pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1154-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! nuclear migration GO:0007097 10 5 3,000 4,074E-09 9,371E-06 ! regulation of lipid kinase activity GO:0043550 12 7 3,000 2,828E-08 3,253E-05 ! establishment of nucleus localization GO:0040023 13 7 3,000 2,828E-08 2,168E-05 ! cellular response to extracellular stimulus GO:0031668 32 21 4,000 8,093E-08 4,654E-05 ! nucleus localization GO:0051647 15 9 3,000 1,01E-07 4,645E-05 ! cellular response to starvation GO:0009267 21 14 3,000 7,856E-07 3,012E-04 ! protein oligomerization GO:0051259 100 65 5,000 1,4E-06 4,601E-04 ! autophagic vacuole formation GO:0000045 8 5 2,000 1,542E-06 4,434E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 1,542E-06 3,942E-04 GO:0031272|regulation of pseudopodium assembly, ! cellular response to nutrient levels GO:0031669 27 18 3,000 2,362E-06 5,432E-04 ! response to starvation GO:0042594 30 19 3,000 2,979E-06 6,23E-04 ! macroautophagy GO:0016236 10 6 2,000 3,073E-06 5,889E-04 ! macrophage differentiation GO:0030225 10 6 2,000 3,073E-06 5,436E-04 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 3,484E-06 5,723E-04 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 6,796E-06 1,042E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 5,000 7,273E-06 1,046E-03 ! interphase GO:0051325 159 88 5,000 8,311E-06 1,124E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 8,536E-06 1,091E-03 ! leukocyte differentiation GO:0002521 143 90 5,000 9,466E-06 1,146E-03 ! regulation of lipid metabolic process GO:0019216 84 56 4,000 1,307E-05 1,504E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 3,000 1,516E-05 1,66E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 1,815E-05 1,897E-03 ! detection of bacterium GO:0016045 10 10 2,000 1,815E-05 1,815E-03 ! filopodium assembly GO:0046847 19 11 2,000 2,485E-05 2,382E-03 ! cell cycle checkpoint GO:0000075 108 64 4,000 2,522E-05 2,32E-03 ! auditory receptor cell differentiation GO:0042491 25 12 2,000 3,301E-05 2,92E-03 ! microspike assembly GO:0030035 23 12 2,000 3,301E-05 2,812E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 6,437E-05 5,288E-03 ! G1 phase GO:0051318 27 16 2,000 8,27E-05 6,559E-03 ! detection of biotic stimulus GO:0009595 19 16 2,000 8,27E-05 6,341E-03 ! inner ear receptor cell differentiation GO:0060113 30 16 2,000 8,27E-05 6,136E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 9,917E-05 7,128E-03 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 2,000 1E-04 6,972E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 1E-04 6,767E-03 ! response to UV GO:0009411 75 46 3,000 1,121E-04 7,367E-03 ! mechanoreceptor differentiation GO:0042490 32 18 2,000 1,196E-04 7,639E-03 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 3,000 1,22E-04 7,586E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 1,326E-04 8,024E-03 ! RNA elongation GO:0006354 62 49 3,000 1,438E-04 8,478E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,657E-04 9,529E-03 ! establishment of organelle localization GO:0051656 85 52 3,000 1,814E-04 0,01017734 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 1,926E-04 0,01054637 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 1,926E-04 0,01030111 ! autophagy GO:0006914 28 21 2,000 1,926E-04 0,01006699 ! regulation of protein complex assembly GO:0043254 81 54 3,000 2,102E-04 0,01074254 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 2,221E-04 0,01110587 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 2,221E-04 0,01086958 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 2,221E-04 0,01064313 ! protein tetramerization GO:0051262 39 22 2,000 2,221E-04 0,01042592 ! DNA damage response, signal transduction GO:0042770 96 56 3,000 2,421E-04 0,0111359 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 2,544E-04 0,01147434 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 2,544E-04 0,01125368 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 2,891E-04 0,01254638 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 2,891E-04 0,01231404 ! positive regulation of glycolysis GO:0045821 11 5 1,000 2,891E-04 0,01209015 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 2,891E-04 0,01187425 ! valine metabolic process GO:0006573 8 5 1,000 2,891E-04 0,01166593 ! regulation of centrosome cycle GO:0046605 7 5 1,000 2,891E-04 0,0114648 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 2,891E-04 0,01127048 GO:0045686|negative regulation of glial cell differentiation, ! negative regulation of T cell mediated immunity GO:0002710 11 5 1,000 2,891E-04 0,01108264 GO:0002707|negative regulation of lymphocyte mediated immunity, ! regulation of respiratory burst GO:0060263 8 5 1,000 2,891E-04 0,01090095 ! glial cell migration GO:0008347 10 5 1,000 2,891E-04 0,01072513 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 2,896E-04 0,01057399 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 2,896E-04 0,01040877 ! negative regulation of cell development GO:0010721 56 24 2,000 2,896E-04 0,01024864 GO:0050768|negative regulation of neurogenesis, ! activation of MAPK activity GO:0000187 84 59 3,000 2,963E-04 0,01032462 ! lung development GO:0030324 94 59 3,000 2,963E-04 0,01017052 ! myeloid cell differentiation GO:0030099 85 59 3,000 2,963E-04 0,01002095 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 3,278E-04 0,01092793 ! negative regulation of cell growth GO:0030308 106 62 3,000 3,587E-04 0,0117843 ! respiratory tube development GO:0030323 99 62 3,000 3,587E-04 0,01161833 ! organelle localization GO:0051640 96 62 3,000 3,587E-04 0,01145696 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 3,691E-04 0,01163055 ! negative regulation of cell size GO:0045792 108 64 3,000 4,051E-04 0,01259187 ! respiratory system development GO:0060541 100 64 3,000 4,051E-04 0,01242398 ! positive regulation of protein ubiquitination GO:0031398 8 6 1,000 4,321E-04 0,01307768 ! positive regulation of DNA repair GO:0045739 7 6 1,000 4,321E-04 0,01290784 ! regulation of helicase activity GO:0051095 11 6 1,000 4,321E-04 0,01274236 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 4,321E-04 0,01258106 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 4,321E-04 0,0124238 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 1,000 4,321E-04 0,01227042 ! ER overload response GO:0006983 7 6 1,000 4,321E-04 0,01212078 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 4,321E-04 0,01197474 ! male sex determination GO:0030238 9 6 1,000 4,321E-04 0,01183219 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 4,321E-04 0,01169299 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 4,321E-04 0,01155702 ! nucleoside catabolic process GO:0009164 6 6 1,000 4,321E-04 0,01142418 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 4,321E-04 0,01129436 ! axonal fasciculation GO:0007413 9 6 1,000 4,321E-04 0,01116746 ! positive regulation of T cell differentiation GO:0045582 39 28 2,000 4,615E-04 0,01179325 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 3,000 5,703E-04 0,01441396 ! steroid biosynthetic process GO:0006694 94 71 3,000 6,018E-04 0,01504609 ! lymphocyte differentiation GO:0030098 113 71 3,000 6,018E-04 0,01488431 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 6,028E-04 0,0147504 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 6,028E-04 0,01459513 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 6,028E-04 0,0144431 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 1,000 6,028E-04 0,0142942 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! protein heterooligomerization GO:0051291 10 7 1,000 6,028E-04 0,01414834 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 6,028E-04 0,01400543 ! B cell lineage commitment GO:0002326 17 7 1,000 6,028E-04 0,01386538 ! mast cell activation GO:0045576 9 7 1,000 6,028E-04 0,0137281 ! T cell lineage commitment GO:0002360 12 7 1,000 6,028E-04 0,01359351 ! response to tumor cell GO:0002347 12 7 1,000 6,028E-04 0,01346153 ! neuroblast proliferation GO:0007405 13 7 1,000 6,028E-04 0,01333209 ! lymph node development GO:0048535 9 7 1,000 6,028E-04 0,01320512 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 1,000 6,028E-04 0,01308055 ! DNA damage checkpoint GO:0000077 53 31 2,000 6,258E-04 0,013451 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 2,000 6,878E-04 0,01464736 ! protein import into nucleus GO:0006606 118 74 3,000 7,039E-04 0,01485345 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 7,039E-04 0,01471842 ! positive regulation of lymphocyte activation GO:0051251 108 74 3,000 7,039E-04 0,01458582 ! negative regulation of growth GO:0045926 123 75 3,000 7,405E-04 0,01520698 ! nuclear import GO:0051170 121 75 3,000 7,405E-04 0,0150724 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 7,536E-04 0,01520422 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 7,536E-04 0,01507201 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 8,009E-04 0,0158808 ! axon extension GO:0048675 11 8 1,000 8,009E-04 0,01574507 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 8,009E-04 0,01561164 ! succinate metabolic process GO:0006105 14 8 1,000 8,009E-04 0,01548045 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 1,000 8,009E-04 0,01535144 ! regulation of gliogenesis GO:0014013 20 8 1,000 8,009E-04 0,01522457 GO:0045685|regulation of glial cell differentiation, ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 8,009E-04 0,01509978 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 8,009E-04 0,01497702 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 8,009E-04 0,01485623 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 1,000 8,009E-04 0,01473738 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 8,009E-04 0,01462042 ! regulation of embryonic development GO:0045995 16 8 1,000 8,009E-04 0,0145053 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 8,233E-04 0,01479347 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 8,233E-04 0,01467879 ! DNA integrity checkpoint GO:0031570 57 34 2,000 8,233E-04 0,01456588 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 8,233E-04 0,01445469 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 8,969E-04 0,01562853 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 2,000 8,969E-04 0,01551102 ! protein localization in nucleus GO:0034504 133 80 3,000 9,439E-04 0,01620076 ! positive regulation of cell activation GO:0050867 120 81 3,000 9,888E-04 0,01684637 GO:0002696|positive regulation of leukocyte activation, ! regulation of developmental growth GO:0048638 13 9 1,000 1,026E-03 0,01735388 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,026E-03 0,01722721 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 1,026E-03 0,01710237 GO:0010469|regulation of receptor activity, ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 1,026E-03 0,01697934 ! regulation of glycolysis GO:0006110 15 9 1,000 1,026E-03 0,01685805 ! endoderm development GO:0007492 12 9 1,000 1,026E-03 0,01673849 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,026E-03 0,01662062 GO:0006600|creatine metabolic process, ! postreplication repair GO:0006301 11 9 1,000 1,026E-03 0,01650439 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 1,000 1,026E-03 0,01638978 GO:0002820|negative regulation of adaptive immune response, ! localization within membrane GO:0051668 15 9 1,000 1,026E-03 0,01627674 ! transcription initiation GO:0006352 118 85 3,000 1,184E-03 0,0186469 ! cell cycle arrest GO:0007050 150 86 3,000 1,236E-03 0,01934344 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,278E-03 0,01986301 ! hippocampus development GO:0021766 19 10 1,000 1,278E-03 0,0197297 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 1,278E-03 0,01959817 ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 1,278E-03 0,01946838 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,278E-03 0,0193403 ! response to X-ray GO:0010165 16 10 1,000 1,278E-03 0,01921389 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 1,278E-03 0,01908912 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,278E-03 0,01896597 GO:0043470|regulation of carbohydrate catabolic process, ! negative regulation of immune effector process GO:0002698 16 10 1,000 1,278E-03 0,01884439 ! inner ear development GO:0048839 57 40 2,000 1,328E-03 0,01944984 ! T cell differentiation GO:0030217 65 40 2,000 1,328E-03 0,01932674 ! double-strand break repair GO:0006302 67 40 2,000 1,328E-03 0,01920519 ! B cell differentiation GO:0030183 62 40 2,000 1,328E-03 0,01908516 ! regulation of T cell differentiation GO:0045580 59 41 2,000 1,427E-03 0,02038386 ! virus-host interaction GO:0019048 17 11 1,000 1,557E-03 0,02210058 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,557E-03 0,021965 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 1,557E-03 0,02183106 GO:0000725|recombinational repair, ! regulation of intracellular pH GO:0051453 17 11 1,000 1,557E-03 0,02169875 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 1,557E-03 0,02156804 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 1,639E-03 0,02257268 ! vesicle organization GO:0016050 79 43 2,000 1,639E-03 0,02243832 ! response to insulin stimulus GO:0032868 63 43 2,000 1,639E-03 0,02230555 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 1,651E-03 0,02234287 ! regulation of cell projection organization GO:0031344 83 44 2,000 1,752E-03 0,02356513 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 1,752E-03 0,02342813 ! regulation of cellular component biogenesis GO:0044087 158 96 3,000 1,856E-03 0,02467295 ! response to light stimulus GO:0009416 153 96 3,000 1,856E-03 0,02453115 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 1,861E-03 0,02446383 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,861E-03 0,02432483 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,861E-03 0,0241874 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,861E-03 0,02405152 ! response to gamma radiation GO:0010332 20 12 1,000 1,861E-03 0,02391715 ! positive regulation of cell cycle GO:0045787 77 45 2,000 1,87E-03 0,02389212 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 1,87E-03 0,02376012 ! protein import GO:0017038 156 99 3,000 2,077E-03 0,02624974 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 2,12E-03 0,02664452 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! protein localization in organelle GO:0033365 161 100 3,000 2,155E-03 0,02693507 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 2,192E-03 0,02725238 ! regulation of DNA repair GO:0006282 15 13 1,000 2,192E-03 0,02710587 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 2,192E-03 0,02696092 ! regulation of cellular pH GO:0030641 20 13 1,000 2,192E-03 0,02681751 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 2,192E-03 0,02667561 ! regulation of RNA stability GO:0043487 28 13 1,000 2,192E-03 0,02653522 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 2,252E-03 0,02712399 ! ear development GO:0043583 72 50 2,000 2,533E-03 0,03033862 ! negative regulation of cytoskeleton organization GO:0051494 84 50 2,000 2,533E-03 0,03018142 ! positive regulation of growth GO:0045927 67 50 2,000 2,533E-03 0,03002585 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 2,548E-03 0,03005745 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 2,548E-03 0,0299041 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 2,548E-03 0,0297523 ! limbic system development GO:0021761 25 14 1,000 2,548E-03 0,02960203 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 1,000 2,548E-03 0,02945328 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 2,548E-03 0,02930601 ! G1/S transition checkpoint GO:0031575 33 14 1,000 2,548E-03 0,02916021 ! negative regulation of inflammatory response GO:0050728 16 14 1,000 2,548E-03 0,02901586 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 2,548E-03 0,02887292 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 2,68E-03 0,03022012 ! positive regulation of cell migration GO:0030335 92 51 2,000 2,68E-03 0,0300727 ! regulation of protein ubiquitination GO:0031396 19 15 1,000 2,93E-03 0,03271386 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 2,93E-03 0,03255582 ! lipid phosphorylation GO:0046834 23 15 1,000 2,93E-03 0,0323993 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 2,93E-03 0,03224428 ! centrosome cycle GO:0007098 16 15 1,000 2,93E-03 0,03209074 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 1,000 2,93E-03 0,03193865 ! regulation of T cell mediated immunity GO:0002709 26 15 1,000 2,93E-03 0,031788 ! neuron recognition GO:0008038 22 15 1,000 2,93E-03 0,03163876 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 2,93E-03 0,03149091 ! cell projection assembly GO:0030031 76 53 2,000 2,992E-03 0,03200391 ! detection of external stimulus GO:0009581 66 54 2,000 3,155E-03 0,03359796 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 3,337E-03 0,03536684 ! protein amino acid acetylation GO:0006473 28 16 1,000 3,337E-03 0,0352046 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 1,000 3,337E-03 0,03504385 ! negative regulation of immune response GO:0050777 28 16 1,000 3,337E-03 0,03488456 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 3,337E-03 0,03472671 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 3,337E-03 0,03457029 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 3,499E-03 0,03608592 ! positive regulation of cell motion GO:0051272 99 56 2,000 3,499E-03 0,03592482 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 3,679E-03 0,03760486 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 3,679E-03 0,03743847 ! negative regulation of defense response GO:0031348 19 17 1,000 3,768E-03 0,03818153 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 3,768E-03 0,03801407 ! sensory perception of pain GO:0019233 23 17 1,000 3,768E-03 0,03784807 ! negative regulation of kinase activity GO:0033673 100 58 2,000 3,864E-03 0,03864267 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 3,864E-03 0,03847539 ! positive regulation of DNA replication GO:0045740 29 18 1,000 4,224E-03 0,04188032 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 4,224E-03 0,04170058 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 1,000 4,224E-03 0,04152237 ! somitogenesis GO:0001756 24 18 1,000 4,224E-03 0,04134568 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 4,224E-03 0,04117049 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 4,224E-03 0,04099677 ! homeostasis of number of cells GO:0048872 84 61 2,000 4,455E-03 0,04304992 ! negative regulation of transferase activity GO:0051348 105 61 2,000 4,455E-03 0,04286979 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 4,705E-03 0,04508772 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 4,705E-03 0,04490064 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 4,705E-03 0,0447151 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 4,705E-03 0,04453109 ! sex determination GO:0007530 29 19 1,000 4,705E-03 0,04434858 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 4,705E-03 0,04416757 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 4,705E-03 0,04398802 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 4,705E-03 0,04380994 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 1,000 4,705E-03 0,04363328 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 4,877E-03 0,0450494 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 4,877E-03 0,0448692 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 5,209E-03 0,04773323 ! pallium development GO:0021543 38 20 1,000 5,209E-03 0,04754381 ! DNA modification GO:0006304 28 20 1,000 5,209E-03 0,04735589 ! positive regulation of B cell activation GO:0050871 31 20 1,000 5,209E-03 0,04716945 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 1,000 5,209E-03 0,04698448 ! regulation of caspase activity GO:0043281 97 65 2,000 5,323E-03 0,04782245 ! B cell activation GO:0042113 104 65 2,000 5,323E-03 0,04763637 ! positive regulation of T cell activation GO:0050870 94 65 2,000 5,323E-03 0,04745174 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 5,737E-03 0,05094818 ! regulation of cell killing GO:0031341 34 21 1,000 5,737E-03 0,05075222 ! protein amino acid acylation GO:0043543 37 21 1,000 5,737E-03 0,05055777 ! regulation of DNA recombination GO:0000018 40 21 1,000 5,737E-03 0,0503648 ! deoxyribonucleotide metabolic process GO:0009262 27 21 1,000 5,737E-03 0,0501733 ! purine ribonucleoside metabolic process GO:0046128 28 21 1,000 5,737E-03 0,04998325 GO:0042278|purine nucleoside metabolic process, ! cell aging GO:0007569 32 21 1,000 5,737E-03 0,04979463 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 5,737E-03 0,04960743 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 5,737E-03 0,04942164 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 1,000 5,737E-03 0,04923723 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 1,000 5,737E-03 0,04905419 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 5,792E-03 0,04934232 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 6,289E-03 0,05337287 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 6,289E-03 0,05317665 ! microtubule organizing center organization GO:0031023 28 22 1,000 6,289E-03 0,05298186 GO:0051297|centrosome organization, ! barbed-end actin filament capping GO:0051016 33 22 1,000 6,289E-03 0,0527885 GO:0051693|actin filament capping, ! positive regulation of phosphorylation GO:0042327 102 70 2,000 6,542E-03 0,05471389 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 6,863E-03 0,05719509 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 6,863E-03 0,05698861 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 6,863E-03 0,05678361 ! negative regulation of DNA replication GO:0008156 35 23 1,000 6,863E-03 0,05658009 ! interaction with host GO:0051701 37 23 1,000 6,863E-03 0,05637801 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 6,863E-03 0,05617738 ! liver development GO:0001889 40 23 1,000 6,863E-03 0,05597817 ! regulation of peptidase activity GO:0052547 106 72 2,000 7,072E-03 0,057477 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 2,000 7,072E-03 0,05727462 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 2,000 7,072E-03 0,05707366 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 7,461E-03 0,06000126 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 1,000 7,461E-03 0,0597922 ! mitochondrial membrane organization GO:0007006 39 24 1,000 7,461E-03 0,05958459 ! regulation of alpha-beta T cell activation GO:0046634 35 24 1,000 7,461E-03 0,05937841 ! base-excision repair GO:0006284 31 24 1,000 7,461E-03 0,05917366 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 7,461E-03 0,05897031 ! negative regulation of actin filament depolymerization GO:0030835 36 25 1,000 8,081E-03 0,0636541 ! negative regulation of actin filament polymerization GO:0030837 36 25 1,000 8,081E-03 0,06343685 ! protein amino acid alkylation GO:0008213 39 25 1,000 8,081E-03 0,06322108 GO:0006479|protein amino acid methylation, ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 8,081E-03 0,06300677 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 8,081E-03 0,06279391 ! positive regulation of nuclear division GO:0051785 39 25 1,000 8,081E-03 0,06258249 GO:0045840|positive regulation of mitosis, ! regulation of pH GO:0006885 36 26 1,000 8,724E-03 0,06733276 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 8,724E-03 0,06710757 ! negative regulation of protein polymerization GO:0032272 38 26 1,000 8,724E-03 0,06688387 ! positive regulation of protein modification process GO:0031401 107 78 2,000 8,813E-03 0,06734202 ! T cell activation GO:0042110 134 79 2,000 9,125E-03 0,06949779 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 9,389E-03 0,07126819 ! respiratory gaseous exchange GO:0007585 47 27 1,000 9,389E-03 0,07103376 ! response to ionizing radiation GO:0010212 47 27 1,000 9,389E-03 0,07080086 ! regulation of cell cycle process GO:0010564 122 81 2,000 9,769E-03 0,07342957 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01007553 0,07548441 ! negative regulation of response to external stimulus GO:0032102 37 28 1,000 0,01007553 0,07523933 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01007553 0,07499584 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 1,000 0,01007553 0,07475392 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01007553 0,07451355 ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,01007553 0,07427473 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01007553 0,07403743 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01007553 0,07380164 ! detection of stimulus GO:0051606 108 82 2,000 0,010101 0,07375333 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,01078385 0,07849008 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,01078389 0,0782427 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01078389 0,07799666 ! telencephalon development GO:0021537 52 29 1,000 0,01078389 0,07775215 ! Golgi vesicle transport GO:0048193 138 85 2,000 0,01113508 0,08003339 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,01113508 0,07978407 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01151363 0,08224023 ! segmentation GO:0035282 41 31 1,000 0,01226452 0,08733249 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,01226452 0,08706295 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,0126058 0,08921025 ! regulation of T cell activation GO:0050863 128 89 2,000 0,0126058 0,0889366 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,0130363 0,09169264 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,0130363 0,09141309 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,0130363 0,09113524 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,0130363 0,09085907 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,0130363 0,09058457 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,01382873 0,09580147 GO:0042593|glucose homeostasis, ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01382873 0,09551378 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 1,000 0,01382873 0,09522781 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,01418269 0,09737367 ! mRNA catabolic process GO:0006402 48 34 1,000 0,01464157 0,10022506 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,01464157 0,09992766 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,01464157 0,09963201 ! neuron migration GO:0001764 46 34 1,000 0,01464157 0,09933811 ! in utero embryonic development GO:0001701 147 96 2,000 0,01543563 0,10441751 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,01547458 0,10437402 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01632752 0,10980496 GO:0090047|positive regulation of transcription regulator activity, ! cellular amide metabolic process GO:0043603 52 36 1,000 0,01632752 0,10948483 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,01720015 0,115001 ! ribonucleoside metabolic process GO:0009119 48 37 1,000 0,01720015 0,11466767 ! gliogenesis GO:0042063 71 38 1,000 0,01809224 0,12026633 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,01809224 0,11991974 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,01809224 0,11957514 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,01900355 0,12523832 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 0,01900355 0,12488049 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,01900355 0,12452471 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 1,000 0,01900355 0,12417095 ! cell growth GO:0016049 61 39 1,000 0,01900355 0,12381919 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,01993386 0,1295138 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,01993386 0,12914897 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,01993386 0,1287862 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,01993386 0,12842545 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,02088294 0,13416414 ! regulation of leukocyte mediated immunity GO:0002703 62 41 1,000 0,02088294 0,13379042 ! biopolymer methylation GO:0043414 62 41 1,000 0,02088294 0,13341878 ! mitochondrial transport GO:0006839 60 42 1,000 0,02185056 0,13921407 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,02185056 0,1388295 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,02185056 0,13844705 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,02185056 0,1380667 ! positive regulation of binding GO:0051099 59 43 1,000 0,02283649 0,14390115 ! activation of caspase activity GO:0006919 65 43 1,000 0,02283649 0,14350798 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 1,000 0,02283649 0,14311695 ! methylation GO:0032259 64 43 1,000 0,02283649 0,14272805 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,02384051 0,14859938 ! RNA catabolic process GO:0006401 64 45 1,000 0,0248624 0,15455007 ! cell recognition GO:0008037 58 45 1,000 0,0248624 0,15413349 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,02590195 0,16014644 ! histone modification GO:0016570 68 46 1,000 0,02590195 0,15971709 ! regulation of adaptive immune response GO:0002819 72 46 1,000 0,02590195 0,15929004 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02688015 0,16486489 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02688015 0,16442642 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02688015 0,16399028 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02688015 0,16355644 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02688015 0,16312489 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02688015 0,16269562 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02688015 0,16226859 ! sleep GO:0030431 11 5 0,000 0,02688015 0,16184381 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02688015 0,16142124 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02688015 0,16100087 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02688015 0,16058269 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02688015 0,16016667 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02688015 0,1597528 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02688015 0,15934107 ! tongue development GO:0043586 6 5 0,000 0,02688015 0,15893145 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02688015 0,15852394 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02688015 0,1581185 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02688015 0,15771514 ! cobalt ion transport GO:0006824 9 5 0,000 0,02688015 0,15731383 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02688015 0,15691455 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02688015 0,1565173 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02688015 0,15612206 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02688015 0,1557288 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02688015 0,15533752 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02688015 0,15494821 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02688015 0,15456084 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02688015 0,1541754 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02688015 0,15379188 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02688015 0,15341026 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02688015 0,15303053 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02688015 0,15265268 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02688015 0,15227669 ! malate metabolic process GO:0006108 7 5 0,000 0,02688015 0,15190254 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02688015 0,15153023 ! behavioral response to pain GO:0048266 7 5 0,000 0,02688015 0,15115974 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02688015 0,15079106 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02688015 0,15042417 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02688015 0,15005906 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02688015 0,14969573 ! mating behavior GO:0007617 6 5 0,000 0,02688015 0,14933414 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02688015 0,1489743 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02688015 0,14861619 ! rhythmic behavior GO:0007622 12 5 0,000 0,02688015 0,1482598 ! copulation GO:0007620 7 5 0,000 0,02688015 0,14790511 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02688015 0,14755211 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02688015 0,1472008 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02688015 0,14685115 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02688015 0,14650316 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02688015 0,14615682 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02688015 0,14581211 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02688015 0,14546902 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02688015 0,14512755 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02688015 0,14478767 ! response to protozoan GO:0001562 9 5 0,000 0,02688015 0,14444938 ! lymph vessel development GO:0001945 7 5 0,000 0,02688015 0,14411267 ! endochondral ossification GO:0001958 12 5 0,000 0,02688015 0,14377752 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02688015 0,14344393 ! parathyroid gland development GO:0060017 8 5 0,000 0,02688015 0,14311189 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02688015 0,14278137 ! anagen GO:0042640 6 5 0,000 0,02688015 0,14245238 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02688015 0,14212491 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02688015 0,14179893 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02688015 0,14147445 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02688015 0,14115145 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02688015 0,14082992 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02688015 0,14050985 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02688015 0,14019124 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02688015 0,13987406 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02688015 0,13955832 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02688015 0,139244 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02688015 0,13893109 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02688015 0,13861958 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02688015 0,13830947 ! ovulation GO:0030728 6 5 0,000 0,02688015 0,13800075 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02688015 0,1376934 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02688015 0,13738741 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,02688015 0,13708278 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02688015 0,1367795 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02688015 0,13647756 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02688015 0,13617695 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02688015 0,13587766 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02688015 0,13557968 ! polyol catabolic process GO:0046174 7 5 0,000 0,02688015 0,13528301 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02688015 0,13498763 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02688015 0,13469354 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02688015 0,13440073 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02688015 0,13410919 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02688015 0,13381891 ! urea metabolic process GO:0019627 6 5 0,000 0,02688015 0,13352988 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02688015 0,1332421 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02688015 0,13295556 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02688015 0,13267025 ! neutrophil activation GO:0042119 5 5 0,000 0,02688015 0,13238616 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02688015 0,13210328 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02688015 0,13182161 ! response to food GO:0032094 5 5 0,000 0,02688015 0,13154114 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02688015 0,13126186 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02688015 0,13098376 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02688015 0,13070684 ! forebrain neuron development GO:0021884 7 5 0,000 0,02688015 0,13043109 ! melanosome organization GO:0032438 7 5 0,000 0,02688015 0,13015649 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02688015 0,12988306 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02688015 0,12961076 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02688015 0,12933961 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02688015 0,12906959 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02688015 0,1288007 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02688015 0,12853292 ! nucleoside transport GO:0015858 6 5 0,000 0,02688015 0,12826625 ! nucleoside salvage GO:0043174 7 5 0,000 0,02688015 0,12800069 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02688015 0,12773623 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02688015 0,12747285 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02688015 0,12721057 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02688015 0,12694935 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02688015 0,12668921 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02688015 0,12643013 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02688015 0,12617211 ! depyrimidination GO:0045008 8 5 0,000 0,02688015 0,12591514 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02688015 0,12565922 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02688015 0,12540433 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02688015 0,12515048 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02688015 0,12489765 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02688015 0,12464584 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02688015 0,12439504 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02688015 0,12414525 ! monocyte differentiation GO:0030224 8 5 0,000 0,02688015 0,12389646 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02688015 0,12364867 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02688015 0,12340187 ! centrosome duplication GO:0051298 5 5 0,000 0,02688015 0,12315605 ! response to UV-C GO:0010225 6 5 0,000 0,02688015 0,1229112 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02688015 0,12266733 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02688015 0,12242443 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02688015 0,12218248 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02688015 0,12194149 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02688015 0,12170145 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02688015 0,12146235 ! melanosome transport GO:0032402 8 5 0,000 0,02688015 0,12122419 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02688015 0,12098696 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02688015 0,12075065 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02688015 0,12051527 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02688015 0,12028081 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02688015 0,12004725 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02688015 0,1198146 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02688015 0,11958285 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02688015 0,119352 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02688015 0,11912203 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02688015 0,11889295 ! neural tube patterning GO:0021532 6 5 0,000 0,02688015 0,11866475 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02688015 0,11843742 ! histone demethylation GO:0016577 9 5 0,000 0,02688015 0,11821096 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02688015 0,11798537 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02688015 0,11776064 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02688015 0,11753676 ! enteric nervous system development GO:0048484 8 5 0,000 0,02688015 0,11731373 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02688015 0,11709154 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02688015 0,1168702 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02688015 0,11664969 ! transcription termination GO:0006353 8 5 0,000 0,02688015 0,11643001 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02688015 0,11621116 ! plasminogen activation GO:0031639 5 5 0,000 0,02688015 0,11599312 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02688015 0,11577591 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02688015 0,1155595 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02688015 0,11534391 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02688015 0,11512911 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02688015 0,11491512 ! apical protein localization GO:0045176 6 5 0,000 0,02688015 0,11470192 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02688015 0,11448951 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02688015 0,11427788 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02688015 0,11406704 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02688015 0,11385697 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02688015 0,11364767 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02688015 0,11343915 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02688015 0,11323138 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02688015 0,11302438 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02688015 0,11281813 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02688015 0,11261263 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02688015 0,11240788 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02688015 0,11220387 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02688015 0,11200061 ! neural plate development GO:0001840 6 5 0,000 0,02688015 0,11179807 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02688015 0,11159627 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02688015 0,1113952 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02688015 0,11119485 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02688015 0,11099521 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02688015 0,1107963 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02688015 0,11059809 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02688015 0,1104006 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02688015 0,11020381 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02688015 0,11000771 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02688015 0,10981232 ! spindle assembly GO:0051225 5 5 0,000 0,02688015 0,10961761 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02688015 0,1094236 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02688015 0,10923027 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02688015 0,10903763 ! organ regeneration GO:0031100 7 5 0,000 0,02688015 0,10884566 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02688015 0,10865437 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02688015 0,10846375 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02688015 0,10827379 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02688015 0,1080845 GO:0055081|anion homeostasis, ! response to estrogen stimulus GO:0043627 74 47 1,000 0,02695892 0,10821208 ! covalent chromatin modification GO:0016569 75 47 1,000 0,02695892 0,10802355 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,02695892 0,10783569 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,02695892 0,10764847 ! regulation of protein polymerization GO:0032271 71 47 1,000 0,02695892 0,10746191 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,02803312 0,11155046 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 1,000 0,02803312 0,1113578 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,02803312 0,1111658 ! heart morphogenesis GO:0003007 65 48 1,000 0,02803312 0,11097447 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,02803312 0,11078379 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,02912431 0,11489866 ! heterocycle catabolic process GO:0046700 72 49 1,000 0,02912431 0,11470191 ! regulation of actin filament length GO:0030832 72 50 1,000 0,0302323 0,11886203 ! lipid modification GO:0030258 73 50 1,000 0,0302323 0,1186592 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,0302323 0,11845705 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,03135687 0,12265441 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,03135687 0,12244617 ! tRNA transcription GO:0009304 11 6 0,000 0,03216975 0,12540749 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03216975 0,1251953 GO:0045346|regulation of MHC class II biosynthetic process, ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03216975 0,12498382 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03216975 0,12477305 GO:0030816|positive regulation of cAMP metabolic process, ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03216975 0,124563 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03216975 0,12435365 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03216975 0,124145 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03216975 0,12393705 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03216975 0,1237298 ! prostate gland development GO:0030850 9 6 0,000 0,03216975 0,12352324 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03216975 0,12331737 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03216975 0,12311218 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03216975 0,12290768 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03216975 0,12270385 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03216975 0,1225007 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03216975 0,12229822 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03216975 0,1220964 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03216975 0,12189526 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03216975 0,12169477 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,03216975 0,12149494 ! neuron adhesion GO:0007158 9 6 0,000 0,03216975 0,12129577 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03216975 0,12109725 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03216975 0,12089938 ! signal peptide processing GO:0006465 8 6 0,000 0,03216975 0,12070215 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03216975 0,12050557 ! mRNA stabilization GO:0048255 15 6 0,000 0,03216975 0,12030963 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03216975 0,12011432 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03216975 0,11991964 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03216975 0,1197256 ! opsonization GO:0008228 8 6 0,000 0,03216975 0,11953218 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03216975 0,11933939 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03216975 0,11914722 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03216975 0,11895566 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03216975 0,11876472 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03216975 0,11857439 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03216975 0,11838467 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03216975 0,11819556 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03216975 0,11800705 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03216975 0,11781914 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03216975 0,11763183 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03216975 0,11744511 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03216975 0,11725899 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03216975 0,11707345 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03216975 0,1168885 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03216975 0,11670413 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03216975 0,11652035 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03216975 0,11633714 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03216975 0,11615451 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03216975 0,11597245 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03216975 0,11579096 ! thymic T cell selection GO:0045061 12 6 0,000 0,03216975 0,11561003 ! protein lipoylation GO:0009249 10 6 0,000 0,03216975 0,11542967 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03216975 0,11524988 ! pigment granule organization GO:0048753 11 6 0,000 0,03216975 0,11507064 ! drug transport GO:0015893 6 6 0,000 0,03216975 0,11489196 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03216975 0,11471383 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03216975 0,11453626 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03216975 0,11435923 ! histidine metabolic process GO:0006547 6 6 0,000 0,03216975 0,11418275 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03216975 0,11400681 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03216975 0,11383142 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03216975 0,11365656 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03216975 0,11348224 ! adenohypophysis development GO:0021984 10 6 0,000 0,03216975 0,11330845 ! hyperosmotic response GO:0006972 8 6 0,000 0,03216975 0,1131352 ! microtubule nucleation GO:0007020 10 6 0,000 0,03216975 0,11296247 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03216975 0,11279028 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03216975 0,1126186 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03216975 0,11244745 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03216975 0,11227681 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03216975 0,1121067 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03216975 0,1119371 ! response to dietary excess GO:0002021 7 6 0,000 0,03216975 0,11176801 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03216975 0,11159943 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03216975 0,11143136 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03216975 0,11126379 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03216975 0,11109673 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03216975 0,11093017 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03216975 0,1107641 ! neuron apoptosis GO:0051402 8 6 0,000 0,03216975 0,11059854 ! organic alcohol transport GO:0015850 9 6 0,000 0,03216975 0,11043346 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03216975 0,11026888 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03216975 0,11010479 ! carnitine transport GO:0015879 8 6 0,000 0,03216975 0,10994119 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03216975 0,10977807 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03216975 0,10961544 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03216975 0,10945329 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03216975 0,10929161 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03216975 0,10913041 ! parturition GO:0007567 12 6 0,000 0,03216975 0,10896969 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03216975 0,10880944 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03216975 0,10864966 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03216975 0,10849035 ! spindle checkpoint GO:0031577 14 6 0,000 0,03216975 0,10833151 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03216975 0,10817313 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03216975 0,10801521 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03216975 0,10785776 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03216975 0,10770076 ! astrocyte development GO:0014002 14 6 0,000 0,03216975 0,10754422 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03216975 0,10738813 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03216975 0,10723249 ! interaction with symbiont GO:0051702 8 6 0,000 0,03216975 0,10707731 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03216975 0,10692257 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03216975 0,10676828 ! eating behavior GO:0042755 6 6 0,000 0,03216975 0,10661444 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03216975 0,10646104 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03216975 0,10630808 ! response to copper ion GO:0046688 9 6 0,000 0,03216975 0,10615555 ! DNA topological change GO:0006265 8 6 0,000 0,03216975 0,10600347 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03216975 0,10585182 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03216975 0,1057006 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03216975 0,10554982 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03216975 0,10539946 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03216975 0,10524953 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03216975 0,10510003 ! gas homeostasis GO:0033483 11 6 0,000 0,03216975 0,10495095 ! hair follicle maturation GO:0048820 7 6 0,000 0,03216975 0,1048023 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03216975 0,10465406 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03216975 0,10450624 ! Schwann cell development GO:0014044 14 6 0,000 0,03216975 0,10435884 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03216975 0,10421186 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03216975 0,10406529 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03216975 0,10391913 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03216975 0,10377338 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,03216975 0,10362804 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03216975 0,10348311 ! histone ubiquitination GO:0016574 7 6 0,000 0,03216975 0,10333858 ! regulation of meiosis GO:0040020 10 6 0,000 0,03216975 0,10319445 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03216975 0,10305073 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03216975 0,1029074 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03216975 0,10276447 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03216975 0,10262194 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03216975 0,10247981 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03216975 0,10233806 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03216975 0,10219671 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03216975 0,10205575 ! receptor internalization GO:0031623 9 6 0,000 0,03216975 0,10191518 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03216975 0,10177499 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03216975 0,10163519 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03216975 0,10149578 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03216975 0,10135674 ! protein deubiquitination GO:0016579 8 6 0,000 0,03216975 0,10121809 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03216975 0,10107981 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03216975 0,10094191 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03216975 0,10080439 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03216975 0,10066724 ! midbrain development GO:0030901 6 6 0,000 0,03216975 0,10053046 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03216975 0,10039406 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03216975 0,10025802 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03216975 0,10012236 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03216975 0,09998706 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03216975 0,09985212 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03216975 0,09971755 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03216975 0,09958334 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03216975 0,09944949 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03216975 0,099316 ! adult feeding behavior GO:0008343 6 6 0,000 0,03216975 0,09918287 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03216975 0,09905009 ! blastocyst growth GO:0001832 15 6 0,000 0,03216975 0,09891767 ! pigment granule transport GO:0051904 12 6 0,000 0,03216975 0,09878561 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03216975 0,09865389 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03216975 0,09852253 ! catecholamine transport GO:0051937 7 6 0,000 0,03216975 0,09839152 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03216975 0,09826085 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03216975 0,09813053 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03216975 0,09800056 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03216975 0,09787093 ! protein prenylation GO:0018342 10 6 0,000 0,03216975 0,09774164 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03216975 0,09761269 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,03216975 0,09748409 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03216975 0,09735582 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03216975 0,09722789 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03216975 0,09710029 ! regulation of cellular component size GO:0032535 74 52 1,000 0,03249781 0,09796193 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,03249781 0,09783371 ! aging GO:0007568 79 52 1,000 0,03249781 0,09770582 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,03249781 0,09757827 ! regulation of mitosis GO:0007088 84 54 1,000 0,03482797 0,10443851 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,03482797 0,10430252 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,03482797 0,10416689 ! nucleoside metabolic process GO:0009116 69 55 1,000 0,03601679 0,10758262 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,0374309 0,11166157 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,0374309 0,11151693 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,0374309 0,11137266 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,0374309 0,11122877 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0374309 0,11108525 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,0374309 0,1109421 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0374309 0,11079932 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,0374309 0,1106569 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,0374309 0,11051485 ! reproductive behavior GO:0019098 12 7 0,000 0,0374309 0,11037316 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,0374309 0,11023184 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,0374309 0,11009088 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,0374309 0,10995028 ! oligopeptide transport GO:0006857 11 7 0,000 0,0374309 0,10981004 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,0374309 0,10967015 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,0374309 0,10953062 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,0374309 0,10939145 ! RNA methylation GO:0001510 11 7 0,000 0,0374309 0,10925262 ! pericardium development GO:0060039 8 7 0,000 0,0374309 0,10911415 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,0374309 0,10897604 ! fibril organization GO:0043206 13 7 0,000 0,0374309 0,10883827 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,0374309 0,10870084 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,0374309 0,10856377 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,0374309 0,10842704 ! lipoprotein transport GO:0042953 9 7 0,000 0,0374309 0,10829065 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,0374309 0,10815461 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,0374309 0,10801891 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,0374309 0,10788354 ! estrogen metabolic process GO:0008210 14 7 0,000 0,0374309 0,10774852 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,0374309 0,10761384 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,0374309 0,10747949 ! chemosensory behavior GO:0007635 9 7 0,000 0,0374309 0,10734547 ! microtubule bundle formation GO:0001578 8 7 0,000 0,0374309 0,10721179 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,0374309 0,10707844 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,0374309 0,10694543 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,0374309 0,10681274 ! leukocyte degranulation GO:0043299 10 7 0,000 0,0374309 0,10668038 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,0374309 0,10654835 ! reflex GO:0060004 12 7 0,000 0,0374309 0,10641665 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,0374309 0,10628527 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,0374309 0,10615421 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0374309 0,10602348 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,0374309 0,10589307 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,0374309 0,10576298 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0374309 0,10563321 ! spinal cord patterning GO:0021511 7 7 0,000 0,0374309 0,10550376 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,0374309 0,10537462 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,0374309 0,1052458 ! adrenal gland development GO:0030325 17 7 0,000 0,0374309 0,1051173 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,0374309 0,10498911 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,0374309 0,10486123 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,0374309 0,10473366 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! proline metabolic process GO:0006560 8 7 0,000 0,0374309 0,1046064 ! endosome organization GO:0007032 10 7 0,000 0,0374309 0,10447945 ! thyroid hormone generation GO:0006590 11 7 0,000 0,0374309 0,10435281 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,0374309 0,10422647 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,0374309 0,10410045 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,0374309 0,10397472 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0374309 0,1038493 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,0374309 0,10372418 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,0374309 0,10359936 ! galactose metabolic process GO:0006012 10 7 0,000 0,0374309 0,10347484 ! vesicle fusion GO:0006906 15 7 0,000 0,0374309 0,10335062 ! intracellular pH reduction GO:0051452 10 7 0,000 0,0374309 0,1032267 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,0374309 0,10310308 ! organ growth GO:0035265 11 7 0,000 0,0374309 0,10297975 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,0374309 0,10285671 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,0374309 0,10273397 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,0374309 0,10261152 ! retinol metabolic process GO:0042572 9 7 0,000 0,0374309 0,10248937 ! behavioral fear response GO:0001662 13 7 0,000 0,0374309 0,1023675 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,0374309 0,10224592 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,0374309 0,10212464 ! rRNA modification GO:0000154 12 7 0,000 0,0374309 0,10200364 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,0374309 0,10188292 ! response to UV-B GO:0010224 11 7 0,000 0,0374309 0,10176249 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,0374309 0,10164235 ! intermediate filament organization GO:0045109 11 7 0,000 0,0374309 0,10152249 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,0374309 0,10140291 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,0374309 0,10128361 ! fibrinolysis GO:0042730 9 7 0,000 0,0374309 0,10116459 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,0374309 0,10104585 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,0374309 0,1009274 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,0374309 0,10080921 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,0374309 0,10069131 ! response to tropane GO:0014073 13 7 0,000 0,0374309 0,10057368 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,0374309 0,10045632 ! melanosome localization GO:0032400 10 7 0,000 0,0374309 0,10033924 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,0374309 0,10022243 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,0374309 0,10010589 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,0374309 0,09998963 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,0374309 0,09987363 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,0374309 0,0997579 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,0374309 0,09964244 ! multicellular organismal aging GO:0010259 11 7 0,000 0,0374309 0,09952725 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,0374309 0,09941232 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,0374309 0,09929766 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,0374309 0,09918326 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,0374309 0,09906912 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,0374309 0,09895525 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,0374309 0,09884164 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,0374309 0,09872829 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,0374309 0,0986152 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,0374309 0,09850237 ! regulation of lipid transport GO:0032368 13 7 0,000 0,0374309 0,09838979 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,0374309 0,09827747 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,0374309 0,09816541 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,0374309 0,09805361 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,0374309 0,09794206 ! diuresis GO:0030146 12 7 0,000 0,0374309 0,09783076 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,0374309 0,09771971 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,0374309 0,09760892 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0374309 0,09749838 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,0374309 0,09738809 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,0374309 0,09727804 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,0374309 0,09716825 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,0374309 0,0970587 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,0374309 0,0969494 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,0374309 0,09684035 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,0374309 0,09673154 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,0374309 0,09662297 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,0374309 0,09651465 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,0374309 0,09640657 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,0374309 0,09629873 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,0374309 0,09619114 ! ATP catabolic process GO:0006200 10 7 0,000 0,0374309 0,09608378 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,0374309 0,09597666 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,0374309 0,09586979 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,0374309 0,09576315 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,0374309 0,09565674 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,0374309 0,09555057 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,0374309 0,09544464 ! muscle adaptation GO:0043500 12 7 0,000 0,0374309 0,09533895 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,0374309 0,09523348 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,0374309 0,09512825 ! retina homeostasis GO:0001895 9 7 0,000 0,0374309 0,09502325 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,0374309 0,09491849 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,0374309 0,09481395 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,0374309 0,09470965 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,0374309 0,09460557 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,0374309 0,09450172 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,0374309 0,0943981 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,0374309 0,09429471 ! chromosome segregation GO:0007059 83 57 1,000 0,03844089 0,09673308 ! viral reproductive process GO:0022415 87 58 1,000 0,03967576 0,09973143 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,0421902 0,10593609 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04266375 0,10700831 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04266375 0,10689175 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,04266375 0,10677543 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04266375 0,10665937 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04266375 0,10654357 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04266375 0,10642801 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04266375 0,1063127 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,04266375 0,10619765 ! phosphate transport GO:0006817 10 8 0,000 0,04266375 0,10608284 ! N-glycan processing GO:0006491 12 8 0,000 0,04266375 0,10596828 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04266375 0,10585396 ! UTP metabolic process GO:0046051 8 8 0,000 0,04266375 0,1057399 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04266375 0,10562608 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04266375 0,1055125 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,04266375 0,10539917 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04266375 0,10528608 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,04266375 0,10517323 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,04266375 0,10506063 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04266375 0,10494826 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,04266375 0,10483614 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,04266375 0,10472425 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,04266375 0,10461261 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04266375 0,1045012 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04266375 0,10439003 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04266375 0,10427909 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04266375 0,10416839 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,04266375 0,10405793 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04266375 0,1039477 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04266375 0,1038377 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04266375 0,10372793 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04266375 0,1036184 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04266375 0,1035091 ! astrocyte differentiation GO:0048708 16 8 0,000 0,04266375 0,10340003 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04266375 0,10329118 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04266375 0,10318257 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04266375 0,10307419 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04266375 0,10296603 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04266375 0,1028581 ! melanin metabolic process GO:0006582 12 8 0,000 0,04266375 0,10275039 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04266375 0,10264291 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04266375 0,10253566 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,04266375 0,10242863 ! macrophage activation GO:0042116 12 8 0,000 0,04266375 0,10232182 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04266375 0,10221523 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04266375 0,10210887 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04266375 0,10200273 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04266375 0,10189681 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04266375 0,1017911 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04266375 0,10168562 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04266375 0,10158036 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04266375 0,10147531 ! ruffle organization GO:0031529 11 8 0,000 0,04266375 0,10137048 ! osteoblast development GO:0002076 13 8 0,000 0,04266375 0,10126587 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04266375 0,10116147 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04266375 0,10105729 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04266375 0,10095332 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04266375 0,10084956 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04266375 0,10074602 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,04266375 0,10064269 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,04266375 0,10053957 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04266375 0,10043667 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04266375 0,10033397 ! brain morphogenesis GO:0048854 20 8 0,000 0,04266375 0,10023149 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04266375 0,10012921 ! segment specification GO:0007379 10 8 0,000 0,04266375 0,10002714 ! cellular extravasation GO:0045123 11 8 0,000 0,04266375 0,09992528 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04266375 0,09982363 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04266375 0,09972218 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04266375 0,09962094 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04266375 0,0995199 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04266375 0,09941907 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04266375 0,09931845 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04266375 0,09921802 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,04266375 0,0991178 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04266375 0,09901778 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04266375 0,09891797 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04266375 0,09881835 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04266375 0,09871894 ! icosanoid secretion GO:0032309 12 8 0,000 0,04266375 0,09861972 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04266375 0,09852071 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04266375 0,09842189 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04266375 0,09832327 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04266375 0,09822485 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04266375 0,09812662 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04266375 0,0980286 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04266375 0,09793076 ! sterol catabolic process GO:0016127 9 8 0,000 0,04266375 0,09783313 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04266375 0,09773568 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04266375 0,09763843 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04266375 0,09754138 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04266375 0,09744451 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04266375 0,09734784 ! prophase GO:0051324 11 8 0,000 0,04266375 0,09725136 ! S phase GO:0051320 8 8 0,000 0,04266375 0,09715507 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04266375 0,09705898 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04266375 0,09696307 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04266375 0,09686735 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04266375 0,09677182 ! hormone catabolic process GO:0042447 13 8 0,000 0,04266375 0,09667648 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04266375 0,09658132 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04266375 0,09648636 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04266375 0,09639158 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04266375 0,09629698 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04266375 0,09620257 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,04266375 0,09610835 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04266375 0,09601431 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04266375 0,09592045 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04266375 0,09582678 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04266375 0,09573329 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04266375 0,09563998 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04266375 0,09554686 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04266375 0,09545391 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,04266375 0,09536115 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,04266375 0,09526857 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,04346937 0,09697338 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,04607065 0,10267683 GO:0090046|regulation of transcription regulator activity, ! viral reproduction GO:0016032 92 63 1,000 0,04607065 0,10257743 ! regulation of lipase activity GO:0060191 109 63 1,000 0,04607065 0,10247823 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,04739238 0,10531639 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,04739238 0,10521474 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,04786845 0,10616918 ! telencephalon cell migration GO:0022029 16 9 0,000 0,04786845 0,10606689 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,04786845 0,10596481 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04786845 0,10586292 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04786845 0,10576123 ! CTP metabolic process GO:0046036 9 9 0,000 0,04786845 0,10565973 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04786845 0,10555842 ! GTP metabolic process GO:0046039 9 9 0,000 0,04786845 0,10545731 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04786845 0,1053564 ! social behavior GO:0035176 14 9 0,000 0,04786845 0,10525568 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,04786845 0,10515514 ! artery development GO:0060840 19 9 0,000 0,04786845 0,10505481 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04786845 0,10495466 ! response to pain GO:0048265 16 9 0,000 0,04786845 0,1048547 ! protein complex disassembly GO:0043241 17 9 0,000 0,04786845 0,10475493 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04786845 0,10465536 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04786845 0,10455597 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,04786845 0,10445677 ! lung alveolus development GO:0048286 17 9 0,000 0,04786845 0,10435776 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04786845 0,10425894 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,04786845 0,1041603 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04786845 0,10406185 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04786845 0,10396359 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04786845 0,10386551 ! protein targeting to ER GO:0045047 19 9 0,000 0,04786845 0,10376761 ! T cell selection GO:0045058 18 9 0,000 0,04786845 0,1036699 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04786845 0,10357238 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04786845 0,10347503 ! arginine catabolic process GO:0006527 10 9 0,000 0,04786845 0,10337787 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,04786845 0,1032809 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,04786845 0,1031841 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,04786845 0,10308749 ! V(D)J recombination GO:0033151 12 9 0,000 0,04786845 0,10299105 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,04786845 0,1028948 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04786845 0,10279873 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04786845 0,10270283 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04786845 0,10260712 ! mannose metabolic process GO:0006013 9 9 0,000 0,04786845 0,10251158 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04786845 0,10241622 ! receptor clustering GO:0043113 15 9 0,000 0,04786845 0,10232104 ! epithelial cell development GO:0002064 10 9 0,000 0,04786845 0,10222603 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04786845 0,1021312 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04786845 0,10203655 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,04786845 0,10194207 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04786845 0,10184777 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04786845 0,10175364 ! motor axon guidance GO:0008045 14 9 0,000 0,04786845 0,10165968 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,04786845 0,1015659 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,04786845 0,10147229 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,04786845 0,10137886 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,04786845 0,10128559 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04786845 0,1011925 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04786845 0,10109957 ! DNA ligation GO:0006266 14 9 0,000 0,04786845 0,10100682 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04786845 0,10091424 ! response to amine stimulus GO:0014075 13 9 0,000 0,04786845 0,10082183 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04786845 0,10072959 ! erythrocyte development GO:0048821 11 9 0,000 0,04786845 0,10063751 ! renal water homeostasis GO:0003091 14 9 0,000 0,04786845 0,1005456 ! mRNA cleavage GO:0006379 13 9 0,000 0,04786845 0,10045387 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04786845 0,10036229 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,04786845 0,10027089 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04786845 0,10017965 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04786845 0,10008858 ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04786845 0,09999767 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,04786845 0,09990693 ! acid secretion GO:0046717 14 9 0,000 0,04786845 0,09981635 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04786845 0,09972594 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04786845 0,09963569 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04786845 0,0995456 ! purine base metabolic process GO:0006144 18 9 0,000 0,04786845 0,09945568 ! oocyte differentiation GO:0009994 12 9 0,000 0,04786845 0,09936592 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,04786845 0,09927632 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04786845 0,09918688 ! spleen development GO:0048536 15 9 0,000 0,04786845 0,0990976 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,04786845 0,09900849 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04786845 0,09891953 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04786845 0,09883073 ! detection of calcium ion GO:0005513 13 9 0,000 0,04786845 0,0987421 ! blastocyst formation GO:0001825 12 9 0,000 0,04786845 0,09865362 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04786845 0,0985653 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,04786845 0,09847713 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04786845 0,09838913 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04786845 0,09830128 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04786845 0,09821359 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04786845 0,09812606 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,04786845 0,09803868 ! prepulse inhibition GO:0060134 14 9 0,000 0,04786845 0,09795146 ! embryonic placenta development GO:0001892 12 9 0,000 0,04786845 0,09786439 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,04786845 0,09777747 ! insulin secretion GO:0030073 17 9 0,000 0,04786845 0,09769072 ! sequestering of metal ion GO:0051238 11 9 0,000 0,04786845 0,09760411 ! response to nicotine GO:0035094 16 9 0,000 0,04786845 0,09751766 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04786845 0,09743136 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04786845 0,09734521 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,05007708 0,10174672 ! regulation of immune effector process GO:0002697 101 66 1,000 0,05007708 0,10165692 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,05143969 0,10433094 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,05281556 0,10702712 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,05304515 0,10739775 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05304515 0,1073033 ! neuron fate specification GO:0048665 11 10 0,000 0,05304515 0,10720901 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,05304515 0,10711488 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05304515 0,10702092 ! thyroid gland development GO:0030878 19 10 0,000 0,05304515 0,10692712 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,05304515 0,10683349 ! synapsis GO:0007129 13 10 0,000 0,05304515 0,10674003 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,05304515 0,10664672 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,05304515 0,10655358 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05304515 0,1064606 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,05304515 0,10636778 ! sulfate transport GO:0008272 12 10 0,000 0,05304515 0,10627513 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05304515 0,10618264 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,05304515 0,1060903 ! phospholipid efflux GO:0033700 16 10 0,000 0,05304515 0,10599813 ! blood vessel remodeling GO:0001974 21 10 0,000 0,05304515 0,10590612 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,05304515 0,10581427 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,05304515 0,10572257 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,05304515 0,10563104 GO:0010812|negative regulation of cell-substrate adhesion, ! pathogenesis GO:0009405 13 10 0,000 0,05304515 0,10553966 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,05304515 0,10544844 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05304515 0,10535738 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05304515 0,10526648 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,05304515 0,10517573 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,05304515 0,10508514 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05304515 0,10499471 ! melanocyte differentiation GO:0030318 15 10 0,000 0,05304515 0,10490443 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,05304515 0,1048143 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05304515 0,10472433 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05304515 0,10463452 ! B cell proliferation GO:0042100 14 10 0,000 0,05304515 0,10454486 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05304515 0,10445535 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05304515 0,104366 ! forebrain cell migration GO:0021885 17 10 0,000 0,05304515 0,10427679 ! lipid digestion GO:0044241 15 10 0,000 0,05304515 0,10418774 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,05304515 0,10409885 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05304515 0,1040101 ! UV protection GO:0009650 14 10 0,000 0,05304515 0,10392151 ! entry into host cell GO:0030260 20 10 0,000 0,05304515 0,10383306 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,05304515 0,10374477 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05304515 0,10365663 ! negative regulation of ossification GO:0030279 19 10 0,000 0,05304515 0,10356863 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,05304515 0,10348079 ! regulation of bone resorption GO:0045124 24 10 0,000 0,05304515 0,10339309 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,05304515 0,10330555 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,05304515 0,10321815 ! regulation of organ growth GO:0046620 11 10 0,000 0,05304515 0,1031309 ! response to dsRNA GO:0043331 18 10 0,000 0,05304515 0,10304379 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,05304515 0,10295683 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05304515 0,10287002 ! embryonic axis specification GO:0000578 12 10 0,000 0,05304515 0,10278336 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,05304515 0,10269684 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05304515 0,10261047 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,05304515 0,10252424 ! cranial nerve development GO:0021545 12 10 0,000 0,05304515 0,10243816 ! fucose catabolic process GO:0019317 16 10 0,000 0,05304515 0,10235222 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,05304515 0,10226643 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,05304515 0,10218078 ! protein sumoylation GO:0016925 12 10 0,000 0,05304515 0,10209527 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05304515 0,10200991 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05304515 0,10192469 ! zymogen activation GO:0031638 14 10 0,000 0,05304515 0,10183961 ! salivary gland development GO:0007431 22 10 0,000 0,05304515 0,10175467 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05304515 0,10166987 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05304515 0,10158522 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,05304515 0,10150071 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05304515 0,10141633 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,05304515 0,1013321 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05304515 0,10124801 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05304515 0,10116405 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05304515 0,10108024 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,05304515 0,10099656 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,05304515 0,10091303 ! embryonic gut development GO:0048566 11 10 0,000 0,05304515 0,10082963 ! activation of innate immune response GO:0002218 10 10 0,000 0,05304515 0,10074637 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05304515 0,10066324 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,05304515 0,10058025 ! developmental induction GO:0031128 13 10 0,000 0,05304515 0,1004974 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05304515 0,10041469 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,05304515 0,10033211 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05304515 0,10024967 ! response to drug GO:0042493 108 69 1,000 0,0542045 0,10235661 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,0542045 0,10227264 ! response to metal ion GO:0010038 103 70 1,000 0,05560634 0,10483163 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,05560634 0,10474577 ! regulation of catabolic process GO:0009894 106 70 1,000 0,05560634 0,10466005 ! muscle cell differentiation GO:0042692 104 71 1,000 0,0570209 0,10723473 ! rRNA transcription GO:0009303 17 11 0,000 0,058194 0,10935147 ! respiratory burst GO:0045730 14 11 0,000 0,058194 0,10926221 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,058194 0,10917309 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,058194 0,10908411 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,058194 0,10899528 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,058194 0,10890659 ! RNA polyadenylation GO:0043631 19 11 0,000 0,058194 0,10881805 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,058194 0,10872965 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,058194 0,1086414 ! mating GO:0007618 14 11 0,000 0,058194 0,10855329 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,058194 0,10846532 ! T cell proliferation GO:0042098 20 11 0,000 0,058194 0,10837749 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,058194 0,10828981 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,058194 0,10820227 ! bone resorption GO:0045453 16 11 0,000 0,058194 0,10811487 ! regulated secretory pathway GO:0045055 14 11 0,000 0,058194 0,10802761 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,058194 0,10794049 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,058194 0,10785351 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,058194 0,10776667 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,058194 0,10767997 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,058194 0,10759341 ! syncytium formation GO:0006949 15 11 0,000 0,058194 0,10750699 ! plasma membrane organization GO:0007009 18 11 0,000 0,058194 0,10742071 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,058194 0,10733457 ! focal adhesion formation GO:0048041 24 11 0,000 0,058194 0,10724856 ! mitotic spindle organization GO:0007052 15 11 0,000 0,058194 0,10716269 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,058194 0,10707696 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,058194 0,10699137 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,058194 0,10690591 ! adult heart development GO:0007512 11 11 0,000 0,058194 0,10682059 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,058194 0,10673541 ! temperature homeostasis GO:0001659 16 11 0,000 0,058194 0,10665036 ! L-glutamate transport GO:0015813 16 11 0,000 0,058194 0,10656545 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,058194 0,10648067 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,058194 0,10639603 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,058194 0,10631152 ! stem cell development GO:0048864 29 11 0,000 0,058194 0,10622715 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,058194 0,10614291 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,058194 0,1060588 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,058194 0,10597483 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,058194 0,10589098 ! vasoconstriction GO:0042310 15 11 0,000 0,058194 0,10580728 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,058194 0,1057237 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,058194 0,10564026 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,058194 0,10555694 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,058194 0,10547376 ! ribosome assembly GO:0042255 13 11 0,000 0,058194 0,10539071 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,058194 0,10530779 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,058194 0,105225 ! chromatin silencing GO:0006342 19 11 0,000 0,058194 0,10514234 ! nucleosome positioning GO:0016584 13 11 0,000 0,058194 0,10505982 ! T cell homeostasis GO:0043029 20 11 0,000 0,058194 0,10497742 ! regulation of isotype switching GO:0045191 19 11 0,000 0,058194 0,10489514 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,058194 0,104813 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,058194 0,10473099 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,058194 0,1046491 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,058194 0,10456735 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,058194 0,10448572 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,058194 0,10440422 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,058194 0,10432284 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,058194 0,10424159 ! male genitalia development GO:0030539 13 11 0,000 0,058194 0,10416047 ! cholesterol efflux GO:0033344 19 11 0,000 0,058194 0,10407947 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,058194 0,1039986 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,058194 0,10391786 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,058194 0,10383724 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,058194 0,10375675 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,058194 0,10367638 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,058194 0,10359613 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,058194 0,10351601 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,058194 0,10343602 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,058194 0,10335614 ! lysogeny GO:0030069 18 11 0,000 0,058194 0,10327639 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,058194 0,10319677 ! acrosome reaction GO:0007340 13 11 0,000 0,058194 0,10311726 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,058194 0,10303788 ! response to hypoxia GO:0001666 132 72 1,000 0,05844801 0,10340802 ! mitochondrion organization GO:0007005 104 73 1,000 0,05988749 0,10587334 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,05988749 0,10579203 ! response to oxygen levels GO:0070482 137 74 1,000 0,06133916 0,10827327 ! response to inorganic substance GO:0010035 115 75 1,000 0,06280286 0,11077191 ! lactation GO:0007595 20 12 0,000 0,06331515 0,11158992 ! reproductive cellular process GO:0048610 14 12 0,000 0,06331515 0,11150447 ! tRNA modification GO:0006400 14 12 0,000 0,06331515 0,11141916 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,06331515 0,11133398 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,06331515 0,11124893 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,06331515 0,111164 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,06331515 0,11107921 ! non-recombinational repair GO:0000726 19 12 0,000 0,06331515 0,11099455 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,06331515 0,11091001 ! peroxisomal transport GO:0043574 21 12 0,000 0,06331515 0,1108256 ! cartilage condensation GO:0001502 18 12 0,000 0,06331515 0,11074133 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,06331515 0,11065718 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,06331515 0,11057315 ! heart looping GO:0001947 15 12 0,000 0,06331515 0,11048926 ! palate development GO:0060021 15 12 0,000 0,06331515 0,11040549 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,06331515 0,11032185 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,06331515 0,11023834 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,06331515 0,11015495 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,06331515 0,11007169 ! arginine metabolic process GO:0006525 13 12 0,000 0,06331515 0,10998855 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,06331515 0,10990554 ! methionine metabolic process GO:0006555 13 12 0,000 0,06331515 0,10982266 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,06331515 0,1097399 ! Golgi organization GO:0007030 18 12 0,000 0,06331515 0,10965726 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,06331515 0,10957475 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,06331515 0,10949236 ! monoamine transport GO:0015844 13 12 0,000 0,06331515 0,1094101 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06331515 0,10932796 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,06331515 0,10924594 ! L-amino acid transport GO:0015807 20 12 0,000 0,06331515 0,10916405 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,06331515 0,10908228 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,06331515 0,10900063 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,06331515 0,10891911 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06331515 0,1088377 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,06331515 0,10875642 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,06331515 0,10867526 ! cerebellum development GO:0021549 13 12 0,000 0,06331515 0,10859422 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,06331515 0,1085133 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,06331515 0,1084325 ! histone methylation GO:0016571 15 12 0,000 0,06331515 0,10835182 ! autonomic nervous system development GO:0048483 23 12 0,000 0,06331515 0,10827126 ! gland morphogenesis GO:0022612 23 12 0,000 0,06331515 0,10819082 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,06331515 0,1081105 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,06331515 0,1080303 ! regulation of epidermis development GO:0045682 17 12 0,000 0,06331515 0,10795022 ! intestinal absorption GO:0050892 19 12 0,000 0,06331515 0,10787025 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,06331515 0,10779041 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,06331515 0,10771068 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,06331515 0,10763107 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,06331515 0,10755158 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,06331515 0,10747221 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,06331515 0,10739295 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,06331515 0,10731381 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,06331515 0,10723479 ! response to cold GO:0009409 14 12 0,000 0,06331515 0,10715588 ! regulation of protein transport GO:0051223 114 76 1,000 0,06427841 0,10870613 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 1,000 0,06576564 0,11113959 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,06576564 0,11105798 ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,06726439 0,11350558 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,06840874 0,11535198 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,06840874 0,11526748 ! cGMP metabolic process GO:0046068 16 13 0,000 0,06840874 0,11518309 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,06840874 0,11509883 ! water transport GO:0006833 17 13 0,000 0,06840874 0,1150147 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,06840874 0,11493068 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,06840874 0,11484679 ! lipid localization GO:0010876 24 13 0,000 0,06840874 0,11476302 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,06840874 0,11467938 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,06840874 0,11459585 ! organelle fusion GO:0048284 28 13 0,000 0,06840874 0,11451245 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,06840874 0,11442917 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,06840874 0,11434601 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,06840874 0,11426297 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,06840874 0,11418005 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,06840874 0,11409725 ! response to hexose stimulus GO:0009746 19 13 0,000 0,06840874 0,11401457 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,06840874 0,11393201 ! glutamate metabolic process GO:0006536 18 13 0,000 0,06840874 0,11384957 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,06840874 0,11376725 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,06840874 0,11368505 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,06840874 0,11360297 ! NAD metabolic process GO:0019674 21 13 0,000 0,06840874 0,113521 ! exocrine system development GO:0035272 27 13 0,000 0,06840874 0,11343915 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,06840874 0,11335743 ! bone mineralization GO:0030282 15 13 0,000 0,06840874 0,11327581 ! regulation of exocytosis GO:0017157 17 13 0,000 0,06840874 0,11319432 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,06840874 0,11311295 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,06840874 0,11303169 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,06840874 0,11295054 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,06840874 0,11286952 ! genitalia development GO:0048806 15 13 0,000 0,06840874 0,11278861 ! cellular pigmentation GO:0033059 24 13 0,000 0,06840874 0,11270781 ! tissue regeneration GO:0042246 21 13 0,000 0,06840874 0,11262713 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,06840874 0,11254657 ! cofactor transport GO:0051181 19 13 0,000 0,06840874 0,11246612 ! NADP metabolic process GO:0006739 18 13 0,000 0,06840874 0,11238579 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,06840874 0,11230557 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,06840874 0,11222547 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,06840874 0,11214548 ! gas transport GO:0015669 18 13 0,000 0,06840874 0,1120656 ! heme biosynthetic process GO:0006783 20 13 0,000 0,06840874 0,11198584 ! regulation of axon extension GO:0030516 23 13 0,000 0,06840874 0,11190619 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,06840874 0,11182666 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,06840874 0,11174723 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,06840874 0,11166793 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,06840874 0,11158873 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,06840874 0,11150964 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,06840874 0,11143067 ! forebrain development GO:0030900 131 80 1,000 0,07029579 0,11442344 ! mRNA transport GO:0051028 121 81 1,000 0,07182811 0,11683497 ! ossification GO:0001503 134 82 1,000 0,07337128 0,11926075 GO:0060348|bone development, ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,07347493 0,11934487 ! superoxide anion generation GO:0042554 18 14 0,000 0,07347493 0,11926064 ! neuron maturation GO:0042551 21 14 0,000 0,07347493 0,11917654 ! regulation of S phase GO:0033261 18 14 0,000 0,07347493 0,11909255 ! myotube differentiation GO:0014902 21 14 0,000 0,07347493 0,11900868 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,07347493 0,11892493 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,07347493 0,1188413 ! inositol metabolic process GO:0006020 20 14 0,000 0,07347493 0,11875779 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,07347493 0,11867439 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,07347493 0,11859111 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,07347493 0,11850795 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,07347493 0,1184249 ! gene silencing by RNA GO:0031047 20 14 0,000 0,07347493 0,11834197 ! response to cAMP GO:0051591 19 14 0,000 0,07347493 0,11825915 ! startle response GO:0001964 21 14 0,000 0,07347493 0,11817645 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,07347493 0,11809387 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,07347493 0,1180114 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,07347493 0,11792905 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,07347493 0,11784681 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,07347493 0,11776469 ! glycine metabolic process GO:0006544 22 14 0,000 0,07347493 0,11768268 ! pituitary gland development GO:0021983 23 14 0,000 0,07347493 0,11760079 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,07347493 0,11751901 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,07347493 0,11743734 ! regulation of heart rate GO:0002027 23 14 0,000 0,07347493 0,11735578 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,07347493 0,11727434 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,07347493 0,11719302 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,07347493 0,1171118 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,07347493 0,1170307 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,07347493 0,11694971 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,07347493 0,11686883 ! axon cargo transport GO:0008088 27 14 0,000 0,07347493 0,11678806 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,07347493 0,11670741 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,07347493 0,11662687 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,07347493 0,11654643 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,07347493 0,11646611 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07347493 0,1163859 ! mRNA splice site selection GO:0006376 26 14 0,000 0,07347493 0,1163058 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,07347493 0,11622581 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,07347493 0,11614593 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,07347493 0,11606616 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,07347493 0,1159865 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,07347493 0,11590695 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,07347493 0,11582751 ! muscle maintenance GO:0046716 19 14 0,000 0,07347493 0,11574817 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,07347493 0,11566895 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,07347493 0,11558983 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,07347493 0,11551082 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,07347493 0,11543192 ! cell killing GO:0001906 20 14 0,000 0,07347493 0,11535313 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,07347493 0,11527444 ! cilium assembly GO:0042384 20 14 0,000 0,07347493 0,11519586 ! peptide hormone secretion GO:0030072 23 14 0,000 0,07347493 0,11511739 ! regulation of defense response GO:0031347 117 84 1,000 0,07648959 0,11975905 ! rRNA metabolic process GO:0016072 107 85 1,000 0,07806439 0,12214157 GO:0006364|rRNA processing, ! regulation of protein localization GO:0032880 132 85 1,000 0,07806439 0,12205853 ! positive regulation of cell size GO:0045793 20 15 0,000 0,07851385 0,12267789 ! metencephalon development GO:0022037 19 15 0,000 0,07851385 0,1225946 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,07851385 0,12251143 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,07851385 0,12242837 ! skin development GO:0043588 25 15 0,000 0,07851385 0,12234543 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,07851385 0,12226259 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,07851385 0,12217987 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,07851385 0,12209726 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,07851385 0,12201476 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,07851385 0,12193238 ! bile acid metabolic process GO:0008206 22 15 0,000 0,07851385 0,1218501 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,07851385 0,12176794 ! adult walking behavior GO:0007628 25 15 0,000 0,07851385 0,12168588 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,07851385 0,12160394 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,07851385 0,12152211 ! myoblast differentiation GO:0045445 27 15 0,000 0,07851385 0,12144038 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,07851385 0,12135877 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,07851385 0,12127727 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,07851385 0,12119587 ! cerebral cortex development GO:0021987 29 15 0,000 0,07851385 0,12111459 ! response to osmotic stress GO:0006970 22 15 0,000 0,07851385 0,12103341 ! vesicle coating GO:0006901 25 15 0,000 0,07851385 0,12095234 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,07851385 0,12087139 ! DNA integration GO:0015074 22 15 0,000 0,07851385 0,12079053 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,07851385 0,12070979 ! peptide secretion GO:0002790 27 15 0,000 0,07851385 0,12062916 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,07851385 0,12054863 ! regulation of vasodilation GO:0042312 24 15 0,000 0,07851385 0,12046821 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,07851385 0,1203879 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,07851385 0,12030769 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,07851385 0,1202276 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,07851385 0,1201476 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,07851385 0,12006772 ! biomineral formation GO:0031214 18 15 0,000 0,07851385 0,11998794 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,07851385 0,11990827 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,07851385 0,1198287 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,07851385 0,11974924 ! dopamine metabolic process GO:0042417 30 15 0,000 0,07851385 0,11966988 ! organic cation transport GO:0015695 19 15 0,000 0,07851385 0,11959063 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,07851385 0,11951148 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,07851385 0,11943244 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,07851385 0,1193535 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,07851385 0,11927467 ! peptide hormone processing GO:0016486 19 15 0,000 0,07851385 0,11919594 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,07851385 0,11911732 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,08124454 0,12317893 GO:0060538|skeletal muscle organ development, ! establishment of RNA localization GO:0051236 128 88 1,000 0,08284957 0,12552965 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein secretion GO:0009306 27 16 0,000 0,08352565 0,1264707 ! hormone secretion GO:0046879 25 16 0,000 0,08352565 0,1263875 ! bone remodeling GO:0046849 24 16 0,000 0,08352565 0,1263044 ! endothelial cell migration GO:0043542 22 16 0,000 0,08352565 0,12622142 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,08352565 0,12613854 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08352565 0,12605577 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,08352565 0,12597311 ! glial cell development GO:0021782 24 16 0,000 0,08352565 0,12589056 ! patterning of blood vessels GO:0001569 24 16 0,000 0,08352565 0,12580812 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,08352565 0,12572578 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,08352565 0,12564356 ! protein polyubiquitination GO:0000209 26 16 0,000 0,08352565 0,12556144 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,08352565 0,12547942 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,08352565 0,12539752 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,08352565 0,12531572 ! fructose metabolic process GO:0006000 20 16 0,000 0,08352565 0,12523403 ! regulation of protein binding GO:0043393 27 16 0,000 0,08352565 0,12515244 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,08352565 0,12507096 ! protein export from nucleus GO:0006611 24 16 0,000 0,08352565 0,12498959 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,08352565 0,12490832 ! DNA replication initiation GO:0006270 25 16 0,000 0,08352565 0,12482716 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,08352565 0,1247461 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,08352565 0,12466515 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,08352565 0,12458431 ! diencephalon development GO:0021536 25 16 0,000 0,08352565 0,12450356 ! oogenesis GO:0048477 23 16 0,000 0,08352565 0,12442293 ! neural crest cell migration GO:0001755 24 16 0,000 0,08352565 0,12434239 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,08352565 0,12426197 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,08352565 0,12418164 GO:0006626|protein targeting to mitochondrion, ! steroid catabolic process GO:0006706 22 16 0,000 0,08352565 0,12410142 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,08352565 0,1240213 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,08352565 0,12394129 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,08352565 0,12386138 ! sperm-egg recognition GO:0035036 16 16 0,000 0,08352565 0,12378157 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,08352565 0,12370187 ! nerve development GO:0021675 18 16 0,000 0,08352565 0,12362226 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,08352565 0,12354276 ! negative regulation of translation GO:0017148 22 16 0,000 0,08352565 0,12346337 ! reproductive developmental process GO:0003006 127 89 1,000 0,08446437 0,12477075 ! RNA localization GO:0006403 135 91 1,000 0,08772267 0,12950074 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,08851048 0,13057993 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,08851048 0,13049623 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,08851048 0,13041263 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,08851048 0,13032914 ! glycerol metabolic process GO:0006071 20 17 0,000 0,08851048 0,13024575 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,08851048 0,13016248 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,08851048 0,1300793 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,08851048 0,12999624 ! signal complex assembly GO:0007172 29 17 0,000 0,08851048 0,12991328 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,08851048 0,12983043 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,08851048 0,12974768 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,08851048 0,12966504 ! memory GO:0007613 25 17 0,000 0,08851048 0,1295825 ! keratinization GO:0031424 17 17 0,000 0,08851048 0,12950007 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,08851048 0,12941774 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,08851048 0,12933552 ! retinoid metabolic process GO:0001523 22 17 0,000 0,08851048 0,1292534 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,08851048 0,12917139 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,08851048 0,12908948 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,08851048 0,12900768 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,08851048 0,12892597 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,08851048 0,12884437 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,08851048 0,12876288 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,08851048 0,12868149 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,08851048 0,1286002 ! membrane budding GO:0006900 29 17 0,000 0,08851048 0,12851901 ! heme metabolic process GO:0042168 27 17 0,000 0,08851048 0,12843793 ! actin filament bundle formation GO:0051017 26 17 0,000 0,08851048 0,12835694 ! neuromuscular junction development GO:0007528 23 17 0,000 0,08851048 0,12827606 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,08851048 0,12819528 ! body fluid secretion GO:0007589 27 17 0,000 0,08851048 0,12811461 ! stem cell differentiation GO:0048863 36 17 0,000 0,08851048 0,12803403 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,08851048 0,12795356 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,08851048 0,12787319 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,08851048 0,12779291 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,08851048 0,12771274 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,08851048 0,12763267 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,08851048 0,1275527 ! synaptogenesis GO:0007416 24 17 0,000 0,08851048 0,12747283 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,08851048 0,12739306 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,08851048 0,12731339 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,08851048 0,12723382 ! cell-cell junction organization GO:0045216 25 17 0,000 0,08851048 0,12715435 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,08851048 0,12707498 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,08851048 0,1269957 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,08851048 0,12691653 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,08851048 0,12683745 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,08851048 0,12675848 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,08851048 0,1266796 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,08936588 0,12782433 ! cell fate commitment GO:0045165 141 92 1,000 0,08936588 0,12774488 ! DNA recombination GO:0006310 146 92 1,000 0,08936588 0,12766554 ! sulfur metabolic process GO:0006790 118 92 1,000 0,08936588 0,12758629 ! electron transport chain GO:0022900 123 94 1,000 0,09267966 0,13223525 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,09346849 0,13327806 ! positive regulation of translation GO:0045727 28 18 0,000 0,09346849 0,13319549 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,09346849 0,13311301 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,09346849 0,13303064 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,09346849 0,13294837 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,09346849 0,1328662 ! cAMP metabolic process GO:0046058 33 18 0,000 0,09346849 0,13278414 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,09346849 0,13270217 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,09346849 0,13262031 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,09346849 0,13253854 ! axis specification GO:0009798 26 18 0,000 0,09346849 0,13245688 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,09346849 0,13237532 GO:0050886|endocrine process, ! pancreas development GO:0031016 26 18 0,000 0,09346849 0,13229386 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,09346849 0,13221249 ! glutamine metabolic process GO:0006541 23 18 0,000 0,09346849 0,13213123 ! response to retinoic acid GO:0032526 25 18 0,000 0,09346849 0,13205007 ! pigmentation during development GO:0048066 31 18 0,000 0,09346849 0,13196901 ! central nervous system neuron development GO:0021954 30 18 0,000 0,09346849 0,13188805 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,09346849 0,13180718 ! fucose metabolic process GO:0006004 26 18 0,000 0,09346849 0,13172642 ! response to fungus GO:0009620 19 18 0,000 0,09346849 0,13164575 ! peptide cross-linking GO:0018149 31 18 0,000 0,09346849 0,13156519 ! heart process GO:0003015 27 18 0,000 0,09346849 0,13148472 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,09346849 0,13140435 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,09346849 0,13132408 ! visual learning GO:0008542 35 18 0,000 0,09346849 0,1312439 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,09346849 0,13116383 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,09346849 0,13108385 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,09346849 0,13100397 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,09346849 0,13092419 ! vitamin transport GO:0051180 24 18 0,000 0,09346849 0,1308445 ! hormone transport GO:0009914 27 18 0,000 0,09346849 0,13076491 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,09346849 0,13068542 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,09346849 0,13060602 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,09346849 0,13052672 ! cell-cell recognition GO:0009988 20 18 0,000 0,09346849 0,13044752 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,09346849 0,13036841 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,09346849 0,1302894 ! regulation of glucose import GO:0046324 21 18 0,000 0,09346849 0,13021049 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,09346849 0,13013167 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,09346849 0,13005294 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,09346849 0,12997431 ! regulation of binding GO:0051098 151 95 1,000 0,09434995 0,13112077 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,09602898 0,13337358 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,09602898 0,13329309 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,0977166 0,13555379 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,0983998 0,13641925 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,0983998 0,13633707 ! positive regulation of ossification GO:0045778 30 19 0,000 0,0983998 0,13625499 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,0983998 0,13617301 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,0983998 0,13609113 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,0983998 0,13600934 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,0983998 0,13592765 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,0983998 0,13584606 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,0983998 0,13576457 ! regeneration GO:0031099 32 19 0,000 0,0983998 0,13568318 ! response to alkaloid GO:0043279 32 19 0,000 0,0983998 0,13560188 ! sensory perception of taste GO:0050909 23 19 0,000 0,0983998 0,13552068 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,0983998 0,13543958 ! smooth muscle contraction GO:0006939 36 19 0,000 0,0983998 0,13535858 ! peroxisome organization GO:0007031 29 19 0,000 0,0983998 0,13527767 ! digestive system process GO:0022600 30 19 0,000 0,0983998 0,13519686 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,0983998 0,13511614 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,0983998 0,13503553 ! response to vitamin A GO:0033189 26 19 0,000 0,0983998 0,134955 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,0983998 0,13487458 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,0983998 0,13479425 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,0983998 0,13471401 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,0983998 0,13463387 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,0983998 0,13455383 ! plasma membrane fusion GO:0045026 23 19 0,000 0,0983998 0,13447388 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,0983998 0,13439403 ! cytolysis GO:0019835 20 19 0,000 0,0983998 0,13431427 ! renal system process GO:0003014 35 19 0,000 0,0983998 0,1342346 ! vasodilation GO:0042311 33 19 0,000 0,0983998 0,13415503 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,0983998 0,13407556 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,0983998 0,13399618 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,0983998 0,13391689 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,0983998 0,13383769 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,0983998 0,13375859 ! sarcomere organization GO:0045214 23 19 0,000 0,0983998 0,13367959 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,0983998 0,13360067 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,0983998 0,13352185 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,0983998 0,13344313 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,0983998 0,13336449 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,0983998 0,13328595 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,0983998 0,1332075 ! protein stabilization GO:0050821 26 19 0,000 0,0983998 0,13312914 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,10111709 0,13672505 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,10282967 0,13895901 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,10282967 0,13887742 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,10330457 0,13943692 ! iron ion transport GO:0006826 37 20 0,000 0,10330457 0,13935514 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,10330457 0,13927346 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,10330457 0,13919187 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,10330457 0,13911037 ! response to vitamin GO:0033273 29 20 0,000 0,10330457 0,13902897 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,10330457 0,13894767 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,10330457 0,13886646 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,10330457 0,13878535 ! spinal cord development GO:0021510 31 20 0,000 0,10330457 0,13870433 ! response to ethanol GO:0045471 37 20 0,000 0,10330457 0,1386234 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,10330457 0,13854257 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,10330457 0,13846184 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,10330457 0,1383812 ! chromosome condensation GO:0030261 31 20 0,000 0,10330457 0,13830065 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,10330457 0,13822019 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,10330457 0,13813983 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,10330457 0,13805957 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,10330457 0,13797939 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,10330457 0,13789931 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,10330457 0,13781932 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,10330457 0,13773943 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,10330457 0,13765963 ! collagen catabolic process GO:0030574 25 20 0,000 0,10330457 0,13757992 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,10330457 0,1375003 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,10330457 0,13742077 ! alditol metabolic process GO:0019400 24 20 0,000 0,10330457 0,13734134 ! actin filament-based movement GO:0030048 34 20 0,000 0,10330457 0,137262 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,10818294 0,14366095 GO:0016444|somatic cell DNA recombination, ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,10818294 0,14357805 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,10818294 0,14349525 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,10818294 0,14341254 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,10818294 0,14332993 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,10818294 0,14324742 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,10818294 0,143165 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,10818294 0,14308267 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,10818294 0,14300044 ! vesicle docking GO:0048278 27 21 0,000 0,10818294 0,1429183 ! phototransduction GO:0007602 25 21 0,000 0,10818294 0,14283626 ! dendrite development GO:0016358 35 21 0,000 0,10818294 0,14275431 ! visual behavior GO:0007632 39 21 0,000 0,10818294 0,14267246 ! ovarian follicle development GO:0001541 30 21 0,000 0,10818294 0,14259069 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,10818294 0,14250903 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,10818294 0,14242745 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,10818294 0,14234597 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,10818294 0,14226459 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,10818294 0,14218329 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,10818294 0,14210209 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,10818294 0,14202098 ! fatty acid transport GO:0015908 30 21 0,000 0,10818294 0,14193997 ! immunoglobulin production GO:0002377 33 21 0,000 0,10818294 0,14185904 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,10818294 0,14177821 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,10818294 0,14169747 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,10818294 0,14161683 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,10818294 0,14153627 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,10818294 0,14145581 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,10818294 0,14137543 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,10818294 0,14129515 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,10818294 0,14121496 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,10818294 0,14113486 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,10818294 0,14105485 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,10818294 0,14097494 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,10818294 0,14089511 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,10818294 0,14081537 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,10818294 0,14073573 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,11303505 0,14696473 ! viral genome replication GO:0019079 29 22 0,000 0,11303505 0,1468817 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,11303505 0,14679876 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,11303505 0,14671592 ! leukocyte adhesion GO:0007159 38 22 0,000 0,11303505 0,14663317 ! molting cycle process GO:0022404 40 22 0,000 0,11303505 0,14655051 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 0,000 0,11303505 0,14646795 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,11303505 0,14638548 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,11303505 0,1463031 ! vasculogenesis GO:0001570 33 22 0,000 0,11303505 0,14622081 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,11303505 0,14613862 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,11303505 0,14605652 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,11303505 0,14597451 ! lysosome organization GO:0007040 37 22 0,000 0,11303505 0,1458926 ! ureteric bud development GO:0001657 32 22 0,000 0,11303505 0,14581077 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,11303505 0,14572904 ! regulation of behavior GO:0050795 38 22 0,000 0,11303505 0,1456474 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,11303505 0,14556585 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,11303505 0,14548439 ! membrane depolarization GO:0051899 35 22 0,000 0,11303505 0,14540302 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,11303505 0,14532175 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,11303505 0,14524056 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,11303505 0,14515947 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,11303505 0,14507846 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,11303505 0,14499755 ! blastocyst development GO:0001824 37 22 0,000 0,11303505 0,14491673 ! neural tube closure GO:0001843 33 22 0,000 0,11303505 0,14483599 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,11303505 0,14475535 ! neuron fate commitment GO:0048663 32 23 0,000 0,11786103 0,15085162 ! embryonic pattern specification GO:0009880 31 23 0,000 0,11786103 0,15076772 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,11786103 0,15068392 ! myelination GO:0042552 35 23 0,000 0,11786103 0,1506002 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,11786103 0,15051658 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,11786103 0,15043306 ! vesicle targeting GO:0006903 32 23 0,000 0,11786103 0,15034962 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,11786103 0,15026628 ! osteoblast differentiation GO:0001649 40 23 0,000 0,11786103 0,15018303 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,11786103 0,15009987 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,11786103 0,15001681 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,11786103 0,14993383 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,11786103 0,14985095 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,11786103 0,14976816 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,11786103 0,14968546 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,11786103 0,14960285 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,11786103 0,14952033 ! cell fate determination GO:0001709 45 23 0,000 0,11786103 0,14943791 ! pentose metabolic process GO:0019321 31 23 0,000 0,11786103 0,14935557 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,11786103 0,14927333 ! spermatid development GO:0007286 33 23 0,000 0,11786103 0,14919118 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,11786103 0,14910911 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,11786103 0,14902714 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,11786103 0,14894526 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,11786103 0,14886346 ! telomere organization GO:0032200 32 23 0,000 0,11786103 0,14878176 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,11786103 0,14870015 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,11786103 0,14861862 ! regulation of amine transport GO:0051952 38 23 0,000 0,11786103 0,14853719 ! initiation of viral infection GO:0019059 42 24 0,000 0,12266103 0,15450184 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,12266103 0,15441728 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,12266103 0,15433281 ! superoxide metabolic process GO:0006801 32 24 0,000 0,12266103 0,15424842 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,12266103 0,15416414 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,12266103 0,15407994 ! fat cell differentiation GO:0045444 37 24 0,000 0,12266103 0,15399583 ! sperm motility GO:0030317 27 24 0,000 0,12266103 0,15391182 ! vacuole organization GO:0007033 39 24 0,000 0,12266103 0,1538279 ! receptor metabolic process GO:0043112 37 24 0,000 0,12266103 0,15374407 ! neural crest cell development GO:0014032 39 24 0,000 0,12266103 0,15366033 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,12266103 0,15357668 ! primary neural tube formation GO:0014020 35 24 0,000 0,12266103 0,15349313 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,12266103 0,15340966 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,12266103 0,15332629 ! glutathione metabolic process GO:0006749 29 24 0,000 0,12266103 0,153243 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,12266103 0,15315981 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,12266103 0,15307671 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,12266103 0,15299369 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,12743518 0,15886229 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,12743518 0,15877623 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,12743518 0,15869027 ! peptide transport GO:0015833 43 25 0,000 0,12743518 0,1586044 ! male gonad development GO:0008584 33 25 0,000 0,12743518 0,15851862 ! iron ion homeostasis GO:0055072 39 25 0,000 0,12743518 0,15843293 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,12743518 0,15834734 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,12743518 0,15826184 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,12743518 0,15817643 ! phospholipid transport GO:0015914 35 25 0,000 0,12743518 0,15809111 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,12743518 0,15800589 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,12743518 0,15792076 ! detection of light stimulus GO:0009583 30 25 0,000 0,12743518 0,15783572 ! leukocyte proliferation GO:0070661 39 25 0,000 0,12743518 0,15775077 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,12743518 0,15766591 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,13218363 0,16345288 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,13218363 0,16336505 ! translational initiation GO:0006413 43 26 0,000 0,13218363 0,16327731 ! circadian rhythm GO:0007623 42 26 0,000 0,13218363 0,16318967 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,13218363 0,16310212 ! post-embryonic development GO:0009791 42 26 0,000 0,13218363 0,16301467 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,13218363 0,16292731 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,13218363 0,16284004 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,13218363 0,16275287 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,13218363 0,16266579 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,13218363 0,1625788 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,13218363 0,16249191 ! regulation of coagulation GO:0050818 39 26 0,000 0,13218363 0,1624051 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,13690651 0,16811798 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,13690651 0,16802827 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,13690651 0,16793865 ! membrane docking GO:0022406 39 27 0,000 0,13690651 0,16784913 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,13690651 0,16775971 ! catechol metabolic process GO:0009712 43 27 0,000 0,13690651 0,16767038 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,13690651 0,16758115 ! acute-phase response GO:0006953 42 27 0,000 0,13690651 0,16749201 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,13690651 0,16740296 ! myofibril assembly GO:0030239 36 27 0,000 0,13690651 0,16731401 GO:0055002|striated muscle cell development, ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,13690651 0,16722516 ! natural killer cell activation GO:0030101 35 27 0,000 0,13690651 0,1671364 ! lipid oxidation GO:0034440 38 27 0,000 0,13690651 0,16704773 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,13690651 0,16695916 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,13690651 0,16687068 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,13690651 0,1667823 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,13690651 0,166694 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,13690651 0,16660581 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,13690651 0,1665177 ! gene silencing GO:0016458 41 27 0,000 0,13690651 0,16642969 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,14160395 0,17204918 ! phenol metabolic process GO:0018958 44 28 0,000 0,14160395 0,17195834 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,14160395 0,1718676 ! cell junction assembly GO:0034329 56 28 0,000 0,14160395 0,17177695 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,14160395 0,1716864 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,14160395 0,17159594 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,14160395 0,17150558 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,14160395 0,17141531 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,14160395 0,17132514 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,14160395 0,17123507 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,14160395 0,17114508 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,14160395 0,1710552 ! mesoderm formation GO:0001707 46 28 0,000 0,14160395 0,1709654 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,14160395 0,17087571 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,14160395 0,1707861 ! ensheathment of neurons GO:0007272 43 28 0,000 0,14160395 0,17069659 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,14160395 0,17060717 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,14160395 0,17051785 ! neural tube formation GO:0001841 41 28 0,000 0,14160395 0,17042862 ! placenta development GO:0001890 37 28 0,000 0,14160395 0,17033948 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,1462761 0,17586776 ! regulation of innate immune response GO:0045088 38 29 0,000 0,1462761 0,17577588 ! ovulation cycle process GO:0022602 41 29 0,000 0,1462761 0,17568409 ! protein targeting to membrane GO:0006612 53 29 0,000 0,1462761 0,1755924 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,1462761 0,1755008 ! mismatch repair GO:0006298 34 29 0,000 0,1462761 0,1754093 ! muscle cell development GO:0055001 38 29 0,000 0,1462761 0,17531789 ! formation of primary germ layer GO:0001704 48 29 0,000 0,1462761 0,17522658 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,1462761 0,17513536 ! eye morphogenesis GO:0048592 51 29 0,000 0,1462761 0,17504424 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,1462761 0,17495321 ! tissue homeostasis GO:0001894 42 29 0,000 0,1462761 0,17486228 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,15092308 0,18032368 ! collagen metabolic process GO:0032963 40 30 0,000 0,15092308 0,18023006 ! organic anion transport GO:0015711 51 30 0,000 0,15092308 0,18013653 ! cholesterol transport GO:0030301 46 30 0,000 0,15092308 0,18004309 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,15092308 0,17994976 ! spliceosome assembly GO:0000245 49 30 0,000 0,15092308 0,17985652 ! spindle organization GO:0007051 37 30 0,000 0,15092308 0,17976338 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,15092308 0,17967033 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,15092308 0,17957739 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,15092308 0,17948453 ! ceramide metabolic process GO:0006672 43 30 0,000 0,15092308 0,17939178 ! ovulation cycle GO:0042698 43 30 0,000 0,15092308 0,17929912 ! hindbrain development GO:0030902 45 30 0,000 0,15092308 0,17920655 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,15092308 0,17911408 ! adult locomotory behavior GO:0008344 47 30 0,000 0,15092308 0,17902171 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,15092308 0,17892943 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,15092308 0,17883724 ! response to heat GO:0009408 41 30 0,000 0,15092308 0,17874515 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,15092308 0,17865316 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,15092308 0,17856126 ! negative regulation of secretion GO:0051048 49 31 0,000 0,15554503 0,183935 ! mammary gland development GO:0030879 57 31 0,000 0,15554503 0,18384048 ! glial cell differentiation GO:0010001 55 31 0,000 0,15554503 0,18374606 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,15554503 0,18365173 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,15554503 0,1835575 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,15554503 0,18346337 ! odontogenesis GO:0042476 50 31 0,000 0,15554503 0,18336934 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,15554503 0,1832754 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,15554503 0,18318155 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,15554503 0,18308781 ! metanephros development GO:0001656 58 31 0,000 0,15554503 0,18299416 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,15554503 0,1829006 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,15554503 0,18280714 ! cell fate specification GO:0001708 37 31 0,000 0,15554503 0,18271378 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,15554503 0,18262051 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,15554503 0,18252733 ! RNA modification GO:0009451 40 31 0,000 0,15554503 0,18243426 ! regulation of muscle development GO:0048634 48 32 0,000 0,16014209 0,18773028 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,16014209 0,18763464 ! meiosis I GO:0007127 52 32 0,000 0,16014209 0,18753911 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,16014209 0,18744367 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,16014209 0,18734832 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,16014209 0,18725308 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 0,000 0,16014209 0,18715793 ! regulation of protein stability GO:0031647 48 32 0,000 0,16014209 0,18706288 ! cytokine production GO:0001816 44 32 0,000 0,16014209 0,18696792 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,16014209 0,18687306 ! vesicle localization GO:0051648 47 32 0,000 0,16014209 0,1867783 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,16471438 0,19201372 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,16471438 0,19191645 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,16471438 0,19181928 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,16471438 0,19172221 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,16471438 0,19162523 ! sister chromatid segregation GO:0000819 46 33 0,000 0,16471438 0,19152835 ! ear morphogenesis GO:0042471 42 33 0,000 0,16471438 0,19143157 ! actomyosin structure organization GO:0031032 43 33 0,000 0,16471438 0,19133489 ! cell junction organization GO:0034330 63 33 0,000 0,16471438 0,1912383 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,16471438 0,19114182 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,16471438 0,19104542 ! nucleus organization GO:0006997 49 33 0,000 0,16471438 0,19094913 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,16471438 0,19085294 ! female gonad development GO:0008585 49 33 0,000 0,16471438 0,19075684 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,16471438 0,19066083 ! positive regulation of cell development GO:0010720 54 33 0,000 0,16471438 0,19056493 ! lipid homeostasis GO:0055088 55 33 0,000 0,16471438 0,19046912 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,16471438 0,19037341 ! regulation of proteolysis GO:0030162 50 33 0,000 0,16471438 0,19027779 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,16471438 0,19018227 ! cytokinesis GO:0000910 52 33 0,000 0,16471438 0,19008684 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,16926204 0,19523706 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,16926204 0,1951392 ! feeding behavior GO:0007631 45 34 0,000 0,16926204 0,19504143 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,16926204 0,19494376 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,16926204 0,19484619 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,16926204 0,19474872 ! female gamete generation GO:0007292 43 34 0,000 0,16926204 0,19465135 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,16926204 0,19455407 ! polyol metabolic process GO:0019751 44 34 0,000 0,16926204 0,19445689 ! aerobic respiration GO:0009060 47 34 0,000 0,16926204 0,19435981 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,16926204 0,19426282 ! embryonic organ development GO:0048568 45 34 0,000 0,16926204 0,19416593 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,16926204 0,19406914 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,1737852 0,19915594 ! Notch signaling pathway GO:0007219 56 35 0,000 0,1737852 0,19905676 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,1737852 0,19895767 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,1737852 0,19885869 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,1737852 0,1987598 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,1737852 0,19866102 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,1737852 0,19856233 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,1737852 0,19846374 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,1737852 0,19836524 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,1737852 0,19826685 ! glycogen metabolic process GO:0005977 48 35 0,000 0,1737852 0,19816855 ! pigment metabolic process GO:0042440 61 35 0,000 0,1737852 0,19807035 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,17828399 0,20309717 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,17828399 0,20299663 ! negative regulation of binding GO:0051100 58 36 0,000 0,17828399 0,20289618 ! organic ether metabolic process GO:0018904 46 36 0,000 0,17828399 0,20279584 ! tissue remodeling GO:0048771 62 36 0,000 0,17828399 0,20269559 ! neural tube development GO:0021915 50 36 0,000 0,17828399 0,20259545 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,17828399 0,2024954 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,17828399 0,20239545 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,17828399 0,2022956 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,17828399 0,20219585 ! glucan metabolic process GO:0044042 49 36 0,000 0,17828399 0,2020962 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,18275855 0,20706633 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,18275855 0,20696438 ! learning GO:0007612 67 37 0,000 0,18275855 0,20686253 ! ion transmembrane transport GO:0034220 56 37 0,000 0,18275855 0,20676077 ! regulation of protein secretion GO:0050708 51 37 0,000 0,18275855 0,20665912 ! amino acid activation GO:0043038 52 37 0,000 0,18275855 0,20655757 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,18275855 0,20645612 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,18720899 0,21137981 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,18720899 0,21127609 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,18720899 0,21117247 ! phagocytosis GO:0006909 60 38 0,000 0,18720899 0,21106895 ! mesenchymal cell development GO:0014031 64 38 0,000 0,18720899 0,21096554 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 0,000 0,18720899 0,21086223 ! maintenance of location in cell GO:0051651 69 38 0,000 0,18720899 0,21075901 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,19163544 0,21563675 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,19163544 0,21553131 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,19163544 0,21542596 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,19163544 0,21532072 ! male sex differentiation GO:0046661 53 39 0,000 0,19163544 0,21521559 ! chromatin remodeling GO:0006338 68 39 0,000 0,19163544 0,21511055 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,19163544 0,21500562 ! JNK cascade GO:0007254 54 39 0,000 0,19163544 0,21490079 ! developmental growth GO:0048589 62 39 0,000 0,19163544 0,21479606 ! synapse organization GO:0050808 55 39 0,000 0,19163544 0,21469144 ! response to calcium ion GO:0051592 58 40 0,000 0,19603805 0,2195168 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,19603805 0,21940998 ! regulation of tube size GO:0035150 60 40 0,000 0,19603805 0,21930327 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,19603805 0,21919665 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,19603805 0,21909014 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,19603805 0,21898374 ! peptide metabolic process GO:0006518 56 40 0,000 0,19603805 0,21887743 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,19603805 0,21877123 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,19603805 0,21866514 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,20041693 0,22344107 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,20041693 0,22333282 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,20041693 0,22322466 ! glucose transport GO:0015758 52 41 0,000 0,20041693 0,22311662 ! endosome transport GO:0016197 71 41 0,000 0,20041693 0,22300868 ! striated muscle contraction GO:0006941 62 41 0,000 0,20041693 0,22290084 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,20041693 0,2227931 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,2047722 0,22752467 ! cellular component disassembly GO:0022411 64 42 0,000 0,2047722 0,22741481 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,2047722 0,22730505 ! hexose transport GO:0008645 54 42 0,000 0,2047722 0,2271954 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,2047722 0,22708586 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,2047722 0,22697642 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,2047722 0,22686709 ! excretion GO:0007588 63 42 0,000 0,2047722 0,22675786 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,2047722 0,22664873 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,2047722 0,22653972 ! regulation of cell shape GO:0008360 78 42 0,000 0,2047722 0,2264308 ! leukocyte migration GO:0050900 60 43 0,000 0,20910401 0,23110967 ! neuromuscular process GO:0050905 79 43 0,000 0,20910401 0,23099866 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,20910401 0,23088777 ! tRNA processing GO:0008033 49 43 0,000 0,20910401 0,23077698 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,20910401 0,23066629 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,21341246 0,23530616 ! glycolysis GO:0006096 53 44 0,000 0,21341246 0,23519342 ! regulation of action potential GO:0001508 71 44 0,000 0,21341246 0,23508078 ! regulation of ion transport GO:0043269 57 44 0,000 0,21341246 0,23496824 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,21341246 0,23485582 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,21341246 0,2347435 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,21341246 0,23463129 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,21341246 0,23451919 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,21341246 0,23440719 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,21341246 0,2342953 ! positive regulation of defense response GO:0031349 59 45 0,000 0,21769769 0,23888582 ! regulation of translational initiation GO:0006446 64 45 0,000 0,21769769 0,23877191 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,21769769 0,2386581 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,21769769 0,23854439 ! cell maturation GO:0048469 60 45 0,000 0,21769769 0,2384308 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,22195982 0,24298314 ! cell redox homeostasis GO:0045454 63 46 0,000 0,22195982 0,24286754 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,22195982 0,24275206 ! regulation of ossification GO:0030278 71 46 0,000 0,22195982 0,24263668 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,22619897 0,24715327 ! viral infectious cycle GO:0019058 71 47 0,000 0,22619897 0,24703591 ! endocrine system development GO:0035270 83 47 0,000 0,22619897 0,24691866 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,22619897 0,24680153 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,22619897 0,24668451 ! chloride transport GO:0006821 67 48 0,000 0,23041526 0,25116355 ! response to temperature stimulus GO:0009266 62 48 0,000 0,23041526 0,25104458 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,23041526 0,25092571 ! gastrulation GO:0007369 73 48 0,000 0,23041526 0,25080696 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,23041526 0,25068832 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,23041526 0,25056979 ! regulation of endocytosis GO:0030100 63 48 0,000 0,23041526 0,25045137 ! nuclear export GO:0051168 69 48 0,000 0,23041526 0,25033307 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,23041526 0,25021487 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,23460882 0,25464856 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,23460882 0,25452844 ! sensory perception of smell GO:0007608 61 49 0,000 0,23460882 0,25440844 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,23460882 0,25428854 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,23460882 0,25416877 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,23460882 0,2540491 ! germ cell development GO:0007281 68 49 0,000 0,23460882 0,25392955 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,23460882 0,25381011 ! cartilage development GO:0051216 70 49 0,000 0,23460882 0,25369078 ! maintenance of location GO:0051235 84 49 0,000 0,23460882 0,25357157 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,23877977 0,25795842 ! membrane fusion GO:0006944 80 50 0,000 0,23877977 0,25783731 ! proton transport GO:0015992 75 50 0,000 0,23877977 0,25771632 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,23877977 0,25759544 ! positive regulation of secretion GO:0051047 71 51 0,000 0,24292823 0,26194793 ! hydrogen transport GO:0006818 77 51 0,000 0,24292823 0,26182518 ! muscle fiber development GO:0048747 74 51 0,000 0,24292823 0,26170254 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,24292823 0,26158002 ! adult behavior GO:0030534 80 51 0,000 0,24292823 0,26145762 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,24292823 0,26133533 ! transition metal ion transport GO:0000041 74 52 0,000 0,24705432 0,2656498 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,24705432 0,26552567 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,25115815 0,26981025 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,25115815 0,26968429 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,25115815 0,26955845 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,25115815 0,26943272 ! kidney development GO:0001822 90 53 0,000 0,25115815 0,26930711 ! single fertilization GO:0007338 59 53 0,000 0,25115815 0,26918162 ! amino acid transport GO:0006865 84 54 0,000 0,25523985 0,27342881 ! glucose catabolic process GO:0006007 66 54 0,000 0,25523985 0,27330152 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,25523985 0,27317434 ! DNA catabolic process GO:0006308 67 54 0,000 0,25523985 0,27304728 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,25523985 0,27292035 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,25523985 0,27279352 ! exocytosis GO:0006887 74 55 0,000 0,25929954 0,27700369 ! mesoderm development GO:0007498 76 55 0,000 0,25929954 0,27687509 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,25929954 0,27674661 ! carbohydrate transport GO:0008643 74 57 0,000 0,26735334 0,28520996 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,26735334 0,28507773 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,26735334 0,28494563 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,26735334 0,28481365 ! camera-type eye development GO:0043010 88 57 0,000 0,26735334 0,28468179 ! secondary metabolic process GO:0019748 84 57 0,000 0,26735334 0,28455006 ! developmental maturation GO:0021700 75 57 0,000 0,26735334 0,28441844 ! gonad development GO:0008406 79 57 0,000 0,26735334 0,28428695 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,27134768 0,28840095 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,27134768 0,28826774 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,27532047 0,29235323 ! actin filament organization GO:0007015 95 59 0,000 0,27532047 0,29221832 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,27532047 0,29208353 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,27927183 0,29613887 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,27927183 0,29600241 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,27927183 0,29586606 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,27927183 0,29572984 ! regulation of heart contraction GO:0008016 91 60 0,000 0,27927183 0,29559375 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,27927183 0,29545778 ! fertilization GO:0009566 68 60 0,000 0,27927183 0,29532194 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,27927183 0,29518622 ! meiosis GO:0007126 96 61 0,000 0,28320188 0,29920272 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,28320188 0,29906534 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,28320188 0,29892809 ! urogenital system development GO:0001655 101 61 0,000 0,28320188 0,29879097 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,28320188 0,29865397 ! extracellular matrix organization GO:0030198 103 61 0,000 0,28320188 0,2985171 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,28320188 0,29838035 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,28320188 0,29824373 ! amine catabolic process GO:0009310 90 62 0,000 0,28711071 0,3022218 ! neurotransmitter transport GO:0006836 81 62 0,000 0,28711071 0,30208355 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,28711071 0,30194542 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,28711071 0,30180742 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,28711071 0,30166955 ! meiotic cell cycle GO:0051321 97 62 0,000 0,28711071 0,3015318 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,29099845 0,30547533 ! appendage morphogenesis GO:0035107 93 64 0,000 0,29486522 0,30939325 GO:0035108|limb morphogenesis, ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,29486522 0,30925217 ! hexose catabolic process GO:0019320 82 64 0,000 0,29486522 0,30911121 ! adaptive immune response GO:0002250 94 64 0,000 0,29486522 0,30897039 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,29871111 0,31285772 ! appendage development GO:0048736 94 65 0,000 0,29871111 0,31271532 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,29871111 0,31257305 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,29871111 0,3124309 ! defense response to bacterium GO:0042742 73 65 0,000 0,29871111 0,31228889 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,29871111 0,31214701 ! activation of immune response GO:0002253 83 65 0,000 0,29871111 0,31200525 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,30253625 0,31585718 ! antigen processing and presentation GO:0019882 96 66 0,000 0,30253625 0,31571387 ! axon guidance GO:0007411 99 66 0,000 0,30253625 0,31557069 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,30253625 0,31542764 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,30634074 0,31924953 ! acute inflammatory response GO:0002526 92 68 0,000 0,3101247 0,32304657 ! learning or memory GO:0007611 123 68 0,000 0,3101247 0,32290032 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,3101247 0,32275422 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,3101247 0,32260824 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,3101247 0,32246239 ! rhythmic process GO:0048511 105 68 0,000 0,3101247 0,32231668 ! inorganic anion transport GO:0015698 93 68 0,000 0,3101247 0,3221711 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,31388824 0,32593361 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,31388824 0,32578653 ! humoral immune response GO:0006959 86 70 0,000 0,31763145 0,32952293 ! eye development GO:0001654 111 70 0,000 0,31763145 0,32937436 ! amine transport GO:0015837 101 70 0,000 0,31763145 0,32922593 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,32135446 0,3329348 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,32135446 0,3327849 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,32135446 0,33263513 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,32135446 0,3324855 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,32505737 0,33616544 ! negative regulation of transport GO:0051051 116 73 0,000 0,32874028 0,33982141 ! regulation of blood pressure GO:0008217 107 73 0,000 0,32874028 0,33966875 ! tube morphogenesis GO:0035239 118 73 0,000 0,32874028 0,33951623 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,32874028 0,33936385 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,33240331 0,3429913 ! digestion GO:0007586 97 74 0,000 0,33240331 0,3428375 ! blood coagulation GO:0007596 116 75 0,000 0,33604656 0,34643975 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 0,000 0,33604656 0,34628454 ! regulation of ligase activity GO:0051340 114 75 0,000 0,33604656 0,34612946 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,33604656 0,34597452 ! amine biosynthetic process GO:0009309 97 76 0,000 0,33967014 0,34954869 ! tRNA metabolic process GO:0006399 95 76 0,000 0,33967014 0,34939236 ! response to unfolded protein GO:0006986 99 76 0,000 0,33967014 0,34923617 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,33967014 0,34908012 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,34327414 0,35262641 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,34327414 0,35246899 ! gland development GO:0048732 148 77 0,000 0,34327414 0,3523117 ! sex differentiation GO:0007548 105 77 0,000 0,34327414 0,35215456 ! protein ubiquitination GO:0016567 125 77 0,000 0,34327414 0,35199756 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,34327414 0,3518407 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,34327414 0,35168398 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,34685868 0,35519812 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,35042387 0,35868932 ! cellular respiration GO:0045333 107 79 0,000 0,35042387 0,35852976 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,35042387 0,35837034 ! regulation of lyase activity GO:0051339 133 79 0,000 0,35042387 0,35821106 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,35042387 0,35805193 ! chromatin assembly GO:0031497 102 80 0,000 0,35396979 0,36151444 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,35396979 0,36135398 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,35396979 0,36119366 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,35396979 0,36103349 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,35749656 0,36446901 ! hemostasis GO:0007599 125 81 0,000 0,35749656 0,36430753 ! response to protein stimulus GO:0051789 111 81 0,000 0,35749656 0,36414619 ! regulation of neurological system process GO:0031644 122 81 0,000 0,35749656 0,36398499 ! vitamin metabolic process GO:0006766 103 81 0,000 0,35749656 0,36382393 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,36449305 0,37078019 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,36449305 0,37061628 ! regulation of cell adhesion GO:0030155 159 83 0,000 0,36449305 0,3704525 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,36796297 0,37381397 ! sterol metabolic process GO:0016125 120 84 0,000 0,36796297 0,37364893 ! regulation of membrane potential GO:0042391 128 85 0,000 0,37141415 0,376987 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,37141415 0,3768207 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,37484667 0,38013551 ! nucleosome organization GO:0034728 114 87 0,000 0,37826065 0,3834286 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,37826065 0,38325969 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,37826065 0,38309093 ! female pregnancy GO:0007565 130 87 0,000 0,37826065 0,38292231 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,37826065 0,38275385 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,38165618 0,38601988 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,38165618 0,3858502 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,38165618 0,38568067 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,38165618 0,38551129 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,38503336 0,38875186 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,38503336 0,38858128 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,38839229 0,39179924 ! hormone metabolic process GO:0042445 121 90 0,000 0,38839229 0,39162747 ! ATP metabolic process GO:0046034 137 91 0,000 0,39173306 0,39482298 ! response to virus GO:0009615 122 91 0,000 0,39173306 0,39465004 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,39505578 0,39782324 ! positive regulation of immune response GO:0050778 121 92 0,000 0,39505578 0,39764914 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,39836053 0,40080019 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,39836053 0,40062493 ! response to oxidative stress GO:0006979 141 94 0,000 0,40164742 0,40375397 ! angiogenesis GO:0001525 149 95 0,000 0,40491655 0,40686241 ! carboxylic acid transport GO:0046942 147 95 0,000 0,40491655 0,40668474 GO:0015849|organic acid transport, ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,40816799 0,40977145 ! protein maturation GO:0051604 129 96 0,000 0,40816799 0,40959266 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,41140186 0,41265778 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,41781724 0,41891005 ! extracellular structure organization GO:0043062 156 99 0,000 0,41781724 0,41872751 ! regulation of translation GO:0006417 151 100 0,000 0,42099893 0,42173238 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,42099893 0,42154878 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,42099893 0,42136533 ! divalent metal ion transport GO:0070838 171 100 0,000 0,42099893 0,42118205 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,42099893 0,42099893