pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1203-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of protein kinase activity GO:0006469 99 57 8,000 2,289E-10 5,264E-07 ! negative regulation of kinase activity GO:0033673 100 58 8,000 2,693E-10 3,097E-07 ! negative regulation of transferase activity GO:0051348 105 61 8,000 4,308E-10 3,303E-07 ! regulation of endothelial cell proliferation GO:0001936 46 24 5,000 1,367E-08 7,859E-06 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 6,000 1,985E-08 9,133E-06 ! gas homeostasis GO:0033483 11 6 3,000 3,577E-08 1,371E-05 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 3,000 1,651E-07 5,425E-05 ! interphase of mitotic cell cycle GO:0051329 156 86 7,000 1,705E-07 4,902E-05 ! interphase GO:0051325 159 88 7,000 2,041E-07 5,216E-05 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 4,000 2,357E-07 5,421E-05 ! vasculogenesis GO:0001570 33 22 4,000 3,958E-07 8,276E-05 ! negative regulation of MAPKKK cascade GO:0043409 20 10 3,000 4,899E-07 9,39E-05 ! protein amino acid autophosphorylation GO:0046777 80 45 5,000 7,324E-07 1,296E-04 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 3,000 7,657E-07 1,258E-04 ! response to hypoxia GO:0001666 132 72 6,000 7,657E-07 1,174E-04 ! response to oxygen levels GO:0070482 137 74 6,000 9,245E-07 1,329E-04 ! negative regulation of protein kinase cascade GO:0010741 51 26 4,000 9,665E-07 1,308E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 5,000 1,564E-06 1,999E-04 ! regulation of monooxygenase activity GO:0032768 26 13 3,000 1,641E-06 1,986E-04 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 3,000 2,284E-06 2,627E-04 ! peptidyl-histidine phosphorylation GO:0018106 7 5 2,000 3,447E-06 3,776E-04 ! positive regulation of vasoconstriction GO:0045907 9 5 2,000 3,447E-06 3,604E-04 ! positive regulation of microtubule polymerization GO:0031116 9 5 2,000 3,447E-06 3,447E-04 ! peptidyl-amino acid modification GO:0018193 147 93 6,000 4,355E-06 4,173E-04 ! tissue remodeling GO:0048771 62 36 4,000 5,234E-06 4,815E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 6,832E-06 6,043E-04 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 2,000 6,859E-06 5,843E-04 ! peptidyl-histidine modification GO:0018202 9 6 2,000 6,859E-06 5,634E-04 ! regulation of epidermal cell differentiation GO:0045604 7 6 2,000 6,859E-06 5,44E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 6,859E-06 5,258E-04 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 2,000 6,859E-06 5,089E-04 ! regulation of microtubule polymerization GO:0031113 11 6 2,000 6,859E-06 4,93E-04 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 3,000 8,606E-06 5,998E-04 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 3,000 8,606E-06 5,822E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 8,93E-06 5,868E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 1,194E-05 7,629E-04 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 1,194E-05 7,422E-04 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 2,000 1,194E-05 7,227E-04 ! positive regulation of monooxygenase activity GO:0032770 11 7 2,000 1,194E-05 7,042E-04 ! positive regulation of epidermis development GO:0045684 11 7 2,000 1,194E-05 6,866E-04 ! regulation of cell-matrix adhesion GO:0001952 51 22 3,000 1,598E-05 8,962E-04 GO:0010810|regulation of cell-substrate adhesion, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 1,901E-05 1,041E-03 ! UTP metabolic process GO:0046051 8 8 2,000 1,901E-05 1,017E-03 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 1,901E-05 9,935E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,901E-05 9,714E-04 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 2,000 1,901E-05 9,503E-04 ! cellular iron ion homeostasis GO:0006879 37 23 3,000 1,923E-05 9,412E-04 ! regulation of protein polymerization GO:0032271 71 47 4,000 2,001E-05 9,587E-04 ! regulation of oxidoreductase activity GO:0051341 39 24 3,000 2,295E-05 1,077E-03 ! iron ion homeostasis GO:0055072 39 25 3,000 2,718E-05 1,25E-03 ! regulation of epithelial cell differentiation GO:0030856 13 9 2,000 2,836E-05 1,279E-03 ! CTP metabolic process GO:0046036 9 9 2,000 2,836E-05 1,254E-03 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 2,000 2,836E-05 1,231E-03 ! GTP metabolic process GO:0046039 9 9 2,000 2,836E-05 1,208E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 2,836E-05 1,186E-03 ! positive regulation of protein polymerization GO:0032273 15 9 2,000 2,836E-05 1,165E-03 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 3,000 3,194E-05 1,289E-03 ! cell cycle arrest GO:0007050 150 86 5,000 3,336E-05 1,323E-03 ! regulation of protein complex assembly GO:0043254 81 54 4,000 3,965E-05 1,546E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 4,03E-05 1,545E-03 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 2,000 4,03E-05 1,52E-03 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of bone resorption GO:0045124 24 10 2,000 4,03E-05 1,495E-03 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 2,000 4,03E-05 1,471E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 3,000 4,327E-05 1,555E-03 ! regulation of lipid metabolic process GO:0019216 84 56 4,000 4,735E-05 1,675E-03 ! regulation of cytoskeleton organization GO:0051493 154 93 5,000 5,194E-05 1,81E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 5,513E-05 1,893E-03 ! regulation of microtubule-based process GO:0032886 58 30 3,000 5,728E-05 1,938E-03 ! regulation of homeostatic process GO:0032844 105 60 4,000 6,619E-05 2,206E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 7,313E-05 2,403E-03 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 2,000 7,313E-05 2,369E-03 ! gland morphogenesis GO:0022612 23 12 2,000 7,313E-05 2,336E-03 ! peptidyl-lysine modification GO:0018205 18 12 2,000 7,313E-05 2,304E-03 ! regulation of epidermis development GO:0045682 17 12 2,000 7,313E-05 2,273E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 2,000 7,313E-05 2,243E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 9,033E-05 2,734E-03 ! positive regulation of protein complex assembly GO:0031334 19 13 2,000 9,458E-05 2,825E-03 ! lipid localization GO:0010876 24 13 2,000 9,458E-05 2,789E-03 GO:0019915|lipid storage, ! glycogen metabolic process GO:0005977 48 35 3,000 1,065E-04 3,1E-03 ! glucan metabolic process GO:0044042 49 36 3,000 1,191E-04 3,425E-03 GO:0006073|cellular glucan metabolic process, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 2,000 1,197E-04 3,4E-03 ! muscle maintenance GO:0046716 19 14 2,000 1,197E-04 3,359E-03 ! epithelial to mesenchymal transition GO:0001837 22 14 2,000 1,197E-04 3,318E-03 ! ribonucleoside metabolic process GO:0009119 48 37 3,000 1,329E-04 3,638E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 1,489E-04 4,029E-03 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 2,000 1,489E-04 3,982E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 1,489E-04 3,937E-03 ! regulation of vasodilation GO:0042312 24 15 2,000 1,489E-04 3,892E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 1,489E-04 3,848E-03 ! positive regulation of oxidoreductase activity GO:0051353 21 15 2,000 1,489E-04 3,805E-03 ! regulation of peptidase activity GO:0052547 106 72 4,000 1,584E-04 4,005E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,637E-04 4,092E-03 ! mitochondrion organization GO:0007005 104 73 4,000 1,691E-04 4,183E-03 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 2,000 1,823E-04 4,461E-03 ! G1 phase GO:0051318 27 16 2,000 1,823E-04 4,414E-03 ! negative regulation of growth GO:0045926 123 75 4,000 1,922E-04 4,604E-03 ! energy reserve metabolic process GO:0006112 59 41 3,000 1,993E-04 4,726E-03 ! positive regulation of DNA binding GO:0043388 57 41 3,000 1,993E-04 4,678E-03 ! regulation of DNA binding GO:0051101 119 77 4,000 2,175E-04 5,054E-03 ! cellular component disassembly GO:0022411 64 42 3,000 2,191E-04 5,039E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,202E-04 5,016E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 2,202E-04 4,966E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 2,202E-04 4,918E-03 ! positive regulation of binding GO:0051099 59 43 3,000 2,402E-04 5,313E-03 ! positive regulation of anti-apoptosis GO:0045768 29 18 2,000 2,629E-04 5,759E-03 ! positive regulation of cytoskeleton organization GO:0051495 33 18 2,000 2,629E-04 5,705E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 3,106E-04 6,677E-03 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 3,106E-04 6,615E-03 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 2,000 3,106E-04 6,554E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 3,106E-04 6,495E-03 ! regulation of endothelial cell migration GO:0010594 40 19 2,000 3,106E-04 6,436E-03 ! regulation of fatty acid metabolic process GO:0019217 28 19 2,000 3,106E-04 6,379E-03 ! response to UV GO:0009411 75 46 3,000 3,125E-04 6,361E-03 ! transcription initiation GO:0006352 118 85 4,000 3,452E-04 6,965E-03 ! cellular polysaccharide metabolic process GO:0044264 63 48 3,000 3,686E-04 7,372E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 4,219E-04 8,366E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 4,219E-04 8,295E-03 ! regulation of vasoconstriction GO:0019229 31 21 2,000 4,219E-04 8,224E-03 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 2,000 4,219E-04 8,155E-03 ! positive regulation of cell migration GO:0030335 92 51 3,000 4,657E-04 8,925E-03 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 4,86E-04 9,239E-03 ! regulation of anti-apoptosis GO:0045767 36 22 2,000 4,86E-04 9,163E-03 ! regulation of smooth muscle contraction GO:0006940 36 22 2,000 4,86E-04 9,089E-03 ! membrane depolarization GO:0051899 35 22 2,000 4,86E-04 9,015E-03 ! regulation of blood coagulation GO:0030193 34 22 2,000 4,86E-04 8,943E-03 ! neural tube closure GO:0001843 33 22 2,000 4,86E-04 8,872E-03 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! negative regulation of bone resorption GO:0045779 10 5 1,000 4,921E-04 8,913E-03 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 4,921E-04 8,843E-03 ! transcription from mitochondrial promoter GO:0006390 6 5 1,000 4,921E-04 8,775E-03 ! embryonic hemopoiesis GO:0035162 10 5 1,000 4,921E-04 8,707E-03 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 1,000 4,921E-04 8,641E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 4,921E-04 8,575E-03 ! anagen GO:0042640 6 5 1,000 4,921E-04 8,511E-03 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 1,000 4,921E-04 8,447E-03 GO:0046516|hypusine metabolic process, ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 4,921E-04 8,385E-03 ! microvillus organization GO:0032528 7 5 1,000 4,921E-04 8,323E-03 GO:0030033|microvillus assembly, ! response to food GO:0032094 5 5 1,000 4,921E-04 8,262E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 4,921E-04 8,202E-03 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 4,921E-04 8,143E-03 GO:0045686|negative regulation of glial cell differentiation, ! forebrain morphogenesis GO:0048853 13 5 1,000 4,921E-04 8,085E-03 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 1,000 4,921E-04 8,028E-03 ! respiratory chain complex IV assembly GO:0008535 9 5 1,000 4,921E-04 7,971E-03 ! positive regulation of chemokine production GO:0032722 7 5 1,000 4,921E-04 7,916E-03 ! transcription termination GO:0006353 8 5 1,000 4,921E-04 7,861E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 4,921E-04 7,806E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 4,921E-04 7,753E-03 GO:0022011|myelination in the peripheral nervous system, ! negative regulation of phosphorylation GO:0042326 41 23 2,000 5,561E-04 8,7E-03 ! regulation of binding GO:0051098 151 95 4,000 5,764E-04 8,957E-03 ! regulation of cellular component biogenesis GO:0044087 158 96 4,000 6,046E-04 9,333E-03 ! response to light stimulus GO:0009416 153 96 4,000 6,046E-04 9,271E-03 ! nucleoside metabolic process GO:0009116 69 55 3,000 6,218E-04 9,471E-03 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 6,322E-04 9,566E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 6,322E-04 9,504E-03 ! primary neural tube formation GO:0014020 35 24 2,000 6,322E-04 9,442E-03 ! positive regulation of cell motion GO:0051272 99 56 3,000 6,66E-04 9,883E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 7,147E-04 0,01053764 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 2,000 7,147E-04 0,01047052 ! regulation of translation GO:0006417 151 100 4,000 7,282E-04 0,01060012 ! male meiosis GO:0007140 7 6 1,000 7,348E-04 0,01062909 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 7,348E-04 0,01056266 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 7,348E-04 0,01049705 ! mRNA stabilization GO:0048255 15 6 1,000 7,348E-04 0,01043226 GO:0043489|RNA stabilization, ! ER overload response GO:0006983 7 6 1,000 7,348E-04 0,01036825 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 7,348E-04 0,01030503 ! astrocyte development GO:0014002 14 6 1,000 7,348E-04 0,01024258 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 7,348E-04 0,01018088 ! hair follicle maturation GO:0048820 7 6 1,000 7,348E-04 0,01011991 ! Schwann cell development GO:0014044 14 6 1,000 7,348E-04 0,01005968 ! coenzyme A metabolic process GO:0015936 9 6 1,000 7,348E-04 0,01000015 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 7,348E-04 9,941E-03 ! negative regulation of B cell activation GO:0050869 9 6 1,000 7,348E-04 9,883E-03 ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 7,61E-04 0,01017599 ! regulation of coagulation GO:0050818 39 26 2,000 8,038E-04 0,01068617 ! negative regulation of cell growth GO:0030308 106 62 3,000 9,79E-04 0,0129408 ! cholesterol homeostasis GO:0042632 46 28 2,000 1,002E-03 0,01317382 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 34 28 2,000 1,002E-03 0,01309897 ! neural tube formation GO:0001841 41 28 2,000 1,002E-03 0,01302497 ! positive regulation of catabolic process GO:0009896 40 28 2,000 1,002E-03 0,01295179 ! placenta development GO:0001890 37 28 2,000 1,002E-03 0,01287944 ! regulation of B cell activation GO:0050864 42 28 2,000 1,002E-03 0,01280788 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,024E-03 0,01301133 ! microtubule bundle formation GO:0001578 8 7 1,000 1,024E-03 0,01293984 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,024E-03 0,01286913 ! hemoglobin metabolic process GO:0020027 10 7 1,000 1,024E-03 0,01279919 ! adrenal gland development GO:0030325 17 7 1,000 1,024E-03 0,01273 ! vesicle fusion GO:0006906 15 7 1,000 1,024E-03 0,01266156 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 1,000 1,024E-03 0,01259385 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,024E-03 0,01252686 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 1,000 1,024E-03 0,01246059 ! ATP catabolic process GO:0006200 10 7 1,000 1,024E-03 0,012395 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 3,000 1,04E-03 0,01251989 ! cell cycle checkpoint GO:0000075 108 64 3,000 1,103E-03 0,01321285 ! regulation of MAPKKK cascade GO:0043408 101 65 3,000 1,169E-03 0,01393027 ! protein oligomerization GO:0051259 100 65 3,000 1,169E-03 0,01385846 ! cholesterol transport GO:0030301 46 30 2,000 1,229E-03 0,01450146 GO:0015918|sterol transport, ! embryonic epithelial tube formation GO:0001838 44 30 2,000 1,229E-03 0,01442747 ! mammary gland development GO:0030879 57 31 2,000 1,354E-03 0,01581036 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,359E-03 0,01578534 ! induction of positive chemotaxis GO:0050930 14 8 1,000 1,359E-03 0,01570601 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,359E-03 0,01562748 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,359E-03 0,01554973 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 1,000 1,359E-03 0,01547276 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! astrocyte differentiation GO:0048708 16 8 1,000 1,359E-03 0,01539653 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,359E-03 0,01532106 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,359E-03 0,01524632 ! Schwann cell differentiation GO:0014037 17 8 1,000 1,359E-03 0,01517231 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,359E-03 0,01509902 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 1,000 1,359E-03 0,01502643 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,359E-03 0,01495453 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,359E-03 0,01488332 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 1,000 1,359E-03 0,01481278 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 1,000 1,359E-03 0,01474291 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 1,359E-03 0,01467369 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,359E-03 0,01460512 ! branched chain family amino acid catabolic process GO:0009083 11 8 1,000 1,359E-03 0,01453719 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,359E-03 0,01446989 ! neutral lipid metabolic process GO:0006638 41 32 2,000 1,487E-03 0,01575648 GO:0006639|acylglycerol metabolic process, ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 3,000 1,541E-03 0,01625366 ! negative regulation of cell adhesion GO:0007162 67 33 2,000 1,627E-03 0,01708548 ! nucleus organization GO:0006997 49 33 2,000 1,627E-03 0,01700782 ! lipid homeostasis GO:0055088 55 33 2,000 1,627E-03 0,01693086 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,627E-03 0,01685459 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 2,000 1,627E-03 0,01677901 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,739E-03 0,01785651 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 1,739E-03 0,01777715 ! artery development GO:0060840 19 9 1,000 1,739E-03 0,01769849 GO:0048844|artery morphogenesis, ! regulation of glycolysis GO:0006110 15 9 1,000 1,739E-03 0,01762052 ! protein complex disassembly GO:0043241 17 9 1,000 1,739E-03 0,01754324 GO:0043624|cellular protein complex disassembly, ! lung alveolus development GO:0048286 17 9 1,000 1,739E-03 0,01746663 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 1,739E-03 0,01739069 ! protein targeting to ER GO:0045047 19 9 1,000 1,739E-03 0,01731541 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 1,000 1,739E-03 0,01724077 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 1,739E-03 0,01716678 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 1,739E-03 0,01709341 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 1,739E-03 0,01702068 ! embryonic placenta development GO:0001892 12 9 1,000 1,739E-03 0,01694855 ! localization within membrane GO:0051668 15 9 1,000 1,739E-03 0,01687704 ! glycerol ether metabolic process GO:0006662 44 34 2,000 1,775E-03 0,01715425 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 1,775E-03 0,01708248 ! protein import into nucleus GO:0006606 118 74 3,000 1,892E-03 0,01812878 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 1,932E-03 0,01843363 ! protein homooligomerization GO:0051260 52 35 2,000 1,932E-03 0,01835746 ! nuclear import GO:0051170 121 75 3,000 1,987E-03 0,01881122 ! organic ether metabolic process GO:0018904 46 36 2,000 2,096E-03 0,01976006 ! neural tube development GO:0021915 50 36 2,000 2,096E-03 0,01967941 ! negative regulation of muscle development GO:0048635 12 10 1,000 2,164E-03 0,02023028 ! blood vessel remodeling GO:0001974 21 10 1,000 2,164E-03 0,02014837 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 2,164E-03 0,02006713 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,164E-03 0,01998654 ! glucan biosynthetic process GO:0009250 13 10 1,000 2,164E-03 0,01990659 GO:0005978|glycogen biosynthetic process, ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 2,164E-03 0,01982728 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 2,164E-03 0,0197486 ! purine ribonucleotide catabolic process GO:0009154 14 10 1,000 2,164E-03 0,01967055 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 2,164E-03 0,0195931 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,164E-03 0,01951627 GO:0043470|regulation of carbohydrate catabolic process, ! gland development GO:0048732 148 77 3,000 2,189E-03 0,01966595 ! mesenchymal cell development GO:0014031 64 38 2,000 2,451E-03 0,02193861 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 2,000 2,451E-03 0,02185358 ! protein localization in nucleus GO:0034504 133 80 3,000 2,517E-03 0,02235053 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 2,632E-03 0,02328612 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,632E-03 0,0231969 ! ribonucleotide catabolic process GO:0009261 16 11 1,000 2,632E-03 0,02310836 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 2,632E-03 0,0230205 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 2,632E-03 0,0229333 ! nucleoside triphosphate catabolic process GO:0009143 15 11 1,000 2,632E-03 0,02284676 ! T cell homeostasis GO:0043029 20 11 1,000 2,632E-03 0,02276087 ! regulation of leukocyte migration GO:0002685 24 11 1,000 2,632E-03 0,02267562 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 2,632E-03 0,02259101 GO:0042130|negative regulation of T cell proliferation, ! negative regulation of protein complex disassembly GO:0043242 67 39 2,000 2,642E-03 0,02258999 ! morphogenesis of embryonic epithelium GO:0016331 60 39 2,000 2,642E-03 0,02250632 ! regulation of actin filament polymerization GO:0030833 59 40 2,000 2,842E-03 0,02411692 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 2,842E-03 0,02402825 ! JAK-STAT cascade GO:0007259 53 40 2,000 2,842E-03 0,02394024 ! regulation of cell adhesion GO:0030155 159 83 3,000 2,877E-03 0,02415092 ! regulation of membrane potential GO:0042391 128 85 3,000 3,136E-03 0,02622801 ! negative regulation of multicellular organismal process GO:0051241 133 85 3,000 3,136E-03 0,02613298 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 3,144E-03 0,02610697 ! heart looping GO:0001947 15 12 1,000 3,144E-03 0,02601306 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 3,144E-03 0,02591982 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! cotranslational protein targeting to membrane GO:0006613 20 12 1,000 3,144E-03 0,02582725 ! histone acetylation GO:0016573 23 12 1,000 3,144E-03 0,02573534 ! autonomic nervous system development GO:0048483 23 12 1,000 3,144E-03 0,02564408 ! regulation of mRNA stability GO:0043488 27 12 1,000 3,144E-03 0,02555346 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 3,268E-03 0,02646605 ! regulation of JAK-STAT cascade GO:0046425 61 42 2,000 3,268E-03 0,02637319 ! regulation of cell shape GO:0008360 78 42 2,000 3,268E-03 0,02628098 ! skeletal muscle tissue development GO:0007519 123 87 3,000 3,41E-03 0,02732968 GO:0060538|skeletal muscle organ development, ! activation of caspase activity GO:0006919 65 43 2,000 3,495E-03 0,02791196 ! vesicle organization GO:0016050 79 43 2,000 3,495E-03 0,02781538 ! response to insulin stimulus GO:0032868 63 43 2,000 3,495E-03 0,02771946 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 3,495E-03 0,02762421 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 3,699E-03 0,0291333 ! regulation of chemokine production GO:0032642 17 13 1,000 3,699E-03 0,02903386 ! organelle fusion GO:0048284 28 13 1,000 3,699E-03 0,02893511 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 3,699E-03 0,02883702 ! regulation of RNA stability GO:0043487 28 13 1,000 3,699E-03 0,0287396 ! lymphocyte homeostasis GO:0002260 24 13 1,000 3,699E-03 0,02864284 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 3,732E-03 0,02880069 ! positive regulation of cell cycle GO:0045787 77 45 2,000 3,978E-03 0,03059704 ! regulation of translational initiation GO:0006446 64 45 2,000 3,978E-03 0,03049505 ! regulation of protein complex disassembly GO:0043244 77 46 2,000 4,233E-03 0,03234764 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 4,295E-03 0,03271139 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,295E-03 0,03260343 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 4,295E-03 0,03249619 ! gene silencing by RNA GO:0031047 20 14 1,000 4,295E-03 0,03238964 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 4,295E-03 0,03228379 GO:0031114|regulation of microtubule depolymerization, ! G1/S transition checkpoint GO:0031575 33 14 1,000 4,295E-03 0,03217863 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 4,295E-03 0,03207416 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 4,295E-03 0,03197036 ! polysaccharide metabolic process GO:0005976 129 93 3,000 4,33E-03 0,03212797 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 2,000 4,499E-03 0,03327083 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 4,499E-03 0,03316419 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 2,000 4,499E-03 0,03305823 ! angiogenesis GO:0001525 149 95 3,000 4,671E-03 0,03421241 ! positive regulation of caspase activity GO:0043280 72 48 2,000 4,774E-03 0,03485881 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 4,774E-03 0,0347485 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 2,000 4,774E-03 0,03463888 ! regulation of response to external stimulus GO:0032101 139 96 3,000 4,848E-03 0,03506071 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 4,933E-03 0,03556731 ! lipid phosphorylation GO:0046834 23 15 1,000 4,933E-03 0,03545616 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 4,933E-03 0,03534571 ! positive regulation of proteolysis GO:0045862 19 15 1,000 4,933E-03 0,03523594 ! cerebral cortex development GO:0021987 29 15 1,000 4,933E-03 0,03512685 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 4,933E-03 0,03501843 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 4,933E-03 0,03491068 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 4,933E-03 0,03480359 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 4,933E-03 0,03469716 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 4,933E-03 0,03459138 ! regulation of angiogenesis GO:0045765 94 49 2,000 5,059E-03 0,03537013 ! RNA elongation GO:0006354 62 49 2,000 5,059E-03 0,03526295 ! regulation of intracellular transport GO:0032386 78 49 2,000 5,059E-03 0,03515642 ! regulation of actin filament length GO:0030832 72 50 2,000 5,355E-03 0,03709698 ! negative regulation of cytoskeleton organization GO:0051494 84 50 2,000 5,355E-03 0,03698558 ! protein import GO:0017038 156 99 3,000 5,405E-03 0,03721829 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 5,405E-03 0,03710719 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 3,000 5,6E-03 0,03833059 ! protein localization in organelle GO:0033365 161 100 3,000 5,6E-03 0,03821685 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 5,612E-03 0,03818615 ! protein amino acid acetylation GO:0006473 28 16 1,000 5,612E-03 0,03807351 ! glial cell development GO:0021782 24 16 1,000 5,612E-03 0,03796153 ! fructose metabolic process GO:0006000 20 16 1,000 5,612E-03 0,0378502 ! neural crest cell migration GO:0001755 24 16 1,000 5,612E-03 0,03773953 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 5,612E-03 0,0376295 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 5,612E-03 0,03752011 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 5,612E-03 0,03741136 ! negative regulation of translation GO:0017148 22 16 1,000 5,612E-03 0,03730323 ! positive regulation of organelle organization GO:0010638 82 51 2,000 5,66E-03 0,03751879 ! transition metal ion transport GO:0000041 74 52 2,000 5,976E-03 0,03949842 ! regulation of cellular component size GO:0032535 74 52 2,000 5,976E-03 0,03938524 ! regulation of bone remodeling GO:0046850 90 53 2,000 6,302E-03 0,04141626 ! zinc ion transport GO:0006829 20 17 1,000 6,331E-03 0,04148233 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 6,331E-03 0,04136449 ! forelimb morphogenesis GO:0035136 19 17 1,000 6,331E-03 0,04124731 ! cellular macromolecular complex disassembly GO:0034623 29 17 1,000 6,331E-03 0,04113079 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 6,331E-03 0,04101493 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 6,331E-03 0,04089972 ! DNA catabolic process GO:0006308 67 54 2,000 6,639E-03 0,04277295 ! regulation of tissue remodeling GO:0034103 91 54 2,000 6,639E-03 0,04265347 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 7,089E-03 0,04541711 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 7,089E-03 0,04529096 ! visual learning GO:0008542 35 18 1,000 7,089E-03 0,0451655 ! somitogenesis GO:0001756 24 18 1,000 7,089E-03 0,04504073 ! purine nucleotide catabolic process GO:0006195 26 18 1,000 7,089E-03 0,04491665 ! estrogen receptor signaling pathway GO:0030520 30 18 1,000 7,089E-03 0,04479325 ! negative regulation of T cell activation GO:0050868 25 18 1,000 7,089E-03 0,04467053 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 7,712E-03 0,04846609 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 7,886E-03 0,0494248 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 7,886E-03 0,04929049 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 7,886E-03 0,04915691 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 32 19 1,000 7,886E-03 0,04902405 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 7,886E-03 0,04889191 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 7,886E-03 0,04876048 ! lung development GO:0030324 94 59 2,000 8,482E-03 0,05229931 ! iron ion transport GO:0006826 37 20 1,000 8,722E-03 0,05364018 ! hindlimb morphogenesis GO:0035137 32 20 1,000 8,722E-03 0,05349714 ! spinal cord development GO:0021510 31 20 1,000 8,722E-03 0,05335486 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 8,722E-03 0,05321334 ! pallium development GO:0021543 38 20 1,000 8,722E-03 0,05307256 ! positive regulation of locomotion GO:0040017 35 20 1,000 8,722E-03 0,05293253 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 1,000 8,722E-03 0,05279323 ! positive regulation of B cell activation GO:0050871 31 20 1,000 8,722E-03 0,05265467 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 8,722E-03 0,05251683 ! homeostasis of number of cells GO:0048872 84 61 2,000 9,294E-03 0,05581407 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 9,596E-03 0,05747657 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 9,596E-03 0,05732728 ! protein amino acid acylation GO:0043543 37 21 1,000 9,596E-03 0,05717876 ! regulation of chemotaxis GO:0050920 36 21 1,000 9,596E-03 0,05703102 ! vesicle docking GO:0048278 27 21 1,000 9,596E-03 0,05688403 ! dendrite development GO:0016358 35 21 1,000 9,596E-03 0,0567378 ! visual behavior GO:0007632 39 21 1,000 9,596E-03 0,05659232 ! purine ribonucleoside metabolic process GO:0046128 28 21 1,000 9,596E-03 0,05644758 GO:0042278|purine nucleoside metabolic process, ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 9,596E-03 0,05630358 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 9,596E-03 0,05616031 ! respiratory tube development GO:0030323 99 62 2,000 9,717E-03 0,05672399 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,01015093 0,05910671 GO:0090046|regulation of transcription regulator activity, ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01050709 0,06102605 ! molting cycle process GO:0022404 40 22 1,000 0,01050709 0,06087233 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 38 22 1,000 0,01050709 0,06071938 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01050709 0,0605672 ! barbed-end actin filament capping GO:0051016 33 22 1,000 0,01050709 0,06041579 GO:0051693|actin filament capping, ! regulation of behavior GO:0050795 38 22 1,000 0,01050709 0,06026512 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01050709 0,06011521 ! regulation of actin cytoskeleton organization GO:0032956 97 64 2,000 0,01059592 0,06047297 ! respiratory system development GO:0060541 100 64 2,000 0,01059592 0,06032328 ! regulation of caspase activity GO:0043281 97 65 2,000 0,01105206 0,06276478 ! defense response to bacterium GO:0042742 73 65 2,000 0,01105206 0,06261019 ! myelination GO:0042552 35 23 1,000 0,01145481 0,06473234 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01145481 0,06457369 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,01145481 0,0644158 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01145481 0,06425869 ! osteoblast differentiation GO:0001649 40 23 1,000 0,01145481 0,06410234 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01145481 0,06394676 ! group transfer coenzyme metabolic process GO:0006752 28 23 1,000 0,01145481 0,06379192 ! liver development GO:0001889 40 23 1,000 0,01145481 0,06363783 ! regulation of actin filament-based process GO:0032970 99 66 2,000 0,01151942 0,06384254 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,01199803 0,06633525 ! neural crest cell development GO:0014032 39 24 1,000 0,01243868 0,06860664 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 56 24 1,000 0,01243868 0,06844251 GO:0050768|negative regulation of neurogenesis, ! learning or memory GO:0007611 123 68 2,000 0,01248794 0,06854954 ! negative regulation of actin filament depolymerization GO:0030835 36 25 1,000 0,01345816 0,07369943 ! negative regulation of actin filament polymerization GO:0030837 36 25 1,000 0,01345816 0,07352437 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,01345816 0,07335014 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,01345816 0,07317674 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01345816 0,07300415 ! regulation of catabolic process GO:0009894 106 70 2,000 0,01350181 0,07306863 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,01402585 0,07572641 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01451269 0,07817138 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01451269 0,07798874 ! negative regulation of protein polymerization GO:0032272 38 26 1,000 0,01451269 0,07780695 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,01456132 0,07788615 ! tube morphogenesis GO:0035239 118 73 2,000 0,01510827 0,08062419 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 0,01560173 0,08306479 ! membrane docking GO:0022406 39 27 1,000 0,01560173 0,08287295 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01560173 0,082682 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01560173 0,08249193 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01560173 0,08230273 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,01560173 0,08211439 ! gene silencing GO:0016458 41 27 1,000 0,01560173 0,08192692 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 0,01566672 0,08208076 ! negative regulation of protein complex assembly GO:0031333 42 28 1,000 0,01672476 0,0874249 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01672476 0,08722666 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01672476 0,08702931 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01672476 0,08683286 GO:0008366|axon ensheathment, ! regulation of cell morphogenesis GO:0022604 140 76 2,000 0,0168182 0,08712133 ! regulation of protein transport GO:0051223 114 76 2,000 0,0168182 0,08692555 GO:0070201|regulation of establishment of protein localization, ! protein targeting to membrane GO:0006612 53 29 1,000 0,01788125 0,0922127 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01788125 0,09200641 ! telencephalon development GO:0021537 52 29 1,000 0,01788125 0,09180104 ! eye morphogenesis GO:0048592 51 29 1,000 0,01788125 0,09159658 ! collagen metabolic process GO:0032963 40 30 1,000 0,01907066 0,09747225 ! spindle organization GO:0007051 37 30 1,000 0,01907066 0,09725613 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,01907066 0,09704096 ! response to heat GO:0009408 41 30 1,000 0,01907066 0,09682674 ! chromatin assembly GO:0031497 102 80 2,000 0,01926008 0,09757307 GO:0006334|nucleosome assembly, ! regulation of GTPase activity GO:0043087 129 80 2,000 0,01926008 0,09735863 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02029248 0,10235244 ! glial cell differentiation GO:0010001 55 31 1,000 0,02029248 0,10212847 ! segmentation GO:0035282 41 31 1,000 0,02029248 0,10190549 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,02029248 0,10168347 ! metanephros development GO:0001656 58 31 1,000 0,02029248 0,10146242 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02029248 0,10124233 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02029248 0,10102319 ! leukocyte chemotaxis GO:0030595 43 31 1,000 0,02029248 0,10080499 GO:0060326|cell chemotaxis, ! ossification GO:0001503 134 82 2,000 0,02055069 0,10186765 GO:0060348|bone development, ! regulation of muscle development GO:0048634 48 32 1,000 0,02154621 0,10657265 ! peripheral nervous system development GO:0007422 53 32 1,000 0,02154621 0,10634395 ! regulation of protein stability GO:0031647 48 32 1,000 0,02154621 0,10611624 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02154621 0,10588949 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,02188785 0,10733914 ! protein-DNA complex assembly GO:0065004 107 84 2,000 0,02188785 0,10711076 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,0225739 0,11023346 ! regulation of protein localization GO:0032880 132 85 2,000 0,0225739 0,10999992 ! ear morphogenesis GO:0042471 42 33 1,000 0,02283133 0,11101916 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,02283133 0,11078494 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,02283133 0,11055171 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,02283133 0,11031946 ! nucleotide catabolic process GO:0009166 46 33 1,000 0,02283133 0,11008818 ! regulation of proteolysis GO:0030162 50 33 1,000 0,02283133 0,10985787 ! cytokinesis GO:0000910 52 33 1,000 0,02283133 0,10962852 ! nucleosome organization GO:0034728 114 87 2,000 0,02398092 0,11490857 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 2,000 0,02398092 0,11466967 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,02398092 0,11443177 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02414735 0,11498736 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02414735 0,11474978 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02414735 0,11451319 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,02414735 0,11427756 ! neuron migration GO:0001764 46 34 1,000 0,02414735 0,11404291 ! aerobic respiration GO:0009060 47 34 1,000 0,02414735 0,11380921 ! embryonic organ development GO:0048568 45 34 1,000 0,02414735 0,11357647 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 2,000 0,02470189 0,11594765 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,02470189 0,1157115 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 2,000 0,0254345 0,11890111 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,02549376 0,1189364 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02549376 0,11869564 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,02549376 0,11845585 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,02687008 0,12459917 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of binding GO:0051100 58 36 1,000 0,02687008 0,12434847 ! learning GO:0007612 67 37 1,000 0,02827583 0,13059117 ! gliogenesis GO:0042063 71 38 1,000 0,02971052 0,13694227 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,02971052 0,13666838 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,02971052 0,13639559 ! in utero embryonic development GO:0001701 147 96 2,000 0,03088771 0,14151741 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,03117368 0,14254366 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,03117368 0,14226083 ! developmental growth GO:0048589 62 39 1,000 0,03117368 0,14197913 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,03266484 0,14847655 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03266484 0,14818369 ! T cell differentiation GO:0030217 65 40 1,000 0,03266484 0,14789199 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,03266484 0,14760144 ! calcium ion transport GO:0006816 167 99 2,000 0,03339808 0,15061878 ! glucose transport GO:0015758 52 41 1,000 0,03418354 0,15385937 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,03418354 0,15355887 ! divalent metal ion transport GO:0070838 171 100 2,000 0,03425782 0,15359258 ! Ras protein signal transduction GO:0007265 162 100 2,000 0,03425782 0,15329376 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03496944 0,15617421 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03496944 0,15587154 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03496944 0,15557005 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03496944 0,15526972 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03496944 0,15497055 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03496944 0,15467253 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03496944 0,15437566 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03496944 0,15407992 ! sleep GO:0030431 11 5 0,000 0,03496944 0,15378531 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03496944 0,15349183 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03496944 0,15319946 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03496944 0,15290821 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03496944 0,15261806 ! tongue development GO:0043586 6 5 0,000 0,03496944 0,15232901 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03496944 0,15204105 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03496944 0,15175418 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03496944 0,15146839 ! cobalt ion transport GO:0006824 9 5 0,000 0,03496944 0,15118368 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03496944 0,15090003 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03496944 0,15061745 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03496944 0,15033592 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03496944 0,15005544 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03496944 0,14977601 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03496944 0,14949761 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03496944 0,14922025 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03496944 0,14894392 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03496944 0,14866861 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03496944 0,14839431 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03496944 0,14812102 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03496944 0,14784874 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,03496944 0,14757746 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03496944 0,14730717 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03496944 0,14703787 ! malate metabolic process GO:0006108 7 5 0,000 0,03496944 0,14676956 ! behavioral response to pain GO:0048266 7 5 0,000 0,03496944 0,14650222 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03496944 0,14623585 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03496944 0,14597045 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03496944 0,14570601 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03496944 0,14544252 ! mating behavior GO:0007617 6 5 0,000 0,03496944 0,14517999 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03496944 0,14491841 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03496944 0,14465776 ! rhythmic behavior GO:0007622 12 5 0,000 0,03496944 0,14439805 ! copulation GO:0007620 7 5 0,000 0,03496944 0,14413928 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03496944 0,14388142 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03496944 0,14362449 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03496944 0,14336848 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03496944 0,14311337 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03496944 0,14285918 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03496944 0,14260588 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03496944 0,14235348 ! response to protozoan GO:0001562 9 5 0,000 0,03496944 0,14210197 ! lymph vessel development GO:0001945 7 5 0,000 0,03496944 0,14185135 ! endochondral ossification GO:0001958 12 5 0,000 0,03496944 0,14160161 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03496944 0,14135275 ! parathyroid gland development GO:0060017 8 5 0,000 0,03496944 0,14110477 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03496944 0,14085765 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03496944 0,14061139 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03496944 0,140366 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03496944 0,14012146 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03496944 0,13987777 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03496944 0,13963492 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03496944 0,13939292 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03496944 0,13915176 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03496944 0,13891143 ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03496944 0,13867192 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03496944 0,13843325 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03496944 0,13819539 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03496944 0,13795835 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03496944 0,13772212 ! ovulation GO:0030728 6 5 0,000 0,03496944 0,13748669 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03496944 0,13725208 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,03496944 0,13701826 ! response to pH GO:0009268 9 5 0,000 0,03496944 0,13678523 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03496944 0,136553 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03496944 0,13632155 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03496944 0,13609089 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03496944 0,13586101 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03496944 0,1356319 ! polyol catabolic process GO:0046174 7 5 0,000 0,03496944 0,13540356 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03496944 0,13517599 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03496944 0,13494919 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03496944 0,13472314 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03496944 0,13449785 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03496944 0,13427332 ! urea metabolic process GO:0019627 6 5 0,000 0,03496944 0,13404953 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03496944 0,13382648 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03496944 0,13360418 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03496944 0,13338261 ! neutrophil activation GO:0042119 5 5 0,000 0,03496944 0,13316178 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03496944 0,13294168 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03496944 0,1327223 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03496944 0,13250365 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03496944 0,13228572 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03496944 0,1320685 ! forebrain neuron development GO:0021884 7 5 0,000 0,03496944 0,13185199 ! melanosome organization GO:0032438 7 5 0,000 0,03496944 0,1316362 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03496944 0,13142111 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03496944 0,13120672 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03496944 0,13099302 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03496944 0,13078003 ! nucleoside transport GO:0015858 6 5 0,000 0,03496944 0,13056772 ! nucleoside salvage GO:0043174 7 5 0,000 0,03496944 0,1303561 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03496944 0,13014517 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03496944 0,12993492 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03496944 0,12972535 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03496944 0,12951645 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03496944 0,12930823 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03496944 0,12910067 ! depyrimidination GO:0045008 8 5 0,000 0,03496944 0,12889378 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03496944 0,12868755 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03496944 0,12848197 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03496944 0,12827706 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03496944 0,1280728 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03496944 0,12786918 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03496944 0,12766622 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03496944 0,12746389 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03496944 0,12726221 ! monocyte differentiation GO:0030224 8 5 0,000 0,03496944 0,12706116 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03496944 0,12686075 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 5 5 0,000 0,03496944 0,12666097 ! response to UV-C GO:0010225 6 5 0,000 0,03496944 0,12646182 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03496944 0,12626329 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03496944 0,12606539 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03496944 0,1258681 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03496944 0,12567143 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03496944 0,12547538 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03496944 0,12527993 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03496944 0,1250851 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03496944 0,12489086 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03496944 0,12469723 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03496944 0,1245042 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03496944 0,12431177 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03496944 0,12411993 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03496944 0,12392868 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03496944 0,12373803 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03496944 0,12354795 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03496944 0,12335846 ! neural tube patterning GO:0021532 6 5 0,000 0,03496944 0,12316955 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03496944 0,12298122 ! histone demethylation GO:0016577 9 5 0,000 0,03496944 0,12279346 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03496944 0,12260627 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03496944 0,12241966 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,03496944 0,12223361 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03496944 0,12204813 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03496944 0,12186321 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03496944 0,12167884 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03496944 0,12149504 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03496944 0,12131179 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03496944 0,12112909 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03496944 0,12094694 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03496944 0,12076534 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03496944 0,12058428 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03496944 0,12040377 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03496944 0,12022379 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03496944 0,12004435 ! apical protein localization GO:0045176 6 5 0,000 0,03496944 0,11986545 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03496944 0,11968708 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03496944 0,11950924 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03496944 0,11933192 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03496944 0,11915514 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03496944 0,11897887 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03496944 0,11880313 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03496944 0,1186279 ! glial cell migration GO:0008347 10 5 0,000 0,03496944 0,11845319 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03496944 0,11827899 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03496944 0,11810531 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03496944 0,11793214 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03496944 0,11775947 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03496944 0,1175873 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03496944 0,11741564 ! neural plate development GO:0001840 6 5 0,000 0,03496944 0,11724448 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03496944 0,11707382 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03496944 0,11690366 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03496944 0,11673399 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03496944 0,11656481 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03496944 0,11639612 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03496944 0,11622791 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03496944 0,1160602 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03496944 0,11589296 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03496944 0,11572621 ! spindle assembly GO:0051225 5 5 0,000 0,03496944 0,11555994 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03496944 0,11539414 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03496944 0,11522882 ! organ regeneration GO:0031100 7 5 0,000 0,03496944 0,11506397 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03496944 0,11489959 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03496944 0,11473569 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03496944 0,11457225 GO:0055081|anion homeostasis, ! hexose transport GO:0008645 54 42 1,000 0,03572932 0,11689535 GO:0015749|monosaccharide transport, ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,03730172 0,12186641 ! leukocyte migration GO:0050900 60 43 1,000 0,03730172 0,12169355 ! glycolysis GO:0006096 53 44 1,000 0,0389003 0,12672902 ! regulation of action potential GO:0001508 71 44 1,000 0,0389003 0,12654977 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,0389003 0,12637103 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,0389003 0,12619279 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,04052461 0,1312769 ! tRNA transcription GO:0009304 11 6 0,000 0,04181637 0,13527096 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04181637 0,13508098 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04181637 0,13489152 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04181637 0,1347026 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04181637 0,1345142 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04181637 0,13432633 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04181637 0,13413899 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04181637 0,13395216 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04181637 0,13376586 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04181637 0,13358008 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04181637 0,13339481 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04181637 0,13321005 ! prostate gland development GO:0030850 9 6 0,000 0,04181637 0,1330258 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04181637 0,13284206 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04181637 0,13265883 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04181637 0,13247611 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04181637 0,13229389 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04181637 0,13211216 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04181637 0,13193094 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04181637 0,13175021 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04181637 0,13156998 ! neuron adhesion GO:0007158 9 6 0,000 0,04181637 0,13139024 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04181637 0,13121099 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04181637 0,13103223 ! signal peptide processing GO:0006465 8 6 0,000 0,04181637 0,13085395 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04181637 0,13067616 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04181637 0,13049885 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04181637 0,13032203 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04181637 0,13014568 ! opsonization GO:0008228 8 6 0,000 0,04181637 0,1299698 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04181637 0,12979441 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04181637 0,12961948 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04181637 0,12944503 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04181637 0,12927104 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04181637 0,12909752 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04181637 0,12892447 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04181637 0,12875188 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04181637 0,12857975 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04181637 0,12840808 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04181637 0,12823687 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04181637 0,12806612 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04181637 0,12789582 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04181637 0,12772597 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04181637 0,12755657 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04181637 0,12738762 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04181637 0,12721912 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04181637 0,12705106 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04181637 0,12688345 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04181637 0,12671628 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04181637 0,12654955 ! thymic T cell selection GO:0045061 12 6 0,000 0,04181637 0,12638325 ! protein lipoylation GO:0009249 10 6 0,000 0,04181637 0,12621739 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04181637 0,12605197 ! pigment granule organization GO:0048753 11 6 0,000 0,04181637 0,12588698 ! drug transport GO:0015893 6 6 0,000 0,04181637 0,12572242 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04181637 0,1255583 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04181637 0,1253946 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04181637 0,12523132 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04181637 0,12506847 ! histidine metabolic process GO:0006547 6 6 0,000 0,04181637 0,12490604 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04181637 0,12474404 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04181637 0,12458245 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04181637 0,12442129 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04181637 0,12426054 ! adenohypophysis development GO:0021984 10 6 0,000 0,04181637 0,1241002 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04181637 0,12394028 ! hyperosmotic response GO:0006972 8 6 0,000 0,04181637 0,12378077 ! microtubule nucleation GO:0007020 10 6 0,000 0,04181637 0,12362166 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04181637 0,12346297 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04181637 0,12330469 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04181637 0,1231468 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04181637 0,12298933 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04181637 0,12283225 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,04181637 0,12267558 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04181637 0,12251931 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04181637 0,12236343 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04181637 0,12220795 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04181637 0,12205286 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04181637 0,12189817 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04181637 0,12174387 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04181637 0,12158996 ! neuron apoptosis GO:0051402 8 6 0,000 0,04181637 0,12143643 ! organic alcohol transport GO:0015850 9 6 0,000 0,04181637 0,1212833 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04181637 0,12113055 ! male sex determination GO:0030238 9 6 0,000 0,04181637 0,12097818 ! carnitine transport GO:0015879 8 6 0,000 0,04181637 0,1208262 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04181637 0,1206746 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04181637 0,12052338 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04181637 0,12037253 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04181637 0,12022207 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04181637 0,12007198 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04181637 0,11992226 ! parturition GO:0007567 12 6 0,000 0,04181637 0,11977292 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04181637 0,11962395 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04181637 0,11947535 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04181637 0,11932711 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04181637 0,11917925 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,04181637 0,11903175 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04181637 0,11888462 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04181637 0,11873785 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04181637 0,11859144 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04181637 0,11844539 ! macrophage differentiation GO:0030225 10 6 0,000 0,04181637 0,1182997 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04181637 0,11815437 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04181637 0,11800939 ! interaction with symbiont GO:0051702 8 6 0,000 0,04181637 0,11786477 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04181637 0,11772051 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04181637 0,11757659 ! eating behavior GO:0042755 6 6 0,000 0,04181637 0,11743303 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04181637 0,11728982 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04181637 0,11714696 ! response to copper ion GO:0046688 9 6 0,000 0,04181637 0,11700445 ! DNA topological change GO:0006265 8 6 0,000 0,04181637 0,11686228 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04181637 0,11672045 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04181637 0,11657898 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04181637 0,11643784 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04181637 0,11629704 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04181637 0,11615659 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04181637 0,11601647 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04181637 0,11587669 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04181637 0,11573725 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04181637 0,11559814 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04181637 0,11545937 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04181637 0,11532093 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04181637 0,11518282 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04181637 0,11504504 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04181637 0,11490759 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04181637 0,11477047 ! histone ubiquitination GO:0016574 7 6 0,000 0,04181637 0,11463368 ! regulation of meiosis GO:0040020 10 6 0,000 0,04181637 0,11449721 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04181637 0,11436106 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04181637 0,11422524 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04181637 0,11408974 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04181637 0,11395457 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04181637 0,11381971 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04181637 0,11368517 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04181637 0,11355095 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04181637 0,11341705 ! receptor internalization GO:0031623 9 6 0,000 0,04181637 0,11328346 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04181637 0,11315018 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04181637 0,11301722 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04181637 0,11288457 ! protein deubiquitination GO:0016579 8 6 0,000 0,04181637 0,11275223 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04181637 0,1126202 ! axonal fasciculation GO:0007413 9 6 0,000 0,04181637 0,11248848 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04181637 0,11235707 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04181637 0,11222597 ! midbrain development GO:0030901 6 6 0,000 0,04181637 0,11209517 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04181637 0,11196467 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04181637 0,11183448 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04181637 0,11170459 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04181637 0,11157501 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04181637 0,11144572 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04181637 0,11131673 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04181637 0,11118804 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04181637 0,11105965 ! adult feeding behavior GO:0008343 6 6 0,000 0,04181637 0,11093155 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04181637 0,11080375 ! blastocyst growth GO:0001832 15 6 0,000 0,04181637 0,11067624 ! pigment granule transport GO:0051904 12 6 0,000 0,04181637 0,11054903 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04181637 0,11042211 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04181637 0,11029548 ! catecholamine transport GO:0051937 7 6 0,000 0,04181637 0,11016913 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04181637 0,11004308 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04181637 0,10991732 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04181637 0,10979184 ! protein prenylation GO:0018342 10 6 0,000 0,04181637 0,10966665 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04181637 0,10954175 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04181637 0,10941713 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 1,000 0,04217421 0,11022806 ! histone modification GO:0016570 68 46 1,000 0,04217421 0,11010294 ! endocrine system development GO:0035270 83 47 1,000 0,04384868 0,11434462 ! covalent chromatin modification GO:0016569 75 47 1,000 0,04384868 0,11421513 ! positive regulation of cyclase activity GO:0031281 87 47 1,000 0,04384868 0,11408592 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,04384868 0,11395701 ! response to temperature stimulus GO:0009266 62 48 1,000 0,04554757 0,11823861 ! heart morphogenesis GO:0003007 65 48 1,000 0,04554757 0,11810531 ! positive regulation of lyase activity GO:0051349 88 48 1,000 0,04554757 0,11797231 ! regulation of endocytosis GO:0030100 63 48 1,000 0,04554757 0,11783961 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,04554757 0,1177072 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,04554757 0,11757509 ! germ cell development GO:0007281 68 49 1,000 0,04727047 0,12188573 ! heterocycle catabolic process GO:0046700 72 49 1,000 0,04727047 0,12174924 ! cartilage development GO:0051216 70 49 1,000 0,04727047 0,12161306 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04861511 0,12493269 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04861511 0,12479325 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04861511 0,12465413 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04861511 0,12451532 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04861511 0,12437681 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04861511 0,12423862 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04861511 0,12410073 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04861511 0,12396314 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04861511 0,12382586 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04861511 0,12368889 ! reproductive behavior GO:0019098 12 7 0,000 0,04861511 0,12355222 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04861511 0,12341584 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04861511 0,12327977 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,04861511 0,123144 ! oligopeptide transport GO:0006857 11 7 0,000 0,04861511 0,12300853 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04861511 0,12287336 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04861511 0,12273848 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,04861511 0,1226039 ! pericardium development GO:0060039 8 7 0,000 0,04861511 0,12246961 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04861511 0,12233562 ! fibril organization GO:0043206 13 7 0,000 0,04861511 0,12220192 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04861511 0,12206851 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04861511 0,12193539 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04861511 0,12180257 ! lipoprotein transport GO:0042953 9 7 0,000 0,04861511 0,12167003 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04861511 0,12153778 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04861511 0,12140581 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04861511 0,12127414 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04861511 0,12114275 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04861511 0,12101164 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04861511 0,12088082 ! chemosensory behavior GO:0007635 9 7 0,000 0,04861511 0,12075028 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04861511 0,12062002 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04861511 0,12049004 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04861511 0,12036034 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04861511 0,12023092 ! reflex GO:0060004 12 7 0,000 0,04861511 0,12010178 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04861511 0,11997291 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04861511 0,11984432 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04861511 0,11971601 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04861511 0,11958797 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04861511 0,11946021 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04861511 0,11933272 ! spinal cord patterning GO:0021511 7 7 0,000 0,04861511 0,1192055 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04861511 0,11907855 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04861511 0,11895187 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04861511 0,11882546 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04861511 0,11869932 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04861511 0,11857344 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04861511 0,11844783 ! endosome organization GO:0007032 10 7 0,000 0,04861511 0,11832249 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04861511 0,11819742 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04861511 0,1180726 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04861511 0,11794805 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,04861511 0,11782377 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04861511 0,11769974 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04861511 0,11757598 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04861511 0,11745247 ! galactose metabolic process GO:0006012 10 7 0,000 0,04861511 0,11732923 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04861511 0,11720624 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04861511 0,11708351 ! organ growth GO:0035265 11 7 0,000 0,04861511 0,11696104 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04861511 0,11683882 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04861511 0,11671686 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04861511 0,11659516 ! retinol metabolic process GO:0042572 9 7 0,000 0,04861511 0,1164737 ! behavioral fear response GO:0001662 13 7 0,000 0,04861511 0,1163525 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04861511 0,11623155 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04861511 0,11611086 ! rRNA modification GO:0000154 12 7 0,000 0,04861511 0,11599041 ! protein heterooligomerization GO:0051291 10 7 0,000 0,04861511 0,11587021 ! response to UV-B GO:0010224 11 7 0,000 0,04861511 0,11575026 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04861511 0,11563056 ! intermediate filament organization GO:0045109 11 7 0,000 0,04861511 0,11551111 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04861511 0,1153919 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04861511 0,11527294 ! fibrinolysis GO:0042730 9 7 0,000 0,04861511 0,11515423 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04861511 0,11503576 ! B cell lineage commitment GO:0002326 17 7 0,000 0,04861511 0,11491753 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04861511 0,11479954 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04861511 0,1146818 ! response to tropane GO:0014073 13 7 0,000 0,04861511 0,1145643 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04861511 0,11444704 ! melanosome localization GO:0032400 10 7 0,000 0,04861511 0,11433002 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04861511 0,11421323 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04861511 0,11409669 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04861511 0,11398038 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04861511 0,11386431 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04861511 0,11374848 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04861511 0,11363288 ! mast cell activation GO:0045576 9 7 0,000 0,04861511 0,11351752 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04861511 0,11340239 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04861511 0,11328749 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04861511 0,11317283 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04861511 0,1130584 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04861511 0,1129442 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04861511 0,11283023 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04861511 0,11271649 ! T cell lineage commitment GO:0002360 12 7 0,000 0,04861511 0,11260298 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04861511 0,11248969 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04861511 0,11237664 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04861511 0,11226381 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04861511 0,11215121 ! response to tumor cell GO:0002347 12 7 0,000 0,04861511 0,11203883 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04861511 0,11192668 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04861511 0,11181476 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04861511 0,11170305 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04861511 0,11159157 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,04861511 0,11148031 ! diuresis GO:0030146 12 7 0,000 0,04861511 0,11136928 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04861511 0,11125846 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04861511 0,11114787 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04861511 0,11103749 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04861511 0,11092734 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04861511 0,1108174 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04861511 0,11070768 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04861511 0,11059818 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04861511 0,11048889 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04861511 0,11037982 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,04861511 0,11027096 ! lymph node development GO:0048535 9 7 0,000 0,04861511 0,11016232 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04861511 0,11005389 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04861511 0,10994568 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04861511 0,10983768 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04861511 0,10972989 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04861511 0,10962231 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04861511 0,10951494 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04861511 0,10940778 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04861511 0,10930084 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04861511 0,1091941 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04861511 0,10908757 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04861511 0,10898124 ! muscle adaptation GO:0043500 12 7 0,000 0,04861511 0,10887513 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04861511 0,10876922 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04861511 0,10866351 ! retina homeostasis GO:0001895 9 7 0,000 0,04861511 0,10855801 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04861511 0,10845272 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04861511 0,10834763 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04861511 0,10824274 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04861511 0,10813806 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04861511 0,10803358 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04861511 0,1079293 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04861511 0,10782522 ! ear development GO:0043583 72 50 1,000 0,04901695 0,10861174 ! membrane fusion GO:0006944 80 50 1,000 0,04901695 0,10850721 ! lipid modification GO:0030258 73 50 1,000 0,04901695 0,10840287 ! positive regulation of growth GO:0045927 67 50 1,000 0,04901695 0,10829874 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,04901695 0,1081948 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,0507866 0,11199347 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,0507866 0,1118862 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,0507866 0,11177913 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,05257902 0,11561352 ! aging GO:0007568 79 52 1,000 0,05257902 0,11550309 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,05439378 0,11937567 ! kidney development GO:0001822 90 53 1,000 0,05439378 0,11926187 ! cell projection assembly GO:0030031 76 53 1,000 0,05439378 0,11914829 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,055366 0,1211625 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,055366 0,12104733 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,055366 0,12093238 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,055366 0,12081764 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,055366 0,12070312 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,055366 0,12058882 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,055366 0,12047473 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,055366 0,12036086 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,055366 0,12024721 ! phosphate transport GO:0006817 10 8 0,000 0,055366 0,12013377 ! N-glycan processing GO:0006491 12 8 0,000 0,055366 0,12002054 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,055366 0,11990753 ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,055366 0,11979472 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,055366 0,11968214 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,055366 0,11956976 ! succinate metabolic process GO:0006105 14 8 0,000 0,055366 0,11945759 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,055366 0,11934563 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,055366 0,11923389 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,055366 0,11912235 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,055366 0,11901102 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,055366 0,1188999 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,055366 0,11878899 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,055366 0,11867828 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,055366 0,11856778 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,055366 0,11845748 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,055366 0,11834739 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,055366 0,1182375 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,055366 0,11812782 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,055366 0,11801834 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,055366 0,11790907 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,055366 0,11779999 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,055366 0,11769112 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,055366 0,11758245 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,055366 0,11747398 ! melanin metabolic process GO:0006582 12 8 0,000 0,055366 0,11736571 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,055366 0,11725764 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,055366 0,11714976 ! macrophage activation GO:0042116 12 8 0,000 0,055366 0,11704209 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,055366 0,11693461 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,055366 0,11682733 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,055366 0,11672025 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,055366 0,11661336 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,055366 0,11650667 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,055366 0,11640018 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,055366 0,11629387 ! ruffle organization GO:0031529 11 8 0,000 0,055366 0,11618777 ! osteoblast development GO:0002076 13 8 0,000 0,055366 0,11608185 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,055366 0,11597613 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,055366 0,1158706 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,055366 0,11576527 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,055366 0,11566012 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,055366 0,11555517 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,055366 0,1154504 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,055366 0,11534583 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,055366 0,11524144 ! oligodendrocyte development GO:0014003 8 8 0,000 0,055366 0,11513724 ! segment specification GO:0007379 10 8 0,000 0,055366 0,11503324 ! cellular extravasation GO:0045123 11 8 0,000 0,055366 0,11492942 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,055366 0,11482578 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,055366 0,11472234 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,055366 0,11461907 ! snRNA metabolic process GO:0016073 10 8 0,000 0,055366 0,114516 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,055366 0,11441311 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,055366 0,11431041 ! nucleosome disassembly GO:0006337 12 8 0,000 0,055366 0,11420789 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,055366 0,11410555 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,055366 0,11400339 ! icosanoid secretion GO:0032309 12 8 0,000 0,055366 0,11390142 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,055366 0,11379964 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,055366 0,11369803 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,055366 0,1135966 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,055366 0,11349536 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,055366 0,11339429 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,055366 0,11329341 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,055366 0,1131927 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,055366 0,11309218 ! sterol catabolic process GO:0016127 9 8 0,000 0,055366 0,11299183 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,055366 0,11289166 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,055366 0,11279167 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,055366 0,11269185 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,055366 0,11259221 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,055366 0,11249275 ! prophase GO:0051324 11 8 0,000 0,055366 0,11239346 ! S phase GO:0051320 8 8 0,000 0,055366 0,11229435 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,055366 0,11219541 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,055366 0,11209665 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,055366 0,11199806 ! hormone catabolic process GO:0042447 13 8 0,000 0,055366 0,11189964 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,055366 0,1118014 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,055366 0,11170333 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,055366 0,11160543 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,055366 0,1115077 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,055366 0,11141014 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,055366 0,11131276 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,055366 0,11121554 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,055366 0,11111849 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,055366 0,11102161 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,055366 0,11092491 ! lamellipodium assembly GO:0030032 9 8 0,000 0,055366 0,11082837 ! regulation of embryonic development GO:0045995 16 8 0,000 0,055366 0,11073199 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,055366 0,11063579 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,055366 0,11053975 ! glucose catabolic process GO:0006007 66 54 1,000 0,0562305 0,11216839 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,0562305 0,11207119 ! detection of external stimulus GO:0009581 66 54 1,000 0,0562305 0,11197416 ! cellular amino acid catabolic process GO:0009063 74 54 1,000 0,0562305 0,1118773 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,0562305 0,1117806 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,05996821 0,11910785 ! negative regulation of response to stimulus GO:0048585 80 56 1,000 0,05996821 0,11900508 ! carbohydrate transport GO:0008643 74 57 1,000 0,06186842 0,12267014 ! camera-type eye development GO:0043010 88 57 1,000 0,06186842 0,12256449 ! developmental maturation GO:0021700 75 57 1,000 0,06186842 0,12245901 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06206936 0,1227511 ! regulation of developmental growth GO:0048638 13 9 0,000 0,06206936 0,12264565 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06206936 0,12254037 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06206936 0,12243528 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06206936 0,12233036 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06206936 0,12222563 GO:0010469|regulation of receptor activity, ! elastic fiber assembly GO:0048251 13 9 0,000 0,06206936 0,12212107 ! social behavior GO:0035176 14 9 0,000 0,06206936 0,1220167 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06206936 0,1219125 ! regulation of histone modification GO:0031056 11 9 0,000 0,06206936 0,12180848 ! response to pain GO:0048265 16 9 0,000 0,06206936 0,12170463 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06206936 0,12160097 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06206936 0,12149748 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06206936 0,12139416 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06206936 0,12129102 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06206936 0,12118806 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06206936 0,12108527 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06206936 0,12098266 ! T cell selection GO:0045058 18 9 0,000 0,06206936 0,12088021 ! endoderm development GO:0007492 12 9 0,000 0,06206936 0,12077795 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06206936 0,12067585 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06206936 0,12057393 ! arginine catabolic process GO:0006527 10 9 0,000 0,06206936 0,12047218 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06206936 0,1203706 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06206936 0,12026919 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06206936 0,12016796 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06206936 0,12006689 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,06206936 0,11996599 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06206936 0,11986527 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06206936 0,11976471 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06206936 0,11966432 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06206936 0,1195641 ! mannose metabolic process GO:0006013 9 9 0,000 0,06206936 0,11946404 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06206936 0,11936416 ! receptor clustering GO:0043113 15 9 0,000 0,06206936 0,11926444 ! epithelial cell development GO:0002064 10 9 0,000 0,06206936 0,11916489 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06206936 0,1190655 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06206936 0,11896628 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06206936 0,11886722 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06206936 0,11876833 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06206936 0,1186696 ! motor axon guidance GO:0008045 14 9 0,000 0,06206936 0,11857104 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06206936 0,11847264 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06206936 0,11837441 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06206936 0,11827633 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06206936 0,11817842 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06206936 0,11808067 ! DNA ligation GO:0006266 14 9 0,000 0,06206936 0,11798309 ! response to amine stimulus GO:0014075 13 9 0,000 0,06206936 0,11788566 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06206936 0,11778839 ! erythrocyte development GO:0048821 11 9 0,000 0,06206936 0,11769129 ! renal water homeostasis GO:0003091 14 9 0,000 0,06206936 0,11759434 ! postreplication repair GO:0006301 11 9 0,000 0,06206936 0,11749756 ! mRNA cleavage GO:0006379 13 9 0,000 0,06206936 0,11740093 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06206936 0,11730446 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06206936 0,11720816 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06206936 0,117112 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06206936 0,11701601 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06206936 0,11692018 ! acid secretion GO:0046717 14 9 0,000 0,06206936 0,1168245 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06206936 0,11672897 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06206936 0,11663361 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06206936 0,11653839 ! purine base metabolic process GO:0006144 18 9 0,000 0,06206936 0,11644334 ! oocyte differentiation GO:0009994 12 9 0,000 0,06206936 0,11634844 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,06206936 0,11625369 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06206936 0,1161591 ! spleen development GO:0048536 15 9 0,000 0,06206936 0,11606466 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06206936 0,11597038 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06206936 0,11587624 ! detection of calcium ion GO:0005513 13 9 0,000 0,06206936 0,11578227 ! blastocyst formation GO:0001825 12 9 0,000 0,06206936 0,11568844 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06206936 0,11559476 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06206936 0,11550124 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06206936 0,11540787 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06206936 0,11531465 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06206936 0,11522158 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06206936 0,11512866 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06206936 0,11503589 ! prepulse inhibition GO:0060134 14 9 0,000 0,06206936 0,11494326 ! insulin secretion GO:0030073 17 9 0,000 0,06206936 0,11485079 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06206936 0,11475847 ! response to nicotine GO:0035094 16 9 0,000 0,06206936 0,11466629 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06206936 0,11457426 ! nucleus localization GO:0051647 15 9 0,000 0,06206936 0,11448238 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06206936 0,11439065 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,06572963 0,12103936 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,06768988 0,12454938 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,06768988 0,12444982 GO:0035113|embryonic appendage morphogenesis, ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,06768988 0,12435042 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06872554 0,12615223 ! neuron fate specification GO:0048665 11 10 0,000 0,06872554 0,12605163 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,06872554 0,12595119 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,06872554 0,12585091 ! thyroid gland development GO:0030878 19 10 0,000 0,06872554 0,12575079 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,06872554 0,12565083 ! synapsis GO:0007129 13 10 0,000 0,06872554 0,12555103 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06872554 0,12545138 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,06872554 0,1253519 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06872554 0,12525257 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,06872554 0,1251534 ! sulfate transport GO:0008272 12 10 0,000 0,06872554 0,12505439 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06872554 0,12495553 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,06872554 0,12485683 ! androgen metabolic process GO:0008209 13 10 0,000 0,06872554 0,12475828 ! phospholipid efflux GO:0033700 16 10 0,000 0,06872554 0,12465989 ! hippocampus development GO:0021766 19 10 0,000 0,06872554 0,12456166 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,06872554 0,12446358 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,06872554 0,12436565 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06872554 0,12426788 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,06872554 0,12417026 ! pathogenesis GO:0009405 13 10 0,000 0,06872554 0,1240728 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06872554 0,12397548 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06872554 0,12387833 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06872554 0,12378132 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,06872554 0,12368446 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06872554 0,12358776 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06872554 0,12349121 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06872554 0,1233948 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06872554 0,12329855 ! response to X-ray GO:0010165 16 10 0,000 0,06872554 0,12320245 ! B cell proliferation GO:0042100 14 10 0,000 0,06872554 0,1231065 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,06872554 0,1230107 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,06872554 0,12291504 ! forebrain cell migration GO:0021885 17 10 0,000 0,06872554 0,12281954 ! lipid digestion GO:0044241 15 10 0,000 0,06872554 0,12272418 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06872554 0,12262897 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,06872554 0,12253391 ! UV protection GO:0009650 14 10 0,000 0,06872554 0,122439 ! entry into host cell GO:0030260 20 10 0,000 0,06872554 0,12234423 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,06872554 0,12224961 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06872554 0,12215513 ! negative regulation of ossification GO:0030279 19 10 0,000 0,06872554 0,12206081 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,06872554 0,12196662 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06872554 0,12187259 ! regulation of organ growth GO:0046620 11 10 0,000 0,06872554 0,12177869 ! response to dsRNA GO:0043331 18 10 0,000 0,06872554 0,12168494 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06872554 0,12159134 ! embryonic axis specification GO:0000578 12 10 0,000 0,06872554 0,12149788 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,06872554 0,12140456 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,06872554 0,12131139 ! cranial nerve development GO:0021545 12 10 0,000 0,06872554 0,12121836 ! fucose catabolic process GO:0019317 16 10 0,000 0,06872554 0,12112547 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,06872554 0,12103273 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,06872554 0,12094012 ! protein sumoylation GO:0016925 12 10 0,000 0,06872554 0,12084766 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06872554 0,12075534 ! zymogen activation GO:0031638 14 10 0,000 0,06872554 0,12066316 ! salivary gland development GO:0007431 22 10 0,000 0,06872554 0,12057112 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06872554 0,12047923 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,06872554 0,12038747 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,06872554 0,12029585 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06872554 0,12020437 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,06872554 0,12011303 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06872554 0,12002182 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06872554 0,11993076 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06872554 0,11983984 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06872554 0,11974905 ! detection of bacterium GO:0016045 10 10 0,000 0,06872554 0,1196584 ! embryonic gut development GO:0048566 11 10 0,000 0,06872554 0,11956788 ! activation of innate immune response GO:0002218 10 10 0,000 0,06872554 0,11947751 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,06872554 0,11938727 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,06872554 0,11929716 ! developmental induction GO:0031128 13 10 0,000 0,06872554 0,1192072 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,06872554 0,11911736 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,06872554 0,11902767 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06872554 0,11893811 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,06872554 0,11884868 ! meiosis GO:0007126 96 61 1,000 0,06966939 0,12039039 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,06966939 0,1203 ! urogenital system development GO:0001655 101 61 1,000 0,06966939 0,12020976 ! extracellular matrix organization GO:0030198 103 61 1,000 0,06966939 0,12011964 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,06966939 0,12002967 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 1,000 0,0716678 0,1233802 ! meiotic cell cycle GO:0051321 97 62 1,000 0,0716678 0,12328792 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,07368475 0,12666288 ! regulation of lipase activity GO:0060191 109 63 1,000 0,07368475 0,12656828 ! rRNA transcription GO:0009303 17 11 0,000 0,07533486 0,1293061 ! respiratory burst GO:0045730 14 11 0,000 0,07533486 0,12920968 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07533486 0,1291134 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,07533486 0,12901726 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07533486 0,12892126 ! virus-host interaction GO:0019048 17 11 0,000 0,07533486 0,12882541 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,07533486 0,1287297 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,07533486 0,12863413 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07533486 0,12853871 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07533486 0,12844342 ! mating GO:0007618 14 11 0,000 0,07533486 0,12834828 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,07533486 0,12825328 ! T cell proliferation GO:0042098 20 11 0,000 0,07533486 0,12815842 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07533486 0,12806369 ! bone resorption GO:0045453 16 11 0,000 0,07533486 0,12796911 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07533486 0,12787467 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07533486 0,12778037 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,07533486 0,1276862 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,07533486 0,12759218 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07533486 0,12749829 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07533486 0,12740454 ! syncytium formation GO:0006949 15 11 0,000 0,07533486 0,12731093 ! plasma membrane organization GO:0007009 18 11 0,000 0,07533486 0,12721746 ! focal adhesion formation GO:0048041 24 11 0,000 0,07533486 0,12712412 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07533486 0,12703092 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07533486 0,12693786 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,07533486 0,12684493 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07533486 0,12675214 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07533486 0,12665949 ! adult heart development GO:0007512 11 11 0,000 0,07533486 0,12656697 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,07533486 0,12647458 ! temperature homeostasis GO:0001659 16 11 0,000 0,07533486 0,12638233 ! L-glutamate transport GO:0015813 16 11 0,000 0,07533486 0,12629022 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07533486 0,12619824 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07533486 0,12610639 ! stem cell development GO:0048864 29 11 0,000 0,07533486 0,12601468 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07533486 0,12592309 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07533486 0,12583165 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07533486 0,12574033 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,07533486 0,12564915 ! vasoconstriction GO:0042310 15 11 0,000 0,07533486 0,1255581 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,07533486 0,12546718 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07533486 0,1253764 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07533486 0,12528574 ! ribosome assembly GO:0042255 13 11 0,000 0,07533486 0,12519522 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,07533486 0,12510482 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,07533486 0,12501456 ! chromatin silencing GO:0006342 19 11 0,000 0,07533486 0,12492443 ! nucleosome positioning GO:0016584 13 11 0,000 0,07533486 0,12483442 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07533486 0,12474455 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07533486 0,1246548 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07533486 0,12456519 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07533486 0,1244757 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07533486 0,12438634 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07533486 0,12429712 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07533486 0,12420801 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07533486 0,12411904 ! male genitalia development GO:0030539 13 11 0,000 0,07533486 0,12403019 ! cholesterol efflux GO:0033344 19 11 0,000 0,07533486 0,12394147 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,07533486 0,12385288 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07533486 0,12376441 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07533486 0,12367607 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,07533486 0,12358786 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,07533486 0,12349977 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07533486 0,12341181 ! defense response to fungus GO:0050832 12 11 0,000 0,07533486 0,12332397 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07533486 0,12323626 ! lysogeny GO:0030069 18 11 0,000 0,07533486 0,12314867 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,07533486 0,12306121 ! acrosome reaction GO:0007340 13 11 0,000 0,07533486 0,12297387 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07533486 0,12288665 ! appendage morphogenesis GO:0035107 93 64 1,000 0,07571988 0,12342715 GO:0035108|limb morphogenesis, ! hexose catabolic process GO:0019320 82 64 1,000 0,07571988 0,12333974 ! adaptive immune response GO:0002250 94 64 1,000 0,07571988 0,12325245 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 1,000 0,07777282 0,12650459 GO:0060173|limb development, ! cell-substrate adhesion GO:0031589 121 66 1,000 0,07984324 0,12978053 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,07984324 0,12968888 ! lactation GO:0007595 20 12 0,000 0,08189765 0,13293196 ! reproductive cellular process GO:0048610 14 12 0,000 0,08189765 0,13283822 ! tRNA modification GO:0006400 14 12 0,000 0,08189765 0,1327446 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08189765 0,13265112 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08189765 0,13255777 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08189765 0,13246455 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08189765 0,13237146 ! non-recombinational repair GO:0000726 19 12 0,000 0,08189765 0,13227851 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08189765 0,13218568 ! peroxisomal transport GO:0043574 21 12 0,000 0,08189765 0,13209298 ! cartilage condensation GO:0001502 18 12 0,000 0,08189765 0,13200041 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08189765 0,13190798 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08189765 0,13181567 ! palate development GO:0060021 15 12 0,000 0,08189765 0,13172349 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08189765 0,13163144 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08189765 0,13153952 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,08189765 0,13144773 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08189765 0,13135606 ! arginine metabolic process GO:0006525 13 12 0,000 0,08189765 0,13126452 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08189765 0,13117311 ! methionine metabolic process GO:0006555 13 12 0,000 0,08189765 0,13108183 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08189765 0,13099068 ! Golgi organization GO:0007030 18 12 0,000 0,08189765 0,13089965 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08189765 0,13080874 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08189765 0,13071797 ! monoamine transport GO:0015844 13 12 0,000 0,08189765 0,13062732 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08189765 0,13053679 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08189765 0,13044639 ! L-amino acid transport GO:0015807 20 12 0,000 0,08189765 0,13035612 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08189765 0,13026597 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08189765 0,13017594 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08189765 0,13008604 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08189765 0,12999627 ! cerebellum development GO:0021549 13 12 0,000 0,08189765 0,12990662 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08189765 0,12981709 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08189765 0,12972768 ! histone methylation GO:0016571 15 12 0,000 0,08189765 0,1296384 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08189765 0,12954924 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08189765 0,1294602 ! response to gamma radiation GO:0010332 20 12 0,000 0,08189765 0,12937129 ! intestinal absorption GO:0050892 19 12 0,000 0,08189765 0,12928249 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08189765 0,12919382 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08189765 0,12910527 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08189765 0,12901684 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08189765 0,12892854 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08189765 0,12884035 ! microspike assembly GO:0030035 23 12 0,000 0,08189765 0,12875228 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08189765 0,12866434 ! response to cold GO:0009409 14 12 0,000 0,08189765 0,12857651 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,08403511 0,13184227 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,08829277 0,13842766 ! humoral immune response GO:0006959 86 70 1,000 0,08829277 0,13833336 ! eye development GO:0001654 111 70 1,000 0,08829277 0,1382392 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,08829277 0,13814515 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,08841423 0,13824115 ! cGMP metabolic process GO:0046068 16 13 0,000 0,08841423 0,13814724 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,08841423 0,13805345 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,08841423 0,13795979 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,08841423 0,13786626 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,08841423 0,13777285 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,08841423 0,13767957 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,08841423 0,13758642 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,08841423 0,13749339 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,08841423 0,13740049 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,08841423 0,13730772 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,08841423 0,13721507 ! response to hexose stimulus GO:0009746 19 13 0,000 0,08841423 0,13712254 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,08841423 0,13703014 ! glutamate metabolic process GO:0006536 18 13 0,000 0,08841423 0,13693787 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,08841423 0,13684571 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,08841423 0,13675369 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,08841423 0,13666178 ! NAD metabolic process GO:0019674 21 13 0,000 0,08841423 0,13657 ! exocrine system development GO:0035272 27 13 0,000 0,08841423 0,13647834 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,08841423 0,13638681 ! bone mineralization GO:0030282 15 13 0,000 0,08841423 0,1362954 ! regulation of exocytosis GO:0017157 17 13 0,000 0,08841423 0,13620411 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,08841423 0,13611294 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,08841423 0,13602189 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,08841423 0,13593097 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,08841423 0,13584017 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,08841423 0,13574949 ! genitalia development GO:0048806 15 13 0,000 0,08841423 0,13565893 ! regulation of cellular pH GO:0030641 20 13 0,000 0,08841423 0,13556849 ! cellular pigmentation GO:0033059 24 13 0,000 0,08841423 0,13547817 ! tissue regeneration GO:0042246 21 13 0,000 0,08841423 0,13538797 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,08841423 0,13529789 ! cofactor transport GO:0051181 19 13 0,000 0,08841423 0,13520793 ! NADP metabolic process GO:0006739 18 13 0,000 0,08841423 0,13511809 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,08841423 0,13502837 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,08841423 0,13493877 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08841423 0,13484929 ! gas transport GO:0015669 18 13 0,000 0,08841423 0,13475993 ! heme biosynthetic process GO:0006783 20 13 0,000 0,08841423 0,13467068 ! regulation of axon extension GO:0030516 23 13 0,000 0,08841423 0,13458156 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,08841423 0,13449255 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,08841423 0,13440366 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,08841423 0,13431488 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,08841423 0,13422623 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,08841423 0,13413769 ! muscle cell differentiation GO:0042692 104 71 1,000 0,09044544 0,13712888 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,09044544 0,13703854 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,09044544 0,13694833 ! monosaccharide catabolic process GO:0046365 91 71 1,000 0,09044544 0,13685823 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,09261355 0,1400468 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of transport GO:0051051 116 73 1,000 0,0947968 0,14325404 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,09488493 0,14329307 ! superoxide anion generation GO:0042554 18 14 0,000 0,09488493 0,14319904 ! neuron maturation GO:0042551 21 14 0,000 0,09488493 0,14310514 ! regulation of S phase GO:0033261 18 14 0,000 0,09488493 0,14301136 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09488493 0,14291771 ! myotube differentiation GO:0014902 21 14 0,000 0,09488493 0,14282417 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09488493 0,14273076 ! inositol metabolic process GO:0006020 20 14 0,000 0,09488493 0,14263748 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09488493 0,14254431 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09488493 0,14245127 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,09488493 0,14235834 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09488493 0,14226554 ! response to cAMP GO:0051591 19 14 0,000 0,09488493 0,14217286 ! limbic system development GO:0021761 25 14 0,000 0,09488493 0,1420803 ! startle response GO:0001964 21 14 0,000 0,09488493 0,14198786 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09488493 0,14189554 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,09488493 0,14180334 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09488493 0,14171126 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,09488493 0,1416193 ! glycine metabolic process GO:0006544 22 14 0,000 0,09488493 0,14152746 ! pituitary gland development GO:0021983 23 14 0,000 0,09488493 0,14143573 ! cellular response to starvation GO:0009267 21 14 0,000 0,09488493 0,14134413 ! lysosomal transport GO:0007041 20 14 0,000 0,09488493 0,14125265 ! regulation of heart rate GO:0002027 23 14 0,000 0,09488493 0,14116128 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09488493 0,14107003 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09488493 0,1409789 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,09488493 0,14088789 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,09488493 0,14079699 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,09488493 0,14070621 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09488493 0,14061555 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09488493 0,14052501 ! axon cargo transport GO:0008088 27 14 0,000 0,09488493 0,14043458 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09488493 0,14034427 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09488493 0,14025407 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,09488493 0,14016399 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,09488493 0,14007403 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09488493 0,13998418 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09488493 0,13989445 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09488493 0,13980483 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09488493 0,13971533 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09488493 0,13962594 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09488493 0,13953666 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09488493 0,1394475 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,09488493 0,13935845 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09488493 0,13926952 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,09488493 0,1391807 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09488493 0,13909199 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,09488493 0,1390034 ! cell killing GO:0001906 20 14 0,000 0,09488493 0,13891492 ! cilium assembly GO:0042384 20 14 0,000 0,09488493 0,13882655 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09488493 0,13873829 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,09699486 0,14173328 ! regulation of ligase activity GO:0051340 114 75 1,000 0,09920741 0,14487432 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10131007 0,14785098 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10131007 0,14775723 ! metencephalon development GO:0022037 19 15 0,000 0,10131007 0,14766359 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10131007 0,14757008 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10131007 0,14747668 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,10131007 0,1473834 ! skin development GO:0043588 25 15 0,000 0,10131007 0,14729023 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10131007 0,14719719 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10131007 0,14710426 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10131007 0,14701145 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10131007 0,14691876 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10131007 0,14682618 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10131007 0,14673372 ! adult walking behavior GO:0007628 25 15 0,000 0,10131007 0,14664138 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10131007 0,14654915 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10131007 0,14645704 ! myoblast differentiation GO:0045445 27 15 0,000 0,10131007 0,14636504 ! centrosome cycle GO:0007098 16 15 0,000 0,10131007 0,14627316 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10131007 0,1461814 ! response to osmotic stress GO:0006970 22 15 0,000 0,10131007 0,14608975 ! vesicle coating GO:0006901 25 15 0,000 0,10131007 0,14599821 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,10131007 0,14590679 ! DNA integration GO:0015074 22 15 0,000 0,10131007 0,14581549 ! peptide secretion GO:0002790 27 15 0,000 0,10131007 0,1457243 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10131007 0,14563322 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10131007 0,14554225 ! neuron recognition GO:0008038 22 15 0,000 0,10131007 0,1454514 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10131007 0,14536067 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10131007 0,14527004 ! biomineral formation GO:0031214 18 15 0,000 0,10131007 0,14517953 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10131007 0,14508913 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10131007 0,14499885 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10131007 0,14490868 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10131007 0,14481861 ! organic cation transport GO:0015695 19 15 0,000 0,10131007 0,14472866 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10131007 0,14463883 GO:0033014|tetrapyrrole biosynthetic process, ! defense response to virus GO:0051607 27 15 0,000 0,10131007 0,1445491 ! peptide hormone processing GO:0016486 19 15 0,000 0,10131007 0,14445949 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,10367476 0,14773974 ! protein ubiquitination GO:0016567 125 77 1,000 0,10367476 0,14764826 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,10367476 0,1475569 ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,10592894 0,15067196 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,10592894 0,15057884 ! protein secretion GO:0009306 27 16 0,000 0,10768996 0,15298758 ! hormone secretion GO:0046879 25 16 0,000 0,10768996 0,15289315 ! bone remodeling GO:0046849 24 16 0,000 0,10768996 0,15279883 ! endothelial cell migration GO:0043542 22 16 0,000 0,10768996 0,15270462 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,10768996 0,15261054 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10768996 0,15251656 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,10768996 0,15242271 ! patterning of blood vessels GO:0001569 24 16 0,000 0,10768996 0,15232897 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,10768996 0,15223534 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,10768996 0,15214183 ! protein polyubiquitination GO:0000209 26 16 0,000 0,10768996 0,15204843 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,10768996 0,15195515 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,10768996 0,15186199 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of protein binding GO:0043393 27 16 0,000 0,10768996 0,15176893 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,10768996 0,15167599 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,10768996 0,15158317 ! protein export from nucleus GO:0006611 24 16 0,000 0,10768996 0,15149046 ! negative regulation of immune response GO:0050777 28 16 0,000 0,10768996 0,15139786 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,10768996 0,15130537 ! DNA replication initiation GO:0006270 25 16 0,000 0,10768996 0,151213 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,10768996 0,15112074 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,10768996 0,1510286 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,10768996 0,15093656 ! diencephalon development GO:0021536 25 16 0,000 0,10768996 0,15084464 ! oogenesis GO:0048477 23 16 0,000 0,10768996 0,15075283 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,10768996 0,15066113 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,10768996 0,15056954 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,10768996 0,15047807 ! steroid catabolic process GO:0006706 22 16 0,000 0,10768996 0,1503867 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,10768996 0,15029545 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,10768996 0,1502043 ! sperm-egg recognition GO:0035036 16 16 0,000 0,10768996 0,15011327 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,10768996 0,15002235 ! nerve development GO:0021675 18 16 0,000 0,10768996 0,14993154 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,10768996 0,14984083 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,10768996 0,14975024 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,10819638 0,15036356 ! cellular respiration GO:0045333 107 79 1,000 0,10819638 0,15027276 ! T cell activation GO:0042110 134 79 1,000 0,10819638 0,15018207 ! regulation of lyase activity GO:0051339 133 79 1,000 0,10819638 0,15009149 ! alcohol catabolic process GO:0046164 104 80 1,000 0,1104768 0,15316254 ! forebrain development GO:0030900 131 80 1,000 0,1104768 0,15307027 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,1127699 0,15615338 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,1127699 0,15605942 GO:0002696|positive regulation of leukocyte activation, ! regulation of cell cycle process GO:0010564 122 81 1,000 0,1127699 0,15596558 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,11402492 0,15760656 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,11402492 0,1575119 ! negative regulation of defense response GO:0031348 19 17 0,000 0,11402492 0,15741735 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,11402492 0,15732292 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,11402492 0,1572286 ! glycerol metabolic process GO:0006071 20 17 0,000 0,11402492 0,1571344 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,11402492 0,15704031 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,11402492 0,15694633 ! signal complex assembly GO:0007172 29 17 0,000 0,11402492 0,15685246 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,11402492 0,1567587 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,11402492 0,15666506 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,11402492 0,15657153 ! memory GO:0007613 25 17 0,000 0,11402492 0,15647811 ! keratinization GO:0031424 17 17 0,000 0,11402492 0,1563848 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,11402492 0,1562916 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,11402492 0,15619852 ! retinoid metabolic process GO:0001523 22 17 0,000 0,11402492 0,15610554 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,11402492 0,15601268 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,11402492 0,15591992 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,11402492 0,15582728 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,11402492 0,15573475 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,11402492 0,15564232 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,11402492 0,15555001 ! membrane budding GO:0006900 29 17 0,000 0,11402492 0,1554578 ! heme metabolic process GO:0042168 27 17 0,000 0,11402492 0,15536571 ! actin filament bundle formation GO:0051017 26 17 0,000 0,11402492 0,15527372 ! neuromuscular junction development GO:0007528 23 17 0,000 0,11402492 0,15518184 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,11402492 0,15509007 ! body fluid secretion GO:0007589 27 17 0,000 0,11402492 0,15499841 ! stem cell differentiation GO:0048863 36 17 0,000 0,11402492 0,15490686 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,11402492 0,15481541 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,11402492 0,15472408 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,11402492 0,15463285 ! sensory perception of pain GO:0019233 23 17 0,000 0,11402492 0,15454173 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,11402492 0,15445071 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,11402492 0,15435981 ! synaptogenesis GO:0007416 24 17 0,000 0,11402492 0,15426901 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,11402492 0,15417831 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,11402492 0,15408773 ! cell-cell junction organization GO:0045216 25 17 0,000 0,11402492 0,15399725 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,11402492 0,15390687 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,11402492 0,1538166 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,11402492 0,15372644 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,11402492 0,15363639 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,11402492 0,15354644 ! detection of stimulus GO:0051606 108 82 1,000 0,11507538 0,15487031 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,11739296 0,15789696 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,12031526 0,16173297 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,12031526 0,1616385 ! positive regulation of translation GO:0045727 28 18 0,000 0,12031526 0,16154414 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12031526 0,16144989 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12031526 0,16135575 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12031526 0,16126172 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,12031526 0,1611678 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12031526 0,16107399 ! axis specification GO:0009798 26 18 0,000 0,12031526 0,16098028 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,12031526 0,16088669 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12031526 0,16079321 ! pancreas development GO:0031016 26 18 0,000 0,12031526 0,16069983 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12031526 0,16060656 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12031526 0,1605134 ! response to retinoic acid GO:0032526 25 18 0,000 0,12031526 0,16042035 ! pigmentation during development GO:0048066 31 18 0,000 0,12031526 0,16032741 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12031526 0,16023457 ! fucose metabolic process GO:0006004 26 18 0,000 0,12031526 0,16014185 ! response to fungus GO:0009620 19 18 0,000 0,12031526 0,16004922 ! peptide cross-linking GO:0018149 31 18 0,000 0,12031526 0,15995671 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12031526 0,1598643 ! heart process GO:0003015 27 18 0,000 0,12031526 0,159772 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12031526 0,15967981 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,12031526 0,15958772 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12031526 0,15949574 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12031526 0,15940386 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,12031526 0,1593121 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,12031526 0,15922043 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12031526 0,15912887 ! vitamin transport GO:0051180 24 18 0,000 0,12031526 0,15903742 ! hormone transport GO:0009914 27 18 0,000 0,12031526 0,15894607 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,12031526 0,15885483 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12031526 0,15876369 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,12031526 0,15867265 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12031526 0,15858172 ! cell-cell recognition GO:0009988 20 18 0,000 0,12031526 0,1584909 ! regulation of glucose import GO:0046324 21 18 0,000 0,12031526 0,15840018 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,12031526 0,15830956 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,12031526 0,15821904 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,12031526 0,15812863 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,12206328 0,1603344 ! rRNA metabolic process GO:0016072 107 85 1,000 0,12206328 0,16024288 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 1,000 0,12206328 0,16015147 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,12441546 0,16314456 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,12656131 0,16586382 ! positive regulation of ossification GO:0045778 30 19 0,000 0,12656131 0,16576937 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,12656131 0,16567502 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,12656131 0,16558078 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,12656131 0,16548665 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,12656131 0,16539262 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,12656131 0,1652987 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,12656131 0,16520489 ! regeneration GO:0031099 32 19 0,000 0,12656131 0,16511118 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,12656131 0,16501758 ! sensory perception of taste GO:0050909 23 19 0,000 0,12656131 0,16492408 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,12656131 0,1648307 ! smooth muscle contraction GO:0006939 36 19 0,000 0,12656131 0,16473741 ! peroxisome organization GO:0007031 29 19 0,000 0,12656131 0,16464424 ! digestive system process GO:0022600 30 19 0,000 0,12656131 0,16455116 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,12656131 0,1644582 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,12656131 0,16436534 ! response to vitamin A GO:0033189 26 19 0,000 0,12656131 0,16427258 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,12656131 0,16417993 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,12656131 0,16408738 ! response to starvation GO:0042594 30 19 0,000 0,12656131 0,16399494 ! sex determination GO:0007530 29 19 0,000 0,12656131 0,1639026 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,12656131 0,16381036 ! plasma membrane fusion GO:0045026 23 19 0,000 0,12656131 0,16371823 ! cytolysis GO:0019835 20 19 0,000 0,12656131 0,1636262 ! renal system process GO:0003014 35 19 0,000 0,12656131 0,16353428 ! vasodilation GO:0042311 33 19 0,000 0,12656131 0,16344245 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,12656131 0,16335073 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,12656131 0,16325912 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,12656131 0,16316761 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,12656131 0,1630762 ! sarcomere organization GO:0045214 23 19 0,000 0,12656131 0,16298489 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,12656131 0,16289368 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,12656131 0,16280258 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,12656131 0,16271158 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,12656131 0,16262068 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,12656131 0,16252988 ! protein stabilization GO:0050821 26 19 0,000 0,12656131 0,16243918 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,1291525 0,16567248 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 1,000 0,1291525 0,16558013 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,13153682 0,16854301 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,13153682 0,16844916 ! regulation of T cell activation GO:0050863 128 89 1,000 0,13153682 0,16835542 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,13276336 0,16983077 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,13276336 0,16973637 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,13276336 0,16964207 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,13276336 0,16954788 ! response to vitamin GO:0033273 29 20 0,000 0,13276336 0,16945379 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,13276336 0,1693598 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,13276336 0,16926592 ! response to ethanol GO:0045471 37 20 0,000 0,13276336 0,16917215 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,13276336 0,16907847 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,13276336 0,16898491 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,13276336 0,16889144 ! chromosome condensation GO:0030261 31 20 0,000 0,13276336 0,16879808 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,13276336 0,16870482 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,13276336 0,16861166 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,13276336 0,16851861 ! DNA modification GO:0006304 28 20 0,000 0,13276336 0,16842566 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,13276336 0,16833281 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,13276336 0,16824007 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,13276336 0,16814743 ! collagen catabolic process GO:0030574 25 20 0,000 0,13276336 0,16805488 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,13276336 0,16796244 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,13276336 0,16787011 ! alditol metabolic process GO:0019400 24 20 0,000 0,13276336 0,16777787 ! actin filament-based movement GO:0030048 34 20 0,000 0,13276336 0,16768574 ! leukocyte differentiation GO:0002521 143 90 1,000 0,13393133 0,16906808 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,13393133 0,16897534 ! ATP metabolic process GO:0046034 137 91 1,000 0,13633575 0,17191459 ! response to virus GO:0009615 122 91 1,000 0,13633575 0,17182039 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,13874983 0,17476704 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,13892172 0,17488777 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,13892172 0,1747921 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,13892172 0,17469653 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,13892172 0,17460107 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,13892172 0,17450571 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,13892172 0,17441046 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,13892172 0,17431531 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,13892172 0,17422026 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,13892172 0,17412532 ! phototransduction GO:0007602 25 21 0,000 0,13892172 0,17403048 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,13892172 0,17393574 ! ovarian follicle development GO:0001541 30 21 0,000 0,13892172 0,17384111 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,13892172 0,17374658 ! autophagy GO:0006914 28 21 0,000 0,13892172 0,17365215 ! cell aging GO:0007569 32 21 0,000 0,13892172 0,17355783 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,13892172 0,17346361 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,13892172 0,17336948 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,13892172 0,17327547 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,13892172 0,17318155 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,13892172 0,17308774 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,13892172 0,17299402 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,13892172 0,17290041 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,13892172 0,1728069 ! fatty acid transport GO:0015908 30 21 0,000 0,13892172 0,17271349 ! immunoglobulin production GO:0002377 33 21 0,000 0,13892172 0,17262018 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,13892172 0,17252698 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,13892172 0,17243387 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,13892172 0,17234086 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,13892172 0,17224796 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,13892172 0,17215515 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,13892172 0,17206245 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,13892172 0,17196984 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,13892172 0,17187733 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,13892172 0,17178493 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,13892172 0,17169262 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,13892172 0,17160041 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,13892172 0,1715083 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,13892172 0,17141629 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,14117332 0,17410114 ! response to oxidative stress GO:0006979 141 94 1,000 0,14360596 0,17700627 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,1450367 0,17867403 ! viral genome replication GO:0019079 29 22 0,000 0,1450367 0,17857838 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,1450367 0,17848284 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,1450367 0,17838739 ! leukocyte adhesion GO:0007159 38 22 0,000 0,1450367 0,17829205 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,1450367 0,17819681 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,1450367 0,17810167 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,1450367 0,17800663 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,1450367 0,17791169 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,1450367 0,17781685 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,1450367 0,17772212 ! ureteric bud development GO:0001657 32 22 0,000 0,1450367 0,17762749 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,1450367 0,17753295 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,1450367 0,17743852 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,1450367 0,17734419 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,1450367 0,17724996 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,1450367 0,17715583 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,1450367 0,17706179 ! blastocyst development GO:0001824 37 22 0,000 0,1450367 0,17696786 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,1450367 0,17687403 ! protein tetramerization GO:0051262 39 22 0,000 0,1450367 0,1767803 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,14849772 0,18090294 ! protein maturation GO:0051604 129 96 1,000 0,14849772 0,18080717 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,15095634 0,18370349 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,15110861 0,18379154 ! neuron fate commitment GO:0048663 32 23 0,000 0,15110861 0,1836944 ! embryonic pattern specification GO:0009880 31 23 0,000 0,15110861 0,18359736 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,15110861 0,18350042 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,15110861 0,18340359 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,15110861 0,18330686 ! vesicle targeting GO:0006903 32 23 0,000 0,15110861 0,18321023 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,15110861 0,1831137 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,15110861 0,18301727 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,15110861 0,18292095 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,15110861 0,18282472 ! interaction with host GO:0051701 37 23 0,000 0,15110861 0,1827286 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,15110861 0,18263258 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,15110861 0,18253666 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,15110861 0,18244084 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,15110861 0,18234512 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,15110861 0,1822495 ! cell fate determination GO:0001709 45 23 0,000 0,15110861 0,18215398 ! pentose metabolic process GO:0019321 31 23 0,000 0,15110861 0,18205856 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,15110861 0,18196325 ! spermatid development GO:0007286 33 23 0,000 0,15110861 0,18186803 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,15110861 0,18177291 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,15110861 0,18167789 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,15110861 0,18158297 ! telomere organization GO:0032200 32 23 0,000 0,15110861 0,18148815 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,15110861 0,18139342 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,15110861 0,1812988 ! regulation of amine transport GO:0051952 38 23 0,000 0,15110861 0,18120428 ! extracellular structure organization GO:0043062 156 99 1,000 0,15589789 0,18685 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,15713774 0,18823791 ! initiation of viral infection GO:0019059 42 24 0,000 0,15713774 0,18813992 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,15713774 0,18804204 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,15713774 0,18794425 ! superoxide metabolic process GO:0006801 32 24 0,000 0,15713774 0,18784657 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,15713774 0,18774898 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,15713774 0,1876515 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,15713774 0,18755412 ! sperm motility GO:0030317 27 24 0,000 0,15713774 0,18745684 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,15713774 0,18735966 ! vacuole organization GO:0007033 39 24 0,000 0,15713774 0,18726259 ! receptor metabolic process GO:0043112 37 24 0,000 0,15713774 0,18716561 ! response to toxin GO:0009636 38 24 0,000 0,15713774 0,18706873 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,15713774 0,18697196 ! base-excision repair GO:0006284 31 24 0,000 0,15713774 0,18687528 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,15713774 0,1867787 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,15713774 0,18668223 ! glutathione metabolic process GO:0006749 29 24 0,000 0,15713774 0,18658585 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,15713774 0,18648957 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,15713774 0,18639339 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,15713774 0,18629732 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,16312438 0,19329525 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,16312438 0,19319572 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,16312438 0,19309629 ! peptide transport GO:0015833 43 25 0,000 0,16312438 0,19299696 ! male gonad development GO:0008584 33 25 0,000 0,16312438 0,19289773 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,16312438 0,19279861 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,16312438 0,19269958 ! phospholipid transport GO:0015914 35 25 0,000 0,16312438 0,19260066 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,16312438 0,19250184 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,16312438 0,19240312 ! detection of light stimulus GO:0009583 30 25 0,000 0,16312438 0,1923045 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,16312438 0,19220599 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,16312438 0,19210757 ! leukocyte proliferation GO:0070661 39 25 0,000 0,16312438 0,19200926 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,16906885 0,19890453 ! translational initiation GO:0006413 43 26 0,000 0,16906885 0,19880284 ! regulation of pH GO:0006885 36 26 0,000 0,16906885 0,19870126 ! circadian rhythm GO:0007623 42 26 0,000 0,16906885 0,19859978 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,16906885 0,1984984 ! post-embryonic development GO:0009791 42 26 0,000 0,16906885 0,19839712 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,16906885 0,19829595 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,16906885 0,19819488 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,16906885 0,19809392 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,16906885 0,19799306 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,16906885 0,1978923 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,17497143 0,204697 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,17497143 0,20459293 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,17497143 0,20448897 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,17497143 0,20438512 ! catechol metabolic process GO:0009712 43 27 0,000 0,17497143 0,20428137 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,17497143 0,20417773 ! acute-phase response GO:0006953 42 27 0,000 0,17497143 0,20407419 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,17497143 0,20397075 ! myofibril assembly GO:0030239 36 27 0,000 0,17497143 0,20386743 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,17497143 0,2037642 ! response to ionizing radiation GO:0010212 47 27 0,000 0,17497143 0,20366108 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,17497143 0,20355807 ! natural killer cell activation GO:0030101 35 27 0,000 0,17497143 0,20345516 ! lipid oxidation GO:0034440 38 27 0,000 0,17497143 0,20335235 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,17497143 0,20324965 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,17497143 0,20314705 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,18083242 0,2098459 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,18083242 0,20974008 ! phenol metabolic process GO:0018958 44 28 0,000 0,18083242 0,20963436 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,18083242 0,20952875 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,18083242 0,20942325 ! cell junction assembly GO:0034329 56 28 0,000 0,18083242 0,20931785 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,18083242 0,20921256 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,18083242 0,20910738 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,18083242 0,2090023 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,18083242 0,20889732 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,18083242 0,20879246 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,18083242 0,20868769 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,18083242 0,20858303 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,18083242 0,20847848 ! mesoderm formation GO:0001707 46 28 0,000 0,18083242 0,20837403 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,18083242 0,20826969 ! BMP signaling pathway GO:0030509 40 28 0,000 0,18083242 0,20816545 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,18083242 0,20806132 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,18083242 0,20795729 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,18665211 0,21454265 ! regulation of innate immune response GO:0045088 38 29 0,000 0,18665211 0,21443549 ! ovulation cycle process GO:0022602 41 29 0,000 0,18665211 0,21432843 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,18665211 0,21422148 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,18665211 0,21411464 ! mismatch repair GO:0006298 34 29 0,000 0,18665211 0,2140079 ! muscle cell development GO:0055001 38 29 0,000 0,18665211 0,21390127 ! formation of primary germ layer GO:0001704 48 29 0,000 0,18665211 0,21379474 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,18665211 0,21368833 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,18665211 0,21358201 ! tissue homeostasis GO:0001894 42 29 0,000 0,18665211 0,21347581 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,19243078 0,21997554 ! organic anion transport GO:0015711 51 30 0,000 0,19243078 0,21986626 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,19243078 0,21975709 ! spliceosome assembly GO:0000245 49 30 0,000 0,19243078 0,21964803 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,19243078 0,21953908 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,19243078 0,21943024 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,19243078 0,2193215 ! ceramide metabolic process GO:0006672 43 30 0,000 0,19243078 0,21921287 ! ovulation cycle GO:0042698 43 30 0,000 0,19243078 0,21910435 ! hindbrain development GO:0030902 45 30 0,000 0,19243078 0,21899594 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,19243078 0,21888763 ! adult locomotory behavior GO:0008344 47 30 0,000 0,19243078 0,21877943 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,19243078 0,21867134 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,19243078 0,21856335 ! negative regulation of secretion GO:0051048 49 31 0,000 0,19816872 0,22496943 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,19816872 0,22485844 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,19816872 0,22474756 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,19816872 0,2246368 ! odontogenesis GO:0042476 50 31 0,000 0,19816872 0,22452614 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,19816872 0,22441559 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,19816872 0,22430515 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,19816872 0,22419481 ! cell fate specification GO:0001708 37 31 0,000 0,19816872 0,22408459 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,19816872 0,22397448 ! RNA modification GO:0009451 40 31 0,000 0,19816872 0,22386447 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,20386622 0,23018768 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,20386622 0,23007473 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,20386622 0,2299619 ! meiosis I GO:0007127 52 32 0,000 0,20386622 0,22984917 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,20386622 0,22973655 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,20386622 0,22962405 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,20386622 0,22951165 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,20386622 0,22939937 ! cytokine production GO:0001816 44 32 0,000 0,20386622 0,22928719 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,20386622 0,22917513 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,20386622 0,22906317 ! vesicle localization GO:0051648 47 32 0,000 0,20386622 0,22895132 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,20952356 0,23518994 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,20952356 0,23507522 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,20952356 0,2349606 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,20952356 0,2348461 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,20952356 0,23473171 ! sister chromatid segregation GO:0000819 46 33 0,000 0,20952356 0,23461743 ! actomyosin structure organization GO:0031032 43 33 0,000 0,20952356 0,23450326 ! cell junction organization GO:0034330 63 33 0,000 0,20952356 0,2343892 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,20952356 0,23427525 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,20952356 0,23416141 ! female gonad development GO:0008585 49 33 0,000 0,20952356 0,23404769 ! positive regulation of cell development GO:0010720 54 33 0,000 0,20952356 0,23393407 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,20952356 0,23382057 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,20952356 0,23370717 ! mRNA catabolic process GO:0006402 48 34 0,000 0,21514102 0,23985669 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,21514102 0,23974048 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,21514102 0,23962438 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,21514102 0,2395084 ! feeding behavior GO:0007631 45 34 0,000 0,21514102 0,23939253 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,21514102 0,23927677 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,21514102 0,23916112 ! female gamete generation GO:0007292 43 34 0,000 0,21514102 0,23904558 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,21514102 0,23893016 ! polyol metabolic process GO:0019751 44 34 0,000 0,21514102 0,23881484 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,21514102 0,23869964 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,21514102 0,23858455 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,22071888 0,24465226 ! Notch signaling pathway GO:0007219 56 35 0,000 0,22071888 0,24453441 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,22071888 0,24441667 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,22071888 0,24429905 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,22071888 0,24418154 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,22071888 0,24406415 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,22071888 0,24394687 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,22071888 0,2438297 ! pigment metabolic process GO:0042440 61 35 0,000 0,22071888 0,24371264 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,22625742 0,24970829 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,22625742 0,24958852 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,22625742 0,24946887 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,22625742 0,24934934 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,22625742 0,24922992 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,22625742 0,24911061 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,22625742 0,24899142 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,23175691 0,25492152 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,23175691 0,25479966 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,23175691 0,25467792 ! ion transmembrane transport GO:0034220 56 37 0,000 0,23175691 0,2545563 ! regulation of protein secretion GO:0050708 51 37 0,000 0,23175691 0,25443479 ! amino acid activation GO:0043038 52 37 0,000 0,23175691 0,2543134 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,23175691 0,25419213 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,23721762 0,26005745 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,23721762 0,25993355 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,23721762 0,25980978 ! phagocytosis GO:0006909 60 38 0,000 0,23721762 0,25968612 ! maintenance of location in cell GO:0051651 69 38 0,000 0,23721762 0,25956257 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,24263983 0,26536929 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,24263983 0,26524316 ! male sex differentiation GO:0046661 53 39 0,000 0,24263983 0,26511716 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,24263983 0,26499127 ! chromatin remodeling GO:0006338 68 39 0,000 0,24263983 0,2648655 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,24263983 0,26473985 ! JNK cascade GO:0007254 54 39 0,000 0,24263983 0,26461433 ! cell growth GO:0016049 61 39 0,000 0,24263983 0,26448892 ! synapse organization GO:0050808 55 39 0,000 0,24263983 0,26436363 ! response to calcium ion GO:0051592 58 40 0,000 0,24802381 0,27010168 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,24802381 0,26997385 ! regulation of tube size GO:0035150 60 40 0,000 0,24802381 0,26984615 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,24802381 0,26971856 ! peptide metabolic process GO:0006518 56 40 0,000 0,24802381 0,26959109 ! inner ear development GO:0048839 57 40 0,000 0,24802381 0,26946375 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,24802381 0,26933652 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,24802381 0,26920942 ! B cell differentiation GO:0030183 62 40 0,000 0,24802381 0,26908243 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,24802381 0,26895556 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,25336981 0,27462326 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,25336981 0,27449391 ! endosome transport GO:0016197 71 41 0,000 0,25336981 0,27436467 ! striated muscle contraction GO:0006941 62 41 0,000 0,25336981 0,27423556 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,25336981 0,27410657 ! biopolymer methylation GO:0043414 62 41 0,000 0,25336981 0,2739777 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,25336981 0,27384895 ! mitochondrial transport GO:0006839 60 42 0,000 0,25867812 0,27945499 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,25867812 0,27932379 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,25867812 0,27919271 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,25867812 0,27906176 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,25867812 0,27893093 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,25867812 0,27880022 ! excretion GO:0007588 63 42 0,000 0,25867812 0,27866963 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,25867812 0,27853917 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,25867812 0,27840883 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,25867812 0,27827861 ! neuromuscular process GO:0050905 79 43 0,000 0,26394898 0,28381611 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,26394898 0,28368349 ! tRNA processing GO:0008033 49 43 0,000 0,26394898 0,28355099 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,26394898 0,28341861 ! methylation GO:0032259 64 43 0,000 0,26394898 0,28328636 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,26918267 0,28876873 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,26918267 0,2886341 ! regulation of ion transport GO:0043269 57 44 0,000 0,26918267 0,2884996 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,26918267 0,28836523 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,26918267 0,28823098 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,26918267 0,28809686 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,26918267 0,28796286 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,26918267 0,28782899 ! RNA catabolic process GO:0006401 64 45 0,000 0,27437945 0,29324941 ! positive regulation of defense response GO:0031349 59 45 0,000 0,27437945 0,29311321 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,27437945 0,29297713 ! cell recognition GO:0008037 58 45 0,000 0,27437945 0,29284117 ! cell maturation GO:0048469 60 45 0,000 0,27437945 0,29270535 ! cell redox homeostasis GO:0045454 63 46 0,000 0,27953956 0,29807186 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,27953956 0,29793373 ! regulation of ossification GO:0030278 71 46 0,000 0,27953956 0,29779574 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,27953956 0,29765787 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,28466328 0,30297341 ! viral infectious cycle GO:0019058 71 47 0,000 0,28466328 0,30283328 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,28466328 0,30269327 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,28466328 0,30255339 ! chloride transport GO:0006821 67 48 0,000 0,28975085 0,30781845 ! gastrulation GO:0007369 73 48 0,000 0,28975085 0,30767634 ! regulation of DNA replication GO:0006275 75 48 0,000 0,28975085 0,30753436 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,28975085 0,3073925 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,28975085 0,30725078 ! nuclear export GO:0051168 69 48 0,000 0,28975085 0,30710919 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,29480252 0,31231958 ! sensory perception of smell GO:0007608 61 49 0,000 0,29480252 0,31217578 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,29480252 0,31203212 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,29480252 0,31188859 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,29480252 0,3117452 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,29480252 0,31160193 ! maintenance of location GO:0051235 84 49 0,000 0,29480252 0,3114588 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,29981855 0,3166128 ! proton transport GO:0015992 75 50 0,000 0,29981855 0,3164675 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,29981855 0,31632233 ! positive regulation of secretion GO:0051047 71 51 0,000 0,30479919 0,32142969 ! hydrogen transport GO:0006818 77 51 0,000 0,30479919 0,32128238 ! muscle fiber development GO:0048747 74 51 0,000 0,30479919 0,3211352 ! adult behavior GO:0030534 80 51 0,000 0,30479919 0,32098816 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,30974469 0,32604704 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,30974469 0,32589789 ! establishment of organelle localization GO:0051656 85 52 0,000 0,30974469 0,32574887 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,31465528 0,33076195 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,31465528 0,33061085 ! single fertilization GO:0007338 59 53 0,000 0,31465528 0,33045988 ! amino acid transport GO:0006865 84 54 0,000 0,31953122 0,33542757 ! regulation of mitosis GO:0007088 84 54 0,000 0,31953122 0,33527455 GO:0051783|regulation of nuclear division, ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,31953122 0,33512166 ! exocytosis GO:0006887 74 55 0,000 0,32437275 0,34004436 ! mesoderm development GO:0007498 76 55 0,000 0,32437275 0,33988944 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,32437275 0,33973466 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,33395353 0,34960997 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,33395353 0,34945091 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,33395353 0,349292 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,33395353 0,34913323 ! secondary metabolic process GO:0019748 84 57 0,000 0,33395353 0,34897461 ! gonad development GO:0008406 79 57 0,000 0,33395353 0,34881613 ! viral reproductive process GO:0022415 87 58 0,000 0,33869325 0,35360621 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,33869325 0,35344577 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,33869325 0,35328548 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,34339952 0,35803214 ! activation of MAPK activity GO:0000187 84 59 0,000 0,34339952 0,35786992 ! actin filament organization GO:0007015 95 59 0,000 0,34339952 0,35770784 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,34339952 0,3575459 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,34807257 0,36224747 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,34807257 0,36208363 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,34807257 0,36191994 ! regulation of heart contraction GO:0008016 91 60 0,000 0,34807257 0,3617564 ! fertilization GO:0009566 68 60 0,000 0,34807257 0,361593 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,35271262 0,36624787 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,35271262 0,36608259 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,35271262 0,36591747 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,35271262 0,36575249 ! neurotransmitter transport GO:0006836 81 62 0,000 0,35731991 0,37036314 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,35731991 0,37019631 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,35731991 0,37002963 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,35731991 0,3698631 ! organelle localization GO:0051640 96 62 0,000 0,35731991 0,36969672 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,36189467 0,37426158 ! viral reproduction GO:0016032 92 63 0,000 0,36189467 0,37409337 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,36643713 0,37861878 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,36643713 0,37844877 ! reproductive structure development GO:0048608 90 65 0,000 0,37094751 0,38293504 ! B cell activation GO:0042113 104 65 0,000 0,37094751 0,38276325 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,37094751 0,3825916 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,37094751 0,38242011 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,37094751 0,38224878 ! activation of immune response GO:0002253 83 65 0,000 0,37094751 0,3820776 ! antigen processing and presentation GO:0019882 96 66 0,000 0,37542604 0,38651741 ! axon guidance GO:0007411 99 66 0,000 0,37542604 0,38634447 ! regulation of immune effector process GO:0002697 101 66 0,000 0,37542604 0,38617168 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,37987294 0,39057119 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,37987294 0,39039667 ! acute inflammatory response GO:0002526 92 68 0,000 0,38428843 0,3947581 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,38428843 0,39458187 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,38428843 0,39440579 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,38428843 0,39422987 ! rhythmic process GO:0048511 105 68 0,000 0,38428843 0,39405411 ! inorganic anion transport GO:0015698 93 68 0,000 0,38428843 0,39387851 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,38867273 0,39819478 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,38867273 0,39801749 ! response to drug GO:0042493 108 69 0,000 0,38867273 0,39784035 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,38867273 0,39766338 ! response to metal ion GO:0010038 103 70 0,000 0,39302606 0,40193861 ! amine transport GO:0015837 101 70 0,000 0,39302606 0,40175997 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,39734864 0,40599817 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,39734864 0,40581788 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,40164068 0,41001934 ! regulation of blood pressure GO:0008217 107 73 0,000 0,4059024 0,41418613 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,4059024 0,41400245 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,4059024 0,41381894 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,41013401 0,41794782 ! digestion GO:0007586 97 74 0,000 0,41013401 0,41776273 ! blood coagulation GO:0007596 116 75 0,000 0,41433573 0,42185576 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,41433573 0,4216691 ! response to nutrient GO:0007584 104 75 0,000 0,41433573 0,4214826 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,41433573 0,42129627 ! amine biosynthetic process GO:0009309 97 76 0,000 0,41850775 0,42535034 ! tRNA metabolic process GO:0006399 95 76 0,000 0,41850775 0,42516246 ! response to unfolded protein GO:0006986 99 76 0,000 0,41850775 0,42497475 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,42265029 0,42899191 ! sex differentiation GO:0007548 105 77 0,000 0,42265029 0,42880267 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,42265029 0,42861361 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,42265029 0,42842471 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,42676355 0,4324036 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,43084774 0,43634954 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,43084774 0,43615749 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,43490307 0,4400691 GO:0010498|proteasomal protein catabolic process, ! hemostasis GO:0007599 125 81 0,000 0,43892974 0,44394828 ! mRNA transport GO:0051028 121 81 0,000 0,43892974 0,44375314 ! response to protein stimulus GO:0051789 111 81 0,000 0,43892974 0,44355817 ! regulation of neurological system process GO:0031644 122 81 0,000 0,43892974 0,44336337 ! vitamin metabolic process GO:0006766 103 81 0,000 0,43892974 0,44316874 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,44689788 0,45101585 ! regulation of defense response GO:0031347 117 84 0,000 0,45083975 0,45479449 ! sterol metabolic process GO:0016125 120 84 0,000 0,45083975 0,4545951 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,45475376 0,45834077 ! cellular defense response GO:0006968 102 87 0,000 0,46249894 0,46594287 ! female pregnancy GO:0007565 130 87 0,000 0,46249894 0,46573887 ! establishment of RNA localization GO:0051236 128 88 0,000 0,46633051 0,46939176 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! reproductive developmental process GO:0003006 127 89 0,000 0,47013499 0,4730142 ! hormone metabolic process GO:0042445 121 90 0,000 0,47391256 0,47660642 ! RNA localization GO:0006403 135 91 0,000 0,47766341 0,48016864 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,48138773 0,48370109 ! cell fate commitment GO:0045165 141 92 0,000 0,48138773 0,48348986 ! positive regulation of immune response GO:0050778 121 92 0,000 0,48138773 0,48327883 ! DNA recombination GO:0006310 146 92 0,000 0,48138773 0,48306797 ! sulfur metabolic process GO:0006790 118 92 0,000 0,48138773 0,4828573 ! electron transport chain GO:0022900 123 94 0,000 0,48875754 0,4900359 ! carboxylic acid transport GO:0046942 147 95 0,000 0,49240339 0,49347617 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,49602345 0,49688761 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,4996179 0,50027043 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! homophilic cell adhesion GO:0007156 149 100 0,000 0,51024938 0,51069346 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,51024938 0,51047132 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,51024938 0,51024938