 0,18869846 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,17981581 0,18861744 ! carbohydrate transport GO:0008643 114 72 0,000 0,18210482 0,19093652 ! actin filament organization GO:0007015 167 72 0,000 0,18210482 0,19085461 ! B cell activation GO:0042113 179 72 0,000 0,18210482 0,19077276 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,18210482 0,19069099 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,18210482 0,19060929 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,18210482 0,19052766 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,18210482 0,1904461 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,18210482 0,19036461 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,18438751 0,19266839 ! regulation of immune effector process GO:0002697 156 73 0,000 0,18438751 0,19258602 ! acute inflammatory response GO:0002526 118 74 0,000 0,1866639 0,1948803 ! amino acid transport GO:0006865 148 74 0,000 0,1866639 0,19479706 ! regulation of caspase activity GO:0043281 136 74 0,000 0,1866639 0,19471388 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,1866639 0,19463078 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,18893399 0,19691372 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,18893399 0,19682974 ! eye development GO:0001654 155 75 0,000 0,18893399 0,19674584 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,19119782 0,19901844 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,19119782 0,19893367 ! learning or memory GO:0007611 161 76 0,000 0,19119782 0,19884899 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,19119782 0,19876437 ! regulation of blood pressure GO:0008217 134 76 0,000 0,19119782 0,19867982 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,19119782 0,19859535 ! amine catabolic process GO:0009310 136 77 0,000 0,19345539 0,20085487 ! neurotransmitter transport GO:0006836 142 77 0,000 0,19345539 0,20076954 ! regulation of endopeptidase activity GO:0052548 141 77 0,000 0,19345539 0,20068429 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,19345539 0,20059911 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,19345539 0,200514 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,19345539 0,20042897 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,19345539 0,200344 ! regulation of catabolic process GO:0009894 173 77 0,000 0,19345539 0,20025911 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,19570672 0,20250381 ! antigen processing and presentation GO:0019882 117 78 0,000 0,19570672 0,20241808 ! fertilization GO:0009566 99 78 0,000 0,19570672 0,20233242 ! positive regulation of lymphocyte activation GO:0051251 142 78 0,000 0,19570672 0,20224683 ! blood coagulation GO:0007596 151 79 0,000 0,19795182 0,20448047 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,19795182 0,20439404 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,19795182 0,20430769 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,19795182 0,20422141 ! protein oligomerization GO:0051259 149 79 0,000 0,19795182 0,20413521 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,19795182 0,20404907 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,20019073 0,20626991 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,20019073 0,20618295 ! meiosis GO:0007126 143 81 0,000 0,20242345 0,20839464 GO:0051327|M phase of meiotic cell cycle, ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,20242345 0,20830686 ! regulation of peptidase activity GO:0052547 150 82 0,000 0,20465 0,21050945 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,20465 0,21042085 ! protein import into nucleus GO:0006606 174 82 0,000 0,20465 0,21033233 ! meiotic cell cycle GO:0051321 144 82 0,000 0,20465 0,21024388 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,20687039 0,21243563 ! exocytosis GO:0006887 153 83 0,000 0,20687039 0,21234637 ! response to drug GO:0042493 149 83 0,000 0,20687039 0,21225719 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,20687039 0,21216808 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,20687039 0,21207905 ! nuclear import GO:0051170 177 83 0,000 0,20687039 0,21199009 ! inorganic anion transport GO:0015698 156 83 0,000 0,20687039 0,2119012 ! response to metal ion GO:0010038 158 84 0,000 0,20908465 0,21407955 ! T cell activation GO:0042110 189 84 0,000 0,20908465 0,21398986 ! response to nutrient GO:0007584 135 84 0,000 0,20908465 0,21390025 ! digestion GO:0007586 130 84 0,000 0,20908465 0,21381072 ! regulation of ligase activity GO:0051340 147 84 0,000 0,20908465 0,21372125 ! hemostasis GO:0007599 165 85 0,000 0,21129279 0,21588803 ! negative regulation of transport GO:0051051 164 85 0,000 0,21129279 0,21579778 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,21129279 0,2157076 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,21129279 0,2156175 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,21129279 0,21552747 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,21349483 0,21768275 ! regulation of lyase activity GO:0051339 169 86 0,000 0,21349483 0,21759193 ! positive regulation of cell activation GO:0050867 161 86 0,000 0,21349483 0,21750119 GO:0002696|positive regulation of leukocyte activation, ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,21569078 0,21964676 ! mitochondrion organization GO:0007005 159 87 0,000 0,21569078 0,21955524 ! alcohol catabolic process GO:0046164 142 87 0,000 0,21569078 0,21946379 ! nucleosome assembly GO:0006334 126 87 0,000 0,21569078 0,21937243 ! regulation of protein transport GO:0051223 165 87 0,000 0,21569078 0,21928113 GO:0070201|regulation of establishment of protein localization, ! cellular respiration GO:0045333 143 88 0,000 0,21788066 0,22141533 ! amine biosynthetic process GO:0009309 146 88 0,000 0,21788066 0,22132326 ! sensory perception of smell GO:0007608 117 88 0,000 0,21788066 0,22123127 ! chromatin assembly GO:0031497 128 88 0,000 0,21788066 0,22113936 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,21788066 0,22104753 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,22006449 0,22317042 ! cellular defense response GO:0006968 123 89 0,000 0,22006449 0,22307782 ! protein localization in nucleus GO:0034504 192 89 0,000 0,22006449 0,22298529 ! regulation of neurological system process GO:0031644 175 89 0,000 0,22006449 0,22289284 ! response to inorganic substance GO:0010035 173 90 0,000 0,22224228 0,22500534 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,22224228 0,22491213 ! response to unfolded protein GO:0006986 139 90 0,000 0,22224228 0,224819 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,22441405 0,22692199 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! gland development GO:0048732 220 91 0,000 0,22441405 0,2268281 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,22657982 0,22892246 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,2287396 0,23100903 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,2287396 0,23091357 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,2287396 0,23081819 ! vitamin metabolic process GO:0006766 153 93 0,000 0,2287396 0,23072289 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,23089341 0,23279926 ! female pregnancy GO:0007565 166 94 0,000 0,23089341 0,23270322 ! sterol metabolic process GO:0016125 166 94 0,000 0,23089341 0,23260726 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,23089341 0,23251138 ! regulation of membrane potential GO:0042391 179 94 0,000 0,23089341 0,23241558 ! regulation of defense response GO:0031347 171 95 0,000 0,23304127 0,23448098 ! nucleosome organization GO:0034728 143 95 0,000 0,23304127 0,23438445 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,23304127 0,23428799 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,23304127 0,23419162 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,23304127 0,23409532 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,23304127 0,23399911 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,23304127 0,23390297 ! response to protein stimulus GO:0051789 158 96 0,000 0,23518319 0,23595587 ! regulation of T cell activation GO:0050863 175 96 0,000 0,23518319 0,235859 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,23731919 0,23790348 ! transcription initiation GO:0006352 171 97 0,000 0,23731919 0,2378059 ! regulation of protein localization GO:0032880 188 97 0,000 0,23731919 0,2377084 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,23944928 0,23974369 ! mRNA transport GO:0051028 185 100 0,000 0,24369182 0,24389148 ! positive regulation of immune response GO:0050778 175 100 0,000 0,24369182 0,24379161 ! hormone metabolic process GO:0042445 171 100 0,000 0,24369182 0,24369182