pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1234-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 3,000 2,914E-09 6,701E-06 ! BMP signaling pathway GO:0030509 40 28 3,000 8,201E-07 9,431E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 9,46E-07 7,253E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 9,46E-07 5,44E-04 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 3,000 2,9E-06 1,334E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 1,13E-05 4,331E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 1,604E-05 5,271E-03 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 3,000 1,837E-05 5,28E-03 ! cell-matrix adhesion GO:0007160 114 61 3,000 1,962E-05 5,013E-03 ! negative regulation of ligase activity GO:0051352 91 61 3,000 1,962E-05 4,512E-03 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 3,000 1,962E-05 4,102E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 3,000 2,093E-05 4,012E-03 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 3,000 2,526E-05 4,468E-03 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 3,000 2,526E-05 4,149E-03 ! cell-substrate adhesion GO:0031589 121 66 3,000 2,683E-05 4,115E-03 ! positive regulation of ligase activity GO:0051351 99 69 3,000 3,2E-05 4,6E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 3,32E-05 4,491E-03 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 3,000 3,388E-05 4,329E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 3,583E-05 4,337E-03 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 4,219E-05 4,852E-03 ! regulation of ligase activity GO:0051340 114 75 3,000 4,448E-05 4,871E-03 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 3,000 5,732E-05 5,993E-03 GO:0010498|proteasomal protein catabolic process, ! transcription termination GO:0006353 8 5 1,000 6,739E-05 6,739E-03 ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 7,96E-05 7,628E-03 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 9,636E-05 8,865E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,009E-04 8,928E-03 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 1,000 1,009E-04 8,597E-03 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! ER overload response GO:0006983 7 6 1,000 1,009E-04 8,29E-03 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 1,009E-04 8,004E-03 ! interaction with symbiont GO:0051702 8 6 1,000 1,009E-04 7,737E-03 ! midbrain development GO:0030901 6 6 1,000 1,009E-04 7,488E-03 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 1,052E-04 7,561E-03 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,411E-04 9,831E-03 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 1,411E-04 9,542E-03 ! transcription from RNA polymerase I promoter GO:0006360 12 7 1,000 1,411E-04 9,269E-03 ! chromatin remodeling GO:0006338 68 39 2,000 1,458E-04 9,316E-03 ! positive regulation of protein transport GO:0051222 55 40 2,000 1,573E-04 9,781E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 1,822E-04 0,01102497 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 1,878E-04 0,01107286 ! response to insulin stimulus GO:0032868 63 43 2,000 1,955E-04 0,01123854 ! protein complex disassembly GO:0043241 17 9 1,000 2,41E-04 0,01351936 GO:0043624|cellular protein complex disassembly, ! positive regulation of peptide secretion GO:0002793 15 9 1,000 2,41E-04 0,01319747 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 2,41E-04 0,01289055 ! regulation of intracellular transport GO:0032386 78 49 2,000 2,886E-04 0,01508532 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 3,007E-04 0,01537124 ! focal adhesion formation GO:0048041 24 11 1,000 3,67E-04 0,01834786 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 4,516E-04 0,02210083 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 5,187E-04 0,02485292 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 6,041E-04 0,02835576 ! cell killing GO:0001906 20 14 1,000 6,041E-04 0,02778865 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 6,041E-04 0,02724377 ! regulation of caspase activity GO:0043281 97 65 2,000 6,644E-04 0,02938492 ! lipid phosphorylation GO:0046834 23 15 1,000 6,959E-04 0,03019823 ! myoblast differentiation GO:0045445 27 15 1,000 6,959E-04 0,029639 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 6,959E-04 0,02910011 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 7,259E-04 0,02981549 ! complement activation, alternative pathway GO:0006957 16 16 1,000 7,94E-04 0,03203662 ! regulation of peptidase activity GO:0052547 106 72 2,000 8,955E-04 0,03551156 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 8,983E-04 0,03501866 ! cell-substrate junction assembly GO:0007044 39 17 1,000 8,983E-04 0,03443501 ! cellular macromolecular complex disassembly GO:0034623 29 17 1,000 8,983E-04 0,0338705 ! actin filament bundle formation GO:0051017 26 17 1,000 8,983E-04 0,0333242 ! peptidyl-serine modification GO:0018209 27 17 1,000 8,983E-04 0,03279525 ! pancreas development GO:0031016 26 18 1,000 1,009E-03 0,03625738 ! regulation of protein transport GO:0051223 114 76 2,000 1,048E-03 0,03707763 GO:0070201|regulation of establishment of protein localization, ! cytolysis GO:0019835 20 19 1,000 1,126E-03 0,03922923 ! positive regulation of osteoblast differentiation GO:0045669 33 20 1,000 1,249E-03 0,04286561 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 1,378E-03 0,04660295 ! regulation of insulin secretion GO:0050796 26 21 1,000 1,378E-03 0,04592755 ! regulation of protein localization GO:0032880 132 85 2,000 1,448E-03 0,04757988 ! viral genome replication GO:0019079 29 22 1,000 1,513E-03 0,04901507 ! macromolecular complex disassembly GO:0032984 38 22 1,000 1,513E-03 0,0483343 ! embryonic pattern specification GO:0009880 31 23 1,000 1,654E-03 0,05212507 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 1,654E-03 0,05142068 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 1,654E-03 0,05073507 ! negative regulation of DNA replication GO:0008156 35 23 1,000 1,654E-03 0,05006751 ! osteoblast differentiation GO:0001649 40 23 1,000 1,654E-03 0,04941728 ! interaction with host GO:0051701 37 23 1,000 1,654E-03 0,04878372 ! fat cell differentiation GO:0045444 37 24 1,000 1,802E-03 0,05245709 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 1,802E-03 0,05180138 ! cell fate commitment GO:0045165 141 92 2,000 1,818E-03 0,05161263 ! regulation of peptide secretion GO:0002791 34 25 1,000 1,955E-03 0,05484069 ! cell junction assembly GO:0034329 56 28 1,000 2,451E-03 0,06792503 ! complement activation, classical pathway GO:0006958 36 28 1,000 2,451E-03 0,0671164 ! mesoderm formation GO:0001707 46 28 1,000 2,451E-03 0,0663268 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 2,628E-03 0,07029388 ! formation of primary germ layer GO:0001704 48 29 1,000 2,628E-03 0,0694859 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 2,811E-03 0,07348022 ! hindbrain development GO:0030902 45 30 1,000 2,811E-03 0,0726546 ! mammary gland development GO:0030879 57 31 1,000 3E-03 0,07667404 ! mesoderm morphogenesis GO:0048332 49 31 1,000 3E-03 0,07583147 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 3,195E-03 0,07987409 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 3,195E-03 0,07901523 ! cell junction organization GO:0034330 63 33 1,000 3,395E-03 0,08307922 ! carbohydrate homeostasis GO:0033500 39 33 1,000 3,395E-03 0,08220471 GO:0042593|glucose homeostasis, ! androgen receptor signaling pathway GO:0030521 54 33 1,000 3,395E-03 0,08134841 ! glycerol ether metabolic process GO:0006662 44 34 1,000 3,602E-03 0,08539883 ! glycogen metabolic process GO:0005977 48 35 1,000 3,814E-03 0,08950065 ! protein homooligomerization GO:0051260 52 35 1,000 3,814E-03 0,08859661 ! regulation of hormone secretion GO:0046883 48 36 1,000 4,031E-03 0,09271511 ! organic ether metabolic process GO:0018904 46 36 1,000 4,031E-03 0,09179714 ! hormone-mediated signaling GO:0009755 49 36 1,000 4,031E-03 0,09089717 ! glucan metabolic process GO:0044042 49 36 1,000 4,031E-03 0,09001467 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 4,254E-03 0,09408614 GO:0006956|complement activation, ! mesenchymal cell development GO:0014031 64 38 1,000 4,483E-03 0,09820322 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! energy reserve metabolic process GO:0006112 59 41 1,000 5,203E-03 0,1128998 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 5,454E-03 0,11724112 ! cellular component disassembly GO:0022411 64 42 1,000 5,454E-03 0,11615556 ! excretion GO:0007588 63 42 1,000 5,454E-03 0,11508991 ! activation of caspase activity GO:0006919 65 43 1,000 5,711E-03 0,11940739 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 6,24E-03 0,12930038 ! cell redox homeostasis GO:0045454 63 46 1,000 6,513E-03 0,13374755 ! regulation of ossification GO:0030278 71 46 1,000 6,513E-03 0,13256395 ! viral infectious cycle GO:0019058 71 47 1,000 6,791E-03 0,13701257 ! positive regulation of caspase activity GO:0043280 72 48 1,000 7,075E-03 0,1414904 GO:0010952|positive regulation of peptidase activity, ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 7,075E-03 0,14027066 ! gastrulation GO:0007369 73 48 1,000 7,075E-03 0,13907176 ! regulation of DNA replication GO:0006275 75 48 1,000 7,075E-03 0,13789319 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 7,075E-03 0,13673442 GO:0019724|B cell mediated immunity, ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 7,363E-03 0,14112959 ! skeletal muscle fiber development GO:0048741 73 50 1,000 7,657E-03 0,14555233 ! lipid modification GO:0030258 73 50 1,000 7,657E-03 0,14435928 ! positive regulation of secretion GO:0051047 71 51 1,000 7,957E-03 0,14878188 ! muscle fiber development GO:0048747 74 51 1,000 7,957E-03 0,14758203 ! positive regulation of cell migration GO:0030335 92 51 1,000 7,957E-03 0,14640137 ! negative regulation of cell motion GO:0051271 104 51 1,000 7,957E-03 0,14523946 ! regulation of bone remodeling GO:0046850 90 53 1,000 8,571E-03 0,15521867 ! regulation of mitosis GO:0007088 84 54 1,000 8,886E-03 0,15966328 GO:0051783|regulation of nuclear division, ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 8,886E-03 0,15842558 ! regulation of tissue remodeling GO:0034103 91 54 1,000 8,886E-03 0,15720692 ! mesoderm development GO:0007498 76 55 1,000 9,206E-03 0,16162464 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 9,531E-03 0,16606434 ! positive regulation of cell motion GO:0051272 99 56 1,000 9,531E-03 0,16481574 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 9,861E-03 0,16925246 ! negative regulation of kinase activity GO:0033673 100 58 1,000 0,01019599 0,17370944 ! viral reproductive process GO:0022415 87 58 1,000 0,01019599 0,17243216 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,01019599 0,17117353 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,01019599 0,16993315 ! actin filament organization GO:0007015 95 59 1,000 0,0105362 0,17434002 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,01088141 0,17876595 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,01088141 0,1774981 ! negative regulation of transferase activity GO:0051348 105 61 1,000 0,01123157 0,18191986 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,01158668 0,18635918 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,0119467 0,19081527 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,0119467 0,1894993 ! viral reproduction GO:0016032 92 63 1,000 0,0119467 0,18820136 ! adaptive immune response GO:0002250 94 64 1,000 0,01231159 0,19263037 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! activation of immune response GO:0002253 83 65 1,000 0,01268135 0,19707498 ! protein oligomerization GO:0051259 100 65 1,000 0,01268135 0,19575233 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01308882 0,20069531 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01308882 0,1993662 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01308882 0,19805458 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01308882 0,19676011 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01308882 0,19548245 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01308882 0,19422127 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01308882 0,19297626 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01308882 0,19174711 ! sleep GO:0030431 11 5 0,000 0,01308882 0,19053352 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01308882 0,1893352 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01308882 0,18815186 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01308882 0,18698321 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01308882 0,18582899 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01308882 0,18468894 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01308882 0,18356279 ! tongue development GO:0043586 6 5 0,000 0,01308882 0,18245028 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01308882 0,18135119 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01308882 0,18026525 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01308882 0,17919224 ! cobalt ion transport GO:0006824 9 5 0,000 0,01308882 0,17813193 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01308882 0,1770841 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01308882 0,17604852 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01308882 0,17502498 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01308882 0,17401328 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01308882 0,1730132 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01308882 0,17202455 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01308882 0,17104714 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01308882 0,17008077 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01308882 0,16912526 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01308882 0,16818043 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01308882 0,16724609 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01308882 0,16632208 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01308882 0,16540822 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01308882 0,16450435 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01308882 0,16361031 ! malate metabolic process GO:0006108 7 5 0,000 0,01308882 0,16272593 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01308882 0,16185106 ! behavioral response to pain GO:0048266 7 5 0,000 0,01308882 0,16098555 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01308882 0,16012924 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01308882 0,15928199 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01308882 0,15844367 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01308882 0,15761412 ! mating behavior GO:0007617 6 5 0,000 0,01308882 0,15679321 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01308882 0,15598081 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01308882 0,15517679 ! rhythmic behavior GO:0007622 12 5 0,000 0,01308882 0,15438101 ! copulation GO:0007620 7 5 0,000 0,01308882 0,15359335 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01308882 0,15281369 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01308882 0,1520419 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01308882 0,15127787 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01308882 0,15052148 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01308882 0,14977262 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01308882 0,14903117 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01308882 0,14829703 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01308882 0,14757008 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01308882 0,14685023 ! response to protozoan GO:0001562 9 5 0,000 0,01308882 0,14613736 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,01308882 0,14543139 ! lymph vessel development GO:0001945 7 5 0,000 0,01308882 0,1447322 ! endochondral ossification GO:0001958 12 5 0,000 0,01308882 0,1440397 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01308882 0,14335379 ! parathyroid gland development GO:0060017 8 5 0,000 0,01308882 0,14267439 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01308882 0,1420014 ! anagen GO:0042640 6 5 0,000 0,01308882 0,14133473 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01308882 0,14067428 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01308882 0,14001999 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01308882 0,13937174 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01308882 0,13872948 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01308882 0,13809311 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01308882 0,13746254 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01308882 0,13683771 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01308882 0,13621854 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01308882 0,13560494 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01308882 0,13499685 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01308882 0,13439418 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01308882 0,13379688 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01308882 0,13320485 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01308882 0,13261805 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01308882 0,13203639 ! ovulation GO:0030728 6 5 0,000 0,01308882 0,13145981 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01308882 0,13088825 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01308882 0,13032163 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01308882 0,1297599 ! response to pH GO:0009268 9 5 0,000 0,01308882 0,12920299 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01308882 0,12865084 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01308882 0,12810339 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01308882 0,12756058 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01308882 0,12702235 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01308882 0,12648864 ! polyol catabolic process GO:0046174 7 5 0,000 0,01308882 0,1259594 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01308882 0,12543457 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01308882 0,1249141 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01308882 0,12439792 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01308882 0,123886 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01308882 0,12337827 ! urea metabolic process GO:0019627 6 5 0,000 0,01308882 0,12287468 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01308882 0,12237519 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01308882 0,12187974 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01308882 0,12138829 ! neutrophil activation GO:0042119 5 5 0,000 0,01308882 0,12090079 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01308882 0,12041719 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01308882 0,11993744 ! response to food GO:0032094 5 5 0,000 0,01308882 0,1194615 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01308882 0,11898932 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01308882 0,11852085 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01308882 0,11805607 ! forebrain neuron development GO:0021884 7 5 0,000 0,01308882 0,11759491 ! melanosome organization GO:0032438 7 5 0,000 0,01308882 0,11713734 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01308882 0,11668332 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01308882 0,11623281 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01308882 0,11578576 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01308882 0,11534213 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01308882 0,1149019 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01308882 0,11446501 ! nucleoside transport GO:0015858 6 5 0,000 0,01308882 0,11403143 ! nucleoside salvage GO:0043174 7 5 0,000 0,01308882 0,11360112 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01308882 0,11317405 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01308882 0,11275018 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01308882 0,11232947 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01308882 0,11191188 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01308882 0,1114974 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01308882 0,11108597 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01308882 0,11067756 ! depyrimidination GO:0045008 8 5 0,000 0,01308882 0,11027215 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01308882 0,1098697 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01308882 0,10947017 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01308882 0,10907354 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01308882 0,10867977 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01308882 0,10828884 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01308882 0,10790071 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01308882 0,10751535 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01308882 0,10713273 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01308882 0,10675283 ! monocyte differentiation GO:0030224 8 5 0,000 0,01308882 0,10637561 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01308882 0,10600105 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01308882 0,10562911 ! centrosome duplication GO:0051298 5 5 0,000 0,01308882 0,10525978 ! response to UV-C GO:0010225 6 5 0,000 0,01308882 0,10489302 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01308882 0,10452881 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01308882 0,10416712 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01308882 0,10380792 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01308882 0,10345119 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01308882 0,10309691 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01308882 0,10274504 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01308882 0,10239557 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01308882 0,10204846 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01308882 0,10170371 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01308882 0,10136127 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01308882 0,10102113 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01308882 0,10068327 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01308882 0,10034766 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01308882 0,10001428 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01308882 0,0996831 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01308882 0,09935412 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01308882 0,09902729 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01308882 0,09870261 ! neural tube patterning GO:0021532 6 5 0,000 0,01308882 0,09838006 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01308882 0,0980596 ! histone demethylation GO:0016577 9 5 0,000 0,01308882 0,09774122 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01308882 0,09742491 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01308882 0,09711064 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01308882 0,09679838 ! enteric nervous system development GO:0048484 8 5 0,000 0,01308882 0,09648813 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01308882 0,09617986 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01308882 0,09587356 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01308882 0,0955692 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01308882 0,09526676 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01308882 0,09496624 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01308882 0,0946676 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,01308882 0,09437084 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01308882 0,09407593 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01308882 0,09378286 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01308882 0,09349161 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01308882 0,09320216 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01308882 0,0929145 ! apical protein localization GO:0045176 6 5 0,000 0,01308882 0,09262861 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01308882 0,09234447 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01308882 0,09206207 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01308882 0,09178139 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01308882 0,09150242 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01308882 0,09122514 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01308882 0,09094954 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01308882 0,09067559 ! glial cell migration GO:0008347 10 5 0,000 0,01308882 0,09040329 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01308882 0,09013263 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01308882 0,08986357 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01308882 0,08959612 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01308882 0,08933026 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01308882 0,08906597 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01308882 0,08880324 ! neural plate development GO:0001840 6 5 0,000 0,01308882 0,08854205 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01308882 0,0882824 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01308882 0,08802426 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01308882 0,08776763 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01308882 0,08751249 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01308882 0,08725883 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01308882 0,08700664 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01308882 0,0867559 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01308882 0,0865066 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01308882 0,08625873 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01308882 0,08601228 ! spindle assembly GO:0051225 5 5 0,000 0,01308882 0,08576723 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01308882 0,08552357 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01308882 0,08528129 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01308882 0,08504039 ! organ regeneration GO:0031100 7 5 0,000 0,01308882 0,08480084 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01308882 0,08456263 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01308882 0,08432576 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01308882 0,08409021 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01308882 0,08385598 GO:0055081|anion homeostasis, ! acute inflammatory response GO:0002526 92 68 1,000 0,01381947 0,08829107 ! humoral immune response GO:0006959 86 70 1,000 0,01460201 0,0930322 ! muscle cell differentiation GO:0042692 104 71 1,000 0,01500034 0,095306 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,01500034 0,09504345 ! tRNA transcription GO:0009304 11 6 0,000 0,01568641 0,0991174 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01568641 0,09884584 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01568641 0,09857577 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01568641 0,09830717 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01568641 0,09804003 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01568641 0,09777434 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01568641 0,09751009 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01568641 0,09724726 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01568641 0,09698584 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01568641 0,09672582 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01568641 0,0964672 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01568641 0,09620995 ! prostate gland development GO:0030850 9 6 0,000 0,01568641 0,09595407 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01568641 0,09569955 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01568641 0,09544638 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01568641 0,09519454 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01568641 0,09494403 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01568641 0,09469483 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01568641 0,09444694 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01568641 0,09420034 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01568641 0,09395503 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01568641 0,09371099 ! neuron adhesion GO:0007158 9 6 0,000 0,01568641 0,09346822 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01568641 0,0932267 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01568641 0,09298642 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01568641 0,09274738 ! signal peptide processing GO:0006465 8 6 0,000 0,01568641 0,09250957 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01568641 0,09227297 ! mRNA stabilization GO:0048255 15 6 0,000 0,01568641 0,09203758 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01568641 0,09180339 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01568641 0,09157039 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01568641 0,09133856 ! opsonization GO:0008228 8 6 0,000 0,01568641 0,09110791 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01568641 0,09087842 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01568641 0,09065008 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01568641 0,09042289 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01568641 0,09019683 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01568641 0,0899719 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01568641 0,08974809 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01568641 0,08952539 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01568641 0,08930379 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01568641 0,08908329 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01568641 0,08886387 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01568641 0,08864553 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01568641 0,08842826 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01568641 0,08821206 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01568641 0,08799691 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01568641 0,0877828 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01568641 0,08756974 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01568641 0,0873577 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01568641 0,0871467 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01568641 0,0869367 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01568641 0,08672772 ! thymic T cell selection GO:0045061 12 6 0,000 0,01568641 0,08651974 ! protein lipoylation GO:0009249 10 6 0,000 0,01568641 0,08631276 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01568641 0,08610676 ! pigment granule organization GO:0048753 11 6 0,000 0,01568641 0,08590174 ! drug transport GO:0015893 6 6 0,000 0,01568641 0,0856977 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01568641 0,08549463 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01568641 0,08529251 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01568641 0,08509135 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01568641 0,08489113 ! histidine metabolic process GO:0006547 6 6 0,000 0,01568641 0,08469186 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01568641 0,08449352 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01568641 0,0842961 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 0,01568641 0,08409961 ! adenohypophysis development GO:0021984 10 6 0,000 0,01568641 0,08390403 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01568641 0,08370936 ! hyperosmotic response GO:0006972 8 6 0,000 0,01568641 0,08351558 ! microtubule nucleation GO:0007020 10 6 0,000 0,01568641 0,08332271 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01568641 0,08313072 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01568641 0,08293961 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01568641 0,08274939 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01568641 0,08256003 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01568641 0,08237153 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01568641 0,0821839 ! response to dietary excess GO:0002021 7 6 0,000 0,01568641 0,08199712 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01568641 0,08181118 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01568641 0,08162609 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01568641 0,08144183 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01568641 0,08125841 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01568641 0,0810758 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01568641 0,08089402 ! neuron apoptosis GO:0051402 8 6 0,000 0,01568641 0,08071305 ! organic alcohol transport GO:0015850 9 6 0,000 0,01568641 0,08053288 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01568641 0,08035352 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01568641 0,08017496 ! male sex determination GO:0030238 9 6 0,000 0,01568641 0,07999719 ! carnitine transport GO:0015879 8 6 0,000 0,01568641 0,0798202 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01568641 0,079644 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01568641 0,07946857 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01568641 0,07929392 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01568641 0,07912003 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01568641 0,0789469 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01568641 0,07877452 ! parturition GO:0007567 12 6 0,000 0,01568641 0,0786029 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01568641 0,07843203 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01568641 0,07826189 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01568641 0,07809249 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01568641 0,07792383 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01568641 0,07775589 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01568641 0,07758867 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01568641 0,07742217 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01568641 0,07725639 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01568641 0,07709131 ! macrophage differentiation GO:0030225 10 6 0,000 0,01568641 0,07692693 ! astrocyte development GO:0014002 14 6 0,000 0,01568641 0,07676326 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01568641 0,07660028 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01568641 0,07643799 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01568641 0,07627639 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01568641 0,07611547 ! eating behavior GO:0042755 6 6 0,000 0,01568641 0,07595523 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01568641 0,07579566 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01568641 0,07563675 ! response to copper ion GO:0046688 9 6 0,000 0,01568641 0,07547852 ! DNA topological change GO:0006265 8 6 0,000 0,01568641 0,07532094 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01568641 0,07516403 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01568641 0,07500776 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01568641 0,07485214 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01568641 0,07469717 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01568641 0,07454283 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01568641 0,07438914 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01568641 0,07423607 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01568641 0,07408364 ! gas homeostasis GO:0033483 11 6 0,000 0,01568641 0,07393183 ! hair follicle maturation GO:0048820 7 6 0,000 0,01568641 0,07378064 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01568641 0,07363007 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01568641 0,07348011 ! Schwann cell development GO:0014044 14 6 0,000 0,01568641 0,07333076 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01568641 0,07318201 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01568641 0,07303387 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01568641 0,07288633 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01568641 0,07273938 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01568641 0,07259302 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01568641 0,07244725 ! histone ubiquitination GO:0016574 7 6 0,000 0,01568641 0,07230207 ! regulation of meiosis GO:0040020 10 6 0,000 0,01568641 0,07215746 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01568641 0,07201344 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01568641 0,07186998 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01568641 0,0717271 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01568641 0,07158479 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01568641 0,07144303 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01568641 0,07130184 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01568641 0,07116121 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01568641 0,07102113 ! receptor internalization GO:0031623 9 6 0,000 0,01568641 0,0708816 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01568641 0,07074261 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01568641 0,07060417 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01568641 0,07046627 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01568641 0,07032891 ! protein deubiquitination GO:0016579 8 6 0,000 0,01568641 0,07019209 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01568641 0,07005579 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01568641 0,06992002 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01568641 0,06978478 ! axonal fasciculation GO:0007413 9 6 0,000 0,01568641 0,06965006 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01568641 0,06951586 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01568641 0,06938218 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01568641 0,06924901 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01568641 0,06911634 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01568641 0,06898419 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01568641 0,06885254 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01568641 0,06872139 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01568641 0,06859075 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01568641 0,06846059 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01568641 0,06833093 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01568641 0,06820176 ! adult feeding behavior GO:0008343 6 6 0,000 0,01568641 0,06807308 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01568641 0,06794488 ! blastocyst growth GO:0001832 15 6 0,000 0,01568641 0,06781717 ! pigment granule transport GO:0051904 12 6 0,000 0,01568641 0,06768993 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01568641 0,06756317 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01568641 0,06743688 ! catecholamine transport GO:0051937 7 6 0,000 0,01568641 0,06731107 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01568641 0,06718572 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01568641 0,06706084 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01568641 0,06693642 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01568641 0,06681247 ! protein prenylation GO:0018342 10 6 0,000 0,01568641 0,06668897 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01568641 0,06656593 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01568641 0,06644334 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,01568641 0,0663212 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,01568641 0,06619951 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01568641 0,06607826 ! blood coagulation GO:0007596 116 75 1,000 0,01664007 0,06996739 GO:0050817|coagulation, ! gland development GO:0048732 148 77 1,000 0,01748743 0,07339616 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,0182773 0,07657155 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,0182773 0,07643233 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,0182773 0,07629362 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,0182773 0,0761554 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,0182773 0,07601769 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,0182773 0,07588048 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0182773 0,07574375 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,0182773 0,07560752 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0182773 0,07547178 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,0182773 0,07533653 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,0182773 0,07520176 ! reproductive behavior GO:0019098 12 7 0,000 0,0182773 0,07506747 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,0182773 0,07493366 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,0182773 0,07480033 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,0182773 0,07466747 ! oligopeptide transport GO:0006857 11 7 0,000 0,0182773 0,07453508 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,0182773 0,07440316 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,0182773 0,0742717 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,0182773 0,07414071 ! RNA methylation GO:0001510 11 7 0,000 0,0182773 0,07401018 ! pericardium development GO:0060039 8 7 0,000 0,0182773 0,07388011 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,0182773 0,0737505 ! fibril organization GO:0043206 13 7 0,000 0,0182773 0,07362134 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,0182773 0,07349263 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,0182773 0,07336437 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,0182773 0,07323656 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,0182773 0,07310919 ! lipoprotein transport GO:0042953 9 7 0,000 0,0182773 0,07298226 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,0182773 0,07285578 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,0182773 0,07272973 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,0182773 0,07260412 ! estrogen metabolic process GO:0008210 14 7 0,000 0,0182773 0,07247894 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,0182773 0,07235419 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,0182773 0,07222987 ! chemosensory behavior GO:0007635 9 7 0,000 0,0182773 0,07210597 ! microtubule bundle formation GO:0001578 8 7 0,000 0,0182773 0,07198251 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,0182773 0,07185946 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,0182773 0,07173683 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,0182773 0,07161462 ! leukocyte degranulation GO:0043299 10 7 0,000 0,0182773 0,07149283 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,0182773 0,07137145 ! reflex GO:0060004 12 7 0,000 0,0182773 0,07125048 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,0182773 0,07112992 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,0182773 0,07100977 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0182773 0,07089002 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,0182773 0,07077068 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,0182773 0,07065174 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0182773 0,07053319 ! spinal cord patterning GO:0021511 7 7 0,000 0,0182773 0,07041505 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,0182773 0,0702973 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,0182773 0,07017994 ! adrenal gland development GO:0030325 17 7 0,000 0,0182773 0,07006297 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,0182773 0,06994639 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,0182773 0,0698302 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,0182773 0,0697144 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,0182773 0,06959898 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,0182773 0,06948394 ! endosome organization GO:0007032 10 7 0,000 0,0182773 0,06936928 ! thyroid hormone generation GO:0006590 11 7 0,000 0,0182773 0,069255 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,0182773 0,06914109 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,0182773 0,06902756 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,0182773 0,0689144 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0182773 0,06880161 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,0182773 0,06868919 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,0182773 0,06857713 ! galactose metabolic process GO:0006012 10 7 0,000 0,0182773 0,06846544 ! vesicle fusion GO:0006906 15 7 0,000 0,0182773 0,06835412 ! intracellular pH reduction GO:0051452 10 7 0,000 0,0182773 0,06824315 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,0182773 0,06813255 ! organ growth GO:0035265 11 7 0,000 0,0182773 0,0680223 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,0182773 0,06791241 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,0182773 0,06780288 ! retinol metabolic process GO:0042572 9 7 0,000 0,0182773 0,06769369 ! behavioral fear response GO:0001662 13 7 0,000 0,0182773 0,06758486 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,0182773 0,06747638 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,0182773 0,06736824 ! rRNA modification GO:0000154 12 7 0,000 0,0182773 0,06726045 ! protein heterooligomerization GO:0051291 10 7 0,000 0,0182773 0,06715301 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,0182773 0,06704591 ! response to UV-B GO:0010224 11 7 0,000 0,0182773 0,06693915 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,0182773 0,06683272 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,0182773 0,06672664 ! intermediate filament organization GO:0045109 11 7 0,000 0,0182773 0,06662089 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,0182773 0,06651548 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,0182773 0,0664104 ! fibrinolysis GO:0042730 9 7 0,000 0,0182773 0,06630565 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,0182773 0,06620123 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,0182773 0,06609714 ! B cell lineage commitment GO:0002326 17 7 0,000 0,0182773 0,06599338 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,0182773 0,06588994 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,0182773 0,06578683 ! response to tropane GO:0014073 13 7 0,000 0,0182773 0,06568404 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,0182773 0,06558157 ! melanosome localization GO:0032400 10 7 0,000 0,0182773 0,06547941 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,0182773 0,06537758 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,0182773 0,06527606 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,0182773 0,06517486 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,0182773 0,06507397 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,0182773 0,06497339 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,0182773 0,06487312 ! mast cell activation GO:0045576 9 7 0,000 0,0182773 0,06477316 ! multicellular organismal aging GO:0010259 11 7 0,000 0,0182773 0,06467351 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,0182773 0,06457417 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,0182773 0,06447513 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,0182773 0,06437639 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,0182773 0,06427796 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,0182773 0,06417982 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,0182773 0,06408199 ! T cell lineage commitment GO:0002360 12 7 0,000 0,0182773 0,06398445 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,0182773 0,06388721 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,0182773 0,06379026 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,0182773 0,06369361 ! regulation of lipid transport GO:0032368 13 7 0,000 0,0182773 0,06359725 ! response to tumor cell GO:0002347 12 7 0,000 0,0182773 0,06350118 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,0182773 0,0634054 ! neuroblast proliferation GO:0007405 13 7 0,000 0,0182773 0,06330991 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,0182773 0,06321471 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,0182773 0,06311979 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,0182773 0,06302516 ! diuresis GO:0030146 12 7 0,000 0,0182773 0,06293081 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,0182773 0,06283675 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,0182773 0,06274296 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0182773 0,06264945 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,0182773 0,06255622 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,0182773 0,06246327 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,0182773 0,0623706 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,0182773 0,0622782 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,0182773 0,06218607 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,0182773 0,06209421 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,0182773 0,06200263 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,0182773 0,06191132 ! lymph node development GO:0048535 9 7 0,000 0,0182773 0,06182027 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,0182773 0,06172949 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,0182773 0,06163898 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,0182773 0,06154873 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,0182773 0,06145875 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,0182773 0,06136903 ! ATP catabolic process GO:0006200 10 7 0,000 0,0182773 0,06127957 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,0182773 0,06119037 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,0182773 0,06110143 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,0182773 0,06101275 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,0182773 0,06092432 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,0182773 0,06083616 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,0182773 0,06074824 ! muscle adaptation GO:0043500 12 7 0,000 0,0182773 0,06066058 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,0182773 0,06057317 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,0182773 0,06048602 ! retina homeostasis GO:0001895 9 7 0,000 0,0182773 0,06039911 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,0182773 0,06031246 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,0182773 0,06022605 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,0182773 0,06013989 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,0182773 0,06005398 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,0182773 0,05996831 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,0182773 0,05988288 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,0182773 0,0597977 ! chromatin assembly GO:0031497 102 80 1,000 0,01879227 0,06139519 GO:0006334|nucleosome assembly, ! hemostasis GO:0007599 125 81 1,000 0,01923612 0,06275613 ! mRNA transport GO:0051028 121 81 1,000 0,01923612 0,06266724 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,01923612 0,0625786 ! ossification GO:0001503 134 82 1,000 0,01968438 0,06394644 GO:0060348|bone development, ! protein-DNA complex assembly GO:0065004 107 84 1,000 0,02059404 0,0668072 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02086152 0,06757956 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02086152 0,06748451 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,02086152 0,06738973 ! axon extension GO:0048675 11 8 0,000 0,02086152 0,06729522 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02086152 0,06720097 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02086152 0,06710698 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02086152 0,06701325 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02086152 0,06691979 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02086152 0,06682659 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02086152 0,06673364 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,02086152 0,06664096 ! phosphate transport GO:0006817 10 8 0,000 0,02086152 0,06654853 ! N-glycan processing GO:0006491 12 8 0,000 0,02086152 0,06645636 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02086152 0,06636444 ! UTP metabolic process GO:0046051 8 8 0,000 0,02086152 0,06627278 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02086152 0,06618136 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02086152 0,06609021 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,02086152 0,0659993 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02086152 0,06590864 ! succinate metabolic process GO:0006105 14 8 0,000 0,02086152 0,06581823 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02086152 0,06572807 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02086152 0,06563815 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02086152 0,06554848 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,02086152 0,06545906 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02086152 0,06536988 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02086152 0,06528094 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02086152 0,06519224 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02086152 0,06510378 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02086152 0,06501557 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02086152 0,06492759 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02086152 0,06483985 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02086152 0,06475235 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02086152 0,06466508 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02086152 0,06457805 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,02086152 0,06449125 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02086152 0,06440468 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02086152 0,06431835 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02086152 0,06423225 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02086152 0,06414638 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02086152 0,06406073 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02086152 0,06397532 ! melanin metabolic process GO:0006582 12 8 0,000 0,02086152 0,06389013 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02086152 0,06380517 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02086152 0,06372044 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,02086152 0,06363593 ! macrophage activation GO:0042116 12 8 0,000 0,02086152 0,06355164 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02086152 0,06346758 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02086152 0,06338374 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,02086152 0,06330012 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02086152 0,06321672 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02086152 0,06313354 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02086152 0,06305058 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02086152 0,06296783 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02086152 0,06288531 ! ruffle organization GO:0031529 11 8 0,000 0,02086152 0,062803 ! osteoblast development GO:0002076 13 8 0,000 0,02086152 0,0627209 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02086152 0,06263902 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02086152 0,06255735 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02086152 0,0624759 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02086152 0,06239465 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02086152 0,06231362 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02086152 0,0622328 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02086152 0,06215219 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02086152 0,06207178 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02086152 0,06199159 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02086152 0,0619116 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02086152 0,06183182 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02086152 0,06175224 ! segment specification GO:0007379 10 8 0,000 0,02086152 0,06167287 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02086152 0,0615937 ! cellular extravasation GO:0045123 11 8 0,000 0,02086152 0,06151473 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02086152 0,06143597 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02086152 0,0613574 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02086152 0,06127904 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,02086152 0,06120088 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02086152 0,06112292 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02086152 0,06104515 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,02086152 0,06096758 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02086152 0,06089021 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02086152 0,06081304 ! nucleosome disassembly GO:0006337 12 8 0,000 0,02086152 0,06073606 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02086152 0,06065928 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02086152 0,06058269 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02086152 0,06050629 ! icosanoid secretion GO:0032309 12 8 0,000 0,02086152 0,06043009 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,02086152 0,06035407 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02086152 0,06027825 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02086152 0,06020262 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02086152 0,06012718 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02086152 0,06005193 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02086152 0,05997686 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02086152 0,05990198 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02086152 0,05982729 ! sterol catabolic process GO:0016127 9 8 0,000 0,02086152 0,05975279 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02086152 0,05967847 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02086152 0,05960433 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02086152 0,05953038 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02086152 0,05945662 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02086152 0,05938303 ! prophase GO:0051324 11 8 0,000 0,02086152 0,05930963 ! S phase GO:0051320 8 8 0,000 0,02086152 0,05923641 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02086152 0,05916337 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02086152 0,0590905 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02086152 0,05901782 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02086152 0,05894532 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02086152 0,05887299 ! hormone catabolic process GO:0042447 13 8 0,000 0,02086152 0,05880084 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02086152 0,05872887 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02086152 0,05865708 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02086152 0,05858546 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02086152 0,05851401 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02086152 0,05844274 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02086152 0,05837164 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02086152 0,05830072 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02086152 0,05822996 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02086152 0,05815938 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02086152 0,05808897 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02086152 0,05801873 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02086152 0,05794866 ! regulation of embryonic development GO:0045995 16 8 0,000 0,02086152 0,05787876 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02086152 0,05780902 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02086152 0,05773946 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,02086152 0,05767006 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,02105539 0,05813614 ! transcription initiation GO:0006352 118 85 1,000 0,02105539 0,05806643 ! cell cycle arrest GO:0007050 150 86 1,000 0,02152105 0,05927955 ! nucleosome organization GO:0034728 114 87 1,000 0,021991 0,06050155 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,021991 0,06042927 GO:0060538|skeletal muscle organ development, ! establishment of RNA localization GO:0051236 128 88 1,000 0,02246521 0,06165868 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 1,000 0,02246521 0,06158519 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,02343908 0,06417844 ! regulation of developmental growth GO:0048638 13 9 0,000 0,02343908 0,06410213 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,02343908 0,064026 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02343908 0,06395005 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,02343908 0,06387428 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02343908 0,06379868 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02343908 0,06372327 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,02343908 0,06364804 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02343908 0,06357298 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02343908 0,0634981 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02343908 0,0634234 ! GTP metabolic process GO:0046039 9 9 0,000 0,02343908 0,06334887 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02343908 0,06327452 ! social behavior GO:0035176 14 9 0,000 0,02343908 0,06320034 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02343908 0,06312633 ! artery development GO:0060840 19 9 0,000 0,02343908 0,0630525 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02343908 0,06297884 ! regulation of glycolysis GO:0006110 15 9 0,000 0,02343908 0,06290535 ! response to pain GO:0048265 16 9 0,000 0,02343908 0,06283204 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02343908 0,06275889 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02343908 0,06268592 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02343908 0,06261311 ! lung alveolus development GO:0048286 17 9 0,000 0,02343908 0,06254047 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02343908 0,06246801 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02343908 0,0623957 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02343908 0,06232357 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02343908 0,0622516 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02343908 0,0621798 ! protein targeting to ER GO:0045047 19 9 0,000 0,02343908 0,06210817 ! T cell selection GO:0045058 18 9 0,000 0,02343908 0,0620367 ! endoderm development GO:0007492 12 9 0,000 0,02343908 0,06196539 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02343908 0,06189425 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02343908 0,06182327 ! arginine catabolic process GO:0006527 10 9 0,000 0,02343908 0,06175245 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02343908 0,06168179 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02343908 0,0616113 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02343908 0,06154097 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02343908 0,0614708 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02343908 0,06140078 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02343908 0,06133093 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02343908 0,06126124 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02343908 0,0611917 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02343908 0,06112232 ! mannose metabolic process GO:0006013 9 9 0,000 0,02343908 0,0610531 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02343908 0,06098404 ! receptor clustering GO:0043113 15 9 0,000 0,02343908 0,06091513 ! epithelial cell development GO:0002064 10 9 0,000 0,02343908 0,06084638 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02343908 0,06077778 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02343908 0,06070933 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02343908 0,06064104 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02343908 0,06057291 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02343908 0,06050493 ! motor axon guidance GO:0008045 14 9 0,000 0,02343908 0,06043709 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02343908 0,06036942 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02343908 0,06030189 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02343908 0,06023451 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02343908 0,06016729 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02343908 0,06010021 ! DNA ligation GO:0006266 14 9 0,000 0,02343908 0,06003328 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02343908 0,05996651 ! response to amine stimulus GO:0014075 13 9 0,000 0,02343908 0,05989988 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02343908 0,05983339 ! erythrocyte development GO:0048821 11 9 0,000 0,02343908 0,05976706 ! renal water homeostasis GO:0003091 14 9 0,000 0,02343908 0,05970087 ! postreplication repair GO:0006301 11 9 0,000 0,02343908 0,05963483 ! mRNA cleavage GO:0006379 13 9 0,000 0,02343908 0,05956894 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02343908 0,05950319 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02343908 0,05943758 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02343908 0,05937212 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02343908 0,05930681 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02343908 0,05924164 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02343908 0,05917661 ! acid secretion GO:0046717 14 9 0,000 0,02343908 0,05911172 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02343908 0,05904698 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02343908 0,05898237 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02343908 0,05891791 ! purine base metabolic process GO:0006144 18 9 0,000 0,02343908 0,05885359 ! oocyte differentiation GO:0009994 12 9 0,000 0,02343908 0,05878941 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02343908 0,05872537 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02343908 0,05866147 ! spleen development GO:0048536 15 9 0,000 0,02343908 0,0585977 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02343908 0,05853408 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02343908 0,0584706 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02343908 0,05840725 ! detection of calcium ion GO:0005513 13 9 0,000 0,02343908 0,05834404 ! blastocyst formation GO:0001825 12 9 0,000 0,02343908 0,05828096 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02343908 0,05821802 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02343908 0,05815522 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02343908 0,05809255 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02343908 0,05803002 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02343908 0,05796762 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02343908 0,05790536 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02343908 0,05784323 ! prepulse inhibition GO:0060134 14 9 0,000 0,02343908 0,05778123 ! embryonic placenta development GO:0001892 12 9 0,000 0,02343908 0,05771937 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,02343908 0,05765763 ! insulin secretion GO:0030073 17 9 0,000 0,02343908 0,05759603 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02343908 0,05753457 ! response to nicotine GO:0035094 16 9 0,000 0,02343908 0,05747323 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02343908 0,05741202 ! nucleus localization GO:0051647 15 9 0,000 0,02343908 0,05735095 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02343908 0,05729 ! localization within membrane GO:0051668 15 9 0,000 0,02343908 0,05722918 ! RNA localization GO:0006403 135 91 1,000 0,02391316 0,05832478 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,02440417 0,05945931 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,02440417 0,05939639 ! positive regulation of immune response GO:0050778 121 92 1,000 0,02440417 0,05933361 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,02489932 0,06047354 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,02489932 0,06040975 ! electron transport chain GO:0022900 123 94 1,000 0,02539859 0,06155611 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02601001 0,0629716 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02601001 0,06290538 ! neuron fate specification GO:0048665 11 10 0,000 0,02601001 0,06283931 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02601001 0,06277337 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02601001 0,06270757 ! thyroid gland development GO:0030878 19 10 0,000 0,02601001 0,06264191 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,02601001 0,06257638 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02601001 0,06251099 ! synapsis GO:0007129 13 10 0,000 0,02601001 0,06244574 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02601001 0,06238063 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02601001 0,06231565 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02601001 0,0622508 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02601001 0,06218609 ! sulfate transport GO:0008272 12 10 0,000 0,02601001 0,06212152 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02601001 0,06205707 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02601001 0,06199277 ! androgen metabolic process GO:0008209 13 10 0,000 0,02601001 0,06192859 ! phospholipid efflux GO:0033700 16 10 0,000 0,02601001 0,06186455 ! hippocampus development GO:0021766 19 10 0,000 0,02601001 0,06180064 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02601001 0,06173686 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02601001 0,06167322 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02601001 0,0616097 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02601001 0,06154632 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02601001 0,06148306 ! pathogenesis GO:0009405 13 10 0,000 0,02601001 0,06141994 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02601001 0,06135694 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02601001 0,06129408 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02601001 0,06123134 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02601001 0,06116873 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02601001 0,06110625 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02601001 0,0610439 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02601001 0,06098167 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02601001 0,06091957 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02601001 0,0608576 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02601001 0,06079575 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02601001 0,06073403 ! response to X-ray GO:0010165 16 10 0,000 0,02601001 0,06067243 ! B cell proliferation GO:0042100 14 10 0,000 0,02601001 0,06061096 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02601001 0,06054962 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02601001 0,06048839 ! forebrain cell migration GO:0021885 17 10 0,000 0,02601001 0,06042729 ! lipid digestion GO:0044241 15 10 0,000 0,02601001 0,06036632 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02601001 0,06030546 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02601001 0,06024473 ! UV protection GO:0009650 14 10 0,000 0,02601001 0,06018412 ! entry into host cell GO:0030260 20 10 0,000 0,02601001 0,06012364 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02601001 0,06006327 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02601001 0,06000303 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02601001 0,05994291 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02601001 0,0598829 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02601001 0,05982302 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02601001 0,05976326 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02601001 0,05970361 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02601001 0,05964409 ! regulation of organ growth GO:0046620 11 10 0,000 0,02601001 0,05958468 ! response to dsRNA GO:0043331 18 10 0,000 0,02601001 0,05952539 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02601001 0,05946622 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02601001 0,05940717 ! embryonic axis specification GO:0000578 12 10 0,000 0,02601001 0,05934823 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02601001 0,05928942 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02601001 0,05923071 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02601001 0,05917213 ! cranial nerve development GO:0021545 12 10 0,000 0,02601001 0,05911366 ! fucose catabolic process GO:0019317 16 10 0,000 0,02601001 0,0590553 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02601001 0,05899706 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02601001 0,05893894 ! protein sumoylation GO:0016925 12 10 0,000 0,02601001 0,05888093 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02601001 0,05882303 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02601001 0,05876525 ! zymogen activation GO:0031638 14 10 0,000 0,02601001 0,05870758 ! salivary gland development GO:0007431 22 10 0,000 0,02601001 0,05865002 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02601001 0,05859258 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02601001 0,05853524 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02601001 0,05847803 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02601001 0,05842092 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02601001 0,05836392 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02601001 0,05830704 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02601001 0,05825026 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02601001 0,0581936 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02601001 0,05813705 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,02601001 0,0580806 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02601001 0,05802427 ! detection of bacterium GO:0016045 10 10 0,000 0,02601001 0,05796804 ! embryonic gut development GO:0048566 11 10 0,000 0,02601001 0,05791193 ! activation of innate immune response GO:0002218 10 10 0,000 0,02601001 0,05785592 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02601001 0,05780002 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02601001 0,05774423 ! developmental induction GO:0031128 13 10 0,000 0,02601001 0,05768854 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02601001 0,05763297 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02601001 0,0575775 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02601001 0,05752213 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,02601001 0,05746688 ! in utero embryonic development GO:0001701 147 96 1,000 0,02640937 0,05829324 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,02640937 0,05823735 ! protein maturation GO:0051604 129 96 1,000 0,02640937 0,05818156 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,02847927 0,06268165 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,02847927 0,06262172 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,02847927 0,06256191 ! rRNA transcription GO:0009303 17 11 0,000 0,02857431 0,0627108 ! respiratory burst GO:0045730 14 11 0,000 0,02857431 0,06265102 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,02857431 0,06259135 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,02857431 0,0625318 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,02857431 0,06247236 ! virus-host interaction GO:0019048 17 11 0,000 0,02857431 0,06241303 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,02857431 0,06235382 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,02857431 0,06229471 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,02857431 0,06223572 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,02857431 0,06217684 ! RNA polyadenylation GO:0043631 19 11 0,000 0,02857431 0,06211807 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,02857431 0,06205942 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,02857431 0,06200087 ! mating GO:0007618 14 11 0,000 0,02857431 0,06194243 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,02857431 0,06188411 ! T cell proliferation GO:0042098 20 11 0,000 0,02857431 0,06182589 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,02857431 0,06176778 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,02857431 0,06170979 ! bone resorption GO:0045453 16 11 0,000 0,02857431 0,0616519 ! regulated secretory pathway GO:0045055 14 11 0,000 0,02857431 0,06159412 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,02857431 0,06153644 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,02857431 0,06147888 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,02857431 0,06142142 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,02857431 0,06136407 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,02857431 0,06130683 ! syncytium formation GO:0006949 15 11 0,000 0,02857431 0,06124969 ! plasma membrane organization GO:0007009 18 11 0,000 0,02857431 0,06119266 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,02857431 0,06113574 ! mitotic spindle organization GO:0007052 15 11 0,000 0,02857431 0,06107892 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,02857431 0,06102221 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,02857431 0,0609656 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,02857431 0,0609091 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,02857431 0,06085271 ! adult heart development GO:0007512 11 11 0,000 0,02857431 0,06079641 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,02857431 0,06074022 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,02857431 0,06068414 ! temperature homeostasis GO:0001659 16 11 0,000 0,02857431 0,06062816 ! L-glutamate transport GO:0015813 16 11 0,000 0,02857431 0,06057228 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,02857431 0,0605165 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,02857431 0,06046083 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,02857431 0,06040526 ! stem cell development GO:0048864 29 11 0,000 0,02857431 0,06034979 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,02857431 0,06029442 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,02857431 0,06023916 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,02857431 0,06018399 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,02857431 0,06012893 ! vasoconstriction GO:0042310 15 11 0,000 0,02857431 0,06007397 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,02857431 0,06001911 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,02857431 0,05996434 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,02857431 0,05990968 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,02857431 0,05985512 ! ribosome assembly GO:0042255 13 11 0,000 0,02857431 0,05980066 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,02857431 0,05974629 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,02857431 0,05969203 ! chromatin silencing GO:0006342 19 11 0,000 0,02857431 0,05963786 ! nucleosome positioning GO:0016584 13 11 0,000 0,02857431 0,05958379 ! T cell homeostasis GO:0043029 20 11 0,000 0,02857431 0,05952982 ! regulation of isotype switching GO:0045191 19 11 0,000 0,02857431 0,05947595 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,02857431 0,05942217 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,02857431 0,05936849 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,02857431 0,05931491 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,02857431 0,05926143 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,02857431 0,05920804 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,02857431 0,05915475 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,02857431 0,05910155 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,02857431 0,05904845 ! male genitalia development GO:0030539 13 11 0,000 0,02857431 0,05899544 ! cholesterol efflux GO:0033344 19 11 0,000 0,02857431 0,05894253 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,02857431 0,05888971 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,02857431 0,05883699 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,02857431 0,05878437 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,02857431 0,05873183 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,02857431 0,05867939 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,02857431 0,05862705 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,02857431 0,0585748 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,02857431 0,05852264 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,02857431 0,05847057 ! lysogeny GO:0030069 18 11 0,000 0,02857431 0,0584186 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,02857431 0,05836672 ! acrosome reaction GO:0007340 13 11 0,000 0,02857431 0,05831493 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,02857431 0,05826323 ! lactation GO:0007595 20 12 0,000 0,03113201 0,06342217 ! reproductive cellular process GO:0048610 14 12 0,000 0,03113201 0,06336605 ! tRNA modification GO:0006400 14 12 0,000 0,03113201 0,06331002 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,03113201 0,06325409 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,03113201 0,06319826 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,03113201 0,06314253 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,03113201 0,0630869 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,03113201 0,06303137 ! non-recombinational repair GO:0000726 19 12 0,000 0,03113201 0,06297593 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,03113201 0,06292059 ! peroxisomal transport GO:0043574 21 12 0,000 0,03113201 0,06286535 ! cartilage condensation GO:0001502 18 12 0,000 0,03113201 0,0628102 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,03113201 0,06275516 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,03113201 0,0627002 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,03113201 0,06264535 ! heart looping GO:0001947 15 12 0,000 0,03113201 0,06259059 ! palate development GO:0060021 15 12 0,000 0,03113201 0,06253592 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,03113201 0,06248135 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,03113201 0,06242688 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,03113201 0,0623725 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,03113201 0,06231822 ! arginine metabolic process GO:0006525 13 12 0,000 0,03113201 0,06226403 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,03113201 0,06220993 ! methionine metabolic process GO:0006555 13 12 0,000 0,03113201 0,06215593 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,03113201 0,06210202 ! Golgi organization GO:0007030 18 12 0,000 0,03113201 0,06204821 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,03113201 0,06199449 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,03113201 0,06194086 ! monoamine transport GO:0015844 13 12 0,000 0,03113201 0,06188732 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03113201 0,06183388 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,03113201 0,06178053 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,03113201 0,06172727 ! L-amino acid transport GO:0015807 20 12 0,000 0,03113201 0,0616741 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,03113201 0,06162103 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,03113201 0,06156804 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,03113201 0,06151515 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,03113201 0,06146235 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,03113201 0,06140963 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,03113201 0,06135701 ! cerebellum development GO:0021549 13 12 0,000 0,03113201 0,06130448 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,03113201 0,06125204 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,03113201 0,06119969 ! histone acetylation GO:0016573 23 12 0,000 0,03113201 0,06114742 ! histone methylation GO:0016571 15 12 0,000 0,03113201 0,06109525 ! autonomic nervous system development GO:0048483 23 12 0,000 0,03113201 0,06104316 ! gland morphogenesis GO:0022612 23 12 0,000 0,03113201 0,06099117 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,03113201 0,06093926 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,03113201 0,06088744 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,03113201 0,06083571 ! response to gamma radiation GO:0010332 20 12 0,000 0,03113201 0,06078407 ! regulation of epidermis development GO:0045682 17 12 0,000 0,03113201 0,06073251 ! intestinal absorption GO:0050892 19 12 0,000 0,03113201 0,06068104 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,03113201 0,06062966 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,03113201 0,06057837 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,03113201 0,06052716 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,03113201 0,06047604 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,03113201 0,06042501 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,03113201 0,06037406 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,03113201 0,0603232 ! microspike assembly GO:0030035 23 12 0,000 0,03113201 0,06027242 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,03113201 0,06022173 ! response to cold GO:0009409 14 12 0,000 0,03113201 0,06017112 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,03368313 0,06504718 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,03368313 0,06499261 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,03368313 0,06493813 ! cGMP metabolic process GO:0046068 16 13 0,000 0,03368313 0,06488374 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,03368313 0,06482945 ! water transport GO:0006833 17 13 0,000 0,03368313 0,06477524 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,03368313 0,06472113 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,03368313 0,0646671 ! lipid localization GO:0010876 24 13 0,000 0,03368313 0,06461317 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,03368313 0,06455933 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,03368313 0,06450557 ! organelle fusion GO:0048284 28 13 0,000 0,03368313 0,06445191 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,03368313 0,06439833 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,03368313 0,06434484 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,03368313 0,06429144 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,03368313 0,06423813 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,03368313 0,06418491 ! response to hexose stimulus GO:0009746 19 13 0,000 0,03368313 0,06413178 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,03368313 0,06407873 ! glutamate metabolic process GO:0006536 18 13 0,000 0,03368313 0,06402578 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,03368313 0,06397291 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,03368313 0,06392012 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,03368313 0,06386743 ! NAD metabolic process GO:0019674 21 13 0,000 0,03368313 0,06381482 ! exocrine system development GO:0035272 27 13 0,000 0,03368313 0,0637623 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,03368313 0,06370986 ! bone mineralization GO:0030282 15 13 0,000 0,03368313 0,06365751 ! regulation of exocytosis GO:0017157 17 13 0,000 0,03368313 0,06360525 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,03368313 0,06355307 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,03368313 0,06350098 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,03368313 0,06344897 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,03368313 0,06339705 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,03368313 0,06334521 ! genitalia development GO:0048806 15 13 0,000 0,03368313 0,06329346 ! regulation of cellular pH GO:0030641 20 13 0,000 0,03368313 0,06324179 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,03368313 0,0631902 ! cellular pigmentation GO:0033059 24 13 0,000 0,03368313 0,0631387 ! tissue regeneration GO:0042246 21 13 0,000 0,03368313 0,06308729 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,03368313 0,06303596 ! cofactor transport GO:0051181 19 13 0,000 0,03368313 0,06298471 ! NADP metabolic process GO:0006739 18 13 0,000 0,03368313 0,06293354 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,03368313 0,06288246 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,03368313 0,06283146 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03368313 0,06278054 ! gas transport GO:0015669 18 13 0,000 0,03368313 0,06272971 ! regulation of RNA stability GO:0043487 28 13 0,000 0,03368313 0,06267896 ! heme biosynthetic process GO:0006783 20 13 0,000 0,03368313 0,06262829 ! regulation of axon extension GO:0030516 23 13 0,000 0,03368313 0,0625777 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,03368313 0,06252719 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,03368313 0,06247677 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,03368313 0,06242642 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,03368313 0,06237616 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,03368313 0,06232598 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,03368313 0,06227588 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,03622767 0,06692661 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,03622767 0,0668729 ! superoxide anion generation GO:0042554 18 14 0,000 0,03622767 0,06681927 ! neuron maturation GO:0042551 21 14 0,000 0,03622767 0,06676573 ! regulation of S phase GO:0033261 18 14 0,000 0,03622767 0,06671228 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,03622767 0,06665891 ! myotube differentiation GO:0014902 21 14 0,000 0,03622767 0,06660562 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,03622767 0,06655242 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,03622767 0,06649931 ! inositol metabolic process GO:0006020 20 14 0,000 0,03622767 0,06644628 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,03622767 0,06639333 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,03622767 0,06634047 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,03622767 0,0662877 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,03622767 0,066235 ! gene silencing by RNA GO:0031047 20 14 0,000 0,03622767 0,06618239 ! response to cAMP GO:0051591 19 14 0,000 0,03622767 0,06612987 ! limbic system development GO:0021761 25 14 0,000 0,03622767 0,06607743 ! startle response GO:0001964 21 14 0,000 0,03622767 0,06602507 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,03622767 0,06597279 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,03622767 0,0659206 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,03622767 0,06586848 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,03622767 0,06581646 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,03622767 0,06576451 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,03622767 0,06571264 ! glycine metabolic process GO:0006544 22 14 0,000 0,03622767 0,06566086 ! pituitary gland development GO:0021983 23 14 0,000 0,03622767 0,06560916 ! cellular response to starvation GO:0009267 21 14 0,000 0,03622767 0,06555754 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,03622767 0,065506 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,03622767 0,06545454 ! regulation of heart rate GO:0002027 23 14 0,000 0,03622767 0,06540317 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,03622767 0,06535187 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,03622767 0,06530065 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,03622767 0,06524952 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,03622767 0,06519846 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,03622767 0,06514748 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,03622767 0,06509659 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,03622767 0,06504577 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,03622767 0,06499503 ! axon cargo transport GO:0008088 27 14 0,000 0,03622767 0,06494437 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,03622767 0,0648938 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,03622767 0,06484329 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,03622767 0,06479287 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,03622767 0,06474253 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03622767 0,06469226 ! mRNA splice site selection GO:0006376 26 14 0,000 0,03622767 0,06464207 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,03622767 0,06459196 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,03622767 0,06454193 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,03622767 0,06449198 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,03622767 0,0644421 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,03622767 0,0643923 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,03622767 0,06434257 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,03622767 0,06429293 ! muscle maintenance GO:0046716 19 14 0,000 0,03622767 0,06424336 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,03622767 0,06419386 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,03622767 0,06414444 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,03622767 0,0640951 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,03622767 0,06404584 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,03622767 0,06399665 ! cilium assembly GO:0042384 20 14 0,000 0,03622767 0,06394753 ! peptide hormone secretion GO:0030072 23 14 0,000 0,03622767 0,06389849 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,03876565 0,0683226 ! positive regulation of cell size GO:0045793 20 15 0,000 0,03876565 0,06827029 ! metencephalon development GO:0022037 19 15 0,000 0,03876565 0,06821806 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,03876565 0,0681659 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,03876565 0,06811383 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,03876565 0,06806183 ! skin development GO:0043588 25 15 0,000 0,03876565 0,06800992 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,03876565 0,06795808 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,03876565 0,06790632 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,03876565 0,06785464 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,03876565 0,06780304 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,03876565 0,06775152 ! bile acid metabolic process GO:0008206 22 15 0,000 0,03876565 0,06770008 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,03876565 0,06764871 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,03876565 0,06759742 ! adult walking behavior GO:0007628 25 15 0,000 0,03876565 0,06754621 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,03876565 0,06749508 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,03876565 0,06744402 ! centrosome cycle GO:0007098 16 15 0,000 0,03876565 0,06739305 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,03876565 0,06734214 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,03876565 0,06729132 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,03876565 0,06724057 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,03876565 0,0671899 ! cerebral cortex development GO:0021987 29 15 0,000 0,03876565 0,06713931 ! response to osmotic stress GO:0006970 22 15 0,000 0,03876565 0,06708879 ! vesicle coating GO:0006901 25 15 0,000 0,03876565 0,06703835 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,03876565 0,06698798 ! DNA integration GO:0015074 22 15 0,000 0,03876565 0,06693769 ! peptide secretion GO:0002790 27 15 0,000 0,03876565 0,06688747 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,03876565 0,06683733 ! regulation of vasodilation GO:0042312 24 15 0,000 0,03876565 0,06678727 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,03876565 0,06673727 ! neuron recognition GO:0008038 22 15 0,000 0,03876565 0,06668736 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,03876565 0,06663752 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,03876565 0,06658775 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,03876565 0,06653806 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,03876565 0,06648844 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,03876565 0,0664389 ! biomineral formation GO:0031214 18 15 0,000 0,03876565 0,06638943 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,03876565 0,06634003 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,03876565 0,06629071 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,03876565 0,06624146 ! dopamine metabolic process GO:0042417 30 15 0,000 0,03876565 0,06619228 ! organic cation transport GO:0015695 19 15 0,000 0,03876565 0,06614317 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,03876565 0,06609414 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,03876565 0,06604518 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,03876565 0,0659963 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,03876565 0,06594748 ! defense response to virus GO:0051607 27 15 0,000 0,03876565 0,06589874 ! peptide hormone processing GO:0016486 19 15 0,000 0,03876565 0,06585007 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,03876565 0,06580148 ! protein secretion GO:0009306 27 16 0,000 0,0412971 0,0700467 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,0412971 0,06999508 ! hormone secretion GO:0046879 25 16 0,000 0,0412971 0,06994354 ! bone remodeling GO:0046849 24 16 0,000 0,0412971 0,06989207 ! endothelial cell migration GO:0043542 22 16 0,000 0,0412971 0,06984068 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,0412971 0,06978937 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,0412971 0,06973813 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0412971 0,06968696 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,0412971 0,06963587 ! glial cell development GO:0021782 24 16 0,000 0,0412971 0,06958485 ! patterning of blood vessels GO:0001569 24 16 0,000 0,0412971 0,06953391 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,0412971 0,06948305 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,0412971 0,06943226 ! protein polyubiquitination GO:0000209 26 16 0,000 0,0412971 0,06938154 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,0412971 0,0693309 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,0412971 0,06928033 ! fructose metabolic process GO:0006000 20 16 0,000 0,0412971 0,06922983 ! regulation of protein binding GO:0043393 27 16 0,000 0,0412971 0,06917941 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,0412971 0,06912906 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,0412971 0,06907878 ! protein export from nucleus GO:0006611 24 16 0,000 0,0412971 0,06902858 ! negative regulation of immune response GO:0050777 28 16 0,000 0,0412971 0,06897845 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,0412971 0,06892839 ! DNA replication initiation GO:0006270 25 16 0,000 0,0412971 0,06887841 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,0412971 0,0688285 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,0412971 0,06877866 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,0412971 0,06872889 ! diencephalon development GO:0021536 25 16 0,000 0,0412971 0,0686792 ! oogenesis GO:0048477 23 16 0,000 0,0412971 0,06862957 ! neural crest cell migration GO:0001755 24 16 0,000 0,0412971 0,06858002 ! G1 phase GO:0051318 27 16 0,000 0,0412971 0,06853054 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,0412971 0,06848113 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,0412971 0,06843179 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,0412971 0,06838252 ! steroid catabolic process GO:0006706 22 16 0,000 0,0412971 0,06833333 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,0412971 0,0682842 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,0412971 0,06823515 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,0412971 0,06818616 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,0412971 0,06813725 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,0412971 0,06808841 ! sperm-egg recognition GO:0035036 16 16 0,000 0,0412971 0,06803963 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,0412971 0,06799093 ! nerve development GO:0021675 18 16 0,000 0,0412971 0,06794229 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,0412971 0,06789373 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,0412971 0,06784523 ! negative regulation of translation GO:0017148 22 16 0,000 0,0412971 0,06779681 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,04382202 0,07189062 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,04382202 0,07183938 ! negative regulation of defense response GO:0031348 19 17 0,000 0,04382202 0,07178821 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,04382202 0,07173712 ! glycerol metabolic process GO:0006071 20 17 0,000 0,04382202 0,0716861 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,04382202 0,07163515 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,04382202 0,07158427 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,04382202 0,07153347 ! signal complex assembly GO:0007172 29 17 0,000 0,04382202 0,07148273 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,04382202 0,07143207 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,04382202 0,07138148 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,04382202 0,07133096 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,04382202 0,07128052 ! memory GO:0007613 25 17 0,000 0,04382202 0,07123014 ! keratinization GO:0031424 17 17 0,000 0,04382202 0,07117984 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,04382202 0,07112961 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,04382202 0,07107945 ! retinoid metabolic process GO:0001523 22 17 0,000 0,04382202 0,07102935 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,04382202 0,07097933 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,04382202 0,07092938 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,04382202 0,0708795 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,04382202 0,07082969 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,04382202 0,07077995 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,04382202 0,07073028 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,04382202 0,07068068 ! membrane budding GO:0006900 29 17 0,000 0,04382202 0,07063115 ! heme metabolic process GO:0042168 27 17 0,000 0,04382202 0,07058169 ! neuromuscular junction development GO:0007528 23 17 0,000 0,04382202 0,0705323 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,04382202 0,07048297 ! body fluid secretion GO:0007589 27 17 0,000 0,04382202 0,07043372 ! stem cell differentiation GO:0048863 36 17 0,000 0,04382202 0,07038453 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,04382202 0,07033542 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,04382202 0,07028637 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,04382202 0,07023739 ! sensory perception of pain GO:0019233 23 17 0,000 0,04382202 0,07018848 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,04382202 0,07013963 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,04382202 0,07009086 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,04382202 0,07004215 ! synaptogenesis GO:0007416 24 17 0,000 0,04382202 0,06999351 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,04382202 0,06994494 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,04382202 0,06989643 ! cell-cell junction organization GO:0045216 25 17 0,000 0,04382202 0,06984799 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,04382202 0,06979962 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,04382202 0,06975132 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,04382202 0,06970308 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,04382202 0,06965491 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,04382202 0,0696068 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,04382202 0,06955877 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,04634044 0,07350553 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,04634044 0,07345487 ! positive regulation of translation GO:0045727 28 18 0,000 0,04634044 0,07340428 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,04634044 0,07335376 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,04634044 0,07330331 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,04634044 0,07325293 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,04634044 0,07320262 ! cAMP metabolic process GO:0046058 33 18 0,000 0,04634044 0,07315238 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,04634044 0,07310221 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,04634044 0,0730521 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,04634044 0,07300207 ! axis specification GO:0009798 26 18 0,000 0,04634044 0,0729521 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,04634044 0,0729022 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,04634044 0,07285237 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,04634044 0,07280261 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,04634044 0,07275291 ! glutamine metabolic process GO:0006541 23 18 0,000 0,04634044 0,07270329 ! response to retinoic acid GO:0032526 25 18 0,000 0,04634044 0,07265373 ! pigmentation during development GO:0048066 31 18 0,000 0,04634044 0,07260424 ! central nervous system neuron development GO:0021954 30 18 0,000 0,04634044 0,07255481 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,04634044 0,07250545 ! fucose metabolic process GO:0006004 26 18 0,000 0,04634044 0,07245616 ! response to fungus GO:0009620 19 18 0,000 0,04634044 0,07240694 ! peptide cross-linking GO:0018149 31 18 0,000 0,04634044 0,07235778 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,04634044 0,0723087 ! heart process GO:0003015 27 18 0,000 0,04634044 0,07225967 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,04634044 0,07221072 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,04634044 0,07216183 ! visual learning GO:0008542 35 18 0,000 0,04634044 0,072113 ! somitogenesis GO:0001756 24 18 0,000 0,04634044 0,07206424 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,04634044 0,07201555 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,04634044 0,07196693 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,04634044 0,07191837 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,04634044 0,07186987 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,04634044 0,07182144 ! vitamin transport GO:0051180 24 18 0,000 0,04634044 0,07177308 ! hormone transport GO:0009914 27 18 0,000 0,04634044 0,07172478 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,04634044 0,07167654 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,04634044 0,07162837 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,04634044 0,07158027 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,04634044 0,07153223 ! cell-cell recognition GO:0009988 20 18 0,000 0,04634044 0,07148425 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,04634044 0,07143634 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,04634044 0,07138849 ! regulation of glucose import GO:0046324 21 18 0,000 0,04634044 0,07134071 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,04634044 0,07129299 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,04634044 0,07124533 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,04634044 0,07119774 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,04634044 0,07115021 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,04885237 0,07495694 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,04885237 0,07490697 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,04885237 0,07485707 ! positive regulation of ossification GO:0045778 30 19 0,000 0,04885237 0,07480723 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,04885237 0,07475746 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,04885237 0,07470775 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,04885237 0,07465811 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,04885237 0,07460854 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,04885237 0,07455903 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,04885237 0,07450959 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,04885237 0,07446021 ! regeneration GO:0031099 32 19 0,000 0,04885237 0,0744109 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,04885237 0,07436165 ! response to alkaloid GO:0043279 32 19 0,000 0,04885237 0,07431247 ! sensory perception of taste GO:0050909 23 19 0,000 0,04885237 0,07426335 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,04885237 0,0742143 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 0,000 0,04885237 0,07416532 ! smooth muscle contraction GO:0006939 36 19 0,000 0,04885237 0,0741164 ! peroxisome organization GO:0007031 29 19 0,000 0,04885237 0,07406754 ! digestive system process GO:0022600 30 19 0,000 0,04885237 0,07401875 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,04885237 0,07397002 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,04885237 0,07392135 ! response to vitamin A GO:0033189 26 19 0,000 0,04885237 0,07387275 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,04885237 0,07382421 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,04885237 0,07377574 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,04885237 0,07372733 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,04885237 0,07367899 ! response to starvation GO:0042594 30 19 0,000 0,04885237 0,0736307 ! sex determination GO:0007530 29 19 0,000 0,04885237 0,07358249 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,04885237 0,07353433 ! plasma membrane fusion GO:0045026 23 19 0,000 0,04885237 0,07348624 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,04885237 0,07343821 ! renal system process GO:0003014 35 19 0,000 0,04885237 0,07339024 ! vasodilation GO:0042311 33 19 0,000 0,04885237 0,07334233 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,04885237 0,07329449 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,04885237 0,07324671 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,04885237 0,07319899 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,04885237 0,07315134 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,04885237 0,07310374 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,04885237 0,07305621 ! sarcomere organization GO:0045214 23 19 0,000 0,04885237 0,07300874 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,04885237 0,07296133 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,04885237 0,07291399 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,04885237 0,0728667 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,04885237 0,07281948 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,04885237 0,07277232 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,04885237 0,07272521 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,04885237 0,07267817 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,04885237 0,07263119 ! protein stabilization GO:0050821 26 19 0,000 0,04885237 0,07258427 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,05135783 0,07625759 ! iron ion transport GO:0006826 37 20 0,000 0,05135783 0,07620839 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,05135783 0,07615926 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,05135783 0,07611018 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,05135783 0,07606118 ! response to vitamin GO:0033273 29 20 0,000 0,05135783 0,07601223 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,05135783 0,07596335 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,05135783 0,07591453 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,05135783 0,07586577 ! spinal cord development GO:0021510 31 20 0,000 0,05135783 0,07581708 ! response to ethanol GO:0045471 37 20 0,000 0,05135783 0,07576844 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,05135783 0,07571988 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,05135783 0,07567137 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,05135783 0,07562292 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,05135783 0,07557454 ! chromosome condensation GO:0030261 31 20 0,000 0,05135783 0,07552622 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,05135783 0,07547796 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,05135783 0,07542976 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,05135783 0,07538162 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,05135783 0,07533355 ! pallium development GO:0021543 38 20 0,000 0,05135783 0,07528554 ! DNA modification GO:0006304 28 20 0,000 0,05135783 0,07523758 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,05135783 0,07518969 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,05135783 0,07514186 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,05135783 0,07509409 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,05135783 0,07504638 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,05135783 0,07499873 ! collagen catabolic process GO:0030574 25 20 0,000 0,05135783 0,07495115 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,05135783 0,07490362 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,05135783 0,07485615 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,05135783 0,07480874 ! alditol metabolic process GO:0019400 24 20 0,000 0,05135783 0,0747614 ! actin filament-based movement GO:0030048 34 20 0,000 0,05135783 0,07471411 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,05385683 0,07830007 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,05385683 0,0782506 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,05385683 0,0782012 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,05385683 0,07815186 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,05385683 0,07810259 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,05385683 0,07805337 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,05385683 0,07800422 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,05385683 0,07795513 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,05385683 0,0779061 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,05385683 0,07785714 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,05385683 0,07780823 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,05385683 0,07775939 ! protein amino acid acylation GO:0043543 37 21 0,000 0,05385683 0,07771061 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,05385683 0,07766188 ! vesicle docking GO:0048278 27 21 0,000 0,05385683 0,07761322 ! phototransduction GO:0007602 25 21 0,000 0,05385683 0,07756462 ! dendrite development GO:0016358 35 21 0,000 0,05385683 0,07751609 ! visual behavior GO:0007632 39 21 0,000 0,05385683 0,07746761 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,05385683 0,07741919 ! ovarian follicle development GO:0001541 30 21 0,000 0,05385683 0,07737083 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,05385683 0,07732254 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,05385683 0,0772743 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,05385683 0,07722613 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,05385683 0,07717801 ! cell aging GO:0007569 32 21 0,000 0,05385683 0,07712995 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,05385683 0,07708196 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,05385683 0,07703402 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,05385683 0,07698614 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,05385683 0,07693833 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,05385683 0,07689057 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,05385683 0,07684287 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,05385683 0,07679523 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,05385683 0,07674765 ! fatty acid transport GO:0015908 30 21 0,000 0,05385683 0,07670013 ! immunoglobulin production GO:0002377 33 21 0,000 0,05385683 0,07665266 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,05385683 0,07660526 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,05385683 0,07655791 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,05385683 0,07651063 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,05385683 0,0764634 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,05385683 0,07641623 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,05385683 0,07636912 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,05385683 0,07632206 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,05385683 0,07627507 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,05385683 0,07622813 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,05385683 0,07618125 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,05385683 0,07613442 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,05385683 0,07608766 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,05385683 0,07604095 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,05385683 0,0759943 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,05385683 0,0759477 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,05634939 0,07941397 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,05634939 0,07936534 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,05634939 0,07931676 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,05634939 0,07926825 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,05634939 0,0792198 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,05634939 0,07917141 ! leukocyte adhesion GO:0007159 38 22 0,000 0,05634939 0,07912307 ! molting cycle process GO:0022404 40 22 0,000 0,05634939 0,0790748 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,05634939 0,07902658 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,05634939 0,07897842 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,05634939 0,07893032 ! vasculogenesis GO:0001570 33 22 0,000 0,05634939 0,07888228 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,05634939 0,0788343 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,05634939 0,07878638 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,05634939 0,07873851 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,05634939 0,07869071 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,05634939 0,07864296 ! lysosome organization GO:0007040 37 22 0,000 0,05634939 0,07859527 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,05634939 0,07854763 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,05634939 0,07850006 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,05634939 0,07845254 ! regulation of behavior GO:0050795 38 22 0,000 0,05634939 0,07840508 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,05634939 0,07835767 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,05634939 0,07831033 ! membrane depolarization GO:0051899 35 22 0,000 0,05634939 0,07826304 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,05634939 0,07821581 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,05634939 0,07816863 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,05634939 0,07812152 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,05634939 0,07807445 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,05634939 0,07802745 ! blastocyst development GO:0001824 37 22 0,000 0,05634939 0,0779805 ! neural tube closure GO:0001843 33 22 0,000 0,05634939 0,07793361 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,05634939 0,07788677 ! protein tetramerization GO:0051262 39 22 0,000 0,05634939 0,07784 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,05883552 0,08122551 ! neuron fate commitment GO:0048663 32 23 0,000 0,05883552 0,08117679 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,05883552 0,08112812 ! myelination GO:0042552 35 23 0,000 0,05883552 0,08107951 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,05883552 0,08103096 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,05883552 0,08098247 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,05883552 0,08093403 ! vesicle targeting GO:0006903 32 23 0,000 0,05883552 0,08088566 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,05883552 0,08083734 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,05883552 0,08078908 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,05883552 0,08074087 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,05883552 0,08069273 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,05883552 0,08064464 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,05883552 0,08059661 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,05883552 0,08054863 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,05883552 0,08050072 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,05883552 0,08045286 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,05883552 0,08040505 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,05883552 0,08035731 ! cell fate determination GO:0001709 45 23 0,000 0,05883552 0,08030962 ! pentose metabolic process GO:0019321 31 23 0,000 0,05883552 0,08026198 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,05883552 0,08021441 ! spermatid development GO:0007286 33 23 0,000 0,05883552 0,08016689 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,05883552 0,08011942 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,05883552 0,08007201 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,05883552 0,08002466 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,05883552 0,07997737 ! telomere organization GO:0032200 32 23 0,000 0,05883552 0,07993013 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,05883552 0,07988294 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,05883552 0,07983581 ! regulation of amine transport GO:0051952 38 23 0,000 0,05883552 0,07978874 ! liver development GO:0001889 40 23 0,000 0,05883552 0,07974172 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,06131525 0,08305364 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,06131525 0,08300476 ! initiation of viral infection GO:0019059 42 24 0,000 0,06131525 0,08295593 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,06131525 0,08290716 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,06131525 0,08285845 ! superoxide metabolic process GO:0006801 32 24 0,000 0,06131525 0,08280979 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,06131525 0,0827612 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,06131525 0,08271266 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,06131525 0,08266417 ! sperm motility GO:0030317 27 24 0,000 0,06131525 0,08261575 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,06131525 0,08256738 ! vacuole organization GO:0007033 39 24 0,000 0,06131525 0,08251906 ! receptor metabolic process GO:0043112 37 24 0,000 0,06131525 0,08247081 ! neural crest cell development GO:0014032 39 24 0,000 0,06131525 0,08242261 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,06131525 0,08237446 ! primary neural tube formation GO:0014020 35 24 0,000 0,06131525 0,08232637 ! negative regulation of cell development GO:0010721 56 24 0,000 0,06131525 0,08227834 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,06131525 0,08223037 ! base-excision repair GO:0006284 31 24 0,000 0,06131525 0,08218245 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,06131525 0,08213458 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,06131525 0,08208677 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,06131525 0,08203902 ! glutathione metabolic process GO:0006749 29 24 0,000 0,06131525 0,08199133 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,06131525 0,08194368 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,06131525 0,0818961 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,06378859 0,08515018 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,06378859 0,08510078 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,06378859 0,08505145 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,06378859 0,08500217 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,06378859 0,08495295 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,06378859 0,08490379 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,06378859 0,08485469 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,06378859 0,08480564 ! peptide transport GO:0015833 43 25 0,000 0,06378859 0,08475664 ! male gonad development GO:0008584 33 25 0,000 0,06378859 0,08470771 ! iron ion homeostasis GO:0055072 39 25 0,000 0,06378859 0,08465883 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,06378859 0,08461001 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,06378859 0,08456124 ! phospholipid transport GO:0015914 35 25 0,000 0,06378859 0,08451253 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,06378859 0,08446388 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,06378859 0,08441528 ! detection of light stimulus GO:0009583 30 25 0,000 0,06378859 0,08436673 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,06378859 0,08431825 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,06378859 0,08426982 ! leukocyte proliferation GO:0070661 39 25 0,000 0,06378859 0,08422144 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,06378859 0,08417312 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,06625555 0,0873783 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,06625555 0,08732823 ! translational initiation GO:0006413 43 26 0,000 0,06625555 0,08727821 ! regulation of pH GO:0006885 36 26 0,000 0,06625555 0,08722825 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,06625555 0,08717835 ! circadian rhythm GO:0007623 42 26 0,000 0,06625555 0,08712851 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,06625555 0,08707872 ! post-embryonic development GO:0009791 42 26 0,000 0,06625555 0,08702899 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,06625555 0,08697932 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,06625555 0,0869297 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,06625555 0,08688014 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,06625555 0,08683063 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,06625555 0,08678118 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,06625555 0,08673179 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,06625555 0,08668246 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,06625555 0,08663318 ! regulation of coagulation GO:0050818 39 26 0,000 0,06625555 0,08658395 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,06871615 0,08974852 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,06871615 0,08969758 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,06871615 0,08964671 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,06871615 0,08959589 ! membrane docking GO:0022406 39 27 0,000 0,06871615 0,08954512 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,06871615 0,08949442 ! catechol metabolic process GO:0009712 43 27 0,000 0,06871615 0,08944377 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,06871615 0,08939318 ! acute-phase response GO:0006953 42 27 0,000 0,06871615 0,08934265 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,06871615 0,08929217 ! myofibril assembly GO:0030239 36 27 0,000 0,06871615 0,08924175 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,06871615 0,08919139 ! response to ionizing radiation GO:0010212 47 27 0,000 0,06871615 0,08914108 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,06871615 0,08909084 ! natural killer cell activation GO:0030101 35 27 0,000 0,06871615 0,08904064 ! lipid oxidation GO:0034440 38 27 0,000 0,06871615 0,08899051 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,06871615 0,08894043 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,06871615 0,08889041 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,06871615 0,08884044 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,06871615 0,08879053 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,06871615 0,08874067 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,06871615 0,08869088 ! gene silencing GO:0016458 41 27 0,000 0,06871615 0,08864113 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,07117041 0,09175557 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,07117041 0,09170416 ! phenol metabolic process GO:0018958 44 28 0,000 0,07117041 0,09165282 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,07117041 0,09160153 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,07117041 0,0915503 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,07117041 0,09149912 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,07117041 0,09144801 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,07117041 0,09139695 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,07117041 0,09134594 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,07117041 0,091295 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,07117041 0,09124411 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,07117041 0,09119328 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,07117041 0,0911425 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,07117041 0,09109178 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,07117041 0,09104112 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,07117041 0,09099051 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,07117041 0,09093996 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,07117041 0,09088947 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,07117041 0,09083903 ! ensheathment of neurons GO:0007272 43 28 0,000 0,07117041 0,09078865 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,07117041 0,09073832 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,07117041 0,09068805 ! neural tube formation GO:0001841 41 28 0,000 0,07117041 0,09063784 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,07117041 0,09058768 ! placenta development GO:0001890 37 28 0,000 0,07117041 0,09053757 ! regulation of B cell activation GO:0050864 42 28 0,000 0,07117041 0,09048753 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,07361834 0,09354816 ! regulation of innate immune response GO:0045088 38 29 0,000 0,07361834 0,09349651 ! ovulation cycle process GO:0022602 41 29 0,000 0,07361834 0,09344491 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,07361834 0,09339337 ! protein targeting to membrane GO:0006612 53 29 0,000 0,07361834 0,09334188 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,07361834 0,09329045 ! mismatch repair GO:0006298 34 29 0,000 0,07361834 0,09323908 ! muscle cell development GO:0055001 38 29 0,000 0,07361834 0,09318777 ! telencephalon development GO:0021537 52 29 0,000 0,07361834 0,09313651 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,07361834 0,09308531 ! eye morphogenesis GO:0048592 51 29 0,000 0,07361834 0,09303416 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,07361834 0,09298307 ! tissue homeostasis GO:0001894 42 29 0,000 0,07361834 0,09293204 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,07605995 0,09596154 ! collagen metabolic process GO:0032963 40 30 0,000 0,07605995 0,09590893 ! organic anion transport GO:0015711 51 30 0,000 0,07605995 0,09585638 ! cholesterol transport GO:0030301 46 30 0,000 0,07605995 0,09580388 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,07605995 0,09575145 ! spliceosome assembly GO:0000245 49 30 0,000 0,07605995 0,09569907 ! spindle organization GO:0007051 37 30 0,000 0,07605995 0,09564674 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,07605995 0,09559448 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,07605995 0,09554227 ! ceramide metabolic process GO:0006672 43 30 0,000 0,07605995 0,09549012 ! ovulation cycle GO:0042698 43 30 0,000 0,07605995 0,09543802 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,07605995 0,09538598 ! adult locomotory behavior GO:0008344 47 30 0,000 0,07605995 0,095334 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,07605995 0,09528208 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,07605995 0,09523021 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,07605995 0,0951784 ! response to heat GO:0009408 41 30 0,000 0,07605995 0,09512664 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,07605995 0,09507494 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,07605995 0,0950233 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,07849528 0,09801256 ! negative regulation of secretion GO:0051048 49 31 0,000 0,07849528 0,09795938 ! glial cell differentiation GO:0010001 55 31 0,000 0,07849528 0,09790625 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,07849528 0,09785319 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,07849528 0,09780018 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,07849528 0,09774723 ! odontogenesis GO:0042476 50 31 0,000 0,07849528 0,09769434 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,07849528 0,0976415 ! segmentation GO:0035282 41 31 0,000 0,07849528 0,09758872 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,07849528 0,097536 ! metanephros development GO:0001656 58 31 0,000 0,07849528 0,09748333 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,07849528 0,09743072 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,07849528 0,09737817 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,07849528 0,09732568 ! cell fate specification GO:0001708 37 31 0,000 0,07849528 0,09727324 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,07849528 0,09722086 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,07849528 0,09716853 ! RNA modification GO:0009451 40 31 0,000 0,07849528 0,09711626 ! regulation of muscle development GO:0048634 48 32 0,000 0,08092432 0,1000677 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,08092432 0,10001393 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,08092432 0,09996022 ! meiosis I GO:0007127 52 32 0,000 0,08092432 0,09990656 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,08092432 0,09985297 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,08092432 0,09979943 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,08092432 0,09974594 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,08092432 0,09969252 ! peripheral nervous system development GO:0007422 53 32 0,000 0,08092432 0,09963915 ! regulation of protein stability GO:0031647 48 32 0,000 0,08092432 0,09958584 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,08092432 0,09953258 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,08092432 0,09947939 ! cytokine production GO:0001816 44 32 0,000 0,08092432 0,09942624 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,08092432 0,09937316 ! vesicle localization GO:0051648 47 32 0,000 0,08092432 0,09932013 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,0833471 0,1022391 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,0833471 0,10218461 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,0833471 0,10213017 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,0833471 0,10207578 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,0833471 0,10202146 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,0833471 0,10196719 ! sister chromatid segregation GO:0000819 46 33 0,000 0,0833471 0,10191298 ! ear morphogenesis GO:0042471 42 33 0,000 0,0833471 0,10185883 ! actomyosin structure organization GO:0031032 43 33 0,000 0,0833471 0,10180474 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,0833471 0,1017507 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,0833471 0,10169672 ! nucleus organization GO:0006997 49 33 0,000 0,0833471 0,1016428 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,0833471 0,10158893 ! female gonad development GO:0008585 49 33 0,000 0,0833471 0,10153513 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,0833471 0,10148138 ! positive regulation of cell development GO:0010720 54 33 0,000 0,0833471 0,10142768 ! lipid homeostasis GO:0055088 55 33 0,000 0,0833471 0,10137405 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,0833471 0,10132047 ! regulation of proteolysis GO:0030162 50 33 0,000 0,0833471 0,10126694 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,0833471 0,10121347 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,0833471 0,10116006 ! cytokinesis GO:0000910 52 33 0,000 0,0833471 0,10110671 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,0833471 0,10105341 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,08576363 0,10392852 ! mRNA catabolic process GO:0006402 48 34 0,000 0,08576363 0,1038738 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,08576363 0,10381913 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,08576363 0,10376451 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,08576363 0,10370996 ! feeding behavior GO:0007631 45 34 0,000 0,08576363 0,10365546 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,08576363 0,10360102 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,08576363 0,10354663 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,08576363 0,10349231 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,08576363 0,10343804 ! neuron migration GO:0001764 46 34 0,000 0,08576363 0,10338383 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,08576363 0,10332967 ! female gamete generation GO:0007292 43 34 0,000 0,08576363 0,10327557 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,08576363 0,10322153 ! polyol metabolic process GO:0019751 44 34 0,000 0,08576363 0,10316754 ! aerobic respiration GO:0009060 47 34 0,000 0,08576363 0,10311361 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,08576363 0,10305974 ! embryonic organ development GO:0048568 45 34 0,000 0,08576363 0,10300592 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,08576363 0,10295216 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,08817392 0,10579031 ! Notch signaling pathway GO:0007219 56 35 0,000 0,08817392 0,10573515 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,08817392 0,10568005 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,08817392 0,10562501 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,08817392 0,10557003 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,08817392 0,1055151 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,08817392 0,10546023 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,08817392 0,10540542 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,08817392 0,10535066 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,08817392 0,10529596 ! pigment metabolic process GO:0042440 61 35 0,000 0,08817392 0,10524132 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,08817392 0,10518673 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,090578 0,10799866 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,090578 0,1079427 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,090578 0,1078868 ! negative regulation of binding GO:0051100 58 36 0,000 0,090578 0,10783096 ! tissue remodeling GO:0048771 62 36 0,000 0,090578 0,10777517 ! neural tube development GO:0021915 50 36 0,000 0,090578 0,10771945 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,090578 0,10766378 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,090578 0,10760817 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,090578 0,10755261 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,09297588 0,1103429 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,09297588 0,11028599 ! learning GO:0007612 67 37 0,000 0,09297588 0,11022914 ! ion transmembrane transport GO:0034220 56 37 0,000 0,09297588 0,11017235 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,09297588 0,11011562 ! regulation of protein secretion GO:0050708 51 37 0,000 0,09297588 0,11005895 ! amino acid activation GO:0043038 52 37 0,000 0,09297588 0,11000233 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,09297588 0,10994578 ! gliogenesis GO:0042063 71 38 0,000 0,09536758 0,11271605 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,09536758 0,11265816 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,09536758 0,11260032 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,09536758 0,11254255 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,09536758 0,11248484 ! phagocytosis GO:0006909 60 38 0,000 0,09536758 0,11242718 ! pigmentation GO:0043473 74 38 0,000 0,09536758 0,11236959 ! maintenance of location in cell GO:0051651 69 38 0,000 0,09536758 0,11231205 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,0977531 0,11506251 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,0977531 0,11500365 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,0977531 0,11494486 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,0977531 0,11488612 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,0977531 0,11482745 ! regulation of epithelial cell proliferation GO:0050678 71 39 0,000 0,0977531 0,11476883 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,0977531 0,11471027 ! male sex differentiation GO:0046661 53 39 0,000 0,0977531 0,11465178 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,0977531 0,11459334 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,0977531 0,11453497 ! JNK cascade GO:0007254 54 39 0,000 0,0977531 0,11447665 ! developmental growth GO:0048589 62 39 0,000 0,0977531 0,11441839 ! cell growth GO:0016049 61 39 0,000 0,0977531 0,11436019 ! synapse organization GO:0050808 55 39 0,000 0,0977531 0,11430205 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,10013247 0,11702474 ! response to calcium ion GO:0051592 58 40 0,000 0,10013247 0,11696531 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,10013247 0,11690593 ! regulation of tube size GO:0035150 60 40 0,000 0,10013247 0,11684662 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,10013247 0,11678737 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,10013247 0,11672818 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,10013247 0,11666904 ! peptide metabolic process GO:0006518 56 40 0,000 0,10013247 0,11660997 ! induction of apoptosis by intracellular signals GO:0008629 67 40 0,000 0,10013247 0,11655096 ! inner ear development GO:0048839 57 40 0,000 0,10013247 0,116492 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,10013247 0,11643311 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,10013247 0,11637427 ! double-strand break repair GO:0006302 67 40 0,000 0,10013247 0,1163155 ! B cell differentiation GO:0030183 62 40 0,000 0,10013247 0,11625678 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,10013247 0,11619813 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,10013247 0,11613953 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,10013247 0,11608099 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,10250571 0,11877235 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,10250571 0,11871255 ! glucose transport GO:0015758 52 41 0,000 0,10250571 0,1186528 ! endosome transport GO:0016197 71 41 0,000 0,10250571 0,11859312 ! striated muscle contraction GO:0006941 62 41 0,000 0,10250571 0,1185335 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,10250571 0,11847393 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,10250571 0,11841443 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,10250571 0,11835498 ! biopolymer methylation GO:0043414 62 41 0,000 0,10250571 0,1182956 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,10250571 0,11823627 ! mitochondrial transport GO:0006839 60 42 0,000 0,10487281 0,120906 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,10487281 0,12084543 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,10487281 0,12078491 ! hexose transport GO:0008645 54 42 0,000 0,10487281 0,12072446 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,10487281 0,12066407 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,10487281 0,12060374 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,10487281 0,12054346 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,10487281 0,12048325 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,10487281 0,1204231 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,10487281 0,12036301 ! regulation of cell shape GO:0008360 78 42 0,000 0,10487281 0,12030298 ! positive regulation of binding GO:0051099 59 43 0,000 0,10723381 0,12295004 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 0,000 0,10723381 0,12288878 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,10723381 0,12282758 ! leukocyte migration GO:0050900 60 43 0,000 0,10723381 0,12276644 ! neuromuscular process GO:0050905 79 43 0,000 0,10723381 0,12270536 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,10723381 0,12264434 ! tRNA processing GO:0008033 49 43 0,000 0,10723381 0,12258339 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,10723381 0,12252249 ! vesicle organization GO:0016050 79 43 0,000 0,10723381 0,12246165 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,10723381 0,12240088 ! methylation GO:0032259 64 43 0,000 0,10723381 0,12234017 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,10958872 0,12496483 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,10958872 0,1249029 ! glycolysis GO:0006096 53 44 0,000 0,10958872 0,12484104 ! regulation of action potential GO:0001508 71 44 0,000 0,10958872 0,12477924 ! regulation of ion transport GO:0043269 57 44 0,000 0,10958872 0,1247175 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,10958872 0,12465582 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,10958872 0,1245942 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,10958872 0,12453264 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,10958872 0,12447114 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,10958872 0,1244097 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,10958872 0,12434833 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,10958872 0,12428701 ! regulation of mast cell proliferation GO:0070666 64 44 0,000 0,10958872 0,12422576 ! positive regulation of cell cycle GO:0045787 77 45 0,000 0,11193755 0,1268258 ! RNA catabolic process GO:0006401 64 45 0,000 0,11193755 0,12676335 ! positive regulation of defense response GO:0031349 59 45 0,000 0,11193755 0,12670097 ! regulation of translational initiation GO:0006446 64 45 0,000 0,11193755 0,12663865 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,11193755 0,12657639 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,11193755 0,12651419 ! cell recognition GO:0008037 58 45 0,000 0,11193755 0,12645205 ! cell maturation GO:0048469 60 45 0,000 0,11193755 0,12638997 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,11428032 0,12897191 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,11428032 0,12890865 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,11428032 0,12884546 ! histone modification GO:0016570 68 46 0,000 0,11428032 0,12878233 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,11428032 0,12871927 ! response to UV GO:0009411 75 46 0,000 0,11428032 0,12865626 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,11661705 0,1312227 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,11661705 0,13115854 ! endocrine system development GO:0035270 83 47 0,000 0,11661705 0,13109443 ! covalent chromatin modification GO:0016569 75 47 0,000 0,11661705 0,13103039 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,11661705 0,13096641 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,11661705 0,13090249 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,11661705 0,13083864 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,11661705 0,13077484 ! regulation of leukocyte proliferation GO:0070663 71 47 0,000 0,11661705 0,13071111 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,11661705 0,13064745 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,11661705 0,13058384 ! chloride transport GO:0006821 67 48 0,000 0,11894774 0,13312886 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,11894774 0,1330641 ! response to temperature stimulus GO:0009266 62 48 0,000 0,11894774 0,13299942 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,11894774 0,13293479 ! heart morphogenesis GO:0003007 65 48 0,000 0,11894774 0,13287023 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,11894774 0,13280573 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,11894774 0,13274129 ! regulation of endocytosis GO:0030100 63 48 0,000 0,11894774 0,13267691 ! nuclear export GO:0051168 69 48 0,000 0,11894774 0,1326126 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,11894774 0,13254835 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,11894774 0,13248416 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,12127241 0,13500801 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,12127241 0,1349427 ! sensory perception of smell GO:0007608 61 49 0,000 0,12127241 0,13487744 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,12127241 0,13481225 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,12127241 0,13474713 ! RNA elongation GO:0006354 62 49 0,000 0,12127241 0,13468206 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,12127241 0,13461706 ! germ cell development GO:0007281 68 49 0,000 0,12127241 0,13455212 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,12127241 0,13448725 ! cartilage development GO:0051216 70 49 0,000 0,12127241 0,13442244 ! maintenance of location GO:0051235 84 49 0,000 0,12127241 0,13435768 ! regulation of actin filament length GO:0030832 72 50 0,000 0,12359109 0,13686062 ! ear development GO:0043583 72 50 0,000 0,12359109 0,13679476 ! membrane fusion GO:0006944 80 50 0,000 0,12359109 0,13672896 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,12359109 0,13666322 ! positive regulation of growth GO:0045927 67 50 0,000 0,12359109 0,13659755 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,12359109 0,13653194 ! proton transport GO:0015992 75 50 0,000 0,12359109 0,1364664 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,12359109 0,13640092 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 0,000 0,12590378 0,13888666 ! hydrogen transport GO:0006818 77 51 0,000 0,12590378 0,13882008 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,12590378 0,13875357 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,12590378 0,13868711 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,12590378 0,13862072 ! adult behavior GO:0030534 80 51 0,000 0,12590378 0,1385544 ! transition metal ion transport GO:0000041 74 52 0,000 0,1282105 0,14102542 ! regulation of cellular component size GO:0032535 74 52 0,000 0,1282105 0,14095801 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,1282105 0,14089066 ! aging GO:0007568 79 52 0,000 0,1282105 0,14082338 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,1282105 0,14075616 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,1282105 0,140689 ! establishment of organelle localization GO:0051656 85 52 0,000 0,1282105 0,14062191 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,13051126 0,14307717 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,13051126 0,14300901 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,13051126 0,14294091 ! kidney development GO:0001822 90 53 0,000 0,13051126 0,14287287 ! single fertilization GO:0007338 59 53 0,000 0,13051126 0,1428049 ! cell projection assembly GO:0030031 76 53 0,000 0,13051126 0,142737 ! amino acid transport GO:0006865 84 54 0,000 0,13280609 0,14517776 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,13280609 0,14510879 ! glucose catabolic process GO:0006007 66 54 0,000 0,13280609 0,14503989 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,13280609 0,14497105 ! DNA catabolic process GO:0006308 67 54 0,000 0,13280609 0,14490228 ! detection of external stimulus GO:0009581 66 54 0,000 0,13280609 0,14483357 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,13280609 0,14476493 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,13280609 0,14469635 ! exocytosis GO:0006887 74 55 0,000 0,13509499 0,14712049 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,13509499 0,14705086 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,13509499 0,1469813 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,13737797 0,14939449 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,13737797 0,14932388 ! carbohydrate transport GO:0008643 74 57 0,000 0,13965507 0,15172728 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,13965507 0,15165564 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,13965507 0,15158407 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,13965507 0,15151257 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,13965507 0,15144114 ! camera-type eye development GO:0043010 88 57 0,000 0,13965507 0,15136977 ! secondary metabolic process GO:0019748 84 57 0,000 0,13965507 0,15129847 ! developmental maturation GO:0021700 75 57 0,000 0,13965507 0,15122724 ! gonad development GO:0008406 79 57 0,000 0,13965507 0,15115607 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,14192628 0,15354207 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,14419162 0,15591948 ! activation of MAPK activity GO:0000187 84 59 0,000 0,14419162 0,15584621 ! lung development GO:0030324 94 59 0,000 0,14419162 0,15577301 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,14419162 0,15569988 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,14419162 0,15562681 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,14645112 0,15799136 GO:0035113|embryonic appendage morphogenesis, ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,14645112 0,15791729 ! regulation of heart contraction GO:0008016 91 60 0,000 0,14645112 0,15784329 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,14645112 0,15776936 ! fertilization GO:0009566 68 60 0,000 0,14645112 0,15769549 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,14645112 0,1576217 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,14870478 0,1599724 ! meiosis GO:0007126 96 61 0,000 0,14870478 0,15989761 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,14870478 0,15982289 ! urogenital system development GO:0001655 101 61 0,000 0,14870478 0,15974824 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,14870478 0,15967366 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,14870478 0,15959916 ! extracellular matrix organization GO:0030198 103 61 0,000 0,14870478 0,15952472 ! amine catabolic process GO:0009310 90 62 0,000 0,15095262 0,16186061 ! neurotransmitter transport GO:0006836 81 62 0,000 0,15095262 0,16178519 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,15095262 0,16170984 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,15095262 0,16163455 ! respiratory tube development GO:0030323 99 62 0,000 0,15095262 0,16155934 ! meiotic cell cycle GO:0051321 97 62 0,000 0,15095262 0,16148419 ! organelle localization GO:0051640 96 62 0,000 0,15095262 0,16140912 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,15319465 0,16373034 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,15319465 0,16365429 ! regulation of lipase activity GO:0060191 109 63 0,000 0,15319465 0,16357831 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,15543089 0,16588911 ! negative regulation of cell size GO:0045792 108 64 0,000 0,15543089 0,16581217 ! appendage morphogenesis GO:0035107 93 64 0,000 0,15543089 0,1657353 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,15543089 0,1656585 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,15543089 0,16558177 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,15543089 0,16550511 ! hexose catabolic process GO:0019320 82 64 0,000 0,15543089 0,16542852 ! respiratory system development GO:0060541 100 64 0,000 0,15543089 0,16535201 ! reproductive structure development GO:0048608 90 65 0,000 0,15766135 0,16764729 ! appendage development GO:0048736 94 65 0,000 0,15766135 0,16756982 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,15766135 0,16749242 ! defense response to bacterium GO:0042742 73 65 0,000 0,15766135 0,1674151 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,15766135 0,16733784 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,15766135 0,16726065 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,15988605 0,1695426 ! antigen processing and presentation GO:0019882 96 66 0,000 0,15988605 0,16946447 ! axon guidance GO:0007411 99 66 0,000 0,15988605 0,16938641 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,15988605 0,16930843 ! regulation of immune effector process GO:0002697 101 66 0,000 0,15988605 0,16923051 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,162105 0,17150023 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,162105 0,17142138 ! learning or memory GO:0007611 123 68 0,000 0,16431821 0,17368194 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,16431821 0,17360215 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,16431821 0,17352245 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,16431821 0,17344281 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,16431821 0,17336325 ! rhythmic process GO:0048511 105 68 0,000 0,16431821 0,17328376 ! inorganic anion transport GO:0015698 93 68 0,000 0,16431821 0,17320435 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,16652571 0,17545082 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,16652571 0,17537048 ! response to drug GO:0042493 108 69 0,000 0,16652571 0,17529022 ! response to metal ion GO:0010038 103 70 0,000 0,1687275 0,17752665 ! eye development GO:0001654 111 70 0,000 0,1687275 0,17744548 ! amine transport GO:0015837 101 70 0,000 0,1687275 0,17736438 ! positive regulation of phosphorylation GO:0042327 102 70 0,000 0,1687275 0,17728335 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,1687275 0,1772024 ! regulation of catabolic process GO:0009894 106 70 0,000 0,1687275 0,17712152 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,17092361 0,17934502 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,17092361 0,17926324 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,17092361 0,17918154 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,17092361 0,17909991 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 0,000 0,17311403 0,18131251 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 0,000 0,17311403 0,18122998 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,17311403 0,18114753 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,17311403 0,18106515 ! negative regulation of transport GO:0051051 116 73 0,000 0,1752988 0,18326692 ! regulation of blood pressure GO:0008217 107 73 0,000 0,1752988 0,18318366 ! tube morphogenesis GO:0035239 118 73 0,000 0,1752988 0,18310047 ! mitochondrion organization GO:0007005 104 73 0,000 0,1752988 0,18301736 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,1752988 0,18293432 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,1752988 0,18285135 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,17747791 0,18504044 ! response to oxygen levels GO:0070482 137 74 0,000 0,17747791 0,18495659 ! digestion GO:0007586 97 74 0,000 0,17747791 0,18487283 ! protein import into nucleus GO:0006606 118 74 0,000 0,17747791 0,18478914 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,17747791 0,18470552 ! response to inorganic substance GO:0010035 115 75 0,000 0,1796514 0,18688296 ! negative regulation of growth GO:0045926 123 75 0,000 0,1796514 0,18679847 ! response to nutrient GO:0007584 104 75 0,000 0,1796514 0,18671406 ! nuclear import GO:0051170 121 75 0,000 0,1796514 0,18662973 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,1796514 0,18654547 ! amine biosynthetic process GO:0009309 97 76 0,000 0,18181926 0,18871133 ! tRNA metabolic process GO:0006399 95 76 0,000 0,18181926 0,18862621 ! response to unfolded protein GO:0006986 99 76 0,000 0,18181926 0,18854117 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,18181926 0,1884562 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,18398153 0,19061149 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,18398153 0,19052567 ! regulation of DNA binding GO:0051101 119 77 0,000 0,18398153 0,19043992 ! sex differentiation GO:0007548 105 77 0,000 0,18398153 0,19035425 ! protein ubiquitination GO:0016567 125 77 0,000 0,18398153 0,19026866 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,18398153 0,19018315 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,18398153 0,19009771 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,18398153 0,19001235 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,1861382 0,19215343 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,1861382 0,19206723 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,1861382 0,1919811 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,18828929 0,19411267 ! cellular respiration GO:0045333 107 79 0,000 0,18828929 0,1940257 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,18828929 0,19393881 ! T cell activation GO:0042110 134 79 0,000 0,18828929 0,193852 ! regulation of lyase activity GO:0051339 133 79 0,000 0,18828929 0,19376526 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,18828929 0,19367861 ! alcohol catabolic process GO:0046164 104 80 0,000 0,19043482 0,19579798 ! protein localization in nucleus GO:0034504 133 80 0,000 0,19043482 0,1957105 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,19043482 0,19562309 ! forebrain development GO:0030900 131 80 0,000 0,19043482 0,19553575 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,19257481 0,19764483 ! response to protein stimulus GO:0051789 111 81 0,000 0,19257481 0,19755667 ! regulation of neurological system process GO:0031644 122 81 0,000 0,19257481 0,19746859 ! vitamin metabolic process GO:0006766 103 81 0,000 0,19257481 0,19738059 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,19257481 0,19729267 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 0,000 0,19470926 0,1993906 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,19683819 0,20148101 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,19683819 0,20139138 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,19683819 0,20130183 ! regulation of defense response GO:0031347 117 84 0,000 0,19896161 0,20338298 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,19896161 0,20329263 ! sterol metabolic process GO:0016125 120 84 0,000 0,19896161 0,20320235 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,20107954 0,20527427 ! rRNA metabolic process GO:0016072 107 85 0,000 0,20107954 0,2051832 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 0,000 0,20107954 0,20509221 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,20107954 0,2050013 ! regulation of membrane potential GO:0042391 128 85 0,000 0,20107954 0,20491047 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,20107954 0,20481973 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,20319199 0,20687985 ! interphase of mitotic cell cycle GO:0051329 156 86 0,000 0,20319199 0,20678831 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,20529898 0,20884018 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,20529898 0,20874786 ! female pregnancy GO:0007565 130 87 0,000 0,20529898 0,20865561 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,20740052 0,21069841 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,20740052 0,21060538 ! interphase GO:0051325 159 88 0,000 0,20740052 0,21051244 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,20740052 0,21041958 GO:0016054|organic acid catabolic process, ! regulation of neurogenesis GO:0050767 153 89 0,000 0,20949662 0,21245248 ! reproductive developmental process GO:0003006 127 89 0,000 0,20949662 0,21235885 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,20949662 0,2122653 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,20949662 0,21217183 ! regulation of T cell activation GO:0050863 128 89 0,000 0,20949662 0,21207844 ! leukocyte differentiation GO:0002521 143 90 0,000 0,2115873 0,21410065 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,2115873 0,2140065 ! hormone metabolic process GO:0042445 121 90 0,000 0,2115873 0,21391243 ! ATP metabolic process GO:0046034 137 91 0,000 0,21367256 0,2159257 ! response to virus GO:0009615 122 91 0,000 0,21367256 0,21583087 ! DNA recombination GO:0006310 146 92 0,000 0,21575244 0,21783609 ! sulfur metabolic process GO:0006790 118 92 0,000 0,21575244 0,2177405 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,21782693 0,21973769 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,21782693 0,21964136 ! response to oxidative stress GO:0006979 141 94 0,000 0,21989605 0,22163055 ! regulation of binding GO:0051098 151 95 0,000 0,22195982 0,22361261 ! angiogenesis GO:0001525 149 95 0,000 0,22195982 0,2235147 ! carboxylic acid transport GO:0046942 147 95 0,000 0,22195982 0,22341688 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,22401824 0,22539018 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,22401824 0,22529163 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,22401824 0,22519316 ! response to light stimulus GO:0009416 153 96 0,000 0,22401824 0,22509478 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,22607134 0,22705855 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,22607134 0,22695944 ! calcium ion transport GO:0006816 167 99 0,000 0,23016161 0,23096496 ! extracellular structure organization GO:0043062 156 99 0,000 0,23016161 0,23086424 ! protein import GO:0017038 156 99 0,000 0,23016161 0,2307636 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,23016161 0,23066305 ! regulation of translation GO:0006417 151 100 0,000 0,2321988 0,23260333 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,2321988 0,23250207 ! divalent metal ion transport GO:0070838 171 100 0,000 0,2321988 0,23240089 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,2321988 0,2322998 ! protein localization in organelle GO:0033365 161 100 0,000 0,2321988 0,2321988