pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1202-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! G1/S transition of mitotic cell cycle GO:0000082 87 43 9,000 4,89E-12 1,125E-08 ! interphase of mitotic cell cycle GO:0051329 156 86 10,000 3,868E-10 4,448E-07 ! interphase GO:0051325 159 88 10,000 4,981E-10 3,819E-07 ! positive regulation of cell migration GO:0030335 92 51 8,000 8,319E-10 4,783E-07 ! positive regulation of cell motion GO:0051272 99 56 8,000 1,992E-09 9,162E-07 ! apoptotic mitochondrial changes GO:0008637 29 18 5,000 9,414E-09 3,609E-06 ! peptidyl-amino acid modification GO:0018193 147 93 9,000 1,39E-08 4,566E-06 ! response to hypoxia GO:0001666 132 72 8,000 1,974E-08 5,674E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 7,000 1,977E-08 5,053E-06 ! response to oxygen levels GO:0070482 137 74 8,000 2,523E-08 5,803E-06 ! positive regulation of cell cycle GO:0045787 77 45 6,000 1,667E-07 3,486E-05 ! peptidyl-serine phosphorylation GO:0018105 23 15 4,000 1,735E-07 3,326E-05 ! response to UV GO:0009411 75 46 6,000 1,952E-07 3,453E-05 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 3,000 2,374E-07 3,9E-05 ! regulation of smooth muscle cell migration GO:0014910 19 7 3,000 2,374E-07 3,64E-05 ! peptidyl-serine modification GO:0018209 27 17 4,000 3,523E-07 5,064E-05 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 3,000 4,714E-07 6,377E-05 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 3,000 4,714E-07 6,023E-05 ! nucleus organization GO:0006997 49 33 5,000 5,01E-07 6,065E-05 ! apoptotic nuclear changes GO:0030262 24 19 4,000 6,522E-07 7,5E-05 ! positive regulation of glucose metabolic process GO:0010907 15 9 3,000 8,424E-07 9,226E-05 ! negative regulation of protein kinase activity GO:0006469 99 57 6,000 8,855E-07 9,258E-05 ! negative regulation of kinase activity GO:0033673 100 58 6,000 9,993E-07 9,993E-05 ! positive regulation of MAP kinase activity GO:0043406 121 85 7,000 1,147E-06 1,099E-04 ! regulation of B cell proliferation GO:0030888 15 10 3,000 1,394E-06 1,282E-04 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 3,000 1,394E-06 1,233E-04 ! negative regulation of transferase activity GO:0051348 105 61 6,000 1,417E-06 1,207E-04 ! negative regulation of cell size GO:0045792 108 64 6,000 1,971E-06 1,619E-04 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 3,000 2,175E-06 1,725E-04 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 3,000 2,175E-06 1,667E-04 ! T cell homeostasis GO:0043029 20 11 3,000 2,175E-06 1,613E-04 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 2,297E-06 1,651E-04 ! positive regulation of cellular catabolic process GO:0031331 22 12 3,000 3,239E-06 2,257E-04 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 3,000 3,239E-06 2,191E-04 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 26 13 3,000 4,644E-06 3,052E-04 ! lymphocyte homeostasis GO:0002260 24 13 3,000 4,644E-06 2,967E-04 ! mitochondrion organization GO:0007005 104 73 6,000 4,824E-06 2,999E-04 ! negative regulation of growth GO:0045926 123 75 6,000 5,787E-06 3,503E-04 ! positive regulation of growth GO:0045927 67 50 5,000 6,317E-06 3,726E-04 ! neuron maturation GO:0042551 21 14 3,000 6,456E-06 3,712E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 6,456E-06 3,621E-04 ! positive regulation of glycolysis GO:0045821 11 5 2,000 7,564E-06 4,142E-04 ! peptidyl-threonine phosphorylation GO:0018107 14 5 2,000 7,564E-06 4,046E-04 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 2,000 7,564E-06 3,954E-04 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 3,000 8,74E-06 4,467E-04 ! regulation of glucose metabolic process GO:0010906 22 16 3,000 1,157E-05 5,785E-04 ! androgen receptor signaling pathway GO:0030521 54 33 4,000 1,199E-05 5,87E-04 ! response to peptide hormone stimulus GO:0043434 84 57 5,000 1,368E-05 6,555E-04 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 1,396E-05 6,552E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 3,000 1,502E-05 6,91E-04 ! N-terminal protein amino acid acetylation GO:0006474 7 6 2,000 1,503E-05 6,776E-04 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 2,000 1,503E-05 6,646E-04 ! negative regulation of B cell activation GO:0050869 9 6 2,000 1,503E-05 6,52E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 1,503E-05 6,4E-04 ! gut development GO:0048565 26 18 3,000 1,917E-05 8,019E-04 ! urogenital system development GO:0001655 101 61 5,000 2,031E-05 8,34E-04 ! negative regulation of cell growth GO:0030308 106 62 5,000 2,231E-05 9,003E-04 ! positive regulation of fibroblast proliferation GO:0048146 27 19 3,000 2,411E-05 9,562E-04 ! regulation of carbohydrate metabolic process GO:0006109 28 19 3,000 2,411E-05 9,4E-04 GO:0010675|regulation of cellular carbohydrate metabolic process, ! cell structure disassembly during apoptosis GO:0006921 24 19 3,000 2,411E-05 9,244E-04 ! mesenchymal cell development GO:0014031 64 38 4,000 2,444E-05 9,216E-04 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 5,000 2,447E-05 9,079E-04 ! positive regulation of monooxygenase activity GO:0032770 11 7 2,000 2,612E-05 9,534E-04 ! peptidyl-threonine modification GO:0018210 18 7 2,000 2,612E-05 9,385E-04 ! angiogenesis GO:0001525 149 95 6,000 2,762E-05 9,774E-04 ! response to light stimulus GO:0009416 153 96 6,000 2,957E-05 1,03E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 2,993E-05 1,027E-03 ! positive regulation of locomotion GO:0040017 35 20 3,000 2,993E-05 1,012E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of response to external stimulus GO:0032103 65 40 4,000 3,157E-05 1,052E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 3,157E-05 1,037E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 3,000 3,67E-05 1,189E-03 ! regulation of chemotaxis GO:0050920 36 21 3,000 3,67E-05 1,172E-03 ! response to cytokine stimulus GO:0034097 47 21 3,000 3,67E-05 1,156E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 3,000 3,67E-05 1,141E-03 ! positive regulation of endothelial cell migration GO:0010595 18 8 2,000 4,15E-05 1,273E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 2,000 4,15E-05 1,256E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 4,454E-05 1,33E-03 ! regulation of behavior GO:0050795 38 22 3,000 4,454E-05 1,313E-03 ! leukocyte homeostasis GO:0001776 33 22 3,000 4,454E-05 1,297E-03 ! response to insulin stimulus GO:0032868 63 43 4,000 4,517E-05 1,299E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 5,000 4,855E-05 1,379E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 5,353E-05 1,501E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 5,648E-05 1,565E-03 ! tube morphogenesis GO:0035239 118 73 5,000 5,684E-05 1,556E-03 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 6,139E-05 1,661E-03 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 2,000 6,183E-05 1,654E-03 ! regulation of developmental growth GO:0048638 13 9 2,000 6,183E-05 1,635E-03 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 2,000 6,183E-05 1,616E-03 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 15 9 2,000 6,183E-05 1,598E-03 ! regulation of cellular catabolic process GO:0031329 36 24 3,000 6,378E-05 1,63E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 3,000 6,378E-05 1,612E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 3,000 6,378E-05 1,594E-03 ! regulation of ligase activity GO:0051340 114 75 5,000 6,623E-05 1,638E-03 ! regulation of chromosome organization GO:0033044 35 25 3,000 7,538E-05 1,844E-03 ! positive regulation of nuclear division GO:0051785 39 25 3,000 7,538E-05 1,825E-03 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 7,538E-05 1,806E-03 ! peptide or protein amino-terminal blocking GO:0018409 14 10 2,000 8,773E-05 2,08E-03 ! positive regulation of leukocyte migration GO:0002687 23 10 2,000 8,773E-05 2,059E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 2,000 8,773E-05 2,038E-03 GO:0043470|regulation of carbohydrate catabolic process, ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 3,000 8,845E-05 2,034E-03 ! positive regulation of organelle organization GO:0010638 82 51 4,000 1,039E-04 2,365E-03 ! positive regulation of multicellular organism growth GO:0040018 38 28 3,000 1,194E-04 2,693E-03 ! positive regulation of catabolic process GO:0009896 40 28 3,000 1,194E-04 2,667E-03 ! regulation of B cell activation GO:0050864 42 28 3,000 1,194E-04 2,641E-03 ! plasma membrane organization GO:0007009 18 11 2,000 1,198E-04 2,625E-03 ! focal adhesion formation GO:0048041 24 11 2,000 1,198E-04 2,6E-03 ! regulation of leukocyte migration GO:0002685 24 11 2,000 1,198E-04 2,576E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 1,198E-04 2,552E-03 GO:0042130|negative regulation of T cell proliferation, ! kidney development GO:0001822 90 53 4,000 1,25E-04 2,638E-03 ! cell cycle arrest GO:0007050 150 86 5,000 1,423E-04 2,975E-03 ! negative regulation of cell activation GO:0050866 44 30 3,000 1,576E-04 3,265E-03 ! regulation of skeletal muscle fiber development GO:0048742 20 12 2,000 1,587E-04 3,259E-03 ! histone acetylation GO:0016573 23 12 2,000 1,587E-04 3,23E-03 ! peptidyl-lysine modification GO:0018205 18 12 2,000 1,587E-04 3,201E-03 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 2,000 1,587E-04 3,174E-03 ! developmental maturation GO:0021700 75 57 4,000 1,771E-04 3,512E-03 ! regulation of striated muscle tissue development GO:0016202 47 31 3,000 1,796E-04 3,531E-03 ! metanephros development GO:0001656 58 31 3,000 1,796E-04 3,501E-03 ! steroid hormone receptor signaling pathway GO:0030518 96 58 4,000 1,924E-04 3,718E-03 ! regulation of muscle development GO:0048634 48 32 3,000 2,038E-04 3,906E-03 ! regulation of protein stability GO:0031647 48 32 3,000 2,038E-04 3,874E-03 ! N-terminal protein amino acid modification GO:0031365 18 13 2,000 2,049E-04 3,863E-03 ! activation of MAPK activity GO:0000187 84 59 4,000 2,087E-04 3,902E-03 ! regulation of homeostatic process GO:0032844 105 60 4,000 2,259E-04 4,191E-03 ! negative regulation of cell adhesion GO:0007162 67 33 3,000 2,303E-04 4,237E-03 ! carbohydrate homeostasis GO:0033500 39 33 3,000 2,303E-04 4,203E-03 GO:0042593|glucose homeostasis, ! homeostasis of number of cells GO:0048872 84 61 4,000 2,443E-04 4,424E-03 ! regulation of skeletal muscle tissue development GO:0048641 22 14 2,000 2,59E-04 4,654E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 2,59E-04 4,618E-03 ! negative regulation of blood coagulation GO:0030195 19 14 2,000 2,59E-04 4,582E-03 ! epithelial to mesenchymal transition GO:0001837 22 14 2,000 2,59E-04 4,547E-03 ! regulation of response to external stimulus GO:0032101 139 96 5,000 2,602E-04 4,533E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 4,000 2,638E-04 4,562E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 4,000 2,844E-04 4,882E-03 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 2,000 3,216E-04 5,479E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 3,216E-04 5,438E-03 ! positive regulation of oxidoreductase activity GO:0051353 21 15 2,000 3,216E-04 5,399E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 3,216E-04 5,36E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 3,216E-04 5,321E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 4,000 3,293E-04 5,41E-03 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 4,000 3,293E-04 5,372E-03 ! protein amino acid acetylation GO:0006473 28 16 2,000 3,931E-04 6,367E-03 ! neural crest cell migration GO:0001755 24 16 2,000 3,931E-04 6,323E-03 ! G1 phase GO:0051318 27 16 2,000 3,931E-04 6,279E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 3,931E-04 6,236E-03 ! negative regulation of translation GO:0017148 22 16 2,000 3,931E-04 6,193E-03 ! pigmentation GO:0043473 74 38 3,000 4,008E-04 6,271E-03 ! positive regulation of ligase activity GO:0051351 99 69 4,000 4,35E-04 6,761E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 4,65E-04 7,179E-03 ! regulation of viral genome replication GO:0045069 24 17 2,000 4,741E-04 7,27E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 4,741E-04 7,222E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 4,741E-04 7,174E-03 ! negative regulation of coagulation GO:0050819 23 17 2,000 4,741E-04 7,128E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 5,297E-04 7,912E-03 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of DNA replication GO:0045740 29 18 2,000 5,651E-04 8,386E-03 ! negative regulation of T cell activation GO:0050868 25 18 2,000 5,651E-04 8,332E-03 ! cellular component disassembly GO:0022411 64 42 3,000 5,906E-04 8,652E-03 ! branching morphogenesis of a tube GO:0048754 72 42 3,000 5,906E-04 8,597E-03 ! epithelial tube morphogenesis GO:0060562 65 43 3,000 6,465E-04 9,352E-03 ! response to alkaloid GO:0043279 32 19 2,000 6,666E-04 9,582E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 6,666E-04 9,522E-03 ! sex determination GO:0007530 29 19 2,000 6,666E-04 9,464E-03 ! regulation of endothelial cell migration GO:0010594 40 19 2,000 6,666E-04 9,406E-03 ! renal system process GO:0003014 35 19 2,000 6,666E-04 9,348E-03 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 6,666E-04 9,292E-03 ! negative regulation of cell migration GO:0030336 92 44 3,000 7,061E-04 9,784E-03 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 7,061E-04 9,725E-03 ! cell maturation GO:0048469 60 45 3,000 7,695E-04 0,01053485 ! negative regulation of bone resorption GO:0045779 10 5 1,000 8,277E-04 0,01126446 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 8,277E-04 0,0111982 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 8,277E-04 0,01113271 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 8,277E-04 0,01106799 ! positive regulation of histone modification GO:0031058 5 5 1,000 8,277E-04 0,01100401 ! embryonic hemopoiesis GO:0035162 10 5 1,000 8,277E-04 0,01094077 ! anagen GO:0042640 6 5 1,000 8,277E-04 0,01087825 ! positive regulation of viral genome replication GO:0045070 8 5 1,000 8,277E-04 0,01081644 ! epithelial cell proliferation GO:0050673 6 5 1,000 8,277E-04 0,01075533 ! regulation of retroviral genome replication GO:0045091 6 5 1,000 8,277E-04 0,01069491 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 8,277E-04 0,01063516 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 8,277E-04 0,01057608 ! valine metabolic process GO:0006573 8 5 1,000 8,277E-04 0,01051765 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 1,000 8,277E-04 0,01045986 ! nerve growth factor processing GO:0032455 7 5 1,000 8,277E-04 0,0104027 ! response to food GO:0032094 5 5 1,000 8,277E-04 0,01034616 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 8,277E-04 0,01029024 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 1,000 8,277E-04 0,01023492 ! neuronal ion channel clustering GO:0045161 7 5 1,000 8,277E-04 0,01018018 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 8,277E-04 0,01012603 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 8,277E-04 0,01007246 GO:0045686|negative regulation of glial cell differentiation, ! positive regulation of chemokine production GO:0032722 7 5 1,000 8,277E-04 0,01001944 ! enteric nervous system development GO:0048484 8 5 1,000 8,277E-04 9,967E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 8,277E-04 9,915E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 8,277E-04 9,864E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 8,277E-04 9,813E-03 ! protein amino acid acylation GO:0043543 37 21 2,000 9,026E-04 0,01064629 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 9,026E-04 0,01059197 ! response to glucocorticoid stimulus GO:0051384 33 21 2,000 9,026E-04 0,01053821 ! regulation of cell cycle process GO:0010564 122 81 4,000 9,078E-04 0,01054508 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 9,081E-04 0,01049608 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of cell adhesion GO:0030155 159 83 4,000 1,014E-03 0,01165725 ! molting cycle process GO:0022404 40 22 2,000 1,038E-03 0,01187883 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! vasculogenesis GO:0001570 33 22 2,000 1,038E-03 0,01182003 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 1,038E-03 0,0117618 GO:0010810|regulation of cell-substrate adhesion, ! ureteric bud development GO:0001657 32 22 2,000 1,038E-03 0,01170414 ! regulation of blood coagulation GO:0030193 34 22 2,000 1,038E-03 0,01164705 ! morphogenesis of a branching structure GO:0001763 86 49 3,000 1,063E-03 0,0118739 ! germ cell development GO:0007281 68 49 3,000 1,063E-03 0,01181654 ! negative regulation of multicellular organismal process GO:0051241 133 85 4,000 1,128E-03 0,01247817 ! regulation of multicellular organism growth GO:0040014 65 50 3,000 1,148E-03 0,01263083 ! cellular iron ion homeostasis GO:0006879 37 23 2,000 1,186E-03 0,01298726 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 1,186E-03 0,01292571 ! response to corticosteroid stimulus GO:0031960 36 23 2,000 1,186E-03 0,01286474 ! regulation of viral reproduction GO:0050792 32 23 2,000 1,186E-03 0,01280434 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 1,186E-03 0,0127445 ! prostate gland development GO:0030850 9 6 1,000 1,234E-03 0,01320122 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,234E-03 0,0131401 ! signal peptide processing GO:0006465 8 6 1,000 1,234E-03 0,01307955 ! mRNA stabilization GO:0048255 15 6 1,000 1,234E-03 0,01301955 GO:0043489|RNA stabilization, ! pigment granule organization GO:0048753 11 6 1,000 1,234E-03 0,0129601 ! ER overload response GO:0006983 7 6 1,000 1,234E-03 0,01290119 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,234E-03 0,01284282 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 1,234E-03 0,01278497 ! maintenance of protein location in nucleus GO:0051457 16 6 1,000 1,234E-03 0,01272764 ! neuron apoptosis GO:0051402 8 6 1,000 1,234E-03 0,01267082 ! male sex determination GO:0030238 9 6 1,000 1,234E-03 0,0126145 ! negative regulation of translational initiation GO:0045947 7 6 1,000 1,234E-03 0,01255868 ! macrophage differentiation GO:0030225 10 6 1,000 1,234E-03 0,01250336 ! DNA topological change GO:0006265 8 6 1,000 1,234E-03 0,01244852 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 1,234E-03 0,01239416 ! gas homeostasis GO:0033483 11 6 1,000 1,234E-03 0,01234027 ! hair follicle maturation GO:0048820 7 6 1,000 1,234E-03 0,01228685 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,234E-03 0,01223389 ! negative regulation of cell motion GO:0051271 104 51 3,000 1,237E-03 0,01220677 ! fat cell differentiation GO:0045444 37 24 2,000 1,346E-03 0,01323071 ! neural crest cell development GO:0014032 39 24 2,000 1,346E-03 0,01317441 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 2,000 1,346E-03 0,01311859 ! reproductive developmental process GO:0003006 127 89 4,000 1,387E-03 0,01345617 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 1,519E-03 0,01468287 GO:0045936|negative regulation of phosphate metabolic process, ! male gonad development GO:0008584 33 25 2,000 1,519E-03 0,01462144 ! iron ion homeostasis GO:0055072 39 25 2,000 1,519E-03 0,01456052 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,519E-03 0,0145001 ! regulation of mitosis GO:0007088 84 54 3,000 1,532E-03 0,01455899 GO:0051783|regulation of nuclear division, ! DNA catabolic process GO:0006308 67 54 3,000 1,532E-03 0,01449908 ! regulation of coagulation GO:0050818 39 26 2,000 1,706E-03 0,01608113 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 1,717E-03 0,01612058 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,717E-03 0,01605505 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,717E-03 0,01599005 ! regulation of gluconeogenesis GO:0006111 7 7 1,000 1,717E-03 0,01592557 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,717E-03 0,01586161 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 1,000 1,717E-03 0,01579816 ! microtubule bundle formation GO:0001578 8 7 1,000 1,717E-03 0,01573522 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,717E-03 0,01567278 ! hemoglobin metabolic process GO:0020027 10 7 1,000 1,717E-03 0,01561083 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 1,717E-03 0,01554937 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,717E-03 0,0154884 ! organ growth GO:0035265 11 7 1,000 1,717E-03 0,0154279 ! behavioral fear response GO:0001662 13 7 1,000 1,717E-03 0,01536786 GO:0002209|behavioral defense response, ! protein heterooligomerization GO:0051291 10 7 1,000 1,717E-03 0,0153083 ! response to UV-B GO:0010224 11 7 1,000 1,717E-03 0,01524919 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,717E-03 0,01519054 ! fibrinolysis GO:0042730 9 7 1,000 1,717E-03 0,01513234 ! B cell lineage commitment GO:0002326 17 7 1,000 1,717E-03 0,01507458 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 1,717E-03 0,01501727 ! T cell lineage commitment GO:0002360 12 7 1,000 1,717E-03 0,01496038 ! neuroblast proliferation GO:0007405 13 7 1,000 1,717E-03 0,01490393 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 1,000 1,717E-03 0,0148479 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptogenesis GO:0051963 10 7 1,000 1,717E-03 0,01479229 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,717E-03 0,01473709 ! regulation of lipid metabolic process GO:0019216 84 56 3,000 1,754E-03 0,01499658 ! chromosome segregation GO:0007059 83 57 3,000 1,873E-03 0,0159548 ! response to ionizing radiation GO:0010212 47 27 2,000 1,906E-03 0,01617945 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 1,906E-03 0,01611997 ! in utero embryonic development GO:0001701 147 96 4,000 1,939E-03 0,01634008 ! cell junction assembly GO:0034329 56 28 2,000 2,121E-03 0,01780229 ! placenta development GO:0001890 37 28 2,000 2,121E-03 0,01773756 ! actin filament organization GO:0007015 95 59 3,000 2,128E-03 0,01772946 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 2,276E-03 0,01889616 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,276E-03 0,01882819 ! induction of positive chemotaxis GO:0050930 14 8 1,000 2,276E-03 0,0187607 ! succinate metabolic process GO:0006105 14 8 1,000 2,276E-03 0,0186937 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 2,276E-03 0,01862718 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 2,276E-03 0,01856112 ! middle ear morphogenesis GO:0042474 9 8 1,000 2,276E-03 0,01849554 ! melanin metabolic process GO:0006582 12 8 1,000 2,276E-03 0,01843041 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,276E-03 0,01836574 ! regulation of gliogenesis GO:0014013 20 8 1,000 2,276E-03 0,01830153 GO:0045685|regulation of glial cell differentiation, ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 2,276E-03 0,01823776 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 2,276E-03 0,01817443 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 2,276E-03 0,01811154 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 2,276E-03 0,01804909 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 2,276E-03 0,01798707 ! regulation of telomere maintenance GO:0032204 10 8 1,000 2,276E-03 0,01792547 ! regulation of embryonic development GO:0045995 16 8 1,000 2,276E-03 0,01786429 ! cell-matrix adhesion GO:0007160 114 61 3,000 2,405E-03 0,01881503 ! negative regulation of ligase activity GO:0051352 91 61 3,000 2,405E-03 0,01875125 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 3,000 2,405E-03 0,0186879 ! respiratory tube development GO:0030323 99 62 3,000 2,553E-03 0,01976858 ! embryonic epithelial tube formation GO:0001838 44 30 2,000 2,593E-03 0,02001461 ! response to heat GO:0009408 41 30 2,000 2,593E-03 0,01994767 ! cell cycle checkpoint GO:0000075 108 64 3,000 2,867E-03 0,02197672 ! appendage morphogenesis GO:0035107 93 64 3,000 2,867E-03 0,0219037 GO:0035108|limb morphogenesis, ! regulation of activated T cell proliferation GO:0046006 15 9 1,000 2,908E-03 0,02214934 ! regulation of histone modification GO:0031056 11 9 1,000 2,908E-03 0,02207624 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 1,000 2,908E-03 0,02200362 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 1,000 2,908E-03 0,02193148 ! lung alveolus development GO:0048286 17 9 1,000 2,908E-03 0,0218598 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 2,908E-03 0,0217886 ! ventral spinal cord development GO:0021517 11 9 1,000 2,908E-03 0,02171786 ! T cell selection GO:0045058 18 9 1,000 2,908E-03 0,02164757 ! phosphagen metabolic process GO:0006599 12 9 1,000 2,908E-03 0,02157774 GO:0006600|creatine metabolic process, ! substrate-bound cell migration GO:0006929 10 9 1,000 2,908E-03 0,02150836 ! receptor clustering GO:0043113 15 9 1,000 2,908E-03 0,02143942 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 2,908E-03 0,02137093 ! DNA ligation GO:0006266 14 9 1,000 2,908E-03 0,02130287 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 2,908E-03 0,02123524 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 2,908E-03 0,02116804 ! oocyte differentiation GO:0009994 12 9 1,000 2,908E-03 0,02110126 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 2,908E-03 0,02103491 ! spleen development GO:0048536 15 9 1,000 2,908E-03 0,02096897 ! embryonic placenta development GO:0001892 12 9 1,000 2,908E-03 0,02090344 ! response to nicotine GO:0035094 16 9 1,000 2,908E-03 0,02083832 ! regulation of synapse organization GO:0050807 12 9 1,000 2,908E-03 0,0207736 ! localization within membrane GO:0051668 15 9 1,000 2,908E-03 0,02070929 ! reproductive structure development GO:0048608 90 65 3,000 3,033E-03 0,02152987 ! appendage development GO:0048736 94 65 3,000 3,033E-03 0,02146362 GO:0060173|limb development, ! cytokine production GO:0001816 44 32 2,000 3,126E-03 0,02205267 ! cell-substrate adhesion GO:0031589 121 66 3,000 3,206E-03 0,02254813 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 3,415E-03 0,02394856 ! cell junction organization GO:0034330 63 33 2,000 3,415E-03 0,02387576 ! negative regulation of muscle development GO:0048635 12 10 1,000 3,613E-03 0,02518463 ! neuron fate specification GO:0048665 11 10 1,000 3,613E-03 0,02510854 ! hair follicle morphogenesis GO:0031069 17 10 1,000 3,613E-03 0,02503291 ! hippocampus development GO:0021766 19 10 1,000 3,613E-03 0,02495774 ! blood vessel remodeling GO:0001974 21 10 1,000 3,613E-03 0,02488302 ! positive regulation of lipid metabolic process GO:0045834 12 10 1,000 3,613E-03 0,02480874 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 3,613E-03 0,0247349 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 3,613E-03 0,02466151 ! glucan biosynthetic process GO:0009250 13 10 1,000 3,613E-03 0,02458854 GO:0005978|glycogen biosynthetic process, ! B cell proliferation GO:0042100 14 10 1,000 3,613E-03 0,02451601 ! fear response GO:0042596 16 10 1,000 3,613E-03 0,0244439 ! negative regulation of ossification GO:0030279 19 10 1,000 3,613E-03 0,02437222 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 3,613E-03 0,02430096 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 3,613E-03 0,02423011 ! regulation of bone resorption GO:0045124 24 10 1,000 3,613E-03 0,02415967 ! alpha-beta T cell activation GO:0046631 16 10 1,000 3,613E-03 0,02408965 ! positive regulation of viral reproduction GO:0048524 15 10 1,000 3,613E-03 0,02402002 ! embryonic gut development GO:0048566 11 10 1,000 3,613E-03 0,0239508 ! regulation of synapse structure and activity GO:0050803 13 10 1,000 3,613E-03 0,02388198 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 3,721E-03 0,02452043 ! development of primary male sexual characteristics GO:0046546 44 34 2,000 3,721E-03 0,02445037 ! neuron migration GO:0001764 46 34 2,000 3,721E-03 0,02438071 ! embryonic organ development GO:0048568 45 34 2,000 3,721E-03 0,02431145 ! regulation of catabolic process GO:0009894 106 70 3,000 3,964E-03 0,02583 ! glycogen metabolic process GO:0005977 48 35 2,000 4,042E-03 0,0262635 ! tissue remodeling GO:0048771 62 36 2,000 4,38E-03 0,0283793 ! glucan metabolic process GO:0044042 49 36 2,000 4,38E-03 0,02829959 GO:0006073|cellular glucan metabolic process, ! virus-host interaction GO:0019048 17 11 1,000 4,39E-03 0,02828168 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 4,39E-03 0,02820268 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 1,000 4,39E-03 0,02812412 ! regulation of mRNA processing GO:0050684 18 11 1,000 4,39E-03 0,028046 ! membrane protein proteolysis GO:0033619 18 11 1,000 4,39E-03 0,02796831 GO:0006509|membrane protein ectodomain proteolysis, ! temperature homeostasis GO:0001659 16 11 1,000 4,39E-03 0,02789105 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 4,39E-03 0,02781421 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 1,000 4,39E-03 0,0277378 ! digestive tract morphogenesis GO:0048546 15 11 1,000 4,39E-03 0,02766181 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of T cell proliferation GO:0042129 58 38 2,000 5,106E-03 0,03208947 ! cartilage condensation GO:0001502 18 12 1,000 5,236E-03 0,03281438 ! cytokine biosynthetic process GO:0042089 16 12 1,000 5,236E-03 0,03272521 ! heart looping GO:0001947 15 12 1,000 5,236E-03 0,03263653 ! positive regulation of cell growth GO:0030307 16 12 1,000 5,236E-03 0,03254832 ! Golgi organization GO:0007030 18 12 1,000 5,236E-03 0,03246059 ! autonomic nervous system development GO:0048483 23 12 1,000 5,236E-03 0,03237333 ! gland morphogenesis GO:0022612 23 12 1,000 5,236E-03 0,03228654 ! response to gamma radiation GO:0010332 20 12 1,000 5,236E-03 0,03220021 ! regulation of mRNA stability GO:0043488 27 12 1,000 5,236E-03 0,03211434 ! regulation of fatty acid oxidation GO:0046320 18 12 1,000 5,236E-03 0,03202893 ! morphogenesis of embryonic epithelium GO:0016331 60 39 2,000 5,495E-03 0,03352385 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 5,495E-03 0,03343516 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 5,495E-03 0,03334694 ! male sex differentiation GO:0046661 53 39 2,000 5,495E-03 0,03325919 ! developmental growth GO:0048589 62 39 2,000 5,495E-03 0,03317189 ! cell growth GO:0016049 61 39 2,000 5,495E-03 0,03308506 ! sex differentiation GO:0007548 105 77 3,000 5,568E-03 0,03343917 ! positive regulation of protein modification process GO:0031401 107 78 3,000 5,828E-03 0,03490732 ! peptide metabolic process GO:0006518 56 40 2,000 5,901E-03 0,03525199 ! T cell differentiation GO:0030217 65 40 2,000 5,901E-03 0,03516066 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 5,901E-03 0,0350698 ! regulation of chemokine production GO:0032642 17 13 1,000 6,151E-03 0,03646085 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 6,151E-03 0,03636712 ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 6,151E-03 0,03627388 ! cytokine metabolic process GO:0042107 17 13 1,000 6,151E-03 0,0361811 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 6,151E-03 0,0360888 ! cellular pigmentation GO:0033059 24 13 1,000 6,151E-03 0,03599698 ! regulation of RNA stability GO:0043487 28 13 1,000 6,151E-03 0,03590561 ! energy reserve metabolic process GO:0006112 59 41 2,000 6,324E-03 0,03682473 ! glucose transport GO:0015758 52 41 2,000 6,324E-03 0,03673174 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 3,000 6,371E-03 0,03691166 GO:0010498|proteasomal protein catabolic process, ! hexose transport GO:0008645 54 42 2,000 6,765E-03 0,03909594 GO:0015749|monosaccharide transport, ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 7,133E-03 0,04111611 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 7,133E-03 0,04101332 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 7,133E-03 0,04091104 ! cardiac muscle contraction GO:0060048 23 14 1,000 7,133E-03 0,04080927 ! limbic system development GO:0021761 25 14 1,000 7,133E-03 0,04070801 ! activation of MAPKK activity GO:0000186 21 14 1,000 7,133E-03 0,04060724 ! epidermis morphogenesis GO:0048730 29 14 1,000 7,133E-03 0,04050698 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 7,133E-03 0,04040721 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 7,133E-03 0,04030793 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 1,000 7,133E-03 0,04020913 ! G1/S transition checkpoint GO:0031575 33 14 1,000 7,133E-03 0,04011082 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 7,133E-03 0,04001299 ! mRNA splice site selection GO:0006376 26 14 1,000 7,133E-03 0,03991564 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 7,133E-03 0,03981875 ! muscle maintenance GO:0046716 19 14 1,000 7,133E-03 0,03972234 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 7,224E-03 0,04013448 ! activation of caspase activity GO:0006919 65 43 2,000 7,224E-03 0,04003777 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 7,874E-03 0,04353364 ! anterior/posterior pattern formation GO:0009952 124 85 3,000 7,874E-03 0,04342924 ! regulation of protein localization GO:0032880 132 85 3,000 7,874E-03 0,04332535 ! positive regulation of cell size GO:0045793 20 15 1,000 8,181E-03 0,04490557 ! metencephalon development GO:0022037 19 15 1,000 8,181E-03 0,04479865 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 8,181E-03 0,04469224 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 8,181E-03 0,04458634 ! lipid phosphorylation GO:0046834 23 15 1,000 8,181E-03 0,04448093 ! positive regulation of proteolysis GO:0045862 19 15 1,000 8,181E-03 0,04437602 ! peptide biosynthetic process GO:0043043 19 15 1,000 8,181E-03 0,04427161 ! defense response to virus GO:0051607 27 15 1,000 8,181E-03 0,04416769 ! peptide hormone processing GO:0016486 19 15 1,000 8,181E-03 0,04406425 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 8,181E-03 0,04396129 ! histone modification GO:0016570 68 46 2,000 8,71E-03 0,0466954 ! covalent chromatin modification GO:0016569 75 47 2,000 9,242E-03 0,04943198 ! negative regulation of immune system process GO:0002683 73 47 2,000 9,242E-03 0,04931729 ! protein secretion GO:0009306 27 16 1,000 9,293E-03 0,04947728 ! patterning of blood vessels GO:0001569 24 16 1,000 9,293E-03 0,04936302 ! cellular response to unfolded protein GO:0034620 19 16 1,000 9,293E-03 0,04924928 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of protein binding GO:0043393 27 16 1,000 9,293E-03 0,04913606 ! oogenesis GO:0048477 23 16 1,000 9,293E-03 0,04902336 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 9,293E-03 0,04891118 ! leukocyte differentiation GO:0002521 143 90 3,000 9,593E-03 0,05037192 ! positive regulation of caspase activity GO:0043280 72 48 2,000 9,792E-03 0,0513029 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 2,000 9,792E-03 0,05118631 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 9,792E-03 0,05107024 ! heart morphogenesis GO:0003007 65 48 2,000 9,792E-03 0,05095469 ! regulation of DNA replication GO:0006275 75 48 2,000 9,792E-03 0,05083967 ! cell fate commitment GO:0045165 141 92 3,000 0,01034305 0,05357887 ! regulation of angiogenesis GO:0045765 94 49 2,000 0,01036142 0,05355343 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 0,01036142 0,05343335 ! cartilage development GO:0051216 70 49 2,000 0,01036142 0,05331382 ! signal complex assembly GO:0007172 29 17 1,000 0,01046899 0,05374705 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 0,01046899 0,05362734 ! forelimb morphogenesis GO:0035136 19 17 1,000 0,01046899 0,05350817 ! actin filament bundle formation GO:0051017 26 17 1,000 0,01046899 0,05338953 ! neuromuscular junction development GO:0007528 23 17 1,000 0,01046899 0,05327141 ! proximal/distal pattern formation GO:0009954 25 17 1,000 0,01046899 0,05315381 ! ear development GO:0043583 72 50 2,000 0,01094953 0,05547119 ! regulation of binding GO:0051098 151 95 3,000 0,01153842 0,05832606 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 0,01170697 0,05904833 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 1,000 0,01170697 0,05891912 GO:0050886|endocrine process, ! pigmentation during development GO:0048066 31 18 1,000 0,01170697 0,05879047 ! heart process GO:0003015 27 18 1,000 0,01170697 0,05866239 GO:0060047|heart contraction, ! somitogenesis GO:0001756 24 18 1,000 0,01170697 0,05853486 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 0,01170697 0,05840789 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 0,01170697 0,05828146 ! aging GO:0007568 79 52 2,000 0,0121827 0,0605188 ! skeletal system morphogenesis GO:0048705 78 53 2,000 0,01282795 0,06358681 ! regulation of bone remodeling GO:0046850 90 53 2,000 0,01282795 0,06345007 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,01300584 0,06419193 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 0,01300584 0,06405447 ! regeneration GO:0031099 32 19 1,000 0,01300584 0,06391761 ! response to starvation GO:0042594 30 19 1,000 0,01300584 0,06378132 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 0,01300584 0,06364562 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 0,01300584 0,06351049 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 0,01300584 0,06337593 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 0,01300584 0,06324194 ! protein stabilization GO:0050821 26 19 1,000 0,01300584 0,06310852 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 0,01326552 0,06423306 ! regulation of tissue remodeling GO:0034103 91 54 2,000 0,01349242 0,06519449 ! regulation of translation GO:0006417 151 100 3,000 0,0137216 0,06616283 ! hindlimb morphogenesis GO:0035137 32 20 1,000 0,01436439 0,06911736 ! spinal cord development GO:0021510 31 20 1,000 0,01436439 0,06897307 ! response to ethanol GO:0045471 37 20 1,000 0,01436439 0,06882937 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01436439 0,06868627 ! chromosome condensation GO:0030261 31 20 1,000 0,01436439 0,06854377 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 0,01436439 0,06840186 ! pallium development GO:0021543 38 20 1,000 0,01436439 0,06826053 ! positive regulation of inflammatory response GO:0050729 30 20 1,000 0,01436439 0,06811979 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01436439 0,06797963 ! carbohydrate transport GO:0008643 74 57 2,000 0,01560193 0,07368466 ! secondary metabolic process GO:0019748 84 57 2,000 0,01560193 0,07353366 ! gonad development GO:0008406 79 57 2,000 0,01560193 0,07338329 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01578142 0,07407605 ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 0,01578142 0,07392518 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01578142 0,07377493 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 0,01578142 0,07362528 ! dendrite development GO:0016358 35 21 1,000 0,01578142 0,07347624 ! ovarian follicle development GO:0001541 30 21 1,000 0,01578142 0,07332781 ! cell aging GO:0007569 32 21 1,000 0,01578142 0,07317997 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01578142 0,07303272 ! viral reproductive process GO:0022415 87 58 2,000 0,01634399 0,07548428 ! lung development GO:0030324 94 59 2,000 0,01710558 0,07884337 ! myeloid cell differentiation GO:0030099 85 59 2,000 0,01710558 0,07868568 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01725575 0,07921802 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01725575 0,07906021 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01725575 0,07890303 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01725575 0,07874648 ! neural tube closure GO:0001843 33 22 1,000 0,01725575 0,07859055 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! protein tetramerization GO:0051262 39 22 1,000 0,01725575 0,07843523 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 0,01788675 0,08114306 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 2,000 0,01788675 0,08098333 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01878622 0,08488863 ! neuron fate commitment GO:0048663 32 23 1,000 0,01878622 0,08472218 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,01878622 0,08455638 ! interaction with host GO:0051701 37 23 1,000 0,01878622 0,08439123 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01878622 0,08422673 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01878622 0,08406286 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 1,000 0,01878622 0,08389963 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,02034802 0,09069852 GO:0090046|regulation of transcription regulator activity, ! viral reproduction GO:0016032 92 63 2,000 0,02034802 0,09052309 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,02037169 0,09045345 ! receptor metabolic process GO:0043112 37 24 1,000 0,02037169 0,09027916 ! primary neural tube formation GO:0014020 35 24 1,000 0,02037169 0,09010555 ! negative regulation of cell development GO:0010721 56 24 1,000 0,02037169 0,0899326 GO:0050768|negative regulation of neurogenesis, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,02037169 0,08976032 ! glutathione metabolic process GO:0006749 29 24 1,000 0,02037169 0,08958869 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 0,02037169 0,08941772 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 0,02120776 0,09291019 ! respiratory system development GO:0060541 100 64 2,000 0,02120776 0,09273356 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,02201102 0,09606329 ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 0,02201102 0,09588135 ! leukocyte proliferation GO:0070661 39 25 1,000 0,02201102 0,0957001 GO:0032943|mononuclear cell proliferation, ! regulation of caspase activity GO:0043281 97 65 2,000 0,02208719 0,09585007 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,02370311 0,10266883 ! post-embryonic development GO:0009791 42 26 1,000 0,02370311 0,10247584 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,02370311 0,10228358 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,02390511 0,10296207 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,02390511 0,10276962 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,02484359 0,10660495 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,02544685 0,10899022 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,02544685 0,10878764 ! activation of protein kinase activity GO:0032147 102 69 2,000 0,02580173 0,11010016 ! response to drug GO:0042493 108 69 2,000 0,02580173 0,10989627 ! eye development GO:0001654 111 70 2,000 0,02677953 0,11385011 ! response to metal ion GO:0010038 103 70 2,000 0,02677953 0,11364006 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,02724116 0,11538613 ! cholesterol homeostasis GO:0042632 46 28 1,000 0,02724116 0,11517402 GO:0055092|sterol homeostasis, ! erythrocyte differentiation GO:0030218 38 28 1,000 0,02724116 0,11496269 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,02724116 0,11475214 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,02724116 0,11454235 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 0,02724116 0,11433334 ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,02724116 0,11412508 ! neural tube formation GO:0001841 41 28 1,000 0,02724116 0,11391758 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,02777695 0,11594732 ! regulation of peptidase activity GO:0052547 106 72 2,000 0,02879396 0,11997484 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,02879396 0,11975788 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,02908498 0,1207499 ! ovulation cycle process GO:0022602 41 29 1,000 0,02908498 0,12053234 ! telencephalon development GO:0021537 52 29 1,000 0,02908498 0,12031555 ! tissue homeostasis GO:0001894 42 29 1,000 0,02908498 0,12009954 GO:0048871|multicellular organismal homeostasis, ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,02983054 0,12295743 ! collagen metabolic process GO:0032963 40 30 1,000 0,03097725 0,12745558 ! spliceosome assembly GO:0000245 49 30 1,000 0,03097725 0,12722798 ! spindle organization GO:0007051 37 30 1,000 0,03097725 0,12700119 ! ovulation cycle GO:0042698 43 30 1,000 0,03097725 0,12677521 ! hindbrain development GO:0030902 45 30 1,000 0,03097725 0,12655003 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,03097725 0,12632565 ! blood coagulation GO:0007596 116 75 2,000 0,03196224 0,13011177 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 2,000 0,03196224 0,12988189 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,03291693 0,13352548 ! negative regulation of secretion GO:0051048 49 31 1,000 0,03291693 0,1332904 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,03291693 0,13305614 ! segmentation GO:0035282 41 31 1,000 0,03291693 0,13282271 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,03291693 0,1325901 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,03291693 0,1323583 ! cell fate specification GO:0001708 37 31 1,000 0,03291693 0,1321273 ! regulation of protein transport GO:0051223 114 76 2,000 0,03305727 0,13245943 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 2,000 0,03417168 0,13668673 ! gland development GO:0048732 148 77 2,000 0,03417168 0,13644943 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,03490301 0,13912813 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,03490301 0,13888742 ! meiosis I GO:0007127 52 32 1,000 0,03490301 0,13864755 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,03490301 0,1384085 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,03490301 0,13817028 ! T cell activation GO:0042110 134 79 2,000 0,03645845 0,14407978 ! sister chromatid segregation GO:0000819 46 33 1,000 0,03693448 0,14571064 ! ear morphogenesis GO:0042471 42 33 1,000 0,03693448 0,14546114 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,03693448 0,14521249 ! female gonad development GO:0008585 49 33 1,000 0,03693448 0,14496468 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,03693448 0,14471773 ! positive regulation of cell development GO:0010720 54 33 1,000 0,03693448 0,14447161 ! lipid homeostasis GO:0055088 55 33 1,000 0,03693448 0,14422632 ! regulation of proteolysis GO:0030162 50 33 1,000 0,03693448 0,14398187 ! cytokinesis GO:0000910 52 33 1,000 0,03693448 0,14373825 ! protein localization in nucleus GO:0034504 133 80 2,000 0,03763068 0,14620026 ! forebrain development GO:0030900 131 80 2,000 0,03763068 0,14595372 ! hemostasis GO:0007599 125 81 2,000 0,03882205 0,15032105 ! response to protein stimulus GO:0051789 111 81 2,000 0,03882205 0,15006841 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,03901034 0,15054326 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,03901034 0,1502911 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,03901034 0,15003977 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,03901034 0,14978929 ! female gamete generation GO:0007292 43 34 1,000 0,03901034 0,14953964 ! ossification GO:0001503 134 82 2,000 0,04003248 0,15320252 GO:0060348|bone development, ! Notch signaling pathway GO:0007219 56 35 1,000 0,04112962 0,15713973 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,04112962 0,15687914 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,04112962 0,1566194 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,04112962 0,15636053 ! maintenance of protein location GO:0045185 65 35 1,000 0,04112962 0,15610251 ! pigment metabolic process GO:0042440 61 35 1,000 0,04112962 0,15584534 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,04112962 0,15558901 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,04251027 0,16054781 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,04329134 0,16322965 GO:0046660|female sex differentiation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,04329134 0,1629625 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,04329134 0,16269622 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,04329134 0,16243081 ! negative regulation of binding GO:0051100 58 36 1,000 0,04329134 0,16216627 ! neural tube development GO:0021915 50 36 1,000 0,04329134 0,16190258 ! transcription initiation GO:0006352 118 85 2,000 0,04377745 0,16345477 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04521207 0,16853771 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04521207 0,16826499 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04521207 0,16799316 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04521207 0,1677222 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04521207 0,16745212 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04521207 0,1671829 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04521207 0,16691455 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04521207 0,16664706 ! sleep GO:0030431 11 5 0,000 0,04521207 0,16638042 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04521207 0,16611464 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04521207 0,1658497 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04521207 0,16558561 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04521207 0,16532236 ! tongue development GO:0043586 6 5 0,000 0,04521207 0,16505994 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04521207 0,16479836 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04521207 0,1645376 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04521207 0,16427767 ! cobalt ion transport GO:0006824 9 5 0,000 0,04521207 0,16401856 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04521207 0,16376026 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04521207 0,16350277 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04521207 0,1632461 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04521207 0,16299023 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04521207 0,16273516 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04521207 0,16248088 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04521207 0,1622274 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04521207 0,16197471 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04521207 0,16172281 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04521207 0,16147168 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04521207 0,16122134 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04521207 0,16097177 ! malate metabolic process GO:0006108 7 5 0,000 0,04521207 0,16072297 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04521207 0,16047495 ! behavioral response to pain GO:0048266 7 5 0,000 0,04521207 0,16022768 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04521207 0,15998118 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04521207 0,15973543 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04521207 0,15949044 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04521207 0,15924619 ! mating behavior GO:0007617 6 5 0,000 0,04521207 0,1590027 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04521207 0,15875995 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04521207 0,15851793 ! rhythmic behavior GO:0007622 12 5 0,000 0,04521207 0,15827666 ! copulation GO:0007620 7 5 0,000 0,04521207 0,15803612 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04521207 0,1577963 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04521207 0,15755722 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04521207 0,15731886 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04521207 0,15708122 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04521207 0,15684429 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04521207 0,15660808 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04521207 0,15637258 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04521207 0,15613778 ! response to protozoan GO:0001562 9 5 0,000 0,04521207 0,1559037 ! lymph vessel development GO:0001945 7 5 0,000 0,04521207 0,15567031 ! endochondral ossification GO:0001958 12 5 0,000 0,04521207 0,15543762 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04521207 0,15520562 ! parathyroid gland development GO:0060017 8 5 0,000 0,04521207 0,15497431 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04521207 0,1547437 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,04521207 0,15451377 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04521207 0,15428452 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04521207 0,15405595 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04521207 0,15382805 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04521207 0,15360083 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04521207 0,15337428 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04521207 0,1531484 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04521207 0,15292318 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04521207 0,15269863 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04521207 0,15247473 ! ovulation GO:0030728 6 5 0,000 0,04521207 0,15225149 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04521207 0,1520289 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,04521207 0,15180696 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,04521207 0,15158566 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04521207 0,15136501 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04521207 0,15114501 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04521207 0,15092564 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04521207 0,15070691 ! polyol catabolic process GO:0046174 7 5 0,000 0,04521207 0,15048881 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04521207 0,15027134 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04521207 0,15005449 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04521207 0,14983828 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04521207 0,14962268 ! urea metabolic process GO:0019627 6 5 0,000 0,04521207 0,14940771 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04521207 0,14919335 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04521207 0,14897961 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04521207 0,14876647 ! neutrophil activation GO:0042119 5 5 0,000 0,04521207 0,14855395 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04521207 0,14834203 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04521207 0,14813072 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04521207 0,14792001 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04521207 0,14770989 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04521207 0,14750038 ! forebrain neuron development GO:0021884 7 5 0,000 0,04521207 0,14729145 ! melanosome organization GO:0032438 7 5 0,000 0,04521207 0,14708312 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04521207 0,14687537 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04521207 0,14666822 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04521207 0,14646164 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04521207 0,14625565 ! nucleoside transport GO:0015858 6 5 0,000 0,04521207 0,14605023 ! nucleoside salvage GO:0043174 7 5 0,000 0,04521207 0,14584539 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04521207 0,14564113 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04521207 0,14543743 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04521207 0,14523431 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04521207 0,14503175 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04521207 0,14482976 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,04521207 0,14462832 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04521207 0,14442745 ! depyrimidination GO:0045008 8 5 0,000 0,04521207 0,14422714 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04521207 0,14402738 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04521207 0,14382817 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04521207 0,14362951 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04521207 0,1434314 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04521207 0,14323384 ! monocyte differentiation GO:0030224 8 5 0,000 0,04521207 0,14303682 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04521207 0,14284034 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04521207 0,1426444 ! centrosome duplication GO:0051298 5 5 0,000 0,04521207 0,14244899 ! response to UV-C GO:0010225 6 5 0,000 0,04521207 0,14225412 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04521207 0,14205979 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04521207 0,14186598 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04521207 0,1416727 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04521207 0,14147995 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04521207 0,14128772 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04521207 0,14109602 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04521207 0,14090483 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04521207 0,14071416 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,04521207 0,14052401 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04521207 0,14033437 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04521207 0,14014524 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,04521207 0,13995661 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04521207 0,1397685 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04521207 0,13958089 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04521207 0,13939379 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04521207 0,13920718 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04521207 0,13902108 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04521207 0,13883547 ! neural tube patterning GO:0021532 6 5 0,000 0,04521207 0,13865035 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04521207 0,13846573 ! histone demethylation GO:0016577 9 5 0,000 0,04521207 0,1382816 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04521207 0,13809796 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04521207 0,13791481 GO:0032374|regulation of cholesterol transport, ! establishment of planar polarity GO:0001736 6 5 0,000 0,04521207 0,13773214 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04521207 0,13754995 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04521207 0,13736825 ! transcription termination GO:0006353 8 5 0,000 0,04521207 0,13718702 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04521207 0,13700628 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04521207 0,13682601 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04521207 0,13664621 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04521207 0,13646688 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04521207 0,13628803 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04521207 0,13610964 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04521207 0,13593172 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04521207 0,13575426 ! apical protein localization GO:0045176 6 5 0,000 0,04521207 0,13557727 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04521207 0,13540074 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04521207 0,13522466 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04521207 0,13504905 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04521207 0,13487388 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04521207 0,13469918 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04521207 0,13452492 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04521207 0,13435112 ! glial cell migration GO:0008347 10 5 0,000 0,04521207 0,13417776 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04521207 0,13400485 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04521207 0,13383239 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04521207 0,13366037 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04521207 0,13348879 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04521207 0,13331765 ! neural plate development GO:0001840 6 5 0,000 0,04521207 0,13314695 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04521207 0,13297668 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04521207 0,13280685 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04521207 0,13263746 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04521207 0,13246849 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04521207 0,13229996 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04521207 0,13213185 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04521207 0,13196417 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04521207 0,13179691 ! spindle assembly GO:0051225 5 5 0,000 0,04521207 0,13163008 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04521207 0,13146367 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04521207 0,13129768 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04521207 0,13113211 ! organ regeneration GO:0031100 7 5 0,000 0,04521207 0,13096696 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04521207 0,13080222 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04521207 0,1306379 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04521207 0,13047398 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04521207 0,13031048 GO:0055081|anion homeostasis, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,04549457 0,13096058 ! regulation of protein secretion GO:0050708 51 37 1,000 0,04549457 0,13079688 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,04636798 0,1331415 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 2,000 0,04636798 0,13297549 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,04636798 0,13280989 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,04769114 0,13642986 ! protein processing GO:0016485 114 88 2,000 0,04769114 0,13626039 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,04773835 0,13622607 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,04773835 0,13605726 ! maintenance of location in cell GO:0051651 69 38 1,000 0,04773835 0,13588888 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,04903277 0,13940095 ! regulation of T cell activation GO:0050863 128 89 2,000 0,04903277 0,13922885 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,05002178 0,14186201 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,05002178 0,1416873 ! synapse organization GO:0050808 55 39 1,000 0,05002178 0,14151302 ! response to calcium ion GO:0051592 58 40 1,000 0,05234393 0,14790054 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,05234393 0,14771907 ! B cell differentiation GO:0030183 62 40 1,000 0,05234393 0,14753804 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,05234393 0,14735745 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,05234393 0,14717731 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,05234393 0,14699761 ! sulfur metabolic process GO:0006790 118 92 2,000 0,0531675 0,14912837 ! tRNA transcription GO:0009304 11 6 0,000 0,05400768 0,15130044 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,05400768 0,15111638 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,05400768 0,15093276 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05400768 0,15074959 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05400768 0,15056687 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05400768 0,15038458 ! regulation of helicase activity GO:0051095 11 6 0,000 0,05400768 0,15020274 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05400768 0,15002133 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,05400768 0,14984037 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05400768 0,14965984 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05400768 0,14947974 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05400768 0,14930008 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05400768 0,14912085 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05400768 0,14894204 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05400768 0,14876367 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,05400768 0,14858572 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05400768 0,1484082 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05400768 0,1482311 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05400768 0,14805443 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05400768 0,14787817 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,05400768 0,14770234 ! neuron adhesion GO:0007158 9 6 0,000 0,05400768 0,14752692 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05400768 0,14735192 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05400768 0,14717733 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05400768 0,14700315 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,05400768 0,14682939 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05400768 0,14665604 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05400768 0,1464831 ! opsonization GO:0008228 8 6 0,000 0,05400768 0,14631056 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05400768 0,14613843 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05400768 0,1459667 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05400768 0,14579538 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05400768 0,14562446 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05400768 0,14545394 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05400768 0,14528382 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05400768 0,14511409 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05400768 0,14494477 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05400768 0,14477583 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05400768 0,14460729 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05400768 0,14443915 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05400768 0,14427139 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05400768 0,14410402 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05400768 0,14393704 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05400768 0,14377045 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05400768 0,14360424 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05400768 0,14343841 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05400768 0,14327297 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,05400768 0,14310791 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,05400768 0,14294323 ! thymic T cell selection GO:0045061 12 6 0,000 0,05400768 0,14277893 ! protein lipoylation GO:0009249 10 6 0,000 0,05400768 0,142615 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05400768 0,14245145 ! drug transport GO:0015893 6 6 0,000 0,05400768 0,14228828 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05400768 0,14212548 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,05400768 0,14196305 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05400768 0,14180099 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05400768 0,1416393 ! histidine metabolic process GO:0006547 6 6 0,000 0,05400768 0,14147798 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05400768 0,14131703 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,05400768 0,14115644 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,05400768 0,14099621 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,05400768 0,14083636 ! adenohypophysis development GO:0021984 10 6 0,000 0,05400768 0,14067686 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05400768 0,14051772 ! hyperosmotic response GO:0006972 8 6 0,000 0,05400768 0,14035894 ! microtubule nucleation GO:0007020 10 6 0,000 0,05400768 0,14020053 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05400768 0,14004246 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05400768 0,13988476 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05400768 0,13972741 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,05400768 0,13957041 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,05400768 0,13941377 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,05400768 0,13925747 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05400768 0,13910153 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05400768 0,13894593 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,05400768 0,13879069 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,05400768 0,13863579 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05400768 0,13848123 ! organic alcohol transport GO:0015850 9 6 0,000 0,05400768 0,13832702 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05400768 0,13817315 ! carnitine transport GO:0015879 8 6 0,000 0,05400768 0,13801963 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05400768 0,13786644 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05400768 0,1377136 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05400768 0,13756109 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05400768 0,13740892 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05400768 0,13725709 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05400768 0,13710559 ! parturition GO:0007567 12 6 0,000 0,05400768 0,13695443 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05400768 0,1368036 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05400768 0,1366531 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,05400768 0,13650293 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,05400768 0,13635309 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05400768 0,13620358 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,05400768 0,1360544 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05400768 0,13590554 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,05400768 0,13575701 ! astrocyte development GO:0014002 14 6 0,000 0,05400768 0,1356088 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05400768 0,13546092 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05400768 0,13531336 ! interaction with symbiont GO:0051702 8 6 0,000 0,05400768 0,13516612 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05400768 0,1350192 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05400768 0,1348726 ! eating behavior GO:0042755 6 6 0,000 0,05400768 0,13472632 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05400768 0,13458035 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05400768 0,1344347 ! response to copper ion GO:0046688 9 6 0,000 0,05400768 0,13428937 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05400768 0,13414435 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05400768 0,13399964 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05400768 0,13385524 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05400768 0,13371116 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05400768 0,13356738 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,05400768 0,13342392 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05400768 0,13328076 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05400768 0,1331379 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05400768 0,13299536 ! Schwann cell development GO:0014044 14 6 0,000 0,05400768 0,13285312 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05400768 0,13271118 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,05400768 0,13256955 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05400768 0,13242821 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05400768 0,13228718 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05400768 0,13214645 ! histone ubiquitination GO:0016574 7 6 0,000 0,05400768 0,13200602 ! regulation of meiosis GO:0040020 10 6 0,000 0,05400768 0,13186589 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05400768 0,13172605 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05400768 0,13158651 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05400768 0,13144726 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05400768 0,13130831 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05400768 0,13116966 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05400768 0,13103129 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05400768 0,13089322 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05400768 0,13075544 ! receptor internalization GO:0031623 9 6 0,000 0,05400768 0,13061794 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05400768 0,13048074 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05400768 0,13034382 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,05400768 0,1302072 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05400768 0,13007085 ! protein deubiquitination GO:0016579 8 6 0,000 0,05400768 0,1299348 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05400768 0,12979902 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,05400768 0,12966353 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,05400768 0,12952833 ! axonal fasciculation GO:0007413 9 6 0,000 0,05400768 0,1293934 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05400768 0,12925876 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05400768 0,12912439 ! midbrain development GO:0030901 6 6 0,000 0,05400768 0,12899031 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05400768 0,1288565 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05400768 0,12872297 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05400768 0,12858972 ! progesterone metabolic process GO:0042448 8 6 0,000 0,05400768 0,12845674 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05400768 0,12832403 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05400768 0,1281916 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05400768 0,12805945 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05400768 0,12792756 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05400768 0,12779595 ! adult feeding behavior GO:0008343 6 6 0,000 0,05400768 0,12766461 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05400768 0,12753354 ! blastocyst growth GO:0001832 15 6 0,000 0,05400768 0,12740273 ! pigment granule transport GO:0051904 12 6 0,000 0,05400768 0,1272722 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05400768 0,12714193 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05400768 0,12701193 ! catecholamine transport GO:0051937 7 6 0,000 0,05400768 0,12688219 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05400768 0,12675272 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05400768 0,12662351 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,05400768 0,12649457 ! protein prenylation GO:0018342 10 6 0,000 0,05400768 0,12636589 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05400768 0,12623746 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05400768 0,1261093 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05400768 0,1259814 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05400768 0,12585376 ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,05458202 0,1270634 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,05470391 0,12721841 ! striated muscle contraction GO:0006941 62 41 1,000 0,05470391 0,1270899 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,05470391 0,12696166 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,05470391 0,12683367 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,05470391 0,12670594 ! response to oxidative stress GO:0006979 141 94 2,000 0,05601448 0,12961097 ! mitochondrial transport GO:0006839 60 42 1,000 0,05710085 0,1319919 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,05710085 0,13185938 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,05710085 0,13172713 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,05710085 0,13159513 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,05710085 0,13146341 ! regulation of cell shape GO:0008360 78 42 1,000 0,05710085 0,13133194 ! protein maturation GO:0051604 129 96 2,000 0,05893282 0,13541008 ! positive regulation of binding GO:0051099 59 43 1,000 0,05953385 0,13665455 ! neuromuscular process GO:0050905 79 43 1,000 0,05953385 0,1365183 ! vesicle organization GO:0016050 79 43 1,000 0,05953385 0,13638233 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,06200208 0,1418953 ! ribonucleoprotein complex assembly GO:0022618 70 44 1,000 0,06200208 0,14175425 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,06200208 0,14161348 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,06200208 0,14147299 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06272276 0,14297557 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,06272276 0,14283401 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06272276 0,14269273 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06272276 0,14255173 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06272276 0,14241101 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06272276 0,14227056 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06272276 0,1421304 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,06272276 0,1419905 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06272276 0,14185089 ! reproductive behavior GO:0019098 12 7 0,000 0,06272276 0,14171154 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06272276 0,14157248 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06272276 0,14143368 ! oligopeptide transport GO:0006857 11 7 0,000 0,06272276 0,14129515 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06272276 0,1411569 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06272276 0,14101892 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,06272276 0,1408812 ! RNA methylation GO:0001510 11 7 0,000 0,06272276 0,14074376 ! pericardium development GO:0060039 8 7 0,000 0,06272276 0,14060658 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06272276 0,14046967 ! fibril organization GO:0043206 13 7 0,000 0,06272276 0,14033303 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06272276 0,14019665 ! lipoprotein transport GO:0042953 9 7 0,000 0,06272276 0,14006054 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,06272276 0,13992469 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06272276 0,1397891 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06272276 0,13965378 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06272276 0,13951872 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06272276 0,13938392 ! chemosensory behavior GO:0007635 9 7 0,000 0,06272276 0,13924938 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06272276 0,13911509 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06272276 0,13898107 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06272276 0,13884731 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06272276 0,1387138 ! reflex GO:0060004 12 7 0,000 0,06272276 0,13858055 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06272276 0,13844756 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06272276 0,13831482 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06272276 0,13818233 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06272276 0,1380501 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,06272276 0,13791812 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06272276 0,13778639 ! spinal cord patterning GO:0021511 7 7 0,000 0,06272276 0,13765492 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06272276 0,13752369 ! adrenal gland development GO:0030325 17 7 0,000 0,06272276 0,13739272 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06272276 0,13726199 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06272276 0,13713151 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06272276 0,13700128 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06272276 0,1368713 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06272276 0,13674157 ! endosome organization GO:0007032 10 7 0,000 0,06272276 0,13661208 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06272276 0,13648283 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06272276 0,13635383 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06272276 0,13622507 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06272276 0,13609656 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06272276 0,13596829 ! galactose metabolic process GO:0006012 10 7 0,000 0,06272276 0,13584026 ! vesicle fusion GO:0006906 15 7 0,000 0,06272276 0,13571247 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06272276 0,13558492 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,06272276 0,13545761 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06272276 0,13533054 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,06272276 0,1352037 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06272276 0,13507711 ! retinol metabolic process GO:0042572 9 7 0,000 0,06272276 0,13495075 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,06272276 0,13482463 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06272276 0,13469874 ! rRNA modification GO:0000154 12 7 0,000 0,06272276 0,13457309 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06272276 0,13444767 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06272276 0,13432249 ! intermediate filament organization GO:0045109 11 7 0,000 0,06272276 0,13419754 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06272276 0,13407282 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06272276 0,13394833 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,06272276 0,13382407 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06272276 0,13370005 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06272276 0,13357625 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06272276 0,13345269 ! response to tropane GO:0014073 13 7 0,000 0,06272276 0,13332935 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,06272276 0,13320624 ! melanosome localization GO:0032400 10 7 0,000 0,06272276 0,13308335 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06272276 0,13296069 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06272276 0,13283826 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06272276 0,13271606 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06272276 0,13259407 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06272276 0,13247232 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06272276 0,13235078 ! mast cell activation GO:0045576 9 7 0,000 0,06272276 0,13222947 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06272276 0,13210838 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,06272276 0,13198751 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06272276 0,13186687 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06272276 0,13174644 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,06272276 0,13162623 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06272276 0,13150625 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06272276 0,13138648 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,06272276 0,13126693 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06272276 0,13114759 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06272276 0,13102848 ! response to tumor cell GO:0002347 12 7 0,000 0,06272276 0,13090958 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06272276 0,13079089 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06272276 0,13067242 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06272276 0,13055417 ! diuresis GO:0030146 12 7 0,000 0,06272276 0,13043612 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06272276 0,13031829 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06272276 0,13020068 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06272276 0,13008328 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06272276 0,12996608 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06272276 0,1298491 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06272276 0,12973233 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06272276 0,12961577 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06272276 0,12949942 ! lymph node development GO:0048535 9 7 0,000 0,06272276 0,12938328 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06272276 0,12926734 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06272276 0,12915161 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06272276 0,12903609 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06272276 0,12892078 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06272276 0,12880567 ! ATP catabolic process GO:0006200 10 7 0,000 0,06272276 0,12869077 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06272276 0,12857607 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,06272276 0,12846158 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06272276 0,12834729 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06272276 0,1282332 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06272276 0,12811932 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06272276 0,12800564 ! muscle adaptation GO:0043500 12 7 0,000 0,06272276 0,12789216 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06272276 0,12777888 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,06272276 0,1276658 ! retina homeostasis GO:0001895 9 7 0,000 0,06272276 0,12755292 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06272276 0,12744024 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,06272276 0,12732776 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06272276 0,12721548 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06272276 0,12710339 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06272276 0,12699151 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06272276 0,12687982 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06272276 0,12676832 ! positive regulation of defense response GO:0031349 59 45 1,000 0,06450467 0,13025527 ! regulation of translational initiation GO:0006446 64 45 1,000 0,06450467 0,13014101 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,06450467 0,13002695 ! regulation of body fluid levels GO:0050878 154 100 2,000 0,06497985 0,1308701 ! protein localization in organelle GO:0033365 161 100 2,000 0,06497985 0,1307556 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,06704081 0,13478484 ! regulation of ossification GO:0030278 71 46 1,000 0,06704081 0,13466712 ! respiratory electron transport chain GO:0022904 59 47 1,000 0,06960966 0,13970525 ! viral infectious cycle GO:0019058 71 47 1,000 0,06960966 0,13958345 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,06960966 0,13946186 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,06960966 0,13934049 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,07135805 0,1427161 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,07135805 0,1425921 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,07135805 0,14246833 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,07135805 0,14234476 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,07135805 0,14222141 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,07135805 0,14209828 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,07135805 0,14197536 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,07135805 0,14185265 ! phosphate transport GO:0006817 10 8 0,000 0,07135805 0,14173015 ! N-glycan processing GO:0006491 12 8 0,000 0,07135805 0,14160786 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,07135805 0,14148579 ! UTP metabolic process GO:0046051 8 8 0,000 0,07135805 0,14136392 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,07135805 0,14124227 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,07135805 0,14112082 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,07135805 0,14099958 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,07135805 0,14087855 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,07135805 0,14075773 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,07135805 0,14063711 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,07135805 0,14051671 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,07135805 0,1403965 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,07135805 0,14027651 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,07135805 0,14015671 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,07135805 0,14003713 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,07135805 0,13991774 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,07135805 0,13979856 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,07135805 0,13967958 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,07135805 0,13956081 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,07135805 0,13944224 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,07135805 0,13932386 ! astrocyte differentiation GO:0048708 16 8 0,000 0,07135805 0,13920569 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,07135805 0,13908772 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,07135805 0,13896995 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,07135805 0,13885238 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,07135805 0,13873501 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,07135805 0,13861783 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,07135805 0,13850085 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,07135805 0,13838407 ! macrophage activation GO:0042116 12 8 0,000 0,07135805 0,13826749 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,07135805 0,1381511 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,07135805 0,13803491 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,07135805 0,13791892 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,07135805 0,13780312 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,07135805 0,13768751 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,07135805 0,1375721 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,07135805 0,13745688 ! ruffle organization GO:0031529 11 8 0,000 0,07135805 0,13734185 ! osteoblast development GO:0002076 13 8 0,000 0,07135805 0,13722702 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,07135805 0,13711237 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,07135805 0,13699792 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,07135805 0,13688366 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,07135805 0,13676959 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,07135805 0,13665571 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,07135805 0,13654202 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,07135805 0,13642852 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,07135805 0,13631521 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,07135805 0,13620208 ! brain morphogenesis GO:0048854 20 8 0,000 0,07135805 0,13608915 ! oligodendrocyte development GO:0014003 8 8 0,000 0,07135805 0,1359764 ! segment specification GO:0007379 10 8 0,000 0,07135805 0,13586383 ! cellular extravasation GO:0045123 11 8 0,000 0,07135805 0,13575146 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,07135805 0,13563927 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,07135805 0,13552726 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,07135805 0,13541544 ! snRNA metabolic process GO:0016073 10 8 0,000 0,07135805 0,1353038 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,07135805 0,13519235 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,07135805 0,13508108 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,07135805 0,13496999 ! nucleosome disassembly GO:0006337 12 8 0,000 0,07135805 0,13485909 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,07135805 0,13474837 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,07135805 0,13463783 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,07135805 0,13452747 ! icosanoid secretion GO:0032309 12 8 0,000 0,07135805 0,13441729 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,07135805 0,13430729 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,07135805 0,13419748 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,07135805 0,13408784 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,07135805 0,13397838 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,07135805 0,1338691 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,07135805 0,13375999 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,07135805 0,13365107 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,07135805 0,13354232 ! sterol catabolic process GO:0016127 9 8 0,000 0,07135805 0,13343375 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,07135805 0,13332535 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,07135805 0,13321714 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,07135805 0,13310909 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,07135805 0,13300123 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,07135805 0,13289353 ! prophase GO:0051324 11 8 0,000 0,07135805 0,13278601 ! S phase GO:0051320 8 8 0,000 0,07135805 0,13267867 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,07135805 0,1325715 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,07135805 0,1324645 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,07135805 0,13235767 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,07135805 0,13225102 ! hormone catabolic process GO:0042447 13 8 0,000 0,07135805 0,13214453 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,07135805 0,13203822 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,07135805 0,13193208 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,07135805 0,13182611 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,07135805 0,13172031 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,07135805 0,13161468 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,07135805 0,13150922 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,07135805 0,13140393 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,07135805 0,13129881 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,07135805 0,13119385 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,07135805 0,13108907 ! lamellipodium assembly GO:0030032 9 8 0,000 0,07135805 0,13098445 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,07135805 0,13087999 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,07135805 0,13077571 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,07221042 0,13223246 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,07221042 0,13212726 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,07221042 0,13202223 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,07484229 0,1367254 ! maintenance of location GO:0051235 84 49 1,000 0,07484229 0,13661688 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,07750449 0,14136426 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,07750449 0,14125224 ! lipid modification GO:0030258 73 50 1,000 0,07750449 0,1411404 ! telencephalon cell migration GO:0022029 16 9 0,000 0,07991427 0,14541362 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,07991427 0,14529867 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,07991427 0,1451839 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,07991427 0,14506931 ! CTP metabolic process GO:0046036 9 9 0,000 0,07991427 0,1449549 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,07991427 0,14484067 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,07991427 0,14472662 ! GTP metabolic process GO:0046039 9 9 0,000 0,07991427 0,14461276 ! elastic fiber assembly GO:0048251 13 9 0,000 0,07991427 0,14449907 ! social behavior GO:0035176 14 9 0,000 0,07991427 0,14438556 ! artery development GO:0060840 19 9 0,000 0,07991427 0,14427222 GO:0048844|artery morphogenesis, ! response to pain GO:0048265 16 9 0,000 0,07991427 0,14415907 ! protein complex disassembly GO:0043241 17 9 0,000 0,07991427 0,14404609 GO:0043624|cellular protein complex disassembly, ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,07991427 0,14393329 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,07991427 0,14382067 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,07991427 0,14370822 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,07991427 0,14359595 ! protein targeting to ER GO:0045047 19 9 0,000 0,07991427 0,14348385 ! endoderm development GO:0007492 12 9 0,000 0,07991427 0,14337193 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,07991427 0,14326018 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,07991427 0,14314861 ! arginine catabolic process GO:0006527 10 9 0,000 0,07991427 0,14303721 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,07991427 0,14292598 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,07991427 0,14281493 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,07991427 0,14270405 ! V(D)J recombination GO:0033151 12 9 0,000 0,07991427 0,14259334 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,07991427 0,1424828 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,07991427 0,14237243 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,07991427 0,14226224 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,07991427 0,14215221 ! mannose metabolic process GO:0006013 9 9 0,000 0,07991427 0,14204236 ! epithelial cell development GO:0002064 10 9 0,000 0,07991427 0,14193267 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,07991427 0,14182316 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,07991427 0,14171381 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,07991427 0,14160463 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,07991427 0,14149562 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,07991427 0,14138678 ! motor axon guidance GO:0008045 14 9 0,000 0,07991427 0,1412781 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,07991427 0,1411696 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,07991427 0,14106125 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,07991427 0,14095308 ! blastoderm segmentation GO:0007350 11 9 0,000 0,07991427 0,14084507 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,07991427 0,14073722 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,07991427 0,14062954 ! response to amine stimulus GO:0014075 13 9 0,000 0,07991427 0,14052203 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,07991427 0,14041468 ! erythrocyte development GO:0048821 11 9 0,000 0,07991427 0,14030749 ! renal water homeostasis GO:0003091 14 9 0,000 0,07991427 0,14020047 ! postreplication repair GO:0006301 11 9 0,000 0,07991427 0,14009361 ! mRNA cleavage GO:0006379 13 9 0,000 0,07991427 0,13998691 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,07991427 0,13988038 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,07991427 0,139774 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,07991427 0,13966779 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,07991427 0,13956174 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,07991427 0,13945585 ! acid secretion GO:0046717 14 9 0,000 0,07991427 0,13935012 ! musculoskeletal movement GO:0050881 11 9 0,000 0,07991427 0,13924456 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,07991427 0,13913915 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,07991427 0,1390339 ! purine base metabolic process GO:0006144 18 9 0,000 0,07991427 0,13892881 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,07991427 0,13882388 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,07991427 0,1387191 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,07991427 0,13861449 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,07991427 0,13851003 ! detection of calcium ion GO:0005513 13 9 0,000 0,07991427 0,13840573 ! blastocyst formation GO:0001825 12 9 0,000 0,07991427 0,13830159 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,07991427 0,1381976 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,07991427 0,13809377 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,07991427 0,1379901 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,07991427 0,13788658 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,07991427 0,13778322 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,07991427 0,13768001 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,07991427 0,13757696 ! prepulse inhibition GO:0060134 14 9 0,000 0,07991427 0,13747406 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,07991427 0,13737131 ! insulin secretion GO:0030073 17 9 0,000 0,07991427 0,13726872 ! sequestering of metal ion GO:0051238 11 9 0,000 0,07991427 0,13716628 ! establishment of cell polarity GO:0030010 12 9 0,000 0,07991427 0,13706399 ! nucleus localization GO:0051647 15 9 0,000 0,07991427 0,13696186 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,08019624 0,13734278 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,08019624 0,13724059 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,08019624 0,13713856 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,08291678 0,14168544 ! establishment of organelle localization GO:0051656 85 52 1,000 0,08291678 0,14158026 ! cell projection assembly GO:0030031 76 53 1,000 0,08566537 0,14616494 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,08839214 0,15070564 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,08839214 0,15059401 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,08839214 0,15048254 ! thyroid gland development GO:0030878 19 10 0,000 0,08839214 0,15037124 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,08839214 0,1502601 ! synapsis GO:0007129 13 10 0,000 0,08839214 0,15014912 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,08839214 0,15003831 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,08839214 0,14992766 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,08839214 0,14981718 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,08839214 0,14970686 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,08839214 0,1495967 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,08839214 0,1494867 ! androgen metabolic process GO:0008209 13 10 0,000 0,08839214 0,14937686 ! phospholipid efflux GO:0033700 16 10 0,000 0,08839214 0,14926719 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,08839214 0,14915768 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,08839214 0,14904832 ! pathogenesis GO:0009405 13 10 0,000 0,08839214 0,14893913 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,08839214 0,1488301 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,08839214 0,14872122 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,08839214 0,14861251 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,08839214 0,14850395 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,08839214 0,14839556 ! melanocyte differentiation GO:0030318 15 10 0,000 0,08839214 0,14828732 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,08839214 0,14817924 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,08839214 0,14807131 ! response to X-ray GO:0010165 16 10 0,000 0,08839214 0,14796355 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,08839214 0,14785594 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,08839214 0,14774848 ! forebrain cell migration GO:0021885 17 10 0,000 0,08839214 0,14764119 ! lipid digestion GO:0044241 15 10 0,000 0,08839214 0,14753404 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,08839214 0,14742706 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,08839214 0,14732023 ! UV protection GO:0009650 14 10 0,000 0,08839214 0,14721355 ! entry into host cell GO:0030260 20 10 0,000 0,08839214 0,14710703 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,08839214 0,14700066 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,08839214 0,14689445 ! regulation of organ growth GO:0046620 11 10 0,000 0,08839214 0,14678838 ! response to dsRNA GO:0043331 18 10 0,000 0,08839214 0,14668248 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,08839214 0,14657672 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,08839214 0,14647112 ! embryonic axis specification GO:0000578 12 10 0,000 0,08839214 0,14636567 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,08839214 0,14626037 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,08839214 0,14615522 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,08839214 0,14605022 ! cranial nerve development GO:0021545 12 10 0,000 0,08839214 0,14594538 ! fucose catabolic process GO:0019317 16 10 0,000 0,08839214 0,14584068 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,08839214 0,14573614 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,08839214 0,14563174 ! protein sumoylation GO:0016925 12 10 0,000 0,08839214 0,1455275 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,08839214 0,1454234 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,08839214 0,14531945 ! zymogen activation GO:0031638 14 10 0,000 0,08839214 0,14521565 ! salivary gland development GO:0007431 22 10 0,000 0,08839214 0,145112 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,08839214 0,1450085 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,08839214 0,14490514 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,08839214 0,14480193 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,08839214 0,14469887 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,08839214 0,14459595 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,08839214 0,14449319 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,08839214 0,14439056 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,08839214 0,14428809 ! detection of bacterium GO:0016045 10 10 0,000 0,08839214 0,14418575 ! activation of innate immune response GO:0002218 10 10 0,000 0,08839214 0,14408357 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,08839214 0,14398152 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,08839214 0,14387963 ! developmental induction GO:0031128 13 10 0,000 0,08839214 0,14377787 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,08839214 0,14367626 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,08839214 0,1435748 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,08839214 0,14347347 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,08844125 0,14345195 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,08844125 0,14335086 ! detection of external stimulus GO:0009581 66 54 1,000 0,08844125 0,14324991 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,08844125 0,1431491 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,09407201 0,15215586 ! rRNA transcription GO:0009303 17 11 0,000 0,09679237 0,15644585 ! respiratory burst GO:0045730 14 11 0,000 0,09679237 0,15633599 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,09679237 0,15622628 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,09679237 0,15611672 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,09679237 0,15600732 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,09679237 0,15589807 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,09679237 0,15578898 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,09679237 0,15568003 ! RNA polyadenylation GO:0043631 19 11 0,000 0,09679237 0,15557124 ! mating GO:0007618 14 11 0,000 0,09679237 0,1554626 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,09679237 0,15535412 ! T cell proliferation GO:0042098 20 11 0,000 0,09679237 0,15524578 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,09679237 0,15513759 ! bone resorption GO:0045453 16 11 0,000 0,09679237 0,15502956 ! regulated secretory pathway GO:0045055 14 11 0,000 0,09679237 0,15492168 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,09679237 0,15481394 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,09679237 0,15470636 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,09679237 0,15459892 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,09679237 0,15449164 ! syncytium formation GO:0006949 15 11 0,000 0,09679237 0,1543845 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,09679237 0,15427751 ! mitotic spindle organization GO:0007052 15 11 0,000 0,09679237 0,15417067 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,09679237 0,15406398 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,09679237 0,15395743 ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,09679237 0,15385103 ! adult heart development GO:0007512 11 11 0,000 0,09679237 0,15374478 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,09679237 0,15363868 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,09679237 0,15353272 ! L-glutamate transport GO:0015813 16 11 0,000 0,09679237 0,15342691 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,09679237 0,15332124 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,09679237 0,15321572 ! stem cell development GO:0048864 29 11 0,000 0,09679237 0,15311035 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,09679237 0,15300512 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,09679237 0,15290003 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,09679237 0,15279509 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,09679237 0,15269029 ! vasoconstriction GO:0042310 15 11 0,000 0,09679237 0,15258564 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,09679237 0,15248113 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,09679237 0,15237676 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,09679237 0,15227254 ! ribosome assembly GO:0042255 13 11 0,000 0,09679237 0,15216845 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,09679237 0,15206451 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,09679237 0,15196071 ! chromatin silencing GO:0006342 19 11 0,000 0,09679237 0,15185706 ! nucleosome positioning GO:0016584 13 11 0,000 0,09679237 0,15175354 ! regulation of isotype switching GO:0045191 19 11 0,000 0,09679237 0,15165017 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,09679237 0,15154693 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,09679237 0,15144384 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,09679237 0,15134089 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,09679237 0,15123808 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,09679237 0,1511354 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,09679237 0,15103287 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,09679237 0,15093047 ! male genitalia development GO:0030539 13 11 0,000 0,09679237 0,15082822 ! cholesterol efflux GO:0033344 19 11 0,000 0,09679237 0,1507261 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,09679237 0,15062412 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,09679237 0,15052228 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,09679237 0,15042057 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,09679237 0,15031901 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,09679237 0,15021758 ! defense response to fungus GO:0050832 12 11 0,000 0,09679237 0,15011628 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,09679237 0,15001513 ! lysogeny GO:0030069 18 11 0,000 0,09679237 0,14991411 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,09679237 0,14981322 ! acrosome reaction GO:0007340 13 11 0,000 0,09679237 0,14971247 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,09679237 0,14961186 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,09692547 0,14971698 GO:0048609|reproductive process in a multicellular organism, ! camera-type eye development GO:0043010 88 57 1,000 0,09692547 0,1496165 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,09980338 0,15395558 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,10270506 0,15832549 ! lactation GO:0007595 20 12 0,000 0,10511567 0,16193305 ! reproductive cellular process GO:0048610 14 12 0,000 0,10511567 0,16182466 ! tRNA modification GO:0006400 14 12 0,000 0,10511567 0,16171642 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,10511567 0,16160832 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,10511567 0,16150036 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,10511567 0,16139255 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,10511567 0,16128489 ! non-recombinational repair GO:0000726 19 12 0,000 0,10511567 0,16117736 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,10511567 0,16106998 ! peroxisomal transport GO:0043574 21 12 0,000 0,10511567 0,16096275 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,10511567 0,16085565 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,10511567 0,1607487 ! palate development GO:0060021 15 12 0,000 0,10511567 0,16064189 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,10511567 0,16053522 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,10511567 0,1604287 ! arginine metabolic process GO:0006525 13 12 0,000 0,10511567 0,16032231 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,10511567 0,16021607 ! methionine metabolic process GO:0006555 13 12 0,000 0,10511567 0,16010996 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,10511567 0,160004 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,10511567 0,15989818 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,10511567 0,15979249 ! monoamine transport GO:0015844 13 12 0,000 0,10511567 0,15968695 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,10511567 0,15958155 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,10511567 0,15947628 ! L-amino acid transport GO:0015807 20 12 0,000 0,10511567 0,15937116 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,10511567 0,15926617 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,10511567 0,15916132 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,10511567 0,15905661 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,10511567 0,15895203 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,10511567 0,1588476 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,10511567 0,1587433 ! cerebellum development GO:0021549 13 12 0,000 0,10511567 0,15863914 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,10511567 0,15853511 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,10511567 0,15843122 ! histone methylation GO:0016571 15 12 0,000 0,10511567 0,15832747 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,10511567 0,15822385 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,10511567 0,15812037 ! regulation of epidermis development GO:0045682 17 12 0,000 0,10511567 0,15801702 ! intestinal absorption GO:0050892 19 12 0,000 0,10511567 0,15791381 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,10511567 0,15781073 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,10511567 0,15770779 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,10511567 0,15760498 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,10511567 0,15750231 ! microspike assembly GO:0030035 23 12 0,000 0,10511567 0,15739977 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,10511567 0,15729736 ! response to cold GO:0009409 14 12 0,000 0,10511567 0,15719509 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,10562983 0,15786134 ! regulation of heart contraction GO:0008016 91 60 1,000 0,10562983 0,15775883 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,10857702 0,16205526 ! meiosis GO:0007126 96 61 1,000 0,10857702 0,16195016 GO:0051327|M phase of meiotic cell cycle, ! meiotic cell cycle GO:0051321 97 62 1,000 0,11154599 0,16627076 ! organelle localization GO:0051640 96 62 1,000 0,11154599 0,16616307 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,11336275 0,16876007 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,11336275 0,16865091 ! cGMP metabolic process GO:0046068 16 13 0,000 0,11336275 0,1685419 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,11336275 0,16843302 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,11336275 0,16832428 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,11336275 0,16821569 ! lipid localization GO:0010876 24 13 0,000 0,11336275 0,16810723 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,11336275 0,16799891 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,11336275 0,16789074 ! organelle fusion GO:0048284 28 13 0,000 0,11336275 0,1677827 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,11336275 0,1676748 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,11336275 0,16756704 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,11336275 0,16745942 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,11336275 0,16735193 ! response to hexose stimulus GO:0009746 19 13 0,000 0,11336275 0,16724459 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,11336275 0,16713738 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,11336275 0,16703031 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,11336275 0,16692338 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! NAD metabolic process GO:0019674 21 13 0,000 0,11336275 0,16681658 ! exocrine system development GO:0035272 27 13 0,000 0,11336275 0,16670992 ! bone mineralization GO:0030282 15 13 0,000 0,11336275 0,1666034 ! regulation of exocytosis GO:0017157 17 13 0,000 0,11336275 0,16649701 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,11336275 0,16639076 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,11336275 0,16628464 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,11336275 0,16617866 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,11336275 0,16607281 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,11336275 0,1659671 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,11336275 0,16586152 ! genitalia development GO:0048806 15 13 0,000 0,11336275 0,16575608 ! regulation of cellular pH GO:0030641 20 13 0,000 0,11336275 0,16565077 ! tissue regeneration GO:0042246 21 13 0,000 0,11336275 0,1655456 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,11336275 0,16544055 ! cofactor transport GO:0051181 19 13 0,000 0,11336275 0,16533565 ! NADP metabolic process GO:0006739 18 13 0,000 0,11336275 0,16523087 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,11336275 0,16512623 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,11336275 0,16502172 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,11336275 0,16491734 ! gas transport GO:0015669 18 13 0,000 0,11336275 0,16481309 ! heme biosynthetic process GO:0006783 20 13 0,000 0,11336275 0,16470898 ! regulation of axon extension GO:0030516 23 13 0,000 0,11336275 0,164605 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,11336275 0,16450114 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,11336275 0,16439742 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,11336275 0,16429383 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,11336275 0,16419037 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,11336275 0,16408704 ! regulation of lipase activity GO:0060191 109 63 1,000 0,11453609 0,16568114 ! adaptive immune response GO:0002250 94 64 1,000 0,11754668 0,16992921 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 1,000 0,12057714 0,17420064 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,12057714 0,17409129 ! protein oligomerization GO:0051259 100 65 1,000 0,12057714 0,17398207 ! superoxide anion generation GO:0042554 18 14 0,000 0,12153428 0,1752532 ! regulation of S phase GO:0033261 18 14 0,000 0,12153428 0,17514339 ! myotube differentiation GO:0014902 21 14 0,000 0,12153428 0,17503372 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,12153428 0,17492419 ! inositol metabolic process GO:0006020 20 14 0,000 0,12153428 0,17481479 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,12153428 0,17470553 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,12153428 0,17459641 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,12153428 0,17448742 ! gene silencing by RNA GO:0031047 20 14 0,000 0,12153428 0,17437857 ! response to cAMP GO:0051591 19 14 0,000 0,12153428 0,17426986 ! startle response GO:0001964 21 14 0,000 0,12153428 0,17416128 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,12153428 0,17405283 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,12153428 0,17394452 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,12153428 0,17383635 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,12153428 0,17372831 ! glycine metabolic process GO:0006544 22 14 0,000 0,12153428 0,1736204 ! pituitary gland development GO:0021983 23 14 0,000 0,12153428 0,17351263 ! cellular response to starvation GO:0009267 21 14 0,000 0,12153428 0,17340499 ! lysosomal transport GO:0007041 20 14 0,000 0,12153428 0,17329749 ! regulation of heart rate GO:0002027 23 14 0,000 0,12153428 0,17319012 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,12153428 0,17308288 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,12153428 0,17297577 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,12153428 0,1728688 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,12153428 0,17276196 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,12153428 0,17265525 ! axon cargo transport GO:0008088 27 14 0,000 0,12153428 0,17254867 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,12153428 0,17244223 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,12153428 0,17233591 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,12153428 0,17222973 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,12153428 0,17212368 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,12153428 0,17201775 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,12153428 0,17191196 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,12153428 0,1718063 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,12153428 0,17170077 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,12153428 0,17159537 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,12153428 0,17149009 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,12153428 0,17138495 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,12153428 0,17127993 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,12153428 0,17117505 ! cell killing GO:0001906 20 14 0,000 0,12153428 0,17107029 ! cilium assembly GO:0042384 20 14 0,000 0,12153428 0,17096566 ! peptide hormone secretion GO:0030072 23 14 0,000 0,12153428 0,17086116 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,12963097 0,18213271 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,12963097 0,18202151 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,12963097 0,18191046 ! skin development GO:0043588 25 15 0,000 0,12963097 0,18179954 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,12963097 0,18168875 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,12963097 0,1815781 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,12963097 0,18146758 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,12963097 0,1813572 ! bile acid metabolic process GO:0008206 22 15 0,000 0,12963097 0,18124695 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,12963097 0,18113684 ! adult walking behavior GO:0007628 25 15 0,000 0,12963097 0,18102686 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,12963097 0,18091701 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,12963097 0,1808073 ! myoblast differentiation GO:0045445 27 15 0,000 0,12963097 0,18069772 ! centrosome cycle GO:0007098 16 15 0,000 0,12963097 0,18058827 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,12963097 0,18047896 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,12963097 0,18036978 ! cerebral cortex development GO:0021987 29 15 0,000 0,12963097 0,18026072 ! response to osmotic stress GO:0006970 22 15 0,000 0,12963097 0,18015181 ! vesicle coating GO:0006901 25 15 0,000 0,12963097 0,18004302 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,12963097 0,17993436 ! DNA integration GO:0015074 22 15 0,000 0,12963097 0,17982584 ! peptide secretion GO:0002790 27 15 0,000 0,12963097 0,17971744 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,12963097 0,17960918 ! regulation of vasodilation GO:0042312 24 15 0,000 0,12963097 0,17950105 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,12963097 0,17939304 ! neuron recognition GO:0008038 22 15 0,000 0,12963097 0,17928517 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,12963097 0,17917743 ! biomineral formation GO:0031214 18 15 0,000 0,12963097 0,17906981 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,12963097 0,17896233 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,12963097 0,17885497 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,12963097 0,17874774 ! dopamine metabolic process GO:0042417 30 15 0,000 0,12963097 0,17864065 ! organic cation transport GO:0015695 19 15 0,000 0,12963097 0,17853368 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,12963097 0,17842683 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,12963097 0,17832012 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,12963097 0,17821353 ! learning or memory GO:0007611 123 68 1,000 0,12978163 0,17831407 ! rhythmic process GO:0048511 105 68 1,000 0,12978163 0,17820761 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,13600627 0,18664345 ! humoral immune response GO:0006959 86 70 1,000 0,13600627 0,18653215 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,13600627 0,18642099 ! hormone secretion GO:0046879 25 16 0,000 0,1376535 0,18856643 ! bone remodeling GO:0046849 24 16 0,000 0,1376535 0,18845419 ! endothelial cell migration GO:0043542 22 16 0,000 0,1376535 0,18834208 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,1376535 0,18823011 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,1376535 0,18811827 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,1376535 0,18800656 ! glial cell development GO:0021782 24 16 0,000 0,1376535 0,18789498 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,1376535 0,18778354 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,1376535 0,18767222 ! protein polyubiquitination GO:0000209 26 16 0,000 0,1376535 0,18756104 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,1376535 0,18745 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,1376535 0,18733908 ! fructose metabolic process GO:0006000 20 16 0,000 0,1376535 0,18722829 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,1376535 0,18711764 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,1376535 0,18700711 ! protein export from nucleus GO:0006611 24 16 0,000 0,1376535 0,18689672 ! negative regulation of immune response GO:0050777 28 16 0,000 0,1376535 0,18678646 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,1376535 0,18667632 ! DNA replication initiation GO:0006270 25 16 0,000 0,1376535 0,18656632 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,1376535 0,18645644 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,1376535 0,1863467 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,1376535 0,18623708 ! diencephalon development GO:0021536 25 16 0,000 0,1376535 0,1861276 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,1376535 0,18601824 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,1376535 0,18590901 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,1376535 0,18579991 ! steroid catabolic process GO:0006706 22 16 0,000 0,1376535 0,18569093 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,1376535 0,18558209 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,1376535 0,18547337 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,1376535 0,18536478 ! sperm-egg recognition GO:0035036 16 16 0,000 0,1376535 0,18525631 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,1376535 0,18514798 ! nerve development GO:0021675 18 16 0,000 0,1376535 0,18503977 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,1376535 0,18493168 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,1376535 0,18482373 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,13914335 0,18671512 ! muscle cell differentiation GO:0042692 104 71 1,000 0,13914335 0,18660625 ! negative regulation of transport GO:0051051 116 73 1,000 0,14546424 0,19496955 ! regulation of blood pressure GO:0008217 107 73 1,000 0,14546424 0,194856 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,14560253 0,19492772 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,14560253 0,19481432 ! negative regulation of defense response GO:0031348 19 17 0,000 0,14560253 0,19470105 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,14560253 0,19458792 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,14560253 0,19447492 ! glycerol metabolic process GO:0006071 20 17 0,000 0,14560253 0,19436205 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,14560253 0,19424931 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,14560253 0,1941367 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,14560253 0,19402423 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,14560253 0,19391188 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,14560253 0,19379966 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,14560253 0,19368757 ! memory GO:0007613 25 17 0,000 0,14560253 0,19357562 ! keratinization GO:0031424 17 17 0,000 0,14560253 0,19346379 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,14560253 0,19335209 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,14560253 0,19324052 ! retinoid metabolic process GO:0001523 22 17 0,000 0,14560253 0,19312907 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,14560253 0,19301776 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,14560253 0,19290658 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,14560253 0,19279552 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,14560253 0,19268459 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,14560253 0,19257379 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,14560253 0,19246311 ! membrane budding GO:0006900 29 17 0,000 0,14560253 0,19235256 ! heme metabolic process GO:0042168 27 17 0,000 0,14560253 0,19224214 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,14560253 0,19213185 ! body fluid secretion GO:0007589 27 17 0,000 0,14560253 0,19202168 ! stem cell differentiation GO:0048863 36 17 0,000 0,14560253 0,19191164 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,14560253 0,19180173 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,14560253 0,19169194 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,14560253 0,19158227 ! sensory perception of pain GO:0019233 23 17 0,000 0,14560253 0,19147274 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,14560253 0,19136332 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,14560253 0,19125403 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,14560253 0,19114487 ! synaptogenesis GO:0007416 24 17 0,000 0,14560253 0,19103583 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,14560253 0,19092692 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,14560253 0,19081813 ! cell-cell junction organization GO:0045216 25 17 0,000 0,14560253 0,19070946 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,14560253 0,19060092 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,14560253 0,1904925 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,14560253 0,1903842 ! digestion GO:0007586 97 74 1,000 0,14864695 0,19425454 ! protein import into nucleus GO:0006606 118 74 1,000 0,14864695 0,19414423 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,14864695 0,19403404 ! response to nutrient GO:0007584 104 75 1,000 0,15184379 0,19809457 ! nuclear import GO:0051170 121 75 1,000 0,15184379 0,19798227 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,15347874 0,20000062 ! positive regulation of translation GO:0045727 28 18 0,000 0,15347874 0,19988737 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,15347874 0,19977425 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,15347874 0,19966125 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,15347874 0,19954839 ! cAMP metabolic process GO:0046058 33 18 0,000 0,15347874 0,19943565 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,15347874 0,19932304 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,15347874 0,19921055 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,15347874 0,19909819 ! axis specification GO:0009798 26 18 0,000 0,15347874 0,19898596 ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,15347874 0,19887386 ! pancreas development GO:0031016 26 18 0,000 0,15347874 0,19876188 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,15347874 0,19865003 ! glutamine metabolic process GO:0006541 23 18 0,000 0,15347874 0,1985383 ! response to retinoic acid GO:0032526 25 18 0,000 0,15347874 0,1984267 ! central nervous system neuron development GO:0021954 30 18 0,000 0,15347874 0,19831522 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,15347874 0,19820387 ! fucose metabolic process GO:0006004 26 18 0,000 0,15347874 0,19809265 ! response to fungus GO:0009620 19 18 0,000 0,15347874 0,19798155 ! peptide cross-linking GO:0018149 31 18 0,000 0,15347874 0,19787057 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,15347874 0,19775972 ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,15347874 0,19764899 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,15347874 0,19753839 ! visual learning GO:0008542 35 18 0,000 0,15347874 0,19742791 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,15347874 0,19731755 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,15347874 0,19720732 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,15347874 0,19709721 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,15347874 0,19698722 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,15347874 0,19687735 ! vitamin transport GO:0051180 24 18 0,000 0,15347874 0,19676761 ! hormone transport GO:0009914 27 18 0,000 0,15347874 0,19665799 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,15347874 0,19654849 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,15347874 0,19643912 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,15347874 0,19632986 ! cell-cell recognition GO:0009988 20 18 0,000 0,15347874 0,19622073 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,15347874 0,19611172 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,15347874 0,19600283 ! regulation of glucose import GO:0046324 21 18 0,000 0,15347874 0,19589406 GO:0010827|regulation of glucose transport, ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,15347874 0,19578541 ! response to unfolded protein GO:0006986 99 76 1,000 0,15505424 0,19768556 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,15505424 0,19757604 ! protein ubiquitination GO:0016567 125 77 1,000 0,15827777 0,20157191 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,15827777 0,20146036 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,16128279 0,20517169 ! positive regulation of ossification GO:0045778 30 19 0,000 0,16128279 0,20505827 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,16128279 0,20494498 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,16128279 0,20483181 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,16128279 0,20471877 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,16128279 0,20460585 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,16128279 0,20449306 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,16128279 0,20438039 ! sensory perception of taste GO:0050909 23 19 0,000 0,16128279 0,20426785 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,16128279 0,20415543 ! smooth muscle contraction GO:0006939 36 19 0,000 0,16128279 0,20404313 ! peroxisome organization GO:0007031 29 19 0,000 0,16128279 0,20393096 ! digestive system process GO:0022600 30 19 0,000 0,16128279 0,20381891 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,16128279 0,20370698 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,16128279 0,20359518 ! response to vitamin A GO:0033189 26 19 0,000 0,16128279 0,20348349 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,16128279 0,20337194 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,16128279 0,2032605 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,16128279 0,20314918 ! plasma membrane fusion GO:0045026 23 19 0,000 0,16128279 0,20303799 ! cytolysis GO:0019835 20 19 0,000 0,16128279 0,20292692 ! vasodilation GO:0042311 33 19 0,000 0,16128279 0,20281597 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,16128279 0,20270514 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,16128279 0,20259443 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,16128279 0,20248385 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,16128279 0,20237338 ! sarcomere organization GO:0045214 23 19 0,000 0,16128279 0,20226304 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,16128279 0,20215281 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,16128279 0,20204271 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,16128279 0,20193272 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,16128279 0,20182286 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,16128279 0,20171311 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,16128279 0,20160348 ! cellular respiration GO:0045333 107 79 1,000 0,16476208 0,20584073 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,16901533 0,21103978 ! iron ion transport GO:0006826 37 20 0,000 0,16901533 0,21092527 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,16901533 0,21081088 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,16901533 0,21069662 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,16901533 0,21058249 ! response to vitamin GO:0033273 29 20 0,000 0,16901533 0,21046847 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,16901533 0,21035458 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,16901533 0,21024082 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,16901533 0,21012717 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,16901533 0,21001365 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,16901533 0,20990025 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,16901533 0,20978698 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,16901533 0,20967382 ! DNA modification GO:0006304 28 20 0,000 0,16901533 0,20956079 ! collagen fibril organization GO:0030199 45 20 0,000 0,16901533 0,20944788 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,16901533 0,20933509 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,16901533 0,20922243 ! collagen catabolic process GO:0030574 25 20 0,000 0,16901533 0,20910988 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,16901533 0,20899746 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,16901533 0,20888515 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,16901533 0,20877297 ! alditol metabolic process GO:0019400 24 20 0,000 0,16901533 0,20866091 ! actin filament-based movement GO:0030048 34 20 0,000 0,16901533 0,20854896 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,17129274 0,21124574 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 1,000 0,17457425 0,21517726 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,17667703 0,21765247 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,17667703 0,21753596 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,17667703 0,21741957 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,17667703 0,2173033 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,17667703 0,21718716 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,17667703 0,21707114 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,17667703 0,21695524 ! vesicle docking GO:0048278 27 21 0,000 0,17667703 0,21683947 ! phototransduction GO:0007602 25 21 0,000 0,17667703 0,21672382 ! visual behavior GO:0007632 39 21 0,000 0,17667703 0,2166083 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,17667703 0,2164929 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,17667703 0,21637762 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,17667703 0,21626246 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,17667703 0,21614743 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,17667703 0,21603252 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,17667703 0,21591773 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,17667703 0,21580306 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,17667703 0,21568852 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,17667703 0,21557409 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,17667703 0,21545979 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,17667703 0,21534561 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,17667703 0,21523155 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,17667703 0,21511761 ! fatty acid transport GO:0015908 30 21 0,000 0,17667703 0,21500379 ! immunoglobulin production GO:0002377 33 21 0,000 0,17667703 0,21489009 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,17667703 0,21477652 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,17667703 0,21466306 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,17667703 0,21454972 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,17667703 0,2144365 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,17667703 0,2143234 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,17667703 0,21421042 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,17667703 0,21409756 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,17667703 0,21398482 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,17667703 0,21387219 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,17667703 0,21375969 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,17667703 0,2136473 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,17667703 0,21353503 ! regulation of defense response GO:0031347 117 84 1,000 0,18116727 0,21884701 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,18426852 0,22247643 ! viral genome replication GO:0019079 29 22 0,000 0,18426852 0,2223597 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,18426852 0,2222431 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,18426852 0,22212662 ! leukocyte adhesion GO:0007159 38 22 0,000 0,18426852 0,22201026 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,18426852 0,22189403 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,18426852 0,22177791 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,18426852 0,22166192 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,18426852 0,22154605 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,18426852 0,2214303 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,18426852 0,22131467 ! lysosome organization GO:0007040 37 22 0,000 0,18426852 0,22119916 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,18426852 0,22108377 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,18426852 0,22096851 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,18426852 0,22085336 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,18426852 0,22073833 ! membrane depolarization GO:0051899 35 22 0,000 0,18426852 0,22062342 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,18426852 0,22050863 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,18426852 0,22039396 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,18426852 0,22027941 ! blastocyst development GO:0001824 37 22 0,000 0,18426852 0,22016498 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,18426852 0,22005067 ! rRNA metabolic process GO:0016072 107 85 1,000 0,18447786 0,22018635 GO:0006364|rRNA processing, ! regulation of membrane potential GO:0042391 128 85 1,000 0,18447786 0,22007214 ! embryonic pattern specification GO:0009880 31 23 0,000 0,19179044 0,22867704 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,19179044 0,22855856 ! myelination GO:0042552 35 23 0,000 0,19179044 0,22844019 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,19179044 0,22832195 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,19179044 0,22820384 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,19179044 0,22808584 ! vesicle targeting GO:0006903 32 23 0,000 0,19179044 0,22796797 ! osteoblast differentiation GO:0001649 40 23 0,000 0,19179044 0,22785022 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,19179044 0,22773258 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,19179044 0,22761508 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,19179044 0,22749769 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,19179044 0,22738042 ! cell fate determination GO:0001709 45 23 0,000 0,19179044 0,22726327 ! pentose metabolic process GO:0019321 31 23 0,000 0,19179044 0,22714625 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,19179044 0,22702934 ! spermatid development GO:0007286 33 23 0,000 0,19179044 0,22691256 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,19179044 0,2267959 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,19179044 0,22667935 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,19179044 0,22656293 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,19179044 0,22644662 ! telomere organization GO:0032200 32 23 0,000 0,19179044 0,22633043 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,19179044 0,22621437 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,19179044 0,22609842 ! regulation of amine transport GO:0051952 38 23 0,000 0,19179044 0,22598259 ! liver development GO:0001889 40 23 0,000 0,19179044 0,22586688 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,19924343 0,234524 ! initiation of viral infection GO:0019059 42 24 0,000 0,19924343 0,23440404 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,19924343 0,2342842 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,19924343 0,23416448 ! superoxide metabolic process GO:0006801 32 24 0,000 0,19924343 0,23404489 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,19924343 0,23392542 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,19924343 0,23380607 ! sperm motility GO:0030317 27 24 0,000 0,19924343 0,23368684 ! vacuole organization GO:0007033 39 24 0,000 0,19924343 0,23356773 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,19924343 0,23344875 ! base-excision repair GO:0006284 31 24 0,000 0,19924343 0,23332988 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,19924343 0,23321114 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,19924343 0,23309252 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,19924343 0,23297402 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,2011541 0,23508863 ! hormone metabolic process GO:0042445 121 90 1,000 0,2011541 0,23496924 ! response to virus GO:0009615 122 91 1,000 0,20451102 0,23876921 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,20662811 0,24111855 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,20662811 0,24099628 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,20662811 0,24087413 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,20662811 0,24075211 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,20662811 0,24063021 ! peptide transport GO:0015833 43 25 0,000 0,20662811 0,24050843 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,20662811 0,24038678 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,20662811 0,24026525 ! phospholipid transport GO:0015914 35 25 0,000 0,20662811 0,24014384 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,20662811 0,24002256 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,20662811 0,2399014 ! detection of light stimulus GO:0009583 30 25 0,000 0,20662811 0,23978036 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,20787421 0,24110473 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,21124327 0,24488887 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,21394512 0,2478961 ! translational initiation GO:0006413 43 26 0,000 0,21394512 0,24777128 ! regulation of pH GO:0006885 36 26 0,000 0,21394512 0,24764659 ! circadian rhythm GO:0007623 42 26 0,000 0,21394512 0,24752201 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,21394512 0,24739757 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,21394512 0,24727325 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,21394512 0,24714905 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,21394512 0,24702498 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,21394512 0,24690104 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,21394512 0,24677721 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,21394512 0,24665352 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,21394512 0,24652994 ! electron transport chain GO:0022900 123 94 1,000 0,21461781 0,24718125 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,22119505 0,25462893 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,22119505 0,25450156 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,22119505 0,25437431 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,22119505 0,25424718 ! membrane docking GO:0022406 39 27 0,000 0,22119505 0,25412019 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,22119505 0,25399332 ! catechol metabolic process GO:0009712 43 27 0,000 0,22119505 0,25386657 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,22119505 0,25373996 ! acute-phase response GO:0006953 42 27 0,000 0,22119505 0,25361347 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,22119505 0,2534871 ! myofibril assembly GO:0030239 36 27 0,000 0,22119505 0,25336086 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,22119505 0,25323475 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,22119505 0,25310876 ! natural killer cell activation GO:0030101 35 27 0,000 0,22119505 0,2529829 ! lipid oxidation GO:0034440 38 27 0,000 0,22119505 0,25285716 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,22119505 0,25273155 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,22119505 0,25260606 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,22119505 0,2524807 ! gene silencing GO:0016458 41 27 0,000 0,22119505 0,25235546 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,2213818 0,2524433 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,2213818 0,2523182 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,22837853 0,26016375 ! phenol metabolic process GO:0018958 44 28 0,000 0,22837853 0,26003496 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,22837853 0,25990629 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,22837853 0,25977775 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,22837853 0,25964934 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,22837853 0,25952105 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,22837853 0,25939289 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,22837853 0,25926486 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,22837853 0,25913696 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,22837853 0,25900918 GO:0002764|immune response-regulating signal transduction, ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,22837853 0,25888152 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,22837853 0,25875399 ! mesoderm formation GO:0001707 46 28 0,000 0,22837853 0,25862659 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,22837853 0,25849932 ! ensheathment of neurons GO:0007272 43 28 0,000 0,22837853 0,25837216 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,22837853 0,25824514 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,22837853 0,25811824 ! extracellular structure organization GO:0043062 156 99 1,000 0,23155949 0,26158489 ! protein import GO:0017038 156 99 1,000 0,23155949 0,26145647 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,23495908 0,26516481 ! regulation of innate immune response GO:0045088 38 29 0,000 0,23549615 0,26564058 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,23549615 0,26551037 ! protein targeting to membrane GO:0006612 53 29 0,000 0,23549615 0,26538028 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,23549615 0,26525032 ! mismatch repair GO:0006298 34 29 0,000 0,23549615 0,26512048 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,23549615 0,26499078 ! muscle cell development GO:0055001 38 29 0,000 0,23549615 0,2648612 ! formation of primary germ layer GO:0001704 48 29 0,000 0,23549615 0,26473175 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,23549615 0,26460242 ! eye morphogenesis GO:0048592 51 29 0,000 0,23549615 0,26447322 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,23549615 0,26434414 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,24254853 0,27212762 ! organic anion transport GO:0015711 51 30 0,000 0,24254853 0,27199494 ! cholesterol transport GO:0030301 46 30 0,000 0,24254853 0,27186239 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,24254853 0,27172996 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,24254853 0,27159767 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,24254853 0,27146551 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,24254853 0,27133347 ! ceramide metabolic process GO:0006672 43 30 0,000 0,24254853 0,27120156 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,24254853 0,27106978 ! adult locomotory behavior GO:0008344 47 30 0,000 0,24254853 0,27093813 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,24254853 0,27080661 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,24254853 0,27067521 ! mammary gland development GO:0030879 57 31 0,000 0,24953625 0,2783382 ! glial cell differentiation GO:0010001 55 31 0,000 0,24953625 0,27820328 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,24953625 0,27806849 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,24953625 0,27793384 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,24953625 0,27779931 ! odontogenesis GO:0042476 50 31 0,000 0,24953625 0,27766491 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,24953625 0,27753064 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,24953625 0,27739651 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,24953625 0,2772625 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,24953625 0,27712862 ! RNA modification GO:0009451 40 31 0,000 0,24953625 0,27699487 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,2564599 0,28454306 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,2564599 0,28440587 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,2564599 0,28426881 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,2564599 0,28413188 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,2564599 0,28399508 ! peripheral nervous system development GO:0007422 53 32 0,000 0,2564599 0,28385841 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,2564599 0,28372187 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,2564599 0,28358547 ! vesicle localization GO:0051648 47 32 0,000 0,2564599 0,28344919 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,26332007 0,29089153 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,26332007 0,29075188 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,26332007 0,29061236 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,26332007 0,29047298 ! actomyosin structure organization GO:0031032 43 33 0,000 0,26332007 0,29033373 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,26332007 0,29019462 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,26332007 0,29005563 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,26332007 0,28991678 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,26332007 0,28977807 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,26332007 0,28963948 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,26332007 0,28950103 ! mRNA catabolic process GO:0006402 48 34 0,000 0,27011734 0,29683224 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,27011734 0,29669048 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,27011734 0,29654886 ! feeding behavior GO:0007631 45 34 0,000 0,27011734 0,29640738 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,27011734 0,29626603 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,27011734 0,29612482 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,27011734 0,29598374 ! polyol metabolic process GO:0019751 44 34 0,000 0,27011734 0,2958428 ! aerobic respiration GO:0009060 47 34 0,000 0,27011734 0,29570199 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,27011734 0,29556131 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,27011734 0,29542077 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,27685227 0,30264269 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,27685227 0,30249892 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,27685227 0,30235528 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,27685227 0,30221178 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,27685227 0,30206841 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,27685227 0,30192519 ! protein homooligomerization GO:0051260 52 35 0,000 0,27685227 0,30178209 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,28352544 0,30890976 ! organic ether metabolic process GO:0018904 46 36 0,000 0,28352544 0,3087635 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,28352544 0,30861737 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,28352544 0,30847138 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,28352544 0,30832553 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,29013741 0,31536675 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,29013741 0,31521778 ! learning GO:0007612 67 37 0,000 0,29013741 0,31506895 ! ion transmembrane transport GO:0034220 56 37 0,000 0,29013741 0,31492026 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,29013741 0,31477171 ! amino acid activation GO:0043038 52 37 0,000 0,29013741 0,31462331 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,29013741 0,31447504 ! gliogenesis GO:0042063 71 38 0,000 0,29668873 0,32142444 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,29668873 0,32127311 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,29668873 0,32112192 ! phagocytosis GO:0006909 60 38 0,000 0,29668873 0,32097088 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,30317997 0,32783917 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,30317997 0,32768511 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,30317997 0,3275312 ! chromatin remodeling GO:0006338 68 39 0,000 0,30317997 0,32737743 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,30317997 0,3272238 ! JNK cascade GO:0007254 54 39 0,000 0,30317997 0,32707032 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,30961166 0,33385224 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,30961166 0,33369579 ! regulation of tube size GO:0035150 60 40 0,000 0,30961166 0,33353949 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,30961166 0,33338334 ! inner ear development GO:0048839 57 40 0,000 0,30961166 0,33322734 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,30961166 0,33307148 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,30961166 0,33291576 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,31598435 0,33960935 ! endosome transport GO:0016197 71 41 0,000 0,31598435 0,33945073 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,31598435 0,33929226 ! biopolymer methylation GO:0043414 62 41 0,000 0,31598435 0,33913393 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,32229859 0,34574942 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,32229859 0,34558823 ! excretion GO:0007588 63 42 0,000 0,32229859 0,34542719 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,32229859 0,3452663 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,32229859 0,34510556 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,32229859 0,34494497 ! leukocyte migration GO:0050900 60 43 0,000 0,32855489 0,35147732 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,32855489 0,35131392 ! tRNA processing GO:0008033 49 43 0,000 0,32855489 0,35115067 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,32855489 0,35098757 ! methylation GO:0032259 64 43 0,000 0,32855489 0,35082463 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,33475379 0,35727783 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,33475379 0,35711212 ! glycolysis GO:0006096 53 44 0,000 0,33475379 0,35694656 ! regulation of action potential GO:0001508 71 44 0,000 0,33475379 0,35678115 ! regulation of ion transport GO:0043269 57 44 0,000 0,33475379 0,3566159 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,33475379 0,3564508 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,33475379 0,35628585 ! RNA catabolic process GO:0006401 64 45 0,000 0,34089582 0,36265512 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,34089582 0,36248746 ! cell recognition GO:0008037 58 45 0,000 0,34089582 0,36231995 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,34698148 0,36861774 ! cell redox homeostasis GO:0045454 63 46 0,000 0,34698148 0,36844756 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,34698148 0,36827753 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,34698148 0,36810766 ! endocrine system development GO:0035270 83 47 0,000 0,35301131 0,37433195 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,35301131 0,37415945 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,35301131 0,3739871 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,35301131 0,37381492 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,35301131 0,37364289 ! chloride transport GO:0006821 67 48 0,000 0,35898579 0,37979178 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,35898579 0,37961716 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,35898579 0,3794427 ! gastrulation GO:0007369 73 48 0,000 0,35898579 0,37926841 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,35898579 0,37909427 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,35898579 0,3789203 ! regulation of endocytosis GO:0030100 63 48 0,000 0,35898579 0,37874648 ! nuclear export GO:0051168 69 48 0,000 0,35898579 0,37857282 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,36490545 0,38463911 ! sensory perception of smell GO:0007608 61 49 0,000 0,36490545 0,38446291 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,36490545 0,38428687 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,36490545 0,384111 ! RNA elongation GO:0006354 62 49 0,000 0,36490545 0,38393529 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,36490545 0,38375973 ! regulation of actin filament length GO:0030832 72 50 0,000 0,37077078 0,3897499 ! membrane fusion GO:0006944 80 50 0,000 0,37077078 0,38957185 ! proton transport GO:0015992 75 50 0,000 0,37077078 0,38939396 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,37077078 0,38921624 ! positive regulation of secretion GO:0051047 71 51 0,000 0,37658227 0,3951365 ! hydrogen transport GO:0006818 77 51 0,000 0,37658227 0,39495632 ! adult behavior GO:0030534 80 51 0,000 0,37658227 0,3947763 ! transition metal ion transport GO:0000041 74 52 0,000 0,38234041 0,40063005 ! regulation of cellular component size GO:0032535 74 52 0,000 0,38234041 0,40044761 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,38234041 0,40026534 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,38234041 0,40008323 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,3880457 0,40586863 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,3880457 0,40568414 ! single fertilization GO:0007338 59 53 0,000 0,3880457 0,40549982 ! amino acid transport GO:0006865 84 54 0,000 0,39369862 0,41122017 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,39369862 0,41103351 ! glucose catabolic process GO:0006007 66 54 0,000 0,39369862 0,41084701 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,39369862 0,41066069 ! exocytosis GO:0006887 74 55 0,000 0,39929963 0,41631421 ! mesoderm development GO:0007498 76 55 0,000 0,39929963 0,41612558 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,39929963 0,41593712 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,39929963 0,41574883 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,40484923 0,4213363 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,41034786 0,42686571 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,41034786 0,42667273 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,41579601 0,43214226 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,42119413 0,43755488 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,42654268 0,44291114 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,42654268 0,44271127 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,42654268 0,44251158 ! fertilization GO:0009566 68 60 0,000 0,42654268 0,44231207 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,43184211 0,44760561 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,43184211 0,44740399 ! extracellular matrix organization GO:0030198 103 61 0,000 0,43184211 0,44720254 ! amine catabolic process GO:0009310 90 62 0,000 0,43709286 0,45243636 ! neurotransmitter transport GO:0006836 81 62 0,000 0,43709286 0,45223283 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,43709286 0,45202949 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,43709286 0,45182633 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,44229539 0,45699883 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,44745013 0,46211734 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,44745013 0,46190992 ! hexose catabolic process GO:0019320 82 64 0,000 0,44745013 0,4617027 ! defense response to bacterium GO:0042742 73 65 0,000 0,45255753 0,46676337 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,45255753 0,46655415 ! activation of immune response GO:0002253 83 65 0,000 0,45255753 0,46634512 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,457618 0,47134859 ! antigen processing and presentation GO:0019882 96 66 0,000 0,457618 0,4711376 ! axon guidance GO:0007411 99 66 0,000 0,457618 0,4709268 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,457618 0,47071619 ! regulation of immune effector process GO:0002697 101 66 0,000 0,457618 0,47050576 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,46263198 0,47544841 ! acute inflammatory response GO:0002526 92 68 0,000 0,46759989 0,48033933 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,46759989 0,48012489 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,46759989 0,47991065 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,46759989 0,47969659 ! inorganic anion transport GO:0015698 93 68 0,000 0,46759989 0,47948273 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,47252216 0,48431416 ! amine transport GO:0015837 101 70 0,000 0,47739921 0,48909496 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,48223143 0,4938256 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,48223143 0,49360583 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,48223143 0,49338625 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,48701925 0,49806327 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,49176307 0,50269114 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,49646329 0,50727036 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,50112031 0,51180139 ! amine biosynthetic process GO:0009309 97 76 0,000 0,50573453 0,51628469 ! tRNA metabolic process GO:0006399 95 76 0,000 0,50573453 0,51605564 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,51030633 0,52048982 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,51030633 0,52025911 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,51030633 0,5200286 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,51030633 0,5197983 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,5148361 0,52418018 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,5148361 0,52394824 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,51932423 0,52828205 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,51932423 0,52804851 ! regulation of lyase activity GO:0051339 133 79 0,000 0,51932423 0,52781517 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,51932423 0,52758203 ! chromatin assembly GO:0031497 102 80 0,000 0,52377109 0,53186469 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,52377109 0,53162997 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,52377109 0,53139546 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,52817707 0,53562931 ! mRNA transport GO:0051028 121 81 0,000 0,52817707 0,53539324 ! regulation of neurological system process GO:0031644 122 81 0,000 0,52817707 0,53515739 ! vitamin metabolic process GO:0006766 103 81 0,000 0,52817707 0,53492174 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,53686787 0,54348419 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,53686787 0,54324509 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,54115341 0,54734074 ! sterol metabolic process GO:0016125 120 84 0,000 0,54115341 0,54710016 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,54539955 0,55115069 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,54960664 0,55515822 ! nucleosome organization GO:0034728 114 87 0,000 0,55377503 0,55912316 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,55377503 0,55887783 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,55377503 0,5586327 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,55790508 0,56255225 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,55790508 0,56230573 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,55790508 0,56205943 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,56199714 0,56593407 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,56199714 0,5656864 ! RNA localization GO:0006403 135 91 0,000 0,57006867 0,57355991 ! ATP metabolic process GO:0046034 137 91 0,000 0,57006867 0,57330911 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,57404883 0,57705958 ! positive regulation of immune response GO:0050778 121 92 0,000 0,57404883 0,57680748 ! DNA recombination GO:0006310 146 92 0,000 0,57404883 0,57655559 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,57799237 0,58026296 ! carboxylic acid transport GO:0046942 147 95 0,000 0,58577092 0,5878155 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,5896066 0,59140653 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,59340697 0,59495904 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,59340697 0,5946998 ! calcium ion transport GO:0006816 167 99 0,000 0,60090312 0,60194999 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,60459952 0,60538916 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,60459952 0,60512572 ! divalent metal ion transport GO:0070838 171 100 0,000 0,60459952 0,60486251 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,60459952 0,60459952