pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1218-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! neutrophil homeostasis GO:0001780 11 6 4,000 6,993E-12 1,708E-08 ! pericardium development GO:0060039 16 7 4,000 2,439E-11 2,98E-08 ! myeloid cell homeostasis GO:0002262 15 8 4,000 6,483E-11 5,279E-08 ! leukocyte homeostasis GO:0001776 50 25 5,000 7,807E-10 4,768E-07 ! embryonic hindlimb morphogenesis GO:0035116 36 16 4,000 4,923E-09 2,405E-06 ! post-embryonic development GO:0009791 76 34 5,000 5,749E-09 2,341E-06 ! embryonic forelimb morphogenesis GO:0035115 31 17 4,000 6,95E-09 2,426E-06 ! auditory receptor cell differentiation GO:0042491 36 17 4,000 6,95E-09 2,122E-06 ! forelimb morphogenesis GO:0035136 35 20 4,000 1,724E-08 4,68E-06 ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 4,000 2,909E-08 7,106E-06 ! hindlimb morphogenesis GO:0035137 47 22 4,000 2,909E-08 6,46E-06 ! inner ear receptor cell differentiation GO:0060113 42 22 4,000 2,909E-08 5,921E-06 ! mechanoreceptor differentiation GO:0042490 48 24 4,000 4,663E-08 8,763E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 1,434E-07 2,502E-05 ! ear development GO:0043583 114 66 5,000 3,481E-07 5,669E-05 ! lung development GO:0030324 165 69 5,000 4,546E-07 6,941E-05 ! homeostasis of number of cells GO:0048872 131 69 5,000 4,546E-07 6,532E-05 ! respiratory tube development GO:0030323 171 72 5,000 5,864E-07 7,959E-05 ! respiratory system development GO:0060541 175 74 5,000 6,905E-07 8,879E-05 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 2,000 7,031E-07 8,588E-05 ! response to hypoxia GO:0001666 178 81 5,000 1,181E-06 1,374E-04 ! response to oxygen levels GO:0070482 183 83 5,000 1,364E-06 1,515E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 4,000 1,397E-06 1,484E-04 ! inner ear development GO:0048839 89 53 4,000 2,857E-06 2,908E-04 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 3,000 5,467E-06 5,342E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 5,834E-06 5,482E-04 ! regulation of smooth muscle cell migration GO:0014910 27 10 2,000 8,309E-06 7,518E-04 ! embryonic limb morphogenesis GO:0030326 139 67 4,000 9,175E-06 8,005E-04 GO:0035113|embryonic appendage morphogenesis, ! appendage morphogenesis GO:0035107 150 72 4,000 1,307E-05 1,101E-03 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 151 73 4,000 1,399E-05 1,139E-03 GO:0060173|limb development, ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 2,000 1,514E-05 1,193E-03 ! negative regulation of mitotic cell cycle GO:0045930 35 13 2,000 1,962E-05 1,498E-03 ! positive regulation of protein import into nucleus GO:0042307 34 16 2,000 3,807E-05 2,818E-03 ! regulation of survival gene product expression GO:0045884 38 17 2,000 4,609E-05 3,311E-03 ! defense response to virus GO:0051607 43 18 2,000 5,513E-05 3,848E-03 ! regulation of protein localization GO:0032880 188 97 4,000 5,539E-05 3,759E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 4,000 5,817E-05 3,841E-03 ! forebrain development GO:0030900 210 98 4,000 5,817E-05 3,74E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 7,656E-05 4,796E-03 ! response to UV GO:0009411 120 55 3,000 8,345E-05 5,097E-03 ! regulation of protein catabolic process GO:0042176 126 56 3,000 8,958E-05 5,338E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 1,028E-04 5,979E-03 ! response to peptide hormone stimulus GO:0043434 129 64 3,000 1,51E-04 8,58E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 1,708E-04 9,483E-03 GO:0045844|positive regulation of striated muscle development, ! 2-oxoglutarate metabolic process GO:0006103 10 5 1,000 1,708E-04 9,273E-03 ! endochondral ossification GO:0001958 17 5 1,000 1,708E-04 9,071E-03 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! negative regulation of survival gene product expression GO:0008634 9 5 1,000 1,708E-04 8,878E-03 ! valine metabolic process GO:0006573 12 5 1,000 1,708E-04 8,693E-03 ! muscle cell migration GO:0014812 8 5 1,000 1,708E-04 8,516E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 1,708E-04 8,345E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 1,708E-04 8,182E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 1,708E-04 8,024E-03 ! B cell homeostasis GO:0001782 13 5 1,000 1,708E-04 7,873E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 1,708E-04 7,727E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 1,708E-04 7,587E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 1,708E-04 7,451E-03 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 1,714E-04 7,348E-03 ! negative regulation of cell growth GO:0030308 142 67 3,000 1,804E-04 7,6E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 1,923E-04 7,961E-03 ! mitochondrial membrane organization GO:0007006 60 27 2,000 1,923E-04 7,829E-03 ! negative regulation of cell size GO:0045792 144 69 3,000 2,022E-04 8,098E-03 ! urogenital system development GO:0001655 149 69 3,000 2,022E-04 7,967E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 3,000 2,022E-04 7,84E-03 ! early endosome to late endosome transport GO:0045022 16 6 1,000 2,555E-04 9,753E-03 ! neuron apoptosis GO:0051402 15 6 1,000 2,555E-04 9,603E-03 ! neural nucleus development GO:0048857 19 6 1,000 2,555E-04 9,457E-03 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 2,555E-04 9,316E-03 ! positive regulation of multicellular organism growth GO:0040018 55 30 2,000 2,645E-04 9,501E-03 ! regulation of catabolic process GO:0009894 173 77 3,000 3,085E-04 0,01092101 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 3,211E-04 0,01120675 ! prostate gland development GO:0030850 14 7 1,000 3,567E-04 0,01227417 ! SMAD protein complex assembly GO:0007183 13 7 1,000 3,567E-04 0,01210369 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 3,567E-04 0,01193789 ! oxaloacetate metabolic process GO:0006107 13 7 1,000 3,567E-04 0,01177657 ! regulation of granule cell precursor proliferation GO:0021936 12 7 1,000 3,567E-04 0,01161955 GO:0021940|positive regulation of granule cell precursor proliferation, ! organ growth GO:0035265 15 7 1,000 3,567E-04 0,01146666 ! fibrinolysis GO:0042730 11 7 1,000 3,567E-04 0,01131774 ! B cell lineage commitment GO:0002326 21 7 1,000 3,567E-04 0,01117264 ! T cell lineage commitment GO:0002360 16 7 1,000 3,567E-04 0,01103122 ! peptidyl-threonine modification GO:0018210 26 7 1,000 3,567E-04 0,01089332 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 3,567E-04 0,01075884 ! positive regulation of phosphorylation GO:0042327 149 81 3,000 3,744E-04 0,01115338 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 4,108E-04 0,01209255 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of growth GO:0045926 168 85 3,000 4,498E-04 0,01308115 ! cellular response to hormone stimulus GO:0032870 182 85 3,000 4,498E-04 0,01292725 ! regulation of proteolysis GO:0030162 77 36 2,000 4,566E-04 0,01297186 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 4,743E-04 0,01331928 ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 1,000 4,743E-04 0,01316793 ! male meiosis GO:0007140 9 8 1,000 4,743E-04 0,01301997 ! succinate metabolic process GO:0006105 17 8 1,000 4,743E-04 0,01287531 ! pigment granule organization GO:0048753 17 8 1,000 4,743E-04 0,01273382 ! regulation of pigmentation during development GO:0048070 25 8 1,000 4,743E-04 0,01259541 ! melanin metabolic process GO:0006582 17 8 1,000 4,743E-04 0,01245998 ! response to UV-B GO:0010224 17 8 1,000 4,743E-04 0,01232742 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 4,743E-04 0,01219766 ! regulation of protein transport GO:0051223 165 87 3,000 4,913E-04 0,0125022 GO:0070201|regulation of establishment of protein localization, ! androgen receptor signaling pathway GO:0030521 81 37 2,000 4,954E-04 0,01247754 ! regulation of DNA binding GO:0051101 167 89 3,000 5,354E-04 0,01334792 ! regulation of protein stability GO:0031647 77 38 2,000 5,363E-04 0,013233 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 5,363E-04 0,01310067 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 1,000 6,082E-04 0,01471074 GO:0010469|regulation of receptor activity, ! T cell selection GO:0045058 27 9 1,000 6,082E-04 0,01456652 ! receptor clustering GO:0043113 20 9 1,000 6,082E-04 0,0144251 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 6,082E-04 0,01428639 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 6,321E-04 0,01470726 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 7,209E-04 0,0166152 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 1,000 7,581E-04 0,01730987 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 7,581E-04 0,0171496 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 7,581E-04 0,01699226 ! positive regulation of survival gene product expression GO:0045885 26 10 1,000 7,581E-04 0,01683779 ! phosphagen metabolic process GO:0006599 17 10 1,000 7,581E-04 0,0166861 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 1,000 7,581E-04 0,01653711 ! B cell proliferation GO:0042100 19 10 1,000 7,581E-04 0,01639077 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 7,581E-04 0,01624699 ! protein sumoylation GO:0016925 17 10 1,000 7,581E-04 0,01610571 ! response to nicotine GO:0035094 20 10 1,000 7,581E-04 0,01596687 ! branching morphogenesis of a tube GO:0048754 102 45 2,000 8,83E-04 0,01843754 ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 8,83E-04 0,01828129 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 9,241E-04 0,01897112 ! blood vessel remodeling GO:0001974 30 11 1,000 9,241E-04 0,01881303 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 9,241E-04 0,01865755 ! chondrocyte differentiation GO:0002062 27 11 1,000 9,241E-04 0,01850462 ! behavioral fear response GO:0001662 27 11 1,000 9,241E-04 0,01835418 GO:0002209|behavioral defense response, ! negative regulation of ossification GO:0030279 27 11 1,000 9,241E-04 0,01820616 ! alpha-beta T cell activation GO:0046631 26 11 1,000 9,241E-04 0,01806051 ! thymus development GO:0048538 29 11 1,000 9,241E-04 0,01791717 ! oocyte development GO:0048599 20 11 1,000 9,241E-04 0,01777609 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 9,417E-04 0,01797412 ! regulation of gene-specific transcription GO:0032583 102 46 2,000 9,417E-04 0,01783478 ! negative regulation of cell migration GO:0030336 122 46 2,000 9,417E-04 0,01769759 ! positive regulation of protein transport GO:0051222 80 46 2,000 9,417E-04 0,0175625 ! response to insulin stimulus GO:0032868 98 47 2,000 1,003E-03 0,01856131 ! positive regulation of cell cycle GO:0045787 96 48 2,000 1,067E-03 0,01959023 ! mitochondrial transport GO:0006839 94 48 2,000 1,067E-03 0,01944403 ! positive regulation of DNA binding GO:0043388 83 48 2,000 1,067E-03 0,0193 ! virus-host interaction GO:0019048 30 12 1,000 1,106E-03 0,01986529 ! regulation of B cell proliferation GO:0030888 22 12 1,000 1,106E-03 0,01972028 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 1,106E-03 0,01957738 ! polyamine metabolic process GO:0006595 18 12 1,000 1,106E-03 0,01943654 ! focal adhesion formation GO:0048041 37 12 1,000 1,106E-03 0,01929771 ! histone acetylation GO:0016573 27 12 1,000 1,106E-03 0,01916084 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,106E-03 0,01902591 ! T cell homeostasis GO:0043029 28 12 1,000 1,106E-03 0,01889286 ! oocyte differentiation GO:0009994 21 12 1,000 1,106E-03 0,01876166 ! localization within membrane GO:0051668 26 12 1,000 1,106E-03 0,01863227 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 1,303E-03 0,02180944 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 1,303E-03 0,02166107 ! gland morphogenesis GO:0022612 31 13 1,000 1,303E-03 0,02151471 ! spleen development GO:0048536 24 13 1,000 1,303E-03 0,02137032 ! digestive tract morphogenesis GO:0048546 31 13 1,000 1,303E-03 0,02122785 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! cytoplasmic sequestering of protein GO:0051220 25 13 1,000 1,303E-03 0,02108727 ! positive regulation of binding GO:0051099 88 52 2,000 1,346E-03 0,02163797 ! morphogenesis of a branching structure GO:0001763 116 52 2,000 1,346E-03 0,02149655 ! positive regulation of growth GO:0045927 96 53 2,000 1,423E-03 0,02256974 ! hair follicle morphogenesis GO:0031069 27 14 1,000 1,516E-03 0,02390153 ! fear response GO:0042596 34 14 1,000 1,516E-03 0,02374831 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 1,516E-03 0,02359705 GO:0060675|ureteric bud morphogenesis, ! T cell differentiation in the thymus GO:0033077 37 14 1,000 1,516E-03 0,0234477 ! response to gamma radiation GO:0010332 30 14 1,000 1,516E-03 0,02330023 ! release of cytochrome c from mitochondria GO:0001836 31 14 1,000 1,516E-03 0,0231546 ! regulation of multicellular organism growth GO:0040014 90 55 2,000 1,584E-03 0,02403076 ! negative regulation of cell motion GO:0051271 142 55 2,000 1,584E-03 0,02388243 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 1,745E-03 0,02615359 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 1,745E-03 0,02599412 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 1,745E-03 0,02583658 ! actin cytoskeleton reorganization GO:0031532 38 15 1,000 1,745E-03 0,02568094 ! lymphocyte homeostasis GO:0002260 33 15 1,000 1,745E-03 0,02552716 ! regulation of intracellular transport GO:0032386 108 57 2,000 1,756E-03 0,02552946 ! positive regulation of cell migration GO:0030335 137 58 2,000 1,846E-03 0,02668161 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 1,000 1,989E-03 0,02858091 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 1,989E-03 0,02841377 ! kidney development GO:0001822 133 60 2,000 2,035E-03 0,02889858 ! metencephalon development GO:0022037 32 17 1,000 2,248E-03 0,03174322 ! signal complex assembly GO:0007172 47 17 1,000 2,248E-03 0,03156078 ! activation of MAPKK activity GO:0000186 43 17 1,000 2,248E-03 0,03138044 ! regulation of protein binding GO:0043393 33 17 1,000 2,248E-03 0,03120214 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 2,248E-03 0,03102585 ! negative regulation of blood coagulation GO:0030195 25 17 1,000 2,248E-03 0,03085155 ! branched chain family amino acid metabolic process GO:0009081 37 17 1,000 2,248E-03 0,0306792 ! negative regulation of homeostatic process GO:0032845 36 17 1,000 2,248E-03 0,03050876 ! regulation of mitosis GO:0007088 112 63 2,000 2,34E-03 0,03157968 GO:0051783|regulation of nuclear division, ! regulation of viral genome replication GO:0045069 30 18 1,000 2,522E-03 0,03385267 ! epidermis morphogenesis GO:0048730 43 18 1,000 2,522E-03 0,03366769 ! cell-substrate junction assembly GO:0007044 56 18 1,000 2,522E-03 0,03348471 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 2,522E-03 0,03330371 ! negative regulation of protein catabolic process GO:0042177 42 18 1,000 2,522E-03 0,03312466 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 2,000 2,558E-03 0,03341834 ! positive regulation of cell motion GO:0051272 157 65 2,000 2,558E-03 0,03324058 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 2,672E-03 0,03453445 ! activation of MAPK activity GO:0000187 124 67 2,000 2,788E-03 0,03585423 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 2,811E-03 0,0359543 ! cellular pigmentation GO:0033059 37 19 1,000 2,811E-03 0,03576704 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 3,115E-03 0,03942757 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 3,115E-03 0,03922434 ! protein amino acid acetylation GO:0006473 41 20 1,000 3,115E-03 0,03902319 ! response to alkaloid GO:0043279 38 20 1,000 3,115E-03 0,03882409 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 3,115E-03 0,03862701 ! peptidyl-serine phosphorylation GO:0018105 44 20 1,000 3,115E-03 0,03843193 ! negative regulation of translation GO:0017148 32 20 1,000 3,115E-03 0,0382388 ! negative regulation of coagulation GO:0050819 30 20 1,000 3,115E-03 0,03804761 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 3,287E-03 0,03994967 ! actin filament organization GO:0007015 167 72 2,000 3,419E-03 0,04135493 ! lipid phosphorylation GO:0046834 43 21 1,000 3,433E-03 0,04131835 ! ovarian follicle development GO:0001541 39 21 1,000 3,433E-03 0,04111581 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 3,433E-03 0,04091525 ! cell structure disassembly during apoptosis GO:0006921 32 21 1,000 3,433E-03 0,04071663 ! apoptotic nuclear changes GO:0030262 34 22 1,000 3,766E-03 0,04445061 ! ureteric bud development GO:0001657 50 22 1,000 3,766E-03 0,04423691 ! cell aging GO:0007569 48 22 1,000 3,766E-03 0,04402525 ! renal system process GO:0003014 42 22 1,000 3,766E-03 0,0438156 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 3,766E-03 0,04360795 ! peptidyl-serine modification GO:0018209 50 22 1,000 3,766E-03 0,04340225 ! sarcomere organization GO:0045214 32 22 1,000 3,766E-03 0,04319848 ! positive regulation of B cell activation GO:0050871 42 22 1,000 3,766E-03 0,04299662 ! response to cytokine stimulus GO:0034097 69 22 1,000 3,766E-03 0,04279664 ! gut development GO:0048565 44 22 1,000 3,766E-03 0,0425985 ! protein stabilization GO:0050821 41 22 1,000 3,766E-03 0,0424022 ! regulation of transcription factor activity GO:0051090 137 75 2,000 3,837E-03 0,04299411 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 2,000 3,837E-03 0,04279779 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 4,114E-03 0,04568259 ! regeneration GO:0031099 42 23 1,000 4,114E-03 0,04547588 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 4,114E-03 0,04527104 GO:0010810|regulation of cell-substrate adhesion, ! response to ethanol GO:0045471 47 23 1,000 4,114E-03 0,04506803 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 4,114E-03 0,04486683 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 4,114E-03 0,04466742 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 4,476E-03 0,04838054 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 4,476E-03 0,04816741 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 4,476E-03 0,04795615 ! response to corticosteroid stimulus GO:0031960 46 24 1,000 4,476E-03 0,04774673 ! regulation of viral reproduction GO:0050792 41 24 1,000 4,476E-03 0,04753914 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 4,476E-03 0,04733334 ! oogenesis GO:0048477 44 24 1,000 4,476E-03 0,04712932 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 4,476E-03 0,04692704 ! negative regulation of catabolic process GO:0009895 52 24 1,000 4,476E-03 0,0467265 ! activation of protein kinase activity GO:0032147 170 80 2,000 4,598E-03 0,04780041 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 4,852E-03 0,05022233 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 4,852E-03 0,05001042 ! dicarboxylic acid metabolic process GO:0043648 48 25 1,000 4,852E-03 0,04980029 ! receptor metabolic process GO:0043112 53 25 1,000 4,852E-03 0,04959192 ! interaction with host GO:0051701 66 25 1,000 4,852E-03 0,04938529 ! lymphocyte proliferation GO:0046651 55 25 1,000 4,852E-03 0,04918037 ! molting cycle process GO:0022404 52 26 1,000 5,242E-03 0,05291436 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! multicellular organismal response to stress GO:0033555 61 26 1,000 5,242E-03 0,0526966 ! regulation of blood coagulation GO:0030193 46 26 1,000 5,242E-03 0,05248063 ! positive regulation of nuclear division GO:0051785 41 26 1,000 5,242E-03 0,05226643 GO:0045840|positive regulation of mitosis, ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 1,000 5,242E-03 0,05205396 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 5,242E-03 0,05184322 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 5,242E-03 0,05163417 GO:0045936|negative regulation of phosphate metabolic process, ! osteoblast differentiation GO:0001649 63 26 1,000 5,242E-03 0,05142681 ! response to metal ion GO:0010038 158 84 2,000 5,269E-03 0,05148423 ! negative regulation of transport GO:0051051 164 85 2,000 5,445E-03 0,05299502 ! response to toxin GO:0009636 49 27 1,000 5,646E-03 0,05473063 ! leukocyte proliferation GO:0070661 59 27 1,000 5,646E-03 0,0545143 GO:0032943|mononuclear cell proliferation, ! mitochondrion organization GO:0007005 159 87 2,000 5,808E-03 0,05586182 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 6,063E-03 0,05808904 ! protein amino acid acylation GO:0043543 59 28 1,000 6,063E-03 0,05786213 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 6,063E-03 0,05763698 ! tube morphogenesis GO:0035239 194 89 2,000 6,185E-03 0,05856864 ! response to inorganic substance GO:0010035 173 90 2,000 6,379E-03 0,06017264 ! regulation of cell cycle process GO:0010564 161 90 2,000 6,379E-03 0,05994121 ! response to organic cyclic substance GO:0014070 58 29 1,000 6,495E-03 0,06079211 ! somitogenesis GO:0001756 52 29 1,000 6,495E-03 0,06056008 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 6,495E-03 0,06032981 ! ossification GO:0001503 205 91 2,000 6,577E-03 0,06086178 ! gland development GO:0048732 220 91 2,000 6,577E-03 0,06063211 ! bone development GO:0060348 206 92 2,000 6,778E-03 0,06225239 ! myofibril assembly GO:0030239 50 30 1,000 6,94E-03 0,06349787 GO:0055002|striated muscle cell development, ! negative regulation of transcription regulator activity GO:0090048 57 30 1,000 6,94E-03 0,06326094 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 1,000 6,94E-03 0,06302577 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 1,000 6,94E-03 0,06279234 ! regulation of coagulation GO:0050818 52 30 1,000 6,94E-03 0,06256064 ! regulation of membrane potential GO:0042391 179 94 2,000 7,192E-03 0,06459204 ! cell junction assembly GO:0034329 85 31 1,000 7,398E-03 0,06620509 ! ovulation cycle process GO:0022602 55 31 1,000 7,398E-03 0,06596347 ! male gonad development GO:0008584 56 31 1,000 7,398E-03 0,0657236 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 7,398E-03 0,06548547 ! response to heat GO:0009408 54 31 1,000 7,398E-03 0,06524906 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 7,404E-03 0,06506253 ! sex differentiation GO:0007548 171 96 2,000 7,62E-03 0,06671941 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 1,000 7,87E-03 0,06866652 ! metanephros development GO:0001656 81 32 1,000 7,87E-03 0,06842215 ! muscle cell development GO:0055001 52 32 1,000 7,87E-03 0,06817952 ! ovulation cycle GO:0042698 57 32 1,000 7,87E-03 0,0679386 ! hindbrain development GO:0030902 65 32 1,000 7,87E-03 0,06769938 ! response to ionizing radiation GO:0010212 74 33 1,000 8,355E-03 0,07161947 ! negative regulation of protein transport GO:0051224 74 33 1,000 8,355E-03 0,07136905 ! response to hydrogen peroxide GO:0042542 56 34 1,000 8,853E-03 0,07536055 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 1,000 8,853E-03 0,07509888 ! negative regulation of secretion GO:0051048 68 35 1,000 9,364E-03 0,07915962 ! regulation of striated muscle tissue development GO:0016202 81 35 1,000 9,364E-03 0,07888665 ! calcium-mediated signaling GO:0019722 67 35 1,000 9,364E-03 0,07861557 ! biogenic amine biosynthetic process GO:0042401 65 35 1,000 9,364E-03 0,07834633 ! regulation of muscle development GO:0048634 82 36 1,000 9,888E-03 0,08244785 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 9,888E-03 0,08216742 ! negative regulation of DNA binding GO:0043392 67 36 1,000 9,888E-03 0,08188888 ! positive regulation of cell development GO:0010720 85 36 1,000 9,888E-03 0,08161223 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 0,01042508 0,08575243 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,01042508 0,08546467 ! actomyosin structure organization GO:0031032 68 37 1,000 0,01042508 0,08517884 ! cell junction organization GO:0034330 96 37 1,000 0,01042508 0,08489491 ! tissue remodeling GO:0048771 78 37 1,000 0,01042508 0,08461286 ! maintenance of protein location in cell GO:0032507 89 37 1,000 0,01042508 0,08433269 ! female gonad development GO:0008585 71 37 1,000 0,01042508 0,08405436 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 1,000 0,01097446 0,08819278 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 0,01097446 0,08790363 ! pigment metabolic process GO:0042440 87 38 1,000 0,01097446 0,08761636 ! negative regulation of binding GO:0051100 71 39 1,000 0,01153637 0,09180243 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 0,01153637 0,09150437 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,01211069 0,09574892 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 1,000 0,01211069 0,09544005 ! cellular amide metabolic process GO:0043603 73 41 1,000 0,01269732 0,0997413 ! mesenchymal cell development GO:0014031 94 41 1,000 0,01269732 0,09942162 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! multicellular organismal metabolic process GO:0044236 64 41 1,000 0,01269732 0,09910398 ! maintenance of protein location GO:0045185 95 41 1,000 0,01269732 0,09878836 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,01329614 0,10311893 ! T cell differentiation GO:0030217 93 42 1,000 0,01329614 0,1027926 ! regulation of protein secretion GO:0050708 77 42 1,000 0,01329614 0,10246833 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,01390704 0,1068393 GO:0090047|positive regulation of transcription regulator activity, ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,01390704 0,10650438 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,01390704 0,10617155 ! segmentation GO:0035282 78 43 1,000 0,01390704 0,1058408 ! response to reactive oxygen species GO:0000302 75 44 1,000 0,01452991 0,11023783 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 1,000 0,01452991 0,10989654 ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 0,01516465 0,11434337 ! B cell differentiation GO:0030183 124 45 1,000 0,01516465 0,11399154 ! female gamete generation GO:0007292 71 45 1,000 0,01516465 0,11364187 ! developmental growth GO:0048589 88 45 1,000 0,01516465 0,11329435 ! maintenance of location in cell GO:0051651 101 45 1,000 0,01516465 0,11294894 ! pigmentation GO:0043473 103 46 1,000 0,01581115 0,1174062 ! cell growth GO:0016049 90 46 1,000 0,01581115 0,11705043 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,01713898 0,12649707 ! cellular component disassembly GO:0022411 89 48 1,000 0,01713898 0,12611605 ! endosome transport GO:0016197 127 48 1,000 0,01713898 0,12573733 ! male sex differentiation GO:0046661 93 48 1,000 0,01713898 0,12536087 ! JAK-STAT cascade GO:0007259 82 48 1,000 0,01713898 0,12498666 ! response to calcium ion GO:0051592 94 49 1,000 0,0178201 0,12956699 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 0,0178201 0,12918252 ! activation of caspase activity GO:0006919 95 50 1,000 0,01851255 0,13380523 ! regulation of ossification GO:0030278 123 50 1,000 0,01851255 0,13341053 ! regulation of gene expression, epigenetic GO:0040029 116 50 1,000 0,01851255 0,13301814 ! response to temperature stimulus GO:0009266 84 51 1,000 0,01921623 0,13766936 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,01993103 0,14237281 ! histone modification GO:0016570 104 52 1,000 0,01993103 0,14195773 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02064776 0,14663512 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02064776 0,1462101 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02064776 0,14578752 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02064776 0,14536739 ! neuron fate determination GO:0048664 7 5 0,000 0,02064776 0,14494966 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02064776 0,14453433 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02064776 0,14412138 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02064776 0,14371078 ! polyol transport GO:0015791 12 5 0,000 0,02064776 0,14330251 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02064776 0,14289655 ! response to superoxide GO:0000303 10 5 0,000 0,02064776 0,14249289 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02064776 0,1420915 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02064776 0,14169237 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02064776 0,14129547 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02064776 0,14090079 ! female meiosis GO:0007143 10 5 0,000 0,02064776 0,14050831 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02064776 0,14011801 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02064776 0,13972987 ! hypothalamus development GO:0021854 9 5 0,000 0,02064776 0,13934388 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02064776 0,13896001 ! cobalt ion transport GO:0006824 11 5 0,000 0,02064776 0,13857825 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02064776 0,13819858 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02064776 0,13782099 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02064776 0,13744546 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02064776 0,13707196 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02064776 0,1367005 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02064776 0,13633103 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02064776 0,13596357 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02064776 0,13559807 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02064776 0,13523454 ! transposition GO:0032196 9 5 0,000 0,02064776 0,13487295 ! negative chemotaxis GO:0050919 16 5 0,000 0,02064776 0,13451329 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02064776 0,13415554 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02064776 0,13379969 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02064776 0,13344572 ! behavioral response to pain GO:0048266 10 5 0,000 0,02064776 0,13309362 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02064776 0,13274338 ! Notch receptor processing GO:0007220 11 5 0,000 0,02064776 0,13239497 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02064776 0,13204838 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02064776 0,13170361 ! micturition GO:0060073 9 5 0,000 0,02064776 0,13136063 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02064776 0,13101944 ! copulation GO:0007620 9 5 0,000 0,02064776 0,13068001 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02064776 0,13034233 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02064776 0,1300064 ! bioluminescence GO:0008218 9 5 0,000 0,02064776 0,12967219 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02064776 0,1293397 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02064776 0,12900891 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02064776 0,1286798 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02064776 0,12835237 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02064776 0,12802661 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02064776 0,12770249 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02064776 0,12738001 ! grooming behavior GO:0007625 6 5 0,000 0,02064776 0,12705915 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02064776 0,12673991 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02064776 0,12642226 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02064776 0,12610621 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02064776 0,12579173 ! response to protozoan GO:0001562 13 5 0,000 0,02064776 0,12547881 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,02064776 0,12516745 ! lymph vessel development GO:0001945 10 5 0,000 0,02064776 0,12485763 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02064776 0,12454934 ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02064776 0,12424257 ! single strand break repair GO:0000012 8 5 0,000 0,02064776 0,1239373 ! parathyroid gland development GO:0060017 14 5 0,000 0,02064776 0,12363354 ! anagen GO:0042640 7 5 0,000 0,02064776 0,12333125 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02064776 0,12303045 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02064776 0,1227311 ! cytokine secretion GO:0050663 15 5 0,000 0,02064776 0,12243321 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02064776 0,12213676 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02064776 0,12184175 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02064776 0,12154815 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02064776 0,12125597 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02064776 0,12096519 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02064776 0,1206758 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02064776 0,12038779 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02064776 0,12010115 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02064776 0,11981587 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02064776 0,11953195 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,02064776 0,11924937 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02064776 0,11896812 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02064776 0,11868819 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02064776 0,11840958 ! microvillus organization GO:0032528 8 5 0,000 0,02064776 0,11813228 GO:0030033|microvillus assembly, ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02064776 0,11785627 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02064776 0,11758155 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02064776 0,1173081 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02064776 0,11703592 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02064776 0,11676501 ! polyol catabolic process GO:0046174 9 5 0,000 0,02064776 0,11649534 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02064776 0,11622692 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02064776 0,11595973 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02064776 0,11569377 ! mitochondrial fission GO:0000266 8 5 0,000 0,02064776 0,11542902 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02064776 0,11516549 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02064776 0,11490315 ! mRNA transcription GO:0009299 10 5 0,000 0,02064776 0,11464201 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02064776 0,11438205 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02064776 0,11412326 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02064776 0,11386565 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02064776 0,1136092 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02064776 0,11335389 ! monocyte activation GO:0042117 10 5 0,000 0,02064776 0,11309974 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02064776 0,11284672 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02064776 0,11259483 ! response to food GO:0032094 6 5 0,000 0,02064776 0,11234406 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02064776 0,11209441 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02064776 0,11184586 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,02064776 0,11159841 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02064776 0,11135206 ! forebrain neuron development GO:0021884 13 5 0,000 0,02064776 0,11110679 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02064776 0,1108626 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,02064776 0,11061948 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02064776 0,11037742 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02064776 0,11013643 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02064776 0,10989648 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02064776 0,10965757 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02064776 0,1094197 ! lipid glycosylation GO:0030259 7 5 0,000 0,02064776 0,10918286 ! nucleobase transport GO:0015851 6 5 0,000 0,02064776 0,10894705 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02064776 0,10871225 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02064776 0,10847846 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,02064776 0,10824567 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02064776 0,10801388 ! basic amino acid transport GO:0015802 12 5 0,000 0,02064776 0,10778308 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02064776 0,10755327 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02064776 0,10732443 ! actin nucleation GO:0045010 11 5 0,000 0,02064776 0,10709657 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02064776 0,10686967 ! depurination GO:0045007 5 5 0,000 0,02064776 0,10664373 ! depyrimidination GO:0045008 10 5 0,000 0,02064776 0,10641874 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02064776 0,1061947 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02064776 0,1059716 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02064776 0,10574944 GO:0031572|G2/M transition DNA damage checkpoint, ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02064776 0,10552821 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,02064776 0,1053079 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02064776 0,10508851 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02064776 0,10487003 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02064776 0,10465245 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02064776 0,10443578 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02064776 0,10422001 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02064776 0,10400512 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02064776 0,10379112 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02064776 0,10357799 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02064776 0,10336574 ! response to arsenic GO:0046685 11 5 0,000 0,02064776 0,10315436 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,02064776 0,10294384 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02064776 0,10273418 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02064776 0,10252537 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02064776 0,10231741 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02064776 0,10211029 ! response to mercury ion GO:0046689 8 5 0,000 0,02064776 0,10190401 ! response to cadmium ion GO:0046686 7 5 0,000 0,02064776 0,10169855 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02064776 0,10149393 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02064776 0,10129013 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02064776 0,10108714 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02064776 0,10088497 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02064776 0,1006836 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02064776 0,10048303 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02064776 0,10028327 ! decidualization GO:0046697 11 5 0,000 0,02064776 0,10008429 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02064776 0,0998861 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02064776 0,0996887 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02064776 0,09949208 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02064776 0,09929623 ! embryonic cleavage GO:0040016 6 5 0,000 0,02064776 0,09910115 ! peroxisome fission GO:0016559 5 5 0,000 0,02064776 0,09890683 ! histone demethylation GO:0016577 13 5 0,000 0,02064776 0,09871327 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02064776 0,09852047 ! mitotic recombination GO:0006312 9 5 0,000 0,02064776 0,09832843 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02064776 0,09813713 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02064776 0,09794657 ! metaphase plate congression GO:0051310 7 5 0,000 0,02064776 0,09775675 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02064776 0,09756767 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02064776 0,09737931 ! enteric nervous system development GO:0048484 8 5 0,000 0,02064776 0,09719168 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02064776 0,09700477 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02064776 0,09681859 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02064776 0,09663311 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02064776 0,09644834 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02064776 0,09626428 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02064776 0,09608092 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02064776 0,09589826 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02064776 0,09571629 ! metaphase GO:0051323 11 5 0,000 0,02064776 0,09553501 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02064776 0,09535441 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02064776 0,0951745 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02064776 0,09499526 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02064776 0,0948167 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02064776 0,0946388 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02064776 0,09446158 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02064776 0,09428501 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02064776 0,09410911 ! response to redox state GO:0051775 6 5 0,000 0,02064776 0,09393386 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02064776 0,09375926 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02064776 0,09358531 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02064776 0,09341201 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02064776 0,09323934 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02064776 0,09306731 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02064776 0,09289592 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02064776 0,09272515 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02064776 0,09255501 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02064776 0,0923855 ! striatum development GO:0021756 14 5 0,000 0,02064776 0,0922166 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02064776 0,09204833 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02064776 0,09188066 ! glial cell migration GO:0008347 10 5 0,000 0,02064776 0,09171361 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02064776 0,09154716 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02064776 0,09138131 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02064776 0,09121606 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02064776 0,09105141 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02064776 0,09088736 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02064776 0,09072389 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02064776 0,09056101 ! neuroprotection GO:0043526 8 5 0,000 0,02064776 0,09039871 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02064776 0,090237 ! regulation of sensory perception GO:0051931 8 5 0,000 0,02064776 0,09007586 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02064776 0,0899153 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02064776 0,08975531 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02064776 0,08959588 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02064776 0,08943703 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02064776 0,08927873 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02064776 0,08912099 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02064776 0,08896381 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02064776 0,08880719 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02064776 0,08865111 ! spindle assembly GO:0051225 6 5 0,000 0,02064776 0,08849558 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02064776 0,0883406 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02064776 0,08818616 ! protein palmitoylation GO:0018345 12 5 0,000 0,02064776 0,08803226 ! drug metabolic process GO:0017144 7 5 0,000 0,02064776 0,08787889 ! stem cell division GO:0017145 11 5 0,000 0,02064776 0,08772606 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,02064776 0,08757375 ! organ regeneration GO:0031100 7 5 0,000 0,02064776 0,08742198 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02064776 0,08727073 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02064776 0,08712 ! chromatin remodeling GO:0006338 122 53 1,000 0,02065684 0,08700805 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,02065684 0,0868583 ! vesicle organization GO:0016050 127 53 1,000 0,02065684 0,08670905 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 0,02065684 0,08656032 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,02065684 0,08641211 ! cartilage development GO:0051216 99 53 1,000 0,02065684 0,08626439 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,02139357 0,08918857 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 1,000 0,02139357 0,08903663 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,02139357 0,08888521 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,02214112 0,09183489 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,02366823 0,09800254 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,02366823 0,09783671 GO:0010952|positive regulation of peptidase activity, ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,02366823 0,09767145 ! aging GO:0007568 112 58 1,000 0,02444761 0,10071755 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,02444761 0,10054799 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,02444761 0,10037901 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 1,000 0,02444761 0,10021058 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,02444761 0,10004273 ! maintenance of location GO:0051235 124 58 1,000 0,02444761 0,09987543 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02472621 0,10084498 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02472621 0,1006769 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02472621 0,10050939 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02472621 0,10034243 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02472621 0,10017602 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02472621 0,10001017 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02472621 0,09984486 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02472621 0,0996801 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02472621 0,09951589 ! response to oxygen radical GO:0000305 11 6 0,000 0,02472621 0,09935221 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02472621 0,09918907 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02472621 0,09902646 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02472621 0,09886439 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02472621 0,09870285 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02472621 0,09854183 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02472621 0,09838134 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02472621 0,09822137 ! forebrain regionalization GO:0021871 9 6 0,000 0,02472621 0,09806192 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02472621 0,09790299 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02472621 0,09774457 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02472621 0,09758666 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02472621 0,09742926 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02472621 0,09727237 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02472621 0,09711599 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02472621 0,0969601 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02472621 0,09680472 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02472621 0,09664983 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02472621 0,09649544 ! malate metabolic process GO:0006108 13 6 0,000 0,02472621 0,09634154 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02472621 0,09618813 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02472621 0,0960352 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02472621 0,09588277 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02472621 0,09573081 ! protein refolding GO:0042026 15 6 0,000 0,02472621 0,09557934 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02472621 0,09542835 ! opsonization GO:0008228 8 6 0,000 0,02472621 0,09527783 ! mating behavior GO:0007617 7 6 0,000 0,02472621 0,09512778 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02472621 0,09497821 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02472621 0,09482911 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02472621 0,09468047 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02472621 0,0945323 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02472621 0,0943846 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02472621 0,09423735 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02472621 0,09409057 ! toxin metabolic process GO:0009404 11 6 0,000 0,02472621 0,09394423 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02472621 0,09379836 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02472621 0,09365293 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02472621 0,09350796 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02472621 0,09336344 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,02472621 0,09321936 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02472621 0,09307572 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02472621 0,09293253 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02472621 0,09278977 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02472621 0,09264746 ! thymic T cell selection GO:0045061 16 6 0,000 0,02472621 0,09250558 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02472621 0,09236413 ! protein lipoylation GO:0009249 10 6 0,000 0,02472621 0,09222312 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02472621 0,09208253 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02472621 0,09194238 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02472621 0,09180265 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02472621 0,09166334 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02472621 0,09152446 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02472621 0,091386 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02472621 0,09124795 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02472621 0,09111032 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02472621 0,09097311 ! hyperosmotic response GO:0006972 10 6 0,000 0,02472621 0,0908363 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02472621 0,09069991 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02472621 0,09056393 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02472621 0,09042836 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02472621 0,09029319 ! urea metabolic process GO:0019627 7 6 0,000 0,02472621 0,09015842 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02472621 0,09002406 ! neutrophil activation GO:0042119 7 6 0,000 0,02472621 0,08989009 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02472621 0,08975653 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02472621 0,08962336 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02472621 0,08949058 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02472621 0,0893582 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02472621 0,08922621 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02472621 0,08909461 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02472621 0,08896339 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02472621 0,08883256 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02472621 0,08870212 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02472621 0,08857206 ! carnitine transport GO:0015879 10 6 0,000 0,02472621 0,08844238 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02472621 0,08831307 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02472621 0,08818415 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02472621 0,0880556 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02472621 0,08792743 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02472621 0,08779963 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02472621 0,0876722 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02472621 0,08754513 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02472621 0,08741844 ! establishment of spindle localization GO:0051293 16 6 0,000 0,02472621 0,08729211 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02472621 0,08716615 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02472621 0,08704055 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,02472621 0,08691531 ! astrocyte development GO:0014002 16 6 0,000 0,02472621 0,08679044 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02472621 0,08666592 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02472621 0,08654175 ! interaction with symbiont GO:0051702 14 6 0,000 0,02472621 0,08641794 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02472621 0,08629449 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02472621 0,08617139 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02472621 0,08604864 ! response to copper ion GO:0046688 10 6 0,000 0,02472621 0,08592623 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02472621 0,08580418 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02472621 0,08568247 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02472621 0,08556111 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02472621 0,08544009 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02472621 0,08531941 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02472621 0,08519907 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02472621 0,08507907 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02472621 0,08495941 ! hair follicle maturation GO:0048820 8 6 0,000 0,02472621 0,08484009 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02472621 0,0847211 ! Schwann cell development GO:0014044 15 6 0,000 0,02472621 0,08460244 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02472621 0,08448412 ! response to pheromone GO:0019236 6 6 0,000 0,02472621 0,08436612 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02472621 0,08424846 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02472621 0,08413112 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02472621 0,08401411 ! subpallium development GO:0021544 15 6 0,000 0,02472621 0,08389742 ! neural tube patterning GO:0021532 8 6 0,000 0,02472621 0,08378106 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02472621 0,08366502 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02472621 0,0835493 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02472621 0,0834339 ! G2 phase GO:0051319 16 6 0,000 0,02472621 0,08331882 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02472621 0,08320405 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02472621 0,0830896 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02472621 0,08297547 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02472621 0,08286165 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02472621 0,08274814 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02472621 0,08263494 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02472621 0,08252205 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02472621 0,08240947 ! receptor internalization GO:0031623 11 6 0,000 0,02472621 0,0822972 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,02472621 0,08218523 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,02472621 0,08207356 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02472621 0,0819622 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02472621 0,08185114 ! protein deubiquitination GO:0016579 16 6 0,000 0,02472621 0,08174038 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,02472621 0,08162992 ! protein destabilization GO:0031648 9 6 0,000 0,02472621 0,08151976 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02472621 0,0814099 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02472621 0,08130033 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02472621 0,08119105 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02472621 0,08108207 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02472621 0,08097338 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02472621 0,08086498 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02472621 0,08075688 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02472621 0,08064906 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02472621 0,08054152 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02472621 0,08043428 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02472621 0,08032732 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02472621 0,08022064 ! neural plate development GO:0001840 9 6 0,000 0,02472621 0,08011425 ! catecholamine transport GO:0051937 9 6 0,000 0,02472621 0,08000814 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02472621 0,07990231 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02472621 0,07979675 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02472621 0,07969148 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02472621 0,07958649 ! maternal placenta development GO:0001893 12 6 0,000 0,02472621 0,07948177 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02472621 0,07937732 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02472621 0,07927315 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02472621 0,07916926 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02472621 0,07906563 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02472621 0,07896228 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02472621 0,07885919 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02472621 0,07875638 GO:0055081|anion homeostasis, ! lipid modification GO:0030258 112 60 1,000 0,02603749 0,08282498 ! DNA catabolic process GO:0006308 94 60 1,000 0,02603749 0,08271728 ! viral reproductive process GO:0022415 132 62 1,000 0,02766822 0,08778373 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,02766822 0,08766987 ! skeletal system morphogenesis GO:0048705 118 63 1,000 0,02849867 0,09018425 ! tRNA transcription GO:0009304 17 7 0,000 0,0287878 0,09098136 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,0287878 0,09086381 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,0287878 0,09074657 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,0287878 0,09062962 ! regulation of helicase activity GO:0051095 16 7 0,000 0,0287878 0,09051298 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,0287878 0,09039664 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,0287878 0,0902806 ! sleep GO:0030431 16 7 0,000 0,0287878 0,09016486 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,0287878 0,09004941 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,0287878 0,08993426 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,0287878 0,0898194 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,0287878 0,08970483 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0287878 0,08959056 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,0287878 0,08947658 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,0287878 0,08936288 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0287878 0,08924948 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,0287878 0,08913636 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,0287878 0,08902353 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,0287878 0,08891098 ! glycolipid transport GO:0046836 11 7 0,000 0,0287878 0,08879872 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,0287878 0,08868675 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,0287878 0,08857505 ! neuron adhesion GO:0007158 14 7 0,000 0,0287878 0,08846363 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,0287878 0,0883525 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,0287878 0,08824164 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,0287878 0,08813106 ! mRNA stabilization GO:0048255 18 7 0,000 0,0287878 0,08802076 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,0287878 0,08791074 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,0287878 0,08780098 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,0287878 0,08769151 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,0287878 0,0875823 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,0287878 0,08747337 ! lipoprotein transport GO:0042953 14 7 0,000 0,0287878 0,08736471 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,0287878 0,08725631 ! rhythmic behavior GO:0007622 17 7 0,000 0,0287878 0,08714819 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,0287878 0,08704033 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,0287878 0,08693274 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,0287878 0,08682542 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,0287878 0,08671836 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,0287878 0,08661156 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,0287878 0,08650503 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,0287878 0,08639876 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,0287878 0,08629275 ! mechanosensory behavior GO:0007638 16 7 0,000 0,0287878 0,086187 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,0287878 0,0860815 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,0287878 0,08597627 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,0287878 0,08587129 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,0287878 0,08576657 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0287878 0,08566211 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0287878 0,08555789 ! spinal cord patterning GO:0021511 14 7 0,000 0,0287878 0,08545394 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,0287878 0,08535023 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,0287878 0,08524677 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,0287878 0,08514357 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,0287878 0,08504062 ! adrenal gland development GO:0030325 17 7 0,000 0,0287878 0,08493791 ! cysteine metabolic process GO:0006534 13 7 0,000 0,0287878 0,08483545 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,0287878 0,08473324 ! ovulation GO:0030728 10 7 0,000 0,0287878 0,08463127 ! adenohypophysis development GO:0021984 11 7 0,000 0,0287878 0,08452955 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,0287878 0,08442808 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,0287878 0,08432685 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,0287878 0,08422586 ! microtubule nucleation GO:0007020 21 7 0,000 0,0287878 0,08412511 ! proline biosynthetic process GO:0006561 10 7 0,000 0,0287878 0,0840246 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,0287878 0,08392433 ! thyroid hormone generation GO:0006590 13 7 0,000 0,0287878 0,0838243 ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,0287878 0,08372451 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0287878 0,08362496 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,0287878 0,08352564 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,0287878 0,08342656 ! galactose metabolic process GO:0006012 13 7 0,000 0,0287878 0,08332771 ! vesicle fusion GO:0006906 20 7 0,000 0,0287878 0,0832291 ! response to dietary excess GO:0002021 8 7 0,000 0,0287878 0,08313072 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,0287878 0,08303257 ! intracellular pH reduction GO:0051452 13 7 0,000 0,0287878 0,08293466 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,0287878 0,08283697 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,0287878 0,08273952 ! nucleoside transport GO:0015858 11 7 0,000 0,0287878 0,08264229 ! nucleoside salvage GO:0043174 11 7 0,000 0,0287878 0,08254529 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,0287878 0,08244852 ! male sex determination GO:0030238 15 7 0,000 0,0287878 0,08235198 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,0287878 0,08225566 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,0287878 0,08215957 ! parturition GO:0007567 16 7 0,000 0,0287878 0,0820637 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,0287878 0,08196805 ! rRNA modification GO:0000154 14 7 0,000 0,0287878 0,08187263 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,0287878 0,08177743 ! spindle checkpoint GO:0031577 16 7 0,000 0,0287878 0,08168245 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,0287878 0,08158769 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,0287878 0,08149315 ! monocyte differentiation GO:0030224 16 7 0,000 0,0287878 0,08139883 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,0287878 0,08130473 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,0287878 0,08121084 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,0287878 0,08111717 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,0287878 0,08102372 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,0287878 0,08093048 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,0287878 0,08083746 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,0287878 0,08074465 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,0287878 0,08065205 ! eating behavior GO:0042755 8 7 0,000 0,0287878 0,08055967 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,0287878 0,08046749 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,0287878 0,08037553 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,0287878 0,08028378 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,0287878 0,08019223 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,0287878 0,0801009 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,0287878 0,08000977 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,0287878 0,07991885 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,0287878 0,07982814 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,0287878 0,07973763 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,0287878 0,07964733 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,0287878 0,07955723 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,0287878 0,07946733 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,0287878 0,07937764 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,0287878 0,07928815 ! histone ubiquitination GO:0016574 9 7 0,000 0,0287878 0,07919886 ! regulation of meiosis GO:0040020 12 7 0,000 0,0287878 0,07910977 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,0287878 0,07902089 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,0287878 0,0789322 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,0287878 0,07884371 ! membrane to membrane docking GO:0022614 14 7 0,000 0,0287878 0,07875542 ! transcription termination GO:0006353 14 7 0,000 0,0287878 0,07866733 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,0287878 0,07857943 ! anaphase GO:0051322 18 7 0,000 0,0287878 0,07849173 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,0287878 0,07840422 ! axonal fasciculation GO:0007413 19 7 0,000 0,0287878 0,07831691 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,0287878 0,0782298 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,0287878 0,07814288 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,0287878 0,07805615 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,0287878 0,07796961 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,0287878 0,07788327 ! thiamin metabolic process GO:0006772 7 7 0,000 0,0287878 0,07779711 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0287878 0,07771115 ! antibiotic transport GO:0042891 9 7 0,000 0,0287878 0,07762537 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,0287878 0,07753979 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,0287878 0,07745439 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,0287878 0,07736918 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,0287878 0,07728416 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,0287878 0,07719933 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,0287878 0,07711468 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,0287878 0,07703022 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,0287878 0,07694594 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,0287878 0,07686185 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,0287878 0,07677794 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,0287878 0,07669421 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,0287878 0,07661066 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,0287878 0,0765273 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,0287878 0,07644412 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,0287878 0,07636112 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,0287878 0,0762783 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,0287878 0,07619565 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,0287878 0,07611319 ! muscle adaptation GO:0043500 13 7 0,000 0,0287878 0,07603091 ! embryonic heart tube development GO:0035050 14 7 0,000 0,0287878 0,0759488 ! retina homeostasis GO:0001895 12 7 0,000 0,0287878 0,07586687 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,0287878 0,07578512 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,0287878 0,07570354 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,0287878 0,07562214 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,0287878 0,07554091 ! protein amino acid autophosphorylation GO:0046777 157 64 1,000 0,02933903 0,07690478 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,03018922 0,07904852 GO:0048609|reproductive process in a multicellular organism, ! gonad development GO:0008406 115 66 1,000 0,03104914 0,08121312 ! secondary metabolic process GO:0019748 125 67 1,000 0,0319187 0,08339828 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,0327978 0,08560367 ! viral reproduction GO:0016032 142 68 1,000 0,0327978 0,08551231 ! regulation of lipase activity GO:0060191 137 68 1,000 0,0327978 0,08542114 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 1,000 0,0327978 0,08533017 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,03283258 0,08532978 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,03283258 0,0852391 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,03283258 0,08514861 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,03283258 0,08505831 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,03283258 0,08496821 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,03283258 0,0848783 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,03283258 0,08478857 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,03283258 0,08469904 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,03283258 0,08460969 ! meiotic prophase I GO:0007128 14 8 0,000 0,03283258 0,08452054 ! response to zinc ion GO:0010043 12 8 0,000 0,03283258 0,08443157 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,03283258 0,08434279 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,03283258 0,08425419 ! oligopeptide transport GO:0006857 16 8 0,000 0,03283258 0,08416578 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,03283258 0,08407756 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,03283258 0,08398952 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,03283258 0,08390166 ! signal peptide processing GO:0006465 12 8 0,000 0,03283258 0,08381399 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,03283258 0,0837265 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,03283258 0,0836392 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,03283258 0,08355207 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,03283258 0,08346513 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,03283258 0,08337837 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,03283258 0,08329179 ! estrogen metabolic process GO:0008210 17 8 0,000 0,03283258 0,08320538 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,03283258 0,08311916 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,03283258 0,08303312 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,03283258 0,08294725 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,03283258 0,08286156 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03283258 0,08277605 ! reflex GO:0060004 17 8 0,000 0,03283258 0,08269071 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,03283258 0,08260555 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,03283258 0,08252057 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,03283258 0,08243576 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,03283258 0,08235112 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,03283258 0,08226666 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,03283258 0,08218237 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,03283258 0,08209825 ! astrocyte differentiation GO:0048708 19 8 0,000 0,03283258 0,08201431 ! histidine catabolic process GO:0006548 10 8 0,000 0,03283258 0,08193053 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,03283258 0,08184693 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,03283258 0,0817635 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,03283258 0,08168023 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,03283258 0,08159714 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,03283258 0,08151422 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,03283258 0,08143146 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,03283258 0,08134887 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,03283258 0,08126645 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,03283258 0,0811842 ! macrophage activation GO:0042116 13 8 0,000 0,03283258 0,08110211 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,03283258 0,08102019 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,03283258 0,08093844 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,03283258 0,08085685 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,03283258 0,08077542 ! purine salvage GO:0043101 12 8 0,000 0,03283258 0,08069416 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,03283258 0,08061306 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03283258 0,08053212 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,03283258 0,08045134 ! osteoblast development GO:0002076 17 8 0,000 0,03283258 0,08037073 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,03283258 0,08029028 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,03283258 0,08020999 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,03283258 0,08012986 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,03283258 0,08004989 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,03283258 0,07997008 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,03283258 0,07989043 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,03283258 0,07981094 ! intermediate filament organization GO:0045109 12 8 0,000 0,03283258 0,0797316 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,03283258 0,07965242 ! cellular extravasation GO:0045123 13 8 0,000 0,03283258 0,0795734 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,03283258 0,07949454 ! response to antibiotic GO:0046677 11 8 0,000 0,03283258 0,07941583 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,03283258 0,07933728 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,03283258 0,07925888 ! DNA topological change GO:0006265 12 8 0,000 0,03283258 0,07918064 ! response to tropane GO:0014073 15 8 0,000 0,03283258 0,07910255 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,03283258 0,07902462 ! melanosome transport GO:0032402 13 8 0,000 0,03283258 0,07894684 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,03283258 0,07886921 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,03283258 0,07879174 ! mast cell activation GO:0045576 14 8 0,000 0,03283258 0,07871442 ! multicellular organismal aging GO:0010259 20 8 0,000 0,03283258 0,07863725 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,03283258 0,07856023 ! gas homeostasis GO:0033483 14 8 0,000 0,03283258 0,07848336 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,03283258 0,07840664 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,03283258 0,07833007 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,03283258 0,07825365 ! nucleosome disassembly GO:0006337 14 8 0,000 0,03283258 0,07817738 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,03283258 0,07810126 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,03283258 0,07802528 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,03283258 0,07794946 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,03283258 0,07787378 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,03283258 0,07779824 ! intracellular lipid transport GO:0032365 16 8 0,000 0,03283258 0,07772286 ! response to tumor cell GO:0002347 16 8 0,000 0,03283258 0,07764762 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,03283258 0,07757252 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,03283258 0,07749758 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,03283258 0,07742277 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,03283258 0,07734811 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,03283258 0,07727359 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,03283258 0,07719922 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,03283258 0,07712499 ! hormone catabolic process GO:0042447 17 8 0,000 0,03283258 0,0770509 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,03283258 0,07697696 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,03283258 0,07690315 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,03283258 0,07682949 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,03283258 0,07675597 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,03283258 0,07668259 GO:0010828|positive regulation of glucose transport, ! adult feeding behavior GO:0008343 10 8 0,000 0,03283258 0,07660935 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,03283258 0,07653625 ! ATP catabolic process GO:0006200 11 8 0,000 0,03283258 0,07646329 ! blastocyst growth GO:0001832 19 8 0,000 0,03283258 0,07639047 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,03283258 0,07631778 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,03283258 0,07624524 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,03283258 0,07617283 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,03283258 0,07610056 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,03283258 0,07602843 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,03283258 0,07595643 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,03283258 0,07588457 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,03283258 0,07581285 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,03283258 0,07574126 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,03283258 0,0756698 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,03283258 0,07559848 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,03283258 0,0755273 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,03283258 0,07545625 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,03283258 0,07538533 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,03283258 0,07531455 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,03283258 0,07524389 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,03283258 0,07517337 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,03283258 0,07510299 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,03283258 0,07503273 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,03283258 0,07496261 ! negative regulation of protein kinase activity GO:0006469 144 69 1,000 0,03368635 0,07684011 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 1,000 0,03368635 0,07676843 ! negative regulation of kinase activity GO:0033673 145 70 1,000 0,03458426 0,07874123 ! germ cell development GO:0007281 133 70 1,000 0,03458426 0,07866792 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,03549143 0,08065633 ! B cell activation GO:0042113 179 72 1,000 0,03640777 0,08266188 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 1,000 0,03640777 0,08258513 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 1,000 0,03640777 0,08250852 ! axon extension GO:0048675 16 9 0,000 0,03686063 0,08345738 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,03686063 0,08338011 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03686063 0,08330298 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03686063 0,08322599 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03686063 0,08314914 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03686063 0,08307243 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03686063 0,08299587 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03686063 0,08291944 ! reproductive behavior GO:0019098 22 9 0,000 0,03686063 0,08284316 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03686063 0,08276702 ! Golgi to endosome transport GO:0006895 25 9 0,000 0,03686063 0,08269102 ! UTP metabolic process GO:0046051 10 9 0,000 0,03686063 0,08261515 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,03686063 0,08253943 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,03686063 0,08246384 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03686063 0,0823884 ! artery development GO:0060840 25 9 0,000 0,03686063 0,08231309 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03686063 0,08223791 ! regulation of glycolysis GO:0006110 20 9 0,000 0,03686063 0,08216288 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03686063 0,08208798 ! equilibrioception GO:0050957 20 9 0,000 0,03686063 0,08201322 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,03686063 0,0819386 ! chemosensory behavior GO:0007635 21 9 0,000 0,03686063 0,08186411 ! microtubule bundle formation GO:0001578 22 9 0,000 0,03686063 0,08178975 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,03686063 0,08171553 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,03686063 0,08164145 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03686063 0,0815675 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03686063 0,08149368 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03686063 0,08142 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03686063 0,08134645 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03686063 0,08127303 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03686063 0,08119974 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03686063 0,08112659 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03686063 0,08105357 ! protein targeting to ER GO:0045047 25 9 0,000 0,03686063 0,08098068 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03686063 0,08090792 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,03686063 0,08083529 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03686063 0,08076279 ! glycine catabolic process GO:0006546 15 9 0,000 0,03686063 0,08069043 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03686063 0,08061819 ! endosome organization GO:0007032 20 9 0,000 0,03686063 0,08054608 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03686063 0,0804741 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03686063 0,08040225 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03686063 0,08033052 ! mannose metabolic process GO:0006013 13 9 0,000 0,03686063 0,08025893 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03686063 0,08018746 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03686063 0,08011612 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,03686063 0,0800449 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03686063 0,07997382 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03686063 0,07990285 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03686063 0,07983202 ! retinol metabolic process GO:0042572 20 9 0,000 0,03686063 0,07976131 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03686063 0,07969072 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03686063 0,07962026 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,03686063 0,07954993 ! macrophage differentiation GO:0030225 15 9 0,000 0,03686063 0,07947971 ! oligodendrocyte development GO:0014003 11 9 0,000 0,03686063 0,07940963 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,03686063 0,07933966 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03686063 0,07926982 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03686063 0,0792001 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03686063 0,07913051 ! response to amine stimulus GO:0014075 13 9 0,000 0,03686063 0,07906103 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03686063 0,07899168 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03686063 0,07892245 ! erythrocyte development GO:0048821 17 9 0,000 0,03686063 0,07885334 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03686063 0,07878435 ! renal water homeostasis GO:0003091 15 9 0,000 0,03686063 0,07871549 ! postreplication repair GO:0006301 25 9 0,000 0,03686063 0,07864674 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03686063 0,07857811 ! icosanoid secretion GO:0032309 15 9 0,000 0,03686063 0,0785096 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03686063 0,07844122 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03686063 0,07837295 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03686063 0,0783048 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03686063 0,07823676 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03686063 0,07816885 ! sterol catabolic process GO:0016127 14 9 0,000 0,03686063 0,07810105 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,03686063 0,07803338 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03686063 0,07796581 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03686063 0,07789837 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,03686063 0,07783104 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,03686063 0,07776383 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03686063 0,07769674 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,03686063 0,07762976 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03686063 0,07756289 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03686063 0,07749614 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03686063 0,07742951 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03686063 0,07736299 ! purine base metabolic process GO:0006144 25 9 0,000 0,03686063 0,07729658 ! pigment granule transport GO:0051904 17 9 0,000 0,03686063 0,07723029 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,03686063 0,07716411 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03686063 0,07709804 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03686063 0,07703209 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03686063 0,07696625 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03686063 0,07690053 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03686063 0,07683491 ! mitochondrion localization GO:0051646 18 9 0,000 0,03686063 0,07676941 ! humoral immune response GO:0006959 115 73 1,000 0,03733319 0,07768739 ! regulation of caspase activity GO:0043281 136 74 1,000 0,03826761 0,07956406 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,03826761 0,0794964 ! negative regulation of transferase activity GO:0051348 155 74 1,000 0,03826761 0,07942886 ! rhythmic process GO:0048511 142 75 1,000 0,03921093 0,08131774 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,04016305 0,08322166 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,04016305 0,08315114 ! regulation of developmental growth GO:0048638 16 10 0,000 0,04087202 0,08454728 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,04087202 0,08447575 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,04087202 0,08440434 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,04087202 0,08433305 ! associative learning GO:0008306 21 10 0,000 0,04087202 0,08426189 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,04087202 0,08419084 ! phosphate transport GO:0006817 24 10 0,000 0,04087202 0,08411991 ! cell volume homeostasis GO:0006884 17 10 0,000 0,04087202 0,0840491 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,04087202 0,08397841 ! CTP metabolic process GO:0046036 11 10 0,000 0,04087202 0,08390784 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,04087202 0,08383739 ! GTP metabolic process GO:0046039 11 10 0,000 0,04087202 0,08376706 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,04087202 0,08369684 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,04087202 0,08362675 ! social behavior GO:0035176 29 10 0,000 0,04087202 0,08355676 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,04087202 0,0834869 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,04087202 0,08341715 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,04087202 0,08334752 ! androgen metabolic process GO:0008209 17 10 0,000 0,04087202 0,08327801 ! phospholipid efflux GO:0033700 19 10 0,000 0,04087202 0,08320861 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,04087202 0,08313933 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,04087202 0,08307016 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,04087202 0,08300111 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,04087202 0,08293217 ! lung alveolus development GO:0048286 26 10 0,000 0,04087202 0,08286335 ! pathogenesis GO:0009405 17 10 0,000 0,04087202 0,08279464 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04087202 0,08272604 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,04087202 0,08265756 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,04087202 0,08258919 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,04087202 0,08252094 ! endoderm development GO:0007492 18 10 0,000 0,04087202 0,08245279 ! arginine catabolic process GO:0006527 17 10 0,000 0,04087202 0,08238476 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,04087202 0,08231685 ! proline metabolic process GO:0006560 13 10 0,000 0,04087202 0,08224904 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,04087202 0,08218134 GO:0005978|glycogen biosynthetic process, ! V(D)J recombination GO:0033151 34 10 0,000 0,04087202 0,08211376 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,04087202 0,08204629 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,04087202 0,08197893 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,04087202 0,08191168 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,04087202 0,08184454 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,04087202 0,08177751 ! multicellular organism growth GO:0035264 19 10 0,000 0,04087202 0,08171058 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,04087202 0,08164377 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,04087202 0,08157707 ! ruffle organization GO:0031529 17 10 0,000 0,04087202 0,08151048 ! epithelial cell development GO:0002064 21 10 0,000 0,04087202 0,08144399 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,04087202 0,08137762 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,04087202 0,08131135 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,04087202 0,08124519 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,04087202 0,08117913 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,04087202 0,08111319 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,04087202 0,08104735 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,04087202 0,08098162 ! motor axon guidance GO:0008045 22 10 0,000 0,04087202 0,08091599 ! copper ion homeostasis GO:0055070 13 10 0,000 0,04087202 0,08085047 ! regulation of bone resorption GO:0045124 25 10 0,000 0,04087202 0,08078506 ! protein heterooligomerization GO:0051291 17 10 0,000 0,04087202 0,08071975 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,04087202 0,08065455 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,04087202 0,08058945 ! segment specification GO:0007379 15 10 0,000 0,04087202 0,08052446 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,04087202 0,08045958 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,04087202 0,08039479 ! blastoderm segmentation GO:0007350 19 10 0,000 0,04087202 0,08033012 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,04087202 0,08026554 ! response to dsRNA GO:0043331 23 10 0,000 0,04087202 0,08020107 ! DNA ligation GO:0006266 18 10 0,000 0,04087202 0,0801367 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,04087202 0,08007244 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,04087202 0,08000828 ! melanosome localization GO:0032400 16 10 0,000 0,04087202 0,07994422 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,04087202 0,07988027 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,04087202 0,07981641 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,04087202 0,07975266 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,04087202 0,07968901 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,04087202 0,07962547 ! induction of an organ GO:0001759 17 10 0,000 0,04087202 0,07956202 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,04087202 0,07949867 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,04087202 0,07943543 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,04087202 0,07937228 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,04087202 0,07930924 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04087202 0,0792463 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,04087202 0,07918345 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,04087202 0,07912071 ! salivary gland development GO:0007431 28 10 0,000 0,04087202 0,07905806 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,04087202 0,07899552 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,04087202 0,07893307 ! midbrain development GO:0030901 14 10 0,000 0,04087202 0,07887072 ! musculoskeletal movement GO:0050881 16 10 0,000 0,04087202 0,07880847 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,04087202 0,07874632 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,04087202 0,07868427 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,04087202 0,07862231 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,04087202 0,07856045 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,04087202 0,07849869 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,04087202 0,07843703 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,04087202 0,07837546 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,04087202 0,07831399 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,04087202 0,07825261 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,04087202 0,07819133 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,04087202 0,07813015 ! blastocyst formation GO:0001825 18 10 0,000 0,04087202 0,07806906 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,04087202 0,07800807 ! cerebellar cortex development GO:0021695 16 10 0,000 0,04087202 0,07794718 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,04087202 0,07788638 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,04087202 0,07782567 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,04087202 0,07776506 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,04087202 0,07770454 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,04112391 0,07812263 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,04112391 0,07806193 ! positive regulation of ligase activity GO:0051351 130 77 1,000 0,04112391 0,07800132 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,04209339 0,07977825 ! blood coagulation GO:0007596 151 79 1,000 0,04307143 0,08156861 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,04307143 0,08150542 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,04307143 0,08144234 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 1,000 0,04405793 0,08324324 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,04405793 0,08317891 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,04486681 0,08464063 ! respiratory burst GO:0045730 17 11 0,000 0,04486681 0,08457532 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,04486681 0,08451011 ! neuron fate specification GO:0048665 18 11 0,000 0,04486681 0,084445 ! telencephalon cell migration GO:0022029 23 11 0,000 0,04486681 0,08437999 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,04486681 0,08431509 ! thyroid gland development GO:0030878 26 11 0,000 0,04486681 0,08425028 ! synapsis GO:0007129 14 11 0,000 0,04486681 0,08418557 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,04486681 0,08412096 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,04486681 0,08405645 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,04486681 0,08399204 ! response to pain GO:0048265 27 11 0,000 0,04486681 0,08392773 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,04486681 0,08386351 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,04486681 0,0837994 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,04486681 0,08373538 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,04486681 0,08367146 ! bone resorption GO:0045453 16 11 0,000 0,04486681 0,08360764 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,04486681 0,08354391 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,04486681 0,08348028 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,04486681 0,08341675 ! melanocyte differentiation GO:0030318 20 11 0,000 0,04486681 0,08335332 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,04486681 0,08328998 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,04486681 0,08322674 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,04486681 0,08316359 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,04486681 0,08310054 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,04486681 0,08303758 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,04486681 0,08297472 ! UV protection GO:0009650 20 11 0,000 0,04486681 0,08291196 ! adult heart development GO:0007512 16 11 0,000 0,04486681 0,08284929 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,04486681 0,08278672 ! macroautophagy GO:0016236 19 11 0,000 0,04486681 0,08272423 ! temperature homeostasis GO:0001659 18 11 0,000 0,04486681 0,08266185 ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,04486681 0,08259956 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,04486681 0,08253736 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,04486681 0,08247525 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,04486681 0,08241324 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,04486681 0,08235132 ! regulation of organ growth GO:0046620 14 11 0,000 0,04486681 0,0822895 ! pigment granule localization GO:0051875 20 11 0,000 0,04486681 0,08222777 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,04486681 0,08216613 ! vasoconstriction GO:0042310 20 11 0,000 0,04486681 0,08210458 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,04486681 0,08204312 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,04486681 0,08198176 ! embryonic axis specification GO:0000578 19 11 0,000 0,04486681 0,08192049 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,04486681 0,08185931 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,04486681 0,08179822 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,04486681 0,08173722 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,04486681 0,08167631 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,04486681 0,0816155 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,04486681 0,08155477 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,04486681 0,08149413 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,04486681 0,08143359 ! prophase GO:0051324 17 11 0,000 0,04486681 0,08137313 ! neuroblast proliferation GO:0007405 25 11 0,000 0,04486681 0,08131277 ! nucleosome positioning GO:0016584 15 11 0,000 0,04486681 0,08125249 ! regulation of isotype switching GO:0045191 24 11 0,000 0,04486681 0,0811923 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,04486681 0,08113221 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,04486681 0,0810722 ! apical protein localization GO:0045176 18 11 0,000 0,04486681 0,08101228 ! acid secretion GO:0046717 20 11 0,000 0,04486681 0,08095245 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,04486681 0,0808927 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,04486681 0,08083305 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,04486681 0,08077348 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,04486681 0,080714 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,04486681 0,08065461 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,04486681 0,0805953 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,04486681 0,08053608 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,04486681 0,08047695 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,04486681 0,08041791 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,04486681 0,08035895 ! embryonic gut development GO:0048566 19 11 0,000 0,04486681 0,08030008 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,04486681 0,0802413 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,04486681 0,0801826 ! activation of innate immune response GO:0002218 16 11 0,000 0,04486681 0,08012398 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,04486681 0,08006546 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,04486681 0,08000702 ! lysogeny GO:0030069 22 11 0,000 0,04486681 0,07994866 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,04486681 0,07989039 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,04486681 0,0798322 ! sequestering of metal ion GO:0051238 15 11 0,000 0,04486681 0,0797741 ! regulation of embryonic development GO:0045995 35 11 0,000 0,04486681 0,07971608 ! nucleus localization GO:0051647 22 11 0,000 0,04486681 0,07965815 ! meiosis GO:0007126 143 81 1,000 0,0450528 0,07993027 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 1,000 0,0450528 0,07987227 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,04605596 0,08159152 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,04605596 0,08153239 ! meiotic cell cycle GO:0051321 144 82 1,000 0,04605596 0,08147335 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,04706732 0,08320222 ! response to drug GO:0042493 149 83 1,000 0,04706732 0,08314205 ! T cell activation GO:0042110 189 84 1,000 0,0480868 0,08488154 ! response to nutrient GO:0007584 135 84 1,000 0,0480868 0,08482026 ! regulation of ligase activity GO:0051340 147 84 1,000 0,0480868 0,08475906 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,04884507 0,08603354 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,04884507 0,08597155 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,04884507 0,08590966 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,04884507 0,08584785 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,04884507 0,08578614 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,04884507 0,08572451 ! protein complex disassembly GO:0043241 28 12 0,000 0,04884507 0,08566297 GO:0043624|cellular protein complex disassembly, ! regulation of cell projection assembly GO:0060491 33 12 0,000 0,04884507 0,08560152 ! hippocampus development GO:0021766 29 12 0,000 0,04884507 0,08554015 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,04884507 0,08547888 ! T cell proliferation GO:0042098 32 12 0,000 0,04884507 0,08541769 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,04884507 0,08535659 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,04884507 0,08529558 ! ventral spinal cord development GO:0021517 25 12 0,000 0,04884507 0,08523465 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,04884507 0,08517381 ! drug transport GO:0015893 16 12 0,000 0,04884507 0,08511306 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,04884507 0,0850524 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,04884507 0,08499182 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,04884507 0,08493133 ! mitotic spindle organization GO:0007052 23 12 0,000 0,04884507 0,08487092 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,04884507 0,0848106 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,04884507 0,08475037 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,04884507 0,08469022 ! lipid digestion GO:0044241 21 12 0,000 0,04884507 0,08463015 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,04884507 0,08457017 ! entry into host cell GO:0030260 34 12 0,000 0,04884507 0,08451028 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04884507 0,08445047 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,04884507 0,08439075 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,04884507 0,08433111 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,04884507 0,08427155 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,04884507 0,08421208 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,04884507 0,08415269 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,04884507 0,08409339 ! snRNA metabolic process GO:0016073 30 12 0,000 0,04884507 0,08403416 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,04884507 0,08397503 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,04884507 0,08391597 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,04884507 0,083857 ! cranial nerve development GO:0021545 23 12 0,000 0,04884507 0,08379811 ! fucose catabolic process GO:0019317 25 12 0,000 0,04884507 0,08373931 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,04884507 0,08368058 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,04884507 0,08362194 ! autonomic nervous system development GO:0048483 24 12 0,000 0,04884507 0,08356339 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,04884507 0,08350491 ! zymogen activation GO:0031638 18 12 0,000 0,04884507 0,08344651 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,04884507 0,0833882 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,04884507 0,08332997 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,04884507 0,08327182 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,04884507 0,08321375 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,04884507 0,08315576 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,04884507 0,08309785 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,04884507 0,08304002 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,04884507 0,08298228 ! defense response to fungus GO:0050832 15 12 0,000 0,04884507 0,08292461 ! developmental induction GO:0031128 22 12 0,000 0,04884507 0,08286702 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,04884507 0,08280952 ! lamellipodium assembly GO:0030032 24 12 0,000 0,04884507 0,08275209 ! response to cold GO:0009409 17 12 0,000 0,04884507 0,08269474 ! establishment of cell polarity GO:0030010 21 12 0,000 0,04884507 0,08263748 ! regulation of synapse organization GO:0050807 18 12 0,000 0,04884507 0,08258029 ! hemostasis GO:0007599 165 85 1,000 0,04911432 0,08297806 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,04911432 0,08292072 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,04911432 0,08286345 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,05014979 0,08455206 ! regulation of lyase activity GO:0051339 169 86 1,000 0,05014979 0,08449374 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,05014979 0,08443551 GO:0002696|positive regulation of leukocyte activation, ! amine biosynthetic process GO:0009309 146 88 1,000 0,05224425 0,0879013 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,05280688 0,08878679 ! cGMP metabolic process GO:0046068 18 13 0,000 0,05280688 0,08872573 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,05280688 0,08866475 ! regulation of chemokine production GO:0032642 18 13 0,000 0,05280688 0,08860385 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,05280688 0,08854304 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,05280688 0,08848231 ! peroxisomal transport GO:0043574 28 13 0,000 0,05280688 0,08842166 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,05280688 0,0883611 ! cartilage condensation GO:0001502 22 13 0,000 0,05280688 0,08830062 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,05280688 0,08824022 ! organelle fusion GO:0048284 36 13 0,000 0,05280688 0,08817991 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,05280688 0,08811968 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,05280688 0,08805953 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,05280688 0,08799946 ! endocrine pancreas development GO:0031018 25 13 0,000 0,05280688 0,08793947 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,05280688 0,08787957 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,05280688 0,08781975 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,05280688 0,08776001 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,05280688 0,08770035 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,05280688 0,08764077 ! methionine metabolic process GO:0006555 31 13 0,000 0,05280688 0,08758127 ! plasma membrane organization GO:0007009 27 13 0,000 0,05280688 0,08752185 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,05280688 0,08746251 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,05280688 0,08740326 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,05280688 0,08734408 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,05280688 0,08728499 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,05280688 0,08722597 ! cytokine metabolic process GO:0042107 24 13 0,000 0,05280688 0,08716703 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,05280688 0,08710818 ! exocrine system development GO:0035272 34 13 0,000 0,05280688 0,0870494 ! asymmetric protein localization GO:0008105 24 13 0,000 0,05280688 0,0869907 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,05280688 0,08693208 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,05280688 0,08687354 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,05280688 0,08681508 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,05280688 0,0867567 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,05280688 0,08669839 ! protein homotetramerization GO:0051289 24 13 0,000 0,05280688 0,08664017 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,05280688 0,08658202 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,05280688 0,08652395 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,05280688 0,08646596 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,05280688 0,08640804 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,05280688 0,08635021 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,05280688 0,08629245 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,05280688 0,08623477 ! histone methylation GO:0016571 29 13 0,000 0,05280688 0,08617716 ! chromatin silencing GO:0006342 29 13 0,000 0,05280688 0,08611963 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,05280688 0,08606218 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,05280688 0,08600481 ! regulation of epidermis development GO:0045682 19 13 0,000 0,05280688 0,08594751 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,05280688 0,08589029 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,05280688 0,08583314 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,05280688 0,08577607 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,05280688 0,08571908 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,05280688 0,08566216 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,05280688 0,08560531 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,05280688 0,08554855 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,05280688 0,08549185 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,05280688 0,08543524 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,05280688 0,0853787 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,05280688 0,08532223 ! insulin secretion GO:0030073 24 13 0,000 0,05280688 0,08526584 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,05280688 0,08520952 ! acrosome reaction GO:0007340 19 13 0,000 0,05280688 0,08515327 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,05280688 0,0850971 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,05280688 0,08504101 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,05330307 0,08578353 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,05436952 0,08744222 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,05544351 0,08911085 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell adhesion GO:0030155 241 92 1,000 0,05652496 0,09078927 ! rRNA transcription GO:0009303 28 14 0,000 0,0567523 0,09109452 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,0567523 0,09103471 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,0567523 0,09097497 ! water transport GO:0006833 21 14 0,000 0,0567523 0,09091532 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,0567523 0,09085574 ! non-recombinational repair GO:0000726 29 14 0,000 0,0567523 0,09079624 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,0567523 0,09073682 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,0567523 0,09067748 ! RNA polyadenylation GO:0043631 32 14 0,000 0,0567523 0,09061821 ! lipid localization GO:0010876 32 14 0,000 0,0567523 0,09055902 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,0567523 0,09049991 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,0567523 0,09044087 ! regulated secretory pathway GO:0045055 24 14 0,000 0,0567523 0,09038192 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,0567523 0,09032304 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,0567523 0,09026423 ! arginine metabolic process GO:0006525 21 14 0,000 0,0567523 0,0902055 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,0567523 0,09014685 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,0567523 0,09008828 ! regulation of heart rate GO:0002027 25 14 0,000 0,0567523 0,09002978 ! organic alcohol transport GO:0015850 29 14 0,000 0,0567523 0,08997136 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,0567523 0,08991301 ! embryo implantation GO:0007566 30 14 0,000 0,0567523 0,08985474 ! neutral amino acid transport GO:0015804 28 14 0,000 0,0567523 0,08979654 ! bone mineralization GO:0030282 18 14 0,000 0,0567523 0,08973842 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,0567523 0,08968038 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,0567523 0,0896224 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,0567523 0,08956451 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,0567523 0,08950669 ! regulation of cellular pH GO:0030641 27 14 0,000 0,0567523 0,08944894 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,0567523 0,08939127 ! ribosome assembly GO:0042255 18 14 0,000 0,0567523 0,08933367 ! cerebellum development GO:0021549 23 14 0,000 0,0567523 0,08927615 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,0567523 0,0892187 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,0567523 0,08916132 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,0567523 0,08910402 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,0567523 0,0890468 ! NADP metabolic process GO:0006739 24 14 0,000 0,0567523 0,08898964 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,0567523 0,08893256 ! oxygen transport GO:0015671 22 14 0,000 0,0567523 0,08887555 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,0567523 0,08881862 ! male genitalia development GO:0030539 26 14 0,000 0,0567523 0,08876175 ! regulation of RNA stability GO:0043487 33 14 0,000 0,0567523 0,08870497 ! regulation of axon extension GO:0030516 43 14 0,000 0,0567523 0,08864825 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,0567523 0,0885916 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,0567523 0,08853503 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 1,000 0,0576138 0,08982163 GO:0010498|proteasomal protein catabolic process, ! female pregnancy GO:0007565 166 94 1,000 0,05870993 0,09147217 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,05981329 0,09313184 ! lactation GO:0007595 30 15 0,000 0,06068139 0,09442333 ! reproductive cellular process GO:0048610 22 15 0,000 0,06068139 0,09436323 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,06068139 0,0943032 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,06068139 0,09424325 ! superoxide anion generation GO:0042554 22 15 0,000 0,06068139 0,09418338 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,06068139 0,09412358 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,06068139 0,09406385 ! copper ion transport GO:0006825 22 15 0,000 0,06068139 0,09400421 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,06068139 0,09394463 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,06068139 0,09388514 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,06068139 0,09382572 ! sulfate transport GO:0008272 27 15 0,000 0,06068139 0,09376637 ! response to cAMP GO:0051591 25 15 0,000 0,06068139 0,0937071 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,06068139 0,0936479 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,06068139 0,09358878 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,06068139 0,09352974 ! response to hexose stimulus GO:0009746 25 15 0,000 0,06068139 0,09347077 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,06068139 0,09341187 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,06068139 0,09335304 ! vesicle coating GO:0006901 38 15 0,000 0,06068139 0,09329429 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,06068139 0,09323562 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,06068139 0,09317702 ! regulation of exocytosis GO:0017157 26 15 0,000 0,06068139 0,09311849 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,06068139 0,09306003 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,06068139 0,09300165 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,06068139 0,09294334 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,06068139 0,09288511 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,06068139 0,09282695 ! regulation of vasodilation GO:0042312 27 15 0,000 0,06068139 0,09276886 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,06068139 0,09271084 ! histone deacetylation GO:0016575 24 15 0,000 0,06068139 0,0926529 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,06068139 0,09259502 ! water homeostasis GO:0030104 28 15 0,000 0,06068139 0,09253722 ! cofactor transport GO:0051181 30 15 0,000 0,06068139 0,0924795 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,06068139 0,09242184 ! muscle maintenance GO:0046716 26 15 0,000 0,06068139 0,09236426 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,06068139 0,09230675 ! intestinal absorption GO:0050892 31 15 0,000 0,06068139 0,09224931 ! dopamine metabolic process GO:0042417 35 15 0,000 0,06068139 0,09219194 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,06068139 0,09213464 ! heme biosynthetic process GO:0006783 33 15 0,000 0,06068139 0,09207741 ! cell killing GO:0001906 32 15 0,000 0,06068139 0,09202026 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,06068139 0,09196317 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,06068139 0,09190616 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,06068139 0,09184922 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,06068139 0,09179234 ! actin filament polymerization GO:0030041 27 15 0,000 0,06068139 0,09173554 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,06068139 0,09167881 ! response to protein stimulus GO:0051789 158 96 1,000 0,06092379 0,09198815 ! biogenic amine metabolic process GO:0006576 162 97 1,000 0,06204136 0,0936177 ! leukocyte differentiation GO:0002521 232 98 1,000 0,06316593 0,09525578 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,06316593 0,09519701 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,06459423 0,09728958 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,06459423 0,09722963 ! positive regulation of cell size GO:0045793 29 16 0,000 0,06459423 0,09716976 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,06459423 0,09710996 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,06459423 0,09705024 ! bone remodeling GO:0046849 28 16 0,000 0,06459423 0,09699059 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,06459423 0,09693101 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,06459423 0,09687151 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,06459423 0,09681208 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,06459423 0,09675272 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,06459423 0,09669344 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,06459423 0,09663423 ! startle response GO:0001964 28 16 0,000 0,06459423 0,09657509 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,06459423 0,09651602 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,06459423 0,09645702 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,06459423 0,0963981 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,06459423 0,09633925 ! protein polyubiquitination GO:0000209 41 16 0,000 0,06459423 0,09628047 ! glutamate metabolic process GO:0006536 25 16 0,000 0,06459423 0,09622176 ! pituitary gland development GO:0021983 30 16 0,000 0,06459423 0,09616313 ! response to osmotic stress GO:0006970 27 16 0,000 0,06459423 0,09610456 ! lysosomal transport GO:0007041 31 16 0,000 0,06459423 0,09604607 ! fructose metabolic process GO:0006000 25 16 0,000 0,06459423 0,09598765 ! L-amino acid transport GO:0015807 33 16 0,000 0,06459423 0,0959293 ! stem cell development GO:0048864 46 16 0,000 0,06459423 0,09587102 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,06459423 0,09581281 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,06459423 0,09575467 ! intermediate filament-based process GO:0045103 36 16 0,000 0,06459423 0,0956966 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,06459423 0,0956386 ! negative regulation of immune response GO:0050777 38 16 0,000 0,06459423 0,09558067 ! axon cargo transport GO:0008088 46 16 0,000 0,06459423 0,09552282 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,06459423 0,09546503 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,06459423 0,09540731 ! DNA replication initiation GO:0006270 28 16 0,000 0,06459423 0,09534966 ! neuron recognition GO:0008038 40 16 0,000 0,06459423 0,09529208 ! mRNA splice site selection GO:0006376 44 16 0,000 0,06459423 0,09523458 ! tissue regeneration GO:0042246 27 16 0,000 0,06459423 0,09517714 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,06459423 0,09511977 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,06459423 0,09506247 ! biomineral formation GO:0031214 22 16 0,000 0,06459423 0,09500523 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,06459423 0,09494807 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,06459423 0,09489098 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,06459423 0,09483395 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,06459423 0,09477699 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,06459423 0,0947201 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,06459423 0,09466328 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,06459423 0,09460653 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,06459423 0,09454985 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,06459423 0,09449323 ! peptide hormone processing GO:0016486 27 16 0,000 0,06459423 0,09443668 ! skeletal muscle tissue development GO:0007519 223 100 1,000 0,06543571 0,09560972 GO:0060538|skeletal muscle organ development, ! positive regulation of cell killing GO:0031343 36 17 0,000 0,06849087 0,10001387 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,06849087 0,09995412 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,06849087 0,09989445 ! filopodium assembly GO:0046847 42 17 0,000 0,06849087 0,09983484 ! endothelial cell migration GO:0043542 31 17 0,000 0,06849087 0,09977531 ! gene silencing by RNA GO:0031047 38 17 0,000 0,06849087 0,09971585 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,06849087 0,09965646 ! glial cell development GO:0021782 28 17 0,000 0,06849087 0,09959714 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,06849087 0,09953789 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,06849087 0,09947872 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,06849087 0,09941961 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,06849087 0,09936057 ! myoblast differentiation GO:0045445 50 17 0,000 0,06849087 0,0993016 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,06849087 0,0992427 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,06849087 0,09918388 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,06849087 0,09912512 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,06849087 0,09906643 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,06849087 0,09900781 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,06849087 0,09894926 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,06849087 0,09889078 ! membrane budding GO:0006900 42 17 0,000 0,06849087 0,09883237 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,06849087 0,09877403 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,06849087 0,09871575 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,06849087 0,09865755 ! genitalia development GO:0048806 32 17 0,000 0,06849087 0,09859941 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,06849087 0,09854134 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,06849087 0,09848334 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,06849087 0,09842541 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,06849087 0,09836755 ! steroid catabolic process GO:0006706 34 17 0,000 0,06849087 0,09830975 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,06849087 0,09825203 ! gas transport GO:0015669 26 17 0,000 0,06849087 0,09819437 ! organic cation transport GO:0015695 32 17 0,000 0,06849087 0,09813677 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,06849087 0,09807925 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,06849087 0,09802179 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,07237139 0,10351482 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,07237139 0,10345425 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,07237139 0,10339375 ! limbic system development GO:0021761 40 18 0,000 0,07237139 0,10333332 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,07237139 0,10327297 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,07237139 0,10321268 ! adult walking behavior GO:0007628 36 18 0,000 0,07237139 0,10315246 ! patterning of blood vessels GO:0001569 43 18 0,000 0,07237139 0,10309231 ! heart looping GO:0001947 34 18 0,000 0,07237139 0,10303224 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,07237139 0,10297223 ! centrosome cycle GO:0007098 26 18 0,000 0,07237139 0,10291229 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,07237139 0,10285242 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,07237139 0,10279263 ! glycine metabolic process GO:0006544 30 18 0,000 0,07237139 0,1027329 ! glutamine metabolic process GO:0006541 29 18 0,000 0,07237139 0,10267324 ! response to retinoic acid GO:0032526 31 18 0,000 0,07237139 0,10261365 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,07237139 0,10255413 ! DNA integration GO:0015074 32 18 0,000 0,07237139 0,10249468 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,07237139 0,10243529 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,07237139 0,10237598 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,07237139 0,10231673 ! neural crest cell migration GO:0001755 41 18 0,000 0,07237139 0,10225756 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,07237139 0,10219845 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,07237139 0,10213941 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,07237139 0,10208044 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,07237139 0,10202153 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,07237139 0,1019627 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,07237139 0,10190393 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,07237139 0,10184523 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,07237139 0,1017866 ! detection of bacterium GO:0016045 22 18 0,000 0,07237139 0,10172803 ! nerve development GO:0021675 34 18 0,000 0,07237139 0,10166953 ! microspike assembly GO:0030035 46 18 0,000 0,07237139 0,1016111 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,07237139 0,10155274 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,07237139 0,10149444 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,07623586 0,10685267 ! positive regulation of translation GO:0045727 31 19 0,000 0,07623586 0,1067914 ! negative regulation of defense response GO:0031348 27 19 0,000 0,07623586 0,10673021 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,07623586 0,10666908 ! neuron maturation GO:0042551 46 19 0,000 0,07623586 0,10660802 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,07623586 0,10654703 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,07623586 0,10648611 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,07623586 0,10642526 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,07623586 0,10636448 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,07623586 0,10630377 ! inositol metabolic process GO:0006020 33 19 0,000 0,07623586 0,10624313 ! memory GO:0007613 34 19 0,000 0,07623586 0,10618256 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,07623586 0,10612206 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,07623586 0,10606162 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,07623586 0,10600126 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,07623586 0,10594096 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,07623586 0,10588073 ! cerebral cortex development GO:0021987 40 19 0,000 0,07623586 0,10582057 ! pigmentation during development GO:0048066 42 19 0,000 0,07623586 0,10576048 ! response to vitamin A GO:0033189 32 19 0,000 0,07623586 0,10570046 ! heme metabolic process GO:0042168 40 19 0,000 0,07623586 0,1056405 ! neuromuscular junction development GO:0007528 43 19 0,000 0,07623586 0,10558062 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,07623586 0,1055208 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,07623586 0,10546105 ! response to fungus GO:0009620 26 19 0,000 0,07623586 0,10540136 ! peptide cross-linking GO:0018149 39 19 0,000 0,07623586 0,10534175 ! protein export from nucleus GO:0006611 40 19 0,000 0,07623586 0,1052822 ! heart process GO:0003015 32 19 0,000 0,07623586 0,10522272 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,07623586 0,1051633 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,07623586 0,10510396 ! visual learning GO:0008542 38 19 0,000 0,07623586 0,10504468 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,07623586 0,10498546 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,07623586 0,10492632 ! vitamin transport GO:0051180 31 19 0,000 0,07623586 0,10486723 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,07623586 0,10480822 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,07623586 0,10474927 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,07623586 0,10469039 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,07623586 0,10463158 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,07623586 0,10457283 ! cilium assembly GO:0042384 38 19 0,000 0,07623586 0,10451415 ! peptide hormone secretion GO:0030072 32 19 0,000 0,07623586 0,10445553 ! protein secretion GO:0009306 45 20 0,000 0,08008434 0,10966706 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,08008434 0,10960562 ! positive regulation of ossification GO:0045778 50 20 0,000 0,08008434 0,10954425 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,08008434 0,10948295 ! skin development GO:0043588 42 20 0,000 0,08008434 0,10942172 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,08008434 0,10936056 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,08008434 0,10929946 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,08008434 0,10923843 ! response to vitamin GO:0033273 36 20 0,000 0,08008434 0,10917747 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,08008434 0,10911658 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,08008434 0,10905576 GO:0010675|regulation of cellular carbohydrate metabolic process, ! bile acid metabolic process GO:0008206 34 20 0,000 0,08008434 0,10899501 ! retinoid metabolic process GO:0001523 34 20 0,000 0,08008434 0,10893432 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,08008434 0,1088737 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,08008434 0,10881315 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,08008434 0,10875266 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,08008434 0,10869224 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 0,000 0,08008434 0,10863189 ! body fluid secretion GO:0007589 33 20 0,000 0,08008434 0,10857161 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,08008434 0,10851139 ! peptide secretion GO:0002790 38 20 0,000 0,08008434 0,10845124 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,08008434 0,10839116 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,08008434 0,10833114 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,08008434 0,10827119 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,08008434 0,1082113 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,08008434 0,10815148 ! cell-cell junction organization GO:0045216 43 20 0,000 0,08008434 0,10809173 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,08008434 0,10803205 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,08008434 0,10797243 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,08008434 0,10791287 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,08008434 0,10785338 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,08008434 0,10779396 ! regulation of glucose import GO:0046324 30 20 0,000 0,08008434 0,1077346 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,08008434 0,10767531 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,08008434 0,10761608 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,08008434 0,10755692 ! regulation of cell killing GO:0031341 46 21 0,000 0,08391689 0,11264228 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,08391689 0,11258043 ! hormone secretion GO:0046879 39 21 0,000 0,08391689 0,11251864 ! cAMP metabolic process GO:0046058 41 21 0,000 0,08391689 0,11245691 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,08391689 0,11239526 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,08391689 0,11233367 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,08391689 0,11227216 ! smooth muscle contraction GO:0006939 48 21 0,000 0,08391689 0,1122107 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,08391689 0,11214932 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,08391689 0,112088 ! plasma membrane fusion GO:0045026 33 21 0,000 0,08391689 0,11202675 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,08391689 0,11196557 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,08391689 0,11190445 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,08391689 0,1118434 ! sensory perception of pain GO:0019233 33 21 0,000 0,08391689 0,11178242 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,08391689 0,1117215 ! diencephalon development GO:0021536 36 21 0,000 0,08391689 0,11166065 ! collagen fibril organization GO:0030199 62 21 0,000 0,08391689 0,11159987 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,08391689 0,11153915 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,08391689 0,1114785 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,08391689 0,11141791 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,08391689 0,11135739 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,08391689 0,11129694 ! collagen catabolic process GO:0030574 29 21 0,000 0,08391689 0,11123655 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,08391689 0,11117622 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,08391689 0,11111597 ! sperm-egg recognition GO:0035036 23 21 0,000 0,08391689 0,11105577 ! actin filament-based movement GO:0030048 47 21 0,000 0,08391689 0,11099564 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,08391689 0,11093558 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,08773358 0,1159184 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,08773358 0,11585575 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,08773358 0,11579316 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,08773358 0,11573063 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,08773358 0,11566818 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 59 22 0,000 0,08773358 0,11560579 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,08773358 0,11554347 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,08773358 0,11548121 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,08773358 0,11541903 ! cellular response to starvation GO:0009267 37 22 0,000 0,08773358 0,11535691 ! vacuolar transport GO:0007034 41 22 0,000 0,08773358 0,11529485 ! central nervous system neuron development GO:0021954 47 22 0,000 0,08773358 0,11523287 ! fucose metabolic process GO:0006004 44 22 0,000 0,08773358 0,11517095 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,08773358 0,11510909 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,08773358 0,11504731 ! stem cell differentiation GO:0048863 57 22 0,000 0,08773358 0,11498559 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,08773358 0,11492393 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,08773358 0,11486234 ! cytolysis GO:0019835 27 22 0,000 0,08773358 0,11480082 ! vasodilation GO:0042311 40 22 0,000 0,08773358 0,11473936 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,08773358 0,11467797 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,08773358 0,11461665 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 0,08773358 0,11455539 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,08773358 0,11449419 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,08773358 0,11443306 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,08773358 0,114372 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,08773358 0,114311 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,08773358 0,11425007 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,08773358 0,1141892 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,08773358 0,1141284 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,08773358 0,11406766 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,08773358 0,11400698 ! positive regulation of DNA replication GO:0045740 44 23 0,000 0,09153447 0,11888289 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,09153447 0,11881972 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,09153447 0,11875662 ! gluconeogenesis GO:0006094 38 23 0,000 0,09153447 0,11869359 ! glycerol metabolic process GO:0006071 40 23 0,000 0,09153447 0,11863062 ! viral genome replication GO:0019079 44 23 0,000 0,09153447 0,11856772 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,09153447 0,11850489 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,09153447 0,11844212 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,09153447 0,11837942 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,09153447 0,11831678 ! axis specification GO:0009798 43 23 0,000 0,09153447 0,11825421 ! visual behavior GO:0007632 46 23 0,000 0,09153447 0,11819171 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,09153447 0,11812928 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,09153447 0,11806691 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,09153447 0,1180046 ! peroxisome organization GO:0007031 43 23 0,000 0,09153447 0,11794236 ! lysosome organization GO:0007040 47 23 0,000 0,09153447 0,11788019 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,09153447 0,11781808 ! vesicle targeting GO:0006903 49 23 0,000 0,09153447 0,11775604 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,09153447 0,11769406 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,09153447 0,11763215 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,09153447 0,1175703 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,09153447 0,11750852 ! DNA modification GO:0006304 36 23 0,000 0,09153447 0,11744681 ! fatty acid transport GO:0015908 47 23 0,000 0,09153447 0,11738515 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,09153447 0,11732357 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,09153447 0,11726204 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,09153447 0,11720059 ! hormone transport GO:0009914 41 23 0,000 0,09153447 0,11713919 ! cell-cell recognition GO:0009988 28 23 0,000 0,09153447 0,11707786 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,09153447 0,1170166 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,09153447 0,1169554 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,09153447 0,11689426 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,09531964 0,12166451 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,09531964 0,12160098 ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,09531964 0,12153752 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,09531964 0,12147412 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,09531964 0,12141078 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,09531964 0,12134752 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,09531964 0,12128431 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,09531964 0,12122118 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,09531964 0,12115811 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,09531964 0,1210951 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,09531964 0,12103216 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,09531964 0,12096929 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,09531964 0,12090648 GO:0051693|actin filament capping, ! sex determination GO:0007530 48 24 0,000 0,09531964 0,12084374 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,09531964 0,12078106 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,09531964 0,12071845 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,09531964 0,1206559 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,09531964 0,12059341 ! membrane depolarization GO:0051899 45 24 0,000 0,09531964 0,12053099 ! pallium development GO:0021543 56 24 0,000 0,09531964 0,12046864 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,09531964 0,12040635 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,09531964 0,12034412 ! platelet activation GO:0030168 41 24 0,000 0,09531964 0,12028196 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,09531964 0,12021987 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,09531964 0,12015783 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,09531964 0,12009586 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,09531964 0,12003396 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,09531964 0,11997212 ! regulation of amine transport GO:0051952 41 24 0,000 0,09531964 0,11991034 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,09531964 0,11984863 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,09908914 0,12452406 ! myeloid leukocyte differentiation GO:0002573 46 25 0,000 0,09908914 0,12446004 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,09908914 0,12439608 ! leukocyte adhesion GO:0007159 55 25 0,000 0,09908914 0,12433219 ! phototransduction GO:0007602 37 25 0,000 0,09908914 0,12426836 ! keratinization GO:0031424 37 25 0,000 0,09908914 0,1242046 ! vasculogenesis GO:0001570 49 25 0,000 0,09908914 0,12414091 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,09908914 0,12407728 ! vacuole organization GO:0007033 49 25 0,000 0,09908914 0,12401372 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,09908914 0,12395022 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,09908914 0,12388678 ! chromosome condensation GO:0030261 48 25 0,000 0,09908914 0,12382341 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,09908914 0,12376011 ! regulation of behavior GO:0050795 48 25 0,000 0,09908914 0,12369687 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,09908914 0,12363369 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,09908914 0,12357058 ! immunoglobulin production GO:0002377 62 25 0,000 0,09908914 0,12350754 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,09908914 0,12344456 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,09908914 0,12338164 ! liver development GO:0001889 55 25 0,000 0,09908914 0,12331878 ! protein tetramerization GO:0051262 57 25 0,000 0,09908914 0,12325599 ! myelination GO:0042552 50 26 0,000 0,10284304 0,12786033 ! initiation of viral infection GO:0019059 60 26 0,000 0,10284304 0,1277953 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,10284304 0,12773033 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,10284304 0,12766542 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,10284304 0,12760059 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,10284304 0,12753581 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,10284304 0,12747111 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,10284304 0,12740647 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,10284304 0,12734189 ! digestive system process GO:0022600 49 26 0,000 0,10284304 0,12727738 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,10284304 0,12721294 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,10284304 0,12714856 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,10284304 0,12708425 ! neural crest cell development GO:0014032 59 26 0,000 0,10284304 0,12702 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,10284304 0,12695581 ! negative regulation of cell development GO:0010721 83 26 0,000 0,10284304 0,12689169 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,10284304 0,12682764 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,10284304 0,12676365 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,10284304 0,12669972 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,10284304 0,12663586 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,10284304 0,12657207 ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,10284304 0,12650834 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,10284304 0,12644467 ! blastocyst development GO:0001824 50 26 0,000 0,10284304 0,12638106 ! telomere organization GO:0032200 46 26 0,000 0,10284304 0,12631752 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,10284304 0,12625405 ! neural tube closure GO:0001843 58 26 0,000 0,10284304 0,12619063 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,10284304 0,12612729 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,10284304 0,126064 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,10284304 0,12600078 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,10658141 0,13051548 ! embryonic pattern specification GO:0009880 49 27 0,000 0,10658141 0,13045009 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,10658141 0,13038477 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,10658141 0,13031951 ! positive regulation of cell projection organization GO:0031346 66 27 0,000 0,10658141 0,13025432 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,10658141 0,13018919 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,10658141 0,13012413 ! iron ion transport GO:0006826 65 27 0,000 0,10658141 0,13005913 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,10658141 0,1299942 ! superoxide metabolic process GO:0006801 41 27 0,000 0,10658141 0,12992933 ! tube lumen formation GO:0035148 59 27 0,000 0,10658141 0,12986453 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,10658141 0,12979979 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,10658141 0,12973512 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,10658141 0,12967051 ! response to starvation GO:0042594 47 27 0,000 0,10658141 0,12960596 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,10658141 0,12954148 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,10658141 0,12947707 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,10658141 0,12941271 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,10658141 0,12934842 ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,10658141 0,1292842 ! neuron fate commitment GO:0048663 52 28 0,000 0,1103043 0,1337337 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,1103043 0,13366736 ! vesicle docking GO:0048278 55 28 0,000 0,1103043 0,13360109 ! circadian rhythm GO:0007623 56 28 0,000 0,1103043 0,13353489 ! dendrite development GO:0016358 67 28 0,000 0,1103043 0,13346875 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,1103043 0,13340267 ! fat cell differentiation GO:0045444 57 28 0,000 0,1103043 0,13333667 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,1103043 0,13327072 ! sperm motility GO:0030317 37 28 0,000 0,1103043 0,13320485 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,1103043 0,13313903 ! base-excision repair GO:0006284 41 28 0,000 0,1103043 0,13307329 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,1103043 0,1330076 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,1103043 0,13294198 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,1103043 0,13287643 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,1103043 0,13281094 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,1103043 0,13274552 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,1103043 0,13268016 ! glutathione metabolic process GO:0006749 42 28 0,000 0,1103043 0,13261486 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,1103043 0,13254963 ! lipid oxidation GO:0034440 48 28 0,000 0,1103043 0,13248447 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,1103043 0,13241936 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,1103043 0,13235432 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,11401178 0,13673578 ! translational initiation GO:0006413 66 29 0,000 0,11401178 0,13666869 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,11401178 0,13660166 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,11401178 0,1365347 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,11401178 0,1364678 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,11401178 0,13640097 ! autophagy GO:0006914 47 29 0,000 0,11401178 0,13633421 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,11401178 0,13626751 ! primary neural tube formation GO:0014020 61 29 0,000 0,11401178 0,13620087 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,11401178 0,1361343 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,11401178 0,1360678 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,11401178 0,13600136 ! synaptogenesis GO:0007416 46 29 0,000 0,11401178 0,13593498 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,11401178 0,13586867 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,11401178 0,13580243 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,11401178 0,13573625 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,11770392 0,14006365 ! phenol metabolic process GO:0018958 56 30 0,000 0,11770392 0,13999546 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,11770392 0,13992734 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,11770392 0,13985928 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,11770392 0,13979129 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,11770392 0,13972336 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,11770392 0,1396555 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,11770392 0,13958771 ! acute-phase response GO:0006953 50 30 0,000 0,11770392 0,13951998 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,11770392 0,13945232 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,11770392 0,13938472 ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,11770392 0,13931719 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,11770392 0,13924972 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,11770392 0,13918232 ! cell fate determination GO:0001709 64 30 0,000 0,11770392 0,13911499 ! phospholipid transport GO:0015914 65 30 0,000 0,11770392 0,13904772 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,11770392 0,13898051 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,11770392 0,13891337 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,11770392 0,13884629 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,12138077 0,14311449 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,12138077 0,14304546 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,12138077 0,14297649 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,12138077 0,14290758 ! regulation of innate immune response GO:0045088 57 31 0,000 0,12138077 0,14283874 ! peptide transport GO:0015833 60 31 0,000 0,12138077 0,14276997 ! iron ion homeostasis GO:0055072 60 31 0,000 0,12138077 0,14270127 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,12138077 0,14263263 ! detection of light stimulus GO:0009583 44 31 0,000 0,12138077 0,14256405 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,12138077 0,14249555 ! natural killer cell activation GO:0030101 50 31 0,000 0,12138077 0,1424271 ! ensheathment of neurons GO:0007272 64 31 0,000 0,12138077 0,14235873 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,12138077 0,14229042 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,12138077 0,14222217 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,12138077 0,14215399 ! eye morphogenesis GO:0048592 65 31 0,000 0,12138077 0,14208588 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,12138077 0,14201783 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,12504241 0,14623198 ! collagen metabolic process GO:0032963 49 32 0,000 0,12504241 0,14616201 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,12504241 0,14609211 ! spindle organization GO:0007051 50 32 0,000 0,12504241 0,14602228 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,12504241 0,14595251 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,12504241 0,14588281 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,12504241 0,14581318 ! mesoderm formation GO:0001707 73 32 0,000 0,12504241 0,14574361 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,12504241 0,14567411 ! peripheral nervous system development GO:0007422 68 32 0,000 0,12504241 0,14560467 ! BMP signaling pathway GO:0030509 71 32 0,000 0,12504241 0,14553531 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,12504241 0,145466 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,12504241 0,14539677 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,12504241 0,1453276 ! gene silencing GO:0016458 71 32 0,000 0,12504241 0,14525849 ! regulation of pH GO:0006885 56 33 0,000 0,12868889 0,14942346 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,12868889 0,14935247 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,12868889 0,14928155 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,12868889 0,1492107 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,12868889 0,14913992 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,12868889 0,1490692 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,12868889 0,14899856 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,12868889 0,14892797 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,12868889 0,14885746 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,12868889 0,14878701 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,12868889 0,14871663 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,12868889 0,14864631 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,12868889 0,14857606 ! glial cell differentiation GO:0010001 67 34 0,000 0,13232027 0,15269647 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,13232027 0,15262437 ! cholesterol transport GO:0030301 62 34 0,000 0,13232027 0,15255235 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,13232027 0,15248039 ! spliceosome assembly GO:0000245 75 34 0,000 0,13232027 0,1524085 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,13232027 0,15233667 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,13232027 0,15226492 ! formation of primary germ layer GO:0001704 76 34 0,000 0,13232027 0,15219323 ! cell fate specification GO:0001708 56 34 0,000 0,13232027 0,15212161 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,13232027 0,15205006 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,13232027 0,15197857 ! adult locomotory behavior GO:0008344 62 34 0,000 0,13232027 0,15190715 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,13593662 0,15598552 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,13593662 0,15591228 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,13593662 0,15583912 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,13593662 0,15576602 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,13593662 0,155693 ! membrane docking GO:0022406 69 35 0,000 0,13593662 0,15562004 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,13593662 0,15554715 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,13593662 0,15547433 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,13593662 0,15540157 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,13593662 0,15532889 ! ceramide metabolic process GO:0006672 72 35 0,000 0,13593662 0,15525627 ! telencephalon development GO:0021537 81 35 0,000 0,13593662 0,15518372 ! sterol transport GO:0015918 63 35 0,000 0,13593662 0,15511124 ! placenta development GO:0001890 53 35 0,000 0,13593662 0,15503883 ! vesicle localization GO:0051648 70 35 0,000 0,13593662 0,15496648 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,139538 0,15899782 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,139538 0,1589237 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,139538 0,15884964 ! protein targeting to membrane GO:0006612 75 36 0,000 0,139538 0,15877566 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,139538 0,15870174 ! aerobic respiration GO:0009060 56 36 0,000 0,139538 0,15862789 ! cytokine production GO:0001816 68 36 0,000 0,139538 0,15855411 ! embryonic organ development GO:0048568 67 36 0,000 0,139538 0,1584804 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,139538 0,15840675 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,139538 0,15833318 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,14312447 0,16232734 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,14312447 0,16225201 ! sister chromatid segregation GO:0000819 65 37 0,000 0,14312447 0,16217675 ! odontogenesis GO:0042476 74 37 0,000 0,14312447 0,16210157 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,14312447 0,16202645 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,14312447 0,1619514 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,14312447 0,16187643 ! positive regulation of DNA metabolic process GO:0051054 77 38 0,000 0,14669609 0,16583922 ! meiosis I GO:0007127 74 38 0,000 0,14669609 0,16576251 ! organic anion transport GO:0015711 82 38 0,000 0,14669609 0,16568588 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,14669609 0,16560931 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,14669609 0,16553282 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,14669609 0,1654564 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,14669609 0,16538004 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,14669609 0,16530376 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,14669609 0,16522755 ! spermatid development GO:0007286 69 38 0,000 0,14669609 0,16515141 ! glycogen metabolic process GO:0005977 63 38 0,000 0,14669609 0,16507533 ! neural tube formation GO:0001841 79 38 0,000 0,14669609 0,16499933 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,15025293 0,16892218 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,15025293 0,16884448 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,15025293 0,16876685 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,15025293 0,16868929 GO:0042593|glucose homeostasis, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,15025293 0,16861181 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,15025293 0,16853439 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,15025293 0,16845704 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,15025293 0,16837977 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,15025293 0,16830257 ! glucan metabolic process GO:0044042 64 39 0,000 0,15025293 0,16822544 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,15379504 0,17211236 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,15379504 0,17203355 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,15379504 0,17195482 ! learning GO:0007612 82 40 0,000 0,15379504 0,17187615 ! lipid homeostasis GO:0055088 75 40 0,000 0,15379504 0,17179756 ! mismatch repair GO:0006298 58 40 0,000 0,15379504 0,17171905 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,15379504 0,1716406 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,15379504 0,17156222 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,15379504 0,17148392 ! RNA export from nucleus GO:0006405 61 41 0,000 0,15732248 0,17533705 ! mRNA catabolic process GO:0006402 79 41 0,000 0,15732248 0,1752571 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,15732248 0,17517722 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,15732248 0,17509741 ! establishment or maintenance of cell polarity GO:0007163 96 41 0,000 0,15732248 0,17501767 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,15732248 0,17493801 ! gliogenesis GO:0042063 91 41 0,000 0,15732248 0,17485842 ! feeding behavior GO:0007631 69 41 0,000 0,15732248 0,17477891 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,15732248 0,17469946 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,15732248 0,17462009 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,15732248 0,17454079 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,15732248 0,17446156 ! RNA modification GO:0009451 64 41 0,000 0,15732248 0,1743824 ! ear morphogenesis GO:0042471 64 42 0,000 0,16083532 0,17819532 ! organic ether metabolic process GO:0018904 59 42 0,000 0,16083532 0,17811454 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,16083532 0,17803384 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,16083532 0,1779532 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,16083532 0,17787265 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,16083532 0,17779216 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,16083532 0,17771175 ! cytokinesis GO:0000910 84 42 0,000 0,16083532 0,17763141 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,16083532 0,17755114 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,16433361 0,18133108 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,16433361 0,18124921 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,16433361 0,18116742 ! regulation of tube size GO:0035150 76 43 0,000 0,16433361 0,1810857 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,16433361 0,18100406 ! glucose transport GO:0015758 66 43 0,000 0,16433361 0,18092249 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,16433361 0,18084099 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,16433361 0,18075957 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,16433361 0,18067822 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,16433361 0,18059694 ! ion transmembrane transport GO:0034220 79 43 0,000 0,16433361 0,18051574 ! neuron migration GO:0001764 85 43 0,000 0,16433361 0,18043461 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,16433361 0,18035355 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,16781741 0,18409427 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,16781741 0,18401164 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,16781741 0,18392909 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,16781741 0,18384661 ! hexose transport GO:0008645 68 44 0,000 0,16781741 0,18376421 GO:0015749|monosaccharide transport, ! striated muscle contraction GO:0006941 85 44 0,000 0,16781741 0,18368187 ! phagocytosis GO:0006909 105 44 0,000 0,16781741 0,18359962 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,16781741 0,18351743 ! double-strand break repair GO:0006302 85 44 0,000 0,16781741 0,18343532 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,1712868 0,18714385 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,1712868 0,18706019 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,1712868 0,18697661 ! biopolymer methylation GO:0043414 91 45 0,000 0,1712868 0,1868931 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,1712868 0,18680966 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,1712868 0,1867263 ! polyol metabolic process GO:0019751 77 45 0,000 0,1712868 0,18664302 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,17474181 0,19032289 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,17474181 0,19023808 ! glycolysis GO:0006096 71 46 0,000 0,17474181 0,19015334 ! leukocyte migration GO:0050900 75 46 0,000 0,17474181 0,19006867 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,17474181 0,18998409 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,17474181 0,18989957 ! neural tube development GO:0021915 91 47 0,000 0,17818252 0,19355264 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,17818252 0,19346662 ! positive regulation of defense response GO:0031349 88 48 0,000 0,18160898 0,19709939 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,18160898 0,19701187 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,18160898 0,19692442 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,18160898 0,19683706 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,18160898 0,19674977 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,18160898 0,19666256 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,18160898 0,19657542 ! methylation GO:0032259 97 48 0,000 0,18160898 0,19648836 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,18502124 0,20009159 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,18502124 0,20000305 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,18502124 0,19991459 ! JNK cascade GO:0007254 106 49 0,000 0,18502124 0,19982621 ! protein homooligomerization GO:0051260 84 49 0,000 0,18502124 0,19973791 ! regulation of action potential GO:0001508 102 50 0,000 0,18841938 0,2033165 ! regulation of ion transport GO:0043269 86 50 0,000 0,18841938 0,20322673 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,18841938 0,20313705 ! endocrine system development GO:0035270 109 50 0,000 0,18841938 0,20304744 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,18841938 0,20295791 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,18841938 0,20286846 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,18841938 0,20277909 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,18841938 0,2026898 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,18841938 0,20260059 ! regulation of cell projection organization GO:0031344 135 51 0,000 0,19180344 0,20614862 ! viral infectious cycle GO:0019058 104 51 0,000 0,19180344 0,20605796 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,19180344 0,20596739 ! peptide metabolic process GO:0006518 80 51 0,000 0,19180344 0,20587689 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,19180344 0,20578648 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,19180344 0,20569614 ! Notch signaling pathway GO:0007219 111 52 0,000 0,19517349 0,20921845 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,19517349 0,20912668 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,19517349 0,209035 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,19517349 0,2089434 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,19517349 0,20885188 ! excretion GO:0007588 87 52 0,000 0,19517349 0,20876044 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,19517349 0,20866908 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,19517349 0,20857779 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,19517349 0,20848659 ! amino acid activation GO:0043038 98 52 0,000 0,19517349 0,20839547 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,19852958 0,21188631 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,19852958 0,21179378 ! synapse organization GO:0050808 102 53 0,000 0,19852958 0,21170134 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,20187177 0,21517135 ! regulation of translational initiation GO:0006446 87 54 0,000 0,20187177 0,21507751 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,20187177 0,21498375 ! neuromuscular process GO:0050905 107 54 0,000 0,20187177 0,21489008 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,20187177 0,21479649 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,20187177 0,21470297 ! membrane fusion GO:0006944 122 54 0,000 0,20187177 0,21460954 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,20187177 0,21451619 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,20187177 0,21442293 ! regulation of cell shape GO:0008360 142 54 0,000 0,20187177 0,21432974 ! RNA catabolic process GO:0006401 103 55 0,000 0,20520011 0,21776884 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,20520011 0,21767428 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,20520011 0,21757981 ! cell recognition GO:0008037 98 55 0,000 0,20520011 0,21748541 ! cell maturation GO:0048469 107 55 0,000 0,20520011 0,2173911 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,20520011 0,21729687 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,20851467 0,22071115 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,20851467 0,22061557 ! glucose catabolic process GO:0006007 88 56 0,000 0,20851467 0,22052006 ! regulation of DNA replication GO:0006275 105 56 0,000 0,20851467 0,22042464 ! RNA elongation GO:0006354 90 56 0,000 0,20851467 0,2203293 ! chloride transport GO:0006821 102 57 0,000 0,2118155 0,22372039 ! muscle fiber development GO:0048747 131 57 0,000 0,2118155 0,22362371 ! heart morphogenesis GO:0003007 105 57 0,000 0,2118155 0,22352712 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,2118155 0,2234306 ! regulation of actin filament length GO:0030832 118 58 0,000 0,21510266 0,22680008 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,21510266 0,22670224 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,21510266 0,22660448 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,21510266 0,22650681 ! gastrulation GO:0007369 122 58 0,000 0,21510266 0,22640922 ! nuclear export GO:0051168 110 59 0,000 0,2183762 0,22975584 ! establishment of organelle localization GO:0051656 122 59 0,000 0,2183762 0,22965693 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,22163618 0,23298502 ! regulation of endocytosis GO:0030100 104 60 0,000 0,22163618 0,23288481 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,22163618 0,23278468 ! adult behavior GO:0030534 104 60 0,000 0,22163618 0,23268465 ! positive regulation of secretion GO:0051047 110 61 0,000 0,22488265 0,23599154 ! regulation of cellular component size GO:0032535 125 61 0,000 0,22488265 0,23589021 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,22488265 0,23578897 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,22488265 0,23568782 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,22488265 0,23558675 ! regulation of heart contraction GO:0008016 123 61 0,000 0,22488265 0,23548577 ! camera-type eye development GO:0043010 126 61 0,000 0,22488265 0,23538488 ! proton transport GO:0015992 117 61 0,000 0,22488265 0,23528407 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,22488265 0,23518335 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,22811567 0,23846238 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,22811567 0,23836039 ! tRNA processing GO:0008033 102 62 0,000 0,22811567 0,23825848 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,2313353 0,24151801 ! mesoderm development GO:0007498 128 63 0,000 0,2313353 0,24141484 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,2313353 0,24131176 ! hydrogen transport GO:0006818 121 64 0,000 0,23454159 0,2445519 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,23454159 0,24444757 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,23454159 0,24434333 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,2377346 0,2475642 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,2377346 0,24745872 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,2377346 0,24735333 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,24091437 0,25055505 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,24091437 0,25044843 ! chromosome segregation GO:0007059 127 67 0,000 0,24408097 0,25363242 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,24408097 0,25352458 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,24408097 0,25341684 ! myeloid cell differentiation GO:0030099 126 67 0,000 0,24408097 0,25330918 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,24723445 0,25647294 ! hexose catabolic process GO:0019320 113 68 0,000 0,24723445 0,25636408 ! extracellular matrix organization GO:0030198 146 68 0,000 0,24723445 0,25625531 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,24723445 0,25614664 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,24723445 0,25603805 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,24723445 0,25592956 ! adaptive immune response GO:0002250 126 68 0,000 0,24723445 0,25582117 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 0,000 0,24723445 0,25571286 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,25037487 0,25885138 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,25037487 0,25874188 ! developmental maturation GO:0021700 128 69 0,000 0,25037487 0,25863247 ! single fertilization GO:0007338 83 69 0,000 0,25037487 0,25852316 ! cell redox homeostasis GO:0045454 114 70 0,000 0,25350227 0,26164176 ! activation of immune response GO:0002253 120 70 0,000 0,25350227 0,26153127 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,25350227 0,26142087 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,25661671 0,26452094 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,25661671 0,26440937 ! carbohydrate transport GO:0008643 114 72 0,000 0,25971824 0,26749227 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,25971824 0,26737955 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,25971824 0,26726692 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,25971824 0,26715439 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,26280692 0,27021772 ! regulation of immune effector process GO:0002697 156 73 0,000 0,26280692 0,27010404 ! acute inflammatory response GO:0002526 118 74 0,000 0,2658828 0,27315042 ! amino acid transport GO:0006865 148 74 0,000 0,2658828 0,2730356 ! organelle localization GO:0051640 155 74 0,000 0,2658828 0,27292088 ! transition metal ion transport GO:0000041 143 75 0,000 0,26894594 0,27594915 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,26894594 0,2758333 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,26894594 0,27571755 ! eye development GO:0001654 155 75 0,000 0,26894594 0,2756019 ! axon guidance GO:0007411 162 75 0,000 0,26894594 0,27548634 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,27199638 0,27849419 ! learning or memory GO:0007611 161 76 0,000 0,27199638 0,27837752 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,27199638 0,27826095 ! regulation of blood pressure GO:0008217 134 76 0,000 0,27199638 0,27814447 ! amine catabolic process GO:0009310 136 77 0,000 0,27503417 0,28113326 ! neurotransmitter transport GO:0006836 142 77 0,000 0,27503417 0,28101568 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,27503417 0,28089819 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,27503417 0,28078081 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,27503417 0,28066353 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,27805938 0,28363217 ! antigen processing and presentation GO:0019882 117 78 0,000 0,27805938 0,2835138 ! fertilization GO:0009566 99 78 0,000 0,27805938 0,28339552 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,28107204 0,28634654 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,28107204 0,28622718 ! protein oligomerization GO:0051259 149 79 0,000 0,28107204 0,28610792 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,28107204 0,28598876 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,28407222 0,28892108 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,28705996 0,29183832 ! protein import into nucleus GO:0006606 174 82 0,000 0,29003532 0,29474055 ! exocytosis GO:0006887 153 83 0,000 0,29299835 0,29762784 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,29299835 0,29750414 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,29299835 0,29738054 ! nuclear import GO:0051170 177 83 0,000 0,29299835 0,29725704 ! inorganic anion transport GO:0015698 156 83 0,000 0,29299835 0,29713365 ! digestion GO:0007586 130 84 0,000 0,29594909 0,3000015 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,2988876 0,30285458 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,2988876 0,30272902 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,30472812 0,3085167 ! alcohol catabolic process GO:0046164 142 87 0,000 0,30472812 0,3083889 ! nucleosome assembly GO:0006334 126 87 0,000 0,30472812 0,3082612 ! cellular respiration GO:0045333 143 88 0,000 0,30763023 0,31106815 ! sensory perception of smell GO:0007608 117 88 0,000 0,30763023 0,31093945 ! chromatin assembly GO:0031497 128 88 0,000 0,30763023 0,31081086 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,30763023 0,31068237 ! cellular defense response GO:0006968 123 89 0,000 0,31052032 0,31347154 ! protein localization in nucleus GO:0034504 192 89 0,000 0,31052032 0,31334206 ! regulation of neurological system process GO:0031644 175 89 0,000 0,31052032 0,31321269 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,31339841 0,31598528 ! response to unfolded protein GO:0006986 139 90 0,000 0,31339841 0,31585492 ! defense response to bacterium GO:0042742 112 91 0,000 0,31626458 0,31861211 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,31911886 0,32135506 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,32196131 0,32408384 ! amine transport GO:0015837 181 93 0,000 0,32196131 0,32395036 ! vitamin metabolic process GO:0006766 153 93 0,000 0,32196131 0,32381699 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,32479197 0,32652954 ! sterol metabolic process GO:0016125 166 94 0,000 0,32479197 0,32639522 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,32479197 0,32626101 ! regulation of defense response GO:0031347 171 95 0,000 0,32761089 0,32895742 ! nucleosome organization GO:0034728 143 95 0,000 0,32761089 0,32882227 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,32761089 0,32868723 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,32761089 0,3285523 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,32761089 0,32841748 ! regulation of T cell activation GO:0050863 175 96 0,000 0,33041812 0,33109576 ! regulation of DNA metabolic process GO:0051052 188 97 0,000 0,33321371 0,33376019 ! transcription initiation GO:0006352 171 97 0,000 0,33321371 0,3336234 ! mRNA transport GO:0051028 185 100 0,000 0,34153112 0,34181095 ! positive regulation of immune response GO:0050778 175 100 0,000 0,34153112 0,34167097 ! hormone metabolic process GO:0042445 171 100 0,000 0,34153112 0,34153112