pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1203-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of protein kinase activity GO:0006469 130 67 8,000 1,868E-10 4,494E-07 ! interphase of mitotic cell cycle GO:0051329 209 95 9,000 2,113E-10 2,542E-07 ! negative regulation of kinase activity GO:0033673 131 68 8,000 2,142E-10 1,718E-07 ! interphase GO:0051325 213 98 9,000 2,886E-10 1,736E-07 ! negative regulation of transferase activity GO:0051348 140 72 8,000 3,627E-10 1,746E-07 ! protein amino acid autophosphorylation GO:0046777 141 60 7,000 2,092E-09 8,389E-07 ! regulation of endothelial cell proliferation GO:0001936 57 26 5,000 7,134E-09 2,452E-06 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 6,000 8,426E-09 2,534E-06 ! G1 phase GO:0051318 40 19 4,000 6,617E-08 1,769E-05 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 4,000 8,782E-08 2,113E-05 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 3,000 1,326E-07 2,9E-05 ! gas homeostasis GO:0033483 16 9 3,000 1,326E-07 2,658E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 3,000 2,2E-07 4,071E-05 ! negative regulation of MAPKKK cascade GO:0043409 20 10 3,000 2,2E-07 3,781E-05 ! vasculogenesis GO:0001570 46 25 4,000 2,94E-07 4,715E-05 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 3,000 3,441E-07 5,175E-05 ! response to hypoxia GO:0001666 171 81 6,000 4,619E-07 6,537E-05 ! response to oxygen levels GO:0070482 176 83 6,000 5,462E-07 7,301E-05 ! regulation of monooxygenase activity GO:0032768 33 13 3,000 7,389E-07 9,357E-05 ! negative regulation of protein kinase cascade GO:0010741 68 30 4,000 7,703E-07 9,267E-05 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 5,000 9,696E-07 1,111E-04 ! transcription initiation GO:0006352 153 94 6,000 1,277E-06 1,396E-04 ! epithelial to mesenchymal transition GO:0001837 28 15 3,000 1,398E-06 1,462E-04 ! G1 phase of mitotic cell cycle GO:0000080 35 16 3,000 1,856E-06 1,86E-04 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 3,000 1,856E-06 1,786E-04 ! peptidyl-histidine phosphorylation GO:0018106 9 5 2,000 1,879E-06 1,739E-04 ! positive regulation of vasoconstriction GO:0045907 9 5 2,000 1,879E-06 1,675E-04 ! regulation of keratinocyte differentiation GO:0045616 6 5 2,000 1,879E-06 1,615E-04 ! tissue remodeling GO:0048771 76 37 4,000 2,28E-06 1,892E-04 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 2,000 3,743E-06 3,002E-04 ! positive regulation of microtubule polymerization GO:0031116 13 6 2,000 3,743E-06 2,905E-04 ! apoptotic mitochondrial changes GO:0008637 41 20 3,000 4,851E-06 3,647E-04 ! induction of apoptosis by intracellular signals GO:0008629 93 45 4,000 6,157E-06 4,489E-04 ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 5,000 6,208E-06 4,393E-04 ! regulation of lipid kinase activity GO:0043550 13 7 2,000 6,522E-06 4,483E-04 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 2,000 6,522E-06 4,359E-04 ! positive regulation of monooxygenase activity GO:0032770 12 7 2,000 6,522E-06 4,241E-04 ! peptidyl-histidine modification GO:0018202 16 7 2,000 6,522E-06 4,13E-04 ! regulation of epidermal cell differentiation GO:0045604 8 7 2,000 6,522E-06 4,024E-04 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 2,000 6,522E-06 3,923E-04 ! regulation of microtubule polymerization GO:0031113 15 7 2,000 6,522E-06 3,827E-04 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 3,000 7,258E-06 4,158E-04 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 3,000 7,258E-06 4,061E-04 ! regulation of cell-matrix adhesion GO:0001952 78 23 3,000 8,747E-06 4,783E-04 GO:0010810|regulation of cell-substrate adhesion, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 2,000 1,039E-05 5,556E-04 ! UTP metabolic process GO:0046051 8 8 2,000 1,039E-05 5,435E-04 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 1,039E-05 5,319E-04 ! positive regulation of epidermis development GO:0045684 13 8 2,000 1,039E-05 5,208E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 2,000 1,039E-05 5,102E-04 ! regulation of oxidoreductase activity GO:0051341 46 24 3,000 1,045E-05 5,028E-04 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 4,000 1,151E-05 5,431E-04 ! regulation of protein polymerization GO:0032271 103 53 4,000 1,393E-05 6,446E-04 ! regulation of epithelial cell differentiation GO:0030856 14 9 2,000 1,552E-05 7,046E-04 ! CTP metabolic process GO:0046036 9 9 2,000 1,552E-05 6,915E-04 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! GTP metabolic process GO:0046039 9 9 2,000 1,552E-05 6,789E-04 ! RNA elongation GO:0006354 79 55 4,000 1,673E-05 7,189E-04 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 2,208E-05 9,319E-04 ! regulation of bone resorption GO:0045124 25 10 2,000 2,208E-05 9,158E-04 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 2,000 2,208E-05 9,003E-04 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 2,000 2,208E-05 8,853E-04 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 2,000 2,208E-05 8,708E-04 ! cellular iron ion homeostasis GO:0006879 51 29 3,000 2,283E-05 8,861E-04 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 3,000 2,283E-05 8,721E-04 ! cell cycle arrest GO:0007050 213 100 5,000 2,595E-05 9,754E-04 ! regulation of protein complex assembly GO:0043254 117 61 4,000 2,783E-05 1,03E-03 ! iron ion homeostasis GO:0055072 54 31 3,000 2,998E-05 1,093E-03 ! regulation of homeostatic process GO:0032844 134 62 4,000 3,013E-05 1,082E-03 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 2,000 3,023E-05 1,07E-03 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 22 11 2,000 3,023E-05 1,054E-03 ! regulation of lipid metabolic process GO:0019216 115 63 4,000 3,257E-05 1,119E-03 ! steroid hormone receptor signaling pathway GO:0030518 129 63 4,000 3,257E-05 1,104E-03 ! negative regulation of MAP kinase activity GO:0043407 69 32 3,000 3,411E-05 1,14E-03 ! positive regulation of cellular catabolic process GO:0031331 31 12 2,000 4,013E-05 1,323E-03 ! regulation of B cell proliferation GO:0030888 20 12 2,000 4,013E-05 1,305E-03 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 2,000 4,013E-05 1,287E-03 ! gland morphogenesis GO:0022612 29 12 2,000 4,013E-05 1,27E-03 ! peptidyl-lysine modification GO:0018205 21 12 2,000 4,013E-05 1,254E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 2,000 4,013E-05 1,238E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 4,000 4,719E-05 1,437E-03 ! regulation of microtubule-based process GO:0032886 78 35 3,000 4,9E-05 1,474E-03 ! negative regulation of cell size GO:0045792 134 69 4,000 5,064E-05 1,504E-03 ! lipid localization GO:0010876 28 13 2,000 5,195E-05 1,524E-03 GO:0019915|lipid storage, ! regulation of epidermis development GO:0045682 19 13 2,000 5,195E-05 1,506E-03 ! positive regulation of protein polymerization GO:0032273 25 13 2,000 5,195E-05 1,488E-03 ! androgen receptor signaling pathway GO:0030521 74 36 3,000 5,487E-05 1,553E-03 ! glycogen metabolic process GO:0005977 61 37 3,000 6,125E-05 1,714E-03 ! positive regulation of GTPase activity GO:0043547 36 14 2,000 6,584E-05 1,821E-03 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 2,000 6,584E-05 1,8E-03 ! glucan metabolic process GO:0044042 62 38 3,000 6,815E-05 1,842E-03 GO:0006073|cellular glucan metabolic process, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 2,000 8,195E-05 2,191E-03 ! regulation of vasodilation GO:0042312 26 15 2,000 8,195E-05 2,167E-03 ! positive regulation of oxidoreductase activity GO:0051353 22 15 2,000 8,195E-05 2,143E-03 ! muscle maintenance GO:0046716 26 15 2,000 8,195E-05 2,12E-03 ! mesenchymal cell development GO:0014031 87 40 3,000 8,362E-05 2,14E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! ribonucleoside metabolic process GO:0009119 55 40 3,000 8,362E-05 2,118E-03 ! regulation of peptidase activity GO:0052547 134 79 4,000 9,694E-05 2,43E-03 ! energy reserve metabolic process GO:0006112 74 43 3,000 1,114E-04 2,763E-03 ! regulation of epithelial cell proliferation GO:0050678 111 43 3,000 1,114E-04 2,735E-03 ! positive regulation of protein complex assembly GO:0031334 32 17 2,000 1,214E-04 2,951E-03 ! regulation of survival gene product expression GO:0045884 33 17 2,000 1,214E-04 2,922E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 2,000 1,214E-04 2,893E-03 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 2,000 1,214E-04 2,864E-03 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 2,000 1,214E-04 2,837E-03 ! JAK-STAT cascade GO:0007259 71 44 3,000 1,22E-04 2,822E-03 ! negative regulation of growth GO:0045926 155 84 4,000 1,297E-04 2,973E-03 ! mitochondrion organization GO:0007005 148 86 4,000 1,45E-04 3,291E-03 ! positive regulation of anti-apoptosis GO:0045768 39 18 2,000 1,451E-04 3,263E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 1,451E-04 3,233E-03 ! positive regulation of DNA binding GO:0043388 73 47 3,000 1,581E-04 3,491E-03 ! regulation of DNA binding GO:0051101 155 88 4,000 1,616E-04 3,535E-03 ! regulation of endothelial cell migration GO:0010594 44 19 2,000 1,716E-04 3,719E-03 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 2,000 1,716E-04 3,686E-03 ! cellular component disassembly GO:0022411 86 48 3,000 1,717E-04 3,657E-03 ! regulation of fatty acid metabolic process GO:0019217 38 20 2,000 2,01E-04 4,242E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 2,01E-04 4,205E-03 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 2,000 2,01E-04 4,169E-03 ! positive regulation of binding GO:0051099 78 51 3,000 2,176E-04 4,475E-03 ! inactivation of MAPK activity GO:0000188 39 21 2,000 2,335E-04 4,761E-03 ! cell structure disassembly during apoptosis GO:0006921 30 21 2,000 2,335E-04 4,721E-03 ! regulation of vasoconstriction GO:0019229 39 21 2,000 2,335E-04 4,682E-03 ! response to UV GO:0009411 104 53 3,000 2,527E-04 5,025E-03 ! positive regulation of cytoskeleton organization GO:0051495 48 22 2,000 2,692E-04 5,31E-03 ! apoptotic nuclear changes GO:0030262 32 22 2,000 2,692E-04 5,266E-03 ! cellular polysaccharide metabolic process GO:0044264 86 55 3,000 2,917E-04 5,66E-03 ! regulation of anti-apoptosis GO:0045767 53 23 2,000 3,083E-04 5,934E-03 ! activation of pro-apoptotic gene products GO:0008633 47 23 2,000 3,083E-04 5,887E-03 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 2,000 3,083E-04 5,841E-03 ! hemoglobin biosynthetic process GO:0042541 7 5 1,000 3,281E-04 6,167E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,281E-04 6,12E-03 ! transcription from mitochondrial promoter GO:0006390 7 5 1,000 3,281E-04 6,073E-03 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 1,000 3,281E-04 6,026E-03 ! positive regulation of glycolysis GO:0045821 14 5 1,000 3,281E-04 5,981E-03 ! anagen GO:0042640 6 5 1,000 3,281E-04 5,936E-03 ! smooth muscle tissue development GO:0048745 28 5 1,000 3,281E-04 5,891E-03 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 1,000 3,281E-04 5,848E-03 GO:0046516|hypusine metabolic process, ! negative regulation of survival gene product expression GO:0008634 8 5 1,000 3,281E-04 5,805E-03 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 1,000 3,281E-04 5,762E-03 ! microvillus organization GO:0032528 7 5 1,000 3,281E-04 5,721E-03 GO:0030033|microvillus assembly, ! mRNA transcription GO:0009299 9 5 1,000 3,281E-04 5,679E-03 ! response to food GO:0032094 6 5 1,000 3,281E-04 5,639E-03 ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 3,281E-04 5,599E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 1,000 3,281E-04 5,559E-03 ! forebrain morphogenesis GO:0048853 13 5 1,000 3,281E-04 5,52E-03 ! positive regulation of chemokine production GO:0032722 8 5 1,000 3,281E-04 5,482E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 3,281E-04 5,444E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 3,281E-04 5,407E-03 GO:0022011|myelination in the peripheral nervous system, ! stem cell division GO:0017145 11 5 1,000 3,281E-04 5,37E-03 GO:0048103|somatic stem cell division, ! positive regulation of cell migration GO:0030335 126 57 3,000 3,348E-04 5,443E-03 ! protein import into nucleus, translocation GO:0000060 46 24 2,000 3,508E-04 5,665E-03 ! regulation of cellular catabolic process GO:0031329 52 24 2,000 3,508E-04 5,628E-03 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 2,000 3,508E-04 5,59E-03 ! negative regulation of phosphorylation GO:0042326 47 24 2,000 3,508E-04 5,554E-03 ! membrane depolarization GO:0051899 39 24 2,000 3,508E-04 5,517E-03 ! regulation of smooth muscle contraction GO:0006940 43 25 2,000 3,97E-04 6,203E-03 ! regulation of blood coagulation GO:0030193 40 25 2,000 3,97E-04 6,163E-03 ! neural tube closure GO:0001843 49 25 2,000 3,97E-04 6,123E-03 GO:0060606|tube closure, ! nucleoside metabolic process GO:0009116 81 60 3,000 4,078E-04 6,25E-03 ! tube lumen formation GO:0035148 50 26 2,000 4,469E-04 6,805E-03 ! insulin receptor signaling pathway GO:0008286 64 26 2,000 4,469E-04 6,762E-03 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 2,000 4,469E-04 6,72E-03 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 44 26 2,000 4,469E-04 6,678E-03 ! regulation of hormone biosynthetic process GO:0046885 10 6 1,000 4,903E-04 7,282E-03 ! male meiosis GO:0007140 7 6 1,000 4,903E-04 7,237E-03 ! embryonic hemopoiesis GO:0035162 14 6 1,000 4,903E-04 7,193E-03 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 1,000 4,903E-04 7,149E-03 ! negative regulation of gliogenesis GO:0014014 18 6 1,000 4,903E-04 7,106E-03 GO:0045686|negative regulation of glial cell differentiation, ! astrocyte development GO:0014002 15 6 1,000 4,903E-04 7,064E-03 ! enucleate erythrocyte differentiation GO:0043353 12 6 1,000 4,903E-04 7,022E-03 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 1,000 4,903E-04 6,98E-03 ! hair follicle maturation GO:0048820 7 6 1,000 4,903E-04 6,939E-03 ! Schwann cell development GO:0014044 15 6 1,000 4,903E-04 6,898E-03 ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 4,903E-04 6,858E-03 ! negative regulation of B cell activation GO:0050869 13 6 1,000 4,903E-04 6,819E-03 ! primary neural tube formation GO:0014020 51 27 2,000 5,006E-04 6,922E-03 ! positive regulation of cell motion GO:0051272 146 64 3,000 5,219E-04 7,176E-03 ! regulation of coagulation GO:0050818 46 29 2,000 6,201E-04 8,477E-03 ! negative regulation of cell growth GO:0030308 132 67 3,000 6,212E-04 8,444E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 6,838E-04 9,243E-03 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 6,838E-04 9,191E-03 ! mRNA stabilization GO:0048255 18 7 1,000 6,838E-04 9,14E-03 GO:0043489|RNA stabilization, ! adrenal gland development GO:0030325 17 7 1,000 6,838E-04 9,09E-03 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 1,000 6,838E-04 9,04E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 6,838E-04 8,99E-03 ! vesicle fusion GO:0006906 17 7 1,000 6,838E-04 8,941E-03 ! G1 DNA damage checkpoint GO:0031571 21 7 1,000 6,838E-04 8,893E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 1,000 6,838E-04 8,845E-03 ! respiratory chain complex IV assembly GO:0008535 14 7 1,000 6,838E-04 8,798E-03 ! oxygen homeostasis GO:0032364 12 7 1,000 6,838E-04 8,751E-03 ! transcription termination GO:0006353 13 7 1,000 6,838E-04 8,705E-03 ! coenzyme A metabolic process GO:0015936 12 7 1,000 6,838E-04 8,659E-03 ! regulation of B cell activation GO:0050864 50 30 2,000 6,861E-04 8,643E-03 ! cell cycle checkpoint GO:0000075 137 69 3,000 6,944E-04 8,702E-03 ! cholesterol homeostasis GO:0042632 53 31 2,000 7,564E-04 9,429E-03 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 43 31 2,000 7,564E-04 9,381E-03 ! regulation of MAPKKK cascade GO:0043408 142 71 3,000 7,735E-04 9,544E-03 ! cholesterol transport GO:0030301 56 32 2,000 8,311E-04 0,0102023 ! positive regulation of catabolic process GO:0009896 64 32 2,000 8,311E-04 0,01015051 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 9,083E-04 0,01103686 ! T-helper 1 type immune response GO:0042088 12 8 1,000 9,083E-04 0,01098139 ! hemoglobin metabolic process GO:0020027 13 8 1,000 9,083E-04 0,01092649 ! astrocyte differentiation GO:0048708 18 8 1,000 9,083E-04 0,01087213 ! ER overload response GO:0006983 12 8 1,000 9,083E-04 0,0108183 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 9,083E-04 0,01076501 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 9,083E-04 0,01071224 ! regulation of vascular permeability GO:0043114 12 8 1,000 9,083E-04 0,01065999 ! Schwann cell differentiation GO:0014037 19 8 1,000 9,083E-04 0,01060824 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 1,000 9,083E-04 0,01055699 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 1,000 9,083E-04 0,01050624 ! ATP catabolic process GO:0006200 11 8 1,000 9,083E-04 0,01045597 ! sterol transport GO:0015918 57 33 2,000 9,104E-04 0,01043009 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 2,000 9,942E-04 0,01133713 ! placenta development GO:0001890 53 34 2,000 9,942E-04 0,01128365 ! neural tube formation GO:0001841 67 35 2,000 1,083E-03 0,01223167 ! negative regulation of cell adhesion GO:0007162 81 35 2,000 1,083E-03 0,01217451 ! neutral lipid metabolic process GO:0006638 50 35 2,000 1,083E-03 0,01211789 GO:0006639|acylglycerol metabolic process, ! protein oligomerization GO:0051259 139 78 3,000 1,101E-03 0,01225922 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,163E-03 0,01289861 ! DNA synthesis during DNA repair GO:0000731 14 9 1,000 1,163E-03 0,01283945 ! induction of positive chemotaxis GO:0050930 15 9 1,000 1,163E-03 0,01278082 ! artery development GO:0060840 24 9 1,000 1,163E-03 0,01272272 GO:0048844|artery morphogenesis, ! regulation of glycolysis GO:0006110 21 9 1,000 1,163E-03 0,01266515 ! microtubule bundle formation GO:0001578 21 9 1,000 1,163E-03 0,0126081 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,163E-03 0,01255157 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 1,000 1,163E-03 0,01249553 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! protein targeting to ER GO:0045047 22 9 1,000 1,163E-03 0,01244 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 1,000 1,163E-03 0,01238495 ! positive regulation of erythrocyte differentiation GO:0045648 29 9 1,000 1,163E-03 0,01233039 ! regulation of macrophage differentiation GO:0045649 15 9 1,000 1,163E-03 0,01227631 ! branched chain family amino acid catabolic process GO:0009083 17 9 1,000 1,163E-03 0,0122227 ! regulation of telomere maintenance GO:0032204 14 9 1,000 1,163E-03 0,01216956 ! protein import into nucleus GO:0006606 158 80 3,000 1,209E-03 0,01259694 ! nuclear import GO:0051170 161 81 3,000 1,267E-03 0,01313538 ! glycerol ether metabolic process GO:0006662 53 37 2,000 1,275E-03 0,01316272 ! cellular response to insulin stimulus GO:0032869 82 37 2,000 1,275E-03 0,01310647 ! nucleus organization GO:0006997 67 38 2,000 1,378E-03 0,01410952 ! lipid homeostasis GO:0055088 67 38 2,000 1,378E-03 0,01404973 ! embryonic epithelial tube formation GO:0001838 72 38 2,000 1,378E-03 0,01399045 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 1,449E-03 0,01464483 ! SMAD protein nuclear translocation GO:0007184 20 10 1,000 1,449E-03 0,01458355 ! lung alveolus development GO:0048286 26 10 1,000 1,449E-03 0,01452279 ! negative regulation of striated muscle development GO:0045843 19 10 1,000 1,449E-03 0,01446253 ! glucan biosynthetic process GO:0009250 14 10 1,000 1,449E-03 0,01440277 GO:0005978|glycogen biosynthetic process, ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 1,000 1,449E-03 0,0143435 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 1,000 1,449E-03 0,01428471 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,449E-03 0,01422641 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 1,000 1,449E-03 0,01416858 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 1,000 1,449E-03 0,01411121 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 1,000 1,449E-03 0,01405431 ! regulation of DNA replication initiation GO:0030174 14 10 1,000 1,449E-03 0,01399787 ! positive regulation of leukocyte migration GO:0002687 25 10 1,000 1,449E-03 0,01394188 ! negative regulation of BMP signaling pathway GO:0030514 19 10 1,000 1,449E-03 0,01388633 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 1,449E-03 0,01383123 GO:0043470|regulation of carbohydrate catabolic process, ! localization within membrane GO:0051668 20 10 1,000 1,449E-03 0,01377656 ! mammary gland development GO:0030879 86 39 2,000 1,487E-03 0,01408225 ! organic ether metabolic process GO:0018904 55 39 2,000 1,487E-03 0,01402703 ! protein localization in nucleus GO:0034504 176 87 3,000 1,65E-03 0,01550509 ! gland development GO:0048732 206 88 3,000 1,721E-03 0,01610818 ! negative regulation of muscle development GO:0048635 20 11 1,000 1,764E-03 0,01644906 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,764E-03 0,01638555 ! blood vessel remodeling GO:0001974 29 11 1,000 1,764E-03 0,01632253 ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 1,764E-03 0,01625999 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 1,000 1,764E-03 0,01619793 ! purine ribonucleotide catabolic process GO:0009154 17 11 1,000 1,764E-03 0,01613634 ! regulation of leukocyte migration GO:0002685 26 11 1,000 1,764E-03 0,01607521 ! regulation of cell adhesion GO:0030155 212 89 3,000 1,794E-03 0,01628423 ! negative regulation of protein complex disassembly GO:0043242 101 42 2,000 1,844E-03 0,01667867 ! regulation of intracellular protein transport GO:0033157 80 42 2,000 1,844E-03 0,0166162 ! regulation of myeloid cell differentiation GO:0045637 98 42 2,000 1,844E-03 0,0165542 ! neural tube development GO:0021915 77 43 2,000 1,974E-03 0,01765488 ! regulation of membrane potential GO:0042391 164 93 3,000 2,107E-03 0,01877441 ! negative regulation of multicellular organismal process GO:0051241 166 93 3,000 2,107E-03 0,01870514 ! regulation of positive chemotaxis GO:0050926 19 12 1,000 2,109E-03 0,0186519 GO:0050927|positive regulation of positive chemotaxis, ! protein complex disassembly GO:0043241 27 12 1,000 2,109E-03 0,01858358 GO:0043624|cellular protein complex disassembly, ! drug transport GO:0015893 16 12 1,000 2,109E-03 0,01851575 ! histone acetylation GO:0016573 26 12 1,000 2,109E-03 0,01844842 ! autonomic nervous system development GO:0048483 24 12 1,000 2,109E-03 0,01838158 ! regulation of hormone metabolic process GO:0032350 26 12 1,000 2,109E-03 0,01831522 ! T cell homeostasis GO:0043029 25 12 1,000 2,109E-03 0,01824934 ! negative regulation of mast cell proliferation GO:0070667 23 12 1,000 2,109E-03 0,01818393 GO:0042130|negative regulation of T cell proliferation, ! regulation of actin filament polymerization GO:0030833 87 45 2,000 2,251E-03 0,01933854 ! regulation of JAK-STAT cascade GO:0046425 70 45 2,000 2,251E-03 0,01926972 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 2,000 2,397E-03 0,02045452 ! pigmentation GO:0043473 100 46 2,000 2,397E-03 0,02038224 ! response to insulin stimulus GO:0032868 95 46 2,000 2,397E-03 0,02031047 ! regulation of chemokine production GO:0032642 18 13 1,000 2,483E-03 0,02095794 ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 1,000 2,483E-03 0,02088466 ! organelle fusion GO:0048284 32 13 1,000 2,483E-03 0,02081189 ! ribonucleotide catabolic process GO:0009261 20 13 1,000 2,483E-03 0,02073962 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 2,483E-03 0,02066786 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! cotranslational protein targeting to membrane GO:0006613 24 13 1,000 2,483E-03 0,02059659 ! nucleoside triphosphate catabolic process GO:0009143 21 13 1,000 2,483E-03 0,02052581 ! positive regulation of Ras GTPase activity GO:0032320 35 13 1,000 2,483E-03 0,02045552 ! regulation of mRNA stability GO:0043488 31 13 1,000 2,483E-03 0,02038571 ! embryonic placenta development GO:0001892 23 13 1,000 2,483E-03 0,02031637 ! protein homooligomerization GO:0051260 76 47 2,000 2,55E-03 0,02079836 ! skeletal muscle tissue development GO:0007519 186 99 3,000 2,645E-03 0,021497 GO:0060538|skeletal muscle organ development, ! positive regulation of cell cycle GO:0045787 89 48 2,000 2,709E-03 0,02194278 ! morphogenesis of embryonic epithelium GO:0016331 91 48 2,000 2,709E-03 0,02186914 ! activation of caspase activity GO:0006919 84 48 2,000 2,709E-03 0,021796 ! regulation of mast cell proliferation GO:0070666 81 48 2,000 2,709E-03 0,02172335 ! regulation of protein complex disassembly GO:0043244 113 49 2,000 2,873E-03 0,02296616 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 2,885E-03 0,02298713 ! actin cytoskeleton reorganization GO:0031532 33 14 1,000 2,885E-03 0,02291126 ! negative regulation of protein import into nucleus GO:0042308 30 14 1,000 2,885E-03 0,0228359 ! regulation of erythrocyte differentiation GO:0045646 44 14 1,000 2,885E-03 0,02276103 ! regulation of RNA stability GO:0043487 32 14 1,000 2,885E-03 0,02268664 ! release of cytochrome c from mitochondria GO:0001836 30 14 1,000 2,885E-03 0,02261275 ! vesicle organization GO:0016050 107 51 2,000 3,22E-03 0,02515615 ! regulation of leukocyte proliferation GO:0070663 88 51 2,000 3,22E-03 0,02507474 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of cell shape GO:0008360 125 51 2,000 3,22E-03 0,02499385 ! epithelial tube morphogenesis GO:0060562 98 51 2,000 3,22E-03 0,02491348 ! negative regulation of bone remodeling GO:0046851 33 15 1,000 3,317E-03 0,02557627 ! G1/S transition checkpoint GO:0031575 40 15 1,000 3,317E-03 0,02549456 ! lymphocyte homeostasis GO:0002260 30 15 1,000 3,317E-03 0,02541337 ! regulation of angiogenesis GO:0045765 114 52 2,000 3,403E-03 0,02599332 ! regulation of muscle contraction GO:0006937 81 52 2,000 3,403E-03 0,02591106 ! regulation of translational initiation GO:0006446 82 53 2,000 3,592E-03 0,027264 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 2,000 3,592E-03 0,02717826 ! regulation of neuron apoptosis GO:0043523 100 53 2,000 3,592E-03 0,02709306 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 3,776E-03 0,02839141 ! embryonic forelimb morphogenesis GO:0035115 28 16 1,000 3,776E-03 0,02830296 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 1,000 3,776E-03 0,02821506 ! negative regulation of microtubule depolymerization GO:0007026 46 16 1,000 3,776E-03 0,02812771 GO:0031114|regulation of microtubule depolymerization, ! fructose metabolic process GO:0006000 25 16 1,000 3,776E-03 0,02804089 ! negative regulation of tissue remodeling GO:0034104 36 16 1,000 3,776E-03 0,02795461 ! negative regulation of leukocyte proliferation GO:0070664 31 16 1,000 3,776E-03 0,02786886 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 3,776E-03 0,02778364 ! negative regulation of cytoskeleton organization GO:0051494 124 54 2,000 3,787E-03 0,0277824 ! positive regulation of caspase activity GO:0043280 95 55 2,000 3,989E-03 0,02917284 GO:0010952|positive regulation of peptidase activity, ! regulation of actin filament length GO:0030832 105 56 2,000 4,197E-03 0,03060166 ! positive regulation of organelle organization GO:0010638 100 56 2,000 4,197E-03 0,03050921 ! heart looping GO:0001947 30 17 1,000 4,263E-03 0,03089657 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 1,000 4,263E-03 0,03080379 ! neural crest cell migration GO:0001755 37 17 1,000 4,263E-03 0,03071156 ! branched chain family amino acid metabolic process GO:0009081 33 17 1,000 4,263E-03 0,03061988 ! negative regulation of homeostatic process GO:0032845 33 17 1,000 4,263E-03 0,03052875 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 1,000 4,263E-03 0,03043816 ! gene silencing by RNA GO:0031047 36 17 1,000 4,263E-03 0,03034811 ! glial cell development GO:0021782 27 17 1,000 4,263E-03 0,03025859 ! regulation of bone remodeling GO:0046850 137 57 2,000 4,412E-03 0,03122007 ! regulation of intracellular transport GO:0032386 101 57 2,000 4,412E-03 0,03112852 ! regulation of tissue remodeling GO:0034103 140 58 2,000 4,633E-03 0,03259307 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 4,778E-03 0,0335167 ! protein amino acid ADP-ribosylation GO:0006471 33 18 1,000 4,778E-03 0,03341927 ! positive regulation of proteolysis GO:0045862 31 18 1,000 4,778E-03 0,0333224 ! regulation of BMP signaling pathway GO:0030510 32 18 1,000 4,778E-03 0,0332261 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 1,000 4,778E-03 0,03313034 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 1,000 4,778E-03 0,03303514 ! regulation of cellular component size GO:0032535 109 59 2,000 4,861E-03 0,03350917 ! DNA catabolic process GO:0006308 86 59 2,000 4,861E-03 0,03341343 ! positive regulation of angiogenesis GO:0045766 44 19 1,000 5,32E-03 0,03646769 ! lipid phosphorylation GO:0046834 35 19 1,000 5,32E-03 0,03636409 ! forelimb morphogenesis GO:0035136 32 19 1,000 5,32E-03 0,03626108 ! cerebral cortex development GO:0021987 36 19 1,000 5,32E-03 0,03615865 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 1,000 5,32E-03 0,03605679 ! visual learning GO:0008542 36 19 1,000 5,32E-03 0,03595551 ! purine nucleotide catabolic process GO:0006195 29 19 1,000 5,32E-03 0,03585479 ! estrogen receptor signaling pathway GO:0030520 38 19 1,000 5,32E-03 0,03575464 ! response to peptide hormone stimulus GO:0043434 122 61 2,000 5,336E-03 0,03576201 ! protein amino acid acetylation GO:0006473 39 20 1,000 5,889E-03 0,03935741 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 1,000 5,889E-03 0,03924839 ! regulation of carbohydrate metabolic process GO:0006109 38 20 1,000 5,889E-03 0,03913996 GO:0010675|regulation of cellular carbohydrate metabolic process, ! response to alkaloid GO:0043279 38 20 1,000 5,889E-03 0,03903214 ! camera-type eye morphogenesis GO:0048593 42 20 1,000 5,889E-03 0,03892491 ! negative regulation of T cell activation GO:0050868 40 20 1,000 5,889E-03 0,03881827 ! negative regulation of translation GO:0017148 29 20 1,000 5,889E-03 0,03871221 ! hindlimb morphogenesis GO:0035137 43 21 1,000 6,484E-03 0,04250945 ! cellular macromolecular complex disassembly GO:0034623 43 21 1,000 6,484E-03 0,04239393 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 1,000 6,484E-03 0,04227905 ! positive regulation of locomotion GO:0040017 39 21 1,000 6,484E-03 0,04216478 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 59 21 1,000 6,484E-03 0,04205113 ! negative regulation of intracellular transport GO:0032387 41 21 1,000 6,484E-03 0,04193809 ! lung development GO:0030324 144 67 2,000 6,926E-03 0,04467513 ! homeostasis of number of cells GO:0048872 114 67 2,000 6,926E-03 0,04455568 ! positive regulation of protein catabolic process GO:0045732 38 22 1,000 7,106E-03 0,0455901 ! regulation of chemotaxis GO:0050920 40 22 1,000 7,106E-03 0,04546885 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 1,000 7,106E-03 0,04534825 ! positive regulation of intracellular transport GO:0032388 37 22 1,000 7,106E-03 0,04522828 ! positive regulation of B cell activation GO:0050871 38 22 1,000 7,106E-03 0,04510894 ! visual behavior GO:0007632 42 23 1,000 7,753E-03 0,04908911 ! purine ribonucleoside metabolic process GO:0046128 34 23 1,000 7,753E-03 0,04896027 GO:0042278|purine nucleoside metabolic process, ! barbed-end actin filament capping GO:0051016 50 23 1,000 7,753E-03 0,0488321 GO:0051693|actin filament capping, ! respiratory tube development GO:0030323 150 70 2,000 7,815E-03 0,04909491 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 8,426E-03 0,05279408 ! vesicle docking GO:0048278 47 24 1,000 8,426E-03 0,05265696 ! spinal cord development GO:0021510 47 24 1,000 8,426E-03 0,05252054 ! regulation of behavior GO:0050795 43 24 1,000 8,426E-03 0,05238483 ! pallium development GO:0021543 49 24 1,000 8,426E-03 0,05224981 ! leukocyte homeostasis GO:0001776 44 24 1,000 8,426E-03 0,0521155 ! regulation of caspase activity GO:0043281 122 72 2,000 8,444E-03 0,05209114 ! respiratory system development GO:0060541 153 72 2,000 8,444E-03 0,05195792 ! learning or memory GO:0007611 147 73 2,000 8,769E-03 0,05382056 ! regulation of transcription factor activity GO:0051090 126 74 2,000 9,101E-03 0,05571813 GO:0090046|regulation of transcription regulator activity, ! transition metal ion transport GO:0000041 126 74 2,000 9,101E-03 0,05557672 ! regulation of actin cytoskeleton organization GO:0032956 149 74 2,000 9,101E-03 0,05543602 ! regulation of endopeptidase activity GO:0052548 125 74 2,000 9,101E-03 0,05529603 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 1,000 9,124E-03 0,05529655 ! myelination GO:0042552 45 25 1,000 9,124E-03 0,05515762 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 1,000 9,124E-03 0,05501938 ! osteoblast differentiation GO:0001649 60 25 1,000 9,124E-03 0,05488183 ! response to endoplasmic reticulum stress GO:0034976 43 25 1,000 9,124E-03 0,05474497 ! neural crest cell development GO:0014032 54 25 1,000 9,124E-03 0,05460878 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 73 25 1,000 9,124E-03 0,05447328 GO:0050768|negative regulation of neurogenesis, ! somitogenesis GO:0001756 43 25 1,000 9,124E-03 0,05433844 ! liver development GO:0001889 53 25 1,000 9,124E-03 0,05420427 ! phosphoinositide-mediated signaling GO:0048015 131 75 2,000 9,441E-03 0,05594662 ! defense response to bacterium GO:0042742 89 76 2,000 9,788E-03 0,05786004 ! regulation of catabolic process GO:0009894 161 76 2,000 9,788E-03 0,05771822 ! negative regulation of actin filament depolymerization GO:0030835 55 26 1,000 9,847E-03 0,05792793 ! negative regulation of actin filament polymerization GO:0030837 53 26 1,000 9,847E-03 0,05778665 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 1,000 9,847E-03 0,05764605 ! molting cycle process GO:0022404 50 26 1,000 9,847E-03 0,05750613 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 53 26 1,000 9,847E-03 0,05736689 ! regulation of transcription factor import into nucleus GO:0042990 54 26 1,000 9,847E-03 0,05722832 ! cellular response to oxidative stress GO:0034599 39 26 1,000 9,847E-03 0,05709042 ! group transfer coenzyme metabolic process GO:0006752 47 26 1,000 9,847E-03 0,05695318 ! regulation of actin filament-based process GO:0032970 152 77 2,000 0,01014191 0,0585166 ! negative regulation of organelle organization GO:0010639 161 78 2,000 0,01050356 0,06045828 ! regulation of fibroblast proliferation GO:0048145 52 27 1,000 0,010595 0,06083906 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 0,010595 0,06069421 ! iron ion transport GO:0006826 59 27 1,000 0,010595 0,06055004 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 1,000 0,010595 0,06040656 ! protein amino acid acylation GO:0043543 55 27 1,000 0,010595 0,06026375 ! regulation of chromosome organization GO:0033044 42 27 1,000 0,010595 0,06012162 ! negative regulation of protein polymerization GO:0032272 55 27 1,000 0,010595 0,05998016 ! negative regulation of lymphocyte activation GO:0051250 53 27 1,000 0,010595 0,05983936 ! regulation of actin filament depolymerization GO:0030834 58 28 1,000 0,01136705 0,06404947 ! dendrite development GO:0016358 59 28 1,000 0,01136705 0,06389983 ! ER-nuclear signaling pathway GO:0006984 48 28 1,000 0,01136705 0,06375087 ! cellular response to hormone stimulus GO:0032870 167 82 2,000 0,01202447 0,06728109 ! negative regulation of protein complex assembly GO:0031333 59 29 1,000 0,01216312 0,067899 ! cellular response to extracellular stimulus GO:0031668 48 29 1,000 0,01216312 0,06774183 ! negative regulation of neuron apoptosis GO:0043524 56 29 1,000 0,01216312 0,06758538 ! zinc ion transport GO:0006829 45 30 1,000 0,01298291 0,07197438 ! membrane docking GO:0022406 61 30 1,000 0,01298291 0,07180892 ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 0,01298291 0,07164422 ! ensheathment of neurons GO:0007272 57 30 1,000 0,01298291 0,07148027 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 56 30 1,000 0,01298291 0,07131708 ! eye morphogenesis GO:0048592 60 30 1,000 0,01298291 0,07115462 ! response to heat GO:0009408 50 30 1,000 0,01298291 0,07099291 ! nucleosome assembly GO:0006334 122 85 2,000 0,01324383 0,07225543 ! chromatin assembly GO:0031497 124 86 2,000 0,01366538 0,07438664 ! tube morphogenesis GO:0035239 176 86 2,000 0,01366538 0,07421872 ! collagen metabolic process GO:0032963 45 31 1,000 0,01382612 0,07492261 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 1,000 0,01382612 0,07475424 ! erythrocyte differentiation GO:0030218 55 31 1,000 0,01382612 0,07458663 ! negative regulation of transcription regulator activity GO:0090048 58 31 1,000 0,01382612 0,07441977 GO:0043433|negative regulation of transcription factor activity, ! regulation of protein transport GO:0051223 154 87 2,000 0,0140945 0,07569504 GO:0070201|regulation of establishment of protein localization, ! spindle organization GO:0007051 46 32 1,000 0,01469245 0,07873059 ! metanephros development GO:0001656 74 32 1,000 0,01469245 0,07855564 ! response to mechanical stimulus GO:0009612 57 32 1,000 0,01469245 0,07838146 ! regulation of protein import into nucleus GO:0042306 63 32 1,000 0,01469245 0,07820805 ! peripheral nervous system development GO:0007422 64 32 1,000 0,01469245 0,0780354 ! gene silencing GO:0016458 65 32 1,000 0,01469245 0,07786352 ! regulation of cell morphogenesis GO:0022604 215 89 2,000 0,01497557 0,07918948 ! ossification GO:0001503 188 90 2,000 0,01542753 0,08140052 ! protein-DNA complex assembly GO:0065004 130 90 2,000 0,01542753 0,0812224 ! DNA damage checkpoint GO:0000077 71 33 1,000 0,01558162 0,08185453 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,01558162 0,0816762 ! protein targeting to membrane GO:0006612 68 33 1,000 0,01558162 0,08149864 ! leukocyte chemotaxis GO:0030595 50 33 1,000 0,01558162 0,08132185 GO:0060326|cell chemotaxis, ! negative regulation of protein transport GO:0051224 69 33 1,000 0,01558162 0,08114583 ! bone development GO:0060348 189 91 2,000 0,01588713 0,08255819 ! nucleosome organization GO:0034728 138 92 2,000 0,01635439 0,08480314 ! glial cell differentiation GO:0010001 63 34 1,000 0,01649333 0,08533968 ! regulation of striated muscle tissue development GO:0016202 69 34 1,000 0,01649333 0,08515655 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 1,000 0,01649333 0,0849742 ! regulation of muscle development GO:0048634 70 35 1,000 0,0174273 0,08959419 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 0,0174273 0,08940315 ! telencephalon development GO:0021537 68 35 1,000 0,0174273 0,08921293 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,0174273 0,08902352 ! regulation of Rho protein signal transduction GO:0035023 213 95 2,000 0,01780217 0,09074581 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 2,000 0,01830014 0,09308695 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! DNA integrity checkpoint GO:0031570 75 36 1,000 0,01838324 0,09331239 ! regulation of proteolysis GO:0030162 72 36 1,000 0,01838324 0,09311594 ! aerobic respiration GO:0009060 55 36 1,000 0,01838324 0,09292032 ! embryonic organ development GO:0048568 57 36 1,000 0,01838324 0,09272552 ! negative regulation of cell activation GO:0050866 65 36 1,000 0,01838324 0,09253153 ! regulation of DNA metabolic process GO:0051052 178 97 2,000 0,0188058 0,09446086 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 2,000 0,0188058 0,09426407 ! regulation of protein localization GO:0032880 176 97 2,000 0,0188058 0,09406809 ! response to virus GO:0009615 160 98 2,000 0,01931917 0,09643551 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 2,000 0,01931917 0,09623585 ! negative regulation of DNA binding GO:0043392 68 37 1,000 0,01936087 0,09624432 ! regulation of protein stability GO:0031647 73 37 1,000 0,01936087 0,09604588 ! mitotic cell cycle checkpoint GO:0007093 76 38 1,000 0,02035991 0,10079413 ! carbohydrate homeostasis GO:0033500 53 38 1,000 0,02035991 0,10058716 GO:0042593|glucose homeostasis, ! nucleotide catabolic process GO:0009166 61 38 1,000 0,02035991 0,10038104 ! erythrocyte homeostasis GO:0034101 64 38 1,000 0,02035991 0,10017576 ! positive regulation of leukocyte proliferation GO:0070665 62 38 1,000 0,02035991 0,09997132 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! learning GO:0007612 77 39 1,000 0,02138009 0,10476678 ! ear morphogenesis GO:0042471 60 39 1,000 0,02138009 0,10455384 ! segmentation GO:0035282 67 39 1,000 0,02138009 0,10434177 ! regulation of action potential in neuron GO:0019228 73 39 1,000 0,02138009 0,10413055 ! negative regulation of binding GO:0051100 72 40 1,000 0,02242112 0,10898025 ! multicellular organismal metabolic process GO:0044236 57 40 1,000 0,02242112 0,10876053 ! cytokinesis GO:0000910 72 40 1,000 0,02242112 0,1085417 ! gliogenesis GO:0042063 88 41 1,000 0,02348275 0,11345278 ! regulation of T cell proliferation GO:0042129 71 41 1,000 0,02348275 0,11322542 ! T cell differentiation GO:0030217 81 41 1,000 0,02348275 0,11299897 ! regulation of T cell differentiation GO:0045580 70 41 1,000 0,02348275 0,11277343 ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,02456469 0,11773433 GO:0090047|positive regulation of transcription regulator activity, ! neuron migration GO:0001764 79 42 1,000 0,02456469 0,11750027 ! glucose transport GO:0015758 65 43 1,000 0,02566668 0,12252782 ! striated muscle cell differentiation GO:0051146 82 43 1,000 0,02566668 0,1222852 ! positive regulation of response to external stimulus GO:0032103 77 43 1,000 0,02566668 0,12204352 ! hexose transport GO:0008645 67 44 1,000 0,02678845 0,12712626 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 1,000 0,02678845 0,12687602 ! developmental growth GO:0048589 82 44 1,000 0,02678845 0,12662675 ! glycolysis GO:0006096 65 45 1,000 0,02792975 0,13176271 ! leukocyte migration GO:0050900 68 45 1,000 0,02792975 0,13150485 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,02792975 0,13124801 ! polysaccharide biosynthetic process GO:0000271 70 45 1,000 0,02792975 0,13099216 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,02855735 0,13367505 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,02855735 0,13341548 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02855735 0,13315692 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,02855735 0,13289937 ! neuron fate determination GO:0048664 7 5 0,000 0,02855735 0,13264281 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02855735 0,13238723 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,02855735 0,13213264 ! polyol transport GO:0015791 12 5 0,000 0,02855735 0,13187903 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,02855735 0,13162639 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02855735 0,13137471 ! response to superoxide GO:0000303 10 5 0,000 0,02855735 0,13112399 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,02855735 0,13087423 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,02855735 0,13062542 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02855735 0,13037756 ! female meiosis GO:0007143 7 5 0,000 0,02855735 0,13013063 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02855735 0,12988464 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02855735 0,12963957 ! cobalt ion transport GO:0006824 11 5 0,000 0,02855735 0,12939543 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,02855735 0,12915221 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,02855735 0,12890989 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,02855735 0,12866849 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02855735 0,12842799 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02855735 0,12818838 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,02855735 0,12794967 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,02855735 0,12771185 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02855735 0,1274749 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,02855735 0,12723884 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,02855735 0,12700365 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02855735 0,12676932 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02855735 0,12653586 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02855735 0,12630326 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 0,000 0,02855735 0,12607151 ! negative chemotaxis GO:0050919 14 5 0,000 0,02855735 0,12584061 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02855735 0,12561055 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,02855735 0,12538134 ! behavioral response to pain GO:0048266 9 5 0,000 0,02855735 0,12515296 ! clathrin coat assembly GO:0048268 14 5 0,000 0,02855735 0,12492541 ! Notch receptor processing GO:0007220 8 5 0,000 0,02855735 0,12469868 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02855735 0,12447278 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02855735 0,12424769 ! micturition GO:0060073 9 5 0,000 0,02855735 0,12402342 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02855735 0,12379995 ! copulation GO:0007620 9 5 0,000 0,02855735 0,12357729 ! glial cell fate commitment GO:0021781 13 5 0,000 0,02855735 0,12335543 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,02855735 0,12313436 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02855735 0,12291408 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02855735 0,1226946 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02855735 0,12247589 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,02855735 0,12225796 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02855735 0,12204081 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02855735 0,12182442 ! grooming behavior GO:0007625 6 5 0,000 0,02855735 0,1216088 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,02855735 0,12139395 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02855735 0,12117985 ! response to protozoan GO:0001562 10 5 0,000 0,02855735 0,1209665 ! lymph vessel development GO:0001945 10 5 0,000 0,02855735 0,12075391 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,02855735 0,12054206 ! endochondral ossification GO:0001958 16 5 0,000 0,02855735 0,12033095 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02855735 0,12012058 ! parathyroid gland development GO:0060017 13 5 0,000 0,02855735 0,11991095 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02855735 0,11970204 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02855735 0,11949387 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 0,000 0,02855735 0,11928641 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,02855735 0,11907968 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,02855735 0,11887366 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,02855735 0,11866835 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,02855735 0,11846375 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,02855735 0,11825985 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02855735 0,11805666 ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02855735 0,11785416 ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,02855735 0,11765235 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,02855735 0,11745124 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02855735 0,11725081 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,02855735 0,11705106 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02855735 0,116852 ! histidine catabolic process GO:0006548 6 5 0,000 0,02855735 0,1166536 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02855735 0,11645589 ! valine metabolic process GO:0006573 10 5 0,000 0,02855735 0,11625884 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,02855735 0,11606245 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02855735 0,11586673 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,02855735 0,11567167 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,02855735 0,11547727 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02855735 0,11528351 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,02855735 0,11509041 ! polyol catabolic process GO:0046174 7 5 0,000 0,02855735 0,11489795 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02855735 0,11470613 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02855735 0,11451496 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02855735 0,11432441 ! muscle cell migration GO:0014812 8 5 0,000 0,02855735 0,11413451 ! mitochondrial fission GO:0000266 8 5 0,000 0,02855735 0,11394523 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,02855735 0,11375658 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,02855735 0,11356855 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,02855735 0,11338114 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,02855735 0,11319435 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02855735 0,11300818 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02855735 0,11282262 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02855735 0,11263766 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02855735 0,11245331 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02855735 0,11226956 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02855735 0,11208642 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,02855735 0,11190387 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02855735 0,11172191 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,02855735 0,11154054 ! forebrain neuron development GO:0021884 13 5 0,000 0,02855735 0,11135976 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02855735 0,11117957 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02855735 0,11099996 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02855735 0,11082092 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02855735 0,11064247 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02855735 0,11046459 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,02855735 0,11028728 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,02855735 0,11011053 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,02855735 0,10993436 ! basic amino acid transport GO:0015802 11 5 0,000 0,02855735 0,10975874 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,02855735 0,10958369 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,02855735 0,10940919 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02855735 0,10923525 ! depyrimidination GO:0045008 10 5 0,000 0,02855735 0,10906186 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02855735 0,10888902 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02855735 0,10871673 ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02855735 0,10854498 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,02855735 0,10837377 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 7 5 0,000 0,02855735 0,10820311 ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,02855735 0,10803298 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02855735 0,10786338 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02855735 0,10769432 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,02855735 0,10752578 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,02855735 0,10735777 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02855735 0,10719029 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02855735 0,10702332 ! response to arsenic GO:0046685 10 5 0,000 0,02855735 0,10685688 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,02855735 0,10669095 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02855735 0,10652554 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,02855735 0,10636064 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,02855735 0,10619625 ! response to cadmium ion GO:0046686 7 5 0,000 0,02855735 0,10603237 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,02855735 0,10586899 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,02855735 0,10570611 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02855735 0,10554374 ! decidualization GO:0046697 11 5 0,000 0,02855735 0,10538186 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,02855735 0,10522048 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,02855735 0,10505959 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02855735 0,1048992 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02855735 0,10473929 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,02855735 0,10457987 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02855735 0,10442093 ! neural tube patterning GO:0021532 7 5 0,000 0,02855735 0,10426248 ! embryonic cleavage GO:0040016 6 5 0,000 0,02855735 0,1041045 ! peroxisome fission GO:0016559 5 5 0,000 0,02855735 0,10394701 ! histone demethylation GO:0016577 10 5 0,000 0,02855735 0,10378999 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,02855735 0,10363344 ! mitotic recombination GO:0006312 9 5 0,000 0,02855735 0,10347737 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02855735 0,10332176 ! metaphase plate congression GO:0051310 7 5 0,000 0,02855735 0,10316663 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02855735 0,10301195 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02855735 0,10285774 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,02855735 0,102704 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,02855735 0,10255071 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,02855735 0,10239787 ! muscle cell proliferation GO:0033002 11 5 0,000 0,02855735 0,1022455 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02855735 0,10209357 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,02855735 0,1019421 ! plasminogen activation GO:0031639 5 5 0,000 0,02855735 0,10179107 ! B cell homeostasis GO:0001782 13 5 0,000 0,02855735 0,10164049 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,02855735 0,10149036 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02855735 0,10134067 ! metaphase GO:0051323 8 5 0,000 0,02855735 0,10119142 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,02855735 0,10104261 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02855735 0,10089423 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02855735 0,1007463 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02855735 0,10059879 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02855735 0,10045172 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02855735 0,10030507 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,02855735 0,10015885 ! response to redox state GO:0051775 5 5 0,000 0,02855735 0,10001306 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,02855735 0,09986769 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,02855735 0,09972275 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,02855735 0,09957822 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02855735 0,09943411 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,02855735 0,09929042 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02855735 0,09914715 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,02855735 0,09900428 ! striatum development GO:0021756 9 5 0,000 0,02855735 0,09886183 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,02855735 0,09871979 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,02855735 0,09857815 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02855735 0,09843692 ! glial cell migration GO:0008347 11 5 0,000 0,02855735 0,0982961 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02855735 0,09815568 ! regulation of mitochondrial depolarization GO:0051900 13 5 0,000 0,02855735 0,09801565 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02855735 0,09787603 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02855735 0,0977368 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02855735 0,09759797 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02855735 0,09745954 ! neuroprotection GO:0043526 6 5 0,000 0,02855735 0,09732149 ! neural plate development GO:0001840 8 5 0,000 0,02855735 0,09718384 ! regulation of sensory perception GO:0051931 7 5 0,000 0,02855735 0,09704657 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02855735 0,09690969 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02855735 0,0967732 ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,02855735 0,09663709 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,02855735 0,09650137 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02855735 0,09636602 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02855735 0,09623106 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02855735 0,09609647 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02855735 0,09596225 ! spindle assembly GO:0051225 6 5 0,000 0,02855735 0,09582841 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,02855735 0,09569495 GO:0016226|iron-sulfur cluster assembly, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02855735 0,09556185 ! drug metabolic process GO:0017144 6 5 0,000 0,02855735 0,09542913 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02855735 0,09529677 ! organ regeneration GO:0031100 7 5 0,000 0,02855735 0,09516478 ! carnitine metabolic process GO:0009437 7 5 0,000 0,02855735 0,09503316 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,02855735 0,0949019 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02855735 0,094771 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 1,000 0,02909031 0,09640673 ! regulation of gene-specific transcription GO:0032583 96 46 1,000 0,02909031 0,09627413 ! negative regulation of cell migration GO:0030336 115 46 1,000 0,02909031 0,09614188 ! positive regulation of protein transport GO:0051222 72 46 1,000 0,02909031 0,09601 ! vascular process in circulatory system GO:0003018 80 47 1,000 0,03026988 0,0997662 ! positive regulation of cyclase activity GO:0031281 103 47 1,000 0,03026988 0,09962972 ! positive regulation of lyase activity GO:0051349 104 48 1,000 0,03146819 0,10343233 ! regulation of lymphocyte differentiation GO:0045619 81 48 1,000 0,03146819 0,10329122 ! regulation of action potential GO:0001508 95 49 1,000 0,032685 0,10713912 ! response to temperature stimulus GO:0009266 76 49 1,000 0,032685 0,10699335 ! endocrine system development GO:0035270 104 49 1,000 0,032685 0,10684798 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,032685 0,106703 ! histone modification GO:0016570 91 50 1,000 0,03392006 0,1105849 ! negative regulation of immune system process GO:0002683 95 50 1,000 0,03392006 0,11043526 ! positive regulation of cytokine production GO:0001819 86 50 1,000 0,03392006 0,11028602 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,03417076 0,1109512 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,03417076 0,11080167 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,03417076 0,11065254 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03417076 0,11050382 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,03417076 0,11035549 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,03417076 0,11020756 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,03417076 0,11006003 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,03417076 0,10991289 ! sleep GO:0030431 13 6 0,000 0,03417076 0,10976614 ! response to oxygen radical GO:0000305 11 6 0,000 0,03417076 0,10961979 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,03417076 0,10947382 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,03417076 0,10932824 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,03417076 0,10918305 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,03417076 0,10903825 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,03417076 0,10889383 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,03417076 0,10874979 ! forebrain regionalization GO:0021871 8 6 0,000 0,03417076 0,10860613 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,03417076 0,10846285 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,03417076 0,10831995 ! response to zinc ion GO:0010043 9 6 0,000 0,03417076 0,10817742 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,03417076 0,10803527 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,03417076 0,10789349 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,03417076 0,10775208 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,03417076 0,10761105 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,03417076 0,10747038 ! malate metabolic process GO:0006108 11 6 0,000 0,03417076 0,10733008 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,03417076 0,10719014 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,03417076 0,10705057 ! protein refolding GO:0042026 15 6 0,000 0,03417076 0,10691136 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,03417076 0,10677252 ! opsonization GO:0008228 8 6 0,000 0,03417076 0,10663403 ! mating behavior GO:0007617 7 6 0,000 0,03417076 0,10649591 ! neuron remodeling GO:0016322 15 6 0,000 0,03417076 0,10635814 ! erythrocyte maturation GO:0043249 7 6 0,000 0,03417076 0,10622072 ! equilibrioception GO:0050957 14 6 0,000 0,03417076 0,10608366 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,03417076 0,10594696 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,03417076 0,1058106 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03417076 0,1056746 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,03417076 0,10553895 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,03417076 0,10540364 ! response to interferon-gamma GO:0034341 15 6 0,000 0,03417076 0,10526868 ! toxin metabolic process GO:0009404 11 6 0,000 0,03417076 0,10513407 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,03417076 0,10499979 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03417076 0,10486587 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,03417076 0,10473228 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,03417076 0,10459903 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,03417076 0,10446612 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,03417076 0,10433355 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,03417076 0,10420132 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,03417076 0,10406942 ! thymic T cell selection GO:0045061 12 6 0,000 0,03417076 0,10393785 ! protein lipoylation GO:0009249 10 6 0,000 0,03417076 0,10380662 ! cysteine metabolic process GO:0006534 10 6 0,000 0,03417076 0,10367571 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03417076 0,10354514 ! glutamate catabolic process GO:0006538 10 6 0,000 0,03417076 0,10341489 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,03417076 0,10328497 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,03417076 0,10315538 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,03417076 0,10302611 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,03417076 0,10289717 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,03417076 0,10276855 ! hyperosmotic response GO:0006972 9 6 0,000 0,03417076 0,10264025 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,03417076 0,10251227 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,03417076 0,10238461 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,03417076 0,10225726 ! urea metabolic process GO:0019627 7 6 0,000 0,03417076 0,10213024 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,03417076 0,10200352 ! neutrophil activation GO:0042119 8 6 0,000 0,03417076 0,10187712 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,03417076 0,10175104 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,03417076 0,10162526 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,03417076 0,1014998 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03417076 0,10137465 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,03417076 0,1012498 ! neuron apoptosis GO:0051402 9 6 0,000 0,03417076 0,10112526 ! nucleoside salvage GO:0043174 9 6 0,000 0,03417076 0,10100103 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,03417076 0,1008771 ! T cell mediated immunity GO:0002456 16 6 0,000 0,03417076 0,10075348 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,03417076 0,10063016 GO:0010543|regulation of platelet activation, ! male sex determination GO:0030238 15 6 0,000 0,03417076 0,10050714 ! carnitine transport GO:0015879 10 6 0,000 0,03417076 0,10038442 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,03417076 0,100262 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03417076 0,10013988 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,03417076 0,10001805 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,03417076 0,09989652 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,03417076 0,09977529 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,03417076 0,09965435 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,03417076 0,0995337 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,03417076 0,09941335 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,03417076 0,09929328 ! establishment of spindle localization GO:0051293 12 6 0,000 0,03417076 0,09917351 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,03417076 0,09905402 ! monocyte differentiation GO:0030224 12 6 0,000 0,03417076 0,09893482 ! neural nucleus development GO:0048857 14 6 0,000 0,03417076 0,09881591 ! response to UV-C GO:0010225 11 6 0,000 0,03417076 0,09869729 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,03417076 0,09857894 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,03417076 0,09846089 ! interaction with symbiont GO:0051702 13 6 0,000 0,03417076 0,09834311 ! regulation of dendrite development GO:0050773 16 6 0,000 0,03417076 0,09822561 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03417076 0,0981084 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,03417076 0,09799147 ! response to copper ion GO:0046688 10 6 0,000 0,03417076 0,09787481 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,03417076 0,09775843 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03417076 0,09764233 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03417076 0,0975265 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,03417076 0,09741095 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,03417076 0,09729567 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,03417076 0,09718066 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,03417076 0,09706593 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,03417076 0,09695146 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03417076 0,09683727 ! regulation of myeloid cell apoptosis GO:0033032 13 6 0,000 0,03417076 0,09672334 ! subpallium development GO:0021544 10 6 0,000 0,03417076 0,09660968 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,03417076 0,09649629 ! histone ubiquitination GO:0016574 8 6 0,000 0,03417076 0,09638316 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,03417076 0,0962703 ! maintenance of organ identity GO:0048496 9 6 0,000 0,03417076 0,09615771 ! G2 phase GO:0051319 16 6 0,000 0,03417076 0,09604537 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,03417076 0,0959333 ! establishment of planar polarity GO:0001736 7 6 0,000 0,03417076 0,09582149 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,03417076 0,09570994 ! membrane to membrane docking GO:0022614 14 6 0,000 0,03417076 0,09559865 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,03417076 0,09548762 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,03417076 0,09537684 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,03417076 0,09526633 ! receptor internalization GO:0031623 10 6 0,000 0,03417076 0,09515606 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,03417076 0,09504606 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,03417076 0,0949363 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03417076 0,0948268 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,03417076 0,09471756 ! protein deubiquitination GO:0016579 14 6 0,000 0,03417076 0,09460856 ! protein destabilization GO:0031648 9 6 0,000 0,03417076 0,09449982 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,03417076 0,09439132 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,03417076 0,09428307 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03417076 0,09417507 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,03417076 0,09406732 ! progesterone metabolic process GO:0042448 10 6 0,000 0,03417076 0,09395982 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,03417076 0,09385256 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,03417076 0,09374554 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,03417076 0,09363877 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,03417076 0,09353224 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,03417076 0,09342595 ! determination of adult lifespan GO:0008340 15 6 0,000 0,03417076 0,09331991 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,03417076 0,0932141 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,03417076 0,09310854 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,03417076 0,09300321 ! catecholamine transport GO:0051937 9 6 0,000 0,03417076 0,09289812 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,03417076 0,09279327 ! sensory cilium assembly GO:0035058 10 6 0,000 0,03417076 0,09268866 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03417076 0,09258428 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,03417076 0,09248013 ! maternal placenta development GO:0001893 12 6 0,000 0,03417076 0,09237622 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,03417076 0,09227255 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,03417076 0,0921691 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,03417076 0,09206589 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03417076 0,09196291 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,03417076 0,09186016 ! membrane fusion GO:0006944 110 52 1,000 0,03644391 0,09786165 ! positive regulation of growth GO:0045927 90 52 1,000 0,03644391 0,09775255 ! covalent chromatin modification GO:0016569 101 52 1,000 0,03644391 0,09764369 ! cartilage development GO:0051216 90 52 1,000 0,03644391 0,09753508 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,03903778 0,10436099 GO:0010863|positive regulation of phospholipase C activity, ! heterocycle catabolic process GO:0046700 85 54 1,000 0,03903778 0,10424516 ! tRNA transcription GO:0009304 14 7 0,000 0,03975192 0,10603449 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,03975192 0,10591706 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,03975192 0,1057999 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03975192 0,10568299 ! regulation of helicase activity GO:0051095 15 7 0,000 0,03975192 0,10556635 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,03975192 0,10544995 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,03975192 0,10533382 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03975192 0,10521794 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,03975192 0,10510232 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03975192 0,10498695 ! prostate gland development GO:0030850 13 7 0,000 0,03975192 0,10487183 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,03975192 0,10475696 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03975192 0,10464235 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03975192 0,10452799 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,03975192 0,10441387 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03975192 0,10430001 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,03975192 0,10418639 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,03975192 0,10407302 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,03975192 0,1039599 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03975192 0,10384702 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,03975192 0,10373439 ! glycolipid transport GO:0046836 10 7 0,000 0,03975192 0,103622 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03975192 0,10350986 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,03975192 0,10339796 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,03975192 0,10328629 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03975192 0,10317487 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,03975192 0,10306369 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,03975192 0,10295275 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,03975192 0,10284205 ! pericardium development GO:0060039 14 7 0,000 0,03975192 0,10273159 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,03975192 0,10262136 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,03975192 0,10251137 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,03975192 0,10240162 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03975192 0,10229209 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03975192 0,10218281 ! lipoprotein transport GO:0042953 14 7 0,000 0,03975192 0,10207376 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03975192 0,10196493 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03975192 0,10185635 ! rhythmic behavior GO:0007622 15 7 0,000 0,03975192 0,10174799 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,03975192 0,10163986 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,03975192 0,10153196 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,03975192 0,10142429 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03975192 0,10131685 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,03975192 0,10120964 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03975192 0,10110265 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,03975192 0,10099589 ! mechanosensory behavior GO:0007638 14 7 0,000 0,03975192 0,10088936 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,03975192 0,10078304 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03975192 0,10067696 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,03975192 0,10057109 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03975192 0,10046545 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03975192 0,10036003 ! spinal cord patterning GO:0021511 13 7 0,000 0,03975192 0,10025483 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,03975192 0,10014985 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03975192 0,10004509 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,03975192 0,09994055 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,03975192 0,09983623 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,03975192 0,09973213 ! ovulation GO:0030728 9 7 0,000 0,03975192 0,09962824 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,03975192 0,09952457 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,03975192 0,09942111 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,03975192 0,09931787 ! microtubule nucleation GO:0007020 20 7 0,000 0,03975192 0,09921484 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03975192 0,09911203 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03975192 0,09900943 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,03975192 0,09890704 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,03975192 0,09880486 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,03975192 0,0987029 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03975192 0,09860114 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03975192 0,0984996 ! galactose metabolic process GO:0006012 13 7 0,000 0,03975192 0,09839826 ! response to dietary excess GO:0002021 8 7 0,000 0,03975192 0,09829713 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03975192 0,09819621 ! intracellular pH reduction GO:0051452 11 7 0,000 0,03975192 0,0980955 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03975192 0,09799499 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,03975192 0,09789469 ! organ growth GO:0035265 15 7 0,000 0,03975192 0,09779459 ! purine salvage GO:0043101 10 7 0,000 0,03975192 0,0976947 ! nucleoside transport GO:0015858 8 7 0,000 0,03975192 0,09759501 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,03975192 0,09749552 ! parturition GO:0007567 14 7 0,000 0,03975192 0,09739624 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,03975192 0,09729716 ! rRNA modification GO:0000154 14 7 0,000 0,03975192 0,09719828 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,03975192 0,0970996 ! spindle checkpoint GO:0031577 15 7 0,000 0,03975192 0,09700112 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,03975192 0,09690285 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,03975192 0,09680477 ! macrophage differentiation GO:0030225 11 7 0,000 0,03975192 0,09670688 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03975192 0,0966092 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,03975192 0,09651171 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,03975192 0,09641442 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03975192 0,09631733 ! fibrinolysis GO:0042730 10 7 0,000 0,03975192 0,09622043 ! eating behavior GO:0042755 7 7 0,000 0,03975192 0,09612373 ! B cell lineage commitment GO:0002326 21 7 0,000 0,03975192 0,09602722 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03975192 0,0959309 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,03975192 0,09583478 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,03975192 0,09573885 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,03975192 0,09564311 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,03975192 0,09554756 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,03975192 0,0954522 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,03975192 0,09535704 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,03975192 0,09526206 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,03975192 0,09516727 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03975192 0,09507267 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,03975192 0,09497826 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03975192 0,09488404 ! regulation of meiosis GO:0040020 12 7 0,000 0,03975192 0,09479 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,03975192 0,09469615 ! T cell lineage commitment GO:0002360 16 7 0,000 0,03975192 0,09460248 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,03975192 0,094509 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03975192 0,0944157 ! response to tumor cell GO:0002347 13 7 0,000 0,03975192 0,09432259 ! regulation of respiratory burst GO:0060263 11 7 0,000 0,03975192 0,09422966 ! anaphase GO:0051322 17 7 0,000 0,03975192 0,09413692 GO:0000090|mitotic anaphase, ! axonal fasciculation GO:0007413 18 7 0,000 0,03975192 0,09404435 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,03975192 0,09395197 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,03975192 0,09385977 ! peptidyl-threonine modification GO:0018210 25 7 0,000 0,03975192 0,09376775 ! diuresis GO:0030146 12 7 0,000 0,03975192 0,09367591 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03975192 0,09358426 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03975192 0,09349277 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03975192 0,09340147 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,03975192 0,09331035 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,03975192 0,0932194 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03975192 0,09312864 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03975192 0,09303804 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03975192 0,09294763 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,03975192 0,09285739 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,03975192 0,09276732 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,03975192 0,09267743 GO:0046479|glycosphingolipid catabolic process, ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,03975192 0,09258771 ! lymph node development GO:0048535 10 7 0,000 0,03975192 0,09249817 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,03975192 0,0924088 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03975192 0,0923196 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,03975192 0,09223058 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,03975192 0,09214172 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,03975192 0,09205304 ! adult feeding behavior GO:0008343 9 7 0,000 0,03975192 0,09196453 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,03975192 0,09187619 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,03975192 0,09178801 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03975192 0,09170001 ! muscle adaptation GO:0043500 14 7 0,000 0,03975192 0,09161217 ! embryonic heart tube development GO:0035050 10 7 0,000 0,03975192 0,09152451 ! retina homeostasis GO:0001895 12 7 0,000 0,03975192 0,09143701 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,03975192 0,09134967 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,03975192 0,09126251 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,03975192 0,09117551 ! protein prenylation GO:0018342 18 7 0,000 0,03975192 0,09108867 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03975192 0,09100201 ! glucose catabolic process GO:0006007 82 55 1,000 0,04036037 0,09230708 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,04036037 0,09221942 ! regulation of protein catabolic process GO:0042176 116 55 1,000 0,04036037 0,09213192 ! aging GO:0007568 103 55 1,000 0,04036037 0,09204459 ! heart morphogenesis GO:0003007 97 55 1,000 0,04036037 0,09195743 ! regulation of multicellular organism growth GO:0040014 85 55 1,000 0,04036037 0,09187043 ! negative regulation of cell motion GO:0051271 134 55 1,000 0,04036037 0,0917836 ! regulation of DNA replication GO:0006275 101 56 1,000 0,04169974 0,09473993 ! lipid modification GO:0030258 97 57 1,000 0,04305567 0,09772824 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,04305567 0,09763613 ! regulation of endocytosis GO:0030100 91 58 1,000 0,04442791 0,10065306 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,04442791 0,10055837 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,04530101 0,10243818 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,04530101 0,10234199 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 0,000 0,04530101 0,10224599 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,04530101 0,10215016 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,04530101 0,10205452 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04530101 0,10195905 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04530101 0,10186376 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,04530101 0,10176865 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,04530101 0,10167372 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,04530101 0,10157896 ! meiotic prophase I GO:0007128 13 8 0,000 0,04530101 0,10148438 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04530101 0,10138998 ! oligopeptide transport GO:0006857 15 8 0,000 0,04530101 0,10129575 ! signal peptide processing GO:0006465 12 8 0,000 0,04530101 0,10120169 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,04530101 0,10110781 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,04530101 0,10101411 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04530101 0,10092058 ! succinate metabolic process GO:0006105 14 8 0,000 0,04530101 0,10082722 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04530101 0,10073403 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,04530101 0,10064102 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,04530101 0,10054818 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04530101 0,10045551 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04530101 0,10036301 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,04530101 0,10027068 ! reflex GO:0060004 16 8 0,000 0,04530101 0,10017852 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,04530101 0,10008652 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,04530101 0,0999947 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04530101 0,09990305 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,04530101 0,09981156 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,04530101 0,09972024 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04530101 0,09962909 ! pigment granule organization GO:0048753 16 8 0,000 0,04530101 0,0995381 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04530101 0,09944729 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,04530101 0,09935663 ! histidine metabolic process GO:0006547 16 8 0,000 0,04530101 0,09926614 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04530101 0,09917582 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,04530101 0,09908566 ! glycine catabolic process GO:0006546 13 8 0,000 0,04530101 0,09899566 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,04530101 0,09890583 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,04530101 0,09881616 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,04530101 0,09872665 ! regulation of pigmentation during development GO:0048070 24 8 0,000 0,04530101 0,09863731 ! melanin metabolic process GO:0006582 15 8 0,000 0,04530101 0,09854812 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,04530101 0,0984591 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04530101 0,09837024 ! macrophage activation GO:0042116 12 8 0,000 0,04530101 0,09828154 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04530101 0,098193 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,04530101 0,09810461 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04530101 0,09801639 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,04530101 0,09792832 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,04530101 0,09784042 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,04530101 0,09775267 ! osteoblast development GO:0002076 16 8 0,000 0,04530101 0,09766508 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,04530101 0,09757764 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,04530101 0,09749036 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,04530101 0,09740324 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,04530101 0,09731627 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04530101 0,09722946 ! response to UV-B GO:0010224 16 8 0,000 0,04530101 0,0971428 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,04530101 0,0970563 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04530101 0,09696995 ! intermediate filament organization GO:0045109 12 8 0,000 0,04530101 0,09688376 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,04530101 0,09679771 ! cellular extravasation GO:0045123 12 8 0,000 0,04530101 0,09671182 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,04530101 0,09662609 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,04530101 0,0965405 ! response to antibiotic GO:0046677 11 8 0,000 0,04530101 0,09645507 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,04530101 0,09636978 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,04530101 0,09628465 ! DNA topological change GO:0006265 12 8 0,000 0,04530101 0,09619967 ! response to tropane GO:0014073 15 8 0,000 0,04530101 0,09611484 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,04530101 0,09603015 ! melanosome transport GO:0032402 13 8 0,000 0,04530101 0,09594562 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,04530101 0,09586124 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04530101 0,095777 ! mast cell activation GO:0045576 14 8 0,000 0,04530101 0,09569291 ! multicellular organismal aging GO:0010259 18 8 0,000 0,04530101 0,09560897 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,04530101 0,09552517 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,04530101 0,09544153 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,04530101 0,09535803 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04530101 0,09527467 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04530101 0,09519146 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,04530101 0,0951084 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04530101 0,09502548 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04530101 0,0949427 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,04530101 0,09486007 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,04530101 0,09477759 ! intracellular lipid transport GO:0032365 13 8 0,000 0,04530101 0,09469524 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04530101 0,09461304 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04530101 0,09453098 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,04530101 0,09444907 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,04530101 0,09436729 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,04530101 0,09428566 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,04530101 0,09420417 ! hormone catabolic process GO:0042447 17 8 0,000 0,04530101 0,09412282 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04530101 0,09404161 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,04530101 0,09396054 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,04530101 0,09387961 ! blastocyst growth GO:0001832 19 8 0,000 0,04530101 0,09379882 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04530101 0,09371816 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04530101 0,09363765 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,04530101 0,09355727 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04530101 0,09347704 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04530101 0,09339694 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,04530101 0,09331697 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,04530101 0,09323715 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,04530101 0,09315746 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,04530101 0,0930779 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,04530101 0,09299849 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,04530101 0,0929192 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04530101 0,09284005 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,04530101 0,09276104 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04530101 0,09268216 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04530101 0,09260342 GO:0000076|DNA replication checkpoint, ! NAD biosynthetic process GO:0009435 13 8 0,000 0,04530101 0,09252481 ! skeletal system morphogenesis GO:0048705 105 59 1,000 0,04581623 0,09349776 ! DNA damage response, signal transduction GO:0042770 128 60 1,000 0,04722041 0,09628162 ! camera-type eye development GO:0043010 116 60 1,000 0,04722041 0,0962001 ! negative regulation of response to stimulus GO:0048585 100 60 1,000 0,04722041 0,09611871 ! kidney development GO:0001822 122 60 1,000 0,04722041 0,09603746 ! ear development GO:0043583 103 62 1,000 0,05007543 0,10175802 ! regulation of developmental growth GO:0048638 15 9 0,000 0,05081822 0,10318028 ! axon extension GO:0048675 15 9 0,000 0,05081822 0,10309328 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,05081822 0,10300643 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,05081822 0,10291972 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05081822 0,10283316 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,05081822 0,10274675 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,05081822 0,10266048 ! phosphate transport GO:0006817 19 9 0,000 0,05081822 0,10257435 ! reproductive behavior GO:0019098 19 9 0,000 0,05081822 0,10248837 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05081822 0,10240254 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,05081822 0,10231684 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,05081822 0,10223129 ! RNA methylation GO:0001510 15 9 0,000 0,05081822 0,10214589 ! elastic fiber assembly GO:0048251 15 9 0,000 0,05081822 0,10206062 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,05081822 0,1019755 ! regulation of histone modification GO:0031056 12 9 0,000 0,05081822 0,10189052 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,05081822 0,10180569 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,05081822 0,10172099 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,05081822 0,10163643 ! chemosensory behavior GO:0007635 20 9 0,000 0,05081822 0,10155202 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,05081822 0,10146774 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05081822 0,10138361 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,05081822 0,10129961 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,05081822 0,10121575 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,05081822 0,10113203 ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05081822 0,10104845 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,05081822 0,10096501 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,05081822 0,10088171 ! T cell selection GO:0045058 23 9 0,000 0,05081822 0,10079854 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,05081822 0,10071551 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05081822 0,10063262 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,05081822 0,10054986 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05081822 0,10046724 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05081822 0,10038475 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05081822 0,1003024 ! mannose metabolic process GO:0006013 13 9 0,000 0,05081822 0,10022019 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,05081822 0,10013811 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,05081822 0,10005616 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,05081822 0,09997435 ! receptor clustering GO:0043113 18 9 0,000 0,05081822 0,09989267 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,05081822 0,09981112 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05081822 0,09972971 ! ruffle organization GO:0031529 15 9 0,000 0,05081822 0,09964843 ! retinol metabolic process GO:0042572 18 9 0,000 0,05081822 0,09956729 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,05081822 0,09948627 ! behavioral fear response GO:0001662 22 9 0,000 0,05081822 0,09940539 GO:0002209|behavioral defense response, ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,05081822 0,09932464 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,05081822 0,09924402 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,05081822 0,09916353 GO:0030204|chondroitin sulfate metabolic process, ! motor axon guidance GO:0008045 16 9 0,000 0,05081822 0,09908317 ! protein heterooligomerization GO:0051291 16 9 0,000 0,05081822 0,09900294 ! oligodendrocyte development GO:0014003 10 9 0,000 0,05081822 0,09892284 ! alpha-beta T cell differentiation GO:0046632 21 9 0,000 0,05081822 0,09884287 ! segment specification GO:0007379 13 9 0,000 0,05081822 0,09876303 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05081822 0,09868332 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,05081822 0,09860373 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05081822 0,09852428 ! response to amine stimulus GO:0014075 13 9 0,000 0,05081822 0,09844495 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05081822 0,09836575 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,05081822 0,09828668 ! erythrocyte development GO:0048821 15 9 0,000 0,05081822 0,09820773 ! regulation of mitochondrial membrane potential GO:0051881 17 9 0,000 0,05081822 0,09812891 ! renal water homeostasis GO:0003091 14 9 0,000 0,05081822 0,09805022 ! postreplication repair GO:0006301 22 9 0,000 0,05081822 0,09797166 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,05081822 0,09789322 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,05081822 0,0978149 ! icosanoid secretion GO:0032309 15 9 0,000 0,05081822 0,09773671 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,05081822 0,09765865 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05081822 0,09758071 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,05081822 0,09750289 ! regulation of cell division GO:0051302 15 9 0,000 0,05081822 0,0974252 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,05081822 0,09734763 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,05081822 0,09727019 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05081822 0,09719287 ! sterol catabolic process GO:0016127 11 9 0,000 0,05081822 0,09711567 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05081822 0,09703859 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,05081822 0,09696164 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,05081822 0,09688481 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,05081822 0,0968081 GO:0000084|S phase of mitotic cell cycle, ! musculoskeletal movement GO:0050881 14 9 0,000 0,05081822 0,09673151 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,05081822 0,09665504 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05081822 0,09657869 ! purine base metabolic process GO:0006144 21 9 0,000 0,05081822 0,09650247 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,05081822 0,09642636 ! pigment granule transport GO:0051904 17 9 0,000 0,05081822 0,09635038 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,05081822 0,09627451 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,05081822 0,09619876 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05081822 0,09612314 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05081822 0,09604763 ! mitochondrion localization GO:0051646 15 9 0,000 0,05081822 0,09597224 ! detection of external stimulus GO:0009581 91 63 1,000 0,05152583 0,09723226 ! cellular amino acid catabolic process GO:0009063 101 63 1,000 0,05152583 0,09715606 ! embryonic limb morphogenesis GO:0030326 125 65 1,000 0,05447127 0,1026295 GO:0035113|embryonic appendage morphogenesis, ! germ cell development GO:0007281 118 65 1,000 0,05447127 0,10254919 ! myeloid cell differentiation GO:0030099 111 65 1,000 0,05447127 0,10246901 ! extracellular matrix organization GO:0030198 133 66 1,000 0,05596588 0,10519836 ! developmental maturation GO:0021700 116 66 1,000 0,05596588 0,10511624 ! cell projection assembly GO:0030031 120 66 1,000 0,05596588 0,10503425 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,05630372 0,10558594 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05630372 0,1055037 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,05630372 0,1054216 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05630372 0,10533962 ! synapsis GO:0007129 13 10 0,000 0,05630372 0,10525777 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,05630372 0,10517605 ! N-glycan processing GO:0006491 20 10 0,000 0,05630372 0,10509446 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,05630372 0,10501299 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,05630372 0,10493165 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,05630372 0,10485043 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,05630372 0,10476934 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,05630372 0,10468837 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,05630372 0,10460753 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,05630372 0,10452682 ! androgen metabolic process GO:0008209 17 10 0,000 0,05630372 0,10444623 ! phospholipid efflux GO:0033700 16 10 0,000 0,05630372 0,10436576 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05630372 0,10428542 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,05630372 0,1042052 ! pathogenesis GO:0009405 13 10 0,000 0,05630372 0,1041251 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05630372 0,10404513 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,05630372 0,10396528 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,05630372 0,10388555 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,05630372 0,10380594 ! endoderm development GO:0007492 16 10 0,000 0,05630372 0,10372646 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,05630372 0,1036471 ! arginine catabolic process GO:0006527 13 10 0,000 0,05630372 0,10356786 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05630372 0,10348874 ! proline metabolic process GO:0006560 13 10 0,000 0,05630372 0,10340974 ! L-serine metabolic process GO:0006563 18 10 0,000 0,05630372 0,10333086 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,05630372 0,1032521 ! V(D)J recombination GO:0033151 28 10 0,000 0,05630372 0,10317346 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05630372 0,10309494 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,05630372 0,10301654 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,05630372 0,10293826 ! B cell proliferation GO:0042100 18 10 0,000 0,05630372 0,1028601 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,05630372 0,10278206 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,05630372 0,10270414 ! multicellular organism growth GO:0035264 18 10 0,000 0,05630372 0,10262633 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,05630372 0,10254864 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,05630372 0,10247107 ! epithelial cell development GO:0002064 20 10 0,000 0,05630372 0,10239362 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,05630372 0,10231628 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05630372 0,10223906 ! macroautophagy GO:0016236 17 10 0,000 0,05630372 0,10216196 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,05630372 0,10208497 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,05630372 0,1020081 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,05630372 0,10193134 ! copper ion homeostasis GO:0055070 13 10 0,000 0,05630372 0,1018547 ! alpha-beta T cell activation GO:0046631 23 10 0,000 0,05630372 0,10177818 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,05630372 0,10170177 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,05630372 0,10162547 ! blastoderm segmentation GO:0007350 18 10 0,000 0,05630372 0,10154929 ! response to dsRNA GO:0043331 20 10 0,000 0,05630372 0,10147323 ! DNA ligation GO:0006266 19 10 0,000 0,05630372 0,10139727 ! melanosome localization GO:0032400 16 10 0,000 0,05630372 0,10132143 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,05630372 0,10124571 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,05630372 0,10117009 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05630372 0,10109459 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,05630372 0,10101921 ! mRNA cleavage GO:0006379 17 10 0,000 0,05630372 0,10094393 ! protein sumoylation GO:0016925 15 10 0,000 0,05630372 0,10086877 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05630372 0,10079372 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,05630372 0,10071878 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,05630372 0,10064395 ! salivary gland development GO:0007431 27 10 0,000 0,05630372 0,10056923 ! prophase GO:0051324 15 10 0,000 0,05630372 0,10049463 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05630372 0,10042013 ! apical protein localization GO:0045176 15 10 0,000 0,05630372 0,10034575 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,05630372 0,10027147 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,05630372 0,10019731 ! midbrain development GO:0030901 13 10 0,000 0,05630372 0,10012325 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05630372 0,1000493 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,05630372 0,09997547 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,05630372 0,09990174 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,05630372 0,09982812 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05630372 0,09975461 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,05630372 0,0996812 ! detection of calcium ion GO:0005513 23 10 0,000 0,05630372 0,09960791 ! oocyte development GO:0048599 17 10 0,000 0,05630372 0,09953472 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05630372 0,09946164 ! blastocyst formation GO:0001825 17 10 0,000 0,05630372 0,09938867 ! cerebellar cortex development GO:0021695 15 10 0,000 0,05630372 0,0993158 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,05630372 0,09924304 ! activation of innate immune response GO:0002218 12 10 0,000 0,05630372 0,09917039 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,05630372 0,09909785 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,05630372 0,09902541 ! response to nicotine GO:0035094 20 10 0,000 0,05630372 0,09895307 ! establishment of cell polarity GO:0030010 16 10 0,000 0,05630372 0,09888084 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,05630372 0,09880872 ! hexose catabolic process GO:0019320 104 67 1,000 0,0574748 0,10079036 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 1,000 0,0574748 0,10071695 ! adaptive immune response GO:0002250 119 67 1,000 0,0574748 0,10064365 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,05899782 0,10323545 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! regulation of lipase activity GO:0060191 130 68 1,000 0,05899782 0,10316043 ! urogenital system development GO:0001655 137 69 1,000 0,06053472 0,1057709 ! respiratory burst GO:0045730 17 11 0,000 0,06175771 0,1078295 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,06175771 0,1077513 ! neuron fate specification GO:0048665 17 11 0,000 0,06175771 0,10767322 ! telencephalon cell migration GO:0022029 20 11 0,000 0,06175771 0,10759525 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,06175771 0,1075174 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,06175771 0,10743966 ! thyroid gland development GO:0030878 26 11 0,000 0,06175771 0,10736203 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,06175771 0,10728451 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,06175771 0,1072071 ! response to pain GO:0048265 24 11 0,000 0,06175771 0,10712981 ! T cell proliferation GO:0042098 26 11 0,000 0,06175771 0,10705263 ! bone resorption GO:0045453 16 11 0,000 0,06175771 0,10697556 ! ventral spinal cord development GO:0021517 21 11 0,000 0,06175771 0,10689859 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06175771 0,10682174 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06175771 0,106745 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,06175771 0,10666838 ! melanocyte differentiation GO:0030318 21 11 0,000 0,06175771 0,10659186 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,06175771 0,10651545 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,06175771 0,10643914 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,06175771 0,10636295 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,06175771 0,10628687 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of intracellular pH GO:0051453 19 11 0,000 0,06175771 0,1062109 ! lipid digestion GO:0044241 18 11 0,000 0,06175771 0,10613503 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,06175771 0,10605928 ! UV protection GO:0009650 19 11 0,000 0,06175771 0,10598363 ! adult heart development GO:0007512 14 11 0,000 0,06175771 0,10590809 ! chondrocyte differentiation GO:0002062 24 11 0,000 0,06175771 0,10583265 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06175771 0,10575733 ! temperature homeostasis GO:0001659 17 11 0,000 0,06175771 0,10568211 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,06175771 0,105607 ! negative regulation of ossification GO:0030279 26 11 0,000 0,06175771 0,10553199 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,06175771 0,10545709 ! regulation of organ growth GO:0046620 13 11 0,000 0,06175771 0,1053823 ! pigment granule localization GO:0051875 20 11 0,000 0,06175771 0,10530762 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,06175771 0,10523304 ! vasoconstriction GO:0042310 18 11 0,000 0,06175771 0,10515856 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06175771 0,10508419 ! embryonic axis specification GO:0000578 18 11 0,000 0,06175771 0,10500993 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,06175771 0,10493577 ! snRNA metabolic process GO:0016073 24 11 0,000 0,06175771 0,10486171 GO:0016180|snRNA processing, ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,06175771 0,10478776 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,06175771 0,10471392 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,06175771 0,10464017 ! zymogen activation GO:0031638 15 11 0,000 0,06175771 0,10456654 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,06175771 0,104493 ! neuroblast proliferation GO:0007405 24 11 0,000 0,06175771 0,10441957 ! nucleosome positioning GO:0016584 15 11 0,000 0,06175771 0,10434624 ! regulation of isotype switching GO:0045191 22 11 0,000 0,06175771 0,10427302 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,06175771 0,10419989 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,06175771 0,10412687 ! acid secretion GO:0046717 18 11 0,000 0,06175771 0,10405395 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06175771 0,10398114 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,06175771 0,10390842 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,06175771 0,10383581 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,06175771 0,1037633 ! oocyte differentiation GO:0009994 18 11 0,000 0,06175771 0,10369089 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,06175771 0,10361858 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 27 11 0,000 0,06175771 0,10354637 ! cholesterol efflux GO:0033344 19 11 0,000 0,06175771 0,10347427 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,06175771 0,10340226 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06175771 0,10333035 ! negative regulation of glucose import GO:0046325 17 11 0,000 0,06175771 0,10325855 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 25 11 0,000 0,06175771 0,10318684 ! embryonic gut development GO:0048566 15 11 0,000 0,06175771 0,10311523 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,06175771 0,10304372 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,06175771 0,10297231 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,06175771 0,102901 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,06175771 0,10282979 ! defense response to fungus GO:0050832 13 11 0,000 0,06175771 0,10275868 ! developmental induction GO:0031128 19 11 0,000 0,06175771 0,10268766 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,06175771 0,10261674 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06175771 0,10254593 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,06175771 0,1024752 ! sequestering of metal ion GO:0051238 14 11 0,000 0,06175771 0,10240458 ! lamellipodium assembly GO:0030032 20 11 0,000 0,06175771 0,10233405 ! regulation of embryonic development GO:0045995 27 11 0,000 0,06175771 0,10226362 ! nucleus localization GO:0051647 19 11 0,000 0,06175771 0,10219329 ! regulation of synapse organization GO:0050807 17 11 0,000 0,06175771 0,10212306 ! appendage morphogenesis GO:0035107 135 70 1,000 0,06208529 0,10259424 GO:0035108|limb morphogenesis, ! amine catabolic process GO:0009310 117 71 1,000 0,06364933 0,10510658 ! appendage development GO:0048736 136 71 1,000 0,06364933 0,10503449 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 1,000 0,06364933 0,1049625 ! phosphoinositide metabolic process GO:0030384 128 72 1,000 0,06522664 0,10748992 ! carbohydrate transport GO:0008643 110 72 1,000 0,06522664 0,10741635 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,06718035 0,11055809 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,06718035 0,11048252 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,06718035 0,11040706 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,06718035 0,11033169 ! virus-host interaction GO:0019048 29 12 0,000 0,06718035 0,11025643 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,06718035 0,11018128 ! cartilage condensation GO:0001502 20 12 0,000 0,06718035 0,11010622 ! mating GO:0007618 17 12 0,000 0,06718035 0,11003127 ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,06718035 0,10995642 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,06718035 0,10988167 ! hippocampus development GO:0021766 26 12 0,000 0,06718035 0,10980702 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,06718035 0,10973247 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,06718035 0,10965803 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06718035 0,10958368 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,06718035 0,10950944 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,06718035 0,1094353 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,06718035 0,10936125 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,06718035 0,10928731 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,06718035 0,10921347 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,06718035 0,10913972 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,06718035 0,10906608 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,06718035 0,10899254 ! polyamine metabolic process GO:0006595 17 12 0,000 0,06718035 0,10891909 ! focal adhesion formation GO:0048041 35 12 0,000 0,06718035 0,10884574 ! mitotic spindle organization GO:0007052 21 12 0,000 0,06718035 0,1087725 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,06718035 0,10869935 ! forebrain cell migration GO:0021885 21 12 0,000 0,06718035 0,1086263 ! asymmetric protein localization GO:0008105 20 12 0,000 0,06718035 0,10855335 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,06718035 0,10848049 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,06718035 0,10840773 ! entry into host cell GO:0030260 32 12 0,000 0,06718035 0,10833507 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 26 12 0,000 0,06718035 0,10826251 ! monoamine transport GO:0015844 18 12 0,000 0,06718035 0,10819005 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06718035 0,10811768 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,06718035 0,10804541 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,06718035 0,10797323 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,06718035 0,10790116 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06718035 0,10782917 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,06718035 0,10775729 ! protein homotetramerization GO:0051289 21 12 0,000 0,06718035 0,1076855 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,06718035 0,1076138 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,06718035 0,1075422 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,06718035 0,1074707 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,06718035 0,10739929 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06718035 0,10732798 ! cranial nerve development GO:0021545 20 12 0,000 0,06718035 0,10725676 ! fucose catabolic process GO:0019317 22 12 0,000 0,06718035 0,10718563 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,06718035 0,1071146 ! histone methylation GO:0016571 26 12 0,000 0,06718035 0,10704366 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,06718035 0,10697282 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,06718035 0,10690207 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,06718035 0,10683142 ! spleen development GO:0048536 22 12 0,000 0,06718035 0,10676085 ! digestive tract morphogenesis GO:0048546 26 12 0,000 0,06718035 0,10669038 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,06718035 0,10662001 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,06718035 0,10654972 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,06718035 0,10647953 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,06718035 0,10640943 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,06718035 0,10633943 ! response to cold GO:0009409 17 12 0,000 0,06718035 0,10626951 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,06718035 0,10619969 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,06718035 0,10612996 ! meiosis GO:0007126 121 74 1,000 0,06842022 0,10801775 GO:0051327|M phase of meiotic cell cycle, ! eye development GO:0001654 143 74 1,000 0,06842022 0,10794691 ! cell-matrix adhesion GO:0007160 163 75 1,000 0,0700361 0,11042388 ! regulation of vesicle-mediated transport GO:0060627 119 75 1,000 0,0700361 0,11035157 ! meiotic cell cycle GO:0051321 122 75 1,000 0,0700361 0,11027935 ! lymphocyte differentiation GO:0030098 167 75 1,000 0,0700361 0,11020722 ! monosaccharide catabolic process GO:0046365 115 76 1,000 0,07166443 0,11269583 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07257184 0,11404823 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,07257184 0,11397379 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,07257184 0,11389944 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,07257184 0,11382519 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,07257184 0,11375104 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,07257184 0,11367698 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,07257184 0,11360302 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,07257184 0,11352916 ! endocrine pancreas development GO:0031018 22 13 0,000 0,07257184 0,11345539 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,07257184 0,11338171 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,07257184 0,11330814 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,07257184 0,11323466 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,07257184 0,11316127 ! methionine metabolic process GO:0006555 27 13 0,000 0,07257184 0,11308798 ! plasma membrane organization GO:0007009 24 13 0,000 0,07257184 0,11301478 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,07257184 0,11294168 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,07257184 0,11286868 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,07257184 0,11279576 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,07257184 0,11272294 ! response to X-ray GO:0010165 25 13 0,000 0,07257184 0,11265022 ! cytokine metabolic process GO:0042107 22 13 0,000 0,07257184 0,11257759 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,07257184 0,11250505 ! exocrine system development GO:0035272 32 13 0,000 0,07257184 0,11243261 ! negative regulation of mitotic cell cycle GO:0045930 33 13 0,000 0,07257184 0,11236026 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,07257184 0,112288 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,07257184 0,11221584 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,07257184 0,11214376 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,07257184 0,11207178 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,07257184 0,1119999 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,07257184 0,1119281 ! regulation of cellular pH GO:0030641 22 13 0,000 0,07257184 0,1118564 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07257184 0,11178479 ! ribosome assembly GO:0042255 17 13 0,000 0,07257184 0,11171327 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,07257184 0,11164184 ! chromatin silencing GO:0006342 26 13 0,000 0,07257184 0,11157051 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,07257184 0,11149926 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07257184 0,11142811 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,07257184 0,11135704 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,07257184 0,11128607 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,07257184 0,11121519 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,07257184 0,11114439 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,07257184 0,11107369 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,07257184 0,11100308 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,07257184 0,11093255 ! insulin secretion GO:0030073 23 13 0,000 0,07257184 0,11086212 ! actin filament polymerization GO:0030041 24 13 0,000 0,07257184 0,11079178 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,07257184 0,11072152 ! acrosome reaction GO:0007340 18 13 0,000 0,07257184 0,11065136 ! positive regulation of lymphocyte activation GO:0051251 127 77 1,000 0,07330503 0,11169849 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 1,000 0,07662225 0,1166792 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 1,000 0,07662225 0,1166054 ! positive regulation of phosphorylation GO:0042327 129 79 1,000 0,07662225 0,11653169 ! rRNA transcription GO:0009303 25 14 0,000 0,07793234 0,11844928 ! lactation GO:0007595 26 14 0,000 0,07793234 0,1183745 ! reproductive cellular process GO:0048610 20 14 0,000 0,07793234 0,11829981 ! tRNA modification GO:0006400 20 14 0,000 0,07793234 0,11822522 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,07793234 0,11815073 ! regulation of S phase GO:0033261 23 14 0,000 0,07793234 0,11807633 ! water transport GO:0006833 21 14 0,000 0,07793234 0,11800202 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,07793234 0,1179278 ! non-recombinational repair GO:0000726 25 14 0,000 0,07793234 0,11785368 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,07793234 0,11777965 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,07793234 0,11770572 ! hair follicle morphogenesis GO:0031069 26 14 0,000 0,07793234 0,11763187 ! RNA polyadenylation GO:0043631 30 14 0,000 0,07793234 0,11755812 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,07793234 0,11748446 ! palate development GO:0060021 31 14 0,000 0,07793234 0,1174109 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 0,000 0,07793234 0,11733742 ! regulated secretory pathway GO:0045055 23 14 0,000 0,07793234 0,11726404 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,07793234 0,11719075 ! arginine metabolic process GO:0006525 17 14 0,000 0,07793234 0,11711755 ! regulation of heart rate GO:0002027 24 14 0,000 0,07793234 0,11704445 ! organic alcohol transport GO:0015850 29 14 0,000 0,07793234 0,11697143 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,07793234 0,11689851 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 0,000 0,07793234 0,11682567 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,07793234 0,11675293 ! neutral amino acid transport GO:0015804 26 14 0,000 0,07793234 0,11668028 ! L-amino acid transport GO:0015807 30 14 0,000 0,07793234 0,11660771 ! bone mineralization GO:0030282 17 14 0,000 0,07793234 0,11653524 ! stem cell development GO:0048864 43 14 0,000 0,07793234 0,11646286 GO:0019827|stem cell maintenance, ! T cell differentiation in the thymus GO:0033077 31 14 0,000 0,07793234 0,11639057 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07793234 0,11631837 ! cerebellum development GO:0021549 21 14 0,000 0,07793234 0,11624625 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,07793234 0,11617423 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,07793234 0,11610229 ! response to gamma radiation GO:0010332 28 14 0,000 0,07793234 0,11603045 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,07793234 0,11595869 ! cofactor transport GO:0051181 26 14 0,000 0,07793234 0,11588702 ! NADP metabolic process GO:0006739 24 14 0,000 0,07793234 0,11581544 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,07793234 0,11574395 ! intestinal absorption GO:0050892 25 14 0,000 0,07793234 0,11567255 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,07793234 0,11560124 ! oxygen transport GO:0015671 21 14 0,000 0,07793234 0,11553001 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07793234 0,11545887 ! male genitalia development GO:0030539 24 14 0,000 0,07793234 0,11538782 ! regulation of axon extension GO:0030516 37 14 0,000 0,07793234 0,11531685 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,07793234 0,11524598 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,07829849 0,11571631 ! muscle cell differentiation GO:0042692 159 80 1,000 0,07829849 0,11564528 ! T cell activation GO:0042110 168 81 1,000 0,07998622 0,11806555 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 1,000 0,07998622 0,11799316 GO:0045937|positive regulation of phosphate metabolic process, ! cell-substrate adhesion GO:0031589 171 81 1,000 0,07998622 0,11792086 ! regulation of cAMP biosynthetic process GO:0030817 161 82 1,000 0,08168526 0,12035195 ! response to drug GO:0042493 143 82 1,000 0,08168526 0,1202783 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,08168526 0,12020473 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,08326203 0,12245015 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,08326203 0,12237535 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,08326203 0,12230064 ! superoxide anion generation GO:0042554 20 15 0,000 0,08326203 0,12222602 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,08326203 0,12215149 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,08326203 0,12207706 ! copper ion transport GO:0006825 20 15 0,000 0,08326203 0,12200271 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,08326203 0,12192845 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,08326203 0,12185429 ! sulfate transport GO:0008272 23 15 0,000 0,08326203 0,12178021 ! response to cAMP GO:0051591 22 15 0,000 0,08326203 0,12170623 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,08326203 0,12163233 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,08326203 0,12155852 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,08326203 0,12148481 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,08326203 0,12141118 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,08326203 0,12133764 ! response to hexose stimulus GO:0009746 22 15 0,000 0,08326203 0,12126419 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,08326203 0,12119083 ! pituitary gland development GO:0021983 29 15 0,000 0,08326203 0,12111756 ! vesicle coating GO:0006901 33 15 0,000 0,08326203 0,12104438 ! regulation of the force of heart contraction GO:0002026 26 15 0,000 0,08326203 0,12097128 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,08326203 0,12089828 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 0,000 0,08326203 0,12082536 ! regulation of exocytosis GO:0017157 22 15 0,000 0,08326203 0,12075253 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,08326203 0,12067979 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,08326203 0,12060713 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,08326203 0,12053457 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,08326203 0,12046209 ! histone deacetylation GO:0016575 20 15 0,000 0,08326203 0,12038969 ! mRNA splice site selection GO:0006376 38 15 0,000 0,08326203 0,12031739 ! tissue regeneration GO:0042246 26 15 0,000 0,08326203 0,12024517 ! water homeostasis GO:0030104 27 15 0,000 0,08326203 0,12017303 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,08326203 0,12010099 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,08326203 0,12002903 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,08326203 0,11995715 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,08326203 0,11988537 ! dopamine metabolic process GO:0042417 35 15 0,000 0,08326203 0,11981366 ! heme biosynthetic process GO:0006783 29 15 0,000 0,08326203 0,11974205 ! cell killing GO:0001906 29 15 0,000 0,08326203 0,11967052 ! detection of bacterium GO:0016045 18 15 0,000 0,08326203 0,11959907 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,08326203 0,11952771 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,08326203 0,11945644 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,08326203 0,11938525 ! peptide hormone processing GO:0016486 23 15 0,000 0,08326203 0,11931414 ! regulation of lyase activity GO:0051339 160 83 1,000 0,08339543 0,11943417 ! regulation of cAMP metabolic process GO:0030814 168 84 1,000 0,08511654 0,12182653 ! negative regulation of transport GO:0051051 153 84 1,000 0,08511654 0,1217541 ! regulation of ligase activity GO:0051340 142 84 1,000 0,08511654 0,12168176 ! positive regulation of cell activation GO:0050867 145 85 1,000 0,08684842 0,1240839 GO:0002696|positive regulation of leukocyte activation, ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,08856109 0,12645578 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,08856109 0,12638078 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,08856109 0,12630587 ! bone remodeling GO:0046849 27 16 0,000 0,08856109 0,12623104 ! filopodium assembly GO:0046847 32 16 0,000 0,08856109 0,1261563 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,08856109 0,12608165 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,08856109 0,12600709 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,08856109 0,12593262 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,08856109 0,12585824 ! startle response GO:0001964 28 16 0,000 0,08856109 0,12578394 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,08856109 0,12570973 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,08856109 0,12563561 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,08856109 0,12556158 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,08856109 0,12548763 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,08856109 0,12541377 ! protein polyubiquitination GO:0000209 34 16 0,000 0,08856109 0,12534 ! glutamate metabolic process GO:0006536 22 16 0,000 0,08856109 0,12526631 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,08856109 0,12519271 ! response to osmotic stress GO:0006970 25 16 0,000 0,08856109 0,1251192 ! lysosomal transport GO:0007041 26 16 0,000 0,08856109 0,12504577 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,08856109 0,12497243 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,08856109 0,12489918 ! intermediate filament-based process GO:0045103 32 16 0,000 0,08856109 0,12482601 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,08856109 0,12475292 ! negative regulation of immune response GO:0050777 35 16 0,000 0,08856109 0,12467993 ! axon cargo transport GO:0008088 43 16 0,000 0,08856109 0,12460701 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,08856109 0,12453419 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,08856109 0,12446145 ! positive regulation of protein import into nucleus GO:0042307 30 16 0,000 0,08856109 0,12438879 ! DNA replication initiation GO:0006270 27 16 0,000 0,08856109 0,12431622 ! neuron recognition GO:0008038 35 16 0,000 0,08856109 0,12424373 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,08856109 0,12417133 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,08856109 0,12409901 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,08856109 0,12402677 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,08856109 0,12395462 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,08856109 0,12388255 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,08856109 0,12381057 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,08856109 0,12373867 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,08856109 0,12366686 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,08856109 0,12359512 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,08856109 0,12352348 ! defense response to virus GO:0051607 37 16 0,000 0,08856109 0,12345191 ! alcohol catabolic process GO:0046164 130 86 1,000 0,08859087 0,12342191 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 1,000 0,09034373 0,12579109 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! nitrogen compound catabolic process GO:0044270 143 87 1,000 0,09034373 0,12571834 ! cellular respiration GO:0045333 135 88 1,000 0,09210681 0,12809767 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,0938297 0,13041841 ! metencephalon development GO:0022037 30 17 0,000 0,0938297 0,13034311 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,0938297 0,1302679 ! negative regulation of cell cycle process GO:0010948 32 17 0,000 0,0938297 0,13019277 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,0938297 0,13011773 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,0938297 0,13004278 ! signal complex assembly GO:0007172 41 17 0,000 0,0938297 0,12996791 ! endothelial cell migration GO:0043542 28 17 0,000 0,0938297 0,12989313 ! inositol metabolic process GO:0006020 28 17 0,000 0,0938297 0,12981844 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,0938297 0,12974383 ! limbic system development GO:0021761 36 17 0,000 0,0938297 0,12966931 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,0938297 0,12959487 ! adult walking behavior GO:0007628 33 17 0,000 0,0938297 0,12952052 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,0938297 0,12944625 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,0938297 0,12937207 ! regulation of viral genome replication GO:0045069 28 17 0,000 0,0938297 0,12929798 ! myoblast differentiation GO:0045445 45 17 0,000 0,0938297 0,12922396 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,0938297 0,12915004 ! cardiac muscle tissue development GO:0048738 31 17 0,000 0,0938297 0,1290762 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,0938297 0,12900244 ! glycine metabolic process GO:0006544 28 17 0,000 0,0938297 0,12892876 ! NAD metabolic process GO:0019674 29 17 0,000 0,0938297 0,12885517 ! membrane budding GO:0006900 37 17 0,000 0,0938297 0,12878167 ! DNA integration GO:0015074 29 17 0,000 0,0938297 0,12870825 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,0938297 0,12863491 ! regulation of protein binding GO:0043393 33 17 0,000 0,0938297 0,12856165 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,0938297 0,12848848 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,0938297 0,1284154 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,0938297 0,12834239 ! genitalia development GO:0048806 30 17 0,000 0,0938297 0,12826947 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,0938297 0,12819663 GO:0002712|regulation of B cell mediated immunity, ! neutrophil chemotaxis GO:0030593 27 17 0,000 0,0938297 0,12812387 ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,0938297 0,1280512 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,0938297 0,12797861 ! steroid catabolic process GO:0006706 31 17 0,000 0,0938297 0,1279061 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,0938297 0,12783367 ! gas transport GO:0015669 25 17 0,000 0,0938297 0,12776133 ! organic cation transport GO:0015695 31 17 0,000 0,0938297 0,12768906 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,0938297 0,12761688 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,0938297 0,12754478 ! microspike assembly GO:0030035 36 17 0,000 0,0938297 0,12747276 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,0938297 0,12740083 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 1,000 0,09566295 0,12981672 ! regulation of cell cycle process GO:0010564 149 90 1,000 0,09566295 0,12974355 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,09906803 0,13428602 ! neuron maturation GO:0042551 42 18 0,000 0,09906803 0,1342104 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,09906803 0,13413488 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,09906803 0,13405944 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,09906803 0,13398408 ! memory GO:0007613 31 18 0,000 0,09906803 0,13390881 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,09906803 0,13383362 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,09906803 0,13375852 ! patterning of blood vessels GO:0001569 39 18 0,000 0,09906803 0,1336835 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,09906803 0,13360856 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,09906803 0,13353371 ! epidermis morphogenesis GO:0048730 40 18 0,000 0,09906803 0,13345895 ! glutamine metabolic process GO:0006541 29 18 0,000 0,09906803 0,13338426 ! response to retinoic acid GO:0032526 26 18 0,000 0,09906803 0,13330966 ! cell-substrate junction assembly GO:0007044 54 18 0,000 0,09906803 0,13323515 ! response to fungus GO:0009620 21 18 0,000 0,09906803 0,13316071 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,09906803 0,13308636 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,09906803 0,1330121 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,09906803 0,13293791 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,09906803 0,13286381 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,09906803 0,13278979 ! vitamin transport GO:0051180 27 18 0,000 0,09906803 0,13271586 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,09906803 0,132642 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,09906803 0,13256823 GO:0033014|tetrapyrrole biosynthetic process, ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,09906803 0,13249454 ! nerve development GO:0021675 28 18 0,000 0,09906803 0,13242093 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,09906803 0,13234741 ! positive regulation of MAP kinase activity GO:0043406 160 93 1,000 0,10106953 0,13494633 ! regulation of nucleotide metabolic process GO:0006140 182 93 1,000 0,10106953 0,13487149 ! carbohydrate biosynthetic process GO:0016051 141 93 1,000 0,10106953 0,13479672 ! regulation of T cell activation GO:0050863 158 94 1,000 0,10289035 0,13714913 ! protein secretion GO:0009306 39 19 0,000 0,10427625 0,13891952 ! positive regulation of translation GO:0045727 30 19 0,000 0,10427625 0,13884264 ! negative regulation of defense response GO:0031348 25 19 0,000 0,10427625 0,13876585 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,10427625 0,13868914 ! skin development GO:0043588 36 19 0,000 0,10427625 0,13861252 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,10427625 0,13853598 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,10427625 0,13845952 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,10427625 0,13838315 ! bile acid metabolic process GO:0008206 29 19 0,000 0,10427625 0,13830686 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,10427625 0,13823066 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,10427625 0,13815454 ! pigmentation during development GO:0048066 41 19 0,000 0,10427625 0,13807851 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,10427625 0,13800256 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to vitamin A GO:0033189 27 19 0,000 0,10427625 0,13792669 ! heme metabolic process GO:0042168 36 19 0,000 0,10427625 0,13785091 ! actin filament bundle formation GO:0051017 42 19 0,000 0,10427625 0,13777521 ! neuromuscular junction development GO:0007528 34 19 0,000 0,10427625 0,13769959 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,10427625 0,13762406 ! plasma membrane fusion GO:0045026 28 19 0,000 0,10427625 0,1375486 ! peptide cross-linking GO:0018149 37 19 0,000 0,10427625 0,13747323 ! protein export from nucleus GO:0006611 36 19 0,000 0,10427625 0,13739795 ! heart process GO:0003015 30 19 0,000 0,10427625 0,13732274 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,10427625 0,13724762 GO:0006692|prostanoid metabolic process, ! cellular pigmentation GO:0033059 36 19 0,000 0,10427625 0,13717258 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,10427625 0,13709762 ! cell-cell junction organization GO:0045216 35 19 0,000 0,10427625 0,13702275 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,10427625 0,13694795 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,10427625 0,13687324 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,10427625 0,13679861 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,10427625 0,13672406 ! cilium assembly GO:0042384 37 19 0,000 0,10427625 0,13664959 ! peptide hormone secretion GO:0030072 31 19 0,000 0,10427625 0,13657521 ! forebrain development GO:0030900 188 95 1,000 0,1047202 0,13708205 ! leukocyte differentiation GO:0002521 202 96 1,000 0,10655893 0,13941315 ! detection of stimulus GO:0051606 151 96 1,000 0,10655893 0,13933738 ! protein ubiquitination GO:0016567 217 97 1,000 0,10840636 0,1416761 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,10945453 0,14296829 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,10945453 0,14289072 ! positive regulation of ossification GO:0045778 47 20 0,000 0,10945453 0,14281323 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,10945453 0,14273583 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,10945453 0,1426585 ! cAMP metabolic process GO:0046058 36 20 0,000 0,10945453 0,14258127 ! response to vitamin GO:0033273 31 20 0,000 0,10945453 0,14250411 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,10945453 0,14242704 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,10945453 0,14235005 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,10945453 0,14227315 ! retinoid metabolic process GO:0001523 32 20 0,000 0,10945453 0,14219633 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,10945453 0,14211959 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,10945453 0,14204293 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,10945453 0,14196636 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,10945453 0,14188987 GO:0032392|DNA geometric change, ! cellular response to starvation GO:0009267 33 20 0,000 0,10945453 0,14181346 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,10945453 0,14173714 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,10945453 0,14166089 ! body fluid secretion GO:0007589 31 20 0,000 0,10945453 0,14158473 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,10945453 0,14150865 ! peptide secretion GO:0002790 35 20 0,000 0,10945453 0,14143265 ! stem cell differentiation GO:0048863 53 20 0,000 0,10945453 0,14135674 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,10945453 0,1412809 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,10945453 0,14120515 ! sensory perception of pain GO:0019233 30 20 0,000 0,10945453 0,14112947 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,10945453 0,14105388 ! diencephalon development GO:0021536 34 20 0,000 0,10945453 0,14097837 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,10945453 0,14090294 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,10945453 0,14082759 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,10945453 0,14075232 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,10945453 0,14067714 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,10945453 0,14060203 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,10945453 0,140527 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,10945453 0,14045205 ! regulation of glucose import GO:0046324 29 20 0,000 0,10945453 0,14037718 GO:0010827|regulation of glucose transport, ! actin filament-based movement GO:0030048 43 20 0,000 0,10945453 0,1403024 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,10945453 0,14022769 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,10945453 0,14015306 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,10945453 0,14007851 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 0,000 0,10945453 0,14000404 ! carboxylic acid catabolic process GO:0046395 156 98 1,000 0,11026234 0,14096238 GO:0016054|organic acid catabolic process, ! regulation of cell killing GO:0031341 42 21 0,000 0,11460305 0,14643385 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,11460305 0,14635612 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,11460305 0,14627848 ! hormone secretion GO:0046879 38 21 0,000 0,11460305 0,14620092 ! glycerol metabolic process GO:0006071 34 21 0,000 0,11460305 0,14612344 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,11460305 0,14604604 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,11460305 0,14596873 ! axis specification GO:0009798 38 21 0,000 0,11460305 0,1458915 ! ovarian follicle development GO:0001541 35 21 0,000 0,11460305 0,14581435 ! smooth muscle contraction GO:0006939 46 21 0,000 0,11460305 0,14573728 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,11460305 0,14566029 ! cell aging GO:0007569 44 21 0,000 0,11460305 0,14558338 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,11460305 0,14550656 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 0,000 0,11460305 0,14542982 ! cytolysis GO:0019835 24 21 0,000 0,11460305 0,14535315 ! vasodilation GO:0042311 39 21 0,000 0,11460305 0,14527657 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,11460305 0,14520007 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,11460305 0,14512365 ! oogenesis GO:0048477 36 21 0,000 0,11460305 0,14504731 ! DNA modification GO:0006304 34 21 0,000 0,11460305 0,14497105 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,11460305 0,14489487 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,11460305 0,14481877 ! positive regulation of inflammatory response GO:0050729 35 21 0,000 0,11460305 0,14474275 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,11460305 0,14466681 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,11460305 0,14459094 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,11460305 0,14451516 ! response to cytokine stimulus GO:0034097 63 21 0,000 0,11460305 0,14443946 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,11460305 0,14436384 ! collagen catabolic process GO:0030574 28 21 0,000 0,11460305 0,14428829 ! sperm-egg recognition GO:0035036 21 21 0,000 0,11460305 0,14421283 ! gut development GO:0048565 39 21 0,000 0,11460305 0,14413744 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 0,000 0,11972197 0,15049689 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,11972197 0,15041831 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,11972197 0,1503398 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,11972197 0,15026138 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,11972197 0,15018303 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,11972197 0,15010477 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,11972197 0,15002659 ! regeneration GO:0031099 41 22 0,000 0,11972197 0,14994849 ! keratinization GO:0031424 28 22 0,000 0,11972197 0,14987048 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,11972197 0,14979254 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,11972197 0,14971469 ! sensory perception of taste GO:0050909 28 22 0,000 0,11972197 0,14963691 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,11972197 0,14955922 ! vacuolar transport GO:0007034 36 22 0,000 0,11972197 0,14948161 ! lysosome organization GO:0007040 41 22 0,000 0,11972197 0,14940407 ! central nervous system neuron development GO:0021954 46 22 0,000 0,11972197 0,14932662 ! cellular response to reactive oxygen species GO:0034614 31 22 0,000 0,11972197 0,14924925 ! fucose metabolic process GO:0006004 39 22 0,000 0,11972197 0,14917196 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,11972197 0,14909475 ! ureteric bud development GO:0001657 43 22 0,000 0,11972197 0,14901762 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,11972197 0,14894057 GO:0060415|muscle tissue morphogenesis, ! renal system process GO:0003014 41 22 0,000 0,11972197 0,1488636 ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,11972197 0,1487867 ! response to glucocorticoid stimulus GO:0051384 38 22 0,000 0,11972197 0,14870989 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,11972197 0,14863316 ! sarcomere organization GO:0045214 30 22 0,000 0,11972197 0,1485565 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,11972197 0,14847993 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,11972197 0,14840343 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,11972197 0,14832701 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 0,000 0,11972197 0,14825067 ! protein stabilization GO:0050821 39 22 0,000 0,11972197 0,14817441 ! positive regulation of DNA replication GO:0045740 43 23 0,000 0,12481146 0,15439403 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 0,000 0,12481146 0,15431469 ! positive regulation of cell adhesion GO:0045785 56 23 0,000 0,12481146 0,15423543 ! myeloid leukocyte differentiation GO:0002573 40 23 0,000 0,12481146 0,15415625 ! gluconeogenesis GO:0006094 33 23 0,000 0,12481146 0,15407716 ! viral genome replication GO:0019079 41 23 0,000 0,12481146 0,15399815 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,12481146 0,15391921 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,12481146 0,15384036 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,12481146 0,15376159 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,12481146 0,1536829 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,12481146 0,15360429 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,12481146 0,15352576 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,12481146 0,15344731 ! response to ethanol GO:0045471 46 23 0,000 0,12481146 0,15336894 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,12481146 0,15329065 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,12481146 0,15321244 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,12481146 0,15313431 ! vesicle targeting GO:0006903 43 23 0,000 0,12481146 0,15305626 ! sex determination GO:0007530 47 23 0,000 0,12481146 0,15297829 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 0,000 0,12481146 0,1529004 ! regulation of viral reproduction GO:0050792 38 23 0,000 0,12481146 0,15282259 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,12481146 0,15274485 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,12481146 0,1526672 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,12481146 0,15258963 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,12481146 0,15251213 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,12481146 0,15243471 ! fatty acid transport GO:0015908 44 23 0,000 0,12481146 0,15235737 ! platelet activation GO:0030168 37 23 0,000 0,12481146 0,15228011 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,12481146 0,15220293 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,12481146 0,15212583 ! hormone transport GO:0009914 40 23 0,000 0,12481146 0,1520488 ! cell-cell recognition GO:0009988 25 23 0,000 0,12481146 0,15197185 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,12481146 0,15189498 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,12481146 0,15181819 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,12481146 0,15174148 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,12481146 0,15166484 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,1298717 0,15773413 GO:0016444|somatic cell DNA recombination, ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,1298717 0,15765455 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,1298717 0,15757505 ! vacuole organization GO:0007033 43 24 0,000 0,1298717 0,15749562 ! multicellular organismal response to stress GO:0033555 49 24 0,000 0,1298717 0,15741628 ! digestive system process GO:0022600 39 24 0,000 0,1298717 0,15733702 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,1298717 0,15725783 ! response to corticosteroid stimulus GO:0031960 41 24 0,000 0,1298717 0,15717873 ! regulation of alpha-beta T cell activation GO:0046634 42 24 0,000 0,1298717 0,15709971 ! lymphocyte proliferation GO:0046651 48 24 0,000 0,1298717 0,15702076 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,1298717 0,1569419 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,1298717 0,15686311 ! pentose metabolic process GO:0019321 35 24 0,000 0,1298717 0,1567844 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,1298717 0,15670578 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,1298717 0,15662723 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,1298717 0,15654876 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,1298717 0,15647036 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,1298717 0,15639205 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,1298717 0,15631382 ! regulation of amine transport GO:0051952 40 24 0,000 0,1298717 0,15623566 ! protein tetramerization GO:0051262 52 24 0,000 0,1298717 0,15615758 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 0,000 0,13490285 0,162126 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,13490285 0,16204506 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,13490285 0,1619642 ! phototransduction GO:0007602 33 25 0,000 0,13490285 0,16188342 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,13490285 0,16180272 GO:0006479|protein amino acid methylation, ! sperm motility GO:0030317 31 25 0,000 0,13490285 0,1617221 ! negative regulation of DNA replication GO:0008156 42 25 0,000 0,13490285 0,16164156 ! receptor metabolic process GO:0043112 46 25 0,000 0,13490285 0,1615611 ! chromosome condensation GO:0030261 45 25 0,000 0,13490285 0,16148072 ! response to starvation GO:0042594 42 25 0,000 0,13490285 0,16140043 ! coenzyme catabolic process GO:0009109 39 25 0,000 0,13490285 0,16132021 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,13490285 0,16124007 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,13490285 0,16116001 ! interaction with host GO:0051701 62 25 0,000 0,13490285 0,16108003 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,13490285 0,16100013 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 0,000 0,13490285 0,16092031 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,13490285 0,16084056 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! immunoglobulin production GO:0002377 55 25 0,000 0,13490285 0,1607609 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,13490285 0,16068132 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,13490285 0,16060181 ! cellular response to nutrient levels GO:0031669 41 25 0,000 0,13490285 0,16052238 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,13490285 0,16044303 ! telomere organization GO:0032200 43 25 0,000 0,13490285 0,16036376 GO:0000723|telomere maintenance, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,13990507 0,16622795 ! embryonic pattern specification GO:0009880 44 26 0,000 0,13990507 0,16614591 ! initiation of viral infection GO:0019059 57 26 0,000 0,13990507 0,16606394 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,13990507 0,16598205 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,13990507 0,16590025 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,13990507 0,16581853 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,13990507 0,16573688 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,13990507 0,16565532 GO:0051297|centrosome organization, ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 0,000 0,13990507 0,16557383 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,13990507 0,16549243 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,13990507 0,16541111 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,13990507 0,16532987 ! positive regulation of nuclear division GO:0051785 40 26 0,000 0,13990507 0,1652487 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,13990507 0,16516762 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,13990507 0,16508661 ! blastocyst development GO:0001824 49 26 0,000 0,13990507 0,16500569 ! leukocyte proliferation GO:0070661 52 26 0,000 0,13990507 0,16492484 GO:0032943|mononuclear cell proliferation, ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,13990507 0,16484408 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,13990507 0,16476339 ! neuron fate commitment GO:0048663 48 27 0,000 0,14487854 0,17053707 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,14487854 0,17045367 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,14487854 0,17037036 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,14487854 0,17028713 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,14487854 0,17020399 ! fat cell differentiation GO:0045444 50 27 0,000 0,14487854 0,17012092 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,14487854 0,17003793 ! mitochondrial membrane organization GO:0007006 57 27 0,000 0,14487854 0,16995503 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,14487854 0,1698722 ! autophagy GO:0006914 41 27 0,000 0,14487854 0,16978946 ! male gonad development GO:0008584 44 27 0,000 0,14487854 0,1697068 ! response to toxin GO:0009636 47 27 0,000 0,14487854 0,16962422 ! base-excision repair GO:0006284 41 27 0,000 0,14487854 0,16954171 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,14487854 0,16945929 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,14487854 0,16937695 ! glutathione metabolic process GO:0006749 39 27 0,000 0,14487854 0,16929469 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,14487854 0,16921251 ! negative regulation of neuron differentiation GO:0045665 42 27 0,000 0,14487854 0,1691304 ! circadian rhythm GO:0007623 50 28 0,000 0,14982341 0,1748182 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,14982341 0,17473346 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! negative regulation of protein modification process GO:0031400 60 28 0,000 0,14982341 0,1746488 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,14982341 0,17456422 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,14982341 0,17447973 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,14982341 0,17439532 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,14982341 0,17431099 ! positive regulation of T cell differentiation GO:0045582 42 28 0,000 0,14982341 0,17422674 ! synaptogenesis GO:0007416 42 28 0,000 0,14982341 0,17414257 ! peptidyl-tyrosine modification GO:0018212 50 28 0,000 0,14982341 0,17405848 ! lipid oxidation GO:0034440 43 28 0,000 0,14982341 0,17397448 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,14982341 0,17389055 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,14982341 0,17380671 ! translational initiation GO:0006413 65 29 0,000 0,15473985 0,17942365 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,15473985 0,17933722 ! regulation of pH GO:0006885 43 29 0,000 0,15473985 0,17925088 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,15473985 0,17916462 ! catechol metabolic process GO:0009712 54 29 0,000 0,15473985 0,17907844 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,15473985 0,17899234 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,15473985 0,17890633 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,15473985 0,1788204 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,15473985 0,17873455 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,15473985 0,17864879 ! response to organic cyclic substance GO:0014070 55 29 0,000 0,15473985 0,1785631 ! cell fate determination GO:0001709 60 29 0,000 0,15473985 0,1784775 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,15473985 0,17839198 ! detection of light stimulus GO:0009583 38 29 0,000 0,15473985 0,17830655 ! tissue homeostasis GO:0001894 48 29 0,000 0,15473985 0,17822119 GO:0048871|multicellular organismal homeostasis, ! phenol metabolic process GO:0018958 55 30 0,000 0,15962802 0,18376316 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,15962802 0,18367528 ! cell junction assembly GO:0034329 78 30 0,000 0,15962802 0,18358748 ! regulation of innate immune response GO:0045088 51 30 0,000 0,15962802 0,18349977 ! acute-phase response GO:0006953 49 30 0,000 0,15962802 0,18341213 ! myofibril assembly GO:0030239 47 30 0,000 0,15962802 0,18332459 GO:0055002|striated muscle cell development, ! determination of left/right symmetry GO:0007368 47 30 0,000 0,15962802 0,18323712 ! phospholipid transport GO:0015914 51 30 0,000 0,15962802 0,18314974 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,15962802 0,18306244 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,15962802 0,18297523 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,15962802 0,1828881 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,16448808 0,18836664 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 0,000 0,16448808 0,18827703 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,16448808 0,1881875 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,16448808 0,18809806 GO:0009799|determination of symmetry, ! inner ear morphogenesis GO:0042472 47 31 0,000 0,16448808 0,1880087 ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,16448808 0,18791943 ! ovulation cycle process GO:0022602 49 31 0,000 0,16448808 0,18783024 ! positive regulation of T cell proliferation GO:0042102 52 31 0,000 0,16448808 0,18774114 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,16448808 0,18765212 ! peptide transport GO:0015833 55 31 0,000 0,16448808 0,18756319 ! mesoderm formation GO:0001707 69 31 0,000 0,16448808 0,18747433 ! natural killer cell activation GO:0030101 45 31 0,000 0,16448808 0,18738557 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,16448808 0,18729689 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,16448808 0,18720829 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,16448808 0,18711977 ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,16448808 0,18703134 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,1693202 0,19243476 ! response to hydrogen peroxide GO:0042542 50 32 0,000 0,1693202 0,19234391 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,1693202 0,19225314 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,1693202 0,19216245 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,1693202 0,19207185 ! spliceosome assembly GO:0000245 67 32 0,000 0,1693202 0,19198134 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,1693202 0,19189091 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,1693202 0,19180056 ! response to ionizing radiation GO:0010212 65 32 0,000 0,1693202 0,1917103 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,1693202 0,19162013 ! muscle cell development GO:0055001 49 32 0,000 0,1693202 0,19153004 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,1693202 0,19144003 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,1693202 0,19135011 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,1693202 0,19126028 ! ovulation cycle GO:0042698 51 32 0,000 0,1693202 0,19117053 ! BMP signaling pathway GO:0030509 64 32 0,000 0,1693202 0,19108086 ! hindbrain development GO:0030902 61 32 0,000 0,1693202 0,19099128 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 0,000 0,1693202 0,19090178 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,1693202 0,19081236 ! post-embryonic development GO:0009791 69 33 0,000 0,17412453 0,19613465 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,17412453 0,19604287 ! ceramide metabolic process GO:0006672 64 33 0,000 0,17412453 0,19595118 ! formation of primary germ layer GO:0001704 72 33 0,000 0,17412453 0,19585957 ! cell fate specification GO:0001708 52 33 0,000 0,17412453 0,19576804 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,17412453 0,19567661 ! adult locomotory behavior GO:0008344 59 33 0,000 0,17412453 0,19558525 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,17412453 0,19549399 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 0,000 0,17890123 0,20076323 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,17890123 0,20066963 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,17890123 0,20057612 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,17890123 0,2004827 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,17890123 0,20038937 ! mismatch repair GO:0006298 46 34 0,000 0,17890123 0,20029612 ! spermatid development GO:0007286 63 34 0,000 0,17890123 0,20020296 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,17890123 0,20010988 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 0,000 0,17890123 0,2000169 ! negative regulation of secretion GO:0051048 63 35 0,000 0,18365046 0,20523131 ! negative regulation of DNA metabolic process GO:0051053 61 35 0,000 0,18365046 0,20513603 ! regulation of synaptic plasticity GO:0048167 64 35 0,000 0,18365046 0,20504084 ! odontogenesis GO:0042476 66 35 0,000 0,18365046 0,20494574 ! embryonic skeletal system morphogenesis GO:0048704 59 35 0,000 0,18365046 0,20485073 ! female gonad development GO:0008585 58 35 0,000 0,18365046 0,2047558 ! negative regulation of hydrolase activity GO:0051346 62 35 0,000 0,18365046 0,20466096 ! cytokine production GO:0001816 59 35 0,000 0,18365046 0,20456621 ! vesicle localization GO:0051648 64 35 0,000 0,18365046 0,20447155 ! mitotic sister chromatid segregation GO:0000070 57 36 0,000 0,18837238 0,2096318 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,18837238 0,20953489 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of JAK-STAT cascade GO:0046427 50 36 0,000 0,18837238 0,20943806 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,18837238 0,20934132 ! cell junction organization GO:0034330 86 36 0,000 0,18837238 0,20924467 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,18837238 0,20914811 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,18837238 0,20905164 ! positive regulation of cell development GO:0010720 80 36 0,000 0,18837238 0,20895526 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,18837238 0,20885897 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,18837238 0,20876276 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,18837238 0,20866665 ! RNA export from nucleus GO:0006405 56 37 0,000 0,19306715 0,21376878 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,19306715 0,21367045 ! meiosis I GO:0007127 65 37 0,000 0,19306715 0,21357221 ! establishment or maintenance of cell polarity GO:0007163 83 37 0,000 0,19306715 0,21347406 ! sister chromatid segregation GO:0000819 58 37 0,000 0,19306715 0,213376 ! actomyosin structure organization GO:0031032 62 37 0,000 0,19306715 0,21327804 ! organic anion transport GO:0015711 68 37 0,000 0,19306715 0,21318016 ! monovalent inorganic cation homeostasis GO:0055067 58 37 0,000 0,19306715 0,21308237 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,19306715 0,21298467 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,19306715 0,21288706 GO:0015986|ATP synthesis coupled proton transport, ! pigment metabolic process GO:0042440 80 37 0,000 0,19306715 0,21278954 ! spermatid differentiation GO:0048515 66 37 0,000 0,19306715 0,21269211 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,19773491 0,21773464 GO:0006956|complement activation, ! positive regulation of DNA metabolic process GO:0051054 72 38 0,000 0,19773491 0,21763504 ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,19773491 0,21753553 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,19773491 0,21743611 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,19773491 0,21733677 ! development of primary female sexual characteristics GO:0046545 67 38 0,000 0,19773491 0,21723753 GO:0046660|female sex differentiation, ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,19773491 0,21713838 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,19773491 0,21703932 ! mRNA catabolic process GO:0006402 71 39 0,000 0,20237583 0,22203203 ! development of primary male sexual characteristics GO:0046546 66 39 0,000 0,20237583 0,22193083 ! ion transmembrane transport GO:0034220 66 39 0,000 0,20237583 0,22182972 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,20237583 0,22172871 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,20237583 0,22162778 ! RNA modification GO:0009451 57 39 0,000 0,20237583 0,22152695 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,20237583 0,22142621 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 0,000 0,20699005 0,22637185 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,20699005 0,226269 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,20699005 0,22616624 ! feeding behavior GO:0007631 59 40 0,000 0,20699005 0,22606358 ! maintenance of protein location GO:0045185 91 40 0,000 0,20699005 0,22596101 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,21157773 0,23086441 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,21157773 0,23075976 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,21157773 0,2306552 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,21157773 0,23055074 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,21157773 0,23044637 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,21157773 0,23034209 ! female gamete generation GO:0007292 61 41 0,000 0,21157773 0,23023791 ! polyol metabolic process GO:0019751 66 41 0,000 0,21157773 0,23013383 ! dorsal/ventral pattern formation GO:0009953 68 41 0,000 0,21157773 0,23002984 ! response to reactive oxygen species GO:0000302 67 42 0,000 0,21613903 0,23488279 ! regulation of tube size GO:0035150 71 42 0,000 0,21613903 0,23477675 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,21613903 0,2346708 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 0,000 0,21613903 0,23456495 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,21613903 0,2344592 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,21613903 0,23435354 ! regulation of protein secretion GO:0050708 71 42 0,000 0,21613903 0,23424797 ! epithelial cell differentiation GO:0030855 79 43 0,000 0,22067408 0,23905531 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,22067408 0,23894773 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,22067408 0,23884024 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,22067408 0,23873284 ! striated muscle contraction GO:0006941 77 43 0,000 0,22067408 0,23862555 ! phagocytosis GO:0006909 90 43 0,000 0,22067408 0,23851835 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,22067408 0,23841125 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,22518305 0,24317344 ! male sex differentiation GO:0046661 76 44 0,000 0,22518305 0,24306434 ! double-strand break repair GO:0006302 81 44 0,000 0,22518305 0,24295535 ! biopolymer methylation GO:0043414 84 44 0,000 0,22518305 0,24284645 ! B cell differentiation GO:0030183 107 44 0,000 0,22518305 0,24273765 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,22518305 0,24262894 ! maintenance of location in cell GO:0051651 97 44 0,000 0,22518305 0,24252033 ! branching morphogenesis of a tube GO:0048754 97 45 0,000 0,22966608 0,24723785 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,22966608 0,24712728 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,22966608 0,24701681 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,22966608 0,24690643 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,22966608 0,24679616 ! cell growth GO:0016049 84 45 0,000 0,22966608 0,24668598 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,23412332 0,25136132 ! positive regulation of defense response GO:0031349 76 47 0,000 0,23855492 0,25600497 ! response to calcium ion GO:0051592 81 47 0,000 0,23855492 0,25589083 ! endosome transport GO:0016197 108 47 0,000 0,23855492 0,2557768 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,23855492 0,25566287 ! JNK cascade GO:0007254 91 47 0,000 0,23855492 0,25554904 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,23855492 0,25543531 ! methylation GO:0032259 90 47 0,000 0,23855492 0,25532168 ! mitochondrial transport GO:0006839 82 48 0,000 0,24296102 0,25992184 ! Notch signaling pathway GO:0007219 96 48 0,000 0,24296102 0,25980632 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,24296102 0,2596909 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,24296102 0,25957558 ! regulation of inflammatory response GO:0050727 75 48 0,000 0,24296102 0,25946037 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,24734177 0,26402143 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,24734177 0,26390434 ! regulation of ion transport GO:0043269 77 49 0,000 0,24734177 0,26378737 ! induction of apoptosis by extracellular signals GO:0008624 89 49 0,000 0,24734177 0,26367049 ! peptide metabolic process GO:0006518 76 49 0,000 0,24734177 0,26355372 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,24734177 0,26343705 ! DNA-dependent DNA replication GO:0006261 74 49 0,000 0,24734177 0,26332049 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,24734177 0,26320402 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,24734177 0,26308766 ! regulation of cell projection organization GO:0031344 121 50 0,000 0,25169731 0,26760218 ! neuromuscular process GO:0050905 99 50 0,000 0,25169731 0,26748398 ! regulation of ossification GO:0030278 117 50 0,000 0,25169731 0,26736589 ! inner ear development GO:0048839 79 50 0,000 0,25169731 0,2672479 ! regulation of gene expression, epigenetic GO:0040029 105 50 0,000 0,25169731 0,26713001 ! viral infectious cycle GO:0019058 99 51 0,000 0,2560278 0,27160621 ! response to estrogen stimulus GO:0043627 93 51 0,000 0,2560278 0,27148651 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,2560278 0,27136691 ! embryonic skeletal system development GO:0048706 85 51 0,000 0,2560278 0,27124742 ! excretion GO:0007588 83 51 0,000 0,2560278 0,27112803 ! chromatin remodeling GO:0006338 109 51 0,000 0,2560278 0,27100875 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 0,000 0,2560278 0,27088957 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,2560278 0,2707705 ! morphogenesis of a branching structure GO:0001763 111 52 0,000 0,26033336 0,27520302 ! amino acid activation GO:0043038 92 52 0,000 0,26033336 0,27508216 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! synapse organization GO:0050808 85 52 0,000 0,26033336 0,2749614 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,26461416 0,2793601 ! RNA catabolic process GO:0006401 93 53 0,000 0,26461416 0,27923757 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,26461416 0,27911515 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,26461416 0,27899284 ! cell maturation GO:0048469 100 53 0,000 0,26461416 0,27887064 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,26887031 0,28323204 ! cell recognition GO:0008037 85 54 0,000 0,26887031 0,28310809 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,26887031 0,28298424 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,26887031 0,28286051 ! chloride transport GO:0006821 90 55 0,000 0,27310198 0,28718678 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,27310198 0,28706132 ! gastrulation GO:0007369 112 55 0,000 0,27310198 0,28693597 ! nuclear export GO:0051168 97 55 0,000 0,27310198 0,28681072 ! sensory perception of smell GO:0007608 80 56 0,000 0,27730929 0,29110216 ! skeletal muscle fiber development GO:0048741 111 56 0,000 0,27730929 0,29097521 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,27730929 0,29084837 ! nucleotide-excision repair GO:0006289 83 56 0,000 0,27730929 0,29072164 ! proton transport GO:0015992 94 56 0,000 0,27730929 0,29059502 ! muscle fiber development GO:0048747 112 57 0,000 0,28149239 0,29485011 ! maintenance of location GO:0051235 118 57 0,000 0,28149239 0,2947218 ! hydrogen transport GO:0006818 97 58 0,000 0,28565142 0,2989462 ! adult behavior GO:0030534 99 58 0,000 0,28565142 0,29881622 ! positive regulation of secretion GO:0051047 95 59 0,000 0,28978651 0,30301014 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,28978651 0,30287852 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 97 59 0,000 0,28978651 0,302747 ! integrin-mediated signaling pathway GO:0007229 135 59 0,000 0,28978651 0,3026156 ! establishment of organelle localization GO:0051656 109 59 0,000 0,28978651 0,30248431 ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,2938978 0,30664272 ! regulation of heart contraction GO:0008016 110 60 0,000 0,2938978 0,3065098 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,29798543 0,31063819 ! mesoderm development GO:0007498 119 61 0,000 0,29798543 0,31050365 ! tRNA processing GO:0008033 89 61 0,000 0,29798543 0,31036924 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,29798543 0,31023493 ! viral reproductive process GO:0022415 126 62 0,000 0,30204952 0,31433008 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,30204952 0,31419419 ! gonad development GO:0008406 98 62 0,000 0,30204952 0,31405841 ! regulation of mitosis GO:0007088 105 63 0,000 0,30609023 0,31812228 GO:0051783|regulation of nuclear division, ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,30609023 0,31798493 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 0,000 0,31010767 0,32201945 ! cell redox homeostasis GO:0045454 102 64 0,000 0,31010767 0,32188053 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,31010767 0,32174173 ! multicellular organism reproduction GO:0032504 111 64 0,000 0,31010767 0,32160304 GO:0048609|reproductive process in a multicellular organism, ! single fertilization GO:0007338 75 64 0,000 0,31010767 0,32146448 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,31410199 0,32546486 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,31410199 0,32532475 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,31807332 0,32929621 ! actin filament organization GO:0007015 148 66 0,000 0,31807332 0,32915458 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,31807332 0,32901307 ! secondary metabolic process GO:0019748 116 66 0,000 0,31807332 0,32887168 ! regulation of cellular response to stress GO:0080135 128 67 0,000 0,32202178 0,33281117 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,32202178 0,33266827 ! activation of MAPK activity GO:0000187 115 67 0,000 0,32202178 0,33252549 ! chromosome segregation GO:0007059 113 67 0,000 0,32202178 0,33238284 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,32202178 0,33224031 ! positive regulation of T cell activation GO:0050870 109 67 0,000 0,32202178 0,3320979 ! activation of immune response GO:0002253 105 67 0,000 0,32202178 0,33195561 ! amino acid transport GO:0006865 125 68 0,000 0,32594751 0,33585855 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,32594751 0,33571477 ! viral reproduction GO:0016032 134 68 0,000 0,32594751 0,33557112 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,32594751 0,33542759 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 0,000 0,32594751 0,33528419 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,32985064 0,33915412 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 0,000 0,32985064 0,33900924 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,32985064 0,33886449 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,32985064 0,33871986 ! antigen processing and presentation GO:0019882 104 69 0,000 0,32985064 0,33857536 ! reproductive structure development GO:0048608 113 71 0,000 0,33758961 0,34637126 ! B cell activation GO:0042113 160 71 0,000 0,33758961 0,34622362 ! regulation of immune effector process GO:0002697 137 71 0,000 0,33758961 0,3460761 ! acute inflammatory response GO:0002526 113 72 0,000 0,34142571 0,34985956 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 0,000 0,34142571 0,34971062 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 0,000 0,34142571 0,34956181 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 0,000 0,34142571 0,34941312 ! regulation of blood pressure GO:0008217 125 73 0,000 0,34523972 0,35316614 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,34523972 0,35301605 ! axon guidance GO:0007411 139 73 0,000 0,34523972 0,35286608 ! fertilization GO:0009566 90 73 0,000 0,34523972 0,35271625 ! neurotransmitter transport GO:0006836 123 74 0,000 0,34903177 0,35643906 ! exocytosis GO:0006887 133 74 0,000 0,34903177 0,35628784 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,34903177 0,35613674 ! organelle localization GO:0051640 136 74 0,000 0,34903177 0,35598577 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,35280198 0,35967863 ! rhythmic process GO:0048511 128 75 0,000 0,35280198 0,35952629 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,35655048 0,3631924 ! development of primary sexual characteristics GO:0045137 124 76 0,000 0,35655048 0,3630387 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,35655048 0,36288513 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,36027739 0,36652322 ! positive regulation of ligase activity GO:0051351 124 77 0,000 0,36027739 0,3663683 ! blood coagulation GO:0007596 146 78 0,000 0,36398284 0,36998003 GO:0050817|coagulation, ! response to steroid hormone stimulus GO:0048545 137 78 0,000 0,36398284 0,36982378 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,36766695 0,37340933 ! activation of protein kinase activity GO:0032147 147 79 0,000 0,36766695 0,37325177 ! regulation of synaptic transmission GO:0050804 134 79 0,000 0,36766695 0,37309434 ! response to metal ion GO:0010038 140 80 0,000 0,37132985 0,37665245 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,37132985 0,37649372 ! inorganic anion transport GO:0015698 138 80 0,000 0,37132985 0,37633513 ! digestion GO:0007586 112 81 0,000 0,37497164 0,37986601 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,37497164 0,37970613 ! regulation of neuron differentiation GO:0045664 167 81 0,000 0,37497164 0,37954639 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,37859246 0,38305024 ! response to nutrient GO:0007584 125 82 0,000 0,37859246 0,38288922 ! hemostasis GO:0007599 158 84 0,000 0,38577165 0,38998596 ! regulation of transmission of nerve impulse GO:0051969 141 84 0,000 0,38577165 0,38982217 ! response to unfolded protein GO:0006986 131 85 0,000 0,38933026 0,39325298 ! one-carbon metabolic process GO:0006730 154 85 0,000 0,38933026 0,39308796 ! amine biosynthetic process GO:0009309 138 86 0,000 0,39286837 0,39649384 ! response to inorganic substance GO:0010035 153 86 0,000 0,39286837 0,39632759 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,39286837 0,39616149 ! amine transport GO:0015837 155 86 0,000 0,39286837 0,39599552 ! positive regulation of protein modification process GO:0031401 136 88 0,000 0,39988356 0,40289776 ! regulation of neurological system process GO:0031644 148 88 0,000 0,39988356 0,40272911 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,39988356 0,40256061 ! cellular defense response GO:0006968 114 89 0,000 0,40336088 0,40589137 ! sex differentiation GO:0007548 145 90 0,000 0,40681816 0,4091992 ! sterol metabolic process GO:0016125 152 91 0,000 0,41025552 0,41248424 ! response to protein stimulus GO:0051789 149 91 0,000 0,41025552 0,41231194 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,41025552 0,41213978 ! regulation of defense response GO:0031347 149 92 0,000 0,41367308 0,41539959 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,41367308 0,41522629 ! vitamin metabolic process GO:0006766 139 92 0,000 0,41367308 0,41505314 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 0,000 0,41707094 0,4182879 GO:0010498|proteasomal protein catabolic process, ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,42044923 0,42150035 ! female pregnancy GO:0007565 164 94 0,000 0,42044923 0,4213248 ! mRNA transport GO:0051028 169 96 0,000 0,42714751 0,42785883 ! positive regulation of immune response GO:0050778 156 96 0,000 0,42714751 0,42768078 ! hormone metabolic process GO:0042445 157 97 0,000 0,43046773 0,43082586 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,43705088 0,4372326 ! Golgi vesicle transport GO:0048193 207 99 0,000 0,43705088 0,43705088