pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1158-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 4,000 2,165E-09 5,289E-06 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 3,000 1,306E-07 1,596E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 3,448E-07 2,808E-04 GO:0031272|regulation of pseudopodium assembly, ! nuclear migration GO:0007097 13 6 2,000 3,448E-07 2,106E-04 ! interaction with host GO:0051701 66 25 3,000 5,326E-07 2,602E-04 ! regulation of lipid kinase activity GO:0043550 17 8 2,000 9,619E-07 3,916E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 9,619E-07 3,357E-04 ! macrophage differentiation GO:0030225 15 9 2,000 1,44E-06 4,398E-04 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 3,000 1,918E-06 5,205E-04 ! nucleus localization GO:0051647 22 11 2,000 2,818E-06 6,884E-04 ! regulation of cell projection assembly GO:0060491 33 12 2,000 3,75E-06 8,329E-04 ! interphase of mitotic cell cycle GO:0051329 224 98 4,000 6,164E-06 1,255E-03 ! positive regulation of cell cycle GO:0045787 96 48 3,000 7,823E-06 1,47E-03 ! filopodium assembly GO:0046847 42 17 2,000 1,148E-05 2,004E-03 ! microspike assembly GO:0030035 46 18 2,000 1,375E-05 2,24E-03 ! regulation of protein complex assembly GO:0043254 132 63 3,000 2,324E-05 3,549E-03 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 2,474E-05 3,556E-03 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 2,795E-05 3,794E-03 ! positive regulation of DNA replication GO:0045740 44 23 2,000 2,956E-05 3,801E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 3,333E-05 4,071E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 3,372E-05 3,923E-03 ! negative regulation of kinase activity GO:0033673 145 70 3,000 3,528E-05 3,918E-03 ! positive regulation of fibroblast proliferation GO:0048146 48 25 2,000 3,825E-05 4,063E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 3,825E-05 3,894E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 2,000 4,316E-05 4,217E-03 ! negative regulation of transferase activity GO:0051348 155 74 3,000 4,392E-05 4,127E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 4,846E-05 4,385E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 4,846E-05 4,228E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 5,417E-05 4,564E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 5,417E-05 4,411E-03 ! peptidyl-tyrosine modification GO:0018212 57 28 2,000 5,417E-05 4,269E-03 ! protein oligomerization GO:0051259 149 79 3,000 5,678E-05 4,335E-03 ! regulation of peptidase activity GO:0052547 150 82 3,000 6,57E-05 4,864E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 6,688E-05 4,806E-03 ! protein maturation by protein folding GO:0022417 14 5 1,000 6,738E-05 4,703E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 6,738E-05 4,572E-03 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 1,000 6,738E-05 4,449E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 6,738E-05 4,332E-03 ! positive regulation of vasoconstriction GO:0045907 10 5 1,000 6,738E-05 4,221E-03 ! sequestering of calcium ion GO:0051208 7 5 1,000 6,738E-05 4,115E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 6,738E-05 4,015E-03 ! regulation of cell cycle process GO:0010564 161 90 3,000 9,447E-05 5,495E-03 ! protein refolding GO:0042026 15 6 1,000 1,009E-04 5,732E-03 ! interaction with symbiont GO:0051702 14 6 1,000 1,009E-04 5,602E-03 ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 1,009E-04 5,478E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 1,073E-04 5,699E-03 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 1,369E-04 7,115E-03 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 1,369E-04 6,967E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,41E-04 7,031E-03 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 1,000 1,41E-04 6,89E-03 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 1,000 1,41E-04 6,755E-03 GO:0031958|corticosteroid receptor signaling pathway, ! vesicle fusion GO:0006906 20 7 1,000 1,41E-04 6,625E-03 ! male sex determination GO:0030238 15 7 1,000 1,41E-04 6,5E-03 ! regulation of meiosis GO:0040020 12 7 1,000 1,41E-04 6,38E-03 GO:0051445|regulation of meiotic cell cycle, ! positive regulation of microtubule polymerization GO:0031116 15 7 1,000 1,41E-04 6,264E-03 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 1,72E-04 7,503E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,877E-04 8,045E-03 ! chaperone-mediated protein complex assembly GO:0051131 13 8 1,000 1,877E-04 7,906E-03 ! outer mitochondrial membrane organization GO:0007008 16 8 1,000 1,877E-04 7,772E-03 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 1,877E-04 7,642E-03 ! gas homeostasis GO:0033483 14 8 1,000 1,877E-04 7,517E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 1,877E-04 7,396E-03 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 1,000 1,877E-04 7,279E-03 ! regulation of microtubule polymerization GO:0031113 17 8 1,000 1,877E-04 7,165E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 2,000 2,272E-04 8,54E-03 ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 2,272E-04 8,41E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 2,409E-04 8,784E-03 ! regulation of epithelial cell differentiation GO:0030856 18 9 1,000 2,409E-04 8,655E-03 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 1,000 2,409E-04 8,53E-03 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 20 9 1,000 2,409E-04 8,408E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 2,409E-04 8,289E-03 ! S phase GO:0051320 10 9 1,000 2,409E-04 8,174E-03 GO:0000084|S phase of mitotic cell cycle, ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 2,426E-04 8,119E-03 ! response to insulin stimulus GO:0032868 98 47 2,000 2,587E-04 8,539E-03 ! protein homooligomerization GO:0051260 84 49 2,000 2,928E-04 9,537E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 3,006E-04 9,664E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 3,006E-04 9,538E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 3,006E-04 9,416E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 3,006E-04 9,297E-03 ! positive regulation of phagocytosis GO:0050766 14 10 1,000 3,006E-04 9,18E-03 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 3,006E-04 9,067E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 3,006E-04 8,957E-03 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of cell projection organization GO:0031344 135 51 2,000 3,297E-04 9,704E-03 ! cortical actin cytoskeleton organization GO:0030866 29 11 1,000 3,668E-04 0,01066805 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 3,668E-04 0,01054254 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 3,668E-04 0,01041996 ! sequestering of metal ion GO:0051238 15 11 1,000 3,668E-04 0,01030019 ! regulation of embryonic development GO:0045995 35 11 1,000 3,668E-04 0,01018314 ! response to UV GO:0009411 120 55 2,000 4,122E-04 0,01131485 ! regulation of DNA replication GO:0006275 105 56 2,000 4,347E-04 0,01180014 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 4,394E-04 0,01179678 ! cortical cytoskeleton organization GO:0030865 30 12 1,000 4,394E-04 0,01166856 ! virus-host interaction GO:0019048 30 12 1,000 4,394E-04 0,01154309 ! regulation of B cell proliferation GO:0030888 22 12 1,000 4,394E-04 0,01142029 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 4,394E-04 0,01130008 ! entry into host cell GO:0030260 34 12 1,000 4,394E-04 0,01118237 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! regulation of phagocytosis GO:0050764 17 12 1,000 4,394E-04 0,01106708 ! histone acetylation GO:0016573 27 12 1,000 4,394E-04 0,01095415 ! peptidyl-lysine modification GO:0018205 21 12 1,000 4,394E-04 0,01084351 ! localization within membrane GO:0051668 26 12 1,000 4,394E-04 0,01073507 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 4,58E-04 0,01107818 ! positive regulation of cell migration GO:0030335 137 58 2,000 4,821E-04 0,01154607 ! aging GO:0007568 112 58 2,000 4,821E-04 0,01143397 ! positive regulation of organelle organization GO:0010638 108 58 2,000 4,821E-04 0,01132403 ! establishment of organelle localization GO:0051656 122 59 2,000 5,069E-04 0,01179474 ! organelle fusion GO:0048284 36 13 1,000 5,184E-04 0,01194839 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 5,184E-04 0,01183672 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 5,184E-04 0,01172712 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 1,000 5,184E-04 0,01161953 ! gland morphogenesis GO:0022612 31 13 1,000 5,184E-04 0,0115139 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 5,184E-04 0,01141017 ! viral reproductive process GO:0022415 132 62 2,000 5,864E-04 0,01279133 ! lipid localization GO:0010876 32 14 1,000 6,038E-04 0,01305398 GO:0019915|lipid storage, ! positive regulation of protein polymerization GO:0032273 27 14 1,000 6,038E-04 0,01293948 ! regulation of mitosis GO:0007088 112 63 2,000 6,146E-04 0,01305584 GO:0051783|regulation of nuclear division, ! response to peptide hormone stimulus GO:0043434 129 64 2,000 6,436E-04 0,01355422 ! positive regulation of cell motion GO:0051272 157 65 2,000 6,735E-04 0,01406203 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 6,955E-04 0,01439949 ! regulation of vasodilation GO:0042312 27 15 1,000 6,955E-04 0,01427849 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 6,955E-04 0,0141595 ! cell killing GO:0001906 32 15 1,000 6,955E-04 0,01404248 ! activation of MAPK activity GO:0000187 124 67 2,000 7,358E-04 0,01473438 ! myeloid cell differentiation GO:0030099 126 67 2,000 7,358E-04 0,01461459 ! viral reproduction GO:0016032 142 68 2,000 7,683E-04 0,01513721 ! cell projection assembly GO:0030031 138 68 2,000 7,683E-04 0,01501611 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 7,935E-04 0,01538546 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 1,000 7,935E-04 0,01526432 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 7,935E-04 0,01514507 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 1,000 8,978E-04 0,01700236 ! complement activation, alternative pathway GO:0006957 19 17 1,000 8,978E-04 0,01687157 ! regulation of MAPKKK cascade GO:0043408 157 72 2,000 9,075E-04 0,01692304 ! regulation of caspase activity GO:0043281 136 74 2,000 9,826E-04 0,01818591 ! organelle localization GO:0051640 155 74 2,000 9,826E-04 0,01804917 ! positive regulation of protein complex assembly GO:0031334 34 18 1,000 1,008E-03 0,01838259 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 1,008E-03 0,01824643 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 1,103E-03 0,01980572 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 1,125E-03 0,02006116 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 1,000 1,125E-03 0,01991579 ! peptide cross-linking GO:0018149 39 19 1,000 1,125E-03 0,01977251 ! protein export from nucleus GO:0006611 40 19 1,000 1,125E-03 0,01963128 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 1,248E-03 0,02162099 ! protein amino acid acetylation GO:0006473 41 20 1,000 1,248E-03 0,02146873 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 1,248E-03 0,0213186 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 1,248E-03 0,02117055 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of fatty acid metabolic process GO:0019217 45 20 1,000 1,248E-03 0,02102455 ! negative regulation of translation GO:0017148 32 20 1,000 1,248E-03 0,02088054 ! response to hypoxia GO:0001666 178 81 2,000 1,276E-03 0,02121158 ! response to oxygen levels GO:0070482 183 83 2,000 1,369E-03 0,02260301 ! lipid phosphorylation GO:0046834 43 21 1,000 1,377E-03 0,02257536 ! regulation of vasoconstriction GO:0019229 40 21 1,000 1,377E-03 0,02242486 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 1,466E-03 0,02372539 ! inactivation of MAPK activity GO:0000188 45 22 1,000 1,512E-03 0,02430138 ! cell aging GO:0007569 48 22 1,000 1,512E-03 0,02414254 ! cytolysis GO:0019835 27 22 1,000 1,512E-03 0,02398578 ! G1 phase GO:0051318 44 22 1,000 1,512E-03 0,02383103 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 1,512E-03 0,02367827 ! positive regulation of B cell activation GO:0050871 42 22 1,000 1,512E-03 0,02352745 ! protein stabilization GO:0050821 41 22 1,000 1,512E-03 0,02337854 ! regulation of cell-matrix adhesion GO:0001952 81 23 1,000 1,653E-03 0,02540077 GO:0010810|regulation of cell-substrate adhesion, ! positive regulation of cell adhesion GO:0045785 61 24 1,000 1,8E-03 0,02748993 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 1,8E-03 0,02731918 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 1,8E-03 0,02715055 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 1,8E-03 0,02698398 ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 1,8E-03 0,02681944 ! sex determination GO:0007530 48 24 1,000 1,8E-03 0,0266569 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 1,8E-03 0,02649632 ! membrane depolarization GO:0051899 45 24 1,000 1,8E-03 0,02633766 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 1,8E-03 0,02618089 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 1,954E-03 0,02824102 ! vasculogenesis GO:0001570 49 25 1,000 1,954E-03 0,02807489 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 1,954E-03 0,02791071 ! protein tetramerization GO:0051262 57 25 1,000 1,954E-03 0,02774844 ! initiation of viral infection GO:0019059 60 26 1,000 2,113E-03 0,02983626 ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 2,113E-03 0,02966479 ! regulation of smooth muscle contraction GO:0006940 48 26 1,000 2,113E-03 0,02949528 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 2,113E-03 0,02932769 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 1,000 2,113E-03 0,029162 ! regulation of blood coagulation GO:0030193 46 26 1,000 2,113E-03 0,02899816 ! positive regulation of nuclear division GO:0051785 41 26 1,000 2,113E-03 0,02883616 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 2,113E-03 0,02867596 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 2,14E-03 0,02888603 ! leukocyte differentiation GO:0002521 232 98 2,000 2,204E-03 0,02957878 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 2,278E-03 0,03041058 ! mitochondrial membrane organization GO:0007006 60 27 1,000 2,278E-03 0,0302453 ! skeletal muscle tissue development GO:0007519 223 100 2,000 2,334E-03 0,03082038 GO:0060538|skeletal muscle organ development, ! protein amino acid acylation GO:0043543 59 28 1,000 2,449E-03 0,0321669 ! vesicle docking GO:0048278 55 28 1,000 2,449E-03 0,03199488 ! respiratory gaseous exchange GO:0007585 61 29 1,000 2,626E-03 0,03412403 ! somitogenesis GO:0001756 52 29 1,000 2,626E-03 0,03394348 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 2,626E-03 0,03376483 ! complement activation, classical pathway GO:0006958 51 30 1,000 2,809E-03 0,03592609 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 1,000 2,809E-03 0,03573898 ! negative regulation of protein kinase cascade GO:0010741 72 30 1,000 2,809E-03 0,0355538 ! regulation of B cell activation GO:0050864 55 30 1,000 2,809E-03 0,03537053 ! regulation of coagulation GO:0050818 52 30 1,000 2,809E-03 0,03518915 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 2,997E-03 0,03736053 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 2,997E-03 0,03717089 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 1,000 3,192E-03 0,03938174 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 3,192E-03 0,03918384 ! positive regulation of catabolic process GO:0009896 72 32 1,000 3,192E-03 0,03898792 ! cholesterol homeostasis GO:0042632 60 33 1,000 3,392E-03 0,04122671 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 46 33 1,000 3,392E-03 0,04102262 ! cholesterol transport GO:0030301 62 34 1,000 3,598E-03 0,04329823 ! negative regulation of MAP kinase activity GO:0043407 78 34 1,000 3,598E-03 0,04308599 ! positive regulation of endocytosis GO:0045807 56 35 1,000 3,809E-03 0,04539721 ! membrane docking GO:0022406 69 35 1,000 3,809E-03 0,04517683 ! sterol transport GO:0015918 63 35 1,000 3,809E-03 0,04495859 ! calcium-mediated signaling GO:0019722 67 35 1,000 3,809E-03 0,04474244 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 1,000 4,027E-03 0,04706772 ! tissue remodeling GO:0048771 78 37 1,000 4,25E-03 0,04943639 ! regulation of microtubule-based process GO:0032886 86 37 1,000 4,25E-03 0,0492021 ! neutral lipid metabolic process GO:0006638 54 38 1,000 4,478E-03 0,05160294 GO:0006639|acylglycerol metabolic process, ! regulation of protein stability GO:0031647 77 38 1,000 4,478E-03 0,05136067 ! carbohydrate homeostasis GO:0033500 59 39 1,000 4,712E-03 0,05379262 GO:0042593|glucose homeostasis, ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 4,712E-03 0,05354242 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 1,000 4,952E-03 0,05600444 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 1,000 4,952E-03 0,05574636 ! lipid homeostasis GO:0055088 75 40 1,000 4,952E-03 0,05549064 ! mismatch repair GO:0006298 58 40 1,000 4,952E-03 0,05523726 ! glycerol ether metabolic process GO:0006662 57 40 1,000 4,952E-03 0,05498618 ! gliogenesis GO:0042063 91 41 1,000 5,197E-03 0,05744692 ! organic ether metabolic process GO:0018904 59 42 1,000 5,447E-03 0,05994584 ! regulation of intracellular protein transport GO:0033157 86 42 1,000 5,447E-03 0,05967703 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 5,703E-03 0,06220316 GO:0090047|positive regulation of transcription regulator activity, ! segmentation GO:0035282 78 43 1,000 5,703E-03 0,0619267 ! regulation of myeloid cell differentiation GO:0045637 105 43 1,000 5,703E-03 0,06165269 ! receptor-mediated endocytosis GO:0006898 98 45 1,000 6,232E-03 0,0670672 ! keratinocyte differentiation GO:0030216 81 45 1,000 6,232E-03 0,06677305 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 1,000 6,504E-03 0,06938571 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 6,504E-03 0,06908403 ! positive regulation of protein transport GO:0051222 80 46 1,000 6,504E-03 0,06878496 ! regulation of JNK cascade GO:0046328 104 47 1,000 6,782E-03 0,07141136 ! mitochondrial transport GO:0006839 94 48 1,000 7,064E-03 0,07407085 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 7,064E-03 0,07375431 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 7,064E-03 0,07344046 ! positive regulation of DNA binding GO:0043388 83 48 1,000 7,064E-03 0,07312927 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 7,353E-03 0,07579104 ! activation of caspase activity GO:0006919 95 50 1,000 7,646E-03 0,07848431 ! regulation of ossification GO:0030278 123 50 1,000 7,646E-03 0,07815593 ! immunoglobulin mediated immune response GO:0016064 89 50 1,000 7,646E-03 0,07783028 GO:0019724|B cell mediated immunity, ! epidermal cell differentiation GO:0009913 87 50 1,000 7,646E-03 0,07750733 ! viral infectious cycle GO:0019058 104 51 1,000 7,945E-03 0,0802017 ! positive regulation of binding GO:0051099 88 52 1,000 8,248E-03 0,08292608 ! excretion GO:0007588 87 52 1,000 8,248E-03 0,08258622 ! histone modification GO:0016570 104 52 1,000 8,248E-03 0,08224914 ! positive regulation of growth GO:0045927 96 53 1,000 8,557E-03 0,08498325 ! vesicle organization GO:0016050 127 53 1,000 8,557E-03 0,08463919 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 8,557E-03 0,0842979 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! activation of phospholipase C activity GO:0007202 110 54 1,000 8,872E-03 0,08704122 GO:0010863|positive regulation of phospholipase C activity, ! regulation of muscle contraction GO:0006937 94 54 1,000 8,872E-03 0,08669305 ! membrane fusion GO:0006944 122 54 1,000 8,872E-03 0,08634766 ! covalent chromatin modification GO:0016569 115 54 1,000 8,872E-03 0,08600501 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 9,191E-03 0,08874751 ! regulation of protein polymerization GO:0032271 117 55 1,000 9,191E-03 0,08839811 ! regulation of bone remodeling GO:0046850 143 57 1,000 9,844E-03 0,09431366 ! positive regulation of caspase activity GO:0043280 108 57 1,000 9,844E-03 0,09394525 GO:0010952|positive regulation of peptidase activity, ! regulation of phospholipase activity GO:0010517 113 57 1,000 9,844E-03 0,0935797 ! heart morphogenesis GO:0003007 105 57 1,000 9,844E-03 0,09321699 ! regulation of intracellular transport GO:0032386 108 57 1,000 9,844E-03 0,09285708 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,01017882 0,09564174 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,01017882 0,09527529 ! maintenance of location GO:0051235 124 58 1,000 0,01017882 0,09491165 ! nuclear export GO:0051168 110 59 1,000 0,01051818 0,09770311 ! lipid modification GO:0030258 112 60 1,000 0,01086251 0,10051938 ! regulation of endocytosis GO:0030100 104 60 1,000 0,01086251 0,10014006 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,01121178 0,10297135 ! DNA damage response, signal transduction GO:0042770 136 62 1,000 0,01156596 0,10582635 ! regulation of homeostatic process GO:0032844 148 62 1,000 0,01156596 0,10543148 ! lymphocyte mediated immunity GO:0002449 122 65 1,000 0,01265768 0,11495434 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01301482 0,11776006 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01301482 0,11732552 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01301482 0,11689418 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01301482 0,116466 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01301482 0,11604094 ! neuron fate determination GO:0048664 7 5 0,000 0,01301482 0,11561897 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01301482 0,11520006 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01301482 0,11478418 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01301482 0,11437128 ! polyol transport GO:0015791 12 5 0,000 0,01301482 0,11396135 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01301482 0,11355435 ! response to superoxide GO:0000303 10 5 0,000 0,01301482 0,11315024 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01301482 0,112749 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01301482 0,11235059 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01301482 0,11195499 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01301482 0,11156216 ! female meiosis GO:0007143 10 5 0,000 0,01301482 0,11117209 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01301482 0,11078473 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01301482 0,11040006 ! hypothalamus development GO:0021854 9 5 0,000 0,01301482 0,11001805 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01301482 0,10963868 ! cobalt ion transport GO:0006824 11 5 0,000 0,01301482 0,10926191 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01301482 0,10888773 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01301482 0,1085161 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01301482 0,108147 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01301482 0,1077804 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01301482 0,10741627 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01301482 0,1070546 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01301482 0,10669536 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01301482 0,10633852 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01301482 0,10598406 ! transposition GO:0032196 9 5 0,000 0,01301482 0,10563195 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01301482 0,10528217 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01301482 0,10493471 ! negative chemotaxis GO:0050919 16 5 0,000 0,01301482 0,10458953 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01301482 0,10424661 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01301482 0,10390594 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01301482 0,10356748 ! behavioral response to pain GO:0048266 10 5 0,000 0,01301482 0,10323122 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01301482 0,10289714 ! Notch receptor processing GO:0007220 11 5 0,000 0,01301482 0,10256522 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01301482 0,10223542 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01301482 0,10190775 ! micturition GO:0060073 9 5 0,000 0,01301482 0,10158216 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01301482 0,10125865 ! copulation GO:0007620 9 5 0,000 0,01301482 0,1009372 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01301482 0,10061777 ! bioluminescence GO:0008218 9 5 0,000 0,01301482 0,10030037 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01301482 0,09998496 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01301482 0,09967153 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01301482 0,09936005 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01301482 0,09905052 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01301482 0,09874291 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01301482 0,0984372 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01301482 0,09813339 ! grooming behavior GO:0007625 6 5 0,000 0,01301482 0,09783144 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01301482 0,09753134 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01301482 0,09723308 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01301482 0,09693664 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01301482 0,096642 ! response to protozoan GO:0001562 13 5 0,000 0,01301482 0,09634914 ! lymph vessel development GO:0001945 10 5 0,000 0,01301482 0,09605806 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01301482 0,09576873 ! endochondral ossification GO:0001958 17 5 0,000 0,01301482 0,09548113 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01301482 0,09519526 ! single strand break repair GO:0000012 8 5 0,000 0,01301482 0,0949111 ! parathyroid gland development GO:0060017 14 5 0,000 0,01301482 0,09462862 ! anagen GO:0042640 7 5 0,000 0,01301482 0,09434782 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01301482 0,09406869 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01301482 0,0937912 ! cytokine secretion GO:0050663 15 5 0,000 0,01301482 0,09351534 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01301482 0,09324111 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01301482 0,09296847 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01301482 0,09269743 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01301482 0,09242796 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01301482 0,09216005 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01301482 0,09189369 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01301482 0,09162887 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01301482 0,09136557 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01301482 0,09110377 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01301482 0,09084348 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01301482 0,09058466 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01301482 0,09032732 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01301482 0,09007144 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01301482 0,089817 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01301482 0,08956399 ! microvillus organization GO:0032528 8 5 0,000 0,01301482 0,08931241 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01301482 0,08906223 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01301482 0,08881345 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01301482 0,08856606 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01301482 0,08832005 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01301482 0,08807539 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01301482 0,08783209 ! polyol catabolic process GO:0046174 9 5 0,000 0,01301482 0,08759013 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01301482 0,0873495 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01301482 0,08711018 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01301482 0,08687218 ! muscle cell migration GO:0014812 8 5 0,000 0,01301482 0,08663547 ! mitochondrial fission GO:0000266 8 5 0,000 0,01301482 0,08640005 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01301482 0,0861659 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01301482 0,08593302 ! mRNA transcription GO:0009299 10 5 0,000 0,01301482 0,08570139 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01301482 0,08547101 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01301482 0,08524187 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01301482 0,08501395 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01301482 0,08478724 ! monocyte activation GO:0042117 10 5 0,000 0,01301482 0,08456175 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01301482 0,08433745 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01301482 0,08411433 ! response to food GO:0032094 6 5 0,000 0,01301482 0,08389239 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01301482 0,08367162 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01301482 0,08345201 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01301482 0,08323355 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01301482 0,08301623 ! forebrain neuron development GO:0021884 13 5 0,000 0,01301482 0,08280004 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01301482 0,08258498 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01301482 0,08237103 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01301482 0,08215818 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01301482 0,08194644 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01301482 0,08173578 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01301482 0,0815262 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01301482 0,08131769 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01301482 0,08111025 ! lipid glycosylation GO:0030259 7 5 0,000 0,01301482 0,08090386 ! nucleobase transport GO:0015851 6 5 0,000 0,01301482 0,08069852 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01301482 0,08049422 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01301482 0,08029095 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01301482 0,08008871 ! basic amino acid transport GO:0015802 12 5 0,000 0,01301482 0,07988748 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01301482 0,07968726 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01301482 0,07948804 ! actin nucleation GO:0045010 11 5 0,000 0,01301482 0,07928982 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01301482 0,07909258 ! depurination GO:0045007 5 5 0,000 0,01301482 0,07889632 ! depyrimidination GO:0045008 10 5 0,000 0,01301482 0,07870103 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01301482 0,07850671 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01301482 0,07831334 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01301482 0,07812093 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01301482 0,07792945 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01301482 0,07773892 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01301482 0,07754931 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01301482 0,07736062 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01301482 0,07717286 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01301482 0,076986 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01301482 0,07680004 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01301482 0,07661498 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01301482 0,07643081 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01301482 0,07624752 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01301482 0,07606511 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01301482 0,07588357 ! response to arsenic GO:0046685 11 5 0,000 0,01301482 0,0757029 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01301482 0,07552308 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01301482 0,07534412 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01301482 0,075166 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01301482 0,07498872 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01301482 0,07481227 ! response to mercury ion GO:0046689 8 5 0,000 0,01301482 0,07463666 ! response to cadmium ion GO:0046686 7 5 0,000 0,01301482 0,07446187 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01301482 0,07428789 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01301482 0,07411472 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01301482 0,07394236 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01301482 0,0737708 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01301482 0,07360004 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01301482 0,07343006 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01301482 0,07326087 ! decidualization GO:0046697 11 5 0,000 0,01301482 0,07309245 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01301482 0,07292481 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01301482 0,07275793 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01301482 0,07259182 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01301482 0,07242646 ! embryonic cleavage GO:0040016 6 5 0,000 0,01301482 0,07226186 ! peroxisome fission GO:0016559 5 5 0,000 0,01301482 0,072098 ! histone demethylation GO:0016577 13 5 0,000 0,01301482 0,07193488 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01301482 0,0717725 ! mitotic recombination GO:0006312 9 5 0,000 0,01301482 0,07161085 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01301482 0,07144993 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01301482 0,07128972 ! metaphase plate congression GO:0051310 7 5 0,000 0,01301482 0,07113024 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01301482 0,07097147 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01301482 0,0708134 ! enteric nervous system development GO:0048484 8 5 0,000 0,01301482 0,07065604 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01301482 0,07049937 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01301482 0,0703434 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01301482 0,07018812 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01301482 0,07003352 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01301482 0,0698796 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01301482 0,06972635 ! B cell homeostasis GO:0001782 13 5 0,000 0,01301482 0,06957378 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01301482 0,06942187 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01301482 0,06927062 ! metaphase GO:0051323 11 5 0,000 0,01301482 0,06912004 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01301482 0,0689701 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01301482 0,06882082 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01301482 0,06867217 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01301482 0,06852417 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01301482 0,06837681 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01301482 0,06823008 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01301482 0,06808398 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01301482 0,0679385 ! response to redox state GO:0051775 6 5 0,000 0,01301482 0,06779364 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01301482 0,0676494 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01301482 0,06750577 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01301482 0,06736275 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01301482 0,06722033 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01301482 0,06707852 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01301482 0,0669373 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01301482 0,06679667 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01301482 0,06665664 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01301482 0,06651719 ! striatum development GO:0021756 14 5 0,000 0,01301482 0,06637832 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01301482 0,06624004 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01301482 0,06610232 ! glial cell migration GO:0008347 10 5 0,000 0,01301482 0,06596518 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01301482 0,06582861 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01301482 0,0656926 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01301482 0,06555715 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01301482 0,06542226 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01301482 0,06528792 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01301482 0,06515413 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01301482 0,06502089 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01301482 0,0648882 ! neuroprotection GO:0043526 8 5 0,000 0,01301482 0,06475604 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01301482 0,06462442 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01301482 0,06449334 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01301482 0,06436279 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01301482 0,06423276 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01301482 0,06410326 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01301482 0,06397428 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01301482 0,06384582 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01301482 0,06371787 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01301482 0,06359043 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01301482 0,06346351 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01301482 0,06333709 ! spindle assembly GO:0051225 6 5 0,000 0,01301482 0,06321117 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01301482 0,06308575 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01301482 0,06296083 ! protein palmitoylation GO:0018345 12 5 0,000 0,01301482 0,0628364 ! drug metabolic process GO:0017144 7 5 0,000 0,01301482 0,06271246 ! stem cell division GO:0017145 11 5 0,000 0,01301482 0,06258901 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01301482 0,06246604 ! organ regeneration GO:0031100 7 5 0,000 0,01301482 0,06234356 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01301482 0,06222156 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01301482 0,06210003 ! steroid hormone receptor signaling pathway GO:0030518 146 66 1,000 0,01303123 0,0620571 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,01340955 0,06373449 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,01379262 0,06542789 ! regulation of lipase activity GO:0060191 137 68 1,000 0,01379262 0,06530109 ! adaptive immune response GO:0002250 126 68 1,000 0,01379262 0,06517478 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of cell size GO:0045792 144 69 1,000 0,0141804 0,06687785 ! lung development GO:0030324 165 69 1,000 0,0141804 0,06674899 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,0141804 0,06662063 ! activation of immune response GO:0002253 120 70 1,000 0,01457289 0,06833313 ! protein maturation by peptide bond cleavage GO:0051605 118 70 1,000 0,01457289 0,06820222 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 1,000 0,01497003 0,06992694 ! respiratory tube development GO:0030323 171 72 1,000 0,01537182 0,07166672 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01559761 0,07258088 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01559761 0,07244289 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01559761 0,07230543 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01559761 0,07216849 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01559761 0,07203206 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01559761 0,07189616 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01559761 0,07176076 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01559761 0,07162587 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01559761 0,07149149 ! response to oxygen radical GO:0000305 11 6 0,000 0,01559761 0,07135761 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01559761 0,07122423 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01559761 0,07109135 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01559761 0,07095896 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01559761 0,07082707 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01559761 0,07069566 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01559761 0,07056475 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01559761 0,07043431 ! forebrain regionalization GO:0021871 9 6 0,000 0,01559761 0,07030436 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01559761 0,07017488 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01559761 0,07004589 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01559761 0,06991736 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01559761 0,06978931 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,01559761 0,06966172 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01559761 0,0695346 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01559761 0,06940795 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01559761 0,06928175 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01559761 0,06915601 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01559761 0,06903073 ! malate metabolic process GO:0006108 13 6 0,000 0,01559761 0,0689059 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01559761 0,06878152 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01559761 0,06865759 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01559761 0,0685341 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01559761 0,06841106 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01559761 0,06828846 ! opsonization GO:0008228 8 6 0,000 0,01559761 0,0681663 ! mating behavior GO:0007617 7 6 0,000 0,01559761 0,06804458 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01559761 0,06792328 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01559761 0,06780242 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01559761 0,06768199 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01559761 0,06756199 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01559761 0,06744241 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01559761 0,06732325 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01559761 0,06720452 ! toxin metabolic process GO:0009404 11 6 0,000 0,01559761 0,0670862 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01559761 0,0669683 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01559761 0,06685081 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01559761 0,06673373 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01559761 0,06661707 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01559761 0,06650081 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01559761 0,06638495 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,01559761 0,0662695 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01559761 0,06615445 ! thymic T cell selection GO:0045061 16 6 0,000 0,01559761 0,0660398 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01559761 0,06592554 ! protein lipoylation GO:0009249 10 6 0,000 0,01559761 0,06581168 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01559761 0,06569821 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01559761 0,06558513 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01559761 0,06547244 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01559761 0,06536014 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01559761 0,06524822 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01559761 0,06513669 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01559761 0,06502553 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01559761 0,06491476 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01559761 0,06480436 ! hyperosmotic response GO:0006972 10 6 0,000 0,01559761 0,06469433 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01559761 0,06458468 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01559761 0,0644754 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01559761 0,06436649 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01559761 0,06425795 ! urea metabolic process GO:0019627 7 6 0,000 0,01559761 0,06414977 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01559761 0,06404195 ! neutrophil activation GO:0042119 7 6 0,000 0,01559761 0,0639345 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01559761 0,06382741 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01559761 0,06372067 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01559761 0,06361429 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01559761 0,06350827 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01559761 0,0634026 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01559761 0,06329728 ! neuron apoptosis GO:0051402 15 6 0,000 0,01559761 0,06319231 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01559761 0,06308769 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01559761 0,06298341 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01559761 0,06287948 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01559761 0,06277589 ! carnitine transport GO:0015879 10 6 0,000 0,01559761 0,06267264 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01559761 0,06256972 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01559761 0,06246715 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01559761 0,06236491 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01559761 0,06226301 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01559761 0,06216144 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01559761 0,0620602 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01559761 0,06195929 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01559761 0,06185871 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01559761 0,06175845 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01559761 0,06165852 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01559761 0,06155891 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,01559761 0,06145962 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,01559761 0,06136065 ! response to UV-C GO:0010225 14 6 0,000 0,01559761 0,061262 ! astrocyte development GO:0014002 16 6 0,000 0,01559761 0,06116366 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01559761 0,06106564 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01559761 0,06096794 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01559761 0,06087055 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01559761 0,06077346 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01559761 0,06067669 ! response to copper ion GO:0046688 10 6 0,000 0,01559761 0,06058023 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01559761 0,06048407 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01559761 0,06038821 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01559761 0,06029266 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01559761 0,06019741 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01559761 0,06010246 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01559761 0,06000781 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01559761 0,05991346 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01559761 0,05981941 ! hair follicle maturation GO:0048820 8 6 0,000 0,01559761 0,05972565 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01559761 0,05963218 ! Schwann cell development GO:0014044 15 6 0,000 0,01559761 0,059539 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01559761 0,05944612 ! response to pheromone GO:0019236 6 6 0,000 0,01559761 0,05935352 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01559761 0,05926122 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01559761 0,0591692 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01559761 0,05907746 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01559761 0,05898601 ! subpallium development GO:0021544 15 6 0,000 0,01559761 0,05889484 ! neural tube patterning GO:0021532 8 6 0,000 0,01559761 0,05880395 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01559761 0,05871335 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01559761 0,05862302 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01559761 0,05853297 ! G2 phase GO:0051319 16 6 0,000 0,01559761 0,05844319 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01559761 0,05835369 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01559761 0,05826447 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01559761 0,05817551 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01559761 0,05808683 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01559761 0,05799842 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01559761 0,05791028 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01559761 0,0578224 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01559761 0,05773479 ! receptor internalization GO:0031623 11 6 0,000 0,01559761 0,05764745 ! plasminogen activation GO:0031639 9 6 0,000 0,01559761 0,05756037 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01559761 0,05747355 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01559761 0,05738699 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01559761 0,0573007 ! protein deubiquitination GO:0016579 16 6 0,000 0,01559761 0,05721466 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,01559761 0,05712888 ! protein destabilization GO:0031648 9 6 0,000 0,01559761 0,05704336 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01559761 0,05695809 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01559761 0,05687308 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01559761 0,05678832 ! progesterone metabolic process GO:0042448 12 6 0,000 0,01559761 0,05670381 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01559761 0,05661956 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01559761 0,05653555 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01559761 0,0564518 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01559761 0,05636829 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01559761 0,05628503 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01559761 0,05620201 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01559761 0,05611924 ! neural plate development GO:0001840 9 6 0,000 0,01559761 0,05603671 ! catecholamine transport GO:0051937 9 6 0,000 0,01559761 0,05595442 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01559761 0,05587238 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01559761 0,05579057 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01559761 0,05570901 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01559761 0,05562768 ! maternal placenta development GO:0001893 12 6 0,000 0,01559761 0,05554659 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01559761 0,05546574 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01559761 0,05538512 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01559761 0,05530473 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01559761 0,05522458 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01559761 0,05514466 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01559761 0,05506497 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01559761 0,05498552 GO:0055081|anion homeostasis, ! humoral immune response GO:0006959 115 73 1,000 0,01577822 0,05554207 ! acute inflammatory response GO:0002526 118 74 1,000 0,01618921 0,05690683 ! respiratory system development GO:0060541 175 74 1,000 0,01618921 0,05682506 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,01660476 0,05820005 GO:0090046|regulation of transcription regulator activity, ! leukocyte mediated immunity GO:0002443 136 75 1,000 0,01660476 0,05811667 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,01702485 0,05950172 ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,01744944 0,06089855 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,01744944 0,06081167 ! regulation of catabolic process GO:0009894 173 77 1,000 0,01744944 0,06072505 ! antigen processing and presentation GO:0019882 117 78 1,000 0,01787852 0,06212976 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,01787852 0,0620415 ! tRNA transcription GO:0009304 17 7 0,000 0,01817371 0,06297642 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,01817371 0,06288721 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,01817371 0,06279826 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01817371 0,06270957 ! regulation of helicase activity GO:0051095 16 7 0,000 0,01817371 0,06262112 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,01817371 0,06253292 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,01817371 0,06244497 ! sleep GO:0030431 16 7 0,000 0,01817371 0,06235727 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01817371 0,06226981 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,01817371 0,0621826 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01817371 0,06209563 ! prostate gland development GO:0030850 14 7 0,000 0,01817371 0,0620089 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,01817371 0,06192242 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01817371 0,06183617 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01817371 0,06175017 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,01817371 0,06166441 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01817371 0,06157888 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,01817371 0,06149359 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,01817371 0,06140854 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01817371 0,06132372 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,01817371 0,06123914 ! glycolipid transport GO:0046836 11 7 0,000 0,01817371 0,06115478 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01817371 0,06107066 GO:0051923|sulfation, ! regulation of protein export from nucleus GO:0046825 10 7 0,000 0,01817371 0,06098678 ! neuron adhesion GO:0007158 14 7 0,000 0,01817371 0,06090312 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,01817371 0,06081969 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,01817371 0,06073649 ! mRNA stabilization GO:0048255 18 7 0,000 0,01817371 0,06065352 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,01817371 0,06057077 ! fibril organization GO:0043206 17 7 0,000 0,01817371 0,06048825 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,01817371 0,06040595 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,01817371 0,06032388 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01817371 0,06024203 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01817371 0,0601604 ! lipoprotein transport GO:0042953 14 7 0,000 0,01817371 0,06007899 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,01817371 0,0599978 ! rhythmic behavior GO:0007622 17 7 0,000 0,01817371 0,05991683 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,01817371 0,05983608 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,01817371 0,05975555 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,01817371 0,05967523 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,01817371 0,05959513 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01817371 0,05951525 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,01817371 0,05943557 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01817371 0,05935611 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,01817371 0,05927687 ! mechanosensory behavior GO:0007638 16 7 0,000 0,01817371 0,05919783 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,01817371 0,05911901 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,01817371 0,05904039 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,01817371 0,05896198 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,01817371 0,05888378 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01817371 0,05880579 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01817371 0,05872801 ! spinal cord patterning GO:0021511 14 7 0,000 0,01817371 0,05865043 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,01817371 0,05857305 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,01817371 0,05849588 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01817371 0,05841891 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,01817371 0,05834215 ! adrenal gland development GO:0030325 17 7 0,000 0,01817371 0,05826558 ! cysteine metabolic process GO:0006534 13 7 0,000 0,01817371 0,05818922 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,01817371 0,05811305 ! ovulation GO:0030728 10 7 0,000 0,01817371 0,05803709 ! adenohypophysis development GO:0021984 11 7 0,000 0,01817371 0,05796132 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,01817371 0,05788575 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,01817371 0,05781038 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,01817371 0,05773521 ! microtubule nucleation GO:0007020 21 7 0,000 0,01817371 0,05766023 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01817371 0,05758544 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,01817371 0,05751085 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01817371 0,05743645 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,01817371 0,05736224 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,01817371 0,05728822 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01817371 0,0572144 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,01817371 0,05714076 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,01817371 0,05706732 ! galactose metabolic process GO:0006012 13 7 0,000 0,01817371 0,05699406 ! response to dietary excess GO:0002021 8 7 0,000 0,01817371 0,05692099 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01817371 0,05684811 ! intracellular pH reduction GO:0051452 13 7 0,000 0,01817371 0,05677541 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01817371 0,0567029 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,01817371 0,05663058 ! organ growth GO:0035265 15 7 0,000 0,01817371 0,05655844 ! nucleoside transport GO:0015858 11 7 0,000 0,01817371 0,05648648 ! nucleoside salvage GO:0043174 11 7 0,000 0,01817371 0,05641471 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,01817371 0,05634311 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,01817371 0,0562717 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,01817371 0,05620047 ! parturition GO:0007567 16 7 0,000 0,01817371 0,05612942 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,01817371 0,05605855 ! rRNA modification GO:0000154 14 7 0,000 0,01817371 0,05598786 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,01817371 0,05591735 ! spindle checkpoint GO:0031577 16 7 0,000 0,01817371 0,05584701 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,01817371 0,05577685 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,01817371 0,05570687 ! monocyte differentiation GO:0030224 16 7 0,000 0,01817371 0,05563706 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,01817371 0,05556743 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01817371 0,05549797 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,01817371 0,05542868 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,01817371 0,05535957 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,01817371 0,05529063 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01817371 0,05522186 ! fibrinolysis GO:0042730 11 7 0,000 0,01817371 0,05515326 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,01817371 0,05508483 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,01817371 0,05501657 ! eating behavior GO:0042755 8 7 0,000 0,01817371 0,05494848 ! B cell lineage commitment GO:0002326 21 7 0,000 0,01817371 0,05488056 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01817371 0,05481281 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,01817371 0,05474522 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,01817371 0,0546778 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,01817371 0,05461055 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,01817371 0,05454346 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01817371 0,05447653 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,01817371 0,05440977 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,01817371 0,05434317 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,01817371 0,05427674 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,01817371 0,05421047 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01817371 0,05414436 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,01817371 0,05407841 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,01817371 0,05401262 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01817371 0,05394699 ! histone ubiquitination GO:0016574 9 7 0,000 0,01817371 0,05388152 ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,01817371 0,05381621 ! T cell lineage commitment GO:0002360 16 7 0,000 0,01817371 0,05375106 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,01817371 0,05368606 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01817371 0,05362122 ! membrane to membrane docking GO:0022614 14 7 0,000 0,01817371 0,05355654 ! transcription termination GO:0006353 14 7 0,000 0,01817371 0,05349202 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01817371 0,05342765 ! anaphase GO:0051322 18 7 0,000 0,01817371 0,05336343 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,01817371 0,05329937 ! axonal fasciculation GO:0007413 19 7 0,000 0,01817371 0,05323546 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,01817371 0,0531717 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,01817371 0,0531081 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,01817371 0,05304465 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,01817371 0,05298135 ! diuresis GO:0030146 12 7 0,000 0,01817371 0,0529182 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01817371 0,05285521 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01817371 0,05279236 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01817371 0,05272966 ! antibiotic transport GO:0042891 9 7 0,000 0,01817371 0,05266711 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01817371 0,05260471 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,01817371 0,05254245 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,01817371 0,05248035 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,01817371 0,05241839 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,01817371 0,05235657 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,01817371 0,0522949 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,01817371 0,05223338 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01817371 0,052172 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01817371 0,05211077 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,01817371 0,05204968 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,01817371 0,05198873 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,01817371 0,05192792 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,01817371 0,05186726 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,01817371 0,05180674 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,01817371 0,05174636 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,01817371 0,05168612 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,01817371 0,05162602 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,01817371 0,05156605 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01817371 0,05150623 ! muscle adaptation GO:0043500 13 7 0,000 0,01817371 0,05144655 ! embryonic heart tube development GO:0035050 14 7 0,000 0,01817371 0,05138701 ! retina homeostasis GO:0001895 12 7 0,000 0,01817371 0,0513276 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,01817371 0,05126833 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,01817371 0,0512092 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,01817371 0,0511502 ! blood coagulation GO:0007596 151 79 1,000 0,01831205 0,05148026 GO:0050817|coagulation, ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,01919239 0,05389311 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,01963914 0,0550843 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,02009025 0,05628495 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02074314 0,05804753 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02074314 0,05798111 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02074314 0,05791485 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02074314 0,05784873 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02074314 0,05778277 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02074314 0,05771696 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02074314 0,0576513 ! male meiosis GO:0007140 9 8 0,000 0,02074314 0,05758579 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02074314 0,05752042 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02074314 0,05745521 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02074314 0,05739014 ! meiotic prophase I GO:0007128 14 8 0,000 0,02074314 0,05732522 ! response to zinc ion GO:0010043 12 8 0,000 0,02074314 0,05726044 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02074314 0,05719581 ! oligopeptide transport GO:0006857 16 8 0,000 0,02074314 0,05713133 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02074314 0,05706699 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02074314 0,0570028 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02074314 0,05693875 ! signal peptide processing GO:0006465 12 8 0,000 0,02074314 0,05687485 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02074314 0,05681109 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02074314 0,05674747 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02074314 0,05668399 ! succinate metabolic process GO:0006105 17 8 0,000 0,02074314 0,05662066 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02074314 0,05655747 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02074314 0,05649442 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02074314 0,05643151 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02074314 0,05636873 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02074314 0,0563061 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,02074314 0,05624361 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02074314 0,05618125 GO:0032107|regulation of response to nutrient levels, ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02074314 0,05611904 ! reflex GO:0060004 17 8 0,000 0,02074314 0,05605696 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02074314 0,05599502 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02074314 0,05593321 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02074314 0,05587155 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02074314 0,05581001 ! pigment granule organization GO:0048753 17 8 0,000 0,02074314 0,05574862 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,02074314 0,05568735 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02074314 0,05562623 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02074314 0,05556523 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02074314 0,05550437 ! histidine catabolic process GO:0006548 10 8 0,000 0,02074314 0,05544364 GO:0009077|histidine family amino acid catabolic process, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02074314 0,05538305 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02074314 0,05532259 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,02074314 0,05526226 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02074314 0,05520206 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02074314 0,05514199 ! melanin metabolic process GO:0006582 17 8 0,000 0,02074314 0,05508206 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02074314 0,05502225 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02074314 0,05496257 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02074314 0,05490302 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,02074314 0,05484361 ! macrophage activation GO:0042116 13 8 0,000 0,02074314 0,05478432 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02074314 0,05472515 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02074314 0,05466612 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02074314 0,05460721 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02074314 0,05454843 ! purine salvage GO:0043101 12 8 0,000 0,02074314 0,05448978 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02074314 0,05443125 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02074314 0,05437284 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02074314 0,05431457 ! osteoblast development GO:0002076 17 8 0,000 0,02074314 0,05425641 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02074314 0,05419839 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02074314 0,05414048 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,02074314 0,0540827 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02074314 0,05402504 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02074314 0,05396751 ! response to UV-B GO:0010224 17 8 0,000 0,02074314 0,0539101 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02074314 0,05385281 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02074314 0,05379564 ! intermediate filament organization GO:0045109 12 8 0,000 0,02074314 0,05373859 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02074314 0,05368166 ! cellular extravasation GO:0045123 13 8 0,000 0,02074314 0,05362486 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02074314 0,05356817 ! response to antibiotic GO:0046677 11 8 0,000 0,02074314 0,05351161 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02074314 0,05345516 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02074314 0,05339883 ! DNA topological change GO:0006265 12 8 0,000 0,02074314 0,05334262 ! response to tropane GO:0014073 15 8 0,000 0,02074314 0,05328653 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,02074314 0,05323056 ! melanosome transport GO:0032402 13 8 0,000 0,02074314 0,0531747 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02074314 0,05311896 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02074314 0,05306334 ! mast cell activation GO:0045576 14 8 0,000 0,02074314 0,05300784 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02074314 0,05295245 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,02074314 0,05289717 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02074314 0,05284201 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02074314 0,05278697 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02074314 0,05273204 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02074314 0,05267723 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02074314 0,05262252 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02074314 0,05256794 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02074314 0,05251346 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02074314 0,0524591 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02074314 0,05240485 ! response to tumor cell GO:0002347 16 8 0,000 0,02074314 0,05235071 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02074314 0,05229669 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02074314 0,05224277 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02074314 0,05218897 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02074314 0,05213528 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02074314 0,0520817 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02074314 0,05202823 ! hormone catabolic process GO:0042447 17 8 0,000 0,02074314 0,05197486 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02074314 0,05192161 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02074314 0,05186847 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02074314 0,05181543 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02074314 0,0517625 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02074314 0,05170969 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02074314 0,05165697 ! adult feeding behavior GO:0008343 10 8 0,000 0,02074314 0,05160437 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02074314 0,05155187 ! ATP catabolic process GO:0006200 11 8 0,000 0,02074314 0,05149948 ! blastocyst growth GO:0001832 19 8 0,000 0,02074314 0,0514472 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02074314 0,05139502 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02074314 0,05134295 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02074314 0,05129098 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02074314 0,05123912 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02074314 0,05118737 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02074314 0,05113571 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02074314 0,05108416 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02074314 0,05103272 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02074314 0,05098138 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02074314 0,05093014 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,02074314 0,05087901 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02074314 0,05082798 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02074314 0,05077705 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02074314 0,05072622 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02074314 0,05067549 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02074314 0,05062487 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,02074314 0,05057434 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02074314 0,05052392 ! hemostasis GO:0007599 165 85 1,000 0,02100542 0,05111181 ! negative regulation of growth GO:0045926 168 85 1,000 0,02100542 0,05106095 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,02100542 0,05101019 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,02146944 0,05208526 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 159 87 1,000 0,02193772 0,0531685 ! regulation of protein transport GO:0051223 165 87 1,000 0,02193772 0,0531158 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 167 89 1,000 0,02288693 0,05535918 ! axon extension GO:0048675 16 9 0,000 0,02330592 0,05631687 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02330592 0,05626122 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02330592 0,05620568 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,02330592 0,05615026 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,02330592 0,05609493 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02330592 0,05603972 ! reproductive behavior GO:0019098 22 9 0,000 0,02330592 0,05598462 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02330592 0,05592963 ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02330592 0,05587474 ! UTP metabolic process GO:0046051 10 9 0,000 0,02330592 0,05581996 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02330592 0,05576529 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,02330592 0,05571072 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02330592 0,05565626 ! artery development GO:0060840 25 9 0,000 0,02330592 0,05560191 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02330592 0,05554767 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,02330592 0,05549353 ! equilibrioception GO:0050957 20 9 0,000 0,02330592 0,05543949 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,02330592 0,05538556 ! chemosensory behavior GO:0007635 21 9 0,000 0,02330592 0,05533174 ! microtubule bundle formation GO:0001578 22 9 0,000 0,02330592 0,05527802 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,02330592 0,0552244 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02330592 0,05517089 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02330592 0,05511748 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02330592 0,05506418 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02330592 0,05501097 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02330592 0,05495788 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02330592 0,05490488 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02330592 0,05485198 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02330592 0,05479919 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02330592 0,0547465 ! protein targeting to ER GO:0045047 25 9 0,000 0,02330592 0,05469391 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02330592 0,05464142 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02330592 0,05458903 ! T cell selection GO:0045058 27 9 0,000 0,02330592 0,05453674 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02330592 0,05448455 ! glycine catabolic process GO:0006546 15 9 0,000 0,02330592 0,05443247 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,02330592 0,05438048 ! endosome organization GO:0007032 20 9 0,000 0,02330592 0,05432859 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02330592 0,0542768 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,02330592 0,0542251 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02330592 0,05417351 ! mannose metabolic process GO:0006013 13 9 0,000 0,02330592 0,05412201 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02330592 0,05407062 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02330592 0,05401932 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,02330592 0,05396811 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02330592 0,05391701 ! receptor clustering GO:0043113 20 9 0,000 0,02330592 0,053866 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02330592 0,05381508 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02330592 0,05376427 ! retinol metabolic process GO:0042572 20 9 0,000 0,02330592 0,05371355 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02330592 0,05366292 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02330592 0,05361239 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02330592 0,05356196 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02330592 0,05351162 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,02330592 0,05346137 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02330592 0,05341122 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02330592 0,05336116 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02330592 0,0533112 ! response to amine stimulus GO:0014075 13 9 0,000 0,02330592 0,05326133 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02330592 0,05321155 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02330592 0,05316187 ! erythrocyte development GO:0048821 17 9 0,000 0,02330592 0,05311227 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02330592 0,05306278 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02330592 0,05301337 ! renal water homeostasis GO:0003091 15 9 0,000 0,02330592 0,05296405 ! postreplication repair GO:0006301 25 9 0,000 0,02330592 0,05291483 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02330592 0,0528657 ! icosanoid secretion GO:0032309 15 9 0,000 0,02330592 0,05281666 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02330592 0,05276771 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02330592 0,05271885 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02330592 0,05267008 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02330592 0,0526214 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02330592 0,05257282 ! sterol catabolic process GO:0016127 14 9 0,000 0,02330592 0,05252432 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02330592 0,05247591 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02330592 0,05242759 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,02330592 0,05237935 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02330592 0,05233121 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02330592 0,05228316 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,02330592 0,05223519 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02330592 0,05218731 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,02330592 0,05213952 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,02330592 0,05209182 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02330592 0,0520442 ! purine base metabolic process GO:0006144 25 9 0,000 0,02330592 0,05199667 ! pigment granule transport GO:0051904 17 9 0,000 0,02330592 0,05194923 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,02330592 0,05190188 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02330592 0,05185461 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02330592 0,05180742 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02330592 0,05176033 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02330592 0,05171331 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02330592 0,05166639 ! mitochondrion localization GO:0051646 18 9 0,000 0,02330592 0,05161955 ! response to unfolded protein GO:0006986 139 90 1,000 0,02336782 0,05170976 ! ossification GO:0001503 205 91 1,000 0,02385286 0,05273533 ! gland development GO:0048732 220 91 1,000 0,02385286 0,05268765 ! bone development GO:0060348 206 92 1,000 0,02434203 0,05371959 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,02434203 0,05367111 ! regulation of membrane potential GO:0042391 179 94 1,000 0,02533267 0,05580498 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,02583409 0,05685827 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02586206 0,0568686 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02586206 0,05681746 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02586206 0,05676641 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02586206 0,05671545 ! associative learning GO:0008306 21 10 0,000 0,02586206 0,05666459 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02586206 0,05661381 ! phosphate transport GO:0006817 24 10 0,000 0,02586206 0,05656313 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02586206 0,05651254 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02586206 0,05646203 ! CTP metabolic process GO:0046036 11 10 0,000 0,02586206 0,05641162 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02586206 0,0563613 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02586206 0,05631107 ! GTP metabolic process GO:0046039 11 10 0,000 0,02586206 0,05626092 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02586206 0,05621087 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02586206 0,0561609 ! social behavior GO:0035176 29 10 0,000 0,02586206 0,05611103 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02586206 0,05606124 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,02586206 0,05601154 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02586206 0,05596193 ! androgen metabolic process GO:0008209 17 10 0,000 0,02586206 0,0559124 ! phospholipid efflux GO:0033700 19 10 0,000 0,02586206 0,05586297 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02586206 0,05581362 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02586206 0,05576436 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02586206 0,05571518 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02586206 0,05566609 ! lung alveolus development GO:0048286 26 10 0,000 0,02586206 0,05561709 ! pathogenesis GO:0009405 17 10 0,000 0,02586206 0,05556818 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02586206 0,05551935 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02586206 0,0554706 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02586206 0,05542194 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,02586206 0,05537337 ! endoderm development GO:0007492 18 10 0,000 0,02586206 0,05532488 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02586206 0,05527648 ! arginine catabolic process GO:0006527 17 10 0,000 0,02586206 0,05522816 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02586206 0,05517993 ! proline metabolic process GO:0006560 13 10 0,000 0,02586206 0,05513178 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02586206 0,05508371 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02586206 0,05503573 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02586206 0,05498783 ! V(D)J recombination GO:0033151 34 10 0,000 0,02586206 0,05494001 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02586206 0,05489228 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,02586206 0,05484463 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02586206 0,05479707 ! B cell proliferation GO:0042100 19 10 0,000 0,02586206 0,05474958 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02586206 0,05470218 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02586206 0,05465486 ! multicellular organism growth GO:0035264 19 10 0,000 0,02586206 0,05460762 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02586206 0,05456046 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02586206 0,05451339 ! ruffle organization GO:0031529 17 10 0,000 0,02586206 0,05446639 ! epithelial cell development GO:0002064 21 10 0,000 0,02586206 0,05441948 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02586206 0,05437265 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02586206 0,0543259 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02586206 0,05427922 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02586206 0,05423263 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02586206 0,05418612 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02586206 0,05413969 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,02586206 0,05409334 ! motor axon guidance GO:0008045 22 10 0,000 0,02586206 0,05404706 ! copper ion homeostasis GO:0055070 13 10 0,000 0,02586206 0,05400087 ! regulation of bone resorption GO:0045124 25 10 0,000 0,02586206 0,05395475 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,02586206 0,05390872 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,02586206 0,05386276 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02586206 0,05381688 ! segment specification GO:0007379 15 10 0,000 0,02586206 0,05377108 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02586206 0,05372535 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02586206 0,05367971 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02586206 0,05363414 ! response to dsRNA GO:0043331 23 10 0,000 0,02586206 0,05358865 ! DNA ligation GO:0006266 18 10 0,000 0,02586206 0,05354323 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02586206 0,0534979 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02586206 0,05345264 ! melanosome localization GO:0032400 16 10 0,000 0,02586206 0,05340745 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02586206 0,05336235 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02586206 0,05331731 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,02586206 0,05327236 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02586206 0,05322748 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,02586206 0,05318267 ! induction of an organ GO:0001759 17 10 0,000 0,02586206 0,05313795 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02586206 0,05309329 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02586206 0,05304871 ! protein sumoylation GO:0016925 17 10 0,000 0,02586206 0,05300421 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02586206 0,05295978 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02586206 0,05291542 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02586206 0,05287114 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02586206 0,05282694 ! salivary gland development GO:0007431 28 10 0,000 0,02586206 0,0527828 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02586206 0,05273875 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02586206 0,05269476 ! midbrain development GO:0030901 14 10 0,000 0,02586206 0,05265085 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02586206 0,05260701 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02586206 0,05256324 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02586206 0,05251955 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02586206 0,05247593 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02586206 0,05243238 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02586206 0,0523889 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02586206 0,0523455 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02586206 0,05230217 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02586206 0,05225891 ! detection of calcium ion GO:0005513 24 10 0,000 0,02586206 0,05221572 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02586206 0,0521726 ! blastocyst formation GO:0001825 18 10 0,000 0,02586206 0,05212955 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02586206 0,05208658 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02586206 0,05204367 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02586206 0,05200084 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02586206 0,05195807 ! response to nicotine GO:0035094 20 10 0,000 0,02586206 0,05191538 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02586206 0,05187276 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,02586206 0,0518302 ! response to protein stimulus GO:0051789 158 96 1,000 0,02633954 0,05274385 ! regulation of protein localization GO:0032880 188 97 1,000 0,026849 0,05372 ! mRNA transport GO:0051028 185 100 1,000 0,0284012 0,05677917 ! positive regulation of immune response GO:0050778 175 100 1,000 0,0284012 0,05673274 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,02841159 0,05670711 ! respiratory burst GO:0045730 17 11 0,000 0,02841159 0,05666082 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,02841159 0,05661461 ! neuron fate specification GO:0048665 18 11 0,000 0,02841159 0,05656847 ! telencephalon cell migration GO:0022029 23 11 0,000 0,02841159 0,0565224 ! thyroid gland development GO:0030878 26 11 0,000 0,02841159 0,05647641 ! synapsis GO:0007129 14 11 0,000 0,02841159 0,05643049 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,02841159 0,05638465 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,02841159 0,05633889 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,02841159 0,05629319 ! response to pain GO:0048265 27 11 0,000 0,02841159 0,05624757 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,02841159 0,05620203 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,02841159 0,05615656 ! blood vessel remodeling GO:0001974 30 11 0,000 0,02841159 0,05611116 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,02841159 0,05606584 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,02841159 0,05602059 ! bone resorption GO:0045453 16 11 0,000 0,02841159 0,05597541 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,02841159 0,0559303 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,02841159 0,05588527 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,02841159 0,05584031 ! melanocyte differentiation GO:0030318 20 11 0,000 0,02841159 0,05579542 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,02841159 0,05575061 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,02841159 0,05570586 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,02841159 0,05566119 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,02841159 0,05561659 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,02841159 0,05557206 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,02841159 0,05552761 ! UV protection GO:0009650 20 11 0,000 0,02841159 0,05548322 ! adult heart development GO:0007512 16 11 0,000 0,02841159 0,0554389 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,02841159 0,05539466 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,02841159 0,05535048 ! macroautophagy GO:0016236 19 11 0,000 0,02841159 0,05530638 ! temperature homeostasis GO:0001659 18 11 0,000 0,02841159 0,05526235 ! behavioral fear response GO:0001662 27 11 0,000 0,02841159 0,05521838 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,02841159 0,05517449 ! negative regulation of ossification GO:0030279 27 11 0,000 0,02841159 0,05513066 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,02841159 0,05508691 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,02841159 0,05504323 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,02841159 0,05499961 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,02841159 0,05495606 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,02841159 0,05491258 ! regulation of organ growth GO:0046620 14 11 0,000 0,02841159 0,05486918 ! pigment granule localization GO:0051875 20 11 0,000 0,02841159 0,05482583 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,02841159 0,05478256 ! vasoconstriction GO:0042310 20 11 0,000 0,02841159 0,05473936 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,02841159 0,05469622 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,02841159 0,05465315 ! embryonic axis specification GO:0000578 19 11 0,000 0,02841159 0,05461015 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,02841159 0,05456722 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,02841159 0,05452436 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,02841159 0,05448156 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,02841159 0,05443883 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,02841159 0,05439617 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,02841159 0,05435357 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,02841159 0,05431104 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,02841159 0,05426857 ! prophase GO:0051324 17 11 0,000 0,02841159 0,05422618 ! neuroblast proliferation GO:0007405 25 11 0,000 0,02841159 0,05418385 ! nucleosome positioning GO:0016584 15 11 0,000 0,02841159 0,05414158 ! regulation of isotype switching GO:0045191 24 11 0,000 0,02841159 0,05409938 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,02841159 0,05405725 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,02841159 0,05401518 ! apical protein localization GO:0045176 18 11 0,000 0,02841159 0,05397318 ! acid secretion GO:0046717 20 11 0,000 0,02841159 0,05393124 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,02841159 0,05388937 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,02841159 0,05384756 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,02841159 0,05380582 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,02841159 0,05376414 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,02841159 0,05372253 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,02841159 0,05368098 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,02841159 0,0536395 ! cholesterol efflux GO:0033344 21 11 0,000 0,02841159 0,05359807 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,02841159 0,05355672 ! oocyte development GO:0048599 20 11 0,000 0,02841159 0,05351543 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,02841159 0,0534742 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,02841159 0,05343303 ! embryonic gut development GO:0048566 19 11 0,000 0,02841159 0,05339193 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,02841159 0,05335089 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,02841159 0,05330991 ! activation of innate immune response GO:0002218 16 11 0,000 0,02841159 0,053269 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,02841159 0,05322815 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,02841159 0,05318736 ! lysogeny GO:0030069 22 11 0,000 0,02841159 0,05314664 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,02841159 0,05310597 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,02841159 0,05306537 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,03095451 0,05777072 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,03095451 0,05772662 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,03095451 0,05768259 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,03095451 0,05763862 ! protein complex disassembly GO:0043241 28 12 0,000 0,03095451 0,05759472 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,03095451 0,05755089 ! hippocampus development GO:0021766 29 12 0,000 0,03095451 0,05750713 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,03095451 0,05746343 ! T cell proliferation GO:0042098 32 12 0,000 0,03095451 0,0574198 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,03095451 0,05737623 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,03095451 0,05733273 ! ventral spinal cord development GO:0021517 25 12 0,000 0,03095451 0,0572893 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,03095451 0,05724593 ! drug transport GO:0015893 16 12 0,000 0,03095451 0,05720263 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,03095451 0,05715939 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,03095451 0,05711622 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,03095451 0,05707311 ! polyamine metabolic process GO:0006595 18 12 0,000 0,03095451 0,05703007 ! focal adhesion formation GO:0048041 37 12 0,000 0,03095451 0,05698709 ! mitotic spindle organization GO:0007052 23 12 0,000 0,03095451 0,05694418 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,03095451 0,05690133 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,03095451 0,05685855 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,03095451 0,05681583 ! lipid digestion GO:0044241 21 12 0,000 0,03095451 0,05677318 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,03095451 0,05673059 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03095451 0,05668806 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,03095451 0,0566456 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,03095451 0,0566032 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,03095451 0,05656086 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,03095451 0,05651859 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,03095451 0,05647638 ! snRNA metabolic process GO:0016073 30 12 0,000 0,03095451 0,05643423 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,03095451 0,05639215 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,03095451 0,05635013 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,03095451 0,05630817 ! cranial nerve development GO:0021545 23 12 0,000 0,03095451 0,05626627 ! fucose catabolic process GO:0019317 25 12 0,000 0,03095451 0,05622444 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,03095451 0,05618267 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,03095451 0,05614096 ! autonomic nervous system development GO:0048483 24 12 0,000 0,03095451 0,05609931 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,03095451 0,05605772 ! zymogen activation GO:0031638 18 12 0,000 0,03095451 0,0560162 ! T cell homeostasis GO:0043029 28 12 0,000 0,03095451 0,05597474 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,03095451 0,05593334 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,03095451 0,055892 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,03095451 0,05585072 ! oocyte differentiation GO:0009994 21 12 0,000 0,03095451 0,0558095 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,03095451 0,05576834 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,03095451 0,05572724 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,03095451 0,05568621 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,03095451 0,05564523 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,03095451 0,05560432 ! defense response to fungus GO:0050832 15 12 0,000 0,03095451 0,05556346 ! developmental induction GO:0031128 22 12 0,000 0,03095451 0,05552267 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,03095451 0,05548193 ! lamellipodium assembly GO:0030032 24 12 0,000 0,03095451 0,05544125 ! response to cold GO:0009409 17 12 0,000 0,03095451 0,05540064 ! establishment of cell polarity GO:0030010 21 12 0,000 0,03095451 0,05536008 ! regulation of synapse organization GO:0050807 18 12 0,000 0,03095451 0,05531958 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,03349085 0,05980859 ! cGMP metabolic process GO:0046068 18 13 0,000 0,03349085 0,0597649 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,03349085 0,05972128 ! regulation of chemokine production GO:0032642 18 13 0,000 0,03349085 0,05967772 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,03349085 0,05963422 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,03349085 0,05959079 ! peroxisomal transport GO:0043574 28 13 0,000 0,03349085 0,05954742 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,03349085 0,05950411 ! cartilage condensation GO:0001502 22 13 0,000 0,03349085 0,05946086 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,03349085 0,05941768 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,03349085 0,05937456 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,03349085 0,05933151 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,03349085 0,05928851 ! endocrine pancreas development GO:0031018 25 13 0,000 0,03349085 0,05924558 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,03349085 0,05920271 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,03349085 0,05915991 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,03349085 0,05911716 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,03349085 0,05907448 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,03349085 0,05903185 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,03349085 0,05898929 ! methionine metabolic process GO:0006555 31 13 0,000 0,03349085 0,05894679 ! plasma membrane organization GO:0007009 27 13 0,000 0,03349085 0,05890435 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,03349085 0,05886198 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,03349085 0,05881966 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,03349085 0,05877741 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,03349085 0,05873521 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,03349085 0,05869308 ! cytokine metabolic process GO:0042107 24 13 0,000 0,03349085 0,058651 ! exocrine system development GO:0035272 34 13 0,000 0,03349085 0,05860899 ! asymmetric protein localization GO:0008105 24 13 0,000 0,03349085 0,05856704 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,03349085 0,05852514 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,03349085 0,05848331 ! L-glutamate transport GO:0015813 30 13 0,000 0,03349085 0,05844153 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,03349085 0,05839982 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,03349085 0,05835817 ! protein homotetramerization GO:0051289 24 13 0,000 0,03349085 0,05831657 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,03349085 0,05827503 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,03349085 0,05823356 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,03349085 0,05819214 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,03349085 0,05815078 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,03349085 0,05810948 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,03349085 0,05806824 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,03349085 0,05802706 ! histone methylation GO:0016571 29 13 0,000 0,03349085 0,05798593 ! chromatin silencing GO:0006342 29 13 0,000 0,03349085 0,05794486 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,03349085 0,05790386 ! regulation of epidermis development GO:0045682 19 13 0,000 0,03349085 0,05786291 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,03349085 0,05782201 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,03349085 0,05778118 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,03349085 0,0577404 ! spleen development GO:0048536 24 13 0,000 0,03349085 0,05769968 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,03349085 0,05765902 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,03349085 0,05761841 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,03349085 0,05757787 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,03349085 0,05753738 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,03349085 0,05749694 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,03349085 0,05745657 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,03349085 0,05741624 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,03349085 0,05737598 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,03349085 0,05733577 ! insulin secretion GO:0030073 24 13 0,000 0,03349085 0,05729562 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,03349085 0,05725553 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,03349085 0,05721549 ! acrosome reaction GO:0007340 19 13 0,000 0,03349085 0,05717551 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,03349085 0,05713558 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,03349085 0,05709571 ! rRNA transcription GO:0009303 28 14 0,000 0,03602062 0,06136568 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,03602062 0,06132292 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,03602062 0,06128021 ! water transport GO:0006833 21 14 0,000 0,03602062 0,06123757 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,03602062 0,06119498 ! non-recombinational repair GO:0000726 29 14 0,000 0,03602062 0,06115246 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,03602062 0,06110999 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,03602062 0,06106758 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,03602062 0,06102523 ! RNA polyadenylation GO:0043631 32 14 0,000 0,03602062 0,06098294 ! palate development GO:0060021 32 14 0,000 0,03602062 0,06094071 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,03602062 0,06089854 ! regulated secretory pathway GO:0045055 24 14 0,000 0,03602062 0,06085642 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,03602062 0,06081436 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,03602062 0,06077236 ! arginine metabolic process GO:0006525 21 14 0,000 0,03602062 0,06073042 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,03602062 0,06068854 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,03602062 0,06064671 ! regulation of heart rate GO:0002027 25 14 0,000 0,03602062 0,06060495 ! fear response GO:0042596 34 14 0,000 0,03602062 0,06056324 ! organic alcohol transport GO:0015850 29 14 0,000 0,03602062 0,06052158 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,03602062 0,06047999 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,03602062 0,06043845 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,03602062 0,06039697 ! neutral amino acid transport GO:0015804 28 14 0,000 0,03602062 0,06035554 ! bone mineralization GO:0030282 18 14 0,000 0,03602062 0,06031418 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,03602062 0,06027287 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,03602062 0,06023161 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,03602062 0,06019041 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,03602062 0,06014927 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,03602062 0,06010819 ! regulation of cellular pH GO:0030641 27 14 0,000 0,03602062 0,06006716 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,03602062 0,06002618 ! ribosome assembly GO:0042255 18 14 0,000 0,03602062 0,05998526 ! cerebellum development GO:0021549 23 14 0,000 0,03602062 0,0599444 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,03602062 0,0599036 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,03602062 0,05986285 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,03602062 0,05982215 ! response to gamma radiation GO:0010332 30 14 0,000 0,03602062 0,05978151 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,03602062 0,05974093 ! NADP metabolic process GO:0006739 24 14 0,000 0,03602062 0,0597004 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,03602062 0,05965992 ! oxygen transport GO:0015671 22 14 0,000 0,03602062 0,0596195 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,03602062 0,05957914 ! male genitalia development GO:0030539 26 14 0,000 0,03602062 0,05953882 ! regulation of RNA stability GO:0043487 33 14 0,000 0,03602062 0,05949857 ! regulation of axon extension GO:0030516 43 14 0,000 0,03602062 0,05945837 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,03602062 0,05941822 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,03602062 0,05937813 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,03854385 0,06349468 ! lactation GO:0007595 30 15 0,000 0,03854385 0,0634519 ! reproductive cellular process GO:0048610 22 15 0,000 0,03854385 0,06340917 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,03854385 0,0633665 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,03854385 0,06332388 ! superoxide anion generation GO:0042554 22 15 0,000 0,03854385 0,06328133 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,03854385 0,06323883 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,03854385 0,06319639 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,03854385 0,063154 ! copper ion transport GO:0006825 22 15 0,000 0,03854385 0,06311167 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,03854385 0,0630694 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,03854385 0,06302719 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,03854385 0,06298503 ! sulfate transport GO:0008272 27 15 0,000 0,03854385 0,06294292 ! response to cAMP GO:0051591 25 15 0,000 0,03854385 0,06290088 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,03854385 0,06285889 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,03854385 0,06281695 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,03854385 0,06277508 ! response to hexose stimulus GO:0009746 25 15 0,000 0,03854385 0,06273325 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,03854385 0,06269149 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,03854385 0,06264978 ! vesicle coating GO:0006901 38 15 0,000 0,03854385 0,06260812 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,03854385 0,06256652 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,03854385 0,06252498 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,03854385 0,06248349 ! regulation of exocytosis GO:0017157 26 15 0,000 0,03854385 0,06244205 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,03854385 0,06240067 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,03854385 0,06235935 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,03854385 0,06231808 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,03854385 0,06227686 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,03854385 0,0622357 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,03854385 0,06219459 ! histone deacetylation GO:0016575 24 15 0,000 0,03854385 0,06215354 ! water homeostasis GO:0030104 28 15 0,000 0,03854385 0,06211254 ! cofactor transport GO:0051181 30 15 0,000 0,03854385 0,0620716 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,03854385 0,06203071 ! muscle maintenance GO:0046716 26 15 0,000 0,03854385 0,06198987 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,03854385 0,06194909 ! intestinal absorption GO:0050892 31 15 0,000 0,03854385 0,06190836 ! dopamine metabolic process GO:0042417 35 15 0,000 0,03854385 0,06186768 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,03854385 0,06182706 ! heme biosynthetic process GO:0006783 33 15 0,000 0,03854385 0,06178649 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,03854385 0,06174598 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,03854385 0,06170551 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,03854385 0,0616651 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,03854385 0,06162475 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,03854385 0,06158444 ! actin filament polymerization GO:0030041 27 15 0,000 0,03854385 0,06154419 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,03854385 0,06150399 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,04106053 0,06547708 ! positive regulation of cell size GO:0045793 29 16 0,000 0,04106053 0,06543437 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,04106053 0,06539171 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,04106053 0,06534911 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,04106053 0,06530657 ! bone remodeling GO:0046849 28 16 0,000 0,04106053 0,06526408 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,04106053 0,06522164 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,04106053 0,06517926 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04106053 0,06513694 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,04106053 0,06509467 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,04106053 0,06505245 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,04106053 0,06501029 ! startle response GO:0001964 28 16 0,000 0,04106053 0,06496819 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,04106053 0,06492614 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,04106053 0,06488414 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,04106053 0,0648422 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,04106053 0,06480031 ! protein polyubiquitination GO:0000209 41 16 0,000 0,04106053 0,06475848 ! glutamate metabolic process GO:0006536 25 16 0,000 0,04106053 0,0647167 ! pituitary gland development GO:0021983 30 16 0,000 0,04106053 0,06467497 ! response to osmotic stress GO:0006970 27 16 0,000 0,04106053 0,0646333 ! lysosomal transport GO:0007041 31 16 0,000 0,04106053 0,06459168 ! fructose metabolic process GO:0006000 25 16 0,000 0,04106053 0,06455012 ! L-amino acid transport GO:0015807 33 16 0,000 0,04106053 0,06450861 ! stem cell development GO:0048864 46 16 0,000 0,04106053 0,06446715 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,04106053 0,06442574 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,04106053 0,06438439 ! intermediate filament-based process GO:0045103 36 16 0,000 0,04106053 0,06434309 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,04106053 0,06430185 ! negative regulation of immune response GO:0050777 38 16 0,000 0,04106053 0,06426066 ! axon cargo transport GO:0008088 46 16 0,000 0,04106053 0,06421952 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,04106053 0,06417843 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,04106053 0,06413739 ! DNA replication initiation GO:0006270 28 16 0,000 0,04106053 0,06409641 ! neuron recognition GO:0008038 40 16 0,000 0,04106053 0,06405548 ! mRNA splice site selection GO:0006376 44 16 0,000 0,04106053 0,0640146 ! tissue regeneration GO:0042246 27 16 0,000 0,04106053 0,06397378 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,04106053 0,063933 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,04106053 0,06389228 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,04106053 0,06385161 ! biomineral formation GO:0031214 22 16 0,000 0,04106053 0,063811 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,04106053 0,06377043 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,04106053 0,06372991 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,04106053 0,06368945 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,04106053 0,06364904 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,04106053 0,06360868 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,04106053 0,06356837 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,04106053 0,06352811 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,04106053 0,0634879 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,04106053 0,06344774 ! peptide hormone processing GO:0016486 27 16 0,000 0,04106053 0,06340764 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,04357071 0,06724146 ! metencephalon development GO:0022037 32 17 0,000 0,04357071 0,06719901 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,04357071 0,06715661 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,04357071 0,06711427 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,04357071 0,06707198 ! signal complex assembly GO:0007172 47 17 0,000 0,04357071 0,06702974 ! endothelial cell migration GO:0043542 31 17 0,000 0,04357071 0,06698756 ! gene silencing by RNA GO:0031047 38 17 0,000 0,04357071 0,06694543 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,04357071 0,06690335 ! glial cell development GO:0021782 28 17 0,000 0,04357071 0,06686133 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,04357071 0,06681936 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,04357071 0,06677744 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,04357071 0,06673557 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,04357071 0,06669376 ! myoblast differentiation GO:0045445 50 17 0,000 0,04357071 0,06665199 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,04357071 0,06661028 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,04357071 0,06656863 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,04357071 0,06652702 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,04357071 0,06648547 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,04357071 0,06644397 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,04357071 0,06640252 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,04357071 0,06636112 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,04357071 0,06631977 ! membrane budding GO:0006900 42 17 0,000 0,04357071 0,06627848 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,04357071 0,06623723 ! regulation of protein binding GO:0043393 33 17 0,000 0,04357071 0,06619604 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,04357071 0,0661549 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,04357071 0,06611381 ! genitalia development GO:0048806 32 17 0,000 0,04357071 0,06607277 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,04357071 0,06603178 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,04357071 0,06599085 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,04357071 0,06594996 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,04357071 0,06590912 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,04357071 0,06586834 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,04357071 0,0658276 ! steroid catabolic process GO:0006706 34 17 0,000 0,04357071 0,06578692 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,04357071 0,06574628 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,04357071 0,0657057 ! gas transport GO:0015669 26 17 0,000 0,04357071 0,06566517 ! organic cation transport GO:0015695 32 17 0,000 0,04357071 0,06562468 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,04357071 0,06558425 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,04357071 0,06554386 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,04357071 0,06550353 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,04607438 0,06922491 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,04607438 0,06918236 ! limbic system development GO:0021761 40 18 0,000 0,04607438 0,06913987 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,04607438 0,06909742 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,04607438 0,06905503 ! adult walking behavior GO:0007628 36 18 0,000 0,04607438 0,06901269 ! patterning of blood vessels GO:0001569 43 18 0,000 0,04607438 0,06897041 ! heart looping GO:0001947 34 18 0,000 0,04607438 0,06892817 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,04607438 0,06888599 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,04607438 0,06884385 ! centrosome cycle GO:0007098 26 18 0,000 0,04607438 0,06880177 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,04607438 0,06875974 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,04607438 0,06871777 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,04607438 0,06867584 ! glycine metabolic process GO:0006544 30 18 0,000 0,04607438 0,06863396 ! glutamine metabolic process GO:0006541 29 18 0,000 0,04607438 0,06859214 ! response to retinoic acid GO:0032526 31 18 0,000 0,04607438 0,06855037 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,04607438 0,06850864 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,04607438 0,06846697 ! DNA integration GO:0015074 32 18 0,000 0,04607438 0,06842535 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,04607438 0,06838378 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,04607438 0,06834226 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,04607438 0,06830079 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,04607438 0,06825937 ! neural crest cell migration GO:0001755 41 18 0,000 0,04607438 0,068218 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,04607438 0,06817668 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,04607438 0,06813541 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,04607438 0,06809419 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,04607438 0,06805302 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,04607438 0,0680119 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,04607438 0,06797083 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,04607438 0,06792981 ! detection of bacterium GO:0016045 22 18 0,000 0,04607438 0,06788884 ! nerve development GO:0021675 34 18 0,000 0,04607438 0,06784792 ! defense response to virus GO:0051607 43 18 0,000 0,04607438 0,06780705 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,04607438 0,06776623 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,04607438 0,06772545 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,04857156 0,07135318 ! positive regulation of translation GO:0045727 31 19 0,000 0,04857156 0,0713103 ! negative regulation of defense response GO:0031348 27 19 0,000 0,04857156 0,07126747 ! neuron maturation GO:0042551 46 19 0,000 0,04857156 0,07122469 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,04857156 0,07118196 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,04857156 0,07113929 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,04857156 0,07109666 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,04857156 0,07105409 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,04857156 0,07101157 ! inositol metabolic process GO:0006020 33 19 0,000 0,04857156 0,0709691 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,04857156 0,07092668 ! memory GO:0007613 34 19 0,000 0,04857156 0,07088431 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,04857156 0,07084199 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,04857156 0,07079972 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,04857156 0,0707575 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,04857156 0,07071533 ! cerebral cortex development GO:0021987 40 19 0,000 0,04857156 0,07067322 ! pigmentation during development GO:0048066 42 19 0,000 0,04857156 0,07063115 ! response to vitamin A GO:0033189 32 19 0,000 0,04857156 0,07058913 ! heme metabolic process GO:0042168 40 19 0,000 0,04857156 0,07054716 ! neuromuscular junction development GO:0007528 43 19 0,000 0,04857156 0,07050525 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,04857156 0,07046338 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,04857156 0,07042156 ! response to fungus GO:0009620 26 19 0,000 0,04857156 0,07037979 ! heart process GO:0003015 32 19 0,000 0,04857156 0,07033807 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,04857156 0,0702964 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,04857156 0,07025478 ! visual learning GO:0008542 38 19 0,000 0,04857156 0,07021321 ! cellular pigmentation GO:0033059 37 19 0,000 0,04857156 0,07017169 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,04857156 0,07013022 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,04857156 0,0700888 ! vitamin transport GO:0051180 31 19 0,000 0,04857156 0,07004742 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,04857156 0,0700061 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,04857156 0,06996482 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,04857156 0,06992359 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,04857156 0,06988241 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,04857156 0,06984128 ! cilium assembly GO:0042384 38 19 0,000 0,04857156 0,06980019 ! peptide hormone secretion GO:0030072 32 19 0,000 0,04857156 0,06975916 ! protein secretion GO:0009306 45 20 0,000 0,05106228 0,07329328 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,05106228 0,07325024 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,05106228 0,07320725 ! positive regulation of ossification GO:0045778 50 20 0,000 0,05106228 0,07316432 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,05106228 0,07312143 ! skin development GO:0043588 42 20 0,000 0,05106228 0,07307859 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,05106228 0,07303581 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,05106228 0,07299307 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,05106228 0,07295039 ! response to vitamin GO:0033273 36 20 0,000 0,05106228 0,07290775 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,05106228 0,07286516 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,05106228 0,07282263 ! bile acid metabolic process GO:0008206 34 20 0,000 0,05106228 0,07278014 ! response to alkaloid GO:0043279 38 20 0,000 0,05106228 0,0727377 ! retinoid metabolic process GO:0001523 34 20 0,000 0,05106228 0,07269532 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,05106228 0,07265298 ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,05106228 0,07261069 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,05106228 0,07256845 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,05106228 0,07252626 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,05106228 0,07248411 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,05106228 0,07244202 ! actin filament bundle formation GO:0051017 47 20 0,000 0,05106228 0,07239998 ! body fluid secretion GO:0007589 33 20 0,000 0,05106228 0,07235798 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,05106228 0,07231604 ! peptide secretion GO:0002790 38 20 0,000 0,05106228 0,07227414 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,05106228 0,07223229 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,05106228 0,07219049 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,05106228 0,07214873 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,05106228 0,07210703 ! cell-cell junction organization GO:0045216 43 20 0,000 0,05106228 0,07206537 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,05106228 0,07202377 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,05106228 0,0719822 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,05106228 0,07194069 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,05106228 0,07189923 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,05106228 0,07185781 ! regulation of glucose import GO:0046324 30 20 0,000 0,05106228 0,07181644 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,05106228 0,07177512 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,05106228 0,07173385 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,05106228 0,07169262 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,05106228 0,07165144 ! regulation of cell killing GO:0031341 46 21 0,000 0,05354655 0,07509428 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,05354655 0,07505119 ! hormone secretion GO:0046879 39 21 0,000 0,05354655 0,07500816 ! cAMP metabolic process GO:0046058 41 21 0,000 0,05354655 0,07496518 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,05354655 0,07492224 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,05354655 0,07487935 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,05354655 0,07483652 ! ovarian follicle development GO:0001541 39 21 0,000 0,05354655 0,07479373 ! smooth muscle contraction GO:0006939 48 21 0,000 0,05354655 0,07475099 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,05354655 0,0747083 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,05354655 0,07466566 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,05354655 0,07462306 ! plasma membrane fusion GO:0045026 33 21 0,000 0,05354655 0,07458052 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,05354655 0,07453802 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,05354655 0,07449558 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,05354655 0,07445318 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,05354655 0,07441083 ! diencephalon development GO:0021536 36 21 0,000 0,05354655 0,07436852 ! collagen fibril organization GO:0030199 62 21 0,000 0,05354655 0,07432627 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,05354655 0,07428406 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,05354655 0,0742419 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,05354655 0,07419979 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,05354655 0,07415773 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,05354655 0,07411571 ! collagen catabolic process GO:0030574 29 21 0,000 0,05354655 0,07407374 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,05354655 0,07403182 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,05354655 0,07398995 ! sperm-egg recognition GO:0035036 23 21 0,000 0,05354655 0,07394812 ! actin filament-based movement GO:0030048 47 21 0,000 0,05354655 0,07390635 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,05354655 0,07386461 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,05602439 0,07723904 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,05602439 0,07719548 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,05602439 0,07715197 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,05602439 0,0771085 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,05602439 0,07706508 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,05602439 0,07702171 ! microtubule-based transport GO:0010970 59 22 0,000 0,05602439 0,0769784 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,05602439 0,07693512 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,05602439 0,0768919 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,05602439 0,07684873 ! cellular response to starvation GO:0009267 37 22 0,000 0,05602439 0,0768056 ! vacuolar transport GO:0007034 41 22 0,000 0,05602439 0,07676253 ! central nervous system neuron development GO:0021954 47 22 0,000 0,05602439 0,0767195 ! fucose metabolic process GO:0006004 44 22 0,000 0,05602439 0,07667652 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,05602439 0,07663359 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,05602439 0,0765907 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,05602439 0,07654787 ! ureteric bud development GO:0001657 50 22 0,000 0,05602439 0,07650508 ! stem cell differentiation GO:0048863 57 22 0,000 0,05602439 0,07646234 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,05602439 0,07641965 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,05602439 0,076377 ! renal system process GO:0003014 42 22 0,000 0,05602439 0,0763344 ! vasodilation GO:0042311 40 22 0,000 0,05602439 0,07629185 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,05602439 0,07624935 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,05602439 0,0762069 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,05602439 0,07616449 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,05602439 0,07612213 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,05602439 0,07607981 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,05602439 0,07603755 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,05602439 0,07599533 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,05602439 0,07595316 ! sarcomere organization GO:0045214 32 22 0,000 0,05602439 0,07591103 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,05602439 0,07586895 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,05602439 0,07582692 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,05602439 0,07578493 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,05602439 0,07574299 ! gut development GO:0048565 44 22 0,000 0,05602439 0,0757011 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,05602439 0,07565925 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,05602439 0,07561745 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,05602439 0,0755757 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,05849581 0,07886604 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,05849581 0,07882254 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,05849581 0,07877909 ! gluconeogenesis GO:0006094 38 23 0,000 0,05849581 0,07873568 ! glycerol metabolic process GO:0006071 40 23 0,000 0,05849581 0,07869232 ! viral genome replication GO:0019079 44 23 0,000 0,05849581 0,07864902 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,05849581 0,07860575 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,05849581 0,07856254 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,05849581 0,07851937 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,05849581 0,07847626 ! regeneration GO:0031099 42 23 0,000 0,05849581 0,07843318 ! axis specification GO:0009798 43 23 0,000 0,05849581 0,07839016 ! visual behavior GO:0007632 46 23 0,000 0,05849581 0,07834718 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,05849581 0,07830425 ! response to ethanol GO:0045471 47 23 0,000 0,05849581 0,07826137 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,05849581 0,07821853 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,05849581 0,07817575 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,05849581 0,078133 ! peroxisome organization GO:0007031 43 23 0,000 0,05849581 0,07809031 ! lysosome organization GO:0007040 47 23 0,000 0,05849581 0,07804766 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,05849581 0,07800506 ! vesicle targeting GO:0006903 49 23 0,000 0,05849581 0,0779625 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,05849581 0,07791999 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,05849581 0,07787753 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,05849581 0,07783511 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,05849581 0,07779274 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,05849581 0,07775041 ! DNA modification GO:0006304 36 23 0,000 0,05849581 0,07770814 ! fatty acid transport GO:0015908 47 23 0,000 0,05849581 0,0776659 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,05849581 0,07762372 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,05849581 0,07758158 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,05849581 0,07753948 ! hormone transport GO:0009914 41 23 0,000 0,05849581 0,07749743 ! cell-cell recognition GO:0009988 28 23 0,000 0,05849581 0,07745543 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,05849581 0,07741347 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,05849581 0,07737155 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,05849581 0,07732969 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,06096083 0,08054478 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,06096083 0,08050124 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,06096083 0,08045775 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,06096083 0,08041431 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,06096083 0,08037091 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,06096083 0,08032756 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,06096083 0,08028426 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,06096083 0,080241 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,06096083 0,08019779 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,06096083 0,08015463 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,06096083 0,08011151 GO:0042278|purine nucleoside metabolic process, ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,06096083 0,08006844 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,06096083 0,08002542 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,06096083 0,07998244 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,06096083 0,07993951 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,06096083 0,07989662 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,06096083 0,07985378 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,06096083 0,07981099 ! pallium development GO:0021543 56 24 0,000 0,06096083 0,07976824 ! oogenesis GO:0048477 44 24 0,000 0,06096083 0,07972554 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,06096083 0,07968288 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,06096083 0,07964027 ! platelet activation GO:0030168 41 24 0,000 0,06096083 0,0795977 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,06096083 0,07955518 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,06096083 0,07951271 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,06096083 0,07947028 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,06096083 0,07942789 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,06096083 0,07938555 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,06096083 0,07934326 ! regulation of amine transport GO:0051952 41 24 0,000 0,06096083 0,07930101 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,06341946 0,08245542 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,06341946 0,08241156 ! leukocyte adhesion GO:0007159 55 25 0,000 0,06341946 0,08236775 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,06341946 0,08232399 ! phototransduction GO:0007602 37 25 0,000 0,06341946 0,08228027 ! keratinization GO:0031424 37 25 0,000 0,06341946 0,08223659 ! vacuole organization GO:0007033 49 25 0,000 0,06341946 0,08219297 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,06341946 0,08214939 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,06341946 0,08210585 ! receptor metabolic process GO:0043112 53 25 0,000 0,06341946 0,08206236 ! chromosome condensation GO:0030261 48 25 0,000 0,06341946 0,08201892 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,06341946 0,08197552 ! regulation of behavior GO:0050795 48 25 0,000 0,06341946 0,08193217 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,06341946 0,08188887 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,06341946 0,08184561 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,06341946 0,0818024 ! immunoglobulin production GO:0002377 62 25 0,000 0,06341946 0,08175923 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,06341946 0,08171611 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,06341946 0,08167303 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,06341946 0,08163 ! liver development GO:0001889 55 25 0,000 0,06341946 0,08158701 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,06587172 0,08469717 ! myelination GO:0042552 50 26 0,000 0,06587172 0,08465262 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,06587172 0,08460811 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,06587172 0,08456365 ! molting cycle process GO:0022404 52 26 0,000 0,06587172 0,08451923 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,06587172 0,08447487 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,06587172 0,08443055 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,06587172 0,08438627 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,06587172 0,08434205 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,06587172 0,08429786 ! digestive system process GO:0022600 49 26 0,000 0,06587172 0,08425373 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,06587172 0,08420964 ! osteoblast differentiation GO:0001649 63 26 0,000 0,06587172 0,0841656 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,06587172 0,0841216 ! neural crest cell development GO:0014032 59 26 0,000 0,06587172 0,08407765 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,06587172 0,08403375 ! negative regulation of cell development GO:0010721 83 26 0,000 0,06587172 0,08398989 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,06587172 0,08394607 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,06587172 0,08390231 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,06587172 0,08385858 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,06587172 0,08381491 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,06587172 0,08377128 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,06587172 0,08372769 ! blastocyst development GO:0001824 50 26 0,000 0,06587172 0,08368415 ! telomere organization GO:0032200 46 26 0,000 0,06587172 0,08364066 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,06587172 0,08359721 ! neural tube closure GO:0001843 58 26 0,000 0,06587172 0,0835538 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,06587172 0,08351044 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,06587172 0,08346713 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,06587172 0,08342386 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,06831764 0,08647668 ! embryonic pattern specification GO:0009880 49 27 0,000 0,06831764 0,08643189 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,06831764 0,08638716 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,06831764 0,08634247 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,06831764 0,08629782 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,06831764 0,08625322 ! iron ion transport GO:0006826 65 27 0,000 0,06831764 0,08620867 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,06831764 0,08616417 ! superoxide metabolic process GO:0006801 41 27 0,000 0,06831764 0,0861197 ! tube lumen formation GO:0035148 59 27 0,000 0,06831764 0,08607529 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,06831764 0,08603092 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,06831764 0,0859866 ! response to starvation GO:0042594 47 27 0,000 0,06831764 0,08594232 ! response to toxin GO:0009636 49 27 0,000 0,06831764 0,08589809 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,06831764 0,0858539 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,06831764 0,08580976 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,06831764 0,08576567 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,06831764 0,08572162 ! leukocyte proliferation GO:0070661 59 27 0,000 0,06831764 0,08567761 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,06831764 0,08563365 ! neuron fate commitment GO:0048663 52 28 0,000 0,07075721 0,08864609 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,07075721 0,08860065 ! circadian rhythm GO:0007623 56 28 0,000 0,07075721 0,08855526 ! dendrite development GO:0016358 67 28 0,000 0,07075721 0,08850992 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,07075721 0,08846462 ! fat cell differentiation GO:0045444 57 28 0,000 0,07075721 0,08841937 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,07075721 0,08837417 ! sperm motility GO:0030317 37 28 0,000 0,07075721 0,08832901 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,07075721 0,0882839 ! base-excision repair GO:0006284 41 28 0,000 0,07075721 0,08823883 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,07075721 0,08819381 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,07075721 0,08814884 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,07075721 0,08810391 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,07075721 0,08805903 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,07075721 0,08801419 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,07075721 0,0879694 ! glutathione metabolic process GO:0006749 42 28 0,000 0,07075721 0,08792466 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,07075721 0,08787996 ! lipid oxidation GO:0034440 48 28 0,000 0,07075721 0,0878353 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,07075721 0,08779069 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,07075721 0,08774613 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,07319047 0,09071757 ! translational initiation GO:0006413 66 29 0,000 0,07319047 0,09067156 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,07319047 0,09062561 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,07319047 0,0905797 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,07319047 0,09053383 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,07319047 0,09048802 ! autophagy GO:0006914 47 29 0,000 0,07319047 0,09044225 ! primary neural tube formation GO:0014020 61 29 0,000 0,07319047 0,09039652 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,07319047 0,09035085 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,07319047 0,09030521 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,07319047 0,09025963 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,07319047 0,09021409 ! synaptogenesis GO:0007416 46 29 0,000 0,07319047 0,09016859 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,07319047 0,09012315 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,07319047 0,09007774 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,07319047 0,09003239 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,07561743 0,092971 ! phenol metabolic process GO:0018958 56 30 0,000 0,07561743 0,09292423 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,07561743 0,09287751 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,07561743 0,09283084 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,07561743 0,09278422 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,07561743 0,09273764 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,07561743 0,09269111 ! acute-phase response GO:0006953 50 30 0,000 0,07561743 0,09264462 ! myofibril assembly GO:0030239 50 30 0,000 0,07561743 0,09259818 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,07561743 0,09255179 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,07561743 0,09250544 ! cell fate determination GO:0001709 64 30 0,000 0,07561743 0,09245915 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,07561743 0,09241289 ! phospholipid transport GO:0015914 65 30 0,000 0,07561743 0,09236669 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,07561743 0,09232053 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,07561743 0,09227441 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,07561743 0,09222834 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,07561743 0,09218232 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,07561743 0,09213635 GO:0048871|multicellular organismal homeostasis, ! alkaloid metabolic process GO:0009820 57 31 0,000 0,07803809 0,09503842 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,07803809 0,09499106 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,07803809 0,09494376 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,07803809 0,0948965 ! cell junction assembly GO:0034329 85 31 0,000 0,07803809 0,09484929 ! regulation of innate immune response GO:0045088 57 31 0,000 0,07803809 0,09480212 ! ovulation cycle process GO:0022602 55 31 0,000 0,07803809 0,094755 ! peptide transport GO:0015833 60 31 0,000 0,07803809 0,09470793 ! male gonad development GO:0008584 56 31 0,000 0,07803809 0,09466091 ! iron ion homeostasis GO:0055072 60 31 0,000 0,07803809 0,09461393 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,07803809 0,094567 ! detection of light stimulus GO:0009583 44 31 0,000 0,07803809 0,09452011 ! natural killer cell activation GO:0030101 50 31 0,000 0,07803809 0,09447327 ! ensheathment of neurons GO:0007272 64 31 0,000 0,07803809 0,09442648 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,07803809 0,09437973 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,07803809 0,09433303 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,07803809 0,09428638 ! eye morphogenesis GO:0048592 65 31 0,000 0,07803809 0,09423977 ! response to heat GO:0009408 54 31 0,000 0,07803809 0,09419321 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,07803809 0,0941467 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,08045249 0,09701157 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,08045249 0,09696371 ! collagen metabolic process GO:0032963 49 32 0,000 0,08045249 0,09691589 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,08045249 0,09686813 ! spindle organization GO:0007051 50 32 0,000 0,08045249 0,09682041 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,08045249 0,09677274 ! metanephros development GO:0001656 81 32 0,000 0,08045249 0,09672511 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,08045249 0,09667754 ! muscle cell development GO:0055001 52 32 0,000 0,08045249 0,09663001 ! mesoderm formation GO:0001707 73 32 0,000 0,08045249 0,09658252 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,08045249 0,09653509 ! ovulation cycle GO:0042698 57 32 0,000 0,08045249 0,09648769 ! peripheral nervous system development GO:0007422 68 32 0,000 0,08045249 0,09644035 ! BMP signaling pathway GO:0030509 71 32 0,000 0,08045249 0,09639305 ! hindbrain development GO:0030902 65 32 0,000 0,08045249 0,0963458 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,08045249 0,0962986 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,08045249 0,09625144 ! gene silencing GO:0016458 71 32 0,000 0,08045249 0,09620432 ! regulation of pH GO:0006885 56 33 0,000 0,08286063 0,09903548 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,08286063 0,09898705 ! pigment biosynthetic process GO:0046148 73 33 0,000 0,08286063 0,09893867 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,08286063 0,09889034 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,08286063 0,09884205 ! response to ionizing radiation GO:0010212 74 33 0,000 0,08286063 0,09879381 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,08286063 0,09874562 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,08286063 0,09869748 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,08286063 0,09864938 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,08286063 0,09860133 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,08286063 0,09855332 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,08286063 0,09850536 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,08286063 0,09845745 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,08526253 0,10126221 ! glial cell differentiation GO:0010001 67 34 0,000 0,08526253 0,10121301 ! post-embryonic development GO:0009791 76 34 0,000 0,08526253 0,10116385 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,08526253 0,10111474 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,08526253 0,10106568 ! spliceosome assembly GO:0000245 75 34 0,000 0,08526253 0,10101667 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,08526253 0,1009677 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,08526253 0,10091878 ! formation of primary germ layer GO:0001704 76 34 0,000 0,08526253 0,10086991 ! cell fate specification GO:0001708 56 34 0,000 0,08526253 0,10082109 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,08526253 0,10077231 ! adult locomotory behavior GO:0008344 62 34 0,000 0,08526253 0,10072358 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,08765821 0,10350363 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,08765821 0,10345363 ! negative regulation of secretion GO:0051048 68 35 0,000 0,08765821 0,10340368 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,08765821 0,10335377 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,08765821 0,10330392 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,08765821 0,10325411 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,08765821 0,10320435 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,08765821 0,10315463 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,08765821 0,10310497 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,08765821 0,10305535 ! ceramide metabolic process GO:0006672 72 35 0,000 0,08765821 0,10300578 ! telencephalon development GO:0021537 81 35 0,000 0,08765821 0,10295626 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,08765821 0,10290678 ! placenta development GO:0001890 53 35 0,000 0,08765821 0,10285736 ! vesicle localization GO:0051648 70 35 0,000 0,08765821 0,10280798 ! regulation of muscle development GO:0048634 82 36 0,000 0,09004769 0,10555974 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,09004769 0,10550911 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,09004769 0,10545853 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,09004769 0,105408 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,09004769 0,10535752 ! positive regulation of cell development GO:0010720 85 36 0,000 0,09004769 0,10530708 ! protein targeting to membrane GO:0006612 75 36 0,000 0,09004769 0,1052567 ! regulation of proteolysis GO:0030162 77 36 0,000 0,09004769 0,10520636 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,09004769 0,10515607 ! aerobic respiration GO:0009060 56 36 0,000 0,09004769 0,10510583 ! cytokine production GO:0001816 68 36 0,000 0,09004769 0,10505563 ! embryonic organ development GO:0048568 67 36 0,000 0,09004769 0,10500549 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,09004769 0,10495539 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,09004769 0,10490534 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,09243097 0,10763053 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,09243097 0,10757925 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,09243097 0,10752803 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,09243097 0,10747685 ! sister chromatid segregation GO:0000819 65 37 0,000 0,09243097 0,10742572 ! odontogenesis GO:0042476 74 37 0,000 0,09243097 0,10737463 ! actomyosin structure organization GO:0031032 68 37 0,000 0,09243097 0,1073236 ! cell junction organization GO:0034330 96 37 0,000 0,09243097 0,10727262 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,09243097 0,10722168 ! female gonad development GO:0008585 71 37 0,000 0,09243097 0,10717079 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,09243097 0,10711995 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,09243097 0,10706916 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,09243097 0,10701841 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,09480807 0,10971868 ! meiosis I GO:0007127 74 38 0,000 0,09480807 0,10966673 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,09480807 0,10961483 ! organic anion transport GO:0015711 82 38 0,000 0,09480807 0,10956297 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,09480807 0,10951117 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,09480807 0,10945942 ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,09480807 0,10940771 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,09480807 0,10935606 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,09480807 0,10930445 ! spermatid development GO:0007286 69 38 0,000 0,09480807 0,10925289 ! glycogen metabolic process GO:0005977 63 38 0,000 0,09480807 0,10920138 ! pigment metabolic process GO:0042440 87 38 0,000 0,09480807 0,10914992 ! neural tube formation GO:0001841 79 38 0,000 0,09480807 0,10909851 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,09717902 0,11177418 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,09717902 0,11172158 ! negative regulation of binding GO:0051100 71 39 0,000 0,09717902 0,11166903 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,09717902 0,11161653 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,09717902 0,11156407 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,09717902 0,11151167 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,09717902 0,11145932 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,09717902 0,11140702 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,09717902 0,11135476 ! glucan metabolic process GO:0044042 64 39 0,000 0,09717902 0,11130256 GO:0006073|cellular glucan metabolic process, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,09954383 0,11395762 ! learning GO:0007612 82 40 0,000 0,09954383 0,11390425 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,09954383 0,11385092 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,09954383 0,11379764 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,09954383 0,11374442 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,09954383 0,11369124 ! RNA export from nucleus GO:0006405 61 41 0,000 0,1019025 0,11633075 ! mRNA catabolic process GO:0006402 79 41 0,000 0,1019025 0,11627642 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,1019025 0,11622213 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,1019025 0,1161679 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,1019025 0,11611372 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,1019025 0,11605959 ! feeding behavior GO:0007631 69 41 0,000 0,1019025 0,1160055 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,1019025 0,11595147 ! mesenchymal cell development GO:0014031 94 41 0,000 0,1019025 0,11589749 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,1019025 0,11584356 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,1019025 0,11578968 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,1019025 0,11573585 ! spermatid differentiation GO:0048515 73 41 0,000 0,1019025 0,11568207 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,1019025 0,11562834 ! RNA modification GO:0009451 64 41 0,000 0,1019025 0,11557466 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,10425506 0,11818799 ! ear morphogenesis GO:0042471 64 42 0,000 0,10425506 0,11813317 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,10425506 0,11807841 ! T cell differentiation GO:0030217 93 42 0,000 0,10425506 0,11802369 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,10425506 0,11796902 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,10425506 0,11791441 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,10425506 0,11785984 ! regulation of protein secretion GO:0050708 77 42 0,000 0,10425506 0,11780533 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,10425506 0,11775087 ! cytokinesis GO:0000910 84 42 0,000 0,10425506 0,11769645 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,10425506 0,11764209 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,10660153 0,12023432 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,10660153 0,12017884 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,10660153 0,12012341 ! regulation of tube size GO:0035150 76 43 0,000 0,10660153 0,12006802 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,10660153 0,12001269 ! glucose transport GO:0015758 66 43 0,000 0,10660153 0,11995741 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,10660153 0,11990218 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,10660153 0,11984701 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,10660153 0,11979188 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,10660153 0,1197368 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,10660153 0,11968178 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,10660153 0,1196268 ! ion transmembrane transport GO:0034220 79 43 0,000 0,10660153 0,11957187 ! neuron migration GO:0001764 85 43 0,000 0,10660153 0,119517 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,10894192 0,12208491 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,10894192 0,12202893 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,10894192 0,12197301 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,10894192 0,12191714 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,10894192 0,12186131 ! hexose transport GO:0008645 68 44 0,000 0,10894192 0,12180554 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,10894192 0,12174982 ! striated muscle contraction GO:0006941 85 44 0,000 0,10894192 0,12169415 ! phagocytosis GO:0006909 105 44 0,000 0,10894192 0,12163853 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,10894192 0,12158296 ! double-strand break repair GO:0006302 85 44 0,000 0,10894192 0,12152745 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,11127624 0,12407478 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,11127624 0,12401818 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! biopolymer methylation GO:0043414 91 45 0,000 0,11127624 0,12396163 ! B cell differentiation GO:0030183 124 45 0,000 0,11127624 0,12390513 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,11127624 0,12384868 ! female gamete generation GO:0007292 71 45 0,000 0,11127624 0,12379228 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,11127624 0,12373594 ! polyol metabolic process GO:0019751 77 45 0,000 0,11127624 0,12367964 ! developmental growth GO:0048589 88 45 0,000 0,11127624 0,1236234 ! maintenance of location in cell GO:0051651 101 45 0,000 0,11127624 0,12356721 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,11360451 0,12609533 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,11360451 0,12603807 ! glycolysis GO:0006096 71 46 0,000 0,11360451 0,12598085 ! leukocyte migration GO:0050900 75 46 0,000 0,11360451 0,12592369 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,11360451 0,12586659 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,11360451 0,12580953 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,11360451 0,12575252 ! pigmentation GO:0043473 103 46 0,000 0,11360451 0,12569557 ! cell growth GO:0016049 90 46 0,000 0,11360451 0,12563867 ! neural tube development GO:0021915 91 47 0,000 0,11592675 0,12814889 ! positive regulation of defense response GO:0031349 88 48 0,000 0,11824297 0,13065019 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,11824297 0,13059112 ! cellular component disassembly GO:0022411 89 48 0,000 0,11824297 0,13053211 ! endosome transport GO:0016197 127 48 0,000 0,11824297 0,13047316 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,11824297 0,13041425 ! male sex differentiation GO:0046661 93 48 0,000 0,11824297 0,1303554 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,11824297 0,1302966 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,11824297 0,13023786 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,11824297 0,13017917 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,11824297 0,13012053 ! methylation GO:0032259 97 48 0,000 0,11824297 0,13006194 ! response to calcium ion GO:0051592 94 49 0,000 0,12055318 0,1325434 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,12055318 0,13248377 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,12055318 0,1324242 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,12055318 0,13236469 ! JNK cascade GO:0007254 106 49 0,000 0,12055318 0,13230522 ! regulation of action potential GO:0001508 102 50 0,000 0,12285741 0,13477353 ! regulation of ion transport GO:0043269 86 50 0,000 0,12285741 0,13471304 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,12285741 0,1346526 ! endocrine system development GO:0035270 109 50 0,000 0,12285741 0,13459222 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,12285741 0,13453189 ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,12285741 0,13447162 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,12285741 0,1344114 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,12285741 0,13435123 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,12515566 0,13680326 ! peptide metabolic process GO:0006518 80 51 0,000 0,12515566 0,13674208 ! response to temperature stimulus GO:0009266 84 51 0,000 0,12515566 0,13668095 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,12515566 0,13661988 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,12515566 0,13655886 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,12744796 0,13899793 ! Notch signaling pathway GO:0007219 111 52 0,000 0,12744796 0,13893591 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,12744796 0,13887394 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,12744796 0,13881203 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,12744796 0,13875017 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,12744796 0,13868836 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,12744796 0,13862661 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,12744796 0,13856492 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,12744796 0,13850328 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,12744796 0,1384417 ! amino acid activation GO:0043038 98 52 0,000 0,12744796 0,13838017 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,12973432 0,14080006 ! inner ear development GO:0048839 89 53 0,000 0,12973432 0,14073754 ! chromatin remodeling GO:0006338 122 53 0,000 0,12973432 0,14067507 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,12973432 0,14061266 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,12973432 0,14055031 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,12973432 0,14048801 ! cartilage development GO:0051216 99 53 0,000 0,12973432 0,14042576 ! synapse organization GO:0050808 102 53 0,000 0,12973432 0,14036357 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,13201475 0,14276761 ! regulation of translational initiation GO:0006446 87 54 0,000 0,13201475 0,14270444 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,13201475 0,14264132 ! neuromuscular process GO:0050905 107 54 0,000 0,13201475 0,14257826 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,13201475 0,14251526 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,13201475 0,14245231 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,13201475 0,14238942 ! regulation of cell shape GO:0008360 142 54 0,000 0,13201475 0,14232658 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,13201475 0,1422638 ! RNA catabolic process GO:0006401 103 55 0,000 0,13428926 0,14465109 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,13428926 0,14458734 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,13428926 0,14452364 ! cell recognition GO:0008037 98 55 0,000 0,13428926 0,14446001 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,13428926 0,14439642 ! cell maturation GO:0048469 107 55 0,000 0,13428926 0,1443329 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,13428926 0,14426943 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,13655789 0,14664216 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,13655789 0,14657773 ! glucose catabolic process GO:0006007 88 56 0,000 0,13655789 0,14651336 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,13655789 0,14644904 ! RNA elongation GO:0006354 90 56 0,000 0,13655789 0,14638478 ! chloride transport GO:0006821 102 57 0,000 0,13882063 0,14874508 ! muscle fiber development GO:0048747 131 57 0,000 0,13882063 0,14867987 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,13882063 0,14861472 ! regulation of actin filament length GO:0030832 118 58 0,000 0,1410775 0,15096467 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,1410775 0,15089857 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,1410775 0,15083253 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,1410775 0,15076655 ! gastrulation GO:0007369 122 58 0,000 0,1410775 0,15070063 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,1410775 0,15063476 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,14557371 0,15536766 ! DNA catabolic process GO:0006308 94 60 0,000 0,14557371 0,15529981 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,14557371 0,15523203 ! adult behavior GO:0030534 104 60 0,000 0,14557371 0,1551643 ! kidney development GO:0001822 133 60 0,000 0,14557371 0,15509663 ! positive regulation of secretion GO:0051047 110 61 0,000 0,14781307 0,15741384 ! regulation of cellular component size GO:0032535 125 61 0,000 0,14781307 0,15734525 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,14781307 0,15727672 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,14781307 0,15720825 ! regulation of heart contraction GO:0008016 123 61 0,000 0,14781307 0,15713984 ! camera-type eye development GO:0043010 126 61 0,000 0,14781307 0,15707148 ! proton transport GO:0015992 117 61 0,000 0,14781307 0,15700319 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,14781307 0,15693496 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,15004663 0,15923715 ! tRNA processing GO:0008033 102 62 0,000 0,15004663 0,15916801 ! mesoderm development GO:0007498 128 63 0,000 0,1522744 0,1614611 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,1522744 0,16139105 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,1522744 0,16132106 ! hydrogen transport GO:0006818 121 64 0,000 0,15449639 0,16360411 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,15449639 0,16353323 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,15449639 0,1634624 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,15671262 0,16573547 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,15671262 0,16566376 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,15671262 0,1655921 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,15671262 0,16552051 ! ear development GO:0043583 114 66 0,000 0,15892311 0,16778269 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,15892311 0,16771022 ! gonad development GO:0008406 115 66 0,000 0,15892311 0,1676378 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,16112786 0,1698901 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,16112786 0,16981681 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,16112786 0,16974358 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,16112786 0,16967041 ! secondary metabolic process GO:0019748 125 67 0,000 0,16112786 0,16959731 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,16332689 0,1718379 ! hexose catabolic process GO:0019320 113 68 0,000 0,16332689 0,17176392 ! extracellular matrix organization GO:0030198 146 68 0,000 0,16332689 0,17169001 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,16332689 0,17161617 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,16332689 0,17154239 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,16332689 0,17146867 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,16332689 0,17139501 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,16552022 0,17362211 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,16552022 0,1735476 ! urogenital system development GO:0001655 149 69 0,000 0,16552022 0,17347314 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,16552022 0,17339876 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,16552022 0,17332443 ! developmental maturation GO:0021700 128 69 0,000 0,16552022 0,17325017 ! single fertilization GO:0007338 83 69 0,000 0,16552022 0,17317597 ! cell redox homeostasis GO:0045454 114 70 0,000 0,16770786 0,17538969 ! germ cell development GO:0007281 133 70 0,000 0,16770786 0,17531464 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,16988983 0,17751962 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,16988983 0,17744372 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,16988983 0,17736789 ! appendage morphogenesis GO:0035107 150 72 0,000 0,17206614 0,17956326 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,17206614 0,17948659 ! actin filament organization GO:0007015 167 72 0,000 0,17206614 0,17940998 ! B cell activation GO:0042113 179 72 0,000 0,17206614 0,17933344 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,17206614 0,17925697 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,17206614 0,17918056 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,17206614 0,17910421 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,17206614 0,17902793 ! appendage development GO:0048736 151 73 0,000 0,17423681 0,18120925 GO:0060173|limb development, ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,17423681 0,18113214 ! regulation of immune effector process GO:0002697 156 73 0,000 0,17423681 0,18105509 ! amino acid transport GO:0006865 148 74 0,000 0,17640184 0,18322692 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,17640184 0,18314905 ! transition metal ion transport GO:0000041 143 75 0,000 0,17856126 0,18531231 ! reproductive structure development GO:0048608 131 75 0,000 0,17856126 0,18523362 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,17856126 0,18515499 ! eye development GO:0001654 155 75 0,000 0,17856126 0,18507644 ! axon guidance GO:0007411 162 75 0,000 0,17856126 0,18499795 ! rhythmic process GO:0048511 142 75 0,000 0,17856126 0,18491953 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,18071508 0,18707074 ! learning or memory GO:0007611 161 76 0,000 0,18071508 0,18699151 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,18071508 0,18691234 ! regulation of blood pressure GO:0008217 134 76 0,000 0,18071508 0,18683324 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,18071508 0,18675421 ! amine catabolic process GO:0009310 136 77 0,000 0,18286332 0,18889433 ! neurotransmitter transport GO:0006836 142 77 0,000 0,18286332 0,18881449 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,18286332 0,18873472 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,18286332 0,18865502 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,18286332 0,18857538 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,18500597 0,19070447 ! fertilization GO:0009566 99 78 0,000 0,18500597 0,19062404 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,18714308 0,19274475 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,18714308 0,19266352 ! steroid biosynthetic process GO:0006694 146 79 0,000 0,18714308 0,19258237 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,18714308 0,19250128 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,18714308 0,19242026 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,18927463 0,19453005 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,18927463 0,19444825 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,18927463 0,19436651 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,18927463 0,19428484 ! meiosis GO:0007126 143 81 0,000 0,19140066 0,19638464 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 0,000 0,19140066 0,19630219 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,19140066 0,19621981 ! protein import into nucleus GO:0006606 174 82 0,000 0,19352117 0,1983105 ! meiotic cell cycle GO:0051321 144 82 0,000 0,19352117 0,19822735 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,19563619 0,20030981 ! exocytosis GO:0006887 153 83 0,000 0,19563619 0,20022589 ! response to drug GO:0042493 149 83 0,000 0,19563619 0,20014204 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,19563619 0,20005827 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,19563619 0,19997456 ! nuclear import GO:0051170 177 83 0,000 0,19563619 0,19989093 ! inorganic anion transport GO:0015698 156 83 0,000 0,19563619 0,19980736 ! response to metal ion GO:0010038 158 84 0,000 0,19774571 0,20187746 ! T cell activation GO:0042110 189 84 0,000 0,19774571 0,20179314 ! response to nutrient GO:0007584 135 84 0,000 0,19774571 0,20170888 ! digestion GO:0007586 130 84 0,000 0,19774571 0,2016247 ! regulation of ligase activity GO:0051340 147 84 0,000 0,19774571 0,20154058 ! negative regulation of transport GO:0051051 164 85 0,000 0,19984976 0,20360007 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,19984976 0,2035152 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,19984976 0,2034304 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,19984976 0,20334568 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,20194835 0,20539543 ! regulation of lyase activity GO:0051339 169 86 0,000 0,20194835 0,20530996 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,2040415 0,20735166 ! alcohol catabolic process GO:0046164 142 87 0,000 0,2040415 0,20726544 ! nucleosome assembly GO:0006334 126 87 0,000 0,2040415 0,2071793 ! cellular respiration GO:0045333 143 88 0,000 0,20612922 0,20921216 ! amine biosynthetic process GO:0009309 146 88 0,000 0,20612922 0,20912528 ! sensory perception of smell GO:0007608 117 88 0,000 0,20612922 0,20903847 ! chromatin assembly GO:0031497 128 88 0,000 0,20612922 0,20895173 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,20612922 0,20886507 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,20821151 0,21088753 ! tube morphogenesis GO:0035239 194 89 0,000 0,20821151 0,21080014 ! cellular defense response GO:0006968 123 89 0,000 0,20821151 0,21071281 ! protein localization in nucleus GO:0034504 192 89 0,000 0,20821151 0,21062556 ! regulation of neurological system process GO:0031644 175 89 0,000 0,20821151 0,21053838 ! response to inorganic substance GO:0010035 173 90 0,000 0,21028841 0,21255051 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,21028841 0,21246261 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,21028841 0,21237478 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,21235992 0,21437821 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,21235992 0,21428966 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,21442605 0,21628523 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,21648682 0,21827375 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,21648682 0,2181837 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,21648682 0,21809373 ! vitamin metabolic process GO:0006766 153 93 0,000 0,21648682 0,21800383 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,21854224 0,21998298 ! female pregnancy GO:0007565 166 94 0,000 0,21854224 0,21989237 ! sterol metabolic process GO:0016125 166 94 0,000 0,21854224 0,21980185 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,21854224 0,21971139 ! regulation of defense response GO:0031347 171 95 0,000 0,22059232 0,22168122 ! nucleosome organization GO:0034728 143 95 0,000 0,22059232 0,22159007 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,22059232 0,22149899 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,22059232 0,22140799 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,22059232 0,22131706 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,22059232 0,22122621 ! sex differentiation GO:0007548 171 96 0,000 0,22263709 0,22318523 ! regulation of T cell activation GO:0050863 175 96 0,000 0,22263709 0,22309369 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,22467655 0,22504502 ! transcription initiation GO:0006352 171 97 0,000 0,22467655 0,22495279 ! forebrain development GO:0030900 210 98 0,000 0,22671071 0,22689647 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,22671071 0,22680355 ! hormone metabolic process GO:0042445 171 100 0,000 0,23076322 0,23076322