pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-VanDeVijver//out-0.3-01-0.03-300-VanDeVijver//go_data/1141-Desmedt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! nuclear migration GO:0007097 10 5 2,000 3,271E-07 7,524E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 3,271E-07 3,762E-04 GO:0031272|regulation of pseudopodium assembly, ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 4,732E-07 3,628E-04 ! macrophage differentiation GO:0030225 10 6 2,000 6,527E-07 3,753E-04 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 7,11E-07 3,27E-04 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 1,14E-06 4,369E-04 ! establishment of nucleus localization GO:0040023 13 7 2,000 1,14E-06 3,745E-04 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 1,819E-06 5,23E-04 ! protein oligomerization GO:0051259 100 65 4,000 2,191E-06 5,6E-04 ! nucleus localization GO:0051647 15 9 2,000 2,722E-06 6,262E-04 ! regulation of peptidase activity GO:0052547 106 72 4,000 3,648E-06 7,628E-04 ! regulation of cell projection assembly GO:0060491 20 10 2,000 3,88E-06 7,437E-04 ! establishment or maintenance of cell polarity GO:0007163 61 34 3,000 4,378E-06 7,746E-04 ! filopodium assembly GO:0046847 19 11 2,000 5,323E-06 8,745E-04 ! microspike assembly GO:0030035 23 12 2,000 7,081E-06 1,086E-03 ! response to UV GO:0009411 75 46 3,000 1,496E-05 2,151E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,163E-05 2,927E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 2,163E-05 2,764E-03 ! regulation of protein complex assembly GO:0043254 81 54 3,000 2,844E-05 3,443E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 3,069E-05 3,529E-03 ! regulation of lipid metabolic process GO:0019216 84 56 3,000 3,287E-05 3,6E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 3,527E-05 3,687E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 3,779E-05 3,779E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 4,192E-05 4,018E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 4,192E-05 3,857E-03 ! negative regulation of transferase activity GO:0051348 105 61 3,000 4,614E-05 4,082E-03 ! protein tetramerization GO:0051262 39 22 2,000 4,843E-05 4,126E-03 ! interaction with host GO:0051701 37 23 2,000 5,557E-05 4,564E-03 ! regulation of caspase activity GO:0043281 97 65 3,000 5,929E-05 4,702E-03 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 6,336E-05 4,857E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 6,336E-05 4,701E-03 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 6,68E-05 4,801E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 1,016E-04 7,082E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,016E-04 6,873E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 1,038E-04 6,821E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,038E-04 6,631E-03 ! positive regulation of vasoconstriction GO:0045907 9 5 1,000 1,038E-04 6,452E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 1,038E-04 6,282E-03 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 1,038E-04 6,121E-03 ! regulation of sensory perception GO:0051931 6 5 1,000 1,038E-04 5,968E-03 GO:0051930|regulation of sensory perception of pain, ! positive regulation of microtubule polymerization GO:0031116 9 5 1,000 1,038E-04 5,823E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 2,000 1,524E-04 8,347E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 1,554E-04 8,31E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,554E-04 8,121E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,554E-04 7,941E-03 ! ER overload response GO:0006983 7 6 1,000 1,554E-04 7,768E-03 ! positive regulation of insulin secretion GO:0032024 8 6 1,000 1,554E-04 7,603E-03 ! male sex determination GO:0030238 9 6 1,000 1,554E-04 7,445E-03 ! interaction with symbiont GO:0051702 8 6 1,000 1,554E-04 7,293E-03 ! gas homeostasis GO:0033483 11 6 1,000 1,554E-04 7,147E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,554E-04 7,007E-03 ! catecholamine transport GO:0051937 7 6 1,000 1,554E-04 6,872E-03 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 1,000 1,554E-04 6,742E-03 ! regulation of microtubule polymerization GO:0031113 11 6 1,000 1,554E-04 6,617E-03 ! carbohydrate homeostasis GO:0033500 39 33 2,000 1,673E-04 6,995E-03 GO:0042593|glucose homeostasis, ! cell cycle arrest GO:0007050 150 86 3,000 1,768E-04 7,259E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 1,768E-04 7,132E-03 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 1,83E-04 7,258E-03 ! skeletal muscle tissue development GO:0007519 123 87 3,000 1,848E-04 7,205E-03 GO:0060538|skeletal muscle organ development, ! interphase GO:0051325 159 88 3,000 1,932E-04 7,404E-03 ! protein homooligomerization GO:0051260 52 35 2,000 1,997E-04 7,531E-03 ! leukocyte differentiation GO:0002521 143 90 3,000 2,106E-04 7,814E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 2,171E-04 7,924E-03 ! negative regulation of JAK-STAT cascade GO:0046426 15 7 1,000 2,171E-04 7,8E-03 ! adrenal gland development GO:0030325 17 7 1,000 2,171E-04 7,68E-03 ! vesicle fusion GO:0006906 15 7 1,000 2,171E-04 7,564E-03 ! organ growth GO:0035265 11 7 1,000 2,171E-04 7,451E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 2,171E-04 7,342E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 2,171E-04 7,235E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 2,171E-04 7,132E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 2,171E-04 7,031E-03 ! response to tumor cell GO:0002347 12 7 1,000 2,171E-04 6,934E-03 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 1,000 2,171E-04 6,839E-03 ! in utero embryonic development GO:0001701 147 96 3,000 2,699E-04 8,389E-03 ! regulation of cellular component biogenesis GO:0044087 158 96 3,000 2,699E-04 8,277E-03 ! response to light stimulus GO:0009416 153 96 3,000 2,699E-04 8,168E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 2,763E-04 8,254E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 2,888E-04 8,516E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,888E-04 8,408E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 2,888E-04 8,303E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 2,888E-04 8,2E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 2,888E-04 8,1E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 2,98E-04 8,259E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 3,697E-04 0,01012312 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 3,697E-04 0,01000402 ! activation of caspase activity GO:0006919 65 43 2,000 3,697E-04 9,888E-03 ! response to insulin stimulus GO:0032868 63 43 2,000 3,697E-04 9,774E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 3,705E-04 9,684E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 3,705E-04 9,576E-03 ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 3,705E-04 9,469E-03 ! regulation of glycolysis GO:0006110 15 9 1,000 3,705E-04 9,365E-03 ! positive regulation of peptide secretion GO:0002793 15 9 1,000 3,705E-04 9,263E-03 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 3,705E-04 9,164E-03 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 1,000 3,705E-04 9,066E-03 ! positive regulation of protein polymerization GO:0032273 15 9 1,000 3,705E-04 8,971E-03 ! localization within membrane GO:0051668 15 9 1,000 3,705E-04 8,877E-03 ! regulation of cell projection organization GO:0031344 83 44 2,000 3,959E-04 9,386E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 4,231E-04 9,931E-03 ! regulation of B cell proliferation GO:0030888 15 10 1,000 4,622E-04 0,01073793 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 4,622E-04 0,01063055 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 4,622E-04 0,0105253 ! response to X-ray GO:0010165 16 10 1,000 4,622E-04 0,01042211 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 4,622E-04 0,01032093 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 4,622E-04 0,01022169 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 4,622E-04 0,01012434 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of caspase activity GO:0043280 72 48 2,000 5,122E-04 0,01111397 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 65 48 2,000 5,122E-04 0,01101011 ! regulation of DNA replication GO:0006275 75 48 2,000 5,122E-04 0,01090816 ! virus-host interaction GO:0019048 17 11 1,000 5,637E-04 0,01189513 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 5,637E-04 0,01178699 ! regulation of intracellular pH GO:0051453 17 11 1,000 5,637E-04 0,0116808 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 6,125E-04 0,01257737 ! positive regulation of cell migration GO:0030335 92 51 2,000 6,125E-04 0,01246606 ! establishment of organelle localization GO:0051656 85 52 2,000 6,485E-04 0,01308302 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 6,751E-04 0,0135011 ! monoamine transport GO:0015844 13 12 1,000 6,751E-04 0,01338471 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 6,751E-04 0,01327031 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 6,751E-04 0,01315785 ! gland morphogenesis GO:0022612 23 12 1,000 6,751E-04 0,01304728 ! peptidyl-lysine modification GO:0018205 18 12 1,000 6,751E-04 0,01293855 ! response to gamma radiation GO:0010332 20 12 1,000 6,751E-04 0,01283162 ! cell projection assembly GO:0030031 76 53 2,000 6,858E-04 0,01292877 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 7,961E-04 0,01488684 ! positive regulation of protein complex assembly GO:0031334 19 13 1,000 7,961E-04 0,01476678 ! lipid localization GO:0010876 24 13 1,000 7,961E-04 0,01464865 GO:0019915|lipid storage, ! organelle fusion GO:0048284 28 13 1,000 7,961E-04 0,01453239 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 7,961E-04 0,01441796 ! regulation of cellular pH GO:0030641 20 13 1,000 7,961E-04 0,01430532 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 7,961E-04 0,01419443 ! positive regulation of cell motion GO:0051272 99 56 2,000 8,059E-04 0,01425816 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 8,487E-04 0,01490099 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 9,269E-04 0,01614993 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 9,269E-04 0,0160285 ! startle response GO:0001964 21 14 1,000 9,269E-04 0,01590889 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 9,269E-04 0,01579104 ! cellular response to starvation GO:0009267 21 14 1,000 9,269E-04 0,01567493 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 9,269E-04 0,01556052 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 9,269E-04 0,01544776 ! G1/S transition checkpoint GO:0031575 33 14 1,000 9,269E-04 0,01533663 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 9,269E-04 0,01522708 ! cell killing GO:0001906 20 14 1,000 9,269E-04 0,01511909 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 9,269E-04 0,01501261 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 9,269E-04 0,01490763 ! myeloid cell differentiation GO:0030099 85 59 2,000 9,386E-04 0,01499169 ! lipid phosphorylation GO:0046834 23 15 1,000 1,067E-03 0,01692836 ! myoblast differentiation GO:0045445 27 15 1,000 1,067E-03 0,01681242 ! regulation of vasodilation GO:0042312 24 15 1,000 1,067E-03 0,01669805 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 1,067E-03 0,01658522 ! negative regulation of cell growth GO:0030308 106 62 2,000 1,084E-03 0,01673947 ! organelle localization GO:0051640 96 62 2,000 1,084E-03 0,01662788 ! negative regulation of cell size GO:0045792 108 64 2,000 1,189E-03 0,01811295 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 1,217E-03 0,01841713 ! protein amino acid acetylation GO:0006473 28 16 1,000 1,217E-03 0,01829676 ! complement activation, alternative pathway GO:0006957 16 16 1,000 1,217E-03 0,01817795 ! G1 phase GO:0051318 27 16 1,000 1,217E-03 0,01806067 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 1,217E-03 0,0179449 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 1,377E-03 0,02016576 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 1,377E-03 0,02003812 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 1,000 1,377E-03 0,0199121 ! positive regulation of DNA replication GO:0045740 29 18 1,000 1,545E-03 0,02221456 ! pancreas development GO:0031016 26 18 1,000 1,545E-03 0,02207658 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 1,545E-03 0,02194031 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 1,545E-03 0,02180571 ! somitogenesis GO:0001756 24 18 1,000 1,545E-03 0,02167274 ! cellular response to nutrient levels GO:0031669 27 18 1,000 1,545E-03 0,02154139 ! hormone transport GO:0009914 27 18 1,000 1,545E-03 0,02141163 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 1,545E-03 0,02128341 ! response to hypoxia GO:0001666 132 72 2,000 1,671E-03 0,02287876 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 1,724E-03 0,02345671 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 1,724E-03 0,02331872 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 1,724E-03 0,02318236 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 1,724E-03 0,02304758 ! response to starvation GO:0042594 30 19 1,000 1,724E-03 0,02291435 ! sex determination GO:0007530 29 19 1,000 1,724E-03 0,02278266 ! cytolysis GO:0019835 20 19 1,000 1,724E-03 0,02265248 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 1,724E-03 0,02252377 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,724E-03 0,02239652 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 1,724E-03 0,02227069 ! response to oxygen levels GO:0070482 137 74 2,000 1,808E-03 0,02323207 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 1,808E-03 0,023103 ! negative regulation of growth GO:0045926 123 75 2,000 1,879E-03 0,02387766 ! positive regulation of B cell activation GO:0050871 31 20 1,000 1,911E-03 0,02415079 ! gland development GO:0048732 148 77 2,000 2,026E-03 0,02546657 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 2,108E-03 0,02634767 ! protein amino acid acylation GO:0043543 37 21 1,000 2,108E-03 0,02620525 ! vesicle docking GO:0048278 27 21 1,000 2,108E-03 0,02606436 ! cell aging GO:0007569 32 21 1,000 2,108E-03 0,02592498 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 2,108E-03 0,02578708 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 2,108E-03 0,02565064 ! regulation of insulin secretion GO:0050796 26 21 1,000 2,108E-03 0,02551564 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 1,000 2,108E-03 0,02538205 GO:0060415|muscle tissue morphogenesis, ! regulation of vasoconstriction GO:0019229 31 21 1,000 2,108E-03 0,02524985 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 2,314E-03 0,02757321 ! vasculogenesis GO:0001570 33 22 1,000 2,314E-03 0,02743108 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 2,314E-03 0,02729041 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 2,314E-03 0,02715117 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 2,314E-03 0,02701335 ! ureteric bud development GO:0001657 32 22 1,000 2,314E-03 0,02687692 ! membrane depolarization GO:0051899 35 22 1,000 2,314E-03 0,02674186 ! regulation of blood coagulation GO:0030193 34 22 1,000 2,314E-03 0,02660815 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 2,529E-03 0,02893672 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 2,529E-03 0,02879346 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 2,529E-03 0,02865162 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 2,529E-03 0,02851118 ! negative regulation of DNA replication GO:0008156 35 23 1,000 2,529E-03 0,0283721 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 2,529E-03 0,02823437 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 2,529E-03 0,02809797 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 2,686E-03 0,02970163 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 2,686E-03 0,02955952 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 2,753E-03 0,03015136 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 2,753E-03 0,03000846 ! fat cell differentiation GO:0045444 37 24 1,000 2,753E-03 0,02986691 ! mitochondrial membrane organization GO:0007006 39 24 1,000 2,753E-03 0,02972669 ! negative regulation of cell development GO:0010721 56 24 1,000 2,753E-03 0,02958778 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 2,753E-03 0,02945016 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 2,753E-03 0,02931382 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 2,753E-03 0,02917873 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 2,869E-03 0,03027272 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 2,986E-03 0,03136077 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 2,986E-03 0,03121822 ! regulation of peptide secretion GO:0002791 34 25 1,000 2,986E-03 0,03107696 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 2,986E-03 0,03093697 ! regulation of pH GO:0006885 36 26 1,000 3,228E-03 0,03329513 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 3,228E-03 0,0331465 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 3,228E-03 0,03299918 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 3,228E-03 0,03285316 ! regulation of coagulation GO:0050818 39 26 1,000 3,228E-03 0,03270844 ! cell fate commitment GO:0045165 141 92 2,000 3,361E-03 0,03390161 ! peptidyl-amino acid modification GO:0018193 147 93 2,000 3,465E-03 0,03479869 ! membrane docking GO:0022406 39 27 1,000 3,479E-03 0,0347916 ! catechol metabolic process GO:0009712 43 27 1,000 3,479E-03 0,03464099 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! response to ionizing radiation GO:0010212 47 27 1,000 3,479E-03 0,03449168 ! phenol metabolic process GO:0018958 44 28 1,000 3,739E-03 0,03690831 ! cholesterol homeostasis GO:0042632 46 28 1,000 3,739E-03 0,03675058 GO:0055092|sterol homeostasis, ! complement activation, classical pathway GO:0006958 36 28 1,000 3,739E-03 0,0365942 ! triglyceride metabolic process GO:0006641 34 28 1,000 3,739E-03 0,03643914 ! positive regulation of catabolic process GO:0009896 40 28 1,000 3,739E-03 0,03628539 ! regulation of B cell activation GO:0050864 42 28 1,000 3,739E-03 0,03613293 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 4,008E-03 0,03856646 ! cholesterol transport GO:0030301 46 30 1,000 4,285E-03 0,04106323 GO:0015918|sterol transport, ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 1,000 4,285E-03 0,04089285 ! adult locomotory behavior GO:0008344 47 30 1,000 4,285E-03 0,04072387 ! regulation of microtubule-based process GO:0032886 58 30 1,000 4,285E-03 0,04055628 ! DNA damage checkpoint GO:0000077 53 31 1,000 4,571E-03 0,04308558 ! mammary gland development GO:0030879 57 31 1,000 4,571E-03 0,04290973 ! segmentation GO:0035282 41 31 1,000 4,571E-03 0,0427353 ! metanephros development GO:0001656 58 31 1,000 4,571E-03 0,04256228 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 4,571E-03 0,04239066 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 4,865E-03 0,04494125 ! neutral lipid metabolic process GO:0006638 41 32 1,000 4,865E-03 0,04476148 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 4,865E-03 0,04458315 ! calcium-mediated signaling GO:0019722 50 32 1,000 4,865E-03 0,04440623 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 5,168E-03 0,0469862 ! lipid homeostasis GO:0055088 55 33 1,000 5,168E-03 0,04680122 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 5,168E-03 0,04661768 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 5,168E-03 0,04643558 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 5,48E-03 0,04904345 ! DNA integrity checkpoint GO:0031570 57 34 1,000 5,48E-03 0,04885336 ! glycerol ether metabolic process GO:0006662 44 34 1,000 5,48E-03 0,04866474 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 5,8E-03 0,05130851 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 5,8E-03 0,05111193 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 6,128E-03 0,0537997 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 1,000 6,128E-03 0,05359514 ! organic ether metabolic process GO:0018904 46 36 1,000 6,128E-03 0,05339212 ! tissue remodeling GO:0048771 62 36 1,000 6,128E-03 0,05319064 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 1,000 6,465E-03 0,0559021 GO:0006956|complement activation, ! gliogenesis GO:0042063 71 38 1,000 6,81E-03 0,05866442 ! mesenchymal cell development GO:0014031 64 38 1,000 6,81E-03 0,05844552 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! JNK cascade GO:0007254 54 39 1,000 7,163E-03 0,06124801 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 7,525E-03 0,06409918 ! T cell differentiation GO:0030217 65 40 1,000 7,525E-03 0,06386265 ! double-strand break repair GO:0006302 67 40 1,000 7,525E-03 0,06362786 ! B cell differentiation GO:0030183 62 40 1,000 7,525E-03 0,0633948 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 7,525E-03 0,06316343 ! positive regulation of protein transport GO:0051222 55 40 1,000 7,525E-03 0,06293374 ! positive regulation of DNA binding GO:0043388 57 41 1,000 7,894E-03 0,06578429 ! mitochondrial transport GO:0006839 60 42 1,000 8,272E-03 0,06868103 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 8,272E-03 0,06843398 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 8,272E-03 0,06818869 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 8,272E-03 0,06794516 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 8,272E-03 0,06770336 ! excretion GO:0007588 63 42 1,000 8,272E-03 0,06746328 ! positive regulation of binding GO:0051099 59 43 1,000 8,657E-03 0,07035759 ! neuromuscular process GO:0050905 79 43 1,000 8,657E-03 0,07010985 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 8,657E-03 0,06986385 ! vesicle organization GO:0016050 79 43 1,000 8,657E-03 0,06961957 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 8,657E-03 0,06937699 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 9,05E-03 0,07227776 ! positive regulation of cell cycle GO:0045787 77 45 1,000 9,452E-03 0,07522115 ! regulation of ossification GO:0030278 71 46 1,000 9,861E-03 0,07820631 ! histone modification GO:0016570 68 46 1,000 9,861E-03 0,07793756 ! endocrine system development GO:0035270 83 47 1,000 0,01027766 0,08095418 ! covalent chromatin modification GO:0016569 75 47 1,000 0,01027766 0,08067789 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,01027766 0,08040348 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,01027766 0,08013092 ! regulation of protein polymerization GO:0032271 71 47 1,000 0,01027766 0,07986021 ! regulation of muscle contraction GO:0006937 69 48 1,000 0,01070225 0,08287935 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,01070225 0,08260123 GO:0019724|B cell mediated immunity, ! regulation of intracellular transport GO:0032386 78 49 1,000 0,0111345 0,08564998 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,0111345 0,08536448 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,0111345 0,08508088 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,01157436 0,08814911 ! membrane fusion GO:0006944 80 50 1,000 0,01157436 0,08785819 ! lipid modification GO:0030258 73 50 1,000 0,01157436 0,08756918 ! positive regulation of growth GO:0045927 67 50 1,000 0,01157436 0,08728207 ! positive regulation of secretion GO:0051047 71 51 1,000 0,01202179 0,09035982 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,01202179 0,09006549 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,01202179 0,08977307 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,01202179 0,08948254 ! adult behavior GO:0030534 80 51 1,000 0,01202179 0,08919389 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01247672 0,09227155 ! aging GO:0007568 79 52 1,000 0,01247672 0,09197581 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,01247672 0,09168196 ! kidney development GO:0001822 90 53 1,000 0,01293911 0,0947769 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,01293911 0,09447602 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,0134089 0,09759644 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,0134089 0,09728856 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,0134089 0,09698263 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,0143705 0,10361176 ! viral reproductive process GO:0022415 87 58 1,000 0,0153611 0,11040793 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,0153611 0,11006398 ! protein maturation by peptide bond cleavage GO:0051605 76 58 1,000 0,0153611 0,10972217 ! activation of MAPK activity GO:0000187 84 59 1,000 0,01586716 0,11298594 ! lung development GO:0030324 94 59 1,000 0,01586716 0,11263722 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01619836 0,11463456 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01619836 0,11428292 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01619836 0,11393343 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01619836 0,11358607 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01619836 0,11324082 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01619836 0,11289767 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01619836 0,11255659 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01619836 0,11221756 ! sleep GO:0030431 11 5 0,000 0,01619836 0,11188057 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01619836 0,1115456 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01619836 0,11121263 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01619836 0,11088164 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01619836 0,11055261 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01619836 0,11022554 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01619836 0,10990039 ! tongue development GO:0043586 6 5 0,000 0,01619836 0,10957715 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01619836 0,10925581 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01619836 0,10893635 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01619836 0,10861875 ! cobalt ion transport GO:0006824 9 5 0,000 0,01619836 0,108303 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01619836 0,10798908 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01619836 0,10767697 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01619836 0,10736666 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01619836 0,10705814 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01619836 0,10675138 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01619836 0,10644637 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01619836 0,10614311 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01619836 0,10584157 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01619836 0,10554173 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01619836 0,10524359 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01619836 0,10494713 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01619836 0,10465233 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01619836 0,10435919 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01619836 0,10406768 ! malate metabolic process GO:0006108 7 5 0,000 0,01619836 0,1037778 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01619836 0,10348953 ! behavioral response to pain GO:0048266 7 5 0,000 0,01619836 0,10320286 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01619836 0,10291777 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01619836 0,10263425 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01619836 0,10235228 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01619836 0,10207187 ! mating behavior GO:0007617 6 5 0,000 0,01619836 0,10179298 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01619836 0,10151562 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01619836 0,10123976 ! rhythmic behavior GO:0007622 12 5 0,000 0,01619836 0,1009654 ! copulation GO:0007620 7 5 0,000 0,01619836 0,10069252 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01619836 0,10042111 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01619836 0,10015116 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01619836 0,09988266 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01619836 0,09961559 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01619836 0,09934995 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01619836 0,09908572 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01619836 0,09882289 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01619836 0,09856146 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01619836 0,0983014 ! response to protozoan GO:0001562 9 5 0,000 0,01619836 0,09804271 ! lymph vessel development GO:0001945 7 5 0,000 0,01619836 0,09778538 ! endochondral ossification GO:0001958 12 5 0,000 0,01619836 0,0975294 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01619836 0,09727476 ! parathyroid gland development GO:0060017 8 5 0,000 0,01619836 0,09702144 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01619836 0,09676943 ! anagen GO:0042640 6 5 0,000 0,01619836 0,09651873 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01619836 0,09626933 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01619836 0,09602121 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01619836 0,09577437 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01619836 0,0955288 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01619836 0,09528448 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01619836 0,09504141 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01619836 0,09479957 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01619836 0,09455896 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01619836 0,09431957 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01619836 0,09408139 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01619836 0,09384441 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01619836 0,09360862 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01619836 0,09337401 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01619836 0,09314058 ! ovulation GO:0030728 6 5 0,000 0,01619836 0,09290831 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01619836 0,09267719 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01619836 0,09244722 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01619836 0,09221839 ! response to pH GO:0009268 9 5 0,000 0,01619836 0,09199069 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01619836 0,09176412 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01619836 0,09153865 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01619836 0,09131429 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01619836 0,09109103 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01619836 0,09086886 ! polyol catabolic process GO:0046174 7 5 0,000 0,01619836 0,09064776 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01619836 0,09042775 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01619836 0,09020879 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01619836 0,0899909 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01619836 0,08977405 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01619836 0,08955825 ! urea metabolic process GO:0019627 6 5 0,000 0,01619836 0,08934348 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01619836 0,08912974 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01619836 0,08891702 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01619836 0,08870531 ! neutrophil activation GO:0042119 5 5 0,000 0,01619836 0,08849461 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01619836 0,08828491 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01619836 0,0880762 ! response to food GO:0032094 5 5 0,000 0,01619836 0,08786847 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01619836 0,08766172 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01619836 0,08745594 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01619836 0,08725113 ! forebrain neuron development GO:0021884 7 5 0,000 0,01619836 0,08704727 ! melanosome organization GO:0032438 7 5 0,000 0,01619836 0,08684436 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01619836 0,0866424 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01619836 0,08644137 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01619836 0,08624128 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01619836 0,0860421 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01619836 0,08584385 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01619836 0,08564651 ! nucleoside transport GO:0015858 6 5 0,000 0,01619836 0,08545007 ! nucleoside salvage GO:0043174 7 5 0,000 0,01619836 0,08525453 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01619836 0,08505989 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01619836 0,08486613 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01619836 0,08467325 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01619836 0,08448125 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01619836 0,08429012 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01619836 0,08409984 ! depyrimidination GO:0045008 8 5 0,000 0,01619836 0,08391043 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01619836 0,08372187 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01619836 0,08353415 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01619836 0,08334727 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01619836 0,08316123 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01619836 0,08297602 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01619836 0,08279162 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01619836 0,08260805 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01619836 0,08242529 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01619836 0,08224334 ! monocyte differentiation GO:0030224 8 5 0,000 0,01619836 0,08206218 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01619836 0,08188183 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01619836 0,08170226 ! centrosome duplication GO:0051298 5 5 0,000 0,01619836 0,08152348 ! response to UV-C GO:0010225 6 5 0,000 0,01619836 0,08134548 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01619836 0,08116826 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01619836 0,08099181 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01619836 0,08081612 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01619836 0,08064119 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01619836 0,08046702 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01619836 0,0802936 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01619836 0,08012093 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01619836 0,07994899 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01619836 0,0797778 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01619836 0,07960733 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01619836 0,07943759 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01619836 0,07926858 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01619836 0,07910028 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01619836 0,07893269 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01619836 0,07876582 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01619836 0,07859964 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01619836 0,07843417 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01619836 0,07826939 ! neural tube patterning GO:0021532 6 5 0,000 0,01619836 0,07810531 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01619836 0,07794191 ! histone demethylation GO:0016577 9 5 0,000 0,01619836 0,07777919 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01619836 0,07761715 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01619836 0,07745578 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01619836 0,07729509 ! enteric nervous system development GO:0048484 8 5 0,000 0,01619836 0,07713505 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01619836 0,07697568 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01619836 0,07681697 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01619836 0,07665891 ! transcription termination GO:0006353 8 5 0,000 0,01619836 0,0765015 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01619836 0,07634474 ! plasminogen activation GO:0031639 5 5 0,000 0,01619836 0,07618861 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01619836 0,07603312 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01619836 0,07587827 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01619836 0,07572405 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01619836 0,07557045 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01619836 0,07541747 ! apical protein localization GO:0045176 6 5 0,000 0,01619836 0,07526511 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01619836 0,07511337 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01619836 0,07496224 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01619836 0,07481171 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01619836 0,07466179 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01619836 0,07451246 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01619836 0,07436373 ! glial cell migration GO:0008347 10 5 0,000 0,01619836 0,0742156 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01619836 0,07406805 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01619836 0,07392109 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01619836 0,07377472 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01619836 0,07362892 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01619836 0,07348369 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01619836 0,07333904 ! neural plate development GO:0001840 6 5 0,000 0,01619836 0,07319495 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01619836 0,07305143 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01619836 0,07290848 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01619836 0,07276608 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01619836 0,07262423 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01619836 0,07248294 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01619836 0,0723422 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01619836 0,072202 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01619836 0,07206234 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01619836 0,07192323 ! spindle assembly GO:0051225 5 5 0,000 0,01619836 0,07178465 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01619836 0,0716466 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01619836 0,07150908 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01619836 0,07137209 ! organ regeneration GO:0031100 7 5 0,000 0,01619836 0,07123562 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01619836 0,07109968 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01619836 0,07096425 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01619836 0,07082934 GO:0055081|anion homeostasis, ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,01638031 0,07148901 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,01638031 0,07135362 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,01690051 0,07348048 ! urogenital system development GO:0001655 101 61 1,000 0,01690051 0,07334184 ! respiratory tube development GO:0030323 99 62 1,000 0,01742771 0,07548727 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,01742771 0,07534538 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,01796187 0,077509 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,01796187 0,07736385 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,01796187 0,07721924 ! viral reproduction GO:0016032 92 63 1,000 0,01796187 0,07707518 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01796187 0,07693165 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,01850292 0,07910171 ! respiratory system development GO:0060541 100 64 1,000 0,01850292 0,07895496 ! adaptive immune response GO:0002250 94 64 1,000 0,01850292 0,07880875 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 1,000 0,01905083 0,08099244 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,01905083 0,08084301 ! activation of immune response GO:0002253 83 65 1,000 0,01905083 0,08069413 ! tRNA transcription GO:0009304 11 6 0,000 0,01940696 0,08205149 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01940696 0,08190094 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01940696 0,08175093 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01940696 0,08160148 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01940696 0,08145257 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01940696 0,08130421 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01940696 0,08115638 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01940696 0,08100909 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01940696 0,08086234 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01940696 0,08071611 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01940696 0,08057042 ! prostate gland development GO:0030850 9 6 0,000 0,01940696 0,08042524 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01940696 0,08028059 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01940696 0,08013646 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01940696 0,07999285 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01940696 0,07984975 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01940696 0,07970716 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01940696 0,07956508 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01940696 0,07942351 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01940696 0,07928243 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01940696 0,07914186 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01940696 0,07900179 ! neuron adhesion GO:0007158 9 6 0,000 0,01940696 0,07886221 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01940696 0,07872312 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01940696 0,07858452 ! signal peptide processing GO:0006465 8 6 0,000 0,01940696 0,07844641 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01940696 0,07830879 ! mRNA stabilization GO:0048255 15 6 0,000 0,01940696 0,07817165 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01940696 0,07803498 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01940696 0,0778988 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01940696 0,07776308 ! opsonization GO:0008228 8 6 0,000 0,01940696 0,07762784 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01940696 0,07749307 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01940696 0,07735877 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01940696 0,07722493 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01940696 0,07709155 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01940696 0,07695864 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01940696 0,07682618 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01940696 0,07669418 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01940696 0,07656262 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01940696 0,07643152 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01940696 0,07630087 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01940696 0,07617067 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01940696 0,0760409 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01940696 0,07591158 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01940696 0,0757827 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01940696 0,07565425 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01940696 0,07552624 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01940696 0,07539867 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01940696 0,07527152 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01940696 0,0751448 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01940696 0,0750185 ! thymic T cell selection GO:0045061 12 6 0,000 0,01940696 0,07489263 ! protein lipoylation GO:0009249 10 6 0,000 0,01940696 0,07476719 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01940696 0,07464216 ! pigment granule organization GO:0048753 11 6 0,000 0,01940696 0,07451755 ! drug transport GO:0015893 6 6 0,000 0,01940696 0,07439335 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01940696 0,07426957 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01940696 0,0741462 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01940696 0,07402323 ! histidine metabolic process GO:0006547 6 6 0,000 0,01940696 0,07390068 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01940696 0,07377853 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01940696 0,07365678 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01940696 0,07353544 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01940696 0,07341449 ! adenohypophysis development GO:0021984 10 6 0,000 0,01940696 0,07329394 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01940696 0,07317379 ! hyperosmotic response GO:0006972 8 6 0,000 0,01940696 0,07305403 ! microtubule nucleation GO:0007020 10 6 0,000 0,01940696 0,07293466 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01940696 0,07281568 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01940696 0,07269708 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01940696 0,07257888 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01940696 0,07246106 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01940696 0,07234361 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01940696 0,07222655 ! response to dietary excess GO:0002021 7 6 0,000 0,01940696 0,07210987 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01940696 0,07199356 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01940696 0,07187763 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01940696 0,07176207 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01940696 0,07164689 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01940696 0,07153207 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01940696 0,07141762 ! neuron apoptosis GO:0051402 8 6 0,000 0,01940696 0,07130353 ! organic alcohol transport GO:0015850 9 6 0,000 0,01940696 0,07118981 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01940696 0,07107645 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01940696 0,07096345 ! carnitine transport GO:0015879 8 6 0,000 0,01940696 0,07085081 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01940696 0,07073853 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01940696 0,0706266 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01940696 0,07051502 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01940696 0,0704038 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01940696 0,07029293 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01940696 0,07018241 ! parturition GO:0007567 12 6 0,000 0,01940696 0,07007223 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01940696 0,0699624 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01940696 0,06985291 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01940696 0,06974377 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01940696 0,06963496 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01940696 0,0695265 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01940696 0,06941837 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01940696 0,06931057 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01940696 0,06920312 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01940696 0,06909599 ! astrocyte development GO:0014002 14 6 0,000 0,01940696 0,0689892 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01940696 0,06888273 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01940696 0,06877659 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01940696 0,06867078 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01940696 0,0685653 ! eating behavior GO:0042755 6 6 0,000 0,01940696 0,06846014 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01940696 0,0683553 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01940696 0,06825078 ! response to copper ion GO:0046688 9 6 0,000 0,01940696 0,06814658 ! DNA topological change GO:0006265 8 6 0,000 0,01940696 0,0680427 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01940696 0,06793913 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01940696 0,06783588 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01940696 0,06773294 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01940696 0,06763032 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01940696 0,067528 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01940696 0,067426 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01940696 0,0673243 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01940696 0,06722291 ! hair follicle maturation GO:0048820 7 6 0,000 0,01940696 0,06712182 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01940696 0,06702104 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01940696 0,06692055 ! Schwann cell development GO:0014044 14 6 0,000 0,01940696 0,06682037 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01940696 0,06672049 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01940696 0,06662091 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01940696 0,06652162 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01940696 0,06642263 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01940696 0,06632394 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01940696 0,06622553 ! histone ubiquitination GO:0016574 7 6 0,000 0,01940696 0,06612742 ! regulation of meiosis GO:0040020 10 6 0,000 0,01940696 0,0660296 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01940696 0,06593207 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01940696 0,06583482 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01940696 0,06573786 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01940696 0,06564119 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01940696 0,0655448 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01940696 0,0654487 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01940696 0,06535287 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01940696 0,06525732 ! receptor internalization GO:0031623 9 6 0,000 0,01940696 0,06516206 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01940696 0,06506707 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01940696 0,06497236 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01940696 0,06487792 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01940696 0,06478376 ! protein deubiquitination GO:0016579 8 6 0,000 0,01940696 0,06468987 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01940696 0,06459625 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01940696 0,0645029 ! axonal fasciculation GO:0007413 9 6 0,000 0,01940696 0,06440983 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01940696 0,06431702 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01940696 0,06422447 ! midbrain development GO:0030901 6 6 0,000 0,01940696 0,0641322 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01940696 0,06404019 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01940696 0,06394844 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01940696 0,06385695 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01940696 0,06376573 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01940696 0,06367476 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01940696 0,06358406 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01940696 0,06349361 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01940696 0,06340342 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01940696 0,06331349 ! adult feeding behavior GO:0008343 6 6 0,000 0,01940696 0,06322381 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01940696 0,06313438 ! blastocyst growth GO:0001832 15 6 0,000 0,01940696 0,06304521 ! pigment granule transport GO:0051904 12 6 0,000 0,01940696 0,06295629 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01940696 0,06286762 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01940696 0,0627792 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01940696 0,06269103 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01940696 0,0626031 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01940696 0,06251542 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01940696 0,06242799 ! protein prenylation GO:0018342 10 6 0,000 0,01940696 0,0623408 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01940696 0,06225385 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01940696 0,06216714 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01940696 0,06208068 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,01960554 0,06262882 ! acute inflammatory response GO:0002526 92 68 1,000 0,02073518 0,06614552 ! response to drug GO:0042493 108 69 1,000 0,02131002 0,06788509 ! humoral immune response GO:0006959 86 70 1,000 0,02189146 0,06964088 ! amine transport GO:0015837 101 70 1,000 0,02189146 0,06954469 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,02189146 0,06944877 ! regulation of catabolic process GO:0009894 106 70 1,000 0,02189146 0,06935311 ! muscle cell differentiation GO:0042692 104 71 1,000 0,02247947 0,07111799 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,02247947 0,0710203 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,02247947 0,07092287 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02260528 0,07122211 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02260528 0,07112468 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02260528 0,07102752 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02260528 0,07093062 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02260528 0,07083398 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02260528 0,07073761 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02260528 0,0706415 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02260528 0,07054565 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02260528 0,07045006 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02260528 0,07035472 ! reproductive behavior GO:0019098 12 7 0,000 0,02260528 0,07025965 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02260528 0,07016483 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02260528 0,07007027 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,02260528 0,06997596 ! oligopeptide transport GO:0006857 11 7 0,000 0,02260528 0,06988191 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02260528 0,06978811 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02260528 0,06969456 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! RNA methylation GO:0001510 11 7 0,000 0,02260528 0,06960126 ! pericardium development GO:0060039 8 7 0,000 0,02260528 0,06950821 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02260528 0,06941541 ! fibril organization GO:0043206 13 7 0,000 0,02260528 0,06932285 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02260528 0,06923055 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02260528 0,06913849 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,02260528 0,06904667 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02260528 0,06895509 ! lipoprotein transport GO:0042953 9 7 0,000 0,02260528 0,06886376 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02260528 0,06877267 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02260528 0,06868182 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02260528 0,06859122 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02260528 0,06850084 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02260528 0,06841071 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02260528 0,06832082 ! chemosensory behavior GO:0007635 9 7 0,000 0,02260528 0,06823116 ! microtubule bundle formation GO:0001578 8 7 0,000 0,02260528 0,06814173 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02260528 0,06805254 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02260528 0,06796358 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02260528 0,06787486 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02260528 0,06778636 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02260528 0,0676981 ! reflex GO:0060004 12 7 0,000 0,02260528 0,06761007 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02260528 0,06752226 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02260528 0,06743468 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02260528 0,06734733 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02260528 0,06726021 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02260528 0,06717331 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02260528 0,06708663 ! spinal cord patterning GO:0021511 7 7 0,000 0,02260528 0,06700018 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02260528 0,06691395 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02260528 0,06682794 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02260528 0,06674216 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02260528 0,06665659 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02260528 0,06657124 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02260528 0,06648611 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02260528 0,0664012 ! endosome organization GO:0007032 10 7 0,000 0,02260528 0,06631651 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02260528 0,06623203 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,02260528 0,06614776 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02260528 0,06606371 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02260528 0,06597987 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02260528 0,06589625 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02260528 0,06581284 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02260528 0,06572963 ! galactose metabolic process GO:0006012 10 7 0,000 0,02260528 0,06564664 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02260528 0,06556386 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02260528 0,06548129 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02260528 0,06539892 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02260528 0,06531676 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02260528 0,06523481 ! retinol metabolic process GO:0042572 9 7 0,000 0,02260528 0,06515306 ! behavioral fear response GO:0001662 13 7 0,000 0,02260528 0,06507152 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,02260528 0,06499018 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02260528 0,06490904 ! rRNA modification GO:0000154 12 7 0,000 0,02260528 0,06482811 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02260528 0,06474737 ! response to UV-B GO:0010224 11 7 0,000 0,02260528 0,06466684 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02260528 0,06458651 ! intermediate filament organization GO:0045109 11 7 0,000 0,02260528 0,06450638 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02260528 0,06442645 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02260528 0,06434671 ! fibrinolysis GO:0042730 9 7 0,000 0,02260528 0,06426717 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,02260528 0,06418783 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02260528 0,06410868 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02260528 0,06402973 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02260528 0,06395097 ! response to tropane GO:0014073 13 7 0,000 0,02260528 0,06387241 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02260528 0,06379404 ! melanosome localization GO:0032400 10 7 0,000 0,02260528 0,06371586 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02260528 0,06363787 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02260528 0,06356007 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02260528 0,06348247 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02260528 0,06340505 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02260528 0,06332782 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02260528 0,06325078 ! mast cell activation GO:0045576 9 7 0,000 0,02260528 0,06317393 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02260528 0,06309726 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02260528 0,06302078 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02260528 0,06294448 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02260528 0,06286837 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02260528 0,06279244 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02260528 0,0627167 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02260528 0,06264113 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02260528 0,06256575 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02260528 0,06249055 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02260528 0,06241554 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02260528 0,0623407 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02260528 0,06226604 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02260528 0,06219156 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02260528 0,06211725 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02260528 0,06204313 ! diuresis GO:0030146 12 7 0,000 0,02260528 0,06196918 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02260528 0,06189541 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02260528 0,06182181 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02260528 0,06174839 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02260528 0,06167514 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02260528 0,06160206 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02260528 0,06152916 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02260528 0,06145643 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02260528 0,06138387 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02260528 0,06131149 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02260528 0,06123927 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02260528 0,06116722 ! lymph node development GO:0048535 9 7 0,000 0,02260528 0,06109535 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02260528 0,06102364 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,02260528 0,0609521 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02260528 0,06088073 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02260528 0,06080952 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02260528 0,06073848 ! ATP catabolic process GO:0006200 10 7 0,000 0,02260528 0,06066761 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02260528 0,0605969 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02260528 0,06052636 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02260528 0,06045598 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02260528 0,06038576 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02260528 0,06031571 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02260528 0,06024582 ! muscle adaptation GO:0043500 12 7 0,000 0,02260528 0,06017609 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02260528 0,06010652 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02260528 0,06003711 ! retina homeostasis GO:0001895 9 7 0,000 0,02260528 0,05996787 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02260528 0,05989878 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02260528 0,05982985 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,02260528 0,05976108 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02260528 0,05969247 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02260528 0,05962402 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02260528 0,05955572 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02260528 0,05948758 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,02307399 0,06065163 GO:0045937|positive regulation of phosphate metabolic process, ! tube morphogenesis GO:0035239 118 73 1,000 0,02367498 0,06216034 ! mitochondrion organization GO:0007005 104 73 1,000 0,02367498 0,06208947 ! protein import into nucleus GO:0006606 118 74 1,000 0,0242824 0,06360993 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,0242824 0,06353756 ! blood coagulation GO:0007596 116 75 1,000 0,02489619 0,06506958 GO:0050817|coagulation, ! nuclear import GO:0051170 121 75 1,000 0,02489619 0,06499572 ! response to unfolded protein GO:0006986 99 76 1,000 0,02551631 0,06653912 ! regulation of protein transport GO:0051223 114 76 1,000 0,02551631 0,06646377 GO:0070201|regulation of establishment of protein localization, ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02579335 0,06710939 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02579335 0,06703356 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,02579335 0,0669579 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02579335 0,06688241 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02579335 0,06680709 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02579335 0,06673194 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02579335 0,06665697 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02579335 0,06658215 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02579335 0,06650751 ! phosphate transport GO:0006817 10 8 0,000 0,02579335 0,06643303 ! N-glycan processing GO:0006491 12 8 0,000 0,02579335 0,06635872 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02579335 0,06628458 ! UTP metabolic process GO:0046051 8 8 0,000 0,02579335 0,0662106 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02579335 0,06613679 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02579335 0,06606314 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,02579335 0,06598965 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02579335 0,06591633 ! succinate metabolic process GO:0006105 14 8 0,000 0,02579335 0,06584317 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02579335 0,06577018 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02579335 0,06569734 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02579335 0,06562467 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,02579335 0,06555215 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02579335 0,0654798 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02579335 0,06540761 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02579335 0,06533557 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02579335 0,0652637 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02579335 0,06519198 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,02579335 0,06512042 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02579335 0,06504901 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02579335 0,06497776 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02579335 0,06490667 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02579335 0,06483574 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02579335 0,06476496 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,02579335 0,06469433 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02579335 0,06462386 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02579335 0,06455354 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02579335 0,06448337 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02579335 0,06441335 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02579335 0,06434349 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02579335 0,06427378 ! melanin metabolic process GO:0006582 12 8 0,000 0,02579335 0,06420422 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02579335 0,06413481 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02579335 0,06406555 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,02579335 0,06399644 ! macrophage activation GO:0042116 12 8 0,000 0,02579335 0,06392748 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02579335 0,06385866 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02579335 0,06379 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,02579335 0,06372148 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02579335 0,06365311 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02579335 0,06358489 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02579335 0,06351681 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02579335 0,06344888 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02579335 0,06338109 ! ruffle organization GO:0031529 11 8 0,000 0,02579335 0,06331345 ! osteoblast development GO:0002076 13 8 0,000 0,02579335 0,06324595 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02579335 0,06317859 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02579335 0,06311138 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02579335 0,06304431 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02579335 0,06297739 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02579335 0,0629106 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02579335 0,06284396 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02579335 0,06277746 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02579335 0,0627111 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02579335 0,06264488 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02579335 0,0625788 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02579335 0,06251285 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02579335 0,06244705 ! segment specification GO:0007379 10 8 0,000 0,02579335 0,06238139 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02579335 0,06231586 ! cellular extravasation GO:0045123 11 8 0,000 0,02579335 0,06225047 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02579335 0,06218522 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02579335 0,0621201 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02579335 0,06205512 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 0,000 0,02579335 0,06199028 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02579335 0,06192557 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02579335 0,061861 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,02579335 0,06179656 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02579335 0,06173226 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02579335 0,06166809 ! nucleosome disassembly GO:0006337 12 8 0,000 0,02579335 0,06160405 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02579335 0,06154014 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02579335 0,06147637 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02579335 0,06141273 ! icosanoid secretion GO:0032309 12 8 0,000 0,02579335 0,06134922 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,02579335 0,06128585 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02579335 0,0612226 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02579335 0,06115948 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02579335 0,0610965 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02579335 0,06103364 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02579335 0,06097091 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02579335 0,06090832 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02579335 0,06084585 ! sterol catabolic process GO:0016127 9 8 0,000 0,02579335 0,0607835 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02579335 0,06072129 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02579335 0,0606592 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02579335 0,06059724 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02579335 0,06053541 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02579335 0,0604737 ! prophase GO:0051324 11 8 0,000 0,02579335 0,06041212 ! S phase GO:0051320 8 8 0,000 0,02579335 0,06035066 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02579335 0,06028933 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02579335 0,06022812 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02579335 0,06016704 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02579335 0,06010608 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02579335 0,06004524 ! hormone catabolic process GO:0042447 13 8 0,000 0,02579335 0,05998453 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02579335 0,05992394 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02579335 0,05986347 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02579335 0,05980312 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02579335 0,0597429 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02579335 0,0596828 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02579335 0,05962281 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02579335 0,05956295 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02579335 0,05950321 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02579335 0,05944359 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02579335 0,05938408 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02579335 0,0593247 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02579335 0,05926543 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02579335 0,05920629 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02579335 0,05914726 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,02579335 0,05908835 ! regulation of DNA binding GO:0051101 119 77 1,000 0,02614271 0,05982908 ! T cell activation GO:0042110 134 79 1,000 0,02741418 0,06267654 ! protein localization in nucleus GO:0034504 133 80 1,000 0,02805915 0,06408743 ! hemostasis GO:0007599 125 81 1,000 0,02871022 0,06550944 ! mRNA transport GO:0051028 121 81 1,000 0,02871022 0,06544451 ! response to protein stimulus GO:0051789 111 81 1,000 0,02871022 0,06537972 ! regulation of neurological system process GO:0031644 122 81 1,000 0,02871022 0,06531505 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,02871022 0,06525051 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,0289712 0,06577864 ! telencephalon cell migration GO:0022029 16 9 0,000 0,0289712 0,06571377 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,0289712 0,06564902 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,0289712 0,06558441 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,0289712 0,06551992 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,0289712 0,06545556 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,0289712 0,06539132 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,0289712 0,06532721 ! GTP metabolic process GO:0046039 9 9 0,000 0,0289712 0,06526323 ! elastic fiber assembly GO:0048251 13 9 0,000 0,0289712 0,06519937 ! social behavior GO:0035176 14 9 0,000 0,0289712 0,06513564 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,0289712 0,06507203 ! artery development GO:0060840 19 9 0,000 0,0289712 0,06500854 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,0289712 0,06494518 ! response to pain GO:0048265 16 9 0,000 0,0289712 0,06488195 ! protein complex disassembly GO:0043241 17 9 0,000 0,0289712 0,06481883 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,0289712 0,06475584 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,0289712 0,06469297 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,0289712 0,06463022 ! lung alveolus development GO:0048286 17 9 0,000 0,0289712 0,06456759 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,0289712 0,06450509 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,0289712 0,06444271 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,0289712 0,06438044 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,0289712 0,0643183 ! ventral spinal cord development GO:0021517 11 9 0,000 0,0289712 0,06425628 ! protein targeting to ER GO:0045047 19 9 0,000 0,0289712 0,06419437 ! T cell selection GO:0045058 18 9 0,000 0,0289712 0,06413259 ! endoderm development GO:0007492 12 9 0,000 0,0289712 0,06407092 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,0289712 0,06400937 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,0289712 0,06394794 ! arginine catabolic process GO:0006527 10 9 0,000 0,0289712 0,06388663 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,0289712 0,06382544 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,0289712 0,06376436 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,0289712 0,0637034 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,0289712 0,06364256 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,0289712 0,06358183 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,0289712 0,06352122 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,0289712 0,06346072 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,0289712 0,06340034 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,0289712 0,06334007 ! mannose metabolic process GO:0006013 9 9 0,000 0,0289712 0,06327992 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,0289712 0,06321988 ! receptor clustering GO:0043113 15 9 0,000 0,0289712 0,06315996 ! epithelial cell development GO:0002064 10 9 0,000 0,0289712 0,06310015 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,0289712 0,06304045 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,0289712 0,06298087 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,0289712 0,0629214 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,0289712 0,06286204 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,0289712 0,06280279 ! motor axon guidance GO:0008045 14 9 0,000 0,0289712 0,06274365 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,0289712 0,06268463 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,0289712 0,06262571 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,0289712 0,06256691 ! blastoderm segmentation GO:0007350 11 9 0,000 0,0289712 0,06250822 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,0289712 0,06244963 ! DNA ligation GO:0006266 14 9 0,000 0,0289712 0,06239116 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,0289712 0,06233279 ! response to amine stimulus GO:0014075 13 9 0,000 0,0289712 0,06227454 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,0289712 0,06221639 ! erythrocyte development GO:0048821 11 9 0,000 0,0289712 0,06215836 ! renal water homeostasis GO:0003091 14 9 0,000 0,0289712 0,06210043 ! postreplication repair GO:0006301 11 9 0,000 0,0289712 0,0620426 ! mRNA cleavage GO:0006379 13 9 0,000 0,0289712 0,06198489 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,0289712 0,06192728 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,0289712 0,06186978 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,0289712 0,06181239 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,0289712 0,0617551 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,0289712 0,06169792 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,0289712 0,06164085 ! acid secretion GO:0046717 14 9 0,000 0,0289712 0,06158388 ! musculoskeletal movement GO:0050881 11 9 0,000 0,0289712 0,06152702 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,0289712 0,06147026 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,0289712 0,0614136 ! purine base metabolic process GO:0006144 18 9 0,000 0,0289712 0,06135705 ! oocyte differentiation GO:0009994 12 9 0,000 0,0289712 0,06130061 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,0289712 0,06124426 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,0289712 0,06118802 ! spleen development GO:0048536 15 9 0,000 0,0289712 0,06113189 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,0289712 0,06107585 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,0289712 0,06101992 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,0289712 0,0609641 ! detection of calcium ion GO:0005513 13 9 0,000 0,0289712 0,06090837 ! blastocyst formation GO:0001825 12 9 0,000 0,0289712 0,06085275 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,0289712 0,06079722 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,0289712 0,0607418 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,0289712 0,06068648 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,0289712 0,06063126 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,0289712 0,06057614 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,0289712 0,06052112 ! prepulse inhibition GO:0060134 14 9 0,000 0,0289712 0,0604662 ! embryonic placenta development GO:0001892 12 9 0,000 0,0289712 0,06041139 ! insulin secretion GO:0030073 17 9 0,000 0,0289712 0,06035666 ! sequestering of metal ion GO:0051238 11 9 0,000 0,0289712 0,06030204 ! response to nicotine GO:0035094 16 9 0,000 0,0289712 0,06024752 ! establishment of cell polarity GO:0030010 12 9 0,000 0,0289712 0,0601931 ! regulation of synapse organization GO:0050807 12 9 0,000 0,0289712 0,06013877 ! ossification GO:0001503 134 82 1,000 0,02936735 0,06090614 GO:0060348|bone development, ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,03003049 0,06222534 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,03003049 0,06216933 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,03137462 0,06489355 ! regulation of protein localization GO:0032880 132 85 1,000 0,03137462 0,06483524 ! regulation of membrane potential GO:0042391 128 85 1,000 0,03137462 0,06477704 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,03137462 0,06471895 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,03213887 0,06623601 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,03213887 0,06617672 ! neuron fate specification GO:0048665 11 10 0,000 0,03213887 0,06611752 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,03213887 0,06605844 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,03213887 0,06599946 ! thyroid gland development GO:0030878 19 10 0,000 0,03213887 0,06594058 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,03213887 0,06588181 ! synapsis GO:0007129 13 10 0,000 0,03213887 0,06582314 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,03213887 0,06576458 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,03213887 0,06570613 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,03213887 0,06564777 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,03213887 0,06558952 ! sulfate transport GO:0008272 12 10 0,000 0,03213887 0,06553138 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,03213887 0,06547333 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,03213887 0,06541539 ! phospholipid efflux GO:0033700 16 10 0,000 0,03213887 0,06535755 ! hippocampus development GO:0021766 19 10 0,000 0,03213887 0,06529982 ! blood vessel remodeling GO:0001974 21 10 0,000 0,03213887 0,06524218 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,03213887 0,06518465 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,03213887 0,06512722 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,03213887 0,06506989 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,03213887 0,06501266 ! pathogenesis GO:0009405 13 10 0,000 0,03213887 0,06495553 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,03213887 0,0648985 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03213887 0,06484157 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,03213887 0,06478474 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,03213887 0,06472801 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,03213887 0,06467138 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,03213887 0,06461485 ! melanocyte differentiation GO:0030318 15 10 0,000 0,03213887 0,06455842 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,03213887 0,06450209 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,03213887 0,06444585 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,03213887 0,06438971 ! B cell proliferation GO:0042100 14 10 0,000 0,03213887 0,06433367 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,03213887 0,06427773 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,03213887 0,06422189 ! forebrain cell migration GO:0021885 17 10 0,000 0,03213887 0,06416614 ! lipid digestion GO:0044241 15 10 0,000 0,03213887 0,06411049 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,03213887 0,06405493 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,03213887 0,06399947 ! UV protection GO:0009650 14 10 0,000 0,03213887 0,06394411 ! entry into host cell GO:0030260 20 10 0,000 0,03213887 0,06388884 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,03213887 0,06383367 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,03213887 0,06377859 ! negative regulation of ossification GO:0030279 19 10 0,000 0,03213887 0,06372361 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,03213887 0,06366873 ! regulation of bone resorption GO:0045124 24 10 0,000 0,03213887 0,06361393 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,03213887 0,06355924 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,03213887 0,06350463 ! regulation of organ growth GO:0046620 11 10 0,000 0,03213887 0,06345012 ! response to dsRNA GO:0043331 18 10 0,000 0,03213887 0,0633957 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,03213887 0,06334138 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,03213887 0,06328715 ! embryonic axis specification GO:0000578 12 10 0,000 0,03213887 0,06323301 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,03213887 0,06317897 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,03213887 0,06312501 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,03213887 0,06307115 ! cranial nerve development GO:0021545 12 10 0,000 0,03213887 0,06301738 ! fucose catabolic process GO:0019317 16 10 0,000 0,03213887 0,06296371 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,03213887 0,06291012 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,03213887 0,06285663 ! protein sumoylation GO:0016925 12 10 0,000 0,03213887 0,06280322 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,03213887 0,06274991 ! zymogen activation GO:0031638 14 10 0,000 0,03213887 0,06269668 ! salivary gland development GO:0007431 22 10 0,000 0,03213887 0,06264355 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,03213887 0,06259051 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,03213887 0,06253756 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,03213887 0,06248469 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,03213887 0,06243192 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,03213887 0,06237923 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,03213887 0,06232664 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,03213887 0,06227413 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,03213887 0,06222171 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,03213887 0,06216938 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,03213887 0,06211714 ! detection of bacterium GO:0016045 10 10 0,000 0,03213887 0,06206498 ! embryonic gut development GO:0048566 11 10 0,000 0,03213887 0,06201291 ! activation of innate immune response GO:0002218 10 10 0,000 0,03213887 0,06196093 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,03213887 0,06190904 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,03213887 0,06185723 ! developmental induction GO:0031128 13 10 0,000 0,03213887 0,06180551 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,03213887 0,06175388 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,03213887 0,06170233 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,03213887 0,06165087 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,03213887 0,06159949 ! establishment of RNA localization GO:0051236 128 88 1,000 0,03343478 0,06402997 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 1,000 0,03343478 0,0639767 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,03413305 0,06525853 ! reproductive developmental process GO:0003006 127 89 1,000 0,03413305 0,06520432 ! rRNA transcription GO:0009303 17 11 0,000 0,03529638 0,06737068 ! respiratory burst GO:0045730 14 11 0,000 0,03529638 0,06731482 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,03529638 0,06725905 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,03529638 0,06720337 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,03529638 0,06714779 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,03529638 0,06709229 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,03529638 0,06703689 ! RNA polyadenylation GO:0043631 19 11 0,000 0,03529638 0,06698158 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,03529638 0,06692636 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,03529638 0,06687123 ! mating GO:0007618 14 11 0,000 0,03529638 0,06681619 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,03529638 0,06676124 ! T cell proliferation GO:0042098 20 11 0,000 0,03529638 0,06670639 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,03529638 0,06665162 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,03529638 0,06659694 ! bone resorption GO:0045453 16 11 0,000 0,03529638 0,06654236 ! regulated secretory pathway GO:0045055 14 11 0,000 0,03529638 0,06648786 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,03529638 0,06643345 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,03529638 0,06637913 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,03529638 0,0663249 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,03529638 0,06627075 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,03529638 0,0662167 ! syncytium formation GO:0006949 15 11 0,000 0,03529638 0,06616273 ! plasma membrane organization GO:0007009 18 11 0,000 0,03529638 0,06610885 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,03529638 0,06605506 ! focal adhesion formation GO:0048041 24 11 0,000 0,03529638 0,06600136 ! mitotic spindle organization GO:0007052 15 11 0,000 0,03529638 0,06594774 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,03529638 0,06589422 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,03529638 0,06584077 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,03529638 0,06578742 ! adult heart development GO:0007512 11 11 0,000 0,03529638 0,06573415 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,03529638 0,06568097 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,03529638 0,06562787 ! temperature homeostasis GO:0001659 16 11 0,000 0,03529638 0,06557486 ! L-glutamate transport GO:0015813 16 11 0,000 0,03529638 0,06552193 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,03529638 0,06546909 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,03529638 0,06541634 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,03529638 0,06536367 ! stem cell development GO:0048864 29 11 0,000 0,03529638 0,06531108 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,03529638 0,06525858 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,03529638 0,06520616 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,03529638 0,06515383 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,03529638 0,06510158 ! vasoconstriction GO:0042310 15 11 0,000 0,03529638 0,06504942 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,03529638 0,06499734 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,03529638 0,06494534 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,03529638 0,06489342 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,03529638 0,06484159 ! ribosome assembly GO:0042255 13 11 0,000 0,03529638 0,06478984 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,03529638 0,06473818 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,03529638 0,06468659 ! chromatin silencing GO:0006342 19 11 0,000 0,03529638 0,06463509 ! nucleosome positioning GO:0016584 13 11 0,000 0,03529638 0,06458367 ! T cell homeostasis GO:0043029 20 11 0,000 0,03529638 0,06453233 ! regulation of isotype switching GO:0045191 19 11 0,000 0,03529638 0,06448108 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,03529638 0,0644299 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,03529638 0,06437881 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,03529638 0,06432779 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,03529638 0,06427686 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,03529638 0,06422601 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,03529638 0,06417524 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,03529638 0,06412454 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,03529638 0,06407393 ! male genitalia development GO:0030539 13 11 0,000 0,03529638 0,0640234 ! cholesterol efflux GO:0033344 19 11 0,000 0,03529638 0,06397295 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,03529638 0,06392258 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,03529638 0,06387228 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,03529638 0,06382207 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,03529638 0,06377194 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,03529638 0,06372188 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,03529638 0,0636719 ! negative regulation of mast cell proliferation GO:0070667 17 11 0,000 0,03529638 0,063622 GO:0042130|negative regulation of T cell proliferation, ! defense response to fungus GO:0050832 12 11 0,000 0,03529638 0,06357218 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,03529638 0,06352244 ! lysogeny GO:0030069 18 11 0,000 0,03529638 0,06347277 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,03529638 0,06342318 ! acrosome reaction GO:0007340 13 11 0,000 0,03529638 0,06337367 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,03529638 0,06332424 ! RNA localization GO:0006403 135 91 1,000 0,03554664 0,06372352 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,03626189 0,06495509 ! positive regulation of immune response GO:0050778 121 92 1,000 0,03626189 0,06490455 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,0369827 0,06614325 ! regulation of binding GO:0051098 151 95 1,000 0,03844089 0,06869778 ! lactation GO:0007595 20 12 0,000 0,03844377 0,06864959 ! reproductive cellular process GO:0048610 14 12 0,000 0,03844377 0,06859634 ! tRNA modification GO:0006400 14 12 0,000 0,03844377 0,06854316 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,03844377 0,06849007 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,03844377 0,06843706 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,03844377 0,06838413 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,03844377 0,06833128 ! non-recombinational repair GO:0000726 19 12 0,000 0,03844377 0,06827852 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,03844377 0,06822583 ! peroxisomal transport GO:0043574 21 12 0,000 0,03844377 0,06817323 ! cartilage condensation GO:0001502 18 12 0,000 0,03844377 0,06812071 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,03844377 0,06806827 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,03844377 0,06801591 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,03844377 0,06796363 ! heart looping GO:0001947 15 12 0,000 0,03844377 0,06791143 ! palate development GO:0060021 15 12 0,000 0,03844377 0,06785931 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,03844377 0,06780727 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,03844377 0,06775531 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,03844377 0,06770343 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,03844377 0,06765163 ! arginine metabolic process GO:0006525 13 12 0,000 0,03844377 0,06759991 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,03844377 0,06754826 ! methionine metabolic process GO:0006555 13 12 0,000 0,03844377 0,0674967 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,03844377 0,06744522 ! Golgi organization GO:0007030 18 12 0,000 0,03844377 0,06739381 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,03844377 0,06734248 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,03844377 0,06729123 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03844377 0,06724006 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,03844377 0,06718896 ! L-amino acid transport GO:0015807 20 12 0,000 0,03844377 0,06713795 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,03844377 0,06708701 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,03844377 0,06703615 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,03844377 0,06698536 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,03844377 0,06693465 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,03844377 0,06688402 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,03844377 0,06683347 ! cerebellum development GO:0021549 13 12 0,000 0,03844377 0,06678299 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,03844377 0,06673259 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,03844377 0,06668226 ! histone methylation GO:0016571 15 12 0,000 0,03844377 0,06663201 ! autonomic nervous system development GO:0048483 23 12 0,000 0,03844377 0,06658184 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,03844377 0,06653174 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,03844377 0,06648171 ! regulation of epidermis development GO:0045682 17 12 0,000 0,03844377 0,06643176 ! intestinal absorption GO:0050892 19 12 0,000 0,03844377 0,06638189 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,03844377 0,06633209 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,03844377 0,06628237 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,03844377 0,06623272 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,03844377 0,06618314 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,03844377 0,06613364 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,03844377 0,06608421 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,03844377 0,06603486 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,03844377 0,06598558 ! response to cold GO:0009409 14 12 0,000 0,03844377 0,06593637 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,03917817 0,06714589 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,03917817 0,06709589 ! protein maturation GO:0051604 129 96 1,000 0,03917817 0,06704597 ! calcium ion transport GO:0006816 167 99 1,000 0,04142226 0,07083361 ! protein import GO:0017038 156 99 1,000 0,04142226 0,07078099 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,04158108 0,07099961 ! cGMP metabolic process GO:0046068 16 13 0,000 0,04158108 0,07094694 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,04158108 0,07089435 ! water transport GO:0006833 17 13 0,000 0,04158108 0,07084184 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,04158108 0,0707894 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,04158108 0,07073704 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,04158108 0,07068476 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,04158108 0,07063255 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,04158108 0,07058043 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,04158108 0,07052838 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,04158108 0,0704764 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,04158108 0,0704245 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,04158108 0,07037268 ! response to hexose stimulus GO:0009746 19 13 0,000 0,04158108 0,07032094 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,04158108 0,07026927 ! glutamate metabolic process GO:0006536 18 13 0,000 0,04158108 0,07021768 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,04158108 0,07016616 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,04158108 0,07011472 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,04158108 0,07006335 ! NAD metabolic process GO:0019674 21 13 0,000 0,04158108 0,07001206 ! exocrine system development GO:0035272 27 13 0,000 0,04158108 0,06996085 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,04158108 0,06990971 ! bone mineralization GO:0030282 15 13 0,000 0,04158108 0,06985864 ! regulation of exocytosis GO:0017157 17 13 0,000 0,04158108 0,06980765 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,04158108 0,06975673 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,04158108 0,06970589 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,04158108 0,06965512 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,04158108 0,06960442 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,04158108 0,0695538 ! genitalia development GO:0048806 15 13 0,000 0,04158108 0,06950325 ! cellular pigmentation GO:0033059 24 13 0,000 0,04158108 0,06945278 ! tissue regeneration GO:0042246 21 13 0,000 0,04158108 0,06940238 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,04158108 0,06935205 ! cofactor transport GO:0051181 19 13 0,000 0,04158108 0,0693018 ! NADP metabolic process GO:0006739 18 13 0,000 0,04158108 0,06925161 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,04158108 0,0692015 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,04158108 0,06915147 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,04158108 0,0691015 ! gas transport GO:0015669 18 13 0,000 0,04158108 0,06905161 ! regulation of RNA stability GO:0043487 28 13 0,000 0,04158108 0,06900179 ! heme biosynthetic process GO:0006783 20 13 0,000 0,04158108 0,06895204 ! regulation of axon extension GO:0030516 23 13 0,000 0,04158108 0,06890236 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,04158108 0,06885276 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,04158108 0,06880322 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,04158108 0,06875376 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,04158108 0,06870437 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,04158108 0,06865504 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,04158108 0,06860579 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,04218091 0,06954559 ! divalent metal ion transport GO:0070838 171 100 1,000 0,04218091 0,06949577 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,04218091 0,06944602 ! protein localization in organelle GO:0033365 161 100 1,000 0,04218091 0,06939635 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,04470832 0,07350189 ! superoxide anion generation GO:0042554 18 14 0,000 0,04470832 0,07344939 ! neuron maturation GO:0042551 21 14 0,000 0,04470832 0,07339696 ! regulation of S phase GO:0033261 18 14 0,000 0,04470832 0,07334461 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,04470832 0,07329233 ! myotube differentiation GO:0014902 21 14 0,000 0,04470832 0,07324013 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,04470832 0,073188 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,04470832 0,07313595 ! inositol metabolic process GO:0006020 20 14 0,000 0,04470832 0,07308397 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,04470832 0,07303206 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,04470832 0,07298023 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,04470832 0,07292847 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,04470832 0,07287679 ! gene silencing by RNA GO:0031047 20 14 0,000 0,04470832 0,07282517 ! response to cAMP GO:0051591 19 14 0,000 0,04470832 0,07277363 ! limbic system development GO:0021761 25 14 0,000 0,04470832 0,07272217 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,04470832 0,07267077 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,04470832 0,07261945 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,04470832 0,0725682 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,04470832 0,07251703 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,04470832 0,07246592 ! glycine metabolic process GO:0006544 22 14 0,000 0,04470832 0,07241489 ! pituitary gland development GO:0021983 23 14 0,000 0,04470832 0,07236393 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,04470832 0,07231304 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,04470832 0,07226222 ! regulation of heart rate GO:0002027 23 14 0,000 0,04470832 0,07221148 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,04470832 0,0721608 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,04470832 0,0721102 ! embryo implantation GO:0007566 27 14 0,000 0,04470832 0,07205967 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,04470832 0,07200921 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,04470832 0,07195881 ! axon cargo transport GO:0008088 27 14 0,000 0,04470832 0,07190849 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,04470832 0,07185824 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,04470832 0,07180806 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,04470832 0,07175795 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,04470832 0,07170791 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,04470832 0,07165794 ! mRNA splice site selection GO:0006376 26 14 0,000 0,04470832 0,07160804 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,04470832 0,07155821 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,04470832 0,07150845 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,04470832 0,07145875 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,04470832 0,07140913 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,04470832 0,07135957 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,04470832 0,07131009 ! muscle maintenance GO:0046716 19 14 0,000 0,04470832 0,07126067 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,04470832 0,07121132 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,04470832 0,07116204 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,04470832 0,07111283 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,04470832 0,07106368 ! cilium assembly GO:0042384 20 14 0,000 0,04470832 0,0710146 ! peptide hormone secretion GO:0030072 23 14 0,000 0,04470832 0,07096559 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,04782555 0,07586121 ! positive regulation of cell size GO:0045793 20 15 0,000 0,04782555 0,07580893 ! metencephalon development GO:0022037 19 15 0,000 0,04782555 0,07575672 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,04782555 0,07570458 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,04782555 0,07565251 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,04782555 0,07560052 ! skin development GO:0043588 25 15 0,000 0,04782555 0,0755486 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,04782555 0,07549674 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,04782555 0,07544496 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,04782555 0,07539325 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,04782555 0,07534161 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,04782555 0,07529004 ! bile acid metabolic process GO:0008206 22 15 0,000 0,04782555 0,07523855 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,04782555 0,07518712 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,04782555 0,07513576 ! adult walking behavior GO:0007628 25 15 0,000 0,04782555 0,07508447 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,04782555 0,07503326 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,04782555 0,07498211 ! centrosome cycle GO:0007098 16 15 0,000 0,04782555 0,07493103 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,04782555 0,07488002 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,04782555 0,07482909 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,04782555 0,07477822 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,04782555 0,07472742 ! cerebral cortex development GO:0021987 29 15 0,000 0,04782555 0,07467668 ! response to osmotic stress GO:0006970 22 15 0,000 0,04782555 0,07462602 ! vesicle coating GO:0006901 25 15 0,000 0,04782555 0,07457543 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,04782555 0,0745249 ! DNA integration GO:0015074 22 15 0,000 0,04782555 0,07447445 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,04782555 0,07442406 ! peptide secretion GO:0002790 27 15 0,000 0,04782555 0,07437374 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,04782555 0,07432348 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,04782555 0,0742733 ! neuron recognition GO:0008038 22 15 0,000 0,04782555 0,07422318 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,04782555 0,07417313 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,04782555 0,07412315 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,04782555 0,07407324 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,04782555 0,07402339 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,04782555 0,07397361 ! biomineral formation GO:0031214 18 15 0,000 0,04782555 0,07392389 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,04782555 0,07387425 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,04782555 0,07382467 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,04782555 0,07377515 ! dopamine metabolic process GO:0042417 30 15 0,000 0,04782555 0,07372571 ! organic cation transport GO:0015695 19 15 0,000 0,04782555 0,07367633 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,04782555 0,07362701 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,04782555 0,07357776 ! negative regulation of leukocyte proliferation GO:0070664 25 15 0,000 0,04782555 0,07352858 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 0,000 0,04782555 0,07347946 ! peptide hormone processing GO:0016486 19 15 0,000 0,04782555 0,07343041 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,04782555 0,07338142 ! protein secretion GO:0009306 27 16 0,000 0,05093277 0,07809692 ! hormone secretion GO:0046879 25 16 0,000 0,05093277 0,07804489 ! bone remodeling GO:0046849 24 16 0,000 0,05093277 0,07799293 ! endothelial cell migration GO:0043542 22 16 0,000 0,05093277 0,07794104 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,05093277 0,07788921 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05093277 0,07783746 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,05093277 0,07778578 ! glial cell development GO:0021782 24 16 0,000 0,05093277 0,07773416 ! patterning of blood vessels GO:0001569 24 16 0,000 0,05093277 0,07768261 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,05093277 0,07763113 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,05093277 0,07757972 ! protein polyubiquitination GO:0000209 26 16 0,000 0,05093277 0,07752838 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,05093277 0,0774771 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,05093277 0,07742589 ! fructose metabolic process GO:0006000 20 16 0,000 0,05093277 0,07737475 ! regulation of protein binding GO:0043393 27 16 0,000 0,05093277 0,07732368 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,05093277 0,07727268 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,05093277 0,07722174 ! protein export from nucleus GO:0006611 24 16 0,000 0,05093277 0,07717087 ! negative regulation of immune response GO:0050777 28 16 0,000 0,05093277 0,07712006 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,05093277 0,07706933 ! DNA replication initiation GO:0006270 25 16 0,000 0,05093277 0,07701866 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,05093277 0,07696805 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,05093277 0,07691752 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,05093277 0,07686705 ! diencephalon development GO:0021536 25 16 0,000 0,05093277 0,07681664 ! oogenesis GO:0048477 23 16 0,000 0,05093277 0,0767663 ! neural crest cell migration GO:0001755 24 16 0,000 0,05093277 0,07671603 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,05093277 0,07666582 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,05093277 0,07661568 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,05093277 0,07656561 ! steroid catabolic process GO:0006706 22 16 0,000 0,05093277 0,0765156 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,05093277 0,07646565 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,05093277 0,07641577 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,05093277 0,07636596 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,05093277 0,07631621 ! sperm-egg recognition GO:0035036 16 16 0,000 0,05093277 0,07626652 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,05093277 0,0762169 ! nerve development GO:0021675 18 16 0,000 0,05093277 0,07616735 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,05093277 0,07611785 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,05093277 0,07606843 ! negative regulation of translation GO:0017148 22 16 0,000 0,05093277 0,07601906 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,05403004 0,08058955 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,05403004 0,08053732 ! negative regulation of defense response GO:0031348 19 17 0,000 0,05403004 0,08048516 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,05403004 0,08043307 ! glycerol metabolic process GO:0006071 20 17 0,000 0,05403004 0,08038104 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,05403004 0,08032908 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,05403004 0,08027719 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,05403004 0,08022536 ! signal complex assembly GO:0007172 29 17 0,000 0,05403004 0,08017361 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,05403004 0,08012191 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,05403004 0,08007029 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,05403004 0,08001873 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,05403004 0,07996724 ! memory GO:0007613 25 17 0,000 0,05403004 0,07991581 ! keratinization GO:0031424 17 17 0,000 0,05403004 0,07986445 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,05403004 0,07981316 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,05403004 0,07976193 ! retinoid metabolic process GO:0001523 22 17 0,000 0,05403004 0,07971077 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,05403004 0,07965967 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,05403004 0,07960864 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,05403004 0,07955768 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,05403004 0,07950677 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,05403004 0,07945594 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,05403004 0,07940517 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,05403004 0,07935446 ! membrane budding GO:0006900 29 17 0,000 0,05403004 0,07930382 ! heme metabolic process GO:0042168 27 17 0,000 0,05403004 0,07925325 ! actin filament bundle formation GO:0051017 26 17 0,000 0,05403004 0,07920273 ! neuromuscular junction development GO:0007528 23 17 0,000 0,05403004 0,07915229 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,05403004 0,0791019 ! body fluid secretion GO:0007589 27 17 0,000 0,05403004 0,07905158 ! stem cell differentiation GO:0048863 36 17 0,000 0,05403004 0,07900133 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,05403004 0,07895114 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,05403004 0,07890101 ! sensory perception of pain GO:0019233 23 17 0,000 0,05403004 0,07885094 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,05403004 0,07880094 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,05403004 0,07875101 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,05403004 0,07870113 ! synaptogenesis GO:0007416 24 17 0,000 0,05403004 0,07865132 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,05403004 0,07860157 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,05403004 0,07855189 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,05403004 0,07850227 ! cell-cell junction organization GO:0045216 25 17 0,000 0,05403004 0,07845271 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,05403004 0,07840321 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,05403004 0,07835378 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,05403004 0,0783044 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,05403004 0,07825509 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,05403004 0,07820585 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,05403004 0,07815666 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,05711737 0,08257068 ! positive regulation of translation GO:0045727 28 18 0,000 0,05711737 0,08251882 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,05711737 0,08246702 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,05711737 0,08241528 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,05711737 0,08236361 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,05711737 0,082312 ! cAMP metabolic process GO:0046058 33 18 0,000 0,05711737 0,08226046 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,05711737 0,08220898 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,05711737 0,08215757 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,05711737 0,08210622 ! axis specification GO:0009798 26 18 0,000 0,05711737 0,08205494 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,05711737 0,08200372 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,05711737 0,08195256 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,05711737 0,08190147 ! glutamine metabolic process GO:0006541 23 18 0,000 0,05711737 0,08185044 ! response to retinoic acid GO:0032526 25 18 0,000 0,05711737 0,08179947 ! pigmentation during development GO:0048066 31 18 0,000 0,05711737 0,08174857 ! central nervous system neuron development GO:0021954 30 18 0,000 0,05711737 0,08169773 ! fucose metabolic process GO:0006004 26 18 0,000 0,05711737 0,08164696 ! response to fungus GO:0009620 19 18 0,000 0,05711737 0,08159625 ! peptide cross-linking GO:0018149 31 18 0,000 0,05711737 0,0815456 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,05711737 0,08149501 ! heart process GO:0003015 27 18 0,000 0,05711737 0,08144449 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,05711737 0,08139403 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,05711737 0,08134363 ! visual learning GO:0008542 35 18 0,000 0,05711737 0,08129329 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,05711737 0,08124302 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,05711737 0,0811928 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,05711737 0,08114265 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,05711737 0,08109257 ! vitamin transport GO:0051180 24 18 0,000 0,05711737 0,08104254 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,05711737 0,08099257 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,05711737 0,08094267 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,05711737 0,08089283 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,05711737 0,08084305 ! cell-cell recognition GO:0009988 20 18 0,000 0,05711737 0,08079333 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,05711737 0,08074367 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,05711737 0,08069408 ! regulation of glucose import GO:0046324 21 18 0,000 0,05711737 0,08064454 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,05711737 0,08059507 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,05711737 0,08054565 ! negative regulation of T cell activation GO:0050868 25 18 0,000 0,05711737 0,0804963 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,06019481 0,08478142 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,06019481 0,08472953 ! positive regulation of ossification GO:0045778 30 19 0,000 0,06019481 0,08467771 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,06019481 0,08462595 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,06019481 0,08457425 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,06019481 0,08452262 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,06019481 0,08447105 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,06019481 0,08441955 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,06019481 0,0843681 ! regeneration GO:0031099 32 19 0,000 0,06019481 0,08431672 ! response to alkaloid GO:0043279 32 19 0,000 0,06019481 0,0842654 ! sensory perception of taste GO:0050909 23 19 0,000 0,06019481 0,08421415 ! smooth muscle contraction GO:0006939 36 19 0,000 0,06019481 0,08416295 ! peroxisome organization GO:0007031 29 19 0,000 0,06019481 0,08411182 ! digestive system process GO:0022600 30 19 0,000 0,06019481 0,08406075 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,06019481 0,08400974 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,06019481 0,0839588 ! response to vitamin A GO:0033189 26 19 0,000 0,06019481 0,08390791 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,06019481 0,08385709 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,06019481 0,08380633 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,06019481 0,08375563 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,06019481 0,08370499 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,06019481 0,08365441 ! plasma membrane fusion GO:0045026 23 19 0,000 0,06019481 0,0836039 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,06019481 0,08355344 ! renal system process GO:0003014 35 19 0,000 0,06019481 0,08350305 ! vasodilation GO:0042311 33 19 0,000 0,06019481 0,08345272 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,06019481 0,08340244 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,06019481 0,08335223 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,06019481 0,08330208 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,06019481 0,08325199 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,06019481 0,08320196 ! sarcomere organization GO:0045214 23 19 0,000 0,06019481 0,08315199 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,06019481 0,08310207 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,06019481 0,08305222 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,06019481 0,08300243 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,06019481 0,0829527 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,06019481 0,08290303 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,06019481 0,08285341 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,06019481 0,08280386 ! protein stabilization GO:0050821 26 19 0,000 0,06019481 0,08275437 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,06326237 0,08691963 ! iron ion transport GO:0006826 37 20 0,000 0,06326237 0,08686773 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,06326237 0,0868159 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,06326237 0,08676414 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,06326237 0,08671243 ! response to vitamin GO:0033273 29 20 0,000 0,06326237 0,08666078 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,06326237 0,0866092 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,06326237 0,08655768 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,06326237 0,08650622 ! spinal cord development GO:0021510 31 20 0,000 0,06326237 0,08645482 ! response to ethanol GO:0045471 37 20 0,000 0,06326237 0,08640348 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,06326237 0,0863522 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,06326237 0,08630098 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,06326237 0,08624983 ! chromosome condensation GO:0030261 31 20 0,000 0,06326237 0,08619873 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,06326237 0,08614769 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,06326237 0,08609672 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,06326237 0,0860458 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,06326237 0,08599495 ! pallium development GO:0021543 38 20 0,000 0,06326237 0,08594416 ! DNA modification GO:0006304 28 20 0,000 0,06326237 0,08589342 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,06326237 0,08584275 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,06326237 0,08579213 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,06326237 0,08574158 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,06326237 0,08569108 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,06326237 0,08564064 ! collagen catabolic process GO:0030574 25 20 0,000 0,06326237 0,08559027 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,06326237 0,08553995 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,06326237 0,08548969 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,06326237 0,08543949 ! alditol metabolic process GO:0019400 24 20 0,000 0,06326237 0,08538935 ! actin filament-based movement GO:0030048 34 20 0,000 0,06326237 0,08533927 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,0663201 0,08941162 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,0663201 0,08935924 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,0663201 0,08930693 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,0663201 0,08925467 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,0663201 0,08920247 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,0663201 0,08915034 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,0663201 0,08909827 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,0663201 0,08904625 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,0663201 0,0889943 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,0663201 0,08894241 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,0663201 0,08889058 ! phototransduction GO:0007602 25 21 0,000 0,0663201 0,08883881 ! dendrite development GO:0016358 35 21 0,000 0,0663201 0,0887871 ! visual behavior GO:0007632 39 21 0,000 0,0663201 0,08873544 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,0663201 0,08868385 ! ovarian follicle development GO:0001541 30 21 0,000 0,0663201 0,08863232 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,0663201 0,08858085 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,0663201 0,08852944 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,0663201 0,08847809 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,0663201 0,0884268 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,0663201 0,08837557 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,0663201 0,08832439 ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,0663201 0,08827328 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,0663201 0,08822223 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,0663201 0,08817123 ! fatty acid transport GO:0015908 30 21 0,000 0,0663201 0,08812029 ! immunoglobulin production GO:0002377 33 21 0,000 0,0663201 0,08806942 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,0663201 0,0880186 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,0663201 0,08796784 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,0663201 0,08791714 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,0663201 0,08786649 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,0663201 0,08781591 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,0663201 0,08776538 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,0663201 0,08771491 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,0663201 0,0876645 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,0663201 0,08761415 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,0663201 0,08756385 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,0663201 0,08751361 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,0663201 0,08746343 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,0663201 0,08741331 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,0663201 0,08736325 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,06936802 0,09132596 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,06936802 0,09127371 ! viral genome replication GO:0019079 29 22 0,000 0,06936802 0,09122153 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,06936802 0,0911694 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,06936802 0,09111733 ! leukocyte adhesion GO:0007159 38 22 0,000 0,06936802 0,09106532 ! molting cycle process GO:0022404 40 22 0,000 0,06936802 0,09101338 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,06936802 0,09096149 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,06936802 0,09090966 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,06936802 0,09085789 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,06936802 0,09080617 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,06936802 0,09075452 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,06936802 0,09070293 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,06936802 0,09065139 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,06936802 0,09059991 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,06936802 0,0905485 ! regulation of behavior GO:0050795 38 22 0,000 0,06936802 0,09049713 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,06936802 0,09044583 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,06936802 0,09039459 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,06936802 0,0903434 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,06936802 0,09029227 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,06936802 0,0902412 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,06936802 0,09019019 ! blastocyst development GO:0001824 37 22 0,000 0,06936802 0,09013924 ! neural tube closure GO:0001843 33 22 0,000 0,06936802 0,09008834 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,06936802 0,0900375 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,07240617 0,09392791 ! neuron fate commitment GO:0048663 32 23 0,000 0,07240617 0,09387496 ! embryonic pattern specification GO:0009880 31 23 0,000 0,07240617 0,09382208 ! myelination GO:0042552 35 23 0,000 0,07240617 0,09376925 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,07240617 0,09371648 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,07240617 0,09366377 ! vesicle targeting GO:0006903 32 23 0,000 0,07240617 0,09361112 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,07240617 0,09355853 ! osteoblast differentiation GO:0001649 40 23 0,000 0,07240617 0,093506 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,07240617 0,09345353 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,07240617 0,09340111 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,07240617 0,09334876 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,07240617 0,09329646 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,07240617 0,09324422 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,07240617 0,09319204 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,07240617 0,09313992 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,07240617 0,09308786 ! cell fate determination GO:0001709 45 23 0,000 0,07240617 0,09303586 ! pentose metabolic process GO:0019321 31 23 0,000 0,07240617 0,09298391 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,07240617 0,09293202 ! spermatid development GO:0007286 33 23 0,000 0,07240617 0,09288019 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,07240617 0,09282842 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,07240617 0,0927767 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,07240617 0,09272505 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,07240617 0,09267345 ! telomere organization GO:0032200 32 23 0,000 0,07240617 0,0926219 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,07240617 0,09257042 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,07240617 0,09251899 ! regulation of amine transport GO:0051952 38 23 0,000 0,07240617 0,09246762 ! liver development GO:0001889 40 23 0,000 0,07240617 0,09241631 ! initiation of viral infection GO:0019059 42 24 0,000 0,07543457 0,09622823 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,07543457 0,09617489 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,07543457 0,09612161 ! superoxide metabolic process GO:0006801 32 24 0,000 0,07543457 0,09606839 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,07543457 0,09601522 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,07543457 0,09596212 ! sperm motility GO:0030317 27 24 0,000 0,07543457 0,09590907 ! vacuole organization GO:0007033 39 24 0,000 0,07543457 0,09585608 ! receptor metabolic process GO:0043112 37 24 0,000 0,07543457 0,09580315 ! neural crest cell development GO:0014032 39 24 0,000 0,07543457 0,09575028 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,07543457 0,09569747 ! primary neural tube formation GO:0014020 35 24 0,000 0,07543457 0,09564471 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,07543457 0,09559201 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,07543457 0,09553938 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,07543457 0,09548679 ! glutathione metabolic process GO:0006749 29 24 0,000 0,07543457 0,09543427 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,07543457 0,09538181 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,07543457 0,0953294 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,07845325 0,09908978 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,07845325 0,09903539 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,07845325 0,09898107 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,07845325 0,0989268 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,07845325 0,09887259 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,07845325 0,09881845 ! peptide transport GO:0015833 43 25 0,000 0,07845325 0,09876436 ! male gonad development GO:0008584 33 25 0,000 0,07845325 0,09871033 ! iron ion homeostasis GO:0055072 39 25 0,000 0,07845325 0,09865636 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,07845325 0,09860245 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,07845325 0,0985486 ! phospholipid transport GO:0015914 35 25 0,000 0,07845325 0,09849481 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,07845325 0,09844107 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,07845325 0,0983874 ! detection of light stimulus GO:0009583 30 25 0,000 0,07845325 0,09833378 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,07845325 0,09828022 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,07845325 0,09822672 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 0,000 0,07845325 0,09817328 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,08146226 0,10188319 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,08146226 0,10182782 ! translational initiation GO:0006413 43 26 0,000 0,08146226 0,10177251 ! circadian rhythm GO:0007623 42 26 0,000 0,08146226 0,10171726 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,08146226 0,10166207 ! post-embryonic development GO:0009791 42 26 0,000 0,08146226 0,10160694 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,08146226 0,10155187 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,08146226 0,10149685 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,08146226 0,1014419 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,08146226 0,10138701 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,08146226 0,10133217 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,08146226 0,1012774 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,08446161 0,10494959 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,08446161 0,10489292 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,08446161 0,10483632 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,08446161 0,10477977 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,08446161 0,10472329 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,08446161 0,10466686 ! acute-phase response GO:0006953 42 27 0,000 0,08446161 0,1046105 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,08446161 0,1045542 ! myofibril assembly GO:0030239 36 27 0,000 0,08446161 0,10449795 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,08446161 0,10444177 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,08446161 0,10438565 ! natural killer cell activation GO:0030101 35 27 0,000 0,08446161 0,10432959 ! lipid oxidation GO:0034440 38 27 0,000 0,08446161 0,10427359 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,08446161 0,10421765 ! negative regulation of leukocyte activation GO:0002695 39 27 0,000 0,08446161 0,10416177 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,08446161 0,10410595 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,08446161 0,10405019 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,08446161 0,10399448 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,08446161 0,10393884 ! gene silencing GO:0016458 41 27 0,000 0,08446161 0,10388326 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,08745133 0,10750298 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,08745133 0,10744555 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,08745133 0,10738818 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,08745133 0,10733088 ! cell junction assembly GO:0034329 56 28 0,000 0,08745133 0,10727364 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,08745133 0,10721645 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,08745133 0,10715933 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,08745133 0,10710227 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,08745133 0,10704527 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,08745133 0,10698833 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,08745133 0,10693146 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,08745133 0,10687464 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,08745133 0,10681788 ! mesoderm formation GO:0001707 46 28 0,000 0,08745133 0,10676118 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,08745133 0,10670455 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,08745133 0,10664797 ! ensheathment of neurons GO:0007272 43 28 0,000 0,08745133 0,10659145 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 0,000 0,08745133 0,10653499 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,08745133 0,1064786 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,08745133 0,10642226 ! neural tube formation GO:0001841 41 28 0,000 0,08745133 0,10636598 ! placenta development GO:0001890 37 28 0,000 0,08745133 0,10630976 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,09043147 0,10987447 ! regulation of innate immune response GO:0045088 38 29 0,000 0,09043147 0,10981646 ! ovulation cycle process GO:0022602 41 29 0,000 0,09043147 0,10975851 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,09043147 0,10970062 ! protein targeting to membrane GO:0006612 53 29 0,000 0,09043147 0,10964279 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,09043147 0,10958503 ! mismatch repair GO:0006298 34 29 0,000 0,09043147 0,10952732 ! muscle cell development GO:0055001 38 29 0,000 0,09043147 0,10946967 ! formation of primary germ layer GO:0001704 48 29 0,000 0,09043147 0,10941209 ! telencephalon development GO:0021537 52 29 0,000 0,09043147 0,10935456 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,09043147 0,1092971 ! eye morphogenesis GO:0048592 51 29 0,000 0,09043147 0,10923969 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,09043147 0,10918235 ! tissue homeostasis GO:0001894 42 29 0,000 0,09043147 0,10912507 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,09340204 0,1126506 ! collagen metabolic process GO:0032963 40 30 0,000 0,09340204 0,11259156 ! organic anion transport GO:0015711 51 30 0,000 0,09340204 0,11253258 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,09340204 0,11247366 ! spliceosome assembly GO:0000245 49 30 0,000 0,09340204 0,11241481 ! spindle organization GO:0007051 37 30 0,000 0,09340204 0,11235601 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,09340204 0,11229728 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,09340204 0,11223861 ! ceramide metabolic process GO:0006672 43 30 0,000 0,09340204 0,11218 ! ovulation cycle GO:0042698 43 30 0,000 0,09340204 0,11212145 ! hindbrain development GO:0030902 45 30 0,000 0,09340204 0,11206296 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,09340204 0,11200453 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,09340204 0,11194617 ! negative regulation of cell activation GO:0050866 44 30 0,000 0,09340204 0,11188786 ! response to heat GO:0009408 41 30 0,000 0,09340204 0,11182962 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,09340204 0,11177143 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,09340204 0,11171331 ! negative regulation of secretion GO:0051048 49 31 0,000 0,09636308 0,11519495 ! glial cell differentiation GO:0010001 55 31 0,000 0,09636308 0,11513511 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,09636308 0,11507533 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,09636308 0,11501561 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,09636308 0,11495596 ! odontogenesis GO:0042476 50 31 0,000 0,09636308 0,11489637 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,09636308 0,11483683 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,09636308 0,11477736 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,09636308 0,11471796 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,09636308 0,11465861 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,09636308 0,11459932 ! cell fate specification GO:0001708 37 31 0,000 0,09636308 0,1145401 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,09636308 0,11448093 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,09636308 0,11442183 ! RNA modification GO:0009451 40 31 0,000 0,09636308 0,11436279 ! regulation of muscle development GO:0048634 48 32 0,000 0,09931462 0,11780486 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,09931462 0,11774414 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,09931462 0,11768348 ! meiosis I GO:0007127 52 32 0,000 0,09931462 0,11762288 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,09931462 0,11756234 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,09931462 0,11750187 ! peripheral nervous system development GO:0007422 53 32 0,000 0,09931462 0,11744145 ! regulation of protein stability GO:0031647 48 32 0,000 0,09931462 0,1173811 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,09931462 0,11732082 ! cytokine production GO:0001816 44 32 0,000 0,09931462 0,11726059 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,09931462 0,11720043 ! vesicle localization GO:0051648 47 32 0,000 0,09931462 0,11714032 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,10225669 0,12054863 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,10225669 0,12048688 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,10225669 0,12042518 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,10225669 0,12036355 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,10225669 0,12030199 ! sister chromatid segregation GO:0000819 46 33 0,000 0,10225669 0,12024048 ! ear morphogenesis GO:0042471 42 33 0,000 0,10225669 0,12017904 ! actomyosin structure organization GO:0031032 43 33 0,000 0,10225669 0,12011766 ! cell junction organization GO:0034330 63 33 0,000 0,10225669 0,12005635 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,10225669 0,11999509 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,10225669 0,1199339 ! nucleus organization GO:0006997 49 33 0,000 0,10225669 0,11987277 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,10225669 0,11981171 ! female gonad development GO:0008585 49 33 0,000 0,10225669 0,1197507 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,10225669 0,11968976 ! positive regulation of cell development GO:0010720 54 33 0,000 0,10225669 0,11962888 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,10225669 0,11956806 ! regulation of proteolysis GO:0030162 50 33 0,000 0,10225669 0,11950731 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,10225669 0,11944661 ! cytokinesis GO:0000910 52 33 0,000 0,10225669 0,11938598 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,10225669 0,11932541 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,10518931 0,1226853 ! mRNA catabolic process GO:0006402 48 34 0,000 0,10518931 0,12262312 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,10518931 0,122561 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,10518931 0,12249895 ! feeding behavior GO:0007631 45 34 0,000 0,10518931 0,12243695 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,10518931 0,12237502 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,10518931 0,12231315 ! neuron migration GO:0001764 46 34 0,000 0,10518931 0,12225135 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,10518931 0,12218961 ! female gamete generation GO:0007292 43 34 0,000 0,10518931 0,12212793 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,10518931 0,12206631 ! polyol metabolic process GO:0019751 44 34 0,000 0,10518931 0,12200475 ! aerobic respiration GO:0009060 47 34 0,000 0,10518931 0,12194326 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,10518931 0,12188182 ! embryonic organ development GO:0048568 45 34 0,000 0,10518931 0,12182045 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,10518931 0,12175914 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,10811253 0,12507988 ! Notch signaling pathway GO:0007219 56 35 0,000 0,10811253 0,125017 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,10811253 0,12495418 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,10811253 0,12489142 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,10811253 0,12482872 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,10811253 0,12476609 ! regulation of action potential in neuron GO:0019228 54 35 0,000 0,10811253 0,12470351 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,10811253 0,12464101 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,10811253 0,12457856 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,10811253 0,12451618 ! glycogen metabolic process GO:0005977 48 35 0,000 0,10811253 0,12445386 ! pigment metabolic process GO:0042440 61 35 0,000 0,10811253 0,1243916 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,11102636 0,12768031 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,11102636 0,1276165 ! negative regulation of binding GO:0051100 58 36 0,000 0,11102636 0,12755276 ! neural tube development GO:0021915 50 36 0,000 0,11102636 0,12748907 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,11102636 0,12742546 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,11102636 0,1273619 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,11102636 0,12729841 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,11102636 0,12723499 ! glucan metabolic process GO:0044042 49 36 0,000 0,11102636 0,12717162 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,11393083 0,13043351 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,11393083 0,13036861 ! learning GO:0007612 67 37 0,000 0,11393083 0,13030379 ! ion transmembrane transport GO:0034220 56 37 0,000 0,11393083 0,13023902 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,11393083 0,13017432 ! regulation of protein secretion GO:0050708 51 37 0,000 0,11393083 0,13010969 ! amino acid activation GO:0043038 52 37 0,000 0,11393083 0,13004512 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,11393083 0,12998061 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,11682598 0,13321753 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,11682598 0,13315152 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,11682598 0,13308557 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,11682598 0,13301969 ! regulation of T cell proliferation GO:0042129 58 38 0,000 0,11682598 0,13295387 ! phagocytosis GO:0006909 60 38 0,000 0,11682598 0,13288811 ! pigmentation GO:0043473 74 38 0,000 0,11682598 0,13282242 ! maintenance of location in cell GO:0051651 69 38 0,000 0,11682598 0,1327568 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,11971184 0,13596901 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,11971184 0,1359019 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,11971184 0,13583485 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,11971184 0,13576787 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,11971184 0,13570096 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,11971184 0,13563411 ! male sex differentiation GO:0046661 53 39 0,000 0,11971184 0,13556733 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,11971184 0,13550061 ! chromatin remodeling GO:0006338 68 39 0,000 0,11971184 0,13543396 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,11971184 0,13536737 ! developmental growth GO:0048589 62 39 0,000 0,11971184 0,13530085 ! cell growth GO:0016049 61 39 0,000 0,11971184 0,1352344 ! synapse organization GO:0050808 55 39 0,000 0,11971184 0,13516801 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,12258844 0,13834809 ! response to calcium ion GO:0051592 58 40 0,000 0,12258844 0,13828024 ! regulation of tube size GO:0035150 60 40 0,000 0,12258844 0,13821245 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,12258844 0,13814474 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,12258844 0,13807708 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,12258844 0,1380095 ! peptide metabolic process GO:0006518 56 40 0,000 0,12258844 0,13794198 ! inner ear development GO:0048839 57 40 0,000 0,12258844 0,13787453 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,12258844 0,13780714 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,12258844 0,13773982 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,12258844 0,13767256 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,12545579 0,14082398 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,12545579 0,14075528 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,12545579 0,14068665 ! glucose transport GO:0015758 52 41 0,000 0,12545579 0,14061809 ! endosome transport GO:0016197 71 41 0,000 0,12545579 0,1405496 ! striated muscle contraction GO:0006941 62 41 0,000 0,12545579 0,14048117 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,12545579 0,14041281 ! regulation of T cell differentiation GO:0045580 59 41 0,000 0,12545579 0,14034452 ! biopolymer methylation GO:0043414 62 41 0,000 0,12545579 0,14027629 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,12545579 0,14020813 ! cellular component disassembly GO:0022411 64 42 0,000 0,12831395 0,14333272 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,12831395 0,14326314 ! hexose transport GO:0008645 54 42 0,000 0,12831395 0,14319363 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,12831395 0,14312419 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,12831395 0,14305481 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,12831395 0,1429855 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,12831395 0,14291626 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,12831395 0,14284708 ! regulation of cell shape GO:0008360 78 42 0,000 0,12831395 0,14277798 ! leukocyte migration GO:0050900 60 43 0,000 0,13116292 0,14587752 ! tRNA processing GO:0008033 49 43 0,000 0,13116292 0,14580702 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,13116292 0,14573658 ! methylation GO:0032259 64 43 0,000 0,13116292 0,14566621 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,13400275 0,14874822 ! glycolysis GO:0006096 53 44 0,000 0,13400275 0,14867647 ! regulation of action potential GO:0001508 71 44 0,000 0,13400275 0,14860478 ! regulation of ion transport GO:0043269 57 44 0,000 0,13400275 0,14853316 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,13400275 0,14846162 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,13400275 0,14839014 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,13400275 0,14831873 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,13400275 0,14824739 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,13400275 0,14817611 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,13400275 0,14810491 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,13400275 0,14803377 ! RNA catabolic process GO:0006401 64 45 0,000 0,13683345 0,1510883 ! positive regulation of defense response GO:0031349 59 45 0,000 0,13683345 0,15101581 ! regulation of translational initiation GO:0006446 64 45 0,000 0,13683345 0,15094338 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,13683345 0,15087102 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,13683345 0,15079872 ! cell recognition GO:0008037 58 45 0,000 0,13683345 0,1507265 ! cell maturation GO:0048469 60 45 0,000 0,13683345 0,15065435 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,13965507 0,15368739 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,13965507 0,15361389 ! cell redox homeostasis GO:0045454 63 46 0,000 0,13965507 0,15354046 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,13965507 0,15346711 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,13965507 0,15339382 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,14246762 0,15640836 ! viral infectious cycle GO:0019058 71 47 0,000 0,14246762 0,15633374 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,14246762 0,15625919 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,14246762 0,15618471 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,14246762 0,1561103 ! negative regulation of immune system process GO:0002683 73 47 0,000 0,14246762 0,15603596 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,14246762 0,1559617 ! chloride transport GO:0006821 67 48 0,000 0,14527114 0,1589551 ! response to temperature stimulus GO:0009266 62 48 0,000 0,14527114 0,15887951 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,14527114 0,158804 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,14527114 0,15872856 ! gastrulation GO:0007369 73 48 0,000 0,14527114 0,15865319 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,14527114 0,15857789 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,14527114 0,15850266 ! regulation of endocytosis GO:0030100 63 48 0,000 0,14527114 0,15842751 ! nuclear export GO:0051168 69 48 0,000 0,14527114 0,15835242 ! regulation of lymphocyte differentiation GO:0045619 69 48 0,000 0,14527114 0,15827741 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,14527114 0,15820247 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,14806565 0,16116942 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,14806565 0,16109319 ! sensory perception of smell GO:0007608 61 49 0,000 0,14806565 0,16101702 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,14806565 0,16094092 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,14806565 0,1608649 ! RNA elongation GO:0006354 62 49 0,000 0,14806565 0,16078895 ! germ cell development GO:0007281 68 49 0,000 0,14806565 0,16071307 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,14806565 0,16063726 ! cartilage development GO:0051216 70 49 0,000 0,14806565 0,16056153 ! maintenance of location GO:0051235 84 49 0,000 0,14806565 0,16048586 ! regulation of actin filament length GO:0030832 72 50 0,000 0,15085119 0,16342804 ! ear development GO:0043583 72 50 0,000 0,15085119 0,1633511 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,15085119 0,16327423 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,15085119 0,16319743 ! proton transport GO:0015992 75 50 0,000 0,15085119 0,1631207 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,15085119 0,16304405 ! hydrogen transport GO:0006818 77 51 0,000 0,15362777 0,16596706 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,15362777 0,16588915 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,15362777 0,1658113 ! transition metal ion transport GO:0000041 74 52 0,000 0,15639544 0,16871929 ! regulation of cellular component size GO:0032535 74 52 0,000 0,15639544 0,16864019 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,15639544 0,16856116 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,15915422 0,17145419 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,15915422 0,17137392 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,15915422 0,17129373 ! single fertilization GO:0007338 59 53 0,000 0,15915422 0,17121361 ! amino acid transport GO:0006865 84 54 0,000 0,16190413 0,17409046 ! regulation of mitosis GO:0007088 84 54 0,000 0,16190413 0,17400911 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,16190413 0,17392784 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,16190413 0,17384664 ! DNA catabolic process GO:0006308 67 54 0,000 0,16190413 0,17376551 ! detection of external stimulus GO:0009581 66 54 0,000 0,16190413 0,17368447 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,16190413 0,1736035 ! exocytosis GO:0006887 74 55 0,000 0,16464521 0,17646038 ! mesoderm development GO:0007498 76 55 0,000 0,16464521 0,17637819 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,16464521 0,17629608 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,16464521 0,17621404 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,16737747 0,17905497 ! carbohydrate transport GO:0008643 74 57 0,000 0,17010096 0,18188387 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,17010096 0,18179935 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,17010096 0,18171491 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,17010096 0,18163055 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,17010096 0,18154627 ! camera-type eye development GO:0043010 88 57 0,000 0,17010096 0,18146206 ! secondary metabolic process GO:0019748 84 57 0,000 0,17010096 0,18137794 ! developmental maturation GO:0021700 75 57 0,000 0,17010096 0,18129389 ! gonad development GO:0008406 79 57 0,000 0,17010096 0,18120992 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,17281569 0,18401671 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,1755217 0,18681162 ! actin filament organization GO:0007015 95 59 0,000 0,1755217 0,18672522 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,1755217 0,18663889 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,17821901 0,18941947 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,17821901 0,18933198 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,17821901 0,18924457 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,17821901 0,18915724 ! regulation of heart contraction GO:0008016 91 60 0,000 0,17821901 0,18906999 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,17821901 0,18898282 ! fertilization GO:0009566 68 60 0,000 0,17821901 0,18889573 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,18090766 0,19165712 ! meiosis GO:0007126 96 61 0,000 0,18090766 0,19156888 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,18090766 0,19148072 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,18090766 0,19139264 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,18090766 0,19130465 ! extracellular matrix organization GO:0030198 103 61 0,000 0,18090766 0,19121673 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,18090766 0,1911289 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,18090766 0,19104114 ! amine catabolic process GO:0009310 90 62 0,000 0,18358766 0,19378229 ! neurotransmitter transport GO:0006836 81 62 0,000 0,18358766 0,1936934 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,18358766 0,19360459 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,18358766 0,19351586 ! meiotic cell cycle GO:0051321 97 62 0,000 0,18358766 0,19342721 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,18625904 0,19615192 ! appendage morphogenesis GO:0035107 93 64 0,000 0,18892183 0,19886509 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,18892183 0,19877412 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,18892183 0,19868323 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,18892183 0,19859242 ! hexose catabolic process GO:0019320 82 64 0,000 0,18892183 0,1985017 ! reproductive structure development GO:0048608 90 65 0,000 0,19157607 0,20119861 ! appendage development GO:0048736 94 65 0,000 0,19157607 0,20110678 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,19157607 0,20101504 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,19157607 0,20092337 ! defense response to bacterium GO:0042742 73 65 0,000 0,19157607 0,2008318 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,19157607 0,2007403 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,19422177 0,20341989 ! antigen processing and presentation GO:0019882 96 66 0,000 0,19422177 0,2033273 ! axon guidance GO:0007411 99 66 0,000 0,19422177 0,20323479 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,19422177 0,20314237 ! regulation of immune effector process GO:0002697 101 66 0,000 0,19422177 0,20305003 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,19685896 0,20571359 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,19685896 0,20562017 ! learning or memory GO:0007611 123 68 0,000 0,19948768 0,20827129 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,19948768 0,20817679 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,19948768 0,20808238 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,19948768 0,20798806 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,19948768 0,20789382 ! rhythmic process GO:0048511 105 68 0,000 0,19948768 0,20779966 ! inorganic anion transport GO:0015698 93 68 0,000 0,19948768 0,20770559 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,20210794 0,21033858 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,20210794 0,21024344 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,20210794 0,2101484 ! response to metal ion GO:0010038 103 70 0,000 0,20471977 0,21276795 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,20471977 0,21267185 ! eye development GO:0001654 111 70 0,000 0,20471977 0,21257583 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,20471977 0,2124799 ! phosphoinositide-mediated signaling GO:0048015 109 71 0,000 0,2073232 0,21508496 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,2073232 0,21498799 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,2073232 0,21489111 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,2073232 0,21479431 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,20991826 0,21738496 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,20991826 0,21728713 ! negative regulation of transport GO:0051051 116 73 0,000 0,21250497 0,21986569 ! regulation of blood pressure GO:0008217 107 73 0,000 0,21250497 0,21976683 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,21250497 0,21966806 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,21250497 0,21956938 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,21508336 0,22213369 ! digestion GO:0007586 97 74 0,000 0,21508336 0,22203399 ! response to inorganic substance GO:0010035 115 75 0,000 0,21765346 0,22458634 ! response to nutrient GO:0007584 104 75 0,000 0,21765346 0,22448563 ! regulation of ligase activity GO:0051340 114 75 0,000 0,21765346 0,22438501 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,21765346 0,22428448 ! amine biosynthetic process GO:0009309 97 76 0,000 0,22021529 0,22682274 ! tRNA metabolic process GO:0006399 95 76 0,000 0,22021529 0,2267212 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,22021529 0,22661976 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,22276888 0,22914509 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,22276888 0,22904265 ! sex differentiation GO:0007548 105 77 0,000 0,22276888 0,22894031 ! protein ubiquitination GO:0016567 125 77 0,000 0,22276888 0,22883806 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,22276888 0,2287359 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,22276888 0,22863383 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,22276888 0,22853185 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,22531425 0,23104002 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,22531425 0,23093706 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,22531425 0,2308342 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,22785143 0,2333296 ! cellular respiration GO:0045333 107 79 0,000 0,22785143 0,23322576 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,22785143 0,23312201 ! regulation of lyase activity GO:0051339 133 79 0,000 0,22785143 0,23301836 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,22785143 0,23291479 ! chromatin assembly GO:0031497 102 80 0,000 0,23038044 0,23539539 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,23038044 0,23529086 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,23038044 0,23518643 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,23038044 0,23508209 ! forebrain development GO:0030900 131 80 0,000 0,23038044 0,23497784 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,23290132 0,23744372 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,23290132 0,23733852 ! vitamin metabolic process GO:0006766 103 81 0,000 0,23290132 0,23723341 ! detection of stimulus GO:0051606 108 82 0,000 0,23541409 0,23968676 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,23791876 0,24212972 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of defense response GO:0031347 117 84 0,000 0,24041538 0,24456231 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,24041538 0,24445419 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,24041538 0,24434617 ! sterol metabolic process GO:0016125 120 84 0,000 0,24041538 0,24423824 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,24290396 0,24665744 ! rRNA metabolic process GO:0016072 107 85 0,000 0,24290396 0,24654859 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,24290396 0,24643984 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,24538453 0,24884675 ! nucleosome organization GO:0034728 114 87 0,000 0,24785712 0,25124344 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,24785712 0,25113276 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,24785712 0,25102218 ! female pregnancy GO:0007565 130 87 0,000 0,24785712 0,25091169 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,25032174 0,25329521 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,25032174 0,25318382 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,25032174 0,25307253 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,25277843 0,25544393 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,25277843 0,25533175 ! regulation of T cell activation GO:0050863 128 89 0,000 0,25277843 0,25521966 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,25522721 0,25757902 ! hormone metabolic process GO:0042445 121 90 0,000 0,25522721 0,25746605 ! ATP metabolic process GO:0046034 137 91 0,000 0,25766811 0,2598144 ! response to virus GO:0009615 122 91 0,000 0,25766811 0,25970054 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,26010114 0,26203794 ! DNA recombination GO:0006310 146 92 0,000 0,26010114 0,26192322 ! sulfur metabolic process GO:0006790 118 92 0,000 0,26010114 0,26180859 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,26252634 0,26413411 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,26252634 0,26401862 ! electron transport chain GO:0022900 123 94 0,000 0,26494373 0,2663333 ! response to oxidative stress GO:0006979 141 94 0,000 0,26494373 0,26621694 ! angiogenesis GO:0001525 149 95 0,000 0,26735334 0,26852082 ! carboxylic acid transport GO:0046942 147 95 0,000 0,26735334 0,26840361 GO:0015849|organic acid transport, ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,26975518 0,27069673 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,27214929 0,2729801 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,27214929 0,2728611 ! extracellular structure organization GO:0043062 156 99 0,000 0,27691439 0,27751769 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,27691439 0,27739682 ! regulation of translation GO:0006417 151 100 0,000 0,27928544 0,2796502 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,27928544 0,27952851 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,27928544 0,27940692 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,27928544 0,27928544