pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1236-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 3,000 6,999E-09 1,71E-05 ! androgen receptor signaling pathway GO:0030521 81 37 5,000 2,025E-08 2,474E-05 ! steroid hormone receptor signaling pathway GO:0030518 146 66 6,000 2,748E-08 2,238E-05 ! regulation of lipid kinase activity GO:0043550 17 8 3,000 3,242E-08 1,98E-05 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 6,000 4,601E-08 2,248E-05 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 5,000 7,88E-08 3,208E-05 ! regulation of mast cell proliferation GO:0070666 89 49 5,000 1,163E-07 4,058E-05 ! regulation of leukocyte proliferation GO:0070663 97 53 5,000 1,88E-07 5,74E-05 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of B cell proliferation GO:0030888 22 12 3,000 2,259E-07 6,133E-05 ! regulation of B cell activation GO:0050864 55 30 4,000 2,794E-07 6,825E-05 ! negative regulation of protein kinase activity GO:0006469 144 69 5,000 9,224E-07 2,049E-04 ! negative regulation of kinase activity GO:0033673 145 70 5,000 1,005E-06 2,046E-04 ! negative regulation of transferase activity GO:0051348 155 74 5,000 1,398E-06 2,627E-04 ! regulation of T cell differentiation GO:0045580 78 42 4,000 1,593E-06 2,781E-04 ! regulation of T cell proliferation GO:0042129 80 43 4,000 1,796E-06 2,925E-04 ! nuclear migration GO:0007097 13 6 2,000 2,016E-06 3,079E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 2,016E-06 2,898E-04 GO:0031272|regulation of pseudopodium assembly, ! regulation of epithelial cell proliferation GO:0050678 122 45 4,000 2,263E-06 3,071E-04 ! positive regulation of B cell activation GO:0050871 42 22 3,000 3,219E-06 4,138E-04 ! regulation of lymphocyte differentiation GO:0045619 92 49 4,000 3,478E-06 4,249E-04 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 3,000 4,641E-06 5,399E-04 ! negative regulation of phosphorylation GO:0042326 52 24 3,000 4,641E-06 5,154E-04 ! vasculogenesis GO:0001570 49 25 3,000 5,505E-06 5,847E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 5,607E-06 5,707E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 5,607E-06 5,479E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 5,607E-06 5,268E-04 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 3,000 6,482E-06 5,865E-04 GO:0045936|negative regulation of phosphate metabolic process, ! interphase of mitotic cell cycle GO:0051329 224 98 5,000 7,239E-06 6,316E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 8,381E-06 7,06E-04 ! macrophage differentiation GO:0030225 15 9 2,000 8,381E-06 6,825E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 1,193E-05 9,403E-04 ! positive regulation of B cell proliferation GO:0030890 18 10 2,000 1,193E-05 9,109E-04 ! positive regulation of leukocyte migration GO:0002687 28 11 2,000 1,635E-05 1,21E-03 ! nucleus localization GO:0051647 22 11 2,000 1,635E-05 1,175E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 4,000 1,9E-05 1,326E-03 ! regulation of cell projection assembly GO:0060491 33 12 2,000 2,172E-05 1,474E-03 ! regulation of leukocyte migration GO:0002685 29 12 2,000 2,172E-05 1,434E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 2,172E-05 1,397E-03 GO:0042130|negative regulation of T cell proliferation, ! aerobic respiration GO:0009060 56 36 3,000 2,462E-05 1,542E-03 ! regulation of transcription factor activity GO:0051090 137 75 4,000 2,853E-05 1,742E-03 GO:0090046|regulation of transcription regulator activity, ! regulation of protein stability GO:0031647 77 38 3,000 3,063E-05 1,825E-03 ! positive regulation of leukocyte proliferation GO:0070665 70 39 3,000 3,401E-05 1,978E-03 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! catecholamine biosynthetic process GO:0042423 30 14 2,000 3,569E-05 2,028E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 5,454E-05 3,028E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! ATP synthesis coupled electron transport GO:0042773 69 45 3,000 6,026E-05 3,272E-03 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of DNA binding GO:0051101 167 89 4,000 6,508E-05 3,456E-03 ! positive regulation of protein transport GO:0051222 80 46 3,000 6,576E-05 3,418E-03 ! filopodium assembly GO:0046847 42 17 2,000 6,599E-05 3,359E-03 ! regulation of survival gene product expression GO:0045884 38 17 2,000 6,599E-05 3,29E-03 ! negative regulation of microtubule depolymerization GO:0007026 50 17 2,000 6,599E-05 3,224E-03 GO:0031114|regulation of microtubule depolymerization, ! DNA fragmentation involved in apoptosis GO:0006309 27 17 2,000 6,599E-05 3,161E-03 ! regulation of cell cycle process GO:0010564 161 90 4,000 6,864E-05 3,225E-03 ! positive regulation of cell cycle GO:0045787 96 48 3,000 7,784E-05 3,588E-03 ! regulation of immunoglobulin production GO:0002637 49 18 2,000 7,892E-05 3,57E-03 ! defense response to virus GO:0051607 43 18 2,000 7,892E-05 3,505E-03 ! microspike assembly GO:0030035 46 18 2,000 7,892E-05 3,443E-03 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 2,000 7,892E-05 3,382E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 4,000 8,026E-05 3,381E-03 ! regulation of T cell activation GO:0050863 175 96 4,000 9,333E-05 3,865E-03 ! protein export from nucleus GO:0006611 40 19 2,000 9,339E-05 3,803E-03 ! regulation of cell projection organization GO:0031344 135 51 3,000 9,888E-05 3,96E-03 ! negative regulation of immune system process GO:0002683 101 51 3,000 9,888E-05 3,896E-03 ! leukocyte differentiation GO:0002521 232 98 4,000 1,029E-04 3,991E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 1,095E-04 4,18E-03 ! apoptotic mitochondrial changes GO:0008637 42 20 2,000 1,095E-04 4,115E-03 ! negative regulation of T cell activation GO:0050868 41 20 2,000 1,095E-04 4,053E-03 ! respiratory electron transport chain GO:0022904 83 53 3,000 1,15E-04 4,194E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 1,273E-04 4,574E-03 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 2,000 1,273E-04 4,507E-03 ! apoptotic nuclear changes GO:0030262 34 22 2,000 1,469E-04 5,127E-03 ! positive regulation of locomotion GO:0040017 44 22 2,000 1,469E-04 5,055E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of intracellular transport GO:0032388 42 22 2,000 1,469E-04 4,984E-03 ! protein stabilization GO:0050821 41 22 2,000 1,469E-04 4,916E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 3,000 1,529E-04 5,048E-03 ! positive regulation of cell migration GO:0030335 137 58 3,000 1,636E-04 5,33E-03 ! aging GO:0007568 112 58 3,000 1,636E-04 5,26E-03 ! regulation of chemotaxis GO:0050920 45 23 2,000 1,683E-04 5,341E-03 ! establishment of organelle localization GO:0051656 122 59 3,000 1,749E-04 5,478E-03 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 2,000 1,917E-04 5,929E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 2,000 1,917E-04 5,855E-03 ! regulation of homeostatic process GO:0032844 148 62 3,000 2,12E-04 6,395E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 2,171E-04 6,469E-03 ! regulation of behavior GO:0050795 48 25 2,000 2,171E-04 6,391E-03 ! regulation of alpha-beta T cell activation GO:0046634 48 25 2,000 2,171E-04 6,315E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,174E-04 6,248E-03 ! regulation of collagen biosynthetic process GO:0032965 7 5 1,000 2,174E-04 6,176E-03 ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 2,174E-04 6,105E-03 ! protein maturation by protein folding GO:0022417 14 5 1,000 2,174E-04 6,035E-03 ! response to protozoan GO:0001562 13 5 1,000 2,174E-04 5,968E-03 ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 2,174E-04 5,901E-03 ! neutrophil mediated immunity GO:0002446 7 5 1,000 2,174E-04 5,836E-03 ! microvillus organization GO:0032528 8 5 1,000 2,174E-04 5,773E-03 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 1,000 2,174E-04 5,711E-03 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 1,000 2,174E-04 5,65E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 2,174E-04 5,591E-03 ! meiotic chromosome segregation GO:0045132 10 5 1,000 2,174E-04 5,532E-03 ! negative regulation of T cell mediated immunity GO:0002710 15 5 1,000 2,174E-04 5,475E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! decidualization GO:0046697 11 5 1,000 2,174E-04 5,42E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 2,174E-04 5,365E-03 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 1,000 2,174E-04 5,311E-03 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 1,000 2,174E-04 5,259E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 2,174E-04 5,207E-03 ! sequestering of calcium ion GO:0051208 7 5 1,000 2,174E-04 5,156E-03 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 1,000 2,174E-04 5,107E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 1,000 2,174E-04 5,058E-03 ! stem cell division GO:0017145 11 5 1,000 2,174E-04 5,011E-03 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 1,000 2,174E-04 4,964E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 2,398E-04 5,424E-03 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 2,000 2,446E-04 5,482E-03 ! positive regulation of MAPKKK cascade GO:0043410 50 26 2,000 2,446E-04 5,433E-03 ! positive regulation of cell motion GO:0051272 157 65 3,000 2,546E-04 5,603E-03 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 2,7E-04 5,889E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 2,742E-04 5,929E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 2,742E-04 5,877E-03 ! regulation of chromosome organization GO:0033044 49 27 2,000 2,742E-04 5,826E-03 ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 2,742E-04 5,776E-03 ! negative regulation of cell growth GO:0030308 142 67 3,000 2,861E-04 5,974E-03 ! myeloid cell differentiation GO:0030099 126 67 3,000 2,861E-04 5,923E-03 ! cell projection assembly GO:0030031 138 68 3,000 3,029E-04 6,218E-03 ! positive regulation of T cell differentiation GO:0045582 48 28 2,000 3,061E-04 6,231E-03 ! negative regulation of cell size GO:0045792 144 69 3,000 3,203E-04 6,468E-03 ! thymic T cell selection GO:0045061 16 6 1,000 3,251E-04 6,51E-03 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 1,000 3,251E-04 6,457E-03 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 1,000 3,251E-04 6,405E-03 GO:0033135|regulation of peptidyl-serine phosphorylation, ! regulation of immunoglobulin secretion GO:0051023 6 6 1,000 3,251E-04 6,354E-03 ! early endosome to late endosome transport GO:0045022 16 6 1,000 3,251E-04 6,303E-03 ! regulation of collagen metabolic process GO:0010712 10 6 1,000 3,251E-04 6,254E-03 ! establishment of spindle localization GO:0051293 16 6 1,000 3,251E-04 6,205E-03 GO:0051653|spindle localization, ! enucleate erythrocyte differentiation GO:0043353 14 6 1,000 3,251E-04 6,157E-03 ! neutrophil homeostasis GO:0001780 11 6 1,000 3,251E-04 6,109E-03 ! salivary gland morphogenesis GO:0007435 14 6 1,000 3,251E-04 6,063E-03 ! negative regulation of axon extension GO:0030517 24 6 1,000 3,251E-04 6,017E-03 ! triglyceride catabolic process GO:0019433 10 6 1,000 3,251E-04 5,972E-03 ! organ or tissue specific immune response GO:0002251 8 6 1,000 3,251E-04 5,927E-03 ! maternal placenta development GO:0001893 12 6 1,000 3,251E-04 5,883E-03 ! negative regulation of B cell activation GO:0050869 14 6 1,000 3,251E-04 5,84E-03 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 2,000 3,402E-04 6,067E-03 ! catechol metabolic process GO:0009712 55 29 2,000 3,402E-04 6,023E-03 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! regulation of production of molecular mediator of immune response GO:0002700 69 29 2,000 3,402E-04 5,98E-03 ! phenol metabolic process GO:0018958 56 30 2,000 3,767E-04 6,574E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 3,767E-04 6,527E-03 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 3,767E-04 6,481E-03 GO:0043433|negative regulation of transcription factor activity, ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 2,000 4,157E-04 7,101E-03 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 4,157E-04 7,052E-03 ! organelle localization GO:0051640 155 74 3,000 4,187E-04 7,054E-03 ! prostate gland development GO:0030850 14 7 1,000 4,537E-04 7,592E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 4,537E-04 7,541E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 4,537E-04 7,49E-03 ! mRNA stabilization GO:0048255 18 7 1,000 4,537E-04 7,439E-03 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 16 7 1,000 4,537E-04 7,39E-03 GO:0031958|corticosteroid receptor signaling pathway, ! oxaloacetate metabolic process GO:0006107 13 7 1,000 4,537E-04 7,341E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 4,537E-04 7,293E-03 ! positive regulation of isotype switching GO:0045830 17 7 1,000 4,537E-04 7,245E-03 GO:0045911|positive regulation of DNA recombination, ! glycerol ether catabolic process GO:0044269 12 7 1,000 4,537E-04 7,198E-03 GO:0046464|acylglycerol catabolic process, ! regulation of meiosis GO:0040020 12 7 1,000 4,537E-04 7,151E-03 GO:0051445|regulation of meiotic cell cycle, ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 1,000 4,537E-04 7,106E-03 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 1,000 4,537E-04 7,06E-03 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 1,000 4,537E-04 7,016E-03 ! defense response to Gram-negative bacterium GO:0050829 10 7 1,000 4,537E-04 6,971E-03 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 2,000 4,571E-04 6,979E-03 ! spindle organization GO:0007051 50 32 2,000 4,571E-04 6,936E-03 ! positive regulation of T cell proliferation GO:0042102 60 32 2,000 4,571E-04 6,893E-03 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 2,000 4,571E-04 6,851E-03 ! positive regulation of lymphocyte activation GO:0051251 142 78 3,000 5,115E-04 7,62E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 3,000 5,368E-04 7,948E-03 ! negative regulation of organelle organization GO:0010639 181 80 3,000 5,63E-04 8,286E-03 ! positive regulation of phosphorylation GO:0042327 149 81 3,000 5,901E-04 8,633E-03 ! biogenic amine biosynthetic process GO:0042401 65 35 2,000 5,969E-04 8,681E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 6,031E-04 8,718E-03 ! succinate metabolic process GO:0006105 17 8 1,000 6,031E-04 8,667E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 6,031E-04 8,616E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 6,031E-04 8,566E-03 ! glycerolipid catabolic process GO:0046503 14 8 1,000 6,031E-04 8,517E-03 ! ER overload response GO:0006983 13 8 1,000 6,031E-04 8,468E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 6,031E-04 8,419E-03 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 6,031E-04 8,371E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 6,031E-04 8,324E-03 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 1,000 6,031E-04 8,277E-03 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 1,000 6,031E-04 8,231E-03 GO:0002688|regulation of leukocyte chemotaxis, ! myeloid cell homeostasis GO:0002262 15 8 1,000 6,031E-04 8,185E-03 ! trophectodermal cell differentiation GO:0001829 13 8 1,000 6,031E-04 8,14E-03 ! B cell receptor signaling pathway GO:0050853 22 8 1,000 6,031E-04 8,096E-03 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 1,000 6,031E-04 8,051E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 6,031E-04 8,008E-03 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 6,471E-04 8,545E-03 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 2,000 6,49E-04 8,524E-03 ! negative regulation of DNA binding GO:0043392 67 36 2,000 6,49E-04 8,478E-03 ! regulation of ligase activity GO:0051340 147 84 3,000 6,77E-04 8,797E-03 ! regulation of smooth muscle cell proliferation GO:0048660 64 37 2,000 7,038E-04 9,097E-03 ! regulation of microtubule-based process GO:0032886 86 37 2,000 7,038E-04 9,05E-03 ! negative regulation of cell activation GO:0050866 69 37 2,000 7,038E-04 9,002E-03 ! negative regulation of growth GO:0045926 168 85 3,000 7,078E-04 9,006E-03 ! cellular response to hormone stimulus GO:0032870 182 85 3,000 7,078E-04 8,96E-03 ! positive regulation of cell activation GO:0050867 161 86 3,000 7,397E-04 9,314E-03 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 7,615E-04 9,54E-03 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 2,000 7,615E-04 9,492E-03 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 7,615E-04 9,444E-03 ! regulation of protein transport GO:0051223 165 87 3,000 7,725E-04 9,531E-03 GO:0070201|regulation of establishment of protein localization, ! neutral lipid catabolic process GO:0046461 14 9 1,000 7,73E-04 9,49E-03 ! induction of positive chemotaxis GO:0050930 17 9 1,000 7,73E-04 9,443E-03 ! microtubule bundle formation GO:0001578 22 9 1,000 7,73E-04 9,396E-03 ! middle ear morphogenesis GO:0042474 14 9 1,000 7,73E-04 9,349E-03 ! T cell selection GO:0045058 27 9 1,000 7,73E-04 9,303E-03 ! receptor clustering GO:0043113 20 9 1,000 7,73E-04 9,257E-03 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 1,000 7,73E-04 9,212E-03 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 1,000 7,73E-04 9,167E-03 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage differentiation GO:0045649 16 9 1,000 7,73E-04 9,123E-03 ! regulation of telomere maintenance GO:0032204 17 9 1,000 7,73E-04 9,079E-03 ! cellular respiration GO:0045333 143 88 3,000 8,063E-04 9,425E-03 ! negative regulation of binding GO:0051100 71 39 2,000 8,221E-04 9,564E-03 ! oxidative phosphorylation GO:0006119 152 90 3,000 8,772E-04 0,01015587 ! nucleus organization GO:0006997 73 40 2,000 8,857E-04 0,01020694 ! gland development GO:0048732 220 91 3,000 9,142E-04 0,0104849 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 9,524E-04 0,01087237 ! lung alveolus development GO:0048286 26 10 1,000 9,633E-04 0,01094576 ! regulation of chemokine biosynthetic process GO:0045073 12 10 1,000 9,633E-04 0,01089509 ! positive regulation of survival gene product expression GO:0045885 26 10 1,000 9,633E-04 0,01084488 ! myeloid leukocyte mediated immunity GO:0002444 14 10 1,000 9,633E-04 0,01079513 ! phosphagen metabolic process GO:0006599 17 10 1,000 9,633E-04 0,01074584 GO:0006600|creatine metabolic process, ! motor axon guidance GO:0008045 22 10 1,000 9,633E-04 0,01069699 ! regulation of bone resorption GO:0045124 25 10 1,000 9,633E-04 0,01064859 ! positive regulation of phagocytosis GO:0050766 14 10 1,000 9,633E-04 0,01060063 ! regulation of B cell differentiation GO:0045577 24 10 1,000 9,633E-04 0,01055309 ! positive regulation of interleukin-6 production GO:0032755 14 10 1,000 9,633E-04 0,01050598 ! spinal cord motor neuron differentiation GO:0021522 19 10 1,000 9,633E-04 0,01045928 ! salivary gland development GO:0007431 28 10 1,000 9,633E-04 0,010413 ! positive regulation of acute inflammatory response GO:0002675 18 10 1,000 9,633E-04 0,01036713 ! blastocyst formation GO:0001825 18 10 1,000 9,633E-04 0,01032166 ! negative regulation of immune effector process GO:0002698 23 10 1,000 9,633E-04 0,01027659 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 9,633E-04 0,01023191 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 2,000 1,022E-03 0,01080979 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 1,022E-03 0,0107632 ! T cell differentiation GO:0030217 93 42 2,000 1,022E-03 0,010717 ! positive regulation of transcription factor activity GO:0051091 71 43 2,000 1,095E-03 0,01143217 GO:0090047|positive regulation of transcription regulator activity, ! regulation of DNA metabolic process GO:0051052 188 97 3,000 1,16E-03 0,01205459 ! transcription initiation GO:0006352 171 97 3,000 1,16E-03 0,01200351 ! regulation of protein localization GO:0032880 188 97 3,000 1,16E-03 0,01195286 ! negative regulation of protein complex disassembly GO:0043242 113 44 2,000 1,171E-03 0,01202109 ! positive regulation of response to external stimulus GO:0032103 88 44 2,000 1,171E-03 0,01197079 ! neuron fate specification GO:0048665 18 11 1,000 1,174E-03 0,01194761 ! cortical actin cytoskeleton organization GO:0030866 29 11 1,000 1,174E-03 0,01189804 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 1,174E-03 0,01184887 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 1,174E-03 0,01180011 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,174E-03 0,01175175 ! blood vessel remodeling GO:0001974 30 11 1,000 1,174E-03 0,01170379 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 1,000 1,174E-03 0,01165621 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 1,174E-03 0,01160902 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,174E-03 0,01156221 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 1,000 1,174E-03 0,01151577 ! negative regulation of axonogenesis GO:0050771 37 11 1,000 1,174E-03 0,01146971 ! positive regulation of T cell mediated immunity GO:0002711 26 11 1,000 1,174E-03 0,01142401 ! DNA methylation GO:0006306 19 11 1,000 1,174E-03 0,01137868 GO:0006305|DNA alkylation, ! regulation of isotype switching GO:0045191 24 11 1,000 1,174E-03 0,0113337 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 1,000 1,174E-03 0,01128908 ! T cell receptor signaling pathway GO:0050852 29 11 1,000 1,174E-03 0,01124481 ! sequestering of metal ion GO:0051238 15 11 1,000 1,174E-03 0,01120089 ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 1,25E-03 0,01188662 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 2,000 1,25E-03 0,01184055 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 1,333E-03 0,01257445 ! cortical cytoskeleton organization GO:0030865 30 12 1,000 1,404E-03 0,01319346 ! regulation of positive chemotaxis GO:0050926 22 12 1,000 1,404E-03 0,01314291 GO:0050927|positive regulation of positive chemotaxis, ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 1,404E-03 0,01309274 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 1,404E-03 0,01304296 ! T cell proliferation GO:0042098 32 12 1,000 1,404E-03 0,01299356 ! ventral spinal cord development GO:0021517 25 12 1,000 1,404E-03 0,01294452 ! focal adhesion formation GO:0048041 37 12 1,000 1,404E-03 0,01289586 ! mitotic spindle organization GO:0007052 23 12 1,000 1,404E-03 0,01284756 ! entry into host cell GO:0030260 34 12 1,000 1,404E-03 0,01279962 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! regulation of phagocytosis GO:0050764 17 12 1,000 1,404E-03 0,01275204 ! histone acetylation GO:0016573 27 12 1,000 1,404E-03 0,01270481 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,404E-03 0,01265793 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 1,404E-03 0,01261139 ! defense response to Gram-positive bacterium GO:0050830 14 12 1,000 1,404E-03 0,0125652 ! embryonic placenta development GO:0001892 21 12 1,000 1,404E-03 0,01251934 ! localization within membrane GO:0051668 26 12 1,000 1,404E-03 0,01247381 ! response to insulin stimulus GO:0032868 98 47 2,000 1,419E-03 0,01256126 ! regulation of JAK-STAT cascade GO:0046425 76 48 2,000 1,509E-03 0,01330453 ! cellular component disassembly GO:0022411 89 48 2,000 1,509E-03 0,01325668 ! positive regulation of DNA binding GO:0043388 83 48 2,000 1,509E-03 0,01320916 ! regulation of adaptive immune response GO:0002819 92 48 2,000 1,509E-03 0,01316199 ! response to calcium ion GO:0051592 94 49 2,000 1,601E-03 0,0139226 ! negative regulation of cell projection organization GO:0031345 42 13 1,000 1,654E-03 0,01433152 ! regulation of chemokine production GO:0032642 18 13 1,000 1,654E-03 0,01428088 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 1,654E-03 0,01423059 GO:0000725|recombinational repair, ! cartilage condensation GO:0001502 22 13 1,000 1,654E-03 0,01418066 ! endocrine pancreas development GO:0031018 25 13 1,000 1,654E-03 0,01413108 ! plasma membrane organization GO:0007009 27 13 1,000 1,654E-03 0,01408184 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 1,654E-03 0,01403295 ! exocrine system development GO:0035272 34 13 1,000 1,654E-03 0,01398439 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 1,654E-03 0,01393617 ! gland morphogenesis GO:0022612 31 13 1,000 1,654E-03 0,01388828 ! regulation of acute inflammatory response GO:0002673 24 13 1,000 1,654E-03 0,01384071 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 1,000 1,654E-03 0,01379348 ! regulation of mRNA stability GO:0043488 32 13 1,000 1,654E-03 0,01374656 ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 1,654E-03 0,01369996 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 1,698E-03 0,01401252 ! activation of caspase activity GO:0006919 95 50 2,000 1,698E-03 0,01396534 ! positive regulation of binding GO:0051099 88 52 2,000 1,901E-03 0,01558645 ! regulation of protein complex disassembly GO:0043244 127 52 2,000 1,901E-03 0,01553432 ! regulation of S phase GO:0033261 26 14 1,000 1,924E-03 0,01566846 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 1,000 1,924E-03 0,0156164 ! T cell differentiation in the thymus GO:0033077 37 14 1,000 1,924E-03 0,01556469 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 1,000 1,924E-03 0,01551332 ! regulation of T-helper 2 type immune response GO:0002828 25 14 1,000 1,924E-03 0,01546229 ! regulation of RNA stability GO:0043487 33 14 1,000 1,924E-03 0,0154116 ! regulation of axon extension GO:0030516 43 14 1,000 1,924E-03 0,01536123 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 1,924E-03 0,01531119 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 2,000 2,008E-03 0,01593048 ! regulation of angiogenesis GO:0045765 125 54 2,000 2,119E-03 0,01675542 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 2,213E-03 0,01744188 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 2,213E-03 0,0173858 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 1,000 2,213E-03 0,01733008 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 2,213E-03 0,01727471 ! regulation of T cell mediated immunity GO:0002709 36 15 1,000 2,213E-03 0,0172197 ! response to UV GO:0009411 120 55 2,000 2,234E-03 0,01732501 ! negative regulation of cytoskeleton organization GO:0051494 139 56 2,000 2,352E-03 0,01818529 ! regulation of bone remodeling GO:0046850 143 57 2,000 2,474E-03 0,01906956 ! positive regulation of caspase activity GO:0043280 108 57 2,000 2,474E-03 0,01900959 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 108 57 2,000 2,474E-03 0,01895 ! negative regulation of immune response GO:0050777 38 16 1,000 2,522E-03 0,01925118 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 2,522E-03 0,01919121 ! neuron recognition GO:0008038 40 16 1,000 2,522E-03 0,01913161 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 2,522E-03 0,01907238 ! regulation of T-helper cell differentiation GO:0045622 30 16 1,000 2,522E-03 0,01901351 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 1,000 2,522E-03 0,01895501 ! regulation of tissue remodeling GO:0034103 146 58 2,000 2,6E-03 0,01948765 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 2,000 2,6E-03 0,01942805 ! maintenance of location GO:0051235 124 58 2,000 2,6E-03 0,01936882 ! nuclear export GO:0051168 110 59 2,000 2,73E-03 0,02027484 ! positive regulation of cell killing GO:0031343 36 17 1,000 2,849E-03 0,02109171 ! negative regulation of hormone secretion GO:0046888 26 17 1,000 2,849E-03 0,02102799 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 2,849E-03 0,02096465 ! signal complex assembly GO:0007172 47 17 1,000 2,849E-03 0,0209017 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 1,000 2,849E-03 0,02083912 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 1,000 2,849E-03 0,02077691 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 1,000 2,849E-03 0,02071507 GO:0002712|regulation of B cell mediated immunity, ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 2,849E-03 0,0206536 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 2,849E-03 0,0205925 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 1,000 2,849E-03 0,02053175 ! DNA catabolic process GO:0006308 94 60 2,000 2,864E-03 0,02058085 ! cytokine-mediated signaling pathway GO:0019221 112 61 2,000 3,002E-03 0,02150812 ! positive regulation of anti-apoptosis GO:0045768 47 18 1,000 3,195E-03 0,02282514 ! cell-substrate junction assembly GO:0007044 56 18 1,000 3,195E-03 0,02275859 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 3,195E-03 0,02269243 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 3,195E-03 0,02262666 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 1,000 3,195E-03 0,02256126 ! regulation of protein complex assembly GO:0043254 132 63 2,000 3,29E-03 0,02316237 ! skeletal system morphogenesis GO:0048705 118 63 2,000 3,29E-03 0,02309581 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 3,44E-03 0,0240797 ! positive regulation of translation GO:0045727 31 19 1,000 3,56E-03 0,02485066 ! cell differentiation in spinal cord GO:0021515 37 19 1,000 3,56E-03 0,02477986 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 3,56E-03 0,02470946 ! neuromuscular junction development GO:0007528 43 19 1,000 3,56E-03 0,02463947 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 3,56E-03 0,02456986 ! peptide cross-linking GO:0018149 39 19 1,000 3,56E-03 0,02450065 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 1,000 3,56E-03 0,02443183 ! proximal/distal pattern formation GO:0009954 33 19 1,000 3,56E-03 0,02436339 ! peptide hormone secretion GO:0030072 32 19 1,000 3,56E-03 0,02429534 ! activation of MAPK activity GO:0000187 124 67 2,000 3,915E-03 0,02664069 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 3,944E-03 0,02676229 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 3,944E-03 0,02668815 ! protein amino acid acetylation GO:0006473 41 20 1,000 3,944E-03 0,02661443 ! response to alkaloid GO:0043279 38 20 1,000 3,944E-03 0,02654111 ! pancreas development GO:0031016 40 20 1,000 3,944E-03 0,0264682 ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 3,944E-03 0,02639568 ! actin filament bundle formation GO:0051017 47 20 1,000 3,944E-03 0,02632356 ! peptide secretion GO:0002790 38 20 1,000 3,944E-03 0,02625184 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 1,000 3,944E-03 0,0261805 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 1,000 3,944E-03 0,02610955 ! negative regulation of translation GO:0017148 32 20 1,000 3,944E-03 0,02603898 ! positive regulation of T cell activation GO:0050870 124 68 2,000 4,082E-03 0,02687675 ! lung development GO:0030324 165 69 2,000 4,253E-03 0,02792727 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 2,000 4,253E-03 0,0278524 ! urogenital system development GO:0001655 149 69 2,000 4,253E-03 0,02777792 ! homeostasis of number of cells GO:0048872 131 69 2,000 4,253E-03 0,02770385 ! regulation of cell killing GO:0031341 46 21 1,000 4,345E-03 0,02823361 ! hormone secretion GO:0046879 39 21 1,000 4,345E-03 0,02815872 ! lipid phosphorylation GO:0046834 43 21 1,000 4,345E-03 0,02808422 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 4,345E-03 0,02801012 ! positive regulation of inflammatory response GO:0050729 41 21 1,000 4,345E-03 0,02793641 ! positive regulation of osteoblast differentiation GO:0045669 52 21 1,000 4,345E-03 0,02786309 ! cell cycle checkpoint GO:0000075 145 71 2,000 4,607E-03 0,02946543 ! cell aging GO:0007569 48 22 1,000 4,765E-03 0,03039565 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 1,000 4,765E-03 0,03031649 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 1,000 4,765E-03 0,03023775 ! G1 phase GO:0051318 44 22 1,000 4,765E-03 0,03015941 ! positive regulation of adaptive immune response GO:0002821 42 22 1,000 4,765E-03 0,03008148 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 4,765E-03 0,03000395 ! peptidyl-serine modification GO:0018209 50 22 1,000 4,765E-03 0,02992682 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 4,765E-03 0,02985008 ! respiratory tube development GO:0030323 171 72 2,000 4,791E-03 0,02993638 ! actin filament organization GO:0007015 167 72 2,000 4,791E-03 0,02986001 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 2,000 4,791E-03 0,02978403 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 2,000 4,791E-03 0,02970844 ! regulation of MAPKKK cascade GO:0043408 157 72 2,000 4,791E-03 0,02963323 ! regulation of immune effector process GO:0002697 156 73 2,000 4,98E-03 0,03072009 ! regulation of caspase activity GO:0043281 136 74 2,000 5,172E-03 0,03182862 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 5,172E-03 0,03174865 ! respiratory system development GO:0060541 175 74 2,000 5,172E-03 0,03166908 ! positive regulation of DNA replication GO:0045740 44 23 1,000 5,203E-03 0,0317777 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 5,203E-03 0,03169846 ! regulation of anti-apoptosis GO:0045767 62 23 1,000 5,203E-03 0,0316196 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 5,203E-03 0,03154114 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 1,000 5,203E-03 0,03146307 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 5,203E-03 0,03138538 ! cellular response to reactive oxygen species GO:0034614 35 23 1,000 5,203E-03 0,03130808 ! regulation of interleukin-6 production GO:0032675 31 23 1,000 5,203E-03 0,03123116 ! DNA modification GO:0006304 36 23 1,000 5,203E-03 0,03115461 ! hormone transport GO:0009914 41 23 1,000 5,203E-03 0,03107844 ! response to molecule of bacterial origin GO:0002237 40 23 1,000 5,203E-03 0,03100264 ! reproductive structure development GO:0048608 131 75 2,000 5,369E-03 0,03191632 ! eye development GO:0001654 155 75 2,000 5,369E-03 0,03183885 ! cell-matrix adhesion GO:0007160 181 76 2,000 5,571E-03 0,03295438 ! lymphocyte differentiation GO:0030098 193 76 2,000 5,571E-03 0,03287478 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 5,659E-03 0,03331096 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 5,659E-03 0,03323089 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 5,659E-03 0,0331512 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 1,000 5,659E-03 0,03307189 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to corticosteroid stimulus GO:0031960 46 24 1,000 5,659E-03 0,03299296 ! sex determination GO:0007530 48 24 1,000 5,659E-03 0,03291441 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 1,000 5,659E-03 0,03283622 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 5,659E-03 0,03275841 ! platelet activation GO:0030168 41 24 1,000 5,659E-03 0,03268097 ! negative regulation of catabolic process GO:0009895 52 24 1,000 5,659E-03 0,03260389 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 5,777E-03 0,03320867 ! positive regulation of ligase activity GO:0051351 130 77 2,000 5,777E-03 0,03313072 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 6,132E-03 0,035082 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 6,132E-03 0,03500004 ! leukocyte adhesion GO:0007159 55 25 1,000 6,132E-03 0,03491845 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 6,132E-03 0,03483724 ! receptor metabolic process GO:0043112 53 25 1,000 6,132E-03 0,03475642 ! interaction with host GO:0051701 66 25 1,000 6,132E-03 0,03467596 ! lymphocyte proliferation GO:0046651 55 25 1,000 6,132E-03 0,03459588 ! immunoglobulin production GO:0002377 62 25 1,000 6,132E-03 0,03451616 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 1,000 6,132E-03 0,03443682 ! leukocyte homeostasis GO:0001776 50 25 1,000 6,132E-03 0,03435783 ! blood coagulation GO:0007596 151 79 2,000 6,203E-03 0,03467714 GO:0050817|coagulation, ! myelination GO:0042552 50 26 1,000 6,622E-03 0,03693733 ! initiation of viral infection GO:0019059 60 26 1,000 6,622E-03 0,03685319 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 6,622E-03 0,03676944 ! spinal cord development GO:0021510 54 26 1,000 6,622E-03 0,03668606 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 6,622E-03 0,03660306 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 6,622E-03 0,03652043 ! negative regulation of cell development GO:0010721 83 26 1,000 6,622E-03 0,03643818 GO:0050768|negative regulation of neurogenesis, ! positive regulation of nuclear division GO:0051785 41 26 1,000 6,622E-03 0,0363563 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 6,622E-03 0,03627478 ! blastocyst development GO:0001824 50 26 1,000 6,622E-03 0,03619363 ! meiosis GO:0007126 143 81 2,000 6,647E-03 0,03624726 GO:0051327|M phase of meiotic cell cycle, ! response to hypoxia GO:0001666 178 81 2,000 6,647E-03 0,03616653 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 2,000 6,647E-03 0,03608616 ! regulation of peptidase activity GO:0052547 150 82 2,000 6,876E-03 0,03724632 ! cell-substrate adhesion GO:0031589 189 82 2,000 6,876E-03 0,03716391 ! meiotic cell cycle GO:0051321 144 82 2,000 6,876E-03 0,03708187 ! response to oxygen levels GO:0070482 183 83 2,000 7,11E-03 0,03825713 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 7,13E-03 0,03828404 ! cellular response to oxidative stress GO:0034599 43 27 1,000 7,13E-03 0,03820009 ! leukocyte proliferation GO:0070661 59 27 1,000 7,13E-03 0,0381165 GO:0032943|mononuclear cell proliferation, ! response to metal ion GO:0010038 158 84 2,000 7,348E-03 0,03919382 ! T cell activation GO:0042110 189 84 2,000 7,348E-03 0,03910843 ! hemostasis GO:0007599 165 85 2,000 7,591E-03 0,04031357 ! negative regulation of transport GO:0051051 164 85 2,000 7,591E-03 0,04022612 ! regulation of neuron differentiation GO:0045664 187 85 2,000 7,591E-03 0,04013905 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 7,655E-03 0,04039235 ! neuron fate commitment GO:0048663 52 28 1,000 7,655E-03 0,0403053 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 7,655E-03 0,04021862 ! protein amino acid acylation GO:0043543 59 28 1,000 7,655E-03 0,04013232 ! dendrite development GO:0016358 67 28 1,000 7,655E-03 0,04004638 ! negative regulation of protein modification process GO:0031400 66 28 1,000 7,655E-03 0,03996081 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 7,655E-03 0,03987561 ! mitochondrion organization GO:0007005 159 87 2,000 8,091E-03 0,04205469 ! cellular iron ion homeostasis GO:0006879 57 29 1,000 8,197E-03 0,04251677 ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 8,197E-03 0,04242669 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 8,197E-03 0,042337 ! somitogenesis GO:0001756 52 29 1,000 8,197E-03 0,04224768 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 8,197E-03 0,04215873 ! amine biosynthetic process GO:0009309 146 88 2,000 8,348E-03 0,0428441 ! one-carbon metabolic process GO:0006730 167 88 2,000 8,348E-03 0,04275428 ! acute-phase response GO:0006953 50 30 1,000 8,756E-03 0,04474905 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 1,000 8,756E-03 0,04465563 ! immune response-activating signal transduction GO:0002757 58 30 1,000 8,756E-03 0,04456259 GO:0002764|immune response-regulating signal transduction, ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 8,756E-03 0,04446995 ! response to inorganic substance GO:0010035 173 90 2,000 8,876E-03 0,04498945 ! positive regulation of protein modification process GO:0031401 156 90 2,000 8,876E-03 0,0448963 ! ossification GO:0001503 205 91 2,000 9,148E-03 0,04617363 ! cell junction assembly GO:0034329 85 31 1,000 9,331E-03 0,04700039 ! peptide transport GO:0015833 60 31 1,000 9,331E-03 0,04690368 ! male gonad development GO:0008584 56 31 1,000 9,331E-03 0,04680737 ! iron ion homeostasis GO:0055072 60 31 1,000 9,331E-03 0,04671145 ! erythrocyte differentiation GO:0030218 62 31 1,000 9,331E-03 0,04661593 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 9,331E-03 0,04652079 ! ensheathment of neurons GO:0007272 64 31 1,000 9,331E-03 0,04642605 GO:0008366|axon ensheathment, ! positive regulation of immune effector process GO:0002699 78 31 1,000 9,331E-03 0,04633168 ! bone development GO:0060348 206 92 2,000 9,424E-03 0,04669965 ! regulation of cell adhesion GO:0030155 241 92 2,000 9,424E-03 0,04660511 ! regulation of cell morphogenesis GO:0022604 243 93 2,000 9,705E-03 0,04789823 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 1,000 9,922E-03 0,04887182 ! metanephros development GO:0001656 81 32 1,000 9,922E-03 0,04877349 ! response to mechanical stimulus GO:0009612 60 32 1,000 9,922E-03 0,04867555 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 9,922E-03 0,048578 ! peripheral nervous system development GO:0007422 68 32 1,000 9,922E-03 0,04848085 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 0,01028186 0,0501369 ! triglyceride metabolic process GO:0006641 46 33 1,000 0,01053023 0,05124572 ! regulation of axonogenesis GO:0050770 86 33 1,000 0,01053023 0,05114384 ! leukocyte chemotaxis GO:0030595 55 33 1,000 0,01053023 0,05104236 GO:0060326|cell chemotaxis, ! negative regulation of protein transport GO:0051224 74 33 1,000 0,01053023 0,05094129 ! sex differentiation GO:0007548 171 96 2,000 0,01057754 0,05106904 ! biogenic amine metabolic process GO:0006576 162 97 2,000 0,01087811 0,05241663 ! cell fate specification GO:0001708 56 34 1,000 0,01115414 0,05364087 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 0,01115414 0,05353549 ! negative regulation of secretion GO:0051048 68 35 1,000 0,01179397 0,05649543 ! positive regulation of endocytosis GO:0045807 56 35 1,000 0,01179397 0,05638487 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,01179397 0,05627474 ! placenta development GO:0001890 53 35 1,000 0,01179397 0,05616504 ! skeletal muscle tissue development GO:0007519 223 100 2,000 0,01180934 0,05612881 GO:0060538|skeletal muscle organ development, ! mitotic sister chromatid segregation GO:0000070 63 36 1,000 0,01244956 0,05905683 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 1,000 0,01244956 0,05894238 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 0,01312074 0,06199995 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! negative regulation of cell adhesion GO:0007162 94 37 1,000 0,01312074 0,06188026 ! sister chromatid segregation GO:0000819 65 37 1,000 0,01312074 0,06176103 ! cell junction organization GO:0034330 96 37 1,000 0,01312074 0,06164226 ! tissue remodeling GO:0048771 78 37 1,000 0,01312074 0,06152394 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,01312074 0,06140608 ! meiosis I GO:0007127 74 38 1,000 0,01380737 0,06449598 ! neutral lipid metabolic process GO:0006638 54 38 1,000 0,01380737 0,0643729 GO:0006639|acylglycerol metabolic process, ! glycogen metabolic process GO:0005977 63 38 1,000 0,01380737 0,06425028 ! regulation of neuron projection development GO:0010975 102 39 1,000 0,01450927 0,06738812 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 1,000 0,01450927 0,06726025 ! erythrocyte homeostasis GO:0034101 75 39 1,000 0,01450927 0,06713286 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 1,000 0,01450927 0,06700595 ! glucan metabolic process GO:0044042 64 39 1,000 0,01450927 0,06687953 GO:0006073|cellular glucan metabolic process, ! mammary gland development GO:0030879 93 40 1,000 0,0152263 0,07005245 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,0152263 0,06992077 ! glycerol ether metabolic process GO:0006662 57 40 1,000 0,0152263 0,06978958 ! RNA export from nucleus GO:0006405 61 41 1,000 0,01595829 0,0730077 ! regulation of hormone secretion GO:0046883 69 41 1,000 0,01595829 0,07287124 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,01595829 0,07273529 ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,01595829 0,07259984 ! maintenance of protein location GO:0045185 95 41 1,000 0,01595829 0,07246489 ! ear morphogenesis GO:0042471 64 42 1,000 0,0167051 0,07571534 ! organic ether metabolic process GO:0018904 59 42 1,000 0,0167051 0,07557512 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,0167051 0,07543543 ! regulation of protein secretion GO:0050708 77 42 1,000 0,0167051 0,07529625 ! cytokinesis GO:0000910 84 42 1,000 0,0167051 0,07515758 ! epithelial cell differentiation GO:0030855 83 43 1,000 0,01746657 0,07843903 ! glucose transport GO:0015758 66 43 1,000 0,01746657 0,0782951 ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,01746657 0,0781517 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,01746657 0,07800883 ! segmentation GO:0035282 78 43 1,000 0,01746657 0,07786648 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 0,01746657 0,07772465 ! response to reactive oxygen species GO:0000302 75 44 1,000 0,01824254 0,08103007 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,01824254 0,08088301 ! hexose transport GO:0008645 68 44 1,000 0,01824254 0,08073648 GO:0015749|monosaccharide transport, ! double-strand break repair GO:0006302 85 44 1,000 0,01824254 0,08059048 ! keratinocyte differentiation GO:0030216 81 45 1,000 0,01903287 0,08393017 ! biopolymer methylation GO:0043414 91 45 1,000 0,01903287 0,08377894 ! maintenance of location in cell GO:0051651 101 45 1,000 0,01903287 0,08362826 ! glycolysis GO:0006096 71 46 1,000 0,01983741 0,0870068 ! leukocyte migration GO:0050900 75 46 1,000 0,01983741 0,08685088 ! pigmentation GO:0043473 103 46 1,000 0,01983741 0,08669551 ! cell growth GO:0016049 90 46 1,000 0,01983741 0,0865407 ! positive regulation of defense response GO:0031349 88 48 1,000 0,0214885 0,09357647 ! endosome transport GO:0016197 127 48 1,000 0,0214885 0,09340997 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,0214885 0,09324405 ! male sex differentiation GO:0046661 93 48 1,000 0,0214885 0,09307873 ! regulation of inflammatory response GO:0050727 84 48 1,000 0,0214885 0,09291398 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,0214885 0,09274982 ! methylation GO:0032259 97 48 1,000 0,0214885 0,09258624 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 0,02233476 0,09606305 ! regulation of action potential GO:0001508 102 50 1,000 0,02319463 0,09958609 ! endocrine system development GO:0035270 109 50 1,000 0,02319463 0,09941137 ! regulation of ossification GO:0030278 123 50 1,000 0,02319463 0,09923727 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,02319463 0,09906378 ! epidermal cell differentiation GO:0009913 87 50 1,000 0,02319463 0,09889089 ! positive regulation of cytokine production GO:0001819 94 50 1,000 0,02319463 0,09871861 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02327359 0,09888241 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02327359 0,09871074 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02327359 0,09853966 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02327359 0,09836918 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02327359 0,09819928 ! neuron fate determination GO:0048664 7 5 0,000 0,02327359 0,09802998 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02327359 0,09786125 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02327359 0,0976931 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02327359 0,09752553 ! polyol transport GO:0015791 12 5 0,000 0,02327359 0,09735854 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02327359 0,09719211 ! response to superoxide GO:0000303 10 5 0,000 0,02327359 0,09702626 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02327359 0,09686096 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02327359 0,09669623 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02327359 0,09653206 ! female meiosis GO:0007143 10 5 0,000 0,02327359 0,09636845 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02327359 0,09620539 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02327359 0,09604288 ! hypothalamus development GO:0021854 9 5 0,000 0,02327359 0,09588092 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02327359 0,0957195 ! cobalt ion transport GO:0006824 11 5 0,000 0,02327359 0,09555863 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02327359 0,0953983 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02327359 0,0952385 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02327359 0,09507924 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02327359 0,09492051 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02327359 0,09476231 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02327359 0,09460463 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02327359 0,09444748 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02327359 0,09429085 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! transposition GO:0032196 9 5 0,000 0,02327359 0,09413474 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,02327359 0,09397915 ! negative chemotaxis GO:0050919 16 5 0,000 0,02327359 0,09382407 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02327359 0,0936695 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02327359 0,09351544 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02327359 0,09336188 ! behavioral response to pain GO:0048266 10 5 0,000 0,02327359 0,09320883 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02327359 0,09305628 ! Notch receptor processing GO:0007220 11 5 0,000 0,02327359 0,09290422 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02327359 0,09275267 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02327359 0,09260161 ! micturition GO:0060073 9 5 0,000 0,02327359 0,09245103 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02327359 0,09230095 ! copulation GO:0007620 9 5 0,000 0,02327359 0,09215135 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02327359 0,09200224 ! bioluminescence GO:0008218 9 5 0,000 0,02327359 0,09185361 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02327359 0,09170546 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02327359 0,09155779 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02327359 0,09141059 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02327359 0,09126386 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02327359 0,09111761 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02327359 0,09097182 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02327359 0,09082649 ! grooming behavior GO:0007625 6 5 0,000 0,02327359 0,09068164 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02327359 0,09053724 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02327359 0,0903933 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02327359 0,09024982 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02327359 0,09010679 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,02327359 0,08996422 ! lymph vessel development GO:0001945 10 5 0,000 0,02327359 0,08982209 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02327359 0,08968042 ! endochondral ossification GO:0001958 17 5 0,000 0,02327359 0,08953919 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02327359 0,0893984 ! single strand break repair GO:0000012 8 5 0,000 0,02327359 0,08925806 ! parathyroid gland development GO:0060017 14 5 0,000 0,02327359 0,08911816 ! anagen GO:0042640 7 5 0,000 0,02327359 0,08897869 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02327359 0,08883966 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02327359 0,08870107 ! cytokine secretion GO:0050663 15 5 0,000 0,02327359 0,08856291 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02327359 0,08842517 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02327359 0,08828787 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02327359 0,08815099 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02327359 0,08801453 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02327359 0,08787849 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02327359 0,08774288 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02327359 0,08760768 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02327359 0,0874729 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02327359 0,08733853 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02327359 0,08720458 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02327359 0,08707103 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02327359 0,0869379 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02327359 0,08680517 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02327359 0,08667284 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02327359 0,08654092 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02327359 0,0864094 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02327359 0,08627828 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02327359 0,08614755 ! polyol catabolic process GO:0046174 9 5 0,000 0,02327359 0,08601722 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02327359 0,08588729 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02327359 0,08575775 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02327359 0,08562859 ! muscle cell migration GO:0014812 8 5 0,000 0,02327359 0,08549983 ! mitochondrial fission GO:0000266 8 5 0,000 0,02327359 0,08537145 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02327359 0,08524346 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02327359 0,08511585 ! mRNA transcription GO:0009299 10 5 0,000 0,02327359 0,08498862 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02327359 0,08486177 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02327359 0,0847353 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02327359 0,0846092 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02327359 0,08448349 ! monocyte activation GO:0042117 10 5 0,000 0,02327359 0,08435814 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02327359 0,08423316 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02327359 0,08410856 ! response to food GO:0032094 6 5 0,000 0,02327359 0,08398432 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02327359 0,08386045 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02327359 0,08373694 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02327359 0,0836138 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02327359 0,08349102 ! forebrain neuron development GO:0021884 13 5 0,000 0,02327359 0,0833686 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02327359 0,08324654 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02327359 0,08312483 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02327359 0,08300348 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02327359 0,08288249 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02327359 0,08276184 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02327359 0,08264155 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02327359 0,0825216 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02327359 0,08240201 ! lipid glycosylation GO:0030259 7 5 0,000 0,02327359 0,08228276 ! nucleobase transport GO:0015851 6 5 0,000 0,02327359 0,08216385 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02327359 0,08204529 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02327359 0,08192707 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02327359 0,08180919 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02327359 0,08169165 ! basic amino acid transport GO:0015802 12 5 0,000 0,02327359 0,08157444 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02327359 0,08145757 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02327359 0,08134104 ! actin nucleation GO:0045010 11 5 0,000 0,02327359 0,08122484 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02327359 0,08110897 ! depurination GO:0045007 5 5 0,000 0,02327359 0,08099343 ! depyrimidination GO:0045008 10 5 0,000 0,02327359 0,08087822 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02327359 0,08076333 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02327359 0,08064877 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02327359 0,08053454 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02327359 0,08042063 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02327359 0,08030704 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02327359 0,08019377 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02327359 0,08008082 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02327359 0,07996819 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02327359 0,07985588 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02327359 0,07974388 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02327359 0,07963219 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02327359 0,07952082 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02327359 0,07940976 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02327359 0,079299 ! response to arsenic GO:0046685 11 5 0,000 0,02327359 0,07918856 ! mast cell degranulation GO:0043303 7 5 0,000 0,02327359 0,07907842 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02327359 0,07896859 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02327359 0,07885906 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02327359 0,07874984 ! response to mercury ion GO:0046689 8 5 0,000 0,02327359 0,07864092 ! response to cadmium ion GO:0046686 7 5 0,000 0,02327359 0,0785323 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02327359 0,07842398 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02327359 0,07831596 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02327359 0,07820823 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02327359 0,0781008 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02327359 0,07799367 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02327359 0,07788683 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02327359 0,07778028 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02327359 0,07767402 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02327359 0,07756806 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02327359 0,07746238 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02327359 0,07735699 ! embryonic cleavage GO:0040016 6 5 0,000 0,02327359 0,07725188 ! peroxisome fission GO:0016559 5 5 0,000 0,02327359 0,07714706 ! histone demethylation GO:0016577 13 5 0,000 0,02327359 0,07704253 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02327359 0,07693828 ! mitotic recombination GO:0006312 9 5 0,000 0,02327359 0,0768343 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02327359 0,07673061 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02327359 0,0766272 ! metaphase plate congression GO:0051310 7 5 0,000 0,02327359 0,07652407 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02327359 0,07642122 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02327359 0,07631864 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02327359 0,07621633 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02327359 0,0761143 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02327359 0,07601255 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02327359 0,07591106 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02327359 0,07580985 ! B cell homeostasis GO:0001782 13 5 0,000 0,02327359 0,0757089 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02327359 0,07560823 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02327359 0,07550782 ! metaphase GO:0051323 11 5 0,000 0,02327359 0,07540767 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02327359 0,0753078 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02327359 0,07520818 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02327359 0,07510883 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02327359 0,07500974 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02327359 0,07491092 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02327359 0,07481235 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02327359 0,07471404 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02327359 0,07461599 ! response to redox state GO:0051775 6 5 0,000 0,02327359 0,0745182 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02327359 0,07442066 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02327359 0,07432338 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02327359 0,07422635 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02327359 0,07412958 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02327359 0,07403305 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02327359 0,07393678 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02327359 0,07384076 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02327359 0,07374499 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02327359 0,07364946 ! striatum development GO:0021756 14 5 0,000 0,02327359 0,07355419 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02327359 0,07345915 ! glial cell migration GO:0008347 10 5 0,000 0,02327359 0,07336437 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02327359 0,07326983 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02327359 0,07317553 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02327359 0,07308147 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02327359 0,07298766 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02327359 0,07289408 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02327359 0,07280075 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02327359 0,07270765 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02327359 0,0726148 ! neuroprotection GO:0043526 8 5 0,000 0,02327359 0,07252218 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02327359 0,07242979 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02327359 0,07233764 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02327359 0,07224572 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02327359 0,07215404 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02327359 0,07206259 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02327359 0,07197137 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02327359 0,07188039 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02327359 0,07178963 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02327359 0,0716991 ! spindle assembly GO:0051225 6 5 0,000 0,02327359 0,0716088 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02327359 0,07151872 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02327359 0,07142888 ! protein palmitoylation GO:0018345 12 5 0,000 0,02327359 0,07133925 ! drug metabolic process GO:0017144 7 5 0,000 0,02327359 0,07124986 ! organ regeneration GO:0031100 7 5 0,000 0,02327359 0,07116068 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02327359 0,07107173 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02327359 0,070983 ! viral infectious cycle GO:0019058 104 51 1,000 0,02406797 0,07331429 ! detection of abiotic stimulus GO:0009582 80 51 1,000 0,02406797 0,07322299 ! histone modification GO:0016570 104 52 1,000 0,02495464 0,07582611 ! positive regulation of growth GO:0045927 96 53 1,000 0,02585449 0,07846277 ! cartilage development GO:0051216 99 53 1,000 0,02585449 0,07836542 ! synapse organization GO:0050808 102 53 1,000 0,02585449 0,07826831 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,02676739 0,08093159 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 1,000 0,02676739 0,08083155 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 1,000 0,02676739 0,08073176 ! covalent chromatin modification GO:0016569 115 54 1,000 0,02676739 0,08063221 ! regulation of cell shape GO:0008360 142 54 1,000 0,02676739 0,08053291 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,02769318 0,08321579 ! cell recognition GO:0008037 98 55 1,000 0,02769318 0,08311356 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,02769318 0,08301158 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02786329 0,08341914 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02786329 0,08331704 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02786329 0,08321518 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02786329 0,08311358 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02786329 0,08301222 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02786329 0,08291111 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02786329 0,08281024 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02786329 0,08270962 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02786329 0,08260925 ! response to oxygen radical GO:0000305 11 6 0,000 0,02786329 0,08250912 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02786329 0,08240923 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02786329 0,08230958 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02786329 0,08221017 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02786329 0,082111 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02786329 0,08201207 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02786329 0,08191338 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02786329 0,08181493 ! forebrain regionalization GO:0021871 9 6 0,000 0,02786329 0,08171671 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02786329 0,08161873 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02786329 0,08152098 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02786329 0,08142347 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02786329 0,08132619 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02786329 0,08122914 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02786329 0,08113232 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02786329 0,08103574 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02786329 0,08093938 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02786329 0,08084325 ! malate metabolic process GO:0006108 13 6 0,000 0,02786329 0,08074735 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02786329 0,08065168 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02786329 0,08055624 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02786329 0,08046102 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02786329 0,08036602 ! protein refolding GO:0042026 15 6 0,000 0,02786329 0,08027125 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02786329 0,0801767 ! opsonization GO:0008228 8 6 0,000 0,02786329 0,08008238 ! mating behavior GO:0007617 7 6 0,000 0,02786329 0,07998827 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02786329 0,07989439 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02786329 0,07980073 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02786329 0,07970728 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02786329 0,07961406 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02786329 0,07952105 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02786329 0,07942826 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02786329 0,07933569 ! toxin metabolic process GO:0009404 11 6 0,000 0,02786329 0,07924333 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02786329 0,07915119 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02786329 0,07905926 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02786329 0,07896754 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02786329 0,07887604 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02786329 0,07878475 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02786329 0,07869366 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02786329 0,07860279 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02786329 0,07851213 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02786329 0,07842168 ! protein lipoylation GO:0009249 10 6 0,000 0,02786329 0,07833144 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02786329 0,0782414 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02786329 0,07815157 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02786329 0,07806195 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02786329 0,07797253 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02786329 0,07788332 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02786329 0,07779431 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! response to pH GO:0009268 10 6 0,000 0,02786329 0,0777055 ! hyperosmotic response GO:0006972 10 6 0,000 0,02786329 0,0776169 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02786329 0,0775285 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02786329 0,0774403 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02786329 0,0773523 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02786329 0,07726449 ! urea metabolic process GO:0019627 7 6 0,000 0,02786329 0,07717689 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02786329 0,07708949 ! neutrophil activation GO:0042119 7 6 0,000 0,02786329 0,07700229 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02786329 0,07691528 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02786329 0,07682847 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02786329 0,07674185 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02786329 0,07665543 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02786329 0,0765692 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02786329 0,07648317 ! neuron apoptosis GO:0051402 15 6 0,000 0,02786329 0,07639733 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02786329 0,07631168 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02786329 0,07622623 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02786329 0,07614096 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02786329 0,07605589 ! carnitine transport GO:0015879 10 6 0,000 0,02786329 0,075971 GO:0015838|betaine transport, ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02786329 0,07588631 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02786329 0,0758018 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02786329 0,07571749 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02786329 0,07563336 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02786329 0,07554941 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02786329 0,07546565 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02786329 0,07538208 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02786329 0,07529869 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,02786329 0,07521549 ! response to UV-C GO:0010225 14 6 0,000 0,02786329 0,07513247 ! astrocyte development GO:0014002 16 6 0,000 0,02786329 0,07504964 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02786329 0,07496698 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02786329 0,07488451 ! interaction with symbiont GO:0051702 14 6 0,000 0,02786329 0,07480222 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02786329 0,07472011 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02786329 0,07463818 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02786329 0,07455643 ! response to copper ion GO:0046688 10 6 0,000 0,02786329 0,07447486 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02786329 0,07439346 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02786329 0,07431225 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02786329 0,07423121 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02786329 0,07415035 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02786329 0,07406966 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02786329 0,07398915 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02786329 0,07390882 ! hair follicle maturation GO:0048820 8 6 0,000 0,02786329 0,07382866 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02786329 0,07374867 ! Schwann cell development GO:0014044 15 6 0,000 0,02786329 0,07366885 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02786329 0,07358921 ! response to pheromone GO:0019236 6 6 0,000 0,02786329 0,07350974 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02786329 0,07343044 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02786329 0,07335131 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02786329 0,07327236 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02786329 0,07319357 ! subpallium development GO:0021544 15 6 0,000 0,02786329 0,07311495 ! neural tube patterning GO:0021532 8 6 0,000 0,02786329 0,0730365 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02786329 0,07295822 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02786329 0,07288011 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02786329 0,07280216 ! G2 phase GO:0051319 16 6 0,000 0,02786329 0,07272438 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02786329 0,07264677 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02786329 0,07256932 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02786329 0,07249203 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02786329 0,07241491 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02786329 0,07233796 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02786329 0,07226117 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02786329 0,07218454 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02786329 0,07210807 ! receptor internalization GO:0031623 11 6 0,000 0,02786329 0,07203177 ! plasminogen activation GO:0031639 9 6 0,000 0,02786329 0,07195562 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02786329 0,07187964 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 16 6 0,000 0,02786329 0,07180382 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,02786329 0,07172816 ! protein destabilization GO:0031648 9 6 0,000 0,02786329 0,07165265 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02786329 0,07157731 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02786329 0,07150212 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02786329 0,07142709 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02786329 0,07135222 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02786329 0,07127751 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02786329 0,07120295 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02786329 0,07112855 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02786329 0,0710543 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02786329 0,07098021 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02786329 0,07090627 ! neural plate development GO:0001840 9 6 0,000 0,02786329 0,07083249 ! catecholamine transport GO:0051937 9 6 0,000 0,02786329 0,07075886 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02786329 0,07068538 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02786329 0,07061205 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02786329 0,07053888 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02786329 0,07046586 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02786329 0,07039299 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02786329 0,07032027 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02786329 0,0702477 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02786329 0,07017528 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02786329 0,07010301 GO:0055081|anion homeostasis, ! skeletal muscle fiber development GO:0048741 130 56 1,000 0,02863173 0,07196226 ! glucose catabolic process GO:0006007 88 56 1,000 0,02863173 0,07188831 ! regulation of protein catabolic process GO:0042176 126 56 1,000 0,02863173 0,0718145 ! regulation of DNA replication GO:0006275 105 56 1,000 0,02863173 0,07174084 ! muscle fiber development GO:0048747 131 57 1,000 0,02958291 0,0740482 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,02958291 0,07397241 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,03054656 0,07630394 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,03054656 0,076226 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,03054656 0,07614822 ! tRNA transcription GO:0009304 17 7 0,000 0,03243155 0,08076481 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,03243155 0,08068257 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,03243155 0,08060049 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03243155 0,08051858 ! regulation of helicase activity GO:0051095 16 7 0,000 0,03243155 0,08043683 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,03243155 0,08035525 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,03243155 0,08027384 ! sleep GO:0030431 16 7 0,000 0,03243155 0,08019259 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03243155 0,08011151 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,03243155 0,08003059 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03243155 0,07994983 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,03243155 0,07986923 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03243155 0,0797888 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03243155 0,07970853 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,03243155 0,07962842 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03243155 0,07954847 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,03243155 0,07946869 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,03243155 0,07938906 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03243155 0,07930959 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,03243155 0,07923028 ! glycolipid transport GO:0046836 11 7 0,000 0,03243155 0,07915113 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03243155 0,07907214 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,03243155 0,0789933 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03243155 0,07891462 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03243155 0,0788361 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,03243155 0,07875773 ! pericardium development GO:0060039 16 7 0,000 0,03243155 0,07867952 ! fibril organization GO:0043206 17 7 0,000 0,03243155 0,07860147 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,03243155 0,07852357 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03243155 0,07844582 ! lipoprotein transport GO:0042953 14 7 0,000 0,03243155 0,07836823 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,03243155 0,07829079 ! rhythmic behavior GO:0007622 17 7 0,000 0,03243155 0,0782135 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,03243155 0,07813637 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,03243155 0,07805939 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,03243155 0,07798256 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,03243155 0,07790588 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03243155 0,07782935 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,03243155 0,07775297 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03243155 0,07767674 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,03243155 0,07760067 ! mechanosensory behavior GO:0007638 16 7 0,000 0,03243155 0,07752474 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,03243155 0,07744895 ! positive regulation of heart rate GO:0010460 11 7 0,000 0,03243155 0,07737332 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,03243155 0,07729783 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03243155 0,07722249 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03243155 0,0771473 ! spinal cord patterning GO:0021511 14 7 0,000 0,03243155 0,07707226 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,03243155 0,07699736 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,03243155 0,0769226 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03243155 0,07684799 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,03243155 0,07677353 ! adrenal gland development GO:0030325 17 7 0,000 0,03243155 0,07669921 ! cysteine metabolic process GO:0006534 13 7 0,000 0,03243155 0,07662503 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,03243155 0,07655099 ! ovulation GO:0030728 10 7 0,000 0,03243155 0,0764771 ! adenohypophysis development GO:0021984 11 7 0,000 0,03243155 0,07640336 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,03243155 0,07632975 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,03243155 0,07625628 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,03243155 0,07618296 ! microtubule nucleation GO:0007020 21 7 0,000 0,03243155 0,07610978 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03243155 0,07603674 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,03243155 0,07596383 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03243155 0,07589107 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,03243155 0,07581845 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,03243155 0,07574597 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03243155 0,07567362 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,03243155 0,07560141 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,03243155 0,07552934 ! galactose metabolic process GO:0006012 13 7 0,000 0,03243155 0,07545741 ! vesicle fusion GO:0006906 20 7 0,000 0,03243155 0,07538561 ! response to dietary excess GO:0002021 8 7 0,000 0,03243155 0,07531395 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03243155 0,07524243 ! intracellular pH reduction GO:0051452 13 7 0,000 0,03243155 0,07517104 GO:0045851|pH reduction, ! melanosome organization GO:0032438 10 7 0,000 0,03243155 0,07509979 ! organ growth GO:0035265 15 7 0,000 0,03243155 0,07502867 ! nucleoside transport GO:0015858 11 7 0,000 0,03243155 0,07495769 ! nucleoside salvage GO:0043174 11 7 0,000 0,03243155 0,07488684 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,03243155 0,07481613 ! male sex determination GO:0030238 15 7 0,000 0,03243155 0,07474555 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,03243155 0,0746751 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,03243155 0,07460478 ! parturition GO:0007567 16 7 0,000 0,03243155 0,0745346 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,03243155 0,07446455 ! rRNA modification GO:0000154 14 7 0,000 0,03243155 0,07439463 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,03243155 0,07432484 ! spindle checkpoint GO:0031577 16 7 0,000 0,03243155 0,07425518 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,03243155 0,07418566 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,03243155 0,07411626 ! monocyte differentiation GO:0030224 16 7 0,000 0,03243155 0,07404699 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,03243155 0,07397785 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03243155 0,07390884 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,03243155 0,07383996 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,03243155 0,07377121 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,03243155 0,07370259 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03243155 0,07363409 ! fibrinolysis GO:0042730 11 7 0,000 0,03243155 0,07356572 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,03243155 0,07349748 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,03243155 0,07342936 ! eating behavior GO:0042755 8 7 0,000 0,03243155 0,07336137 ! B cell lineage commitment GO:0002326 21 7 0,000 0,03243155 0,07329351 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03243155 0,07322577 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,03243155 0,07315815 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,03243155 0,07309066 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03243155 0,0730233 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,03243155 0,07295606 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03243155 0,07288894 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,03243155 0,07282195 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,03243155 0,07275508 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,03243155 0,07268833 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,03243155 0,0726217 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03243155 0,0725552 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,03243155 0,07248882 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03243155 0,07242256 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03243155 0,07235642 ! histone ubiquitination GO:0016574 9 7 0,000 0,03243155 0,0722904 ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,03243155 0,0722245 ! T cell lineage commitment GO:0002360 16 7 0,000 0,03243155 0,07215872 ! regulation of lipid transport GO:0032368 14 7 0,000 0,03243155 0,07209307 ! membrane to membrane docking GO:0022614 14 7 0,000 0,03243155 0,07202753 ! transcription termination GO:0006353 14 7 0,000 0,03243155 0,07196211 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03243155 0,07189681 ! anaphase GO:0051322 18 7 0,000 0,03243155 0,07183162 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,03243155 0,07176656 ! axonal fasciculation GO:0007413 19 7 0,000 0,03243155 0,07170161 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,03243155 0,07163678 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,03243155 0,07157207 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,03243155 0,07150747 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,03243155 0,07144299 ! diuresis GO:0030146 12 7 0,000 0,03243155 0,07137863 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03243155 0,07131438 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03243155 0,07125025 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03243155 0,07118624 ! antibiotic transport GO:0042891 9 7 0,000 0,03243155 0,07112233 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03243155 0,07105855 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,03243155 0,07099487 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,03243155 0,07093132 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,03243155 0,07086787 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,03243155 0,07080454 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,03243155 0,07074132 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03243155 0,07067822 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03243155 0,07061522 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,03243155 0,07055234 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,03243155 0,07048957 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,03243155 0,07042692 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,03243155 0,07036437 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,03243155 0,07030193 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,03243155 0,07023961 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,03243155 0,0701774 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,03243155 0,07011529 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03243155 0,0700533 ! muscle adaptation GO:0043500 13 7 0,000 0,03243155 0,06999141 ! embryonic heart tube development GO:0035050 14 7 0,000 0,03243155 0,06992964 ! retina homeostasis GO:0001895 12 7 0,000 0,03243155 0,06986797 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,03243155 0,06980641 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,03243155 0,06974496 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,03243155 0,06968362 ! lipid modification GO:0030258 112 60 1,000 0,03251079 0,06979249 ! regulation of endocytosis GO:0030100 104 60 1,000 0,03251079 0,06973121 ! kidney development GO:0001822 133 60 1,000 0,03251079 0,06967004 ! positive regulation of secretion GO:0051047 110 61 1,000 0,03351108 0,07175071 ! camera-type eye development GO:0043010 126 61 1,000 0,03351108 0,07168788 ! negative regulation of response to stimulus GO:0048585 106 61 1,000 0,03351108 0,07162517 ! viral reproductive process GO:0022415 132 62 1,000 0,03452331 0,07372417 ! regulation of mitosis GO:0007088 112 63 1,000 0,03554736 0,07584471 GO:0051783|regulation of nuclear division, ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,03658308 0,07798644 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,03697847 0,0787606 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,03697847 0,07869199 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,03697847 0,07862351 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,03697847 0,07855514 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,03697847 0,07848689 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,03697847 0,07841876 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,03697847 0,07835074 ! male meiosis GO:0007140 9 8 0,000 0,03697847 0,07828285 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,03697847 0,07821507 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,03697847 0,07814741 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,03697847 0,07807987 ! meiotic prophase I GO:0007128 14 8 0,000 0,03697847 0,07801244 ! response to zinc ion GO:0010043 12 8 0,000 0,03697847 0,07794513 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,03697847 0,07787794 ! oligopeptide transport GO:0006857 16 8 0,000 0,03697847 0,07781086 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,03697847 0,0777439 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,03697847 0,07767705 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,03697847 0,07761032 ! signal peptide processing GO:0006465 12 8 0,000 0,03697847 0,0775437 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,03697847 0,07747719 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,03697847 0,0774108 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,03697847 0,07734453 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,03697847 0,07727836 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,03697847 0,07721231 ! estrogen metabolic process GO:0008210 17 8 0,000 0,03697847 0,07714638 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,03697847 0,07708055 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,03697847 0,07701484 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,03697847 0,07694924 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03697847 0,07688375 ! reflex GO:0060004 17 8 0,000 0,03697847 0,07681837 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,03697847 0,07675311 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,03697847 0,07668795 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,03697847 0,07662291 ! pigment granule organization GO:0048753 17 8 0,000 0,03697847 0,07655797 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,03697847 0,07649315 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,03697847 0,07642843 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,03697847 0,07636383 ! astrocyte differentiation GO:0048708 19 8 0,000 0,03697847 0,07629933 ! histidine catabolic process GO:0006548 10 8 0,000 0,03697847 0,07623494 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,03697847 0,07617066 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,03697847 0,07610649 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,03697847 0,07604243 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,03697847 0,07597848 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,03697847 0,07591463 ! melanin metabolic process GO:0006582 17 8 0,000 0,03697847 0,07585089 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,03697847 0,07578725 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,03697847 0,07572373 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,03697847 0,07566031 ! macrophage activation GO:0042116 13 8 0,000 0,03697847 0,07559699 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,03697847 0,07553379 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,03697847 0,07547068 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,03697847 0,07540769 ! purine salvage GO:0043101 12 8 0,000 0,03697847 0,07534479 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,03697847 0,07528201 ! osteoblast development GO:0002076 17 8 0,000 0,03697847 0,07521932 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,03697847 0,07515675 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,03697847 0,07509427 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,03697847 0,0750319 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,03697847 0,07496963 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,03697847 0,07490747 ! response to UV-B GO:0010224 17 8 0,000 0,03697847 0,07484541 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,03697847 0,07478345 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,03697847 0,07472159 ! intermediate filament organization GO:0045109 12 8 0,000 0,03697847 0,07465984 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,03697847 0,07459819 ! cellular extravasation GO:0045123 13 8 0,000 0,03697847 0,07453664 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,03697847 0,07447519 ! response to antibiotic GO:0046677 11 8 0,000 0,03697847 0,07441384 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,03697847 0,0743526 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,03697847 0,07429145 ! DNA topological change GO:0006265 12 8 0,000 0,03697847 0,07423041 ! response to tropane GO:0014073 15 8 0,000 0,03697847 0,07416946 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,03697847 0,07410862 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,03697847 0,07404788 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,03697847 0,07398723 ! mast cell activation GO:0045576 14 8 0,000 0,03697847 0,07392668 ! multicellular organismal aging GO:0010259 20 8 0,000 0,03697847 0,07386624 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,03697847 0,07380589 ! gas homeostasis GO:0033483 14 8 0,000 0,03697847 0,07374564 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,03697847 0,07368549 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,03697847 0,07362543 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,03697847 0,07356548 ! nucleosome disassembly GO:0006337 14 8 0,000 0,03697847 0,07350562 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,03697847 0,07344586 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,03697847 0,0733862 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,03697847 0,07332663 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,03697847 0,07326716 ! intracellular lipid transport GO:0032365 16 8 0,000 0,03697847 0,07320779 ! response to tumor cell GO:0002347 16 8 0,000 0,03697847 0,07314851 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,03697847 0,07308933 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,03697847 0,07303024 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,03697847 0,07297125 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,03697847 0,07291235 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,03697847 0,07285355 ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,03697847 0,07279485 ! hormone catabolic process GO:0042447 17 8 0,000 0,03697847 0,07273624 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,03697847 0,07267772 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,03697847 0,0726193 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,03697847 0,07256097 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,03697847 0,07250273 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,03697847 0,07244459 GO:0010828|positive regulation of glucose transport, ! adult feeding behavior GO:0008343 10 8 0,000 0,03697847 0,07238654 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,03697847 0,07232859 ! ATP catabolic process GO:0006200 11 8 0,000 0,03697847 0,07227073 ! blastocyst growth GO:0001832 19 8 0,000 0,03697847 0,07221296 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,03697847 0,07215528 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,03697847 0,07209769 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,03697847 0,0720402 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,03697847 0,07198279 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,03697847 0,07192548 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,03697847 0,07186826 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,03697847 0,07181113 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,03697847 0,0717541 GO:0006043|glucosamine catabolic process, ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,03697847 0,07169715 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,03697847 0,07164029 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,03697847 0,07158352 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,03697847 0,07152685 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,03697847 0,07147026 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,03697847 0,07141376 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,03697847 0,07135735 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,03697847 0,07130103 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,03763035 0,07250075 GO:0048609|reproductive process in a multicellular organism, ! ear development GO:0043583 114 66 1,000 0,03868904 0,07448173 ! regulation of cytokine biosynthetic process GO:0042035 108 66 1,000 0,03868904 0,07442308 ! gonad development GO:0008406 115 66 1,000 0,03868904 0,07436453 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,03975901 0,07636106 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 1,000 0,03975901 0,07630107 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,04084015 0,07831435 ! hexose catabolic process GO:0019320 113 68 1,000 0,04084015 0,07825292 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,04084015 0,0781916 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 1,000 0,04084015 0,07813037 ! viral reproduction GO:0016032 142 68 1,000 0,04084015 0,07806923 ! regulation of lipase activity GO:0060191 137 68 1,000 0,04084015 0,07800819 ! adaptive immune response GO:0002250 126 68 1,000 0,04084015 0,07794725 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 0,04084015 0,0778864 ! axon extension GO:0048675 16 9 0,000 0,04150415 0,07909099 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,04150415 0,07902934 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,04150415 0,07896779 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,04150415 0,07890634 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04150415 0,07884498 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,04150415 0,07878372 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,04150415 0,07872255 ! reproductive behavior GO:0019098 22 9 0,000 0,04150415 0,07866148 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04150415 0,0786005 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,04150415 0,07853962 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,04150415 0,07847883 ! UTP metabolic process GO:0046051 10 9 0,000 0,04150415 0,07841813 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,04150415 0,07835753 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,04150415 0,07829702 ! artery development GO:0060840 25 9 0,000 0,04150415 0,07823661 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,04150415 0,07817629 ! regulation of glycolysis GO:0006110 20 9 0,000 0,04150415 0,07811606 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,04150415 0,07805592 ! equilibrioception GO:0050957 20 9 0,000 0,04150415 0,07799588 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,04150415 0,07793593 ! chemosensory behavior GO:0007635 21 9 0,000 0,04150415 0,07787607 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,04150415 0,07781631 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04150415 0,07775663 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,04150415 0,07769705 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,04150415 0,07763755 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,04150415 0,07757815 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,04150415 0,07751884 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04150415 0,07745962 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04150415 0,07740049 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,04150415 0,07734145 ! protein targeting to ER GO:0045047 25 9 0,000 0,04150415 0,0772825 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,04150415 0,07722365 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,04150415 0,07716488 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,04150415 0,07710619 ! glycine catabolic process GO:0006546 15 9 0,000 0,04150415 0,0770476 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,04150415 0,0769891 ! endosome organization GO:0007032 20 9 0,000 0,04150415 0,07693069 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04150415 0,07687236 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,04150415 0,07681413 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04150415 0,07675598 ! mannose metabolic process GO:0006013 13 9 0,000 0,04150415 0,07669792 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,04150415 0,07663994 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,04150415 0,07658206 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,04150415 0,07652426 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,04150415 0,07646655 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,04150415 0,07640893 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04150415 0,07635139 ! retinol metabolic process GO:0042572 20 9 0,000 0,04150415 0,07629394 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,04150415 0,07623658 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,04150415 0,0761793 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,04150415 0,07612211 ! oligodendrocyte development GO:0014003 11 9 0,000 0,04150415 0,076065 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04150415 0,07600798 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,04150415 0,07595105 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04150415 0,0758942 ! response to amine stimulus GO:0014075 13 9 0,000 0,04150415 0,07583743 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04150415 0,07578075 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,04150415 0,07572416 ! erythrocyte development GO:0048821 17 9 0,000 0,04150415 0,07566765 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04150415 0,07561122 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,04150415 0,07555488 ! renal water homeostasis GO:0003091 15 9 0,000 0,04150415 0,07549862 ! postreplication repair GO:0006301 25 9 0,000 0,04150415 0,07544244 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,04150415 0,07538635 ! icosanoid secretion GO:0032309 15 9 0,000 0,04150415 0,07533035 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04150415 0,07527442 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,04150415 0,07521858 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,04150415 0,07516282 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,04150415 0,07510715 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04150415 0,07505155 ! sterol catabolic process GO:0016127 14 9 0,000 0,04150415 0,07499604 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04150415 0,07494061 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,04150415 0,07488526 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,04150415 0,07483 ! S phase GO:0051320 10 9 0,000 0,04150415 0,07477481 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,04150415 0,07471971 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,04150415 0,07466469 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,04150415 0,07460975 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,04150415 0,07455489 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04150415 0,07450011 ! purine base metabolic process GO:0006144 25 9 0,000 0,04150415 0,07444541 ! pigment granule transport GO:0051904 17 9 0,000 0,04150415 0,07439079 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,04150415 0,07433625 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,04150415 0,07428179 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,04150415 0,07422741 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,04150415 0,07417311 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,04150415 0,07411889 ! mitochondrion localization GO:0051646 18 9 0,000 0,04150415 0,07406475 ! developmental maturation GO:0021700 128 69 1,000 0,04193231 0,07477419 ! germ cell development GO:0007281 133 70 1,000 0,04303539 0,07668523 ! activation of immune response GO:0002253 120 70 1,000 0,04303539 0,07662934 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,04414924 0,07855543 ! appendage morphogenesis GO:0035107 150 72 1,000 0,04527376 0,08049766 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 1,000 0,04527376 0,08043912 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,04600869 0,08168549 ! regulation of developmental growth GO:0048638 16 10 0,000 0,04600869 0,08162617 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,04600869 0,08156693 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,04600869 0,08150779 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,04600869 0,08144872 ! associative learning GO:0008306 21 10 0,000 0,04600869 0,08138974 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,04600869 0,08133085 ! phosphate transport GO:0006817 24 10 0,000 0,04600869 0,08127204 ! cell volume homeostasis GO:0006884 17 10 0,000 0,04600869 0,08121332 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,04600869 0,08115468 ! CTP metabolic process GO:0046036 11 10 0,000 0,04600869 0,08109613 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,04600869 0,08103766 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,04600869 0,08097928 ! GTP metabolic process GO:0046039 11 10 0,000 0,04600869 0,08092098 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,04600869 0,08086276 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,04600869 0,08080463 ! social behavior GO:0035176 29 10 0,000 0,04600869 0,08074658 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,04600869 0,08068861 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,04600869 0,08063073 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,04600869 0,08057293 ! androgen metabolic process GO:0008209 17 10 0,000 0,04600869 0,08051521 ! phospholipid efflux GO:0033700 19 10 0,000 0,04600869 0,08045758 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,04600869 0,08040003 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,04600869 0,08034256 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,04600869 0,08028517 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,04600869 0,08022786 ! pathogenesis GO:0009405 17 10 0,000 0,04600869 0,08017064 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,04600869 0,0801135 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,04600869 0,08005644 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,04600869 0,07999946 ! endoderm development GO:0007492 18 10 0,000 0,04600869 0,07994256 ! arginine catabolic process GO:0006527 17 10 0,000 0,04600869 0,07988574 ! proline metabolic process GO:0006560 13 10 0,000 0,04600869 0,079829 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,04600869 0,07977235 GO:0005978|glycogen biosynthetic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,04600869 0,07971577 ! V(D)J recombination GO:0033151 34 10 0,000 0,04600869 0,07965927 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,04600869 0,07960286 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,04600869 0,07954652 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,04600869 0,07949027 ! B cell proliferation GO:0042100 19 10 0,000 0,04600869 0,07943409 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,04600869 0,07937799 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,04600869 0,07932197 ! multicellular organism growth GO:0035264 19 10 0,000 0,04600869 0,07926603 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,04600869 0,07921017 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,04600869 0,07915439 ! ruffle organization GO:0031529 17 10 0,000 0,04600869 0,07909869 ! epithelial cell development GO:0002064 21 10 0,000 0,04600869 0,07904306 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,04600869 0,07898752 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,04600869 0,07893205 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,04600869 0,07887666 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,04600869 0,07882134 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,04600869 0,07876611 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,04600869 0,07871095 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,04600869 0,07865587 ! copper ion homeostasis GO:0055070 13 10 0,000 0,04600869 0,07860086 ! protein heterooligomerization GO:0051291 17 10 0,000 0,04600869 0,07854594 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,04600869 0,07849109 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,04600869 0,07843631 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,04600869 0,07838161 ! segment specification GO:0007379 15 10 0,000 0,04600869 0,07832699 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,04600869 0,07827245 ! blastoderm segmentation GO:0007350 19 10 0,000 0,04600869 0,07821798 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,04600869 0,07816359 ! response to dsRNA GO:0043331 23 10 0,000 0,04600869 0,07810927 ! DNA ligation GO:0006266 18 10 0,000 0,04600869 0,07805502 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,04600869 0,07800086 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,04600869 0,07794677 ! melanosome localization GO:0032400 16 10 0,000 0,04600869 0,07789275 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,04600869 0,07783881 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,04600869 0,07778494 ! induction of an organ GO:0001759 17 10 0,000 0,04600869 0,07773114 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,04600869 0,07767743 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,04600869 0,07762378 ! protein sumoylation GO:0016925 17 10 0,000 0,04600869 0,07757021 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,04600869 0,07751671 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,04600869 0,07746329 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04600869 0,07740994 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,04600869 0,07735667 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,04600869 0,07730346 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,04600869 0,07725033 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! midbrain development GO:0030901 14 10 0,000 0,04600869 0,07719728 ! musculoskeletal movement GO:0050881 16 10 0,000 0,04600869 0,07714429 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,04600869 0,07709138 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,04600869 0,07703854 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,04600869 0,07698578 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,04600869 0,07693308 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,04600869 0,07688046 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,04600869 0,07682791 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,04600869 0,07677543 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,04600869 0,07672303 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,04600869 0,07667069 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,04600869 0,07661843 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,04600869 0,07656624 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,04600869 0,07651412 ! cerebellar cortex development GO:0021695 16 10 0,000 0,04600869 0,07646207 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,04600869 0,07641009 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,04600869 0,07635818 ! response to nicotine GO:0035094 20 10 0,000 0,04600869 0,07630634 ! appendage development GO:0048736 151 73 1,000 0,0464088 0,07691771 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 1,000 0,0464088 0,07686556 ! acute inflammatory response GO:0002526 118 74 1,000 0,04755426 0,07870939 ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,04871001 0,08056774 ! leukocyte mediated immunity GO:0002443 136 75 1,000 0,04871001 0,08051323 ! axon guidance GO:0007411 162 75 1,000 0,04871001 0,08045879 ! learning or memory GO:0007611 161 76 1,000 0,04987593 0,08232898 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 1,000 0,04987593 0,08227339 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,05049219 0,08323375 ! respiratory burst GO:0045730 17 11 0,000 0,05049219 0,08317762 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,05049219 0,08312157 ! telencephalon cell migration GO:0022029 23 11 0,000 0,05049219 0,0830656 ! thyroid gland development GO:0030878 26 11 0,000 0,05049219 0,0830097 ! synapsis GO:0007129 14 11 0,000 0,05049219 0,08295388 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,05049219 0,08289813 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,05049219 0,08284246 ! response to pain GO:0048265 27 11 0,000 0,05049219 0,08278686 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,05049219 0,08273133 ! bone resorption GO:0045453 16 11 0,000 0,05049219 0,08267588 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,05049219 0,08262051 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,05049219 0,08256521 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05049219 0,08250998 ! melanocyte differentiation GO:0030318 20 11 0,000 0,05049219 0,08245482 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,05049219 0,08239974 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,05049219 0,08234474 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,05049219 0,0822898 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,05049219 0,08223494 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,05049219 0,08218016 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,05049219 0,08212544 ! UV protection GO:0009650 20 11 0,000 0,05049219 0,0820708 ! adult heart development GO:0007512 16 11 0,000 0,05049219 0,08201623 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,05049219 0,08196174 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05049219 0,08190732 ! macroautophagy GO:0016236 19 11 0,000 0,05049219 0,08185296 ! temperature homeostasis GO:0001659 18 11 0,000 0,05049219 0,08179868 ! behavioral fear response GO:0001662 27 11 0,000 0,05049219 0,08174448 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,05049219 0,08169034 ! negative regulation of ossification GO:0030279 27 11 0,000 0,05049219 0,08163628 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,05049219 0,08158229 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,05049219 0,08152837 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,05049219 0,08147452 ! regulation of organ growth GO:0046620 14 11 0,000 0,05049219 0,08142074 ! pigment granule localization GO:0051875 20 11 0,000 0,05049219 0,08136703 ! vasoconstriction GO:0042310 20 11 0,000 0,05049219 0,08131339 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,05049219 0,08125983 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,05049219 0,08120633 ! embryonic axis specification GO:0000578 19 11 0,000 0,05049219 0,08115291 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,05049219 0,08109955 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05049219 0,08104627 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,05049219 0,08099305 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,05049219 0,08093991 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,05049219 0,08088683 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,05049219 0,08083382 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,05049219 0,08078089 ! prophase GO:0051324 17 11 0,000 0,05049219 0,08072802 ! neuroblast proliferation GO:0007405 25 11 0,000 0,05049219 0,08067522 ! nucleosome positioning GO:0016584 15 11 0,000 0,05049219 0,08062249 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,05049219 0,08056983 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,05049219 0,08051724 ! apical protein localization GO:0045176 18 11 0,000 0,05049219 0,08046472 ! acid secretion GO:0046717 20 11 0,000 0,05049219 0,08041227 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05049219 0,08035988 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,05049219 0,08030756 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,05049219 0,08025531 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,05049219 0,08020313 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,05049219 0,08015102 ! cholesterol efflux GO:0033344 21 11 0,000 0,05049219 0,08009897 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05049219 0,08004699 ! oocyte development GO:0048599 20 11 0,000 0,05049219 0,07999508 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,05049219 0,07994324 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,05049219 0,07989146 ! embryonic gut development GO:0048566 19 11 0,000 0,05049219 0,07983975 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,05049219 0,07978811 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,05049219 0,07973653 ! activation of innate immune response GO:0002218 16 11 0,000 0,05049219 0,07968502 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,05049219 0,07963358 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,05049219 0,0795822 ! lysogeny GO:0030069 22 11 0,000 0,05049219 0,07953089 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,05049219 0,07947965 ! regulation of embryonic development GO:0045995 35 11 0,000 0,05049219 0,07942847 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,05105189 0,08025725 ! cytosolic calcium ion homeostasis GO:0051480 149 77 1,000 0,05105189 0,08020564 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,05105189 0,08015409 ! monosaccharide catabolic process GO:0046365 125 77 1,000 0,05105189 0,08010262 ! regulation of catabolic process GO:0009894 173 77 1,000 0,05105189 0,0800512 ! antigen processing and presentation GO:0019882 117 78 1,000 0,05223779 0,08185819 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,0534335 0,08367823 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,0546389 0,08551111 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,0546389 0,08545636 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,05495474 0,08589535 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,05495474 0,08584043 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,05495474 0,08578558 ! virus-host interaction GO:0019048 30 12 0,000 0,05495474 0,0857308 ! mating GO:0007618 17 12 0,000 0,05495474 0,08567609 ! protein complex disassembly GO:0043241 28 12 0,000 0,05495474 0,08562145 GO:0043624|cellular protein complex disassembly, ! hippocampus development GO:0021766 29 12 0,000 0,05495474 0,08556688 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,05495474 0,08551237 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,05495474 0,08545794 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,05495474 0,08540358 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,05495474 0,08534929 ! drug transport GO:0015893 16 12 0,000 0,05495474 0,08529506 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,05495474 0,08524091 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,05495474 0,08518682 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,05495474 0,0851328 ! polyamine metabolic process GO:0006595 18 12 0,000 0,05495474 0,08507885 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,05495474 0,08502497 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,05495474 0,08497116 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,05495474 0,08491741 ! lipid digestion GO:0044241 21 12 0,000 0,05495474 0,08486373 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,05495474 0,08481012 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05495474 0,08475658 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,05495474 0,08470311 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,05495474 0,0846497 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,05495474 0,08459636 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,05495474 0,08454309 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,05495474 0,08448988 ! snRNA metabolic process GO:0016073 30 12 0,000 0,05495474 0,08443675 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,05495474 0,08438368 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,05495474 0,08433067 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,05495474 0,08427773 ! cranial nerve development GO:0021545 23 12 0,000 0,05495474 0,08422486 ! fucose catabolic process GO:0019317 25 12 0,000 0,05495474 0,08417205 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,05495474 0,08411932 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,05495474 0,08406664 ! autonomic nervous system development GO:0048483 24 12 0,000 0,05495474 0,08401403 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,05495474 0,08396149 ! zymogen activation GO:0031638 18 12 0,000 0,05495474 0,08390902 ! T cell homeostasis GO:0043029 28 12 0,000 0,05495474 0,08385661 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,05495474 0,08380426 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,05495474 0,08375198 ! oocyte differentiation GO:0009994 21 12 0,000 0,05495474 0,08369977 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,05495474 0,08364762 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,05495474 0,08359553 ! defense response to fungus GO:0050832 15 12 0,000 0,05495474 0,08354351 ! developmental induction GO:0031128 22 12 0,000 0,05495474 0,08349156 GO:0045168|cell-cell signaling involved in cell fate specification, ! lamellipodium assembly GO:0030032 24 12 0,000 0,05495474 0,08343967 ! response to cold GO:0009409 17 12 0,000 0,05495474 0,08338784 ! establishment of cell polarity GO:0030010 21 12 0,000 0,05495474 0,08333608 ! regulation of synapse organization GO:0050807 18 12 0,000 0,05495474 0,08328438 ! muscle cell differentiation GO:0042692 178 81 1,000 0,05585388 0,08459457 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,05831213 0,08826303 ! response to drug GO:0042493 149 83 1,000 0,05831213 0,08820838 ! cellular lipid catabolic process GO:0044242 150 83 1,000 0,05831213 0,08815379 ! cGMP metabolic process GO:0046068 18 13 0,000 0,05939644 0,08973748 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,05939644 0,08968202 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,05939644 0,08962662 ! peroxisomal transport GO:0043574 28 13 0,000 0,05939644 0,0895713 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,05939644 0,08951604 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,05939644 0,08946085 ! organelle fusion GO:0048284 36 13 0,000 0,05939644 0,08940573 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,05939644 0,08935068 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,05939644 0,0892957 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,05939644 0,08924078 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,05939644 0,08918593 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,05939644 0,08913115 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,05939644 0,08907643 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,05939644 0,08902178 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,05939644 0,0889672 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,05939644 0,08891269 ! methionine metabolic process GO:0006555 31 13 0,000 0,05939644 0,08885824 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,05939644 0,08880386 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,05939644 0,08874954 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,05939644 0,0886953 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,05939644 0,08864112 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,05939644 0,088587 ! cytokine metabolic process GO:0042107 24 13 0,000 0,05939644 0,08853295 ! asymmetric protein localization GO:0008105 24 13 0,000 0,05939644 0,08847897 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,05939644 0,08842505 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,05939644 0,0883712 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,05939644 0,08831741 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,05939644 0,08826369 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,05939644 0,08821003 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,05939644 0,08815644 ! protein homotetramerization GO:0051289 24 13 0,000 0,05939644 0,08810292 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,05939644 0,08804946 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,05939644 0,08799606 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,05939644 0,08794273 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,05939644 0,08788946 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,05939644 0,08783626 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,05939644 0,08778312 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,05939644 0,08773005 ! histone methylation GO:0016571 29 13 0,000 0,05939644 0,08767704 ! chromatin silencing GO:0006342 29 13 0,000 0,05939644 0,0876241 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,05939644 0,08757122 ! regulation of epidermis development GO:0045682 19 13 0,000 0,05939644 0,0875184 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,05939644 0,08746565 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,05939644 0,08741296 ! spleen development GO:0048536 24 13 0,000 0,05939644 0,08736033 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,05939644 0,08730776 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,05939644 0,08725526 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,05939644 0,08720283 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,05939644 0,08715045 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,05939644 0,08709814 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,05939644 0,08704589 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,05939644 0,08699371 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,05939644 0,08694159 ! insulin secretion GO:0030073 24 13 0,000 0,05939644 0,08688952 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,05939644 0,08683753 ! acrosome reaction GO:0007340 19 13 0,000 0,05939644 0,08678559 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,05939644 0,08673372 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,05939644 0,0866819 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,06080731 0,08868792 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,06206848 0,09047332 ! regulation of lyase activity GO:0051339 169 86 1,000 0,06206848 0,09041937 ! alcohol catabolic process GO:0046164 142 87 1,000 0,06333854 0,09221458 ! nucleosome assembly GO:0006334 126 87 1,000 0,06333854 0,09215965 ! rRNA transcription GO:0009303 28 14 0,000 0,06381739 0,09280112 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,06381739 0,09274592 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,06381739 0,09269078 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,06381739 0,0926357 ! non-recombinational repair GO:0000726 29 14 0,000 0,06381739 0,09258069 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,06381739 0,09252575 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,06381739 0,09247087 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,06381739 0,09241606 ! RNA polyadenylation GO:0043631 32 14 0,000 0,06381739 0,09236131 ! lipid localization GO:0010876 32 14 0,000 0,06381739 0,09230662 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,06381739 0,092252 ! regulated secretory pathway GO:0045055 24 14 0,000 0,06381739 0,09219745 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,06381739 0,09214296 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,06381739 0,09208853 ! arginine metabolic process GO:0006525 21 14 0,000 0,06381739 0,09203417 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,06381739 0,09197987 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,06381739 0,09192564 ! regulation of heart rate GO:0002027 25 14 0,000 0,06381739 0,09187147 ! fear response GO:0042596 34 14 0,000 0,06381739 0,09181737 ! organic alcohol transport GO:0015850 29 14 0,000 0,06381739 0,09176332 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,06381739 0,09170935 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,06381739 0,09165543 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,06381739 0,09160158 ! neutral amino acid transport GO:0015804 28 14 0,000 0,06381739 0,09154779 ! bone mineralization GO:0030282 18 14 0,000 0,06381739 0,09149407 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,06381739 0,0914404 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,06381739 0,0913868 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,06381739 0,09133327 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,06381739 0,09127979 ! regulation of cellular pH GO:0030641 27 14 0,000 0,06381739 0,09122638 ! ribosome assembly GO:0042255 18 14 0,000 0,06381739 0,09117303 ! cerebellum development GO:0021549 23 14 0,000 0,06381739 0,09111975 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,06381739 0,09106652 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,06381739 0,09101336 ! response to gamma radiation GO:0010332 30 14 0,000 0,06381739 0,09096026 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,06381739 0,09090722 ! NADP metabolic process GO:0006739 24 14 0,000 0,06381739 0,09085425 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,06381739 0,09080133 ! oxygen transport GO:0015671 22 14 0,000 0,06381739 0,09074848 ! male genitalia development GO:0030539 26 14 0,000 0,06381739 0,09069569 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,06381739 0,09064296 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,06381739 0,09059029 ! chromatin assembly GO:0031497 128 88 1,000 0,0646174 0,09167265 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,06590493 0,093445 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,06821769 0,0966681 ! lactation GO:0007595 30 15 0,000 0,06821769 0,09661206 ! reproductive cellular process GO:0048610 22 15 0,000 0,06821769 0,09655609 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,06821769 0,09650018 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,06821769 0,09644433 ! superoxide anion generation GO:0042554 22 15 0,000 0,06821769 0,09638855 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,06821769 0,09633284 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,06821769 0,09627719 ! copper ion transport GO:0006825 22 15 0,000 0,06821769 0,0962216 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,06821769 0,09616608 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,06821769 0,09611062 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,06821769 0,09605522 ! sulfate transport GO:0008272 27 15 0,000 0,06821769 0,09599989 ! response to cAMP GO:0051591 25 15 0,000 0,06821769 0,09594462 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,06821769 0,09588942 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,06821769 0,09583428 ! response to hexose stimulus GO:0009746 25 15 0,000 0,06821769 0,0957792 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,06821769 0,09572419 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,06821769 0,09566924 ! vesicle coating GO:0006901 38 15 0,000 0,06821769 0,09561435 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,06821769 0,09555952 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,06821769 0,09550476 ! regulation of exocytosis GO:0017157 26 15 0,000 0,06821769 0,09545006 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,06821769 0,09539543 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,06821769 0,09534085 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,06821769 0,09528634 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,06821769 0,09523189 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,06821769 0,0951775 ! regulation of vasodilation GO:0042312 27 15 0,000 0,06821769 0,09512318 ! histone deacetylation GO:0016575 24 15 0,000 0,06821769 0,09506892 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,06821769 0,09501471 ! water homeostasis GO:0030104 28 15 0,000 0,06821769 0,09496058 ! cofactor transport GO:0051181 30 15 0,000 0,06821769 0,0949065 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,06821769 0,09485248 ! muscle maintenance GO:0046716 26 15 0,000 0,06821769 0,09479853 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,06821769 0,09474463 ! intestinal absorption GO:0050892 31 15 0,000 0,06821769 0,0946908 ! dopamine metabolic process GO:0042417 35 15 0,000 0,06821769 0,09463703 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,06821769 0,09458332 ! heme biosynthetic process GO:0006783 33 15 0,000 0,06821769 0,09452967 ! cell killing GO:0001906 32 15 0,000 0,06821769 0,09447608 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,06821769 0,09442255 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,06821769 0,09436909 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,06821769 0,09431568 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,06821769 0,09426234 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,06821769 0,09420905 ! actin filament polymerization GO:0030041 27 15 0,000 0,06821769 0,09415582 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,06821769 0,09410266 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,0685056 0,09444649 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 1,000 0,0685056 0,09439322 ! protein-DNA complex assembly GO:0065004 134 92 1,000 0,06981852 0,09614806 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 0,0711397 0,09791227 GO:0010498|proteasomal protein catabolic process, ! female pregnancy GO:0007565 166 94 1,000 0,07246902 0,0996857 ! regulation of membrane potential GO:0042391 179 94 1,000 0,07246902 0,0996296 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,07259742 0,09975 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,07259742 0,09969393 ! positive regulation of cell size GO:0045793 29 16 0,000 0,07259742 0,09963792 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,07259742 0,09958198 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,07259742 0,0995261 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,07259742 0,09947028 ! bone remodeling GO:0046849 28 16 0,000 0,07259742 0,09941452 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,07259742 0,09935883 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,07259742 0,09930319 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07259742 0,09924762 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,07259742 0,09919212 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,07259742 0,09913667 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,07259742 0,09908129 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,07259742 0,09902597 ! startle response GO:0001964 28 16 0,000 0,07259742 0,09897071 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,07259742 0,09891551 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,07259742 0,09886037 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,07259742 0,0988053 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,07259742 0,09875028 ! protein polyubiquitination GO:0000209 41 16 0,000 0,07259742 0,09869533 ! glutamate metabolic process GO:0006536 25 16 0,000 0,07259742 0,09864044 ! pituitary gland development GO:0021983 30 16 0,000 0,07259742 0,09858561 ! response to osmotic stress GO:0006970 27 16 0,000 0,07259742 0,09853084 ! lysosomal transport GO:0007041 31 16 0,000 0,07259742 0,09847613 ! fructose metabolic process GO:0006000 25 16 0,000 0,07259742 0,09842148 ! L-amino acid transport GO:0015807 33 16 0,000 0,07259742 0,09836689 ! stem cell development GO:0048864 46 16 0,000 0,07259742 0,09831236 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,07259742 0,0982579 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,07259742 0,09820349 ! intermediate filament-based process GO:0045103 36 16 0,000 0,07259742 0,09814914 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,07259742 0,09809486 ! axon cargo transport GO:0008088 46 16 0,000 0,07259742 0,09804063 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,07259742 0,09798647 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,07259742 0,09793236 ! DNA replication initiation GO:0006270 28 16 0,000 0,07259742 0,09787831 ! mRNA splice site selection GO:0006376 44 16 0,000 0,07259742 0,09782433 ! tissue regeneration GO:0042246 27 16 0,000 0,07259742 0,0977704 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,07259742 0,09771653 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,07259742 0,09766272 ! biomineral formation GO:0031214 22 16 0,000 0,07259742 0,09760897 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,07259742 0,09755528 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,07259742 0,09750165 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,07259742 0,09744808 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,07259742 0,09739457 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,07259742 0,09734111 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,07259742 0,09728772 ! peptide hormone processing GO:0016486 27 16 0,000 0,07259742 0,09723438 ! regulation of defense response GO:0031347 171 95 1,000 0,07380637 0,09879944 ! nucleosome organization GO:0034728 143 95 1,000 0,07380637 0,09874533 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,07380637 0,09869128 ! metencephalon development GO:0022037 32 17 0,000 0,0769567 0,10284749 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,0769567 0,10279126 ! endothelial cell migration GO:0043542 31 17 0,000 0,0769567 0,10273509 ! gene silencing by RNA GO:0031047 38 17 0,000 0,0769567 0,10267898 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,0769567 0,10262293 ! glial cell development GO:0021782 28 17 0,000 0,0769567 0,10256694 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,0769567 0,10251102 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,0769567 0,10245515 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,0769567 0,10239935 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,0769567 0,10234361 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,0769567 0,10228793 ! myoblast differentiation GO:0045445 50 17 0,000 0,0769567 0,1022323 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,0769567 0,10217674 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,0769567 0,10212124 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,0769567 0,1020658 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,0769567 0,10201042 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,0769567 0,1019551 ! NAD metabolic process GO:0019674 33 17 0,000 0,0769567 0,10189984 ! membrane budding GO:0006900 42 17 0,000 0,0769567 0,10184464 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,0769567 0,1017895 ! regulation of protein binding GO:0043393 33 17 0,000 0,0769567 0,10173442 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,0769567 0,1016794 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,0769567 0,10162444 ! genitalia development GO:0048806 32 17 0,000 0,0769567 0,10156953 ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,0769567 0,10151469 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,0769567 0,10145991 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,0769567 0,10140518 ! steroid catabolic process GO:0006706 34 17 0,000 0,0769567 0,10135052 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,0769567 0,10129591 ! gas transport GO:0015669 26 17 0,000 0,0769567 0,10124136 ! organic cation transport GO:0015695 32 17 0,000 0,0769567 0,10118687 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,0769567 0,10113244 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,07786565 0,10227193 ! positive regulation of immune response GO:0050778 175 100 1,000 0,08061016 0,10581978 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,0812956 0,10666227 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,0812956 0,10660502 ! limbic system development GO:0021761 40 18 0,000 0,0812956 0,10654783 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,0812956 0,1064907 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,0812956 0,10643363 ! adult walking behavior GO:0007628 36 18 0,000 0,0812956 0,10637662 ! patterning of blood vessels GO:0001569 43 18 0,000 0,0812956 0,10631967 ! heart looping GO:0001947 34 18 0,000 0,0812956 0,10626279 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,0812956 0,10620596 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,0812956 0,1061492 ! centrosome cycle GO:0007098 26 18 0,000 0,0812956 0,10609249 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,0812956 0,10603585 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,0812956 0,10597927 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,0812956 0,10592275 ! glycine metabolic process GO:0006544 30 18 0,000 0,0812956 0,10586628 ! glutamine metabolic process GO:0006541 29 18 0,000 0,0812956 0,10580988 ! response to retinoic acid GO:0032526 31 18 0,000 0,0812956 0,10575354 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,0812956 0,10569726 ! DNA integration GO:0015074 32 18 0,000 0,0812956 0,10564104 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,0812956 0,10558487 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,0812956 0,10552877 ! neural crest cell migration GO:0001755 41 18 0,000 0,0812956 0,10547273 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,0812956 0,10541675 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,0812956 0,10536082 GO:0046466|membrane lipid catabolic process, ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,0812956 0,10530496 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,0812956 0,10524915 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,0812956 0,10519341 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,0812956 0,10513772 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,0812956 0,10508209 ! detection of bacterium GO:0016045 22 18 0,000 0,0812956 0,10502652 ! nerve development GO:0021675 34 18 0,000 0,0812956 0,10497101 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,0812956 0,10491556 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,08561423 0,1104306 ! negative regulation of defense response GO:0031348 27 19 0,000 0,08561423 0,11037233 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,08561423 0,11031411 ! neuron maturation GO:0042551 46 19 0,000 0,08561423 0,11025596 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,08561423 0,11019787 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,08561423 0,11013984 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,08561423 0,11008187 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,08561423 0,11002397 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,08561423 0,10996612 ! inositol metabolic process GO:0006020 33 19 0,000 0,08561423 0,10990833 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,08561423 0,10985061 ! memory GO:0007613 34 19 0,000 0,08561423 0,10979295 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,08561423 0,10973534 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,08561423 0,1096778 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,08561423 0,10962032 ! cerebral cortex development GO:0021987 40 19 0,000 0,08561423 0,10956289 ! pigmentation during development GO:0048066 42 19 0,000 0,08561423 0,10950553 ! response to vitamin A GO:0033189 32 19 0,000 0,08561423 0,10944823 ! heme metabolic process GO:0042168 40 19 0,000 0,08561423 0,10939098 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,08561423 0,1093338 ! response to fungus GO:0009620 26 19 0,000 0,08561423 0,10927668 ! heart process GO:0003015 32 19 0,000 0,08561423 0,10921961 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,08561423 0,10916261 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,08561423 0,10910567 ! visual learning GO:0008542 38 19 0,000 0,08561423 0,10904878 ! cellular pigmentation GO:0033059 37 19 0,000 0,08561423 0,10899195 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,08561423 0,10893519 ! vitamin transport GO:0051180 31 19 0,000 0,08561423 0,10887848 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,08561423 0,10882183 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,08561423 0,10876524 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,08561423 0,10870871 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,08561423 0,10865224 ! cilium assembly GO:0042384 38 19 0,000 0,08561423 0,10859583 ! protein secretion GO:0009306 45 20 0,000 0,08991268 0,11398893 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,08991268 0,11392981 ! positive regulation of ossification GO:0045778 50 20 0,000 0,08991268 0,11387075 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,08991268 0,11381175 ! skin development GO:0043588 42 20 0,000 0,08991268 0,11375281 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,08991268 0,11369393 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,08991268 0,11363511 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,08991268 0,11357636 ! response to vitamin GO:0033273 36 20 0,000 0,08991268 0,11351766 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,08991268 0,11345903 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,08991268 0,11340045 GO:0010675|regulation of cellular carbohydrate metabolic process, ! forelimb morphogenesis GO:0035136 35 20 0,000 0,08991268 0,11334194 ! bile acid metabolic process GO:0008206 34 20 0,000 0,08991268 0,11328348 ! retinoid metabolic process GO:0001523 34 20 0,000 0,08991268 0,11322509 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,08991268 0,11316676 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,08991268 0,11310848 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,08991268 0,11305027 GO:0030968|endoplasmic reticulum unfolded protein response, ! body fluid secretion GO:0007589 33 20 0,000 0,08991268 0,11299212 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,08991268 0,11293402 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,08991268 0,11287599 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,08991268 0,11281801 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,08991268 0,1127601 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,08991268 0,11270224 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,08991268 0,11264445 ! cell-cell junction organization GO:0045216 43 20 0,000 0,08991268 0,11258671 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,08991268 0,11252903 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,08991268 0,11247142 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,08991268 0,11241386 ! regulation of glucose import GO:0046324 30 20 0,000 0,08991268 0,11235635 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,08991268 0,11229891 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,08991268 0,11224153 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,08991268 0,11218421 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,09419104 0,11746234 ! cAMP metabolic process GO:0046058 41 21 0,000 0,09419104 0,11740241 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,09419104 0,11734254 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,09419104 0,11728273 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,09419104 0,11722298 ! ovarian follicle development GO:0001541 39 21 0,000 0,09419104 0,1171633 ! smooth muscle contraction GO:0006939 48 21 0,000 0,09419104 0,11710367 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,09419104 0,11704411 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,09419104 0,1169846 ! plasma membrane fusion GO:0045026 33 21 0,000 0,09419104 0,11692516 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,09419104 0,11686578 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,09419104 0,11680645 ! sensory perception of pain GO:0019233 33 21 0,000 0,09419104 0,11674719 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,09419104 0,11668799 ! diencephalon development GO:0021536 36 21 0,000 0,09419104 0,11662885 ! collagen fibril organization GO:0030199 62 21 0,000 0,09419104 0,11656976 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,09419104 0,11651074 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,09419104 0,11645178 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,09419104 0,11639288 ! collagen catabolic process GO:0030574 29 21 0,000 0,09419104 0,11633403 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,09419104 0,11627525 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,09419104 0,11621652 ! sperm-egg recognition GO:0035036 23 21 0,000 0,09419104 0,11615786 ! actin filament-based movement GO:0030048 47 21 0,000 0,09419104 0,11609925 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,09419104 0,1160407 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,09844941 0,12122576 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,09844941 0,12116469 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,09844941 0,12110368 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,09844941 0,12104274 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,09844941 0,12098185 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,09844941 0,12092102 ! microtubule-based transport GO:0010970 59 22 0,000 0,09844941 0,12086026 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,09844941 0,12079956 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,09844941 0,12073891 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,09844941 0,12067833 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,09844941 0,12061781 ! cellular response to starvation GO:0009267 37 22 0,000 0,09844941 0,12055735 ! vacuolar transport GO:0007034 41 22 0,000 0,09844941 0,12049695 ! central nervous system neuron development GO:0021954 47 22 0,000 0,09844941 0,12043661 ! fucose metabolic process GO:0006004 44 22 0,000 0,09844941 0,12037633 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,09844941 0,12031612 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,09844941 0,12025596 ! ureteric bud development GO:0001657 50 22 0,000 0,09844941 0,12019586 ! stem cell differentiation GO:0048863 57 22 0,000 0,09844941 0,12013582 ! cytolysis GO:0019835 27 22 0,000 0,09844941 0,12007584 ! renal system process GO:0003014 42 22 0,000 0,09844941 0,12001593 ! vasodilation GO:0042311 40 22 0,000 0,09844941 0,11995607 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,09844941 0,11989627 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,09844941 0,11983653 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,09844941 0,11977685 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,09844941 0,11971723 ! sarcomere organization GO:0045214 32 22 0,000 0,09844941 0,11965767 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,09844941 0,11959817 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,09844941 0,11953872 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,09844941 0,11947934 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,09844941 0,11942002 ! gut development GO:0048565 44 22 0,000 0,09844941 0,11936075 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,09844941 0,11930154 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,09844941 0,1192424 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,10268788 0,12431442 ! gluconeogenesis GO:0006094 38 23 0,000 0,10268788 0,12425285 ! glycerol metabolic process GO:0006071 40 23 0,000 0,10268788 0,12419134 ! viral genome replication GO:0019079 44 23 0,000 0,10268788 0,12412989 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,10268788 0,1240685 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,10268788 0,12400717 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,10268788 0,1239459 ! regeneration GO:0031099 42 23 0,000 0,10268788 0,12388469 ! axis specification GO:0009798 43 23 0,000 0,10268788 0,12382354 ! visual behavior GO:0007632 46 23 0,000 0,10268788 0,12376246 ! response to ethanol GO:0045471 47 23 0,000 0,10268788 0,12370143 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,10268788 0,12364046 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,10268788 0,12357956 ! peroxisome organization GO:0007031 43 23 0,000 0,10268788 0,12351871 ! lysosome organization GO:0007040 47 23 0,000 0,10268788 0,12345792 ! vesicle targeting GO:0006903 49 23 0,000 0,10268788 0,1233972 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,10268788 0,12333653 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,10268788 0,12327592 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,10268788 0,12321537 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,10268788 0,12315488 ! fatty acid transport GO:0015908 47 23 0,000 0,10268788 0,12309445 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,10268788 0,12303408 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,10268788 0,12297377 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,10268788 0,12291352 ! cell-cell recognition GO:0009988 28 23 0,000 0,10268788 0,12285333 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,10268788 0,1227932 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,10268788 0,12273312 GO:0006099|tricarboxylic acid cycle, ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,10690655 0,12771281 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,10690655 0,12765039 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,10690655 0,12758803 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,10690655 0,12752573 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,10690655 0,12746349 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,10690655 0,12740131 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,10690655 0,1273392 ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,10690655 0,12727714 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,10690655 0,12721514 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,10690655 0,12715321 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,10690655 0,12709133 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,10690655 0,12702952 ! leukotriene metabolic process GO:0006691 47 24 0,000 0,10690655 0,12696776 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,10690655 0,12690607 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,10690655 0,12684443 ! membrane depolarization GO:0051899 45 24 0,000 0,10690655 0,12678286 ! pallium development GO:0021543 56 24 0,000 0,10690655 0,12672134 ! oogenesis GO:0048477 44 24 0,000 0,10690655 0,12665989 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,10690655 0,12659849 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,10690655 0,12653716 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,10690655 0,12647588 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,10690655 0,12641466 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,10690655 0,1263535 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,10690655 0,1262924 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,10690655 0,12623136 ! regulation of amine transport GO:0051952 41 24 0,000 0,10690655 0,12617038 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,11110549 0,13106264 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,11110549 0,13099938 ! phototransduction GO:0007602 37 25 0,000 0,11110549 0,13093619 ! keratinization GO:0031424 37 25 0,000 0,11110549 0,13087306 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,11110549 0,13080999 ! vacuole organization GO:0007033 49 25 0,000 0,11110549 0,13074697 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,11110549 0,13068402 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,11110549 0,13062114 ! chromosome condensation GO:0030261 48 25 0,000 0,11110549 0,13055831 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,11110549 0,13049554 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,11110549 0,13043283 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,11110549 0,13037018 ! liver development GO:0001889 55 25 0,000 0,11110549 0,13030759 ! protein tetramerization GO:0051262 57 25 0,000 0,11110549 0,13024507 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,11528482 0,13507952 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,11528482 0,13501477 ! molting cycle process GO:0022404 52 26 0,000 0,11528482 0,13495007 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,11528482 0,13488544 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,11528482 0,13482087 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,11528482 0,13475637 GO:0051297|centrosome organization, ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,11528482 0,13469192 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,11528482 0,13462754 ! digestive system process GO:0022600 49 26 0,000 0,11528482 0,13456321 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,11528482 0,13449895 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,11528482 0,13443475 ! osteoblast differentiation GO:0001649 63 26 0,000 0,11528482 0,13437061 ! neural crest cell development GO:0014032 59 26 0,000 0,11528482 0,13430654 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,11528482 0,13424252 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,11528482 0,13417856 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,11528482 0,13411467 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,11528482 0,13405084 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,11528482 0,13398706 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,11528482 0,13392335 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,11528482 0,1338597 ! telomere organization GO:0032200 46 26 0,000 0,11528482 0,13379611 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,11528482 0,13373258 ! neural tube closure GO:0001843 58 26 0,000 0,11528482 0,13366911 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,11528482 0,1336057 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,11528482 0,13354235 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,11528482 0,13347906 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,11944461 0,13822983 ! embryonic pattern specification GO:0009880 49 27 0,000 0,11944461 0,13816438 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,11944461 0,13809899 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,11944461 0,13803367 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,11944461 0,1379684 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,11944461 0,1379032 ! iron ion transport GO:0006826 65 27 0,000 0,11944461 0,13783806 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,11944461 0,13777298 ! superoxide metabolic process GO:0006801 41 27 0,000 0,11944461 0,13770796 ! tube lumen formation GO:0035148 59 27 0,000 0,11944461 0,13764301 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,11944461 0,13757811 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,11944461 0,13751328 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,11944461 0,1374485 ! response to starvation GO:0042594 47 27 0,000 0,11944461 0,13738379 ! response to toxin GO:0009636 49 27 0,000 0,11944461 0,13731914 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,11944461 0,13725455 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,11944461 0,13719002 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,12358496 0,14187878 ! vesicle docking GO:0048278 55 28 0,000 0,12358496 0,14181214 ! circadian rhythm GO:0007623 56 28 0,000 0,12358496 0,14174556 ! fat cell differentiation GO:0045444 57 28 0,000 0,12358496 0,14167905 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,12358496 0,14161259 ! sperm motility GO:0030317 37 28 0,000 0,12358496 0,1415462 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,12358496 0,14147987 ! base-excision repair GO:0006284 41 28 0,000 0,12358496 0,1414136 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,12358496 0,1413474 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,12358496 0,14128126 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,12358496 0,14121518 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,12358496 0,14114916 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,12358496 0,1410832 ! glutathione metabolic process GO:0006749 42 28 0,000 0,12358496 0,1410173 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,12358496 0,14095147 ! lipid oxidation GO:0034440 48 28 0,000 0,12358496 0,1408857 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,12358496 0,14081998 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,12358496 0,14075433 ! translational initiation GO:0006413 66 29 0,000 0,12770595 0,14538007 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,12770595 0,14531236 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! autophagy GO:0006914 47 29 0,000 0,12770595 0,14524471 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,12770595 0,14517712 ! primary neural tube formation GO:0014020 61 29 0,000 0,12770595 0,1451096 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,12770595 0,14504214 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,12770595 0,14497474 ! synaptogenesis GO:0007416 46 29 0,000 0,12770595 0,1449074 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,12770595 0,14484013 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,12770595 0,14477292 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,12770595 0,14470577 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,13180769 0,14928427 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,13180769 0,1492151 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,13180769 0,14914598 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,13180769 0,14907693 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,13180769 0,14900795 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,13180769 0,14893903 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,13180769 0,14887017 ! myofibril assembly GO:0030239 50 30 0,000 0,13180769 0,14880138 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,13180769 0,14873265 ! determination of left/right symmetry GO:0007368 53 30 0,000 0,13180769 0,14866398 ! cell fate determination GO:0001709 64 30 0,000 0,13180769 0,14859537 ! phospholipid transport GO:0015914 65 30 0,000 0,13180769 0,14852683 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,13180769 0,14845836 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,13180769 0,14838994 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,13180769 0,14832159 ! tissue homeostasis GO:0001894 50 30 0,000 0,13180769 0,1482533 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 0,000 0,13180769 0,14818508 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,13589025 0,15270464 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,13589025 0,15263443 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,13589025 0,15256428 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,13589025 0,1524942 ! regulation of innate immune response GO:0045088 57 31 0,000 0,13589025 0,15242419 ! ovulation cycle process GO:0022602 55 31 0,000 0,13589025 0,15235423 ! detection of light stimulus GO:0009583 44 31 0,000 0,13589025 0,15228435 ! natural killer cell activation GO:0030101 50 31 0,000 0,13589025 0,15221452 ! cofactor catabolic process GO:0051187 54 31 0,000 0,13589025 0,15214476 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,13589025 0,15207507 ! eye morphogenesis GO:0048592 65 31 0,000 0,13589025 0,15200544 ! response to heat GO:0009408 54 31 0,000 0,13589025 0,15193587 ! collagen metabolic process GO:0032963 49 32 0,000 0,13995373 0,15640757 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,13995373 0,15633606 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,13995373 0,15626461 ! muscle cell development GO:0055001 52 32 0,000 0,13995373 0,15619322 ! mesoderm formation GO:0001707 73 32 0,000 0,13995373 0,1561219 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,13995373 0,15605064 ! ovulation cycle GO:0042698 57 32 0,000 0,13995373 0,15597945 ! BMP signaling pathway GO:0030509 71 32 0,000 0,13995373 0,15590832 ! hindbrain development GO:0030902 65 32 0,000 0,13995373 0,15583726 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,13995373 0,15576627 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,13995373 0,15569534 ! gene silencing GO:0016458 71 32 0,000 0,13995373 0,15562447 ! regulation of pH GO:0006885 56 33 0,000 0,14399821 0,16004897 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,14399821 0,15997619 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,14399821 0,15990347 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,14399821 0,15983082 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,14399821 0,15975823 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,14399821 0,15968572 ! response to ionizing radiation GO:0010212 74 33 0,000 0,14399821 0,15961326 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,14399821 0,15954088 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,14399821 0,15946855 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,14399821 0,1593963 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,14399821 0,15932411 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,14802379 0,16370399 ! glial cell differentiation GO:0010001 67 34 0,000 0,14802379 0,16362992 ! post-embryonic development GO:0009791 76 34 0,000 0,14802379 0,16355591 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,14802379 0,16348197 ! cholesterol transport GO:0030301 62 34 0,000 0,14802379 0,1634081 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,14802379 0,16333429 ! spliceosome assembly GO:0000245 75 34 0,000 0,14802379 0,16326055 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,14802379 0,16318688 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,14802379 0,16311327 ! formation of primary germ layer GO:0001704 76 34 0,000 0,14802379 0,16303973 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,14802379 0,16296625 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,14802379 0,16289285 ! adult locomotory behavior GO:0008344 62 34 0,000 0,14802379 0,1628195 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,15203055 0,1671515 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,15203055 0,16707631 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,15203055 0,16700118 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,15203055 0,16692613 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,15203055 0,16685114 ! membrane docking GO:0022406 69 35 0,000 0,15203055 0,16677622 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,15203055 0,16670136 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,15203055 0,16662657 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,15203055 0,16655185 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,15203055 0,1664772 ! ceramide metabolic process GO:0006672 72 35 0,000 0,15203055 0,16640261 ! telencephalon development GO:0021537 81 35 0,000 0,15203055 0,16632809 ! sterol transport GO:0015918 63 35 0,000 0,15203055 0,16625364 ! vesicle localization GO:0051648 70 35 0,000 0,15203055 0,16617925 ! regulation of muscle development GO:0048634 82 36 0,000 0,15601858 0,17046216 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,15601858 0,17038596 ! positive regulation of cell development GO:0010720 85 36 0,000 0,15601858 0,17030982 ! protein targeting to membrane GO:0006612 75 36 0,000 0,15601858 0,17023376 ! regulation of proteolysis GO:0030162 77 36 0,000 0,15601858 0,17015776 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,15601858 0,17008183 ! cytokine production GO:0001816 68 36 0,000 0,15601858 0,17000597 ! embryonic organ development GO:0048568 67 36 0,000 0,15601858 0,16993018 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,15601858 0,16985445 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,15601858 0,16977879 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,15998796 0,17402074 ! odontogenesis GO:0042476 74 37 0,000 0,15998796 0,1739433 ! actomyosin structure organization GO:0031032 68 37 0,000 0,15998796 0,17386592 ! female gonad development GO:0008585 71 37 0,000 0,15998796 0,17378861 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,15998796 0,17371137 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,16393879 0,17792202 ! organic anion transport GO:0015711 82 38 0,000 0,16393879 0,17784301 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,16393879 0,17776407 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,16393879 0,17768521 ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,16393879 0,17760641 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,16393879 0,17752769 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,16393879 0,17744903 ! spermatid development GO:0007286 69 38 0,000 0,16393879 0,17737044 ! pigment metabolic process GO:0042440 87 38 0,000 0,16393879 0,17729193 ! neural tube formation GO:0001841 79 38 0,000 0,16393879 0,17721348 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,16787114 0,18138399 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,16787114 0,1813038 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,16787114 0,18122369 GO:0042593|glucose homeostasis, ! nucleotide catabolic process GO:0009166 70 39 0,000 0,16787114 0,18114364 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,16787114 0,18106367 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,17178511 0,18520346 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,17178511 0,18512176 ! learning GO:0007612 82 40 0,000 0,17178511 0,18504014 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,17178511 0,18495859 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 75 40 0,000 0,17178511 0,18487711 ! mismatch repair GO:0006298 58 40 0,000 0,17178511 0,1847957 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,17178511 0,18471436 ! mRNA catabolic process GO:0006402 79 41 0,000 0,17568079 0,18882013 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,17568079 0,1887371 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,17568079 0,18865414 ! gliogenesis GO:0042063 91 41 0,000 0,17568079 0,18857125 ! feeding behavior GO:0007631 69 41 0,000 0,17568079 0,18848843 ! mesenchymal cell development GO:0014031 94 41 0,000 0,17568079 0,18840569 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,17568079 0,18832302 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,17568079 0,18824042 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,17568079 0,18815789 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,17568079 0,18807544 ! RNA modification GO:0009451 64 41 0,000 0,17568079 0,18799306 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,17955824 0,19205814 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,17955824 0,19197408 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,17955824 0,19189011 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,17955824 0,1918062 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,18341757 0,19584314 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,18341757 0,19575759 ! regulation of tube size GO:0035150 76 43 0,000 0,18341757 0,1956721 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,18341757 0,19558669 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,18341757 0,19550136 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,18341757 0,1954161 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,18341757 0,19533091 ! ion transmembrane transport GO:0034220 79 43 0,000 0,18341757 0,1952458 ! neuron migration GO:0001764 85 43 0,000 0,18341757 0,19516076 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,18725885 0,19916124 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,18725885 0,19907457 ! striated muscle contraction GO:0006941 85 44 0,000 0,18725885 0,19898798 ! phagocytosis GO:0006909 105 44 0,000 0,18725885 0,19890146 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,18725885 0,19881502 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,19108216 0,20278615 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,19108216 0,2026981 ! B cell differentiation GO:0030183 124 45 0,000 0,19108216 0,20261012 ! female gamete generation GO:0007292 71 45 0,000 0,19108216 0,20252222 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,19108216 0,2024344 ! polyol metabolic process GO:0019751 77 45 0,000 0,19108216 0,20234665 ! developmental growth GO:0048589 88 45 0,000 0,19108216 0,20225898 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,1948876 0,20619767 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,1948876 0,2061084 ! regulation of gene-specific transcription GO:0032583 102 46 0,000 0,1948876 0,20601922 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,1948876 0,20593011 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,1948876 0,20584108 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,1948876 0,20575212 ! neural tube development GO:0021915 91 47 0,000 0,19867525 0,20966031 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,19867525 0,20956979 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,20244518 0,21345428 ! mitochondrial transport GO:0006839 94 48 0,000 0,20244518 0,21336219 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,20244518 0,21327019 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,20244518 0,21317826 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,20619748 0,21703595 ! JNK cascade GO:0007254 106 49 0,000 0,20619748 0,21694248 ! protein homooligomerization GO:0051260 84 49 0,000 0,20619748 0,21684909 ! regulation of ion transport GO:0043269 86 50 0,000 0,20993223 0,22068177 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,20993223 0,22058685 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,20993223 0,22049202 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,20993223 0,22039727 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,21364951 0,22420351 ! peptide metabolic process GO:0006518 80 51 0,000 0,21364951 0,22410724 ! response to temperature stimulus GO:0009266 84 51 0,000 0,21364951 0,22401106 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,21734941 0,22779263 ! Notch signaling pathway GO:0007219 111 52 0,000 0,21734941 0,22769495 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,21734941 0,22759735 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,21734941 0,22749984 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,21734941 0,22740241 ! excretion GO:0007588 87 52 0,000 0,21734941 0,22730506 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,21734941 0,2272078 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,21734941 0,22711062 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,21734941 0,22701352 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,21734941 0,2269165 ! amino acid activation GO:0043038 98 52 0,000 0,21734941 0,22681957 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! inner ear development GO:0048839 89 53 0,000 0,22103201 0,23056413 ! chromatin remodeling GO:0006338 122 53 0,000 0,22103201 0,23046573 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,22103201 0,2303674 ! vesicle organization GO:0016050 127 53 0,000 0,22103201 0,23026917 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,22103201 0,23017101 ! regulation of translational initiation GO:0006446 87 54 0,000 0,22469738 0,23388824 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,22469738 0,23378863 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,22469738 0,2336891 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,22469738 0,23358966 ! membrane fusion GO:0006944 122 54 0,000 0,22469738 0,2334903 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,22469738 0,23339103 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,22469738 0,23329184 ! RNA catabolic process GO:0006401 103 55 0,000 0,2283456 0,23697889 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,2283456 0,23687826 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,2283456 0,23677772 ! cell maturation GO:0048469 107 55 0,000 0,2283456 0,23667726 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,2283456 0,23657689 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,2283456 0,23647661 ! RNA elongation GO:0006354 90 56 0,000 0,23197677 0,24013527 ! chloride transport GO:0006821 102 57 0,000 0,23559094 0,24377326 ! heart morphogenesis GO:0003007 105 57 0,000 0,23559094 0,24367006 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,23559094 0,24356694 ! regulation of actin filament length GO:0030832 118 58 0,000 0,23918821 0,24718139 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,23918821 0,24707687 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,23918821 0,24697244 ! gastrulation GO:0007369 122 58 0,000 0,23918821 0,2468681 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,24633235 0,25413426 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,24633235 0,25402698 ! adult behavior GO:0030534 104 60 0,000 0,24633235 0,2539198 ! regulation of cellular component size GO:0032535 125 61 0,000 0,24987937 0,25746744 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,24987937 0,25735889 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,24987937 0,25725044 ! regulation of heart contraction GO:0008016 123 61 0,000 0,24987937 0,25714208 ! proton transport GO:0015992 117 61 0,000 0,24987937 0,25703381 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,25340979 0,26055561 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,25340979 0,26044599 ! tRNA processing GO:0008033 102 62 0,000 0,25340979 0,26033647 ! mesoderm development GO:0007498 128 63 0,000 0,25692371 0,26383548 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,25692371 0,26372463 ! hydrogen transport GO:0006818 121 64 0,000 0,26042118 0,26720241 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,26042118 0,26709023 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,26390228 0,27054691 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,26390228 0,27043342 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,26390228 0,27032003 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,26390228 0,27020674 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,27081571 0,27716916 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,27081571 0,27705309 ! secondary metabolic process GO:0019748 125 67 0,000 0,27081571 0,27693712 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,27424818 0,28032983 ! extracellular matrix organization GO:0030198 146 68 0,000 0,27424818 0,28021259 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,27766459 0,2835847 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,27766459 0,28346619 ! single fertilization GO:0007338 83 69 0,000 0,27766459 0,28334778 ! cell redox homeostasis GO:0045454 114 70 0,000 0,28106501 0,28669805 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,28106501 0,28657839 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,28444952 0,2899083 ! B cell activation GO:0042113 179 72 0,000 0,2878182 0,29321929 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,2878182 0,29309706 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,2878182 0,29297494 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,2911711 0,29626448 ! amino acid transport GO:0006865 148 74 0,000 0,29450832 0,29953532 ! transition metal ion transport GO:0000041 143 75 0,000 0,29782992 0,30278756 ! rhythmic process GO:0048511 142 75 0,000 0,29782992 0,3026616 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,30113597 0,30589405 ! regulation of blood pressure GO:0008217 134 76 0,000 0,30113597 0,30576691 ! amine catabolic process GO:0009310 136 77 0,000 0,30442655 0,30897967 ! neurotransmitter transport GO:0006836 142 77 0,000 0,30442655 0,30885136 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,30770173 0,31204455 ! fertilization GO:0009566 99 78 0,000 0,30770173 0,31191508 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,31096158 0,31508882 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,31096158 0,31495819 ! protein oligomerization GO:0051259 149 79 0,000 0,31096158 0,31482766 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,31096158 0,31469724 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,31420617 0,31784914 ! protein import into nucleus GO:0006606 174 82 0,000 0,32064986 0,32423328 ! exocytosis GO:0006887 153 83 0,000 0,3238491 0,32733279 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,3238491 0,32719742 ! nuclear import GO:0051170 177 83 0,000 0,3238491 0,32706216 ! inorganic anion transport GO:0015698 156 83 0,000 0,3238491 0,32692701 ! response to nutrient GO:0007584 135 84 0,000 0,32703337 0,33000517 ! digestion GO:0007586 130 84 0,000 0,32703337 0,32986892 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,33020273 0,3329283 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,33020273 0,33279095 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,336497 0,33899471 ! sensory perception of smell GO:0007608 117 88 0,000 0,33962205 0,34200193 ! tube morphogenesis GO:0035239 194 89 0,000 0,34273247 0,34499194 ! cellular defense response GO:0006968 123 89 0,000 0,34273247 0,34484985 ! protein localization in nucleus GO:0034504 192 89 0,000 0,34273247 0,34470788 ! regulation of neurological system process GO:0031644 175 89 0,000 0,34273247 0,34456602 ! response to unfolded protein GO:0006986 139 90 0,000 0,34582833 0,34753542 ! amine transport GO:0015837 181 93 0,000 0,35502921 0,35663501 ! vitamin metabolic process GO:0006766 153 93 0,000 0,35502921 0,35648843 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,35806749 0,35939149 ! sterol metabolic process GO:0016125 166 94 0,000 0,35806749 0,35924389 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,35806749 0,35909642 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,36109154 0,36198057 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,36109154 0,36183209 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,36109154 0,36168374 ! response to protein stimulus GO:0051789 158 96 0,000 0,36410144 0,3645491 ! forebrain development GO:0030900 210 98 0,000 0,370079 0,37038222 ! mRNA transport GO:0051028 185 100 0,000 0,37600071 0,37615469 ! hormone metabolic process GO:0042445 171 100 0,000 0,37600071 0,37600071