pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1229-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! BMP signaling pathway GO:0030509 40 28 5,000 1,024E-08 2,356E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 3,000 6,932E-08 7,972E-05 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 6,000 1,446E-07 1,109E-04 ! regulation of bone remodeling GO:0046850 90 53 5,000 5,561E-07 3,198E-04 ! regulation of tissue remodeling GO:0034103 91 54 5,000 6,227E-07 2,865E-04 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 4,000 2,393E-06 9,172E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 3,587E-06 1,179E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 4,486E-06 1,29E-03 ! positive regulation of osteoblast differentiation GO:0045669 33 20 3,000 4,551E-06 1,163E-03 ! regulation of ossification GO:0030278 71 46 4,000 6,302E-06 1,449E-03 ! cartilage development GO:0051216 70 49 4,000 8,648E-06 1,808E-03 ! regulation of osteoblast differentiation GO:0045667 37 24 3,000 9,808E-06 1,88E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 2,000 9,961E-06 1,762E-03 ! regulation of hormone metabolic process GO:0032350 15 9 2,000 1,488E-05 2,444E-03 ! mesoderm development GO:0007498 76 55 4,000 1,535E-05 2,354E-03 ! detection of bacterium GO:0016045 10 10 2,000 2,117E-05 3,043E-03 ! regulation of homeostatic process GO:0032844 105 60 4,000 2,357E-05 3,189E-03 ! cell-matrix adhesion GO:0007160 114 61 4,000 2,556E-05 3,265E-03 ! mesoderm morphogenesis GO:0048332 49 31 3,000 2,816E-05 3,409E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 2,898E-05 3,333E-03 ! focal adhesion formation GO:0048041 24 11 2,000 2,898E-05 3,175E-03 ! cell-substrate adhesion GO:0031589 121 66 4,000 3,753E-05 3,924E-03 ! cartilage condensation GO:0001502 18 12 2,000 3,849E-05 3,849E-03 ! positive regulation of bone mineralization GO:0030501 19 13 2,000 4,982E-05 4,775E-03 ! response to hypoxia GO:0001666 132 72 4,000 5,719E-05 5,262E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 6,315E-05 5,586E-03 ! positive regulation of biomineral formation GO:0070169 20 14 2,000 6,315E-05 5,379E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 6,315E-05 5,187E-03 ! epithelial to mesenchymal transition GO:0001837 22 14 2,000 6,315E-05 5,008E-03 ! mesenchymal cell development GO:0014031 64 38 3,000 6,407E-05 4,912E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 3,000 6,407E-05 4,754E-03 ! response to oxygen levels GO:0070482 137 74 4,000 6,525E-05 4,69E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 7,861E-05 5,479E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 7,861E-05 5,318E-03 ! oogenesis GO:0048477 23 16 2,000 9,635E-05 6,331E-03 ! detection of biotic stimulus GO:0009595 19 16 2,000 9,635E-05 6,155E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 1,165E-04 7,242E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 1,165E-04 7,052E-03 ! stem cell differentiation GO:0048863 36 17 2,000 1,165E-04 6,871E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 1,165E-04 6,699E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 1,165E-04 6,536E-03 ! anterior/posterior pattern formation GO:0009952 124 85 4,000 1,264E-04 6,924E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 4,000 1,336E-04 7,148E-03 ! axis specification GO:0009798 26 18 2,000 1,392E-04 7,278E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 1,392E-04 7,116E-03 ! response to retinoic acid GO:0032526 25 18 2,000 1,392E-04 6,961E-03 ! interphase GO:0051325 159 88 4,000 1,49E-04 7,291E-03 ! positive regulation of ossification GO:0045778 30 19 2,000 1,646E-04 7,889E-03 ! response to alkaloid GO:0043279 32 19 2,000 1,646E-04 7,728E-03 ! response to vitamin A GO:0033189 26 19 2,000 1,646E-04 7,574E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 1,646E-04 7,425E-03 ! regulation of angiogenesis GO:0045765 94 49 3,000 1,753E-04 7,752E-03 ! response to vitamin GO:0033273 29 20 2,000 1,929E-04 8,371E-03 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 1,932E-04 8,231E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 2,049E-04 8,569E-03 ! positive regulation of bone remodeling GO:0046852 33 21 2,000 2,241E-04 9,205E-03 GO:0034105|positive regulation of tissue remodeling, ! ovarian follicle development GO:0001541 30 21 2,000 2,241E-04 9,043E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 2,241E-04 8,887E-03 ! regulation of bone mineralization GO:0030500 29 21 2,000 2,241E-04 8,737E-03 ! skeletal system morphogenesis GO:0048705 78 53 3,000 2,38E-04 9,124E-03 ! detection of external stimulus GO:0009581 66 54 3,000 2,559E-04 9,65E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 2,947E-04 0,01093117 ! embryonic pattern specification GO:0009880 31 23 2,000 2,96E-04 0,01080493 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 2,96E-04 0,0106361 ! regulation of biomineral formation GO:0070167 31 23 2,000 2,96E-04 0,01047247 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 3,155E-04 0,0109955 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,203E-04 0,01099649 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 3,203E-04 0,01083478 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 3,203E-04 0,01067775 ! embryonic hemopoiesis GO:0035162 10 5 1,000 3,203E-04 0,01052521 ! positive regulation of glycolysis GO:0045821 11 5 1,000 3,203E-04 0,01037697 ! epithelial cell proliferation GO:0050673 6 5 1,000 3,203E-04 0,01023285 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 3,203E-04 0,01009267 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 3,203E-04 9,956E-03 ! regulation of centrosome cycle GO:0046605 7 5 1,000 3,203E-04 9,824E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 3,203E-04 9,694E-03 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 3,203E-04 9,568E-03 GO:0045686|negative regulation of glial cell differentiation, ! positive regulation of chemokine production GO:0032722 7 5 1,000 3,203E-04 9,446E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 3,203E-04 9,326E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 3,203E-04 9,21E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 3,203E-04 9,096E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 3,368E-04 9,448E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 3,368E-04 9,334E-03 ! fat cell differentiation GO:0045444 37 24 2,000 3,368E-04 9,223E-03 ! negative regulation of cell development GO:0010721 56 24 2,000 3,368E-04 9,114E-03 GO:0050768|negative regulation of neurogenesis, ! lung development GO:0030324 94 59 3,000 3,604E-04 9,638E-03 ! iron ion homeostasis GO:0055072 39 25 2,000 3,812E-04 0,01007737 ! regulation of chromosome organization GO:0033044 35 25 2,000 3,812E-04 9,963E-03 ! respiratory tube development GO:0030323 99 62 3,000 4,36E-04 0,01126643 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 4,787E-04 0,01223358 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 4,787E-04 0,01209914 ! mRNA stabilization GO:0048255 15 6 1,000 4,787E-04 0,01196763 GO:0043489|RNA stabilization, ! pigment granule organization GO:0048753 11 6 1,000 4,787E-04 0,01183895 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 1,000 4,787E-04 0,011713 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! ER overload response GO:0006983 7 6 1,000 4,787E-04 0,01158971 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 4,787E-04 0,01146898 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 4,787E-04 0,01135074 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 4,787E-04 0,01123492 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 1,000 4,787E-04 0,01112143 ! gas homeostasis GO:0033483 11 6 1,000 4,787E-04 0,01101022 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 4,787E-04 0,01090121 ! midbrain development GO:0030901 6 6 1,000 4,787E-04 0,01079433 ! respiratory system development GO:0060541 100 64 3,000 4,922E-04 0,01099166 ! cell junction assembly GO:0034329 56 28 2,000 5,362E-04 0,01185891 ! mesoderm formation GO:0001707 46 28 2,000 5,362E-04 0,01174597 ! ovulation cycle process GO:0022602 41 29 2,000 5,956E-04 0,01292398 ! formation of primary germ layer GO:0001704 48 29 2,000 5,956E-04 0,0128032 ! spindle organization GO:0007051 37 30 2,000 6,591E-04 0,01403576 ! ovulation cycle GO:0042698 43 30 2,000 6,591E-04 0,01390699 ! hindbrain development GO:0030902 45 30 2,000 6,591E-04 0,01378056 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 6,677E-04 0,01383495 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 6,677E-04 0,01371142 ! T-helper 1 type immune response GO:0042088 11 7 1,000 6,677E-04 0,01359008 ! hemoglobin metabolic process GO:0020027 10 7 1,000 6,677E-04 0,01347087 ! regulation of pigmentation during development GO:0048070 15 7 1,000 6,677E-04 0,01335373 ! organ growth GO:0035265 11 7 1,000 6,677E-04 0,01323862 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 6,677E-04 0,01312547 ! behavioral fear response GO:0001662 13 7 1,000 6,677E-04 0,01301423 GO:0002209|behavioral defense response, ! response to UV-B GO:0010224 11 7 1,000 6,677E-04 0,01290487 ! B cell lineage commitment GO:0002326 17 7 1,000 6,677E-04 0,01279733 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 6,677E-04 0,01269157 ! transcription from RNA polymerase I promoter GO:0006360 12 7 1,000 6,677E-04 0,01258754 ! T cell lineage commitment GO:0002360 12 7 1,000 6,677E-04 0,0124852 ! neuroblast proliferation GO:0007405 13 7 1,000 6,677E-04 0,01238451 ! peptidyl-threonine modification GO:0018210 18 7 1,000 6,677E-04 0,01228544 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 6,677E-04 0,01218793 ! segmentation GO:0035282 41 31 2,000 7,267E-04 0,01316012 ! steroid biosynthetic process GO:0006694 94 71 3,000 7,301E-04 0,01311886 ! cell junction organization GO:0034330 63 33 2,000 8,747E-04 0,01559625 ! carbohydrate homeostasis GO:0033500 39 33 2,000 8,747E-04 0,01547628 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 2,000 8,747E-04 0,01535814 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 8,869E-04 0,01545406 ! induction of positive chemotaxis GO:0050930 14 8 1,000 8,869E-04 0,01533786 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 8,869E-04 0,0152234 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 8,869E-04 0,01511064 ! macrophage activation GO:0042116 12 8 1,000 8,869E-04 0,01499953 ! regulation of vascular permeability GO:0043114 12 8 1,000 8,869E-04 0,01489004 ! retinal ganglion cell axon guidance GO:0031290 10 8 1,000 8,869E-04 0,01478214 ! regulation of telomere maintenance GO:0032204 10 8 1,000 8,869E-04 0,0146758 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 8,869E-04 0,01457097 ! middle ear morphogenesis GO:0042474 9 8 1,000 8,869E-04 0,01446763 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 8,869E-04 0,01436575 ! melanin metabolic process GO:0006582 12 8 1,000 8,869E-04 0,01426529 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 8,869E-04 0,01416622 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 1,000 8,869E-04 0,01406852 GO:0007351|tripartite regional subdivision, ! regulation of gliogenesis GO:0014013 20 8 1,000 8,869E-04 0,01397216 GO:0045685|regulation of glial cell differentiation, ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 8,869E-04 0,01387712 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 8,869E-04 0,01378335 ! negative regulation of growth GO:0045926 123 75 3,000 8,975E-04 0,01385412 ! response to nutrient GO:0007584 104 75 3,000 8,975E-04 0,01376176 ! female gamete generation GO:0007292 43 34 2,000 9,554E-04 0,01455298 ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 9,554E-04 0,01445723 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 9,554E-04 0,01436274 ! sex differentiation GO:0007548 105 77 3,000 9,906E-04 0,01479476 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 1,041E-03 0,01544248 ! tissue remodeling GO:0048771 62 36 2,000 1,131E-03 0,01666922 ! development of primary female sexual characteristics GO:0046545 52 36 2,000 1,131E-03 0,01656304 GO:0046660|female sex differentiation, ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,136E-03 0,01653796 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 1,136E-03 0,01643394 ! regulation of glycolysis GO:0006110 15 9 1,000 1,136E-03 0,01633123 ! lung alveolus development GO:0048286 17 9 1,000 1,136E-03 0,0162298 ! T cell selection GO:0045058 18 9 1,000 1,136E-03 0,01612961 ! endoderm development GO:0007492 12 9 1,000 1,136E-03 0,01603066 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 1,136E-03 0,01593291 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,136E-03 0,01583635 ! blastoderm segmentation GO:0007350 11 9 1,000 1,136E-03 0,01574095 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 1,136E-03 0,01564669 ! oocyte differentiation GO:0009994 12 9 1,000 1,136E-03 0,01555355 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 1,136E-03 0,01546152 ! spleen development GO:0048536 15 9 1,000 1,136E-03 0,01537057 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 1,136E-03 0,01528068 ! anterior/posterior axis specification GO:0009948 11 9 1,000 1,136E-03 0,01519184 ! embryonic placenta development GO:0001892 12 9 1,000 1,136E-03 0,01510403 ! response to nicotine GO:0035094 16 9 1,000 1,136E-03 0,01501722 ! detection of stimulus GO:0051606 108 82 3,000 1,253E-03 0,01646457 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,415E-03 0,01848906 ! hair follicle morphogenesis GO:0031069 17 10 1,000 1,415E-03 0,0183846 ! hippocampus development GO:0021766 19 10 1,000 1,415E-03 0,01828132 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 1,415E-03 0,01817919 ! blood vessel remodeling GO:0001974 21 10 1,000 1,415E-03 0,01807819 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,415E-03 0,01797831 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,415E-03 0,01787953 ! B cell proliferation GO:0042100 14 10 1,000 1,415E-03 0,01778183 ! fear response GO:0042596 16 10 1,000 1,415E-03 0,01768519 ! negative regulation of ossification GO:0030279 19 10 1,000 1,415E-03 0,01758959 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 1,415E-03 0,01749503 ! regulation of bone resorption GO:0045124 24 10 1,000 1,415E-03 0,01740147 ! alpha-beta T cell activation GO:0046631 16 10 1,000 1,415E-03 0,01730891 ! embryonic axis specification GO:0000578 12 10 1,000 1,415E-03 0,01721733 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,415E-03 0,01712671 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,415E-03 0,01703704 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 1,429E-03 0,01712179 ! male sex differentiation GO:0046661 53 39 2,000 1,429E-03 0,01703307 ! developmental growth GO:0048589 62 39 2,000 1,429E-03 0,01694527 ! regulation of protein localization GO:0032880 132 85 3,000 1,431E-03 0,01688325 ! cell cycle arrest GO:0007050 150 86 3,000 1,495E-03 0,01753999 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 1,539E-03 0,0179658 ! positive regulation of protein transport GO:0051222 55 40 2,000 1,539E-03 0,01787506 ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 1,56E-03 0,0180295 ! anatomical structure homeostasis GO:0060249 136 88 3,000 1,627E-03 0,01871202 ! regulation of neurogenesis GO:0050767 153 89 3,000 1,696E-03 0,01941049 ! reproductive developmental process GO:0003006 127 89 3,000 1,696E-03 0,0193144 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,723E-03 0,01951915 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 1,723E-03 0,01942347 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 1,000 1,723E-03 0,01932872 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 1,723E-03 0,01923489 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 1,723E-03 0,01914197 ! stem cell development GO:0048864 29 11 1,000 1,723E-03 0,01904994 GO:0019827|stem cell maintenance, ! T cell homeostasis GO:0043029 20 11 1,000 1,723E-03 0,0189588 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,723E-03 0,01886852 ! digestive tract morphogenesis GO:0048546 15 11 1,000 1,723E-03 0,01877909 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 1,773E-03 0,01923852 ! response to insulin stimulus GO:0032868 63 43 2,000 1,898E-03 0,02049944 ! cell fate commitment GO:0045165 141 92 3,000 1,916E-03 0,02059324 ! negative regulation of cell migration GO:0030336 92 44 2,000 2,029E-03 0,0217049 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 2,06E-03 0,02193131 ! heart looping GO:0001947 15 12 1,000 2,06E-03 0,02183024 ! palate development GO:0060021 15 12 1,000 2,06E-03 0,0217301 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 2,06E-03 0,02163088 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 2,06E-03 0,02153256 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 2,06E-03 0,02143512 ! gland morphogenesis GO:0022612 23 12 1,000 2,06E-03 0,02133857 ! peptidyl-lysine modification GO:0018205 18 12 1,000 2,06E-03 0,02124288 ! response to gamma radiation GO:0010332 20 12 1,000 2,06E-03 0,02114805 ! regulation of mRNA stability GO:0043488 27 12 1,000 2,06E-03 0,02105406 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,06E-03 0,0209609 ! regulation of binding GO:0051098 151 95 3,000 2,155E-03 0,02183283 ! response to UV GO:0009411 75 46 2,000 2,306E-03 0,02326631 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 2,425E-03 0,02435646 ! regulation of chemokine production GO:0032642 17 13 1,000 2,425E-03 0,02425056 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 2,425E-03 0,02414558 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 2,425E-03 0,02404151 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 2,425E-03 0,02393832 ! cellular pigmentation GO:0033059 24 13 1,000 2,425E-03 0,02383602 ! regulation of RNA stability GO:0043487 28 13 1,000 2,425E-03 0,02373459 ! lymphocyte homeostasis GO:0002260 24 13 1,000 2,425E-03 0,02363402 ! gastrulation GO:0007369 73 48 2,000 2,606E-03 0,02529315 ! regulation of intracellular transport GO:0032386 78 49 2,000 2,765E-03 0,02671904 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 2,819E-03 0,02712564 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 2,819E-03 0,02701261 ! retina development in camera-type eye GO:0060041 18 14 1,000 2,819E-03 0,02690053 ! limbic system development GO:0021761 25 14 1,000 2,819E-03 0,02678937 ! epidermis morphogenesis GO:0048730 29 14 1,000 2,819E-03 0,02667913 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 2,819E-03 0,02656979 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 27 14 1,000 2,819E-03 0,02646134 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 2,819E-03 0,02635377 ! muscle maintenance GO:0046716 19 14 1,000 2,819E-03 0,02624708 ! ear development GO:0043583 72 50 2,000 2,929E-03 0,02716608 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 3,099E-03 0,02862974 ! positive regulation of organelle organization GO:0010638 82 51 2,000 3,099E-03 0,02851522 ! negative regulation of cell motion GO:0051271 104 51 2,000 3,099E-03 0,02840161 ! metencephalon development GO:0022037 19 15 1,000 3,24E-03 0,02957381 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 3,24E-03 0,02945692 ! lipid phosphorylation GO:0046834 23 15 1,000 3,24E-03 0,02934095 ! myoblast differentiation GO:0045445 27 15 1,000 3,24E-03 0,02922589 ! regulation of survival gene product expression GO:0045884 20 15 1,000 3,24E-03 0,02911172 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 3,24E-03 0,02899845 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 3,24E-03 0,02888605 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 3,24E-03 0,02877452 ! defense response to virus GO:0051607 27 15 1,000 3,24E-03 0,02866385 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 3,689E-03 0,03251189 ! protein amino acid acetylation GO:0006473 28 16 1,000 3,689E-03 0,03238779 ! regulation of protein binding GO:0043393 27 16 1,000 3,689E-03 0,03226465 ! DNA replication initiation GO:0006270 25 16 1,000 3,689E-03 0,03214243 ! neural crest cell migration GO:0001755 24 16 1,000 3,689E-03 0,03202114 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 3,689E-03 0,03190076 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 3,689E-03 0,03178128 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 4,166E-03 0,03575107 ! regulation of viral genome replication GO:0045069 24 17 1,000 4,166E-03 0,03561817 ! actin filament bundle formation GO:0051017 26 17 1,000 4,166E-03 0,03548625 ! multicellular organism reproduction GO:0032504 83 57 2,000 4,249E-03 0,03605794 GO:0048609|reproductive process in a multicellular organism, ! gonad development GO:0008406 79 57 2,000 4,249E-03 0,03592538 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 4,669E-03 0,0393367 ! transcription from RNA polymerase III promoter GO:0006383 32 18 1,000 4,669E-03 0,03919314 ! pancreas development GO:0031016 26 18 1,000 4,669E-03 0,03905062 ! pigmentation during development GO:0048066 31 18 1,000 4,669E-03 0,03890913 ! somitogenesis GO:0001756 24 18 1,000 4,669E-03 0,03876866 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 4,669E-03 0,03862921 ! gut development GO:0048565 26 18 1,000 4,669E-03 0,03849075 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 4,669E-03 0,03835328 ! actin filament organization GO:0007015 95 59 2,000 4,682E-03 0,03831936 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 5,199E-03 0,04240344 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 5,199E-03 0,04225361 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regeneration GO:0031099 32 19 1,000 5,199E-03 0,04210482 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 5,199E-03 0,04195709 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 5,199E-03 0,04181039 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 5,199E-03 0,0416647 ! apoptotic nuclear changes GO:0030262 24 19 1,000 5,199E-03 0,04152004 ! plasma membrane fusion GO:0045026 23 19 1,000 5,199E-03 0,04137637 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 5,199E-03 0,04123369 ! renal system process GO:0003014 35 19 1,000 5,199E-03 0,04109199 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 5,199E-03 0,04095127 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 5,199E-03 0,0408115 ! negative regulation of cell growth GO:0030308 106 62 2,000 5,38E-03 0,04208586 ! hindlimb morphogenesis GO:0035137 32 20 1,000 5,755E-03 0,04487158 ! response to ethanol GO:0045471 37 20 1,000 5,755E-03 0,04471998 ! multicellular organismal response to stress GO:0033555 32 20 1,000 5,755E-03 0,04456941 ! pallium development GO:0021543 38 20 1,000 5,755E-03 0,04441985 ! positive regulation of locomotion GO:0040017 35 20 1,000 5,755E-03 0,04427129 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of B cell activation GO:0050871 31 20 1,000 5,755E-03 0,04412372 ! cell cycle checkpoint GO:0000075 108 64 2,000 5,878E-03 0,04491444 ! negative regulation of cell size GO:0045792 108 64 2,000 5,878E-03 0,04476572 ! appendage morphogenesis GO:0035107 93 64 2,000 5,878E-03 0,04461798 GO:0035108|limb morphogenesis, ! reproductive structure development GO:0048608 90 65 2,000 6,137E-03 0,04643186 ! regulation of caspase activity GO:0043281 97 65 2,000 6,137E-03 0,04627963 ! appendage development GO:0048736 94 65 2,000 6,137E-03 0,04612839 GO:0060173|limb development, ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 6,337E-03 0,04747959 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 6,337E-03 0,04732544 ! protein amino acid acylation GO:0043543 37 21 1,000 6,337E-03 0,04717228 ! regulation of chemotaxis GO:0050920 36 21 1,000 6,337E-03 0,04702011 ! cell aging GO:0007569 32 21 1,000 6,337E-03 0,04686892 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 6,337E-03 0,0467187 ! regulation of insulin secretion GO:0050796 26 21 1,000 6,337E-03 0,04656944 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 6,337E-03 0,04642113 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 6,337E-03 0,04627376 ! response to cytokine stimulus GO:0034097 47 21 1,000 6,337E-03 0,04612733 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 6,676E-03 0,04843519 ! regulation of neuron differentiation GO:0045664 107 67 2,000 6,676E-03 0,04828288 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 6,945E-03 0,05007655 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 6,945E-03 0,04992006 ! viral genome replication GO:0019079 29 22 1,000 6,945E-03 0,04976455 ! molting cycle process GO:0022404 40 22 1,000 6,945E-03 0,04961 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 6,945E-03 0,04945641 ! vasculogenesis GO:0001570 33 22 1,000 6,945E-03 0,04930377 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 6,945E-03 0,04915206 GO:0010810|regulation of cell-substrate adhesion, ! barbed-end actin filament capping GO:0051016 33 22 1,000 6,945E-03 0,04900129 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 1,000 6,945E-03 0,04885144 ! regulation of behavior GO:0050795 38 22 1,000 6,945E-03 0,0487025 ! leukocyte homeostasis GO:0001776 33 22 1,000 6,945E-03 0,04855447 ! development of primary sexual characteristics GO:0045137 92 68 2,000 6,955E-03 0,0484751 ! rhythmic process GO:0048511 105 68 2,000 6,955E-03 0,04832865 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 7,579E-03 0,0525029 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 7,579E-03 0,05234524 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 7,579E-03 0,05218852 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 7,579E-03 0,05203273 ! osteoblast differentiation GO:0001649 40 23 1,000 7,579E-03 0,05187787 ! regulation of viral reproduction GO:0050792 32 23 1,000 7,579E-03 0,05172393 ! lymphocyte proliferation GO:0046651 36 23 1,000 7,579E-03 0,0515709 ! cellular response to oxidative stress GO:0034599 33 23 1,000 7,579E-03 0,05141877 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 7,579E-03 0,05126754 ! regulation of peptidase activity GO:0052547 106 72 2,000 8,142E-03 0,05491761 ! negative regulation of organelle organization GO:0010639 115 72 2,000 8,142E-03 0,05475703 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 8,237E-03 0,05523372 ! mitochondrial membrane organization GO:0007006 39 24 1,000 8,237E-03 0,05507316 ! neural crest cell development GO:0014032 39 24 1,000 8,237E-03 0,05491353 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 8,237E-03 0,05475482 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 8,237E-03 0,05459702 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 8,237E-03 0,05444014 ! mitochondrion organization GO:0007005 104 73 2,000 8,456E-03 0,05572942 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 8,778E-03 0,05768128 ! negative regulation of actin filament depolymerization GO:0030835 36 25 1,000 8,92E-03 0,0584511 ! negative regulation of actin filament polymerization GO:0030837 36 25 1,000 8,92E-03 0,05828504 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 8,92E-03 0,05811993 GO:0045936|negative regulation of phosphate metabolic process, ! male gonad development GO:0008584 33 25 1,000 8,92E-03 0,05795575 ! regulation of peptide secretion GO:0002791 34 25 1,000 8,92E-03 0,05779249 ! positive regulation of nuclear division GO:0051785 39 25 1,000 8,92E-03 0,05763016 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 8,92E-03 0,05746873 ! leukocyte proliferation GO:0070661 39 25 1,000 8,92E-03 0,0573082 GO:0032943|mononuclear cell proliferation, ! regulation of protein transport GO:0051223 114 76 2,000 9,441E-03 0,06048792 GO:0070201|regulation of establishment of protein localization, ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 9,628E-03 0,0615105 ! post-embryonic development GO:0009791 42 26 1,000 9,628E-03 0,06134011 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 9,628E-03 0,06117067 ! negative regulation of protein polymerization GO:0032272 38 26 1,000 9,628E-03 0,06100215 ! regulation of DNA binding GO:0051101 119 77 2,000 9,784E-03 0,06182182 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 0,01035949 0,06527897 ! response to ionizing radiation GO:0010212 47 27 1,000 0,01035949 0,06510061 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01035949 0,06492322 ! negative regulation of protein complex assembly GO:0031333 42 28 1,000 0,01111512 0,06946952 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01111512 0,06928126 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01111512 0,06909401 ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,01111512 0,06890777 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01111512 0,06872254 ! placenta development GO:0001890 37 28 1,000 0,01111512 0,0685383 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01111512 0,06835504 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,0112264 0,06885527 ! ossification GO:0001503 134 82 2,000 0,01160515 0,07098894 GO:0060348|bone development, ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,01189435 0,07256497 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01189435 0,072373 ! telencephalon development GO:0021537 52 29 1,000 0,01189435 0,07218204 ! tissue homeostasis GO:0001894 42 29 1,000 0,01189435 0,07199209 GO:0048871|multicellular organismal homeostasis, ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,01238458 0,07476254 ! collagen metabolic process GO:0032963 40 30 1,000 0,01269687 0,07644709 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01269687 0,07624749 ! response to heat GO:0009408 41 30 1,000 0,01269687 0,07604893 ! transcription initiation GO:0006352 118 85 2,000 0,0127853 0,07637974 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,0127853 0,07618186 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,0135224 0,08036566 ! odontogenesis GO:0042476 50 31 1,000 0,0135224 0,08015853 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,0135224 0,07995247 ! metanephros development GO:0001656 58 31 1,000 0,0135224 0,07974746 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,0135224 0,07954351 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,0135224 0,07934059 ! leukocyte chemotaxis GO:0030595 43 31 1,000 0,0135224 0,0791387 GO:0060326|cell chemotaxis, ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,01360888 0,07944269 GO:0060538|skeletal muscle organ development, ! regulation of muscle development GO:0048634 48 32 1,000 0,01437065 0,08367723 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,01437065 0,08346592 ! meiosis I GO:0007127 52 32 1,000 0,01437065 0,08325568 ! regulation of protein stability GO:0031647 48 32 1,000 0,01437065 0,08304649 ! sister chromatid segregation GO:0000819 46 33 1,000 0,01524136 0,08785745 ! ear morphogenesis GO:0042471 42 33 1,000 0,01524136 0,08763781 ! nucleus organization GO:0006997 49 33 1,000 0,01524136 0,08741926 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,01524136 0,0872018 ! positive regulation of cell development GO:0010720 54 33 1,000 0,01524136 0,08698542 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,01524136 0,08677011 ! cytokinesis GO:0000910 52 33 1,000 0,01524136 0,08655586 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,01613423 0,0914008 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,01613423 0,09117623 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,01613423 0,09095276 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,01613423 0,09073038 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 0,01613423 0,09050908 ! embryonic organ development GO:0048568 45 34 1,000 0,01613423 0,09028887 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,01625781 0,09075961 ! response to oxidative stress GO:0006979 141 94 2,000 0,01672544 0,09314409 ! glycogen metabolic process GO:0005977 48 35 1,000 0,01704899 0,0947166 ! pigment metabolic process GO:0042440 61 35 1,000 0,01704899 0,09448837 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,01704899 0,09426123 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 0,01704899 0,09403519 ! angiogenesis GO:0001525 149 95 2,000 0,01720057 0,09464427 ! response to light stimulus GO:0009416 153 96 2,000 0,01768321 0,09706772 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01798536 0,09849128 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,01798536 0,09825733 ! regulation of hormone secretion GO:0046883 48 36 1,000 0,01798536 0,09802449 ! glucan metabolic process GO:0044042 49 36 1,000 0,01798536 0,09779276 GO:0006073|cellular glucan metabolic process, ! phagocytosis GO:0006909 60 38 1,000 0,01992187 0,10806677 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,02092147 0,11322209 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,02092147 0,11295631 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,02092147 0,11269178 ! chromatin remodeling GO:0006338 68 39 1,000 0,02092147 0,11242848 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,02194161 0,11763569 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,02194161 0,11736212 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,02194161 0,11708982 ! T cell differentiation GO:0030217 65 40 1,000 0,02194161 0,11681878 ! B cell differentiation GO:0030183 62 40 1,000 0,02194161 0,11654899 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,02194161 0,11628044 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,02298203 0,12151419 ! glucose transport GO:0015758 52 41 1,000 0,02298203 0,12123549 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,02298203 0,12095806 ! mitochondrial transport GO:0006839 60 42 1,000 0,02404247 0,12625041 ! cellular component disassembly GO:0022411 64 42 1,000 0,02404247 0,12596282 ! hexose transport GO:0008645 54 42 1,000 0,02404247 0,12567654 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,02404247 0,12539156 ! regulation of cell shape GO:0008360 78 42 1,000 0,02404247 0,12510787 ! positive regulation of binding GO:0051099 59 43 1,000 0,02512267 0,13043371 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,02512267 0,13013994 ! leukocyte migration GO:0050900 60 43 1,000 0,02512267 0,12984749 ! activation of caspase activity GO:0006919 65 43 1,000 0,02512267 0,12955635 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,02512267 0,12926652 ! vesicle organization GO:0016050 79 43 1,000 0,02512267 0,12897798 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,02512267 0,12869072 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,02622237 0,13402544 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,02622237 0,13372826 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,02734132 0,13912619 ! regulation of translational initiation GO:0006446 64 45 1,000 0,02734132 0,13881906 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,02734132 0,1385133 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02827871 0,14294731 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02827871 0,14263383 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02827871 0,14232172 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02827871 0,14201098 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02827871 0,14170159 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02827871 0,14139354 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02827871 0,14108683 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02827871 0,14078145 ! sleep GO:0030431 11 5 0,000 0,02827871 0,14047738 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02827871 0,14017463 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02827871 0,13987318 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02827871 0,13957302 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02827871 0,13927415 ! tongue development GO:0043586 6 5 0,000 0,02827871 0,13897656 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02827871 0,13868023 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02827871 0,13838517 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02827871 0,13809135 ! cobalt ion transport GO:0006824 9 5 0,000 0,02827871 0,13779879 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02827871 0,13750746 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02827871 0,13721736 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02827871 0,13692848 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02827871 0,13664082 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02827871 0,13635436 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02827871 0,1360691 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02827871 0,13578503 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02827871 0,13550214 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02827871 0,13522043 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02827871 0,13493989 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02827871 0,13466051 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02827871 0,13438229 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02827871 0,13410521 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02827871 0,13382928 ! malate metabolic process GO:0006108 7 5 0,000 0,02827871 0,13355447 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02827871 0,1332808 ! behavioral response to pain GO:0048266 7 5 0,000 0,02827871 0,13300824 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02827871 0,13273679 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02827871 0,13246645 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02827871 0,13219721 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02827871 0,13192906 ! mating behavior GO:0007617 6 5 0,000 0,02827871 0,131662 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02827871 0,13139602 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02827871 0,13113111 ! rhythmic behavior GO:0007622 12 5 0,000 0,02827871 0,13086726 ! copulation GO:0007620 7 5 0,000 0,02827871 0,13060447 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02827871 0,13034274 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02827871 0,13008206 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02827871 0,12982241 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02827871 0,1295638 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02827871 0,12930622 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02827871 0,12904966 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02827871 0,12879412 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02827871 0,12853958 ! response to protozoan GO:0001562 9 5 0,000 0,02827871 0,12828605 ! lymph vessel development GO:0001945 7 5 0,000 0,02827871 0,12803352 ! endochondral ossification GO:0001958 12 5 0,000 0,02827871 0,12778198 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02827871 0,12753143 ! parathyroid gland development GO:0060017 8 5 0,000 0,02827871 0,12728186 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02827871 0,12703326 ! anagen GO:0042640 6 5 0,000 0,02827871 0,12678563 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02827871 0,12653897 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02827871 0,12629326 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02827871 0,1260485 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,02827871 0,1258047 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02827871 0,12556183 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02827871 0,1253199 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02827871 0,1250789 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02827871 0,12483883 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02827871 0,12459967 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02827871 0,12436143 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02827871 0,1241241 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02827871 0,12388767 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02827871 0,12365214 ! ovulation GO:0030728 6 5 0,000 0,02827871 0,12341751 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02827871 0,12318377 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02827871 0,1229509 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,02827871 0,12271892 ! response to pH GO:0009268 9 5 0,000 0,02827871 0,12248781 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02827871 0,12225757 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02827871 0,1220282 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02827871 0,12179968 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02827871 0,12157202 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02827871 0,1213452 ! polyol catabolic process GO:0046174 7 5 0,000 0,02827871 0,12111923 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02827871 0,1208941 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02827871 0,12066981 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02827871 0,12044635 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02827871 0,12022371 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02827871 0,1200019 ! urea metabolic process GO:0019627 6 5 0,000 0,02827871 0,1197809 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02827871 0,11956071 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02827871 0,11934134 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02827871 0,11912276 ! neutrophil activation GO:0042119 5 5 0,000 0,02827871 0,11890499 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02827871 0,11868801 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02827871 0,11847182 ! response to food GO:0032094 5 5 0,000 0,02827871 0,11825641 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02827871 0,11804179 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02827871 0,11782795 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02827871 0,11761488 ! forebrain neuron development GO:0021884 7 5 0,000 0,02827871 0,11740258 ! melanosome organization GO:0032438 7 5 0,000 0,02827871 0,11719104 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02827871 0,11698027 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02827871 0,11677025 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02827871 0,11656098 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02827871 0,11635247 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02827871 0,11614469 ! nucleoside transport GO:0015858 6 5 0,000 0,02827871 0,11593766 ! nucleoside salvage GO:0043174 7 5 0,000 0,02827871 0,11573137 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02827871 0,1155258 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02827871 0,11532097 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02827871 0,11511686 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02827871 0,11491348 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02827871 0,11471081 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02827871 0,11450885 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02827871 0,11430761 ! depyrimidination GO:0045008 8 5 0,000 0,02827871 0,11410707 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02827871 0,11390723 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02827871 0,11370809 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02827871 0,11350965 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02827871 0,1133119 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02827871 0,11311483 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02827871 0,11291845 ! monocyte differentiation GO:0030224 8 5 0,000 0,02827871 0,11272275 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02827871 0,11252773 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02827871 0,11233338 ! centrosome duplication GO:0051298 5 5 0,000 0,02827871 0,1121397 ! response to UV-C GO:0010225 6 5 0,000 0,02827871 0,11194669 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02827871 0,11175434 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02827871 0,11156266 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02827871 0,11137162 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02827871 0,11118124 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02827871 0,11099152 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02827871 0,11080243 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02827871 0,11061399 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02827871 0,11042619 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02827871 0,11023903 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02827871 0,1100525 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02827871 0,1098666 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02827871 0,10968133 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02827871 0,10949668 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02827871 0,10931265 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02827871 0,10912924 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02827871 0,10894645 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02827871 0,10876426 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02827871 0,10858268 ! neural tube patterning GO:0021532 6 5 0,000 0,02827871 0,10840171 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02827871 0,10822134 ! histone demethylation GO:0016577 9 5 0,000 0,02827871 0,10804157 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02827871 0,1078624 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02827871 0,10768382 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02827871 0,10750583 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02827871 0,10732843 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02827871 0,10715161 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02827871 0,10697538 ! transcription termination GO:0006353 8 5 0,000 0,02827871 0,10679972 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02827871 0,10662464 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,02827871 0,10645013 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,02827871 0,10627619 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,02827871 0,10610282 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02827871 0,10593001 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02827871 0,10575777 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02827871 0,10558608 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02827871 0,10541496 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02827871 0,10524438 ! apical protein localization GO:0045176 6 5 0,000 0,02827871 0,10507436 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02827871 0,10490488 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02827871 0,10473596 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02827871 0,10456757 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02827871 0,10439972 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02827871 0,10423242 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02827871 0,10406564 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02827871 0,10389941 ! glial cell migration GO:0008347 10 5 0,000 0,02827871 0,1037337 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02827871 0,10356852 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02827871 0,10340386 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02827871 0,10323973 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02827871 0,10307611 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02827871 0,10291302 ! neural plate development GO:0001840 6 5 0,000 0,02827871 0,10275044 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02827871 0,10258837 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02827871 0,10242682 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02827871 0,10226577 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02827871 0,10210522 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02827871 0,10194519 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02827871 0,10178565 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02827871 0,10162661 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02827871 0,10146806 ! spindle assembly GO:0051225 5 5 0,000 0,02827871 0,10131001 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02827871 0,10115245 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02827871 0,10099539 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02827871 0,1008388 ! organ regeneration GO:0031100 7 5 0,000 0,02827871 0,10068271 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02827871 0,10052709 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02827871 0,10037196 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02827871 0,1002173 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02827871 0,10006312 GO:0055081|anion homeostasis, ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,02847927 0,10061801 ! histone modification GO:0016570 68 46 1,000 0,02847927 0,10046369 ! viral infectious cycle GO:0019058 71 47 1,000 0,02963597 0,10438397 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,02963597 0,10422437 ! covalent chromatin modification GO:0016569 75 47 1,000 0,02963597 0,10406524 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,02963597 0,10390661 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,02963597 0,10374846 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,02963597 0,10359078 ! regulation of protein polymerization GO:0032271 71 47 1,000 0,02963597 0,10343359 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,03081118 0,10737228 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 1,000 0,03081118 0,10720984 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,03081118 0,10704789 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,03081118 0,10688643 ! heart morphogenesis GO:0003007 65 48 1,000 0,03081118 0,10672546 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,03081118 0,10656497 ! RNA elongation GO:0006354 62 49 1,000 0,03200464 0,11052652 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,03200464 0,11036081 ! germ cell development GO:0007281 68 49 1,000 0,03200464 0,1101956 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,03200464 0,11003089 ! regulation of actin filament length GO:0030832 72 50 1,000 0,03321611 0,11402546 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,03321611 0,11385553 ! membrane fusion GO:0006944 80 50 1,000 0,03321611 0,1136861 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,03321611 0,11351717 ! lipid modification GO:0030258 73 50 1,000 0,03321611 0,11334875 ! positive regulation of growth GO:0045927 67 50 1,000 0,03321611 0,11318083 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,03321611 0,1130134 ! tRNA transcription GO:0009304 11 6 0,000 0,03383871 0,11496164 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03383871 0,11479208 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03383871 0,11462302 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03383871 0,11445445 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03383871 0,11428639 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03383871 0,11411881 ! regulation of helicase activity GO:0051095 11 6 0,000 0,03383871 0,11395173 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03383871 0,11378513 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03383871 0,11361902 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03383871 0,1134534 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03383871 0,11328825 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03383871 0,11312359 ! prostate gland development GO:0030850 9 6 0,000 0,03383871 0,1129594 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03383871 0,11279569 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03383871 0,11263246 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03383871 0,1124697 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03383871 0,1123074 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03383871 0,11214558 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03383871 0,11198421 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03383871 0,11182332 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03383871 0,11166288 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03383871 0,11150291 ! neuron adhesion GO:0007158 9 6 0,000 0,03383871 0,11134339 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03383871 0,11118433 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03383871 0,11102572 ! signal peptide processing GO:0006465 8 6 0,000 0,03383871 0,11086756 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03383871 0,11070986 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03383871 0,1105526 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03383871 0,11039579 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03383871 0,11023942 ! opsonization GO:0008228 8 6 0,000 0,03383871 0,11008349 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03383871 0,10992801 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03383871 0,10977296 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03383871 0,10961835 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03383871 0,10946418 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03383871 0,10931043 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03383871 0,10915712 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03383871 0,10900424 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03383871 0,10885179 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03383871 0,10869976 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03383871 0,10854816 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03383871 0,10839698 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03383871 0,10824622 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03383871 0,10809587 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03383871 0,10794595 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03383871 0,10779644 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03383871 0,10764734 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03383871 0,10749866 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03383871 0,10735039 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03383871 0,10720252 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03383871 0,10705506 ! thymic T cell selection GO:0045061 12 6 0,000 0,03383871 0,10690801 ! protein lipoylation GO:0009249 10 6 0,000 0,03383871 0,10676136 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03383871 0,10661511 ! drug transport GO:0015893 6 6 0,000 0,03383871 0,10646926 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03383871 0,10632381 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,03383871 0,10617876 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03383871 0,1060341 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03383871 0,10588984 ! histidine metabolic process GO:0006547 6 6 0,000 0,03383871 0,10574596 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03383871 0,10560248 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03383871 0,10545939 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 0,03383871 0,10531668 ! adenohypophysis development GO:0021984 10 6 0,000 0,03383871 0,10517436 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03383871 0,10503243 ! hyperosmotic response GO:0006972 8 6 0,000 0,03383871 0,10489088 ! microtubule nucleation GO:0007020 10 6 0,000 0,03383871 0,1047497 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03383871 0,10460891 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03383871 0,1044685 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03383871 0,10432846 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03383871 0,10418879 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03383871 0,1040495 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03383871 0,10391059 ! response to dietary excess GO:0002021 7 6 0,000 0,03383871 0,10377204 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03383871 0,10363386 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03383871 0,10349605 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03383871 0,1033586 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03383871 0,10322152 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03383871 0,10308481 ! neuron apoptosis GO:0051402 8 6 0,000 0,03383871 0,10294845 ! organic alcohol transport GO:0015850 9 6 0,000 0,03383871 0,10281246 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03383871 0,10267682 ! male sex determination GO:0030238 9 6 0,000 0,03383871 0,10254154 ! carnitine transport GO:0015879 8 6 0,000 0,03383871 0,10240662 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03383871 0,10227205 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03383871 0,10213783 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03383871 0,10200397 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03383871 0,10187046 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03383871 0,10173729 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03383871 0,10160448 ! parturition GO:0007567 12 6 0,000 0,03383871 0,10147201 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03383871 0,10133988 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03383871 0,1012081 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03383871 0,10107666 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03383871 0,10094556 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03383871 0,1008148 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03383871 0,10068438 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03383871 0,1005543 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03383871 0,10042455 ! macrophage differentiation GO:0030225 10 6 0,000 0,03383871 0,10029514 ! astrocyte development GO:0014002 14 6 0,000 0,03383871 0,10016606 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03383871 0,10003731 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03383871 0,0999089 ! interaction with symbiont GO:0051702 8 6 0,000 0,03383871 0,09978081 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03383871 0,09965305 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03383871 0,09952561 ! eating behavior GO:0042755 6 6 0,000 0,03383871 0,0993985 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03383871 0,09927172 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03383871 0,09914526 ! response to copper ion GO:0046688 9 6 0,000 0,03383871 0,09901912 ! DNA topological change GO:0006265 8 6 0,000 0,03383871 0,0988933 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03383871 0,0987678 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,03383871 0,09864262 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03383871 0,09851776 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03383871 0,09839321 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03383871 0,09826898 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03383871 0,09814506 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03383871 0,09802145 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03383871 0,09789815 ! hair follicle maturation GO:0048820 7 6 0,000 0,03383871 0,09777516 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03383871 0,09765248 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03383871 0,09753011 ! Schwann cell development GO:0014044 14 6 0,000 0,03383871 0,09740805 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03383871 0,09728629 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03383871 0,09716483 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03383871 0,09704368 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03383871 0,09692283 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03383871 0,09680228 ! histone ubiquitination GO:0016574 7 6 0,000 0,03383871 0,09668202 ! regulation of meiosis GO:0040020 10 6 0,000 0,03383871 0,09656207 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03383871 0,09644242 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03383871 0,09632306 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03383871 0,09620399 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03383871 0,09608522 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03383871 0,09596674 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03383871 0,09584856 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03383871 0,09573066 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03383871 0,09561306 ! receptor internalization GO:0031623 9 6 0,000 0,03383871 0,09549574 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03383871 0,09537871 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03383871 0,09526197 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03383871 0,09514551 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03383871 0,09502934 ! protein deubiquitination GO:0016579 8 6 0,000 0,03383871 0,09491345 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03383871 0,09479784 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,03383871 0,09468252 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03383871 0,09456747 ! axonal fasciculation GO:0007413 9 6 0,000 0,03383871 0,09445271 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03383871 0,09433822 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03383871 0,09422401 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03383871 0,09411007 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03383871 0,09399641 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03383871 0,09388303 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03383871 0,09376991 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03383871 0,09365708 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03383871 0,09354451 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03383871 0,09343221 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03383871 0,09332018 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03383871 0,09320842 ! adult feeding behavior GO:0008343 6 6 0,000 0,03383871 0,09309693 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03383871 0,0929857 ! blastocyst growth GO:0001832 15 6 0,000 0,03383871 0,09287474 ! pigment granule transport GO:0051904 12 6 0,000 0,03383871 0,09276404 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03383871 0,09265361 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03383871 0,09254344 ! catecholamine transport GO:0051937 7 6 0,000 0,03383871 0,09243353 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03383871 0,09232388 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03383871 0,09221449 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03383871 0,09210536 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03383871 0,09199649 ! protein prenylation GO:0018342 10 6 0,000 0,03383871 0,09188787 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03383871 0,09177952 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03383871 0,09167141 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03383871 0,09156356 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03383871 0,09145597 ! positive regulation of secretion GO:0051047 71 51 1,000 0,03444536 0,09298631 ! muscle fiber development GO:0048747 74 51 1,000 0,03444536 0,0928773 ! regulation of cellular component size GO:0032535 74 52 1,000 0,03569215 0,0961264 ! aging GO:0007568 79 52 1,000 0,03569215 0,09601397 ! establishment of organelle localization GO:0051656 85 52 1,000 0,03569215 0,0959018 ! kidney development GO:0001822 90 53 1,000 0,03695623 0,09918242 ! regulation of protein complex assembly GO:0043254 81 54 1,000 0,03823738 0,10250115 ! regulation of mitosis GO:0007088 84 54 1,000 0,03823738 0,10238182 GO:0051783|regulation of nuclear division, ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,03823738 0,10226277 ! DNA catabolic process GO:0006308 67 54 1,000 0,03823738 0,102144 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,03936721 0,10504012 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03936721 0,10491841 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03936721 0,10479698 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03936721 0,10467582 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03936721 0,10455495 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03936721 0,10443436 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03936721 0,10431404 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03936721 0,104194 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03936721 0,10407424 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03936721 0,10395475 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03936721 0,10383554 ! reproductive behavior GO:0019098 12 7 0,000 0,03936721 0,1037166 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03936721 0,10359793 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,03936721 0,10347953 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03936721 0,1033614 ! oligopeptide transport GO:0006857 11 7 0,000 0,03936721 0,10324354 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03936721 0,10312595 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03936721 0,10300863 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03936721 0,10289158 ! RNA methylation GO:0001510 11 7 0,000 0,03936721 0,10277479 ! pericardium development GO:0060039 8 7 0,000 0,03936721 0,10265826 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03936721 0,102542 ! fibril organization GO:0043206 13 7 0,000 0,03936721 0,102426 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03936721 0,10231027 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03936721 0,10219479 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03936721 0,10207958 ! lipoprotein transport GO:0042953 9 7 0,000 0,03936721 0,10196463 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03936721 0,10184993 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03936721 0,10173549 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03936721 0,10162131 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03936721 0,10150739 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03936721 0,10139372 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03936721 0,1012803 ! chemosensory behavior GO:0007635 9 7 0,000 0,03936721 0,10116714 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03936721 0,10105423 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03936721 0,10094157 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03936721 0,10082916 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03936721 0,10071701 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03936721 0,1006051 ! reflex GO:0060004 12 7 0,000 0,03936721 0,10049344 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03936721 0,10038203 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03936721 0,10027086 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03936721 0,10015994 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03936721 0,10004927 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03936721 0,09993884 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03936721 0,09982865 ! spinal cord patterning GO:0021511 7 7 0,000 0,03936721 0,09971871 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03936721 0,09960901 ! adrenal gland development GO:0030325 17 7 0,000 0,03936721 0,09949955 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03936721 0,09939033 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03936721 0,09928135 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03936721 0,0991726 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03936721 0,0990641 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03936721 0,09895583 ! endosome organization GO:0007032 10 7 0,000 0,03936721 0,0988478 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03936721 0,09874001 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,03936721 0,09863245 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03936721 0,09852512 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03936721 0,09841803 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03936721 0,09831117 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03936721 0,09820454 ! galactose metabolic process GO:0006012 10 7 0,000 0,03936721 0,09809814 ! vesicle fusion GO:0006906 15 7 0,000 0,03936721 0,09799198 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03936721 0,09788604 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03936721 0,09778033 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03936721 0,09767485 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03936721 0,0975696 ! retinol metabolic process GO:0042572 9 7 0,000 0,03936721 0,09746457 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03936721 0,09735977 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03936721 0,0972552 ! rRNA modification GO:0000154 12 7 0,000 0,03936721 0,09715085 ! protein heterooligomerization GO:0051291 10 7 0,000 0,03936721 0,09704672 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03936721 0,09694281 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,03936721 0,09683913 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03936721 0,09673567 ! intermediate filament organization GO:0045109 11 7 0,000 0,03936721 0,09663243 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03936721 0,09652941 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03936721 0,09642661 ! fibrinolysis GO:0042730 9 7 0,000 0,03936721 0,09632403 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,03936721 0,09622167 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03936721 0,09611952 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03936721 0,09601759 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03936721 0,09591588 ! response to tropane GO:0014073 13 7 0,000 0,03936721 0,09581438 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03936721 0,09571309 ! melanosome localization GO:0032400 10 7 0,000 0,03936721 0,09561202 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03936721 0,09551117 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03936721 0,09541052 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03936721 0,09531009 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03936721 0,09520987 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03936721 0,09510986 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03936721 0,09501006 ! mast cell activation GO:0045576 9 7 0,000 0,03936721 0,09491047 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03936721 0,09481109 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03936721 0,09471191 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,03936721 0,09461294 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03936721 0,09451418 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03936721 0,09441563 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,03936721 0,09431728 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03936721 0,09421913 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03936721 0,09412119 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03936721 0,09402346 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03936721 0,09392592 ! response to tumor cell GO:0002347 12 7 0,000 0,03936721 0,09382859 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03936721 0,09373146 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03936721 0,09363453 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03936721 0,0935378 ! diuresis GO:0030146 12 7 0,000 0,03936721 0,09344127 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03936721 0,09334494 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,03936721 0,0932488 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03936721 0,09315287 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03936721 0,09305713 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03936721 0,09296159 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03936721 0,09286624 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03936721 0,09277109 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03936721 0,09267614 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03936721 0,09258138 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03936721 0,09248681 ! lymph node development GO:0048535 9 7 0,000 0,03936721 0,09239244 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03936721 0,09229825 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03936721 0,09220426 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03936721 0,09211047 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03936721 0,09201686 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03936721 0,09192344 ! ATP catabolic process GO:0006200 10 7 0,000 0,03936721 0,09183021 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03936721 0,09173717 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03936721 0,09164432 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03936721 0,09155166 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03936721 0,09145918 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03936721 0,09136689 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03936721 0,09127479 ! muscle adaptation GO:0043500 12 7 0,000 0,03936721 0,09118287 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03936721 0,09109113 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03936721 0,09099959 ! retina homeostasis GO:0001895 9 7 0,000 0,03936721 0,09090822 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03936721 0,09081704 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03936721 0,09072604 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03936721 0,09063522 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03936721 0,09054459 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03936721 0,09045413 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03936721 0,09036386 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03936721 0,09027377 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,04084995 0,09358057 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 0,04218091 0,09653343 ! carbohydrate transport GO:0008643 74 57 1,000 0,04218091 0,09643747 ! chromosome segregation GO:0007059 83 57 1,000 0,04218091 0,0963417 ! camera-type eye development GO:0043010 88 57 1,000 0,04218091 0,09624613 ! secondary metabolic process GO:0019748 84 57 1,000 0,04218091 0,09615074 ! negative regulation of kinase activity GO:0033673 100 58 1,000 0,04352802 0,09912321 ! viral reproductive process GO:0022415 87 58 1,000 0,04352802 0,09902517 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,04352802 0,09892732 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0448644 0,10186388 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0448644 0,10176342 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,0448644 0,10166316 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,0448644 0,1015631 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0448644 0,10146323 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,0448644 0,10136357 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,0448644 0,10126409 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0448644 0,10116481 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,0448644 0,10106573 ! phosphate transport GO:0006817 10 8 0,000 0,0448644 0,10096684 ! N-glycan processing GO:0006491 12 8 0,000 0,0448644 0,10086814 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0448644 0,10076964 ! UTP metabolic process GO:0046051 8 8 0,000 0,0448644 0,10067133 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0448644 0,10057321 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0448644 0,10047528 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0448644 0,10037754 ! succinate metabolic process GO:0006105 14 8 0,000 0,0448644 0,10027999 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,0448644 0,10018263 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0448644 0,10008546 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,0448644 0,09998848 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0448644 0,09989168 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,0448644 0,09979508 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0448644 0,09969866 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0448644 0,09960242 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0448644 0,09950637 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0448644 0,09941051 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0448644 0,09931483 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0448644 0,09921934 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0448644 0,09912402 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,0448644 0,0990289 ! astrocyte differentiation GO:0048708 16 8 0,000 0,0448644 0,09893395 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0448644 0,09883919 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0448644 0,0987446 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0448644 0,0986502 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,0448644 0,09855598 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,0448644 0,09846194 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0448644 0,09836807 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0448644 0,09827439 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0448644 0,09818088 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,0448644 0,09808756 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,0448644 0,09799441 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0448644 0,09790143 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,0448644 0,09780863 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0448644 0,09771601 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0448644 0,09762357 ! ruffle organization GO:0031529 11 8 0,000 0,0448644 0,09753129 ! osteoblast development GO:0002076 13 8 0,000 0,0448644 0,0974392 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0448644 0,09734727 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0448644 0,09725552 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,0448644 0,09716394 ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,0448644 0,09707254 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,0448644 0,09698131 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,0448644 0,09689024 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0448644 0,09679935 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0448644 0,09670863 ! brain morphogenesis GO:0048854 20 8 0,000 0,0448644 0,09661808 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0448644 0,0965277 ! segment specification GO:0007379 10 8 0,000 0,0448644 0,09643749 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,0448644 0,09634744 ! cellular extravasation GO:0045123 11 8 0,000 0,0448644 0,09625756 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0448644 0,09616786 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0448644 0,09607831 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0448644 0,09598894 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,0448644 0,09589973 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0448644 0,09581069 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0448644 0,09572181 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,0448644 0,09563309 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,0448644 0,09554455 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0448644 0,09545616 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0448644 0,09536794 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0448644 0,09527988 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0448644 0,09519198 ! icosanoid secretion GO:0032309 12 8 0,000 0,0448644 0,09510425 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,0448644 0,09501668 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,0448644 0,09492926 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,0448644 0,09484201 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,0448644 0,09475492 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,0448644 0,09466799 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0448644 0,09458122 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0448644 0,09449461 ! sterol catabolic process GO:0016127 9 8 0,000 0,0448644 0,09440815 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0448644 0,09432185 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,0448644 0,09423572 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0448644 0,09414973 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0448644 0,09406391 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,0448644 0,09397824 ! prophase GO:0051324 11 8 0,000 0,0448644 0,09389273 ! S phase GO:0051320 8 8 0,000 0,0448644 0,09380737 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0448644 0,09372217 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,0448644 0,09363712 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0448644 0,09355223 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0448644 0,09346749 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0448644 0,0933829 ! hormone catabolic process GO:0042447 13 8 0,000 0,0448644 0,09329847 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0448644 0,09321419 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,0448644 0,09313006 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,0448644 0,09304609 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0448644 0,09296226 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,0448644 0,09287859 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0448644 0,09279506 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0448644 0,09271169 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,0448644 0,09262846 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,0448644 0,09254539 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0448644 0,09246246 ! lamellipodium assembly GO:0030032 9 8 0,000 0,0448644 0,09237969 ! regulation of embryonic development GO:0045995 16 8 0,000 0,0448644 0,09229706 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,0448644 0,09221457 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,0448644 0,09213224 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,04489105 0,09210474 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,04626978 0,09484893 ! meiosis GO:0007126 96 61 1,000 0,047664 0,09761994 GO:0051327|M phase of meiotic cell cycle, ! urogenital system development GO:0001655 101 61 1,000 0,047664 0,09753309 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,047664 0,0974464 ! negative regulation of transferase activity GO:0051348 105 61 1,000 0,047664 0,09735985 ! meiotic cell cycle GO:0051321 97 62 1,000 0,04907348 0,10014995 ! organelle localization GO:0051640 96 62 1,000 0,04907348 0,10006116 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,05033043 0,10253321 ! regulation of developmental growth GO:0048638 13 9 0,000 0,05033043 0,10244248 ! telencephalon cell migration GO:0022029 16 9 0,000 0,05033043 0,1023519 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,05033043 0,10226148 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05033043 0,10217123 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05033043 0,10208113 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,05033043 0,10199119 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05033043 0,10190141 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05033043 0,10181178 ! GTP metabolic process GO:0046039 9 9 0,000 0,05033043 0,10172232 ! elastic fiber assembly GO:0048251 13 9 0,000 0,05033043 0,10163301 ! social behavior GO:0035176 14 9 0,000 0,05033043 0,10154386 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,05033043 0,10145486 ! artery development GO:0060840 19 9 0,000 0,05033043 0,10136602 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05033043 0,10127734 ! response to pain GO:0048265 16 9 0,000 0,05033043 0,10118881 ! protein complex disassembly GO:0043241 17 9 0,000 0,05033043 0,10110044 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,05033043 0,10101221 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,05033043 0,10092415 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05033043 0,10083624 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05033043 0,10074848 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,05033043 0,10066087 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05033043 0,10057341 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05033043 0,10048611 ! ventral spinal cord development GO:0021517 11 9 0,000 0,05033043 0,10039896 ! protein targeting to ER GO:0045047 19 9 0,000 0,05033043 0,10031196 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05033043 0,10022511 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05033043 0,10013841 ! arginine catabolic process GO:0006527 10 9 0,000 0,05033043 0,10005186 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05033043 0,09996546 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05033043 0,0998792 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,05033043 0,0997931 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05033043 0,09970715 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,05033043 0,09962134 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,05033043 0,09953568 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05033043 0,09945017 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05033043 0,09936481 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05033043 0,09927959 ! mannose metabolic process GO:0006013 9 9 0,000 0,05033043 0,09919451 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,05033043 0,09910959 ! receptor clustering GO:0043113 15 9 0,000 0,05033043 0,09902481 ! epithelial cell development GO:0002064 10 9 0,000 0,05033043 0,09894017 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05033043 0,09885568 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05033043 0,09877133 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05033043 0,09868713 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05033043 0,09860307 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05033043 0,09851915 ! motor axon guidance GO:0008045 14 9 0,000 0,05033043 0,09843537 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,05033043 0,09835174 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,05033043 0,09826825 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05033043 0,0981849 ! DNA ligation GO:0006266 14 9 0,000 0,05033043 0,09810169 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,05033043 0,09801863 ! response to amine stimulus GO:0014075 13 9 0,000 0,05033043 0,0979357 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05033043 0,09785291 ! erythrocyte development GO:0048821 11 9 0,000 0,05033043 0,09777027 ! renal water homeostasis GO:0003091 14 9 0,000 0,05033043 0,09768776 ! postreplication repair GO:0006301 11 9 0,000 0,05033043 0,09760539 ! mRNA cleavage GO:0006379 13 9 0,000 0,05033043 0,09752317 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05033043 0,09744108 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,05033043 0,09735912 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05033043 0,09727731 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,05033043 0,09719563 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05033043 0,09711409 ! acid secretion GO:0046717 14 9 0,000 0,05033043 0,09703269 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05033043 0,09695142 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05033043 0,09687029 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,05033043 0,0967893 ! purine base metabolic process GO:0006144 18 9 0,000 0,05033043 0,09670844 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05033043 0,09662771 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,05033043 0,09654712 ! detection of calcium ion GO:0005513 13 9 0,000 0,05033043 0,09646667 ! blastocyst formation GO:0001825 12 9 0,000 0,05033043 0,09638634 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05033043 0,09630616 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05033043 0,0962261 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05033043 0,09614618 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,05033043 0,09606639 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05033043 0,09598673 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05033043 0,09590721 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05033043 0,09582781 ! prepulse inhibition GO:0060134 14 9 0,000 0,05033043 0,09574855 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,05033043 0,09566942 ! insulin secretion GO:0030073 17 9 0,000 0,05033043 0,09559042 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05033043 0,09551155 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05033043 0,09543281 ! nucleus localization GO:0051647 15 9 0,000 0,05033043 0,0953542 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05033043 0,09527572 ! localization within membrane GO:0051668 15 9 0,000 0,05033043 0,09519737 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,050498 0,09543583 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,050498 0,09535747 ! viral reproduction GO:0016032 92 63 1,000 0,050498 0,09527925 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,05193736 0,09791469 ! adaptive immune response GO:0002250 94 64 1,000 0,05193736 0,0978345 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 1,000 0,05339133 0,10049105 ! protein oligomerization GO:0051259 100 65 1,000 0,05339133 0,10040889 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,05485972 0,10308608 ! axon guidance GO:0007411 99 66 1,000 0,05485972 0,10300192 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,05485972 0,10291791 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,0557655 0,10453191 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,0557655 0,10444679 ! neuron fate specification GO:0048665 11 10 0,000 0,0557655 0,1043618 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,0557655 0,10427696 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,0557655 0,10419225 ! thyroid gland development GO:0030878 19 10 0,000 0,0557655 0,10410768 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,0557655 0,10402324 ! synapsis GO:0007129 13 10 0,000 0,0557655 0,10393894 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,0557655 0,10385478 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,0557655 0,10377076 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,0557655 0,10368687 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,0557655 0,10360312 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,0557655 0,1035195 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,0557655 0,10343601 ! androgen metabolic process GO:0008209 13 10 0,000 0,0557655 0,10335266 ! phospholipid efflux GO:0033700 16 10 0,000 0,0557655 0,10326945 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,0557655 0,10318637 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,0557655 0,10310342 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,0557655 0,10302061 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,0557655 0,10293793 ! pathogenesis GO:0009405 13 10 0,000 0,0557655 0,10285538 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,0557655 0,10277296 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0557655 0,10269068 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,0557655 0,10260853 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,0557655 0,1025265 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,0557655 0,10244461 ! melanocyte differentiation GO:0030318 15 10 0,000 0,0557655 0,10236285 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,0557655 0,10228123 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,0557655 0,10219973 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,0557655 0,10211836 ! response to X-ray GO:0010165 16 10 0,000 0,0557655 0,10203712 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,0557655 0,10195601 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,0557655 0,10187503 ! forebrain cell migration GO:0021885 17 10 0,000 0,0557655 0,10179417 ! lipid digestion GO:0044241 15 10 0,000 0,0557655 0,10171345 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,0557655 0,10163285 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,0557655 0,10155238 ! UV protection GO:0009650 14 10 0,000 0,0557655 0,10147204 ! entry into host cell GO:0030260 20 10 0,000 0,0557655 0,10139182 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,0557655 0,10131174 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,0557655 0,10123177 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,0557655 0,10115194 ! regulation of organ growth GO:0046620 11 10 0,000 0,0557655 0,10107223 ! response to dsRNA GO:0043331 18 10 0,000 0,0557655 0,10099264 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,0557655 0,10091318 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,0557655 0,10083385 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,0557655 0,10075464 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,0557655 0,10067555 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,0557655 0,10059659 ! cranial nerve development GO:0021545 12 10 0,000 0,0557655 0,10051776 ! fucose catabolic process GO:0019317 16 10 0,000 0,0557655 0,10043904 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,0557655 0,10036045 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,0557655 0,10028198 ! protein sumoylation GO:0016925 12 10 0,000 0,0557655 0,10020364 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,0557655 0,10012541 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0557655 0,10004731 ! zymogen activation GO:0031638 14 10 0,000 0,0557655 0,09996933 ! salivary gland development GO:0007431 22 10 0,000 0,0557655 0,09989148 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,0557655 0,09981374 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,0557655 0,09973612 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,0557655 0,09965863 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,0557655 0,09958126 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,0557655 0,099504 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,0557655 0,09942687 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,0557655 0,09934985 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,0557655 0,09927295 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,0557655 0,09919618 ! embryonic gut development GO:0048566 11 10 0,000 0,0557655 0,09911952 ! activation of innate immune response GO:0002218 10 10 0,000 0,0557655 0,09904298 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,0557655 0,09896656 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,0557655 0,09889025 ! developmental induction GO:0031128 13 10 0,000 0,0557655 0,09881407 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,0557655 0,098738 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,0557655 0,09866204 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,0557655 0,09858621 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,0557655 0,09851049 ! response to drug GO:0042493 108 69 1,000 0,05934926 0,10476078 ! response to metal ion GO:0010038 103 70 1,000 0,06087322 0,1073684 ! humoral immune response GO:0006959 86 70 1,000 0,06087322 0,10728613 ! eye development GO:0001654 111 70 1,000 0,06087322 0,10720398 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,06087322 0,10712196 ! regulation of catabolic process GO:0009894 106 70 1,000 0,06087322 0,10704006 ! rRNA transcription GO:0009303 17 11 0,000 0,06116978 0,10747936 ! respiratory burst GO:0045730 14 11 0,000 0,06116978 0,10739732 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,06116978 0,1073154 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,06116978 0,1072336 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,06116978 0,10715193 ! virus-host interaction GO:0019048 17 11 0,000 0,06116978 0,10707038 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,06116978 0,10698896 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,06116978 0,10690766 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,06116978 0,10682649 ! RNA polyadenylation GO:0043631 19 11 0,000 0,06116978 0,10674544 ! mating GO:0007618 14 11 0,000 0,06116978 0,10666451 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,06116978 0,1065837 ! T cell proliferation GO:0042098 20 11 0,000 0,06116978 0,10650302 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,06116978 0,10642245 ! bone resorption GO:0045453 16 11 0,000 0,06116978 0,10634201 ! regulated secretory pathway GO:0045055 14 11 0,000 0,06116978 0,10626169 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,06116978 0,1061815 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,06116978 0,10610142 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,06116978 0,10602146 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,06116978 0,10594163 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,06116978 0,10586191 ! syncytium formation GO:0006949 15 11 0,000 0,06116978 0,10578232 ! plasma membrane organization GO:0007009 18 11 0,000 0,06116978 0,10570284 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,06116978 0,10562349 ! mitotic spindle organization GO:0007052 15 11 0,000 0,06116978 0,10554425 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,06116978 0,10546513 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,06116978 0,10538613 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,06116978 0,10530725 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,06116978 0,10522848 ! adult heart development GO:0007512 11 11 0,000 0,06116978 0,10514984 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,06116978 0,10507131 ! temperature homeostasis GO:0001659 16 11 0,000 0,06116978 0,1049929 ! L-glutamate transport GO:0015813 16 11 0,000 0,06116978 0,1049146 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,06116978 0,10483643 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,06116978 0,10475836 ! protein homotetramerization GO:0051289 18 11 0,000 0,06116978 0,10468042 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,06116978 0,10460259 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,06116978 0,10452488 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,06116978 0,10444728 ! vasoconstriction GO:0042310 15 11 0,000 0,06116978 0,10436979 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,06116978 0,10429243 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,06116978 0,10421517 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,06116978 0,10413803 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,06116978 0,10406101 ! ribosome assembly GO:0042255 13 11 0,000 0,06116978 0,1039841 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,06116978 0,1039073 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,06116978 0,10383062 ! chromatin silencing GO:0006342 19 11 0,000 0,06116978 0,10375404 ! nucleosome positioning GO:0016584 13 11 0,000 0,06116978 0,10367759 ! regulation of isotype switching GO:0045191 19 11 0,000 0,06116978 0,10360124 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,06116978 0,10352501 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,06116978 0,10344888 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,06116978 0,10337288 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,06116978 0,10329698 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,06116978 0,10322119 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,06116978 0,10314552 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,06116978 0,10306995 ! male genitalia development GO:0030539 13 11 0,000 0,06116978 0,1029945 ! cholesterol efflux GO:0033344 19 11 0,000 0,06116978 0,10291915 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,06116978 0,10284392 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,06116978 0,1027688 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,06116978 0,10269378 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,06116978 0,10261888 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,06116978 0,10254408 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,06116978 0,1024694 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,06116978 0,10239482 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,06116978 0,10232035 ! lysogeny GO:0030069 18 11 0,000 0,06116978 0,10224599 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,06116978 0,10217174 ! acrosome reaction GO:0007340 13 11 0,000 0,06116978 0,10209759 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,06116978 0,10202356 ! muscle cell differentiation GO:0042692 104 71 1,000 0,06241056 0,1040176 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,06241056 0,10394227 ! tube morphogenesis GO:0035239 118 73 1,000 0,0655246 0,10904962 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,0655246 0,10897077 ! lactation GO:0007595 20 12 0,000 0,06654342 0,11058517 ! reproductive cellular process GO:0048610 14 12 0,000 0,06654342 0,11050533 ! tRNA modification GO:0006400 14 12 0,000 0,06654342 0,1104256 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,06654342 0,11034598 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,06654342 0,11026648 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,06654342 0,1101871 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,06654342 0,11010782 ! non-recombinational repair GO:0000726 19 12 0,000 0,06654342 0,11002867 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,06654342 0,10994962 ! peroxisomal transport GO:0043574 21 12 0,000 0,06654342 0,10987069 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,06654342 0,10979188 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,06654342 0,10971317 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,06654342 0,10963458 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,06654342 0,1095561 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,06654342 0,10947774 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,06654342 0,10939948 ! arginine metabolic process GO:0006525 13 12 0,000 0,06654342 0,10932134 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,06654342 0,10924331 ! methionine metabolic process GO:0006555 13 12 0,000 0,06654342 0,10916539 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,06654342 0,10908758 ! Golgi organization GO:0007030 18 12 0,000 0,06654342 0,10900988 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,06654342 0,1089323 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,06654342 0,10885482 ! monoamine transport GO:0015844 13 12 0,000 0,06654342 0,10877745 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06654342 0,1087002 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,06654342 0,10862305 ! L-amino acid transport GO:0015807 20 12 0,000 0,06654342 0,10854601 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,06654342 0,10846908 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,06654342 0,10839226 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,06654342 0,10831555 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06654342 0,10823895 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,06654342 0,10816246 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,06654342 0,10808607 ! cerebellum development GO:0021549 13 12 0,000 0,06654342 0,10800979 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,06654342 0,10793362 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,06654342 0,10785756 ! histone methylation GO:0016571 15 12 0,000 0,06654342 0,1077816 ! autonomic nervous system development GO:0048483 23 12 0,000 0,06654342 0,10770575 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,06654342 0,10763001 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,06654342 0,10755438 ! regulation of epidermis development GO:0045682 17 12 0,000 0,06654342 0,10747885 ! intestinal absorption GO:0050892 19 12 0,000 0,06654342 0,10740342 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,06654342 0,1073281 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,06654342 0,10725289 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,06654342 0,10717778 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,06654342 0,10710278 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,06654342 0,10702789 ! microspike assembly GO:0030035 23 12 0,000 0,06654342 0,10695309 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,06654342 0,10687841 ! response to cold GO:0009409 14 12 0,000 0,06654342 0,10680382 ! protein import into nucleus GO:0006606 118 74 1,000 0,0671009 0,10762349 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,0671009 0,10754849 ! blood coagulation GO:0007596 116 75 1,000 0,06868981 0,11001849 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,06868981 0,10994193 ! nuclear import GO:0051170 121 75 1,000 0,06868981 0,10986548 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,07029112 0,11234855 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,07188662 0,11481891 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,07188662 0,11473923 ! cGMP metabolic process GO:0046068 16 13 0,000 0,07188662 0,11465966 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,07188662 0,1145802 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,07188662 0,11450085 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,07188662 0,11442161 ! lipid localization GO:0010876 24 13 0,000 0,07188662 0,11434248 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,07188662 0,11426346 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,07188662 0,11418455 ! organelle fusion GO:0048284 28 13 0,000 0,07188662 0,11410575 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,07188662 0,11402706 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,07188662 0,11394847 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,07188662 0,11386999 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,07188662 0,11379162 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,07188662 0,11371336 ! response to hexose stimulus GO:0009746 19 13 0,000 0,07188662 0,11363521 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,07188662 0,11355716 ! glutamate metabolic process GO:0006536 18 13 0,000 0,07188662 0,11347922 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,07188662 0,11340139 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,07188662 0,11332367 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,07188662 0,11324605 ! NAD metabolic process GO:0019674 21 13 0,000 0,07188662 0,11316854 ! exocrine system development GO:0035272 27 13 0,000 0,07188662 0,11309113 ! bone mineralization GO:0030282 15 13 0,000 0,07188662 0,11301383 ! regulation of exocytosis GO:0017157 17 13 0,000 0,07188662 0,11293663 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,07188662 0,11285954 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,07188662 0,11278256 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,07188662 0,11270568 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,07188662 0,1126289 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,07188662 0,11255223 ! genitalia development GO:0048806 15 13 0,000 0,07188662 0,11247567 ! regulation of cellular pH GO:0030641 20 13 0,000 0,07188662 0,1123992 ! tissue regeneration GO:0042246 21 13 0,000 0,07188662 0,11232285 ! cofactor transport GO:0051181 19 13 0,000 0,07188662 0,11224659 ! NADP metabolic process GO:0006739 18 13 0,000 0,07188662 0,11217044 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,07188662 0,11209439 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,07188662 0,11201845 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07188662 0,11194261 ! gas transport GO:0015669 18 13 0,000 0,07188662 0,11186687 ! heme biosynthetic process GO:0006783 20 13 0,000 0,07188662 0,11179123 ! regulation of axon extension GO:0030516 23 13 0,000 0,07188662 0,1117157 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,07188662 0,11164026 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,07188662 0,11156493 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,07188662 0,1114897 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,07188662 0,11141458 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,07188662 0,11133955 ! gland development GO:0048732 148 77 1,000 0,07190464 0,11129251 ! protein ubiquitination GO:0016567 125 77 1,000 0,07190464 0,11121767 ! T cell activation GO:0042110 134 79 1,000 0,07516758 0,11618644 ! protein localization in nucleus GO:0034504 133 80 1,000 0,07681662 0,11865563 ! forebrain development GO:0030900 131 80 1,000 0,07681662 0,11857599 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,07719954 0,11908715 ! superoxide anion generation GO:0042554 18 14 0,000 0,07719954 0,11900733 ! neuron maturation GO:0042551 21 14 0,000 0,07719954 0,11892762 ! regulation of S phase GO:0033261 18 14 0,000 0,07719954 0,11884802 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,07719954 0,11876852 ! myotube differentiation GO:0014902 21 14 0,000 0,07719954 0,11868913 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,07719954 0,11860984 ! inositol metabolic process GO:0006020 20 14 0,000 0,07719954 0,11853067 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,07719954 0,11845159 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,07719954 0,11837263 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,07719954 0,11829376 ! gene silencing by RNA GO:0031047 20 14 0,000 0,07719954 0,11821501 ! response to cAMP GO:0051591 19 14 0,000 0,07719954 0,11813635 ! startle response GO:0001964 21 14 0,000 0,07719954 0,1180578 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,07719954 0,11797936 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,07719954 0,11790102 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,07719954 0,11782279 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,07719954 0,11774465 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,07719954 0,11766663 ! glycine metabolic process GO:0006544 22 14 0,000 0,07719954 0,1175887 ! pituitary gland development GO:0021983 23 14 0,000 0,07719954 0,11751088 ! cellular response to starvation GO:0009267 21 14 0,000 0,07719954 0,11743316 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,07719954 0,11735554 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,07719954 0,11727803 ! regulation of heart rate GO:0002027 23 14 0,000 0,07719954 0,11720062 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,07719954 0,11712331 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,07719954 0,1170461 ! embryo implantation GO:0007566 27 14 0,000 0,07719954 0,116969 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,07719954 0,11689199 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,07719954 0,11681509 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,07719954 0,11673829 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,07719954 0,11666159 ! axon cargo transport GO:0008088 27 14 0,000 0,07719954 0,11658499 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,07719954 0,11650849 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,07719954 0,11643209 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07719954 0,11635579 ! mRNA splice site selection GO:0006376 26 14 0,000 0,07719954 0,11627959 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,07719954 0,11620349 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,07719954 0,11612749 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,07719954 0,11605159 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,07719954 0,11597579 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,07719954 0,11590009 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,07719954 0,11582449 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,07719954 0,11574898 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,07719954 0,11567358 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,07719954 0,11559827 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,07719954 0,11552306 ! cell killing GO:0001906 20 14 0,000 0,07719954 0,11544794 ! cilium assembly GO:0042384 20 14 0,000 0,07719954 0,11537293 ! peptide hormone secretion GO:0030072 23 14 0,000 0,07719954 0,11529801 ! hemostasis GO:0007599 125 81 1,000 0,07847713 0,11713005 ! response to protein stimulus GO:0051789 111 81 1,000 0,07847713 0,11705409 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,07847713 0,11697823 GO:0002696|positive regulation of leukocyte activation, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,08183184 0,12189976 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,08248234 0,12278925 ! positive regulation of cell size GO:0045793 20 15 0,000 0,08248234 0,12270983 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,08248234 0,1226305 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,08248234 0,12255129 ! skin development GO:0043588 25 15 0,000 0,08248234 0,12247217 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,08248234 0,12239316 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,08248234 0,12231424 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,08248234 0,12223543 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,08248234 0,12215672 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,08248234 0,12207811 ! bile acid metabolic process GO:0008206 22 15 0,000 0,08248234 0,12199961 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,08248234 0,1219212 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,08248234 0,1218429 ! adult walking behavior GO:0007628 25 15 0,000 0,08248234 0,12176469 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,08248234 0,12168659 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,08248234 0,12160858 ! centrosome cycle GO:0007098 16 15 0,000 0,08248234 0,12153068 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,08248234 0,12145287 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,08248234 0,12137517 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,08248234 0,12129756 ! cerebral cortex development GO:0021987 29 15 0,000 0,08248234 0,12122006 ! response to osmotic stress GO:0006970 22 15 0,000 0,08248234 0,12114265 ! vesicle coating GO:0006901 25 15 0,000 0,08248234 0,12106534 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,08248234 0,12098813 ! DNA integration GO:0015074 22 15 0,000 0,08248234 0,12091102 ! peptide secretion GO:0002790 27 15 0,000 0,08248234 0,12083401 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,08248234 0,12075709 ! regulation of vasodilation GO:0042312 24 15 0,000 0,08248234 0,12068027 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,08248234 0,12060355 ! neuron recognition GO:0008038 22 15 0,000 0,08248234 0,12052693 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,08248234 0,12045041 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,08248234 0,12037398 ! biomineral formation GO:0031214 18 15 0,000 0,08248234 0,12029765 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,08248234 0,12022141 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,08248234 0,12014528 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,08248234 0,12006923 ! dopamine metabolic process GO:0042417 30 15 0,000 0,08248234 0,11999329 ! organic cation transport GO:0015695 19 15 0,000 0,08248234 0,11991744 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,08248234 0,11984169 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,08248234 0,11976603 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,08248234 0,11969047 ! peptide hormone processing GO:0016486 19 15 0,000 0,08248234 0,119615 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,08248234 0,11953963 ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,08523026 0,12344433 ! regulation of membrane potential GO:0042391 128 85 1,000 0,08523026 0,12336665 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,08523026 0,12328906 ! protein secretion GO:0009306 27 16 0,000 0,08773521 0,12683279 ! hormone secretion GO:0046879 25 16 0,000 0,08773521 0,12675313 ! bone remodeling GO:0046849 24 16 0,000 0,08773521 0,12667356 ! endothelial cell migration GO:0043542 22 16 0,000 0,08773521 0,12659409 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,08773521 0,12651472 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08773521 0,12643545 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,08773521 0,12635628 ! glial cell development GO:0021782 24 16 0,000 0,08773521 0,12627721 ! patterning of blood vessels GO:0001569 24 16 0,000 0,08773521 0,12619823 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,08773521 0,12611936 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,08773521 0,12604058 ! protein polyubiquitination GO:0000209 26 16 0,000 0,08773521 0,12596191 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,08773521 0,12588333 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,08773521 0,12580485 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,08773521 0,12572647 ! fructose metabolic process GO:0006000 20 16 0,000 0,08773521 0,12564818 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,08773521 0,12556999 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,08773521 0,1254919 ! protein export from nucleus GO:0006611 24 16 0,000 0,08773521 0,12541391 ! negative regulation of immune response GO:0050777 28 16 0,000 0,08773521 0,12533601 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,08773521 0,12525821 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,08773521 0,12518051 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,08773521 0,1251029 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,08773521 0,12502539 ! diencephalon development GO:0021536 25 16 0,000 0,08773521 0,12494797 ! G1 phase GO:0051318 27 16 0,000 0,08773521 0,12487065 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,08773521 0,12479343 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,08773521 0,1247163 GO:0006626|protein targeting to mitochondrion, ! steroid catabolic process GO:0006706 22 16 0,000 0,08773521 0,12463927 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,08773521 0,12456233 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,08773521 0,12448549 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,08773521 0,12440874 ! sperm-egg recognition GO:0035036 16 16 0,000 0,08773521 0,12433209 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,08773521 0,12425553 ! nerve development GO:0021675 18 16 0,000 0,08773521 0,12417906 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,08773521 0,12410269 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,08773521 0,12402641 ! negative regulation of translation GO:0017148 22 16 0,000 0,08773521 0,12395023 ! female pregnancy GO:0007565 130 87 1,000 0,08867099 0,12519538 ! protein processing GO:0016485 114 88 1,000 0,09040679 0,12756786 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,0929583 0,13108773 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,0929583 0,1310074 ! negative regulation of defense response GO:0031348 19 17 0,000 0,0929583 0,13092718 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,0929583 0,13084705 ! glycerol metabolic process GO:0006071 20 17 0,000 0,0929583 0,13076702 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,0929583 0,13068709 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,0929583 0,13060726 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,0929583 0,13052752 ! signal complex assembly GO:0007172 29 17 0,000 0,0929583 0,13044788 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,0929583 0,13036834 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,0929583 0,1302889 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,0929583 0,13020955 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,0929583 0,1301303 ! memory GO:0007613 25 17 0,000 0,0929583 0,13005114 ! keratinization GO:0031424 17 17 0,000 0,0929583 0,12997209 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,0929583 0,12989312 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,0929583 0,12981426 ! retinoid metabolic process GO:0001523 22 17 0,000 0,0929583 0,12973549 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,0929583 0,12965681 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,0929583 0,12957823 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,0929583 0,12949975 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,0929583 0,12942136 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,0929583 0,12934306 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,0929583 0,12926486 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,0929583 0,12918676 ! membrane budding GO:0006900 29 17 0,000 0,0929583 0,12910875 ! heme metabolic process GO:0042168 27 17 0,000 0,0929583 0,12903083 ! neuromuscular junction development GO:0007528 23 17 0,000 0,0929583 0,128953 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,0929583 0,12887528 ! body fluid secretion GO:0007589 27 17 0,000 0,0929583 0,12879764 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,0929583 0,1287201 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,0929583 0,12864265 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,0929583 0,12856529 ! sensory perception of pain GO:0019233 23 17 0,000 0,0929583 0,12848803 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,0929583 0,12841086 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,0929583 0,12833378 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,0929583 0,1282568 ! synaptogenesis GO:0007416 24 17 0,000 0,0929583 0,12817991 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,0929583 0,1281031 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,0929583 0,1280264 ! cell-cell junction organization GO:0045216 25 17 0,000 0,0929583 0,12794978 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,0929583 0,12787325 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,0929583 0,12779682 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,0929583 0,12772048 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,0929583 0,12764423 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,0929583 0,12756807 ! leukocyte differentiation GO:0002521 143 90 1,000 0,09390839 0,12879505 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,09390839 0,12871829 ! response to virus GO:0009615 122 91 1,000 0,09567386 0,13106008 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,09744888 0,13341216 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,09815178 0,13429452 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,09815178 0,13421468 ! positive regulation of translation GO:0045727 28 18 0,000 0,09815178 0,13413493 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,09815178 0,13405528 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,09815178 0,13397572 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,09815178 0,13389626 ! cAMP metabolic process GO:0046058 33 18 0,000 0,09815178 0,13381689 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,09815178 0,13373761 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,09815178 0,13365843 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,09815178 0,13357934 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,09815178 0,13350035 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,09815178 0,13342145 ! glutamine metabolic process GO:0006541 23 18 0,000 0,09815178 0,13334264 ! central nervous system neuron development GO:0021954 30 18 0,000 0,09815178 0,13326393 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,09815178 0,1331853 ! fucose metabolic process GO:0006004 26 18 0,000 0,09815178 0,13310678 ! response to fungus GO:0009620 19 18 0,000 0,09815178 0,13302834 ! peptide cross-linking GO:0018149 31 18 0,000 0,09815178 0,13295 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,09815178 0,13287174 ! heart process GO:0003015 27 18 0,000 0,09815178 0,13279358 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,09815178 0,13271552 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,09815178 0,13263754 ! visual learning GO:0008542 35 18 0,000 0,09815178 0,13255965 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,09815178 0,13248186 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,09815178 0,13240416 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,09815178 0,13232655 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,09815178 0,13224903 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,09815178 0,1321716 ! vitamin transport GO:0051180 24 18 0,000 0,09815178 0,13209426 ! hormone transport GO:0009914 27 18 0,000 0,09815178 0,13201701 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,09815178 0,13193985 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,09815178 0,13186279 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,09815178 0,13178581 ! cell-cell recognition GO:0009988 20 18 0,000 0,09815178 0,13170892 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,09815178 0,13163212 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,09815178 0,13155541 ! regulation of glucose import GO:0046324 21 18 0,000 0,09815178 0,1314788 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,09815178 0,13140227 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,09815178 0,13132582 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,0992333 0,1326957 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,10331582 0,1380746 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,10331582 0,13799442 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,10331582 0,13791433 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,10331582 0,13783433 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,10331582 0,13775443 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,10331582 0,13767462 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,10331582 0,1375949 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,10331582 0,13751527 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,10331582 0,13743574 ! sensory perception of taste GO:0050909 23 19 0,000 0,10331582 0,13735629 ! smooth muscle contraction GO:0006939 36 19 0,000 0,10331582 0,13727694 ! peroxisome organization GO:0007031 29 19 0,000 0,10331582 0,13719768 ! digestive system process GO:0022600 30 19 0,000 0,10331582 0,13711852 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,10331582 0,13703944 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,10331582 0,13696045 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,10331582 0,13688156 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,10331582 0,13680276 ! response to starvation GO:0042594 30 19 0,000 0,10331582 0,13672404 ! sex determination GO:0007530 29 19 0,000 0,10331582 0,13664542 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,10331582 0,13656689 ! cytolysis GO:0019835 20 19 0,000 0,10331582 0,13648845 ! vasodilation GO:0042311 33 19 0,000 0,10331582 0,1364101 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,10331582 0,13633183 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,10331582 0,13625366 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,10331582 0,13617558 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,10331582 0,13609759 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,10331582 0,13601968 ! sarcomere organization GO:0045214 23 19 0,000 0,10331582 0,13594187 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,10331582 0,13586414 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,10331582 0,13578651 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,10331582 0,13570896 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,10331582 0,1356315 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,10331582 0,13555413 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,10331582 0,13547685 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,10331582 0,13539965 ! protein stabilization GO:0050821 26 19 0,000 0,10331582 0,13532254 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,1046413 0,13698064 ! in utero embryonic development GO:0001701 147 96 1,000 0,1046413 0,13690272 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,1046413 0,13682489 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,1046413 0,13674715 ! protein maturation GO:0051604 129 96 1,000 0,1046413 0,1366695 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,10845059 0,14156433 ! iron ion transport GO:0006826 37 20 0,000 0,10845059 0,14148403 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,10845059 0,14140383 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,10845059 0,14132371 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,10845059 0,14124369 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,10845059 0,14116375 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,10845059 0,14108391 ! spinal cord development GO:0021510 31 20 0,000 0,10845059 0,14100415 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,10845059 0,14092449 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,10845059 0,14084492 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,10845059 0,14076543 ! chromosome condensation GO:0030261 31 20 0,000 0,10845059 0,14068604 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,10845059 0,14060674 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,10845059 0,14052752 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,10845059 0,14044839 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,10845059 0,14036936 ! DNA modification GO:0006304 28 20 0,000 0,10845059 0,14029041 ! collagen fibril organization GO:0030199 45 20 0,000 0,10845059 0,14021155 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,10845059 0,14013278 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,10845059 0,1400541 ! collagen catabolic process GO:0030574 25 20 0,000 0,10845059 0,1399755 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,10845059 0,139897 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,10845059 0,13981858 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,10845059 0,13974025 ! alditol metabolic process GO:0019400 24 20 0,000 0,10845059 0,13966201 ! actin filament-based movement GO:0030048 34 20 0,000 0,10845059 0,13958386 ! protein import GO:0017038 156 99 1,000 0,11012806 0,14166361 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,11012806 0,14158442 ! regulation of translation GO:0006417 151 100 1,000 0,11197375 0,14387689 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,11197375 0,14379655 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,11197375 0,14371631 ! protein localization in organelle GO:0033365 161 100 1,000 0,11197375 0,14363616 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,11355624 0,14558492 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,11355624 0,14550382 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,11355624 0,1454228 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,11355624 0,14534188 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,11355624 0,14526104 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,11355624 0,1451803 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,11355624 0,14509964 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,11355624 0,14501908 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,11355624 0,1449386 ! vesicle docking GO:0048278 27 21 0,000 0,11355624 0,14485821 ! phototransduction GO:0007602 25 21 0,000 0,11355624 0,14477791 ! dendrite development GO:0016358 35 21 0,000 0,11355624 0,1446977 ! visual behavior GO:0007632 39 21 0,000 0,11355624 0,14461758 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,11355624 0,14453755 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,11355624 0,14445761 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,11355624 0,14437775 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,11355624 0,14429799 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,11355624 0,14421831 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,11355624 0,14413872 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,11355624 0,14405921 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,11355624 0,1439798 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,11355624 0,14390047 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,11355624 0,14382123 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,11355624 0,14374208 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,11355624 0,14366301 ! fatty acid transport GO:0015908 30 21 0,000 0,11355624 0,14358403 ! immunoglobulin production GO:0002377 33 21 0,000 0,11355624 0,14350514 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,11355624 0,14342633 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,11355624 0,14334762 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,11355624 0,14326898 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,11355624 0,14319044 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,11355624 0,14311198 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,11355624 0,1430336 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,11355624 0,14295531 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,11355624 0,14287711 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,11355624 0,14279899 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,11355624 0,14272096 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,11355624 0,14264301 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,11863295 0,14893874 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,11863295 0,14885749 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,11863295 0,14877632 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,11863295 0,14869525 ! leukocyte adhesion GO:0007159 38 22 0,000 0,11863295 0,14861426 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,11863295 0,14853336 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,11863295 0,14845255 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,11863295 0,14837182 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,11863295 0,14829118 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,11863295 0,14821064 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,11863295 0,14813017 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,11863295 0,1480498 ! lysosome organization GO:0007040 37 22 0,000 0,11863295 0,14796951 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,11863295 0,14788931 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,11863295 0,1478092 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,11863295 0,14772917 ! membrane depolarization GO:0051899 35 22 0,000 0,11863295 0,14764923 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,11863295 0,14756938 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,11863295 0,14748961 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,11863295 0,14740993 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,11863295 0,14733033 ! blastocyst development GO:0001824 37 22 0,000 0,11863295 0,14725083 ! neural tube closure GO:0001843 33 22 0,000 0,11863295 0,1471714 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,11863295 0,14709206 ! protein tetramerization GO:0051262 39 22 0,000 0,11863295 0,14701281 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,12368087 0,15318578 ! neuron fate commitment GO:0048663 32 23 0,000 0,12368087 0,15310334 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,12368087 0,15302098 ! myelination GO:0042552 35 23 0,000 0,12368087 0,15293871 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,12368087 0,15285653 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,12368087 0,15277444 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,12368087 0,15269243 ! vesicle targeting GO:0006903 32 23 0,000 0,12368087 0,15261051 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,12368087 0,15252869 ! interaction with host GO:0051701 37 23 0,000 0,12368087 0,15244694 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,12368087 0,15236529 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,12368087 0,15228373 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,12368087 0,15220225 ! cell fate determination GO:0001709 45 23 0,000 0,12368087 0,15212086 ! pentose metabolic process GO:0019321 31 23 0,000 0,12368087 0,15203955 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,12368087 0,15195833 ! spermatid development GO:0007286 33 23 0,000 0,12368087 0,1518772 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,12368087 0,15179616 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,12368087 0,1517152 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,12368087 0,15163433 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,12368087 0,15155354 ! telomere organization GO:0032200 32 23 0,000 0,12368087 0,15147284 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,12368087 0,15139223 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,12368087 0,1513117 ! regulation of amine transport GO:0051952 38 23 0,000 0,12368087 0,15123126 ! liver development GO:0001889 40 23 0,000 0,12368087 0,1511509 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,12870017 0,15720148 ! initiation of viral infection GO:0019059 42 24 0,000 0,12870017 0,15711804 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,12870017 0,15703469 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,12870017 0,15695142 ! superoxide metabolic process GO:0006801 32 24 0,000 0,12870017 0,15686825 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,12870017 0,15678516 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,12870017 0,15670216 ! sperm motility GO:0030317 27 24 0,000 0,12870017 0,15661925 ! vacuole organization GO:0007033 39 24 0,000 0,12870017 0,15653643 ! receptor metabolic process GO:0043112 37 24 0,000 0,12870017 0,15645369 ! primary neural tube formation GO:0014020 35 24 0,000 0,12870017 0,15637104 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,12870017 0,15628848 ! base-excision repair GO:0006284 31 24 0,000 0,12870017 0,15620601 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,12870017 0,15612362 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,12870017 0,15604132 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,12870017 0,15595911 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,12870017 0,15587698 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,133691 0,16183647 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,133691 0,16175134 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,133691 0,1616663 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,133691 0,16158135 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,133691 0,16149648 ! peptide transport GO:0015833 43 25 0,000 0,133691 0,16141171 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,133691 0,16132702 ! phospholipid transport GO:0015914 35 25 0,000 0,133691 0,16124242 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,133691 0,16115791 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,133691 0,16107349 ! detection of light stimulus GO:0009583 30 25 0,000 0,133691 0,16098916 ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,133691 0,16090492 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,13865353 0,16679034 ! translational initiation GO:0006413 43 26 0,000 0,13865353 0,16670315 ! regulation of pH GO:0006885 36 26 0,000 0,13865353 0,16661605 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,13865353 0,16652905 ! circadian rhythm GO:0007623 42 26 0,000 0,13865353 0,16644213 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,13865353 0,16635531 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,13865353 0,16626857 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,13865353 0,16618193 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,13865353 0,16609538 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,13865353 0,16600891 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,13865353 0,16592254 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,13865353 0,16583626 ! regulation of coagulation GO:0050818 39 26 0,000 0,13865353 0,16575006 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,14358792 0,17155959 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,14358792 0,17147051 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,14358792 0,17138153 ! membrane docking GO:0022406 39 27 0,000 0,14358792 0,17129264 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,14358792 0,17120384 ! catechol metabolic process GO:0009712 43 27 0,000 0,14358792 0,17111514 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,14358792 0,17102652 ! acute-phase response GO:0006953 42 27 0,000 0,14358792 0,170938 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,14358792 0,17084957 ! myofibril assembly GO:0030239 36 27 0,000 0,14358792 0,17076123 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,14358792 0,17067298 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,14358792 0,17058482 ! natural killer cell activation GO:0030101 35 27 0,000 0,14358792 0,17049675 ! lipid oxidation GO:0034440 38 27 0,000 0,14358792 0,17040878 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,14358792 0,17032089 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,14358792 0,1702331 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,14358792 0,17014539 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,14358792 0,17005778 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,14358792 0,16997026 ! gene silencing GO:0016458 41 27 0,000 0,14358792 0,16988282 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,14849432 0,17559739 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,14849432 0,17550716 ! phenol metabolic process GO:0018958 44 28 0,000 0,14849432 0,17541702 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,14849432 0,17532697 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,14849432 0,17523701 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,14849432 0,17514714 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,14849432 0,17505737 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,14849432 0,17496769 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,14849432 0,1748781 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,14849432 0,1747886 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,14849432 0,1746992 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,14849432 0,17460988 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,14849432 0,17452066 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,14849432 0,17443153 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,14849432 0,17434249 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,14849432 0,17425354 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,14849432 0,17416468 ! ensheathment of neurons GO:0007272 43 28 0,000 0,14849432 0,17407591 GO:0008366|axon ensheathment, ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,14849432 0,17398723 ! neural tube formation GO:0001841 41 28 0,000 0,14849432 0,17389864 ! regulation of innate immune response GO:0045088 38 29 0,000 0,15337289 0,17952043 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,15337289 0,17942912 ! protein targeting to membrane GO:0006612 53 29 0,000 0,15337289 0,1793379 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,15337289 0,17924677 ! mismatch repair GO:0006298 34 29 0,000 0,15337289 0,17915574 ! muscle cell development GO:0055001 38 29 0,000 0,15337289 0,17906479 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,15337289 0,17897394 ! eye morphogenesis GO:0048592 51 29 0,000 0,15337289 0,17888319 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,15337289 0,17879252 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,15822379 0,18435395 ! organic anion transport GO:0015711 51 30 0,000 0,15822379 0,18426061 ! cholesterol transport GO:0030301 46 30 0,000 0,15822379 0,18416736 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,15822379 0,18407421 ! spliceosome assembly GO:0000245 49 30 0,000 0,15822379 0,18398115 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,15822379 0,18388818 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,15822379 0,18379531 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,15822379 0,18370253 ! ceramide metabolic process GO:0006672 43 30 0,000 0,15822379 0,18360984 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,15822379 0,18351725 ! adult locomotory behavior GO:0008344 47 30 0,000 0,15822379 0,18342475 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,15822379 0,18333235 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,15822379 0,18324003 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,15822379 0,18314781 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,15822379 0,18305569 ! negative regulation of secretion GO:0051048 49 31 0,000 0,16304716 0,18854122 ! mammary gland development GO:0030879 57 31 0,000 0,16304716 0,18844647 ! glial cell differentiation GO:0010001 55 31 0,000 0,16304716 0,18835182 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,16304716 0,18825727 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,16304716 0,18816281 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,16304716 0,18806845 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,16304716 0,18797418 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,16304716 0,18788 ! cell fate specification GO:0001708 37 31 0,000 0,16304716 0,18778592 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,16304716 0,18769193 ! RNA modification GO:0009451 40 31 0,000 0,16304716 0,18759804 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,16784318 0,19301966 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,16784318 0,1929232 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,16784318 0,19282683 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,16784318 0,19273056 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,16784318 0,19263439 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,16784318 0,19253831 ! peripheral nervous system development GO:0007422 53 32 0,000 0,16784318 0,19244233 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,16784318 0,19234645 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,16784318 0,19225066 ! cytokine production GO:0001816 44 32 0,000 0,16784318 0,19215496 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,16784318 0,19205936 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,16784318 0,19196386 ! vesicle localization GO:0051648 47 32 0,000 0,16784318 0,19186845 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,17261199 0,19722184 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,17261199 0,19712392 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,17261199 0,19702609 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,17261199 0,19692836 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,17261199 0,19683073 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,17261199 0,19673319 ! actomyosin structure organization GO:0031032 43 33 0,000 0,17261199 0,19663575 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,17261199 0,1965384 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,17261199 0,19644115 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,17261199 0,196344 ! lipid homeostasis GO:0055088 55 33 0,000 0,17261199 0,19624695 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,17261199 0,19614999 ! regulation of proteolysis GO:0030162 50 33 0,000 0,17261199 0,19605312 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,17261199 0,19595635 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,17261199 0,19585968 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,17261199 0,1957631 ! mRNA catabolic process GO:0006402 48 34 0,000 0,17735374 0,20104169 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,17735374 0,20094266 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,17735374 0,20084372 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,17735374 0,20074488 ! feeding behavior GO:0007631 45 34 0,000 0,17735374 0,20064614 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,17735374 0,20054749 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,17735374 0,20044894 ! neuron migration GO:0001764 46 34 0,000 0,17735374 0,20035049 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,17735374 0,20025214 ! polyol metabolic process GO:0019751 44 34 0,000 0,17735374 0,20015388 ! aerobic respiration GO:0009060 47 34 0,000 0,17735374 0,20005571 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,17735374 0,19995765 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,18206858 0,20517283 ! Notch signaling pathway GO:0007219 56 35 0,000 0,18206858 0,20507235 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,18206858 0,20497197 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,18206858 0,20487169 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,18206858 0,20477151 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,18206858 0,20467143 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,18206858 0,20457144 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,18206858 0,20447155 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,18206858 0,20437176 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,18206858 0,20427207 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,18675668 0,20942972 ! negative regulation of binding GO:0051100 58 36 0,000 0,18675668 0,20932766 ! organic ether metabolic process GO:0018904 46 36 0,000 0,18675668 0,2092257 ! neural tube development GO:0021915 50 36 0,000 0,18675668 0,20912383 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,18675668 0,20902207 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,18675668 0,20892041 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,18675668 0,20881884 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,19141817 0,21392701 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,19141817 0,21382311 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,19141817 0,21371931 ! learning GO:0007612 67 37 0,000 0,19141817 0,21361561 ! ion transmembrane transport GO:0034220 56 37 0,000 0,19141817 0,21351202 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,19141817 0,21340852 ! regulation of protein secretion GO:0050708 51 37 0,000 0,19141817 0,21330513 ! amino acid activation GO:0043038 52 37 0,000 0,19141817 0,21320183 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,19141817 0,21309863 ! gliogenesis GO:0042063 71 38 0,000 0,1960532 0,21815305 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,1960532 0,21804756 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,1960532 0,21794217 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,1960532 0,21783689 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,1960532 0,2177317 ! maintenance of location in cell GO:0051651 69 38 0,000 0,1960532 0,21762662 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,20066193 0,22263504 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,20066193 0,22252769 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,20066193 0,22242045 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,20066193 0,22231331 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,20066193 0,22220628 ! JNK cascade GO:0007254 54 39 0,000 0,20066193 0,22209934 ! cell growth GO:0016049 61 39 0,000 0,20066193 0,22199251 ! synapse organization GO:0050808 55 39 0,000 0,20066193 0,22188579 ! response to calcium ion GO:0051592 58 40 0,000 0,2052445 0,226844 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,2052445 0,22673504 ! regulation of tube size GO:0035150 60 40 0,000 0,2052445 0,22662619 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,2052445 0,22651744 ! peptide metabolic process GO:0006518 56 40 0,000 0,2052445 0,2264088 ! inner ear development GO:0048839 57 40 0,000 0,2052445 0,22630027 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,2052445 0,22619183 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,2052445 0,2260835 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,2052445 0,22597528 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,2052445 0,22586716 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,20980106 0,23077114 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,20980106 0,23066083 ! endosome transport GO:0016197 71 41 0,000 0,20980106 0,23055062 ! striated muscle contraction GO:0006941 62 41 0,000 0,20980106 0,23044052 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,20980106 0,23033052 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,20980106 0,23022063 ! biopolymer methylation GO:0043414 62 41 0,000 0,20980106 0,23011085 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,20980106 0,23000117 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,21433176 0,23485615 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,21433176 0,23474431 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,21433176 0,23463258 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,21433176 0,23452096 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,21433176 0,23440944 ! excretion GO:0007588 63 42 0,000 0,21433176 0,23429803 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,21433176 0,23418672 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,21433176 0,23407552 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,21433176 0,23396443 ! neuromuscular process GO:0050905 79 43 0,000 0,21883674 0,23876874 ! tRNA processing GO:0008033 49 43 0,000 0,21883674 0,23865552 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,21883674 0,23854242 ! methylation GO:0032259 64 43 0,000 0,21883674 0,23842942 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,22331614 0,24319466 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,22331614 0,24307957 ! glycolysis GO:0006096 53 44 0,000 0,22331614 0,24296458 ! regulation of action potential GO:0001508 71 44 0,000 0,22331614 0,24284971 ! regulation of ion transport GO:0043269 57 44 0,000 0,22331614 0,24273494 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,22331614 0,24262028 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,22331614 0,24250573 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,22331614 0,24239128 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,22331614 0,24227695 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,22331614 0,24216272 ! RNA catabolic process GO:0006401 64 45 0,000 0,22777012 0,24687619 ! positive regulation of defense response GO:0031349 59 45 0,000 0,22777012 0,2467599 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,22777012 0,24664372 ! cell recognition GO:0008037 58 45 0,000 0,22777012 0,24652766 ! cell maturation GO:0048469 60 45 0,000 0,22777012 0,2464117 ! protein amino acid autophosphorylation GO:0046777 80 45 0,000 0,22777012 0,24629585 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,2321988 0,25096675 ! cell redox homeostasis GO:0045454 63 46 0,000 0,2321988 0,25084887 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,2321988 0,2507311 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,2321988 0,25061344 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,23660234 0,25524643 ! endocrine system development GO:0035270 83 47 0,000 0,23660234 0,25512676 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,23660234 0,25500721 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,23660234 0,25488777 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,23660234 0,25476844 ! chloride transport GO:0006821 67 48 0,000 0,24098088 0,25936173 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,24098088 0,25924042 ! regulation of DNA replication GO:0006275 75 48 0,000 0,24098088 0,25911922 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,24098088 0,25899814 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,24098088 0,25887717 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,24098088 0,25875631 ! regulation of endocytosis GO:0030100 63 48 0,000 0,24098088 0,25863557 ! nuclear export GO:0051168 69 48 0,000 0,24098088 0,25851493 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,24098088 0,25839441 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,24533455 0,2629401 ! sensory perception of smell GO:0007608 61 49 0,000 0,24533455 0,26281764 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,24533455 0,26269528 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,24533455 0,26257304 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,24533455 0,26245091 ! maintenance of location GO:0051235 84 49 0,000 0,24533455 0,2623289 ! proton transport GO:0015992 75 50 0,000 0,2496635 0,26683366 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,2496635 0,26670973 ! hydrogen transport GO:0006818 77 51 0,000 0,25396786 0,27118202 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,25396786 0,27105618 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,25396786 0,27093046 ! adult behavior GO:0030534 80 51 0,000 0,25396786 0,27080486 ! transition metal ion transport GO:0000041 74 52 0,000 0,25824778 0,27524091 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,25824778 0,27511342 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,25824778 0,27498606 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,25824778 0,27485881 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,26250338 0,27925892 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,26250338 0,27912981 ! single fertilization GO:0007338 59 53 0,000 0,26250338 0,27900082 ! cell projection assembly GO:0030031 76 53 0,000 0,26250338 0,27887195 ! amino acid transport GO:0006865 84 54 0,000 0,26673482 0,28323642 ! glucose catabolic process GO:0006007 66 54 0,000 0,26673482 0,28310571 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,26673482 0,28297513 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,26673482 0,28284466 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,26673482 0,28271432 ! exocytosis GO:0006887 74 55 0,000 0,27094221 0,2870415 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,27094221 0,28690934 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,27094221 0,28677731 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,27512571 0,29107136 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,27512571 0,29093753 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,27928544 0,2952006 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,27928544 0,295065 ! developmental maturation GO:0021700 75 57 0,000 0,27928544 0,29492953 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,28342153 0,29915995 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,28342153 0,29902272 ! activation of MAPK activity GO:0000187 84 59 0,000 0,28753413 0,3032226 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,28753413 0,30308363 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,28753413 0,3029448 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,29162335 0,30711251 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,29162335 0,30697195 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,29162335 0,30683152 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,29162335 0,30669123 ! regulation of heart contraction GO:0008016 91 60 0,000 0,29162335 0,30655106 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,29162335 0,30641101 ! fertilization GO:0009566 68 60 0,000 0,29162335 0,3062711 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,29568934 0,31039958 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,29568934 0,31025798 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,29568934 0,3101165 ! extracellular matrix organization GO:0030198 103 61 0,000 0,29568934 0,30997515 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,29568934 0,30983393 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,29568934 0,30969284 ! amine catabolic process GO:0009310 90 62 0,000 0,29973223 0,3137843 ! neurotransmitter transport GO:0006836 81 62 0,000 0,29973223 0,31364155 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,29973223 0,31349892 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,29973223 0,31335642 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,29973223 0,31321405 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,30375213 0,31727062 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,30375213 0,3171266 ! regulation of lipase activity GO:0060191 109 63 0,000 0,30375213 0,31698271 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,30774919 0,32100823 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,30774919 0,32086271 ! hexose catabolic process GO:0019320 82 64 0,000 0,30774919 0,32071733 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,31172353 0,32471201 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,31172353 0,32456502 ! defense response to bacterium GO:0042742 73 65 0,000 0,31172353 0,32441816 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,31172353 0,32427143 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,31172353 0,32412483 ! activation of immune response GO:0002253 83 65 0,000 0,31172353 0,32397837 ! antigen processing and presentation GO:0019882 96 66 0,000 0,31567528 0,32793729 ! regulation of immune effector process GO:0002697 101 66 0,000 0,31567528 0,32778923 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,31960457 0,33171955 ! acute inflammatory response GO:0002526 92 68 0,000 0,32351152 0,33562314 ! learning or memory GO:0007611 123 68 0,000 0,32351152 0,33547182 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,32351152 0,33532064 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,32351152 0,3351696 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,32351152 0,33501869 ! inorganic anion transport GO:0015698 93 68 0,000 0,32351152 0,33486791 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,32739626 0,33873657 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,32739626 0,33858426 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,32739626 0,33843209 ! amine transport GO:0015837 101 70 0,000 0,33125891 0,34227112 ! positive regulation of phosphorylation GO:0042327 102 70 0,000 0,33125891 0,34211742 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,33509961 0,34592868 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,33509961 0,34577348 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,33509961 0,34561843 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,33509961 0,34546351 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 0,000 0,33891846 0,34924393 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,33891846 0,34908753 ! negative regulation of transport GO:0051051 116 73 0,000 0,34271559 0,35284059 ! regulation of blood pressure GO:0008217 107 73 0,000 0,34271559 0,35268271 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,34271559 0,35252499 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,34649114 0,35624927 ! digestion GO:0007586 97 74 0,000 0,34649114 0,35609009 ! regulation of ligase activity GO:0051340 114 75 0,000 0,35024521 0,3597874 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,35024521 0,35962678 ! amine biosynthetic process GO:0009309 97 76 0,000 0,35397793 0,3632973 ! tRNA metabolic process GO:0006399 95 76 0,000 0,35397793 0,36313526 ! response to unfolded protein GO:0006986 99 76 0,000 0,35397793 0,36297336 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,35768942 0,36661572 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,35768942 0,36645241 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,35768942 0,36628926 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,35768942 0,36612624 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,35768942 0,36596338 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,3613798 0,36957472 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,3613798 0,36941046 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,3613798 0,36924635 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,36504919 0,37282999 ! cellular respiration GO:0045333 107 79 0,000 0,36504919 0,37266451 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,36504919 0,37249917 ! regulation of lyase activity GO:0051339 133 79 0,000 0,36504919 0,37233398 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,36504919 0,37216894 ! chromatin assembly GO:0031497 102 80 0,000 0,3686977 0,37572207 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,3686977 0,37555568 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,3686977 0,37538943 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,3686977 0,37522333 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,37232546 0,3787477 ! mRNA transport GO:0051028 121 81 0,000 0,37232546 0,37858026 ! regulation of neurological system process GO:0031644 122 81 0,000 0,37232546 0,37841297 ! vitamin metabolic process GO:0006766 103 81 0,000 0,37232546 0,37824583 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,37951917 0,38538371 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,37951917 0,38521363 ! regulation of defense response GO:0031347 117 84 0,000 0,38308536 0,38866181 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,38308536 0,38849044 ! sterol metabolic process GO:0016125 120 84 0,000 0,38308536 0,38831923 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,38663125 0,39174092 ! rRNA metabolic process GO:0016072 107 85 0,000 0,38663125 0,39156842 GO:0006364|rRNA processing, ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,39015697 0,39496524 ! nucleosome organization GO:0034728 114 87 0,000 0,39366262 0,39833877 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,39366262 0,3981636 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,39366262 0,39798858 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,39714832 0,40133617 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,39714832 0,40115992 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,39714832 0,40098382 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,40061418 0,40430567 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,40061418 0,40412834 ! regulation of T cell activation GO:0050863 128 89 0,000 0,40061418 0,40395117 ! hormone metabolic process GO:0042445 121 90 0,000 0,40406031 0,40724747 ! RNA localization GO:0006403 135 91 0,000 0,40748683 0,41052111 ! ATP metabolic process GO:0046034 137 91 0,000 0,40748683 0,41034138 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,41089384 0,41359117 ! positive regulation of immune response GO:0050778 121 92 0,000 0,41089384 0,41341025 ! DNA recombination GO:0006310 146 92 0,000 0,41089384 0,41322948 ! sulfur metabolic process GO:0006790 118 92 0,000 0,41089384 0,41304888 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,41428145 0,41627232 ! electron transport chain GO:0022900 123 94 0,000 0,41764978 0,41947358 ! carboxylic acid transport GO:0046942 147 95 0,000 0,42099893 0,42265279 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,42432901 0,42581009 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,42764013 0,42894562 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,42764013 0,42875863 ! calcium ion transport GO:0006816 167 99 0,000 0,4342059 0,43515189 ! extracellular structure organization GO:0043062 156 99 0,000 0,4342059 0,43496236 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,43746078 0,43803212 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,43746078 0,43784151 ! divalent metal ion transport GO:0070838 171 100 0,000 0,43746078 0,43765106 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,43746078 0,43746078