pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1155-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 5,000 4,617E-12 1,128E-08 ! phospholipid dephosphorylation GO:0046839 12 5 3,000 2,399E-09 2,93E-06 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 7,17E-09 5,839E-06 ! negative regulation of focal adhesion formation GO:0051895 21 7 3,000 1,667E-08 1,018E-05 ! regulation of focal adhesion formation GO:0051893 23 8 3,000 3,321E-08 1,623E-05 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 4,000 4,253E-08 1,732E-05 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 3,000 9,89E-08 3,452E-05 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 3,000 1,548E-07 4,729E-05 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of protein kinase cascade GO:0010741 72 30 4,000 2,878E-07 7,811E-05 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 5,000 3,03E-07 7,402E-05 ! cellular response to insulin stimulus GO:0032869 85 38 4,000 9,831E-07 2,183E-04 ! endothelial cell migration GO:0043542 31 17 3,000 1,092E-06 2,224E-04 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 3,000 1,092E-06 2,053E-04 ! cardiac muscle tissue development GO:0048738 34 17 3,000 1,092E-06 1,906E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 3,000 1,399E-06 2,279E-04 ! inositol metabolic process GO:0006020 33 19 3,000 1,766E-06 2,696E-04 ! myoblast cell fate commitment GO:0048625 18 6 2,000 2,053E-06 2,95E-04 ! nuclear migration GO:0007097 13 6 2,000 2,053E-06 2,786E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 2,053E-06 2,64E-04 GO:0031272|regulation of pseudopodium assembly, ! response to insulin stimulus GO:0032868 98 47 4,000 2,903E-06 3,546E-04 ! cellular response to hormone stimulus GO:0032870 182 85 5,000 3,274E-06 3,809E-04 ! regulation of cell-matrix adhesion GO:0001952 81 23 3,000 3,975E-06 4,414E-04 GO:0010810|regulation of cell-substrate adhesion, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 2,000 5,708E-06 6,063E-04 ! regulation of lipid kinase activity GO:0043550 17 8 2,000 5,708E-06 5,81E-04 ! positive regulation of insulin secretion GO:0032024 17 8 2,000 5,708E-06 5,578E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 5,708E-06 5,363E-04 ! insulin receptor signaling pathway GO:0008286 66 27 3,000 7,763E-06 7,024E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 8,532E-06 7,444E-04 ! macrophage differentiation GO:0030225 15 9 2,000 8,532E-06 7,188E-04 ! lipid modification GO:0030258 112 60 4,000 9,836E-06 8,01E-04 ! negative regulation of protein complex assembly GO:0031333 68 30 3,000 1,199E-05 9,448E-04 ! regulation of protein complex assembly GO:0043254 132 63 4,000 1,251E-05 9,554E-04 ! protein amino acid autophosphorylation GO:0046777 157 64 4,000 1,352E-05 1,001E-03 ! response to peptide hormone stimulus GO:0043434 129 64 4,000 1,352E-05 9,717E-04 ! positive regulation of catabolic process GO:0009896 72 32 3,000 1,562E-05 1,09E-03 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 2,000 1,664E-05 1,129E-03 ! positive regulation of peptide secretion GO:0002793 24 11 2,000 1,664E-05 1,099E-03 ! regulation of embryonic development GO:0045995 35 11 2,000 1,664E-05 1,07E-03 ! nucleus localization GO:0051647 22 11 2,000 1,664E-05 1,043E-03 ! positive regulation of cellular catabolic process GO:0031331 34 12 2,000 2,211E-05 1,351E-03 ! regulation of cell projection assembly GO:0060491 33 12 2,000 2,211E-05 1,318E-03 ! regulation of hormone metabolic process GO:0032350 28 12 2,000 2,211E-05 1,286E-03 ! regulation of MAPKKK cascade GO:0043408 157 72 4,000 2,407E-05 1,368E-03 ! negative regulation of cell adhesion GO:0007162 94 37 3,000 2,816E-05 1,563E-03 ! regulation of monooxygenase activity GO:0032768 35 13 2,000 2,865E-05 1,555E-03 ! regulation of protein stability GO:0031647 77 38 3,000 3,135E-05 1,665E-03 ! phosphoinositide metabolic process GO:0030384 146 77 4,000 3,335E-05 1,734E-03 ! carbohydrate homeostasis GO:0033500 59 39 3,000 3,481E-05 1,772E-03 GO:0042593|glucose homeostasis, ! lipid localization GO:0010876 32 14 2,000 3,634E-05 1,812E-03 GO:0019915|lipid storage, ! protein oligomerization GO:0051259 149 79 4,000 3,776E-05 1,845E-03 ! mesenchymal cell development GO:0014031 94 41 3,000 4,254E-05 2,038E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 4,526E-05 2,126E-03 ! polyol metabolic process GO:0019751 77 45 3,000 6,168E-05 2,843E-03 ! filopodium assembly GO:0046847 42 17 2,000 6,717E-05 3,039E-03 ! myoblast differentiation GO:0045445 50 17 2,000 6,717E-05 2,984E-03 ! negative regulation of cell migration GO:0030336 122 46 3,000 6,73E-05 2,936E-03 ! regulation of JNK cascade GO:0046328 104 47 3,000 7,329E-05 3,141E-03 ! regulation of cell adhesion GO:0030155 241 92 4,000 7,841E-05 3,303E-03 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 3,000 7,966E-05 3,299E-03 ! positive regulation of proteolysis GO:0045862 36 18 2,000 8,033E-05 3,271E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 2,000 8,033E-05 3,217E-03 ! detection of bacterium GO:0016045 22 18 2,000 8,033E-05 3,165E-03 ! microspike assembly GO:0030035 46 18 2,000 8,033E-05 3,115E-03 ! positive regulation of hormone secretion GO:0046887 35 19 2,000 9,506E-05 3,629E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 1,114E-04 4,189E-03 ! regulation of carbohydrate metabolic process GO:0006109 37 20 2,000 1,114E-04 4,125E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! pancreas development GO:0031016 40 20 2,000 1,114E-04 4,064E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 1,114E-04 4,004E-03 ! skeletal muscle tissue development GO:0007519 223 100 4,000 1,165E-04 4,123E-03 GO:0060538|skeletal muscle organ development, ! negative regulation of cell motion GO:0051271 142 55 3,000 1,361E-04 4,749E-03 ! positive regulation of protein catabolic process GO:0045732 44 22 2,000 1,495E-04 5,144E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 1,495E-04 5,073E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 1,495E-04 5,003E-03 ! regulation of cellular catabolic process GO:0031329 55 24 2,000 1,951E-04 6,442E-03 ! sex determination GO:0007530 48 24 2,000 1,951E-04 6,356E-03 ! detection of biotic stimulus GO:0009595 34 24 2,000 1,951E-04 6,273E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 1,951E-04 6,191E-03 ! negative regulation of response to stimulus GO:0048585 106 61 3,000 2,037E-04 6,38E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 2,2E-04 6,804E-03 ! anagen GO:0042640 7 5 1,000 2,2E-04 6,719E-03 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 1,000 2,2E-04 6,636E-03 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! microvillus organization GO:0032528 8 5 1,000 2,2E-04 6,555E-03 GO:0030033|microvillus assembly, ! response to food GO:0032094 6 5 1,000 2,2E-04 6,476E-03 ! regulation of glycogen metabolic process GO:0070873 10 5 1,000 2,2E-04 6,399E-03 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 2,2E-04 6,323E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 1,000 2,2E-04 6,25E-03 ! positive regulation of vasoconstriction GO:0045907 10 5 1,000 2,2E-04 6,178E-03 ! negative regulation of T cell mediated immunity GO:0002710 15 5 1,000 2,2E-04 6,108E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! enteric nervous system development GO:0048484 8 5 1,000 2,2E-04 6,039E-03 ! regulation of sensory perception GO:0051931 8 5 1,000 2,2E-04 5,972E-03 GO:0051930|regulation of sensory perception of pain, ! protein insertion into membrane GO:0051205 17 5 1,000 2,2E-04 5,906E-03 ! protein import into nucleus, translocation GO:0000060 51 25 2,000 2,21E-04 5,868E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 2,21E-04 5,805E-03 ! regulation of insulin secretion GO:0050796 42 25 2,000 2,21E-04 5,743E-03 ! interaction with host GO:0051701 66 25 2,000 2,21E-04 5,683E-03 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 2,762E-04 7,029E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 2,791E-04 7,029E-03 ! regulation of cellular response to stress GO:0080135 142 68 3,000 3,098E-04 7,723E-03 ! cell projection assembly GO:0030031 138 68 3,000 3,098E-04 7,645E-03 ! fat cell differentiation GO:0045444 57 28 2,000 3,115E-04 7,61E-03 ! urogenital system development GO:0001655 149 69 3,000 3,277E-04 7,926E-03 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 1,000 3,29E-04 7,88E-03 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! vascular smooth muscle contraction GO:0014829 13 6 1,000 3,29E-04 7,803E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 3,29E-04 7,728E-03 ! hair follicle maturation GO:0048820 8 6 1,000 3,29E-04 7,654E-03 ! cellular anion homeostasis GO:0030002 11 6 1,000 3,29E-04 7,582E-03 GO:0055081|anion homeostasis, ! regulation of peptide secretion GO:0002791 52 29 2,000 3,462E-04 7,905E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 2,000 3,462E-04 7,832E-03 ! cytokinesis during cell cycle GO:0033205 14 7 1,000 4,592E-04 0,01029093 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 4,592E-04 0,01019738 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 4,592E-04 0,01010551 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 1,000 4,592E-04 0,01001528 ! vesicle fusion GO:0006906 20 7 1,000 4,592E-04 9,927E-03 ! male sex determination GO:0030238 15 7 1,000 4,592E-04 9,84E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 1,000 4,592E-04 9,754E-03 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 4,592E-04 9,67E-03 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 1,000 4,592E-04 9,587E-03 ! positive regulation of microtubule polymerization GO:0031116 15 7 1,000 4,592E-04 9,506E-03 ! metanephros development GO:0001656 81 32 2,000 4,651E-04 9,548E-03 ! BMP signaling pathway GO:0030509 71 32 2,000 4,651E-04 9,469E-03 ! regulation of catabolic process GO:0009894 173 77 3,000 4,981E-04 0,01005691 ! steroid biosynthetic process GO:0006694 146 79 3,000 5,49E-04 0,01099356 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 5,573E-04 0,01106808 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 3,000 5,758E-04 0,01134392 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 1,000 6,103E-04 0,01192774 ! ER overload response GO:0006983 13 8 1,000 6,103E-04 0,01183308 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 6,103E-04 0,0117399 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 6,103E-04 0,01164818 ! gas homeostasis GO:0033483 14 8 1,000 6,103E-04 0,01155789 ! regulation of respiratory burst GO:0060263 12 8 1,000 6,103E-04 0,01146898 ! lymph node development GO:0048535 11 8 1,000 6,103E-04 0,01138143 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 1,000 6,103E-04 0,01129521 ! regulation of microtubule polymerization GO:0031113 17 8 1,000 6,103E-04 0,01121028 ! regulation of peptidase activity GO:0052547 150 82 3,000 6,321E-04 0,0115243 ! regulation of proteolysis GO:0030162 77 36 2,000 6,603E-04 0,01194927 ! tissue remodeling GO:0048771 78 37 2,000 7,161E-04 0,01286337 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 7,161E-04 0,01276948 ! glycogen metabolic process GO:0005977 63 38 2,000 7,748E-04 0,01371597 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 7,822E-04 0,01374822 ! regulation of epithelial cell differentiation GO:0030856 18 9 1,000 7,822E-04 0,01365002 ! regulation of glycolysis GO:0006110 20 9 1,000 7,822E-04 0,01355321 ! negative regulation of endocytosis GO:0045806 12 9 1,000 7,822E-04 0,01345777 ! glycine catabolic process GO:0006546 15 9 1,000 7,822E-04 0,01336366 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 1,000 7,822E-04 0,01327085 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 1,000 7,822E-04 0,01317933 GO:0002820|negative regulation of adaptive immune response, ! glucan metabolic process GO:0044042 64 39 2,000 8,365E-04 0,01399624 GO:0006073|cellular glucan metabolic process, ! glycerol ether metabolic process GO:0006662 57 40 2,000 9,011E-04 0,01497621 ! ossification GO:0001503 205 91 3,000 9,346E-04 0,01542783 ! regulation of hormone secretion GO:0046883 69 41 2,000 9,689E-04 0,01588658 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 9,689E-04 0,01578067 ! bone development GO:0060348 206 92 3,000 9,736E-04 0,01575099 ! regulation of developmental growth GO:0048638 16 10 1,000 9,748E-04 0,01566668 ! SMAD protein nuclear translocation GO:0007184 21 10 1,000 9,748E-04 0,01556428 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 1,000 9,748E-04 0,01546321 ! glucan biosynthetic process GO:0009250 14 10 1,000 9,748E-04 0,01536345 GO:0005978|glycogen biosynthetic process, ! protein heterooligomerization GO:0051291 17 10 1,000 9,748E-04 0,01526497 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 1,000 9,748E-04 0,01516774 ! regulation of fat cell differentiation GO:0045598 18 10 1,000 9,748E-04 0,01507174 ! induction of an organ GO:0001759 17 10 1,000 9,748E-04 0,01497695 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 9,748E-04 0,01488334 ! midbrain development GO:0030901 14 10 1,000 9,748E-04 0,0147909 ! serine family amino acid catabolic process GO:0009071 18 10 1,000 9,748E-04 0,0146996 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 9,748E-04 0,01460942 GO:0043470|regulation of carbohydrate catabolic process, ! negative regulation of immune effector process GO:0002698 23 10 1,000 9,748E-04 0,01452033 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 1,014E-03 0,01500745 ! organic ether metabolic process GO:0018904 59 42 2,000 1,04E-03 0,01530351 ! regulation of intracellular protein transport GO:0033157 86 42 2,000 1,04E-03 0,01521187 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 2,000 1,114E-03 0,01619929 ! thyroid gland development GO:0030878 26 11 1,000 1,188E-03 0,01716855 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 1,188E-03 0,01706756 ! negative regulation of ossification GO:0030279 27 11 1,000 1,188E-03 0,01696775 ! vasoconstriction GO:0042310 20 11 1,000 1,188E-03 0,0168691 ! neuroblast proliferation GO:0007405 25 11 1,000 1,188E-03 0,01677159 ! negative regulation of glucose import GO:0046325 18 11 1,000 1,188E-03 0,0166752 GO:0010829|negative regulation of glucose transport, ! energy reserve metabolic process GO:0006112 76 44 2,000 1,191E-03 0,01663161 ! leukocyte differentiation GO:0002521 232 98 3,000 1,231E-03 0,01709172 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 1,231E-03 0,01699515 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 1,356E-03 0,0186124 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 1,356E-03 0,01850842 ! cell growth GO:0016049 90 46 2,000 1,356E-03 0,0184056 ! positive regulation of protein transport GO:0051222 80 46 2,000 1,356E-03 0,01830391 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 1,000 1,421E-03 0,0190713 ! virus-host interaction GO:0019048 30 12 1,000 1,421E-03 0,01896709 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 1,421E-03 0,018864 ! entry into host cell GO:0030260 34 12 1,000 1,421E-03 0,01876204 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 1,421E-03 0,01866117 ! autonomic nervous system development GO:0048483 24 12 1,000 1,421E-03 0,01856137 ! peptidyl-lysine modification GO:0018205 21 12 1,000 1,421E-03 0,01846264 ! T cell homeostasis GO:0043029 28 12 1,000 1,421E-03 0,01836496 ! developmental induction GO:0031128 22 12 1,000 1,421E-03 0,0182683 GO:0045168|cell-cell signaling involved in cell fate specification, ! localization within membrane GO:0051668 26 12 1,000 1,421E-03 0,01817265 ! positive regulation of cell cycle GO:0045787 96 48 2,000 1,535E-03 0,01952513 ! protein homooligomerization GO:0051260 84 49 2,000 1,629E-03 0,02061939 ! organelle fusion GO:0048284 36 13 1,000 1,674E-03 0,02107906 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 1,674E-03 0,02097096 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 1,674E-03 0,02086397 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! nucleoside triphosphate catabolic process GO:0009143 22 13 1,000 1,674E-03 0,02075806 ! gland morphogenesis GO:0022612 31 13 1,000 1,674E-03 0,02065322 ! regulation of ossification GO:0030278 123 50 2,000 1,727E-03 0,02120081 ! regulation of cell projection organization GO:0031344 135 51 2,000 1,829E-03 0,02233598 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 1,000 1,947E-03 0,02366219 ! regulation of RNA stability GO:0043487 33 14 1,000 1,947E-03 0,02354505 ! positive regulation of protein polymerization GO:0032273 27 14 1,000 1,947E-03 0,02342906 ! positive regulation of growth GO:0045927 96 53 2,000 2,043E-03 0,02446358 ! chromatin remodeling GO:0006338 122 53 2,000 2,043E-03 0,02434425 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 2,239E-03 0,02655726 ! negative regulation of bone remodeling GO:0046851 34 15 1,000 2,239E-03 0,02642897 ! sulfate transport GO:0008272 27 15 1,000 2,239E-03 0,02630191 ! regulation of vasodilation GO:0042312 27 15 1,000 2,239E-03 0,02617606 ! regulation of T cell mediated immunity GO:0002709 36 15 1,000 2,239E-03 0,02605141 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 2,239E-03 0,02592795 ! lymphocyte homeostasis GO:0002260 33 15 1,000 2,239E-03 0,02580564 ! regulation of protein polymerization GO:0032271 117 55 2,000 2,272E-03 0,02605895 ! response to UV GO:0009411 120 55 2,000 2,272E-03 0,02593718 ! skeletal muscle fiber development GO:0048741 130 56 2,000 2,392E-03 0,02718395 ! regulation of protein catabolic process GO:0042176 126 56 2,000 2,392E-03 0,02705809 ! regulation of bone remodeling GO:0046850 143 57 2,000 2,517E-03 0,02833185 ! muscle fiber development GO:0048747 131 57 2,000 2,517E-03 0,02820188 ! regulation of intracellular transport GO:0032386 108 57 2,000 2,517E-03 0,02807311 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 2,551E-03 0,02833166 ! bone remodeling GO:0046849 28 16 1,000 2,551E-03 0,02820346 ! startle response GO:0001964 28 16 1,000 2,551E-03 0,02807642 ! negative regulation of immune response GO:0050777 38 16 1,000 2,551E-03 0,02795052 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 2,551E-03 0,02782574 ! negative regulation of inflammatory response GO:0050728 24 16 1,000 2,551E-03 0,02770207 ! negative regulation of tissue remodeling GO:0034104 37 16 1,000 2,551E-03 0,02757949 ! positive regulation of cell migration GO:0030335 137 58 2,000 2,645E-03 0,02846276 ! cellular polysaccharide metabolic process GO:0044264 93 58 2,000 2,645E-03 0,02833792 ! regulation of tissue remodeling GO:0034103 146 58 2,000 2,645E-03 0,02821417 ! establishment of organelle localization GO:0051656 122 59 2,000 2,777E-03 0,02949458 ! signal complex assembly GO:0007172 47 17 1,000 2,883E-03 0,03048548 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 1,000 2,883E-03 0,03035408 ! regulation of survival gene product expression GO:0045884 38 17 1,000 2,883E-03 0,0302238 ! induction of apoptosis via death domain receptors GO:0008625 23 17 1,000 2,883E-03 0,03009464 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 1,000 2,883E-03 0,02996658 ! kidney development GO:0001822 133 60 2,000 2,913E-03 0,03015352 ! positive regulation of secretion GO:0051047 110 61 2,000 3,053E-03 0,03147077 ! viral reproductive process GO:0022415 132 62 2,000 3,197E-03 0,0328188 ! positive regulation of protein complex assembly GO:0031334 34 18 1,000 3,233E-03 0,03304554 ! positive regulation of anti-apoptosis GO:0045768 47 18 1,000 3,233E-03 0,03290785 ! glycine metabolic process GO:0006544 30 18 1,000 3,233E-03 0,0327713 ! neural crest cell migration GO:0001755 41 18 1,000 3,233E-03 0,03263588 ! mesoderm development GO:0007498 128 63 2,000 3,346E-03 0,03363467 ! negative regulation of defense response GO:0031348 27 19 1,000 3,602E-03 0,03606445 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 3,602E-03 0,03591725 ! neuron maturation GO:0042551 46 19 1,000 3,602E-03 0,03577124 ! positive regulation of cell motion GO:0051272 157 65 2,000 3,655E-03 0,03614752 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 3,816E-03 0,03758657 ! activation of MAPK activity GO:0000187 124 67 2,000 3,981E-03 0,03905583 ! myeloid cell differentiation GO:0030099 126 67 2,000 3,981E-03 0,0388996 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 3,99E-03 0,03883355 ! protein amino acid acetylation GO:0006473 41 20 1,000 3,99E-03 0,03867945 ! apoptotic mitochondrial changes GO:0008637 42 20 1,000 3,99E-03 0,03852656 ! regulation of fatty acid metabolic process GO:0019217 45 20 1,000 3,99E-03 0,03837489 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 1,000 3,99E-03 0,0382244 ! regulation of glucose import GO:0046324 30 20 1,000 3,99E-03 0,03807508 GO:0010827|regulation of glucose transport, ! detection of external stimulus GO:0009581 102 68 2,000 4,15E-03 0,03945062 ! viral reproduction GO:0016032 142 68 2,000 4,15E-03 0,03929771 ! negative regulation of cell size GO:0045792 144 69 2,000 4,324E-03 0,04078486 ! negative regulation of protein kinase activity GO:0006469 144 69 2,000 4,324E-03 0,040628 ! lung development GO:0030324 165 69 2,000 4,324E-03 0,04047233 ! homeostasis of number of cells GO:0048872 131 69 2,000 4,324E-03 0,04031786 ! developmental maturation GO:0021700 128 69 2,000 4,324E-03 0,04016456 ! regulation of cell killing GO:0031341 46 21 1,000 4,396E-03 0,04068153 ! lipid phosphorylation GO:0046834 43 21 1,000 4,396E-03 0,04052802 ! smooth muscle contraction GO:0006939 48 21 1,000 4,396E-03 0,04037565 ! regulation of vasoconstriction GO:0019229 40 21 1,000 4,396E-03 0,04022443 ! positive regulation of osteoblast differentiation GO:0045669 52 21 1,000 4,396E-03 0,04007434 ! negative regulation of kinase activity GO:0033673 145 70 2,000 4,502E-03 0,04088619 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 2,000 4,684E-03 0,04238595 ! inactivation of MAPK activity GO:0000188 45 22 1,000 4,821E-03 0,04345901 ! ureteric bud development GO:0001657 50 22 1,000 4,821E-03 0,04329923 ! G1 phase GO:0051318 44 22 1,000 4,821E-03 0,04314063 ! activation of JUN kinase activity GO:0007257 47 22 1,000 4,821E-03 0,04298318 ! gut development GO:0048565 44 22 1,000 4,821E-03 0,04282688 ! respiratory tube development GO:0030323 171 72 2,000 4,871E-03 0,04311889 ! regulation of caspase activity GO:0043281 136 74 2,000 5,259E-03 0,04637793 ! negative regulation of transferase activity GO:0051348 155 74 2,000 5,259E-03 0,0462111 ! respiratory system development GO:0060541 175 74 2,000 5,259E-03 0,04604547 ! organelle localization GO:0051640 155 74 2,000 5,259E-03 0,04588102 ! positive regulation of DNA replication GO:0045740 44 23 1,000 5,264E-03 0,04576222 ! regulation of anti-apoptosis GO:0045767 62 23 1,000 5,264E-03 0,04559994 ! regulation of DNA recombination GO:0000018 51 23 1,000 5,264E-03 0,04543881 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 5,264E-03 0,04527881 ! regulation of bone mineralization GO:0030500 54 23 1,000 5,264E-03 0,04511994 ! protein amino acid O-linked glycosylation GO:0006493 45 24 1,000 5,724E-03 0,04889812 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 5,724E-03 0,04872774 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 5,724E-03 0,04855855 ! positive regulation of cytoskeleton organization GO:0051495 52 24 1,000 5,724E-03 0,04839052 ! barbed-end actin filament capping GO:0051016 58 24 1,000 5,724E-03 0,04822366 GO:0051693|actin filament capping, ! negative regulation of phosphorylation GO:0042326 52 24 1,000 5,724E-03 0,04805794 ! membrane depolarization GO:0051899 45 24 1,000 5,724E-03 0,04789336 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 5,724E-03 0,0477299 ! regulation of endopeptidase activity GO:0052548 141 77 2,000 5,873E-03 0,04880331 ! vasculogenesis GO:0001570 49 25 1,000 6,203E-03 0,05136947 ! regulation of biomineral formation GO:0070167 56 25 1,000 6,203E-03 0,05119592 ! leukocyte homeostasis GO:0001776 50 25 1,000 6,203E-03 0,05102355 ! protein tetramerization GO:0051262 57 25 1,000 6,203E-03 0,05085233 ! initiation of viral infection GO:0019059 60 26 1,000 6,699E-03 0,05473628 ! molting cycle process GO:0022404 52 26 1,000 6,699E-03 0,05455382 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 6,699E-03 0,05437258 ! regulation of smooth muscle contraction GO:0006940 48 26 1,000 6,699E-03 0,05419254 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 6,699E-03 0,05401369 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 6,699E-03 0,05383601 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 1,000 6,699E-03 0,0536595 ! osteoblast differentiation GO:0001649 63 26 1,000 6,699E-03 0,05348414 ! response to endoplasmic reticulum stress GO:0034976 46 26 1,000 6,699E-03 0,05330993 ! neural crest cell development GO:0014032 59 26 1,000 6,699E-03 0,05313684 GO:0014033|neural crest cell differentiation, ! regulation of blood coagulation GO:0030193 46 26 1,000 6,699E-03 0,05296488 ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 6,699E-03 0,05279402 ! positive regulation of JUN kinase activity GO:0043507 59 26 1,000 6,699E-03 0,05262427 ! muscle cell differentiation GO:0042692 178 81 2,000 6,757E-03 0,05290775 ! response to hypoxia GO:0001666 178 81 2,000 6,757E-03 0,05273871 ! protein import into nucleus GO:0006606 174 82 2,000 6,99E-03 0,05438035 ! embryonic pattern specification GO:0009880 49 27 1,000 7,213E-03 0,05593935 ! negative regulation of actin filament depolymerization GO:0030835 63 27 1,000 7,213E-03 0,05576233 ! negative regulation of actin filament polymerization GO:0030837 61 27 1,000 7,213E-03 0,05558642 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 1,000 7,213E-03 0,05541162 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 7,213E-03 0,05523792 ! response to oxygen levels GO:0070482 183 83 2,000 7,227E-03 0,05517231 ! nuclear import GO:0051170 177 83 2,000 7,227E-03 0,05500044 ! inorganic anion transport GO:0015698 156 83 2,000 7,227E-03 0,05482963 ! negative regulation of transport GO:0051051 164 85 2,000 7,716E-03 0,05835684 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 7,744E-03 0,05838831 ! protein amino acid acylation GO:0043543 59 28 1,000 7,744E-03 0,05820865 ! vesicle docking GO:0048278 55 28 1,000 7,744E-03 0,0580301 ! negative regulation of protein modification process GO:0031400 66 28 1,000 7,744E-03 0,05785264 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 7,744E-03 0,05767626 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 7,744E-03 0,05750095 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 7,744E-03 0,05732671 ! negative regulation of protein polymerization GO:0032272 63 28 1,000 7,744E-03 0,05715351 ! regulation of protein transport GO:0051223 165 87 2,000 8,223E-03 0,06051203 GO:0070201|regulation of establishment of protein localization, ! ER-nuclear signaling pathway GO:0006984 52 29 1,000 8,292E-03 0,06083026 ! respiratory gaseous exchange GO:0007585 61 29 1,000 8,292E-03 0,06064814 ! somitogenesis GO:0001756 52 29 1,000 8,292E-03 0,0604671 ! protein localization in nucleus GO:0034504 192 89 2,000 8,751E-03 0,06362421 ! regulation of actin filament depolymerization GO:0030834 67 30 1,000 8,857E-03 0,06420318 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 1,000 8,857E-03 0,06401323 ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 8,857E-03 0,0638244 ! regulation of coagulation GO:0050818 52 30 1,000 8,857E-03 0,06363668 ! gland development GO:0048732 220 91 2,000 9,297E-03 0,0666066 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 9,438E-03 0,06741924 ! response to heat GO:0009408 54 31 1,000 9,438E-03 0,06722268 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 1,000 0,01003634 0,07127555 ! spindle organization GO:0007051 50 32 1,000 0,01003634 0,07106895 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 0,01003634 0,07086355 ! mesoderm formation GO:0001707 73 32 1,000 0,01003634 0,07065933 ! hindbrain development GO:0030902 65 32 1,000 0,01003634 0,07045629 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,01003634 0,07025441 ! negative regulation of multicellular organismal process GO:0051241 174 95 2,000 0,01044886 0,07293302 ! negative regulation of response to external stimulus GO:0032102 50 33 1,000 0,01065096 0,07413187 ! cholesterol homeostasis GO:0042632 60 33 1,000 0,01065096 0,07392127 GO:0055092|sterol homeostasis, ! triglyceride metabolic process GO:0006641 46 33 1,000 0,01065096 0,07371186 ! regulation of DNA metabolic process GO:0051052 188 97 2,000 0,01105435 0,07628748 ! regulation of protein localization GO:0032880 188 97 2,000 0,01105435 0,07607258 ! cholesterol transport GO:0030301 62 34 1,000 0,01128181 0,07741985 ! formation of primary germ layer GO:0001704 76 34 1,000 0,01128181 0,07720299 ! cell fate specification GO:0001708 56 34 1,000 0,01128181 0,07698734 ! negative regulation of MAP kinase activity GO:0043407 78 34 1,000 0,01128181 0,07677289 ! serine family amino acid metabolic process GO:0009069 56 34 1,000 0,01128181 0,07655963 ! adult locomotory behavior GO:0008344 62 34 1,000 0,01128181 0,07634756 ! membrane docking GO:0022406 69 35 1,000 0,01192875 0,08050257 ! mesoderm morphogenesis GO:0048332 80 35 1,000 0,01192875 0,0802808 ! sterol transport GO:0015918 63 35 1,000 0,01192875 0,08006025 ! calcium-mediated signaling GO:0019722 67 35 1,000 0,01192875 0,0798409 ! placenta development GO:0001890 53 35 1,000 0,01192875 0,07962276 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 1,000 0,0125916 0,08381817 ! actomyosin structure organization GO:0031032 68 37 1,000 0,0132702 0,08809535 ! regulation of microtubule-based process GO:0032886 86 37 1,000 0,0132702 0,08785661 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 0,01396439 0,09220269 ! neutral lipid metabolic process GO:0006638 54 38 1,000 0,01396439 0,09195416 GO:0006639|acylglycerol metabolic process, ! regulation of lymphocyte mediated immunity GO:0002706 79 39 1,000 0,014674 0,09636718 ! nucleotide catabolic process GO:0009166 70 39 1,000 0,014674 0,09610882 ! mammary gland development GO:0030879 93 40 1,000 0,01539889 0,10058687 ! lipid homeostasis GO:0055088 75 40 1,000 0,01539889 0,10031864 ! embryonic epithelial tube formation GO:0001838 85 41 1,000 0,01613889 0,10485986 ! T cell differentiation GO:0030217 93 42 1,000 0,01689384 0,10947388 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,01689384 0,10918426 ! regulation of T cell differentiation GO:0045580 78 42 1,000 0,01689384 0,10889618 ! cytokinesis GO:0000910 84 42 1,000 0,01689384 0,10860961 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,01766359 0,11326023 GO:0090047|positive regulation of transcription regulator activity, ! regulation of tube size GO:0035150 76 43 1,000 0,01766359 0,11296374 GO:0050880|regulation of blood vessel size, ! glucose transport GO:0015758 66 43 1,000 0,01766359 0,11266879 ! hormone-mediated signaling GO:0009755 84 43 1,000 0,01766359 0,11237539 ! segmentation GO:0035282 78 43 1,000 0,01766359 0,1120835 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 1,000 0,01844798 0,11675755 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,01844798 0,11645585 ! hexose transport GO:0008645 68 44 1,000 0,01844798 0,11615571 GO:0015749|monosaccharide transport, ! regulation of epithelial cell proliferation GO:0050678 122 45 1,000 0,01924686 0,12087424 ! keratinocyte differentiation GO:0030216 81 45 1,000 0,01924686 0,1205643 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 1,000 0,01924686 0,12025596 ! developmental growth GO:0048589 88 45 1,000 0,01924686 0,11994918 ! regulation of actin filament polymerization GO:0030833 99 46 1,000 0,02006008 0,12469914 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,02006008 0,12438265 ! polysaccharide biosynthetic process GO:0000271 79 46 1,000 0,02006008 0,12406776 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,02172891 0,1340498 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,02172891 0,13371214 ! vascular process in circulatory system GO:0003018 85 48 1,000 0,02172891 0,13337618 ! male sex differentiation GO:0046661 93 48 1,000 0,02172891 0,13304191 ! regulation of inflammatory response GO:0050727 84 48 1,000 0,02172891 0,1327093 ! regulation of adaptive immune response GO:0002819 92 48 1,000 0,02172891 0,13237836 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 0,02258422 0,13724692 ! JNK cascade GO:0007254 106 49 1,000 0,02258422 0,13690635 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,02341164 0,14157087 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,02341164 0,14122131 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,02341164 0,14087347 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02341164 0,14052735 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,02341164 0,14018292 ! neuron fate determination GO:0048664 7 5 0,000 0,02341164 0,13984017 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02341164 0,1394991 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,02341164 0,13915968 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,02341164 0,13882192 ! polyol transport GO:0015791 12 5 0,000 0,02341164 0,13848579 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02341164 0,13815128 ! response to superoxide GO:0000303 10 5 0,000 0,02341164 0,13781839 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02341164 0,13748709 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,02341164 0,13715739 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,02341164 0,13682926 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02341164 0,1365027 ! female meiosis GO:0007143 10 5 0,000 0,02341164 0,13617769 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,02341164 0,13585423 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02341164 0,1355323 ! hypothalamus development GO:0021854 9 5 0,000 0,02341164 0,13521189 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,02341164 0,134893 ! cobalt ion transport GO:0006824 11 5 0,000 0,02341164 0,1345756 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,02341164 0,1342597 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,02341164 0,13394527 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02341164 0,13363231 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,02341164 0,13332082 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,02341164 0,13301077 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02341164 0,13270216 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02341164 0,13239498 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,02341164 0,13208922 ! transposition GO:0032196 9 5 0,000 0,02341164 0,13178486 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,02341164 0,13148191 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,02341164 0,13118035 ! negative chemotaxis GO:0050919 16 5 0,000 0,02341164 0,13088016 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,02341164 0,13058135 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02341164 0,1302839 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,02341164 0,1299878 ! behavioral response to pain GO:0048266 10 5 0,000 0,02341164 0,12969304 ! clathrin coat assembly GO:0048268 15 5 0,000 0,02341164 0,12939962 ! Notch receptor processing GO:0007220 11 5 0,000 0,02341164 0,12910752 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02341164 0,12881674 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,02341164 0,12852726 ! micturition GO:0060073 9 5 0,000 0,02341164 0,12823908 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02341164 0,12795219 ! copulation GO:0007620 9 5 0,000 0,02341164 0,12766659 ! glial cell fate commitment GO:0021781 14 5 0,000 0,02341164 0,12738225 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,02341164 0,12709918 ! bioluminescence GO:0008218 9 5 0,000 0,02341164 0,12681736 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02341164 0,12653679 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02341164 0,12625746 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02341164 0,12597936 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,02341164 0,12570248 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02341164 0,12542682 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,02341164 0,12515236 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02341164 0,12487911 ! grooming behavior GO:0007625 6 5 0,000 0,02341164 0,12460704 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,02341164 0,12433615 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02341164 0,12406644 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,02341164 0,1237979 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02341164 0,12353052 ! response to protozoan GO:0001562 13 5 0,000 0,02341164 0,12326429 ! lymph vessel development GO:0001945 10 5 0,000 0,02341164 0,12299921 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,02341164 0,12273526 ! endochondral ossification GO:0001958 17 5 0,000 0,02341164 0,12247244 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02341164 0,12221075 ! single strand break repair GO:0000012 8 5 0,000 0,02341164 0,12195017 ! parathyroid gland development GO:0060017 14 5 0,000 0,02341164 0,1216907 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02341164 0,12143234 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02341164 0,12117506 ! cytokine secretion GO:0050663 15 5 0,000 0,02341164 0,12091888 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,02341164 0,12066378 ! ceramide catabolic process GO:0046514 7 5 0,000 0,02341164 0,12040975 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,02341164 0,12015679 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,02341164 0,11990489 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02341164 0,11965404 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02341164 0,11940424 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02341164 0,11915548 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,02341164 0,11890776 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02341164 0,11866106 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,02341164 0,11841538 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02341164 0,11817072 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02341164 0,11792707 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,02341164 0,11768442 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02341164 0,11744277 ! valine metabolic process GO:0006573 12 5 0,000 0,02341164 0,11720211 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,02341164 0,11696243 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,02341164 0,11672374 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,02341164 0,11648601 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,02341164 0,11624925 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,02341164 0,11601345 ! polyol catabolic process GO:0046174 9 5 0,000 0,02341164 0,1157786 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,02341164 0,11554471 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,02341164 0,11531175 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,02341164 0,11507974 ! muscle cell migration GO:0014812 8 5 0,000 0,02341164 0,11484866 ! mitochondrial fission GO:0000266 8 5 0,000 0,02341164 0,1146185 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,02341164 0,11438926 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,02341164 0,11416094 ! mRNA transcription GO:0009299 10 5 0,000 0,02341164 0,11393353 ! nerve growth factor processing GO:0032455 9 5 0,000 0,02341164 0,11370702 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,02341164 0,11348141 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,02341164 0,11325669 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,02341164 0,11303287 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02341164 0,11280992 ! monocyte activation GO:0042117 10 5 0,000 0,02341164 0,11258786 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02341164 0,11236666 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02341164 0,11214633 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02341164 0,11192687 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02341164 0,11170826 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02341164 0,11149051 ! forebrain neuron development GO:0021884 13 5 0,000 0,02341164 0,1112736 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02341164 0,11105753 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,02341164 0,11084231 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02341164 0,11062791 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02341164 0,11041434 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,02341164 0,1102016 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,02341164 0,10998967 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,02341164 0,10977856 ! lipid glycosylation GO:0030259 7 5 0,000 0,02341164 0,10956826 ! nucleobase transport GO:0015851 6 5 0,000 0,02341164 0,10935876 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02341164 0,10915006 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,02341164 0,10894215 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,02341164 0,10873504 ! basic amino acid transport GO:0015802 12 5 0,000 0,02341164 0,10852871 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,02341164 0,10832316 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,02341164 0,10811839 ! actin nucleation GO:0045010 11 5 0,000 0,02341164 0,1079144 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02341164 0,10771117 ! depurination GO:0045007 5 5 0,000 0,02341164 0,1075087 ! depyrimidination GO:0045008 10 5 0,000 0,02341164 0,107307 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02341164 0,10710605 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02341164 0,10690585 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,02341164 0,1067064 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,02341164 0,10650769 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,02341164 0,10630972 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,02341164 0,10611249 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,02341164 0,10591598 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02341164 0,1057202 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02341164 0,10552515 ! activated T cell proliferation GO:0050798 16 5 0,000 0,02341164 0,10533081 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02341164 0,10513719 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,02341164 0,10494428 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02341164 0,10475207 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02341164 0,10456057 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,02341164 0,10436976 ! response to arsenic GO:0046685 11 5 0,000 0,02341164 0,10417965 ! mast cell degranulation GO:0043303 7 5 0,000 0,02341164 0,10399024 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,02341164 0,10380151 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,02341164 0,10361346 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,02341164 0,10342609 ! response to mercury ion GO:0046689 8 5 0,000 0,02341164 0,10323941 ! response to cadmium ion GO:0046686 7 5 0,000 0,02341164 0,10305339 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,02341164 0,10286804 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,02341164 0,10268336 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,02341164 0,10249934 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,02341164 0,10231598 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,02341164 0,10213327 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,02341164 0,10195121 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02341164 0,10176981 ! decidualization GO:0046697 11 5 0,000 0,02341164 0,10158904 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,02341164 0,10140892 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,02341164 0,10122943 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,02341164 0,10105058 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,02341164 0,10087236 ! embryonic cleavage GO:0040016 6 5 0,000 0,02341164 0,10069477 ! peroxisome fission GO:0016559 5 5 0,000 0,02341164 0,1005178 ! histone demethylation GO:0016577 13 5 0,000 0,02341164 0,10034146 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,02341164 0,10016573 ! mitotic recombination GO:0006312 9 5 0,000 0,02341164 0,09999061 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,02341164 0,09981611 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02341164 0,09964221 ! metaphase plate congression GO:0051310 7 5 0,000 0,02341164 0,09946892 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02341164 0,09929623 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02341164 0,09912414 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,02341164 0,09895265 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,02341164 0,09878175 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,02341164 0,09861143 ! muscle cell proliferation GO:0033002 12 5 0,000 0,02341164 0,0984417 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02341164 0,09827256 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,02341164 0,098104 ! B cell homeostasis GO:0001782 13 5 0,000 0,02341164 0,09793601 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,02341164 0,0977686 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02341164 0,09760176 ! metaphase GO:0051323 11 5 0,000 0,02341164 0,09743549 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,02341164 0,09726978 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,02341164 0,09710464 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02341164 0,09694005 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02341164 0,09677602 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,02341164 0,09661255 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,02341164 0,09644963 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02341164 0,09628726 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,02341164 0,09612543 ! response to redox state GO:0051775 6 5 0,000 0,02341164 0,09596415 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,02341164 0,0958034 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,02341164 0,09564319 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02341164 0,09548352 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,02341164 0,09532438 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,02341164 0,09516577 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02341164 0,09500769 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,02341164 0,09485013 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02341164 0,0946931 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,02341164 0,09453658 ! striatum development GO:0021756 14 5 0,000 0,02341164 0,09438058 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,02341164 0,09422509 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02341164 0,09407012 ! glial cell migration GO:0008347 10 5 0,000 0,02341164 0,09391565 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02341164 0,09376169 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,02341164 0,09360823 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,02341164 0,09345528 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02341164 0,09330282 ! T cell activation during immune response GO:0002286 9 5 0,000 0,02341164 0,09315086 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02341164 0,0929994 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02341164 0,09284843 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,02341164 0,09269794 ! neuroprotection GO:0043526 8 5 0,000 0,02341164 0,09254795 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02341164 0,09239843 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02341164 0,0922494 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,02341164 0,09210085 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,02341164 0,09195278 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,02341164 0,09180519 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02341164 0,09165806 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,02341164 0,09151141 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02341164 0,09136522 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,02341164 0,09121951 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,02341164 0,09107425 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02341164 0,09092946 ! spindle assembly GO:0051225 6 5 0,000 0,02341164 0,09078513 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02341164 0,09064125 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02341164 0,09049783 ! protein palmitoylation GO:0018345 12 5 0,000 0,02341164 0,09035487 ! drug metabolic process GO:0017144 7 5 0,000 0,02341164 0,09021235 ! stem cell division GO:0017145 11 5 0,000 0,02341164 0,09007028 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,02341164 0,08992866 ! organ regeneration GO:0031100 7 5 0,000 0,02341164 0,08978749 ! carnitine metabolic process GO:0009437 8 5 0,000 0,02341164 0,08964676 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02341164 0,08950646 ! induction of apoptosis by extracellular signals GO:0008624 99 50 1,000 0,02345328 0,08952556 ! endocrine system development GO:0035270 109 50 1,000 0,02345328 0,08938589 ! activation of caspase activity GO:0006919 95 50 1,000 0,02345328 0,08924666 ! epidermal cell differentiation GO:0009913 87 50 1,000 0,02345328 0,08910786 ! viral infectious cycle GO:0019058 104 51 1,000 0,02433592 0,09231778 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,02433592 0,09217465 ! response to temperature stimulus GO:0009266 84 51 1,000 0,02433592 0,09203196 ! negative regulation of immune system process GO:0002683 101 51 1,000 0,02433592 0,09188972 ! positive regulation of binding GO:0051099 88 52 1,000 0,025232 0,0951262 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,025232 0,09497963 ! morphogenesis of embryonic epithelium GO:0016331 106 52 1,000 0,025232 0,09483351 ! histone modification GO:0016570 104 52 1,000 0,025232 0,09468783 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 1,000 0,02614138 0,09794999 ! vesicle organization GO:0016050 127 53 1,000 0,02614138 0,09779999 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,02706392 0,10109655 GO:0010863|positive regulation of phospholipase C activity, ! neuromuscular process GO:0050905 107 54 1,000 0,02706392 0,10094221 ! regulation of muscle contraction GO:0006937 94 54 1,000 0,02706392 0,10078833 ! membrane fusion GO:0006944 122 54 1,000 0,02706392 0,10063492 ! covalent chromatin modification GO:0016569 115 54 1,000 0,02706392 0,10048198 ! epithelial tube morphogenesis GO:0060562 114 54 1,000 0,02706392 0,10032951 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,02799946 0,10364042 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 1,000 0,02799946 0,10348363 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,02799946 0,10332731 ! cell maturation GO:0048469 107 55 1,000 0,02799946 0,10317146 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02802817 0,10312171 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02802817 0,10296663 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02802817 0,10281203 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02802817 0,10265789 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02802817 0,10250421 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02802817 0,10235099 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02802817 0,10219823 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02802817 0,10204592 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02802817 0,10189407 ! response to oxygen radical GO:0000305 11 6 0,000 0,02802817 0,10174266 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02802817 0,10159171 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02802817 0,1014412 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02802817 0,10129114 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02802817 0,10114152 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02802817 0,10099235 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02802817 0,10084361 ! forebrain regionalization GO:0021871 9 6 0,000 0,02802817 0,10069531 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02802817 0,10054745 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02802817 0,10040002 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02802817 0,10025302 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02802817 0,10010645 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,02802817 0,09996031 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02802817 0,0998146 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02802817 0,0996693 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02802817 0,09952444 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02802817 0,09937999 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02802817 0,09923596 ! malate metabolic process GO:0006108 13 6 0,000 0,02802817 0,09909235 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02802817 0,09894915 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02802817 0,09880637 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02802817 0,09866399 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02802817 0,09852203 ! protein refolding GO:0042026 15 6 0,000 0,02802817 0,09838048 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02802817 0,09823933 ! opsonization GO:0008228 8 6 0,000 0,02802817 0,09809858 ! mating behavior GO:0007617 7 6 0,000 0,02802817 0,09795824 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02802817 0,0978183 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02802817 0,09767876 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02802817 0,09753962 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02802817 0,09740087 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02802817 0,09726252 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02802817 0,09712456 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02802817 0,09698699 ! toxin metabolic process GO:0009404 11 6 0,000 0,02802817 0,09684981 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02802817 0,09671301 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02802817 0,0965766 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02802817 0,09644058 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02802817 0,09630494 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02802817 0,09616968 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02802817 0,0960348 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02802817 0,0959003 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02802817 0,09576617 ! thymic T cell selection GO:0045061 16 6 0,000 0,02802817 0,09563242 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02802817 0,09549904 ! protein lipoylation GO:0009249 10 6 0,000 0,02802817 0,09536603 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02802817 0,0952334 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02802817 0,09510113 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02802817 0,09496923 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02802817 0,09483769 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02802817 0,09470652 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02802817 0,09457571 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02802817 0,09444526 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02802817 0,09431517 ! hyperosmotic response GO:0006972 10 6 0,000 0,02802817 0,09418544 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02802817 0,09405606 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02802817 0,09392704 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02802817 0,09379837 ! urea metabolic process GO:0019627 7 6 0,000 0,02802817 0,09367006 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02802817 0,09354209 ! neutrophil activation GO:0042119 7 6 0,000 0,02802817 0,09341448 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02802817 0,09328721 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02802817 0,09316029 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02802817 0,09303371 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02802817 0,09290748 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02802817 0,09278159 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02802817 0,09265604 ! neuron apoptosis GO:0051402 15 6 0,000 0,02802817 0,09253083 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02802817 0,09240595 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02802817 0,09228142 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02802817 0,09215722 ! carnitine transport GO:0015879 10 6 0,000 0,02802817 0,09203335 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02802817 0,09190982 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02802817 0,09178661 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02802817 0,09166374 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02802817 0,09154119 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02802817 0,09141897 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02802817 0,09129708 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02802817 0,09117552 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02802817 0,09105427 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02802817 0,09093335 ! establishment of spindle localization GO:0051293 16 6 0,000 0,02802817 0,09081275 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02802817 0,09069247 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02802817 0,0905725 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,02802817 0,09045286 ! response to UV-C GO:0010225 14 6 0,000 0,02802817 0,09033353 ! astrocyte development GO:0014002 16 6 0,000 0,02802817 0,09021451 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02802817 0,09009581 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02802817 0,08997741 ! interaction with symbiont GO:0051702 14 6 0,000 0,02802817 0,08985933 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02802817 0,08974156 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02802817 0,0896241 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02802817 0,08950694 ! response to copper ion GO:0046688 10 6 0,000 0,02802817 0,08939009 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02802817 0,08927355 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02802817 0,08915731 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02802817 0,08904137 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02802817 0,08892573 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02802817 0,08881039 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02802817 0,08869535 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02802817 0,08858061 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02802817 0,08846617 ! Schwann cell development GO:0014044 15 6 0,000 0,02802817 0,08835202 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02802817 0,08823816 ! response to pheromone GO:0019236 6 6 0,000 0,02802817 0,0881246 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02802817 0,08801133 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02802817 0,08789835 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02802817 0,08778566 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02802817 0,08767326 ! subpallium development GO:0021544 15 6 0,000 0,02802817 0,08756114 ! neural tube patterning GO:0021532 8 6 0,000 0,02802817 0,08744931 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02802817 0,08733777 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02802817 0,08722651 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02802817 0,08711554 ! G2 phase GO:0051319 16 6 0,000 0,02802817 0,08700484 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02802817 0,08689443 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02802817 0,0867843 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02802817 0,08667445 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02802817 0,08656487 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02802817 0,08645557 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02802817 0,08634655 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02802817 0,0862378 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02802817 0,08612932 ! receptor internalization GO:0031623 11 6 0,000 0,02802817 0,08602112 ! plasminogen activation GO:0031639 9 6 0,000 0,02802817 0,08591319 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02802817 0,08580553 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02802817 0,08569814 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02802817 0,08559102 ! protein deubiquitination GO:0016579 16 6 0,000 0,02802817 0,08548416 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,02802817 0,08537757 ! protein destabilization GO:0031648 9 6 0,000 0,02802817 0,08527125 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02802817 0,08516519 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02802817 0,08505939 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02802817 0,08495386 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02802817 0,08484859 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02802817 0,08474358 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02802817 0,08463883 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02802817 0,08453434 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02802817 0,0844301 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02802817 0,08432612 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02802817 0,0842224 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02802817 0,08411893 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02802817 0,08401572 ! neural plate development GO:0001840 9 6 0,000 0,02802817 0,08391276 ! catecholamine transport GO:0051937 9 6 0,000 0,02802817 0,08381005 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02802817 0,08370759 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02802817 0,08360539 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02802817 0,08350343 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02802817 0,08340172 ! maternal placenta development GO:0001893 12 6 0,000 0,02802817 0,08330026 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02802817 0,08319904 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02802817 0,08309807 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02802817 0,08299735 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02802817 0,08289687 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02802817 0,08279663 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02802817 0,08269663 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,02894787 0,08530717 ! regulation of DNA replication GO:0006275 105 56 1,000 0,02894787 0,08520439 ! positive regulation of caspase activity GO:0043280 108 57 1,000 0,02990901 0,08792744 GO:0010952|positive regulation of peptidase activity, ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,02990901 0,08782176 ! heart morphogenesis GO:0003007 105 57 1,000 0,02990901 0,08771633 ! regulation of actin filament length GO:0030832 118 58 1,000 0,03088273 0,09046344 ! gastrulation GO:0007369 122 58 1,000 0,03088273 0,09035511 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,03088273 0,09024702 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,03088273 0,0901392 ! maintenance of location GO:0051235 124 58 1,000 0,03088273 0,09003164 ! tRNA transcription GO:0009304 17 7 0,000 0,032623 0,09499165 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,032623 0,09487857 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,032623 0,09476575 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,032623 0,0946532 ! regulation of helicase activity GO:0051095 16 7 0,000 0,032623 0,09454092 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,032623 0,0944289 ! sleep GO:0030431 16 7 0,000 0,032623 0,09431715 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,032623 0,09420567 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,032623 0,09409445 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,032623 0,09398349 ! prostate gland development GO:0030850 14 7 0,000 0,032623 0,09387279 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,032623 0,09376235 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,032623 0,09365217 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,032623 0,09354225 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,032623 0,09343259 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,032623 0,09332318 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,032623 0,09321403 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,032623 0,09310514 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,032623 0,09299649 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,032623 0,09288811 ! glycolipid transport GO:0046836 11 7 0,000 0,032623 0,09277997 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,032623 0,09267209 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,032623 0,09256445 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,032623 0,09245707 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,032623 0,09234994 ! mRNA stabilization GO:0048255 18 7 0,000 0,032623 0,09224305 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,032623 0,09213641 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,032623 0,09203002 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,032623 0,09192387 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,032623 0,09181797 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,032623 0,09171231 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,032623 0,09160689 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,032623 0,09150172 ! lipoprotein transport GO:0042953 14 7 0,000 0,032623 0,09139678 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,032623 0,09129209 ! rhythmic behavior GO:0007622 17 7 0,000 0,032623 0,09118764 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,032623 0,09108342 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,032623 0,09097945 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,032623 0,09087571 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,032623 0,0907722 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,032623 0,09066894 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,032623 0,0905659 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,032623 0,09046311 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,032623 0,09036054 ! mechanosensory behavior GO:0007638 16 7 0,000 0,032623 0,09025821 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,032623 0,0901561 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,032623 0,09005423 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,032623 0,08995259 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,032623 0,08985118 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,032623 0,08975 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,032623 0,08964904 ! spinal cord patterning GO:0021511 14 7 0,000 0,032623 0,08954831 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,032623 0,08944781 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,032623 0,08934753 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,032623 0,08924748 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,032623 0,08914765 ! adrenal gland development GO:0030325 17 7 0,000 0,032623 0,08904804 ! cysteine metabolic process GO:0006534 13 7 0,000 0,032623 0,08894866 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,032623 0,08884949 ! ovulation GO:0030728 10 7 0,000 0,032623 0,08875055 ! adenohypophysis development GO:0021984 11 7 0,000 0,032623 0,08865183 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,032623 0,08855333 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,032623 0,08845505 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,032623 0,08835698 ! microtubule nucleation GO:0007020 21 7 0,000 0,032623 0,08825913 ! proline biosynthetic process GO:0006561 10 7 0,000 0,032623 0,0881615 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,032623 0,08806408 ! thyroid hormone generation GO:0006590 13 7 0,000 0,032623 0,08796688 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,032623 0,0878699 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,032623 0,08777312 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,032623 0,08767656 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,032623 0,08758021 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,032623 0,08748408 ! galactose metabolic process GO:0006012 13 7 0,000 0,032623 0,08738815 ! response to dietary excess GO:0002021 8 7 0,000 0,032623 0,08729244 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,032623 0,08719693 ! intracellular pH reduction GO:0051452 13 7 0,000 0,032623 0,08710163 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,032623 0,08700655 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,032623 0,08691166 ! organ growth GO:0035265 15 7 0,000 0,032623 0,08681699 ! nucleoside transport GO:0015858 11 7 0,000 0,032623 0,08672252 ! nucleoside salvage GO:0043174 11 7 0,000 0,032623 0,08662826 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,032623 0,0865342 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,032623 0,08644034 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,032623 0,08634669 ! parturition GO:0007567 16 7 0,000 0,032623 0,08625324 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,032623 0,08616 ! rRNA modification GO:0000154 14 7 0,000 0,032623 0,08606695 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,032623 0,08597411 ! spindle checkpoint GO:0031577 16 7 0,000 0,032623 0,08588146 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,032623 0,08578902 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,032623 0,08569677 ! monocyte differentiation GO:0030224 16 7 0,000 0,032623 0,08560472 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,032623 0,08551287 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,032623 0,08542122 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,032623 0,08532976 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,032623 0,0852385 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,032623 0,08514743 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,032623 0,08505656 ! fibrinolysis GO:0042730 11 7 0,000 0,032623 0,08496588 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,032623 0,08487539 ! eating behavior GO:0042755 8 7 0,000 0,032623 0,0847851 ! B cell lineage commitment GO:0002326 21 7 0,000 0,032623 0,084695 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,032623 0,08460509 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,032623 0,08451537 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,032623 0,08442584 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,032623 0,0843365 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,032623 0,08424735 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,032623 0,08415839 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,032623 0,08406962 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,032623 0,08398103 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,032623 0,08389263 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,032623 0,08380441 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,032623 0,08371638 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,032623 0,08362854 ! histone ubiquitination GO:0016574 9 7 0,000 0,032623 0,08354088 ! regulation of meiosis GO:0040020 12 7 0,000 0,032623 0,0834534 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,032623 0,0833661 ! T cell lineage commitment GO:0002360 16 7 0,000 0,032623 0,08327899 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,032623 0,08319206 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,032623 0,08310531 ! membrane to membrane docking GO:0022614 14 7 0,000 0,032623 0,08301875 ! transcription termination GO:0006353 14 7 0,000 0,032623 0,08293236 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,032623 0,08284615 ! anaphase GO:0051322 18 7 0,000 0,032623 0,08276012 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,032623 0,08267427 ! axonal fasciculation GO:0007413 19 7 0,000 0,032623 0,0825886 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,032623 0,0825031 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,032623 0,08241778 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,032623 0,08233264 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,032623 0,08224767 ! diuresis GO:0030146 12 7 0,000 0,032623 0,08216288 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,032623 0,08207827 ! thiamin metabolic process GO:0006772 7 7 0,000 0,032623 0,08199382 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,032623 0,08190955 ! antibiotic transport GO:0042891 9 7 0,000 0,032623 0,08182546 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,032623 0,08174153 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,032623 0,08165778 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,032623 0,0815742 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,032623 0,08149079 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,032623 0,08140755 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,032623 0,08132449 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,032623 0,08124159 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,032623 0,08115886 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,032623 0,08107629 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,032623 0,0809939 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,032623 0,08091167 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,032623 0,08082961 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,032623 0,08074772 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,032623 0,08066599 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,032623 0,08058442 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,032623 0,08050303 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,032623 0,08042179 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,032623 0,08034072 ! muscle adaptation GO:0043500 13 7 0,000 0,032623 0,08025981 ! embryonic heart tube development GO:0035050 14 7 0,000 0,032623 0,08017907 ! retina homeostasis GO:0001895 12 7 0,000 0,032623 0,08009849 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,032623 0,08001807 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,032623 0,07993781 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,032623 0,07985771 ! regulation of endocytosis GO:0030100 104 60 1,000 0,03286739 0,0803754 ! adult behavior GO:0030534 104 60 1,000 0,03286739 0,08029503 ! regulation of cellular component size GO:0032535 125 61 1,000 0,03387804 0,08268138 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,03387804 0,08259886 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,03719625 0,09059863 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,03719625 0,09050839 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,03719625 0,09041834 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,03719625 0,09032846 GO:0016446|somatic hypermutation of immunoglobulin genes, ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,03719625 0,09023876 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,03719625 0,09014923 ! male meiosis GO:0007140 9 8 0,000 0,03719625 0,09005989 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,03719625 0,08997072 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,03719625 0,08988173 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,03719625 0,08979291 ! meiotic prophase I GO:0007128 14 8 0,000 0,03719625 0,08970427 ! response to zinc ion GO:0010043 12 8 0,000 0,03719625 0,08961581 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,03719625 0,08952752 ! oligopeptide transport GO:0006857 16 8 0,000 0,03719625 0,0894394 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,03719625 0,08935145 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,03719625 0,08926368 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,03719625 0,08917608 ! signal peptide processing GO:0006465 12 8 0,000 0,03719625 0,08908866 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,03719625 0,0890014 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,03719625 0,08891431 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,03719625 0,0888274 ! succinate metabolic process GO:0006105 17 8 0,000 0,03719625 0,08874065 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,03719625 0,08865408 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,03719625 0,08856767 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,03719625 0,08848143 ! estrogen metabolic process GO:0008210 17 8 0,000 0,03719625 0,08839536 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,03719625 0,08830945 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,03719625 0,08822372 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,03719625 0,08813815 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,03719625 0,08805274 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03719625 0,0879675 ! reflex GO:0060004 17 8 0,000 0,03719625 0,08788243 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,03719625 0,08779752 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,03719625 0,08771277 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,03719625 0,08762819 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,03719625 0,08754377 ! pigment granule organization GO:0048753 17 8 0,000 0,03719625 0,08745951 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,03719625 0,08737541 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,03719625 0,08729148 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,03719625 0,0872077 ! astrocyte differentiation GO:0048708 19 8 0,000 0,03719625 0,08712409 ! histidine catabolic process GO:0006548 10 8 0,000 0,03719625 0,08704064 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,03719625 0,08695735 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,03719625 0,08687421 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,03719625 0,08679124 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,03719625 0,08670842 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,03719625 0,08662577 ! melanin metabolic process GO:0006582 17 8 0,000 0,03719625 0,08654326 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,03719625 0,08646092 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,03719625 0,08637873 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,03719625 0,0862967 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,03719625 0,08621483 ! macrophage activation GO:0042116 13 8 0,000 0,03719625 0,08613311 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,03719625 0,08605154 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,03719625 0,08597013 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,03719625 0,08588887 ! purine salvage GO:0043101 12 8 0,000 0,03719625 0,08580777 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,03719625 0,08572682 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03719625 0,08564602 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,03719625 0,08556537 ! osteoblast development GO:0002076 17 8 0,000 0,03719625 0,08548488 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,03719625 0,08540454 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,03719625 0,08532435 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,03719625 0,0852443 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,03719625 0,08516441 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,03719625 0,08508467 ! response to UV-B GO:0010224 17 8 0,000 0,03719625 0,08500508 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,03719625 0,08492563 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,03719625 0,08484634 ! intermediate filament organization GO:0045109 12 8 0,000 0,03719625 0,08476719 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,03719625 0,08468819 ! cellular extravasation GO:0045123 13 8 0,000 0,03719625 0,08460934 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,03719625 0,08453063 ! response to antibiotic GO:0046677 11 8 0,000 0,03719625 0,08445207 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,03719625 0,08437366 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,03719625 0,08429539 ! DNA topological change GO:0006265 12 8 0,000 0,03719625 0,08421726 ! response to tropane GO:0014073 15 8 0,000 0,03719625 0,08413929 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,03719625 0,08406145 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,03719625 0,08398376 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,03719625 0,08390621 ! mast cell activation GO:0045576 14 8 0,000 0,03719625 0,08382881 ! multicellular organismal aging GO:0010259 20 8 0,000 0,03719625 0,08375155 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,03719625 0,08367443 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,03719625 0,08359745 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,03719625 0,08352061 ! nucleosome disassembly GO:0006337 14 8 0,000 0,03719625 0,08344392 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,03719625 0,08336737 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,03719625 0,08329095 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,03719625 0,08321468 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,03719625 0,08313854 ! intracellular lipid transport GO:0032365 16 8 0,000 0,03719625 0,08306255 ! response to tumor cell GO:0002347 16 8 0,000 0,03719625 0,08298669 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,03719625 0,08291097 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,03719625 0,08283539 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,03719625 0,08275995 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,03719625 0,08268465 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,03719625 0,08260948 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,03719625 0,08253445 ! hormone catabolic process GO:0042447 17 8 0,000 0,03719625 0,08245955 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,03719625 0,08238479 GO:0046479|glycosphingolipid catabolic process, ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,03719625 0,08231017 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,03719625 0,08223568 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,03719625 0,08216133 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,03719625 0,08208711 ! adult feeding behavior GO:0008343 10 8 0,000 0,03719625 0,08201302 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,03719625 0,08193907 ! ATP catabolic process GO:0006200 11 8 0,000 0,03719625 0,08186525 ! blastocyst growth GO:0001832 19 8 0,000 0,03719625 0,08179156 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,03719625 0,08171801 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,03719625 0,08164459 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,03719625 0,0815713 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,03719625 0,08149814 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,03719625 0,08142511 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,03719625 0,08135222 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,03719625 0,08127945 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,03719625 0,08120682 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,03719625 0,08113431 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,03719625 0,08106193 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,03719625 0,08098969 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,03719625 0,08091757 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,03719625 0,08084558 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,03719625 0,08077371 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,03719625 0,08070198 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,03719625 0,08063037 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,03719625 0,08055889 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,03719625 0,08048754 ! gonad development GO:0008406 115 66 1,000 0,0391092 0,08455201 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,04019008 0,08681198 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,04128219 0,08909223 ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,04128219 0,08901359 ! regulation of lipase activity GO:0060191 137 68 1,000 0,04128219 0,0889351 ! axon extension GO:0048675 16 9 0,000 0,041748 0,08985934 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,041748 0,08978024 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,041748 0,08970128 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,041748 0,08962246 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,041748 0,08954377 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,041748 0,08946522 ! reproductive behavior GO:0019098 22 9 0,000 0,041748 0,08938682 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,041748 0,08930854 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,041748 0,08923041 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,041748 0,08915241 ! UTP metabolic process GO:0046051 10 9 0,000 0,041748 0,08907455 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,041748 0,08899682 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,041748 0,08891923 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,041748 0,08884177 ! artery development GO:0060840 25 9 0,000 0,041748 0,08876445 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,041748 0,08868727 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,041748 0,08861021 ! equilibrioception GO:0050957 20 9 0,000 0,041748 0,0885333 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,041748 0,08845651 ! chemosensory behavior GO:0007635 21 9 0,000 0,041748 0,08837986 ! microtubule bundle formation GO:0001578 22 9 0,000 0,041748 0,08830334 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,041748 0,08822695 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,041748 0,0881507 ! leukocyte degranulation GO:0043299 16 9 0,000 0,041748 0,08807457 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,041748 0,08799858 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,041748 0,08792272 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,041748 0,08784699 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,041748 0,08777139 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,041748 0,08769592 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,041748 0,08762058 ! protein targeting to ER GO:0045047 25 9 0,000 0,041748 0,08754537 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,041748 0,08747029 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,041748 0,08739534 ! T cell selection GO:0045058 27 9 0,000 0,041748 0,08732051 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,041748 0,08724581 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,041748 0,08717124 ! endosome organization GO:0007032 20 9 0,000 0,041748 0,0870968 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,041748 0,08702249 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,041748 0,0869483 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,041748 0,08687424 ! mannose metabolic process GO:0006013 13 9 0,000 0,041748 0,0868003 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,041748 0,08672649 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,041748 0,08665281 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,041748 0,08657925 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,041748 0,08650582 ! receptor clustering GO:0043113 20 9 0,000 0,041748 0,08643251 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,041748 0,08635932 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,041748 0,08628626 ! retinol metabolic process GO:0042572 20 9 0,000 0,041748 0,08621332 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,041748 0,0861405 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,041748 0,08606781 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,041748 0,08599524 ! oligodendrocyte development GO:0014003 11 9 0,000 0,041748 0,08592279 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,041748 0,08585047 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,041748 0,08577826 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,041748 0,08570618 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,041748 0,08563422 ! response to amine stimulus GO:0014075 13 9 0,000 0,041748 0,08556238 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,041748 0,08549066 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,041748 0,08541906 ! erythrocyte development GO:0048821 17 9 0,000 0,041748 0,08534758 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,041748 0,08527622 ! renal water homeostasis GO:0003091 15 9 0,000 0,041748 0,08520498 ! postreplication repair GO:0006301 25 9 0,000 0,041748 0,08513385 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,041748 0,08506285 ! icosanoid secretion GO:0032309 15 9 0,000 0,041748 0,08499196 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,041748 0,0849212 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,041748 0,08485055 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,041748 0,08478001 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,041748 0,0847096 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,041748 0,0846393 ! sterol catabolic process GO:0016127 14 9 0,000 0,041748 0,08456912 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,041748 0,08449905 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,041748 0,0844291 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,041748 0,08435927 ! S phase GO:0051320 10 9 0,000 0,041748 0,08428955 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,041748 0,08421995 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,041748 0,08415046 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,041748 0,08408109 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,041748 0,08401183 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,041748 0,08394268 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,041748 0,08387365 ! purine base metabolic process GO:0006144 25 9 0,000 0,041748 0,08380473 ! pigment granule transport GO:0051904 17 9 0,000 0,041748 0,08373592 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,041748 0,08366723 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,041748 0,08359865 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,041748 0,08353019 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,041748 0,08346183 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,041748 0,08339359 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,041748 0,08332545 ! mitochondrion localization GO:0051646 18 9 0,000 0,041748 0,08325743 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,04238543 0,0844597 ! cellular amino acid catabolic process GO:0009063 120 69 1,000 0,04238543 0,08439087 ! cell redox homeostasis GO:0045454 114 70 1,000 0,04349965 0,08653879 ! germ cell development GO:0007281 133 70 1,000 0,04349965 0,08646838 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,04462472 0,08863268 ! carbohydrate transport GO:0008643 114 72 1,000 0,04576053 0,09081477 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,04627836 0,09176788 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 0,000 0,04627836 0,09169345 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,04627836 0,09161915 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,04627836 0,09154496 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,04627836 0,09147089 ! associative learning GO:0008306 21 10 0,000 0,04627836 0,09139695 ! positive regulation of B cell proliferation GO:0030890 18 10 0,000 0,04627836 0,09132312 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,04627836 0,09124942 ! phosphate transport GO:0006817 24 10 0,000 0,04627836 0,09117583 ! cell volume homeostasis GO:0006884 17 10 0,000 0,04627836 0,09110236 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,04627836 0,09102901 ! CTP metabolic process GO:0046036 11 10 0,000 0,04627836 0,09095577 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,04627836 0,09088266 ! GTP metabolic process GO:0046039 11 10 0,000 0,04627836 0,09080966 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,04627836 0,09073678 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,04627836 0,09066401 ! social behavior GO:0035176 29 10 0,000 0,04627836 0,09059137 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,04627836 0,09051884 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,04627836 0,09044642 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,04627836 0,09037412 ! androgen metabolic process GO:0008209 17 10 0,000 0,04627836 0,09030194 ! phospholipid efflux GO:0033700 19 10 0,000 0,04627836 0,09022987 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,04627836 0,09015792 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,04627836 0,09008608 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,04627836 0,09001435 ! lung alveolus development GO:0048286 26 10 0,000 0,04627836 0,08994274 ! pathogenesis GO:0009405 17 10 0,000 0,04627836 0,08987124 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04627836 0,08979986 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,04627836 0,08972859 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,04627836 0,08965743 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,04627836 0,08958639 ! endoderm development GO:0007492 18 10 0,000 0,04627836 0,08951546 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,04627836 0,08944464 ! arginine catabolic process GO:0006527 17 10 0,000 0,04627836 0,08937393 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,04627836 0,08930334 ! proline metabolic process GO:0006560 13 10 0,000 0,04627836 0,08923285 ! phosphagen metabolic process GO:0006599 17 10 0,000 0,04627836 0,08916248 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,04627836 0,08909222 ! V(D)J recombination GO:0033151 34 10 0,000 0,04627836 0,08902207 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,04627836 0,08895203 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,04627836 0,0888821 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,04627836 0,08881227 ! B cell proliferation GO:0042100 19 10 0,000 0,04627836 0,08874256 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,04627836 0,08867296 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,04627836 0,08860347 ! multicellular organism growth GO:0035264 19 10 0,000 0,04627836 0,08853408 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,04627836 0,08846481 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,04627836 0,08839564 ! ruffle organization GO:0031529 17 10 0,000 0,04627836 0,08832658 ! epithelial cell development GO:0002064 21 10 0,000 0,04627836 0,08825763 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,04627836 0,08818879 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,04627836 0,08812005 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,04627836 0,08805142 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,04627836 0,0879829 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,04627836 0,08791448 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,04627836 0,08784617 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,04627836 0,08777797 ! motor axon guidance GO:0008045 22 10 0,000 0,04627836 0,08770987 ! copper ion homeostasis GO:0055070 13 10 0,000 0,04627836 0,08764188 ! regulation of bone resorption GO:0045124 25 10 0,000 0,04627836 0,08757399 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,04627836 0,08750621 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,04627836 0,08743853 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,04627836 0,08737096 ! segment specification GO:0007379 15 10 0,000 0,04627836 0,08730349 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,04627836 0,08723613 ! blastoderm segmentation GO:0007350 19 10 0,000 0,04627836 0,08716887 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,04627836 0,08710171 ! response to dsRNA GO:0043331 23 10 0,000 0,04627836 0,08703466 ! DNA ligation GO:0006266 18 10 0,000 0,04627836 0,08696771 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,04627836 0,08690087 ! melanosome localization GO:0032400 16 10 0,000 0,04627836 0,08683412 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,04627836 0,08676748 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,04627836 0,08670094 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,04627836 0,0866345 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,04627836 0,08656817 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,04627836 0,08650193 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,04627836 0,0864358 ! protein sumoylation GO:0016925 17 10 0,000 0,04627836 0,08636977 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,04627836 0,08630384 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,04627836 0,08623801 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,04627836 0,08617228 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,04627836 0,08610665 ! salivary gland development GO:0007431 28 10 0,000 0,04627836 0,08604112 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,04627836 0,08597568 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,04627836 0,08591035 ! musculoskeletal movement GO:0050881 16 10 0,000 0,04627836 0,08584512 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,04627836 0,08577999 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,04627836 0,08571495 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,04627836 0,08565002 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,04627836 0,08558518 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,04627836 0,08552044 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,04627836 0,0854558 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,04627836 0,08539126 ! detection of calcium ion GO:0005513 24 10 0,000 0,04627836 0,08532681 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,04627836 0,08526246 ! blastocyst formation GO:0001825 18 10 0,000 0,04627836 0,08519821 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,04627836 0,08513406 ! cerebellar cortex development GO:0021695 16 10 0,000 0,04627836 0,08507 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,04627836 0,08500603 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,04627836 0,08494217 ! response to nicotine GO:0035094 20 10 0,000 0,04627836 0,0848784 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,04627836 0,08481472 ! regulation of immune effector process GO:0002697 156 73 1,000 0,04690695 0,0859023 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,04923111 0,09009108 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 1,000 0,04923111 0,09002365 ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,04923111 0,08995631 ! regulation of actin cytoskeleton organization GO:0032956 167 76 1,000 0,0504086 0,09203902 ! regulation of blood pressure GO:0008217 134 76 1,000 0,0504086 0,09197029 ! lymphocyte differentiation GO:0030098 193 76 1,000 0,0504086 0,09190165 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,0504086 0,09183312 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,05078743 0,09245431 ! respiratory burst GO:0045730 17 11 0,000 0,05078743 0,09238547 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,05078743 0,09231673 ! neuron fate specification GO:0048665 18 11 0,000 0,05078743 0,09224809 ! telencephalon cell migration GO:0022029 23 11 0,000 0,05078743 0,09217955 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,05078743 0,09211112 ! synapsis GO:0007129 14 11 0,000 0,05078743 0,09204279 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,05078743 0,09197456 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,05078743 0,09190643 ! response to pain GO:0048265 27 11 0,000 0,05078743 0,0918384 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,05078743 0,09177047 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,05078743 0,09170265 ! blood vessel remodeling GO:0001974 30 11 0,000 0,05078743 0,09163492 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,05078743 0,09156729 ! bone resorption GO:0045453 16 11 0,000 0,05078743 0,09149976 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,05078743 0,09143234 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,05078743 0,09136501 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,05078743 0,09129778 ! melanocyte differentiation GO:0030318 20 11 0,000 0,05078743 0,09123065 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,05078743 0,09116361 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,05078743 0,09109668 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,05078743 0,09102985 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,05078743 0,09096311 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,05078743 0,09089647 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,05078743 0,09082993 ! UV protection GO:0009650 20 11 0,000 0,05078743 0,09076348 ! adult heart development GO:0007512 16 11 0,000 0,05078743 0,09069713 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,05078743 0,09063088 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,05078743 0,09056473 ! macroautophagy GO:0016236 19 11 0,000 0,05078743 0,09049867 ! temperature homeostasis GO:0001659 18 11 0,000 0,05078743 0,09043271 ! behavioral fear response GO:0001662 27 11 0,000 0,05078743 0,09036685 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,05078743 0,09030108 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,05078743 0,0902354 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,05078743 0,09016983 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,05078743 0,09010434 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,05078743 0,09003895 ! regulation of organ growth GO:0046620 14 11 0,000 0,05078743 0,08997366 ! pigment granule localization GO:0051875 20 11 0,000 0,05078743 0,08990846 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,05078743 0,08984336 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,05078743 0,08977835 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,05078743 0,08971343 ! embryonic axis specification GO:0000578 19 11 0,000 0,05078743 0,08964861 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,05078743 0,08958388 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,05078743 0,08951925 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,05078743 0,08945471 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,05078743 0,08939026 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,05078743 0,0893259 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,05078743 0,08926164 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,05078743 0,08919747 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,05078743 0,08913339 ! prophase GO:0051324 17 11 0,000 0,05078743 0,0890694 ! nucleosome positioning GO:0016584 15 11 0,000 0,05078743 0,08900551 ! regulation of isotype switching GO:0045191 24 11 0,000 0,05078743 0,08894171 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,05078743 0,08887799 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,05078743 0,08881437 ! apical protein localization GO:0045176 18 11 0,000 0,05078743 0,08875084 ! acid secretion GO:0046717 20 11 0,000 0,05078743 0,0886874 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,05078743 0,08862406 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,05078743 0,0885608 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,05078743 0,08849763 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,05078743 0,08843455 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,05078743 0,08837157 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,05078743 0,08830867 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,05078743 0,08824586 ! cholesterol efflux GO:0033344 21 11 0,000 0,05078743 0,08818314 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,05078743 0,08812051 ! oocyte development GO:0048599 20 11 0,000 0,05078743 0,08805797 ! germ cell migration GO:0008354 26 11 0,000 0,05078743 0,08799552 ! embryonic gut development GO:0048566 19 11 0,000 0,05078743 0,08793315 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,05078743 0,08787088 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,05078743 0,08780869 ! activation of innate immune response GO:0002218 16 11 0,000 0,05078743 0,08774659 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,05078743 0,08768458 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,05078743 0,08762266 ! lysogeny GO:0030069 22 11 0,000 0,05078743 0,08756082 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,05078743 0,08749907 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,05078743 0,08743741 ! sequestering of metal ion GO:0051238 15 11 0,000 0,05078743 0,08737583 ! amine catabolic process GO:0009310 136 77 1,000 0,05159621 0,08870482 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,05159621 0,08864244 ! antigen processing and presentation GO:0019882 117 78 1,000 0,05279382 0,09063619 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,05279382 0,09057254 ! regulation of actin filament-based process GO:0032970 170 79 1,000 0,0540013 0,09257907 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,05521854 0,0945995 ! development of primary sexual characteristics GO:0045137 143 80 1,000 0,05521854 0,09453321 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,05521854 0,09446701 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,0552753 0,09449794 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,0552753 0,09443186 ! regulation of B cell proliferation GO:0030888 22 12 0,000 0,0552753 0,09436587 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,0552753 0,09429997 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,0552753 0,09423417 ! protein complex disassembly GO:0043241 28 12 0,000 0,0552753 0,09416845 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,0552753 0,09410283 ! hippocampus development GO:0021766 29 12 0,000 0,0552753 0,0940373 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,0552753 0,09397186 ! T cell proliferation GO:0042098 32 12 0,000 0,0552753 0,09390651 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,0552753 0,09384125 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,0552753 0,09377608 ! ventral spinal cord development GO:0021517 25 12 0,000 0,0552753 0,09371101 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,0552753 0,09364602 ! drug transport GO:0015893 16 12 0,000 0,0552753 0,09358112 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,0552753 0,09351632 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,0552753 0,0934516 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,0552753 0,09338697 ! polyamine metabolic process GO:0006595 18 12 0,000 0,0552753 0,09332243 ! focal adhesion formation GO:0048041 37 12 0,000 0,0552753 0,09325798 ! mitotic spindle organization GO:0007052 23 12 0,000 0,0552753 0,09319362 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,0552753 0,09312935 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,0552753 0,09306517 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,0552753 0,09300108 ! lipid digestion GO:0044241 21 12 0,000 0,0552753 0,09293707 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,0552753 0,09287315 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0552753 0,09280932 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,0552753 0,09274558 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,0552753 0,09268192 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,0552753 0,09261836 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,0552753 0,09255487 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,0552753 0,09249148 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,0552753 0,09242817 ! snRNA metabolic process GO:0016073 30 12 0,000 0,0552753 0,09236495 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,0552753 0,09230182 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,0552753 0,09223877 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,0552753 0,09217581 ! cranial nerve development GO:0021545 23 12 0,000 0,0552753 0,09211293 ! fucose catabolic process GO:0019317 25 12 0,000 0,0552753 0,09205014 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,0552753 0,09198744 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,0552753 0,09192482 ! zymogen activation GO:0031638 18 12 0,000 0,0552753 0,09186229 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,0552753 0,09179984 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,0552753 0,09173747 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,0552753 0,09167519 ! oocyte differentiation GO:0009994 21 12 0,000 0,0552753 0,091613 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,0552753 0,09155089 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,0552753 0,09148886 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,0552753 0,09142692 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,0552753 0,09136506 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,0552753 0,09130329 ! defense response to fungus GO:0050832 15 12 0,000 0,0552753 0,0912416 ! embryonic placenta development GO:0001892 21 12 0,000 0,0552753 0,09117999 ! lamellipodium assembly GO:0030032 24 12 0,000 0,0552753 0,09111846 ! response to cold GO:0009409 17 12 0,000 0,0552753 0,09105702 ! establishment of cell polarity GO:0030010 21 12 0,000 0,0552753 0,09099566 ! regulation of synapse organization GO:0050807 18 12 0,000 0,0552753 0,09093438 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,05644541 0,09279687 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,05768181 0,09476575 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,05892761 0,09674742 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,05974208 0,09801875 ! cGMP metabolic process GO:0046068 18 13 0,000 0,05974208 0,09795296 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,05974208 0,09788727 ! regulation of chemokine production GO:0032642 18 13 0,000 0,05974208 0,09782166 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,05974208 0,09775614 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,05974208 0,09769071 ! peroxisomal transport GO:0043574 28 13 0,000 0,05974208 0,09762536 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,05974208 0,0975601 ! cartilage condensation GO:0001502 22 13 0,000 0,05974208 0,09749493 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,05974208 0,09742985 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,05974208 0,09736485 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,05974208 0,09729994 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,05974208 0,09723512 ! endocrine pancreas development GO:0031018 25 13 0,000 0,05974208 0,09717038 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,05974208 0,09710573 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,05974208 0,09704117 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,05974208 0,09697669 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,05974208 0,09691229 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,05974208 0,09684799 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,05974208 0,09678376 ! methionine metabolic process GO:0006555 31 13 0,000 0,05974208 0,09671962 ! plasma membrane organization GO:0007009 27 13 0,000 0,05974208 0,09665557 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,05974208 0,0965916 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,05974208 0,09652772 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,05974208 0,09646392 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,05974208 0,09640021 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,05974208 0,09633658 ! cytokine metabolic process GO:0042107 24 13 0,000 0,05974208 0,09627303 ! exocrine system development GO:0035272 34 13 0,000 0,05974208 0,09620957 ! asymmetric protein localization GO:0008105 24 13 0,000 0,05974208 0,09614619 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,05974208 0,09608289 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,05974208 0,09601968 ! L-glutamate transport GO:0015813 30 13 0,000 0,05974208 0,09595655 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,05974208 0,0958935 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,05974208 0,09583054 ! protein homotetramerization GO:0051289 24 13 0,000 0,05974208 0,09576766 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,05974208 0,09570486 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,05974208 0,09564215 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,05974208 0,09557951 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,05974208 0,09551696 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,05974208 0,09545449 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,05974208 0,0953921 ! histone methylation GO:0016571 29 13 0,000 0,05974208 0,09532979 ! chromatin silencing GO:0006342 29 13 0,000 0,05974208 0,09526757 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,05974208 0,09520542 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,05974208 0,09514336 ! regulation of epidermis development GO:0045682 19 13 0,000 0,05974208 0,09508138 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,05974208 0,09501947 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,05974208 0,09495765 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,05974208 0,09489591 ! spleen development GO:0048536 24 13 0,000 0,05974208 0,09483425 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,05974208 0,09477267 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,05974208 0,09471117 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,05974208 0,09464975 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,05974208 0,09458841 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,05974208 0,09452715 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,05974208 0,09446596 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,05974208 0,09440486 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,05974208 0,09434384 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,05974208 0,09428289 ! insulin secretion GO:0030073 24 13 0,000 0,05974208 0,09422202 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,05974208 0,09416123 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,05974208 0,09410052 ! acrosome reaction GO:0007340 19 13 0,000 0,05974208 0,09403989 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,05974208 0,09397934 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,05974208 0,09391886 ! T cell activation GO:0042110 189 84 1,000 0,06018271 0,09455071 ! negative regulation of growth GO:0045926 168 85 1,000 0,06144697 0,09647491 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,0627203 0,09841085 GO:0002696|positive regulation of leukocyte activation, ! mitochondrion organization GO:0007005 159 87 1,000 0,06400258 0,10035834 ! rRNA transcription GO:0009303 28 14 0,000 0,06418787 0,10058433 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,06418787 0,10051986 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,06418787 0,10045546 ! water transport GO:0006833 21 14 0,000 0,06418787 0,10039115 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,06418787 0,10032692 ! non-recombinational repair GO:0000726 29 14 0,000 0,06418787 0,10026277 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,06418787 0,10019871 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,06418787 0,10013472 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,06418787 0,10007082 ! RNA polyadenylation GO:0043631 32 14 0,000 0,06418787 0,100007 ! palate development GO:0060021 32 14 0,000 0,06418787 0,09994326 ! regulated secretory pathway GO:0045055 24 14 0,000 0,06418787 0,0998796 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,06418787 0,09981603 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,06418787 0,09975253 ! arginine metabolic process GO:0006525 21 14 0,000 0,06418787 0,09968911 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,06418787 0,09962578 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,06418787 0,09956252 ! regulation of heart rate GO:0002027 25 14 0,000 0,06418787 0,09949935 ! fear response GO:0042596 34 14 0,000 0,06418787 0,09943626 ! organic alcohol transport GO:0015850 29 14 0,000 0,06418787 0,09937324 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,06418787 0,09931031 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,06418787 0,09924745 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,06418787 0,09918468 ! neutral amino acid transport GO:0015804 28 14 0,000 0,06418787 0,09912198 ! bone mineralization GO:0030282 18 14 0,000 0,06418787 0,09905937 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,06418787 0,09899683 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,06418787 0,09893437 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,06418787 0,09887199 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,06418787 0,09880969 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,06418787 0,09874747 ! regulation of cellular pH GO:0030641 27 14 0,000 0,06418787 0,09868532 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,06418787 0,09862326 ! ribosome assembly GO:0042255 18 14 0,000 0,06418787 0,09856127 ! cerebellum development GO:0021549 23 14 0,000 0,06418787 0,09849936 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,06418787 0,09843752 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,06418787 0,09837577 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,06418787 0,09831409 ! response to gamma radiation GO:0010332 30 14 0,000 0,06418787 0,09825249 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,06418787 0,09819097 ! NADP metabolic process GO:0006739 24 14 0,000 0,06418787 0,09812952 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,06418787 0,09806815 ! oxygen transport GO:0015671 22 14 0,000 0,06418787 0,09800686 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,06418787 0,09794564 ! male genitalia development GO:0030539 26 14 0,000 0,06418787 0,0978845 ! regulation of axon extension GO:0030516 43 14 0,000 0,06418787 0,09782344 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,06418787 0,09776245 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,06418787 0,09770154 ! regulation of DNA binding GO:0051101 167 89 1,000 0,06659353 0,10130013 ! tube morphogenesis GO:0035239 194 89 1,000 0,06659353 0,10123709 ! regulation of neurological system process GO:0031644 175 89 1,000 0,06659353 0,10117413 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,06861277 0,10417712 ! lactation GO:0007595 30 15 0,000 0,06861277 0,10411242 ! reproductive cellular process GO:0048610 22 15 0,000 0,06861277 0,10404779 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,06861277 0,10398324 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,06861277 0,10391878 ! superoxide anion generation GO:0042554 22 15 0,000 0,06861277 0,10385439 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,06861277 0,10379009 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,06861277 0,10372586 ! copper ion transport GO:0006825 22 15 0,000 0,06861277 0,10366171 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,06861277 0,10359764 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,06861277 0,10353366 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,06861277 0,10346975 ! response to cAMP GO:0051591 25 15 0,000 0,06861277 0,10340592 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,06861277 0,10334216 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,06861277 0,10327849 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,06861277 0,10321489 ! response to hexose stimulus GO:0009746 25 15 0,000 0,06861277 0,10315138 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,06861277 0,10308794 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,06861277 0,10302458 ! vesicle coating GO:0006901 38 15 0,000 0,06861277 0,1029613 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,06861277 0,10289809 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,06861277 0,10283496 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,06861277 0,10277191 ! regulation of exocytosis GO:0017157 26 15 0,000 0,06861277 0,10270894 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,06861277 0,10264604 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,06861277 0,10258322 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,06861277 0,10252048 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,06861277 0,10245782 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,06861277 0,10239523 ! histone deacetylation GO:0016575 24 15 0,000 0,06861277 0,10233272 ! water homeostasis GO:0030104 28 15 0,000 0,06861277 0,10227028 ! cofactor transport GO:0051181 30 15 0,000 0,06861277 0,10220792 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,06861277 0,10214564 ! muscle maintenance GO:0046716 26 15 0,000 0,06861277 0,10208343 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,06861277 0,1020213 ! intestinal absorption GO:0050892 31 15 0,000 0,06861277 0,10195924 ! dopamine metabolic process GO:0042417 35 15 0,000 0,06861277 0,10189726 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,06861277 0,10183535 ! heme biosynthetic process GO:0006783 33 15 0,000 0,06861277 0,10177352 ! cell killing GO:0001906 32 15 0,000 0,06861277 0,10171177 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,06861277 0,10165008 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,06861277 0,10158848 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,06861277 0,10152695 ! actin filament polymerization GO:0030041 27 15 0,000 0,06861277 0,10146549 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,06861277 0,10140411 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,07301686 0,10784776 ! positive regulation of cell size GO:0045793 29 16 0,000 0,07301686 0,10778259 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,07301686 0,10771751 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,07301686 0,1076525 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,07301686 0,10758757 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,07301686 0,10752272 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,07301686 0,10745795 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07301686 0,10739325 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,07301686 0,10732863 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,07301686 0,1072641 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,07301686 0,10719963 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,07301686 0,10713525 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,07301686 0,10707094 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,07301686 0,10700671 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,07301686 0,10694256 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,07301686 0,10687848 ! protein polyubiquitination GO:0000209 41 16 0,000 0,07301686 0,10681449 ! glutamate metabolic process GO:0006536 25 16 0,000 0,07301686 0,10675056 ! pituitary gland development GO:0021983 30 16 0,000 0,07301686 0,10668672 ! response to osmotic stress GO:0006970 27 16 0,000 0,07301686 0,10662295 ! lysosomal transport GO:0007041 31 16 0,000 0,07301686 0,10655925 ! fructose metabolic process GO:0006000 25 16 0,000 0,07301686 0,10649564 ! L-amino acid transport GO:0015807 33 16 0,000 0,07301686 0,10643209 ! stem cell development GO:0048864 46 16 0,000 0,07301686 0,10636863 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,07301686 0,10630524 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,07301686 0,10624192 ! intermediate filament-based process GO:0045103 36 16 0,000 0,07301686 0,10617868 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,07301686 0,10611552 ! axon cargo transport GO:0008088 46 16 0,000 0,07301686 0,10605243 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,07301686 0,10598942 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,07301686 0,10592648 ! DNA replication initiation GO:0006270 28 16 0,000 0,07301686 0,10586361 ! neuron recognition GO:0008038 40 16 0,000 0,07301686 0,10580082 ! mRNA splice site selection GO:0006376 44 16 0,000 0,07301686 0,10573811 ! tissue regeneration GO:0042246 27 16 0,000 0,07301686 0,10567547 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,07301686 0,1056129 ! biomineral formation GO:0031214 22 16 0,000 0,07301686 0,10555041 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,07301686 0,10548799 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,07301686 0,10542564 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,07301686 0,10536337 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,07301686 0,10530118 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,07301686 0,10523905 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,07301686 0,105177 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,07301686 0,10511502 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,07301686 0,10505312 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,07301686 0,10499128 ! peptide hormone processing GO:0016486 27 16 0,000 0,07301686 0,10492952 ! nitrogen compound catabolic process GO:0044270 167 94 1,000 0,0732198 0,10515931 ! carbohydrate biosynthetic process GO:0016051 158 94 1,000 0,0732198 0,10509752 ! regulation of membrane potential GO:0042391 179 94 1,000 0,0732198 0,10503581 ! regulation of defense response GO:0031347 171 95 1,000 0,07456972 0,10690952 ! sex differentiation GO:0007548 171 96 1,000 0,0759276 0,10879245 ! regulation of T cell activation GO:0050863 175 96 1,000 0,0759276 0,10872868 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,07740025 0,11077259 ! metencephalon development GO:0022037 32 17 0,000 0,07740025 0,11070774 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,07740025 0,11064296 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,07740025 0,11057826 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,07740025 0,11051363 ! gene silencing by RNA GO:0031047 38 17 0,000 0,07740025 0,11044908 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,07740025 0,1103846 ! glial cell development GO:0021782 28 17 0,000 0,07740025 0,1103202 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,07740025 0,11025587 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,07740025 0,11019162 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,07740025 0,11012744 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,07740025 0,11006334 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,07740025 0,10999931 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,07740025 0,10993536 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,07740025 0,10987148 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,07740025 0,10980768 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,07740025 0,10974395 ! membrane budding GO:0006900 42 17 0,000 0,07740025 0,10968029 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,07740025 0,10961671 ! regulation of protein binding GO:0043393 33 17 0,000 0,07740025 0,1095532 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,07740025 0,10948976 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,07740025 0,1094264 ! genitalia development GO:0048806 32 17 0,000 0,07740025 0,10936311 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,07740025 0,1092999 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,07740025 0,10923675 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,07740025 0,10917368 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,07740025 0,10911069 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,07740025 0,10904776 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,07740025 0,10898491 ! steroid catabolic process GO:0006706 34 17 0,000 0,07740025 0,10892213 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,07740025 0,10885942 ! gas transport GO:0015669 26 17 0,000 0,07740025 0,10879679 ! organic cation transport GO:0015695 32 17 0,000 0,07740025 0,10873423 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,07740025 0,10867173 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,07740025 0,10860932 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,07740025 0,10854697 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,08176304 0,1145996 ! limbic system development GO:0021761 40 18 0,000 0,08176304 0,11453389 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,08176304 0,11446826 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,08176304 0,1144027 ! adult walking behavior GO:0007628 36 18 0,000 0,08176304 0,11433721 ! patterning of blood vessels GO:0001569 43 18 0,000 0,08176304 0,1142718 ! heart looping GO:0001947 34 18 0,000 0,08176304 0,11420647 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,08176304 0,1141412 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,08176304 0,11407602 ! centrosome cycle GO:0007098 26 18 0,000 0,08176304 0,11401091 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,08176304 0,11394587 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,08176304 0,11388091 ! glutamine metabolic process GO:0006541 29 18 0,000 0,08176304 0,11381602 ! response to retinoic acid GO:0032526 31 18 0,000 0,08176304 0,1137512 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,08176304 0,11368646 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,08176304 0,11362179 ! DNA integration GO:0015074 32 18 0,000 0,08176304 0,1135572 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,08176304 0,11349268 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,08176304 0,11342823 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,08176304 0,11336385 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,08176304 0,11329955 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,08176304 0,11323532 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,08176304 0,11317117 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,08176304 0,11310708 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,08176304 0,11304307 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,08176304 0,11297913 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,08176304 0,11291527 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,08176304 0,11285147 ! nerve development GO:0021675 34 18 0,000 0,08176304 0,11278775 ! defense response to virus GO:0051607 43 18 0,000 0,08176304 0,1127241 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,08176304 0,11266052 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,08176304 0,11259702 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,08610532 0,11851003 ! positive regulation of translation GO:0045727 31 19 0,000 0,08610532 0,1184433 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,08610532 0,11837664 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,08610532 0,11831007 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,08610532 0,11824356 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,08610532 0,11817713 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,08610532 0,11811078 ! memory GO:0007613 34 19 0,000 0,08610532 0,1180445 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,08610532 0,11797829 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,08610532 0,11791216 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,08610532 0,1178461 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,08610532 0,11778012 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,08610532 0,11771421 ! cerebral cortex development GO:0021987 40 19 0,000 0,08610532 0,11764838 ! pigmentation during development GO:0048066 42 19 0,000 0,08610532 0,11758261 ! response to vitamin A GO:0033189 32 19 0,000 0,08610532 0,11751693 ! heme metabolic process GO:0042168 40 19 0,000 0,08610532 0,11745131 ! neuromuscular junction development GO:0007528 43 19 0,000 0,08610532 0,11738577 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,08610532 0,1173203 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,08610532 0,1172549 ! response to fungus GO:0009620 26 19 0,000 0,08610532 0,11718958 ! peptide cross-linking GO:0018149 39 19 0,000 0,08610532 0,11712433 ! protein export from nucleus GO:0006611 40 19 0,000 0,08610532 0,11705915 ! heart process GO:0003015 32 19 0,000 0,08610532 0,11699405 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,08610532 0,11692901 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,08610532 0,11686405 ! visual learning GO:0008542 38 19 0,000 0,08610532 0,11679917 ! cellular pigmentation GO:0033059 37 19 0,000 0,08610532 0,11673435 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,08610532 0,1166696 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,08610532 0,11660493 ! vitamin transport GO:0051180 31 19 0,000 0,08610532 0,11654033 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,08610532 0,1164758 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,08610532 0,11641134 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,08610532 0,11634696 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,08610532 0,11628264 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,08610532 0,1162184 ! cilium assembly GO:0042384 38 19 0,000 0,08610532 0,11615422 ! peptide hormone secretion GO:0030072 32 19 0,000 0,08610532 0,11609012 ! protein secretion GO:0009306 45 20 0,000 0,09042719 0,12184976 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,09042719 0,12178259 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,09042719 0,12171549 ! positive regulation of ossification GO:0045778 50 20 0,000 0,09042719 0,12164847 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,09042719 0,12158152 ! skin development GO:0043588 42 20 0,000 0,09042719 0,12151464 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,09042719 0,12144784 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,09042719 0,12138111 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,09042719 0,12131445 ! response to vitamin GO:0033273 36 20 0,000 0,09042719 0,12124787 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,09042719 0,12118136 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,09042719 0,12111492 ! bile acid metabolic process GO:0008206 34 20 0,000 0,09042719 0,12104856 ! response to alkaloid GO:0043279 38 20 0,000 0,09042719 0,12098227 ! retinoid metabolic process GO:0001523 34 20 0,000 0,09042719 0,12091605 GO:0016101|diterpenoid metabolic process, ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,09042719 0,1208499 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,09042719 0,12078383 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,09042719 0,12071782 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 0,000 0,09042719 0,12065189 ! body fluid secretion GO:0007589 33 20 0,000 0,09042719 0,12058604 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,09042719 0,12052025 ! peptide secretion GO:0002790 38 20 0,000 0,09042719 0,12045453 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,09042719 0,12038889 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,09042719 0,12032332 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,09042719 0,12025782 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,09042719 0,12019239 ! cell-cell junction organization GO:0045216 43 20 0,000 0,09042719 0,12012703 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,09042719 0,12006175 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,09042719 0,11999653 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,09042719 0,11993139 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,09042719 0,11986631 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,09042719 0,11980131 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,09042719 0,11973638 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,09042719 0,11967151 ! negative regulation of translation GO:0017148 32 20 0,000 0,09042719 0,11960672 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,09042719 0,119542 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,09472874 0,12516079 ! hormone secretion GO:0046879 39 21 0,000 0,09472874 0,12509314 ! cAMP metabolic process GO:0046058 41 21 0,000 0,09472874 0,12502555 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,09472874 0,12495805 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,09472874 0,12489061 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,09472874 0,12482325 ! ovarian follicle development GO:0001541 39 21 0,000 0,09472874 0,12475596 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,09472874 0,12468874 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,09472874 0,12462159 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,09472874 0,12455452 ! plasma membrane fusion GO:0045026 33 21 0,000 0,09472874 0,12448752 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,09472874 0,12442059 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,09472874 0,12435374 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,09472874 0,12428695 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,09472874 0,12422024 ! diencephalon development GO:0021536 36 21 0,000 0,09472874 0,12415359 ! collagen fibril organization GO:0030199 62 21 0,000 0,09472874 0,12408702 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,09472874 0,12402053 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,09472874 0,1239541 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,09472874 0,12388774 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,09472874 0,12382146 ! collagen catabolic process GO:0030574 29 21 0,000 0,09472874 0,12375524 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,09472874 0,1236891 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,09472874 0,12362302 ! sperm-egg recognition GO:0035036 23 21 0,000 0,09472874 0,12355702 ! actin filament-based movement GO:0030048 47 21 0,000 0,09472874 0,12349109 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,09472874 0,12342523 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,09901006 0,12893475 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,09901006 0,12886605 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,09901006 0,12879743 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,09901006 0,12872889 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,09901006 0,12866042 ! microtubule-based transport GO:0010970 59 22 0,000 0,09901006 0,12859202 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,09901006 0,12852369 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,09901006 0,12845543 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,09901006 0,12838725 ! cellular response to starvation GO:0009267 37 22 0,000 0,09901006 0,12831914 ! vacuolar transport GO:0007034 41 22 0,000 0,09901006 0,1282511 ! central nervous system neuron development GO:0021954 47 22 0,000 0,09901006 0,12818314 ! fucose metabolic process GO:0006004 44 22 0,000 0,09901006 0,12811524 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,09901006 0,12804742 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,09901006 0,12797967 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,09901006 0,12791199 ! cell aging GO:0007569 48 22 0,000 0,09901006 0,12784439 ! stem cell differentiation GO:0048863 57 22 0,000 0,09901006 0,12777685 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,09901006 0,12770939 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,09901006 0,127642 ! cytolysis GO:0019835 27 22 0,000 0,09901006 0,12757467 ! renal system process GO:0003014 42 22 0,000 0,09901006 0,12750742 ! vasodilation GO:0042311 40 22 0,000 0,09901006 0,12744024 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,09901006 0,12737313 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,09901006 0,1273061 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,09901006 0,12723913 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,09901006 0,12717223 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,09901006 0,1271054 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,09901006 0,12703865 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,09901006 0,12697196 ! sarcomere organization GO:0045214 32 22 0,000 0,09901006 0,12690534 ! positive regulation of B cell activation GO:0050871 42 22 0,000 0,09901006 0,1268388 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,09901006 0,12677232 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,09901006 0,12670591 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,09901006 0,12663957 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,09901006 0,1265733 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,09901006 0,1265071 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,09901006 0,12644097 ! protein stabilization GO:0050821 41 22 0,000 0,09901006 0,12637491 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,10327126 0,13174501 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,10327126 0,13167625 ! gluconeogenesis GO:0006094 38 23 0,000 0,10327126 0,13160756 ! glycerol metabolic process GO:0006071 40 23 0,000 0,10327126 0,13153894 ! viral genome replication GO:0019079 44 23 0,000 0,10327126 0,1314704 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,10327126 0,13140192 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,10327126 0,13133352 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,10327126 0,13126519 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,10327126 0,13119693 ! regeneration GO:0031099 42 23 0,000 0,10327126 0,13112874 ! axis specification GO:0009798 43 23 0,000 0,10327126 0,13106062 ! visual behavior GO:0007632 46 23 0,000 0,10327126 0,13099257 ! response to ethanol GO:0045471 47 23 0,000 0,10327126 0,13092459 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,10327126 0,13085669 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,10327126 0,13078885 ! peroxisome organization GO:0007031 43 23 0,000 0,10327126 0,13072108 ! lysosome organization GO:0007040 47 23 0,000 0,10327126 0,13065339 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,10327126 0,13058576 ! vesicle targeting GO:0006903 49 23 0,000 0,10327126 0,13051821 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,10327126 0,13045072 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,10327126 0,1303833 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,10327126 0,13031596 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,10327126 0,13024868 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,10327126 0,13018147 ! DNA modification GO:0006304 36 23 0,000 0,10327126 0,13011433 ! fatty acid transport GO:0015908 47 23 0,000 0,10327126 0,13004726 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,10327126 0,12998026 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,10327126 0,12991333 ! hormone transport GO:0009914 41 23 0,000 0,10327126 0,12984647 ! cell-cell recognition GO:0009988 28 23 0,000 0,10327126 0,12977968 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,10327126 0,12971295 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,10327126 0,1296463 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,10327126 0,12957971 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,10751243 0,13483206 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,10751243 0,13476288 GO:0016444|somatic cell DNA recombination, ! positive regulation of cell adhesion GO:0045785 61 24 0,000 0,10751243 0,13469377 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,10751243 0,13462474 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,10751243 0,13455577 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,10751243 0,13448687 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,10751243 0,13441804 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,10751243 0,13434929 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,10751243 0,1342806 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,10751243 0,13421199 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,10751243 0,13414344 GO:0042278|purine nucleoside metabolic process, ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,10751243 0,13407497 ! regulation of viral reproduction GO:0050792 41 24 0,000 0,10751243 0,13400656 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,10751243 0,13393822 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,10751243 0,13386996 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,10751243 0,13380176 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,10751243 0,13373363 ! pallium development GO:0021543 56 24 0,000 0,10751243 0,13366558 ! oogenesis GO:0048477 44 24 0,000 0,10751243 0,13359759 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,10751243 0,13352967 ! platelet activation GO:0030168 41 24 0,000 0,10751243 0,13346182 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,10751243 0,13339404 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,10751243 0,13332632 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,10751243 0,13325868 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,10751243 0,1331911 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,10751243 0,1331236 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,10751243 0,13305616 ! regulation of amine transport GO:0051952 41 24 0,000 0,10751243 0,13298879 ! positive regulation of fibroblast proliferation GO:0048146 48 25 0,000 0,11173365 0,13814034 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 0,000 0,11173365 0,13807047 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,11173365 0,13800066 ! leukocyte adhesion GO:0007159 55 25 0,000 0,11173365 0,13793093 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,11173365 0,13786127 ! phototransduction GO:0007602 37 25 0,000 0,11173365 0,13779168 ! keratinization GO:0031424 37 25 0,000 0,11173365 0,13772215 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,11173365 0,1376527 ! vacuole organization GO:0007033 49 25 0,000 0,11173365 0,13758332 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,11173365 0,13751401 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,11173365 0,13744477 ! receptor metabolic process GO:0043112 53 25 0,000 0,11173365 0,1373756 ! chromosome condensation GO:0030261 48 25 0,000 0,11173365 0,13730649 ! regulation of behavior GO:0050795 48 25 0,000 0,11173365 0,13723746 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,11173365 0,1371685 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,11173365 0,1370996 ! immunoglobulin production GO:0002377 62 25 0,000 0,11173365 0,13703078 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,11173365 0,13696202 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,11173365 0,13689334 ! liver development GO:0001889 55 25 0,000 0,11173365 0,13682472 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,11593503 0,14189844 ! myelination GO:0042552 50 26 0,000 0,11593503 0,14182738 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,11593503 0,1417564 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,11593503 0,14168548 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,11593503 0,14161464 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,11593503 0,14154387 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,11593503 0,14147317 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,11593503 0,14140253 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,11593503 0,14133197 ! digestive system process GO:0022600 49 26 0,000 0,11593503 0,14126148 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,11593503 0,14119107 ! coenzyme catabolic process GO:0009109 42 26 0,000 0,11593503 0,14112072 ! negative regulation of cell development GO:0010721 83 26 0,000 0,11593503 0,14105044 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,11593503 0,14098023 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,11593503 0,14091009 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,11593503 0,14084002 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,11593503 0,14077002 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,11593503 0,14070009 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,11593503 0,14063023 GO:0045840|positive regulation of mitosis, ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,11593503 0,14056044 ! blastocyst development GO:0001824 50 26 0,000 0,11593503 0,14049071 ! telomere organization GO:0032200 46 26 0,000 0,11593503 0,14042106 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,11593503 0,14035148 ! neural tube closure GO:0001843 58 26 0,000 0,11593503 0,14028196 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,11593503 0,14021251 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,11593503 0,14014314 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,12011665 0,1451261 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,12011665 0,14505437 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,12011665 0,1449827 ! iron ion transport GO:0006826 65 27 0,000 0,12011665 0,1449111 ! superoxide metabolic process GO:0006801 41 27 0,000 0,12011665 0,14483958 ! tube lumen formation GO:0035148 59 27 0,000 0,12011665 0,14476812 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,12011665 0,14469674 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,12011665 0,14462542 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,12011665 0,14455418 ! response to starvation GO:0042594 47 27 0,000 0,12011665 0,14448301 ! response to toxin GO:0009636 49 27 0,000 0,12011665 0,1444119 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,12011665 0,14434087 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,12011665 0,1442699 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,12011665 0,14419901 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,12011665 0,14412818 ! leukocyte proliferation GO:0070661 59 27 0,000 0,12011665 0,14405743 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,12011665 0,14398674 ! regulation of fibroblast proliferation GO:0048145 56 28 0,000 0,12427862 0,14890273 ! neuron fate commitment GO:0048663 52 28 0,000 0,12427862 0,14882973 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,12427862 0,14875681 ! circadian rhythm GO:0007623 56 28 0,000 0,12427862 0,14868397 ! dendrite development GO:0016358 67 28 0,000 0,12427862 0,14861119 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,12427862 0,14853848 ! sperm motility GO:0030317 37 28 0,000 0,12427862 0,14846585 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,12427862 0,14839328 ! base-excision repair GO:0006284 41 28 0,000 0,12427862 0,14832079 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,12427862 0,14824837 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,12427862 0,14817602 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,12427862 0,14810374 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,12427862 0,14803152 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,12427862 0,14795938 ! glutathione metabolic process GO:0006749 42 28 0,000 0,12427862 0,14788731 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,12427862 0,14781532 ! lipid oxidation GO:0034440 48 28 0,000 0,12427862 0,14774339 GO:0019395|fatty acid oxidation, ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,12842101 0,15259364 ! translational initiation GO:0006413 66 29 0,000 0,12842101 0,15251946 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,12842101 0,15244535 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,12842101 0,15237131 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,12842101 0,15229734 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,12842101 0,15222345 ! primary neural tube formation GO:0014020 61 29 0,000 0,12842101 0,15214962 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,12842101 0,15207587 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,12842101 0,15200219 ! synaptogenesis GO:0007416 46 29 0,000 0,12842101 0,15192858 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,12842101 0,15185504 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,12842101 0,15178158 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,12842101 0,15170818 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,12842101 0,15163486 ! phenol metabolic process GO:0018958 56 30 0,000 0,13254392 0,15642744 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,13254392 0,15635191 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,13254392 0,15627645 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,13254392 0,15620106 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,13254392 0,15612575 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,13254392 0,15605051 ! acute-phase response GO:0006953 50 30 0,000 0,13254392 0,15597534 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,13254392 0,15590024 ! myofibril assembly GO:0030239 50 30 0,000 0,13254392 0,15582522 GO:0055002|striated muscle cell development, ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,13254392 0,15575026 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,13254392 0,15567538 ! cell fate determination GO:0001709 64 30 0,000 0,13254392 0,15560058 ! phospholipid transport GO:0015914 65 30 0,000 0,13254392 0,15552584 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,13254392 0,15545118 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,13254392 0,15537658 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,13254392 0,15530206 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,13254392 0,15522761 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,13254392 0,15515323 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 0,000 0,13254392 0,15507893 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,13664745 0,1598036 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,13664745 0,15972714 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,13664745 0,15965075 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,13664745 0,15957443 ! cell junction assembly GO:0034329 85 31 0,000 0,13664745 0,15949819 ! regulation of innate immune response GO:0045088 57 31 0,000 0,13664745 0,15942202 ! ovulation cycle process GO:0022602 55 31 0,000 0,13664745 0,15934592 ! peptide transport GO:0015833 60 31 0,000 0,13664745 0,1592699 ! male gonad development GO:0008584 56 31 0,000 0,13664745 0,15919395 ! iron ion homeostasis GO:0055072 60 31 0,000 0,13664745 0,15911807 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,13664745 0,15904226 ! detection of light stimulus GO:0009583 44 31 0,000 0,13664745 0,15896653 ! cellular response to extracellular stimulus GO:0031668 52 31 0,000 0,13664745 0,15889087 ! natural killer cell activation GO:0030101 50 31 0,000 0,13664745 0,15881528 ! ensheathment of neurons GO:0007272 64 31 0,000 0,13664745 0,15873976 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,13664745 0,15866431 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,13664745 0,15858894 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,13664745 0,15851363 ! eye morphogenesis GO:0048592 65 31 0,000 0,13664745 0,1584384 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,13664745 0,15836324 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,14073168 0,1630192 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,14073168 0,16294194 ! collagen metabolic process GO:0032963 49 32 0,000 0,14073168 0,16286475 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,14073168 0,16278763 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,14073168 0,16271059 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,14073168 0,16263363 ! muscle cell development GO:0055001 52 32 0,000 0,14073168 0,16255673 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,14073168 0,16247991 ! ovulation cycle GO:0042698 57 32 0,000 0,14073168 0,16240316 ! peripheral nervous system development GO:0007422 68 32 0,000 0,14073168 0,16232648 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,14073168 0,16224987 ! gene silencing GO:0016458 71 32 0,000 0,14073168 0,16217334 ! regulation of pH GO:0006885 56 33 0,000 0,1447967 0,16677904 ! pigment biosynthetic process GO:0046148 73 33 0,000 0,1447967 0,16670044 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,1447967 0,16662192 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,1447967 0,16654347 ! response to ionizing radiation GO:0010212 74 33 0,000 0,1447967 0,1664651 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,1447967 0,1663868 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,1447967 0,16630857 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,1447967 0,16623042 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,1447967 0,16615234 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,1447967 0,16607434 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,1447967 0,1659964 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,1447967 0,16591854 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,1488426 0,17047467 ! glial cell differentiation GO:0010001 67 34 0,000 0,1488426 0,17039479 ! post-embryonic development GO:0009791 76 34 0,000 0,1488426 0,17031498 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,1488426 0,17023524 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,1488426 0,17015558 ! spliceosome assembly GO:0000245 75 34 0,000 0,1488426 0,170076 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,1488426 0,16999649 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,1488426 0,16991705 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,15286948 0,17443258 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,15286948 0,17435114 ! negative regulation of secretion GO:0051048 68 35 0,000 0,15286948 0,17426978 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,15286948 0,1741885 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,15286948 0,17410729 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,15286948 0,17402616 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,15286948 0,17394511 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,15286948 0,17386413 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,15286948 0,17378322 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,15286948 0,17370239 ! ceramide metabolic process GO:0006672 72 35 0,000 0,15286948 0,17362164 ! telencephalon development GO:0021537 81 35 0,000 0,15286948 0,17354096 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,15286948 0,17346036 ! vesicle localization GO:0051648 70 35 0,000 0,15286948 0,17337983 ! regulation of muscle development GO:0048634 82 36 0,000 0,15687742 0,17784294 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,15687742 0,17776046 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,15687742 0,17767804 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,15687742 0,17759571 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,15687742 0,17751345 ! positive regulation of cell development GO:0010720 85 36 0,000 0,15687742 0,17743127 ! protein targeting to membrane GO:0006612 75 36 0,000 0,15687742 0,17734916 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,15687742 0,17726713 ! aerobic respiration GO:0009060 56 36 0,000 0,15687742 0,17718518 ! cytokine production GO:0001816 68 36 0,000 0,15687742 0,1771033 ! embryonic organ development GO:0048568 67 36 0,000 0,15687742 0,1770215 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,15687742 0,17693977 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,15687742 0,17685812 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,16086651 0,18127163 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,16086651 0,18118805 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,16086651 0,18110456 ! sister chromatid segregation GO:0000819 65 37 0,000 0,16086651 0,18102114 ! odontogenesis GO:0042476 74 37 0,000 0,16086651 0,18093779 ! cell junction organization GO:0034330 96 37 0,000 0,16086651 0,18085453 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,16086651 0,18077134 ! female gonad development GO:0008585 71 37 0,000 0,16086651 0,18068822 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,16086651 0,18060519 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,16086651 0,18052223 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,16483684 0,18489274 ! meiosis I GO:0007127 74 38 0,000 0,16483684 0,18480789 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,16483684 0,18472312 ! organic anion transport GO:0015711 82 38 0,000 0,16483684 0,18463842 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,16483684 0,1845538 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,16483684 0,18446926 ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,16483684 0,1843848 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,16483684 0,18430041 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,16483684 0,1842161 ! spermatid development GO:0007286 69 38 0,000 0,16483684 0,18413187 ! pigment metabolic process GO:0042440 87 38 0,000 0,16483684 0,18404771 ! neural tube formation GO:0001841 79 38 0,000 0,16483684 0,18396364 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,16878849 0,1882878 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,16878849 0,18820187 ! negative regulation of binding GO:0051100 71 39 0,000 0,16878849 0,18811601 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,16878849 0,18803023 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,16878849 0,18794452 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,16878849 0,1878589 ! positive regulation of leukocyte proliferation GO:0070665 70 39 0,000 0,16878849 0,18777335 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,16878849 0,18768789 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,17272156 0,19197396 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,17272156 0,19188666 ! learning GO:0007612 82 40 0,000 0,17272156 0,19179944 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,17272156 0,1917123 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,17272156 0,19162524 ! mismatch repair GO:0006298 58 40 0,000 0,17272156 0,19153825 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,17272156 0,19145135 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,17272156 0,19136452 ! RNA export from nucleus GO:0006405 61 41 0,000 0,17663613 0,1956129 ! mRNA catabolic process GO:0006402 79 41 0,000 0,17663613 0,19552427 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,17663613 0,19543571 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,17663613 0,19534724 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,17663613 0,19525885 ! gliogenesis GO:0042063 91 41 0,000 0,17663613 0,19517054 ! feeding behavior GO:0007631 69 41 0,000 0,17663613 0,1950823 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,17663613 0,19499415 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,17663613 0,19490608 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,17663613 0,19481808 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,17663613 0,19473017 ! spermatid differentiation GO:0048515 73 41 0,000 0,17663613 0,19464233 ! RNA modification GO:0009451 64 41 0,000 0,17663613 0,19455458 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,18053228 0,19875636 ! ear morphogenesis GO:0042471 64 42 0,000 0,18053228 0,19866683 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,18053228 0,19857738 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,18053228 0,19848801 ! regulation of protein secretion GO:0050708 77 42 0,000 0,18053228 0,19839872 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,18053228 0,19830951 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,18053228 0,19822039 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,18441011 0,20238719 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,18441011 0,20229631 ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,18441011 0,20220551 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,18441011 0,2021148 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,18441011 0,20202416 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,18441011 0,20193361 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,18441011 0,20184314 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,18441011 0,20175275 ! ion transmembrane transport GO:0034220 79 43 0,000 0,18441011 0,20166244 ! neuron migration GO:0001764 85 43 0,000 0,18441011 0,20157221 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,18441011 0,20148206 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,18826969 0,205607 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,18826969 0,20551513 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,18826969 0,20542334 ! striated muscle contraction GO:0006941 85 44 0,000 0,18826969 0,20533163 ! phagocytosis GO:0006909 105 44 0,000 0,18826969 0,20524001 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,18826969 0,20514846 ! double-strand break repair GO:0006302 85 44 0,000 0,18826969 0,205057 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,19211112 0,20914771 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,19211112 0,20905455 ! induction of apoptosis by intracellular signals GO:0008629 95 45 0,000 0,19211112 0,20896147 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,19211112 0,20886847 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! biopolymer methylation GO:0043414 91 45 0,000 0,19211112 0,20877556 ! B cell differentiation GO:0030183 124 45 0,000 0,19211112 0,20868273 ! female gamete generation GO:0007292 71 45 0,000 0,19211112 0,20858998 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,19211112 0,20849732 ! maintenance of location in cell GO:0051651 101 45 0,000 0,19211112 0,20840473 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,19593447 0,21245802 ! glycolysis GO:0006096 71 46 0,000 0,19593447 0,21236376 ! leukocyte migration GO:0050900 75 46 0,000 0,19593447 0,21226959 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,19593447 0,2121755 ! pigmentation GO:0043473 103 46 0,000 0,19593447 0,21208149 ! neural tube development GO:0021915 91 47 0,000 0,19973984 0,21610471 ! positive regulation of defense response GO:0031349 88 48 0,000 0,20352731 0,22010501 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,20352731 0,22000762 ! mitochondrial transport GO:0006839 94 48 0,000 0,20352731 0,21991031 ! cellular component disassembly GO:0022411 89 48 0,000 0,20352731 0,21981309 ! endosome transport GO:0016197 127 48 0,000 0,20352731 0,21971596 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,20352731 0,21961891 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,20352731 0,21952195 ! methylation GO:0032259 97 48 0,000 0,20352731 0,21942507 ! response to calcium ion GO:0051592 94 49 0,000 0,20729696 0,22339059 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,20729696 0,22329209 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,20729696 0,22319368 ! regulation of mast cell proliferation GO:0070666 89 49 0,000 0,20729696 0,22309536 ! regulation of action potential GO:0001508 102 50 0,000 0,21104887 0,2270332 ! regulation of ion transport GO:0043269 86 50 0,000 0,21104887 0,22693327 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,21104887 0,22683343 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,21104887 0,22673368 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,21104887 0,22663402 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,21104887 0,22653444 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,21104887 0,22643495 ! peptide metabolic process GO:0006518 80 51 0,000 0,21478313 0,23034029 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,21478313 0,23023922 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,21849982 0,23412064 ! Notch signaling pathway GO:0007219 111 52 0,000 0,21849982 0,234018 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,21849982 0,23391545 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,21849982 0,23381299 ! excretion GO:0007588 87 52 0,000 0,21849982 0,23371062 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,21849982 0,23360834 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,21849982 0,23350615 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,21849982 0,23340405 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,21849982 0,23330203 ! amino acid activation GO:0043038 98 52 0,000 0,21849982 0,23320011 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,22219902 0,23704463 ! inner ear development GO:0048839 89 53 0,000 0,22219902 0,23694116 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,22219902 0,23683778 ! regulation of leukocyte proliferation GO:0070663 97 53 0,000 0,22219902 0,2367345 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,22219902 0,2366313 ! cartilage development GO:0051216 99 53 0,000 0,22219902 0,23652819 ! synapse organization GO:0050808 102 53 0,000 0,22219902 0,23642517 ! regulation of angiogenesis GO:0045765 125 54 0,000 0,22588081 0,24023806 ! regulation of translational initiation GO:0006446 87 54 0,000 0,22588081 0,24013352 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,22588081 0,24002907 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,22588081 0,23992471 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,22588081 0,23982044 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,22588081 0,23971626 ! regulation of cell shape GO:0008360 142 54 0,000 0,22588081 0,23961217 ! RNA catabolic process GO:0006401 103 55 0,000 0,22954528 0,24339372 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,22954528 0,24328812 ! cell recognition GO:0008037 98 55 0,000 0,22954528 0,24318262 ! glucose catabolic process GO:0006007 88 56 0,000 0,23319251 0,24693944 ! RNA elongation GO:0006354 90 56 0,000 0,23319251 0,24683245 ! chloride transport GO:0006821 102 57 0,000 0,23682257 0,25056628 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,23682257 0,25045781 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,24043555 0,25416878 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,24043555 0,25405884 ! aging GO:0007568 112 58 0,000 0,24043555 0,25394901 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,24043555 0,25383926 ! nuclear export GO:0051168 110 59 0,000 0,24403153 0,25752441 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,24761058 0,26118853 ! DNA catabolic process GO:0006308 94 60 0,000 0,24761058 0,26107581 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,24761058 0,26096318 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,25117279 0,26460333 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,25117279 0,26448928 ! regulation of heart contraction GO:0008016 123 61 0,000 0,25117279 0,26437532 ! camera-type eye development GO:0043010 126 61 0,000 0,25117279 0,26426147 ! proton transport GO:0015992 117 61 0,000 0,25117279 0,26414771 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,25471823 0,26776103 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,25471823 0,26764587 ! tRNA processing GO:0008033 102 62 0,000 0,25471823 0,2675308 ! regulation of homeostatic process GO:0032844 148 62 0,000 0,25471823 0,26741583 ! regulation of mitosis GO:0007088 112 63 0,000 0,25824699 0,27100404 GO:0051783|regulation of nuclear division, ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,25824699 0,27088767 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,25824699 0,27077141 ! hydrogen transport GO:0006818 121 64 0,000 0,26175914 0,27433615 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,26175914 0,27421851 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,26175914 0,27410097 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,26525475 0,2776424 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,26525475 0,27752349 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,26525475 0,27740469 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,26525475 0,27728599 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,26525475 0,27716739 ! ear development GO:0043583 114 66 0,000 0,26873391 0,28068275 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,26873391 0,2805628 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,2721967 0,28405662 GO:0035113|embryonic appendage morphogenesis, ! chromosome segregation GO:0007059 127 67 0,000 0,2721967 0,28393533 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,2721967 0,28381414 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,2721967 0,28369306 ! secondary metabolic process GO:0019748 125 67 0,000 0,2721967 0,28357208 ! hexose catabolic process GO:0019320 113 68 0,000 0,27564319 0,2870402 ! extracellular matrix organization GO:0030198 146 68 0,000 0,27564319 0,2869179 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,27564319 0,2867957 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! adaptive immune response GO:0002250 126 68 0,000 0,27564319 0,28667361 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,27564319 0,28655162 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,27907345 0,28999423 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,27907345 0,28987093 ! single fertilization GO:0007338 83 69 0,000 0,27907345 0,28974774 ! activation of immune response GO:0002253 120 70 0,000 0,28248756 0,29316785 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,28248756 0,29304336 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,2858856 0,2964425 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,2858856 0,29631673 ! appendage morphogenesis GO:0035107 150 72 0,000 0,28926764 0,29969502 GO:0035108|limb morphogenesis, ! actin filament organization GO:0007015 167 72 0,000 0,28926764 0,29956798 ! B cell activation GO:0042113 179 72 0,000 0,28926764 0,29944104 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,28926764 0,29931421 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,28926764 0,29918749 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,28926764 0,29906088 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,28926764 0,29893437 ! appendage development GO:0048736 151 73 0,000 0,29263376 0,30228511 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,29263376 0,30215735 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,29263376 0,30202969 ! acute inflammatory response GO:0002526 118 74 0,000 0,29598404 0,30535853 ! amino acid transport GO:0006865 148 74 0,000 0,29598404 0,30522963 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,29598404 0,30510085 ! transition metal ion transport GO:0000041 143 75 0,000 0,29931854 0,30840792 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,29931854 0,3082779 ! eye development GO:0001654 155 75 0,000 0,29931854 0,30814799 ! axon guidance GO:0007411 162 75 0,000 0,29931854 0,30801819 ! rhythmic process GO:0048511 142 75 0,000 0,29931854 0,3078885 ! learning or memory GO:0007611 161 76 0,000 0,30263734 0,3111713 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,30263734 0,31104039 ! neurotransmitter transport GO:0006836 142 77 0,000 0,30594051 0,31430305 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,30594051 0,31417094 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,30594051 0,31403893 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,30594051 0,31390704 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,30922813 0,31714707 ! fertilization GO:0009566 99 78 0,000 0,30922813 0,31701398 ! blood coagulation GO:0007596 151 79 0,000 0,31250027 0,32023412 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,31250027 0,32009985 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,31250027 0,3199657 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,31250027 0,31983165 ! meiosis GO:0007126 143 81 0,000 0,31899839 0,32634551 GO:0051327|M phase of meiotic cell cycle, ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,31899839 0,3262089 ! meiotic cell cycle GO:0051321 144 82 0,000 0,32222452 0,32937009 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,32543546 0,3325131 ! exocytosis GO:0006887 153 83 0,000 0,32543546 0,33237409 ! response to drug GO:0042493 149 83 0,000 0,32543546 0,3322352 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,32543546 0,33209642 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,32543546 0,33195776 ! response to metal ion GO:0010038 158 84 0,000 0,32863128 0,33507772 ! response to nutrient GO:0007584 135 84 0,000 0,32863128 0,33493793 ! digestion GO:0007586 130 84 0,000 0,32863128 0,33479825 ! regulation of ligase activity GO:0051340 147 84 0,000 0,32863128 0,33465869 ! hemostasis GO:0007599 165 85 0,000 0,33181204 0,33775701 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,33181204 0,33761633 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,33181204 0,33747578 ! regulation of neuron differentiation GO:0045664 187 85 0,000 0,33181204 0,33733534 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,33181204 0,33719502 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,33497783 0,34027062 ! regulation of lyase activity GO:0051339 169 86 0,000 0,33497783 0,34012919 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,3381287 0,34318588 ! alcohol catabolic process GO:0046164 142 87 0,000 0,3381287 0,34304336 ! nucleosome assembly GO:0006334 126 87 0,000 0,3381287 0,34290096 ! cellular respiration GO:0045333 143 88 0,000 0,34126474 0,34593766 ! amine biosynthetic process GO:0009309 146 88 0,000 0,34126474 0,34579417 ! sensory perception of smell GO:0007608 117 88 0,000 0,34126474 0,34565081 ! chromatin assembly GO:0031497 128 88 0,000 0,34126474 0,34550756 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,34126474 0,34536444 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,344386 0,34837888 ! cellular defense response GO:0006968 123 89 0,000 0,344386 0,34823468 ! response to inorganic substance GO:0010035 173 90 0,000 0,34749256 0,35123059 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,34749256 0,35108533 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,34749256 0,35094019 ! response to unfolded protein GO:0006986 139 90 0,000 0,34749256 0,35079518 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,34749256 0,35065028 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,35058449 0,35362424 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,35058449 0,3534783 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,35366186 0,35643396 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,35672472 0,35937258 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,35672472 0,35922444 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,35672472 0,35907643 ! vitamin metabolic process GO:0006766 153 93 0,000 0,35672472 0,35892854 ! female pregnancy GO:0007565 166 94 0,000 0,35977316 0,36184678 ! sterol metabolic process GO:0016125 166 94 0,000 0,35977316 0,36169788 ! nucleosome organization GO:0034728 143 95 0,000 0,36280724 0,36459815 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,36280724 0,36444823 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,36280724 0,36429844 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,36280724 0,36414877 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,36280724 0,36399922 ! response to protein stimulus GO:0051789 158 96 0,000 0,36582703 0,36687826 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,36883259 0,36974067 ! transcription initiation GO:0006352 171 97 0,000 0,36883259 0,36958901 ! forebrain development GO:0030900 210 98 0,000 0,37182399 0,37243378 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,37182399 0,37228115 ! mRNA transport GO:0051028 185 100 0,000 0,37776457 0,37807409 ! positive regulation of immune response GO:0050778 175 100 0,000 0,37776457 0,37791927 ! hormone metabolic process GO:0042445 171 100 0,000 0,37776457 0,37776457